Podcasts about Frontiers

One thing that a lot of people with vestibular disorders notice is how fatiguing or challenging different tasks become over time.  What's happening is your brain is trying to process multiple inputs (or even tasks) at the same time.  For those with vestibular disorders, it becomes more difficult because your body is trying to process more information—and it’s also now having to work double time to keep you upright. Multitasking and task switching are a part of daily life, but it comes with costs. And those with vestibular disorders often notice this more but aren't quite sure how to make it go away. But this episode is here to help! In this episode, we'll dig into: Why tasks feel manageable alone but become overwhelming when combined How multitasking and task switching are similar and different What the “switch cost” is and how it adds up over time for those with vestibular disorders What percentage of people with vestibular conditions experience cognitive symptoms like brain fog How the central nervous system and cerebral cortices matter for cognitive symptoms Why spatial awareness demands extra resources when you have a vestibular disorder How balance exercises in VRT are designed to gradually scale up task demands Why errors are actually part of healing with a vestibular condition Why rest and recovery are essential when you’re adding in more cognitive or physical tasks Task switching and multitasking are hard for everyone! A vestibular disorder just adds an extra layer—it doesn’t mean things can’t improve, but it does take time, space, and grace. You're doing more things than you think and certainly doing more than you take credit for. Links Mentioned: Vestibular Group Fit (code GROUNDED at checkout for 15% off!): https://thevertigodoctor.com/vestibular-group-fit Free Resources: ⁠The 4 Steps to Managing Vestibular Migraine: https://thevertigodoctor.myflodesk.com/cb5js0y78n ⁠The PPPD Management Masterclass⁠: https://thevertigodoctor.myflodesk.com/new-pppd ⁠What your Partner Should Know About Living with Dizziness⁠: https://thevertigodoctor.myflodesk.com/partnership ⁠The FREE Mini VGFit Workout⁠: https://thevertigodoctor.myflodesk.com/minifit ⁠The FREE POTS – safe Workouts⁠: https://thevertigodoctor.myflodesk.com/pots Connect with Dr. Madison (@TheVertigoDoctor): https://instagram.com/thevertigodoctor Work with Dr. Madison: For 1:1 Vestibular Rehabilitation Therapy, email madison@thevertigodoctor.com Otherwise, I'll see ya in Vestibular Group Fit! Connect with Dr. Jenna (@dizzy.rehab.therapist): https://www.instagram.com/dizzy.rehab.therapist/ Learn about the Oak Method: http://thevertigodoctor.com/why-vestibular-group-fit Love what you heard?Consider leaving a review on your favorite podcast platform to help us reach more vestibular warriors like you! This podcast is for informational purposes only and may not be the best fit for you and your personal situation. It shall not be construed as medical advice. The information and education provided here is not intended or implied to supplement or replace professional medical treatment, advice, and/or diagnosis. Always check with your own physician or medical professional before trying or implementing any information read here. Citations  McGrath, Kim. “The “Switch Cost” of Multitasking.” Wake Forest News, 16 Apr. 2024, news.wfu.edu/2024/04/16/the-switch-cost-of-multitasking/. Asuako, P. A. G., Stojan, R., Bock, O., Mack, M., & Voelcker-Rehage, C. (2025). Multitasking: does task-switching add to the effect of dual-tasking on everyday-like driving behavior?. Cognitive research: principles and implications, 10(1), 5. https://doi.org/10.1186/s41235-025-00611-y Smith, L. J., Wilkinson, D., Bodani, M., & Surenthiran, S. S. (2024). Cognition in vestibular disorders: state of the field, challenges, and priorities for the future. Frontiers in neurology, 15, 1159174. https://doi.org/10.3389/fneur.2024.1159174 ————————————— task switching and multitasking, things to help with brain fog, vestibular migraine brain fog, what causes brain fog and dizziness, vestibular disorders, vestibular group fit, living with vestibular migraine, living with chronic dizziness, sensory overload, spatial awareness, cognitive abilities

What allows some CFOs to lead with influence while others never move beyond the numbers? Today's CFOs are expected to do much more than oversee financial performance. They must build trust, influence executive decisions, communicate with empathy, and help shape company strategy. In this episode, leadership expert and former CFO Dr. Emilia Bunea shares why technical expertise alone isn't enough and explains the mindset and behaviors that help CFOs lead executive teams, boards, and entire organizations more effectively. By listening to this episode, you'll learn how to: Discover why relationship building and influence have become essential skills as CFOs lead beyond traditional finance responsibilities. Learn practical techniques for communicating strategic recommendations in ways that earn buy-in from CEOs, boards, and executive teams. Understand the leadership habits that prepare finance executives to become trusted business leaders and future CEOs. Listen now to learn how CFOs lead with influence, strategic thinking, and emotional intelligence to create stronger organizations and position themselves for greater leadership opportunities. Check out: 05:10 | Why CFOs Lead Through Relationships, Not Just Numbers Dr. Emilia Bunea explains the difference between an accounting leader and a true CFO, revealing why relationship management and influence are what separate finance executives from strategic leaders. 14:35 | Influence Is More Powerful Than Logic Learn why even the strongest financial arguments can fail without emotional engagement, and how CFOs can present ideas that inspire action instead of resistance. 31:10 | Preparing CFOs to Become CEOs Hear the leadership qualities boards look for when evaluating CFOs for the CEO role, including strategic thinking, executive presence, and building trust outside the finance function. About Emilia Bunea Dr. Emilia Bunea, CFA, is a leadership lecturer at VU University Amsterdam and co-founder and CEO of Ed.movie, a California-based edutainment company. She served in CFO and CEO roles at large financial corporations, most recently as CEO of MetLife Romania, and previously as CFO of ING Insurance Europe, and currently serves on the board of directors of an asset management company.  Dr. Bunea received her Ph.D. in Management from VU Amsterdam, her MBA from the University of Washington, and is a CFA charterholder. She delivers lectures and keynotes on leadership at business schools, companies, and events around the world. Her research was published in Human Resource Management Review, Corporate Governance - An International Review, Frontiers in Psychology, Academy of Management Proceedings, and shared through outlets such as Harvard Business Review and Le Monde.  Emilia Bunea is the producer and co-writer of Crossroads Life, the world's first "cinematic management case"—a groundbreaking teaching tool that combines the rigor of the case study method with the storytelling power of film. Based on the real-life leadership journey of a CFO, the film has won multiple international awards (IMDb link). Each chapter of her book, Leadership for the CFO, includes curated film scenes that bring its concepts to life.  

These sources examine the multifaceted impact of artificial intelligence on the global education landscape and the subsequent workforce. Research from Frontiers in Computer Science highlights a growing digital divide, noting that while AI offers personalized learning, it can also perpetuate cultural and linguistic biases against marginalized communities. Conversely, perspectives from Howard University and the University of New Hampshire frame AI as a critical intellectual partner that enhances doctoral research and shifts faculty roles from traditional lecturers to active facilitators. Economic analysis from Stanford further suggests that AI may actually level the professional playing field by simplifying complex tasks, allowing lower-skilled workers to compete for higher wages. Ultimately, the collection argues that inclusive design and proactive training are essential to ensure AI serves as a tool for equity rather than a driver of further stratification.

Welcome to Day 2907 of Wisdom-Trek. Thank you for joining me. This is Guthrie Chamberlain, Your Guide to Wisdom. Day 2907 – Wisdom Nuggets – Psalm 144:1-8 Daily Wisdom Wisdom-Trek Podcast Script - Day 2907 Welcome to Wisdom-Trek with Gramps! I am Guthrie Chamberlain, and we are on Day 2907 of our Trek. The Purpose of Wisdom-Trek is to create a legacy of wisdom, to seek out discernment and insights, and to boldly grow where few have chosen to grow before. The title for today's Wisdom-Trek is: The Cosmic Warrior's Sanctuary – Bowing the Heavens to Rescue Frail Mortals On our previous expedition, on Day Two Thousand Nine Hundred Five, we bore witness to David's heavy, cumulative exhaustion in Psalm One Hundred Forty-Three. We stood alongside him in the dark, feeling the suffocating, numbing weight of a long-drawn-out wilderness campaign, as he pleaded for the morning light of God's unfailing love to rescue his failing spirit. Today, as we crest a magnificent new ridge along our multi-month journey through the psalter, we advance directly into Psalm One Hundred Forty-Four, verses one through eight. This text serves as an incredibly powerful, triumphant answer to the dark paralysis we analyzed in our last study. David is no longer sitting frozen in the dust, wondering if the darkness will permanently consume him. Instead, he bursts forth with a magnificent, high-energy anthem of praise, recognizing that the very hardships he endured were the training grounds for his ultimate destiny. As we explore these eight verses together, we will discover a dynamic mosaic of royal warfare, cosmic geography, and profound theological humility, viewing this entire battlefield through the brilliant, ancient worldview of Yahweh's sovereign heavenly host. The first segment is: The Divine Arsenal: Training for the Frontiers of Chaos Let us open our minds to the opening movements of this royal liturgy, as recorded in the New Living Translation, grouping together the deeply connected, contiguous thoughts found in verse one and verse two. Praise the Lord, who is my rock. He trains my hands for war and gives my fingers skill for battle. He is my loving ally and my fortress, my tower of safety, my rescuer. He is my shield, and I take refuge in him. He subdues the nations under me. David begins this segment with an unshakeable, rhythmic blast of absolute adoration, declaring, “Praise the Lord, who is my rock. He trains my hands for war and gives my fingers skill for battle. He is my loving ally and my fortress, my tower of safety, my rescuer. He is my shield, and I take refuge in him. He subdues the nations under me.” To fully appreciate the vast, panoramic scope of these opening lines, we must view David's military reality through the fascinating, complex lens of the Ancient Israelite divine-council worldview. In the ancient Near East, kingship was never viewed as a purely secular, administrative function. The king of Israel was understood to be the earthly representative, the unique viceroy, of Yahweh Himself. When David addresses God as Yahweh Sabaoth—the Lord of Heaven's Armies—he is recognizing that his earthly battles are intimately intertwined with a grand, unseen cosmic conflict. The hostile surrounding nations were not just political competitors; they were groups aligned with rebellious, territorial spiritual principalities who actively sought to subvert the cosmic order established by the Most High God. Notice that David does not boast in his own inherent athletic prowess, or his natural military genius, even though he was a legendary warrior who defeated giants. Instead, he attributes all of his kinetic capability to his Creator, shouting, "He trains my hands for war and gives my fingers skill for battle." Yahweh is depicted here as the Master Commander, personally mentoring His earthly king, tuning his reflexes, and sharpening his tactical focus so that he can effectively push back the frontiers of chaos. David then layers title upon glorious title, describing God as his rock, his loving ally, his fortress, his tower of safety, his rescuer, and his shield. In the ancient world, a tower of safety or a fortress on a high crag was completely unassailable by infantry. By running into the character of Yahweh, David enters a fortress that sits completely above the reach of both earthly weapons and dark, cosmic forces. It is from this secure, celestial vantage point that the true King of the universe executes judgment, subduing rebellious human assemblies under the feet of His anointed servant. The second segment is: The Radical Contrast: Cosmic Majesty and Fleeting Shadows Right in the middle of this high-stakes military declaration, David pauses to display a stunning level of philosophical and theological humility, combining the logical thoughts found in verse three and verse four. O Lord, what are human beings that you should notice them, mere mortals that you should think about them? For we are like a breath of air; our days are like a passing shadow. David pivots his gaze away from the grand geopolitics of his kingdom to look directly into the mirror of human fragility, asking, “O Lord, what are human beings that you should notice them, mere mortals that you should think about them? For we are like a breath of air; our days are like a passing shadow.” This exquisite, highly poetic exclamation directly echoes the haunting cosmic questions raised in Psalm Eight. As a king who sat in council with the elders, and who regularly contemplated the vast tapestry of the night sky, David was acutely aware of the mind-boggling scale of reality. In the ancient cosmic geography, above the physical dome of the sky rested the glorious, burning palace of the divine council, populated by majestic, immortal spiritual beings who had witnessed the very foundations of the earth being laid. In comparison to these enduring celestial hosts, and in comparison to the eternal, uncreated majesty of Yahweh, what is a human being? David uses two incredibly vivid Hebrew metaphors to describe our mortal condition: hevel—which translates to a mere breath of warm air, a vapor that appears for a microsecond in the winter cold and then vanishes completely—and a passing shadow, like the silhouette of a bird flying over a field, gone before the eye can even track its movement. Yet, the profound mystery of biblical wisdom lies right here in this juxtaposition. The transcendent Sovereign Lord of the cosmos, who rules over billions of stars and commands legions of heavenly messengers, actively chooses to step down into history to notice, think about, and harbor deep affection for these fragile, breathing dust-creatures. He doesn't just tolerate humanity; He partners with mortals, inviting them to participate in the restoration of His cosmic order. The third segment is: Cosmic Theophany: Splitting the Fabric of the Sky Having established both the supreme majesty of God and the radical dependence of man, David now launches into a dramatic, high-impact prayer for an immediate, supernatural intervention, weaving together the cosmic warfare motifs found in verse five and verse six. Open the heavens and come down, Lord. Touch the mountains so they billow smoke. Flash your lightning and scatter your enemies! Shoot your arrows and confuse them! David calls down the ultimate cosmic cavalry, crying out with immense urgency, “Open the heavens and come down, Lord. Touch the mountains so they billow smoke. Flash your lightning and scatter your enemies! Shoot your arrows and confuse them!” This section contains some of the most concentrated, highly dramatic theophany imagery in the entire Old Testament. When David prays, “Open the heavens and come down,” the original language literally means to bow or to bend the heavens. In the ancient mindset, the sky was seen as a solid, physical separation between the celestial realm of God's throne room and the terrestrial realm of human history. David is asking Yahweh to grab the fabric of the cosmos, bend it downward, and rip open the boundary line, invading earthly geography with the raw, unfiltered glory of His heavenly presence. When the Most High steps down, the physical geography of the earth cannot sustain His weight. He touches the mountains—which in the ancient near eastern worldview were considered the pillars of the earth, the cosmic boundary stones where the gods met—and they instantly erupt, billowing smoke like volatile volcanoes, completely unmasked as fragile structures before their Creator. David then describes the weapons of this cosmic combat: lightning bolts functioning as divine spears, flashing across the dark sky to scatter the entrenched armies of the wicked, while supernatural arrows of thunder confuse and disorient the adversaries. This is...

SEGMENTS | Indigenous People and Fort Caroline | The Hurricane of 1811 | 1960s Activist Marshall Jones at UF

Most people think the greatest danger on Mount Everest is the mountain itself. But beginning in 2018, investigators uncovered an alleged $20 million Everest helicopter rescue fraud that exploited trekkers through unnecessary evacuations, forged medical records, and fraudulent insurance claims. By 2026, Nepal's Central Investigation Bureau had filed sweeping criminal charges, exposing one of the biggest scandals in Everest's history. In this episode of Disaster Strikes, Kaycee McIntosh and Julie Henningsen examine how the scheme allegedly operated, why altitude makes trekkers especially vulnerable to manipulation, and how guides, helicopter companies, hospitals, and doctors became caught up in an investigation that shook Nepal's mountaineering industry. The hosts also separate verified facts from sensational headlines, including what investigators actually concluded about the widely reported poisoning allegations. Whether you're planning an Everest Base Camp trek, dreaming of climbing Mount Everest, or simply fascinated by survival stories, this episode explains how the fraud unfolded, why it damaged trust throughout the Himalayas, and what every trekker should know before accepting a helicopter evacuation. In This Episode 00:00 Everest Betrayal Teaser01:15 Everest Trek vs. Summit Climb04:13 The True Cost of Mount Everest08:52 Sherpas, Guides, and Trust at Altitude15:00 How Everest Guides Are Trained18:11 The Helicopter Rescue Fraud Exposed22:48 What Investigators Found About Poisoning Claims27:29 Following the Money31:59 Fallout Across Nepal's Everest Industry35:13 Altitude Sickness & Trekking Safety Tips40:50 Closing Thoughts Sources Nepal Police Central Investigation Bureau (CIB) — 748-page charge sheet (March 2026) The Kathmandu Post — Original 2018 investigation and ongoing coverage Climbing Magazine — Review of the CIB charge sheet (April 7, 2026) Outside Magazine — Everest guiding industry response (April 2026) ExplorersWeb — Analysis of the investigation and media coverage (April 3, 2026) IBTimes UK — Reporting on hospital commission structures (April 2, 2026) NewsNation / The Hill — CIB statement regarding poisoning allegations (April 7, 2026) Alan Arnette — Everest expedition cost analysis (2025) National Geographic — Sherpa culture and Everest commercialization Frontiers in Physiology (NCBI) — Research on cognitive impairment at high altitude Himalayan Database — Khumbu Icefall fatality records Poisoning Allegations: The Nepal Police Central Investigation Bureau's 2026 investigation found no evidence that systematic poisoning was part of the helicopter rescue fraud. While isolated references to baking soda appear in the charge sheet, investigators did not conclude that poisoning was used as a widespread tactic. Media reports describing rat droppings or uncooked chicken were not included as confirmed findings in the formal 748-page charge sheet reviewed by Climbing Magazine. This episode distinguishes verified investigative findings from unconfirmed claims. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

En este episodio conversamos sobre el descubrimiento de la penicilina y cómo un hallazgo inesperado marcó el inicio de la era de los antibióticos. Hablamos del trabajo de Alexander Fleming, el papel que desempeñó la observación científica y cómo este descubrimiento revolucionó el tratamiento de las enfermedades infecciosas, transformando la medicina moderna y salvando millones de vidas en todo el mundo.ReferenciasAminov, R. I. (2010). A brief history of the antibiotic era: Lessons learned and challenges for the future. *Frontiers in Microbiology, 1*, Article 134. https://doi.org/10.3389/fmicb.2010.00134Belloso, W. H. (2011). Historia de la penicilina y su impacto en la medicina moderna. Revista del Hospital Italiano de Buenos Aires, 31(3), 102–111. Artículo en Revista del Hospital Italiano de Buenos AiresEBSCO Research Starters. (s. f.). Ehrlich introduces Salvarsan as a cure for syphilis. EBSCO. Recuperado el 16 de julio de 2026, de EBSCO Research StartersGaynes, R. (2017). The discovery of penicillin—New insights after more than 75 years of clinical use. *Emerging Infectious Diseases, 23*(5), 849–853. https://doi.org/10.3201/eid2305.161556Silver, L. L. (2011). Challenges of antibacterial discovery. Clinical Microbiology Reviews, 24(1), 71–109. https://doi.org/10.1128/CMR.00030-10

Send us Fan MailThis episode originally aired at 1pm on Wednesday July 15 on SiriusXM 129 The Catholic ChannelFrontiers of Faith is now broadcast weekly on SiriusXM and uploaded here immediately after! This is one of Katie's favorite episodes, for what its worth. We talk about great saints celebrating their feasts this week, we talk Bonaventure, we talk mission funding and what's an episode of Frontiers of Faith without some martyr talk?  Click here to learn more about supporting the Pontifical Missions Societies:https://pontificalmissions.orgFollow us on socials!https://x.com/tpms_usa

Comparison at tryouts is costing her more than she realizes. What's Your Competitor Style Quiz → https://athlete.fyi/yt-quiz

Send us Fan MailThe animal that causes the most aggressive wildlife incidents in Canada is probably not the one you're picturing. We break down a Frontiers in Conservation Science study that tracks thousands of encounters and lands on a surprising culprit: elk, especially around campgrounds. We talk through why “cute” and “safe” are not the same thing, how seasonality can change animal behavior, and the simple hiking habits that lower the odds of a scary surprise on the trail, whether you're camping, wildlife watching, or walking with your dog.Then we shift into pet science with a study from Anthrozoos on snakes and kids. The key detail is not just what children think, but how fast a parent's real-time comments can shape fear and “othering.” If you've ever wondered how to talk about animals you dislike without passing that fear on, this part will stick with you.Finally, we're joined by Kathy Plobloski, director of Lost Dogs of Wisconsin, for a practical, science-informed guide to finding missing pets. We cover Pet FBI, why centralized lost and found databases matter, why old-school flyers still reunite the most pets, and the concept of survival mode, where even a bonded dog may avoid you. We also dig into shelters, stray hold timelines, and microchip tips that only work if your info stays updated. If you've ever loved an animal, this conversation is worth saving and sharing. Subscribe, share the episode with a pet parent, and leave us a review so more families can find these tools when they need them.Lost dogs websiteAll our social links are here!Support the showFor Science, Empathy, and Cuteness!Being Kind is a Superpower.All our social links are here!

Bonita macht im Fitnessstudio seit Jahren immer die gleichen Übungen. An neue Geräte traut sie sich nicht dran, aus der Sorge, negativ aufzufallen. Mit der Gym-Anxiety ist sie nicht alleine. Das Fitti macht es einem auch nicht immer einfach.**********Ihr hört: Gesprächspartnerin: Bonita, macht seit dem 16. Lebensjahr die gleichen Übungen, weil ihr das Fitnessstudio unangenehm ist Gesprächspartnerin: Elgen Sauerborn, Emotionssoziologin, Wissenschaftliche Mitarbeiterin, Freie Universität Berlin Gesprächspartnerin: Anna Kramp, Bodybuilding- und Fitnesscoach Autor und Host: Przemek Żuk Redaktion: Lena Mempel, Jana Niehof, Anton Stanislawski, Friederike Seeger Produktion: Cornelia Preißel**********Quellen:Auster-Gussman, L. A., Crim, J., & Mann, T. L. (2021). The soulless cycle: Social physique anxiety as a mediator of the relation between body mass index and exercise frequency. Stigma and Health, 6(2), 192–199.Quinn F. (2026). Understanding social gym intimidation and anxiety using the power-threat-meaning framework. Frontiers in Sports and Active Living, 8:1712367.Penta, C. (2022). Gym Anxiety: How it Affects the Mental Health and Body Image Perception of Female College Students in a Male Dominated Setting. Bryant University Press.Coulter, K. S. (2021). Intimidation and distraction in an exercise context. International Journal of Sport and Exercise Psychology, 19(4), 668–686.Nuffield Health (2024). Healthier Nation Index 2024.**********Mehr zum Thema bei Deutschlandfunk Nova:Körperbild: Wie sieht fit sein aus?Sportsucht: Woran merke ich, dass es zu viel ist?Persönlichkeitstest: Welche Sportart am besten zu dir passt**********Den Artikel zum Stück findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: TikTok und Instagram .**********Meldet euch!Ihr könnt das Team von Facts & Feelings über Whatsapp erreichen.Uns interessiert: Was beschäftigt euch? Habt ihr ein Thema, über das wir unbedingt in der Sendung und im Podcast sprechen sollen?Schickt uns eine Sprachnachricht oder schreibt uns per 0160-91360852 oder an factsundfeelings@deutschlandradio.de.Wichtig: Wenn ihr diese Nummer speichert und uns eine Nachricht schickt, akzeptiert ihr unsere Regeln zum Datenschutz und bei Whatsapp die Datenschutzrichtlinien von Whatsapp.

Registered dietitian Leyla Muedin discusses a Frontiers in Microbiology paper suggesting certain probiotics may help sequester heavy metals. The study, sponsored by the Italian company Probiotical and conducted with University of Ghent and University of Piedmont Orientale, researchers used in vitro testing and the SHIME gut simulator to assess Lactiplantibacillus plantarum, Lactobacillus crispatus, and Lactobacillus acidophilus against cadmium, lead, chromium, and mercury. L. plantarum and L. crispatus reduced metal bioavailability primarily in the simulated colonic phase, while L. acidophilus showed minimal detoxification; mercury was least reduced (~10%). An ex vivo mouse-intestine system found probiotic pre-incubation of metals preserved epithelial integrity and reduced inflammatory responses. Leyla notes limitations: corporate funding, only three strains tested, and no in vivo or human trials, though the findings support further animal and clinical research.

SEGMENTS | Gilded Age Hotels at Florida's Mineral Springs | Tampa Shipyard Workers in World War I | The Redevelopment of Baldwin Park in Orlando

In this episode, we are joined by Dr. Paul Kaplan, economist, CFA charterholder, former Director of Research at Morningstar Canada, and co-author of Lifetime Financial Advice, for a fascinating exploration of life cycle finance. Drawing on decades of research in economics, portfolio construction, and asset allocation, Paul explains how financial planning should be grounded in optimizing lifetime consumption rather than relying on disconnected rules of thumb.   We explore how life cycle finance integrates consumption, saving, investing, and retirement spending into a single framework, why risk tolerance and risk capacity are fundamentally different concepts, and how human capital should be treated as part of an investor's balance sheet. Paul also walks through the life cycle model he and Tom Idzorek developed, explains why traditional retirement rules like the 4% rule lack theoretical foundations, and demonstrates an open-source spreadsheet that allows anyone to experiment with the model for themselves. This conversation brings together economics, portfolio theory, and financial planning into a practical framework for making better lifetime financial decisions.   Key Points From This Episode: (0:04) Introduction to Dr. Paul Kaplan and the topic of life cycle finance. (4:38) What life cycle finance is and why consumption smoothing is its central objective. (5:20) How life cycle models optimize saving, investing, retirement spending, insurance, and annuities. (6:36) Linking life cycle finance with Harry Markowitz's mean-variance optimization. (8:38) Why consumption—not wealth accumulation—is the true focus of financial planning. (9:56) The concept of an economic balance sheet: financial assets, human capital, liabilities, and net worth. (10:59) Holistic investor profiling beyond traditional risk tolerance questionnaires. (13:23) Why risk tolerance and risk capacity should never be combined into a single score. (16:48) Assessing the risk characteristics of human capital. (17:36) Applying utility theory behind the scenes in financial planning software. (19:15) Sample profiling questions that measure lifetime consumption preferences. (20:54) Why maximizing lifetime utility ultimately means optimizing consumption. (22:55) How preferences, needs, and circumstances shape lifetime financial plans. (24:13) The primary outputs of a life cycle model: consumption and asset allocation. (25:01) The roles of life insurance and annuities in lifetime financial planning. (27:44) How uncertain investment returns influence both spending and asset allocation. (28:19) Why longevity assumptions are critical in retirement planning. (29:37) Simplifying complex life cycle optimization into practical formulas. (30:27) Why life cycle finance challenges rules of thumb like the 4% withdrawal rule. (31:12) Flexible retirement spending versus fixed withdrawal strategies. (34:01) Why consumption should be treated as an output rather than an input. (36:05) The importance of asset location and after-tax portfolio construction. (37:04) Why asset allocation and asset location should be solved simultaneously. (38:19) Harry Markowitz on why asset allocation became the foundation of modern investing. (40:06) The need for financial planning software built on life cycle theory. (41:55) A walkthrough of Paul's open-source life cycle finance spreadsheet. (46:58) Understanding economic balance sheets and asset mix visualizations. (49:17) Which investor characteristics have the greatest influence on optimal asset allocation. (50:52) Why Nobel Prize-winning life cycle finance research has yet to become mainstream practice. (51:37) The evolving role of financial advisors in helping clients make rational financial decisions. (52:50) How Paul's own investment philosophy emphasizes indexing and asset allocation. (54:13) Factor investing, popularity theory, and connecting behavioral finance with asset pricing. (56:42) Paul's definition of success: applying first principles with rigor and integrity throughout his career. Links From Today's Episode: Meet with PWL Capital: https://calendly.com/d/3vm-t2j-h3p Rational Reminder on iTunes — https://itunes.apple.com/ca/podcast/the-rational-reminder-podcast/id1426530582. Rational Reminder on Instagram — https://www.instagram.com/rationalreminder/ Rational Reminder on YouTube — https://www.youtube.com/channel/ Benjamin Felix — https://pwlcapital.com/our-team/ Benjamin on X — https://x.com/benjaminwfelix Benjamin on LinkedIn — https://www.linkedin.com/in/benjaminwfelix/ Dr. Paul Kaplan: https://www.paulkaplan.com/  Lifetime Financial Advice (CFA Institute Research Foundation): Lifetime Financial Advice| Research Foundation  Life Cycle Finance Spreadsheet (Paul Kaplan's website): https://www.paulkaplan.com/lifetime-financial-advice  *Disclosure: Links to third-party materials are provided for your convenience and do not constitute an endorsement or recommendation of the products or services offered therein. Frontiers of Modern Asset Allocation (Wiley): https://www.wiley.com/en-us/Frontiers+of+Modern+Asset+Allocation-p-9781118029689  Popularity: A Bridge Between Classical and Behavioral Finance (CFA Institute Research Foundation): https://rpc.cfainstitute.org/research/foundation/2021/popularity-a-bridge-between-classical-and-behavioral-finance   Editing and post-production work for this episode was provided by The Podcast Consultant (https://thepodcastconsultant.com)  

What if the biggest risk factor for cancer, heart disease, and dementia isn't your genes, diet, or blood pressure but aging itself? Listen in as biogerontologist Dr. Matt Kaeberlein reveals how understanding the biology of aging could add not just years to our lives, but healthy decades, and why your dog might hold some of the most important clues.   In this episode, Therese Markow and Dr. Matt Kaeberlein discuss aging research. He explains that aging is characterized by damage accumulation and loss of resilience, leading to functional decline. Matt highlights the hallmarks of aging, such as deregulation of nutrient sensing and DNA damage, and the potential of interventions like rapamycin to slow aging. He notes that biological age is a significant risk factor for major diseases, and that understanding and addressing aging biology could significantly extend human lifespan. They also discuss the Dog Aging Project, with 55,000 participating dogs, which aims to uncover genetic and environmental factors influencing health and longevity in pets.    Key Takeaways: Our bodies are constantly being exposed to stress, and stress can move us out of the optimal zone of function. When we're young, we're very resilient and able to come back to optimal function. As we get older, we lose that resilience. When we slow aging in laboratory animals, we prevent the onset and progression of all of the major age-related functional declines and diseases simultaneously, because we've slowed biological aging. Based on what's possible in mice, it is estimated that we could potentially gain 2-3 additional decades of life if we can achieve this in humans. There is a genetic component to longevity; however, how big that genetic component is to longevity is hotly debated. The environment is also a large contributor.    "Biological age is the single greatest risk factor for nine of the top 10 killers in the United States, and it's not a small effect. The magnitude of effect from biological aging dwarfs all of the other risk factors combined…it's useful to appreciate how important biological age is to the risk of developing many of the chronic diseases and functional declines that limit quality and quantity of life for most people." —  Dr. Matt Kaeberlein   Episode References:  Dog Aging Project: https://dogagingproject.org/  Dog Aging Institute: https://dogaginginstitute.org/  Longevity for Dogs: https://www.youtube.com/@LongevityForDogs    Connect with Dr. Matt Kaeberlein: Professional Bio: https://halo.dlmp.uw.edu/people/matt-kaeberlein/  Publications: https://pubmed.ncbi.nlm.nih.gov/?term=%22kaeberlein+m%22[author]    YouTube: https://www.youtube.com/@mkaeberlein  LinkedIn: https://www.linkedin.com/in/mkaeberlein/    Connect with Therese: Website:  www.criticallyspeaking.net Bluesky: @CriticallySpeaking.bsky.social Instagram: @criticallyspeakingpodcast Email: theresemarkow@criticallyspeaking.net   Audio production by Turnkey Podcast Productions. You're the expert. Your podcast will prove it. 

If you shop at Aldi regularly or have been thinking about adding it to your grocery rotation, this episode is going to save you time and money. Leanne and Susie share their personal Aldi favourites, the specific products they recommend to clients, and the ones that look good but do not stack up. And if you have ever used AI to get nutrition advice, track your intake, or build a meal plan, there is a study published earlier this year that you genuinely need to hear about. In this episode: The Aldi products Leanne and Susie actually buy and recommend, across fresh produce, protein, dairy, snacks, frozen meals, and a few honest indulgences. Specific product names included, no vague recommendations Why the leafy greens at Aldi outperform the major supermarkets for freshness and shelf life, and how to store them to make them last even longer The Aldi protein yogurt, low-carb protein bread, beetroot hummus, tuna bean cups, and almond butter that both dietitians put on their regular shopping list and why A new study from March this year published in Frontiers in Nutrition comparing AI-generated diet plans against dietitian-designed plans: AI underestimated calories by up to 600, protein by 20 grams, and carbohydrates by 100 grams. Not a small margin of error, a significant one Why the false confidence AI creates around calorie and nutrient counts is the real danger, and the specific situations where Leanne and Susie would and would not use it in a nutrition context The Mission Carb Balance wrap reviewed: 16 grams of fibre and four grams of carbohydrate per wrap, a five-star health rating, and Leanne's strong views on why this product is not what it appears to be Why ultra-processed, low-carb wraps with modified wheat starch, wheat gluten isolate, and 16 grams of added fibre are a problem for most women's digestive health, and what to eat instead The creatine and heat question answered properly: can you add creatine to porridge, baked oats, or warm drinks without losing its effectiveness? What temperatures and time frames matter, and the one mistake Leanne sees clients make all the time with their creatine drink bottle See omnystudio.com/listener for privacy information.

It's two o'clock on a July afternoon. You walk out to check the garden, and your squash leaves are drooping so low they're nearly touching the mulch. Your tomato plants look like they've given up on the whole season. If your first thought, every single time, is “I need to water right now,” hold on a second before you grab that hose. Because that dramatic afternoon collapse you're looking at likely has absolutely nothing to do with how much water is in your soil. So today on Just Grow Something we're covering three things: what's actually happening inside a plant's cells when the temperature spikes, the specific ways to tell heat stress wilting apart from drought stress wilting, and what heat stress does beyond the leaves, because your tomatoes and peppers and squash can look perfectly fine and still be failing to set fruit, and that's a heat problem too. Let's dig in. Join the Fall Garden Challenge: https://justgrowsomethingpodcast.com/fall References and Resources: Graci, S., & Barone, A. (2024). Tomato plant response to heat stress: a focus on candidate genes for yield-related traits. Frontiers in Plant Science, 14, 1245661. https://doi.org/10.3389/fpls.2023.1245661 Sellami, D., & Kooli, S. (2025). Physiological and growth responses of tomato plants to heat stress. Discover Plants. https://doi.org/10.1007/s44372-025-00462-3 University of Maryland Extension — Drought and Excessive Heat Stress  https://extension.umd.edu/resource/drought-and-excessive-heat-stress University of Maryland Extension — Pollination of Vegetable Crops in a Changing Climate https://extension.umd.edu/resource/pollination-vegetable-crops-changing-climate NC State Cooperative Extension, Beaufort County — What "Wilting" Really Means: Heat Stress vs. Water Needs https://beaufort.ces.ncsu.edu/news/what-wilting-really-means-heat-stress-vs-water-needs/ Oregon State University Extension — Heat Wave in the Garden: How to Identify and Prevent Heat Stress in Plants https://extension.oregonstate.edu/catalog/em-9556-heat-wave-garden-how-identify-prevent-heat-stress-plants Oregon State University Extension — Why Vegetables Drop Blossoms https://extension.oregonstate.edu/news/why-vegetables-drop-blossoms Oregon State University Extension — Mother Nature May Need Help to Pollinate Squash and Cucumbers https://extension.oregonstate.edu/news/mother-nature-may-need-help-pollinate-squash-cucumbers Just Grow Something: https://justgrowsomething.com Gardening Courses: https://justgrowsomething.com/courses Just Grow Something Merch and Downloads: https://justgrowsomething.com/shop Just Grow Something Gardening Friends Facebook Group: https://www.facebook.com/share/g/18YgHveF5P/ Check out how you can become a patron on Patreon: https://www.patreon.com/JustGrowSomething Feed my coffee habit: https://buymeacoffee.com/justgrowsomething Amazon storefront: https://www.amazon.com/shop/justgrowsomething Get 10% off and FREE shipping on my favorite raised planters at Planter Box Direct using code JUSTGROW10: https://planterboxdirect.com/?ref=593 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

What if a single nerve in your ear could shift you out of fight-or-flight in 10 minutes? Jane Ollis explains why your vagus nerve and HRV may be the most overlooked levers for stress, sleep, and longevity. In this episode of Health Longevity Secrets, Robert Lufkin MD sits down with Jane Ollis — founder and CEO of Sona, medical biochemist with a career across NASA, Oxford, and the NHS — to unpack the science of the vagus nerve, heart rate variability (HRV), and the autonomic nervous system. Jane breaks down why HRV is one of the strongest predictors of all-cause mortality, why a tiny patch of "fish gill pipework" in your outer ear is the key to calm, and how Sona's AI-powered closed-loop vagus nerve stimulator personalizes a 10-minute daily protocol to retrain a nervous system stuck in chronic sympathetic overdrive. CHAPTERS: 00:00 — Introduction 01:01 — Meet Jane Ollis: From NASA and Oxford to Vagus Nerve Science 03:05 — Why Chronic Stress Drives Inflammation, Insulin Resistance and Disease 05:07 — Sympathetic vs Parasympathetic: The Two Arms of Your Autonomic Nervous System 08:09 — The Hidden Benefit of Stress (And Why You Still Need Recovery) 11:13 — Cortisol, Adrenaline and How the Stress Response Actually Works 12:14 — Acetylcholine, Repair Mode and the Parasympathetic Switch 14:19 — Symptoms of Autonomic Imbalance and Sympathetic Overdrive 17:22 — Heart Rate Variability: Why It Predicts All-Cause Mortality 20:27 — HRV, Aging, Blood Pressure and the Baroreceptor Connection 23:29 — Anatomy of the Vagus Nerve: The Body's Communication Superhighway 26:33 — Free Vagus Nerve Hacks: Slow Breathing, Humming and Chanting 28:35 — How Vagus Nerve Stimulation Works (Cervical vs Auricular Branch) 30:37 — From Epilepsy to Depression: 30 Years of Implanted VNS Research 32:40 — Inside Sona: The First AI-Powered Closed-Loop Vagus Nerve Stimulator 35:44 — How to Use Sona: 10-Minute Daily Sleep Ritual and Neuroplasticity Stack 38:46 — Sleep Quality, Deep Sleep and Stroke Rehab: What the VNS Evidence Shows 40:49 — The Future: Personalized VNS for Anxiety, PTSD, Long COVID and Metabolic Disease 42:52 — The Biggest Myth About Stress, Recovery and Resilience 45:00 — Final Takeaway: One Small Action to Calm Your Nervous System Today KEY TAKEAWAYS: Higher heart rate variability (HRV) is one of the strongest non-invasive predictors of all-cause and cardiovascular mortality. The parasympathetic nervous system isn't about "switching off" — it switches on repair, digestion, and immune housekeeping via acetylcholine. 80% of vagus nerve fibers carry information from the body to the brain — it's a communication highway, not just an output. The auricular branch of the vagus nerve in the outer ear (cymba conchae) is a 100% afferent vagal pathway. Slow-paced breathing with a long nasal exhale, humming, and chanting are zero-cost vagal activation tools that raise HRV. Closed-loop, AI-personalized vagal stimulation may unlock applications in anxiety, depression, PTSD, long COVID, and metabolic disease. STUDIES & SOURCES: Sammito et al., 2022 — HRV as a predictor of all-cause mortality: https://pubmed.ncbi.nlm.nih.gov/36243195/ Wang et al., 2023 — taVNS in depression meta-analysis: https://pubmed.ncbi.nlm.nih.gov/37230264/ Wu et al., 2018 — taVNS for depression: Frontiers in Psychiatry taVNS for insomnia (PSQI): ⭐ Enjoying the show? Please leave a 5-star review on Apple Podcasts — it takes 30 seconds and helps more people discover the science of health and longevity. Thank you!New episodes every other Tuesday. Subscribe so you don't miss one.Continue this conversation on Substack: https://robertlufkinmd.substack.comLies I Taught In Medical School — Free sample chapter: https://www.robertlufkinmd.com/lies/Web: https://www.robertlufkinmd.comYouTube: https://www.youtube.com/robertlufkinmdX: https://x.com/robertlufkinmdInstagram: https://www.instagram.com/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinLinkedIn: https://www.linkedin.com/in/robertlufkinmd/

Weniger als vier von 100. So wenige gingen ein Jahr später noch ins Fitnessstudio. Und das lag nicht daran, dass sie nicht wollten.Fitness-Gewohnheiten – ob gesundes Essen, Supplement-Einnahme oder regelmäßiges Training – spielen neurobiologisch in einer eigenen Liga. Am Anfang arbeitet Dein Gehirn gegen Dich. Am Ende dieser Folge weißt Du, warum, und mit welchen drei Strategien Du trotzdem dranbleibst.Du erfährst:Warum sich die ersten Wochen wie ein Kampf anfühlen, und wann sich das drehtWarum die „21-Tage-Regel“ nicht funktioniert – und wie lange Du wirklich brauchst3 simple Strategien, die in Studien zu >50% häufigerem Training führen.Los geht's. Und dann: dranbleiben.____________*WERBUNG: Infos zum Werbepartner dieser Folge und allen weiteren Werbepartnern findest Du hier.

This episode's a bit schizophrenic!  Firstly, we look at Kate Bush, whose first single “Wuthering Heights” was released against the wishes of her record company – too long and too weird, they said.  We all know how wrong they were, don't we? Our Album You Must Hear Before You Die is "Junkyard" by The Birthday Party, a band who embodied chaotic, confrontational music.  This is as far as you can get from Kate Bush! As you can guess, Mick loves them! Knockin' on Heaven's Door looks at Mike Vernon, Denis Locorriere (of Dr Hook fame), and members of Blood, Sweat & Tears, and Motorhead.   Enjoy!  References:  Kate Bush, Dennis Locorriere, Dr. Hook & the Medicine Show, "Sylvia's Mother", “The Cover of 'Rolling Stone', Ray Sawyer, Shel Silverstein, abortion, Mike Vernon, David Bowie, John Mayall's Bluesbreakers (featuring Eric Clapton), Fleetwood Mac, “Albatross”, Bo Diddley, Storyteller.  The Complete anthology 1964-1990, Rod Stewart, David Clayton-Thomas, Carl Georg Viktor "Jojje" Wadenius, Phil Campbell, Lemmy, Hawkwind, Robert Dimery, The Birthday Party, Junkyard, Tony Cohen, Nick Launay, Ed "Big Daddy" Roth, Rat Fink, Nick Cave, Bad Seeds, “The Firstborn is Dead”, “Tupelo”, “From Her to Eternity”, “Mutiny in Heaven”, Caulfield Grammar School, Mick Harvey, Phill Calvert, Rowland S. Howard, "Big-Jesus-Trash-Can", "She's Hit", "6" Gold Blade", Tracy Pew, Midnight Oil, “Half Deaf and Completely Mad”, Tony Cohen, David Gilmour, EMI, Ricky Hopper, "The Kick Inside”, KT Bush Band, Andrew Powell, Emily Brontë, Lindsay Kemp, Lionheart, Stuart Elliott, Cockney Rebel, Fear of Flying, Before the Dawn, “Kite”, “The Man with the Child in his Eyes”, “James and the Cold Gun”, "Wuthering Heights", “Bohemian Rhapsody”, Pink Floyd, “Wish You Were Here”, Hounds of Love, "Running Up That Hill", "Cloudbusting", Stranger Things, Aerial, "Bertie", 50 Words for Snow, Peter Gabriel, “Games without Frontiers”, “Don't Give Up”   Playlist - All the music and artists we talked about in this episode Kate Bush Interview  Kate Bush Intro - 1978 Kate Bush with David Gilmour  Send us a message, so we know what you're thinking!

Over a few generations starting in the mid-1800s, millions of Scandinavians left their homes to seek new lives across the Atlantic. Why did they do it? Where did they go? And what did the people who stayed behind think about it all?

Send us a text if you want to be on the Podcast & explain why!Dan Garner - Vitality Blueprint co-founder review on swearing FB post July 3rd 2026.One word can change your output, and the data is wild. We're talking about swearing and physical performance, sparked by a 2024 mini review in Frontiers in Psychology that pulls together controlled studies on what happens when you repeat a swear word during a max-effort attempt versus a neutral word. Same task, same setup, different word, and the “explicit” option starts to look like a legitimate training variable.We walk through the headline results and why they matter for real-world coaching: wall sits held longer, more push-ups to failure, longer planks, stronger grip strength, and even a bump in Wingate test peak and average power. We also zoom out for perspective on how big those percentage changes are compared to typical training gains, and why replication makes this more than a one-off gimmick.Then we get practical and a little uncomfortable in the best way: why the mechanism is still unclear, why you shouldn't assume it transfers to long endurance efforts, and how to apply it ethically as a coach. We talk mirroring clients, setting expectations, respecting your environment in busy gyms, and the fine line between “authentic” and “unprofessional,” especially when one offended person can cost you a review, a referral, or a room full of trust.If you like evidence-based training with real-life coaching judgment, hit subscribe, share this with a trainer friend, and leave a quick rating and review.Want to become a SUCCESSFUL personal trainer? SUF-CPT is the FASTEST growing personal training certification in the world!Want to ask us a question?  Email info@showupfitness.com with the subject line PODCAST QUESTION to get your question answered live on the show!Website: https://www.showupfitness.com/Become a Successful Personal Trainer Book Vol. 2 (Amazon): https://a.co/d/1aoRnqANASM / ACE / ISSA study guide: https://www.showupfitness.com

SEGMENTS | Florida Freedom Tour Mobile Museum | Women in British Colonial Florida | New Smyrna in British Florida

Hello Interactors,Welcome to summer where Interplace turns its attention to physical geography and the environment. It's already a crazy El Niño — thanks in large part to global warming — and the United States is having a big birthday. How might these be related and what to do about it?What follows is not a celebration or a condemnation, but more of a reckoning. I look at what was built, what was deliberately forgotten, and what is now continually arriving, season by season, in forms of weather the founders could not have imagined.Although Alexander Humboldt — one of the world's most famous scientists at the time — did warn Jefferson of the effects of human-induced climate change in 1804. He based his prediction on changes he observed in forests and water systems as a result of mono-crops and industrial “steam and gas”. Jefferson ignored him.BUILDING, BURNING, BILLOWING BACKOn this momentous 250th Fourth of July, when the world is experiencing record level extreme weather events, let's reflect on how over the last 250 years the United States helped build, extract, and then burn the material and political conditions that made climate change possible. From the beginning, it tied itself to land, extraction, mobility, and expansion. Over time those commitments became an energy system built on coal, oil, gas, highways, suburbs, industrial agriculture, and a development model that treated nature as an inexhaustible storehouse. That legacy is now legible in the atmosphere itself. Let's light a Roman Candle in celebration!Even before the 4th of July fireworks celebrations create another nationwide 42% average increase in fine particulate matter (Seidel, et al., 2015), the United States bears the single largest share of cumulative historical CO₂ emissions of any nation . We represent roughly 20 percent of the global total since 1850 contributing approximately 0.2°C of warming to date (Carbon Brief, 2021; UNEP, 2023). To represent four percent of the world's current population and be responsible for nearly a fifth of its cumulative warming is not a coincidence of geography or fake news. It is the outcome of deliberate choices about how a republic would be organized, energized, and expanded across two and a half centuries.The United States has long imagined freedom in spatial terms: movement, property, settlement, mastery, frontier, and circulation. Those abstract ideals were made real through land theft and remade landscapes, as well as through infrastructure built in significant part by African and African American enslaved labor. Each step along the way depended on ever-greater throughput of energy, labor, and material. In that sense, the country's history is also a history of how thought became organized around extraction and exploitation, until those thoughts and actions themselves became a kind of common sense. But by the late nineteenth century and early twentieth centuries increased industrialization meant emissions grew. They surged during the postwar era and peaked in the early 2000s — a trajectory that maps almost exactly onto the spatial project of suburban expansion, highway construction, and fossil-fuel-dependent agriculture (Climate Change Tracker, 2024). Two-thirds of the country's cumulative warming impact derives from fossil CO₂ alone. The built environment of American freedom is as inseparable from the chemical footprint it left behind as a firecracker's scattered debris and carbon residue.This leaves us with a climate crisis that is not just the result of a few bad policy choices in the late twentieth century. We exist in a cumulative outcome of a long national project that normalized combustion as prosperity and treated atmospheric consequence as some distant abstraction. Kind of like turning up the radio to drowned out the sound of your car making a funny noise. The federal state government played a central role in this process. Not only through direct policy and subsidies, but through the development of roads, ports, power systems, agricultural regimes, and military logistics that expanded the scale of fossil dependence at every scale of national life.The fossil fuel industry understood this trajectory earlier than the public was permitted to know. A systematic analysis published in Science found that ExxonMobil's own scientists accurately projected and skillfully modeled global warming due to fossil fuel burning from as early as 1977. These projections are consistent with subsequent observations. And yet, for decades, the company publicly pushed doubt and denial (Supran, Rahmstorf, & Oreskes, 2023). Consequently, what America projects as “economic growth”, fueled enormously by the fossil fuel industry, is embedded not only in a collective national memory but in the scientific record.The irony is that America's confidence in its own permanence rested on a false sense of geography. The landscape seemed stable because the costs were displaced in the form of upstream mining, downstream pollution, hidden emissions, imported and exported harm, and deferred climate effects. The effects on the atmosphere made that displacement impossible to sustain. The ‘progress' that had been scattered across space and time returns as heat, drought, fire, flood, and increasingly volatile weather. We built a world in which the rewards of extraction were immediate while the penalties were delayed. Call it what you will — the climate crisis is just the debt of delay, dressed as disaster.KNOWING, NEGLECTING, NEUTERING KNOWLEDGEThe USA did not simply keep burning and expanding on autopilot. By the late twentieth century, it had also begun to lose the institutional capacity to understand what its own trajectory meant. The problem was no longer that the 1970's scientific picture Exxon had already portrayed was absent. The evidence was clear. By the early 1990s the United States had ratified the United Nations Framework Convention on Climate Change (UNFCCC) and formally accepted the goal of returning greenhouse-gas emissions to 1990 levels by the end of the decade.The barrier to progress was not ignorance, but a degraded relationship between knowledge and power. This was engineered in part by more fossil fuel industry campaigns to sow doubt about science it privately accepted. Historians of science Naomi Oreskes and Erik Conway documented how a loose-knit network of industry-connected scientists ran effective campaigns to mislead the public on issues from tobacco to climate change. They exploited the media's tendency toward false balance and keeping controversy alive long after scientific consensus had been reached (Oreskes & Conway, 2010). The strategy was to make certainty seem uncertain, and it worked. For decades, political inaction persisted through every window of action that may have helped.By the mid-1990s, climate change had become legible enough for federal institutions to name, study, and plan around, but the machinery of governance was being bent in the opposite direction. Newt Gingrich and the Republicans who rose with him may not have invented anti-government politics, but they weaponized it. Curiously, through pro-governmental politics. While their rhetoric promised efficiency and modernization, in practice it often meant cutting staffs, weakening committees, abolishing subcommittees, and treating the legislature less as a site of deliberation than as a theater of permanent combat. After all, their own staffers affectionately referred to Gingrich and his wrecking crew as ‘jihadists' — even as those same politicians promulgated and attached that term as a slur toward Muslims. One of the most consequential acts of this period was the 1995 defunding of the Office of Technology Assessment. This was a bipartisan, independent body that had produced over 750 reports on complex scientific and technical questions since 1974, including major studies on energy policy, environmental risk, and the long-range consequences of atmospheric change. Gingrich had vowed to kill the OTA during his 1994 election campaign. He kept his promise, and with it eliminated one of Congress's primary mechanisms for converting scientific knowledge into durable legislative capacity (Wikipedia, Office of Technology Assessment; AAAS Science, 2019).A legislature cannot respond intelligently to a long-range atmospheric crisis if it has stripped away the very mechanisms designed to synthesize evidence, test assumptions, and tackle complex questions over time. What replaced deliberations mediated by experts was a vacuum quickly filled by industry lobbyists — the same industry that, amongst themselves, knew exactly what Gingrich was doing. Research on institutional dynamics in climate governance consistently finds that fragmented policy, weak intergovernmental coordination, and the erosion of technical capacity are among the most significant barriers to effective long-range climate action (Jaisridhar et al., 2025; Birchall, Bonnett, & Kehler, 2023).The thinning of Congress's own cognitive infrastructure in 1995 was a bureaucratic adjustment that disabled the country's capacity to govern on topics beyond the timescales and dimensions of a single administration. The political system was becoming less capable of converting recognition into sustained action precisely as the need for that conversion became most urgent. The United States not only helped create the conditions for warming but undermined its own capacity to govern the effects warming created. The atmosphere was warming and so was the willful weakening of the world's most powerful potential partner in planetary protection.CASCADES, CRISES, AND COMING TO TERMSWhat follows is not simply a warmer world, but a less legible and actionable one. Once a political system weakens its own capacity to think long-term, it becomes ill-equipped to face a future that arrives not as a single rupture but as a cascade of self-reinforcing disruptions. We've all experienced or read about hotter summers, fire, more erratic rainfall, stressed coasts, shifting storm tracks, and weather that no longer behaves as the old seasonal calendar once did. Anthropogenic warming is already increasing variability in frequency and severity of weather systems. This in turn can alter local precipitation variability, storm behavior, and the climatic conditions on which seasonal expectations have long depended (Robinson, 2021; Wang et al., 2017; Scher & Messori, 2019). In several regions, climate change is expected not only to shift average conditions but to change seasonal predictability itself — especially for rainfall — making the future harder to read through the calendars and risk assumptions modeled and built from the past (Le et al., 2023; Delsole et al., 2014).Even now, the atmosphere offers a live demonstration of this instability. On June 11, 2026, NOAA officially declared that El Niño has arrived — with a 63 percent probability of reaching “very strong” intensity, defined as sea surface temperature anomalies of at least +2°C in the equatorial Pacific. This would rank it among the largest events in the historical record (NOAA, 2026). What makes 2026 categorically different from prior super events is not just its projected intensity but its baseline. This El Niño begins from the warmest ocean temperatures in human history, layered onto anthropogenic warming that has already pushed the planet to 1.55°C above preindustrial levels.As one paper argued in April, the El Niño is the accelerant; the fuel was already stacked (Hansen et al., 2026). The World Meteorological Organization (WMO) has placed an 86 percent probability on at least one year between 2026 and 2030 surpassing 2024 as the warmest on record, with 2027 — when El Niño's thermal lag typically produces its most extreme global signals — as the most likely candidate (WMO, 2026).When that variability is layered onto long-term warming, the result is not just discomfort but a deeper erosion of climatic predictability. ENSO — the El Niño-Southern Oscillation, the coupled ocean-atmosphere system that drives El Niño's periodic warming and its counterpart La Niña's cooling across the tropical Pacific — is not a new phenomenon, but its behavior is changing. Model evidence indicates that ENSO-related rainfall variability is likely to intensify and shift eastward under greenhouse warming, creating more severe and sometimes novel climate conditions across the terrestrial tropics (Cai et al., 2021; Rifai, Li, & Malhi, 2019). The question is no longer whether the climate will change, but how many of the social and political structures built on climatic regularity can survive that change.Climate change is often presented as a technical or environmental problem to be solved. Especially amidst a culture of pervasive techno-optimism. But climate change is way more fundamental than this. It's a reordering of the relationship between how we need to think and the geography in which we exist. This includes political geography and a reordering of political imagination as it relates to physical geography. The old originally envisioned republic of the USA assumed that land could be mastered, seasons could be predicted, and institutions could absorb shock without losing coherence. Those assumptions no longer hold.The old assumption that infrastructure could be planned around stationary baselines is increasingly at odds with the evidence. We can already see how energy systems show measurable vulnerability to climatic uncertainty and extremes. Modeled systems evidence declines in reliability and large performance gaps when future weather variation is not adequately incorporated into planning (Perera et al., 2020; Ouyang et al., 2023).As a result, the challenge ahead is not adaptation to these changes in the narrow sense, but reconstruction of our relationship to them in the broad sense. This may seem impossible in today's American political system, but truly Democratic societies will need stronger scientific institutions, more durable legislative capacity, and trustworthy public agencies able to interpret risk before disaster becomes routine. They will need not only infrastructure, but intelligence. Embodied intelligence — embodied engagement with physical and social environments rather than as a purely singular-brain augmented by LLM computation. This includes a renewed ability to gather, preserve, and act on knowledge over long horizons.The literature on adaptation governance is clear that resilience depends on organizational learning, intergovernmental collaboration, inclusive planning, and long-term institutional capacity. Short-term, reactive, market or donor-driven interventions that respond to emergencies without building the durable frameworks that prevent them won't work (Birchall et al., 2026; Rahman & Islam, 2024). What this means practically is the reconstitution of the kind of congressional expertise that was dismantled in 1995. We need not merely revive the OTA but to imagine a broader democratic intelligence infrastructure capable of thinking on the timescales that climate change demands — decades, generations, and centuries. Without that, climate change will continue to be experienced as a succession of emergency, political, or market conditions rather than as a governable transformation.We can do this. After all, a country that once imagined itself through movement, expansion, and mastery made a certain kind of freedom seem natural. A new kind of freedom can be made to seem natural too. But right now our current system returns prosperity for many — but heat, flood, instability, and constraint for all. What was built now must be lived within — good and bad — while what was extracted must now live in the atmosphere — all bad. What gets burned today, will burn more later. The political order that was built through extraction, combustion, and territorial expansion must confront the atmospheric and hydrological consequences of those choices.That confrontation will only intensify. Past century's cumulative emissions have already committed the planet to changes that will outlast any government, living generation, or institution that exists. Including you and me. The next 250 years will belong less to societies that imagine escape than to those that can build the institutional intelligence, infrastructural redundancy, and long-term public capacity required to inhabit a less legible and hospitable climate (Ouyang et al., 2023; Jaisridhar et al., 2025).So, as you watch the rocket's red glare and bombs bursting in air — sending even more smoke, chemicals and debris everywhere — know the flag will still be there. But to endure, it must repair an institution to be once again knowledgeable and fair.ReferencesBirchall, S. J., Villeneuve, K., Rose, D., Baran, N. N., & Adams, S. (2026). Exploring the modifying effects of adaptive capacity on resilience to climate change across 4 coastal cities in British Columbia, Canada. Cities.Birchall, S. J., Bonnett, N. L., & Kehler, S. (2023). The influence of governance structure on local resilience: Enabling and constraining factors for climate change adaptation in practice. Urban Climate.Cai, W., McPhaden, M., Grimm, A., Rodrigues, R., Taschetto, A., Garreaud, R., … Vera, C. (2020). Climate impacts of the El Niño–Southern Oscillation on South America. Nature Reviews Earth & Environment.Cai, W., Santoso, A., Collins, M., Dewitte, B., Karamperidou, C., Kug, J., … Zhong, W. (2021). Changing El Niño–Southern Oscillation in a warming climate. Nature Reviews Earth & Environment.Carbon Brief. (2021). Analysis: Which countries are historically responsible for climate change?Climate Change Tracker. (2024). United States of America: Historic contribution to global warming since 1850.Delsole, T., Yan, X., Dirmeyer, P., Fennessy, M., & Altshuler, E. (2014). Changes in seasonal predictability due to global warming. Journal of Climate.Holgate, C., Evans, J., Taschetto, A., Gupta, S. A., & Santoso, A. (2022). The impact of interacting climate modes on east Australian precipitation moisture sources. Journal of Climate.Jaisridhar, P., Nirosha, R., Jasimudeen, S., Senthilkumar, M., Ponsneka, I., & Raja, P. (2025). Institutional dynamics in climate change adaptation: A bibliometric analysis. Frontiers in Environmental Science.Le, P., Randerson, J., Willett, R., Wright, S., Smyth, P., Guilloteau, C., Mamalakis, A., & Foufoula-Georgiou, E. (2023). Climate-driven changes in the predictability of seasonal precipitation. Nature Communications.Oreskes, N., & Conway, E. M. (2010). Merchants of Doubt: How a Handful of Scientists Obscured the Truth on Issues from Tobacco Smoke to Global Warming. Bloomsbury Press.Ouyang, H., Tang, X., Zhang, R., Baklanov, A., Brasseur, G., Kumar, R., Han, Q., & Luo, Y. (2023). Resilience building and collaborative governance for climate change adaptation in response to a new state of more frequent and intense extreme weather events. International Journal of Disaster Risk Science.Perera, A., Nik, V., Chen, D., Scartezzini, J., & Hong, T. (2020). Quantifying the impacts of climate change and extreme climate events on energy systems.Rahman, M. M., & Islam, M. S. (2024). Institutional dynamics and climate adaptation: Unveiling the challenges and opportunities in coastal Bangladesh.Rifai, S., Li, S., & Malhi, Y. (2019). Coupling of El Niño events and long-term warming leads to pervasive climate extremes in the terrestrial tropics.Robinson, W. (2021). Climate change and extreme weather: A review focusing on the continental United States.Scher, S., & Messori, G. (2019). How global warming changes the difficulty of synoptic weather forecasting.Supran, G., Rahmstorf, S., & Oreskes, N. (2023). Assessing ExxonMobil's global warming projections.UNEP. (2023). Current and historic contributions to global warming and emissions in the United States from 1850 to 2021. Statista.Wang, X., Jiang, D., & Lang, X. (2017). Future extreme climate changes linked to global warming intensity. Science Bulletin.Hansen, J., Kharecha, P., Morgan, D., & Vest, J. (2026, April 15). Super-Duper El Niño. Columbia University Earth Institute.National Oceanic and Atmospheric Administration. (2026, June 11). El Niño forms, expected to strengthen, say NOAA forecasters [Press release].NOAA Climate Prediction Center. (2026, June 11). ENSO diagnostic discussion. National Weather Service.Seidel, D. J., & Birnbaum, A. N. (2015). Effects of Independence Day fireworks on atmospheric concentrations of fine particulate matter in the United States. Atmospheric Environment.World Meteorological Organization. (2026). Global annual-to-decadal climate update 2026–2035. WMO. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit interplace.io

+++ Argumente einer KI kamen bei Probanden authentischer rüber als die von Menschen +++ Warum sich Delfine an Fischerboote hängen +++ Rechtshänder, Linkshänderin - es hat viel mit Übung zu tun +++ Mücken haben gerade optimale Bedingungen +++**********Weiterführende Quellen zu dieser Folge:KI-Experiment mit politischen Diskussionen, Plos One, 01.07.2026Studie zu Delfinen und Fischerbooten, Frontiers, 03.07.2026Studie zu dominanten Händen, PNAS, 30.06.2026Der Mückenatlas unter anderem vom Leibniz-Zentrum für Agrarlandschaftsforschung**********Ihr könnt uns auch auf diesen Kanälen folgen: TikTok und Instagram .

What if grief isn't something we're meant to "get over"—but something we're meant to carry with love? In one of his most personal episodes ever, Darin opens his heart following the passing of his mother, Sandra Lee Olien. Rather than offering easy answers or tidy stages of grief, he shares the raw, complicated reality of loss: the tears, the gratitude, the anger, the laughter, the memories, and the profound realization that death doesn't simply teach us about endings—it teaches us how to live. Drawing from psychology, cultural traditions around the world, personal stories, and the wisdom of those facing the end of life, Darin explores why Western culture struggles with grief, why love is an active practice rather than a feeling, and how embracing mortality can become one of the greatest invitations to authenticity, forgiveness, vulnerability, and purpose. This is not simply an episode about death. It's an episode about living so fully that, when the end eventually comes for all of us, there is as little left unsaid as possible.     What You'll Learn Why Western culture often avoids meaningful conversations about grief The difference between "moving on" and maintaining continuing bonds with loved ones How cultures around the world approach death and remembrance Why grief isn't linear—and why that's completely normal The psychology of disenfranchised grief Darin's deeply personal reflections after losing his mother How unconditional love creates lifelong resilience Why unresolved relationships become our greatest regrets The five most common regrets people share at the end of life Why vulnerability is one of the greatest expressions of love How death can become one of life's greatest teachers Practical ways to live with more honesty, forgiveness, and purpose     Chapters 00:00:00 – Welcome to SuperLife 00:00:33 – Sponsor: Alkemis Paint 00:03:24 – A deeply personal announcement: the loss of Darin's mother 00:04:01 – Why this is the first episode about grief 00:05:04 – Grief, celebration, and holding conflicting emotions at once 00:06:00 – Why life continues after loss 00:07:02 – Death teaches us how to love 00:08:11 – Why grief receives so little space in Western culture 00:09:14 – Understanding disenfranchised grief 00:10:24 – Moving on versus maintaining continuing bonds 00:11:25 – Why grief doesn't have a finish line 00:12:01 – Modern society has outsourced death 00:13:17 – Moving inward instead of moving on 00:13:33 – Sponsor: Manna Vitality 00:15:28 – How Mexico celebrates ongoing relationships with ancestors 00:16:16 – Madagascar, Ghana, India, and global grief traditions 00:18:15 – Why rituals help us process loss 00:19:30 – Allowing yourself to truly feel 00:20:27 – Remembering Sandra Lee Olien 00:21:36 – A mother's unconditional love 00:22:41 – How love creates courage and confidence 00:23:32 – Letting go while honoring another person's choices 00:24:26 – Celebrating kindness, resilience, and stubborn strength 00:25:25 – Feeling his mother's presence after her passing 00:26:17 – Love is an active practice 00:27:25 – Why nothing important should remain unsaid 00:28:20 – The five regrets of the dying 00:29:29 – Living your own life instead of someone else's expectations 00:30:10 – Work, vulnerability, friendship, and choosing happiness 00:31:24 – Death as the other side of SuperLife 00:31:54 – The greatest fatal convenience: assuming there's more time 00:32:57 – Responsibility, forgiveness, and radical honesty 00:33:29 – Grief and gratitude can exist together 00:34:22 – Say the thing. Forgive. Love now. 00:34:45 – A heartfelt farewell to Mom 00:34:53 – Closing thoughts     Thank You to Our Sponsors Alkemis: Go to https://alkemispaint.com/ and use code DARIN10 for 10% off your order. Manna Vitality: Go to mannavitality.com/ and use code DARIN12 for 12% off your order.     Join the SuperLife Patreon: This is where Darin now shares the deeper work: - weekly voice notes - ingredient trackers - wellness challenges - extended conversations - community accountability - sovereignty practices Join now for only $7.49/month at https://patreon.com/darinolien     Find More from Darin Olien: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Platform & Products: superlife.com New Show: Roadmap to Happiness     Key Takeaway "Death isn't the opposite of a SuperLife—it reveals whether we've truly lived one. The conversations we avoid, the forgiveness we postpone, the love we leave unspoken, and the dreams we delay all become painfully clear when we're reminded that none of us is promised more time. Grief isn't something to conquer or rush through. It's love continuing to exist after physical presence has ended. And perhaps the greatest tribute we can offer those we've lost is to live with more honesty, more courage, more vulnerability, and more love while we're still here."     Bibliography/Sources: Peer-Reviewed Research & Journals Phan, H. P., Ngu, B. H., Chen, S., & Hsu, L. (2025). How cultural beliefs and rituals may help alleviate grief and despair: A four-dimensional framework. Frontiers in Sociology, 10. https://doi.org/10.3389/fsoc.2025.1620016 Books & Academic Encyclopedias Doka, K. J., & Martin, T. (2002). Disenfranchised grief. Research Press. https://books.google.com/books?id=disenfranchised-grief SAGE Publications. (n.d.). Death rituals. In SAGE Encyclopedia of Anthropology. https://sk.sagepub.com/reference/anthropology Ware, B. (2011). The top five regrets of the dying: A life transformed by the dearly departing. Hay House. https://bronnieware.com/blog/regrets-of-the-dying/ Psychology & Cultural Publications Kuzo and Foulk Funeral Homes. (2024). Cultural traditions around death and mourning: A global perspective. https://www.kuzofoulkfh.com/ Simply Psychology. (2026). Grief across cultures: How different traditions approach loss and mourning. https://www.simplypsychology.org/

Welcome to Nerd Alert, a series of special episodes bridging the gap between marketing academia and practitioners. We're breaking down highly involved, complex research into plain language and takeaways any marketer can use.In this episode, Elena and Rob dig into a direct experiment comparing TV and YouTube advertising to find out which format drives more attention, stronger emotion, and better brand memory.Topics covered:•    [01:40] "TV versus YouTube"•    [02:00] How the study was designed•    [03:46] Which platform captures more attention?•    [05:56] The serial position effect and ad memory•    [06:36] Your body remembers ads your brain forgets•    [08:20] What this means for your media mixTo learn more, visit marketingarchitects.com/podcast or subscribe to our newsletter at marketingarchitects.com/newsletter.Resources: Weibel, D., di Francesco, R., Kopf, R., Fahrni, S., Brunner, A., Kronenberg, P., Lobmaier, J. S., Reber, T. P., Mast, F. W., & Wissmath, B. (2019). TV vs. YouTube: TV advertisements capture more visual attention, create more positive emotions and have a stronger impact on implicit long-term memory. Frontiers in Psychology, 10, 626. https://doi.org/10.3389/fpsyg.2019.00626Get more research-backed marketing strategies by subscribing to The Marketing Architects on Apple Podcasts, Spotify, or wherever you listen to podcasts.

Send us Fan MailWhat does AI literacy actually look like for pathologists, researchers, and future clinicians? And how do you teach it in a way that is practical, not abstract?In this episode, I talk with Candice Chu, DVM, PhD about something I think a lot of people in digital pathology and computational pathology are feeling right now: AI is moving fast, but education is still catching up.Candice is a clinical pathologist, veterinarian, and educator building AI-focused teaching and research at Texas A&M. We worked together before on digital pathology and image analysis projects, so this conversation felt especially grounded. We talk about her AI literacy curriculum framework for veterinary education, why she decided to build it, and what it takes to teach AI in a way that is useful, ethical, and realistic.This episode is about understanding what AI tools are good for, where they can waste your time, and why hands-on experience matters. Candice explains why she sees AI as a set of tools, not a belief system. Try them. Learn them. Keep what improves your workflow. Drop what does not.We also talk about the difference between putting educational content online and building formal institutional teaching. That matters because social media can move quickly, but curriculum changes, research, and professional organizations shape longer-term adoption. Candice shares how her course started as a low-stakes elective, then grew into a more structured framework that combines education with publishable research.A big part of this conversation is the curriculum itself. We go through what students actually learn: AI fundamentals without heavy math, machine learning and image analysis, large language models, prompt engineering, chatbot building, ethics, literature research, and final projects where students evaluate real tools and workflows. I liked that the course does not stop at theory. It asks students to use tools, question them, and explain where they help and where they do not.We also get into something that matters far beyond veterinary medicine: professional responsibility. If AI is involved in a workflow, the clinician is still responsible. That includes fabricated citations, bad outputs, weak prompts, and the temptation to trust tools too quickly. Candice makes a strong case that AI education needs ethics, legal context, and interdisciplinary teaching built in from the start.If you are trying to think more clearly about AI in pathology, education, workflow design, or professional training, this episode gives you a concrete example of what responsible AI literacy can look like.Episode Highlights00:00 – Why AI tools are just tools, and why trying them matters even if you later decide not to keep using them00:33 – Who Candice Chu is and why her work on AI literacy in veterinary medicine is worth paying attention to02:33 – Why going back to Texas A&M changed the scale of Candice's AI research and teaching07:53 – How the AI course was designed as a low-stakes elective first, and why that helped student engagement11:16 – Where veterinary AI education stands now, and what professional organizations like ACVP are doing13:08 – Why AI adoption in veterinary medicine is still slow, and what skepticism usually sounds like in practice15:19 – Real examples of how Candice uses LLMs and computer vision in pathology, medical records, and research19:58 – What is actually inside the 15-week AI literacy curriculum, from fundamentals to final projects24:16 – Why ethics and legal responsibility are not optional in AI education31:35 – Why no-code tools and vibe coding are entering the curriculum already38:50 – The AI tools Candice is testing in her own workflow, including Claude, Codex, and PerplexityResources mentionedCandice Chu's AI literacy curriculum framework paper in Frontiers in Veterinary ScienceCandice's earlier work on ChatGPT in veterinary medicineTexas A&M and the institutional setting where Candice is building AI research and teachingMr. Don Riddick and the AVMA AI working group, mentioned in the ethics and legal contextClaude, Codex, and Perplexity as AI tools Candice is actively testingDigital Pathology 101, mentioned in the conversation as a teaching resourceCandice's online educational work on Instagram.Support the showGet the "Digital Pathology 101" FREE E-book and join us!

In Part 2 of The Mechanics of Magick: Drumming, Trance, and the Brain, we follow rhythm from the sacred road into the war road and the modern machine. This episode examines war drums, military cadence, synchronized movement, crowd power, ritual physiology, propaganda, slogans, media framing, algorithmic repetition, moral-emotional contagion, and the illusory truth effect. The argument is not that rhythm is evil. The argument is that rhythm is morally flexible and powerful. It can heal, gather, strengthen, command, manipulate, or capture depending on the world built around it. The drum teaches us to hear the visible pulse first, so we can recognize the hidden drums of the modern world: the chant, the slogan, the feed, the notification loop, the soundtrack, the repeated frame, and the rhythm that trains attention before thought has time to speak.Links For The Occult Rejectshttps://linktr.ee/theoccultrejectsOccult Research Institutehttps://www.occultresearchinstitute.org/Substackhttps://substack.com/@theoccultrejects?r=7auau0&utm_campaign=profile&utm_medium=profile-pageCash Apphttps://cash.app/$theoccultrejectsVenmo@TheOccultRejectsBuy Me A Coffeebuymeacoffee.com/TheOccultRejectsPatreonhttps://www.patreon.com/TheOccultRejectsRhythm, Marching, Synchrony, and the GroupBodyMcNeill, William H. Keeping Together in Time: Dance and Drill in Human History. Cambridge, MA: Harvard University Press, 1995.Use for dance, drill, marching, synchronized movement, and “muscular bonding.” This is one of the best historical anchors for the claim that moving together in time can help bind human groups through the body. It belongs in the war drum, marching, military cadence, procession, and crowd-power material.Wiltermuth, Scott S., and Chip Heath. “Synchrony and Cooperation.” Psychological Science 20, no. 1 (2009): 1–5.Use for the claim that synchronized action can increase cooperation. This supports the argument that marching, chanting, dancing, and acting in time can alter group attachment and behavior.Hove, Michael J., and Jane L. Risen. “It's All in the Timing: Interpersonal Synchrony Increases Affiliation.” Social Cognition 27, no. 6 (2009): 949–960.Use for interpersonal synchrony and affiliation. This supports the softer social-bonding side of rhythm: people who coordinate timing can feel more connected.Tarr, Bronwyn, Jacques Launay, and Robin I. M. Dunbar. “Music and Social Bonding: ‘Self-Other' Merging and Neurohormonal Mechanisms.” Frontiers in Psychology 5 (2014): 1096.Use for music, synchrony, bonding, self-other merging, endorphins, and why rhythmic group activity can feel socially powerful. This belongs in both crowd sections and the “operator as instrument” material.Reddish, Paul, Ronald Fischer, and Joseph Bulbulia. “Let's Dance Together: Synchrony, Shared Intentionality and Cooperation.” PLOS ONE 8, no. 8 (2013): e71182.Use as extra support for synchrony and cooperation. Good optional source if you want more than Wiltermuth and Heath.Ritual Physiology, Crowd Arousal, and Collective EffervescenceKonvalinka, Ivana, Dimitris Xygalatas, Joseph Bulbulia, Uri Schjødt, Else-Marie Jegindø, Sebastian Wallot, Guy Van Orden, and Andreas Roepstorff. “Synchronized Arousal Between Performers and Related Spectators in a Fire-Walking Ritual.” Proceedings of the National Academy of Sciences 108, no. 20 (2011): 8514–8519.Use for the strongest fire-walking physiology source. This is the study showing synchronized arousal between active ritual performers and related spectators. It supports the claim that intense ritual fields can show up in bodies, not only in symbols.Xygalatas, Dimitris, Ivana Konvalinka, Joseph Bulbulia, and Andreas Roepstorff. “Quantifying Collective Effervescence: Heart-Rate Dynamics at a Fire-Walking Ritual.” Communicative & Integrative Biology 4, no. 6 (2011): 735–738.Use as a shorter interpretive companion to the PNAS fire-walking study. Good for the phrase “collective effervescence” and for explaining shared heart-rate dynamics in accessible language.Xygalatas, Dimitris. Ritual: How Seemingly Senseless Acts Make Life Worth Living. New York: Little, Brown Spark, 2022.Use for ritual, pain, synchrony, group bonding, arousal, and embodied social meaning. This is useful when moving from older ritual containers into modern crowd and spectacle.Hobson, Nicholas M., Juliana Schroeder, Jane L. Risen, Dimitris Xygalatas, and Michael Inzlicht. “The Psychology of Rituals: An Integrative Review and Process-Based Framework.” Personality and Social Psychology Review 22, no. 3 (2018): 260–284.Use for ritual as emotion regulation, performance regulation, social bonding, and formalized action. This supports the “ritual does things, it does not merely represent things” argument.War, Crowds, Mass Movements, and Collective IdentityLe Bon, Gustave. The Crowd: A Study of the Popular Mind. 1895.Use carefully. Le Bon is historically important for crowd psychology, but outdated and often elitist. Good as a historical source on crowd fear and mass suggestion, but balance it with modern social psychology.Canetti, Elias. Crowds and Power. New York: Viking Press, 1962.Use for a literary-philosophical treatment of crowds, power, command, fear, and collective bodies. Good for atmosphere and conceptual framing, not as a modern experimental source.Hoffer, Eric. The True Believer: Thoughts on the Nature of Mass Movements. New York: Harper & Brothers, 1951.Use for mass movements, fanaticism, belonging, identity, resentment, sacrifice, and the psychology of ideological devotion. Use carefully; it is sharp and useful, but not a modern empirical study.Tajfel, Henri, and John C. Turner. “An Integrative Theory of Intergroup Conflict.” In The Social Psychology of Intergroup Relations, edited by William G. Austin and Stephen Worchel, 33–47. Monterey, CA: Brooks/Cole, 1979.Use for social identity theory, in-groups, out-groups, belonging, status, and group comparison. This supports the claim that slogans and group language do not only communicate ideas; they also mark identity.Tajfel, Henri. Human Groups and Social Categories: Studies in Social Psychology. Cambridge: Cambridge University Press, 1981.Use as a broader social-identity source. Good for group belonging, categorization, prejudice, and in-group/out-group dynamics.Propaganda, Symbols, Slogans, and Mass CommunicationLasswell, Harold D. Propaganda Technique in the World War. New York: Alfred A. Knopf, 1927.Use for propaganda as symbolic management, war messaging, enemy construction, morale, and the manipulation of attitudes through stories, reports, images, rumors, and other significant symbols. This is a core Part 2 source.Lasswell, Harold D. “The Theory of Political Propaganda.” The American Political Science Review 21, no. 3 (1927): 627–631.Use for the clean definition: propaganda as the management of collective attitudes through significant symbols. This is perfect for the slogan/crowd/media rhythm sections.Ellul, Jacques. Propaganda: The Formation of Men's Attitudes. Translated by Konrad Kellen and Jean Lerner. New York: Alfred A. Knopf, 1965.Use for propaganda as a modern social technique, not merely lies. Ellul belongs in the “modern machine” argument because he treats propaganda as environmental, repetitive, social, technological, and tied to belonging.Bernays, Edward. Propaganda. New York: Horace Liveright, 1928.Use for public relations, engineered consent, mass persuasion, and the management of public opinion. Good supporting source, especially if you want advertising and PR to sit beside political propaganda.Herman, Edward S., and Noam Chomsky. Manufacturing Consent: The Political Economy of the Mass Media. New York: Pantheon Books, 1988.Use if you want a media-system critique: institutional filtering, agenda power, elite framing, and consent formation. This is useful for Part 2 but has a more political-economy angle than the rhythm/trance argument.Media Framing, Agenda-Setting, and Repeated AttentionMcCombs, Maxwell E., and Donald L. Shaw. “The Agenda-Setting Function of Mass Media.” Public Opinion Quarterly 36, no. 2 (1972): 176–187.Use for agenda-setting: media may not tell people exactly what to think, but it can influence what people think about and how important issues feel. This fits the “repetition trains attention” argument.Entman, Robert M. “Framing: Toward Clarification of a Fractured Paradigm.” Journal of Communication 43, no. 4 (1993): 51–58.Use for framing: selecting certain aspects of reality and making them more salient. This supports the section on media frames as secular ritual structures that define problems, causes, moral judgments, and remedies.Gitlin, Todd. The Whole World Is Watching: Mass Media in the Making and Unmaking of the New Left. Berkeley: University of California Press, 1980.Use if you want a historical case study on media framing and protest movements. Good optional source for how movements get shaped, simplified, or distorted by media attention.Postman, Neil. Amusing Ourselves to Death: Public Discourse in the Age of Show Business. New York: Viking Penguin, 1985.Use as cultural/media theory support for entertainment, spectacle, image, and public discourse. Useful for the “modern machine” angle, but more essayistic than experimental.Repetition, Familiarity, and the Illusory Truth EffectHasher, Lynn, David Goldstein, and Thomas Toppino. “Frequency and the Conference of Referential Validity.” Journal of Verbal Learning and Verbal Behavior 16, no. 1 (1977): 107–112.Use for the classic repetition/familiarity basis of the illusory truth effect. This supports the claim that repeated statements can gain perceived validity because they become easier and more familiar to processAlso want to remind people about the website, if you're into reading we have tons of information by multiple contributors, and we got t-shirts up on the site if you're interested. Fun fact, the art is all based on the eyeball. 

Women are often told to be careful with aging bones. Go light. Don't lift heavy. In this episode, I break down why that advice is backward, and what the research says to do instead.After menopause, bone and muscle break down at the same time, driven by the same drop in estrogen, and almost no one connects those dots for you. I cover how fast women lose bone, why muscle loss tracks right alongside it, why women carry more risk than men, and why heavy strength training is the most proven way to fight back.We dig into the landmark LIFTMOR trial, where postmenopausal women with low bone mass lifted heavy, safely, and built bone in the places that tend to break, plus evidence that strength training works into your 90s and a simple way to start if heavy lifting feels intimidating.In this episode:How fast women lose bone after menopauseWhy osteoporosis stays silent until something breaksHow muscle loss tracks alongside bone lossWhat the LIFTMOR trial proved about lifting with low bone massWhy intensity matters, and why it's never too late to startStudies referenced:Bone loss & resistance training (Frontiers in Physiology, 2023): https://pmc.ncbi.nlm.nih.gov/articles/PMC9941565/Muscle loss meta-analysis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9739568/Women's sarcopenia risk & first-line treatment (Frontiers in Public Health, 2025): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12883749/LIFTMOR Trial (Watson et al., 2018): https://pubmed.ncbi.nlm.nih.gov/28975661/Strength training to age 96: https://pubmed.ncbi.nlm.nih.gov/10721690/Train with us at Prepare for Performance (PFP) in Rockville, MD, serving the DMV.

If cardio has you in a chokehold because summer is around the corner, this episode is going to free you.This episode was inspired by two DMs we receive constantly. The woman who's already doing cardio most days and wondering if she should just do more. And the woman who's been lifting consistently for months, getting stronger, but not feeling any leaner, and wondering if weights are actually overrated for fat loss.If you've ever been either of those people, you're in the right place.We then unpack a 2026 study from Tel Aviv University published in Frontiers in Endocrinology (PMID: 41625248), 304 real people, real(ish) context, that makes the case for resistance training more clearly than almost anything else in the current literature. Including a finding about visceral fat that will completely reframe the way you think about belly fat.

The Blasters & Blades PodcastWhat happens to humanity when we leave civilization behind? This week, our panel ventures out past the safety of the perimeter to explore the concept of the frontier in sci-fi, fantasy, and horror. From the lawless outer rims of distant galaxies to the monster-infested borders of uncharted magical wilderness, we are dissecting why the “edge of the map” remains the ultimate testing ground for the human spirit. Join us as we discuss the grit, the isolation, and the terrifying freedom that can only be found when you cross the line into the untamed unknown. This was a fun interview, so check out this episode. Lend us your eyes and ears, you won't be sorry!! Co-Hosts: JR Handley (Author) (Grunt)Nick Garber (Comic Book Artist) (Super Grunt)Jana S Brown (Author) (Chief Shenanigator)We work for free, so if you wanna throw a few pennies our way there is a linked Buy Me A Coffee site where you can do so. Just mention the podcast in the comments when you donate, and I'll keep the sacred bean water boiling!Support the Show: https://www.buymeacoffee.com/AuthorJRHandley Our LinkTree: https://linktr.ee/blastersandbladespodcast Today's SponsorThe Shamans Bones by Hunter Kay Wallace: https://a.co/d/0bhW88F8 Follow Bill McUisdean (Wylder396) on social mediaBill's Website: https://zorne.substack.com/ Bill's Substack: https://substack.com/@wylder396 Bill's Twitter: https://x.com/Wylder396 Follow Jana S Brown on social mediaJana's Amazon: https://www.amazon.com/stores/Jana-S.-Brown/author/B015VJV7JW Jana's Website: www.opalkingdompress.com Jana's Facebook: www.facebook.com/janasbrownwrites Jana's LinkTree: https://linktr.ee/opalkingdompress Follow Jena Rey on social mediaJena's Amazon: https://www.amazon.com/stores/Jena-Rey/author/B08XSCHXYX Follow Jesse James Fain on social mediaJesse's Amazon: http://amazon.com/author/jessejamesfain Jesse's Website: https://outlawauthor.com/ Jesse's Twitter: https://x.com/JesseJamesBooks Jesse's Instagram: https://www.instagram.com/JesseJamesFain Jesse's Reddit: https://www.reddit.com/user/OutlawAuthor/ Jesse's Substack: https://jessejamesfain.substack.com/Follow JR Handley on social mediaJR's Amazon: https://www.amazon.com/stores/J.-R.-Handley/author/B01N0SEX3A JR's Website: https://jrhandley.com/ JR's Facebook: https://www.facebook.com/sgt.jr.handley JR's Substack: https://jrhandley.substack.com/ Follow Keith Hedger on social mediaKeith's Amazon: https://www.amazon.com/Keith-Hedger/e/B01N2V9383/ Keith's Website: https://www.keithhedger.com/ Keith's Facebook: https://www.facebook.com/KeithHedgerAuthor/ Keith's Twitter: https://x.com/KHedger30260 Follow Melissa McShane on social mediaMelissa's Amazon: https://www.amazon.com/stores/Melissa-McShane/author/B00TON8E1Q Melissa's Website: www.melissamcshanewrites.com Melissa's Facebook: www.facebook.com/melissamcshanewrites Melissa's Discord: https://discord.gg/wKXUe89Kh7 Melissa's Store: http://www.nightharborpress.com/ #scifishenanigans #scifishenaniganspodcast #bbp #blastersandblades #blastersandbladespodcast #podcast #scifipodcast #fantasypodcast #scifi #fantasy #books #rpg #comics #fandom #literature #comedy #veteran #army #armyranger #ranger #scififan #redshirts #scifiworld #sciencefiction #scifidaily #scificoncept #podcastersofinstagram #scificons #podcastlife #podcastsofinstagram #scifibooks #awardwinningscifi #newepisode #podcastersofinstagram #podcastaddict #podcast #scifigeek #scifibook #sfv #scifivisionaries #firesidechat #chat #panel #fireside #religionquestion #coffee #tea #coffeeortea #CoffeeBrandCoffee #JRHandley #NickGarber #MadamStabby #JanaSBrown #JenaRey #OpalKingdomPress #frontier #Frontiers #speculativefictionfrontier #BillMcUisdean #Wylder396 #JesseJamesFain #OutlawAuthor #OutlawAuthorJesseJames #OutlawAuthorJesseJamesFain #KeithHedger #MelissaMcShane #Warmaster #WarMistress #Warhamster #HunterKayWallace #ShamansBones

Fish Oil Supplements And Alzheimer's-Related Decline A two-year randomized, double-blind, placebo-controlled trial led by researchers at USC tested whether 2,000 mg of DHA fish oil daily could slow Alzheimer's-related brain changes in 365 adults ages 55–80 who rarely consumed fish and had at least one Alzheimer's risk factor. Researchers confirmed the supplement reached the brain by measuring a roughly 17% increase in cerebrospinal fluid DHA after six months. Despite successfully increasing brain DHA levels, participants taking fish oil showed no significant improvements in memory, global cognitive function, or hippocampal volume compared to placebo after two years. Host Dave Asprey explains why raising a single biomarker doesn't always translate into better brain performance, why nutrition works differently inside a complete dietary pattern than as an isolated supplement, and what this study means for anyone relying on fish oil as an Alzheimer's prevention strategy. Sources: https://medicalxpress.com/news/2026-06-fish-oil-supplements-alzheimer-decline.pdf https://www.cnn.com/2026/06/18/health/omega-3-fish-oil-algae-supplement-wellness ~~ DASH Diet Showed the Strongest Link to Long-Term Brain Health Researchers from Harvard analyzed dietary data from 159,347 participants across three long-running U.S. health studies to examine how eating patterns influence cognitive aging. Participants completed dietary questionnaires every four years over several decades, allowing investigators to compare six healthy dietary patterns, including the DASH and Mediterranean diets. While all six were associated with better cognitive health later in life, adherence to the DASH diet produced the strongest association, with participants showing roughly a 40% lower risk of subjective cognitive decline and stronger performance on objective cognitive testing. The protective relationship was strongest when healthy eating habits began during midlife. Host Dave Asprey breaks down why blood sugar control, lower inflammation, and healthier blood vessels may be the real drivers behind long-term brain resilience, and why your dietary choices in your 40s and 50s may have an outsized impact on cognitive aging decades later. Sources: https://jamanetwork.com/journals/jamaneurology/article-abstract/2845466 https://www.health.harvard.edu/diet-and-nutrition/harvard-study-six-healthy-diets-linked-with-better-long-term-brain-health https://www.eurekalert.org/news-releases/1117225 ~~ Scientists Identified an Ancient Brain Circuit That Filters Distractions Johns Hopkins researchers discovered a small population of inhibitory neurons within an evolutionarily ancient brainstem region that appears to control selective attention by determining which sensory information deserves focus and which distractions should be ignored. Mice trained on visual attention tasks consistently ignored irrelevant stimuli until researchers temporarily silenced these neurons, causing even weak distractions to hijack their attention while leaving vision and movement otherwise unaffected. Similar brain circuits exist in birds, reptiles, and other vertebrates, suggesting this attentional filtering system evolved long before the modern human cortex. Host Dave Asprey explains why attention may depend on much older brain circuitry than previously believed, how this discovery could reshape our understanding of ADHD and autism, and why future therapies may target the brainstem instead of the prefrontal cortex. Sources: https://www.sciencedaily.com/releases/2026/06/260624025426.htm ~~ Nearly Half of Older Adults Improved With Age Instead of Declining A Yale-led study followed 11,340 adults age 65 and older for up to 12 years using repeated measurements of cognition and walking speed to better understand how aging changes over time. Rather than finding universal decline, researchers discovered that 45% of participants improved in either cognitive function, physical performance, or both. Nearly one-third experienced measurable cognitive improvements, while over one-quarter improved physically. Researchers also found that participants with more positive beliefs about aging were significantly more likely to improve, even after accounting for education, chronic illness, depression, and other health factors. Host Dave Asprey explores why expectations about aging may become biologically embedded, why decline is far less inevitable than conventional medicine often assumes, and how mindset may directly influence healthy longevity. Sources: https://www.sciencedaily.com/releases/2026/06/260620100428.htm ~~ Glyphosate May Be Contributing to Antibiotic-Resistant Superbugs Researchers publishing in Frontiers in Microbiology examined 102 bacterial strains collected from hospitals, agricultural land, and protected wetlands to investigate whether glyphosate exposure contributes to multidrug antibiotic resistance. Hospital bacteria demonstrated extensive resistance to both antibiotics and glyphosate, while even bacteria living inside protected nature reserves displayed measurable glyphosate resistance despite no direct herbicide application. Genetic analysis suggested resistant bacterial strains may move between agricultural environments and hospitals through shared waterways and sediments. The researchers argue pesticide safety testing should also evaluate whether chemicals encourage antibiotic resistance, one of the world's fastest-growing public health threats. Host Dave Asprey explains why environmental toxins may have unintended effects on the human microbiome, how herbicides could influence antimicrobial resistance beyond farming, and why environmental biology increasingly belongs in conversations about human health. Sources: https://www.sciencedaily.com/releases/2026/06/260620100434.htm https://www.openaccessgovernment.org/common-weedkiller-glyphosate-linked-to-rise-in-superbugs-scientists-warn/207515/ ~~ Butterflies That Barely Age Could Unlock New Longevity Pathways Researchers from the University of Bristol found that Heliconius butterflies live dramatically longer than closely related butterfly species while aging much more slowly. In one comparison, Heliconius hewitsoni survived up to 348 days, while a closely related species lived only 14 days. Unlike most butterflies, Heliconius feed on pollen throughout adulthood, providing amino acids that help preserve muscle function and physical performance with age. However, even when pollen was removed, these butterflies still significantly outlived their relatives, suggesting evolved genetic and metabolic mechanisms also contribute to their exceptional longevity. Host Dave Asprey explores why nature continues to provide unexpected models for slowing biological aging, what scientists hope to learn from species that naturally maintain function over time, and how comparative biology may uncover entirely new pathways for extending human healthspan. Sources: https://www.sciencedaily.com/releases/2026/06/260622014302.htm ~~ This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want mechanism-level insights into omega-3 supplementation and Alzheimer's prevention, nutrition strategies for preserving cognitive health, newly discovered brain circuits controlling attention, the surprising biology behind healthy aging, environmental drivers of antibiotic resistance, and what one remarkably long-lived butterfly can teach us about extending healthspan. Host Dave Asprey connects randomized clinical trials, large population studies, neuroscience discoveries, microbiology research, and evolutionary biology into practical frameworks for improving brain performance, resilience, and longevity. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: fish oil Alzheimer's study, DHA supplements memory, omega-3 brain health, DASH diet cognition, dementia prevention diet, cognitive decline nutrition, selective attention brainstem, focus neuroscience, ADHD brain research, positive aging beliefs, healthy aging study, cognitive improvement older adults, glyphosate antibiotic resistance, superbugs glyphosate, environmental toxins microbiome, butterfly longevity research, Heliconius aging, longevity science, biohacking news 2026, Dave Asprey, The Human Upgrade Thank you to our sponsors! - Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today - Neuronic | Go to www.neuronic.online Code DAVE for $100 off - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:18 – Story #1 Fish Oil 02:31 – Story #2 DASH Diet 03:49 – Story #3 Brain Stem Attention Filter 05:59 – Story #4 Cognitive Decline Lies 08:24 – Story #5 Glyphosate 10:16 – Story #6 Butterfly Lifespan Research 12:16 – Biohacking Criticism Response See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode, we sit down with Dr. Greg Eckel to discuss Parkinson's disease, neurodegenerative disorders, and some of the most common misconceptions surrounding brain health. As a naturopathic physician and pioneer in regenerative medicine, Dr. Eckel has spent more than two decades exploring innovative approaches to supporting neurological function and improving quality of life for patients facing complex brain-related conditions. Dr. Eckel is the founder of bVital in Park City, Utah, and the creator of the Eckel Protocol®, an integrative approach that combines regenerative therapies, bioenergetics, and advanced health technologies. His work focuses on helping individuals optimize brain function, address chronic neurological challenges, and support long-term cognitive health. This conversation explores: Common myths and misconceptions about Parkinson's disease. The role of neuroinflammation in brain health and neurodegenerative conditions. Emerging approaches to brain regeneration and neurological recovery. How lifestyle, nutrition, and integrative medicine may support cognitive function. Dr. Eckel's interest in brain regeneration was deeply influenced by his personal experience caring for his wife during her battle with Creutzfeldt-Jakob disease. That journey led him to investigate regenerative medicine, neuroinflammation, and innovative therapeutic approaches designed to support the brain's natural healing processes. Today, his work incorporates a wide range of tools, including naturopathic medicine, Chinese medicine, regenerative therapies, mind-body practices, and emerging health technologies. A sought-after speaker and educator, Dr. Eckel has been featured on major media outlets, including ABC, NBC, and FOX. He is also the author of Shake It Off: An Integrative Approach to Parkinson's Solutions and has reached thousands through his educational programs focused on brain health, neuroplasticity, and regenerative medicine. Connect with Dr. Eckel: LinkedIn Instagram BrainRegen bVital Facebook X Youtube

SEGMENTS | The Mary Brickell Story in Miami | Spain in The American Revolution | Remembering The Civil War in Orlando

Many women are prescribed oral estrogen without ever being told what happens after it enters the body. In this episode, Dr. Brendan McCarthy takes a deeper look at estrone, the estrogen metabolite created when estradiol is taken orally, and explains why the delivery method of hormone therapy matters. You'll learn: The difference between estradiol and estrone Why oral estrogen creates significantly higher estrone levels How estrone may contribute to inflammation and insulin resistance The connection between estrogen metabolism and weight gain during perimenopause and menopause Why monitoring labs is essential when using hormone therapy The importance of understanding risks, benefits, and treatment options before starting hormones Dr. McCarthy also discusses the role of inflammation, body fat, metabolic health, and hormone delivery systems in creating long-term outcomes for women navigating menopause. This episode is about education, informed consent, and helping women better understand the science behind their care.   Citations: There is more than one estrogen; after menopause, estrone dominates Kuhl, Herbert. “Pharmacology of Estrogens and Progestogens: Influence of Different Routes of Administration.” Climacteric, vol. 8, no. S1, 2005, pp. 3–63. Body fat is an endocrine organ — aromatase converts androstenedione into estrone, and adipose becomes the dominant post-menopausal estrogen source Lee, Angel A., and Laura J. Den Hartigh. “Metabolic Impact of Endogenously Produced Estrogens by Adipose Tissue in Females and Males across the Lifespan.” Frontiers in Endocrinology, vol. 16, 2025, article 1682231. Inflamed fat raises IL-6; IL-6 tracks the insulin-resistant state Kern, Philip A., et al. “Adipose Tissue Tumor Necrosis Factor and Interleukin-6 Expression in Human Obesity and Insulin Resistance.” American Journal of Physiology-Endocrinology and Metabolism, vol. 280, no. 5, 2001, pp. E745–E751. IL-6 is part of the insulin-resistance machinery — it correlates with impaired insulin-stimulated glucose uptake Bastard, Jean-Philippe, et al. “Adipose Tissue IL-6 Content Correlates with Resistance to Insulin Activation of Glucose Uptake Both In Vivo and In Vitro.” The Journal of Clinical Endocrinology & Metabolism, vol. 87, no. 5, 2002, pp. 2084–2089. Inflammation amplifies aromatase — IL-6 raises aromatase via COX-2/PGE2 Bowers, Laura W., et al. “Obesity-Associated Systemic Interleukin-6 Promotes Pre-Adipocyte Aromatase Expression via Increased Breast Cancer Cell Prostaglandin E2 Production.” Breast Cancer Research and Treatment, vol. 149, no. 1, 2015, pp. 49–57. Human-tissue confirmation: HOMA-IR, IL-6, insulin, leptin, hsCRP track breast aromatase after menopause Brown, Kristy A., et al. “Menopause Is a Determinant of Breast Aromatase Expression and Its Associations with BMI, Inflammation, and Systemic Markers.” The Journal of Clinical Endocrinology & Metabolism, vol. 102, no. 5, 2017, pp. 1692–1701. Iyengar, Neil M., et al. “Effects of Obesity on Breast Aromatase Expression and Systemic Metabo-Inflammation in Women with BRCA1 or BRCA2 Mutations.” npj Breast Cancer, vol. 7, no. 1, 2021, article 18. The molecular crux: estrone drives ERα/NF-κB inflammatory signaling while estradiol opposes it Qureshi, Rehana, et al. “The Major Pre- and Postmenopausal Estrogens Play Opposing Roles in Obesity-Driven Mammary Inflammation and Breast Cancer Development.” Cell Metabolism, vol. 31, no. 6, 2020, pp. 1154–1172.e9. Estrone as a metabolic-risk signal — prospectively associated with diabetes (note: male cohort) Jasuja, Guneet Kaur, et al. “Circulating Estrone Levels Are Associated Prospectively with Diabetes Risk in Men of the Framingham Heart Study.” Diabetes Care, vol. 36, no. 9, 2013, pp. 2591–2596.   Dr. Brendan McCarthy is the founder and Chief Medical Officer of Protea Medical Center in Arizona. With over two decades of experience, he's helped thousands of patients navigate hormonal imbalances using bioidentical HRT, nutrition, and root-cause medicine. He's also taught and mentored other physicians on integrative approaches to hormone therapy, weight loss, fertility, and more. If you're ready to take your health seriously, this podcast is a great place to start.

If you think executive function challenges only affect your ADHD and autism clients, this episode will change how you see your entire caseload. In this episode, we break down the latest 2025 research, revealing that executive function difficulties are far more widespread than previously recognized, including in populations SLPs have historically underestimated. You'll learn: Adele Diamond's 3-part framework for understanding executive function (attention and inhibitory control, verbal working memory, and cognitive flexibility) Why do children with developmental language disorder almost universally show verbal working memory deficits across all ages and native languages The surprising finding that even children with mild articulation errors, like distorted R's and S's, show statistically significant executive function risk New 2025 data linking stuttering to verbal and visual working memory difficulties How Universal Design for Learning (UDL) principles can help you build one powerful, inclusive activity that targets executive function across your whole caseload The bottom line: We need to stop treating a mouth and start treating the whole child. Next week: Part 2 covers what the research says actually works to improve executive function and how to bring it into your sessions starting Monday. References: Afshar, M., Zarifian, T., Khorrami Banaraki, A., & Noroozi, M. (2022). Executive functions in Persian-speaking preschool children with speech sound disorders and comparison with their typically developing peers. Applied Neuropsychology: Child, 11(4), 702–712. https://doi.org/10.1080/21622965.2021.1937169 Kakuta, K., et al. (2025). Executive function in preschool children who stutter: A behavioral assessment study. Scientific Reports, 15(1), Article 16159. https://doi.org/10.1038/s41598-025-00981-9 Lee, D., Boulton, K. A., Sun, C., Phillips, N. L., Munro, M., Kumfor, F., Demetriou, E. A., & Guastella, A. J. (2024). Attention and executive delays in early childhood: A meta-analysis of neurodevelopmental conditions. Molecular Psychiatry. Advance online publication. Niu, T., Wang, S., Ma, J., Zeng, X., & Xue, R. (2024). Executive functions in children with developmental language disorder: A systematic review and meta-analysis. Frontiers in Neuroscience, 18, Article 1390987. https://doi.org/10.3389/fnins.2024.1390987 Keywords: executive function, speech language pathology, developmental language disorder, speech sound disorders, apraxia of speech, stuttering, verbal working memory, UDL, SLP caseload, 2025 research

How This Is Building Me, hosted by world-renowned oncologist D. Ross Camidge, MD, PhD, is a podcast focused on the highs and lows, ups and downs of all those involved with cancer, cancer medicine, and cancer science across the full spectrum of life's experiences.In this episode, Dr Camidge sat down with Mary (Nora) L. Disis, MD, a professor in the Clinical Research Division at Fred Hutchinson Cancer Center; as well as a professor in the Division of Hematology and Oncology, an adjunct professor of pathology in obstetrics and gynecology, holder of the Helen B. Slonaker Endowed Professorship for Cancer Research, director of the Cancer Vaccine Institute, and associate dean for Translational Health Science at the School of Medicine at the University of Washington in Seattle.Drs Camidge and Disis discussed Dr Disis's evolution from a science-focused student to a global leader in cancer immunology. Raised in a family that prioritized education, Disis found her passion for chemistry as a young adult before pursuing an MD and a master's degree. Although deeply drawn to practicing medicine in rural communities, she ultimately chose to focus on the field of tumor immunology.In the discussion, Disis offered a candid look at the strategic discipline required to succeed as a clinician-scientist. She emphasized the importance of protecting research time and refusing to let clinical duties overshadow her lab work. Her pioneering research involved identifying HER2 as a tumor antigen and developing vaccines that demonstrated significant long-term survival through intermolecular epitope spreading.Beyond the lab, Disis highlighted how her editorial roles allow her to observe scientific trends and maintain a broad understanding of the clinical landscape. Ultimately, Disis emphasized that the path to cancer prevention and vaccine licensing requires finance, focus, fortitude, and fearlessness. Having witnessed immunotherapy become a standard of care, she remains dedicated to climbing the mountain of vaccine development. By sifting through scientific “buzz” and maintaining deep focus, Disis believes the next frontier of cancer research lies in immunizing individuals to prevent cancer from ever developing.

Links For The Occult Rejectshttps://linktr.ee/theoccultrejectsOccult Research Institutehttps://www.occultresearchinstitute.org/Substackhttps://substack.com/@theoccultrejects?r=7auau0&utm_campaign=profile&utm_medium=profile-pageCash Apphttps://cash.app/$theoccultrejectsVenmo@TheOccultRejectsBuy Me A Coffeebuymeacoffee.com/TheOccultRejectsPatreonhttps://www.patreon.com/TheOccultRejectsPart 1 focuses on the drum as an ancient technology of altered consciousness. The argument is not that every beat causes trance, or that neuroscience has proven spirits. The stronger argument is that rhythm enters the human organism through hearing, motor prediction, breath, movement, attention, emotion, expectation, culture, and social synchrony. The drum becomes powerful when sound, body, group, ritual frame, and meaning converge. These sources support the archaeology, neuroscience, EEG research, shamanic studies, possession studies, Indigenous and culturally specific drum traditions, ritual theory, placebo and meaning-response research, ceremonial magic, and modern witchcraft material used in the episode.Core Academic and Scientific SourcesHuels, Emma R., Hyoungkyu Kim, UnCheol Lee, Tirsa Bel-Bahar, Ana V. Colmenero, Alexandra Nelson, Stefanie Blain-Moraes, George A. Mashour, and Richard E. Harris. “Neural Correlates of the Shamanic State of Consciousness.” Frontiers in Human Neuroscience 15 (2021): 610466.Gordon, Yoel, Golan Karvat, Noa Dagan, and Ayelet N. Landau. “Neural Tracking at Theta Predicts Drumming-Induced Altered States of Consciousness.” Scientific Reports 16, no. 1 (2026): Article 10204.Aparicio-Terrés, R., et al. “The Neurobiology of Altered States of Consciousness Induced by Drumming and Other Rhythmic Sound Patterns.” Annals of the New York Academy of Sciences, 2025.Neher, Andrew. “Auditory Driving Observed with Scalp Electrodes in Normal Subjects.” Electroencephalography and Clinical Neurophysiology 13 (1961): 449–451.Neher, Andrew. “A Physiological Explanation of Unusual Behavior in Ceremonies Involving Drums.” Human Biology 34, no. 2 (1962): 151–160.Maurer, R., V. K. Kumar, L. Woodside, and R. J. Pekala. “Phenomenological Experience in Response to Monotonous Drumming and Hypnotizability.” American Journal of Clinical Hypnosis 40, no. 2 (1997): 130–145. Use for monotonous drumming, subjective altered experience, imagery, absorption, and hypnotizability.Maxfield, Melinda C. “Effects of Rhythmic Drumming on EEG and Subjective Experience.” PhD diss., Institute of Transpersonal Psychology, 1990. Use as older supporting context on drumming, EEG, imagery, body-image changes, and subjective altered experience. Do not make this the main scientific proof; use it as background.Nozaradan, Sylvie, Isabelle Peretz, and André Mouraux. “Tagging the Neuronal Entrainment to Beat and Meter.” The Journal of Neuroscience 31, no. 28 (2011): 10234–10240. Use for EEG evidence that the brain can track beat and meter. This supports the claim that the brain does not merely hear rhythm as background sound; it can represent rhythmic structure in measurable ways.Nozaradan, Sylvie. “Exploring How Musical Rhythm Entrains Brain Activity with Electroencephalogram Frequency-Tagging.” Philosophical Transactions of the Royal Society B 369, no. 1658 (2014). Use as broader rhythm/EEG entrainment support. This helps explain frequency-tagging, beat tracking, meter, neural entrainment, and the measurable relationship between rhythmic structure and brain activity.Thaut, Michael H., Gerald C. McIntosh, and Volker Hoemberg. “Neurobiological Foundations of Neurologic Music Therapy: Rhythmic Entrainment and the Motor System.” Frontiers in Psychology 5 (2015). Use for rhythm as motor-system timing information. This supports the claim that a beat can become bodily instruction, not just sound for the ear. Especially useful when discussing rhythmic auditory stimulation, motor planning, gait, entrainment, and the auditory-motor bridge.Ross, Jessica M., John R. Iversen, and Ramesh Balasubramaniam. “Time Perception for Musical Rhythms: Sensorimotor Perspectives on Entrainment, Simulation, and Prediction.” 2022. Use for rhythm, timing, prediction, sensorimotor entrainment, and the way musical rhythm interacts with time perception.Hove, Michael J., and Jane L. Risen. “It's All in the Timing: Interpersonal Synchrony Increases Affiliation.” Social Cognition 27, no. 6 (2009): 949–960. Use for synchrony and social bonding. This helps support the group-body argument: moving or acting in time with others can increase affiliation.Wiltermuth, Scott S., and Chip Heath. “Synchrony and Cooperation.” Psychological Science 20, no. 1 (2009): 1–5. Use for the claim that synchronized movement can increase cooperation and attachment among participants.Tarr, Bronwyn, Jacques Launay, and Robin I. M. Dunbar. “Music and Social Bonding: ‘Self-Other' Merging and Neurohormonal Mechanisms.” Frontiers in Psychology 5 (2014): 1096. Use for music, synchrony, bonding, endorphin/social mechanisms, and why group rhythm can feel like more than private listening.Fancourt, Daisy, Rosie Perkins, Sara Ascenso, Louise Atkins, Fatima Kilfeather, and Aaron Williamon. “Effects of Group Drumming Interventions on Anxiety, Depression, Social Resilience and Inflammatory Immune Response among Mental Health Service Users.” PLOS ONE 11, no. 3 (2016): e0151136. Use for modern group-drumming research showing psychological and physiological effects, including anxiety, depression, social resilience, wellbeing, and inflammatory immune response. Use carefully: this does not make group drumming a cure-all. It supports the more grounded claim that embodied rhythm and group participation can affect mood, social connection, and body chemistry.Bittman, Barry B., et al. “Composite Effects of Group Drumming Music Therapy on Modulation of Neuroendocrine-Immune Parameters in Normal Subjects.” Alternative Therapies in Health and Medicine 7, no. 1 (2001): 38–47. Use as older supporting material on group drumming and neuroendocrine-immune measures. Keep secondary. Fancourt is cleaner for the main script body.Archaeology and Deep History of DrumsLawergren, Bo. “Neolithic Drums in China.” In Music Archaeology in China. 2006. Use for clay drums in Neolithic China and the deep-history claim that drums are not just poetic symbols of antiquity. They appear in the archaeological record as instruments tied to early sound-making, ceremony, and social order.Both, Arnd Adje. “Music Archaeology: Some Methodological and Theoretical Considerations.” Use as general support for why ancient instruments should be treated as ritual and social evidence, not merely decorative objects.Anthropology, Ethnomusicology, Ritual, and TranceRouget, Gilbert. Music and Trance: A Theory of the Relations Between Music and Possession. Translated by Brunhilde Biebuyck. Chicago: University of Chicago Press, 1985. Essential source. Use for the caution that music does not mechanically or universally cause trance. Rouget helps keep the argument academically serious by emphasizing culture, ritual frame, meaning, and expectation.Becker, Judith. Deep Listeners: Music, Emotion, and Trancing. Bloomington: Indiana University Press, 2004. Use for music-linked trancing, emotional absorption, religious experience, and culturally trained ways of listening. This supports the “hearing versus entering” distinction.McNeill, William H. Keeping Together in Time: Dance and Drill in Human History. Cambridge, MA: Harvard University Press, 1995. Use for marching, dance, drill, muscular bonding, synchronized movement, and rhythm as social glue. This is useful both for Part 1's group-body material and Part 2's war-drum material.Eliade, Mircea. Shamanism: Archaic Techniques of Ecstasy. Princeton: Princeton University Press, 1964. Use carefully. Eliade's phrase “archaic techniques of ecstasy” is powerful, but the episode should also note that later scholarship criticizes his tendency to universalize shamanism.Winkelman, Michael. Shamanism: A Biopsychosocial Paradigm of Consciousness and Healing. 2nd ed. Santa Barbara, CA: Praeger, 2010. Use for shamanism as a ritual technology involving altered consciousness, healing, social integration, symbolism, and body-brain processes.Winkelman, Michael. “Shamanism and Psychedelics: A Biogenetic Structuralist Paradigm of Ecopsychology.” European Journal of Ecopsychology 4 (2013): 90–115. Use as supplemental background on shamanism, altered consciousness, and comparative models of trance and visionary states.Kontouli, Athanasia, Michael J. Hove, Alexandre Lehmann, Peter Vuust, and Peter E. Keller. “The Rhythms of Trance: Cultural Phenomenology and Neural Mechanisms of Music-Induced Lewis-Williams, David. The Mind in the Cave: Consciousness and the Origins of Art. London: Thames & Hudson, 2002. Use cautiously for altered states, entoptic imagery, ritual vision, and the relationship between neuropsychology and symbolic culture.Non-Ordinary States of Consciousness.” Neuroscience & Biobehavioral Reviews, 2026. Use for the bridge between cultural phenomenology and neuroscience. This supports the point that music-induced trance is not only acoustics; it involves body, training, expectation, culture, environment, and interpretation.Tart, Charles T., ed. Altered States of Consciousness. New York: Wiley, 1969. Use as classic altered-state background.Hultkrantz, Åke. “The Drum in Shamanism.” Use for classic comparative material on the shamanic drum, especially Arctic, SiberiAlso want to remind people about the website, if you're into reading we have tons of information by multiple contributors, and we got t-shirts up on the site if you're interested. Fun fact, the art is all based on the eyeball. A

This episode's guests:Ken Walczak, Night Light Consulting.Mark Baker, Soft Lights Foundation.Charles Hood, Author of Nature at Night.Bill's News Picks:  Ford Government's bill 98 Could be the final Death Knell for Birds, Alexis Wright & Anushka Yadav, The Pointer. Artificial light at night disrupts immune rhythms in wild rodents under semi-natural conditions, Environmental Pollution. Chronic Artificial Light at Night Exposure Disrupts Circadian Rhythms and Modulates P53 Gene Expression in a Rat Model of Colorectal Cancer, Journal of Medicine and Health Research.  Engineering glowing plants: recent progress and future directions for application-oriented design, Frontiers in Bioengineering and Biotechnology.L.Y.R. - Dark Sky Reservation, Real World Records, Youtube.Send Feedback Text to the Show!Support the showA hearty thank you to all of our paid supporters out there. You make this show possible.For only the cost of one coffee each month you can help us to continue to grow. That's $3 a month. If you like what we're doing, if you think this adds value in any way, why not say thank you by becoming a supporter!Why Support Light Pollution News?Receive quarterly invite to join as live audience member for recordings with special Q&A session post recording with guests.Receive all of the news for that month via a special Supporter monthly mailer.Satisfaction that your support helps further critical discourse on this topic.About Light Pollution News:Ever wonder why migrating birds crash into buildings? Or why you can't sleep at night? What about where you can still see the Milky Way? Light Pollution News explores how our 24/7 lit world affects everything from wildlife and human health to our understanding of the stars, travel, and the future of our cities. Host Bill McGeeney brings on rotating guests to help dig into the latest research, policy activity, and real-world solutions - from how irresponsible lighting degrades our health to the best dark sky destinations for your next trip. Whether you're a birder, conservationist, astrophotographer, or just someone who misses sleeping in darkness, this is the show that connects the dots between your disappear...

Po co to wszystko? Po co pracujemy ponad siły, gonimy za kolejnymi celami, porównujemy się z innymi i nieustannie próbujemy być „wystarczający”? Przyglądam się w tym odcinku kulturze produktywności, presji sukcesu i pytaniu, które wielu z nas zadaje sobie w momentach zmęczenia: jaki jest sens tego wszystkiego?Usłyszysz o pułapkach kultury „wiecznego działania”, FOMO, społecznej gloryfikacji przepracowania oraz o tym, dlaczego nasza wartość nie powinna zależeć wyłącznie od osiągnięć. To odcinek o poczuciu sensu – czym jest, dlaczego ma tak ogromne znaczenie dla zdrowia psychicznego, odporności na stres i jakości życia oraz dlaczego nie da się go znaleźć w gotowej recepturze czy poradniku. Sens nie jest miejscem, do którego docieramy. Jest procesem. Tak, wiem, jak to brzmi, ale… posłuchaj sam_a. To jak myślicie, po co to wszystko?Partnerem odcinka jest @tauron_pe, który sens widzi w zielonej transformacji - z poszanowaniem tradycji, adaptacją do wyzwań współczesności. Sprawdźcie koniecznie nasze wcześniejsze partnerskie odcinki: o adaptacji, solostalgii i lęku przed zmianą. Nie pożałujecie #reklama.Napiwki za ten odcinek przyjmuję w subach, lajkach i na Patronite ;) Montaż: Eugeniusz KarlovLiteratura: Akbari, M., Seydavi, M., Palmieri, S., Mansueto, G., Caselli, G., & Spada, M. M. (2021). Fear of missing out (FoMO) and internet use: A comprehensive systematic review and meta-analysis. Journal of Behavioral Addictions, 10(4), 879-900.Baumeister R. F. (1991). Meanings of Life. New York, NY: Guilford Press.Corbella, G., Pierobon, A., & Maffoni, M. (2025). What is life worth living for? A systematic review on meaning in life and meaning in work as protective factors for healthcare professionals' wellbeing. Health psychology report, 13(2), 111–132. https://doi.org/10.5114/hpr/199541Routledge, C., & FioRito, T. A. (2021). Why Meaning in Life Matters for Societal Flourishing. Frontiers in psychology, 11, 601899. https://doi.org/10.3389/fpsyg.2020.601899Trzebinski J., Cabanski M., Czarnecka J. Z. (2020). Reaction to the COVID-19 pandemic: the influence of meaning in life, life satisfaction, and assumptions on world orderliness and positivity. J. Loss Trauma 25, 544–557. 10.1080/15325024.2020.1765098Yang, Z., Williams, S. D., Beldzik, E., Anakwe, S., Schimmelpfennig, E., & Lewis, L. D. (2025). Attentional failures after sleep deprivation are locked to joint neurovascular, pupil and cerebrospinal fluid flow dynamics. Nature neuroscience, 28(12), 2526–2536. https://doi.org/10.1038/s41593-025-02098-8

SEGMENTS | Prairie Creek Conservation Cemetery | Orlando Sentinel Publisher Martin Andersen | Florida Cracker Ponies

Discover the science behind the powerful bond between humans and animals. In this episode, we explore how interacting with animals can trigger feel‑good brain chemicals, lower stress, and support emotional well‑being. From neuroscience to real-life impact, you'll learn why these connections are more than just emotionally comforting— those furry friends will biologically improve your mental health!For more information on the studies mentioned in today's show…Frontiers in Psychology2022 Equine StudyJanuary 2015 Journal of Community and Supportive Oncology (Exact Google Seach Will Provide the Full Article in PDF Form)Our Friend (and former guest) Sandra Dee Robinson Equine Therapy in Texas USAConnect with Brain Lady JulieDo you have a great question or topic you'd like Brain Lady Julie to cover? Think you'd be a great guest? Message our producer Kelli@BrainLadySpeaker.com and let us know.PLEASE NOTE: The information contained in this podcast is not at any time and for any reason meant to replace the guidance and/or treatment of any health professional. Whether it be a medical doctor, psychologist, psychotherapist, or anyone in the medical field. If you are under the care of such a health professional, remember this is an “added value” and not designed to replace any care you are currently under.

The Dream Team has an encounter with a familiar member of the Obsidian Council and learn what's truly happening on Dhura Sancta and just how important their mission is. Flit takes decisive action in a crisis. Vlyn discovers a hiding spot. ⁠⁠Support the show on Patreon⁠⁠⁠⁠⁠⁠⁠⁠ Take part in Frontiers by joining the official Discord! ⁠⁠⁠⁠⁠⁠⁠Check out TableTone to elevate your next TTRPG experience!⁠⁠⁠ Check out Cyber Rats in Space on Kickstarter! Frontiers Theme by Grant Craven Additional Music Credits: "Balkan Background" by Roman_Sol (https://pixabay.com/music/world-balkan-background-449220/)"Darkness Approaching (Cinematic Danger)" by Grand_Project (https://pixabay.com/music/suspense-darkness-approaching-cinematic-danger-407228/)"Space Discovery" by The_Mountain (https://pixabay.com/music/pulses-space-discovery-179468/)"Time For Something New" by Music_for_Creators (https://pixabay.com/music/modern-classical-time-for-something-new-136901/)"Sad Sorrowful Funeral Music" by HitsLab (https://pixabay.com/music/funerals-sad-sorrowful-funeral-music-413644/)"Electronic Tension" by leberch (https://pixabay.com/music/mystery-electronic-tension-255438/)"Ambient Space Arpeggio" by Universfield (https://pixabay.com/music/ambient-ambient-space-arpeggio-350710/)No Quest for the Wicked uses trademarks and/or copyrights owned by Paizo Inc., used under Paizo's Community Use Policy (paizo.com/communityuse). We are expressly prohibited from charging you to use or access this content. No Quest for the Wicked is not published, endorsed, or specifically approved by Paizo. For more information about Paizo Inc. and Paizo products, visit paizo.com. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Today we have another Pulm PEEPs Pearls episode about a core critical care topic. Furf and Monty will be giving a high level overview of the use of steroids in sepsis including a review of the relevant literature and recent guidelines, and pragmatic bedside points. Contributors This episode was prepared with research by Pulm PEEPs Associate Editor George Doumat. Dustin Latimer, another Pulm PEEPs Associate Editor, assisted with audio and video editing. Key Learning Points Why Steroids in Sepsis? Steroids do not treat the infection — antimicrobials are always first and remain the cornerstone. The goal is addressing critical illness–related corticosteroid insufficiency (CIRCI), where cortisol production cannot keep up with the overwhelming inflammatory demand of septic shock. Hydrocortisone helps in two main ways: Blunts the dysregulated inflammatory response — tempers the excessive vasodilation and febrile response that drive harm beyond the infection itself. Restores vascular sensitivity to catecholamines — sepsis downregulates adrenergic receptors; steroids turn that responsiveness back on. Clinical takeaway: The first thing you notice is vasopressor weaning (or a bend in the escalation curve) — not a rapid improvement in fever or white count. Caveat: These trials predate modern sepsis phenotyping. None distinguish hyperinflammatory vs. hypoinflammatory responders — they treat all comers. The Evidence: Four Landmark Trials Every IM resident and critical care fellow will eventually journal-club these four. The most consistent signal across all of them is faster shock reversal and reduced vasopressor use; the mortality question remains unsettled. Trial (Year)NRegimenKey FindingAnnane (2002)~300Hydrocortisone + fludrocortisoneMortality benefit in ACTH non-responders; criticized methodology and messy cortisol-response testing; not cleanly replicated.CORTICUS (2008)~500Hydrocortisone aloneFaster shock reversal but no mortality benefit, regardless of cortisol responsiveness. Raised (later allayed) superinfection concern. Cornerstone for abandoning routine cort-stim testing.ADRENAL (2018)~3,800Hydrocortisone aloneFaster vasopressor weaning; no 90-day mortality benefit.APROCCHSS (2018)~1,200Hydrocortisone + fludrocortisoneMortality benefit at 90 days. Bottom line: Faster shock reversal is consistent. Mortality benefit appears in 2 of 4 trials (both used fludrocortisone) but not the others. A 2026 meta-analysis showed benefit for hydrocortisone + fludrocortisone vs. placebo, but not for hydrocortisone + fludrocortisone vs. hydrocortisone alone — suggesting hydrocortisone drives the main effect. Who Gets Steroids, and When? 2021 Surviving Sepsis: Consider steroids for norepinephrine or epinephrine ≥ 0.25 mcg/kg/min for ≥ 4 hours despite adequate resuscitation — a reasonable bedside trigger. Early 2026 update: Moved away from a specific numeric trigger — consider steroids when a septic patient is not responding well to vasopressors or has escalating requirements. Make a clinical decision. (Quality of evidence: low to moderate.) Go faster than the threshold when: Known/suspected adrenal insufficiency or home steroids, or florid pressor-requiring shock on arrival. A practical escalation sequence: escalating norepinephrine → add vasopressin (per VASST) → then add steroids if requirements keep climbing. Do NOT wait for an ACTH stimulation test. It does not reliably predict who responds and only delays treatment. Sepsis is an elevated-cortisol state but can dissociate ACTH and cortisol, and cortisol-binding globulin is depleted — the test is too messy to guide care. What to Give: The Regimen Standard dose: Hydrocortisone 200 mg/day, typically 50 mg IV Q6H. (Original trials often used continuous infusions, rarely used in the U.S.) Some start with a 100 mg bolus to gain control. Higher dose: If chronically on steroids / adrenally insufficient, consider ~300 mg/day (e.g., 100 mg Q8H). Fludrocortisone: Unsettled. The two mortality-benefit trials added it (50 mcg PO/NG/OG daily), but hydrocortisone already has mineralocorticoid activity and meta-analyses don't show added benefit over hydrocortisone alone. Most clinicians omit it — adding it is reasonable and safe, just be honest about the uncertainty. Duration & Tapering Typical course: ~7 days is most common. Trial practices varied (ADRENAL ~7 days; VANISH used a taper after 6 days; some continue until pressors are off). No taper needed. You do not need to taper for adrenal insufficiency after a short course — just stop. If pressors dramatically rebound, you can restart, but most patients have gained the benefit they'll get by day 7. Pitfalls & Safety Hyperglycemia: Expected and must be managed (monitor closely; insulin drip if needed). No signal for major DKA / severe complications in the trials. Superinfection / fungal infection: The most-quoted concern, but the overall literature does not show a convincing, statistically significant increase. Be disciplined about stopping on schedule. Muscle weakness: Steroids can worsen critical illness myopathy; a short 7-day course likely has limited effect, but be aware. Other: GI bleeding (follow general PPI prophylaxis guidance) and sodium disturbances (watch for hyper-/hyponatremia). Two things we know: (1) steroids shorten duration of vasopressor support, and (2) they are relatively safe in sepsis. Whether they improve mortality — and in whom — remains open. The Five Pulm PEEPs Pearls Mechanism: Steroids restore catecholamine vascular sensitivity and blunt dysregulated inflammation. The clinical target is vasopressor weaning, not infection treatment. Evidence: Faster shock reversal is the most consistent finding. Mortality benefit is seen in 2 of 4 trials but not the others — still controversial. Some patients likely benefit; we don't yet know who. Trigger: A practical 2021 threshold is levo/epi ≥ 0.25 mcg/kg/min for ≥ 4 hours. Newer guidance drops the strict number — make a clinical decision based on poor pressor response or escalation. Dose: Hydrocortisone 200 mg/day (e.g., 50 mg Q6H). Adding fludrocortisone mirrors two trials, but meta-analyses find no benefit over hydrocortisone alone. Safety: Steroids appear safe in sepsis. Monitor and treat hyperglycemia; no marked increase in superinfection. References and Further Reading Annane, Djillali et al. “Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock.” JAMA vol. 288,7 (2002): 862-71. doi:10.1001/jama.288.7.862 Sprung, Charles L et al. “Hydrocortisone therapy for patients with septic shock.” The New England journal of medicine vol. 358,2 (2008): 111-24. doi:10.1056/NEJMoa071366 Venkatesh, Balasubramanian et al. “Adjunctive Glucocorticoid Therapy in Patients with Septic Shock.” The New England journal of medicine vol. 378,9 (2018): 797-808. doi:10.1056/NEJMoa1705835 Annane, Djillali et al. “Hydrocortisone plus Fludrocortisone for Adults with Septic Shock.” The New England journal of medicine vol. 378,9 (2018): 809-818. doi:10.1056/NEJMoa1705716 Sun, Alin et al. “Correction: Hydrocortisone combined with fludrocortisone for treatment of adults with septic shock: an updated meta-analysis and systematic review.” Frontiers in medicine vol. 13 1811616. 2 Mar. 2026, doi:10.3389/fmed.2026.1811616 Prescott, Hallie C et al. “Executive Summary: Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026.” Critical care medicine vol. 54,4 (2026): 715-724. doi:10.1097/CCM.0000000000007089

If you enjoy this episode, we're sure you will enjoy more content like this on The Occult Rejects.  In fact, we have curated playlists on occult topics like grimoires, esoteric concepts and phenomena, occult history, analyzing true crime and cults with an occult lens, Para politics, and occultism in music. Whether you enjoy consuming your content visually or via audio, we've got you covered - and it will always be provided free of charge.  So, if you enjoy what we do and want to support our work of providing accessible, free content on various platforms, please consider making a donation to the links provided below.  Thank you and enjoy the episode!Links For The Occult Rejectshttps://linktr.ee/theoccultrejectsOccult Research Institutehttps://www.occultresearchinstitute.org/Substackhttps://substack.com/@theoccultrejects?r=7auau0&utm_campaign=profile&utm_medium=profile-pageCash Apphttps://cash.app/$theoccultrejectsVenmo@TheOccultRejectsBuy Me A Coffeebuymeacoffee.com/TheOccultRejectsPatreonhttps://www.patreon.com/TheOccultRejectsBiblioBernardi, Luciano, Peter Sleight, Gabriele Bandinelli, Simone Cencetti, Luciano Fattorini, Johanna Wdowczyc-Szulc, and Alfonso Lagi. “Effect of Rosary Prayer and Yoga Mantras on Autonomic Cardiovascular Rhythms: Comparative Study.” BMJ 323, no. 7327 (2001): 1446–1449.Benson, Herbert, John W. Lehmann, Mark S. Malhotra, Ralph F. Goldman, Jeffrey Hopkins, and Mark D. Epstein. “Body Temperature Changes During the Practice of g Tum-mo Yoga.” Nature 295 (1982): 234–236.Benson, Herbert, Mark S. Malhotra, Ralph F. Goldman, Gregory D. Jacobs, and Jeffrey Hopkins. “Three Case Reports of the Metabolic and Electroencephalographic Changes During Advanced Buddhist Meditation Techniques.” Behavioral Medicine 16, no. 2 (1990): 90–95.Bremer, Brandon, Lorenzo Wu, Zoran Josipovic, and colleagues. “Mindfulness Meditation Increases Default Mode, Salience, and Central Executive Network Connectivity.” Scientific Reports 12 (2022).Brewer, Judson A., Patrick D. Worhunsky, Jeremy R. Gray, Yi-Yuan Tang, Jochen Weber, and Hedy Kober. “Meditation Experience Is Associated with Differences in Default Mode Network Activity and Connectivity.” Proceedings of the National Academy of Sciences 108, no. 50 (2011): 20254–20259.Britton, Willoughby B. and colleagues. Research associated with the “Varieties of Contemplative Experience” project on meditation-related challenges, adverse effects, and safety considerations in contemplative practice.Crowley, Aleister. Liber E vel Exercitiorum sub figura IX. In the A∴A∴ training corpus. Relevant sections include asana, pranayama, and dharana as foundational magical exercises.Dennison, Paul. “Insights From an EEG Study of Buddhist Jhāna Meditation.” Frontiers in Human Neuroscience 13 (2019).Fialoke, Shantala, Helen Weng, and colleagues. “Functional Connectivity Changes in Meditators and Novices During Yoga Nidra Practice.” Scientific Reports 14 (2024).Fox, Kieran C. R., Savannah Nijeboer, Matthew L. Dixon, James L. Floman, Melissa Ellamil, Samuel P. Rumak, Peter Sedlmeier, and Kalina Christoff. “Is Meditation Associated with Altered Brain Structure? A Systematic Review and Meta-analysis of Morphometric Neuroimaging in Meditation Practitioners.” Neuroscience & Biobehavioral Reviews 43 (2014): 48–73.Hölzel, Britta K., James Carmody, Mark Vangel, Christina Congleton, Sita M. Yerramsetti, Tim Gard, and Sara W. Lazar. “Mindfulness Practice Leads to Increases in Regional Brain Gray Matter Density.” Psychiatry Research: Neuroimaging 191, no. 1 (2011): 36–43.Kozhevnikov, Maria, Olesya Louchakova, Zoran Josipovic, and Michael A. Motes. “The Enhancement of Visuospatial Processing Efficiency Through Buddhist Deity Meditation.” Psychological Science 20, no. 5 (2009): 645–653.Kozhevnikov, Maria, John A. Elliott, Jennifer Shephard, and Klaus Gramann. “Neurocognitive and Somatic Components of Temperature Increases During g-Tummo Meditation: Legend and Reality.” PLOS ONE 8, no. 3 (2013): e58244.Laukkonen, Ruben E., and Heleen A. Slagter. “From Many to (N)one: Meditation and the Plasticity of the Predictive Mind.” Neuroscience & Biobehavioral Reviews 128 (2021): 199–217.Lomas, Tim, Juan Carlos Ivtzan, and Itai K. Fu. “A Systematic Review of the Neurophysiology of Mindfulness on EEG Oscillations.” Neuroscience & Biobehavioral Reviews 57 (2015): 401–410.Lott, James P., Richard J. Davidson, John D. Dunne, Thupten Jinpa, Antoine Lutz, and colleagues. “No Detectable Electroencephalographic Activity After Clinical Declaration of Death Among Tibetan Buddhist Meditators in Apparent Tukdam.” Frontiers in Psychology 11 (2021): 599190.Lutz, Antoine, Lawrence L. Greischar, Nancy B. Rawlings, Matthieu Ricard, and Richard J. Davidson. “Long-term Meditators Self-induce High-amplitude Gamma Synchrony During Mental Practice.” Proceedings of the National Academy of Sciences 101, no. 46 (2004): 16369–16373.Lutz, Antoine, Julie Brefczynski-Lewis, Tom Johnstone, and Richard J. Davidson. “Regulation of the Neural Circuitry of Emotion by Compassion Meditation: Effects of Meditative Expertise.” PLoS ONE 3, no. 3 (2008): e1897.Matko, Karin, Peter Sedlmeier, and colleagues. “Adverse Effects of Meditation and Mindfulness in Clinical Practice.” 2025.Patanjali. Yoga Sutras. Especially Book III, traditionally describing dharana, dhyana, and samadhi.Riegner, Gretchen, Fadel Zeidan, and colleagues. “Disentangling Self from Pain: Mindfulness Meditation-Induced Pain Relief Is Driven by Thalamic-Default Mode Network Decoupling.” Pain 164, no. 2 (2023): 280–291.Tang, Yi-Yuan, Britta K. Hölzel, and Michael I. Posner. “The Neuroscience of Mindfulness Meditation.” Nature Reviews Neuroscience 16 (2015): 213–225.Vago, David R., and David A. Silbersweig. “Self-awareness, Self-regulation, and Self-transcendence: A Framework for Understanding the Neurobiological Mechanisms of Mindfulness.” Frontiers in Human Neuroscience 6 (2012): 296.Zeidan, Fadel, and colleagues. Research on mindfulness meditation, pain modulation, attention, and the neural mechanisms of pain relief.Slagter, Heleen A., Antoine Lutz, Lawrence L. Greischar, Andrew D. Francis, Sander Nieuwenhuis, James M. Davis, and Richard J. Davidson. “Mental Training Affects Distribution of Limited Brain Resources.” PLOS Biology 5, no. 6 (2007): e138. Use for: Attentional blink, limited attention, and meditation changing how the brain allocates resources.Hölzel, Britta K., James Carmody, Mark Vangel, Christina Congleton, Sita M. Yerramsetti, Tim Gard, and Sara W. Lazar. “Mindfulness Practice Leads to Increases in Regional Brain Gray Matter Density.” Psychiatry Research: Neuroimaging 191, no. 1 (2011): 36–43. Use for: Neuroplasticity, repeated practice leaving measurable marks on the brain, and the “practice writes itself into the practitioner” idea.Laukkonen, Ruben E., and Heleen A. Slagter. “From Many to (N)one: Meditation and the Plasticity of the Predictive Mind.” Neuroscience & Biobehavioral Reviews 128 (2021): 199–217. Use for: Predictive processing, the brain as a prediction machine, meditation loosening automatic models, and the “veil” argument.Lutz, Antoine, Julie Brefczynski-Lewis, Tom Johnstone, and Richard J. Davidson. “Regulation of the Neural Circuitry of Emotion by Compassion Meditation: Effects of Meditative Expertise.” PLOS ONE 3, no. 3 (2008): e1897. Use for: Compassion meditation, loving-kindness, emotional circuitry, and training compassion as a repeatable state rather than just a moral idea.Kok, Bethany E., Kimberly A. Coffey, Michael A. Cohn, Lahnna I. Catalino, Tanya Vacharkulksemsuk, Sara B. Algoe, Marc A. Brantley, and Barbara L. Fredrickson. “How Positive Emotions Build Physical Health: Perceived Positive Social Connections Account for the Upward Spiral Between Positive Emotions and Vagal Tone.” Psychological Science 24, no. 7 (2013): 1123–1132. Use for: Loving-kindness, social connection, vagal tone, and the cautious “social nervous system” bridge.Black, David S., and George M. Slavich. “Mindfulness Meditation and the Immune System: A Systematic Review of Randomized Controlled Trials.” Annals of the New York Academy of Sciences 1373, no. 1 (2016): 13–24. Use for: Immune-system caution, inflammation markers, cell-mediated immunity, biological aging, and why this material should be framed as tentative rather than miracle healing.Burić, Ivana, Miguel Farias, Jonathan Jong, Christopher Mee, and Inti A. Brazil. “What Is the Molecular Signature of Mind–Body Interventions? A Systematic Review of Gene Expression Changes Induced by Meditation and Related Practices.” Frontiers in Immunology 8 (2017): 670. Use for: Stress biology, inflammatory gene expression, NF-kB-related language, and the cautious claim that mind-body practices may affect biology below ordinary mood.Also want to remind people about the website, if you're into reading we have tons of information by multiple contributors, and we got t-shirts up on the site if you're interested. Fun fact, the art is all based on the eyeball. A

Deb 00:00:01Imagine your body has a repair manual, instructions written in your cells that tell tissues how to heal, blood vessels, how to grow, and inflammation when to stop. But what if those instructions got lost somewhere along the way? Well, today I’m talking about peptides, tiny protein fragments that act like biological text messages. Two of them, BPC 157 and TB 500.They’re showing remarkable promise for gut repair, joint recovery, and tissue regeneration. But here’s what nobody’s telling you. Women respond differently to these healing signals, especially during hormonal transitions. And today, we’re uncovering the science behind these regenerative peptides, who actually needs them, and why your doctor might not know about them. Can you guys put our ad right in here and then I’ll go to the standard intro?Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, explore cutting edge regenerative medicine, and empower you with the tools to heal. I’m Dr. Deb, your medical detective. And today we’re diving into regenerative peptides BPC157 and TB 500. If you or someone you love is struggling with slow recovery from injury, chronic joint pain, gut inflammation that just won’t quit, or you just feel like your body doesn’t bounce back the way it used to, this episode is for you. Grab a cup of coffee or tea or whatever helps you unwind, settle in, and let’s start you on your journey to deeper healing. We’ll do another sponsor break here. Deb 00:01:52So let’s start with the question I hear constantly in my practice. Dr. Deb, I’m doing everything right. I’m eating clean, I’m exercising, I’m taking my supplements, but I’m still not healing. What am I missing? Well, that answer might surprise you. Sometimes it’s not about what you’re putting in your body. It’s about whether your cells are actually receiving the repair signals they need. That’s where peptides come in. Think of peptides as The body’s original communication system. These short chains of amino acids are like biological post-it notes carrying instructions from one cell to another. They tell your human system when to calm down, your blood vessels when to grow and your tissues when to repair. Now here’s where it gets interesting for women specifically. We know that estrogen plays a massive role in collagen production, vascular health, inflammatory response. When estrogen starts declining, whether that’s perimenopause, postpartum, or even from chronic stress, our natural repair mechanisms slow down dramatically. You might notice it as my joints are aching more, I’m a little more fluid filled, you know, they hurt when I bend them, my injuries take twice as long to heal.Gut issues that suddenly appear out of nowhere and no matter what you do, they don’t seem to repair. Skin has lost its elasticity or just this general sense that your body isn’t keeping up anymore. This is where BPC 157 and TB 500 entered the picture. So BPC 157, short for body protection compound 157, is a naturally occurring peptide sequence found in your gastric juices. And according to a 2024 systemic review published in emerging use of BPC 157 in orthopedic sports medicine, this peptide promotes something called angiogenesis. That’s the formation of new blood vessels and they deliver oxygen and nutrients to damaged tissues. Now TB 500 is a synthetic fragment of thymus and beta-4. Deb 00:04:17A protein your body makes naturally during wound healing and research published in therapeutic peptides in orthopedics in 2025 shows that it works like a cellular first responder rushing to injury sites and coordinating tissue repair through a process called actin regulation. But here’s what makes these peptides different from just taking another supplement. They don’t force your body to do anything.They simply remind yourselves how to heal the way they used to. And for women navigating hormonal changes, autoimmune flares, chronic inflammatory conditions, that distinction matters enormously. all right, let’s get into some of these mechanisms because understanding how something works helps you make informed decisions about whether or not it’s right for you. So,Let’s look at the science. Do these peptides actually work? And if so, how do they work? Let’s start with BPC 157. This works through multiple pathways simultaneously. First, it activates growth factor receptors that stimulate fibroblasts. Those are the cells responsible for making collagen and rebuilding connective tissue. And according to research published in Frontiers and Pharmacology in 2023, titled Regeneration or Risk, BPC 157 also modulates nitric oxide signaling, which enhances vascular repair and reduces oxidative stress at the cellular level. So this is really important because many of us are nitric oxide deficient, especially as we get older, especially since the pandemic, we’re seeing a lot of people being more deficient in nitric oxide and you’re taking nitric oxide, many of you, to help with this process. But if we’re having other issues that don’t allow that nitric oxide to get where it needs to go, that could render it completely useless. So in plain English, when we’re talking about how BPC 157 helps the blood vessels work better and protects your mitochondria, big word for your energy factories and your cells from that inflammatory damage. Deb 00:06:38Now there’s studies in musculoskeletal and gastroenterology models that show BPC157 decreases inflammatory cytokines like TNF-alpha and IL-6. And these are chemical messengers that keep inflammation turned on. So by dialing them down, BPC157 creates an environment where healing can actually happen. Now, where do we know about this?TNFL and IL-6, well, we know it from viruses, we know it from Lyme disease, we know it from mold toxicity. These cytokines are turned up, they’re creating a massive inflammatory response in the body, and you’re struggling to get these things down because of that or potentially other reasons. So here’s where it gets really interesting with women in perimenopause or menopause. When estrogen declines, collagen synthesis slows down. And that’s why we see increased joint pain, slower wound healing, and our changes in the skin’s elasticity during this transition. We see the little wrinkles, the fine lines, we see the subcutaneous fat going away a little bit more. This is partially why this is occurring. And so from research shown in the Journal of Orthopedic Research in 2023 by Leibowitz and colleagues, that they suggest that BPC157 affects on the endothelial layers. So the cells lining the blood vessels and these may mimic some of the estrogen’s protective vascular effects without actually affecting your hormone levels. This is really huge because we know that as women lose estrogen, they have a higher risk for vascular events, heart attack, stroke, things like that. And if people have already had a heart attack or a stroke, We typically recommend that they don’t use estrogen because that could potentiate the risk for another heart attack or a stroke. But that means that you don’t gain the benefits of estrogen either. So if we think about this, we could potentially use BPC 157 to give us some of the benefits that we lost from having estrogen and potentially not being able to use estrogen. And that would be huge for us. Deb 00:08:57And not to mention the reduction of inflammation and the joint pain and the wound healing and the energy and the gut feelings. I mean, there’s just so many benefits to BPC 157 that we could talk about them all day long. But we’ve got to move on. So let’s talk about TB 500. Now this peptide works very differently. Its primary job is promoting cell migration, essentially telling repair cells to go to this spot and what to do when they get there. So it sends a signal, puts a little post-it stamp there and says, Hey, when you get there, fix A, B, C, and D. And there was a study in 2024 in cell biology international that demonstrated that TB 500 increases epithelial closure and improves tendon elasticity in models of repetitive strain injury. So let’s think about that a little bit. What does that really mean?That means faster recovery from exercise induced muscle damage, better healing of overuse injuries like tennis elbow or plantar fasciitis, improved scar tissue remodeling after surgery or a C-section, enhanced recovery from chronic inflammatory conditions affecting soft tissues. And I’ve talked about this several times. I have used these compounds post-surgical personally.And I remember going back to see my surgeon at the two to three week mark for follow-up. And she was amazed at how well everything was healing. And when I asked her if she wanted to know what I was doing, her response was no, but keep doing whatever you’re doing because it’s working. And after three weeks of a major pelvic repair surgery that I had, four hours in surgery, lots of sutures, not comfortable. I was actually walking a mile and didn’t have pain and I was recovering really well and felt amazing. And that is just not typically heard of in surgical procedures like mine. It’s usually a minimum of a six to eight week recovery before you’re starting to do that again. And I give all of the credit to these two peptides. Deb 00:11:17In my clinical practice, I see this play out constantly. Women who train hard, whether that’s CrossFit, running, yoga, or just trying to keep up with active kids, often hit a wall where their recovery can’t keep up pace with their activity level. And TB 500 helps to bridge that gap by optimizing the body’s natural repair timeline. But here’s what I want to emphasize with you. These peptides aren’t magic bullets.They work best when we combine them with proper nutrition and anti-inflammatory diet, adequate sleep, stress management, and we address the underlying root cause like the gut dysfunction or those hormonal imbalances. And they work much better when the hormones are balanced versus when they’re not. They’re amplifiers of your body’s existing healing capacity, not replacements for foundational health practices.So let’s have some real talk here. Let’s talk about evidence and what you need to know about that. Let’s take a drink, sorry. Now let’s address the elephant in the room. Regulatory status and safety. Neither BPC 157 or TB 500 are FDA approved for human medical use. They fall into a category called research compounds. And that means they’re legal to possess and use but they’re not approved as pharmaceutical drugs. And hopefully they will be back on our list of things to use relatively soon with the changes that Bobby Kennedy has made to peptides recently. So why does this matter? Because quality becomes a concern. Quality control is absolutely critical. You need to know where these compounds are manufactured, their source, their testing. their clarity, everything about them. There was a 2025 review in therapeutic peptides in orthopedics that concluded both peptides demonstrate strong regenerative signaling with minimal systemic side effects in preclinical studies. But, and this is really important, most of the robust data we have comes from animal models and cell culture models, not large scale human clinical trials. Deb 00:13:41Now that doesn’t mean that they don’t work. It just means that we are still in the early stages of understanding optimal dosing, treatment duration, and long-term effects in humans. So why do we have all of this great peptide information and we don’t quite have the ability to use them yet, or it’s extremely restricted?That comes under the guise of the FDA. came through the past administration with Biden where he removed a bunch of these peptides from the market. Both BPC and TB 500 were on the list of safe peptides to use before Biden made his changes. And it looks like they may be coming back relatively quickly for us here. So what we do have is growing clinical feedback from practitioners like myself. Who use these peptides in practice under careful supervision and under pilot studies on musculoskeletal recovery published in our organizations that we work with. So all of our information is documented and it is done under an observational study. There are other studies published in orthopedic and biomedical research from 2025.that actually found VPC-157 reduced pain scores by 35 % and improved functional mobility within eight weeks. This is really phenomenal because many people over the age of 40 are reaching for the Tylenol bottle, the Advil bottle, the Aleve bottle, which does a number on your kidneys and your gut and your liver. And it is really problematic to be using these things on a regular basis.And if we can use a compound that’s safe, that preserves the kidneys, the liver and the gut, why don’t we do that is the question that I have. Now, we see a lot of the same information in our clinic that we see in these studies. And it is the following things that we see. Significant reduction in joint pain and stiffness. I have a person that was looking at doing a knee replacement and we did 10 weeks of these two compounds. Deb 00:16:00And her knee pain reduced so much that she decided she didn’t feel like she needed that knee replacement right away, which is good because she is only 60 years old. And the length of that knee replacement wouldn’t be as long as it would if she could wait five or 10 years. The doctor didn’t say she needed to do it right away. She wasn’t that critical, but it was the pain that was driving her to the replacement. And so if we could preserve that and give her a reduction in pain, all the better to do that. We get faster recovery from surgical procedures, improved gut symptoms, especially in cases of leaky gut or inflammatory bowel conditions, better skin quality and wound healing, enhanced overall sense of resilience and recovery capacity. But here’s what you absolutely must know before considering peptide therapy. First, source matters. Because these aren’t FDA regulated pharmaceuticals, quality varies widely and you need to work with a physician who sources from compounding pharmacies 503A or 503B that provide certificates of analysis, third party testing and proper sterility verification. Secondly, context matters. Peptides work best as part of a comprehensive functional medicine approach. So if you’re still eating inflammatory foods, drinking alcohol, not managing your stress or your sleep, you have unaddressed gut dysfunction, and these peptides alone won’t fix those problems. Thirdly, realistic expectations matter. These aren’t overnight miracle cures. Most patients see gradual improvements over four to 12 weeks. Some respond dramatically, others see modest benefits. Individual variation is real. And fourth, medical supervision matters. Dosing, injection technique,monitoring for side effects and knowing when peptides are or are not appropriate. All of this requires clinical expertise. Now let me bust a few myths here because I hear this constantly. Myth number one, peptides are just for bodybuilders and athletes. That is false. While athletes use them for performance recovery, the therapeutic applications for chronic pain, gut healing and age related tissue decline are profound. Deb 00:18:26For everyday people. Myth number two, peptides will mess with my hormones. False. BPC-157 and TB-500 don’t interact with your endocrine system the way hormones do. They work through growth factors and cell signaling pathways. They are very different. Myth number three, if they’re not FDA approved, they must be dangerous. Not accurate.Many effective therapies exist in regulatory gray zones. What matters is quality sourcing, proper medical oversight, and informed consent. So the bottom line here is that these peptides show real promise backed by mechanistic science and growing clinical expertise, but they require responsible use, quality products, and realistic expectations. Now let’s talk about practical integration.Who should consider peptides? Well, so who actually benefits from the peptides? Let’s start there. Let me walk you through the three main categories I see. Number one is gut restoration. If you’re dealing with chronic gut inflammation, whether that’s IBS, inflammatory bowel disease, leaky gut, persistent digestive issues that haven’t responded to dietary changes alone, BPC 157 can be transformative.I had a patient recently, I’ll call her Sarah. She’s been struggling with severe gut pain and food sensitivities for three years. She tried elimination diets, probiotics, gut healing supplements, everything. And within six weeks of adding BPC 157 to her protocol, alongside the targeted nutritional therapy, her pain dropped by 70 % and she could tolerate foods that she hadn’t tolerated in years. Why does this happen? because BPC 157 directly supports mucosal integrity, the protective lining of your intestinal tract, and it reduces inflammatory cytokines and promotes healing of damaged tissue. Number two, muscle and joint recovery. This is where I see TB 500 shine. Women who are active, whether you’re a runner, a yogi, a cross-bitter, or someone who just wants to keep moving without pain. Deb 00:20:48They often hit a point where recovery becomes a very limiting factor. And maybe you’re dealing with chronic tendonitis, a nagging shoulder injury, a bad back that just will not quit, or just general achiness. It all makes you feel older and keeps you from being active the way you want to. TB 500 combined with therapies like red light therapy, PEMF, or targeted physical therapy, can dramatically accelerate soft tissue healing. I’ve seen recovery timelines cut in half for patients dealing with overuse injuries. Number three, menopausal transition support. This is where the intersection of peptides in women’s health gets really exciting. During perimenopause and menopause, declining estrogen affects collagen production, vascular health, and joint integrity, along with inflammatory processes and responses.Many women notice they just don’t heal as quickly and their joints hurt much more. Besides noticing their skin changes and their injuries linger longer. Low dose peptide protocols, often combining BPC157 for vascular and gut support with TB500 for soft tissue repair, can complement bioidentical hormone therapy or stand alone for women who can’t or don’t want to use hormones.Now I’m not saying that peptides replace your hormone optimization, but they can be powerful adjuncts that support tissue resilience during a time when your body’s natural repair mechanisms are shifting. Now, who should not use peptides? If you have any active cancer or a history of certain cancers, peptides that promote cell growth and angiogenesis might not be appropriate. If you’re pregnant or breastfeeding, we don’t have safety data.If you have severe kidney or liver disease, clearance and metabolism could be affected. You want to work with a practitioner who really understands this and be under medical supervision for these kinds of conditions. This really matters. A qualified functional medicine practitioner can assess your individual situation, run appropriate labs and determine whether peptides fit into your overall healing strategy. Remember, peptides are tools. They’re not magic. Deb 00:23:11They work best when you’re also addressing nutrition, sleep, stress, movement, and underlying root causes. They amplify your body’s healing capacity. They don’t replace the fundamentals. This is really important to understand. So thank you for joining me today on Let’s Talk Wellness Now. If this episode resonated with you, share it with another woman who’s ready to reclaim her body’s natural healing capacity. Remember, Wellness isn’t just about feeling good. It’s about thriving in every area of your life. Your body was designed to heal. You’re not a small version of a male. You are a woman with different biochemistry. And sometimes it just needs the right signals and the right support to remember how. If you’re ready to explore personalized regenerative medicine or peptide therapy as part of a comprehensive functional medicine approach,You can visit us at serenityhealthcarecenter.com. You can also follow us on Instagram, and you can look at my book, Seen at Last, and join the Seen at Last free community on Facebook, where we will provide all of this information and more for you. Until next time, I’m Dr. Deb, reminding you to take care of your body, mind, and spirit. Be well, and I’ll see you in the next episode.The post Episode 269 – Peptide Therapy for Women: How BPC-157 & TB-500 Heal Gut, Joints & Inflammation first appeared on Let's Talk Wellness Now.

Could you have metabolic dysfunction even at a normal weight?This episode challenges everything we've been taught about weight and health. Dr. Cooper reveals that up to 25% of normal-weight people have metabolic syndrome, yet they're rarely screened because doctors assume they're healthy based on appearance alone.KEY TAKEAWAYSWeight and metabolic health are not the same thing - you can be metabolically unhealthy at any sizeNormal weight people with metabolic dysfunction are often overlooked and undertreated by healthcare providersKey screening tests include fasting glucose, insulin, HbA1c, triglycerides, HDL cholesterol, blood pressure, and inflammatory markers like HSCRPMetabolic dysfunction can start in your 20s and take decades to develop into serious diseaseBoth normal weight and higher weight patients face bias - normal weight people aren't screened enough, while higher weight people have everything blamed on their weightEarly screening and treatment can prevent catastrophic health outcomes later in lifeThe liver plays a crucial role in metabolism and can become insulin resistant regardless of body weightNOTABLE QUOTE"You cannot tell anything about someone's health from their outside, what they look like or what, even what they're doing necessarily, but definitely not their body size. So you can be healthy or unhealthy at any size body, and I think that's what's overlooked quite a bit." — Dr. Emily CooperLinks & ResourcesPodcast Home: fatsciencepodcast.comCooper Center for Metabolism: coopermetabolic.comResources from Dr. Cooper: coopermetabolic.com/resourcesJoin Our Community: patreon.com/cw/FatSciencePodcastSubmit Your Question: questions@fatsciencepodcast.com or dr.c@fatsciencepodcast.comAppendix: Key ReferencesPrimary literature supporting this episode•       Wang et al. Prevalence of Metabolically Unhealthy Normal Weight and Its Influence on the Risk of Diabetes. Journal of Clinical Endocrinology & Metabolism, 2023.•       Review: Beyond BMI — Rethinking Obesity Metrics and Cardiovascular Risk in the Era of Precision Medicine. Journal of Clinical Medicine, December 2025.•       Korean meta-analyses on metabolic dysfunction phenotypes and cardiometabolic risk, Cardiovascular and Metabolic Sciences Journal review, 2024.•       Frontiers in Nutrition, January 2026. Associations of metabolic heterogeneity with the progression of cardiometabolic multimorbidity.•       International Journal of Obesity, September 2025. Cardiovascular risk factors associated with metabolic health phenotypes.Mechanism references•       MASLD — metabolic dysfunction-associated steatotic liver disease — nomenclature and clinical framework. AASLD/EASL consensus, 2023.•       Insulin signaling, adipose tissue dysfunction, and ectopic fat deposition — reviews on the upstream-downstream relationship.•       Epicardial adipose tissue and cardiovascular dysfunction — Frontiers in Cardiovascular Medicine, January 2026.Fat Science is supported by the Diabesity Institute, a nonprofit dedicated to increasing access to effective, science-based metabolic care.This podcast is for informational purposes only and is not intended as medical advice. Please consult with a qualified healthcare provider for personalized recommendations.

On the night of May 23 to 24, Russia destroyed the apartment of our author Artem Zakharchenko. Fortunately, Artem and his wife were not injured. But they were left without a home. Could you please share this information with the activist communities in your countries? This family now needs support to rebuild their home and their life from scratch.PayPal of the oldest son, Marco: limark.2mark@gmail.com name: Marko ZakharchenkoFor Ukrainian banking: Посилання на банкуhttps://send.monobank.ua/jar/7sFs5B5MAiНомер картки банки - 4874 1000 3826 9596----------Artem Zakharchenko is a Ukrainian writer, journalist, editor, media analyst and scholar from Kyiv, originally from Chernihiv. He holds a doctorate in social communications and is associated with the Institute of Journalism at Taras Shevchenko National University of Kyiv and is head of CAT-UA. His work spans two connected fields: Ukrainian literature and information warfare / strategic narratives. As a novelist, he is the author of Помру за Україну, але це не точно — roughly, I'll Die for Ukraine, But Not for Sure — a 2021 contemporary Ukrainian novel about imprisonment, patriotism, betrayal and the moral costs of war. As a communications researcher, he writes on Russian propaganda, social media, Ukrainian wartime narratives and the struggle for attention in the information space. His 2025 Frontiers article develops the idea of a “connective strategic narrative” in the Russian-Ukrainian war: a narrative formed not only by state elites, but by emotionally engaged social media public. ----------BOOKS: Narratives of Mass Destruction: Tactics and Strategies of Information Warfare (2026)Наративи масового ураження. Тактики і стратегії інформаційної війниПомру за Україну, але це не точноI'll Die for Ukraine, But Not for Sure (2021)----------LINKS:https://www.lemonde.fr/en/international/article/2024/04/18/ukrainian-authorities-are-worried-about-online-disinformation_6668838_4.htmlhttps://internews.ua/en/opportunity/social-cleavages-in-ukraine----------SUPPORT THE CHANNEL:https://www.buymeacoffee.com/siliconcurtainhttps://www.patreon.com/siliconcurtainhttps://www.gofundme.com/f/scaling-up-campaign-to-fight-authoritarian-disinformation----------TRUSTED CHARITIES ON THE GROUND:Car4Ukrainehttps://car4ukraine.com/en-US/campaignsDzyga's Pawhttps://dzygaspaw.com/projectsSuperhumans - Hospital for war traumashttps://superhumans.com/en/UNBROKEN - Treatment. Prosthesis. Rehabilitation for Ukrainians in Ukrainehttps://unbroken.org.ua/Come Back Alivehttps://savelife.in.ua/en/Chefs For Ukraine - World Central Kitchenhttps://wck.org/relief/activation-chefs-for-ukraineUNITED24 - An initiative of President Zelenskyyhttps://u24.gov.ua/Serhiy Prytula Charity Foundationhttps://prytulafoundation.orgNGO “Herojam Slava”https://heroiamslava.org/----------PLATFORMS:Substack: https://substack.com/@siliconcurtainTwitter: https://twitter.com/CurtainSiliconLinkedin: https://www.linkedin.com/in/finkjonathan/Podcast: https://open.spotify.com/show/4thRZj6NO7y93zG11JMtqm----------

Today we have Dr. Dominic D'Agostino, who over the past 10 years has been a frequent guest on STEM-Talk. Today Dom joins us to give us an update on his recent research into ketogenic metabolic therapies, ketone supplements as well as hyperbaric oxygen therapy for traumatic brain injuries. Dom and his lab at the University of South Florida have published more than 20 papers since his last appearance on STEM-Talk in 2023. Dom is an Associate Professor in the Department of Molecular Pharmacology and Physiology at South Florida's Morsani College of Medicine. Dom has a background in neuroscience, molecular pharmacology, nutrition and physiology. In addition to developing and testing metabolic-based therapies, Dom's lab also investigates seizure disorders, brain cancer, neurodegenerative diseases and rare genetic-metabolic disorders. Show notes: [00:03:28] Dawn welcomes Dom back to the show and explaining that he has been quite busy since his last appearance, authoring or co-authoring more than 20 papers. Over the past several years, Dom has been helping to advance the science and application of ketogenic metabolic therapy (KMT) with colleagues at Moffitt Cancer Center, particularly focusing on using KMT to enhance immune-based therapies for certain types of cancers. Dawn asks Dom about this collaboration. [00:05:04] Dawn explains that ketogenic metabolic therapy is a dietary approach that focuses on a high-fat/low-carb diet to reduce glucose availability for cancer cells, potentially slowing their growth and improving treatment outcomes. It has been explored as a complimentary treatment for a variety of cancers including gliomas by shifting the metabolism of tumor cells away from glucose. Dawn asks Dom to explain what is involved in KMT. [00:06:58] Dawn clarifies that KMT requires less than 20-25 grams of carbohydrates per day, and that ketosis is a metabolic state in which the body switches from glucose metabolism to metabolizing fats in the form of ketones. Dawn goes on to explain that cancer cells typically consume glucose at a higher rate than normal cells. However, cancer cells are also very adaptable, and Dawn asks Dom to talk about this feature of cancer cells. [00:09:14] Ken explains that KMT has shown the most promise in treating high-grade gliomas, or brain cancers, such as glioblastoma, which is the most aggressive primary brain tumor in adults. Ken explains that Dom was part of a massive review titled “Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma,” which proposed guidelines for the management of glioblastoma based on an understanding of cancer as a metabolic disease, particularly involving mitochondria. Ken asks Dom to talk about this review. [00:11:21] From a patient advocacy perspective, Ken notes that the review recommends that there should be an aggressive education campaign that can arm patients with knowledge about KMT and other novel therapies. Ken asks Dom to talk about that recommendation. [00:13:15] Ken asks about the process of cutting the review from upwards of 200 pages down to around 50 pages with 49 authors. [00:15:04] Dawn mentions that Dom was part of another paper in 2024 titled “Targeting the mitochondrial stem cell connection in cancer treatment – a hybrid orthomolecular protocol.” Dawn explains that this paper looked at the mitochondrial stem cell connection theory (MSCC), which argues that cancer originates from chronic oxidative phosphorylation insufficiency in stem cells. This insufficiency leads to the formation of cancer stem cells and abnormal energy metabolism ultimately resulting in malignancy. There were 16 research centers and organizations involved in this paper which introduced a hybrid orthomolecular protocol to target the mitochondrial stem-cell connection. Dawn asks Dom to give an overview of MSCC. [00:18:26] Dawn explains that in this paper Dom and his co-authors propose a protocol that would enhance oxidative phosphorylation and inhibit the primary fuels of cancer, glucose and glutamine. This would target both cancer stem cells and metastasis. Dawn asks Dom to explain why this concept is attracting so much interest as a potential therapeutic approach for cancer. [00:20:48] Dawn asks if Dom could discuss the orthomolecular protocol, which is an approach that focuses on preventing and treating diseases by correcting nutritional balances in the body. [00:24:41] Ken asks if the proposed dietary intervention in the orthomolecular approach is different from a standard or typical ketogenic diet. [00:26:48] Ken shifts the discussion to talk about ketone supplements, explaining that Dom recently published a paper titled “Divergent hepatic outcomes of chronic ketone supplementation.” Ken goes on to explain that ketone salts preserve liver health, while some ketone esters and precursors appear to drive inflammation and steatosis. There is a lot of interest in ketone supplementation because they substantially elevate circulating ketones without having to restrict carbohydrates as strictly. The problem, as Ken explains, is that the long-term hepatic safety of ketone supplements remains unclear. In the aforementioned paper, Dom's rodent study evaluated the formulation-dependent impact of chronic ketone supplementation on liver histopathology, inflammatory signaling and systemic biomarkers. Ken asks Dom to discuss this paper and its findings and to give an overview of the various ketone supplements currently available. [00:30:49] Dawn asks Dom to dive into the methods and findings of the rodent study. [00:34:36] Ken asks Dom what his confidence is in the rodent model used in this study, and what are the next step for further research. [00:37:47] Regarding the two different doses given to rats in the study, Ken asks Dom how these doses correlate to doses in humans [00:40:23] Ken mentions that Ben Bikman, who was our guest on episode 143, published a study in February which Dom helped co-author. It examined the effects of ketone supplements on liver function. Ken asks Dom to discuss this study. [00:44:38] Dawn pivots to ask about a joint paper that Dom did with Andrew Koutnik, who was our guest on episode 185, on carbohydrates and physical performance titled “Carbohydrate ingestion on exercise metabolism and physical performance.” Dawn asks Dom to talk about this paper, which showed that a small amount of carbohydrates is sufficient to fuel athletic performance, and how additional carbohydrate intake showed diminishing returns. [00:49:18] Ken follows up on the finding that endurance athletes who rely on carb loading can tend toward pre-diabetes. [00:51:39] Ken asks Dom about the University of South Florida trial that Dom is an advisor for on traumatic brain injury and hyperbaric oxygen therapy. [00:54:41] Dawn mentions that Dom recently had an editorial in Frontiers that gave an overview of the emerging applications of hyperbaric/hyperbaric-oxygen therapy in the treatment of different neurological disorders. Dawn asks Dom what the key points in that editorial were. [00:59:06] Dawn explains that Dom recently gave a lecture at IHMC (available to view on IHMC's YouTube page), on traumatic brain injury and the populations at greatest risk in that context. Dawn asks Dom to give an overview of how an injury to the brain can result in neurometabolic crisis. [01:02:53] Ken asks Dom, excluding occupation demographics, what demographic is most at risk for traumatic brain injury (TBI) and why. [01:04:45] Ken mentions that it is understandable the risk that young people face with TBI due to the activities that young people engage in. Older people, however, have increased risk of TBI from falling as well as an additional age-related biological component that young people are not subject to. Ken asks Dom to elaborate on this. [01:07:12] Dawn mentions that several years ago, Dom and his wife bought some acreage in the countryside and started farming and asks Dom how the farm life is going. [01:07:57] Dawn closes the interview asking how Dom's wife is doing.