Health and Medicine (Audio)

Sarah Banks, Ph.D. explores why Alzheimer's disease affects women differently than men, emphasizing distinct patterns in tau pathology, cognitive testing bias, and treatment response. She explains how women tend to show a rapid buildup of tau during early cognitive decline, which may contribute to their higher prevalence of Alzheimer's. Banks also highlights how common diagnostic tools may overlook symptoms in women and how approved treatments may offer less benefit for them. Her research at UC San Diego investigates key sex-based differences in risk factors, including sleep apnea, diabetes, and exercise. One study reveals that over 70% of participating women had undiagnosed sleep apnea. Another focuses on Black women, using blood biomarkers to identify overlooked risks and improve care. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40768]

UCSF researchers June Chan and Stacey Kenfield share evidence-based strategies for improving prostate cancer outcomes through exercise and diet. They highlight studies showing that physical activity—including resistance and high-intensity interval training—is linked to lower risk of prostate cancer progression and death. They discuss plant-based diets, dietary indices, and specific foods like tomatoes, fish, and nuts, along with the benefits of substituting plant oils for butter. Their analysis includes findings on racial disparities and underscores the need for inclusive research. They also describe current clinical trials exploring lifestyle tools and offer guidance on navigating diet and exercise choices during cancer survivorship. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40808]

Dr. Robert Baron reviews best practices in lipid management for preventing cardiovascular disease, with a focus on statin use. He outlines the strong evidence for statins in reducing heart attack and stroke risk by 25–33%, particularly in patients with clinical atherosclerotic disease, diabetes, or high LDL. He explains why shared decision-making is key in primary prevention, where guidelines vary and risk thresholds are debated. Baron discusses the shift to the newer PREVENT risk calculator, which offers improved accuracy and removes race as a factor. He also explains when additional lipid-lowering medications may be appropriate and clarifies the impact of risk-enhancing factors like family history, coronary artery calcium, and LP(a). [Health and Medicine] [Show ID: 40755]

As part of the 2025 Developmental Disabilities Conference, Dr. Mary Dubon of Harvard Medical School talk about adaptive and para sports for youth with physical and developmental disabilities. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 40617]

Jennifer Anger, M.D., M.P.H., Ph.D. investigates interstitial cystitis (IC), also known as painful bladder syndrome, with a focus on improving care through research on sex, gender, and health disparities. Using Veterans Affairs (VA) data, Anger challenges the outdated belief that IC predominantly affects women. She explores how comorbidities such as PTSD and depression, common among veterans, influence bladder pain, and examines how factors like exercisJennifer Anger, M.D., M.P.H., Ph.D. uses VA data to study interstitial cystitis.. She examines links between bladder pain, PTSD, depression, diet, and disparities to improve care across all gender identities.e, diet, and neighborhood deprivation impact symptoms. By including both cis and trans women as well as men, Anger seeks to advance more inclusive, data-driven understanding and treatment of IC across all populations. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40675]

Gladys (Sandy) Ramos, M.D. outlines the comprehensive maternal care services at UC San Diego, emphasizing clinical excellence, innovation, and community impact. She highlights programs in diabetes and pregnancy, high-risk obstetrics, postpartum and HIV care, and maternal mental health. Ramos describes cutting-edge capabilities in fetal and placental imaging, including expertise in placenta accreta and genetic counseling. A fetal surgery program is launching soon, expanding access to specialized care and research. The department's patient population closely reflects San Diego County's demographics, which informs both clinical care and research priorities. Ramos also details a collaborative structure with multidisciplinary conferences and welcomes partnerships in research related to maternal, placental, and fetal health. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40669]

UCLA's Avishek Adhikari, PhD, presents new research on the role of GABAergic neurons in the brain's periaqueductal gray (PAG) region. Previously studied for their involvement in fear and defensive behaviors, these neurons were found to promote food-seeking behavior when activated—even in fully fed mice. Using calcium imaging and optogenetics, Adhikari's team discovered that these neurons are active during food approach but suppressed during eating. The effect is stronger for high-value foods like chocolate or crickets and depends on the mouse's prior experience with that food. A key finding is that these neurons influence behavior through a specific projection to the zona incerta, a subthalamic region. Rather than signaling hunger, this pathway appears to drive food seeking based on reward value, highlighting a new motivational circuit in the brain. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40444]

Sheng Zhong, Ph.D. pioneers technologies that advance women's reproductive health. Zhong develops a minimally invasive method to analyze extracellular RNA secreted by embryos during IVF. By sequencing tiny samples of spent culture media, they generate comprehensive RNA profiles and use machine learning to identify biomarkers that predict embryo quality with accuracy comparable to traditional imaging. This breakthrough offers a gentler, data-driven alternative for assessing embryo viability, with the potential to improve live birth rates and support families navigating infertility. Zhong's research highlights the power of molecular innovation to transform fertility care and address critical challenges in women's health. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40676]

Join Fadel Zeidan, Ph.D. for a guided meditation. Follow along as he teaches simple breathing techniques and short practices designed to build focus and calm the nervous system. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40783]

Andrea Z. LaCroix, Ph.D. presents major public health trends affecting women across the lifespan, from rising maternal mortality and chronic disease risks linked to pregnancy complications to the ongoing need for improved menopause care. She highlights innovative research, including digital tools for menopause education, studies on cancer survivorship, and efforts to predict healthy aging using epigenetic clocks and physical activity data. LaCroix shows how decades of research continue to shape strategies for aging with preserved cognitive and physical function, aiming to help more women thrive into their 90s and beyond. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40766]

As part of the 2025 Developmental Disabilities Conference, Dr. Diane Cullinane talks about the spectrum of therapeutic approaches for working with people with autism. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 40615]

UCSF's Dr. Cornelia Ding demystifies the prostate cancer pathology report and explains how to read and understand it. The report contains five key sections: patient information, diagnosis and comments, gross description, and any addendums or amendments. It serves multiple purposes—as a medical, legal, and clinical communication tool—and often contains technical language not written for patients. Dr. Ding walks through important terminology such as Gleason score, Grade Groups, and specific diagnostic patterns like intraductal carcinoma, emphasizing how each affects risk assessment and treatment planning. Patients are encouraged to focus on the diagnosis and comment sections and to discuss any unclear details with their doctors. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40797]

Prostate cancer remains the most commonly diagnosed cancer and second leading cause of cancer death among men in the U.S., with evolving screening and treatment practices reshaping care in 2025. UCSF's Dr. Matthew Cooperberg highlights a shift away from overdiagnosis and overtreatment of low-risk cancers, focusing instead on identifying aggressive disease through tools like MRI and advanced biomarker tests. A new “smarter screening” model now guides primary care, recommending long testing intervals for men with low PSA levels. While active surveillance has increased nationally, significant variation in care remains, and racial disparities—especially for Black men—persist. Patients are encouraged to take time in making treatment decisions, as prostate cancer often progresses slowly and allows for thoughtful, personalized care. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40796]

As part of the 2025 Developmental Disabilities Conference, Yao Du from the Keck School of Medicine at USC, talk about the risks and benefits of technology and generative AI. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 40624]

As part of the 2025 Developmental Disabilities Conference, Edlyn Peña, Professor of Educational Leadership Doctoral Program at California Lutheran University, Emma Cladis, a Vanguard University student, talk about college for people with autism. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 40612]

As part of the 2025 Developmental Disabilities Conference, Dr. Eric London talks about understanding autism. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 40618]

As part of the 2025 Developmental Disabilities Conference, Marta E. Wosińska from the Center on Health Policyat The Brookings Institution talks about medication shortages. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 40616]

Dr. Hao Nguyen presents focal therapy as a promising treatment option for carefully selected prostate cancer patients, especially those with intermediate-risk, localized disease. Unlike whole-gland treatments, focal therapy targets only the tumor while preserving healthy tissue, reducing the risk of side effects like urinary or sexual dysfunction. UCSF offers multiple approaches—high-intensity focused ultrasound, cryotherapy, and irreversible electroporation—selected based on tumor location and anatomy. Dr. Nguyen emphasizes the importance of precise imaging, MRI fusion biopsy, and genomic testing for patient selection and treatment planning. Early outcomes show encouraging results, with most patients avoiding surgery or radiation within two years and maintaining quality of life. While not yet standard first-line care, focal therapy is gaining traction through research and expert consensus. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40804]

As part of the 2025 Developmental Disabilities Conference, Dr. Whitney Deal, an emergency physician at MedStar Union Memorial Hospital, talks about using the least restrictive approach when dealing with an agitated autistic patient. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 40614]

UCSF oncologist Dr. Jonathan Chou discusses how genetics and genomics are transforming the diagnosis and treatment of prostate cancer. He explains how inherited and acquired mutations—especially in DNA repair genes like BRCA2—can impact both cancer risk and treatment decisions. Dr. Chou outlines how UCSF researchers use tumor and blood-based biopsies to identify key mutations and genomic features that help tailor care for each patient. Examples include how genomic scores can predict response to radiation and how targeted therapies like PARP inhibitors benefit patients with specific mutations. The talk highlights the growing role of precision medicine in guiding individualized treatment plans based on the unique genetic profile of each patient's cancer. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40798]

In this excerpt, Dr. Natalie Marshall shares tips on starting exercise routines. Dr. Marshall emphasizes how doing something, exercise-wise, is significantly better than doing nothing. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 40687]

UCSF's Dr. Rahul Aggarwal explains the role of clinical trials in advancing prostate cancer treatment and how trial design is evolving to match today's more personalized approaches. He highlights how UCSF has contributed to major prostate cancer therapies and emphasizes the importance of genetic and genomic testing in identifying suitable trials for each patient. Dr. Aggarwal explains the different trial phases, clarifies common myths—such as concerns about placebos—and stresses that trials are considered at every stage of disease. He also discusses efforts to improve access, affordability, and diversity in trial participation, including regional partnerships and digital matching tools. The talk encourages patients to be informed and proactive when considering clinical trials as part of their treatment plan. Series: "Prostate Cancer Patient Conference" [Health and Medicine] [Show ID: 40800]

As part of the 2025 Developmental Disabilities Conference, Anne V. Kirby, Associate Professor, University of Utah, talks about suicide prevention in the autism community. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 40610]

As part of the 2025 Developmental Disabilities Conference, Peggy McManus with The National Alliance to Advance Adolescent Health/Got Transition talks about barriers, inequities and policy options for youth aging out of public programs. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 40609]

In this excerpt, Dr. Natalie Marshall focuses on numerous forms of strength training as it is the best way to increase muscle mass and and it will help you get started “building muscle for life." Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 40686]

Experts discuss recent advances in how maternal health and immune function during pregnancy affect infant development and long-term outcomes. Research focuses on immune adaptations, complications like preterm birth, and neuroimmune pathways, using techniques such as mass cytometry, spatial proteomics, and chemogenetics to identify biomarkers and mechanisms that guide prevention and treatment strategies. Sandy Ramos, M.D. Clinical Landscape and OGRS Opportunities Louise Laurent, M.D.,Ph.D. Single-Cell and Spatial Multi-Omic Insights into the Human Placenta (HUBMAP) Marni Jacobs, Ph.D. The MOM-Health Study and the MOHD Consortium Lars Bode, Ph.D. Human Milk Institute (HMI) Gretchen Bandoli, Ph.D. MotherToBaby Ina Stelzer, Ph.D. Reproductive Immunology Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40666]

Explore key aspects of aging and menopause, focusing on women's health and how biological changes impact overall well-being. Experts discuss current research on healthy aging, including the role of physical activity, brain health, and hormone changes during menopause. They highlight how sex differences affect diseases like Alzheimer's and emphasize the importance of personalized approaches to treatment and prevention. The presentation also underscores ongoing studies and resources aimed at improving the quality of life for aging women through better understanding and support Linda Brubaker, M.D.,M.S. Clinical Landscape and OGRS Opportunities Amanda Lewis, Ph.D. Glycobiology (GLOW) Andrea LaCroix, Ph.D. Healthy Aging After Menopause Anthony Molina, Ph.D. Stein Institute for Research on Aging Sarah Banks, Ph.D. Alzheimer in Women Emily Lukacz, M.D.,M.A.S. Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium and Pelvic Floor Disorders Network (PFDN) Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40668]

Menstruation is the cyclical shedding of the endometrium triggered by falling progesterone levels. Menstruation is a rare trait found in less than 2% of mammals and likely evolved independently at least 4 times. Why do some mammals menstruate while most do not? The leading hypothesis is that menstruation occurs as a nonadaptive consequence of spontaneous decidualization of the endometrium, which evolved to increase biosensoring of embryo quality. While the trait of spontaneous decidualization (and as a byproduct, menstruation) was likely shaped by natural selection, menstruation also disposes women to conditions such as endometriosis, pre-menstrual syndrome, and bleeding disorders, especially in the contemporary context. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Health and Medicine] [Humanities] [Science] [Show ID: 40693]

In this program, Dr. Sean Spencer explores the healthy way in which carbohydrates are digested throughout the body. To understand this concept Dr. Spencer discusses the difference between digesting simple sugars and complex carbohydrates.   Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 40774]

William Lowry, Ph.D., discusses manipulating metabolic pathways in hair follicle stem cells to inhibit tumorigenesis. By blocking glycolysis and glutamine lysis simultaneously, they observed tumor regression, highlighting the complex interplay between metabolism and cancer. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39256]

Experts highlight innovative research and clinical advances in fertility and infertility. Speakers share new ways to improve IVF outcomes using liquid biopsy and RNA analysis, aiming to predict embryo quality without invasive tests. They also explore how imaging technologies can better detect and monitor reproductive cancers, helping tailor treatments for conditions like ovarian and cervical cancer. Throughout, there's a focus on addressing health disparities, improving care for all genders, and using big data and AI to personalize reproductive health solutions. Antoni Duleba, M.D. Clinical Landscape and OGRS Opportunities Rebecca Rakow Penner, M.D.,Ph.D. Imaging in Gynecologic Disorders Jennifer Anger, M.D.,M.P.H. Interstitial Cystitis/Bladder Pain Syndrome in Reproductive Age Women Sheng Zhong, Ph.D. Silverseq and Liquid Biopsy Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40667]

Curious about the secret to staying young? Rob Signer shares insights into how our bodies age, focusing on the role of stem cells and a critical protein called HSF1 that helps them cope with stress. Signer explores the delicate balance of keeping these cells healthy without increasing cancer risk and highlighted some promising progress in enhancing the cells' ability to manage waste. Series: "Excerpts" [Health and Medicine] [Show ID: 40775]

As part of the 2025 Developmental Disabilities Conference, Dr. Adiaha Spinks-Franklin provides a brief overview of fetal alcohol spectrum disorder. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 40608]

In this excerpt, Dr. Natalie Marshall discusses the central importance of exercise to improve chromosomal and telomere health. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 40683]

Fadel Zeidan, Ph.D., discusses the science of mindfulness and how meditation can change the brain. He explains what happens in the brain during stress, how mindfulness helps us become more self-aware, and why it's important to pay attention on purpose. Zeidan shares easy ways to bring mindfulness into daily life, even in small moments. The video includes guided meditations led by Zeidan. Viewers can follow along as he teaches simple breathing techniques and short practices designed to build focus and calm the nervous system. Whether you're new to meditation or looking to deepen your practice, this program offers useful tools backed by science. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 40267]

As part of the 2025 Developmental Disabilities Conference, Sneha Dave talks about future healthcare as young adults with chronic and rare medical conditions grow older. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 40606]

As part of the 2025 Developmental Disabilities Conference, Season Goodpasture, Founder and Executive Director, Acorns to Oak Trees, talks about improving access and equity in tribal communities. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 40607]

Dr. Terence Friedlander reviews the various patient outcomes after hip fracture surgery. Series: "Excerpts" [Health and Medicine] [Show ID: 40752]

The risk for many chronic diseases is directly linked to metabolic changes in the body and loss of muscle mass often associated with aging. In this excerpt, Dr. Natalie Marshall focuses on the role that muscles play in the body. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 40685]

As part of the 2025 Developmental Disabilities Conference, Amy Westling and Melissa Drake discuss the plan for developmental services from CalHHS and DDS. Series: "Developmental Disabilities Update" [Health and Medicine] [Show ID: 40605]

Dr. Terence Friedlander discusses common issues brought on by osteoporosis. Series: "Excerpts" [Health and Medicine] [Show ID: 40751]

Dr. Sean Spencer talks about the vast microbial world that lives within our guts — known as the gut microbiome — and how it supports our health. Dr. Spencer emphasizes the importance of a high-fiber diet in creating a healthy gut microbiome which increases overall health. Series: "Osher WISE: Well-being and Integrative Science for Everyone" [Health and Medicine] [Show ID: 40761]