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Latest podcast episodes about DOI

Barbell & Bananas - Physio Podcast
92 - Romina Ghisoni - Sarkopenie verstehen: Was Physios wirklich wissen müssen

Barbell & Bananas - Physio Podcast

Play Episode Listen Later Jul 18, 2025 69:45


Willkommen liebe ZuhörerInnen! Diese Folge findet wieder im neuen Format statt: Speziell Nachgefragt! mit Romina Ghisoni . In diesem innovativen Format sprechen wir mit Autorinnen und Autoren der MSK (Thieme), um die zentralen Aspekte ihres Fachartikels zu vertiefen und durch spannende Diskussionen greifbarer zu machen – jederzeit und überall abrufbar.Wir thematisieren das Thema Sarkopenie: was Sarkopenie ist, wie es dazu kommt und welche Assessments wir als PhysiotherapeutInnen benutzen können. Wir erfahren auch wieso Sarkopenie nicht nur für in der Geriatrie ein wichtiges Thema ist. Welche Therapieansätze können wir also benutzen um das Thema zielgerichtet anzugehen?Wir tauchen kurz in die Vielfalt der Trainingsmöglichkeiten wie Schnelligkeit, Krafttraining aber auch Ausdauersport ein...

Aging-US
New Aging Clock Predicts Early Risk of Muscle Loss in Older Adults

Aging-US

Play Episode Listen Later Jul 17, 2025 4:14


BUFFALO, NY — July 17, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 6, on June 9, 2025, titled “Developing a quantitative estimate of muscle age acceleration by a novel phenotypic clock: cross-sectional study in healthy, middle-aged and older adults.” In this study, led by first authors Lucia Ventura, Antonella Cano and Marco Morrone, along with corresponding author Franca Deriu from the University of Sassari, researchers introduce a new method to predict how muscles age, offering an early warning system for sarcopenia, the condition of age-related muscle loss. The study demonstrates how a simple, low-cost approach can identify middle-aged and older adults at higher risk for declining muscle health, allowing timely preventive strategies. The researchers developed a tool called Muscle Age Acceleration (MAA), which measures how quickly an individual's muscles are aging compared to their actual age. By analyzing physical performance tests and body composition in 215 healthy participants aged 50 to 90 years, the researchers found that about 25% of individuals experience accelerated muscle aging. These individuals had a higher probability of developing sarcopenia, despite appearing healthy and not yet having received a diagnosis of the condition. Sarcopenia reduces muscle strength and physical performance, being a growing concern for older adults. It contributes to frailty, falls, and an increased risk of disability. Despite greater awareness, this condition often goes undetected until significant muscle loss occurs. This new muscular clock offers an opportunity to detect subtle changes in muscle health before they progress to more severe stages. By using common tests such as handgrip strength, walking speed, and mobility assessments, the MAA tool can classify individuals as having accelerated, normal, or decelerated muscle aging. Those with accelerated muscle aging also showed small changes in blood markers, suggesting early and hidden inflammation linked to muscle decline. This finding indicates that MAA may act as both a predictor of muscle-related aging and an indicator of overall health risks. “According to MAA, three trajectories were identified: accelerated agers displayed higher risk for sarcopenia (19%), as compared to normal (9%; p < 0.0001) and decelerated (2%; p < 0.0001), paralleled by significant subclinical alterations of haemato-chemical markers in accelerated agers.” If validated in future studies, this innovative approach could transform how clinicians and caregivers screen for early signs of sarcopenia. Its simplicity makes it suitable for use in clinics and community settings, helping older adults maintain independence and quality of life as they age. In summary, these findings highlight the importance of monitoring muscle health and physical performance in older adults. By detecting early signs of muscle aging with tools like MAA, interventions such as exercise and dietary changes can be introduced earlier, potentially delaying or preventing sarcopenia and its complications. DOI - https://doi.org/10.18632/aging.206269 Corresponding author - Franca Deriu - deriuf@uniss.it Video short - https://www.youtube.com/watch?v=kc9i0aJNNp0 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Oncotarget
New Antibody Selectively Targets Immune Cells That Suppress Anti-Tumor Responses

Oncotarget

Play Episode Listen Later Jul 16, 2025 3:49


BUFFALO, NY - July 16, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on July 9, 2025, titled “A novel anti-human CD25 mAb with preferential reactivity to activated T regulatory cells depletes them from the tumor microenvironment.” In this study, researchers from the National Institute of Allergy and Infectious Diseases, led by first author Maja Buszko and corresponding author Ethan M. Shevach, discovered a new monoclonal antibody that selectively targets a subset of immune cells called regulatory T cells (Tregs). These cells, while normally important for preventing autoimmunity, also can block the body's ability to fight cancer by suppressing anti-tumor immune responses. This discovery could lead to novel cancer therapies that strengthen the immune system's capacity to attack tumors. The researchers identified an anti-CD25 monoclonal antibody with several atypical properties and named it 2B010. To evaluate its effects, they used humanized mice, laboratory mice that are engineered to carry human immune cells, to closely mimic how human immune systems respond to cancer. The treatment of these mouse models with 2B010 significantly decreased the number of Tregs in tumors and boosted the activity of CD8+ T cells, which are essential for killing cancer cells. Importantly, 2B010 worked without disrupting other key immune functions. Unlike traditional Anti-CD25 antibodies, it did not interfere with interleukin-2 (IL-2) signaling, which is essential for the growth and activity of effector T cells that fight cancer. “2B010 also had no effect on IL-2 induced STAT5 phosphorylation or CD4+ T cell proliferation in vitro while both were blocked by Clone D1 further supporting the view that 2B010 does not recognize the IL-2 binding site.” This finding is especially significant because high levels of Tregs in tumors are associated with poor outcomes in many cancers. By specifically removing these cells, 2B010 may help overcome one of the main barriers to current immunotherapy approaches. Its ability to preserve IL-2 signaling could also make it safer and more effective when used alone or in combination with existing therapies such as immune checkpoint inhibitors. While the 2B010 antibody showed strong effects in reducing Tregs and boosting immune cell activity, the study did not observe changes in tumor size in these models. Researchers suggest this may be due to limitations in the preclinical systems used, such as the lack of tumor-specific T cells in humanized mice. Nevertheless, these findings demonstrate that 2B010 has a unique mechanism of action that could complement other cancer immunotherapies in future clinical trials. In conclusion, the development of 2B010 is a promising step toward selectively disrupting the immune suppressive environment in tumors. As researchers continue to refine and test this antibody, it could become a powerful tool for enhancing the effectiveness of cancer treatments and improving outcomes for patients. DOI - https://doi.org/10.18632/oncotarget.28752 Correspondence to - Ethan M. Shevach - eshevach@Niaid.NIH.gov Video short - https://www.youtube.com/watch?v=2NJcGsI7WXA Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28752 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, Treg, CD25, TME, mAb, GVHD To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Classroom Caffeine
A Conversation with Seth A. Parsons

Classroom Caffeine

Play Episode Listen Later Jul 15, 2025 45:32 Transcription Available


Send us a textDr. Seth Parsons talks to us about the power of the teacher, the value of good curriculum, and motivation and engagement in learning. Seth is known for his work in the areas of elementary literacy instruction, student engagement and motivation, adaptive teaching, and metacognitive strategy development. His research has been published in many of the field's top journals, including the Journal of Literacy Research, Review of Educational Research, Educational Researcher, Reading Research Quarterly, Elementary School Journal, The Reading Teacher, and Literacy Research and Instruction. In addition to journal articles, he has co-authored and edited several practitioner-facing books, including Principles of Effective Literacy Instruction, Grades K–5, and Accelerating Learning Recovery for All Students (both co-authored with past Classroom Caffeine guest Margaret Vaughn) and Becoming a Metacognitive Teacher. He has served as President of Association of Literacy Educators and Researchers (ALER) and currently serves as Executive Editor of The Journal of Educational Research, and Co-Editor of the Literacy Research Association's Journal of Literacy Research, and Associate Editor of Reading and Writing Quarterly. Dr. Seth A. Parsons is a Professor of Literacy in the Sturtevant Center for Literacy at George Mason University. You can connect with Seth on Instagram @sethaparsons or by email at sparson5@gmu.edu. To cite this episode: Persohn, L. (Host). (2025, July 15). A conversation with Seth A. Parsons. (Season 5, No. 12) [Audio podcast episode]. In Classroom Caffeine Podcast series. https://www.classroomcaffeine.com/guests. DOI: 10.5240/E135-3828-6E19-4385-B8E5-YConnect with Classroom Caffeine at www.classroomcaffeine.com or on Instagram, Facebook, Twitter, and LinkedIn.

Deconstructing Disney

Episode SummaryErin and Rachel discuss Bolt (2008), a lesser known film about a dog who thinks he's a super hero. Under new leadership, Disney Animation Studios starts to come out of their slump with this film that some people found boring (Erin) and others found heartwarming (Rachel). Episode BibliographyAmidi, A. (2006, December 18). Chris Sanders No Longer Directing American Dog. Cartoon Brew. https://www.cartoonbrew.com/disney/chris-sanders-no-longer-directing-american-dog-2407.htmlBolt. (n.d.). Box Office Mojo. https://www.boxofficemojo.com/release/rl1531348481/Bolt (2008 film). (n.d.). Wikipedia. https://en.wikipedia.org/wiki/Bolt_(2008_film)Catmull, E., & Wallace, A. (2014). Creativity, Inc.: Overcoming the Unseen Forces That Stand in the Way of True Inspiration. Random House Publishing Group.Desowitz, B. (2008, December 4). The Digital Eye: How 'Bolt' Got Painterly. Animation World Network. https://www.awn.com/vfxworld/digital-eye-how-bolt-got-painterlyDonofrio, E. C. (2013). The wonderful world of gender roles: A look at recent Disney children's films [Honors thesis, Boston College]. https://core.ac.uk/reader/151481530DVD Deleted Scenes. (2024, October 7). Bolt (2008) | Behind the Scenes + Deleted Scenes. YouTube. https://www.youtube.com/watch?v=xsEyzc4FVZEEvry, M. (2020, February 13). Exclusive: Kiskaloo Movie Could Be Next for Chris Sanders! ComingSoon.net. https://www.comingsoon.net/movies/news/1122952-exclusive-kiskaloo-movie-could-be-next-for-chris-sandersFleming, M. (2002, November 18). ‘Lilo' scribes stitch Disney package. Variety. https://variety.com/2002/scene/markets-festivals/lilo-scribes-stitch-disney-package-1117876239/Fritz, B. (2006, December 1). Disney lays off animators. Variety. https://variety.com/2006/digital/features/disney-lays-off-animators-1117954931/Fritz, B. (2007, March 27). Sanders joins DreamWorks. Variety. https://variety.com/2007/digital/markets-festivals/sanders-joins-dreamworks-1117961927/From the creator of LILO & STITCH our first look at AMERICAN DOG!!!! (2004, August 16). Ain't It Cool News. https://legacy.aintitcool.com/node/18156Hedrick, D. (2010). King Lear or Bolt: The entertainment unconscious from CalArts to Disney. Shakespeare Studies, 38, 37-47. Hill, J. (2007, February 12). Toon Tuesday : How Disney is fixing “American Dog”. Jim Hill Media. https://jimhillmedia.com/toon-tuesday-how-disney-is-fixing-american-dog/Howard, B., & Williams, C. (Directors). (2008). Bolt [Film]. Walt Disney Animation Studios.Hurt, L.S. (2014). Fuzzy toys and fuzzy feelings: How the “Disney” culture provides the necessary psychological link to improving animal welfare. Journal of Animal & Natural Resource Law, 10, 253-272.McCarthy, T. (2008, November 13). Bolt. Variety. https://variety.com/2008/digital/awards/bolt-3-1200472217/Ness, M. (2016, November 17). An Adorable Dog in an Unbelievable Premise: Disney's Bolt. Reactor. https://reactormag.com/an-adorable-dog-in-an-unbelievable-premise-disneys-bolt/Porter, P. (2009). Journeys toward an authentic self. Society and Animals, 17, 368-375. DOI: 10.1163106311109X12474622855345Rechtshaffen, M. (2008, November 13). Film Review: Bolt. The Hollywood Reporter. https://web.archive.org/web/20081216015641/https://www.hollywoodreporter.com/hr/film/reviews/article_display.jsp?JSESSIONID=prd6JhJJnvQL9cYrfRKSHVQjP6dRnLhLH4SZ1KQht3tfhVLxmjqn!-591095386&&rid=11956Robinson, T. (2008, November 20). Bolt. AV Club. https://www.avclub.com/bolt-1798205268Scott, A. O. (2008, November 20). Canine TV Action Star Discovers that Life is the Best Reality Show. The New York Times. https://www.nytimes.com/2008/11/21/movies/21bolt.htmlSeibert, P. (2008). Bolt: Review. TV Guide. https://web.archive.org/web/20120212213609/http://movies.tvguide.com/bolt/review/294809Springy. (2023, October 11). American Dog: everything I found in one neat thread. forums.lostmediawiki.com. https://forums.lostmediawiki.com/thread/12742/american-dog-neat-threadTuran, K. (2008, November 21). ‘Bolt' spices up Disney with a dash of Pixar. Los Angeles Times. https://www.latimes.com/archives/la-xpm-2008-nov-21-et-bolt21-story.htmlWang, T. (2021). Bolt (2008): Journey to the authentic self. In S. M. Alegre (Ed.), Gender in 21st century animated children's cinema (pp. 86-87). https://ddd.uab.cat/pub/llibres/2021/236285/gen21cen_a2021.pdfWolff, E. (2009, February 5). Animated Oscar noms took long road. Variety. https://variety.com/2009/film/awards/animated-oscar-noms-took-long-road-1117999618/

Aging-US
How Telomerase Inactivation in Aging Cells Influences Cancer Growth and Metastasis

Aging-US

Play Episode Listen Later Jul 15, 2025 3:30


BUFFALO, NY — July 15, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 6, on June 5, 2025, titled “Senescence caused by telomerase inactivation in myeloid, mesenchymal, and endothelial cells has distinct effects on cancer progression.” In this study, first author Joseph Rupert, along with corresponding author Mikhail G. Kolonin and colleagues from The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, McGovern Medical School, at The University of Texas Health Sciences Center at Houston, investigated how aging-related changes in different cell types affect cancer progression. By turning off telomerase in specific cell populations in mice, the researchers discovered that cell aging, or senescence, can slow primary tumor growth but also trigger unexpected effects. This work sheds light on the complex relationship between aging cells and cancer and may help guide future anti-cancer strategies. The team used genetically modified mice to deactivate telomerase, the enzyme that maintains chromosome ends, specifically in immune, connective tissue, and blood vessel cells. This caused these cells to enter a state of senescence, where they stop dividing and release inflammatory signals. The researchers then implanted breast, prostate, and pancreatic cancer cells into the mice and tracked how tumors developed. They found that when telomerase was inactivated in immune cells or connective tissue cells, tumors grew more slowly. However, these tumors showed signs of increased tissue damage and potential aggressiveness. Interestingly, when telomerase was turned off in endothelial cells, which cover blood vessels, tumors shrank and became poorly supplied with blood, leading to oxygen deprivation. In the case of pancreatic cancer cells, this low-oxygen environment made them more likely to spread to the liver, highlighting a potential risk of targeting these cells. “[…] this study shows that senescence and metabolic dysfunction resulting from telomerase inactivation in distinct cells in the tumor microenvironment have different effects on tumor growth and metastasizing of carcinomas.” This research provides important insights into how aging cells within the tumor microenvironment (TME) influence cancer behavior. While senescence in certain cell types can help suppress tumor growth, it may also create conditions that favor cancer metastasis. These findings highlight the need to consider cell type-specific effects when developing therapies that target senescent cells. By mapping how different cell populations contribute to cancer progression in aging tissues, this study opens the door for more precise approaches to prevent both tumor growth and spread. DOI - https://doi.org/10.18632/aging.206268 Corresponding author - Mikhail G. Kolonin - mikhail.g.kolonin@uth.tmc.edu Video short - https://www.youtube.com/watch?v=py8wFKj7enE Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206268 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, senescence, telomerase, myeloid, mesenchymal, endothelial To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Aging-US
Behind the Study: Enhancing Oocyte Activation in Women with Ovarian Failure

Aging-US

Play Episode Listen Later Jul 15, 2025 8:23


Dr. Amparo Santamaria describes a #research paper she co-authored that was #published in Volume 17, Issue 6 of Aging (Aging-US), titled “Enhancing oocyte activation in women with ovarian failure: clinical outcomes of the Stem Cell Regenera study using G-CSF mobilization of peripheral blood stem cells and intraovarian injection of stem cell factor-enriched platelet rich plasma in real-world-practice.” DOI - https://doi.org/10.18632/aging.206274 Corresponding author -Amparo Santamaria - Amparo.santamaria@ivirma.com Video interview - https://www.youtube.com/watch?v=oRFJNwnXZWI Abstract The study assesses the effectiveness and safety of the Stem Cell Regenera Treatment for oocyte activation in women with ovarian failure, including conditions such as Poor Ovarian Response (POR), Diminished Ovarian Reserve (DOR), and Premature Ovarian Insufficiency (POI). This retrospective observational study was conducted from January 2023 to December 2024 at the IVIRMA Alicante Clinics in Spain. Women diagnosed with ovarian failure participated in the study, which involved mobilizing Hematopoietic Stem Cells from bone marrow into peripheral blood using granulocyte colony- stimulating factor (G-CSF). This was followed by an intraovarian injection of Stem Cell Factor- enriched Platelet Rich Plasma (SCFE-PRP). The primary outcome measures were the rate of oocyte activation, leukocytes and stem cell count, and pregnancy rates. Oocyte activation was defined as an increase in total Antral Follicle Count of three or more follicles after treatment and/or at least a 20% rise in Anti-Müllerian Hormone levels. Safety was assessed based on adverse effects. Pregnancy rates were evaluated for both spontaneous gestation and following in vitro fertilization (IVF) treatment. A total of 145 women participated: the overall activation rate was 68.28%, with 7.07% achieving spontaneous gestation and 14.14% achieving pregnancy following IVF. Mobilization of CD34+ cells was successful in all participants, with an average collection of 32.96 CD34+ cells/μl. No severe adverse effects were observed. The study concluded that the Stem Cell Regenera Treatment is effective and safe for oocyte activation in women with ovarian failure in real-world practice. Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206274 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, Stem Cell Regenera, oocyte activation, ovarian regeneration, G-CSF, SCFE-PRP, ovarian failure To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

PedsCrit
Fellowship Project Design with Dr. Mike Spaeder -- Part 2

PedsCrit

Play Episode Listen Later Jul 14, 2025 41:32


Learning Objectives:By the end of this series, listeners should be able to:Understand the research expectations of PICU Fellows in the United States.Explain the types of research available to PICU fellows and how a new fellow might explore their local options. Explain the work necessary to refine a research question and write mature specific aims for a project.  Understand the key factors involved in getting a fellowship paper submitted, including the common pitfalls for each type of research About our Guest: Mike Spaeder is a Professor of Pediatrics at the University of Virginia (UVA) School of Medicine and a pediatric critical care physician at the UVA Children's Hospital in Charlottesville, Virginia. He received his bachelor's degree in mathematics from Trinity College and his master's in statistics from George Washington University, where he also received his medical degree. He completed his pediatrics residency at Hasbro Children's Hospital/Brown University and his pediatric critical care fellowship at the Johns Hopkins Hospital. He is now the director of the Pediatric Critical Care fellowship at the UVA Children's Hospital. His research is based at the Center for Advanced Medical Analytics at the University of Virginia, where he focuses on modeling physiologic signatures of illness to identify patients at risk for clinical deterioration. Selected References:Horvat CM, Hamilton MF, Hall MW, McGuire JK, Mink RB Child Health Needs and the Pediatric Critical Care Medicine Workforce: 2020-2040. Pediatrics 2024 Feb 1 153Tasker RC. Writing for PCCM: The 3,000-Word Structured Clinical Research Report. Pediatr Crit Care Med. 2021 Mar 1;22(3):312-317.Sanchez-Pinto, L. Nelson MD, MBI1; Badke, Colleen M. MD, MS1; Pololi, Linda MBBS, FRCP (hon)2. Group Peer Mentoring: A Strategy to Promote Career Development and Improve Well-Being Among Early-Career Faculty in Pediatric Critical Care Medicine. Pediatric Critical Care Medicine ():10.1097/PCC.0000000000003763, May 15, 2025. | DOI: 10.1097/PCC.0000000000003763 Scott K. Radical Candor: Be a Kick-Ass Boss Without Losing Your Humanity. New York: St. Martin's Press; 2017. 1st ed. Equator Guidelines: https://www.equator-network.org/For Authors : Pediatric Critical Care MediQuestions, comments or feedback? Please send us a message at this link (leave email address if you would like us to relpy) Thanks! -Alice & ZacSupport the showHow to support PedsCrit:Please complete our Listener Feedback SurveyPlease rate and review on Spotify and Apple Podcasts!Donations are appreciated @PedsCrit on Venmo , you can also support us by becoming a patron on Patreon. 100% of funds go to supporting the show. Thank you for listening to this episode of PedsCrit. Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at pedscritpodcast@gmail.com. Check out http://www.pedscrit.com for detailed show notes. And visit @critpeds on twitter and @pedscrit on instagram for real time show updates.

Betreutes Fühlen
Impostor-Syndrom: das Gefühl, nichts zu können

Betreutes Fühlen

Play Episode Listen Later Jul 14, 2025 79:13


Ich kann nichts. Ich bin nichts wert. Wenn ich etwas schaffe, ist es nur Glück. Wann fliege ich auf? Wann merken die anderen, dass ich ein Hochstapler bin? Wie kann es sein, dass viele von uns trotz nachweisbarer Erfolge im Leben ständig befürchten, irgendwann aufzufliegen? Was das mit unserer Kindheit und struktureller Ungerechtigkeit zu tun hat, erfahrt ihr hier. Atze und Leon erklären in dieser Folge das Hochstapler-Syndrom, das eigentlich gar kein Syndrom ist. Fühlt euch gut betreut Leon & Atze Unsere bisherige Folge dazu: Hochgestapelt, tief gefallen (30. Juni 2020) Impostor: Wie fake bist du? | Terra Xplore mit Leon Windscheid & Lutz van der Horst https://www.youtube.com/watch?feature=shared&t=867&v=w2iqnFglAbg Bravata, D. M., Watts, S. A., Keefer, A. L., Madhusudhan, D. K., Taylor, K. T., Clark, D. M., ... & Hagg, H. K. (2020). Prevalence, predictors, and treatment of impostor syndrome: a systematic review. Journal of general internal medicine, 35, 1252-1275. DOI: 10.1007/s11606-019-05364-1 McElwee, R. O., & Yurak, T. J. (2010). The phenomenology of the impostor phenomenon. Individual Differences Research, 8(3), 184-197. Clance, P. R., & Imes, S. A. (1978). The imposter phenomenon in high achieving women: Dynamics and therapeutic intervention. Psychotherapy: Theory, Research & Practice, 15(3), 241–247. https://doi.org/10.1037/h0086006 Leary, M. R., Patton, K. M., Orlando, A. E., & Wagoner Funk, W. (2000). The impostor phenomenon: Self‐perceptions, reflected appraisals, and interpersonal strategies. Journal of personality, 68(4), 725-756. https://doi.org/10.1111/1467-6494.00114 Sakulku, J. (2011). The impostor phenomenon. The Journal of Behavioral Science, 6(1), 75-97. https://doi.org/10.14456/ijbs.2011.6 Evans, D. (2022, 18. April). Viola Davis on Hollywood: ‘You either have to be a Black version of a white ideal, or you have to be white'. The Guardian. Covington, M. V. (1984). The self-worth theory of achievement motivation: Findings and implications. The elementary school journal, 85(1), 5-20. https://www.journals.uchicago.edu/doi/epdf/10.1086/461388 Thompson, T., Davis, H., & Davidson, J. (1998). Attributional and affective responses of impostors to academic success and failure outcomes. Personality and Individual differences, 25(2), 381-396. https://doi.org/10.1016/S0191-8869(98)00065-8 Tumminia, A. M. (2023). When Feeling Like a Fake Takes a Toll on your Work: Examining the Moderating Effect of Task Characteristics on the Relationship Between Impostorism and the Use of Dysfunctional Work Strategies (Doctoral dissertation, City University of New York). Clance, P. R. (1985). Clance impostor phenomenon scale. Personality and Individual Differences. https://doi.org/10.1037/t11274-000 Clance, P. R. The Impostor Test and scoring [PDF]. Pauline Rose Clance. Abgerufen am 10. Juli 2025 von https://www.paulineroseclance.com/pdf/IPTestandscoring.pdf Clance, P. R. Impostor Phenomenon. Pauline Rose Clance. Abgerufen am 10. Juli 2025 von https://www.paulineroseclance.com/impostor_phenomenon.html Price, P. C., Holcomb, B., & Payne, M. B. (2024). Gender differences in impostor phenomenon: A meta-analytic review. Current Research in Behavioral Sciences, 100155. https://doi.org/10.1016/j.crbeha.2024.100155 Romano, N. (2016, 4. August). Viola Davis remembers her early childhood on a former plantation. Entertainment Weekly. https://web.archive.org/web/20181125204332/https://ew.com/article/2016/08/04/viola-davis-childhood-home-former-plantation/ Feenstra, S., Begeny, C. T., Ryan, M. K., Rink, F. A., Stoker, J. I., & Jordan, J. (2020). Contextualizing the impostor “syndrome”. Frontiers in psychology, 11, 575024. https://doi.org/10.3389/fpsyg.2020.575024

Oncotarget
Prostate Cancer Cells Survive Treatment by Storing Fat in Low Oxygen Conditions

Oncotarget

Play Episode Listen Later Jul 14, 2025 3:47


BUFFALO, NY – July 14, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on June 25, 2025, titled “Hypoxia induced lipid droplet accumulation promotes resistance to ferroptosis in prostate cancer.” In this study, researchers led by Shailender S. Chauhan and Noel A. Warfel from the University of Arizona discovered that prostate cancer cells survive treatment by storing fats in tiny cellular compartments when oxygen levels are low. This process makes the cancer cells less vulnerable to a type of cell death known as ferroptosis. The findings provide new insight into why prostate tumors often resist therapies and suggest potential strategies to improve treatment outcomes. This study focused on ferroptosis, a form of programmed cell death that relies on iron and lipid oxidation to destroy cancer cells. Researchers tested prostate cancer cells under normal and low oxygen conditions and found that hypoxia, or reduced oxygen levels, allowed cancer cells to build up lipid droplets (LD). These structures act as storage units for fats, shielding cancer cells from oxidative damage and preventing ferroptosis from occurring. The researchers found that this adaptation of prostate cancer cells made them less sensitive to ferroptosis-inducing drugs like Erastin and RSL3, even when these drugs were combined for a stronger effect. The team also reported that hypoxia caused significant changes in lipid metabolism, decreasing the availability of specific fatty acids that normally promote ferroptosis. “Transcriptomic analysis revealed that hypoxia significantly reduced the expression of genes related to incorporating polyunsaturated fatty acids into phospholipids (ACSL4, LPCAT3), and parallel lipidomic analysis demonstrated that hypoxia significantly decreased the levels of the ferroptosis-prone lipid class, phosphatidylethanolamine (PE) and increased production of neutral lipid species, cholesteryl ester (ChE (22:5)) and triglycerides (TG(48:1), TG:(50:4), and TG(58:4)).” This research highlights the importance of the tumor microenvironment, particularly oxygen levels, in shaping how cancer cells respond to therapy. By altering their metabolism and storing lipids, prostate tumors may evade treatments designed to trigger ferroptosis. These findings underscore the need to develop new strategies targeting LD dynamics or lipid metabolism to overcome this resistance. Understanding how prostate cancer (Pca) adapts to survive in hypoxic conditions offers a potential avenue for improving therapies. For example, preventing lipid accumulation in cancer cells or releasing stored fats may restore their sensitivity to ferroptosis and improve the effectiveness of current therapies. This approach could have broader implications for treating other solid tumors that share similar metabolic features. DOI - https://doi.org/10.18632/oncotarget.28750 Correspondence to - Noel A. Warfel - warfelna@arizona.edu, and Shailender S. Chauhan - shailenderc@arizona.edu Video short - https://www.youtube.com/watch?v=xFypDT4ALmc Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28750 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, hypoxia, lipid droplets, ferroptosis, resistance, prostate To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Rivista di Psicoanalisi - Podcast
Il Dialogo fra Ricercatori e Clinici. Davide Elos intervista Giulio Cesare Zavattini e Anna Daniela Linciano

Rivista di Psicoanalisi - Podcast

Play Episode Listen Later Jul 14, 2025 66:24


In questo episodio del podcast che fa riferimento al Focus dal titolo "Il dialogo fra ricercatori e clinici. Le teorie private dei pazienti e degli analisti" pubblicato sul volume 2/2025 della Rivista di Psicoanalisi intervistiamo il Professor Giulio Cesare Zavattini e la Dottoressa Daniela Linciano.Nella prima parte del podcast Giulio Cesare Zavattini discute ed argomenta l'importanza del dialogo fra psicoanalisti e ricercatori per sostenere ed alimentare la vitalità della Psicoanalisi.Nella seconda parte dell'episodio Daniela LInciano ci illustra le tappe, gli strumenti, la composizione del gruppo di lavoro ed i risultati del progetto di ricerca multicenrico italo-svedese BEP (Beginnings and endings in Psychoanalysis and Psychoanalytic Psichoterapy).Giulio Cesare Zavattini Psicoanalista della Società Psicoanalitica Italiana (SPI) e dell'International Psycho-Analytical Association (IPA); Membro del Tavistock Relationships Association of Psychotherapists and Counsellors (TRAPC)); Membro dell'International Association of Couple and Family Psychoanalysis (IACFP).  già Professore Ordinario di “Psicopatologia delle relazioni di coppia e genitoriali” e Docente di ‘Psicoterapia psicoanalitica della coppia' nella Specializzazione in Psicologia clinica', Facoltà di Medicina e Psicologia, Sapienza Università di Roma.  Fa parte della Redazione di ‘Interazioni'; ‘Terapia familiare'; del Comitato dei Garanti del ‘Giornale Italiano di Psicologia'. E' membro dell'International Advisory Board del Journal of Couple and Family Psychoanalysis. Ha fatto parte della Redazione di ‘Rivista di psicoanalisi'  negli anni 2020- 2024 dove si è occupato della Sezione di Ricerca e metodo insieme a Daniela Rao. Attualmente fa parte del Comitato di Lettura di Rivista di Psicoanalisi per il quadriennio che è ora iniziato I suoi interessi scientifici riguardano sul piano della ricerca empirica la regolazione delle emozioni, l'attaccamento adulto e le relazioni sentimentali, le relazioni genitori e figli adottivi; sul piano della ricerca clinica si è occupato dello studio dei modelli psicoanalitici, l'adolescente e la sua famiglia, la psicoanalisi di coppia e l'uso clinico del sogno.  Pubblicazioni recenti Zavattini G.C. (2025). Per un futuro good enough della Psicoanalisi nell'Università. Rivista di psicoanalisi, 7(1): 197- 202.   DOI: 10.26364/RPSA 20250710197  * Ammaniti M, Zavattini G.C. (2024). Nino Dazzi, la psicoterapia e psicoanalisi. Giornale Italiano di Psicologia, LI(4): 871-876. DOI: 10.1421/115020 Ballarotto G., Zavattini G.C. (2024). La dipendenza dai videogiochi e dalla pornografia online in adolescenza: risposta al dibattito emerso. Psicologia clinica dello sviluppo, XXVII(3): 471-476. Bruno S., Velotti P., Zavattini G.C. (2024). Lo studio della regolazione emotiva nella pratica clinica: dal modello teorico all'impatto sociale. Giornale Italiano di Psicologia, 1:27-46.  DOI: 10.1421/112887. Monguzzi F., Zavattini G.C. (2023). The Intersubjective function of the dream in the psychoanalytic couple psychotherapy. Journal of Couple and Family Psychotherapy, 13(2): 152-165. * Velotti P., Zavattini G.C. (2023). ‘Teorie dell'azione terapeutica. Tra interpretazione e relazione', Il Mulino, Bologna. * Velotti P., Rogier G., Beomonte Zobel S., Chirumbolo A., Zavattini G.C. (2022).  The Relation of Anxiety and Avoidance Dimensions of Attachment to Intimate Partner Violence: A Meta-Analysis About Perpetrators. Trauma, Violence, and Abuse, 23, (1): 196-212. DOI 10.1177/1524838020933864 Pace C.S., Muzi, S., Senso, A., Zavattini, G.C., Madera, F. (2022), Can the Family Drawing be a useful tool for assessing attachment representations in children? A systematic review and meta-analysis, Attachment & Human Development, 24(4): 477-502 DOI: 10.1080/14616734.2021.1991664,  de Campora G., Zavattini G.C. (2021). Mindfulness and Eating Disorders across Lifespan. Assessment and Intervention Across the Lifespan.  Routdlege, London pp. 1-120. DOI: 10.4324/9781003154266 Velotti P., Zavattini G.C. (2019). È ancora attuale l'uso del sogno nella pratica clinica? Giornale italiano di Psicologia, 3:433-462, DOI: 10.1421/94505 * Anna Daniela Linciano è medico, psichiatra e psicoanalista. Membro Ordinario della Società Psicoanalitica Italiana (SPI) e Full Member della International Psychoaanalytical Association (IPA). Vincitrice del premio Tyson 2011 dell'International Psychoanalytical association (IPA).  È stata membro di Redazione della Rivista di Psicoanalisi nel quadriennio 2012-2016 e membro del Comitato di Lettura della stessa Rivista quadriennio che si è appena concluso. Ha partecipato e partecipa tutt'ora a diversi gruppi di studio e di ricerca presso il Centro Milanese di Psicoanalisi.  È stata nel 2014 Co-Researcher di un progetto di ricerca, che ha ricevuto un grant IPA, sull'integrazione delle terapie psicoanalitiche agevolate con i servizi pubblici e successivamente. Nel 2016 Principal Investigator (PI) del gruppo di ricerca BEP, che pure ha vinto un secondo  Grant IPA ed i cui sviluppi e risultati sono oggetto del Focus dedicato alla ricerca dell'ultimo numero in uscita della Rivista di Psicoanalisi.

Arquitetura Objetiva
Visual Merchandising

Arquitetura Objetiva

Play Episode Listen Later Jul 14, 2025 13:06


Não comece um projeto de arquitetura comercial sem conhecer como a fachada, o layout, a luz e as cores podem ajudar a fortalecer marcas e a aumentar as vendas. Dê o play para entender o que é e como funciona o Visual Merchandising.SIGA >>> https://www.instagram.com/arquiteturaobjetiva/CAPA: Projeto do escritório Snohetta para a loja Holzweiler Fornebu Multi-Brand Store | Foto: Magnus Nordstrand | https://www.snohetta.com/projects/holzweiler-fornebu-multi-brand-storeREFERÊNCIAS:BATISTA, Karen; ESCOBAR, Maria Andrea Rocha. A IMPORTÂNCIA DO VISUAL MERCHANDISING NA PERCEPÇÃO DOS CONSUMIDORES. Revista Gestão em Análise, Fortaleza, v. 9, n. 1, p. 93–108, 2020. DOI: 10.12662/2359-618xregea.v9i1.p93-108.2020. Disponível em: https://periodicos.unichristus.edu.br/gestao/article/view/2567. Acesso em: 12 jul. 2025.

Communicable
Communicable E31: Climate change and fungal spread

Communicable

Play Episode Listen Later Jul 13, 2025 51:53


The adaptability of fungi to warmer temperatures is an obvious consequence of climate change. Perhaps less obvious is the role climate change has played on fungal pathogens emerging as a global health concern. While humans are mostly protected from fungal infections by our immune system and body temperature, a warming global climate could subvert the status quo. Some fungi are already adapted to warmer temperatures and causing invasive acute infections in humans: Candidozyma auris, Cryptococcus neoformans, and Aspergillus fumigatus, to name a few.  In this episode of Communicable, Angela Huttner and Josh Nosanchuk invite Arturo Casadevall, a Bloomberg Distinguished Professor at Johns Hopkins and this year's recipient of ESCMID's Excellence in Science Award, to discuss the world of fungi and their pathogenic potential in a warming world. Other topics include how to prepare for their emergence as a health threat, how fungi can be harnessed for applications that can benefit us, and ultimately answering the question Casadevall himself posed in the title of his recently published book, What if fungi win?This episode was edited by Kathryn Hostettler and peer reviewed by Robin Aerts of University Hospital Antwerp, Belgium.  References1.        Casadevall, A with Desmon S. What if fungi win? Johns Hopkins University Press, 2024.2.        Smith DFG, et al. Environmental fungi from cool and warm neighborhoods in the urban heat island of Baltimore City show differences in thermal susceptibility and pigmentation. BioRxiv 2025. DOI: 10.1101/2023.11.10.566554  3.        Casadevall A and Pirofski L. Benefits and Costs of Animal Virulence for Microbes. mBio 2019. DOI: 10.1128/mBio.00863-194.        Cordero RJB et al. Radiation protection and structural stability of fungal melanin polylactic acid biocomposites in low Earth orbit. PNAS 2025. DOI: 10.1073/pnas.24271181225.        Dadachova E, et al. The radioprotective properties of fungal melanin are a function of its chemical composition, stable radical presence and spatial arrangement. Pigment Cell Melanoma Res 2008. DOI: 10.1111/j.1755-148X.2007.00430.x6.        Cordero RJB et al. The hypothermic nature of fungi. PNAS 2022. DOI: 10.1073/pnas.2221996120

Pediheart: Pediatric Cardiology Today
Pediheart Podcast #348: Melody Valve Outcomes In The Atrioventricular Position In The Small Child

Pediheart: Pediatric Cardiology Today

Play Episode Listen Later Jul 11, 2025 23:55


This week we review a recent surgical paper on the 'off-label' use of the Melody valve for replacement of the AV valve in small infants and children. How effective and safe was this procedure? What factors were associated with the need for reintervention and what sorts of reinterventions were most common? Why was catheter based reintervention rarely employed? What sort of anti-coagulation protocol seems best to protect these valves? Assistant Professor of Pediatrics at the University of Nebraska, Dr. Samantha Gilg shares the insights from her work this week. DOI: 10.1007/s00246-024-03538-1

Vorlesungen zur Linguistik und Sprachgeschichte des Deutschen
Mehr Ausblick als Zusammenfassung (Sprache und Religion | SoSe 2025 | #175)

Vorlesungen zur Linguistik und Sprachgeschichte des Deutschen

Play Episode Listen Later Jul 11, 2025 69:02


Traditionell wäre hier nur eine Zusammenfassung erwartbar gewesen. Aber ich nutze die letzte Vorlesung zu #SpracheUndReligion vor allem dazu, um die Aspekte zu benennen, die in der Vorlesung zu kurz gekommen sind. Wenn Sie Lust haben, verfolgen Sie doch auch das Seminar dazu im Wintersemester. Zumindest die Inputphase wird auf Youtube online sein. Hier geht es spätestens im Oktober weiter mit einer Auffrischung der Konstruktionsgrammatik. Präsentation (*.pdf): Alexander Lasch. 2025. Sprache und Religion. Zenodo. DOI: ⁠⁠⁠⁠⁠⁠⁠https://doi.org/10.5281/zenodo.15175420⁠⁠⁠⁠⁠⁠⁠. Videoaufzeichnungen: ⁠⁠⁠⁠⁠⁠⁠https://youtube.com/@AlexanderLasch⁠⁠⁠⁠⁠⁠⁠. Informationen & Material zu allen Vorlesungen: ⁠⁠⁠⁠⁠⁠⁠https://kurzelinks.de/fl7f⁠⁠⁠⁠⁠⁠⁠. Worksheet zu den Vorlesungen: ⁠https://kurzlinks.de/WorksheetVorlesungen⁠. Intro: "Reflections" von Scott Holmes (CC BY via ⁠⁠⁠⁠⁠⁠FMA⁠⁠⁠⁠⁠⁠).#Linguistik #OER #Sprache #Sprachwissenschaft #Religion #Religionslinguistik

Aging-US
Spermidine and Protein Restriction Independently Protect Brain and Body from Aging in Flies

Aging-US

Play Episode Listen Later Jul 10, 2025 3:57


BUFFALO, NY — July 10, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 6, on June 7, 2025, titled “Spermidine supplementation and protein restriction protect from organismal and brain aging independently.” In this study, led by YongTian Liang and Stephan J. Sigrist from Freie Universität Berlin, Charité Universitätmediz Berlin, and the Leibniz-German Center for Neurodegenerative Diseases (DZNE), researchers investigated how spermidine, a natural substance in the body, and protein intake levels influence aging in fruit flies. They found that spermidine supplementation and changes in protein intake influenced brain health and aging in distinct ways. These insights could guide the development of new strategies to slow age-related decline in humans. “In this study, we combined low- and high-protein diets (2% versus 12% yeast in food) with spermidine supplementation in aging Drosophila fruit flies.” Aging of the brain and body contributes to cognitive decline and diseases in older populations. Scientists have long explored dietary restriction and fasting as ways to slow these processes. This study reveals that spermidine supplementation supports brain health by enhancing mitochondrial function and memory, while protein restriction independently promotes longevity and protects against movement decline. The researchers discovered that spermidine improved memory and preserved physical activity in aging flies regardless of protein intake. In contrast, reducing protein alone boosted mitochondrial activity and extended lifespan without directly enhancing memory. Importantly, the combined approach of protein restriction and spermidine supplementation provided additive benefits, suggesting potential for synergistic effects. This work highlights that spermidine acts through a pathway involving hypusination, a vital process where cells modify proteins to support energy production and repair, while protein restriction works via nutrient-sensing pathways that promote longevity. These independent mechanisms may explain why combining the two interventions offers greater protection against aging effects. Although conducted in flies, the study underscores the possibility of designing dietary and supplement-based interventions to combat human age-related decline. As spermidine levels naturally decline with age, supplementation combined with moderated protein intake could offer a safe way to promote brain health and longevity in humans. The authors point out that it takes further studies in mammals and humans to validate these results. If confirmed, such strategies could lead the way for accessible approaches to promote healthy aging and reduce the burden of cognitive disorders in older populations. DOI - https://doi.org/10.18632/aging.206267 Corresponding authors - YongTian Liang - yongtian.tim.liang@gmail.com, and Stephan J. Sigrist - stephan.sigrist@fu-berlin.de Video short - https://www.youtube.com/watch?v=QfxpK9tka7U Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206267 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, brain aging, spermidine, protein restriction, mitochondria To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

AJP-Heart and Circulatory Podcasts
Allostatic Load and Cardiometabolic Health

AJP-Heart and Circulatory Podcasts

Play Episode Listen Later Jul 9, 2025 37:50


How can we better understand the developmental nature of cardiovascular disease across the life course and improve the health of people who experience chronic early life stress? In this episode Dr. Nathaniel Jenkins (University of Iowa) interviews lead author Dr. Annemarie Wentzel (North-West University, South African Medical Research Council Unit for Hypertension and Cardiovascular Disease) and expert Dr. Romain Harmancey (The University of Texas Health Science Center at Houston) about the study by Wentzel et al. which found that stress, expressed as a cumulative allostatic load score, impacted the microvasculature, macrovasculature, and central cardiac structure and function on a preclinical level in otherwise healthy emerging adults. The authors also found that the composite allostatic load score was particularly accurate in predicting masked hypertension and pre-diabetes in their study population. The composite allostatic load score incorporates multiple physiological biomarker systems and can offer clinicians an additional tool to use in addressing root causes of chronic stress. Is your hardware for managing stress where it should be developmentally? Listen now and learn more.   A. Wentzel, W. Smith, E. Jansen van Vuren, R. Kruger, Y. Breet, E. Wonkam-Tingang, N. A. Hanchard, and S. T. Chung Allostatic load and cardiometabolic health in a young adult South African population: the African-PREDICT study Am J Physiol Heart Circ Physiol, published February 24, 2025. DOI: 10.1152/ajpheart.00845.2024

Oncotarget
EGFR-Targeted Therapy Resistance in Breast and Head & Neck Cancers

Oncotarget

Play Episode Listen Later Jul 9, 2025 4:19


BUFFALO, NY – July 9, 2025 – A new #review was #published in Volume 16 of Oncotarget on June 25, 2025, titled “Challenges and resistance mechanisms to EGFR targeted therapies in head and neck cancers and breast cancer: Insights into RTK dependent and independent mechanisms.” Researchers from the University of Cincinnati and Cincinnati Veterans Affairs Medical Center reviewed current research on why Epidermal Growth Factor Receptor (EGFR)-targeted therapies often fail in breast and head and neck cancers. The article by Shreya Shyamsunder, Zhixin Lu, Vinita Takiar, and Susan E. Waltz explores how cancer cells evade these treatments by activating alternative survival pathways. This review offers an in-depth look at the molecular barriers to EGFR inhibition and provides insights that could inform the development of more effective and durable treatments. EGFR is a critical protein that regulates cell growth and survival, and it is frequently overexpressed in breast and head and neck cancers. Although therapies targeting EGFR showed early promise, resistance has become a significant challenge. In breast cancer, resistance mechanisms include the movement of EGFR from the cell surface into the nucleus, where it promotes DNA repair, as well as ligand-dependent activation that helps tumor growth despite therapy. In head and neck cancers, resistance often arises from inflammatory signaling through the TLR4-MyD88 pathway and the loss of tumor suppressor genes like PTEN, which allow cancer cells to bypass EGFR inhibition. The review also describes how tumor cells in both cancers commonly activate other receptor tyrosine kinases (RTKs), such as MET, AXL, and RON, to continue growing even when EGFR is blocked. By analyzing these resistance mechanisms, the authors highlight combination therapies from current research that target EGFR and other key molecular pathways. Strategies such as dual inhibition of EGFR and MET or blocking inflammation-driven survival signals may enhance treatment outcomes. Several clinical trials are evaluating these approaches in patients. For example, in breast cancer, combinations of EGFR inhibitors with chemotherapy and immune checkpoint inhibitors are being tested to improve responses, particularly in triple-negative breast cancer. In head and neck cancers, trials are investigating EGFR-blocking antibodies like cetuximab combined with immunotherapies such as pembrolizumab and nivolumab. These efforts aim to overcome resistance and provide more effective treatment options for patients with EGFR-driven tumors. The review also emphasizes the necessity of identifying biomarkers to predict which patients are most likely to benefit from EGFR-based therapies. “A recent phase 1 study has shown that patients with recurrent or metastatic head and neck cancer who received BCA101, a bifunctional dual targeting drug that targets EGFR and TGF-β in combination with pembrolizumab, were able to achieve an overall response rate of 65%.” This work brings together current knowledge about EGFR resistance and illustrates the difficulties involved in treating breast and head and neck cancers. By mapping the many ways tumors overcome EGFR inhibition, the review highlights opportunities for more tailored and effective treatments in the future. DOI - https://doi.org/10.18632/oncotarget.28747 Correspondence to - Susan E. Waltz - susan.waltz@uc.edu, and Vinita Takiar - takiarva@ucmail.uc.edu Video short - https://www.youtube.com/watch?v=RD2W-F3_aX4 About Oncotarget: Website - https://www.oncotarget.com Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Antonia Gonzales
Tuesday, July 8, 2025

Antonia Gonzales

Play Episode Listen Later Jul 8, 2025 4:59


  'Some tribal colleges will die quickly and others will die slowly'   Coulter slammed for 'ignorant', 'genocidal language' in X post   Kirkland's Senate nomination hearing for DOI post scheduled this month  

Aging-US
Abdominal Fat Linked to Reduced Strength and Mobility in Adults

Aging-US

Play Episode Listen Later Jul 8, 2025 3:31


BUFFALO, NY — July 8, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 6, on May 30, 2025, titled “Impact of waist-to-hip and waist-to-height ratios on physical performance: insights from the Longevity Check-up 8+ project.” In this study, researchers led by first author Anna Maria Martone and corresponding author Elena Levati from the Fondazione Policlinico Universitario “Agostino Gemelli” IRCCS and Università Cattolica del Sacro Cuore found that adults with higher waist-to-hip and waist-to-height ratios tend to have poorer physical performance. These simple body shape measures emerged as important tools for assessing strength and mobility, which are essential for maintaining independence as people age. The analysis included data from more than 10,000 Italian adults aged 18 to 98 years who participated in the Longevity Check-up 8+ project, a nationwide health initiative aimed at promoting healthy lifestyles and raising awareness of cardiovascular risks. Researchers measured participants' waist-to-hip (WHR) and waist-to-height (WHtR) ratios and assessed their physical function using the five-repetition chair stand test, a standard evaluation of lower body strength and mobility. “Among 10690 participants (mean age 57.0 ± 14.8 y; 54% females), men exhibited higher WHR and WHtR and a higher prevalence of abnormal values (61% and 71%).” The results showed that individuals with higher waist-to-hip and waist-to-height ratios took longer to complete the test, reflecting reduced physical function. Even after adjusting for lifestyle factors such as diet, exercise habits, and cardiovascular health, these ratios remained strongly linked to poorer performance. The waist-to-height ratio, in particular, proved to be a more effective predictor of physical ability across different age and gender groups. These findings highlight how abdominal fat, already tied to serious health risks like heart disease and diabetes, may also impair mobility and independence as people age. Monitoring waist measurements could help identify individuals at risk of functional decline, offering a simple tool to support public health in aging populations. The waist-to-height ratio is especially valuable because of its simplicity and practicality. Requiring only waist and height measurements, it can be easily used in clinical settings and community health programs to screen for potential mobility issues. Encouraging healthy waist sizes through balanced diets and regular exercise could help preserve physical performance and delay age-related decline. These findings may guide future prevention strategies. By identifying individuals at higher risk, healthcare professionals can implement targeted interventions to support long-term health and independence. DOI - https://doi.org/10.18632/aging.206260 Corresponding author - Elena Levati - elena.levati01@icatt.it Video short - https://www.youtube.com/watch?v=WqGlZ1qGZPI Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206260 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, physical performance, body composition, waist-to-hip ratio, waist-to-height ratio, chair-stand test To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

New Books Network
Rachel Killean and Lauren Dempster, "Green Transitional Justice" (Routledge, 2025)

New Books Network

Play Episode Listen Later Jul 7, 2025 69:36


In this episode, host Alex Batesmith sits down with Dr Rachel Killean and Dr Lauren Dempster to discuss their groundbreaking new book, Green Transitional Justice (Routledge, 2025). The conversation explores the urgent need to rethink transitional justice (TJ) in light of the environmental crises facing post-conflict societies. Dr Killean and Dr Dempster begin by explaining what drew them to the intersection of TJ and environmental harm. Their book emerges from a shared concern that traditional TJ mechanisms—designed to address human rights violations in post-conflict settings—have largely ignored the profound and lasting harms inflicted on Nature. They deliberately use the term “harms against Nature” to signal a shift away from anthropocentric language and to foreground the agency and value of the natural world. The book is structured around four major critiques of the TJ field. First, the authors argue that knowledge production in TJ is shaped by Eurocentric and neocolonial perspectives, often marginalising Indigenous and feminist epistemologies. They advocate for a more inclusive approach that recognises lived experience, interconnectivity, and the importance of naming environmental harm. Second, they critique the dominance of “anthropocentric legalism” in TJ—where legal frameworks and human rights discourses prioritise human victims and overlook ecological damage. This, they argue, limits the field's ability to respond meaningfully to environmental destruction. The third critique addresses how TJ mechanisms often leave structural inequalities intact. Concepts like “slow violence” and “crimes of the powerful” help illuminate how environmental harms are ongoing and systemic, not just episodic. The authors call for a shift toward transformative environmental justice, drawing on thinkers like Nancy Fraser to propose a model that includes redistribution, recognition, and representation. Finally, the book challenges the neoliberal underpinnings of TJ, particularly its alignment with economic growth and extractivism. Instead, Killean and Dempster explore alternative worldviews—buen vivir, Ubuntu, and ecological swaraj—that offer more holistic, communitarian approaches to justice. In closing, the authors outline six guiding principles for “greening” TJ, including decolonising justice, recognising non-human victimhood, and rejecting neoliberal inevitability. While acknowledging the challenges of such a radical reimagining, they remain hopeful that the field can evolve to meet the intertwined needs of people and planet. Alex Batesmith is an Associate Professor in Legal Professions in the School of Law at the University of Leeds, and a former barrister and UN war crimes prosecutor. His University of Leeds profile page can be found here Bluesky: @batesmith.bsky.social LinkedIn: https://www.linkedin.com/in/batesmith/ His recent publications include: ‘“Closeted” Cause Lawyers in Authoritarian Cambodia' (with Kieran McEvoy) Law and Society Review (2025) 1-33 DOI:10.1017/lsr.2025.29 (open access) “Cambodia and the progressivist ‘imaginary': The limitations of international(ised) criminal tribunals as mechanisms for implementing human rights” in Louisa Ashley and Nicolette Butler (eds), The Incoherence of Human Rights in International Law: Absence, Emergence and Limitations (Routledge, 2024 ISBN13: 978-1-032638-03-4) “‘Poetic Justice Products': International Justice, Victim Counter-Aesthetics, and the Spectre of the Show Trial” in Christine Schwöbel-Patel and Rob Knox (eds) Aesthetics and Counter-Aesthetics of International Justice (Counterpress, 2024 ISBN 978-1-910761-17-5) "Lawyers who want to make the world a better place – Scheingold and Sarat's Something to Believe In: Politics, Professionalism, and Cause Lawyering" in D. Newman (ed.) Leading Works on the Legal Profession (Routledge, July 2023), ISBN 978-1-032182-80-3) Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

PedsCrit
Fellowship Project Design with Dr. Mike Spaeder -- Part 1

PedsCrit

Play Episode Listen Later Jul 7, 2025 34:36


Learning Objectives:By the end of this series, listeners should be able to:Understand the research expectations of PICU Fellows in the United States.Explain the types of research available to PICU fellows and how a new fellow might explore their local options. Explain the work necessary to refine a research question and write mature specific aims for a project.  Understand the key factors involved in getting a fellowship paper submitted, including the common pitfalls for each type of research About our Guest: Mike Spaeder is a Professor of Pediatrics at the University of Virginia (UVA) School of Medicine and a pediatric critical care physician at the UVA Children's Hospital in Charlottesville, Virginia. He received his bachelor's degree in mathematics from Trinity College and his master's in statistics from George Washington University, where he also received his medical degree. He completed his pediatrics residency at Hasbro Children's Hospital/Brown University and his pediatric critical care fellowship at the Johns Hopkins Hospital. He is now the director of the Pediatric Critical Care fellowship at the UVA Children's Hospital. His research is based at the Center for Advanced Medical Analytics at the University of Virginia, where he focuses on modeling physiologic signatures of illness to identify patients at risk for clinical deterioration. Selected References:Horvat CM, Hamilton MF, Hall MW, McGuire JK, Mink RB Child Health Needs and the Pediatric Critical Care Medicine Workforce: 2020-2040. Pediatrics 2024 Feb 1 153Tasker RC. Writing for PCCM: The 3,000-Word Structured Clinical Research Report. Pediatr Crit Care Med. 2021 Mar 1;22(3):312-317.Sanchez-Pinto, L. Nelson MD, MBI1; Badke, Colleen M. MD, MS1; Pololi, Linda MBBS, FRCP (hon)2. Group Peer Mentoring: A Strategy to Promote Career Development and Improve Well-Being Among Early-Career Faculty in Pediatric Critical Care Medicine. Pediatric Critical Care Medicine ():10.1097/PCC.0000000000003763, May 15, 2025. | DOI: 10.1097/PCC.0000000000003763 Scott K. Radical Candor: Be a Kick-Ass Boss Without Losing Your Humanity. New York: St. Martin's Press; 2017. 1st ed. Equator Guidelines: https://www.equator-network.org/For Authors : Pediatric Critical Care MediQuestions, comments or feedback? Please send us a message at this link (leave email address if you would like us to relpy) Thanks! -Alice & ZacSupport the showHow to support PedsCrit:Please complete our Listener Feedback SurveyPlease rate and review on Spotify and Apple Podcasts!Donations are appreciated @PedsCrit on Venmo , you can also support us by becoming a patron on Patreon. 100% of funds go to supporting the show. Thank you for listening to this episode of PedsCrit. Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at pedscritpodcast@gmail.com. Check out http://www.pedscrit.com for detailed show notes. And visit @critpeds on twitter and @pedscrit on instagram for real time show updates.

New Books in Environmental Studies
Rachel Killean and Lauren Dempster, "Green Transitional Justice" (Routledge, 2025)

New Books in Environmental Studies

Play Episode Listen Later Jul 7, 2025 69:36


In this episode, host Alex Batesmith sits down with Dr Rachel Killean and Dr Lauren Dempster to discuss their groundbreaking new book, Green Transitional Justice (Routledge, 2025). The conversation explores the urgent need to rethink transitional justice (TJ) in light of the environmental crises facing post-conflict societies. Dr Killean and Dr Dempster begin by explaining what drew them to the intersection of TJ and environmental harm. Their book emerges from a shared concern that traditional TJ mechanisms—designed to address human rights violations in post-conflict settings—have largely ignored the profound and lasting harms inflicted on Nature. They deliberately use the term “harms against Nature” to signal a shift away from anthropocentric language and to foreground the agency and value of the natural world. The book is structured around four major critiques of the TJ field. First, the authors argue that knowledge production in TJ is shaped by Eurocentric and neocolonial perspectives, often marginalising Indigenous and feminist epistemologies. They advocate for a more inclusive approach that recognises lived experience, interconnectivity, and the importance of naming environmental harm. Second, they critique the dominance of “anthropocentric legalism” in TJ—where legal frameworks and human rights discourses prioritise human victims and overlook ecological damage. This, they argue, limits the field's ability to respond meaningfully to environmental destruction. The third critique addresses how TJ mechanisms often leave structural inequalities intact. Concepts like “slow violence” and “crimes of the powerful” help illuminate how environmental harms are ongoing and systemic, not just episodic. The authors call for a shift toward transformative environmental justice, drawing on thinkers like Nancy Fraser to propose a model that includes redistribution, recognition, and representation. Finally, the book challenges the neoliberal underpinnings of TJ, particularly its alignment with economic growth and extractivism. Instead, Killean and Dempster explore alternative worldviews—buen vivir, Ubuntu, and ecological swaraj—that offer more holistic, communitarian approaches to justice. In closing, the authors outline six guiding principles for “greening” TJ, including decolonising justice, recognising non-human victimhood, and rejecting neoliberal inevitability. While acknowledging the challenges of such a radical reimagining, they remain hopeful that the field can evolve to meet the intertwined needs of people and planet. Alex Batesmith is an Associate Professor in Legal Professions in the School of Law at the University of Leeds, and a former barrister and UN war crimes prosecutor. His University of Leeds profile page can be found here Bluesky: @batesmith.bsky.social LinkedIn: https://www.linkedin.com/in/batesmith/ His recent publications include: ‘“Closeted” Cause Lawyers in Authoritarian Cambodia' (with Kieran McEvoy) Law and Society Review (2025) 1-33 DOI:10.1017/lsr.2025.29 (open access) “Cambodia and the progressivist ‘imaginary': The limitations of international(ised) criminal tribunals as mechanisms for implementing human rights” in Louisa Ashley and Nicolette Butler (eds), The Incoherence of Human Rights in International Law: Absence, Emergence and Limitations (Routledge, 2024 ISBN13: 978-1-032638-03-4) “‘Poetic Justice Products': International Justice, Victim Counter-Aesthetics, and the Spectre of the Show Trial” in Christine Schwöbel-Patel and Rob Knox (eds) Aesthetics and Counter-Aesthetics of International Justice (Counterpress, 2024 ISBN 978-1-910761-17-5) "Lawyers who want to make the world a better place – Scheingold and Sarat's Something to Believe In: Politics, Professionalism, and Cause Lawyering" in D. Newman (ed.) Leading Works on the Legal Profession (Routledge, July 2023), ISBN 978-1-032182-80-3) Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/environmental-studies

Oncotarget
Key Genetic Alterations and Biomarker for Blastic Plasmacytoid Dendritic Cell Neoplasm

Oncotarget

Play Episode Listen Later Jul 7, 2025 3:34


BUFFALO, NY - July 7, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on June 17, 2025, titled “Genetic characteristics of blastic plasmacytoid dendritic cell neoplasm: A single institution experience.” In this study, a research team led by first author Fei Fei and corresponding author Michelle Afkhami from the City of Hope Comprehensive Cancer Center investigated a rare and aggressive type of blood cancer called blastic plasmacytoid dendritic cell neoplasm (BPDCN). Their research uncovered frequent mutations in key genes and identified CCDC50 as a potential biomarker for diagnosis and disease monitoring. These findings could help improve how this cancer is detected and treated in the future. BPDCN most often affects older adults and is known for its rapid progression and poor survival rates. The researchers performed genetic sequencing on 21 patients to better understand the disease. They found that two genes, TET2 and ASXL1, were frequently mutated in these patients and were linked to worse survival, especially in those over 65 years old. “Our study revealed that TET2 (57%) and ASXL1 (33%) were the most frequently mutated genes, followed by NRAS (29%), SRSF2 (14%), ZRSR2 (14%), and KMT2D (14%).” The study also discovered that a gene called CCDC50 was expressed at much higher levels in BPDCN samples compared to other blood cancers, such as acute myeloid leukemia and chronic monomyelocytic leukemia. This suggests that CCDC50 may help clinicians distinguish BPDCN from other similar diseases. Importantly, CCDC50 levels dropped significantly in patients whose disease went into remission, highlighting its potential as a tool for tracking disease activity over time. Researchers further observed that patients who received stem cell transplants lived longer than those who did not, reinforcing the importance of this treatment approach. However, BPDCN remains a challenging disease with an overall poor outlook, making these findings an important step toward better care. This research provides new insights into the genetic changes behind BPDCN and points to CCDC50 as a promising marker to improve diagnosis and monitor treatment success. Larger studies will be needed to confirm these results and bring these discoveries closer to use in routine medical practice. DOI - https://doi.org/10.18632/oncotarget.28742 Correspondence to - Michelle Afkhami - mafkhami@coh.org Video short - https://www.youtube.com/watch?v=wUjr3uU3onI Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28742 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, Blastic plasmacytoid dendritic cell neoplasm (BPDCN), Next-generation sequencing (NGS), CCDC50 To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

New Books in Law
Rachel Killean and Lauren Dempster, "Green Transitional Justice" (Routledge, 2025)

New Books in Law

Play Episode Listen Later Jul 7, 2025 69:36


In this episode, host Alex Batesmith sits down with Dr Rachel Killean and Dr Lauren Dempster to discuss their groundbreaking new book, Green Transitional Justice (Routledge, 2025). The conversation explores the urgent need to rethink transitional justice (TJ) in light of the environmental crises facing post-conflict societies. Dr Killean and Dr Dempster begin by explaining what drew them to the intersection of TJ and environmental harm. Their book emerges from a shared concern that traditional TJ mechanisms—designed to address human rights violations in post-conflict settings—have largely ignored the profound and lasting harms inflicted on Nature. They deliberately use the term “harms against Nature” to signal a shift away from anthropocentric language and to foreground the agency and value of the natural world. The book is structured around four major critiques of the TJ field. First, the authors argue that knowledge production in TJ is shaped by Eurocentric and neocolonial perspectives, often marginalising Indigenous and feminist epistemologies. They advocate for a more inclusive approach that recognises lived experience, interconnectivity, and the importance of naming environmental harm. Second, they critique the dominance of “anthropocentric legalism” in TJ—where legal frameworks and human rights discourses prioritise human victims and overlook ecological damage. This, they argue, limits the field's ability to respond meaningfully to environmental destruction. The third critique addresses how TJ mechanisms often leave structural inequalities intact. Concepts like “slow violence” and “crimes of the powerful” help illuminate how environmental harms are ongoing and systemic, not just episodic. The authors call for a shift toward transformative environmental justice, drawing on thinkers like Nancy Fraser to propose a model that includes redistribution, recognition, and representation. Finally, the book challenges the neoliberal underpinnings of TJ, particularly its alignment with economic growth and extractivism. Instead, Killean and Dempster explore alternative worldviews—buen vivir, Ubuntu, and ecological swaraj—that offer more holistic, communitarian approaches to justice. In closing, the authors outline six guiding principles for “greening” TJ, including decolonising justice, recognising non-human victimhood, and rejecting neoliberal inevitability. While acknowledging the challenges of such a radical reimagining, they remain hopeful that the field can evolve to meet the intertwined needs of people and planet. Alex Batesmith is an Associate Professor in Legal Professions in the School of Law at the University of Leeds, and a former barrister and UN war crimes prosecutor. His University of Leeds profile page can be found here Bluesky: @batesmith.bsky.social LinkedIn: https://www.linkedin.com/in/batesmith/ His recent publications include: ‘“Closeted” Cause Lawyers in Authoritarian Cambodia' (with Kieran McEvoy) Law and Society Review (2025) 1-33 DOI:10.1017/lsr.2025.29 (open access) “Cambodia and the progressivist ‘imaginary': The limitations of international(ised) criminal tribunals as mechanisms for implementing human rights” in Louisa Ashley and Nicolette Butler (eds), The Incoherence of Human Rights in International Law: Absence, Emergence and Limitations (Routledge, 2024 ISBN13: 978-1-032638-03-4) “‘Poetic Justice Products': International Justice, Victim Counter-Aesthetics, and the Spectre of the Show Trial” in Christine Schwöbel-Patel and Rob Knox (eds) Aesthetics and Counter-Aesthetics of International Justice (Counterpress, 2024 ISBN 978-1-910761-17-5) "Lawyers who want to make the world a better place – Scheingold and Sarat's Something to Believe In: Politics, Professionalism, and Cause Lawyering" in D. Newman (ed.) Leading Works on the Legal Profession (Routledge, July 2023), ISBN 978-1-032182-80-3) Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/law

New Books in Human Rights
Rachel Killean and Lauren Dempster, "Green Transitional Justice" (Routledge, 2025)

New Books in Human Rights

Play Episode Listen Later Jul 7, 2025 69:36


In this episode, host Alex Batesmith sits down with Dr Rachel Killean and Dr Lauren Dempster to discuss their groundbreaking new book, Green Transitional Justice (Routledge, 2025). The conversation explores the urgent need to rethink transitional justice (TJ) in light of the environmental crises facing post-conflict societies. Dr Killean and Dr Dempster begin by explaining what drew them to the intersection of TJ and environmental harm. Their book emerges from a shared concern that traditional TJ mechanisms—designed to address human rights violations in post-conflict settings—have largely ignored the profound and lasting harms inflicted on Nature. They deliberately use the term “harms against Nature” to signal a shift away from anthropocentric language and to foreground the agency and value of the natural world. The book is structured around four major critiques of the TJ field. First, the authors argue that knowledge production in TJ is shaped by Eurocentric and neocolonial perspectives, often marginalising Indigenous and feminist epistemologies. They advocate for a more inclusive approach that recognises lived experience, interconnectivity, and the importance of naming environmental harm. Second, they critique the dominance of “anthropocentric legalism” in TJ—where legal frameworks and human rights discourses prioritise human victims and overlook ecological damage. This, they argue, limits the field's ability to respond meaningfully to environmental destruction. The third critique addresses how TJ mechanisms often leave structural inequalities intact. Concepts like “slow violence” and “crimes of the powerful” help illuminate how environmental harms are ongoing and systemic, not just episodic. The authors call for a shift toward transformative environmental justice, drawing on thinkers like Nancy Fraser to propose a model that includes redistribution, recognition, and representation. Finally, the book challenges the neoliberal underpinnings of TJ, particularly its alignment with economic growth and extractivism. Instead, Killean and Dempster explore alternative worldviews—buen vivir, Ubuntu, and ecological swaraj—that offer more holistic, communitarian approaches to justice. In closing, the authors outline six guiding principles for “greening” TJ, including decolonising justice, recognising non-human victimhood, and rejecting neoliberal inevitability. While acknowledging the challenges of such a radical reimagining, they remain hopeful that the field can evolve to meet the intertwined needs of people and planet. Alex Batesmith is an Associate Professor in Legal Professions in the School of Law at the University of Leeds, and a former barrister and UN war crimes prosecutor. His University of Leeds profile page can be found here Bluesky: @batesmith.bsky.social LinkedIn: https://www.linkedin.com/in/batesmith/ His recent publications include: ‘“Closeted” Cause Lawyers in Authoritarian Cambodia' (with Kieran McEvoy) Law and Society Review (2025) 1-33 DOI:10.1017/lsr.2025.29 (open access) “Cambodia and the progressivist ‘imaginary': The limitations of international(ised) criminal tribunals as mechanisms for implementing human rights” in Louisa Ashley and Nicolette Butler (eds), The Incoherence of Human Rights in International Law: Absence, Emergence and Limitations (Routledge, 2024 ISBN13: 978-1-032638-03-4) “‘Poetic Justice Products': International Justice, Victim Counter-Aesthetics, and the Spectre of the Show Trial” in Christine Schwöbel-Patel and Rob Knox (eds) Aesthetics and Counter-Aesthetics of International Justice (Counterpress, 2024 ISBN 978-1-910761-17-5) "Lawyers who want to make the world a better place – Scheingold and Sarat's Something to Believe In: Politics, Professionalism, and Cause Lawyering" in D. Newman (ed.) Leading Works on the Legal Profession (Routledge, July 2023), ISBN 978-1-032182-80-3) Learn more about your ad choices. Visit megaphone.fm/adchoices

Vorlesungen zur Linguistik und Sprachgeschichte des Deutschen
Sendung, Ermächtigung und Verteidigung des Glaubens - wie beutet Politik religiöse Sinnstiftungsmuster und Narrative aus? (Sprache und Religion | SoSe 2025 | #174)

Vorlesungen zur Linguistik und Sprachgeschichte des Deutschen

Play Episode Listen Later Jul 6, 2025 64:05


Militärische Expansion wird in der europäischen Geschichte häufig religiös legitimiert. Doch anders, als man vermuten würde, spielt dabei nicht der Missionsbefehl des Neuen Testaments die entscheidende Rolle, sondern die Ermächtigung zur Landnahme durch die Landverheißung des Alten Testaments. In der Vorlesung nutze ich verschiedene Beispiele, um die darauf aufruhenden Argumentationsstrategien nachzuvollziehen: der Aufruf zum Kreuzzug 1095, die Ausrottung der indigenen Bevölkerung Nordamerikas durch 'christliche Amerikaner' im 18. und 19. Jahrhundert bis hin zur erzkonservativen Bewegung der Evangelikalen und christlich argumentierenden Rechtsextremisten Nordamerikas in der Gegenwart und dem russichen Angriffskrieg auf die Ukraine. Präsentation (*.pdf): Alexander Lasch. 2025. Sprache und Religion. Zenodo. DOI: ⁠⁠⁠⁠⁠⁠⁠https://doi.org/10.5281/zenodo.15175420⁠⁠⁠⁠⁠⁠⁠. Videoaufzeichnungen: ⁠⁠⁠⁠⁠⁠⁠https://youtube.com/@AlexanderLasch⁠⁠⁠⁠⁠⁠⁠. Informationen & Material zu allen Vorlesungen: ⁠⁠⁠⁠⁠⁠⁠https://kurzelinks.de/fl7f⁠⁠⁠⁠⁠⁠⁠. Worksheet zu den Vorlesungen: ⁠https://kurzlinks.de/WorksheetVorlesungen⁠. Intro: "Reflections" von Scott Holmes (CC BY via ⁠⁠⁠⁠⁠⁠FMA⁠⁠⁠⁠⁠⁠).#Linguistik #OER #Sprache #Sprachwissenschaft #Religion #Religionslinguistik

Always On EM - Mayo Clinic Emergency Medicine
Chapter 45 - Airway to Heaven: A Primer on Mechanical Ventilation for Emergency Providers

Always On EM - Mayo Clinic Emergency Medicine

Play Episode Listen Later Jul 5, 2025 73:24


Dr. Harish Kinni, a triple-board-certified emergency medicine and critical care physician and assistant professor at the Mayo Clinic, provides an overview of the fundamentals of ventilator care for emergency department professionals. We will review key modes that we should know, the variables to set, how to adjust them for your patient's needs, and provide troubleshooting tips and tricks for when things suddenly go awry. This is sure to be one of the most helpful chapters of Always on EM, but don't let it take your breath away! CONTACTS X - @AlwaysOnEM; @VenkBellamkonda YouTube - @AlwaysOnEM; @VenkBellamkonda Instagram – @AlwaysOnEM; @Venk_like_vancomycin; @ASFinch Email - AlwaysOnEM@gmail.com REFERENCES & LINKS Swart P, Nijbroek SGLH, Paulus F, Neto AS, Schultz MJ. Sex Differences in Use of Low Tidal Volume Ventilation in COVID-19-Insights From the PRoVENT-COVID Study. Front Med (Lausanne). 2022 Jan 3;8:780005. doi: 10.3389/fmed.2021.780005. PMID: 35300177; PMCID: PMC8923734. McNicholas BA, Madotto F, Pham T, Rezoagli E, Masterson CH, Horie S, Bellani G, Brochard L, Laffey JG; LUNG SAFE Investigators and the ESICM Trials Group. Demographics, management and outcome of females and males with acute respiratory distress syndrome in the LUNG SAFE prospective cohort study. Eur Respir J. 2019 Oct 17;54(4):1900609. doi: 10.1183/13993003.00609-2019. PMID: 31346004. Swart P, Deliberato RO, Johnson AEW, Pollard TJ, Bulgarelli L, Pelosi P, de Abreu MG, Schultz MJ, Neto AS. Impact of sex on use of low tidal volume ventilation in invasively ventilated ICU patients-A mediation analysis using two observational cohorts. PLoS One. 2021 Jul 14;16(7):e0253933. doi: 10.1371/journal.pone.0253933. PMID: 34260619; PMCID: PMC8279424. Evans, Laura1; Rhodes, Andrew2; Alhazzani, Waleed3; Antonelli, Massimo4; Coopersmith, Craig M.5; French, Craig6; Machado, Flávia R.7; Mcintyre, Lauralyn8; Ostermann, Marlies9; Prescott, Hallie C.10; Schorr, Christa11; Simpson, Steven12; Wiersinga, W. Joost13; Alshamsi, Fayez14; Angus, Derek C.15; Arabi, Yaseen16; Azevedo, Luciano17; Beale, Richard18; Beilman, Gregory19; Belley-Cote, Emilie20; Burry, Lisa21; Cecconi, Maurizio22; Centofanti, John23; Coz Yataco, Angel24; De Waele, Jan25; Dellinger, R. Phillip26; Doi, Kent27; Du, Bin28; Estenssoro, Elisa29; Ferrer, Ricard30; Gomersall, Charles31; Hodgson, Carol32; Hylander Møller, Morten33; Iwashyna, Theodore34; Jacob, Shevin35; Kleinpell, Ruth36; Klompas, Michael37; Koh, Younsuck38; Kumar, Anand39; Kwizera, Arthur40; Lobo, Suzana41; Masur, Henry42; McGloughlin, Steven43; Mehta, Sangeeta44; Mehta, Yatin45; Mer, Mervyn46; Nunnally, Mark47; Oczkowski, Simon48; Osborn, Tiffany49; Papathanassoglou, Elizabeth50; Perner, Anders51; Puskarich, Michael52; Roberts, Jason53; Schweickert, William54; Seckel, Maureen55; Sevransky, Jonathan56; Sprung, Charles L.57; Welte, Tobias58; Zimmerman, Janice59; Levy, Mitchell60. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. Critical Care Medicine 49(11):p e1063-e1143, November 2021. | DOI: 10.1097/CCM.0000000000005337  Fan E, Del Sorbo L, Goligher EC, Hodgson CL, Munshi L, Walkey AJ, Adhikari NKJ, Amato MBP, Branson R, Brower RG, Ferguson ND, Gajic O, Gattinoni L, Hess D, Mancebo J, Meade MO, McAuley DF, Pesenti A, Ranieri VM, Rubenfeld GD, Rubin E, Seckel M, Slutsky AS, Talmor D, Thompson BT, Wunsch H, Uleryk E, Brozek J, Brochard LJ; American Thoracic Society, European Society of Intensive Care Medicine, and Society of Critical Care Medicine. An Official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2017 May 1;195(9):1253-1263. doi: 10.1164/rccm.201703-0548ST. Erratum in: Am J Respir Crit Care Med. 2017 Jun 1;195(11):1540. doi: 10.1164/rccm.19511erratum. PMID: 28459336. Alhazzani W, Møller MH, Arabi YM, Loeb M, Gong MN, Fan E, Oczkowski S, Levy MM, Derde L, Dzierba A, Du B, Aboodi M, Wunsch H, Cecconi M, Koh Y, Chertow DS, Maitland K, Alshamsi F, Belley-Cote E, Greco M, Laundy M, Morgan JS, Kesecioglu J, McGeer A, Mermel L, Mammen MJ, Alexander PE, Arrington A, Centofanti JE, Citerio G, Baw B, Memish ZA, Hammond N, Hayden FG, Evans L, Rhodes A. Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19). Crit Care Med. 2020 Jun;48(6):e440-e469. doi: 10.1097/CCM.0000000000004363. PMID: 32224769; PMCID: PMC7176264. Wang W, Scharfstein D, Wang C, Daniels C, Needham D, Brower R, NHLBI ARDS Clinical Network. Estimating the Causal Effect of Low Tidal Volume Ventilation on Survival in Patients with Acute Lung Injury. J R Stat Soc Ser C Appl Stat. 2011. PMC: PMC3197806 Brower RG, Thompson BT, NIH/NHLBI/ARDSNetwork. Tidal volumes in acute respiratory distress syndrome--one size does not fit all. Crit Care Med. 2006. Hager DN, Krishman JA, Hayden D, Brower RG, ARDSNet NIH / NHLBI. Tidal Volume Reduction in Patients with acute Lung Injury When Plateau Pressures Are Not High. Am J Resp Crit Care Med. 2005. Rubenfeld GD, Cooper C, Carter G, Thompson BT, Hudson LD. Barriers to providing lung protective ventilation to patients with acute lung injury. Crit Care Med. 2004. Chatburn RL, El-Khatib M, Mireles-Cabodevila E. A taxonomy for mechanical ventilation: 10 fundamental maxims. Respir Care. 2014 Nov;59(11):1747-63. doi: 10.4187/respcare.03057. Epub 2014 Aug 12. PMID: 25118309. Guo L, Wang W, Zhao N, Guo L, Chi C, Hou W, Wu A, Tong H, Wang Y, Wang C, Li E. Mechanical ventilation strategies for intensive care unit patients without acute lung injury or acute respiratory distress syndrome: a systematic review and network meta-analysis. Crit Care. 2016 Jul 22;20(1):226. doi: 10.1186/s13054-016-1396-0. PMID: 27448995; PMCID: PMC4957383. Rice TW, Wheeler AP, Bernard GR, Hayden DL, Schoenfeld DA, Ware LB, NIH NHLBI ARDS Network. Comparison of the Sp02/FI02 Ratio and the PaO 2/FI02 in Patients with Acute Lung Injury or ARDS. Chest. 2007. Zhang G, Burla MJ, Caesar BB, Falank CR, Kyros P, Zucco VC, Strumilowska A, Cullinane DC, Sheppard FR. Emergency Department SpO2/FiO2 Ratios Correlate with Mechanical Ventilation and Intensive Care Unit Requirements in COVID-19 Patients. West J Emerg Med. 2024 May;25(3):325-331. doi: 10.5811/westjem.17975. PMID: 38801037; PMCID: PMC11112664.   WANT TO WORK AT MAYO? EM Physicians: https://jobs.mayoclinic.org/emergencymedicine EM NP PAs: https://jobs.mayoclinic.org/em-nppa-jobs   Nursing/Techs/PAC: https://jobs.mayoclinic.org/Nursing-Emergency-Medicine EMTs/Paramedics: https://jobs.mayoclinic.org/ambulanceservice All groups above combined into one link: https://jobs.mayoclinic.org/EM-Jobs

The Death Studies Podcast
Professor Patricia MacCormack on philosophy, death activism, veganism, antinatalism, necrosexuality, the Anthropocene, dudebros in academia, and a loving and vitalist relationship to death

The Death Studies Podcast

Play Episode Listen Later Jul 3, 2025 79:58


What's the episode about?In this episode, hear Patricia MacCormack on philosophy, death activism, veganism, antinatalism, necrosexuality, the Anthropocene, dudebros in academia, and a loving and vitalist relationship to deathWho is Patricia?Professor Patricia MacCormack is Professor of Continental Philosophy. She is the author of Cinesexuality (Routledge2008) and Posthuman Ethics (Routledge 2012) and the editorof The Animal Catalyst (Bloomsbury 2014), Deleuze andthe Animal (EUP 2017), Deleuze and the Schizoanalysis ofCinema (Continuum 2008) and Ecosophical Aesthetics (Bloomsbury 2018) and The Ahuman Manifesto: Activisms for the End of the Anthropocene. She recently completed a Leverhulme Fellow researching and developing Death Activism and completing the monograph Death Activism for Bloomsbury (2025), which we will talk about today. She is also the author of numerus journalarticles and anthology chapters and the author of fiction.  Patricia's photo is of her on Mary Wollstonecraft's former grave.How do I cite the episode in my research and reading lists?To cite this episode, you can use the following citation: MacCormack, P. (2025) Interview on The Death Studies Podcast hosted by Michael-Fox, B. and Visser, R. Published 3 July 2025. Available at: www.thedeathstudiespodcast.com, DOI: 10.6084/m9.figshare.29473577What next?Check out more episodes or find out more about the hosts! Got a question? Get in touch.

Aging-US
Longevity & Aging Series (S3, E5): Dr. Andres Cardenas

Aging-US

Play Episode Listen Later Jul 3, 2025 44:13


Dr. Andres Cardenas, from the Department of Epidemiology and Population Health at Stanford University, joins host Dr. Evgeniy Galimov to discuss a research paper he co-authored in Volume 17, Issue 2 of Aging (Aging-US), titled “Exposome-wide association study of environmental chemical exposures and epigenetic aging in the National Health and Nutrition Examination Survey.” DOI - https://doi.org/10.18632/aging.206201 Corresponding author - Andres Cardenas - andresca@stanford.edu Video interview - https://www.youtube.com/watch?v=A1I6qoVwkfM Longevity & Aging Series - https://www.aging-us.com/longevity Abstract Epigenetic clocks can serve as pivotal biomarkers linking environmental exposures with biological aging. However, research on the influence of environmental exposures on epigenetic aging has largely been limited to a small number of chemicals and specific populations. We harnessed data from the National Health and Nutrition Examination Survey 1999-2000 and 2001-2002 cycles to examine exposome-wide associations between environmental exposures and epigenetic aging. A total of 8 epigenetic aging biomarkers were obtained from whole blood in 2,346 participants ranging from 50-84 years of age. A total of 64 environmental exposures including phthalates, metals, pesticides, dioxins, and polychlorinated biphenyls (PCBs) were measured in blood and urine. Associations between log2-transformed/standardized exposure measures and epigenetic age acceleration (EAA) were assessed using survey-weighted generalized linear regression. A 1 standard deviation (SD) increase in log2 serum cadmium levels was associated with higher GrimAge acceleration (beta = 1.23 years, p = 3.63e-06), higher GrimAge2 acceleration (beta = 1.27 years, p = 1.62e-05), and higher DunedinPoAm (beta = 0.02, p = 2.34e-05). A 1 SD increase in log2 serum cotinine levels was associated with higher GrimAge2 acceleration (beta = 1.40 years, p = 6.53e-04) and higher DunedinPoAm (beta = 0.03, p = 6.31e-04). Associations between cadmium and EAA across several clocks persisted in sensitivity models adjusted for serum cotinine levels, and other associations involving lead, dioxins, and PCBs were identified. Several environmental exposures are associated with epigenetic aging in a nationally representative US adult population, with particularly strong associations related to cadmium and cotinine across several epigenetic clocks. Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206201 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, epigenetic aging, environmental exposures, exposome, epigenetics Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Aging-US
Why Big Animals Do Not Get More Cancer: Revisiting Peto's Paradox

Aging-US

Play Episode Listen Later Jul 2, 2025 4:06


BUFFALO, NY — July 2, 2025 — A new #research perspective was #published in Aging (Aging-US) Volume 17, Issue 6, on May 29, 2025, titled “Peto's paradox's relevance is off the scale.” In this perspective, Dr. Mirre J.P. Simons from the University of Sheffield argues that Peto's paradox—a well-known concept in cancer biology—remains a vital framework for understanding cancer resistance in large animals. Dr. Simons challenges recent claims that dismiss the paradox and emphasizes that the unexpectedly low cancer rates in large species still require explanation. This insight is especially relevant for aging and cancer research. Peto's paradox highlights a puzzling observation: larger animals like elephants and whales, despite having far more cells than smaller animals, do not have proportionally higher cancer rates. If each cell had an equal chance of turning cancerous, bigger animals should develop cancer much more frequently. But in reality, they do not. This suggests that evolution has equipped these animals with powerful biological defenses against cancer. “The field of comparative biology into ageing and cancer was given a strong impetus when Peto identified that humans have substantially more cells than mice, but do not have substantially larger incidence of cancer.” Dr. Simons explains that recent studies showing small increases in cancer with body size do not disprove the paradox. The expected increase, based on basic mathematical models, would be massive—many times greater than what is observed. Instead of rejecting Peto's paradox, the field should focus on understanding how large animals suppress cancer so effectively. The author points out that the key to resolving this paradox may lie in traits that evolved alongside body size, such as tissue environments or specialized cell-control mechanisms. These features might reduce the probability of cancer developing, even in animals with millions or billions more cells than humans. Importantly, this perspective underscores the clinical potential of studying species that resist cancer naturally. Studying these natural defenses may help researchers uncover new ways to understand, prevent, or manage cancer. Because cancer risk increases with age in most species, understanding how some animals limit both aging and cancer may also help explain how these two processes are connected. Dr. Simons cautions against oversimplifying cancer biology by focusing only on genetic mutations. Instead, understanding how cells interact with their environment, known as the tissue microenvironment, may offer deeper insight into how cancer develops or is prevented. By reaffirming the importance of Peto's paradox, this research perspective encourages the scientific community to explore the evolutionary tools nature uses to fight cancer. These insights could improve our understanding of cancer and inspire new strategies to support healthier aging. DOI - https://doi.org/10.18632/aging.206258 Corresponding author - Mirre J.P. Simons - m.simons@sheffield.ac.uk Video short - https://www.youtube.com/watch?v=sDaq07zX2TM Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206258 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, cancer, evolution To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Herpetological Highlights
231 Hotter Times for Desert Lizards

Herpetological Highlights

Play Episode Listen Later Jul 1, 2025 28:04


A monumental new study has addressed the likely impacts of climate change on the activity of desert lizards in Africa and Australia. Hotter temperatures will likely ‘squeeze' the activity window of some lizards, especially those active during the day. We chat about the ramifications of this paper, before turning to news of dogs being attacked by anacondas. Become a Patreon: https://www.patreon.com/herphighlights Merch: https://www.redbubble.com/people/herphighlights/shop Full reference list available here: http://www.herphighlights.podbean.com Main Paper References: Wild KH, Huey RB, Pianka ER, Clusella-Trullas S, Gilbert AL, Miles DB, Kearney MR. 2025. Climate change and the cost-of-living squeeze in desert lizards. Science 387:303–309. DOI: 10.1126/science.adq4372. Other Mentioned Papers/Studies: Starace, F., & Ineich, I. (2025). Predation on dogs by Green Anacondas, Eunectes murinus (Linnaeus, 1758): two cases from French Guiana. Herpetology Notes, 18, 415-419. Other Links/Mentions: Rhinella alata call from James LS, O'Mara MT, Touchon JC, Ryan MJ, Bernal XE, Page RA. 2025. The ontogeny of decision-making in an eavesdropping predator. Proceedings of the Royal Society B: Biological Sciences 292:20250450. DOI: 10.1098/rspb.2025.0450. AmphibiaWeb - Rhinella alata. Available at https://amphibiaweb.org/cgi/amphib_query?where-scientific_name=Rhinella+alata&rel-scientific_name=contains&include_synonymies=Yes (accessed June 19, 2025). Editing and Music: Intro/outro – Treehouse by Ed Nelson Species Bi-week theme – Michael Timothy Other Music – The Passion HiFi, https://www.thepassionhifi.com

Everything Hertz
192: Outsourcing in academia

Everything Hertz

Play Episode Listen Later Jul 1, 2025 47:42


Dan and James answer listener questions on outsourcing in academia and differences in research culture between academic institutions and commercial institutions. Social media links - Dan on Bluesky (https://bsky.app/profile/dsquintana.bsky.social) - James on Bluesky (https://bsky.app/profile/jamesheathers.bsky.social) - Everything Hertz on Bluesky (https://bsky.app/profile/hertzpodcast.bsky.social) Citation Quintana, D. S., & Heathers, J. (2025, July 1). 192: Outsourcing in academia, Everything Hertz [Audio podcast], DOI: 10.17605/OSF.IO/3MC2R

The Future of Insurance
The Future of Insurance – Chris Meredith, Candidate for OK Insurance Commissioner

The Future of Insurance

Play Episode Listen Later Jul 1, 2025 16:27


Episode Info Chris Merideth is a seasoned insurance industry professional, public policy strategist, and Republican candidate for Oklahoma Insurance Commissioner in 2026. With a career spanning agency operations, catastrophe response, and legislative advocacy, Chris brings a rare 360-degree view of the insurance ecosystem—having worked with agents, adjusters, consumers, and lawmakers from across the country. Currently serving in government affairs for a major national carrier, Chris has been on the front lines of some of the most pressing issues facing the market: skyrocketing premiums, litigation abuse, disappearing availability, and the urgent need for property resilience in a high-risk state like Oklahoma. Chris's campaign is built on grassroots leadership, free-market reform, and a clear promise: make insurance work for people again. His bold policy agenda includes reducing reinsurance pressure, incentivizing fortified home construction, streamlining regulatory red tape, and launching transparency tools like a Prior Authorization Report Card and a Claims Complaint Scoreboard. Known for his energy, grit, and straight talk, Chris is leading a grassroots movement of agents and consumers to restore trust and accountability in the insurance system—before it's too late. Follow his campaign at www.ChrisMeridethForOK.com Episode Summary The video features a conversation with Chris Meredith, a candidate running for the position of Commissioner of Insurance in Oklahoma. The discussion centers around the challenges and solutions related to insurance and fortified homes in the state. Here are the key points covered in the video: Background and Motivation: Chris emphasizes that their campaign is not about politics but about protecting people and doing the right thing. He has extensive experience in the insurance industry, having worked across various states and attended national meetings. Insurance Challenges: There is a nationwide issue with insurance affordability, where people struggle to afford insurance, and carriers find it economically challenging to provide coverage. The frequency and severity of storms, particularly hailstorms, are increasing, making it more likely for homes to be hit. Fortified Homes Initiative: Chris advocates for fortified homes, which are designed to withstand severe weather conditions. This includes using hail-resistant shingles and securing roof decking. They highlight the success of similar programs in Alabama and stress the need for Oklahoma to adopt these best practices. Legislative and Grassroots Efforts: Chris discusses the importance of legislative changes and grassroots efforts to push for fortified home initiatives. He emphasizes collaboration over conflict, urging local agents, roofers, and contractors to work together to influence legislative priorities. Future Plans and Commitment: Chris is committed to implementing these initiatives if elected, drawing on private funding and legislative support. He expresses a personal connection to the cause, having witnessed the impact of insurance in disaster recovery. OverallOverall, the interviedw highlights Chris's vision for improving insurance practices in Oklahoma through fortified homes and collaborative efforts. This episode is brought to you by The Future of Insurance book series (future-of-insurance.com) from Bryan Falchuk. Follow the podcast at future-of-insurance.com/podcast for more details and other episodes. Music courtesy of Hyperbeat Music, available to stream or download on Spotify, Apple Music, and Amazon Music and more.

Oncotarget
New Drug Combination Redefines First-Line Treatment for Advanced Urothelial Cancer

Oncotarget

Play Episode Listen Later Jul 1, 2025 3:38


BUFFALO, NY – July 1, 2025 – A new #review was #published in Volume 16 of Oncotarget on June 17, 2025, titled “Optimizing enfortumab vedotin plus pembrolizumab therapy.” First authors Elias Antoine Karam of the Gustave Roussy and Saint-Joseph University of Beirut and Yaghi César Céline from the Saint-Joseph University of Beirut, along with their colleagues, reviewed recent developments about treating advanced urothelial carcinoma (aUC), an aggressive form of bladder cancer. Their review highlights how combining enfortumab vedotin and pembrolizumab as a first-line treatment offers a major improvement for patients with limited options and poor prognoses. Advanced urothelial cancer has traditionally been treated with platinum-based chemotherapy, which often causes serious side effects and offers limited long-term benefit. Many patients are even ineligible for it due to underlying health conditions. The new combination presents a more effective and better-tolerated alternative, as shown in recent clinical trials reviewed by the authors. Enfortumab vedotin targets Nectin-4, a protein present in most urothelial cancer cells, delivering a cancer-killing agent directly into tumors. Pembrolizumab helps the immune system detect and destroy cancer cells. Together, they have shown strong results in extending survival with fewer serious side effects than chemotherapy. These findings led to FDA approval in 2023 for use in a broad range of patients, including those unable to tolerate traditional treatments. “In the phase II KEYNOTE-052 study, pembrolizumab demonstrated significant efficacy as initial therapy in patients with aUC who were ineligible for a cisplatin-based regimen.” The review also compares this new approach with other evolving strategies, such as therapies using nivolumab and chemotherapy combinations. Among current first-line options, enfortumab vedotin and pembrolizumab have produced the most promising outcomes. However, the best course of action following disease progression remains unclear. Other important challenges raised in the review include the high cost of the new therapies, limited patient access to them, and the absence of reliable biomarkers to predict individual response. The authors call for further studies to refine treatment strategies and explore blood-based tools that could guide therapy decisions and minimize side effects. This review offers a clear summary of how recent clinical advances are reshaping the treatment of aUC. It reflects a shift away from traditional chemotherapy toward immunotherapy and targeted, personalized treatments that aim to extend survival and improve quality of life. DOI - https://doi.org/10.18632/oncotarget.28741 Correspondence to - Elias Antoine Karam - eliaskaram18@gmail.com Video short - https://www.youtube.com/watch?v=VrTXaF2qW2k Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28741 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, advanced urothelial carcinoma (aUC), enfortumab vedotin, pembrolizumab, treatment strategies, bladder cancer To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Aging-US
New Lipid-Based Aging Clock Reveals Faster Brain Aging in Autism, Schizophrenia, and Down Syndrome

Aging-US

Play Episode Listen Later Jul 1, 2025 4:17


BUFFALO, NY — July 1, 2025 — A new #research paper, featured on the #cover of Aging (Aging-US) Volume 17, Issue 6, was #published on June 4, 2025, titled “DoliClock: a lipid-based aging clock reveals accelerated aging in neurological disorders.” This study, led by first author Djakim Latumalea from the National University of Singapore and Hanze University of Applied Sciences, with corresponding author Brian K. Kennedy from the National University of Singapore, introduces DoliClock, a biological aging clock based on lipid profiles in the human brain. The researchers found that individuals with autism, schizophrenia, and Down syndrome show signs of accelerated brain aging compared to individuals without these conditions. The discovery offers a new approach to measuring brain aging using lipid markers instead of traditional DNA-based methods. The team developed DoliClock using lipidomic data from post-mortem prefrontal cortex samples. Lipids are fat-like molecules that play a key role in brain health. Changes in lipid patterns can reflect the biological age of brain tissue. The study focused on a specific class of lipids called dolichols, which increase gradually with age. The DoliClock model was trained to predict biological age by analyzing levels of dolichols and other lipid molecules. It accurately estimated brain age and revealed higher aging rates in individuals with neurological disorders. One notable finding was a sharp increase in lipid profile variability—also known as entropy—around the age of 40. This suggests a disruption in lipid metabolism during midlife, possibly caused by changes in the mevalonate pathway, a critical biological process involved in producing lipids like cholesterol and dolichol. These disruptions may contribute to aging-related brain decline. The study also found that dolichol levels could serve as reliable biomarkers of aging. Their consistent increase with age and strong influence on DoliClock's predictions make them especially useful. In individuals with autism, schizophrenia, and Down syndrome, the clock indicated more advanced biological brain aging than expected, supporting the idea that these conditions are associated with premature aging. DoliClock offers a new perspective in aging research, complementing existing biological clocks based on DNA or protein markers. Because it relies on lipids, it may detect aspects of aging that other tools cannot. While the current model is based on brain tissue samples, future research may examine whether similar lipid patterns can be identified in more accessible fluids such as blood or cerebrospinal fluid. “These findings suggest that lipidomics can provide valuable insights into the molecular mechanisms of brain aging and neurological disorders.” This study highlights the growing potential of lipidomics in the study of aging and neurological disorders. It opens the door to new biomarkers that could help researchers and clinicians better monitor brain aging and develop more targeted interventions for age-related and neurodevelopmental diseases. DOI - https://doi.org/10.18632/aging.206266 Corresponding author - Brian K. Kennedy - bkennedy@nus.edu.sg Video short - https://www.youtube.com/watch?v=-FEiyj9PjBE Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Let's talk e-cigarettes
Let's talk e-cigarettes, June 2025

Let's talk e-cigarettes

Play Episode Listen Later Jun 30, 2025 17:30


Jamie Hartmann-Boyce and Nicola Lindson interview Lauren McMillan, University of Stirling about her project evaluating the effectiveness of an e-cigarette intervention for smoking cessation at centres for people experiencing or at risk of homelessness. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Lauren McMillan from the Institute for Social Marketing and Health (ISMH) at the University of Stirling. In the June podcast Lauren discusses Project SCeTCH - a cluster RCT that evaluates the effectiveness of an e-cigarette intervention vs usual care at centres for people experiencing or at risk of homelessness. The study measures smoking abstinence over a 6 month follow-up period and includes embedded process and economic evaluations. If effective, the results will be used to inform the larger-scale implementation of offering e-cigarettes throughout centres for people experiencing or at risk of homelessness to aid smoking cessation. Lauren is part of the research team, led by Dr Allison Ford at the University of Stirling, that conducted the process evaluation of the SCeTCH trial . The main SCeTCH trial was led by Professor Lynne Dawkins (London Southbank University) and Dr Sharon Cox (University College London). This podcast is a companion to the electronic cigarettes Cochrane living systematic review and Interventions for quitting vaping review and shares the evidence from the monthly searches. Our search for the EC for smoking cessation review carried out on 1st June 2025 found 1 ongoing study: https://clinicaltrials.gov/study/NCT06948058 Our search for our interventions for quitting vaping review up to 1st June 2025 found 2 new (DOI 10.1093/ntr/ntaf112; 10.1016/j.amepre.2025.107664) and 2 linked papers (DOI: 10.2196/72002; 10.1016/j.cct.2025.107958) For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review of E-cigarettes for smoking cessation updated in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub9/full For more information on the full Cochrane review of Interventions for quitting vaping published in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD016058.pub2/full This podcast is supported by Cancer Research UK.

Herpetological Highlights
230 Bats Listen to Hear Which Frog is Tastiest

Herpetological Highlights

Play Episode Listen Later Jun 29, 2025 31:59


Bats have famously good hearing, and fringe-lipped bats in Panama have tuned theirs to listen out for frogs calling out for mates. But these bats are quite particular about which amphibians they eat. New research has revealed that bats have to learn these skills, as the youngsters have way less idea which frogs they can safely tackle. We finish off talking about a newly described skink from urban China. Become a Patreon: https://www.patreon.com/herphighlights Merch: https://www.redbubble.com/people/herphighlights/shop Full reference list available here: http://www.herphighlights.podbean.com Main Paper References: James LS, O'Mara MT, Touchon JC, Ryan MJ, Bernal XE, Page RA. 2025. The ontogeny of decision-making in an eavesdropping predator. Proceedings of the Royal Society B: Biological Sciences 292:20250450. DOI: 10.1098/rspb.2025.0450. Species of the Bi-Week: Jia R-W, Gao Z-Y, Wu D-H, Wang G-Q, Liu G, Liu M, Jiang K, Jiang D-C, Ren J-L, Li J-T. 2025. Hidden Urban Biodiversity: A New Species of the Genus Scincella Mittleman, 1950 (Squamata: Scincidae) from Chengdu, Sichuan Province, Southwest China. Animals 15:232. DOI: 10.3390/ani15020232. Editing and Music: Intro/outro – Treehouse by Ed Nelson Species Bi-week theme – Michael Timothy Other Music – The Passion HiFi, https://www.thepassionhifi.com

Communicable
Communicable E30: WHO's first-ever guideline on meningitis

Communicable

Play Episode Listen Later Jun 29, 2025 60:57


Meningitis remains a major global health threat, with an estimated 2.5 million cases each year; of these, one in six results in death and one in five in long-term disabilities. Although meningitis “can strike anyone, anywhere in the world,” outbreaks disproportionately impact low- and middle-income countries, where diagnostic and treatment resources are limited. In efforts to address this, WHO launched its first-ever guideline on meningitis diagnosis and management in April this year. In this episode of Communicable, hosts Emily McDonald and Marc Bonten are joined by two experts directly involved in creating the guideline, Lorenzo Pezzoli and Nicolò Binello (WHO), as well as Jacob Bodilsen (Aalborg University), clinician-researcher and Chair of ESCMID's Study Group for Infectious Diseases of the Brain (ESGIB). The guests offer a firsthand look behind the guideline's development, review key recommendations for diagnosis and treatment - including the use of lumbar puncture, antibiotics, and chemoprophylaxis – and discuss how these fit into various clinical settings. This episode was edited by Kathryn Hostettler and peer reviewed by Ljiljana Lukić of University Hospital for Infectious Diseases in Zagreb, Croatia. The executive producer of Communicable is Angela Huttner. TermsCRP, C-reactive proteinGDG, Guideline Development GroupLiterature WHO guidelines on meningitis diagnosis, treatment and care. April 2025. https://www.who.int/publications/i/item/9789240108042Defeating meningitis by 2030: a global road map. June 2021. https://www.who.int/publications/i/item/9789240026407Olie SE, et al. Validation and clinical implementation of cerebrospinal fluid C-reactive protein for the diagnosis of bacterial meningitis: a prospective diagnostic accuracy study. Lancet Reg June 2025. DOI: 10.1016/j.lanepe.2025.101309Coldiron ME, et al. Single-dose oral ciprofloxacin prophylaxis as a response to a meningococcal meningitis epidemic in the African meningitis belt: A 3-arm, open-label, cluster-randomized trial. PloS Med 2018. DOI: 10.1371/journal.pmed.1002593Hasbun R, et al. Computed tomography of the head before lumbar puncture in adults with suspected meningitis. N Engl J Med 2001. DOI: 10.1056/NEJMoa010399Glimåker M. Lumbar puncture in adult bacterial meningitis: time to reconsider guidelines? BMJ 2013, DOI: 10.1136/bmj.f361

Vorlesungen zur Linguistik und Sprachgeschichte des Deutschen
Scheitern im Sakramentsvollzug: Sprechhandlungen in der Taufe (Sprache und Religion | SoSe 2025 | #173)

Vorlesungen zur Linguistik und Sprachgeschichte des Deutschen

Play Episode Listen Later Jun 28, 2025 71:52


Eine wichtige Überlegung in der Pragmatik ist die, dass Sprechhandlungen scheitern können. In "Exempel I" beobachten wir genau das am Vollzug des Sakramentes der christlichen Taufe im Hinblick auf den Sprechhandlungscharakter von Sprache. Präsentation (*.pdf): Alexander Lasch. 2025. Sprache und Religion. Zenodo. DOI: ⁠⁠⁠⁠⁠⁠⁠https://doi.org/10.5281/zenodo.15175420⁠⁠⁠⁠⁠⁠⁠. Videoaufzeichnungen: ⁠⁠⁠⁠⁠⁠⁠https://youtube.com/@AlexanderLasch⁠⁠⁠⁠⁠⁠⁠. Informationen & Material zu allen Vorlesungen: ⁠⁠⁠⁠⁠⁠⁠https://kurzelinks.de/fl7f⁠⁠⁠⁠⁠⁠⁠. Worksheet zu den Vorlesungen: ⁠https://kurzlinks.de/WorksheetVorlesungen⁠. Intro: "Reflections" von Scott Holmes (CC BY via ⁠⁠⁠⁠⁠⁠FMA⁠⁠⁠⁠⁠⁠).#Linguistik #OER #Sprache #Sprachwissenschaft #Religion #Religionslinguistik

Oncotarget
HER2-Mutated NSCLC in Brazil Shows Diverse Genetic Patterns and Treatment Gaps

Oncotarget

Play Episode Listen Later Jun 27, 2025 4:35


BUFFALO, NY – June 27, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on June 17, 2025, titled “Molecular landscape of HER2-mutated non-small cell lung cancer in Northeastern Brazil: Clinical, histopathological, and genomic insights.” In this study, researchers led by first authors Cleto Dantas Nogueira from the Federal University of Ceará and Argos Pathology Laboratory and Samuel Frota from Argos Pathology Laboratory, along with corresponding author Fabio Tavora from the previously mentioned institutions and Messejana Heart and Lung Hospital, investigated how HER2 gene mutations appear in cases of non-small cell lung cancer (NSCLC) in Northeastern Brazil. The team found that HER2 mutations showed significant genetic diversity and were often associated with other cancer-related genetic changes. These findings revealed diagnostic and treatment challenges in a population that is rarely studied, emphasizing the need for expanded access to molecular testing and targeted therapies. HER2 mutations are a known factor in several cancers, including breast and gastric cancers. In lung cancer—particularly NSCLC—these mutations are less common but remain clinically significant. Most existing research on HER2-mutated lung cancer focuses on high-income countries, leaving important gaps in knowledge about underrepresented regions such as Latin America. This study helps fill that gap by analyzing 13 patients with HER2-mutated NSCLC using clinical, pathological, and genomic data. The patients ranged in age from 34 to 82 years, and more than half were women. About half had never smoked. Their tumors often displayed complex genetic profiles, including additional mutations in genes such as TP53, KRAS, and STK11. The most common HER2 mutation identified was an insertion in exon 20, a known hotspot for activating mutations. “Trastuzumab deruxtecan (T-DXd) is the first HER2-targeted agent to show clinical efficacy in HER2-mutant non-small cell lung cancer (HER2m NSCLC).” Treatment strategies among the patients varied. Only one individual received HER2-targeted therapy. Most were treated with surgery, chemotherapy, immunotherapy, or a combination of these approaches. Outcomes also differed, with some patients surviving for years and others dying within months of diagnosis. These findings reinforce the need for early diagnosis and improved access to advanced treatments, particularly in low-resource settings. The study emphasizes the value of comprehensive molecular profiling in NSCLC. Because HER2 mutations often occur alongside other genetic alterations, full genomic analysis is crucial for guiding treatment decisions. Yet, such testing is not always available. The researchers propose a tiered diagnostic approach, beginning with basic screening and expanding to more advanced tests when necessary, to enhance patient care. This study provides valuable insights into the molecular characteristics of HER2-mutated NSCLC in a Brazilian population, highlighting the complexity and clinical relevance of these alterations. Larger studies are needed to clarify the prevalence and prognostic significance of HER2 mutations, as well as their impact on treatment response and survival. This knowledge is essential for advancing effective HER2-targeted therapies. The findings also support broader implementation of international clinical guidelines in Latin America and highlight the critical need to include underrepresented populations in cancer research. DOI - https://doi.org/10.18632/oncotarget.28737 Correspondence to - Fabio Tavora - stellacpak@outlook.com Video short - https://www.youtube.com/watch?v=hr5R9iDBFFI To learn more about Oncotarget, please visit https://www.oncotarget.com. MEDIA@IMPACTJOURNALS.COM

Fain & Simplu Podcast
DECONSPIRAREA MUZICII ROMÂNEȘTI DIN ULTIMII 30 ANI, CU ”TATĂL” Ei, RADU FORNEA | Fain & Simplu 256

Fain & Simplu Podcast

Play Episode Listen Later Jun 26, 2025 192:01


Mihai Morar ne duce înapoi în timp, în România anilor '90, alături de cel care a făcut cadrul pentru scena muzicală de azi: Radu Fornea.A fost vecin cu un medic celebru în toată lumea, care i-a schimbat viața. A oscilat între mai multe posibile cariere strălucite – neurochirurgie, producție de roboți, jurnalism – dar a ales lucrul la care nici nu se gândea ca adolescent. Muzica! Și a dus-o la alt nivel. Pentru că Radu Fornea este cel care are la activ hit-uri cu peste 100 de artiști diferiți! Nume care au dominat scena românească post '89, care au impus stiluri și au schimbat, pentru totdeauna, societatea noastră.Ești curios să afli câți bani a făcut din muzică omul identificat cu Proiect K1 și stilul etno? Care au fost dedesubturile momentului în care hit-urile unei noi lumi au înlocuit șlagarele artiștilor de ieri? Cine sunt oamenii care au inițiat stiluri și proiecte mari azi? Și, mai ales, cum a apărut cadrul legal care permite artiștilor de azi să câștige zeci de mii de euro, de la cei 500 de dolari, cât era plătită o trupă pe val în anii de după Revoluție?  Nu rata o discuție ca o călătorie în timp! Către vremurile mai simple, mai nereglementate, mai pline de speranță, în care luxul, pentru români, înseamna un telefon cu clapetă și un Cielo!Și află, dacă nu știai deja, despre cel mai inedit festival autohton: Unforgetable Festival, cel mai mare festival cu locuri pe scaune. Găzduit în perioda 11 – 13 septembrie de București. Realizat de Radu Fornea și prezentat de Mihai Morar. Doi oameni de media și muzică ce inversează azi rolurile, la Fain & Simplu.

Stuff You Missed in History Class
Rosina Bulwer-Lytton's Blighted Life (Part 2)

Stuff You Missed in History Class

Play Episode Listen Later Jun 25, 2025 41:10 Transcription Available


Once Rosina Bulwer-Lytton and her husband Edward separated, his life seemed to become more and more successful while she struggled with finances. The estranged couple then spent years battling very publicly until Edward had Rosina committed. Research: “A Scene at the Hertfordshire Election.” The Tiverton Gazette. 6/29/1858. https://www.newspapers.com/image/803824054/ Blain, Virginia. “Rosina Bulwer Lytton and the Rage of the Unheard.” Huntington Library Quarterly , Summer, 1990, Vol. 53, No. 3. Via JSTOR. https://www.jstor.org/stable/3817439 Brown, Andrew. "Lytton, Edward George Earle Lytton Bulwer [formerly Edward George Earle Lytton Bulwer], first Baron Lytton (1803–1873), writer and politician." Oxford Dictionary of National Biography. September 23, 2004. Oxford University Press. Date of access 4 Jun. 2025, https://www-oxforddnb-com.proxy.bostonathenaeum.org/view/10.1093/ref:odnb/9780198614128.001.0001/odnb-9780198614128-e-17314 Bulwer-Lytton, Rosina. “Lady Bulwer Lytton's Appeal to the Justice and Charity of the English Public.” By and For the Author. 1857. Devey, Louisa, editor. “Letters of the late Edward Bulwer, lord Lytton, to his wife.” New York : G. W. Dillingham. 1889. Devey, Louisa. “Life of Rosina, Lady Lytton: With Numerous Extracts from Her Ms. Autobiography and Other Original Documents.” London, Swan Sonnschein, Lowery & Co. 1887. Flynn, Michael J. “Dickens, Rosina Bulwer Lytton, and the ‘Guilt’ of Literature and Art.” Dickens Quarterly, March 2012, Vol. 29, No. 1 (March 2012). Via JSTOR. https://www.jstor.org/stable/45292582 King, Cornelia. “Getting Even: The Mighty Pen of Lady Bulwer Lytton.” The Library Company of Philadelphia. 5/10/2022. https://librarycompany.org/2022/05/10/getting-even/ Latané, D.E. “Edward Bulwer Lytton’s committal of his wife Rosina to a private mental asylum in 1858.” Victorian Web. https://victorianweb.org/authors/bulwer/latane.html McFadden, Margaret. “Anna Doyle Wheeler (1785-1848): Philosopher, Socialist, Feminist.” Hypatia, vol. 4, no. 1, 1989, pp. 91–101. JSTOR, http://www.jstor.org/stable/3809936. Accessed 3 June 2025. Mulvey-Roberts, Marie. "Fame, notoriety and madness: Edward Bulwer-Lytton paying the price of greatness." Critical Survey, vol. 13, no. 2, May 2001, pp. 115+. Gale Literature Resource Center, link.gale.com/apps/doc/A80191856/LitRC?u=mlin_n_melpub&sid=bookmark-LitRC&xid=2669a158. Accessed 27 May 2025. Mulvey-Roberts, Marie. "Lytton, Rosina Anne Doyle Bulwer [née Rosina Anne Doyle Wheeler], Lady Lytton (1802–1882), novelist." Oxford Dictionary of National Biography. October 08, 2009. Oxford University Press. Date of access 28 May. 2025, https://www-oxforddnb-com.proxy.bostonathenaeum.org/view/10.1093/ref:odnb/9780198614128.001.0001/odnb-9780198614128-e-17316 Mulvey-Roberts, Marie. “‘The Very Worst Woman I Ever Heard of’: Rosina Bulwer Lytton and Biography as Vindication.” Women's Writing, 25:2, 253-267, DOI: 10.1080/09699082.2017.1387338 See omnystudio.com/listener for privacy information.

Baby Or Bust
Ep 129 Fewer Shots, Same Success: A New IVF Protocol with Dr. Linnea Goodman

Baby Or Bust

Play Episode Listen Later Jun 24, 2025 38:27


What if IVF didn't have to mean so many shots? Could a new protocol allow for fewer shots, less office visits, AND be less expensive?  In this episode of Brave & Curious, Dr. Lora Shahine is joined by Dr. Linnea Goodman to answer these questions and more. They review Dr. Goodman's research into a protocol, not new to the fertility field around the world, but new to most listeners in the United States that has many benefits to IVF patients. Dr. Linnea Goodman is a board-certified reproductive endocrinologist and infertility specialist. Throughout her career, Dr. Goodman has been dedicated to advancing the field of reproductive medicine through both clinical excellence and innovative research. Currently, Dr. Goodman practices at Virginia Fertility & IVF, where she specializes in minimally invasive office procedures aimed at optimizing fertility outcomes. In this episode you'll hear: [1:16] Meet Dr. Linnea Goodman: reproductive endocrinologist and researcher [2:24] IVF shots & their necessity [4:45] Provera Protocol is a game-changer [14:35] Research & evidence for the Provera Protocol  [22:19] A patient-centered approach [25:00] Research Outcomes [27:07] Innovations in IVF: Progestins [29:32 The patient experience: benefits and side effects of progestins [32:36 What does the future hold?  Resources mentioned:  http://vafertility.com Massin N, et al. New stimulation regimens: endogenous and exogenous progesterone use to block the LH surge during ovarian stimulation for IVF. Hum Reprod Update. 2017 Mar 1;23(2):211-220. doi: 10.1093/humupd/dmw047.PMID: 28062551  R Beguería, et al. Medroxyprogesterone acetate versus ganirelix in oocyte donation: a randomized controlled trial. Hum Reprod. 2019 May 1;34(5):872-880 doi:10.1093/humrep/dez034. PMID: 30927417 Giles J, et al. Medroxyprogeseterone acetate is a useful alternative to a gonadotropin-releasing hormone antagonist in ooxyte-donation: a randomized controlled trial. Fert Stert 2021;116: 404-412. PMID: 33814126. DOI: 10.1016/j.fertnstert.2021.02.036 Welp A, et al. Oral medroxyprogesterone acetate for the use of ovulation suppression in in vitro fertilization: a cohort trial. Fertil Steril 2024 May;121(5):806-813. PMID: 38253117 DOI: 10.1016/j.fertnstert.2024.01.026   Dr. Shahine's Weekly Newsletter on Fertility News and Recommendations Follow @drlorashahine Instagram | YouTube | Tiktok | Her Books

Oncotarget
WIN International Molecular Tumor Board Recommends Tailored Treatment for Advanced Colorectal Cancer

Oncotarget

Play Episode Listen Later Jun 24, 2025 4:40


BUFFALO, NY – June 24, 2025 – A new precision #oncology paper was #published in Volume 16 of Oncotarget on June 17, 2025, titled “Case Report WIN-MTB-2023001 WIN International Molecular Tumor Board A 62-year-old male with metastatic colorectal cancer with 5 prior lines of treatment.” In this report, led by Alberto Hernando-Calvo from Vall d'Hebron University Hospital and Vall d'Hebron Institute of Oncology; Razelle Kurzrock from WIN Consortium and Medical College of Wisconsin; Oncotarget Editor-in-Chief Wafik S. El-Deiry from WIN Consortium and Legorreta Cancer Center at Brown University; and corresponding author Shai Magidi, also from WIN Consortium, along with colleagues, describe the case of a 62-year-old man with metastatic colorectal cancer who underwent multiple lines of therapy. After analysis, the WIN International Molecular Tumor Board proposed different personalized treatment plans based on the tumor's unique genetic mutations. This case highlights the growing role of precision oncology in guiding therapies for patients with treatment-resistant cancers. Colorectal cancer is one of the deadliest cancers worldwide, and managing advanced cases remains a significant challenge. This patient had already received five prior treatment regimens, including chemotherapy and targeted therapies. Although some treatments were initially beneficial, the cancer eventually developed resistance. Molecular analysis revealed key mutations in genes such as BRAF, MET, APC, TP53, and NRAS, which are often linked to aggressive tumor behavior and reduced treatment effectiveness. With limited standard options left, the patient's case was presented and reviewed by the WIN International Molecular Tumor Board, a global panel of cancer experts. The team analyzed the clinical history and genetic profile to design new treatment approaches. These involved off-label drug combinations tailored to the specific mutations found in the tumor. For example, one approach combined trametinib, a drug that blocks cancer cell growth signals, with amivantamab, an antibody that attacks cancer-related proteins MET and EGFR, and regorafenib, which helps cut off blood supply to tumors and may counteract effects from APC and TP53 mutations. “Another option was trametinib at 1 mg daily, cetuximab (EGFR antibody), 250 mg/m² IV every two-weeks, and cabozantinib (MET and VEGFR inhibitor), 40 mg po daily.” This case reflects a shift in cancer care from standardized protocols to precision approaches, where therapy is selected based on a tumor's molecular features. Such strategies aim to delay resistance and slow disease progression more effectively. The WIN International Molecular Tumor Board also discussed practical challenges, including access to medications, combining off-label drugs, and the difficulties of enrolling patients in clinical trials after multiple prior treatments. Although the ultimate treatment decision remained with the patient's physician, this report shows how international collaboration and precision oncology can expand options for patients facing limited alternatives. It also emphasizes the value of repeat genetic analysis during disease progression to monitor new mutations in the tumor that may impact treatment. While the patient ultimately died from cancer progression, this case serves as a model for how molecular analysis and expert input can be used to guide treatment even in complex and metastatic colorectal cancer. As personalized cancer strategies continue to evolve, they may offer potential pathways for patients who have exhausted standard treatment options. DOI - https://doi.org/10.18632/oncotarget.28744 Correspondence to - Shai Magidi - shai.magidi@winconsortium.org Video short - https://www.youtube.com/watch?v=uWDtWNgpK7A To learn more about Oncotarget, please visit https://www.oncotarget.com. MEDIA@IMPACTJOURNALS.COM

Stuff You Missed in History Class
Rosina Bulwer-Lytton's Blighted Life (Part 1)

Stuff You Missed in History Class

Play Episode Listen Later Jun 23, 2025 36:39 Transcription Available


After a difficult childhood, Rosina Bulwer-Lytton landed in a marriage that quickly turned chaotic and stressful, and then became abusive. Part one covers the period of her life up to their separation. Research: “A Scene at the Hertfordshire Election.” The Tiverton Gazette. 6/29/1858. https://www.newspapers.com/image/803824054/ Blain, Virginia. “Rosina Bulwer Lytton and the Rage of the Unheard.” Huntington Library Quarterly , Summer, 1990, Vol. 53, No. 3. Via JSTOR. https://www.jstor.org/stable/3817439 Brown, Andrew. "Lytton, Edward George Earle Lytton Bulwer [formerly Edward George Earle Lytton Bulwer], first Baron Lytton (1803–1873), writer and politician." Oxford Dictionary of National Biography. September 23, 2004. Oxford University Press. Date of access 4 Jun. 2025, https://www-oxforddnb-com.proxy.bostonathenaeum.org/view/10.1093/ref:odnb/9780198614128.001.0001/odnb-9780198614128-e-17314 Bulwer-Lytton, Rosina. “Lady Bulwer Lytton's Appeal to the Justice and Charity of the English Public.” By and For the Author. 1857. Devey, Louisa, editor. “Letters of the late Edward Bulwer, lord Lytton, to his wife.” New York : G. W. Dillingham. 1889. Devey, Louisa. “Life of Rosina, Lady Lytton: With Numerous Extracts from Her Ms. Autobiography and Other Original Documents.” London, Swan Sonnschein, Lowery & Co. 1887. Flynn, Michael J. “Dickens, Rosina Bulwer Lytton, and the ‘Guilt’ of Literature and Art.” Dickens Quarterly, March 2012, Vol. 29, No. 1 (March 2012). Via JSTOR. https://www.jstor.org/stable/45292582 King, Cornelia. “Getting Even: The Mighty Pen of Lady Bulwer Lytton.” The Library Company of Philadelphia. 5/10/2022. https://librarycompany.org/2022/05/10/getting-even/ Latané, D.E. “Edward Bulwer Lytton’s committal of his wife Rosina to a private mental asylum in 1858.” Victorian Web. https://victorianweb.org/authors/bulwer/latane.html McFadden, Margaret. “Anna Doyle Wheeler (1785-1848): Philosopher, Socialist, Feminist.” Hypatia, vol. 4, no. 1, 1989, pp. 91–101. JSTOR, http://www.jstor.org/stable/3809936. Accessed 3 June 2025. Mulvey-Roberts, Marie. "Fame, notoriety and madness: Edward Bulwer-Lytton paying the price of greatness." Critical Survey, vol. 13, no. 2, May 2001, pp. 115+. Gale Literature Resource Center, link.gale.com/apps/doc/A80191856/LitRC?u=mlin_n_melpub&sid=bookmark-LitRC&xid=2669a158. Accessed 27 May 2025. Mulvey-Roberts, Marie. "Lytton, Rosina Anne Doyle Bulwer [née Rosina Anne Doyle Wheeler], Lady Lytton (1802–1882), novelist." Oxford Dictionary of National Biography. October 08, 2009. Oxford University Press. Date of access 28 May. 2025, https://www-oxforddnb-com.proxy.bostonathenaeum.org/view/10.1093/ref:odnb/9780198614128.001.0001/odnb-9780198614128-e-17316 Mulvey-Roberts, Marie. “‘The Very Worst Woman I Ever Heard of’: Rosina Bulwer Lytton and Biography as Vindication.” Women's Writing, 25:2, 253-267, DOI: 10.1080/09699082.2017.1387338 See omnystudio.com/listener for privacy information.

X22 Report
[DS]/China Fighting Back,Trump Drops The Hammer,Peace Through Strength,World Is Watching – Ep. 3670

X22 Report

Play Episode Listen Later Jun 23, 2025 96:44


Watch The X22 Report On Video No videos found (function(w,d,s,i){w.ldAdInit=w.ldAdInit||[];w.ldAdInit.push({slot:17532056201798502,size:[0, 0],id:"ld-9437-3289"});if(!d.getElementById(i)){var j=d.createElement(s),p=d.getElementsByTagName(s)[0];j.async=true;j.src="https://cdn2.decide.dev/_js/ajs.js";j.id=i;p.parentNode.insertBefore(j,p);}})(window,document,"script","ld-ajs");pt> Trump wants the green tax credits removed, energy should not be subsidized by the government. This was only in place for [DS]/[CB] agenda. The [CB] is trying to push the oil prices up by shutting the Straight of Hormuz, this will fail because the oil field in Alaska are opening up. Trump puts the spotlight on the Federal Reserve and calls them out. The [DS]/China are trying to fight back, this will not work, Trump has removed the ability for foreign [DS] nations to receive intelligence, Trump can hit them at anytime. Trump is now sending a message to the [DS] to surrender and he wants the people of Iran to rise up and take back their country. Peace through strength. The world is watching.   Economy   SUBSIDY!). Also, it is almost exclusively made in China!!! It is time to break away, finally, from this craziness!!! (function(w,d,s,i){w.ldAdInit=w.ldAdInit||[];w.ldAdInit.push({slot:18510697282300316,size:[0, 0],id:"ld-8599-9832"});if(!d.getElementById(i)){var j=d.createElement(s),p=d.getElementsByTagName(s)[0];j.async=true;j.src="https://cdn2.decide.dev/_js/ajs.js";j.id=i;p.parentNode.insertBefore(j,p);}})(window,document,"script","ld-ajs"); Interior Dept. Proposes Opening Up 82 Percent Of Alaskan Petroleum Reserve The Department of Interior (DOI) released a draft analysis that proposes reopening up to 82 percent of the 23-million-acre National Petroleum Reserve in Alaska (NPR-A) to oil and gas leasing and development, the agency said in a June 17 statement.   NPR-A was set aside as an emergency oil supply for the U.S. Navy by President Warren Harding in 1923. In 1976, the reserve was transferred to the DOI's Bureau of Land Management (BLM). In 2022, the Biden administration announced the closure of almost half of the NPR-A reserve to oil and gas drilling, overturning a policy from the first Trump administration that sought to boost oil development in the region. The latest proposal reverses the Biden-era restrictions, “consistent with the Trump administration's commitment to Energy Dominance and regulatory reform,” the DOI said. The proposal supports a presidential action, “Unleashing Alaska's Extraordinary Resource Potential,” signed by President Donald Trump on Jan. 20, 2025. The action highlighted that Alaska has an “abundant and largely untapped supply of natural resources” that could deliver energy price relief for Americans, ease trade imbalances, and create high-quality jobs. “Under President Trump's leadership, we're cutting red tape and restoring commonsense policies that ensure responsible development and good stewardship of our public lands,” he said. The Biden-era rule had closed roughly 11 million acres of NPR-A to oil and gas extraction and restricted construction on another 2 million acres. Source: zerohedge.com https://twitter.com/wideawake_media/status/1936695964791640244   something that is good for the elite, or is good for the young, or is good for some versus others." "If it is well done, and if it is well implemented, it would be of service to all citizens." CBDCs not only enable authorities to track who spends what, where, and when—they are programmable, allowing money to be restricted for specific uses, the imposition of expiry dates, and the ability to freeze or limit spending based on user behaviour or location. Once integrated with digital ID, facial recognition, social credit scores and carbon allowances, CBDCs facilitate totalitarian control on an unprecedented scale. The European Central Bank (ECB) is targeting October 2025 t...

Strength In Knowledge
Jump Tests & Elbow Injuries: Unexpected Insights from the Mound

Strength In Knowledge

Play Episode Listen Later Jun 23, 2025 14:50


In this episode of Strength In Knowledge, we step off the mound and into the lab to explore a surprising connection: how lower body jump performance might predict elbow injuries in professional baseball pitchers. Based on the intriguing study by Mayberry, Mullen, and Murayama, we break down how biomechanics and asymmetries seen in jump tests could flag potential risks for UCL injuries.From kinetic chain theory to practical screening tools, we discuss the implications of this research for strength coaches, rehab specialists, and anyone involved in the performance care of throwing athletes. Could a vertical jump really tell you something about elbow health? Turns out—it might.⚾

The Hotshot Wake Up
What's Inside The Proposal To Sell 1.5% Of Public Lands? I Cover This Plan To "Dispose Of" Millions Of Acres. Alaska wildfires pop off, Dozer operator burned in New Mexico.

The Hotshot Wake Up

Play Episode Listen Later Jun 21, 2025 45:01


Frankly Speaking About Family Medicine
A Success Story: The HPV Vaccine - Frankly Speaking Ep 437

Frankly Speaking About Family Medicine

Play Episode Listen Later Jun 16, 2025 13:34


Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-437 Overview: This episode reviews the remarkable impact of the human papillomavirus (HPV) vaccine from 2008–2022, including significant declines in cervical precancer rates. Tune in for key data insights and updated HPV vaccination guidelines to help you close care gaps and strengthen cancer prevention efforts in your practice. Episode resource links: Gargano JW, Stefanos R, Dahl RM, et al. Trends in Cervical Precancers Identified Through Population-Based Surveillance — Human Papillomavirus Vaccine Impact Monitoring Project, Five Sites, United States, 2008–2022. MMWR Morb Mortal Wkly Rep 2025;74:96–101. DOI: http://dx.doi.org/10.15585/mmwr.mm7406a4 • HPV Vaccination Recommendations: Dosing and Schedule • Talking to parents about HPV vaccine Guest: Jill M. Terrien PhD, ANP-BC    Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com