Podcasts about uc san diego

Neal sits down with Adam Jacobs, President of Xzōm, a San Diego company developing a near-patient platform for isolating and analyzing exosomes from a small blood sample in under 30 minutes.Exosomes are tiny particles released by living cells that carry proteins and genetic material. Researchers believe these particles could provide useful signals about disease earlier or more dynamically than some existing biomarkers. Xzōm is working to turn that science into a compact testing platform, using a disposable cartridge and a mobile-device interface.The company's initial focus is early pancreatic-cancer detection. Adam also discusses how the underlying platform could potentially be adapted for other areas - including sepsis, preeclampsia, transplant monitoring, and neurological conditions - by changing the biomarkers targeted by each assay. Those applications would require their own development, clinical validation, and regulatory pathways.Adam shares his unusual route to biotech: Torrey Pines High School, Cornell baseball, professional ball in Australia, a clothing brand, a yoga studio, and a consulting firm. He also explains how technology originating at UC San Diego eventually came back into his life, Xzōm's partnership-led development model, and the role data analysis may play in interpreting complex biological signals.Plus, Adam and Neal bond over a shared appreciation for Roberto's on Carmel Valley Road.Key topics* Isolating and analyzing exosomes on one chip in 30 minutes* Why exosomes catch disease earlier than DNA - “stage zero”* A point-of-care lab that runs on a cell phone* The difference between a versatile platform and a validated diagnostic test* From pancreatic cancer to sepsis, preeclampsia, and brain injury* How Xzōm works with clinical and commercial partners* Adam's path from pro baseball to biotech* Why AI on the back end makes the whole thing work* Giving back: showing up, not just writing checksLinks & resources* Xzōm* A Morning Inside Xzōm's Lab Connect on LinkedIn* Neal Bloom * Adam Jacobs This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit risingtidepartners.substack.com/subscribe

Do you use your imagination enough? Most parents think of imagination as something for playtime — a "nice to have" that fades once kids get older and life gets "serious." But Dr. Cassandra Vieten, director of science programs at the Arthur C. Clarke Center for Human Imagination at UC San Diego, joins Dr. Aliza Pressman to make the case that imagination is a trainable skill with real developmental and psychological weight. They unpack the connection between imagination and anxiety, why kids naturally live closer to the "field of possibility" than adults do, and how something as simple as a car-ride question can open up conversations that "how was your day?" never will. What You'll Learn: The real, physiological link between imagination and anxiety How to use your child's favorite fandom as a doorway into connection Strategies to turn discipline moments into imagination-building thought experiments How to use screens and social media for connection instead of "slot machine" scrolling

E-bike crashes and injuries in California are increasing, a new study out of UC San Diego finds. And those injuries are not only more severe compared with conventional bikes, they'redisproportionately involving kids age 14 and younger. We'll hear how doctors, lawmakers andbiking advocates are responding to the risks posed by e-bikes – and by what some call emotorcycles – and we'll hear your takes about how we can make our roads safer for all. Guests: Azul Dahlstrom-Eckman, reporter, KQED Asha Weinstein Agrawal, professor and researcher, Mineta Transportation Institute at San Jose State University John Maa, governor and former president, American College of Surgeons; former trauma surgeon, MarinHealth Medical Center; co-author of the new study from UCSD, “An exponential increase in e-bike injuries in California” Learn more about your ad choices. Visit megaphone.fm/adchoices

Message Dan and MikeWe're back from our first San Diego Comic-Con with press credentials, and this episode kicks off a two-part recap of the entire experience. Part one covers our arrival, the scramble to find the convention center on San Diego's trolley system, and the reality check that comes with picking up press badges for the first time. We also take a detour to Seaport Village for tacos and a beer with a view of the harbor, then head north to UC San Diego for a surprise highlight of the trip: Shredding the Multiverse, a concert reimagining television and film scores from shows like Cobra Kai, Spider-Man, and The Penguin with a full orchestra and rock energy.From there we walk through preview night, our first real taste of the exhibit hall, complete with two-hour lines, an ocean of vendors, and a candid discussion about what press credentials do and don't actually get you at a con this size. We get into a few Comic-Con-brain moments (yes, we coin the term), some sibling bickering about San Diego weather, and a genuinely strange arcade cabinet encounter that turns into its own little subplot.The back half of the episode dives into two of our favorite panels from day one. First, a look at the upcoming Lucas Museum of Narrative Art, opening in Los Angeles this September, and why it's a celebration of storytelling and visual art far beyond just Star Wars. Then we sit in on Brad Bird's career retrospective panel, tracing his path from The Iron Giant and The Incredibles to Mission: Impossible – Ghost Protocol and his surprising, nearly two-hundred-episode history with The Simpsons. Bird also previews his new animated sci-fi noir series Ray Gun and drops a small but exciting update on the status of Incredibles 3.It's an exhausting, funny, occasionally chaotic first day, and we haven't even gotten to Hall H yet. That's coming in part two, along with days two and three of the convention. Thanks for riding along with us on our first Comic-Con as press, sore feet and all.Support the showOh Brother Podcast:Support the Show! (Be The First to Listen with Early Access)Listen on all podcast platformsSubscribe on YouTubeFollow us on Instagram

Editor's Choice:  Biomarker heterogeneity and efficacy of durvalumab plus carboplatin/paclitaxel followed by durvalumab with or without olaparib in patients with mismatch repair proficient endometrial cancer: exploratory analyses of the DUO-E/GOG-3041/ENGOT-EN10 trialEditorial: Hitting the mark—or missing it? The promise and peril of biomarkers in endometrial cancerHosted by: Amanda Nickles Fader, MD; Johns Hopkins Medicine Baltimore, MD, USAFeaturing: Kathleen Moore, MD; Gynecologic Cancer Clinic, Stephenson Cancer Center at the University of Oklahoma Medical Center, Oklahoma City, OK, USARamez N Eskander, MD;  Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Gynecologic Oncology, UC San Diego, USACheck out more content on the journal's homepage  at https://www.gynecologiconcology-online.net

Chronic pain in older adults can affect mobility, mood, sleep, social connection, and independence. Una Makris, M.D., M.Sc., UC San Diego and VA San Diego Healthcare System, explains why musculoskeletal pain is common later in life and why medications or procedures alone may not meet the needs of many patients. Drawing on her work in rheumatology and geriatrics, Makris describes how pain and depression can reinforce each other, making it important to address both together. She highlights an age-friendly behavioral coaching approach that uses motivational interviewing, values-based goal setting, physical activity, and social support to help people reconnect with meaningful activities. By focusing on small, safe increases in movement, this research points to practical ways to support better function, quality of life, and healthy aging. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41172]

Chronic pain in older adults can affect mobility, mood, sleep, social connection, and independence. Una Makris, M.D., M.Sc., UC San Diego and VA San Diego Healthcare System, explains why musculoskeletal pain is common later in life and why medications or procedures alone may not meet the needs of many patients. Drawing on her work in rheumatology and geriatrics, Makris describes how pain and depression can reinforce each other, making it important to address both together. She highlights an age-friendly behavioral coaching approach that uses motivational interviewing, values-based goal setting, physical activity, and social support to help people reconnect with meaningful activities. By focusing on small, safe increases in movement, this research points to practical ways to support better function, quality of life, and healthy aging. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41172]

Chronic pain in older adults can affect mobility, mood, sleep, social connection, and independence. Una Makris, M.D., M.Sc., UC San Diego and VA San Diego Healthcare System, explains why musculoskeletal pain is common later in life and why medications or procedures alone may not meet the needs of many patients. Drawing on her work in rheumatology and geriatrics, Makris describes how pain and depression can reinforce each other, making it important to address both together. She highlights an age-friendly behavioral coaching approach that uses motivational interviewing, values-based goal setting, physical activity, and social support to help people reconnect with meaningful activities. By focusing on small, safe increases in movement, this research points to practical ways to support better function, quality of life, and healthy aging. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41172]

Chronic pain in older adults can affect mobility, mood, sleep, social connection, and independence. Una Makris, M.D., M.Sc., UC San Diego and VA San Diego Healthcare System, explains why musculoskeletal pain is common later in life and why medications or procedures alone may not meet the needs of many patients. Drawing on her work in rheumatology and geriatrics, Makris describes how pain and depression can reinforce each other, making it important to address both together. She highlights an age-friendly behavioral coaching approach that uses motivational interviewing, values-based goal setting, physical activity, and social support to help people reconnect with meaningful activities. By focusing on small, safe increases in movement, this research points to practical ways to support better function, quality of life, and healthy aging. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41172]

Chronic pain in older adults can affect mobility, mood, sleep, social connection, and independence. Una Makris, M.D., M.Sc., UC San Diego and VA San Diego Healthcare System, explains why musculoskeletal pain is common later in life and why medications or procedures alone may not meet the needs of many patients. Drawing on her work in rheumatology and geriatrics, Makris describes how pain and depression can reinforce each other, making it important to address both together. She highlights an age-friendly behavioral coaching approach that uses motivational interviewing, values-based goal setting, physical activity, and social support to help people reconnect with meaningful activities. By focusing on small, safe increases in movement, this research points to practical ways to support better function, quality of life, and healthy aging. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41172]

Chronic pain in older adults can affect mobility, mood, sleep, social connection, and independence. Una Makris, M.D., M.Sc., UC San Diego and VA San Diego Healthcare System, explains why musculoskeletal pain is common later in life and why medications or procedures alone may not meet the needs of many patients. Drawing on her work in rheumatology and geriatrics, Makris describes how pain and depression can reinforce each other, making it important to address both together. She highlights an age-friendly behavioral coaching approach that uses motivational interviewing, values-based goal setting, physical activity, and social support to help people reconnect with meaningful activities. By focusing on small, safe increases in movement, this research points to practical ways to support better function, quality of life, and healthy aging. Series: "Stein Institute for Research on Aging" [Health and Medicine] [Show ID: 41172]

Authentic autism representation begins with listening to autistic people and including them in stories about their lives. Seth Bakke, producer, writer and director of The Rescue, explains how his autistic cousin Aaron and a poem by autistic typer Peter Tran inspired the film. Bakke describes working with Aaron on screen, consulting the Tran family and adapting the set to support his needs. Autistic typers Otto Lana and Peter Tran, joined by Steven Tran, a postdoctoral researcher at UC San Diego, discuss where the film reflects their experiences, where it simplifies communication through typing and why creative freedom must remain grounded in lived experience. They address presuming competence, the difference between hearing and listening, and the need for autistic actors and advisers. Their participation challenges stereotypes and helps audiences see they should be full participants in their own stories. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Arts and Music] [Show ID: 41175]

Authentic autism representation begins with listening to autistic people and including them in stories about their lives. Seth Bakke, producer, writer and director of The Rescue, explains how his autistic cousin Aaron and a poem by autistic typer Peter Tran inspired the film. Bakke describes working with Aaron on screen, consulting the Tran family and adapting the set to support his needs. Autistic typers Otto Lana and Peter Tran, joined by Steven Tran, a postdoctoral researcher at UC San Diego, discuss where the film reflects their experiences, where it simplifies communication through typing and why creative freedom must remain grounded in lived experience. They address presuming competence, the difference between hearing and listening, and the need for autistic actors and advisers. Their participation challenges stereotypes and helps audiences see they should be full participants in their own stories. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Arts and Music] [Show ID: 41175]

Authentic autism representation begins with listening to autistic people and including them in stories about their lives. Seth Bakke, producer, writer and director of The Rescue, explains how his autistic cousin Aaron and a poem by autistic typer Peter Tran inspired the film. Bakke describes working with Aaron on screen, consulting the Tran family and adapting the set to support his needs. Autistic typers Otto Lana and Peter Tran, joined by Steven Tran, a postdoctoral researcher at UC San Diego, discuss where the film reflects their experiences, where it simplifies communication through typing and why creative freedom must remain grounded in lived experience. They address presuming competence, the difference between hearing and listening, and the need for autistic actors and advisers. Their participation challenges stereotypes and helps audiences see they should be full participants in their own stories. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Arts and Music] [Show ID: 41175]

Authentic autism representation begins with listening to autistic people and including them in stories about their lives. Seth Bakke, producer, writer and director of The Rescue, explains how his autistic cousin Aaron and a poem by autistic typer Peter Tran inspired the film. Bakke describes working with Aaron on screen, consulting the Tran family and adapting the set to support his needs. Autistic typers Otto Lana and Peter Tran, joined by Steven Tran, a postdoctoral researcher at UC San Diego, discuss where the film reflects their experiences, where it simplifies communication through typing and why creative freedom must remain grounded in lived experience. They address presuming competence, the difference between hearing and listening, and the need for autistic actors and advisers. Their participation challenges stereotypes and helps audiences see they should be full participants in their own stories. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Arts and Music] [Show ID: 41175]

Authentic autism representation begins with listening to autistic people and including them in stories about their lives. Seth Bakke, producer, writer and director of The Rescue, explains how his autistic cousin Aaron and a poem by autistic typer Peter Tran inspired the film. Bakke describes working with Aaron on screen, consulting the Tran family and adapting the set to support his needs. Autistic typers Otto Lana and Peter Tran, joined by Steven Tran, a postdoctoral researcher at UC San Diego, discuss where the film reflects their experiences, where it simplifies communication through typing and why creative freedom must remain grounded in lived experience. They address presuming competence, the difference between hearing and listening, and the need for autistic actors and advisers. Their participation challenges stereotypes and helps audiences see they should be full participants in their own stories. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Arts and Music] [Show ID: 41175]

Authentic autism representation begins with listening to autistic people and including them in stories about their lives. Seth Bakke, producer, writer and director of The Rescue, explains how his autistic cousin Aaron and a poem by autistic typer Peter Tran inspired the film. Bakke describes working with Aaron on screen, consulting the Tran family and adapting the set to support his needs. Autistic typers Otto Lana and Peter Tran, joined by Steven Tran, a postdoctoral researcher at UC San Diego, discuss where the film reflects their experiences, where it simplifies communication through typing and why creative freedom must remain grounded in lived experience. They address presuming competence, the difference between hearing and listening, and the need for autistic actors and advisers. Their participation challenges stereotypes and helps audiences see they should be full participants in their own stories. Series: "Autism Tree Project Annual Neuroscience Conference" [Health and Medicine] [Science] [Arts and Music] [Show ID: 41175]

Scientific progress depends on curiosity, investment and the freedom to take risks. Nobel Laureate and UC San Diego alumnus Fred Ramsdell traces his path from community college to biotechnology and a discovery that reshaped understanding of immune regulation. He explains how decades of publicly funded research made that breakthrough possible and why failed experiments are essential steps toward discovery. Ramsdell discusses threats to federal research funding, the private sector's limited tolerance for risk and the need for scientists to communicate clearly. Rebuilding trust, he argues, starts with listening, finding shared values and explaining how basic research leads to new treatments, economic value and national security. Sustained support for science matters because no one can predict where the next major breakthrough will begin. Series: "Deep Look Public Speaker Series" [Science] [Show ID: 41113]

Scientific progress depends on curiosity, investment and the freedom to take risks. Nobel Laureate and UC San Diego alumnus Fred Ramsdell traces his path from community college to biotechnology and a discovery that reshaped understanding of immune regulation. He explains how decades of publicly funded research made that breakthrough possible and why failed experiments are essential steps toward discovery. Ramsdell discusses threats to federal research funding, the private sector's limited tolerance for risk and the need for scientists to communicate clearly. Rebuilding trust, he argues, starts with listening, finding shared values and explaining how basic research leads to new treatments, economic value and national security. Sustained support for science matters because no one can predict where the next major breakthrough will begin. Series: "Deep Look Public Speaker Series" [Science] [Show ID: 41113]

Scientific progress depends on curiosity, investment and the freedom to take risks. Nobel Laureate and UC San Diego alumnus Fred Ramsdell traces his path from community college to biotechnology and a discovery that reshaped understanding of immune regulation. He explains how decades of publicly funded research made that breakthrough possible and why failed experiments are essential steps toward discovery. Ramsdell discusses threats to federal research funding, the private sector's limited tolerance for risk and the need for scientists to communicate clearly. Rebuilding trust, he argues, starts with listening, finding shared values and explaining how basic research leads to new treatments, economic value and national security. Sustained support for science matters because no one can predict where the next major breakthrough will begin. Series: "Deep Look Public Speaker Series" [Science] [Show ID: 41113]

Scientific progress depends on curiosity, investment and the freedom to take risks. Nobel Laureate and UC San Diego alumnus Fred Ramsdell traces his path from community college to biotechnology and a discovery that reshaped understanding of immune regulation. He explains how decades of publicly funded research made that breakthrough possible and why failed experiments are essential steps toward discovery. Ramsdell discusses threats to federal research funding, the private sector's limited tolerance for risk and the need for scientists to communicate clearly. Rebuilding trust, he argues, starts with listening, finding shared values and explaining how basic research leads to new treatments, economic value and national security. Sustained support for science matters because no one can predict where the next major breakthrough will begin. Series: "Deep Look Public Speaker Series" [Science] [Show ID: 41113]

Hear from two experts in osteoporosis as they introduce the Osteoporosis Action Network—a volunteer coalition of osteoporosis leaders and industry partners focused on redefining the standard of care in osteoporosis, with a bold ambition of preventing 3 million fractures by 2033. Rita Roy, MD, CEO, National Spine Health Foundation will discuss the coalition's mission and vision, while Susan Bukata, MD, Professor and Chair, Department of Orthopaedics, UC San Diego, will discuss the motivation behind the creation of the coalition and share her experience with post-fracture care programs. Listeners will gain insights into action they can take to get post-fracture care programs off the ground and close care gaps. Dr. Roy and Dr. Bukata are paid consultants for Amgen. Initial support for Osteoporosis Action Network provided by Amgen.This episode is sponsored by Amgen.

First, the DOJ has accused UC San Diego of racial discrimination. Then, we'll tell you why a billion dollars in medicaid reimbursements is being withheld. Also, a request to raise SDG&E rates is being opposed by some. And, we'll tell you how you can be involved with Comic-Con without having a badge.

Imagine an Immigration and Customs Enforcement (ICE) facility. Is "detention center" the accurate way to describe it?Political scientists and legal scholars have been asking whether we're using the right language to talk about immigration enforcement. Some argue that calling them "immigrant jails," "immigration camps," or even "concentration camps" is more accurate.But others say using the term "concentration camp" diminishes the horrors of the Holocaust — the Nazi genocide of Jewish people.The debate around the language we use to describe immigration is not new. Experts have also considered how to describe the incarceration of Japanese Americans on U.S. soil during World War II.On KPBS Midday Edition, we sit down with three experts to help us unpack this debate and help us understand the weight of our language.Guests:Tom Wong, associate professor of political science, UC San Diego; director of U.S. Immigration Policy CenterRaquel Aldana, professor of law, UC DavisBenjamin Gonzalez O'Brien, professor of political science, San Diego State University; editor of Journal of Race, Ethnicity and PoliticsKeep reading:When do ‘detention centers' become ‘concentration camps'? Experts look to historyWhen immigration detention becomes a system of concentration: Lessons from research on 150 historical casesThis Isn't The 1st Time Americans Have Debated What To Call Detention CentersConcentration Camps Are Older Than World War IIOne Long Night: A Global History of Concentration CampsAmid escalating medical concerns, Otay Mesa Detention Center faces a question of oversight

An outbreak of a severe stomach illness leading to diarrhea, fatigue, and stomach pain has hit several states in the past few months, concerning public health officials across the country.Case numbers of cyclosporiasis in San Diego County remain low, with no local outbreaks detected as of yet.On Midday Edition Monday, we talk about the illness — its symptoms, treatment options, and what you can do to prevent its spread.Guests:Dr. Ankita Kadakia, deputy public health officer, County of San DiegoRichard Garfein, PhD, Professor, Herbert Wertheim School of Public Health, UC San Diego

En menos de una semana, dos personas murieron por disparos de agentes del Servicio de Inmigración y Control de Aduanas de Estados Unidos. ICE está ejecutando una campaña de detenciones a una escala extraordinaria. Se han contabilizado al menos siete personas muertas por disparos durante acciones migratorias desde el regreso de Donald Trump a la Casa Blanca en enero de 2025. ¿Qué ha cambiado dentro de ICE en este segundo mandato de Trump? Rafael Fernández de Castro, Director del Centro de Estudios México-Estados Unidos de UC San Diego, nos habla al respecto. En otro tema: Ya terminó la Copa del Mundo. Un mes que fue maravilloso para muchos, excelente para España.

In this episode we speak with Alon Goren from UC San Diego about his work at the intersection of genomic technology development and chromatin biology. We discuss how his lab studies how the epigenome is regulated, how disruption of that regulation contributes to disease, and how technology can be improved to make results more robust and reproducible. We talk about his early interest in biology, how that developed through medical research training, and how a molecular biology lab shaped the direction of his career. He explains how curiosity about how cells and organisms work led him toward genomics and chromatin research. We then discuss several methods from his career, including early direct sequencing approaches for small amounts of DNA and RNA, ChIP-based methods for chromatin regulators, and work on improving ChIP-seq workflows. He explains why antibody choice matters, why monoclonal antibodies can improve reproducibility, and how automation helped scale the process. We also cover his work on spike-in normalization, including the risks of using exogenous chromatin incorrectly and the need for better safeguards in genome-wide comparisons. He describes a newer approach that uses two spike-ins to provide multiple checks on normalization. Finally, we discuss his work on short tandem repeats, zebrafish heart regeneration, and SIRT6-related polymerase pausing, as well as a newer platform that converts molecular interactions into sequencing-readable barcodes. He closes by stressing the importance of validation, careful protocol design, and methods that can be used reliably by multiple people. References Ram, O., Goren, A., Amit, I., Shoresh, N., Yosef, N., Ernst, J., Kellis, M., Gymrek, M., Issner, R., Coyne, M., Durham, T., Zhang, X., Donaghey, J., Epstein, C. B., Regev, A., & Bernstein, B. E. (2011). Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells. Cell, 147(7), 1628–1639. https://doi.org/10.1016/j.cell.2011.09.057 Busby, M., Xue, C., Li, C., Farjoun, Y., Gienger, E., Yofe, I., Gladden, A., Epstein, C. B., Cornett, E. M., Rothbart, S. B., Nusbaum, C., & Goren, A. (2016). Systematic comparison of monoclonal versus polyclonal antibodies for mapping histone modifications by ChIP-seq. Epigenetics & chromatin, 9, 49. https://doi.org/10.1186/s13072-016-0100-6 Patel, L. A., Cao, Y., Mendenhall, E. M., Benner, C., & Goren, A. (2024). The Wild West of spike-in normalization. Nature biotechnology, 42(9), 1343–1349. https://doi.org/10.1038/s41587-024-02377-y Ben-Yair, R., Butty, V. L., Busby, M., Qiu, Y., Levine, S. S., Goren, A., Boyer, L. A., Burns, C. G., & Burns, C. E. (2019). H3K27me3-mediated silencing of structural genes is required for zebrafish heart regeneration. Development (Cambridge, England), 146(19), dev178632. https://doi.org/10.1242/dev.178632 Patel, L., Cao, Y., Xu, T., Modolo, E., Dishon, T., Zhang, L., Mendenhall, E., Heinz, S., Simon, I., Benner, C., & Goren, A. (2025). Improved spike-in normalization clarifies the relationship between active histone modifications and transcription. Genomics. https://doi.org/10.1101/2025.11.25.690627 Xu, T., Wang, J., Shin, Y., Cao, Y., Zhang, L., Modolo, E., Dishon, T., Fisher, J., Norton, M., Fry, C. J., Farjoun, Y., Mendenhall, E., Heinz, S., Benner, C., & Goren, A. (2026). Multiplexed measurements of protein-protein interactions and protein abundance across cellular conditions using Prod&PQ-seq. Genomics. https://doi.org/10.64898/2026.01.01.697286 Related Episodes Taking ChIP from Yeast to ENCODE to Enable Genome-Wide Regulatory Protein Mapping (Peggy Farnham) Comparing CUT&Tag to ENCODE ChIP-Seq in Alzheimer's Disease Samples (Sarah Marzi) Chromatin Profiling: From ChIP to CUT&RUN, CUT&Tag and CUTAC (Steven Henikoff) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

A completed, unpublished Dr. Seuss manuscript was recently discovered in author Theodor Geisel's archives at UC San Diego. How was the book found, and what does it reveal about the author's creative process and complicated legacy? USA TODAY Books Reporter Clare Mulroy joins The Excerpt to share her reporting.Plus, watch "Sing the 50 United States" written by Dr. Seuss.Let us know what you think of this episode by sending an email to podcasts@usatoday.com. Episode transcript available here. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Seven years ago, the University of California assembled a committee to study whether standardized tests actually predict anything. The committee said keep them. So, in typical California fashion, they ignored their own committee and went test blind. Here's how that worked out. At UC San Diego, nearly 12% of last fall's freshmen weren't qualified to take pre-calculus. In 2020 that number was 0.5%. A Berkeley English professor put it this way: "After the SAT was dropped, I got students who could not write a sentence." More than 1,500 science and math professors — including the chairs of 60-plus departments — signed a letter asking the university to bring the test back. Another 700 humanities professors signed one of their own. Hundreds of faculty called it an emergency. The New York Times just ran a very long editorial about all of it. Which, coming from the New York Times, is a little surprising. Round up the usual suspects. Shocked — shocked! — to find that grade inflation has been going on in here. MIT, every Ivy, the entire University of Florida and Georgia systems have already abandoned test optional, for the boring reason that the SAT and ACT predict how a kid will actually do better than a GPA does. And GPAs have been inflated egregiously for the last 15, 20 years. A high school a couple towns from our office just named 21 valedictorians out of 300-some kids. Every news story said the same thing: wow, they're so smart. They are smart. They're not all valedictorian. So here's the advice, and it's the same advice regardless of whether your kid is a great test taker or a terrible one: do not PLAN on applying test optional. That is not the same as saying don't apply test optional — there's a difference between applying test optional and getting in test optional. Start prep early. Take a diagnostic first so you're not spinning your wheels on the wrong test. Then plan on sitting for it about three times; past three or four you hit diminishing returns. Whether you submit the score is a case-by-case decision. Whether you prepare is not. Then Pearl takes the second half: what actually changed on July 1st under the One Big Beautiful Bill Act. Grad PLUS loans are gone. Parents are now capped at $65,000 total per kid — $20,000 in any one year — with no income-driven repayment to fall back on. And one restriction in the bill just got struck down in court, which is good news if you're chasing public service loan forgiveness. In this episode:- The NYT editorial and the UC San Diego numbers behind it- Why MIT, the Ivies, Florida and Georgia all reversed course- 21 valedictorians, 300 kids, and what grade inflation did to the transcript- Applying test optional vs. getting in test optional- How many times your kid should actually sit for the test- Grad PLUS is gone: the new $100K and $200K lifetime caps- The $65,000 parent borrowing cap — and who got grandfathered in- Public service loan forgiveness: the restriction that got struck down- Why Washington tightened it all: the government was losing 25 cents on every dollar it lent Pearl's loan work lives at yesterdaysdebt.com — she'll pull apart what you actually owe and what your real options are. If she can't find you savings, you don't pay. More at LockwoodCollegePrep.com — the stuff you're not going to get from your guidance counselor. Promise. College Coffee Talk goes live every Monday at 10am ET on Facebook.

In this episode of PeDRA Pearls, Heather Gochnauer, MD, joins the podcast to talk about her path into pediatric dermatology, her work at Rady Children's and UC San Diego, and the clinical and research questions that motivate her early career. This conversation explores continuity of care from childhood into adulthood, Heather's growing focus on connective tissue disease, and the role of collaboration, mentorship, and curiosity in shaping meaningful research for patients and families.This episode is presented by Disc Medicine. Although Disc Medicine provided funding for this PeDRA Pearls Podcast, the contents of the podcast were developed independently by PeDRA. Learn more about Disc Medicine

Art can connect personal history, community, and social change. Janelle Iglesias, Assistant Professor of Studio Art at UC San Diego, traces her path from a multicultural childhood in Queens to anthropology, ceramics, sculpture, and public art. She explains how objects in her family home sparked an interest in material culture, and how a reconciliation program in South Africa changed her view of what artists can contribute to society. Iglesias also describes nearly two decades of collaboration with her sister Lisa through Las Hermanas Iglesias, including projects involving their mother. Her teaching emphasizes play, curiosity, resourcefulness, and the idea that sculpture can be made from almost anything. By linking creative practice with care, connection, and community, Iglesias shows how art can help people respond to uncertainty and imagine more equitable futures. Series: "Mi Universidad " [Arts and Music] [Education] [Show ID: 41254]

Art can connect personal history, community, and social change. Janelle Iglesias, Assistant Professor of Studio Art at UC San Diego, traces her path from a multicultural childhood in Queens to anthropology, ceramics, sculpture, and public art. She explains how objects in her family home sparked an interest in material culture, and how a reconciliation program in South Africa changed her view of what artists can contribute to society. Iglesias also describes nearly two decades of collaboration with her sister Lisa through Las Hermanas Iglesias, including projects involving their mother. Her teaching emphasizes play, curiosity, resourcefulness, and the idea that sculpture can be made from almost anything. By linking creative practice with care, connection, and community, Iglesias shows how art can help people respond to uncertainty and imagine more equitable futures. Series: "Education Channel" [Arts and Music] [Education] [Show ID: 41254]

Art can connect personal history, community, and social change. Janelle Iglesias, Assistant Professor of Studio Art at UC San Diego, traces her path from a multicultural childhood in Queens to anthropology, ceramics, sculpture, and public art. She explains how objects in her family home sparked an interest in material culture, and how a reconciliation program in South Africa changed her view of what artists can contribute to society. Iglesias also describes nearly two decades of collaboration with her sister Lisa through Las Hermanas Iglesias, including projects involving their mother. Her teaching emphasizes play, curiosity, resourcefulness, and the idea that sculpture can be made from almost anything. By linking creative practice with care, connection, and community, Iglesias shows how art can help people respond to uncertainty and imagine more equitable futures. Series: "Mi Universidad " [Arts and Music] [Education] [Show ID: 41254]

Art can connect personal history, community, and social change. Janelle Iglesias, Assistant Professor of Studio Art at UC San Diego, traces her path from a multicultural childhood in Queens to anthropology, ceramics, sculpture, and public art. She explains how objects in her family home sparked an interest in material culture, and how a reconciliation program in South Africa changed her view of what artists can contribute to society. Iglesias also describes nearly two decades of collaboration with her sister Lisa through Las Hermanas Iglesias, including projects involving their mother. Her teaching emphasizes play, curiosity, resourcefulness, and the idea that sculpture can be made from almost anything. By linking creative practice with care, connection, and community, Iglesias shows how art can help people respond to uncertainty and imagine more equitable futures. Series: "Education Channel" [Arts and Music] [Education] [Show ID: 41254]

From co-managing the Odwalla IPO at Van Kasper & Company to raising $100 million with Lehman Brothers for a Pacific Northwest workers comp captive when insurance was unavailable at any price, David Horwich shares why thinking like a buyer, understanding the three ways to grow a business, and building optionality matter more than chasing any specific exit. In this episode of the DealQuest Podcast, host Corey Kupfer sits down with David Horwich, the founder of Horwich Strategic Advisors (HSA) in Los Angeles. David spent 13 years at Van Kasper & Company before its 1999 sale, retired from banking in 2010, and spent nearly nine years at GHJ before spinning out his own firm about a year ago. Across his four decade career he has been exposed to somewhere between 5,000 and 5,500 companies. WHAT YOU'LL LEARN: Why running a market check with five investment banking firms and five private equity groups produces a real world valuation, how the three ways to grow apply to almost any company, and why selling new stuff to existing customers is by far the easiest path. David also shares how the workers comp captive he raised $100 million for is still operating today. DAVID'S JOURNEY: After economics at UC San Diego and an MBA at Berkeley, David spent five years at a transportation equipment leasing business in San Francisco. He then joined Bruce Emeluth as the first hire at Van Kasper & Company, where he stayed 13 years and chaired the firm's fairness opinion committee. Van Kasper was sold in 1999 to a bank out of Salt Lake City that Wells Fargo later acquired, making the group the first incarnation of Wells Fargo Securities in the fall of 2000. David left in 2003, retired from banking in 2010, spent nearly nine years at GHJ, and spun out Horwich Strategic Advisors about a year ago. KEY INSIGHTS: Not all revenue is created equal. Repeatable revenue beats one-off revenue. Higher margin beats lower margin. Revenue that requires no working capital beats revenue that ties it up. Most owners street fight for the next million dollars of revenue without asking whether it is good revenue or bad. There are three ways to grow a business and the second is easiest by far. Sell what you have to more customers. Sell new stuff to existing customers. Sell new stuff to new customers. David is emphatic that you should almost never attempt the third. Existing customers have already crossed the Rubicon with you, so every cost is lower. Build optionality before you build an exit plan. Before running any analysis for owners unsure what to do, David sends them to their investment advisor to get their financial goals clear first. Then he outlines every alternative. Keep it. Sell it. Recapitalize it. Gift some but not all. The toolkit is small, but choosing well requires clarity first. Perfect for privately held business owners who want to know what their company is actually worth, entrepreneurs weighing whether to buy or build, and leaders in a transition moment who need optionality before an exit. FOR MORE ON THIS EPISODE: https://www.coreykupfer.com/blog/davidhorwich FOR MORE ON DAVID HORWICH: Website: https://horwichadvisors.com LinkedIn: https://www.linkedin.com/in/david-horwich-9317b56/ FOR MORE ON COREY KUPFER https://www.linkedin.com/in/coreykupfer/ https://www.coreykupfer.com/ Corey Kupfer is an expert strategist, negotiator, and dealmaker. He has more than 35 years of professional deal-making and negotiating experience. Corey is a successful entrepreneur, attorney, consultant, author, and professional speaker. He is deeply passionate about deal-driven growth. He is also the creator and host of the DealQuest Podcast. Get deal-ready with the DealQuest Podcast with Corey Kupfer, where like-minded entrepreneurs and business leaders converge, share insights and challenges, and success stories. Equip yourself with the tools, resources, and support necessary to navigate the complex yet rewarding world of dealmaking. Dive into the world of deal-driven growth today! Episode Highlights with Timestamps [00:00:00] - Introduction and overview [00:02:42] - Chairman's bag carrier and the waste coal project in Hardin, Montana[00:06:22] - Joining Bruce Emeluth as first hire at Van Kasper & Company [00:11:52] - The Odwalla IPO at $8 a share and the E. coli tragedy [00:24:11] - Exposure to somewhere between 5,000 and 5,500 companies [00:35:26] - The market check and the four questions [00:48:00] - The $100 million workers comp captive with Lehman Brothers[00:50:41] - What freedom means to David Guest Bio David Horwich is the founder of Horwich Strategic Advisors (HSA), a Los Angeles based firm focused on maximizing the value of privately held businesses. He runs market checks that produce real world valuations, builds strategic growth plans, and helps owners think like buyers before any transaction. He has been exposed to somewhere between 5,000 and 5,500 companies across his four decade career. After economics at UC San Diego and an MBA at Berkeley, David spent five years at a transportation equipment leasing business in San Francisco before joining Bruce Emeluth as the first hire at Van Kasper & Company, where he stayed 13 years. Van Kasper was sold in 1999 and became the first incarnation of Wells Fargo Securities in the fall of 2000. David retired from banking in 2010, spent nearly nine years at GHJ, and spun out his own practice about a year ago. Host Bio Corey Kupfer is an expert strategist, negotiator, and dealmaker with more than 35 years of professional deal-making and negotiating experience. Corey is a successful entrepreneur, attorney, consultant, author, and professional speaker deeply passionate about deal-driven growth. He is the creator and host of the DealQuest Podcast. Show Description Do you want your business to grow faster? The DealQuest Podcast with Corey Kupfer reveals how successful entrepreneurs and business leaders use strategic deals to accelerate growth. From large mergers and acquisitions to capital raising, joint ventures, strategic alliances, real estate deals, and more, this show discusses the full spectrum of deal-driven growth strategies. Get the confidence to pursue deals that will help your company scale faster. Related Episodes Episode 330 - Pete Mohr: Building an exit-ready business and understanding what your company is actually worth Episode 332 - John Martinka: Exit with style, grace, and more money Episode 293 - Sunny Vanderbeck: Long horizon value creation and building businesses that deserve to last Episode 350 - Tom Dillon: Capital strategy, alternative funding sources, and when not to take venture money Social Media Follow DealQuest Podcast: LinkedIn: https://www.linkedin.com/in/coreykupfer/ Website: https://www.coreykupfer.com/ Follow David Horwich: Website: https://horwichadvisors.com LinkedIn: https://www.linkedin.com/in/david-horwich-9317b56/ Keywords/Tags investment banking, growth consulting, exit planning, market check, three ways to grow a business, think like a buyer, enterprise value, middle market M&A, Van Kasper & Company, Odwalla IPO, private equity, capital raising, business valuation, optionality, strategic growth planning, buy versus build, workers comp captive, privately held businesses, Los Angeles M&A advisor, deal-driven growth

Episode 501 - Michael Jones Pete's Percussion Podcast New York-based Percussionist, Recording Artist, Researcher and Educator Michael Jones stops by to talk about his current teaching job at Bard College (NY) and his work throughout the school (04:40), how his graduate studies at UC-San Diego influenced his solo CD projects (17:30), his philosophical research on ontology and percussion instrument ideology and modernity, and questions about what “total percussion” means today (30:30), growing up in Connecticut, his progressive metal music background, high school band, and his involvement in the Live Action Role-Playing community (58:25), his undergrad years at the Hartt School of Music (CT) and studying under Ben Toth and many of the other faculty there (01:12:45), more about his graduate work at UCSD, studying under Steven Schick, and many of his UCSD student colleagues (01:25:35), and settles in for the Random Ass Questions, including segments on the impact of YouTube on young musicians, discussions of mental health, metal music, great books, and the San Diego Superbloom (01:39:40).Finishing with a Rave on the 2026 documentary Earth, Wind & Fire (02:08:20).Michael Jones Links:Michael Jones' websiteMichael Jones' Bard College pageMichael Jones' DiscographyPrevious Podcast Guests mentioned:Steven Schick from 2025Rebecca Lloyd-Jones from 2022Nicholas Papador from 2024Other Links:Eric Cha-BeachJason TreutingNicholas DeyoePluto BellScott WollschlegerSun RaThurman Barker“Psappha” - Iannis XenakisThe Percussionist's Art - Steven SchickAmy CiminiUnsound Supplies - Fanny Gribenski (editor)Anthropocene PeriodWriting the Implosion - Joseph DumitBetween the Buried and MeProtest the HeroScale the SummitPeripheryFred HingerBen TothJoe GaleotaJohn AmiraShane ShanahanTed PiltzeckerRogerio BoccatoFrom Me Flows What You Call Time - Toru TakemitsuPercussion Group CincinnatiHerbert BrünBill Solomon“Thirteen Ways of Looking at a Blackbird” - Lukas FossWilliam Winant“Bone Alphabet” - Brian Ferneyhough“Persephassa” - Iannis XenakisZen and the Art of Archery - Eugene HerrigelFiona DigneyPrincess Mononoke trailerStar Wars: The Last Jedi trailerRakesfall - Vajra ChandrasekeraSwann's Way - Marcel Proust (Lydia Davis translation)MeshuggahSan Diego SuperbloomNardelli'sZetsu No. 8 - Nishida JunRaves:Earth, Wind & Fire documentary trailer

One year from now, a new era begins for UC San Diego as the Tritons join the West Coast Conference. On episode 130 of Tritoncast, we sit down with WCC Commissioner Stu Jackson. We'll get into the Tritons' move to the WCC on July 1, 2027 and why UC San Diego was such a perfect fit for the conference. We'll chat about how his role has evolved with so much change in college athletics in recent years and get his thoughts on the NCAA Tournament expansion to 76 teams. We'll also explore his time at the Big East and working for David Stern at the NBA, and what it was like starting an NBA franchise north of the border in Vancouver. Stu also reflects on an all-star staff he assembled for a March Madness run when he was head coach at Wisconsin. As always, host Jeff Tourial takes us around campus for the latest in Triton Athletics. Check out the feature on recent grade Sophia Bell and her love for open water swimming; 14 from baseball are playing in summer leagues; and the 2026-27 men's and women's basketball rosters are now on UCSDTritons.com.  If you enjoy this week's show, please subscribe, rate, and write a brief review on your favorite podcast platform. Listen to past episodes anytime on-demand at ucsdtritons.com/podcasts. For show updates, follow @Tritoncast on X. Go Tritons!

On episode 129 of Tritoncast, it's another look at Tritons in the Pros. We've brought you conversations with pro baseball players, pro basketball players, and pro water polo players. But this week, it's a new level for Tritoncast as we catch up with the first two former UC San Diego tennis players to hit the pro pickleball tour. Naomi Nguyen and Daniel Traxler will tell us what it's like earning a paycheck in the fastest-growing sport in the country, the mental and physical differences between tennis and pickleball, which skills translate from one court to the other, favorite memories as a Triton, and more. You can keep up with their Carvana PPA Tour adventures on Instagram @naominguyen.pb and @danieltrax01. As always, host Jeff Tourial takes us around campus for the latest in Triton Athletics. Check out the feature on women's soccer goalkeeper Ginny Fronk, who is a cancer survivor, a dozen from track and field earned academic honors, and UC San Diego men's and women's soccer tickets are on sale. If you enjoy this week's show, please subscribe, rate, and write a brief review on your favorite podcast platform. Listen to past episodes anytime on-demand at ucsdtritons.com/podcasts. For show updates, follow @Tritoncast on X. Go Tritons!

This week, host Sam Ko goes upstream from our usual clinical and business topics to sit down with Dr. Roberto Malinow, emeritus professor at UC San Diego, member of both the National Academy of Sciences and the National Academy of Medicine, and one of the world's leading researchers on synaptic plasticity and NMDA receptor biology. His work has been cited more than 30,000 times, and his recent perspective piece takes a very different view of what's actually happening during a ketamine infusion.The core of this conversation is his hypothesis that ketamine works by selectively weakening hyperactive brain circuits, but only the ones actively firing while the drug is on board. It's a finding that raises some genuinely uncomfortable questions about the standard set and setting approach, and points to chronic pain treatment as a practical place to start testing these ideas clinically.You'll also hear about the brain's "disappointment center," the lateral habenula, and why it may be hyperactive in depression, the Stanford anesthesia study and what it suggests about brain activity during treatment, and a wide ranging look at consciousness, optogenetics, the gut-brain connection, and what basic science still doesn't fully understand about how psychiatric drugs work.What You'll Learn in This Episode· Revolutionary ketamine mechanism - How Dr. Malinow's hypothesis suggests ketamine works by weakening hyperactive brain circuits, but only when those specific circuits are actively firing during treatment· The disappointment center concept - Understanding the lateral habenula as the brain's disappointment center that inhibits dopamine and may be hyperactive in depression, serving an evolutionary purpose in reinforcement learning· Challenge to set and setting orthodoxy - How activating negative thoughts or painful experiences could possibly enhance therapeutic outcomes· Neuroplasticity fundamentals - How synapses can be rapidly modified and why NMDA receptors are crucial for both strengthening and weakening neural pathways, forming the basis for learning and memory· Rapid vs. delayed therapeutic effects - Why ketamine can work almost immediately while traditional antidepressants take weeks, and what this reveals about different mechanisms of action· Chronic pain treatment implications - How activating pain circuits during ketamine infusions might be more effective than current protocols, and why chronic pain could be the ideal testing ground for this hypothesis· Basic science translation - How laboratory findings about synaptic plasticity and NMDA receptors connect to real-world therapeutic applications in depression, PTSD, and pain management· Optogenetics technology - How scientists can now deliver light-sensitive proteins to specific neurons, allowing precise activation or inactivation of brain circuits to study behavior and memory· Memory manipulation research - Fascinating studies showing how specific memories can be turned on and off using targeted brain stimulation, with implications for trauma and addiction treatment· Consciousness and synaptic function - Exploring the complex relationship between individual neurons and higher-order brain functions, and why bridging these levels remains challengingEpisode 59 show notes:00:00:00 Teaser: Those hyperactive circuits…00:00:24 Episode Introduction and Guest Overview00:01:12 Sam Introduces and Welcomes Dr. Roberto Malinow00:02:41 Background: From Reed College to The MD/PhD Path00:05:17 Why Basic Science Won Out Over Clinical Medicine00:06:06 The Lecture That Started It All: Professor Rodolfo Llinás and Synapses00:06:51 How Ketamine Interacts with the NMDA Receptor00:07:47 The "Disappointment Center": What the Lateral Habenula Does and Why It Matters in Depression00:09:16 The Standard Set and Setting Approach in Outpatient Ketamine Clinics00:10:12 The Three-Part Hypothesis: Neuroplasticity, Hyperactive Circuits, and Negative Thoughts00:11:49 Written Exposure Therapy and PTSD: Priming Circuits Before the Infusion00:12:53 Chronic Pain as the Easier Testing Ground for the Hypothesis00:14:20 Activating the Pain Pathways During a Ketamine Infusion00:17:23 The Anesthesia Study (Heifets/Stanford): Why the Brain Needs to Be Active00:18:48 What Would a Human Study Design Actually Look Like?00:20:41 Animal Study Evidence Supporting the Active-Stimulus Hypothesis00:21:33 Zooming Out: Synapses, Consciousness, and the Shakespeare Analogy00:23:18 Optogenetics Explained: Using Light to Control Specific Neurons00:27:31 What Don't We Understand About Depression?00:28:29 Lateral Habenula in Animal Depression Models and Dr. Malinow's Own Experiments00:29:13 The Dystopian Scenario: Using Ketamine-Like Drugs to Wipe Out Ideas00:31:31 Common Misconceptions Clinicians Have About Synapses00:32:47 What Surprised Dr. Malinow Most About Studying Synapses00:35:15 Why Ketamine Works Rapidly While SSRIs Take Weeks00:37:30 The "Party Trick": Learning Is Neuroplasticity in Real Time00:39:13 NMDA Receptors and Their Role in Learning and Memory00:39:47 Optogenetics Research: Turning Fear Memories On and Off in Animals00:42:08 Glutamate: 90% of Synaptic Transmission Explained00:43:55 Synapses in the Gut: The Enteric Nervous System00:45:58 The Gut-Brain Connection and Future Research00:46:23 Papers Worth Reading in the Ketamine Space00:47:50 The Psychedelic Renaissance: Psilocybin, the Disappointment Center, and What's Next00:50:20 Could the Activation Hypothesis Apply to Psilocybin and MDMA as Well?00:52:57 Rapid-Fire Questions Begin00:53:19 Time Travel00:54:19 Hidden Talent00:54:48 Alternate Career00:55:42 Advice to 18-Year-Old Roberto00:56:29 Final Thoughts and Call to Action for Clinicians00:57:00 Where to Find Dr. Malinow's Research (UCSD Website)00:57:40 Sam's Closing Remarks00:58:32 Episode EndingThanks for listeningConnect with Dr. Malinow:Website: https://biology.ucsd.edu/research/faculty/rmalinowEmail: rmalinow@ucsd.edu

What if your brain doesn't produce consciousness any more than a radio produces the music? My guest today is Dr. Arnaud Delorme, a computational neuroscientist at UC San Diego and the Institute of Noetic Sciences. He wires up Tibetan monks and mediums to see what actually happens in their brains. When a medium connects with a loved one on the other side, he expected brain activity to spike. Instead, it went almost silent. The more accurate they were, the more their working memory shut down. As if the information wasn't coming from inside them at all. Arnaud started asking "why am I here?" at 11 years old. He has spent decades risking his career to challenge the idea that your thoughts and choices mean nothing. This conversation is about data, non-local consciousness, and what happens when science finally looks beyond the skull. 00:00 The 11-Year-Old Who Asked "Why Am I Here?" 03:09 Welcome Arnaud Delorme 04:12 From Firefighter to Neuroscientist 07:00 The Reductionist Pyramid (And Its Limits) 12:36 Quantum Mechanics: Shut Up and Calculate 16:27 How Science Finally Opened Up to Consciousness 18:33 EEGLAB and Studying Mediums 22:45 Split-Brain Patients and the "Real Illusion" 25:54 The Alternative Hypothesis: You Are More Than Your Brain 30:27 Why Most Scientists Still Need More Data 35:21 The EEG Finding: Accurate Readings Shut Down Working Memory 38:30 Mind Wandering vs. Daydreaming (And a Button in Your Hand) 43:24 Can Meditation Decrease Mind Wandering? Yes. 48:39 Is AI Conscious? (No. But Could It Be? Yes.) 53:33 Arnaud's Fiction Book "The Noetic Particle" + Where to Find Him 55:39 Closing LEARN MORE ABOUT GUEST:· Website: arnauddelorme.com· Institute: noetic.org· Academic Book: (on mind wandering / EEG)· Fiction Book: The Noetic Particle (hard science fiction about AI and consciousness)· Software: EEGLAB (open-source EEG analysis tool) JOIN MY COMMUNITY In The Space Between membership, you'll get access to LIVE quarterly Ask Amy Anything meetings (not offered anywhere else!), discounts on courses, special giveaways, and a place to connect with Amy and other like-minded people. You'll also get exclusive access to other behind-the-scenes goodness when you join! Click here to find out more --> https://shorturl.at/vVrwR Stay Connected: - Instagram - https://tinyurl.com/ysvafdwc- Facebook - https://tinyurl.com/yc3z48v9- YouTube - https://tinyurl.com/ywdsc9vt- Website - https://tinyurl.com/ydj949kt Life, Death & the Space Between Dr. Amy RobbinsExploring life, death, consciousness and what it all means. Put your preconceived notions aside as we explore life, death, consciousness and what it all means on Life, Death & the Space Between.**Brought to you by:Dr. Amy Robbins | Host, Executive ProducerPodcastize.net | Audio & Video Production | Hosted on Acast. See acast.com/privacy for more information.

Recently, Professor Avi Loeb was tasked by the White House, AARO, ODNI, and the FBI with assembling and leading a new UAP Science Advisory Council — comprising astrophysicists, AI experts, and psychologists — to advise the intelligence community on unidentified anomalous phenomena. It was announced the same week the government released its third batch of declassified UAP files. Now he joins us live to talk about what that actually means — and what it doesn't. This is not a "the aliens are here" stream. It's the harder conversation. I study the cosmic microwave background, and when we find an anomaly, we exhaust every instrument artifact and foreground before anyone whispers "new physics." I want to know why UAP science should run on a different evidentiary standard — and Loeb is exactly the right person to push on it, because he's already attributing much of the released footage to cosmic rays, balloons, and possibly Chinese drones, while holding the door open for the small fraction that stays unexplained. WHAT WE GET INTO: - The council, its mandate, and the question nobody's asking: does "advisory" mean anyone has to listen? - The orbs — Chinese surveillance drones, classified US tech, or something else — and the prior you'd need before you say "non-human" - Whether "absence of evidence is not evidence of absence" gets applied selectively - AI in the Galileo Project's detection pipeline, and the false-positive problem: what's the training comparison class for "non-human technology"? - The critique that a council built to study the object ignores where the data actually comes from — human witnesses GUEST: Professor Avi Loeb — Frank B. Baird Jr. Professor of Science at Harvard, former chair of the Astronomy department, head of the Galileo Project, author of "Extraterrestrial" and "Interstellar." Avi on X: https://x.com/ProfAviLoeb Avi's Medium: https://avi-loeb.medium.com Galileo Project: https://galileoproject.org HOST: Brian Keating — experimental cosmologist, UC San Diego. Brian on X: https://x.com/briankeating Brian's Medium: https://drbriankeating.medium.com/ Loeb's essay "Keeping Our Eyes on the Orbs, Not the Audience": https://avi-loeb.medium.com CHAPTERS: 00:00 — "Chinese drones, or the biggest discovery in history?" 00:10 — Avi Loeb, live 00:40 — The White House just put him in charge of UAPs 10:00 — Legitimacy, or a gilded cage? 13:00 — The orbs: Chinese drones or something else? 24:00 — The prior: what's your base rate for "non-human"? 28:00 — The CMB standard: how a cosmologist kills an anomaly 33:00 — AI, SETI, and the false-positive problem 44:00 — Two cosmologists, one Nobel, one council 47:00 — Lightning round 50:00 — The Impossible Question #uap #AviLoeb #UFO #Astrophysics #GalileoProject #SETI #IntoTheImpossible Learn more about your ad choices. Visit megaphone.fm/adchoices

First, in today's episode we'll tell you what changed or stayed in regards to funding for the city of San Diego's police and fire departments in the upcoming fiscal year budget. Then, UC San Diego researchers are looking into whether popular medicines for weight loss could also help to slow the impacts of aging. Also, a new solar panel project in Imperial Beach. And, we'll tell you why the San Diego City Council recently put its support behind a package of state bills aimed at reforming utility companies like SDG&E.

In this episode, Andrew sits down with Naya to discuss her volleyball journey from a young athlete in Hawai‘i to competing at the Division I level. Naya shares how she first discovered volleyball after trying several sports as a child, the impact of club volleyball and travel tournaments on her development, and how competing alongside and against high-level athletes helped her realize that playing collegiate volleyball was possible. She also reflects on growing up in Hawai‘i's year-round volleyball culture and the lessons learned through training, competition, and pursuing goals at increasingly higher levels.The conversation explores the recruiting process, her commitment to the University of Utah, and the excitement surrounding her high school career as she continued to develop as both an athlete and person. However, her journey was far from straightforward. Naya shares the challenges of sustaining an ACL injury and surgery during her sophomore year of high school, only to later suffer an ACL injury to her opposite knee during her senior season. She discusses the physical, mental, and emotional challenges of rehabilitation, staying connected to her team, communicating with college coaches throughout the recruiting process, and learning to focus on what she could control each day.Throughout the episode, Naya provides an honest look at resilience, patience, and perseverance during some of the most difficult moments of her athletic career. She discusses returning to the court, rebuilding confidence in her body, continuing to pursue her goals, and eventually competing at both the University of Utah and UC San Diego. These experiences not only shaped her as an athlete but also inspired her passion for helping others, ultimately leading her toward a career in physical therapy. Whether you're an athlete, coach, parent, or healthcare professional, this episode offers valuable lessons on overcoming adversity, pursuing long-term goals, and finding growth through life's challenges. Enjoy the episode!

If your mom was diagnosed with Alzheimer's, you may already be wondering, “Am I next?” But if your dad, husband, brother, or partner is the one you're worried about, this episode is for you too.Amy breaks down the differences in Alzheimer's risk in women and men, including why women carry more modifiable risk factors, why certain risk factors may hit women's cognition harder, and why Alzheimer's may show up in men in ways that can blindside you.What to Listen For[00:00] Why this episode is for women and the men they love [02:00] Why “early is everything” in Alzheimer's prevention [05:00] Why women's Alzheimer's risk is not just about longevity [07:00] The UC San Diego study findings that surprised researchers [10:00] The 13 modifiable dementia risk factors studied [12:00] Who carries more risk factors versus who is more affected by them[15:00] How BMI affects cognitive performance differently in women vs men [18:00] What you need to know about the effects of cholesterol management [22:00] How heart health affects Alzheimer's risk in men[27:00] What behavioral symptoms show up more often in men with Alzheimer'sOver 7.2 million adults in the U.S. have clinical Alzheimer's, and 2 out of 3 are women. But men are not immune, and there are significant differences. Knowing what they are and which modifiable risk factors to pay attention to means more effective prevention as well as treatment. Listen to the full episode, subscribe to Happy and Healthy with Amy, and download Amy's free RESTORED Protocol guide so you can start building an Alzheimer's-resistant brain—one habit at a time.RESOURCES:Book a FREE Discovery Call with AmyDownload After Mom's Alzheimer's Diagnosis: The First 8 Things to Know and learn how to support her with more calm, clarity, and confidence.Download the RESTORED Protocol: Eight Essential Protective Factors to Build an Alzheimer's-Resistant BrainSchedule your Breakthrough Roadmap session with AmyFollow Amy on Instagram @amylangcoaching  and on Facebook @amylangcoachingSubscribe to Amy's YouTube channel @happyandhealthywithamy

A practicing astrophysicist who doesn't believe in the tunnel of light, the hovering soul, or the wailing relatives — but believes in one near-death experience that changed science forever. By the end you'll believe in it too. Today on Into the Impossible: the strangest, darkest, most personal origin story behind the world's most famous prize — and what it should make you do with the time you have left.

What if the same brain states people spend years chasing through psychedelics could be accessed through meditation alone, and in as little as seven days? In this fascinating solo episode, Darin Olien explores groundbreaking new research from University of California San Diego, Harvard University, Massachusetts General Hospital, and University of Montreal suggesting that meditation may produce brain patterns remarkably similar to those observed during psychedelic experiences. From the suppression of the default mode network and increases in neural complexity to neuroplasticity, endogenous opioids, and measurable biological changes in the bloodstream, Darin unpacks the science behind one of the most powerful, and completely free tools available to human beings. He also walks listeners through a practical seven-day protocol combining focused-attention meditation, Vipassana, breathwork, walking meditation, and loving-kindness practices designed to help cultivate greater awareness, emotional resilience, cognitive flexibility, and inner peace. What You'll Learn The groundbreaking UC San Diego meditation study and its surprising findings Why meditation may create brain states similar to psilocybin What the default mode network is and how it shapes everyday thinking How meditation may reduce rumination, anxiety, and self-referential thought The concept of brain criticality and cognitive flexibility Why post-meditation blood samples stimulated neuronal growth How meditation influences neuroplasticity and whole-body biology The differences between Samatha and Vipassana meditation What advanced monks are teaching scientists about consciousness The limitations and caveats of current meditation research A practical seven-day meditation protocol anyone can begin Why meditation may be one of the most powerful health interventions available today Chapters 00:00:03 – Welcome to SuperLife 00:00:33 – Sponsor: Alkemis and the hidden toxicity of indoor air 00:00:57 – Conventional paints, petrochemicals, and endocrine disruptors 00:01:24 – Why VOCs and PFAS may be affecting your home environment 00:01:55 – Fire-resistant mineral paints and healthier living spaces 00:02:27 – Cradle to Cradle certification and sustainable design 00:03:23 – The meditation study Darin can't stop thinking about 00:03:33 – Scanning the brains and blood of meditators 00:03:44 – Brain activity resembling psilocybin experiences 00:04:09 – The promise of a seven-day meditation protocol 00:04:22 – Psychedelics, consciousness, and dissolving the sense of self 00:04:47 – Ancient practices and modern scientific validation 00:05:23 – Why meditation research is entering a renaissance 00:05:41 – Harvard, Massachusetts General Hospital, and advanced consciousness mapping 00:06:00 – University of Montreal's study of monks with 15,000+ hours of practice 00:06:16 – Why psychedelics and meditation are converging scientifically 00:06:37 – What listeners will learn in today's episode 00:06:54 – Breaking down the UC San Diego retreat study 00:07:18 – Thirty-three hours of meditation, breathwork, and group practice 00:07:42 – EEG scans, blood draws, and laboratory neuron testing 00:08:05 – Reduced activity in the default mode network 00:08:24 – The science of mental chatter and rumination 00:08:50 – Blood plasma stimulating new neuronal growth 00:09:02 – Neuroplasticity and new neural connections 00:09:29 – Increased cellular metabolism and endogenous opioids 00:10:13 – Samatha vs Vipassana meditation explained 00:10:42 – How different meditation styles reshape the brain 00:10:50 – Harvard's advanced meditation consciousness studies 00:11:18 – Mapping concentration states and consciousness cessation 00:11:46 – Ancient contemplative traditions meeting modern neuroscience 00:11:50 – Important limitations of the research 00:12:05 – Why advanced monks aren't average practitioners 00:12:20 – Correlation versus causation in psychedelic comparisons 00:12:48 – What may actually be happening inside the brain 00:13:03 – Understanding the default mode network 00:13:26 – Anxiety, depression, addiction, and overactive self-talk 00:13:53 – Why meditation and psilocybin share common neurological effects 00:14:10 – Beginner studies showing measurable brain changes 00:14:28 – Brain criticality and cognitive adaptability 00:14:48 – The most surprising finding: meditation changes the blood 00:15:05 – Meditation as a whole-body signaling event 00:15:18 – Better sleep, digestion, hormone balance, and recovery 00:15:39 – Neuroplasticity, immune function, metabolism, and pain regulation 00:15:56 – Why meditation may be the ultimate free medicine 00:16:10 – Introducing the seven-day meditation protocol 00:16:34 – Sponsor break: Alkemis Paint 00:19:02 – Building a research-backed at-home meditation practice 00:19:24 – Why consistency matters more than total hours 00:19:41 – Combining focused attention and open monitoring 00:19:53 – Days 1–3: Stabilizing attention 00:20:02 – Morning focused-attention meditation instructions 00:20:34 – Evening body scan practice 00:21:04 – Preparing the brain for deeper awareness 00:21:08 – Days 4–5: Opening awareness through Vipassana 00:21:31 – Letting thoughts, sensations, and sounds pass freely 00:21:39 – Evening box breathing for nervous system regulation 00:22:01 – Why days four and five often feel more challenging 00:22:11 – Days 6–7: Deepening and integrating the practice 00:22:27 – Walking meditation and embodied awareness 00:22:52 – Loving-kindness meditation and compassion training 00:23:02 – Vagal tone, heart rate regulation, and inflammation reduction 00:23:18 – Three rules that determine success 00:23:26 – Eliminating distractions and protecting attention 00:23:36 – Why you should never judge your meditation sessions 00:24:00 – Extending the practice beyond seven days 00:24:19 – Psychedelics, meditation, and the search for transformation 00:24:51 – What the medicine always teaches: sit with yourself 00:25:03 – The wellness industry's tendency to monetize stillness 00:25:20 – Why you don't need expensive tools to transform 00:25:36 – Meditation as radical self-reclamation 00:26:02 – Meeting yourself without distraction 00:26:17 – Final reflections and closing thoughts 00:26:29 – Outro and farewell Thank You to Our Sponsors Alkemis: Go to https://alkemispaint.com/ and use code DARIN10 for 10% off your order. Manna Vitality: Go to mannavitality.com/ and use code DARIN12 for 12% off your order. Join the SuperLife Patreon: This is where Darin now shares the deeper work: - weekly voice notes - ingredient trackers - wellness challenges - extended conversations - community accountability - sovereignty practices Join now for only $7.49/month at https://patreon.com/darinolien Find More from Darin Olien: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Platform & Products: superlife.com New Show: Roadmap to Happiness Key Takeaway "Perhaps one of the most profound discoveries emerging from modern neuroscience is that many of the states of awareness humans have sought through substances, rituals, and external interventions may already be available within us. Meditation is not simply a relaxation practice—it appears to be a biological, neurological, and consciousness-altering intervention capable of reshaping the brain, changing the body, and transforming how we experience reality. The question is not whether the door exists. The question is whether we are willing to sit still long enough to walk through it." Bibliography/Sources: Here is the fully formatted bibliography for the "Seven Days to a New Brain" episode. It is organized by category, formatted in strict APA Style (7th Edition), and includes a direct link for every single source : Primary Studies Brewer, J. A., Worhunsky, P. D., Gray, J. R., Tang, Y. Y., Weber, J., & Kober, H. (2011). Meditation experience is associated with differences in default mode network activity and connectivity. Proceedings of the National Academy of Sciences, 108(50), 20254–20259 . https://doi.org/10.1073/pnas.1112029108 Lieberman, J. M., Rahrig, H., Britton, W. B., et al. (2025). Toward a neuroscience of consciousness using advanced meditation. Neuroscience & Biobehavioral Reviews . https://meditation.mgh.harvard.edu/files/Lieberman_25_NeuroscienceAndBiobehavioralReviews.pdf Pascarella, A., Jerbi, K., et al. (2026). Meditation induces shifts in neural oscillations, brain complexity, and critical dynamics: Novel insights from MEG. Neuroscience of Consciousness . https://pubmed.ncbi.nlm.nih.gov/41287816/ Patel, H., et al. (2025). Intensive meditation retreat induces rapid changes in brain activity, blood-based biomarkers, and neurotrophic signaling. Communications Biology . https://today.ucsd.edu/story/meditation-retreat-rapidly-reprograms-body-and-mind Shinozuka, K., et al. (2025). Neuroelectrophysiological correlates of extended cessation of consciousness in advanced meditation [Preprint]. bioRxiv . https://meditation.mgh.harvard.edu/files/Shinozuka_25_bioRxiv.pdf Van Lutterveld, R., et al. (2025). An intensively sampled electroencephalography case study of advanced concentration absorption meditation (jhana) [Preprint]. SSRN . https://meditation.mgh.harvard.edu/files/VanLutterveld_25_SSRN.pdf Supporting Press Coverage & Explainers Harvard Gazette. (2026, January). Your brain on advanced meditation . https://news.harvard.edu/gazette/story/2026/01/your-brain-on-advanced-meditation/ Medical Xpress. (2026, February). Study of 12 monks finds meditation heightens brain activity, reshaping neural dynamics . https://medicalxpress.com/news/2026-02-monks-meditation-heightens-brain-reshaping.html PsyPost. (2026). Brain scans of Buddhist monks reveal how different meditation styles alter consciousness . https://www.psypost.org/brain-scans-of-buddhist-monks-reveal-how-different-meditation-styles-alter-consciousness/ ScienceDaily. (2026, April 6). Scientists say 7 days of meditation can rewire your brain . https://www.sciencedaily.com/releases/2026/04/260406192913.htm UC San Diego Today. (2026). Meditation retreat rapidly reprograms body and mind. UC San Diego News Center . https://today.ucsd.edu/story/meditation-retreat-rapidly-reprograms-body-and-mind Université de Montréal. (2026, January 5). Meditation doesn't rest the brain, it reshapes it. UdeMNouvelles . https://nouvelles.umontreal.ca/en/article/2026/01/05/meditation-doesn-t-rest-the-brain-it-reshapes-it  

An experimental cosmologist with 35 years of CMB research breaks down the curvature tension — and why the viral claim that "everything we know about cosmology is wrong" doesn't survive contact with the actual data. Subscribe if you want science with evidence, not speculation. Dr. Brian Keating is Chancellor's Distinguished Professor of Physics at UC San Diego and one of the leading experimental cosmologists working on the cosmic microwave background. He has spent three decades on experiments including BICEP, BICEP2, the Simons Array, and the Simons Observatory — the same data ecosystem at the center of this debate. We cover: why a statistical preference in one dataset is not the same as a discovery, what Planck actually measured and what its curvature signal does and doesn't mean, why combining CMB data with baryon acoustic oscillations changes the picture, the difference between geometry and topology that most explainers skip, and why science communicators who sensationalize real tensions do more damage than they realize. A clickable title and a photogenic host are not the same thing as a careful inference from the data. Key Takeaways: 00:00 A flat universe means the angles of any triangle in space sum to exactly 180° 02:10 Zero curvature is a unique number — it demands explanation, which is part of why inflation matters 04:45 Geometry describes how space behaves at scale; topology is a separate question most explainers conflate 07:30 Planck's curvature preference appears in some analyses — it is real, but it is also model-sensitive 10:00 A statistical preference within one dataset is not a confirmed result 12:20 Parameter degeneracy means changing one cosmological knob shifts others — results are not isolated 14:40 When Planck data is combined with baryon acoustic oscillation data, the case for curvature weakens 17:00 The honest summary: the curvature tension is worth watching, but nowhere near decisive 18:30 Sensationalizing legitimate tensions trains the public to think science only matters when it's exploding ———

California's $20 fast-food minimum wage cut employment by roughly 18,000 jobs and pushed up restaurant prices. Cato's Ryan Bourne talks to UC San Diego economist Jeff Clemens about California's wage-floor experiment—and the broader lessons for state and federal minimum wage policy. Hosted on Acast. See acast.com/privacy for more information.