Podcasts about DOI

Detta är ett avsnitt från september 2025.8 februari 2003. Vid Kennedy Space Center i Florida är det fullt av folk. Rymdfärjan Columbia ska återvända till jorden efter 16 dagar i rymden, och familjer och personal har samlats för att välkomna astronauterna tillbaka. Men färjan dyker aldrig upp. Och snart kommer rapporter om märkliga ljusfenomen över Arizona och New Mexico. Ljusfenomen som en gång var en rymdfarkost.Detta är berättelsen om Columbia-katastrofen. Ett rutinmässigt uppdrag, som slutade i tragedi.Inläsare: Tind SonebyManus och research: Emmeli NyblomRedaktör: Alex HaegerProducent: Oliver BergmanKällor:Astronauts Memorial Foundation. Evelyn Husband Thompson. (2024-01-29). https://www.amfcse.org/board-of-directors/evelyn-husband-thompson (Hämtad 2025-06-25). ABC News. Profile of Columbia Commander Rick Husband. (2003-02-01). https://abcnews.go.com/US/story?id=90109&page=1 (Hämtad 2025-06-25). ABC News (b). Feb. 1, 2003: Space shuttle Columbia disaster [Filmklipp]. YouTube. (Publicerad 2003-02-01, publicerad på Youtube 2024-02-01). https://www.youtube.com/watch?v=-euNiLdcu_I (Hämtad 2025-06-25). CNN. In pictures: Space Shuttle Columbia's final flight. (Uppdaterad 2024-04-12). https://edition.cnn.com/2024/04/05/us/gallery/space-shuttle-columbia-final-flight (Hämtad 2025-06-25). CNN (Editorial Research). Space Shuttle Columbia Fast Facts. (Uppdaterad 2023-01-17). https://edition.cnn.com/2013/09/30/us/space-shuttle-columbia-fast-facts (Hämtad 2025-06-25). Denver Post (The Associated press). 10 years after Columbia disaster, family members remember. (Uppdaterad 2016-04-30). https://www.denverpost.com/2013/01/30/10-years-after-columbia-disaster-family-members-remember/ (Hämtad 2025-06-25). Dobrijevic, D. & Howell, E. Space Shuttle Columbia.Space.com. (2021-10-26). https://www.space.com/18008-space-shuttle-columbia.html (Hämtad 2025-06-25). Encyclopaedia Britannica (b). Space shuttle. (2025-05-16). https://www.britannica.com/technology/space-shuttle (Hämtad 2025-06-25). Encyclopaedia Britannica (a). Challenger disaster. (u.å.). https://www.britannica.com/event/Challenger-disaster (Hämtad 2025-06-25). European Space Agency. Space Shuttle Columbia – Information Note No. 1. (2003-02-02). https://www.esa.int/Science_Exploration/Human_and_Robotic_Exploration/Space_Shuttle_Columbia_-_Information_Note_No._1 (Hämtad 2025-06-25). Hall, J. L. Columbia and Challenger: organizational failure at NASA. (2003). Astronomy Department/School of Information Management and Systems, Astronomy Department, University of California at Berkeley. Elsevier Ltd. DOI: 10.1016/j.spacepol.2003.08.013 https://josephhall.org/papers/nasa.pdf?utm_source=chatgpt.com Kershaw, S. Families lost more than heroes in shuttle tragedy. The New York Times. (2003-02-16). https://www.nytimes.com/2003/02/16/us/loss-shuttle-mood-shuttle-disaster-families-lost-more-than-mere-heroes.html (/ här kan man också nå den: https://eu.gainesville.com/story/news/2003/02/16/families-lost-more-than-heroes-in-shuttle-tragedy/31628368007/) (Hämtad 2025-06-25). Kjerside Poulsen, M. NASA – Bakgrunden till NASA. Illustrerad Vetenskap. (2015-01-12). https://illvet.se/universum/rymdresor/nasa-bakgrunden-till-nasa (Hämtad 2025-06-25). Kridler, C. & Halvorson, T. Picking Up the Pieces: Solving the Columbia Mystery. Space.com. (2005-07-04). https://www.space.com/1282-picking-pieces-solving-columbia-mystery.html (Hämtad 2025-06-26). Mangan, L. The Space Shuttle That Fell to Earth review – the finest possible tribute to the astronauts who lost their lives. The Guardian. (2024-02-12). https://www.theguardian.com/tv-and-radio/2024/feb/12/the-space-shuttle-that-fell-to-earth-review-a-moving-tribute-to-the-astronauts-who-lost-their-lives-in-the-columbia-disaster (Hämtad 2025-06-25). NASA (a). 40 Years Ago: The Launch of STS-1 Just Two Weeks Away. (u.å.) https://www.nasa.gov/history/40-years-ago-the-launch-of-sts-1-just-two-weeks-away/ (Hämtad: 2025-06-25). NASA (b). Columbia Accident Investigation Board Report Volume I. The Government Printing Office, Washington DC. (2003). https://ntrs.nasa.gov/api/citations/20030066167/downloads/20030066167.pdf (Hämtad 2025-06-25). NASA (c). (Uri, J). 20 Years Ago: Remembering Columbia and Her Crew, 2023-01-26, https://www.nasa.gov/history/20-years-ago-remembering-columbia-and-her-crew/?utm_source=chatgpt.com (hämtad 2025-06-25). P3 Dokumentär. Rymdfärjan Columbia och dödskraschen [Podcast]. Sveriges Radio. (2024-08-22). https://www.sverigesradio.se/avsnitt/ny-p3-dokumentar-rymdfarjan-columbia-och-dodskraschen (Hämtad 2025-06-25). Rice University. John F. Kennedy Moon Speech – Rice Stadium. Rice University. (u.å.). https://www.rice.edu/jfk-speech (Hämtad 2025-06-25). Riley, P. Timeline of the Space Race 1957-69. Encyclopedia Brittanica. (Uppdaterad 2025-06-13). https://www.britannica.com/story/timeline-of-the-space-race (Hämtad 2025-06-25). Royal Museums Greenwich. Why did we stop going to the Moon? (u.å.). https://www.rmg.co.uk/stories/space-astronomy/why-did-we-stop-going-moon (Hämtad 2025-06-25). Strickland, A. More than 20 years later, families of the Columbia crew carry on their loved ones' legacies. CNN. (Uppdaterad 2024-04-12). https://edition.cnn.com/2024/04/12/world/nasa-columbia-shuttle-crew-families-scn (Hämtad 2025-06-25). The Guardian. ‘Lock the doors' – words that marked loss of hope for shuttle. (2003-02-13). https://www.theguardian.com/world/2003/feb/13/columbia.spaceexploration (Hämtad 2025-06-25). Tilley, J. Rick Husband: Life and Legacy of the STS-107 Columbia Commander, uppdaterad 2020-01-16, Texas State Historical Association, https://www.tshaonline.org/handbook/entries/husband-rick-douglas (hämtad 2025-06-25). Tillman, N.T. The First Space Shuttle Flight Into Space. Space.com. (2019-05-07). https://www.space.com/16793-first-space-shuttle-launch.html (Hämtad 2025-06-25). TT. 30 år sedan rymdfärjan Challenger exploderade. Epoch Times. (2016-01-27). https://www.epochtimes.se/30-ar-sedan-rymdfarjan-challenger-exploderade (Hämtad 2025-06-25). TV4 Nyhetsmorgon. Stefan Borg blev ögonvittne till katastrofen när Challengers sprängdes [TV-program]. (2016-01-28). https://www.youtube.com/watch?v=UkmgTR4Jp6s (Hämtad 2025-06-25). Workman, K. The Challenger Space Shuttle Disaster, 30 Years Later. The New York Times. (2016-01-28). https://www.nytimes.com/interactive/2016/01/29/science/space/challenger-explosion-30-year-anniversary.html (hämtad 2025-06-25).

In this episode of the EADV Podcast, Prof. Michela Starace, Chair of the EADV Hair Diseases Task Force, is joined by Task Force Co-Chairs Prof. Alexander Katoulis and Dr. Matilde Iorizzo to discuss current perspectives on scarring alopecias and the challenges of diagnosis and management. The conversation explores the relationship between lichen planopilaris and frontal fibrosing alopecia, highlighting ongoing debates around their classification, clinical presentation, and treatment approaches. The speakers also discuss the value of trichoscopy in everyday practice, the importance of early recognition of inflammatory activity, and the role of consensus-driven guidance in supporting clinicians faced with complex cases. Looking ahead, the experts examine emerging therapeutic strategies, including the potential role of JAK inhibitors, while reflecting on the need for further evidence and long-term data. The episode highlights the importance of recognising the emotional and psychosocial impact of hair disorders, while encouraging clinicians to adopt a patient-centred approach to care. Through practical insights, shared experiences, and discussion of emerging developments, the speakers underline the value of education, collaboration, and empathy in improving outcomes for people living with alopecia and other hair diseases. References: Seyed Jafari SM, Starace M, Katoulis A, et al. Management of classic lichen planopilaris: The EADV Task Force on Hair Diseases position statement. Journal of the European Academy of Dermatology and Venereology (JEADV). Published online 18 March 2026. DOI: 10.1111/jdv.70379. Waśkiel-Burnat A, Starace M, Iorizzo M, Katoulis A, et al. Management of folliculitis decalvans: The EADV Task Force on Hair Diseases position statement. Journal of the European Academy of Dermatology and Venereology (JEADV). 2025;39(8):1385–1394. DOI: 10.1111/jdv.20687 Starace MVR, Pampaloni F, Iorizzo M, Katoulis A, et al. Delphi Consensus on the Distinct Clinical and Histopathological Features of Lichen Planopilaris and Frontal Fibrosing Alopecia: Insights From the Hair Diseases EADV Task Force. International Journal of Dermatology. 2025;64(7):1246–1254. DOI: 10.1111/ijd.17780.

Du wachst auf, bist hellwach – und kannst dich nicht rühren. Etwas drückt auf deine Brust, im Zimmer steht eine dunkle Gestalt, du willst schreien und bringst keinen Ton heraus. Was passiert da gerade? In dieser Folge sprechen Franca und Christian über die Schlafparalyse – eine Grenzerfahrungen des Schlafs, die mehr Menschen erleben als man glaubt. Sie entsteht, wenn das Bewusstsein schon wach ist, während der Körper noch in der Muskellähmung des Traumschlafs feststeckt. Für die allermeisten Menschen ist sie völlig harmlos – und je besser man weiß, was da passiert, desto weniger Macht hat sie über einen. Francas neues Buch: Die innere Oma — ab 4. September 2026, jetzt kurze Zeit mit handschriftlicher Signatur vorbestellbar: https://shop.autorenwelt.de/products/die-innere-oma-von-franca-cerutti Alle Tourdaten und Tickets für Dezember: https://www.190a.de/psychologie-to-go/ Unterstütze uns auf Steady: https://steady.page/de/psychologie-to-go/about Hinterlasse eine Frage oder einen Kommentar auf unserem Anrufbeantworter: https://www.speakpipe.com/Psychologietogo Quellen: Sharpless, B. A. (2016): A clinician's guide to recurrent isolated sleep paralysis. Neuropsychiatric Disease and Treatment. DOI: https://doi.org/10.2147/NDT.S100307 Hefnawy, M. T. et al. (2024): Prevalence and Clinical Characteristics of Sleeping Paralysis. Cureus (Open Access). DOI: https://doi.org/10.7759/cureus.53212 Jalal, B. (2018): The neuropharmacology of sleep paralysis hallucinations. Psychopharmacology. DOI: https://doi.org/10.1007/s00213-018-5042-1 Denis, D., French, C. C., Gregory, A. M. (2018): A systematic review of variables associated with sleep paralysis. Sleep Medicine Reviews. DOI: https://doi.org/10.1016/j.smrv.2017.05.005 Du möchtest mehr über unsere Werbepartner erfahren? Hier findest du alle Infos & Rabatte: https://linktr.ee/psychologietogo Du möchtest Werbung in diesem Podcast schalten? Dann erfahre hier mehr über die Werbemöglichkeiten bei Seven.One Audio: https://www.seven.one/portfolio/sevenone-audio

In dieser abschließenden Sitzung der Vorlesung „Grammatik in der Schule“ fasse ich die über das Semester entwickelten Kernbereiche noch einmal zusammen. Der Fokus lag, ausgehend vom homo narrans, auf der Verknüpfung von Grammatikvermittlung mit Erzählungen, wobei traditionelle Ansätze kritisch beleuchtet und moderne gebrauchsbasierte sowie konstruktionsdidaktische Alternativen diskutiert werden. Auf der Basis der Analyse von umgangssprachlichen Phänomenen, Modalkonstruktionen (als Konstruktionen der Faktizitätsmarkierung), Geltungsmodifikatoren (Temporal- und Lokaladverbialia) und der Verknüpfung mentaler Räume wird ein alternativer Weg für den Unterricht aufgezeigt: die Umkehrung der Vermittlungshierarchie mit einer Oerientierung auf quantitativ häufige sprachliche Strukturen. Zum Abschluss werden alle relevanten organisatorischen Informationen zum Ablauf, den zugelassenen Hilfsmitteln und der Abgabe der anstehenden digitalen Klausur erläutert.Präsentation (*.pdf): Alexander Lasch. 2026. Grammatik in der Schule. Zenodo. DOI: ⁠⁠⁠⁠⁠⁠⁠https://doi.org/10.5281/zenodo.19236685⁠⁠⁠⁠⁠⁠⁠. Videoaufzeichnungen: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://youtube.com/@AlexanderLasch⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Informationen & Material zu allen Vorlesungen: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.gls-dresden.de/tag/podcast_vorlesung/⁠⁠⁠⁠⁠⁠⁠⁠⁠. Worksheet zu den Vorlesungen: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://docs.google.com/document/d/1NH1z5FwzCmA6UOAjwRrhZEDe5fo3Lmq5-3xDLlM2B7Y/edit?tab=t.99a8y21twmjz⁠⁠⁠. Intro: "Reflections" von Scott Holmes (CC BY via ⁠⁠⁠⁠⁠⁠FMA⁠⁠⁠⁠⁠⁠).#Linguistik #OER #Sprache #Sprachwissenschaft #Grammatik #Konstruktionsgrammatik #Konstruktionsdikdatik

How should prostate biopsy be performed in the MRI era, and what impact does biopsy strategy have on treatment planning?In this episode, Prof. Francesco Sanguedolce is joined by Prof. Francesco Giganti, Prof. Gianluca Giannarini and Prof. Lars Budäus to discuss the latest expert recommendations on prostate biopsy.The conversation explores the importance of high-quality MRI, targeted and perilesional biopsy strategies, the role of emerging imaging technologies and the ongoing debate surrounding systematic biopsy.The faculty also discuss how biopsy findings can influence decisions on focal therapy, nerve-sparing surgery and lymph node dissection, while highlighting current areas of consensus and the questions that still remain in clinical practice.ProBIOPSY: A Multidisciplinary International Consensus on Standards for Prostate Biopsy, European Urology, article in press. Doi.org/10.1016/j.eururo.2026.06.012)This podcast is brought to you in collaboration with the EAU Section of Urological Imaging.For more EAU podcasts, please go to your favourite podcast app and subscribe to our podcast channel for regular updates: Apple Podcasts, Spotify, EAU YouTube channel.

Anna and Avery kick off with a decade-long game of cosmic hide-and-seek that has finally ended: Beta Pictoris d, the faintest exoplanet ever directly imaged from Earth, found lurking in more than ten years of archival images — and orbiting a star in the southern constellation Pictor. Then it's the completion of VLASS, the sharpest radio map of the whole sky ever made, arriving just as the Rubin Observatory's optical survey switches on. The James Webb Space Telescope has caught a supermassive black hole feeding itself in the Centaurus Cluster — the missing link in a decades-old mystery. A Pluto system double bill follows: the first landslides ever identified on Pluto, and evidence written in Charon's mountains that the big moon once spun more than ten times faster than it does today — both delivered by New Horizons data from 2015. Finally, SpaceX's latest FCC filing reveals Starlink satellites made over 355,000 collision-avoidance manoeuvres in the past year — nearly one dodge per satellite per week — and experts are warning about where the trend leads. Plus dark-sky Southern Hemisphere stargazing and a Starship Flight 13 launch reminder. Chapters •       00:00 — Intro & billboard •       01:30 — Beta Pictoris d: the faintest exoplanet ever imaged from Earth •       05:30 — VLASS complete: the sharpest radio map of the sky •       08:45 — JWST reveals how supermassive black holes feed •       12:15 — Pluto has landslides (Pluto double, part 1) •       15:00 — Charon's slowing spin (Pluto double, part 2) •       17:45 — Starlink's 355,000 collision dodges in a year •       20:45 — Southern Hemisphere skywatch + Starship Flight 13 reminder •       22:30 — Outro Story sources •       Beta Pictoris d: ESO release eso2609 (eso.org) · The Astrophysical Journal Letters · space.com · phys.org •       VLASS completion: NRAO release (public.nrao.edu/news/vlass-observations-complete) · phys.org •       JWST / NGC 4696: Université de Montréal · The Astrophysical Journal Letters · phys.org / EurekAlert •       Pluto landslides: Icarus (Discenza et al. 2026) · phys.org · Discover Magazine · Science News •       Charon despinning: Nature Communications (Chen et al. 2026, DOI 10.1038/s41467-026-75069-7) · phys.org · Gizmodo •       Starlink manoeuvres: SpaceX semiannual FCC constellation status report, via space.com Boilerplate Astronomy Daily is part of the Bitesz.com Podcast Network. Show notes, links and the full back catalogue at astronomydaily.io. Follow @AstroDailyPod on X, Instagram, TikTok and Tumblr. New episodes every day.Become a supporter of this podcast: https://www.spreaker.com/podcast/astronomy-daily-the-latest-space-news--5648921/support.Sponsor Details:Ensure your online privacy by using NordVPN. To get our special listener deal and save a lot of money, visit www.bitesz.com/nordvpn. You'll be glad you did!Become a supporter of Astronomy Daily by joining our Supporters Club. Commercial free episodes daily are only a click way... Click HereThis episode includes AI-generated content.

Each month, we will highlight a paper published in Aging chosen as the “Editors' Choice.” These selections are handpicked by our editors and accompanied by a brief summary, showcasing research with significant impact and novel insights in aging and age-related diseases. Cellular senescence is a hallmark of aging and age-related disease, yet the diverse mechanisms that trigger this cellular state remain incompletely understood. The review recently published in Volume 18 of Aging, titled “The multifaceted inducers of cellular senescence,” examines the many intrinsic and extrinsic stimuli that induce senescence, including DNA damage, oxidative and mitochondrial stress, telomere attrition, oncogene activation, cell–cell fusion, and developmental signals. The authors, Hilah Gal and Valery Krizhanovsky, explain how these distinct pathways converge on a stable cell-cycle arrest. By highlighting the complexity and heterogeneity of senescent cells, the authors provide valuable insights that may guide the development of future therapies targeting senescence to promote healthy aging and combat age-related diseases. DOI - https://doi.org/10.18632/aging.206391 Corresponding author - Valery Krizhanovsky - valery.krizhanovsky@weizmann.ac.il Abstract video - https://www.youtube.com/watch?v=5Y7R_8GQ1gk Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206391 Keywords - aging, cell senescence To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Wir springen in dieser Folge in die USA, genauer nach San José in Kalifornien. Dort steht ein auf den ersten Blick rätselhaftes Gebäude, bekannt als das Winchester Mystery House. Es ist heute eine viel besuchte Attraktion, der eine geisterhafte Legende zugrunde liegt. Wir sprechen in dieser Folge über diese Legende: wie dieses Haus zustande kam, wer die angeblich so geheimnisvolle Bauherrin war und warum gerade das Ende des 19. Jahrhunderts in den USA ein so fruchtbarer Boden für Geistergeschichten ist. // Erwähnte Folgen - GAG237: Friedrich Anton Mesmer und der Animalische Magnetismus – https://gadg.fm/237 - GAG505: William H. Mumler, Geisterfotograf – https://gadg.fm/505 - GAG546: Sarah Biffin, Miniaturmalerin – https://gadg.fm/546 // Literatur - Haag, Pamela, The Gunning of America: Business and the Making of American Gun Culture, New York: Basic Books, 2016. - Ignoffo, Mary Jo, Captive of the Labyrinth: Sarah L. Winchester, Heiress to the Rifle Fortune, Columbia: University of Missouri Press, 2010. - Junker, Christine R., „Unruly Women and Their Crazy Houses: Sarah Winchester's Unconventional Domesticity“, in: Home Cultures 12/3 (2015), S. 329–346, DOI: 10.1080/17406315.2015.1084763. - Lueck, Amy J., „Haunting Women's Public Memory: Ethos, Space, and Gender in the Winchester Mystery House“, in: Rhetoric Review 40/2 (2021), S. 107–122, DOI: 10.1080/07350198.2021.1883832. Das eingangs erwähnte Past Puzzle findet sich hier: https://www.pastpuzzle.de Hier gibt's die von Lene erwähnte "Lore"-Folge: https://www.lorepodcast.com/episodes/79 //Aus unserer Werbung Du möchtest mehr über unsere Werbepartner erfahren? Hier findest du alle Infos & Rabatte: https://linktr.ee/GeschichtenausderGeschichte //Geschichten aus der Geschichte jetzt auch als Brettspiel! Werkelt mit uns am Flickerlteppich! Gibt es dort, wo es auch Becher, T-Shirts oder Hoodies zu kaufen gibt: https://geschichte.shop // Wir sind jetzt auch bei CampfireFM! Wer direkt in Folgen kommentieren will, Zusatzmaterial und Blicke hinter die Kulissen sehen will: einfach die App installieren und unserer Community beitreten: https://www.joincampfire.fm/podcasts/22 //Wir haben auch ein Buch geschrieben: Wer es erwerben will, es ist überall im Handel, aber auch direkt über den Verlag zu erwerben: https://www.piper.de/buecher/geschichten-aus-der-geschichte-isbn-978-3-492-06363-0 Wer unsere Folgen lieber ohne Werbung anhören will, kann das über eine kleine Unterstützung auf Steady oder ein Abo des GeschichteFM-Plus Kanals auf Apple Podcasts tun. Wir freuen uns, wenn ihr den Podcast bei Apple Podcasts oder wo auch immer dies möglich ist rezensiert oder bewertet. Wir freuen uns auch immer, wenn ihr euren Freundinnen und Freunden, Kolleginnen und Kollegen oder sogar Nachbarinnen und Nachbarn von uns erzählt! Du möchtest Werbung in diesem Podcast schalten? Dann erfahre hier mehr über die Werbemöglichkeiten bei Seven.One Audio: https://www.seven.one/portfolio/sevenone-audio

When colleges and universities think about student well-being, the conversation often begins and ends with counseling centers. But what if student well-being is much broader than mental health services alone? In this episode of On Campus, Dr. Maithreyi Gopalan, Associate Professor at the University of Oregon, for a discussion about how institutions can build a campus-wide approach to student well-being by focusing on belonging, connection, and student flourishing. Based on her research, Dr. Gopalan explains why a student's sense of belonging is strongly connected to persistence, graduation, academic success, and mental health outcomes. The conversation explores practical strategies for higher education leaders, including measuring belonging as an institutional outcome, conducting regular student pulse checks, strengthening advising and first-year experiences, and creating meaningful connections throughout the student journey. Dr. Gopalan also discusses the role faculty play as "first responders" in supporting students, the importance of equity-centered well-being initiatives, and why institutions must move beyond reactive approaches to create environments where all students can thrive. Whether you're a student affairs professional, faculty member, administrator, or higher education leader, this episode offers research-based insights for building a more supportive and successful campus community.  Resources Gopalan, M., & Brady, S. T. (2020). College Students' Sense of Belonging: A National Perspective. Educational Researcher, 49(2), 134 137. https://protect.checkpoint.com/v2/r01/___https://doi.org/10.3102/0013189X19897622___.YzJ1OmNpdGlwcm9ncmFtMTpjOm86NjgwOGY4OTBmZjYyNzJkNjA4YjdkM2YwMDYwMTgyODY6NzowMzMxOjYxYmQ2ZGQxMTU1N2ExYzI5YmVmYTQ0MmYyNGMxNmE4M2YzMmMzZjUwMmU4YWZjOWRiNWFjYWJjMmU5MDQ3NjQ6dDpUOkY Gopalan, M., Linden-Carmichael, A. Lanza, S. (2022). College Students' Sense of Belonging and Mental Health Amidst the COVID-19 Pandemic, Journal of Adolescent Health, 70(2), 228-233. https://protect.checkpoint.com/v2/r01/___https://doi.org/10.1016/j.jadohealth.2021.10.010___.YzJ1OmNpdGlwcm9ncmFtMTpjOm86NjgwOGY4OTBmZjYyNzJkNjA4YjdkM2YwMDYwMTgyODY6NzpjOTJiOjRmN2IxNTc1Mjc3MWIxYmYxZjA5MDIzNDIyZDcwN2FiY2E2ZmExYzgwZmMxNjdhZGQ2MmE1ZTFlMWZlYWY1OWY6dDpUOkY Murphy, M.C., Gopalan, M., Carter, E. R., Emerson, K. T. U., Bottoms, B. L., and Walton, G.M., (2020). A customized belonging intervention improves retention of socially disadvantaged students at a broad-access university Science Advances, 6(29). DOI: 10.1126/sciadv.aba4677 Walton, & Cohen. (2007). A question of belonging: Race, social fit, and achievement. Journal of Personality and Social Psychology, 92(1), 82. https://protect.checkpoint.com/v2/r01/___https://doi.org/10.1037/0022-3514.92.1.82___.YzJ1OmNpdGlwcm9ncmFtMTpjOm86NjgwOGY4OTBmZjYyNzJkNjA4YjdkM2YwMDYwMTgyODY6NzpiZmI3OmM5YmYwYTY2YmE3ZGQxMzY0MzM1ZTg2OWIwYjBkNTZmYzNmMGEyNzhkMmQ5ZThiZGEzZTc2M2ZiZTY0NDkzMjA6dDpUOkY 

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. Although many GISTs can be effectively treated with targeted therapies, their response to treatment depends largely on the specific genetic alterations driving tumor growth. Advances in molecular testing have transformed the management of these tumors, allowing clinicians to tailor treatment based on each patient's genetic profile. A case report published in Volume 17 of Oncotarget, titled “Small bowel GIST harboring concurrent KIT exon 9 duplication and SDHC mutation: A case report,” describes an exceptionally rare case involving a patient whose tumor carried two genetic alterations that are traditionally considered mutually exclusive. Full blog post - https://www.oncotarget.org/2026/07/13/rare-genetic-combination-in-gastrointestinal-tumor-offers-new-insights-into-precision-cancer-care/ DOI - https://doi.org/10.18632/oncotarget.28863 Correspondence to - Joseph G. Crompton - jcrompton@mednet.ucla.edu Abstract video - https://www.youtube.com/watch?v=eB_QG2vBNCE Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28863 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, GIST, KIT duplication, SDHC mutation, genetic testing, case report To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY — July 13, 2026 — A new #review was #published in Volume 18 of Aging on June 26, 2026, titled “Hormonal dimorphism in sarcopenia disease.” The review was led by first author Romain Menard and corresponding author Romain Madelaine from the MDI Biological Laboratory, Kathryn W. Davis Center for Regenerative Biology and Aging, Bar Harbor, Maine, USA. Sarcopenia—the progressive loss of skeletal muscle mass, strength, and physical function with aging—is one of the leading causes of frailty and disability in older adults. Although the condition affects millions of people worldwide and has been recognized as a disease by the World Health Organization since 2016, treatment options remain largely limited to exercise and nutritional interventions, with no approved medications specifically targeting the disease. Growing evidence now suggests that one reason for this limited success is that sarcopenia develops through distinct biological mechanisms in women and men. In this comprehensive review, the authors examine how biological sex influences the hormonal mechanisms underlying muscle aging. They focus on three peptide hormones—apelin, insulin, and oxytocin—and describe how age-related changes in these interconnected signaling networks contribute to muscle decline through distinct biological pathways in women and men. According to the review, women often experience an abrupt decline in muscle health during menopause as estrogen levels fall rapidly. This hormonal transition disrupts apelin signaling, accelerates insulin resistance, reduces oxytocin-mediated muscle regeneration, and impairs the function of satellite cells, the muscle stem cells responsible for repair and regeneration. In contrast, men generally undergo a slower, more gradual decline in muscle function that parallels progressive reductions in testosterone, resulting in different patterns of hormonal dysregulation and disease progression. The review also highlights the central roles of apelin, insulin, and oxytocin in maintaining healthy skeletal muscle. Together, these hormones regulate muscle metabolism, glucose utilization, mitochondrial function, protein homeostasis, inflammation, and satellite-cell activity through overlapping signaling pathways. Disruption of this hormonal network during aging is proposed to contribute to impaired muscle repair, reduced metabolic function, chronic inflammation, and progressive muscle loss. Full press release - https://aging-us.net/2026/07/13/sex-specific-hormones-could-hold-the-key-to-better-sarcopenia-treatments/ DOI - https://doi.org/10.18632/aging.206392 Corresponding author - Romain Madelaine - rmadelaine@mdibl.org Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206392 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, sarcopenia, hormonal dimorphism, muscle aging, sex-stratified medicine, sexual dimorphism To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

A malevolent force is operating through every lever of power — government, media, finance, military — and for the first time in history, its reach is nearly global. Borders that once kept the damage in check are gone. Good has been inverted as evil. Most people feel it but can't name it.In this episode of Presbyter Chat, Darren Kelama names it — and traces it straight back to the Pre-Nicene Christians who fought the same enemy centuries ago. Drawing on scripture from the first Christian Bible of 144 AD, academic research from the Journal of Pre-Nicene Christian Studies, and the survival playbook of the most persecuted denomination in history — the Marcionites — this episode lays out:• Who the "sons of disobedience" are and how they operate through hijacked institutions • Why voting, politics, and the democratic path are now closed • The ancient Greek discipline of Apatheia — calm, detached clarity in the face of manufactured chaos • How persecuted Christians survived by becoming invisible to a system that feeds on fear • Practical steps to disconnect, go off-grid, and protect your family before the window closesScripture readings from the Evangelion and the Epistle to the Laodiceans. Referenced theologians include Thomas Römer, Walter Brueggemann, Peter Enns, and A.W. Mitchell's Theophanic Replacement Protocol.The enemy cannot crush an opponent it cannot see, cannot starve, and cannot terrorize. Your duty is to survive.Notes:Mitchell, A. W. "The Theophanic Replacement Protocol: A Forensic Reconstruction of Divine Identity Theft, Textual Erasure, and the Formation of Nicene Christianity." Journal of Pre-Nicene Christian Studies (2025). DOI: 10.5281/zenodo.17964659.Romer, Thomas. The Invention of God. Cambridge, MA: Harvard University Press, 2015Sorabji, Richard. Emotion and Peace of Mind: From Stoic Agitation to Christian Temptation. Oxford: Oxford University Press, 2002.The Very First Bible: The Evangelion and Apostolikon (144 AD). 2020. Marcionite Church (marcionitechurch.org). ISBN: 978-0578641591. LinkMarcionite Church (MarcioniteChurch.org)Podcast based largely on this paper: https://www.journal.pre-nicene.org/JPCS-July-2026.htmlExternal media: https://www.youtube.com/@PreNiceneTVFree PreNicene Bible ebook version: https://www.theveryfirstbible.org/ebook.html

All of this week's episodes of It Could Happen Here put together in one large file. Palestine in the World Cup What's Wrong with Human Rights What's Wrong with Human Rights, Pt. 2 A Report from the Great American State Fair Executive Disorder: Platner Allegations, Return of the Tariffs, ICE Shootings You can now listen to all Cool Zone Media shows, 100% ad-free through the Cooler Zone Media subscription, available exclusively on Apple Podcasts. So, open your Apple Podcasts app, search for “Cooler Zone Media” and subscribe today! http://apple.co/coolerzone Sources/Links: Palestine in the World Cup https://jewishcurrents.org/de-normalizing-israeli-normalization-at-the-world-cup https://agsi.org/analysis/palestine-activism-in-the-world-cup/ https://www.aljazeera.com/video/newsfeed/2026/6/12/activists-form-human-palestine-flag-at-world-cup-opener-in-mexico-city https://www.nbcnewyork.com/world-cup/palestinian-head-soccer-says-denied-us-visa-attend-world-cup/6512472/ https://www.middleeasteye.net/trending/bosnia-advances-world-cup-free-palestine-chants-fans-go-viral-once-again https://www.aljazeera.com/features/2026/6/22/football-war-and-solidarity-why-gaza-fans-turned-to-spain-this-world-cup https://www.aljazeera.com/sports/2026/6/12/palestine-football-chief-says-he-wasnt-granted-us-visa-to-attend-world-cup What's Wrong with Human Rights Human Rights as Moral Progress? A Critique by Jarett ZigonCULTURAL ANTHROPOLOGY, Vol. 28, Issue 4, pp. 716–736. ISSN 0886-7356, online ISSN 1548-1360. C 2013 by the American Anthropological Association. All rights reserved. DOI: 10.1111/cuan.12034 Agamben, Arendt and Human Rights: Bearing Witness to the Human. 2012John Lechte & Saul NewmanState of Exception. 2005Giorgio Agamben, translated by Kevin Attell The Need for Roots: Prelude to a Declaration of Duties Towards Mankind Simone Weil. Routledge Classics 2002 Philosophize This! - Episode #191: The Modern Day Concentration Camp and the Failure of Human Rights by Stephen West Executive Disorder: Platner’s Allegations, Return of the Tariffs, ICE Shootings https://www.aljazeera.com/news/liveblog/2026/7/3/iran-war-live-tehran-slams-us-ahead-of-huge-funeral-for-ali-khamenei?update=4731595 https://thehill.com/homenews/senate/5955865-mitch-mcconnell-senate-health-status/ https://www.cnn.com/2026/07/06/us/graham-platner-racicot-allegation-maine-invs https://www.politico.com/news/2026/07/06/graham-platner-sexual-assault-allegation-00987737 https://x.com/akela_lacy/status/2074604814810415293?s=20 https://x.com/grace_panetta/status/2074266651244073227?s=20 https://www.nytimes.com/2026/07/06/us/politics/who-would-replace-graham-platner-maine.html https://x.com/sahilkapur/status/2074678417006420067 https://www.bangordailynews.com/2026/07/08/politics/elections/maine-democrats-want-convention-replace-graham-platner/ https://ustr.gov/about/policy-offices/press-office/press-releases/2026/june/ustr-makes-findings-and-proposes-action-60-section-301-investigations-relating-failures-take-action https://thediplomat.com/2026/06/asean-and-trumps-section-301-tariffs/ https://www.reuters.com/business/latin-american-countries-some-steelmakers-argue-us-tariff-exemptions-2026-07-07/ https://www.congress.gov/crs_external_products/IF/PDF/IF11346/IF11346.31.pdf https://www.yahoo.com/news/politics/articles/democratic-attorneys-general-oppose-latest-172500930.html https://www.msn.com/en-in/news/other/fresh-trump-tariff-threat-looms-what-is-india-s-strong-stand-on-us-section-301-probe-that-proposes-12-5-duties-explained/ar-AA27rLMq https://www.msn.com/en-ca/money/general/canada-says-there-s-no-basis-for-trump-s-forced-labour-tariffs/ar-AA27sMJy https://www.reuters.com/world/french-lawmakers-back-police-shootings-law-dubbed-licence-kill-by-critics-2026-07-08/ https://www.citizen.org/wp-content/uploads/Complaint-in-IALDF-v.-Rubio.pdf https://www.cnn.com/2026/07/07/us/houston-ice-shooting-death https://www.reuters.com/world/americas/fatal-ice-shooting-houston-sparks-demands-transparency-independent-investigation-2026-07-08/ https://www.nytimes.com/2026/07/08/us/houston-ice-shooting.html https://www.wgal.com/article/pa-harrisburg-ice-agent-shoots-video/71807714 https://www.cnn.com/2026/07/04/us/live-news/july-4-trump-speech-america-250?post-id=cmr792ght00053b6r6tl4lvzn https://www.cnn.com/2026/07/04/us/live-news/july-4-trump-speech-america-250?post-id=cmr78t2tf000e3b6rxm0jppbj https://www.npr.org/2026/07/04/g-s1-132025/mount-rushmore-speech-trump-july-4-250See omnystudio.com/listener for privacy information.

In this Supplement Stack Series episode, Nurse Doza breaks down his Good Poops Protocol—a simple liver and gut detox built on three MSW supplements: the Gut glutamine powder, Liver Boost, and Berberine. He explains why gut issues often show up before liver and gallbladder trouble, how repairing the digestive tract may ease inflammation, and how pairing the two-month reset with a Mediterranean diet and better daily habits supports better energy, weight, and, of course, better poops. FEATURED PARTNER The Good Poops Protocol bundles three MSW Nutrition supplements—the Gut glutamine powder, Liver Boost, and Berberine—into one two-month liver and gut detox designed to help reset, repair, and support the digestive tract discussed in this episode. Because gut, liver, and gallbladder issues so often travel together, the protocol targets all three at once, and pairs best with a Mediterranean-style diet and simple daily habits.

Diese Vorlesung beleuchtet das Spannungsfeld zwischen Umgangssprache und Standardsprache. An konkreten Beispielen untersuchen wir, wie grammatische Abweichungen (wie der Zusammenfall von Dativ und Akkusativ) im Schulunterricht konstruktionsdidaktisch und variationslinguistisch aufgearbeitet werden können. Die Vorlesung schlägt dabei eine Brücke zwischen der Analyse von jugendsprachlichen Merkmalen auf der einen und regionalsprachlichen Merkmalen auf der anderen Seite, die sich bis tief in die Geschichte des mitteldeutschen Raumes nachzeichen lassen. Bitte außerdem nicht wundern: Bei "in ganzen Land", einem zunächst nur an der Oberfläche analysierten Beispiele, wird zwar nach Dativ flektiert, durch das Fehlen des Artikels ("dem") bzw. dessen Verschmelzung mit der Präposition ("im") ist der Status dieser Phrase mehr als fraglich und die Nähe zu "in'n Wald" gegeben. Das hätte auch Konsequenzen für den Status des nominalen Flexionsparadigmas. So erklärt sich dann auch "in ihren Schloss": In "ihren" statt "ihrem" überschreibt das "n" als Akkusativmarker (des Artikels?) die Dativflexion im Singular. Diese ist dann identisch mit dem Dativ Plural. Es handelt sich also, wenn man so will, um "Pseudo-Akkusative". Diese Frage behandele ich in der nächsten Vorlesung.Präsentation (*.pdf): Alexander Lasch. 2026. Grammatik in der Schule. Zenodo. DOI: ⁠⁠⁠⁠⁠⁠https://doi.org/10.5281/zenodo.19236685⁠⁠⁠⁠⁠⁠. Videoaufzeichnungen: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://youtube.com/@AlexanderLasch⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Informationen & Material zu allen Vorlesungen: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.gls-dresden.de/tag/podcast_vorlesung/⁠⁠⁠⁠⁠⁠⁠⁠. Worksheet zu den Vorlesungen: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://docs.google.com/document/d/1NH1z5FwzCmA6UOAjwRrhZEDe5fo3Lmq5-3xDLlM2B7Y/edit?tab=t.99a8y21twmjz⁠⁠. Intro: "Reflections" von Scott Holmes (CC BY via ⁠⁠⁠⁠⁠⁠FMA⁠⁠⁠⁠⁠⁠).#Linguistik #OER #Sprache #Sprachwissenschaft #Grammatik #Konstruktionsgrammatik #Konstruktionsdikdatik

In this session, we explore how persistent identifiers and open research infrastructure are transforming research visibility and discoverability across Africa.Mohamad Mostafa (DataCite) opens with an overview of the 2021 UNESCO Recommendation on Open Science, particularly its second pillar on open research infrastructure and explains how tools like DOIs, ORCID IDs, and ROR IDs work together to make research outputs findable, accessible, interoperable, and reusable (FAIR). He walks through DataCite's global community of over 1,700 member organizations across 69 countries, its Fabrica platform for DOI registration, and the consortium model that makes adoption cost-effective for institutions across Eastern and Southern Africa through the UbuntuNet Alliance.Ahmed Siyad (CEO, SomaliREN) then shares the story behind SORER — the Somali Research and Education Repository — a centralized, multi-institutional platform built to address low research visibility, plagiarism concerns, and limited access to global scholarly infrastructure. He covers how SomaliREN integrated DOI minting through the DataCite/UbuntuNet consortium, adopted ORCID IDs, established the Somali Identity Federation (SIF), and achieved FAIR compliance — making Somali research outputs accessible and interoperable on a global scale.The session also touches on the importance of hosting research infrastructure on the African continent itself, in line with the CARE Principles and the mission of AfricArXiv.This webinar is part of the AfricArXiv Open Science Webinar Series, supported by Invest in Open Infrastructure and co-organized by UbuntuNet Alliance and Access to Perspectives.Learn more and access past webinars at www.africarxiv.orgFollow for future sessions on open access, persistent identifiers, open science policy, and more.#openscience #PersistentIdentifiers #openaccess #data #research

We are a decade into the CAR-T era, and what to long term outcomes look like with tisagenlecleucel in B-cell lymphomas? Orca-T is approved, an allogenic cocktail of stem & progenitor cells, Tregs, and then conventional T-cells. Neato. Polar-Go! or PolARGo? And the concept of T-cell "stemless" is intriguing with possibilities: DOI: 10.1056/NEJMcibr2601002 Learning Oncology Companion:https://www.kelleycpharmd.com/learning-oncology-companion-oncopharm

BUFFALO, NY — July 7, 2026 — A new #review was #published in Volume 18 of Aging on June 22, 2026, titled “The multifaceted inducers of cellular senescence.” The review was led by first author Hilah Gal and corresponding author Valery Krizhanovsky from the Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. Cellular senescence is a fundamental biological process in which damaged or stressed cells permanently stop dividing while remaining metabolically active. This response plays an essential role in suppressing tumor formation, supporting embryonic development, facilitating wound healing, and maintaining tissue integrity. However, as people age, senescent cells accumulate because they are no longer efficiently cleared by the immune system. Their persistence contributes to chronic inflammation, tissue dysfunction, cancer, and many age-related diseases. In this comprehensive review, the authors examine the diverse biological stimuli that trigger cellular senescence and describe how seemingly different stimuli ultimately converge on common molecular pathways that establish stable growth arrest. Rather than viewing senescence as a single process, the review emphasizes its remarkable biological diversity and the importance of understanding how different initiating events shape distinct senescent cell phenotypes. The review discusses several major biological inducers of cellular senescence. One of the best-established mechanisms is telomere attrition, in which repeated cell division gradually shortens chromosome ends until they trigger a persistent DNA damage response. Other important stimuli include direct DNA damage caused by ionizing radiation, ultraviolet light, chemotherapy, and oxidative injury, all of which activate cellular pathways that permanently halt proliferation. Full press release - https://aging-us.net/2026/07/07/multiple-biological-triggers-shape-cellular-senescence-in-aging-and-disease/ DOI - https://doi.org/10.18632/aging.206391 Corresponding author - Valery Krizhanovsky - valery.krizhanovsky@weizmann.ac.il Abstract video - https://www.youtube.com/watch?v=5Y7R_8GQ1gk Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206391 Keywords - aging, cell senescence To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY – July 6, 2026 – A new #casereport was #published in Volume 17 of Oncotarget on July 2, 2026, titled “Renal oncocytoma: Α case report and literature review.” The study was led by first and corresponding author Areti Kalfoutzou from the Second Propaedeutic Department of Internal Medicine, Attikon General Hospital, National and Kapodistrian University of Athens, Greece. Renal oncocytoma is a rare benign tumor of the kidney that accounts for approximately 5–9% of renal epithelial tumors. Although it is considered benign, it often resembles kidney cancer on imaging studies, making accurate diagnosis challenging. Because treatment strategies differ substantially between benign oncocytoma and malignant renal tumors, establishing the correct diagnosis is essential to avoid unnecessary surgery while ensuring appropriate patient care. In this report, the researchers describe the case of an 82-year-old woman who presented with two months of gross hematuria. Contrast-enhanced computed tomography (CT) identified a 55 × 34 mm exophytic lesion arising from the upper pole of the left kidney. Based on its imaging characteristics, the mass was initially classified as a Bosniak category IV renal lesion, raising strong suspicion for renal malignancy. Full press release - https://www.oncotarget.net/2026/07/06/rare-benign-kidney-tumor-case-highlights-value-of-biopsy-and-minimally-invasive-treatment/ DOI - https://doi.org/10.18632/oncotarget.28893 Correspondence to - Areti Kalfoutzou - areti.kalfoutzou@haf.gr Abstract video - https://www.youtube.com/watch?v=C7TBLT3tbfA Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28893 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, cryoablation, image-guided biopsy, kidney neoplasms, minimally invasive surgery, renal oncocytoma To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY — July 6, 2026 — A new systematic #review was #published in Volume 18 of Aging on June 18, 2026, titled “Life expectancy and causes of death in classical laminopathic progeroid syndromes: systematic review with individual-patient data synthesis.” The study was led by co-first authors Carlos López-Vila, Manuel García-Cordeiro, and Luís Estévez-Martínez from the University of Santiago de Compostela, and corresponding author David Araújo-Vilar from the University of Santiago de Compostela and the University Clinical Hospital of Santiago de Compostela, Spain. Classical laminopathic progeroid syndromes are among the rarest inherited disorders known. Caused by mutations affecting the LMNA gene or the ZMPSTE24 enzyme, these conditions lead to premature aging, severe multisystem disease, and markedly shortened life expectancy. Although Hutchinson-Gilford progeria syndrome (HGPS), mandibuloacral dysplasia (MAD), and restrictive dermopathy (RD) all belong to this group, reliable information about survival and causes of death for each disorder has remained limited because most published reports describe only individual patients or small case series. In this study, researchers performed a comprehensive systematic review and individual-patient data analysis to date of classical laminopathic progeroid syndromes. Following PRISMA guidelines, they analyzed data from 169 published studies together with two additional genetically confirmed institutional cases, creating a cohort of 158 genetically confirmed patients for the primary survival analysis. By examining individual patient records rather than pooled summaries, the investigators were able to compare survival patterns and causes of death across each disease subtype with greater precision. Full press release - https://aging-us.net/2026/07/06/comprehensive-individual-patient-analysis-clarifies-life-expectancy-across-rare-progeria-disorders/ DOI - https://doi.org/10.18632/aging.206389 Corresponding author - David Araújo-Vilar - david.araujo@usc.es Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206389 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, progeria, Lamin A/C (LMNA), ZMPSTE24, survival, cause of death To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

As people live longer, maintaining good health is becoming just as important as extending lifespan. While chronological age simply reflects the number of years a person has lived, biological age measures how well the body is functioning and may better predict future health. Researchers have increasingly focused on lifestyle factors that may slow biological aging, and diet has emerged as one of the most promising. A research paper published in Volume 18 of Aging titled “Plant-based dietary patterns are associated with slower epigenetic aging,” investigated whether diets emphasizing plant foods are associated with slower biological aging as measured by DNA methylation-based epigenetic clocks. Full blog post - https://aging-us.org/2026/07/plant-based-dietary-patterns-are-associated-with-slower-biological-aging/ DOI - https://doi.org/10.18632/aging.206362 Corresponding author - Hyunju Kim - hyunjuk1@uw.edu Abstract video - https://www.youtube.com/watch?v=FcJ7oEZ-KFk Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206362 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, plant-based diets, DNA methylation, epigenetic aging, all-cause mortality, middle-aged adults To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

In dieser Vorlesung widmen wir uns der Frage, wie im Deutschen sprachlich Zukunft konzeptualisiert wird. Das „Futur“ jedenfalls als reine grammatische Zeitform aus werden + Infinitiv ist weder theoretisch noch analytisch zu halten. Denn neben dieser Form wird Nachzeitigkeit vielmehr auch durch ein komplexes Zusammenspiel aus der unmarkierten Gegenwartsform (Präsens), Temporaladverbialien (morgen, bald) sowie der Aktionsart der verwendeten Verben (telische Verben) hergestellt. Anhand von Beispielen aus traditionellen Schulmaterialien (OER-Plattformen) und Korpusdaten wird aufgezeigt, dass die Struktur werden + Infinitiv primär der Faktizitätsmarkierung dient (Ausdruck von Ungewissheit oder Vermutung). Die Vorlesung plädiert für einen konstruktionsgrammatischen und empirischen Ansatz im Deutschunterricht, der Schülern die tatsächliche Komplexität von Sprache abseits eines starren Tempussystems vermittelt.Präsentation (*.pdf): Alexander Lasch. 2026. Grammatik in der Schule. Zenodo. DOI: ⁠⁠⁠⁠⁠https://doi.org/10.5281/zenodo.19236685⁠⁠⁠⁠⁠. Videoaufzeichnungen: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://youtube.com/@AlexanderLasch⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Informationen & Material zu allen Vorlesungen: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.gls-dresden.de/tag/podcast_vorlesung/⁠⁠⁠⁠⁠⁠⁠. Worksheet zu den Vorlesungen: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://docs.google.com/document/d/1NH1z5FwzCmA6UOAjwRrhZEDe5fo3Lmq5-3xDLlM2B7Y/edit?tab=t.99a8y21twmjz⁠. Intro: "Reflections" von Scott Holmes (CC BY via ⁠⁠⁠⁠⁠⁠FMA⁠⁠⁠⁠⁠⁠).#Linguistik #OER #Sprache #Sprachwissenschaft #Grammatik #Konstruktionsgrammatik #Konstruktionsdikdatik

Doi dintre semnatarii volumului „Suveranismul în România", Alina Pop și Filip Alexandrescu, demontează un mit colectiv: votul suveranist nu aparține exclusiv celor vulnerabili financiar, ci este un semnal de alarmă din partea celor care simt că „le merge rău". În spatele opțiunilor de vot din ultimii ani se ascund realități dure: muncă precară, venituri nesigure și sentimentul de abandon. Atunci când politicienii vin cu discursuri simple la probleme complexe și cu empatie aparentă („Vă înțeleg, vă văd lacrimile"), electoratul din cele „patru Românii" (de la marile orașe la ruralul mic) reacționează. Cum s-a format profilul acestor votanți și ce soluții (netestate) i-au atras? 00:03:25 "Suveranismul în România. De ce votează oamenii cu politicieni extremişti?" volum scris de Alina Pop, Filip Alexandrescu și Ionuț-Marian Anghel, editura Humanitas 00:05:39 Cine sunt oamenii care votează cu AUR, SOS, POT, Călin Georgescu și George Simion 00:07:05 Ideea ne-a venit în decembrie 2024 00:10:10 Răspuns la mesajele politicienilor 00:13:50 Candidatul necunoscut 00:20:15 Patimă… pe alocuri 00:26:05 2 sau mai multe Românii? 00:36:40 Curent anti-elitist 00:39:21 Punem egal între suveranism și extremă dreaptă? 00:44:45 Munca de teren e valoroasă 00:54:20 "Găselnița" suveranismului 01:02:50 Discurs simplu la probleme complexe, tipicul discursului populist 01:18:57 Roșia Montană 01:32:09 Războiul din Ucraina și empatia românilor. Nu suntem o miză pentru Putin 01:39:07 Nostalgie după comunism 01:53:10 Politicienii să-și facă timp să-i asculte pe cetățeni

What's the episode about? In this episode, hear Dr Molly Conisbee on social histories of death and mourning, liberation thanatology, lessons fromthe history of death, walking tours and being a bereavement councillorWho is Molly? Molly Conisbee is a social historian and visiting research fellow at the Centre for Death and Society at the University of Bath.  She has a PhD from the University of Bristol and has spent the last ten years researching the social history of death and mourning.  Conisbee is also a bereavement counsellor, has curated walks on the history of death around the country and has written for the Guardian and Ecologist.To cite this episode, you can use the following citation: Conisbee, M. (2026) Interview on The Death Studies Podcast hosted by Michael-Fox, B. and Visser, R.Published 1 July 2026. Available at: www.thedeathstudiespodcast.com, DOI: 10.6084/m9.figshare.32866145

BUFFALO, NY — July 1, 2026 — A new #review was #published in Volume 18 of Aging on June 11, 2026, titled “Age-related dysfunctions of the neuroendocrine axes in nonhuman primates with depression-like and anxious behavior.” The review, dedicated to the late Dr. Mikhail (Misha) Blagosklonny, was written by Nadezhda D. Goncharova from the Kurchatov Complex of Medical Primatology, National Research Center “Kurchatov Institute,” Adler, Sochi, Russian Federation. As people grow older, their risk of developing stress-related disorders—including depression, metabolic disease, cardiovascular disease, cognitive decline, and neurodegenerative conditions—increases substantially. However, not everyone ages in the same way. Some individuals appear more resilient to stress, while others develop endocrine and metabolic disturbances that may accelerate aging and disease. Understanding the biological mechanisms behind these differences could help identify people at greater risk and support more personalized approaches to healthy aging. In this review, the author summarizes decades of experimental research investigating how aging affects two major neuroendocrine systems—the hypothalamic-pituitary-adrenal (HPA) axis and the hypothalamic-pituitary-thyroid (HPT) axis—in nonhuman primates displaying either typical adaptive behavior or depression-like and anxiety-like behavior. Because rhesus monkeys closely resemble humans in their physiology, endocrine function, and behavior, they provide a valuable translational model for studying age-related changes that are difficult to examine in people. The research shows that older monkeys with depression-like and anxiety-like behavior develop more pronounced dysfunction of the HPA axis than animals with standard behavior. These animals exhibited impaired negative feedback regulation, higher evening and nighttime cortisol levels, increased responses to acute stress, and greater activation of stress-related hormonal pathways. Together, these findings suggest impaired regulation of stress responses during aging. The review also describes important age-related alterations in thyroid function. Older animals with depression-like and anxiety-like behavior showed lower thyroxine secretion, diminished thyroid responsiveness to hormonal stimulation, and evidence of impaired thyroid gland function. These endocrine changes were accompanied by greater insulin resistance, altered triglyceride metabolism, and reduced insulin secretion in overweight animals, indicating that stress-related neuroendocrine dysfunction may extend well beyond the brain. Importantly, the findings suggest that behavioral characteristics may influence how endocrine systems age. Rather than experiencing identical biological changes over time, individuals with greater vulnerability to stress may develop more severe hormonal disturbances that contribute to age-related disease. Full press - https://aging-us.net/2026/07/01/nonhuman-primate-research-reveals-how-aging-stress-and-behavior-may-interact-to-increase-disease-risk/ DOI - https://doi.org/10.18632/aging.206388 Corresponding author - Nadezhda D. Goncharova - ndgoncharova@mail.ru (ORCID id: 0000-0002-2720-9846) Abstract video - https://www.youtube.com/watch?v=yj8zvthBiA4 To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Additional Resources:  Hess J, Comeau M, Casperson S ..., Dietary Guidelines Meet NOVA: Developing a Menu for A Healthy Dietary Pattern Using Ultra-Processed Foods, The Journal of Nutrition, 2023; 153, 2472-2481 Latulippe, Marie E. MS, MBA, RDN; Hultin, Ginger DCN, RDN. Highly Processed and Ultra-Processed Foods and Health: Balancing Evidence and Everyday Eating. Nutrition Today 61(3):p 115-121, May/June 2026. | DOI: 10.1097/NT.0000000000000809  Listen to more episodes of Diabetes Care Conversations at https://www.adces.org/practice/the-huddle-podcastLearn more about ADCES and the many benefits of membership at adces.org/join.The Diabetes Care Conversations Podcast is edited by JAG Podcast Productions: https://jagpodcastproductions.com/ Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Ken Jensen describes his background in environmental toxicology and medical devices, then argues morality can be grounded without religion. He traces a “true, good, beautiful” triad from Plato through Vitruvius and maps it to objective reality, reciprocity/voluntary exchange, and beauty/grace, contrasting it with a destructive “DOI” (destruction, opposition, inversion) force. He critiques management tactics like permanent crisis, “red dot” diversions, and misuse of Romans 13, citing Katrina clergy response teams. He promotes a “dartboard” model over left-right politics, says ethics and morality are inseparable (Nuremberg vs Nazi view), warns about EU-style centralization, CBDCs, and praises ridicule as a defense. He discusses sound money and presents his books The Enemies of Reason and The Memo.00:00 Meet Ken Jensen01:02 Morality Without God02:23 Early Doubts and Clues05:13 Climate Debate and First Principles06:15 Entropy Uppers and Downers09:02 Religion as Binding Core10:46 Words Shape Thought13:38 Plato Truth Good Beauty17:47 Rome Constantine and Control20:26 Katrina Clergy Response Teams23:12 Triad Mapped to Trinity29:02 Dorothy Model and Inversion30:43 Universities and Private Property34:57 Aesthetics vs Brutalism35:35 Destruction Opposition Inversion36:04 Parasitic Tactics Explained36:59 Inverting the Trinity37:27 Defining What We Defend38:12 Two Books Overview38:57 Dartboard Not Left Right41:04 Morality vs Legal Positivism43:13 Takeaways Recalibration46:37 Studying Evil and Pride49:34 Red Dot Diversions51:17 Wizard of Oz Q and A51:48 CBDCs and EU Centralization56:57 Permanent Crisis and Elites58:33 Ressentiment and Ridicule01:01:20 Sound Money Fixes Society01:04:17 Wrap Up and Contactshttps://www.linkedin.com/in/kpjensen/https://www.contactauthorkpj.com/=========Slides, summaries, references, and transcripts of my podcasts: https://tomn.substack.com/p/podcast-summariesMy Linktree: https://linktr.ee/tomanelson1

Tessa campisi speaks to Jack Manera, who studies behavial ecology and ecotoxicology at Monash University, to talk about some of his ~amazing~ experiments investigating the impacts of pharmaceutical contaminants on how fish think. Read up on Jack's other research: www.jackmanera.comDonate to Out of the Blue this radiothon!www.givenow.com.au/cr/outoftheblue2026 Image credit: Jack L. Manera, Eleanor R. Moore, Jake M. Martin, Michael G. Bertram, and Bob B. M. Wong, Environmental Science & Technology 2026 60 (14), 10640-10650. DOI: 10.1021/acs.est.6c00552

This week we review a recent meta-analysis of studies assessing efficacy of adenosine in children to terminate SVT. Does the PALS recommendation of 100 mcg/kg as a starting dose for SVT management make scientific sense given what we know about the efficacy rates of this dose? Why might inadequate doses be potentially dangerous for children with acute SVT? Is there adequate data to consider changes to the recommended starting dose in this situation? Dose adenosine work well for all forms of tachycardia involving the AV node? Pediatric emergency physician and family medicine physician, Dr. Lais dos Santos of Mossoro', Brazil shares the results of a large scale meta-analysis that she performed and offers some answers to these and other questions. DOI: 10.1007/s00246-026-04281-5

This week we discuss a new approval for pabociclib in HER2-positive disease based on the PATINA trial as well as the use of sacituzumab govitecan + pembrolizumab in TNBC, recently approved based on the ASCENT04/KEYNOTED19 trial. And the concept of T-cell "stemless" is intriguing with possibilities: DOI: 10.1056/NEJMcibr2601002 Learning Oncology Companion: https://www.kelleycpharmd.com/learning-oncology-companion-oncopharm

In this episode, Thomas K Varghese, Jr, MD, FACS, is joined by Serena Lofftus, MD, and James Wu, MD, FACS, from UCLA. They discuss Drs Lofftus and Wu's recent article, “Patient-Based Decision Making for Opioid Prescriptions After Ambulatory Breast Operation: A Randomized Clinical Trial,” which evaluated whether incorporating patient choice into postoperative prescribing decisions could reduce opioid prescribing and consumption after ambulatory breast operation without negatively affecting pain control or quality of life.   Disclosure Information: Drs Varghese, Lofftus, and Wu have no relevant financial conflicts of interest to disclose.   To earn 0.25 AMA PRA Category 1 Credits™ for this episode of the JACS Operative Word Podcast, click here to register for the course and complete the evaluation. Listeners can earn CME credit for this podcast for up to 2 years after the original air date.   Lofftus, Serena Y MD1,4; Graham, Danielle S MD, PhD1,4; Le, Julie MD, FACS1,2; Zhu, Catherine Y MD1,3; Kaufman, Noy MD4,5; Huy, Tess C MD1,4; Kusske, Amy M MD, FACS1,4; Teshome, Mediget MD, FACS1,4; Baker, Jennifer L MD, FACS1,4; Wu, James X MD, FACS4,6. Patient-Based Decision Making for Opioid Prescriptions After Ambulatory Breast Operation: A Randomized Clinical Trial. Journal of the American College of Surgeons ():10.1097/XCS.0000000000001974, April 13, 2026. | DOI: 10.1097/XCS.0000000000001974   Learn more about the Journal of the American College of Surgeons, a monthly peer-reviewed journal publishing original contributions on all aspects of surgery, including scientific articles, collective reviews, experimental investigations, and more.   #JACSOperativeWord

In this episode of Astronomy Daily, Anna and Avery explore six remarkable stories from the frontiers of space science. JWST has determined that interstellar comet 3I/ATLAS likely formed 10–12 billion years ago — before our Sun existed — making it the oldest object ever chemically characterised. NASA's Perseverance rover has delivered its most robust organic detection yet in Mars's Jezero Crater. ESA's Euclid telescope has released the largest and most detailed visible-light image ever taken of the Milky Way's galactic bulge. NASA's plan to deorbit the ISS into the Pacific Ocean faces new legal and environmental scrutiny. Research from the University of Glasgow reveals the Chicxulub impact crater hosted an underground hydrothermal system for eight million years — four times longer than previously estimated. And astronomers have discovered the first-ever pair of sibling supernova remnants, hiding in the glow of the famous Jellyfish Nebula.   Story 1 — JWST & 3I/ATLAS Origin • Cordiner et al. (2026). 'Isotopic evidence for a cold and distant origin of 3I/ATLAS.' Nature. DOI: 10.1038/s41586-026-10771-6 • Opitom et al. (2026). 'High nitrogen and carbon isotopic ratios in the interstellar comet 3I/ATLAS.' Nature (in press). arXiv: 2603.07187 • NASA Science: https://science.nasa.gov/missions/webb/nasas-webb-finds-clues-to-ancient-distant-origin-of-comet-3i-atlas/ • Science Magazine: https://www.science.org/content/article/interstellar-comet-unlike-anything-seen-our-solar-system   Story 2 — Perseverance Organic Detection • Murphy et al. (2026). 'Spatially distributed complex organic matter detected in an ancient river valley in Jezero crater, Mars.' Science Advances. DOI: 10.1126/sciadv.adx0047 • Space.com: https://www.space.com/astronomy/mars/did-nasa-just-find-evidence-of-ancient-life-on-mars-perseverance-rover-spots-complex-carbon-in-red-planet-rocks • ScienceAlert: https://www.sciencealert.com/perseverance-finds-complex-organic-compounds-in-strange-mars-rocks   Story 3 — Euclid Milky Way Image • ESA Euclid Mission Press Release, 24 June 2026 • NASA JPL: https://www.nasa.gov/missions/roman-space-telescope/euclid-view-of-milky-way-heart-previews-core-survey-by-nasas-roman/ • Space.com: https://www.space.com/astronomy/galaxies/this-is-the-largest-and-most-detailed-image-of-our-milky-way-with-over-60-million-stars-and-50-exoplanet-systems • CBS News: https://www.cbsnews.com/news/euclid-telescope-most-detailed-image-milky-way-stars/   Story 4 — ISS Deorbit Environmental Concerns • US Government Accountability Office report on ISS deorbit, June 2026 • Space.com: https://www.space.com/space-exploration/international-space-station/nasa-wants-to-dump-the-iss-in-the-sea-experts-say-the-plan-raises-serious-concerns-for-ocean-health • The Ocean Foundation statement, June 2026   Story 5 — Chicxulub Hydrothermal System • Pickersgill et al. (2026). 'Hydrothermal activity persisted for at least 8 Myr at Chicxulub.' Communications Earth & Environment. DOI: 10.1038/s43247-026-03618-5 • Phys.org: https://phys.org/news/2026-06-dino-asteroid-fueled-underground-life.html • EarthSky: https://earthsky.org/earth/dinosaur-killing-asteroid-underground-hydrothermal-habitat/   Story 6 — Jellyfish Nebula Sibling Remnant • Astrophysicists' paper on IC 443 sibling supernova remnant, Universe Today, June 23 2026 • Universe Today: https://www.universetoday.com/Become a supporter of this podcast: https://www.spreaker.com/podcast/astronomy-daily-the-latest-space-news--5648921/support.Sponsor Details:Ensure your online privacy by using NordVPN. To get our special listener deal and save a lot of money, visit www.bitesz.com/nordvpn. You'll be glad you did!Become a supporter of Astronomy Daily by joining our Supporters Club. Commercial free episodes daily are only a click way... Click HereThis episode includes AI-generated content.

BUFFALO, NY — June 25, 2026 — A new #research paper was #published in Volume 18 of Aging on May 29, 2026, titled “Short-term responsiveness of DNA methylation–based aging biomarkers to a multimodal intervention comprising exercise and dietary guidance involving daily consumption of yogurt containing Bifidobacterium longum BB536: an exploratory randomized controlled trial.” The study, selected as our Editors' Choice, was led by first author Tatsuki Nishimura and corresponding author Yukihiro Hishida from the R&D Division of Morinaga Milk Industry Co., Ltd., Japan. As researchers continue searching for practical ways to promote healthy aging, increasing attention has focused on interventions that target multiple biological pathways simultaneously. While exercise and healthy eating are widely recognized as important components of healthy aging, scientists are also investigating whether specific dietary components and gut microbes may influence biological aging processes measurable at the molecular level. In this study, researchers evaluated whether a 12-week lifestyle program could affect DNA methylation–based biomarkers of aging in overweight men aged 50 years and older. The intervention combined individualized exercise guidance, dietary counseling, and daily consumption of yogurt containing Bifidobacterium longum BB536, a probiotic strain that has previously been linked to beneficial effects on inflammation and gut health. The randomized controlled trial enrolled 48 participants, who were assigned either to the intervention group or to a control group that maintained their usual lifestyle habits. Participants in the intervention group received dietary counseling focused on reducing overeating, exercise guidance encouraging regular walking or stepper-based activity, and a daily serving of yogurt containing Bifidobacterium longum BB536. To assess biological aging, the investigators measured several DNA methylation–based aging biomarkers before and after the 12-week intervention. Particular attention was given to DunedinPACE, an epigenetic measure designed to estimate the current pace of biological aging rather than biological age itself. Full press release - https://aging-us.net/2026/06/25/lifestyle-intervention-linked-to-slower-biological-aging-markers-in-older-men/ DOI - https://doi.org/10.18632/aging.206386 Corresponding author - Yukihiro Hishida - yukihiro-hishida639@morinagamilk.co.jp Abstract video - https://www.youtube.com/watch?v=7W5sDpGgZtE Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206386 Keywords - aging, DNA methylation clock, DunedinPACE, Multicomponent lifestyle intervention, Bifidobacterium longum BB536 To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY – June 24, 2026 – A new research paper was published in Volume 17 of Oncotarget on June 9, 2026, titled “TRAIL-R2 in the shadows: Epigenetic silencing and clinical implications in breast cancer.” The study was led by first author Nuzhat Khursheed from the University of Kashmir and corresponding authors Asia Asiaf from the Central University of Kashmir and Showkat Ahmad Ganie from the University of Kashmir. Breast cancer remains one of the most common cancers affecting women worldwide. While advances in diagnosis and treatment have improved outcomes for many patients, researchers continue to investigate the molecular changes that enable tumor cells to survive, grow, and spread. One process receiving increasing attention is epigenetic regulation, in which genes are switched on or off without altering the underlying DNA sequence. In this study, researchers examined TRAIL-R2, also known as death receptor 5 (DR5), a protein that plays an important role in triggering apoptosis, the programmed cell death process that helps eliminate damaged or abnormal cells. Loss of apoptotic signaling is a hallmark of cancer, but the clinical significance and epigenetic regulation of TRAIL-R2 in breast cancer have remained incompletely understood. The investigators analyzed matched tumor and adjacent normal breast tissue samples from 67 patients. Using methylation-specific PCR, quantitative real-time PCR, and western blotting, they evaluated TRAIL-R2 promoter methylation as well as its gene and protein expression levels. The analysis revealed that TRAIL-R2 was frequently silenced in breast tumors. More than half of tumor samples showed promoter hypermethylation, a chemical modification that can suppress gene activity. At the same time, both TRAIL-R2 mRNA and protein expression levels were significantly lower in tumor tissues than in adjacent normal breast tissue. Further analysis demonstrated that TRAIL-R2 hypermethylation was more common in invasive ductal carcinoma, the most common subtype of breast cancer, and in patients with a history of oral contraceptive use. Reduced TRAIL-R2 expression was also associated with advanced tumor stage and several clinicopathological features linked to more aggressive disease. The researchers observed a strong inverse relationship between promoter methylation and TRAIL-R2 expression, suggesting that epigenetic silencing may contribute directly to loss of this important apoptotic receptor. Tumors with reduced TRAIL-R2 activity may become less susceptible to programmed cell death, potentially allowing cancer cells to survive and progress. Full press release - https://www.oncotarget.net/2026/06/24/trail-r2-silencing-linked-to-more-aggressive-breast-cancer/ DOI - https://doi.org/10.18632/oncotarget.28891 Correspondence to - Asia Asiaf - asiaf29@cukashmir.ac.in, and Showkat Ahmad Ganie - showkatganie@kashmiruniversity.ac.in Abstract video - https://www.youtube.com/watch?v=BvhkOYLTJUY Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28891 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, TRAIL-R2/DR5, promoter methylation, breast cancer biomarkers, tumor suppressor gene, apoptotic signalling pathways To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Send us Fan MailAs Diretrizes 2026 do Programa Brasileiro de Reanimação Neonatal acabaram de ser publicadas — e neste episódio a gente vai trazer as novidades.Percorremos os dois documentos lançados pela SBP em 12 de junho de 2026: as diretrizes para recém-nascidos com 34 semanas ou mais e as diretrizes para prematuros com menos de 34 semanas. Discutimos o que mudou em relação a 2022, o que foi reforçado e o que é novidade estrutural — do briefing ao debriefing, do clampeamento tardio ao escalonamento de oxigênio por faixa gestacional, do CPAP na sala de parto à abordagem ética nos limites da viabilidade.E fazemos isso ao lado do NRP 9ª edição, as diretrizes americanas de 2025 da AHA e AAP — que você conheceu no episódio 66 — para entender onde Brasil e Estados Unidos convergem e onde, deliberadamente, divergem.Almeida MFB, Guinsburg R et al. Reanimação do RN ≥34 semanas: Diretrizes SBP 2026. DOI: 10.25060/PRN-SBP-2026-1  https://www.sbp.com.br/?acervo_download=1&post_id=62422&nonce=942dd601abGuinsburg R, Almeida MFB et al. Reanimação do RN

BUFFALO, NY — June 23, 2026 — A new #research paper was #published in Volume 18 of Aging on May 28, 2026, titled “p38MAP kinase regulates senescence in human iPS-derived myocytes.” The study was led by first author Hiroki Sato and corresponding author Ryuichiro Sato from The University of Tokyo, along with corresponding author Makoto Shimizu from The University of Tokyo and Ochanomizu University. As people age, skeletal muscle gradually loses strength, mass, and function, contributing to frailty, reduced mobility, and an increased risk of falls. Although cellular senescence is widely recognized as a major driver of aging, the mechanisms that promote aging within mature muscle fibers remain poorly understood. In this study, researchers developed a human cell-based model to investigate how senescence develops in skeletal muscle cells and identified a signaling pathway that appears to play a central role in the process. The research team used human induced pluripotent stem cell (iPSC)-derived myocytes, specialized muscle cells generated from stem cells. To mimic age-related cellular damage, the investigators exposed the cells to low-dose X-ray irradiation, which induced DNA damage without causing extensive cell death. The treated muscle cells developed several characteristics commonly associated with aging. They exhibited muscle fiber atrophy, reduced contractile activity, and increased expression of p21, a well-established marker of cellular senescence. The researchers also observed elevated production of senescence-associated secretory phenotype (SASP) factors, inflammatory and extracellular signaling molecules that are commonly released by senescent cells. To better understand the molecular changes involved, the investigators performed proteomic, transcriptomic, and functional analyses. These studies revealed activation of p38 mitogen-activated protein kinase (p38MAPK), a signaling pathway previously linked to cellular stress responses and aging in other tissues. Further experiments demonstrated that inhibiting p38MAPK partially attenuated several senescence-associated features in the muscle cells. Treatment with p38MAPK inhibitors reduced muscle fiber atrophy, improved contractile function, and suppressed the expression of several senescence-associated factors. Conversely, activating p38MAPK promoted aging-like changes in the cells, further supporting its role in regulating muscle cell senescence. The study also identified activation of an integrin–FAK/SRC–p38MAPK signaling axis following DNA damage. According to the authors, this pathway may help explain how cellular stress is translated into long-term functional decline in skeletal muscle. Importantly, the findings were supported by analyses of human muscle aging datasets, which showed increased activity of MAPK signaling, focal adhesion pathways, and cytokine-related signaling in older skeletal muscle tissue. Full press release - https://aging-us.net/2026/06/23/researchers-identify-key-signaling-pathway-driving-muscle-cell-aging/ DOI - https://doi.org/10.18632/aging.206385 Corresponding authors - Ryuichiro Sato - roysato@g.ecc.u-tokyo.ac.jp, and Makoto Shimizu - shimizu.makoto@ocha.ac.jp Abstract video - https://www.youtube.com/watch?v=ULm7R74CJx0 Website - https://www.Aging-US.com​​ Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

As colorectal cancer rates rise among younger adults, surgeons are increasingly caring for patients with rectal cancer who are pregnant or hoping to preserve future fertility. With more individuals delaying childbearing, balancing effective cancer treatment with fertility preservation and maternal–fetal safety has become an important clinical challenge. This timely topic was recently highlighted by Dr. Sharon Suwanabol during a presentation at the American Society of Colon and Rectal Surgeons annual meeting 2026. In this episode, we explore the intersection of rectal cancer, fertility, and pregnancy through a multidisciplinary, case-based discussion. We review how surgery, chemotherapy, and pelvic radiation can affect fertility and sexual function in both men and women, and why early counseling and referral to reproductive endocrinology specialists are essential. The discussion also emphasizes that evaluation and treatment during pregnancy can often be performed safely, with care individualized based on tumor stage, gestational age, and the patient's goals and values. Hosts and discussants ·      Dr. Betelhem Yohannes, General surgery resident at the University of Washington ·      Dr. Griffen Allen, General surgery resident at the University of Washington  ·      Dr. Raga Siddharthan, Assistant Professor of Surgery in the Section of Colorectal Surgery at the University of Washington  ·      Dr. Stacey Cohen, Professor in the Division of Hematology and Oncology at the University of Washington and a gastrointestinal medical oncologist at Fred Hutch Cancer Center, specializing in colorectal and other GI cancers. Learning objectives ·      Describe the impact of rectal cancer surgery on fertility, sexual function, and future childbearing potential. ·      Review the effects of chemotherapy and pelvic radiation on reproductive health and fertility preservation. ·      Discuss available fertility preservation strategies and the importance of early pre-treatment counseling and referral. ·      Recognize the diagnostic challenges of rectal cancer during pregnancy, including overlapping gastrointestinal symptoms. ·      Review appropriate staging and workup considerations for suspected rectal cancer in pregnant patients. ·      Discuss multidisciplinary management strategies for rectal cancer during pregnancy, including individualized treatment sequencing. ·      Examine ethical and patient-centered considerations when balancing maternal cancer treatment and fetal outcomes. References  Siegel RL, Wagle NS, Star J, Kratzer TB, Smith RA, Jemal A. Colorectal cancer statistics, 2026. CA Cancer J Clin. 2026;76(2):e70067. doi:10.3322/caac.70067 [https://pubmed.ncbi.nlm.nih.gov/38240409/] Pregnancy at Age 35 Years or Older: ACOG Obstetric Care Consensus No. 11. Obstet Gynecol. 2022;140(2):348-366. doi:10.1097/AOG.0000000000004873 [https://pubmed.ncbi.nlm.nih.gov/35640237/] Stal J, YI SY, Cohen-Cutler S, et al. Fertility Preservation Discussions Between Young Adult Rectal Cancer Survivors and Their Providers: Sex-Specific Prevalence and Correlates. Oncologist. 2022;27(7):579-586. doi:10.1093/oncolo/oyac052 [https://pubmed.ncbi.nlm.nih.gov/35708892/] Druvefors E, Myrelid P, Andersson RE, Landerholm K. Female and Male Fertility after Colectomy and Reconstructive Surgery in Inflammatory Bowel Disease: A National Cohort Study from Sweden. J Crohns Colitis. 2023;17(10):1631-1638. doi:10.1093/ecco-jcc/jjad079 [https://pubmed.ncbi.nlm.nih.gov/37341355/] Ito M, Tsukada Y, Watanabe J, et al. Long-term survival and functional outcomes of laparoscopic surgery for clinical stage I ultra-low rectal cancers located within 5 cm of the anal verge: A prospective phase II trial (Ultimate trial). Ann Surg. Published online April 1, 2024. doi:10.1097/SLA.0000000000006290 [https://pubmed.ncbi.nlm.nih.gov/38629555/] Teh WT, Stern C, Chander S, Hickey M. The impact of uterine radiation on subsequent fertility and pregnancy outcomes. Biomed Res Int. 2014;2014:482968.  Johnson GGRJ, Park J, Helewa RM, Goldenberg BA, Nashed M, Hyun E. Total neoadjuvant therapy for rectal cancer: a guide for surgeons. Can J Surg. 2023 Apr 21;66(2):E196-E201. doi: 10.1503/cjs.005822. PMID: 37085291; PMCID: PMC10125160. [https://pubmed.ncbi.nlm.nih.gov/37085291/] Naren G, Guo J, Bai Q, Fan N, Nashun B. Reproductive and developmental toxicities of 5-fluorouracil in model organisms and humans. Expert Rev Mol Med. 2022 Jan 31;24:e9. doi: 10.1017/erm.2022.3. PMID: 35098910; PMCID: PMC9884763. [https://pubmed.ncbi.nlm.nih.gov/35098910/] National Comprehensive Cancer Network. (2026). NCCN Clinical Practice Guidelines in Oncology: Rectal Cancer (Version 2.2026). Retrieved from NCCN Guidelines for Rectal Cancer [https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1449] Oktay, Kutluk M.D., Ph.D.. Expert Commentary on Fertility Preservation in Colorectal Cancers: Current State and Practical Tips for the Cancer Practitioner. Diseases of the Colon & Rectum 63(6):p 726-727, June 2020. | DOI: 10.1097/DCR.0000000000001688 [https://pubmed.ncbi.nlm.nih.gov/32479532/] Stal J, YI SY, Cohen-Cutler S, et al. Fertility Preservation Discussions Between Young Adult Rectal Cancer Survivors and Their Providers: Sex-Specific Prevalence and Correlates. Oncologist. 2022;27(7):579-586. doi:10.1093/oncolo/oyac052 [https://pubmed.ncbi.nlm.nih.gov/35708892/] Gentile G, Ciccarone M. Management of fertility preservation in young female patients with gastrointestinal cancer: A case series and systematic literature review. Curr Probl Cancer. 2025;57:101221. doi:10.1016/j.currproblcancer.2025.101221 [https://pubmed.ncbi.nlm.nih.gov/39598263/] Saif MW. Management of colorectal cancer in pregnancy: a multimodality approach. Clin Colorectal Cancer. 2005;5(4):247-256. doi:10.3816/ccc.2005.n.035 [https://pubmed.ncbi.nlm.nih.gov/16183863/] Rogers JE, Dasari A, Eng C. The Treatment of Colorectal Cancer During Pregnancy: Cytotoxic Chemotherapy and Targeted Therapy Challenges. Oncologist. 2016 May;21(5):563-70. doi: 10.1634/theoncologist.2015-0362. Epub 2016 Mar 21. PMID: 27000464; PMCID: PMC4861360. [https://pubmed.ncbi.nlm.nih.gov/27000464/] Jiang Q, Hua H. Fertility in young-onset colorectal patients with cancer: a review. Oncologist. 2024;29(10):e1237-e1245. doi:10.1093/oncolo/oyae141 [https://pubmed.ncbi.nlm.nih.gov/39292850/] Dolmans MM, Hollanders de Ouderaen S, Demylle D, Pirard C. Utilization rates and results of long-term embryo cryopreservation before gonadotoxic treatment. J Assist Reprod Genet. 2015;32(8):1233-1237. doi:10.1007/s10815-015-0533-z [https://pubmed.ncbi.nlm.nih.gov/26162569/ Moawad NS, Santamaria E, Rhoton-Vlasak A, Lightsey JL. Laparoscopic Ovarian Transposition Before Pelvic Cancer Treatment: Ovarian Function and Fertility Preservation. J Minim Invasive Gynecol. 2017;24(1):28-35. doi:10.1016/j.jmig.2016.08.831 [https://pubmed.ncbi.nlm.nih.gov/27599763/] Fish R. Ovarian transposition in rectal cancer: uncertain benefit at a high price. Colorectal Dis. 2022;24(6):706-707. doi:10.1111/codi.16086 [https://pubmed.ncbi.nlm.nih.gov/35191146/] Ribeiro R, Baiocchi G, Moretti-Marques R, Linhares JC, Costa CN, Pareja R. Uterine transposition for fertility and ovarian function preservation after radiotherapy. Int J Gynecol Cancer. 2023;33(12):1837-1842. Published 2023 Dec 4. doi:10.1136/ijgc-2023-004723 [https://pubmed.ncbi.nlm.nih.gov/38104863/] Haggar F, Pereira G, Preen D, et al. Maternal and neonatal outcomes in pregnancies following colorectal cancer. Surg Endosc. 2013;27(7):2327-2336. doi:10.1007/s00464-012-2774-6 [https://pubmed.ncbi.nlm.nih.gov/23645367/] Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.  If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listenBehind the Knife Premium: https://behindtheknife.org/premiumOral Board Review: https://behindtheknife.org/oral-boardOral Board Simulator: https://behindtheknife.org/oral-board/simulatorGeneral Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-reviewTrauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlasDominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkshipDominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotationVascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-reviewColorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-reviewSurgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-reviewCardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-reviewDownload our App:Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US

In this episode of PICU Doc on Call, hosts Dr. Monica Gray and Dr. Pradip Kamat explore procedural sedation in the pediatric ICU. They cover sedation levels, pre-screening, risk stratification using ASA classifications, and medication selection tailored to each patient's hemodynamic and respiratory status. Through real-world case discussions involving respiratory failure, septic shock, and acute neurological decline, they highlight the importance of end-tidal CO2 monitoring and early adverse event recognition. Key takeaways include avoiding the term "conscious sedation," preparing rescue plans, and prioritizing patient safety through careful assessment and monitoring.Show Highlights:Definitions and levels of sedation (minimal, moderate, deep sedation, and general anesthesia)Importance of terminology in procedural sedationMonitoring sedation levels using scales like the Richmond Agitation-Sedation Scale (RASS)Pre-screening and risk stratification considerations for pediatric patientsASA physical status classification system for assessing patient riskUnique challenges of procedural sedation in critically ill childrenAdverse events associated with pediatric procedural sedation, particularly respiratory complicationsManagement strategies for specific cases requiring sedation (e.g., respiratory failure, septic shock)Importance of end-tidal CO2 monitoring during sedationKey takeaways for safe sedation practices in the pediatric ICU settingReferences: Nir Atlas; Rahul C. Damania; Pradip P. Kamat In Fuhrman & Zimmerman - Textbook of Pediatric Critical Care Chapter 135, 1624-1628Statement on Continuum of Depth of Sedation: Definition of General Anesthesia and Levels of Sedation/Analgesia by Committee on Quality Management and Departmental Administration. Last Amended: October 23, 2024.Coté CJ, Wilson S; AMERICAN ACADEMY OF PEDIATRICS; AMERICAN ACADEMY OF PEDIATRIC DENTISTRY. Guidelines for Monitoring and Management of Pediatric Patients Before, During, and After Sedation for Diagnostic and Therapeutic Procedures. Pediatrics. 2019 Jun;143(6):e20191000. doi: 10.1542/peds.2019-1000. PMID: 31138666.xKrauss B, Green SM. Procedural sedation and analgesia in children. Lancet. 2006 Mar 4;367(9512):766-80. doi: 10.1016/S0140-6736(06)68230-5. PMID: 16517277.Sharif S, Kang J, Sadeghirad B, Rizvi F, Forestell B, Greer A, Hewitt M, Fernando SM, Mehta S, Eltorki M, Siemieniuk R, Duffett M, Bhatt M, Burry L, Perry JJ, Petrosoniak A, Pandharipande P, Welsford M, Rochwerg B. Pharmacological agents for procedural sedation and analgesia in the emergency department and intensive care unit: a systematic review and network meta-analysis of randomised trials. Br J Anaesth. 2024 Mar;132(3):491-506. doi: 10.1016/j.bja.2023.11.050. Epub 2024 Jan 6. PMID: 38185564.Smith, Heidi A. B. MD, MSCI (Chair)1,2; Besunder, James B. DO, FCCM3,4; Betters, Kristina A. MD1; Johnson, Peter N. PharmD, BCPS, BCPPS, FCCM, FPPA, FASHP5,6; Srinivasan, Vijay MBBS, MD, FCCM7,8; Stormorken, Anne MD9,10; Farrington, Elizabeth PharmD, FCCM11; Golianu, Brenda MD12,13; Godshall, Aaron J. MD14; Acinelli, Larkin CPNP-AC, ACHPN15; Almgren, Christina CPNP16; Bailey, Christine H. MD17; Boyd, Jenny M. MD18,19; Cisco, Michael J. MD20; Damian, Mihaela MD, MPH21,22; deAlmeida, Mary L. MD23,24; Fehr, James MD13,25; Fenton, Kimberly E. MD, FCCM14; Gilliland, Frances DNP, CPNP-AC/PC26,27; Grant, Mary Jo C. CPNP-AC, PhD, FAAN28; Howell, Joy MD29; Ruggles, Cassandra A. PharmD, BCCCP, BCPPS30; Simone, Shari DNP31,32; Su, Felice MD21,22; Sullivan, Janice E. MD33,34; Tegtmeyer, Ken MD, FAAP, FCCM35,36; Traube, Chani MD, FCCM29; Williams, Stacey CPNP-AC37; Berkenbosch, John W. MD, FAAP, FCCM (Chair)33,34. 2022 Society of Critical Care Medicine Clinical Practice Guidelines on Prevention and Management of Pain, Agitation, Neuromuscular Blockade, and Delirium in Critically Ill Pediatric Patients With Consideration of the ICU Environment and Early Mobility. Pediatric Critical Care Medicine 23(2):p e74-e110, February 2022. | DOI: 10.1097/PCC.0000000000002873Benzoni T, Agarwal A, Cascella M. Procedural Sedation. [Updated 2025 Mar 22]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK551685/Kerson AG, DeMaria R, Mauer E, Joyce C, Gerber LM, Greenwald BM, Silver G, Traube C. Validity of the Richmond Agitation-Sedation Scale (RASS) in critically ill children. J Intensive Care. 2016 Oct 26;4:65. doi: 10.1186/s40560-016-0189-5. PMID: 27800163; PMCID: PMC5080705.Tel-Dan SF, Shavit D, Nates R, Samuel N, Shavit I. Emergency Physician-Administered Sedation for Thoracostomy in Children With Pleuropneumonia. Pediatr Emerg Care. 2021 Dec 1;37(12):e1209-e1212. doi: 10.1097/PEC.0000000000001975. PMID: 31929389.Cosgrove P, Krauss BS, Cravero JP, Fleegler EW. Predictors of Laryngospasm During 276,832 Episodes of Pediatric Procedural Sedation. Ann Emerg Med. 2022 Dec;80(6):485-496. doi: 10.1016/j.annemergmed.2022.05.002. Epub 2022 Jun 23. PMID: 35752522.Cravero JP, Blike GT, Beach M, Gallagher SM, Hertzog JH, Havidich JE, Gelman B; Pediatric Sedation Research Consortium. Incidence and nature of adverse events during pediatric sedation/anesthesia for procedures outside the operating room: report from the Pediatric Sedation Research Consortium. Pediatrics. 2006 Sep;118(3):1087-96. doi: 10.1542/peds.2006-0313. PMID: 16951002.

In dieser Vorlesung blende ich von der Ebene der satzwertigen Analyse auf Textebene, um Textprozeduren zu ermitteln und zu zeigen, wie und mit welchen sprachlichen Mitteln Erzählungen Räume öffnen und wie dies im Deutschunterricht genutzt werden kann. Anhand des authentischen Beispiels einer kindlichen Nacherzählung des Märchens "Schneewittchen" wird aufgezeigt, wie mittels temporaler und lokaler Adverbiale (Adverien und Präpositionalphrasen) Räumlichkeit und Figurenkonstellationen konstruiert und strukturiert werden können und der Verlauf einer Erzählung durch die Verkettung mentaler Räume gelingt, die im Beispiel als Orte, Areale und auch soziale Gemeinschaften durch Anordnung von Figuren zueinander in einer Geschichte zu beschreiben sind. Es wird am (authentischen) Beispiel demonstriert, wie Wortarten mithilfe generativer KI automatisiert ermittelt werden können, um interpretativ Adverbiale zu markieren. Darauf aufbauend werden computer- sowie korpuslinguistische Ansätze an Vergleichskorpora genutzt, um (inputoptimierte) sprachliche Mittel (z.B. Adverbien und adverial gebrauchte Präpostionalphrasen) für eine anschließende (prozedurorientierte) kreative Schreibphase der Schüler:innen zu identifizieren, die die Geschichte oder auch nur eine Szene adverbial erweitern.Präsentation (*.pdf): Alexander Lasch. 2026. Grammatik in der Schule. Zenodo. DOI: ⁠⁠⁠⁠https://doi.org/10.5281/zenodo.19236685⁠⁠⁠⁠. Videoaufzeichnungen: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://youtube.com/@AlexanderLasch⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Informationen & Material zu allen Vorlesungen: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://kurzelinks.de/fl7f⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Worksheet zu den Vorlesungen: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://kurzlinks.de/WorksheetVorlesungen⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Intro: "Reflections" von Scott Holmes (CC BY via ⁠⁠⁠⁠⁠⁠FMA⁠⁠⁠⁠⁠⁠).#Linguistik #OER #Sprache #Sprachwissenschaft #Grammatik #Konstruktionsgrammatik #Konstruktionsdikdatik

BUFFALO, NY – June 17, 2026 – A new #research paper was #published in Volume 17 of Oncotarget on June 8, 2026, titled “DHHC3 interferes with antitumor immunity in melanoma cells.” The study was led by first author and corresponding author Chandan Sharma and corresponding author Martin E. Hemler from the Department of Cancer Immunology and Virology at the Dana-Farber Cancer Institute. Melanoma is one of the most aggressive forms of skin cancer and is highly influenced by interactions between tumor cells and the immune system. Although modern immunotherapies have transformed treatment for many patients, researchers continue to search for molecular mechanisms that enable tumors to evade immune attack and continue growing. In this study, researchers investigated DHHC3, a protein acyltransferase that regulates protein palmitoylation and helps maintain cellular redox balance. Previous studies had linked elevated DHHC3 expression to poor outcomes in several cancers, but its role in melanoma and anti-tumor immunity remained unclear. To explore this question, the team used CRISPR gene editing to eliminate DHHC3 expression in B16F10 melanoma cells. Loss of DHHC3 caused a marked increase in oxidative stress and cellular senescence, as demonstrated by elevated TXNIP expression, increased reactive oxygen species levels, and enhanced expression of senescence-associated markers. Full press release - https://www.oncotarget.net/2026/06/17/protein-linked-to-melanoma-growth-may-suppress-the-bodys-natural-anti-tumor-immune-response/ DOI - https://doi.org/10.18632/oncotarget.28880 Correspondence to - Martin E. Hemler - martin_hemler@dfci.harvard.edu, and Chandan Sharma - csharma@mgh.harvard.edu Abstract video - https://www.youtube.com/watch?v=QQhP2VhzKSE Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28880 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, oxidative stress, DHHC3, anti-cancer immunity, palmitoylation, melanoma To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

In the library of a theological seminary, a researcher opens Eusebius's Church History and traces the bishops of Jerusalem - the mother church, the apostolic see of sees. He finds fifteen names spanning nearly two centuries. Marcus. Cassian. Publius. Maximus. Julian. Gaius. Symmachus. And eight more.No biographies. No letters. No sermons. No doctrines. No martyrdom accounts. Not a single quotation from their enemies. Fifteen bishops, two hundred years - and a perfect, surgical silence.Rome, Antioch, and Alexandria - churches that suffered the same persecutions - all preserved rich documentary traditions. Only Jerusalem is a vacuum. Not a damaged record. An erasure.This is Part 1 of "Sleight of Hand, Sleight of Scripture" - a documentary series from Pre-Nicene Perspective, hosted by Darren Kelama, based on the 2026 paper "The Myth of the Jerusalem Continuity" by Chancellor A.W. Mitchell (Journal of Pre-Nicene Christian Studies).In this episode, we walk the crime scene: Aelia Capitolina, the pagan colony Hadrian built on the rubble of Jerusalem in AD 135. Banned from the city on pain of death were not only Jews - but Jewish scriptures. Inside those walls, the only Christian canon that could legally exist was one without the Old Testament: the Evangelion and the Apostolikon. Hadrian, unwittingly, granted the unalloyed Pauline gospel a two-hundred-year sanctuary.And we meet the first ghost: Marcus, the first Gentile bishop of Aelia Capitolina, whom Mitchell identifies as the first Christian bishop in the Pauline sense - leader of a church whose Bible had no Torah, whose God was not Yahweh, whose throne was the mother church itself, and whose treasury held the accumulation of Paul's diaspora collection. ▶ PART 2 DROPS NEXT WEEK—————————⏱ CHAPTERS—————————0:00 — Cold Open: Fifteen Names, Fifteen Ghosts1:52 — The Question That Launched a 1,700-Year Cold Case2:20 — Welcome to Pre-Nicene Perspective (Series Intro)2:48 — Aelia Capitolina (AD 135)4:12 — Possessing the Septuagint Was a Capital Crime5:08 — The Only Christians Who Could Survive in Aelia6:04 — The Mitchell Thesis (2026 Paper)7:00 — Part III — The Red Herrings8:24 — Claim 1: "The Records Were Lost"9:48 — Claim 2: Irenaeus Never Quotes Them10:44 — Claim 3: "Jerusalem Was Always Yahwist"11:40 — Part IV — The Investigation Begins12:36 — The First Christian Bishop in the Pauline Sense13:04 — The Treasury of the Mother Church13:52 — The Apostolikon — Paul's War Report14:28 — Marcus Resolves to Act (Cliffhanger — Part 2 Next Week)—————————ACADEMIC SOURCES & FURTHER READING—————————

Prostate cancer is the most commonly diagnosed cancer among men and remains a leading cause of cancer-related death worldwide. While age, family history, and genetics are well-established risk factors, researchers have increasingly focused on the role of metabolic health in prostate cancer progression. Obesity, insulin resistance, type 2 diabetes, and chronic inflammation have all been associated with more aggressive disease, but the molecular mechanisms connecting these conditions to prostate cancer remain incompletely understood. A research paper titled “Epigenetic dysregulation and biological function of PDX1 in prostate cancer” was published in Volume 17 of Oncotarget. In this study, the researchers investigated whether a gene best known for regulating pancreatic function may also play an important role in prostate tumor biology. The study was led by first author Tayo A. Adeyika and corresponding author Bernard Kwabi-Addo from Howard University, Washington, DC. Full blog - https://www.oncotarget.org/2026/06/16/pdx1-may-link-metabolic-dysfunction-to-prostate-cancer-progression/ DOI - https://doi.org/10.18632/oncotarget.28854 Correspondence to - Bernard Kwabi-Addo - bkwabi-addo@howard.edu Abstract video - https://www.youtube.com/watch?v=itYVsyXJJoE Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28854 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, PDX1, DNA methylation prostate cancer, shRNA knockdown, over-expression, glucose To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

The early modern period was a rocky time for religion across Europe, fundamental pinnings of everyday life were being questioned and changing, as the reformation shifted authority away from the church. Thoughts on death and the afterlife were turned upside down, and in villages across England, restless spirits were making a comeback. To confront these supernatural intruders, communities turned to their local clergy to carry out the practice of ghost-laying, an exorcism ritual that sought to bind and banish the dead. At least, that's what Victorian authors would have liked to believe. Part religion, part folklore, and part fear, the subject of ghost-laying is fairly well complicated, and defining just how much of it is actually true, even more so. SOURCES Walsh, Brendan C. (2023) ‘He Could Raise and Lay Ghosts at His Will': Victorian Folklorists and the Creation of Early Modern Clerical Ghost-Laying. Folklore, 134:3, 281-303, DOI: 10.1080/0015587X.2023.2187157 Bottrell, William (1870) Traditions & Hearthside Stories of West Cornwall. Beare & Son, Penzance, UK. Hawker, Robert Steven (1870) Footprints of Former Men in Far Cornwall. James C. Commin, Exeter, UK. Andrews, William (1898) The Church Treasury of History, Custom, Folk-Lore, etc. London, UK. Bond, Thomas (1823) Topographical and Historical Sketches of the Boroughs of East and West Looe, in the County of Cornwall. J. Nichols & Son, London, UK. Hunt, Robert (1865) Popular Romances of the West of England, Or, The Drolls, Traditions and Superstitions of Old Cornwall. John Camden Hotten, London, UK. Courtney, Margaret Anne (1973) Cornish Feasts & Folklore. EP Publishing Ltd. UK. ------ For almost anything, head over to the podcasts hub at ⁠⁠⁠⁠⁠⁠⁠darkhistories.com ⁠⁠⁠⁠⁠⁠⁠ Support the show by visiting our Patreon for bonus episodes and Early Access: ⁠⁠⁠⁠⁠⁠⁠https://www.patreon.com/darkhistories⁠⁠⁠⁠⁠⁠⁠ The Dark Histories books are available to buy here: ⁠⁠⁠⁠⁠⁠⁠http://author.to/darkhistories⁠⁠⁠⁠⁠⁠⁠ Dark Histories merch is available here: ⁠⁠⁠⁠⁠⁠⁠https://bit.ly/3GChjk9⁠⁠⁠⁠⁠⁠⁠ Connect with us on Facebook: ⁠⁠⁠⁠⁠⁠⁠http://facebook.com/darkhistoriespodcast⁠⁠⁠⁠⁠⁠⁠ Or find us on Twitter: ⁠⁠⁠⁠⁠⁠⁠http://twitter.com/darkhistories⁠⁠⁠⁠⁠⁠⁠ & Instagram: ⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/dark_histories/⁠⁠⁠⁠⁠⁠⁠ Or you can contact us directly via email at ⁠⁠⁠⁠⁠⁠⁠contact@darkhistories.com⁠⁠⁠⁠⁠⁠⁠ or join our Discord community: ⁠⁠⁠⁠⁠⁠⁠https://discord.gg/cmGcBFf⁠⁠⁠⁠⁠⁠⁠ The Dark Histories Butterfly was drawn by Courtney, who you can find on Instagram @bewildereye Music was recorded by me © Ben Cutmore 2017 Other Outro music was Paul Whiteman & his orchestra with Mildred Bailey - All of me (1931). It's out of copyright now, but if you're interested, that was that. Learn more about your ad choices. Visit megaphone.fm/adchoices

BUFFALO, NY – June 15, 2026 – A new #research paper was #published in Volume 17 of Oncotarget on June 5, 2026, titled “A randomized double-blind placebo-controlled phase I/II clinical trial of a human papillomavirus therapeutic vaccine, PepCan, for reducing head and neck squamous cell carcinoma recurrence.” The study was led by first author Emily Bivens and corresponding author Mayumi Nakagawa from the University of Arkansas for Medical Sciences, Little Rock. Head and neck squamous cell carcinoma (HNSCC) remains a major clinical challenge. Even after surgery, radiation, and chemotherapy successfully eliminate detectable disease, many patients experience recurrence within the following years. Researchers have therefore been exploring whether immunotherapy-based approaches can help strengthen anti-tumor immune responses and reduce the risk of cancer returning. In this study, investigators evaluated PepCan, an experimental therapeutic vaccine designed to stimulate immune responses against human papillomavirus type 16 (HPV 16). Unlike preventive HPV vaccines that aim to stop infection before it occurs, therapeutic vaccines are intended to activate the immune system against existing HPV-related disease. PepCan contains four HPV 16 E6 peptides combined with a Candida-derived immune-stimulating adjuvant. Full press release - https://www.oncotarget.net/2026/06/15/hpv-therapeutic-vaccine-shows-safety-but-uncertain-benefit-in-preventing-head-and-neck-cancer-recurrence/ DOI - https://doi.org/10.18632/oncotarget.28892 Correspondence to - Mayumi Nakagawa - mnakagawa@uams.edu Abstract video - https://www.youtube.com/watch?v=oh0MNrrPGhw Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28892 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, human papillomavirus, head and neck cancer, therapeutic vaccine, adjuvant, clinical trial To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us on social media: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

This week we go back 2.5 years and delve into the world of cardiovascular surgery when we review a review of STS data on the pulmonary artery band (PAB). The STS assigns a STAT category of 4 to this operation, denoting higher risk for mortality. Is this warranted? Are all PAB candidates equal? What features are associated with higher or lower mortality rates in patients undergoing banding? Should the data in this work drive innovation to avoid the PAB in some settings? These are amongst the questions posed to the senior author of this week's work, cardiovascular surgeon Dr. Tara Karamlou who is Professor of Surgery at the Cleveland Clinic in Cleveland, Ohio. DOI: 10.1016/j.athoracsur.2023.09.020

If you enjoy this episode, we're sure you will enjoy more content like this on The Occult Rejects.  In fact, we have curated playlists on occult topics like grimoires, esoteric concepts and phenomena, occult history, analyzing true crime and cults with an occult lens, Para politics, and occultism in music. Whether you enjoy consuming your content visually or via audio, we've got you covered - and it will always be provided free of charge.  So, if you enjoy what we do and want to support our work of providing accessible, free content on various platforms, please consider making a donation to the links provided below.  Thank you and enjoy the episode!Links For The Occult Rejectshttps://linktr.ee/theoccultrejectsOccult Research Institutehttps://www.occultresearchinstitute.org/Substackhttps://substack.com/@theoccultrejects?r=7auau0&utm_campaign=profile&utm_medium=profile-pageCash Apphttps://cash.app/$theoccultrejectsVenmo@TheOccultRejectsBuy Me A Coffeebuymeacoffee.com/TheOccultRejectsPatreonhttps://www.patreon.com/TheOccultRejectsBibliographyAelian. On the Characteristics of Animals. Translated by A. F. Scholfield. Loeb Classical Library. Cambridge, MA: Harvard University Press, 1958–1959.Assmann, Jan. The Search for God in Ancient Egypt. Translated by David Lorton. Ithaca: Cornell University Press, 2001.British Museum. “Papyrus of Nesmin; Bremner-Rhind Papyrus, EA10188.” Notes that the Book of Overthrowing Apep appears in columns 22–32, with the Names of Apep in columns 32–33, and gives a production date of 305 BCE.British Museum. Babylon Teachers' Resource. Notes Marduk's association with the snake-dragon or mušḫuššu.Burkert, Walter. Greek Religion. Translated by John Raffan. Cambridge, MA: Harvard University Press, 1985.Day, John. God's Conflict with the Dragon and the Sea: Echoes of a Canaanite Myth in the Old Testament. Cambridge: Cambridge University Press, 1985.Detroit Institute of Arts. “Mushhushshu-Dragon, Symbol of the God Marduk.”Eliade, Mircea. Patterns in Comparative Religion. Translated by Rosemary Sheed. Lincoln: University of Nebraska Press, 1996.Etymonline. “Draco.” Notes Greek drakon from derkesthai, “to see clearly.”Faulkner, R. O. “The Bremner-Rhind Papyrus—III: D. The Book of Overthrowing ‘Apep.” Journal of Egyptian Archaeology 23, no. 2 (1937): 166–185.Ferdowsi. Shahnameh: The Persian Book of Kings. Translated by Dick Davis. New York: Penguin Classics, 2016.Herodotus. The Histories. Translated by A. D. Godley. Loeb Classical Library. Cambridge, MA: Harvard University Press, 1920. See especially 2.75 on winged serpents and ibises, and 3.107 on frankincense-guarding serpents.Hornung, Erik. Conceptions of God in Ancient Egypt: The One and the Many. Translated by John Baines. Ithaca: Cornell University Press, 1982.Isbell, Lynne A. The Fruit, the Tree, and the Serpent: Why We See So Well. Cambridge, MA: Harvard University Press, 2009.Jacobus de Voragine. The Golden Legend: Readings on the Saints. Translated by William Granger Ryan. Princeton: Princeton University Press, 2012.Jones, David E. An Instinct for Dragons. New York: Routledge, 2000.Le, Quan Van, Lynne A. Isbell, Jumpei Matsumoto, Minh Nguyen, Hikari Hori, Mai Mai, Tomohiro Nishimaru, et al. “Pulvinar Neurons Reveal Neurobiological Evidence of Past Selection for Rapid Detection of Snakes.” Proceedings of the National Academy of Sciences 110, no. 47 (2013): 19000–19005. DOI: 10.1073/pnas.1312648110.LeDoux, Joseph. The Emotional Brain: The Mysterious Underpinnings of Emotional Life. New York: Simon & Schuster, 1996.Lincoln, Bruce. Theorizing Myth: Narrative, Ideology, and Scholarship. Chicago: University of Chicago Press, 1999.MacLean, Paul D. The Triune Brain in Evolution: Role in Paleocerebral Functions. New York: Plenum Press, 1990.Mayor, Adrienne. The First Fossil Hunters: Dinosaurs, Mammoths, and Myth in Greek and Roman Times. Princeton: Princeton University Press, 2000; revised edition, 2011.Öhman, Arne, and Susan Mineka. “Fears, Phobias, and Preparedness: Toward an Evolved Module of Fear and Fear Learning.” Psychological Review 108, no. 3 (2001): 483–522.Pessoa, Luiz. The Cognitive-Emotional Brain: From Interactions to Integration. Cambridge, MA: MIT Press, 2013.Pliny the Elder. Natural History. Translated by H. Rackham. Loeb Classical Library. Cambridge, MA: Harvard University Press, 1938–1962.Smith, Mark S. The Ugaritic Baal Cycle. 2 vols. Leiden: Brill, 1994–2009.Smith, Mark S. The Origins of Biblical Monotheism: Israel's Polytheistic Background and the Ugaritic Texts. Oxford: Oxford University Press, 2001.Varenne, Jean, trans. The Rig Veda. New York: Park Street Press, 1984.Yarshater, Ehsan, ed. “Aždahā.” Encyclopaedia Iranica. Defines aždahā as dragon-like, gigantic snake monsters found in air, earth, or sea, sometimes linked to rain and eclipses.Also want to remind people about the website, if you're into reading we have tons of information by multiple contributors, and we got t-shirts up on the site if you're interested. Fun fact, the art is all based on the eyeball. A

Join the Behind the Knife Surgical Oncology Team as we discuss clinical challenges through case-based examples including the diagnosis, workup, and management of patients with cutaneous melanoma. Learning Objectives:In this episode, we review the workup and management of patients with cutaneous melanoma and both microscopic and macroscopic nodal disease. References used in the making of this episode: Reijers, I.L.M., Menzies, A.M., van Akkooi, A.C.J. et al. Personalized response-directed surgery and adjuvant therapy after neoadjuvant ipilimumab and nivolumab in high-risk stage III melanoma: the PRADO trial. Nat Med 28, 1178–1188 (2022). https://doi.org/10.1038/s41591-022-01851-x Christian U. Blank et al. Neoadjuvant nivolumab plus ipilimumab versus adjuvant nivolumab in macroscopic, resectable stage III melanoma: The phase 3 NADINA trial.. J Clin Oncol 42, LBA2-LBA2(2024). DOI:10.1200/JCO.2024.42.17_suppl.LBA2 Faries MB, Thompson JF, Cochran AJ, et al. Completion Dissection or Observation for Sentinel-Node Metastasis in Melanoma. N Engl J Med. 2017;376(23):2211-2222. doi:10.1056/NEJMoa1613210   https://pubmed.ncbi.nlm.nih.gov/28591523/ National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Cutaneous Melanoma. Version 1.2026. Accessed April 8, 2026. NCCN Guidelines PDF   Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.  If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listenBehind the Knife Premium: https://behindtheknife.org/premiumOral Board Review: https://behindtheknife.org/oral-boardOral Board Simulator: https://behindtheknife.org/oral-board/simulatorGeneral Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-reviewTrauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlasDominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkshipDominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotationVascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-reviewColorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-reviewSurgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-reviewCardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-reviewDownload our App:Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US

In the ACOG PB 231, Multifetal Gestations Twin Triplet and Higher-Order Multifetal Pregnancies, it states, “based on the improved outcomes reported in singleton gestations, the National Institutes of Health recommends that, unless a contraindication exists, a course of antenatal corticosteroids should be administered to all patients who are at risk of delivery within 7 days and who are between 24 weeks and 34 weeks of gestation, irrespective of the fetal number”. But a BRAND NEW meta-analysis is saying the exact opposite- with a catch. Listen in for details.1. ACOG PB 2312. Felippe, Carolina Alves MS; Ruiz, Sinrraim dos Santos Chaves MD; de Souza, Rebeca Ferreira MS; de Lima, Aliny Silva MS; dos Santos, Priscila Luiza MS; Fonseca, Pandora Eloa Oliveira MS; de Almeida Silva, Ingryd MS; Montes-de-Oca-Saucedo, Carlos Roberto MD; Santana, Ana Cecília Oliveira MS; Veta Darkovski, Jasmina MD; Matlaw, Hadas Rachel MD; Fonseca Queiroz, Laura MD. Antenatal Corticosteroid Use in Twin Pregnancies: A Systematic Review and Meta-analysis. Obstetrics & Gynecology ():10.1097/AOG.0000000000006344, June 4, 2026. | DOI: 10.1097/AOG.000000000000634416% OFF TONA ACTIVE WEAR PROMO: https://tonaactive.com/discount/CHAPANOSPINOBG

Carlos Juan Finlay was a Cuban doctor who did a lot of work to understand the spread of Yellow Fever. But Walter Reed got most of the credit. Research: American Experience. “Carlos Finlay (1833-1915).” From The Great Fever. PBS. https://www.pbs.org/wgbh/americanexperience/features/fever-carlos-finlay/ Berenbrok, Dorothy E., "Latin Heritage Month. Carlos Juan Finlay: Outrageous, Courageous and Correct" (2015). Posters: Jefferson History. 3. https://jdc.jefferson.edu/jeffhistoryposters/3 "Carlos Juan Finlay." Encyclopedia of World Biography Online, Gale, 1998. Gale In Context: Opposing Viewpoints, link.gale.com/apps/doc/K1631002194/GPS?u=mlin_n_melpub&sid=bookmark-GPS&xid=bfeecc25. Accessed 29 Apr. 2026. Chaves-Carballo, Enrique. “Carlos J. Finlay: The mosquito man.” Hektoen International. 11/2/2020. https://hekint.org/2020/11/02/carlos-j-finlay-the-mosquito-man/ Corbitt, Duvon C. “Carlos J. Finlay, Cuban Physician.” The Hispanic American Historical Review, Vol. 45, No. 3 (Aug., 1965). Via JSTOR. https://www.jstor.org/stable/2511751 Del Regato, Juan A. “Carlos Juan Finlay (1833-1915).” Journal of Public Health Policy , 2001, Vol. 22, No. 1 (2001). Via JSTOR. https://www.jstor.org/stable/3343556 Faerstein, Eduardoa; Winkelstein, Warren Jrb. Carlos Juan Finlay: Rejected, Respected, and Right. Epidemiology 21(1):p 158, January 2010. | DOI: 10.1097/EDE.0b013e3181c308e0 Ferreira Moreno, Víctor Guillermo. “Evocation to the Dr. Carlos J. Finlay Barres on the centennial of his death.” Colombia medica (Cali, Colombia) vol. 47,1 63-6. 30 Mar. 2016 Finlay, Carlos J. “The Mosquito Hypothetically Considered as the Agent of Transmission of Yellow Fever.” Read before the Royal Academy of Medical, Physical and Natural Sciences Session of August 14th, 1881. https://archive.org/details/b33448541/page/590/mode/1up Finlay, Carlos Juan. “Trabajos selectos del Dr. Carlos J. Finlay. Selected papers of Dr. Carlos J. Finlay.” Habana. 1912. https://archive.org/details/trabajosselectos00finl Finlay, Charles. “Inoculations for Yellow Fever by Means of Contaminated Mosquitoes.” Published in The American Journal of the Medical Sciences, n.s. 102: 264-268, 1891. https://archive.org/details/b33445242/page/n4/mode/1up Finlay, Charles. “Yellow Fever: Its ‘Transmission by Means of the Culex Mosquito.” Published in The American Journal of the Medical Sciences, n.s. 92: 395-409, 1886. https://archive.org/details/b33435698/page/613/mode/1up Palmer, Steven. “A Cuban Scientist Between Empires: Peripheral Vision on Race and Tropical Medicine.” Canadian Journal of Latin American and Caribbean Studies / Revue canadienne desétudes latino-américaines et caraïbes, Vol. 35, No. 69, Special Issue: Landscapes of LatinAmerican Health, 1870-1970. Via JSTOR. https://www.jstor.org/stable/41800498 Spears, Ellen Griffith and Rosa López-Oceguera. “Carlos Juan Finlay, William Gorgas, and Walter Reed and the U.S. Army Yellow Fever Controversy: Competing Historical Memories.” Alabama Review The University of Alabama Press. Volume 74, Number 1, January 2021. https://doi.org/10.1353/ala.2021.0011 Stepan, Nancy. “The Interplay between Socio-Economic Factors and Medical Science: Yellow Fever Research, Cuba and the United States.” Social Studies of Science , Nov., 1978, Vol. 8, No. 4 (Nov., 1978). Via JSTOR. http://www.jstor.com/stable/284817 Thomas Jefferson University. “10 Notable Jefferson Alumni of the Past.” https://library.jefferson.edu/archives/exhibits/notable_alumni/juan_carlos_finlay.cfm Tone, John Lawrence. (2002) “How the mosquito (man) liberated Cuba.” History and Technology, 18:4, 277-308, DOI: 10.1080/07341512.2002.11417735 “Carlos J. Finlay.” 5/16/2023. https://www.unesco.org/en/prizes/carlos-j-finlay/about Woodall, Jack. "Yellow Fever." Infectious Diseases: In Context, edited by Brenda Wilmoth Lerner and K. Lee Lerner, vol. 2, Gale, 2008, pp. 925-931. In Context Series. Gale In Context: Opposing Viewpoints, link.gale.com/apps/doc/CX3045200265/GPS?u=mlin_n_melpub&sid=bookmark-GPS&xid=bf646a26. Accessed 29 Apr. 2026. See omnystudio.com/listener for privacy information.

United States v. Bhagat Singh Thind was a 1923 case that hinged on what it meant to be white. Research: “Ozawa v. United States, 260 U.S. 178 (1922).” https://supreme.justia.com/cases/federal/us/260/178/ “United States v. Bhagat Singh Thind, 261 U.S. 204 (1923).” https://supreme.justia.com/cases/federal/us/261/204/ de la Garza, Amanda. “Doctorji: The Life. Teachings, and Legacy of Dr. Bhagat Singh Thind.” David Bhagat Thind. 2010. Deslippe, Philip. “Bhagat Singh Thind in Jail.” SAADA. https://www.saada.org/tides/article/bhagat-singh-thind-in-jail Deslippe, Philip. “Doctorji the Divorcé: Understanding Bhagat Singh Thind Through His Marriage to Inez Buelen.” Ethnic Studies Review 1 July 2023; 46 (1-2): 52–68. doi: https://doi.org/10.1525/esr.2023.46.1-2.52 Kanwar, Joy. “Stories from the Negative Spaces: United States v. Thind and the Narrative of (Non)Whiteness.” Mercer Law Review. Vol. 74, No. 3. 2023. https://digitalcommons.law.mercer.edu/cgi/viewcontent.cgi?article=3111&context=jour_mlr Munshi, Sherally. “Remembering Thind.” Ethnic Studies Review, Vol. 46, Issue 1-2, pp. 98–116. DOI: https://doi.org/10.1525/esr.2023.46.1-2.98 Ogden, Johanna. “The Telling Case of Doctor Bhagat Singh Thind.” Oregon Historical Quarterly. Vol. 124, No. 1. 2023. https://www.ohs.org/oregon-historical-quarterly/back-issues/upload/Ogden_Baghat-Singh-Thind_OHQ-124_1_Spring-2023_web.pdf “Bhagat Singh Thind.” Roots in the Sand. 2000. https://www.pbs.org/rootsinthesand/i_bhagat1.html Pillai, Daksha. “United States v. Bhagat Singh Thind: Dual Legacies of a Forgotten Supreme Court Case.” Gilder Lehrman Institute of American History. https://www.gilderlehrman.org/sites/default/files/file_media/38_Pillai.pdf Qin, Amy. “In the Birthright Citizenship Hearing, a Story of Asians Fighting for Rights.” New York Times. 4/2/2026. https://www.nytimes.com/2026/04/02/us/politics/birthright-citizenship-asian-immigrants.html Shankar, Arjun. “On Brown Blood Race, Caste, and the Bhagat Singh Thind Case.” Ethnic Studies Review, Vol. 46, Issue 1-2, pp. 135–155. DOI: https://doi.org/10.1525/esr.2023.46.1-2.135 Smith, Marian L. “Race, Nationality, and Reality: INS Administration of Racial Provisions in U.S. Immigration and Nationality Law Since 1898.” Prologue. Vol. 34, No. 2. Summer 2002. https://www.archives.gov/publications/prologue/2002/summer/immigration-law-1 South Asian American Digital Archive. “The Problem.” https://www.saada.org/explore/exhibits/theproblem Supreme Court of the United States. “Donald J. Trump, president of the United States et al., petitioners, v. Barbara et al, Respondents.” No. 25-365. Oral arguments. Heritage Reporting Corporation. April 1, 2026. https://www.supremecourt.gov/oral_arguments/argument_transcripts/2025/25-365_l6gn.pdf The Pluralism Project. “The Ghadar Party: Freedom for India.” Harvard University. https://pluralism.org/the-ghadar-party-freedom-for-india See omnystudio.com/listener for privacy information.