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Invasion of an organism's body tissues by disease-causing agents

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  • Nov 23, 2021LATEST
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Best podcasts about infectious

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Latest podcast episodes about infectious

Order of Man: Protect | Provide | Preside
GAD SAAD | How Infectious Ideas Kill Common Sense

Order of Man: Protect | Provide | Preside

Play Episode Listen Later Nov 23, 2021 73:48


We all know how dangerous ideology can be and, yet, some of the most destructive ideas tend to be the most pervasive in society. Why is that? And, how do these parasitic ideas spread so effectively?   My guest today is evolutionary psychologist and author of The Parasitic Mind: How infectious Ideas are Killing Common Sense, Gad Saad. Today, Gad and I discuss his guiding principles: truth and freedom, what he refers to as the “Holy Trinity of Bullshit,” the dangers of post-modernism, the other deadly sin most people don't talk about, the woke mob's desire to eliminate culture and history, and how to use your voice against these dangerous ideologies.   SHOW HIGHLIGHTS:   The importance of telling the hard truth Postmodernism is a form of intellectual terrorism The idea pathogen of social constructivism Life is about tradeoffs The distinction between feeling and thinking Using the lexicographic rule in politics Sifting through all of the information we have available Don't set out to offend, but be willing to offend The more things change, the more they stay the same Choosing what is worth pursuing The attacks on truth are relentless Most people lack the courage to use their voice Walk through life like a honey badger   Want maximum health, wealth, relationships, and abundance in your life? Sign up for our free course, 30 Days to Battle Ready ⠀ Download the NEW Order of Man Twelve-Week Battle Planner App and maximize your week.

Behind the Microscope
Michael Mina, MD-PhD - Leaders are Communicators

Behind the Microscope

Play Episode Listen Later Nov 22, 2021 73:09


Dr. Michael Mina is the newly appointed Chief Science Officer at eMed and a former Assistant Professor of Epidemiology as well as Immunology and Infectious disease at Harvard TH Chan School of Public Health. Dr. Mina earned his MD and PhD from Emory University, with postdoctoral fellowships at Princeton University and Harvard Medical school. He completed his residency training in clinical pathology at Brigham and Women's Hospital before joining the faculty of Harvard. Today, Dr. Mina shares his incredible journey from undergrad to Buddhist monk to MD-PhD student to Assistant professor, with stops in Sri Lanka, Nicaragua, and South Africa. Credits: Our deepest thanks to Dr. Mina for joining us today! Dr. Mina's Faculty Page: https://www.emed.com/michael-mina?hsLang=en Follow Dr. Mina on Twitter: @michaelmina_lab Host: Bejan Saeedi Co-Host and Audio Engineer – Joe Behnke Executive Producer and Social Media Coordinator – Carey Jansen Executive Producer – Michael Sayegh Faculty Advisor – Dr. Brian Robinson Twitter: @behindthescope_ Instagram: @behindthemicroscopepod Facebook: @behindthemicroscope1 Website: behindthemicroscope.com

Android Central Podcast
Infectious Audio

Android Central Podcast

Play Episode Listen Later Nov 22, 2021 89:11


Nick and Jerry spend the episode chatting with fellow Android Central-ites Chris Wedel and Andrew Myrick. Chris shares his unpleasant experience with the Samsung Galaxy Buds Pro, plus the gang discuss Motorola's rise to number three smartphone vendor in the U.S. And that's just the tip of the iceberg of everything they cover — check it out! Links: Chris Wedel (@chris_wedel) / Twitter Andrew Myrick (@andymyrick) / Twitter Samsung Galaxy Buds Pro are infectious in all the wrong ways | Android Central How Motorola became number 3 against all odds | Android Central Samsung publishes official One UI 4 (Android 12) update schedule in the US | Android Central Foldables may be the future but Samsung is betting big on regular phones in 2022 | Android Central Qualcomm hints at a strong Snapdragon presence in the Galaxy S22 series | Android Central The Pixel 6 Pro falls short on 5G speeds when compared to the Galaxy S21 | Android Central The Pixel 6 mid-November patch could finally fix the fingerprint scanner | Android Central Google confirms the Pixel 6 and 6 Pro don't actually charge at 30W | Android Central New Google Camera update brings some Pixel 6 features to its predecessors | Android Central Samsung is bringing some of Galaxy Watch 4's best features to older Galaxy watches | Android Central Apple does the bare minimum to get in front of right to repair laws and the internet loves it | Android Central History repeats itself as Meta accused of stealing tech for new VR gloves | Android Central You can now pick up a pair of Nreal Light AR glasses at Verizon stores | Android Central Sponsors: Shopify: Supercharge your knowledge, your sales and your success. Grow your business with Shopify today - go to Shopify.com/acp. Indeed: Choose Indeed and join 3 million companies worldwide who use Indeed to hire great people and help grow their teams faster. Get started right now with a free $75 sponsored job credit at indeed.com/acp. Offer valid through December 31. Terms and conditions apply.

Beer'd Al Podcast
Very Special Episode: Squeeze Box ft. Russ from Infectious Groove

Beer'd Al Podcast

Play Episode Listen Later Nov 19, 2021 66:35


This is important! This means something! Lauren is joined (again) by Russ from the Infectious Groove Podcast to discuss something HUGE. We're talking about the "Weird Al" vinyl box set Squeeze Box. How can we talk about such a comprehensive box set in an hour? Is it possible? Listen and find out! We're excited to have a fellow OddPod on the show this week! Huzzah! Watch Russ talk about this box set on YouTube! https://www.youtube.com/watch?v=JarQQaC24cw&t=3s Check out Infectious Groove! https://www.infectiousgroovepodcast.com/   Beer'd Al is an affiliate of the OddPods Media Network. OddPods promo for 500 Section Lounge.

KinkyCast
#408 - Dr. Dan - Takes on COVID!

KinkyCast

Play Episode Listen Later Nov 19, 2021 91:43


This week we have Dr. Dan, an actual infectious disease doctor, to lay out the details on COVID in the poly/kink communities. You will hear advice to minimize the risk of acquiring and spreading COVID. Topics include, how to convince the vaccine hesitant people in your life to get vaccinated, how to best test in case of an exposure, what to do if someone gets COVID, and a whole lot more! https://www.kinkycast.com/archive/2021-archive/408---dr-dan---takes-on.html

New Books in Medicine
John S. Tregoning, "Infectious: Pathogens and How We Fight Them" (Oneworld, 2021)

New Books in Medicine

Play Episode Listen Later Nov 16, 2021 47:35


Nature wants you dead. Not just you, but your children and everyone you have ever met and everyone they have ever met; in fact, everyone. It wants you to cough and sneeze and poop yourself into an early grave. It wants your blood vessels to burst and pustules to explode all over your body. And - until recently - it was really good at doing this... Covid-19 may be only the first of many modern pandemics. The subject of infection and how to fight it grows more urgent every day. How do pathogens cause disease? And what tools can we give our bodies to do battle? Dr John S. Tregoning has dedicated his career to answering these questions. Infectious: Pathogens and How We Fight Them (Oneworld, 2021) uncovers fascinating success stories in immunology and virology, making this book not only a vital overview of infection, but also a hopeful story of ongoing human ingenuity. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/medicine

New Books Network
John S. Tregoning, "Infectious: Pathogens and How We Fight Them" (Oneworld, 2021)

New Books Network

Play Episode Listen Later Nov 16, 2021 47:35


Nature wants you dead. Not just you, but your children and everyone you have ever met and everyone they have ever met; in fact, everyone. It wants you to cough and sneeze and poop yourself into an early grave. It wants your blood vessels to burst and pustules to explode all over your body. And - until recently - it was really good at doing this... Covid-19 may be only the first of many modern pandemics. The subject of infection and how to fight it grows more urgent every day. How do pathogens cause disease? And what tools can we give our bodies to do battle? Dr John S. Tregoning has dedicated his career to answering these questions. Infectious: Pathogens and How We Fight Them (Oneworld, 2021) uncovers fascinating success stories in immunology and virology, making this book not only a vital overview of infection, but also a hopeful story of ongoing human ingenuity. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

Conversations With Coleman
Parasites of the Mind with Andy Norman [S2 Ep.34]

Conversations With Coleman

Play Episode Listen Later Nov 12, 2021 76:52


My guest today is Andy Norman. Andy is a philosopher and the director of the humanism initiative at Carnegie Mellon University. He is also the founder of CIRCE, the Cognitive Immunology Research Collaborative. In this episode, we discuss his new book "Mental immunity: Infectious ideas, Mind parasites, and the Search for a Better Way to Think." We talk about how bad ideas operate like parasites. We talk about the notion of a mental immune system. We talk about the virtues and dangers of being open-minded. We discussed Richard Dawkins's notion of selfish genes and his coinage of the word "Meme". We talked about conspiracy theories, we talked about whether you should seek out disagreements with your friends and family or whether you should simply keep the peace. We talk about policies like stop and frisk and how to weigh lives saved against more abstract moral gains. We talk about what makes good ideas, "good" and bad ideas, "bad". We talk about the Milgram experiment and the Stanford prison experiment. We talk about cultures of cheating and cultures of honesty in different sports, and much more.

Radio Boston
When will everyone need a booster shot?

Radio Boston

Play Episode Listen Later Nov 9, 2021 14:35


We turn to Dr. Shira Doron, Infectious disease physician and hospital epidemiologist at Tufts Medical Center.

KinkyCast
#406 - 1 MD and a Microphone - Dr. Dan - Frolicon 2021

KinkyCast

Play Episode Listen Later Nov 5, 2021 72:13


Dr. Dan is back! Hey, did you know how funny the good doc is? You need to listen, laugh, and learn a few things that will make your life a bit longer. Dr. Dan mixes great information with humor to keep your attention and cover info the is not readily available to non-medical people, like most of us. This is not the “Covid show,” it will post in a few weeks. This show covers infectious issues from STI/STDs to fruit bats. https://www.kinkycast.com/archive/2021-archive/406---1-md-and-a-microphone.html

Love N’ Kink
Infectious Insecurities

Love N’ Kink

Play Episode Listen Later Nov 5, 2021 44:39


Was your Halloween as wild as ours?? Yours was probably wilder if I'm being honest. This was a tough week for us for various reasons but as always we are open books & letting you in on how we handle JEALOUSY. Plus, we answer most of the questions you submitted to us via Instagram! The play buttons just right there so what are you waiting for? Press Play!For more places to see or hear from us or anyone we've talked about click the links below!Marleys Links:https://onlyfans.com/marleyroze Only Fanshttps://www.tiktok.com/@itsmarleyroze Tiktokhttps://www.instagram.com/marley_roze/ IGGideons Links:https://onlyfans.com/gideonmazikeen Only Fanshttps://www.tiktok.com/@infamousgideon Tiktokhttps://www.instagram.com/gideonmazikeen/ IGMia/Elena Links:https://onlyfans.com/lustyfoxxy Only Fanshttps://www.instagram.com/lustyfoxxy/ IGSkylove's Links:https://onlyfans.com/sd.suga Only Fanshttps://www.instagram.com/skylove.kr/ IGPodcast Links:https://lovenkink.com/ Websitehttps://www.tiktok.com/@marleyandgideon Tiktokhttps://www.instagram.com/_lovenkink/ Instagram

Show Me the Science
Vaccines approved for younger kids

Show Me the Science

Play Episode Listen Later Nov 3, 2021 17:01


COVID-19 has killed more than 5 million people around the world, with more than 740,000 dead in the United States. Although the virus is far more deadly in older people than in children, more than 650 kids have died of COVID-19 in the United States. Meanwhile, during the surge caused by the delta variant, hospitalizations of children increased fivefold. Some 90% of the 12- to 17-year-olds hospitalized for the illness? were unvaccinated, and none of the hospitalized children under age 12 were vaccinated because they were not eligible. Until now. The Food and Drug Administration and the Centers for Disease Control & Prevention have authorized emergency use of the Pfizer-BioNTech COVID-19 vaccine for children ages 5 to  11. Infectious diseases specialist Jason Newland, MD, a professor of pediatrics, called the authorization a “ginormous” development in the fight against COVID-19. Newland has been involved in the vaccine trials in younger patients, and he says that as more young children are able to be vaccinated, fewer and fewer will require hospitalization. And he says better protection for kids also will provide better protection for the adults with whom they live. The podcast, “Show Me the Science,” is produced by the Office of Medical Public Affairs at Washington University School of Medicine in St. Louis.

500 Section Lounge
E104: EMERGENCY GUEST-Russ From Infectious Groove

500 Section Lounge

Play Episode Listen Later Nov 2, 2021 70:55


The guys had a time cross-up with their guest this week so they had to call an audible and get an emergency guest, and WOW, did they have a good one! Russ from the Infectious Groove Podcast joined the guys in the Lounge! Russ is the main co-host of the show, and you can see why the show is successful! He's funny, kind, thoughtful, and can be brilliant on the fly!Sam starts, right away, with the hard-hitting, "Do you know the technical name of a Rolodex?" The topic of Joe Elliot & Billy Joel singing "Pour Some Sugar On Me," comes up and that spurs conversation about the lyrical "genius" of that song! ALSO, Russ mentions "probably the nastiest lyric from all songs that go unnoticed/ignored." Do you know which line he's talking about?! While they talk about music a bunch, they also talk about another high-profile topic... When is the appropriate time to start playing Christmas music?! Sam has a VERY steadfast time when he deems it acceptable and is finding it harder and harder to stay quiet about it! Russ, too, has a stance on it! With that, they talk about Russ' past profession, and how that correlates to his feeling!The show is fantastic! Russ will return on a date that he's actually scheduled to be a guest! He is great! SO, sit back, relax, & #grabalisten!Find out everything Infectious Groove at https://www.infectiousgroovepodcast.com/

ASCO Guidelines Podcast Series
CAR-T Cell Therapy: Management of irAEs Guideline (Part 2)

ASCO Guidelines Podcast Series

Play Episode Listen Later Nov 1, 2021 30:13


An interview with Dr. Bianca Santomasso from Memorial Sloan Kettering Cancer Center and Dr. Monalisa Ghosh from the University of Michigan Health System, authors on “Management of Immune-Related Adverse Events in Patients Treated With Chimeric Antigen Receptor T-Cell Therapy: ASCO Guideline.” They discuss recommendations for management of irAEs in patients treated with CAR T-Cell Therapy in Part 2 of this 13-part series. For more information visit www.asco.org/supportive-care-guidelines   TRANSCRIPT [MUSIC PLAYING] SPEAKER: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. [MUSIC PLAYING]   BRITTANY HARVEY: Hello, and welcome to the ASCO Guidelines podcast series brought to you by the ASCO Podcast Network. A collection of nine programs covering a range of educational and scientific content, and offering enriching insight into the world of cancer care. You can find all the shows, including this one, at asco.org/podcasts. My name is Brittany Harvey, and today we're continuing our series on the management of immune-related adverse events. ASCO has developed two guidelines for the management of immune-related adverse events-- one for patients treated with immune checkpoint inhibitor therapy and a second for patients treated with CAR T-cell therapy. In our last episode, you heard an overview of the Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: ASCO Guideline Update. Today, we'll be focusing on the Management of Immune-Related Adverse Events in Patients Treated with Chimeric Antigen Receptor T-Cell Therapy: ASCO Guideline, and we'll have authors join us for future episodes to discuss the key recommendations for organ-specific management for patients treated with immune checkpoint inhibitor therapy. Today, I am joined by Dr. Monalisa Ghosh, from the University of Michigan Health System in Ann Arbor, Michigan and Dr. Bianca Santomasso from Memorial Sloan Kettering Cancer Center in New York, New York, authors on both Management of Immune-Related Adverse Events in Patients Treated with Chimeric Antigen Receptor T-Cell Therapy: ASCO Guideline and Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: ASCO Guideline Update. Thank you both for being here, Dr. Ghosh and Dr. Santomasso. In addition, I'd like to note that ASCO takes great care in the development of its guidelines and ensuring that the ASCO Conflict of Interest policy is followed for each guideline. The full Conflict of Interest information for this guideline panel is available online with the publication of the guidelines in the Journal of Clinical Oncology. Dr. Ghosh, do you have any relevant disclosures that are directly related to this guideline? MONALISA GHOSH: No. I do not have any relevant disclosures. BRITTANY HARVEY: Thank you. And, Dr. Santomasso, do you have any relevant disclosures that are directly related to this guideline? BIANCA SANTOMASSO: Yes. I'd like to disclose that I've served as a paid consultant for Celgene, Janssen Pharmaceutical, and Legend Biotech for advising them on the topics of CAR T-cell therapy side effects. BRITTANY HARVEY: Thank you. Then, getting into these immune-related adverse events-- first, Dr. Ghosh, can you give us an overview of the scope and purpose of this guideline? MONALISA GHOSH: Sure. The purpose of this guideline is to offer expert guidance and recommendations on the management of immune-related adverse events in patients treated with chimeric antigen receptor or CAR T-cell therapy. This guideline offers guidance on the diagnosis, evaluation, and management of the most common toxicities of CAR T-cell therapy, which includes Cytokine Release Syndrome-- or CRS-- and immune effector associated neurologic syndrome-- or ICANS. As well as other potential, but less common toxicities, such as Hemophagocytic Lymphohistiocytosis-- or HLH-- B-cell aplasia, prolonged and recurrent cytopenias, Disseminated Intravascular Coagulation-- or DIC-- and infections. BRITTANY HARVEY: Great. Thank you. Then, Dr. Santomasso-- looking at this guideline, there's a few overarching recommendations. So, what are those general recommendations for the management of immune-related adverse events in patients receiving CAR T-cell therapy? BIANCA SANTOMASSO: Yes. The overarching recommendations are, really, first to recognize that these side effects exist. And that, as such, it's important to recognize that patients who develop these toxicities or side effects after CAR T-cell therapy need to be evaluated, or managed in, or transferred to a specialty center that has experience with the management of these toxicities. They're new toxicities. This is a new therapy. And patients are increasingly going to be managed in, or treated in, the outpatient setting, and, as such, they need to remain within a short distance of the treating center for about four to eight weeks post-therapy, and they should then return to their treating center upon experiencing any toxicities. Finally, as its flu season and infection season, it is recommended that inactivated influenza and COVID-19 vaccination be performed on patients and also family members as well. And any patient who does have an active infection, the CAR T-cell infusion should be delayed until that infection has been successfully treated or controlled. I often make a final point, which is that the immunogenicity of and efficacy of COVID-19 vaccines is uncertain in these patients with these agents, but the potential benefits outweigh the risks and uncertainties for most patients. BRITTANY HARVEY: Thank you. Those are important points for patients and treating clinicians. So then, Dr. Ghosh-- as you mentioned, this guideline addresses the seven most common CAR-T-related toxicities, and I'd like to review the key recommendations for each of those. So let's start with, what are the key recommendations for identification, evaluation, and management of cytokine-release syndrome? MONALISA GHOSH: Well, Cytokine Release Syndrome is one of the two major toxicities that occur immediately or within a short time period after infusion of CAR T-cells. We have defined Cytokine Release Syndrome, or CRS, as an immune-mediated phenomenon that's characterized by various symptoms that are indicative of immune activation and inflammation. And patients may experience signs and symptoms that could include fever, hypotension, hypoxia, tachycardia, shortness of breath, rash, nausea, headache, and various other symptoms that are a little less common. These symptoms are caused primarily by the release of cytokines. Cytokines are the messengers of the immune system, and most of them are released by bystander immune and non-immune cells. We know that the onset of Cytokine Release Syndrome is variable depending on the CAR T-cell product that's used, as well as the patient population that's treated. But it generally occurs anywhere from two to seven days after infusion of CAR T-cells, and in some rare cases can occur even a little bit later. A standard grading system has been developed and grade CRS, or Cytokine Release Syndrome, based on three parameters-- fever, hypotension, or low blood pressure; and hypoxia or low oxygen levels. CRS is primarily managed with IL-6 antagonists because IL-6 is an inflammatory cytokine that has been shown to mediate a lot of the systemic effects that we see from Cytokine Release Syndrome. And one of the treatments is the monoclonal antibody tocilizumab, which acts against-- or blocks-- the IL-6 receptor. CRS that is refractory to tocilizumab is generally treated with steroids. Then there's limited experience with additional therapies, especially in the setting of CRS, that does not respond to tocilizumab or steroids. There are other anti IL-6 therapies available. For example, siltuximab, which binds to IL-6 itself rather than the IL-6 receptor. However, there have been no direct comparative studies of these agents. Anakinra, which is also an IL-1 receptor antagonist has also been shown to mitigate CRS in some CAR T-cell recipients that have high grade CRS. BRITTANY HARVEY: OK. Thank you for reviewing those management strategies. So, following that-- Dr. Santomasso, what are key recommendations for identification, evaluation, and management of immune effector cell-associated neurotoxicity syndrome? BIANCA SANTOMASSO: Sure. Immune Effector Cell-associated Neurotoxicity Syndrome-- also known as ICANS-- is the second most frequent severe toxicity that can be seen after CAR T-cell therapy. So, what is ICANS? These are transient neurological symptoms that occur in the days after infusion, most commonly with CD19 CAR T-cell therapy. And the clinical manifestations of ICANS include encephalopathy, which is confusion, behavioral changes, expressive aphasia, or other language disturbance, change in handwriting or other fine motor impairment or weakness, and tremor and headache can also be seen. In more severe cases, patients can become obtunded with a depressed level of consciousness or even develop seizures, and they may require a higher level of ICU care, such as intubation for airway protection. And in very rare cases, malignant cerebral edema may develop, which may be fatal. ICANS can occur at the same time as Cytokine Release Syndrome, or can also occur several days after or shortly after CRS resolves, so it's important to have a high index of suspicion even after Cytokine Release Syndrome has resolved, but typically the side effects are self-limited and occur within the one month after infusion. Most symptoms lasts between 5 and 17 days, and the time of onset duration and severity of ICANS may really vary depending on the CAR T-cell product used or the disease state of the patient. So, what do I mean by that? Patients with high disease burden seem to be at increased risk for severe ICANS, so kind of knowing the disease that the patient has and the burden of disease is important. And then also there may be product-specific differences as well, so reviewing the product label is important as well because each may have its own risk evaluation and mitigation strategies that inform both the duration and the frequency of monitoring for ICANS after infusion. For evaluation of ICANS, we recommend, again, the ASTCT ICANS grading system. These allow for monitoring of several different aspects of neurologic function in these patients. Mental status changes are really what define the onset of ICANS. So for CRS, it's fever; for ICANS, it's mental status changes. And the severity of the mental status change can be determined by a standardized score known as the ICE score, which stands for Immune Effector Cell-associated Encephalopathy score. This is a simple 10-point scoring metric where points are assigned for orientation to year, month, city, hospital, ability to name three objects, ability to follow simple commands, write a standard sentence, and count backwards from 100 by tens. And for children younger than age 12 or those with developmental delay, The Cornell Assessment of Pediatric Delirium, also known as the CAPD, can be used in placement of the ICE assessment. Prior to CAR infusion, patients should be evaluated, including with an ICE score, for their baseline neurologic status. And what's nice is that this ICE assessment can be used as a daily screen after CAR infusion for the onset of ICANS during at-risk period. Then, other than the ICE score, there are four other neurologic domains that contribute to ICANS grading, and that's level of consciousness, seizures, severe motor weakness, and signs and symptoms of elevated intracranial pressure or cerebral edema, and patients are graded according to the most severe symptom in any of the five domains. So for patients who develop ICANS, it's recommended that they have workup, including blood work, CRP, CBC, comprehensive metabolic panel, fibrinogen, and coagulation tests. Neuroimaging with a non-contrast CT of the brain should be done and considering MRI of the brain in patients who are stable enough. In addition, electroencephalogram and lumbar puncture should be considered. And the electroencephalogram is really to rule out subclinical seizures, and the lumbar puncture is to assess the opening pressure-- or the pressure within the central nervous system-- and also to send studies to rule out infection. And again, these all have to be considered on an individual case by case basis, but are things to keep in mind. So for treatment of ICANS, the mainstay of treatment is, really, supportive care and corticosteroids. Tocilizumab, while it seems to rapidly resolve Cytokine Release Syndrome and most symptoms, actually does not resolve ICANS and may worsen it, so steroids are really typically used. The typical steroid is dexamethasone at a dose of 10 milligrams, and the interval really depends on the grade of the ICANS. Because of the possibility that tocilizumab may worsen neurotoxicity, ICANS really takes precedence over low grade CRS when the two occur simultaneously. And patients who don't show improvement within 24 hours after starting steroids or other supportive measures should have CSF evaluation and neuroimaging. Often treatment of seizures-- many patients are put on Keppra and levetiracetam or other anti-seizure medicine if they develop ICANS, and patients with grade 3 or greater ICANS may need an ICU level of care and escalation of steroid doses. The steroids are continued until ICANS improves to grade 1 and then tapered as clinically appropriate. And the most important thing to remember is that ICANS just needs to be monitored very closely as patients may worsen as some steroids are tapered. They also may improve rapidly after steroids are started, so steroids should be tapered quickly as patients improve. And, again, as with CRS, there's limited experience with other agents, such as Anakinra and siltuximab, but those could be considered in severe or refractory cases. BRITTANY HARVEY: Understood. I appreciate you going through when and how clinicians should screen for ICANS and those key management points. So, in addition to that-- Dr. Ghosh, what are the key recommendations regarding cytopenias? MONALISA GHOSH: So cytopenias can occur post-CAR T-cell infusion, and they can occur either in the early phase or in the later phase after CAR T-cell infusion. Meaning that they can occur early within the first few days to weeks post-CAR T-cell therapy or could even occur months to years later. These cytopenias include anemia, thrombocytopenia, leukopenia, neutropenia. Many patients may present with fatigue, weakness, shortness of breath, lightheadedness, frequent infections, fevers, bruising, and bleeding, and the symptoms usually are consistent with how they would present otherwise with anemia, thrombocytopenia, or neutropenia. Acute cytopenias within three months of CAR T-cell therapy are more common. This is due to usually the lymphodepleting chemotherapy that is administered prior to CAR T-cell therapy. Most patients receive a combination of fludarabine and cyclophosphamide prior to CAR T-cell infusion, or they may receive another agent, such as bendamustine. Most patients also come into CAR T-cell therapy with low lymphocyte counts from previous therapies. Early cytopenias, as I mentioned, are generally due to lymphodepleting chemotherapy or other recent therapies. There also could be an immune-mediated process due to the CAR T-cells. Usually prolonged cytopenias which occur beyond three months post-CAR T-cell infusion can be seen in a small number of patients. And the mechanism of prolonged cytopenias is really unclear at this time, but likely multifactorial. Most recipients of CAR T-cells who have prolonged cytopenias beyond three months post-CAR T-cell infusion should have a standard workup to rule out other common causes, such as vitamin or nutritional deficiencies. They should also have testing such as bone marrow biopsy and scans to rule out relapse disease-- relapse lymphoma or leukemia, for instance, that could be causing these cytopenias. Other examples would be myelodysplastic syndrome or other bone marrow failure syndromes. So cytopenias are generally managed with supportive care including growth factor and transfusion support. This applies to both cytopenias in the early period post-CAR T-cell therapy or more delayed prolonged cytopenias. In patients who have prolonged cytopenias of unclear cause that could be immune-mediated, other interventions such as high dose IVIG or even steroids could be considered depending on the situation. For those that have cytopenias in the first few months post-CAR T-cell therapy, generally they are monitored and treated with supportive care, and these cytopenias eventually resolve in the majority of patients. BRITTANY HARVEY: Great. Those are important considerations. Then, Dr. Santomasso, what are the key recommendations regarding Hemophagocytic Lymphohistiocytosis? BIANCA SANTOMASSO: The major recommendations for the identification, evaluation, and management of Hemophagocytic Lymphohistiocytosis, or HLH-- this is also known as macrophage activation syndrome. First, let's just start by saying that this is a dysfunctional immune response, and it's basically characterized by macrophages which are revved up and hyperactive and also possibly lymphocytes as well. There are high levels of pro-inflammatory cytokines during this state and tissue infiltration, and hemophagocytosis, and organ damage. This can occur outside of the context of CAR T-cell therapy, either as a primary HLH or secondary HLH that can be either triggered by infections, or autoimmune disease, or cancer-- especially hematological malignancies, but HLH has also been observed as a rare complication of CAR T-cell therapy. And outside of the setting of CAR T-cell therapy, HLH is defined by fever, cytopenias, hyperferritinemia-- or high ferritin level-- as well as bone marrow hemophagocytosis. And what's interesting is that this is very similar to what's seen during Cytokine Release Syndrome, and that can make it difficult for patients who have moderate to severe CRS to distinguish that from HLH. The laboratory results may be very similar. So the key to recognizing HLH is really to have it on your differential even though it occurs rarely after CAR T-cell therapy. It may occur with slightly different timing and may require more aggressive treatment. The lab alterations can include, again, as I mentioned, these elevated levels of several cytokines, such as interferon gamma. We can't normally send those in the hospital or the clinic, but sometimes soluble IL-2 receptor alpha can be sent and serum ferritin can be sent, and that's an especially useful marker. There have been diagnostic criteria for CAR T-cell-induced HLH that have been proposed, and these conclude very high ferritin levels-- over 10,000-- and at least two organ toxicities that are at least grade 3, such as transaminitis, increased bilirubin, renal insufficiency or oliguria, or a pulmonary edema, or evidence of hemophagocytosis in bone marrow or organs. Unlike other forms of HLH that occur outside of the context of CAR T-cell therapy, the patients may not have hepatosplenomegaly, lymphadenopathy, or overt evidence of hemophagocytosis. So just because a patient may not show those yet doesn't mean that HLH shouldn't be considered. If we see patients that have a persistent fever without an identified infection source or worsening fever, we basically should be considering HLH and doing the appropriate workup and treatment. Patients with HLH often have low fibrinogen, high triglycerides, and also cytopenias as well. The treatment-- just as there's an overlap kind of in the signs and symptoms, the treatment and the clinical management overlaps as well with CRS, so tocilizumab is typically administered. But corticosteroids should really be added for these patients, especially if there's clinical worsening or grade 3 or greater organ toxicity. And if there's insufficient response after 48 hours of corticosteroid therapy plus tocilizumab, many centers consider adding another medication such as Anakinra. I'll finally make a comment that, outside of the context of CAR T-cell therapy, HLH is sometimes treated with cytotoxic chemotherapy, such as etoposide. This approach generally is not used as a first line for patients undergoing CAR T-cell therapy due to etopiside's documented toxicity to T lymphocytes. And generally, the corticosteroids, plus the anti IL-6 agent, plus Anakinra is considered the first line of management. BRITTANY HARVEY: Got it. That's an important note on the management of HLH, and a great note on distinguishing CRS and HLH. So in addition, Dr. Ghosh-- what are the recommendations for management of B-cell aplasia? MONALISA GHOSH: B-cell aplasia, it's a disorder that's caused by low numbers or absent B-cells. And this is particularly relevant to CD19 directed CAR T-cell therapy, which is what most of the CAR T-cell therapies that are available right now target. They target CD19, and CD19 is present on normal as well as malignant B-cells. So most patients who receive anti-CD19 CAR T-cell therapy will develop B-cell aplasia at some point, and B-cell aplasia may be temporary or prolonged. It usually does, on one hand, indicate ongoing activity of the CD19 CAR T-cells and can be used as a surrogate marker. And increase in CD19 CAR T-cells could, in some patients, signal impending relapse, or dysfunction, or absence of activity of CD19 CAR T-cells. B-cell aplasia in CAR T-cell recipients is really due to, as I mentioned, an on-target, off-tumor effect. It can be prolonged and there is variability in rates of prolonged B-cell aplasia. The most significant consequence of B-cell aplasia is that it can lead to low immunoglobulin production. And immunoglobulin production is a very important part of the immune response by providing antibody-mediated immunity, so patients may present with frequent infections and low immunoglobulin levels. For most CAR T-cell recipients, this can be managed with infusions of Intravenous Immunoglobulins-- IVIG. However, the presence of B-cell aplasia can also present other challenges-- especially during this current pandemic, as Dr. Santomasso alluded to earlier, that it is unclear if patients will be able to mount a sufficient enough antibody response to the COVID-19 vaccines available since they cannot produce significant amounts of antibodies. This is an active area of research. However, we do advise that all CAR T-cell recipients do get the COVID vaccine and also other seasonal vaccines, such as the influenza vaccine. So it remains to be seen. We need some more long-term follow-up studies on how many people who receive CD19-directed CAR T-cell therapy will have prolonged B-cell aplasia and what the consequences will be. At this time, it is suggested that patients have their IgG levels monitored and-- if possible-- their actual B-cell numbers monitored. And if their IgG levels drop below a certain number, then they may receive IVIG infusions intermittently. We recommend in this guideline using 400 as a possible cutoff for IgG levels prior to administering IVIG. However, if patients have higher IgG levels and they have recurrent or life threatening infections, infusion of IVIG is recommended as a consideration to help boost the antibody response. BRITTANY HARVEY: OK. As you mentioned, those challenges are particularly relevant now. So then, Dr. Santomasso, what are the key recommendations regarding Disseminated Intravascular Coagulation? BIANCA SANTOMASSO: Disseminated Intravascular Coagulation is a disorder that's characterized by systemic pathological activation of blood clotting mechanisms, which results in both clot formation throughout the body and also bleeding. There's an increased risk of hemorrhage as the body is depleted of platelets and other coagulation factors. So it's basically important for clinicians to be aware that DIC-- or Disseminated Intravascular Coagulation-- can occur after CAR T-cell therapy, and it can occur either with or without concurrent Cytokine Release Syndrome. The treatment is primarily supportive care and replacing the factors, such as fibrinogen-- based on the levels-- and also replacing factors based on partial thromboplastin time and bleeding occurrences. But corticosteroids and IL-6 antagonist therapy can be used if there is concurrent CRS or in the setting of severe bleeding complications. There is limited evidence for other interventions. BRITTANY HARVEY: Great. Appreciate you reviewing those. So then, the last category of toxicity addressed in this guideline-- Dr. Ghosh, what are the key recommendations for identification, evaluation, and management of infections? MONALISA GHOSH: So a variety of infections can be seen after CAR T-cell therapy. And there are many factors that can lead to infection after CAR T-cell therapy including the presence of cytokines, such as neutropenia or leukopenia and B-cell aplasia that we earlier discussed-- leading to low immunoglobulin production and protection. As well as the increased risk of infection due to use of high-dose steroids to treat CAR T-cell-related toxicities, such as ICANS or CRS. Early after the infusion of CAR T-cell therapy-- that is, within three months-- patients often develop neutropenia due to lymphodepleting chemotherapy and/or the CAR T-cells themselves. And these patients are particularly susceptible to infection, so most of the infections that occur early on tend to be bacterial infections, and a few fungal infections have been observed as well. Patients who receive high-dose steroids for high grade CRS or ICANS have been shown to have increased serious infectious complications including bacterial infections, fungal infections, as well as viral reactivations. Infectious complications that occur later are often due to hypogammaglobulinemia due to B-cell aplasia and reduced production of immunoglobulins. And treatment is typically directed at the infectious source, as it would be even if these patients did not have CAR T-cell therapy. There are some prophylactic antimicrobials that are recommended for CAR T-cell recipients who have prolonged cytopenias. Especially those with prolonged neutropenia should be on some sort of bacterial and/or fungal prophylactic antimicrobials. Patients should also be monitored for hypogammaglobulinemia long term and should receive intravenous immunoglobulins as needed. As we have mentioned a couple of times already, being very aware that these patients are also more susceptible to seasonal infection, such as influenza, is important, and so vaccinations are very important for this patient population. Vaccinating against influenza and vaccinating against COVID-19. BRITTANY HARVEY: Thank you both for reviewing those key points for the most common CAR T-related toxicities. So, just to wrap us up-- Dr. Santomasso-- in your view, how will this guideline impact both clinicians and patients? BIANCA SANTOMASSO: Well, I think we've seen now that cell therapy is really one of the major advances in cancer treatment in the past decade. And I think it's reasonable to expect more of these cell therapies to be developed, and we'll hopefully see their use extend beyond very specialized centers. But CAR T-cell therapy side effects are manageable if they're recognized, so I think this guideline helps that, and they're reversible with proper supportive care. They can be serious and they require close vigilance and prompt treatment. But, again, we believe this guideline and recommendations will help members of clinical teams with both the recognition and management of all of these toxicities, and that will help patients by increasing their safety. BRITTANY HARVEY: Great. That's important to note that these toxicities can be severe, but are also manageable. So I want to thank you both for your work on these guidelines and for taking the time to speak with me today, Dr. Santomasso and Dr. Ghosh. BIANCA SANTOMASSO: Our pleasure. MONALISA GHOSH: Absolutely. It was my pleasure. BRITTANY HARVEY: And thank you to all of our listeners for tuning in to the ASCO Guidelines podcast series. Stay tuned for additional episodes on the management of immune-related adverse events in patients treated with immune checkpoint inhibitors. To read the full guidelines, go to www.asco.org/supportive care guidelines. You can also find many of our guidelines and interactive resources in the free ASCO Guidelines app available in iTunes or the Google Play store. If you have enjoyed what you've heard today, please rate and review the podcast, and be sure to subscribe so you never miss an episode. [MUSIC PLAYING]

Infectious Groove Podcast
A Long Way Back To "Normal"

Infectious Groove Podcast

Play Episode Listen Later Nov 1, 2021 52:25


I think we can all agree that it's been one hell of a covid induced roller-coaster ride over the past couple of years, and one of the industries that felt that the most involved touring musicians. From non-stop touring for years, to closing up shop (what seemed like overnight), while everyone involved in the industry was left scratching their heads. When we started this podcast, we had the idea of being able to talk to you guys about our various concert-going experiences, and that idea quickly became a thought of the past as we watched the world quite literally shut down. It seemed as if our idea had been put to rest before we even had the chance to take a crack at it. Fast forward to now, and as things slowly start their ascent back to "normalcy", we've started seeing the long-awaited return of live music. One of the most challenging things about this is trying to navigate the new "normal" that has become venturing to a live music venue. Russ has found out that the more you do it, the easier it gets. But it's hard to get back in the swing of things after something like a global pandemic. The entire thing kind of sits in the back of your head and as soon as you get around people, you become uneasy almost automatically without even thinking about it. So how do we navigate this still very sensitive and unknown landscape of post-pandemic concerts? We're as unsure as all of you, but there is no way in hell we're going to sit here and not try and figure it out. If you're ready, we're ready. Will the industry be the"same"? Probably not. Will we get back to where we once were? We will undoubtedly be someplace similar—hopefully sooner, rather than later, but truthfully only time will tell. Though things will likely play out differently than they once did, that doesn't mean that different is bad. Change can be good, even if it isn't a change you saw coming. Plus, maybe Kyle will get his wish and people will finally stay the hell away from him at shows. It's season 4, episode 18 of your favorite band's, favorite sound guy's, favorite music podcast. LET'S GO!!! Keep up with all of the music we talk about in each episode by listening to the Infectious Groove Podcast Companion Songs playlist, exclusively on Spotify. Infectious Groove Podcast, part of the OddPods Media Network.

Enthutheist Devotional Podcast
Episode 86: Infectious, "What Can" we learn from "What if...?" Chapter 5

Enthutheist Devotional Podcast

Play Episode Listen Later Oct 31, 2021 6:03


Happy Holoween! Just as promised here is an episode with walking corpses How can something that defies the real Resurrection teach us about the our Christian Lives This episode gives special thanks to Ron Young  Follow us on Twitter and Instagram @enthutheist 

Cork's 96fm Opinion Line
PODCAST EXTRA - Vaccinated Are Still Infectious

Cork's 96fm Opinion Line

Play Episode Listen Later Oct 29, 2021 13:15


Infectious Diseases physician Dr Anika Singanayagam tell PJ Coogan the findings of a study of COVID-19 transmission between household contacts, led by Imperial College London.It finds that people who have received two doses of vaccine still have the risk of becoming infected with the delta variant in the home compared with people who are unvaccinated. See acast.com/privacy for privacy and opt-out information.

Smooth Jazz Weekend Radio Podcast
Smooth Jazz Weekend with Tina E. (My Heart Is Yours)

Smooth Jazz Weekend Radio Podcast

Play Episode Listen Later Oct 26, 2021 60:00


Pleasing to the ear! InFecTious! A blast from the past, sure to conjure up memories of good times and good vibes. Certainly the soundtrack to your WEEKEND! Enjoy! Set 1: Kim Scott ft. Althea Rene & Ragan Whiteside-I'm Every Woman Justin Lee Schultz-Do I Do Doc Powell-Love On Top Gerald Albright ft. Norman Brown-Champagne Life Bob Baldwin-I Wanna Be Where You Are Set 2: Nathan Mitchell-My Heart Is Yours Jesse Adams Jr.-Missing You Andre Ward-Heaven In MY Life Art Sherrod-Breakin' My Heart Ben Tankard-How Deep Is Your Love Set 3: Kyle Turner-Evening Falls Jason D. Jordan-After Dark Michael Ward-After The Kiss

Smooth Jazz Weekend Radio Show
Smooth Jazz Weekend with Tina E. (My Heart Is Yours)

Smooth Jazz Weekend Radio Show

Play Episode Listen Later Oct 26, 2021 60:00


Pleasing to the ear! InFecTious! A blast from the past, sure to conjure up memories of good times and good vibes. Certainly the soundtrack to your WEEKEND! Enjoy! Set 1: Kim Scott ft. Althea Rene & Ragan Whiteside-I'm Every Woman Justin Lee Schultz-Do I Do Doc Powell-Love On Top Gerald Albright ft. Norman Brown-Champagne Life Bob Baldwin-I Wanna Be Where You Are Set 2: Nathan Mitchell-My Heart Is Yours Jesse Adams Jr.-Missing You Andre Ward-Heaven In MY Life Art Sherrod-Breakin' My Heart Ben Tankard-How Deep Is Your Love Set 3: Kyle Turner-Evening Falls Jason D. Jordan-After Dark Michael Ward-After The Kiss

Voices of Misery Podcast
Harvard educated children‘s author, Bracha Goetz joins the show and spreads her infectious positivity.

Voices of Misery Podcast

Play Episode Listen Later Oct 26, 2021 84:53


Bracha Goetz graduated from Harvard University, attended the Medical College of Virginia, and went on to study at Ohr Someyach Women's Division in Jerusalem. She is blessed with a bunch of beautiful children and grandchildren, is the author of several children's books, an editor of books for women, a frequently published poet, and the Mentoring Coordinator of the Jewish Big Brother and Big Sister League in Baltimore. @BrachaGoetz https://www.amazon.com/Bracha-Goetz/e/B001KCI086 Twitter: @voicesofmisery mewe: @voicesofmisery Parler: voices of misery Gmail: voicesofmiserypodcast@gmail.com Instagram: voicesofmiserypodcast Discord server: voices of misery podcast https://tinyurl.com/VoMPodcastTees

The Daily Good
Episode 396: A carbon-negative perfume, a great quote from Mark Twain, a classic old restaurant in Los Angeles, your weekly joke, the infectious music of Louis Jordan, and more…

The Daily Good

Play Episode Listen Later Oct 25, 2021 17:17


Good News: An innovative company has created the world’s first “carbon negative” perfume and is bringing it to market soon! Link HERE. The Good Word: A classically sardonic quote from Mark Twain… Good To Know: A fascinating group of facts about John Adams, Thomas Jefferson, and their deaths! Good News: A university researcher is creating […]

Infectious Groove Podcast
IGP Crew Album Review: Elvis - As Recorded at Madison Square Garden

Infectious Groove Podcast

Play Episode Listen Later Oct 25, 2021 54:53


Live albums aren't for everyone, and if you want to get technical, some might say Elvis isn't either. I'm not sure who those people are, but I'm sure they're out there somewhere. Regardless of what you think about Elivs, live music is something that he did exceptionally well, and if you're looking to get into listening to live recorded music, this might be a proper place to start, A majority of artists might go their entire music career without playing Madison Square Garden. Even fewer artists have the ability to sell out Madison Square Garden when and if they get the chance to play it. Elvis not only sold out Madison Square Garden, but he sold it out five times in two days, and then put out two different live albums from the events, and by putting them out I mean he released one of them literally eight days after the show—which even in modern times is completely unheard of. Released in June of 1972, the album was met with much acclaim which helped the album peak at number 11, on the Top 200 US Billboard Albums Chart by August of the same year. The concert and subsequent albums were promoted as being Elvis' first live concerts in NYC since the 1950s, so to say that these shows and the two albums that came from them were a big deal, is certainly an understatement. Despite what appears to be a rather lengthy tracklisting, the release only made its way onto one double-sided LP. Much later on, Evlis' drummer Ronnie Tutt would shed a little light on why this might have been sighting that "The Colonel" Elvis' manager had the mixes sped up so that more songs could fit on the album, increasing his song royalties.Elvis, As Recorded at Madison Square Garden would go on to be certified Gold in August of 1972, Platinum in May of 1988, Double-Platinum in March of 1992, and then Triple-Platinum by July of 1999. This isn't just any live album and if you ask Kyle, he'll tell you that it just might be THE quintessential live album. I guess you can be the judge of that after you come with us as we talk about everything a live Elvis performance has to offer. It's season 4, episode 17 of your favorite music podcast (even if you don't know it yet). LET'S GO!!! Keep up with all of the music we talk about in each episode by listening to the Infectious Groove Podcast Companion Songs playlist, exclusively on Spotify. Infectious Groove Podcast, part of the OddPods Media Network.

gregrainsmedia's podcast
Infectious false religion -- Released 2021-10-24 (Recorded 2021-10-17)

gregrainsmedia's podcast

Play Episode Listen Later Oct 24, 2021 39:08


Infectious false religion I. Golden calf II. Micah's shrine III. Israelites straddled fence IV. Judiazing teachers V. Pergamum church

Radio Health Journal
Endemic Covid: The Disease That Never Leaves

Radio Health Journal

Play Episode Listen Later Oct 24, 2021 18:54


Many experts believe we have missed our chance to eliminate COVID-19, and that now it is very likely to become an endemic disease--one that persists, though at lower levels, and never goes away. Two noted infectious disease experts discuss what that means for precautions and lifestyles in perpetuity.

Conversations With Coleman
Parasites of the Mind with Andy Norman [S2 Ep.34]

Conversations With Coleman

Play Episode Listen Later Oct 23, 2021 76:52


My guest today is Andy Norman. Andy is a philosopher and the director of the humanism initiative at Carnegie Mellon University. He is also the founder of CIRCE, the Cognitive Immunology Research Collaborative. In this episode, we discuss his new book "Mental immunity: Infectious ideas, Mind parasites, and the Search for a Better Way to Think." We talk about how bad ideas operate like parasites. We talk about the notion of a mental immune system. We talk about the virtues and dangers of being open-minded. We discussed Richard Dawkins's notion of selfish genes and his coinage of the word "Meme". We talked about conspiracy theories, we talked about whether you should seek out disagreements with your friends and family or whether you should simply keep the peace. We talk about policies like stop and frisk and how to weigh lives saved against more abstract moral gains. We talk about what makes good ideas, "good" and bad ideas, "bad". We talk about the Milgram experiment and the Stanford prison experiment. We talk about cultures of cheating and cultures of honesty in different sports, and much more.

Alabama's Morning News with JT
Michael Saag 102221

Alabama's Morning News with JT

Play Episode Listen Later Oct 22, 2021 9:46


Dr. Michael Saag from the Infectious Disease Department at UAB Hospital gives the latest updates on COVID-19, vaccines and the booster shots.

Spectrum | Deutsche Welle
The Delta plus variant

Spectrum | Deutsche Welle

Play Episode Listen Later Oct 20, 2021 11:03


It's been called the "most infectious" variant yet. So what do we know about Delta plus?

Vet Candy Continuing Education
Infectious diseases in cats

Vet Candy Continuing Education

Play Episode Listen Later Oct 20, 2021


This program discusses common infectious diseases of cats including viruses, ringworm, tick borne diseases and heartworm disease, the program is hosted by board certified veterinary criticalist, Dr Carey Hemmelgarn. Topics covered:• Viral causes of infectious disease• Tick borne diseases• Parasitic infectious disease• Prevention of infectious diseases This program is brought to you by Merck AnimalContinue reading "Infectious diseases in cats"

BC Today from CBC Radio British Columbia
B.C. moves to lift restrictions on indoor gatherings and activities; shortage of veterinarians and its impacts

BC Today from CBC Radio British Columbia

Play Episode Listen Later Oct 20, 2021 51:16


B.C. announced it's moving to lift restrictions on indoor events and gatherings, including sporting events, weddings and concerts, but not some activities like dancing. Infectious disease specialist Dr. Brian Conway is here to answer questions. In the 2nd half, B.C. is in "dire need" of more veterinarians, and the the College of Veterinarians of B.C. is sounding the alarm on impacts on mental health of heavy workloads for currently practicing vets.

The Current
Ontario hospital testing monoclonal antibodies as another tool to fight COVID-19

The Current

Play Episode Listen Later Oct 20, 2021 9:56


Infectious disease physician Dr. Zain Chagla explains a pilot project to treat COVID-19 patients with monoclonal antibodies, underway at St. Joseph's Healthcare in Hamilton, Ont.

Afternoon Drive with John Maytham
The new Delta descendant may be more infectious than the original Delta variant

Afternoon Drive with John Maytham

Play Episode Listen Later Oct 19, 2021 7:44


Guest: Professor Francois Balloux joins John to discuss research that is finding alarming evidence that the new delta descendant may be more infectious than the original Delta variant. If the preliminary evidence is confirmed, AY.4.2 may be the most infectious coronavirus strain since the pandemic started.  See omnystudio.com/listener for privacy information.

The Coolness Chronicles® with Ryan Luis Rodriguez
A Substantial Gift/The Broken Promise: “Police Squad!” in Color (featuring Russ from Infectious Groove)

The Coolness Chronicles® with Ryan Luis Rodriguez

Play Episode Listen Later Oct 19, 2021 55:45


This week, we're diving headfirst into another Z-A-Z joint, the six-episode television series "Police Squad!".It's a tale that involves a return to Quinn Martin territory, multiple murdered guest stars, fake freeze-frames, rejected laugh tracks, and yet another instance in which I thank the television gods for canceling a beloved series.Plus, Russ from "Infectious Groove" stops by for a discussion of his podcast and the 1970 documentary "Elvis: That's the Way It Is". Join your wonky yet affable host!This Week's Recommendation(s): “The Gay Divorcee" (1934) and "Top Hat" (1935)For every single episode at least a week early and great WEEKLY bonus episodes, become a Patreon subscriber. For only $5 you can help keep the show alive and enjoy some quality laughs in the process: https://www.patreon.com/coolnesschroniclesTwitter: @coolnesspodryan, Instagram: @thecoolnesschronicles, Facebook: https://www.facebook.com/coolnesspodryan Theme Music by: Bildschirm (bildschirm.bandcamp.com). Artwork by: Lacie Barker.  The clips featured in this podcast were for critical review and parody, which are protected under the Fair Use laws of the United States Copyright Act of 1976. All rights are reserved and acknowledged.Support the show (https://www.patreon.com/coolnesschronicles)

Spotlight Hawaii
Infectious disease expert Tim Brown of the East-West Center joins Spotlight Hawaii

Spotlight Hawaii

Play Episode Listen Later Oct 18, 2021 34:28


Infectious disease expert Tim Brown of the East-West Center joined the Honolulu Star-Advertiser's “Spotlight Hawaii” livestream show today to answer viewer questions. The series shines a spotlight on issues affecting the Hawaiian Islands.

The Pastor's Heart with Dominic Steele
80% opening date for churches brought forward a week in NSW - with Michael Stead

The Pastor's Heart with Dominic Steele

Play Episode Listen Later Oct 17, 2021 27:46


Churches will be free to open for vaccinated and unvaccinated people a week earlier than had been expected in New South Wales. With 80% of NSW adult population fully vaccinated, a new Public Health Order comes into force from Monday 18 October 2021.We talk with South Sydney Anglican Bishop Michael Stead about the implications of the new PHO, contradictions between it and the COVID safe plan, and what to do about ventilation. https://www.nsw.gov.au/form/covid-safety-plan/places-of-worshiphttps://www.nsw.gov.au/covid-19/business/covid-safe-business/ventilationhttps://www.cdc.gov/coronavirus/2019-ncov/more/science-and-research/surface-transmission.htmlhttps://www.health.nsw.gov.au/Infectious/controlguideline/Documents/contact-risk-assessment-business-community-settings.pdf-----Please financially support the Living Faith pastoral ministry by going to http://www.livingfaith.online Support the show (https://www.patreon.com/thepastorsheart)

Highlights from The Hard Shoulder
''Is it better to slow it down over 6 or 8 months?...''

Highlights from The Hard Shoulder

Play Episode Listen Later Oct 15, 2021 7:54


Sam McConkey, Infectious disease specialist with the Royal Colleges of Surgeons Ireland joined Kieran on The Hard Shoulder... The Hard Shoulder Listen and subscribe to The Hard Shoulder on Apple Podcasts, Google Podcasts and Spotify.      Download, listen and subscribe on the Newstalk App.     You can also listen to Newstalk live on newstalk.com or on Alexa, by adding the Newstalk skill and asking: 'Alexa, play Newstalk'.

Ask the Naked Scientists Podcast
Are farts infectious?

Ask the Naked Scientists Podcast

Play Episode Listen Later Oct 15, 2021 26:56


This week, James Croll and Mulitun Milankovic's contributions to planetary climate cycles; what it takes to knock a planet off-axis; where do clouds falling off Table Mountain go; does a discharged battery weigh less than a charged battery; the cheese reaction and bad dreams; why some foods go through undigested; why are planets round; birds recognising their own flocks; Captain Kirk heads to space; is a bad smell potentially infectious? Lester Kiewit and Dr Chris have the answers... Like this podcast? Please help us by supporting the Naked Scientists

Ask the Naked Scientists
Are farts infectious?

Ask the Naked Scientists

Play Episode Listen Later Oct 15, 2021 26:56


This week, James Croll and Mulitun Milankovic's contributions to planetary climate cycles; what it takes to knock a planet off-axis; where do clouds falling off Table Mountain go; does a discharged battery weigh less than a charged battery; the cheese reaction and bad dreams; why some foods go through undigested; why are planets round; birds recognising their own flocks; Captain Kirk heads to space; is a bad smell potentially infectious? Lester Kiewit and Dr Chris have the answers... Like this podcast? Please help us by supporting the Naked Scientists

NYLO Music
SixxFoot - Aiyana (Extended Mix) | NYLO NY022X

NYLO Music

Play Episode Listen Later Oct 15, 2021 5:23


NYLO is excited to welcome back British sensation SixxFoot. The duo returns after their last outing hit the number 1 spot across the board in Beatport confirming their status as the next big thing. SixxFoot's sound profile resonates throughout their original music which is upbeat, atmospheric with some great vibes and iconic fills. It's fun with summertime feelings always shining thru that will help you get up and get a move on. Their latest EP comprises of 2 forward-thinking, feel-good UK house inspired, cut up house tracks. SixxFoot get us going with 'Boogieland' a moody and groovy driven tune with a cheeky vibe that leaves a long-lasting impression and will get any dance floor thrilled. 'Boogieland' is a perfect example of how SixxFoot is able to revitalize dated sounds and give them new shine, adding a stunning Jupiter 8 like synth bassline combined with a long ethereal pad, which rounds off the release perfectly and feels like the monumental end to a great night out. Next up is the title track 'Aiyana'; which delivers a totally tantalizing creation of temperamental basslines, supernatural electric wizardry, seductive echoing and a rocking piano. Showing off SixxFoot's signature soaring synths and lust-filled melodies that make for an Infectious blend of romance and debauchery. 'Aiyana' is dance floor gold in the purest sense, making it a ground-breaking soundtrack for the summer, which should not be missed! The dynamic duo definitely delivered another weapon with Boogieland; just close your eyes and get carried away by the exotic house rhythms of that will make you dance literally, like there is no tomorrow. SixxFoot's 'Boogieland' sees a worldwide release on October 11th, 2021 via all well-known digital content providers. Catalog #NY022X Release Date: September 20th, 2021 © 2021 NYLO. All Rights Reserved. For more information or news please visit: www.nylolab.com

NYLO Music
SixxFoot - Boogieland (Extended Mix) | NYLO NY022X

NYLO Music

Play Episode Listen Later Oct 15, 2021 5:41


NYLO is excited to welcome back British sensation SixxFoot. The duo returns after their last outing hit the number 1 spot across the board in Beatport confirming their status as the next big thing. SixxFoot's sound profile resonates throughout their original music which is upbeat, atmospheric with some great vibes and iconic fills. It's fun with summertime feelings always shining thru that will help you get up and get a move on. Their latest EP comprises of 2 forward-thinking, feel-good UK house inspired, cut up house tracks. SixxFoot get us going with 'Boogieland' a moody and groovy driven tune with a cheeky vibe that leaves a long-lasting impression and will get any dance floor thrilled. 'Boogieland' is a perfect example of how SixxFoot is able to revitalize dated sounds and give them new shine, adding a stunning Jupiter 8 like synth bassline combined with a long ethereal pad, which rounds off the release perfectly and feels like the monumental end to a great night out. Next up is the title track 'Aiyana'; which delivers a totally tantalizing creation of temperamental basslines, supernatural electric wizardry, seductive echoing and a rocking piano. Showing off SixxFoot's signature soaring synths and lust-filled melodies that make for an Infectious blend of romance and debauchery. 'Aiyana' is dance floor gold in the purest sense, making it a ground-breaking soundtrack for the summer, which should not be missed! The dynamic duo definitely delivered another weapon with Boogieland; just close your eyes and get carried away by the exotic house rhythms of that will make you dance literally, like there is no tomorrow. SixxFoot's 'Boogieland' sees a worldwide release on October 11th, 2021 via all well-known digital content providers. Catalog #NY022X Release Date: September 20th, 2021 © 2021 NYLO. All Rights Reserved. For more information or news please visit: www.nylolab.com

Microbe Talk
Episode 125: Infectious: Pathogens and How We Fight Them

Microbe Talk

Play Episode Listen Later Oct 13, 2021 12:54


COVID-19 has put the subject of infections and pathogens firmly on the centre stage. But it can be difficult to know where to go to find information that is easy to understand and that you can trust. This week Matt talks to Dr Tregoning, author of ‘Infectious: pathogens and how we fight them', a book that gives a fascinating overview of our ongoing fight against pathogens, uncovering success stories in immunology and virology, and providing some hope in these uncertain times.

Repicture – A podcast of The Everyday Projects
Courage is infectious: Standing up to sexual harassment

Repicture – A podcast of The Everyday Projects

Play Episode Listen Later Oct 13, 2021 50:11


When we ourselves become victims of sexual harassment and abuse, how do we navigate the process of speaking out? How can we support each other and build a safer industry? And just how inclusive has the #MeToo movement been? In this episode of Repicture, cohosts Tasneem Alsultan and Nyasha Kadandara discuss the sexual harassment of women within the visual journalism industry. Featuring Anastasia Taylor-Lind, Kristen Chick and Tanvi Mishra

Let’s Go There with Shira & Ryan
10/12 Make America Great Again, Again?

Let’s Go There with Shira & Ryan

Play Episode Listen Later Oct 13, 2021 72:49


As airlines were hit with tons of cancellations over the weekend should we expect more? We get into the latest story to come out of the NFL involving homophobic emails, and our fav. sports reporter joins us! Plus, we highlight the Reverend fighting for anti-trans bills, plus more!    Special guests: Oriana Pawlyk - POLITICO's aviation reporter. Dr. Amesh Adalja -  Infectious disease MD working on pandemic policy, emerging infections, preventing bioterror. Reverend Remington Johnson - Presbyterian minister and healthcare chaplain. Alex Reimer - Digital content producer Audacy Sports. Sian Bradley - Freelance writer interested in mental health, tech, culture + resistance. See omnystudio.com/listener for privacy information.

Radio Boston
Ask The Doctors: Vaccine deadline enforcement kicks in for Boston city workers; A pill for COVID-19?

Radio Boston

Play Episode Listen Later Oct 12, 2021 20:32


Infectious disease experts Dr. Sabrina Assoumou with Boston Medical Center and Dr. Helen Boucher at Tufts Center join us to dig into the latest on the pandemic.

Rock Matters
E69 44 Days in 1991 with Russ from Infectious Groove

Rock Matters

Play Episode Listen Later Oct 5, 2021 81:42


It's time for some rock history! In this episode, The Itch is joined by our friend Russ from the Infectious Groove Podcast to discuss August and September of 1991, aka "two months that changed rock music," capped by the releases from September 24, which has been called the "biggest release day in history." We'll cover classic rock legends maintaining relevance, one of the biggest bands of the 80s carrying their career into another decade, and the rise of grunge and "alternative rock." Enjoy! (Note: During the middle of recording this episode, Dan discovered that Soundgarden's Badmotorfinger was actually released on October 8, 1991, after being delayed from its originally scheduled release date of September 24.) And hey, when you're done, check out the Infectious Groove's pair of episodes on 1991, watch Russ's recent YouTube video about Use Your Illusion, follow our New Rock Roundup playlist, and then connect with us! The Itch gives you homework! itchrocks.com Twitter.com/itchrocks Facebook.com/itchrocks Instagram.com/itchrocks itchrocks@gmail.com Thank you so much for listening. If you like what you hear, please subscribe and leave a positive review and rating on Apple Podcasts or Podchaser to help our audience grow. If you don't like what you hear, please tell us anyway to help our skills grow. Our theme song "Corrupted", is used with permission from the amazing Skindred. All other content is copyright of The Itch. All rights reserved, including the right to rock on.

SBS World News Radio
Is pandemic modelling a crystal ball, foretelling the future?

SBS World News Radio

Play Episode Listen Later Oct 4, 2021 10:48


Infectious disease and vaccine modelling has been vital in informing governments how to shape their coronavirus response.

Public Health On Call
377: An Update on COVID-19 and India

Public Health On Call

Play Episode Listen Later Sep 29, 2021 17:58


Last spring, India experienced a catastrophic wave of COVID-19 infections with more than 100,000 cases per day, exceeding hospital capacity in some areas and leading to oxygen shortages. What has happened since? From their homes in India, infectious disease researchers Dr. Vidya Mave and Dr. Brian Wahl talk with Dr. Josh Sharfstein about the state of the pandemic and the return to daily life.

The Signal
Can we still trust COVID modelling?

The Signal

Play Episode Listen Later Sep 29, 2021 16:28


The big Delta outbreaks in Victoria and NSW are on different trajectories, but this week there was a strange crossover moment. On Tuesday, NSW recorded 863 new COVID cases, while in Victoria the daily tally that day was higher, at 867. In NSW the signs are that the Delta outbreak is finally improving, while in Victoria the case curve remains exponential. So is this what the modelling predicted? And will things get worse or better from here? Today on The Signal, we're looking at what the various models being used by governments predicted would happen, and asking whether we can trust them to forecast the months ahead. Featured: Professor Greg Dore, Kirby Institute, University of NSW and Infectious diseases physician, St Vincent's Hospital, Sydney Professor Margaret Hellard, Deputy Director, Burnet Institute, Melbourne

3 minute lesson
Infectious dose | Epidemiology

3 minute lesson

Play Episode Listen Later Sep 29, 2021 3:00


Episode 369. Topic: Infectious dose. Theme: Epidemiology. How many viruses or bacteria does it take to get you sick? How does this number change? What are some theorized infectious doses for common diseases? What about COVID-19? Twitter: @3minutelessonEmail: 3minutelesson@gmail.comNew episode every Monday, Wednesday, and Friday!

The Daily Crime
"A heart of gold and an infectious smile"

The Daily Crime

Play Episode Listen Later Sep 24, 2021 16:28


There is an update related to the 'Slender Man' stabbing case in Wisconsin, and authorities in North Carolina have announced an arrest in a nine-year-old homicide case. Will and Reed talk through the details of both cases.

Nerdette
The Doctor Is In — Again!

Nerdette

Play Episode Listen Later Sep 17, 2021 19:04


You asked, we delivered! Infectious disease expert Emily Landon is back to take your questions on variants, vaccines, and more.