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In this episode, we review the high-yield topic of Salmonella typhi from the Microbiology section. Follow Medbullets on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbull --- Send in a voice message: https://podcasters.spotify.com/pod/show/medbulletsstep1/message
Join Jame and Callum as they discuss the two titans of diarrhoea, Salmonella and Shigella. Who knew Salmonella species were so complex? Jame explains something that will SHOCK you about Shigella (maybe).Review of Salmonella: Shu-Kee Eng, Priyia Pusparajah, Nurul-Syakima Ab Mutalib, Hooi-Leng Ser, Kok-Gan Chan & Learn-Han Lee (2015) Salmonella: A review on pathogenesis, epidemiology and antibiotic resistance, Frontiers in Life Science, 8:3, 284-293, DOI: 10.1080/21553769.2015.1051243Original article on Edinburgh S. Typhi outbreak investigation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2130034/pdf/jhyg00084-0045.pdf
https://www.ncbi.nlm.nih.gov/books/NBK519002/ --- Send in a voice message: https://anchor.fm/las-poderosas-celulas-nk/message
Vincent meets up with Stan Maloy on the campus of San Diego State University to talk about his career in microbiology and his work as Dean of Science.
Vincent meets up with Stan Maloy on the campus of San Diego State University to talk about his career in microbiology and his work as Dean of Science.
Hosts: Vincent Racaniello. Special guest: Stanley Maloy Vincent meets up with Stan Maloy on the campus of San Diego State University to talk about his career in microbiology and his work as Dean of Science. Subscribe to TWiM (free) on iTunes, via RSS feed, by email or listen on your mobile device with the Microbeworld app. Links for this episode: Maloy lab Salmonella.org Microbial genetics course page Typhoid Mary Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.
Vincent visits the San Diego State University campus and talks with Dean of Sciences, Stanley Maloy about his career in microbiolgy and his job as Dean.
Medizinische Fakultät - Digitale Hochschulschriften der LMU - Teil 11/19
Fri, 22 Jan 2010 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/10848/ https://edoc.ub.uni-muenchen.de/10848/1/Winter_Sebastian.pdf Winter, Sebastian
Bacterial pathogens causing systemic disease commonly evolve from organisms associated with localized infections but differ from their close relatives in their ability to overcome mucosal barriers by mechanisms that remain incompletely understood. Here we investigated whether acquisition of a regulatory gene, tviA, contributed to the ability of Salmonella enterica serotype Typhi to disseminate from the intestine to systemic sites of infection during typhoid fever. To study the consequences of acquiring a new regulator by horizontal gene transfer, tviA was introduced into the chromosome of S. enterica serotype Typhimurium, a closely related pathogen causing a localized gastrointestinal infection in immunocompetent individuals. TviA repressed expression of flagellin, a pathogen associated molecular pattern (PAMP), when bacteria were grown at osmotic conditions encountered in tissue, but not at higher osmolarity present in the intestinal lumen. TviA-mediated flagellin repression enabled bacteria to evade sentinel functions of human model epithelia and resulted in increased bacterial dissemination to the spleen in a chicken model. Collectively, our data point to PAMP repression as a novel pathogenic mechanism to overcome the mucosal barrier through innate immune evasion.