Podcasts about DOI

This week we speak with Ohio State ACHD fellow Andrew Freddo MD, PhD about a recent large single center study he conducted assessing the cardiovascular drugs that adult Fontan patients are taking and whether they might offer us insights into general well-being. Are there agents that are associated with worse outcomes? If so, is this a situation of the agent causing harm or is it a possible marker of illness? Are there agents associated with improved outcomes? These are amongst the questions reviewed with Dr. Freddo this week. DOI: 10.1016/j.jacadv.2025.102070

No episódio 93 do Fronteiras no Tempo, Marcelo Beraba e o Estagiário Rodolfo recebem dois convidados de peso para uma conversa que atravessa décadas de disputas políticas, econômicas e culturais: a professora Camila Feix Vidal (Economia e Relações Internacionais – UFSC) e o professor Marcos Sorrilha (História – UNESP). Juntos, eles exploram a Influência dos Estados Unidos na América Latina, analisando como o poder norte-americano moldou governos, economias, culturas e até imaginários sociais em nosso continente. Da Doutrina Monroe à Guerra Fria, das intervenções militares à dependência econômica, o episódio mergulha nas múltiplas camadas dessa relação complexa – marcada tanto por alianças estratégicas quanto por tensões profundas. Se você quer entender como o "quintal americano" se transformou em um campo de disputas globais e como essas dinâmicas ainda ecoam no presente, este episódio é indispensável. Dá o play e vem com a gente atravessar as fronteiras da história e da geopolítica! Artes do Episódio: C. A. Mencionado no Episódio YOUTUBE (Canal do Sorrilha). Qual é o correto: Americano ou estadunidense? YouTube, 2023. Disponível em: https://www.youtube.com/watch?v=KWKktKCj2Qc A IDADE DOURADA (The Gilded Age). Criação de Julian Fellowes. [Série de televisão]. Estados Unidos: HBO, 2022–. Disponível em: https://www.imdb.com/pt/title/tt4406178/ GREJO, Camila Bueno. Entre a diplomacia e a História: a atuação de Estanislao Zeballos frente ao Panamericanismo. Revista de Historia de América, n. 165, p. 165–191, maio-ago. 2023. ISSN impresso: 0034-8325. ISSN eletrônico: 2663-371X. DOI: https://doi.org/10.35424/rha.165.2023.1106 INSTITUTO DE ESTUDOS LATINO-AMERICANOS (IELA – UFSC). Página institucional. Florianópolis: Universidade Federal de Santa Catarina, [s.d.]. Disponível em: https://iela.ufsc.br/instituto/?ancora=#colaboradores . Acesso em: 4 nov. 2025. INSTITUTO DE ESTUDOS LATINO-AMERICANOS (IELA – UFSC). Canal no YouTube. Florianópolis: Universidade Federal de Santa Catarina, [s.d.]. Disponível em: https://www.youtube.com/@Ielaufsc . Acesso em: 4 nov. 2025. Financiamento Coletivo Existem duas formas de nos apoiar Pix recorrente – chave: fronteirasnotempo@gmail.com Apoia-se – https://apoia.se/fronteirasnotempo Redes Sociais Twitter, Facebook, Youtube, Instagram Contato fronteirasnotempo@gmail.com Material Complementar ANDREWS, George Reide. América Afro-Latina (1800-2000). trad. Magda Lopes. São Carlos: EDUFSCAR, 2007 DULCI, Tereza Maria Spyer. As conferências Pan-Americanas (1889 a 1928): identidades, união aduaneira e arbitragem. São Paulo: Alameda Casa Editorial, 2013. FITZ, Caitlin Annette. Our Sister Republics: The United States in an Age of American Revolutions. New York: W.W. Norton & Company, 2016. PECEQUILO, Cristina Soreanu. A política externa dos Estados Unidos. 3. ed. ampliada e atualizada. Porto Alegre: Editora UFRGS, 2011. SCHOULTS, Lars. Estados Unidos: poder e submissão – uma história da política norte-americana em relação à América Latina. Trad. Raul Fiker. Bauru-SP: EDUSC, 2000. Como citar esse episódio Fronteiras no Tempo #93 Influência dos EUA na América Latina. Locução Marcelo de Souza Silva, Rodolfo Grande Neto, Camila Felix Vidal, Marcos Sorrilha, Willian Spengler e Cesar Agenor Fernandes da Silva [S.l.] Portal Deviante, 06/11/2025. Podcast. Disponível em: https://www.deviante.com.br/?p=66000&preview=true Expediente Produção Geral: C. A. e Beraba. Hosts: Marcelo Beraba e Estagiário Rodolfo. Recordar é viver: Willian Spengler. Artes do Episódio: C. A. Edição: Talk’nCast Madrinhas e Padrinhos Apoios a partir de 12 de junho de 2024 Alexsandro de Souza Junior, Aline Silva Lima, André Santos, André Trapani, Andréa Gomes da Silva, Andressa Marcelino Cardoso, Augusto Carvalho, Carolina Pereira Lyon, Charles Calisto Souza, Edimilson Borges, Elisnei Menezes de Oliveira, Erick Marlon Fernandes da Silva, Flávio Henrique Dias Saldanha, Gislaine Colman, Iara Grisi, João Ariedi, Klaus Henrique de Oliveira, Manuel Macias, Marlon Fernandes da Silva, Pedro Júnior Coelho da Silva Nunes, Rafael Henrique Silva, Raul Sousa Silva Junior, Renata de Souza Silva, Ricardo Orosco, Rodrigo Mello Campos, Rubens Lima e Willian Spengler See omnystudio.com/listener for privacy information.

Today, Jenny and Mr. John dig into some new research and more real talk yet again! From optimal resistance training or results to ultraprocessed foods and putting an end to type 1 diabetes, the research is coming in hot! And don;t miss John's Real Talk about education in the fitness fields- it comes in many shapes and ways! Happy listening!References: 1. Comparable Strength and Hypertrophic Adaptations to Low-Load and High-Load Resistance Exercise Training in Trained Individuals: Many Roads Lead to RomeKristoffer Toldnes Cumming, Ingrid Cecelia Elvatun, Richard Kalenius, Gordan Divljak, Truls Raastad, Niklas Psilander, Oscar Horwath bioRxiv 2025.04.28.650925; doi: https://doi.org/10.1101/2025.04.28.6509252. Samuel J. Dicken, Friedrich C. Jassil, Adrian Brown, Monika Kalis, Chloe Stanley, Chaniqua Ranson, Tapiwa Ruwona, Sulmaaz Qamar, Caroline Buck, Ritwika Mallik, Nausheen Hamid, Jonathan M. Bird, Alanna Brown, Benjamin Norton, Claudia A. M. Gandini Wheeler-Kingshott, Mark Hamer, Chris van Tulleken, Kevin D. Hall, Abigail Fisher, Janine Makaronidis, Rachel L. Batterham. Ultraprocessed or minimally processed diets following healthy dietary guidelines on weight and cardiometabolic health: a randomized, crossover trial. Nature Medicine, 2025; DOI: 10.1038/s41591-025-03842-03. Mayo Clinic. "This sugar molecule could stop type 1 diabetes, by fooling the immune system." ScienceDaily. www.sciencedaily.com/releases/2025/08/250802022917.htm (accessed August 2, 2025).

Welcome to this episode of Mind the Kids, the podcast from the Association for Child and Adolescent Mental Health. In an episode titled 'Income(ing): Poverty and Resilience' Dr. Jane Gilmour and Professor Umar Toseeb are joined by Dr. Divyangana Rakesh from King's College London, to discuss her groundbreaking research on cognitive resilience among children growing up in poverty. The discussion centers on the paper 'Beyond the Income Achievement Gap: The Role of Individual, Family, and Environmental Factors in Cognitive Resilience Among Low-Income Youth' published in JCPP Advances. You can access the full article via DOI: 10.1002/jcv2.12297. Dr. Rakesh shares insights into how some children manage to thrive cognitively despite economic hardship. As she explains, “Although growing up in poverty carries many risks, some children defy the odds and demonstrate positive cognitive outcomes. Identifying factors that promote such resilience in disadvantaged contexts is essential for informing interventions and policies.” She highlights the crucial role of family, community, and individual factors that can foster resilience and improve educational outcomes. Join us as we explore the complex interplay of these factors and what they mean for child mental health and societal action. This episode is essential listening for anyone invested in understanding and supporting young people's development in disadvantaged contexts. Don't forget to like, subscribe, and share with your networks.

BUFFALO, NY — November 5, 2025 — A new #research paper was #published in Volume 17, Issue 10 of Aging-US on September 10, 2025, titled “Longitudinal associations of epigenetic aging with cognitive aging in Hispanic/Latino adults from the Hispanic Community Health Study/Study of Latinos.” In this study led by Myriam Fornage, from The University of Texas Health Science Center at Houston, researchers found that faster biological aging, measured by DNA-based epigenetic clocks, is associated with greater cognitive decline and higher risk of mild cognitive impairment (MCI) in Hispanic/Latino adults. The results highlight the potential of epigenetic clocks to track changes in brain health over time, helping improve early detection and monitoring of age-related cognitive problems. Cognitive decline and dementia are major public health concerns, especially among aging populations. In this study, researchers followed 2671 Hispanic/Latino adults (average age 57; 66% women) over a seven-year period. They measured each participant's biological age using epigenetic clocks and assessed their cognitive performance at two time points. “We evaluated the associations of 5 epigenetic clocks and their between-visit change with multiple measures of cognitive aging that included a global and domain-specific cognitive function score at each visit, between-visit change in global and domain-specific cognitive function score, and MCI diagnosis at visit 2 (V2).” Epigenetic clocks estimate biological age based on DNA chemical modifications, called methylation, that accumulate with age. The study evaluated five different clocks, including newer models like GrimAge and DunedinPACE, which are designed to more accurately reflect health-related aging. The researchers found that individuals with faster biological aging showed lower cognitive function and higher probability of developing MCI over time. Among the five clocks studied, newer models such as GrimAge and DunedinPACE showed the strongest associations with memory, processing speed, and overall brain health. These findings suggest that tracking changes in biological age over time may be more effective than relying on a single measurement to identify those at risk for cognitive impairment. Importantly, the associations between biological aging and cognitive decline remained significant even after accounting for other known risk factors such as education, language preference, and cardiovascular health. This supports the idea that epigenetic clocks capture unique biological processes that influence brain aging. The study also found that the impact of changes in biological age over time was comparable to that of APOE4, a well-established genetic risk factor for Alzheimer's disease. Overall, this is the first large-scale study to examine these associations in a Hispanic/Latino population, a group that is underrepresented in aging research. By identifying early biological signs of brain aging, this work highlights the potential of epigenetic clocks as tools for routine health assessments. Monitoring changes in these biological markers could help detect individuals at risk for cognitive decline and guide timely interventions to preserve brain health. DOI - https://doi.org/10.18632/aging.206317 Corresponding author - Myriam Fornage - Myriam.Fornage@uth.tmc.edu Abstract video - https://www.youtube.com/watch?v=kG0Y-F_sods To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@Aging-US LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Se libérer de nos fantômes coloniaux Enfant, Malek, réalisateur algérien exilé en France, allait à Boufarik, en Algérie, pour manger des oranges. Il y croisait la statue d'un soldat en armes, juchée sur son piédestal à plus de 7 mètres 50 de haut. C'était la statue du sergent Blandan, héros de la conquête coloniale de l'Algérie, érigée à Boufarik à la fin du XIXème siècle et "rapatriée" en France, à Nancy. C'est là que par hasard, un matin neigeux de 1990, Malek a retrouvé le fantôme de son enfance. Le refoulé colonial a soudain ressurgi. Il a raconté sa rencontre effrayante à sa fille, qui à son tour décide de partir sur les traces de ce fantôme, en France et en Algérie. Mais à mesure qu'elle s'approche de lui, elle est à son tour hantée. Comment se libérer du fantôme colonial qui fait corps avec la statue du sergent Blandan, héros de la conquête de l'Algérie ?Avec :Malek Kellou, Susana Gállego Cuesta, Kenza-Marie Safraoui, Don Quichotte, habitants de NancyBibliographie :Gilbert Meynier, « L'Algérie et les Algériens sous le système colonial. Approche historico historiographique», Insaniyat / إنسانيات [En ligne], 65-66 | 2014. URL : http://journals.openedition.org/insaniyat/14758 ; DOI : https://doi.org/10.4000/insaniyat.14758Pour aller plus loin :- Karima Lazali, Le Trauma colonial : une enquête sur les effets psychiques et politiques contemporains de l'oppression coloniale en Algérie, Paris, La Découverte, 2018 ; - Alain Ruscio, La première guerre d'Algérie. Une histoire de conquête et de résistance, 1830-1852, Paris, La Découverte, 2024 ; - Benjamin Stora, La gangrène et l'oubli. La mémoire de la guerre d'Algérie, Paris, La Découverte, 1991 ; - Dorothée-Myriam Kellou, Nancy-Kabylie, Paris, Grasset, 2023.Remerciements :Malek Kellou, Susana Gállego Cuesta, Kenza-Marie Safraoui, le Musée des Beaux-Arts de Nancy, Etienne Augris, Bachir Ahdouga, Don Quichotte, Perrine Kervran, Mathilde Guermonprez, Mathieu Nicol. Prise de son, entretien et montage Dorothée-Myriam Kellou Enregistrements octobre-novembre 2024 Réalisation et mixage Annabelle Brouard Chanson "La casquette du père Bugeaud", chant militaire de l'Armée d'Afrique écrit en 1846 Illustration Pierre Place Production ARTE Radio

BUFFALO, NY — November 3, 2025 — A new #research paper featured on the #cover of Volume 17, Issue 10 of Aging-US was #published on October 20, 2025, titled “Brain region-specific and systemic transcriptomic alterations in a human alpha-synuclein overexpressing rat model.” In this study, led by first author Vivien Hoof and corresponding author Thomas Hentrich from Saarland University, Germany, researchers investigated how excess alpha-synuclein—a protein linked to Parkinson's disease—affects gene activity in different brain regions and the gut. They found that early, region-specific gene disruptions may contribute to the appearance of disease, with some effects also detected in the gut. These early molecular changes could serve as biomarkers for Parkinson's and point to new directions for treatment. Alpha-synuclein accumulates in the brains of individuals with Parkinson's disease and other age-related neurological conditions known as synucleinopathies. To better understand this process, the research team used a genetically modified rat model that overexpresses human alpha-synuclein. They studied gene expression in the striatum, cortex, and cerebellum—three key brain regions involved in movement and cognition—and analyzed how these changes evolved with age. “Transcriptomic analyses were performed on gene and transcript level of striatal, frontocortical, and cerebellar tissue in 5- and 12-month-old transgenic (BAC SNCA) and wild type rats […]” The results showed that gene alterations appeared earlier and were more pronounced in young rats, particularly in the striatum and cortex, before any visible signs of disease manifested. This early disruption challenges the common belief that gene alterations gradually increase with age and suggests that early-life molecular changes may be critical in disease development. The researchers also found that many gene expression changes were unique to individual brain regions. However, they identified a set of genes that were consistently affected across all brain regions and the gut. This suggests that the disease may begin to affect the entire body—not just the brain—long before symptoms become noticeable. Several of the shared genes are involved in synaptic signaling and inflammation—processes known to be altered in Parkinson's. Others are linked to dopamine production and neuronal plasticity, indicating potential early efforts by the brain to compensate for the harmful effects of the alpha-synuclein buildup. Overall, this study provides a detailed view of how alpha-synuclein affects gene networks early in the disease process. Understanding these changes may help identify biomarkers and develop targeted therapies before irreversible brain damage occurs. DOI - https://doi.org/10.18632/aging.206331 Corresponding author - Thomas Hentrich - thomas.hentrich@uni-saarland.de Abstract video - https://www.youtube.com/watch?v=Yl6AfVchkb0 Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206331 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, alpha-synuclein, transgenic rat model, different brain regions, transcriptome analysis To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@Aging-US LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Taking folic acid prior to conception and during pregnancy can help protect the unborn baby from developing abnormalities. Supplements are particularly important for women who have epilepsy, as anti-seizure medication (previously known as anti-convulsants or anti-epileptic drugs) can lead to a deficiency in folic acid. Until 2023, high doses of 4-5 mg per day were recommended. However, this has changed as the data has changed. Did you know the SMFM no longer recommends “high dose” folic acid preconceptionally for patients on seizure medications? This is also highlighted in a recently released epub from Obstetrics and Gynecology (Green Journal) on October 31, 2025. Listen in for details. 1. Mokashi, Mugdha MD, MPH; Cozzi-Glaser, Gabriella MD; Kominiarek, Michelle A. MD, MS. Dietary Supplements in the Perinatal Period. Obstetrics & Gynecology ():10.1097/AOG.0000000000006098, October 31, 2025. | DOI: 10.1097/AOG.00000000000060982. Asadi-Pooya AA. High dose folic acid supplementation in women with epilepsy: are we sure it is safe? Seizure. 2015 Apr;27:51-3. doi: 10.1016/j.seizure.2015.02.030. Epub 2015 Mar 7. PMID: 25891927.3. https://aesnet.org/about/aes-press-room/press-releases/guideline-issued-for-people-with-epilepsy-who-may-become-pregnant4. Turner C, McIntosh T, Gaffney D, Germaine M, Hogan J, O'Higgins A. A 10-year review of periconceptual folic acid supplementation in women with epilepsy taking antiseizure medications. J Matern Fetal Neonatal Med. 2025 Dec;38(1):2524094. doi: 10.1080/14767058.2025.2524094. Epub 2025 Jun 30. PMID: 40588438.5. https://www.aan.com/PressRoom/Home/PressRelease/5170#:~:text=The%20guideline%20recommends%20that%20people,and%20possibly%20improve%20neurodevelopmental%20outcomes.6. https://aesnet.org/about/aes-press-room/press-releases/guideline-issued-for-people-with-epilepsy-who-may-become-pregnant

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A growing number of patients with stubborn IBS symptoms are asking: if the gut and brain are wired together, could changing one transform the other? In this episode, we sit down with Dr. Emeran Mayer and Dr. Erin Mauney to explore what the emerging field of psychedelic-assisted therapy could mean for gut-brain health, beyond the headlines and hype. In this episode we cover:Why traditional IBS treatments often fall short.How psilocybin opens a neuroplastic “window” for processing pain, stress, and interoception.The therapeutic process: preparation, guided dosing, and integration.Early study results: symptom relief, reduced visceral sensitivity, and improved self-illness separation.Safety, variability, and practical questions about access and candidacy.If you're curious about neuroplasticity, the brain-gut axis, psilocybin, and the future of IBS care, this episode offers a grounded, hopeful, and responsible guide to what's known, and what's next. This episode is sponsored by GI Psychology. References: Psychedelic-assisted therapy: An overview for the internistBarnett BS, Mauney EE, King F 4th. Psychedelic-assisted therapy: An overview for the internist. Cleve Clin J Med. 2025;92(3):171-180. Published 2025 Mar 3. doi:10.3949/ccjm.92a.24032Psychedelic-assisted Therapy as a Promising Treatment for Irritable Bowel SyndromeMauney, Erin MD*; King, Franklin IV MD†; Burton-Murray, Helen PhD‡; Kuo, Braden MD‡. Psychedelic-assisted Therapy as a Promising Treatment for Irritable Bowel Syndrome. Journal of Clinical Gastroenterology 59(5):p 385-392, May/June 2025. | DOI: 10.1097/MCG.0000000000002149 Psilocybin and IBS treatment: First psychedelic study in gastroenterologyLearn more about the MGH study with Dr. Erin Mauney and colleagues here.Learn more about Kate and Dr. Riehl:Website: www.katescarlata.com and www.drriehl.comInstagram: @katescarlata @drriehl and @theguthealthpodcastOrder Kate and Dr. Riehl's book, Mind Your Gut: The Science-Based, Whole-body Guide to Living Well with IBS. The information included in this podcast is not a substitute for professional medical advice, examination, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider before starting any new treatment or making changes to existing treatment.

Shaurya Taran, MD, joins CHEST® Journal Podcast Moderator Alice Gallo De Moraes, MD, FCCP, to discuss his research into the association between low-tidal-volume ventilation and mortality in patients with acute brain injuries receiving mechanical ventilation.   DOI: 10.1016/j.chest.2025.06.042 Disclaimer: The purpose of this activity is to expand the reach of CHEST content through awareness, critique, and discussion. All articles have undergone peer review for methodologic rigor and audience relevance. Any views asserted are those of the speakers and are not endorsed by CHEST. Listeners should be aware that speakers' opinions may vary and are advised to read the full corresponding journal article(s) for complete context. This content should not be used as a basis for medical advice or treatment, nor should it substitute the judgment used by clinicians in the practice of evidence-based medicine. 

Stephanie C. DeMasi, MD, joins CHEST® Journal Podcast Moderator, Matt Siuba, DO, MS, to discuss her research comparing neurologic outcomes between lower and higher oxygen saturation targets following cardiac arrest.  DOI: 10.1016/j.chest.2025.04.027 Disclaimer: The purpose of this activity is to expand the reach of CHEST content through awareness, critique, and discussion. All articles have undergone peer review for methodologic rigor and audience relevance. Any views asserted are those of the speakers and are not endorsed by CHEST. Listeners should be aware that speakers' opinions may vary and are advised to read the full corresponding journal article(s) for complete context. This content should not be used as a basis for medical advice or treatment, nor should it substitute the judgment used by clinicians in the practice of evidence-based medicine. 

Katarina Zeder, MD, PhD, joins CHEST® Journal Podcast Moderator Matt Siuba, DO, MS, to discuss her research into the ways in which longitudinal pulmonary arterial pressure trajectories inform clinical outcome in patients undergoing kidney transplantation.  DOI: 10.1016/j.chest.2025.05.024 Disclaimer: The purpose of this activity is to expand the reach of CHEST content through awareness, critique, and discussion. All articles have undergone peer review for methodologic rigor and audience relevance. Any views asserted are those of the speakers and are not endorsed by CHEST. Listeners should be aware that speakers' opinions may vary and are advised to read the full corresponding journal article(s) for complete context. This content should not be used as a basis for medical advice or treatment, nor should it substitute the judgment used by clinicians in the practice of evidence-based medicine. 

Eva-Maria Schmolke, MD, and Kathrin Knochel, MD, join CHEST® Journal Podcast Moderator Matt Siuba, DO, MS, to discuss their research into the institutional implementation of a national triage guideline in German ICUs during the initial phases of the COVID-19 pandemic and their subsequent analysis of widespread covert triage as a response to legal uncertainty around triage guidelines.   DOI: 10.1016/j.chest.2025.05.044 Disclaimer: The purpose of this activity is to expand the reach of CHEST content through awareness, critique, and discussion. All articles have undergone peer review for methodologic rigor and audience relevance. Any views asserted are those of the speakers and are not endorsed by CHEST. Listeners should be aware that speakers' opinions may vary and are advised to read the full corresponding journal article(s) for complete context. This content should not be used as a basis for medical advice or treatment, nor should it substitute the judgment used by clinicians in the practice of evidence-based medicine. 

 What's the episode about? In this episode, hear Dr Jessica Young on assisteddying, the New Zealand End of Life Choice Bill, culturally responsive research, end of life care and decision making, and sociological approaches.Who is Jessica?Dr Jessica Young is a Senior Research Fellow at Victoria University of Wellington and the University of Auckland, and an adjunct senior lecturer in the Australian Centre for Health Law Research, Queensland University of Technology.She is a sociologist specialising in death, dying andassisted dying. She completed her PhD in 2020 at the University of Otago and received a prestigious post-doctoral fellowship from the Cancer Society of New Zealand.Since the End of Life Choice Bill was introduced in NewZealand, Dr Young has been building a programme of research to investigate multiple facets of assisted dying.  She leads and contributes to several projects on assisteddying, most recently ‘Exploring the early experiences of the assisted dying service in Aotearoa', funded by the Health Research Council. Dr Young has led impactful research in end-of-life care, securing over $3 million in competitive funding.  She is the founder and co-chair of New Zealand'sAssisted Dying Research Network and was appointed by the Director-General of Health to the Support and Consultation for End of Life in NZ (SCENZ) Group (2021–2023). Her work has directly shaped national policy: 13 of her team's recommendations were adopted in the Ministry of Health's 2024 End of Life Choice Act Review.She has published over 40 peer-reviewed articles, six editorials, and three book chapters.  To ensure her research goes beyond academia, she activelyengages with media. She is passionate about improving end-of-life experiences for patients, whānau/families and health practitioners. Committed to ethical, inclusive, and culturally responsive research, she seeks to involve tangatawhenua (indigenous people of NZ), stakeholders and communities. You can find Jessica on LinkedIn https://www.linkedin.com/in/jessica-young-7097a722/ The book introduced in the episode introduction is Death, Commemoration, and Cultural Meaning Past and PresentEdited by Robert Spinelli and Robyn S. Lacy. How do I cite the episode in my research and reading lists?To cite this episode, you can use thefollowing citation: Young, J. (2025) Interview on The Death Studies Podcast hosted by Michael-Fox, B. and Visser, R. Published 1 November 2025. Available at: www.thedeathstudiespodcast.com, DOI: 10.6084/m9.figshare.30507878 What next?Check out more episodes or find out more about the hosts! Gota question? Get in touch.

Back on August 9, 2024, we released an episode (link in the show notes) reviewing the renewed interest in transfusing whole blood for PPH rather than component therapy. Now, in O&G open, authors from my Alma Mater (UT Southwestern) have published new data bolstering the use of whole blood for PPH. Listen in for details.1. Clinical Pearls Episode 2024: https://open.spotify.com/episode/0ZhqoIE9wMcAboDlevq9OW?si=rM32uK8ER8uuWmq4mf5dzA2. Ambia, Anne M. MD; Burns, R. Nicholas MD; White, Alesha MD; Warncke, Kristen MD; Gorman, April MS; Duryea, Elaine MD; Nelson, David B. MD. Whole Blood in the Management of Postpartum Hemorrhage. O&G Open 2(5):e130, October 2025. | DOI: 10.1097/og9.00000000000001303. ACPG PB 183STRONG COFFEE PROMO: 20% Off Strong Coffee Company https://strongcoffeecompany.com/discount/CHAPANOSPINOBG

This week we review the results of the new pivotal trial of the 'Minima' stent by Renata Medical. What is special about this new device that makes it particularly desirable for use in small children? How strong is cobalt chromium and what evidence exists that it can be expanded repeatedly over 1-2 decades? Can this technology supplant surgery for certain diseases such as native coarctation? What are the limitations of this device? We speak with the first author of the pivotal trial, Dr. Patrick Sullivan of CHLA who is Associate Professor of Pediatrics at Keck Medicine at USC. DOI: 10.1161/CIRCINTERVENTIONS.125.015618

Feeling knee pain on the bike (or in life)? You're not alone, and it doesn't have to be your norm. In this episode of Making Shift Happen, Jen breaks down why knees hurt (even when your bike fit is fine), why isometric strength training (like wall-sits) is a powerful tool, and how supporting hips and ankles will give your knees the backup they deserve. You'll learn: Why knee pain shows up for cyclists and what real causes are (it's not just your saddle height) How isometric wall-sits and other iso exercises reduce knee/tendon pain and build resilience (evidence included) How to structure your off-season strength and mobility plan for pain-free knees next season Why the upcoming #ShredStrong program (starts Nov 3rd - details below!) is the best way to build the strength system your knees demand Check out these other relevant episodes: This episode also includes the link for the free PDF on bike fit: 219. MTB Gains: Strength Training Secrets with a PT Who Rides  155. Combining Bike Fit and Physical Therapy with Natalie Colins, DPT Research referenced in this episode: PMID 31033611  DOI: 10.2147/OAJSM.S136653 #ShredStrong: Our Fall Cycle Starts on Monday, November 3, 2025! #ShredStrong is my year-round strength training program for mountain bikers and gravel cyclists. You can join any time you want, but we're starting the main Fall cycle in November! Learn more about the program and sign-up HERE!  Do You Want a Coach to Help Make Training & Nutrition Easier and Simpler for You? Hi, it's me.

In this episode of the Epigenetics Podcast, we talked with Vincent Pasque from KU Leuven about his work on the reprogramming of cell identity through epigenetic mechanisms, particularly during early development and cellular reprogramming. We begin by tracing Vincent's journey into biology, sparked by early childhood experiences in nature and meaningful encounters with inspiring teachers. His fascination with the complexities of biology crystallized during a pivotal moment while listening to a radio segment on epigenetics in the late '90s, which led him to pursue studies in genetics and biochemistry. This formative path brought him to leading institutions, including the prestigious lab of John Gurdon, where he explored the phenomenon of nuclear reprogramming. Vincent recounts his early experiments that led to the discovery of macro H2A as a barrier to reprogramming, emphasizing the core challenge of erasing somatic cell identity. As the conversation unfolds, Vincent introduces us to critical findings from his research. He shares how the inactive X chromosome serves as a compelling model to investigate epigenetic regulation, revealing that the dynamics of reprogramming and differentiation are far from simple reversals of development. He highlights the significant differences between male and female iPSCs and how X-linked genes influence DNA methylation and differentiation rates in these cells. The implications of these findings extend beyond developmental biology to inform our understanding of diseases, particularly cancer. Transitioning to his current work, Vincent describes pioneering advances in characterizing the chromatin-associated proteome during the differentiation of human pluripotent stem cells. The surprising discovery of elevated histone modifications in naïve cells leads to intriguing questions about the barriers to cellular plasticity and the mechanisms by which cells resist alternative fate conversions. The potential applications of this research could reshape our approach to regenerative medicine and therapeutic interventions. References Pasque V, Gillich A, Garrett N, Gurdon JB. Histone variant macroH2A confers resistance to nuclear reprogramming. The EMBO Journal. 2011 May;30(12):2373-2387. DOI: 10.1038/emboj.2011.144. PMID: 21552206; PMCID: PMC3116279. Jullien, J., Miyamoto, K., Pasque, V., Allen, G. E., Bradshaw, C. R., Garrett, N. J., Halley-Stott, R. P., Kimura, H., Ohsumi, K., & Gurdon, J. B. (2014). Hierarchical Molecular Events Driven by Oocyte-Specific Factors Lead to Rapid and Extensive Reprogramming. Molecular Cell, 55(4), 524–536. https://doi.org/10.1016/j.molcel.2014.06.024 Pasque V, Tchieu J, Karnik R, et al. X chromosome reactivation dynamics reveal stages of reprogramming to pluripotency. Cell. 2014 Dec;159(7):1681-1697. DOI: 10.1016/j.cell.2014.11.040. PMID: 25525883; PMCID: PMC4282187. Zijlmans DW, Talon I, Verhelst S, et al. Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction. Nature Cell Biology. 2022 Jun;24(6):858-871. DOI: 10.1038/s41556-022-00932-w. PMID: 35697783; PMCID: PMC9203278. Related Episodes The Discovery of Genomic Imprinting (Azim Surani) Gene Expression Control and Intricacies of X-chromosome Inactivation (Claire Rougeulle) Epigenetics and X-Inactivation (Edith Heard) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

Elinzanetant, sold under the brand name Lynkuet, receivedapproval from the U.S. Food and Drug Administration (FDA) on October 24, 2025, for the treatment of moderate to severe hot flashes due to menopause.  How is this different than Fezolinetant, which was approved in 2023? Listen in for details. 1.   Menegaz de Almeida, Artur MS; Oliveira, Paloma MS; Lopes, Lucca MD; Leite, Marianna MS; Morbach, Victória MS; Alves Kelly, Francinny MD; Barros, Ítalo MS; Aquino de Moraes, Francisco Cezar MS; Prevedello, Alexandra MD. Fezolinetant and Elinzanetant Therapy for Menopausal Women Experiencing Vasomotor Symptoms: A Systematic Review and Meta-analysis. Obstetrics & Gynecology 145(3):p 253-261, March 2025. | DOI: 10.1097/AOG.00000000000058122.     Pinkerton JV, Simon JA, Joffe H, Maki PM, NappiRE, Panay N, Soares CN, Thurston RC, Caetano C, Haberland C, Haseli Mashhadi N, Krahn U, Mellinger U, Parke S, Seitz C, Zuurman L. Elinzanetant for the Treatment of Vasomotor Symptoms Associated With Menopause: OASIS 1 and 2 Randomized Clinical Trials. JAMA. 2024 Aug 22;332(16):1343–54. doi: 10.1001/jama.2024.14618. Epub ahead of print. PMID: 39172446; PMCID: PMC11342219.3.     Cardoso F, Parke S, Brennan DJ, Briggs P,Donders G, Panay N, Haseli-Mashhadi N, Block M, Caetano C, Francuski M, Haberland C, Laapas K, Seitz C, Zuurman L. Elinzanetant for Vasomotor Symptomsfrom Endocrine Therapy for Breast Cancer. N Engl J Med. 2025 Aug 21;393(8):753-763. doi: 10.1056/NEJMoa2415566. Epub 2025 Jun 2. PMID: 40454634.STRONG COFFEE PROMO: 20% Off Strong CoffeeCompany https://strongcoffeecompany.com/discount/CHAPANOSPINOBG

This podcast discusses human flourishing in PE. The discussion revolves around Jamie Brunsdon's recent papers on this topic, and I've invited some colleagues for a discussion around this topic that was committed to by all parties at the AIESEP conference in 2025 after a great discussion. The star of the show is Dr. Jamie Brunsdon who is at University of Memphis. Also on the podcast are Obi Atkinson from SUNY Cortland, and Seunghyun Baek also from SUNY Cortland. here are the citations of the two papers we discussed:Jamie Jacob Brunsdon (24 Sep 2024): Human Flourishing as the Aim of Physical Education?, Quest, DOI: 10.1080/00336297.2024.2402710 Brunsdon, J. J. (2024). Toward the virtuous mover: A neo-Aristotelian interpretation of physical education. Physical Education and Sport Pedagogy, 29(6), 588–600. https://doi.org/10.1080/17408989.2022.2135693

בפרק הזה נדבר על המלחמה השקטה שאנשים מנהלים עם הגוף שלהם, מלחמה שהורסת להם את הסיכוי להצליח עם התזונה בטווח הארוך. נדבר גם על הרגע שבו הגוף מפסיק “להרוס” ומתחיל להגן, ועל הדרך שבה אפשר להפוך אותו ממתנגד עקשן לשותף חכם בתהליך. נבין מהי הקשבה חדשה לגמרי לגוף *מבפנים*, איך אכילה רגשית הופכת לשפה שבה הגוף מבקש קשר, ואיך אפשר ללמוד סוף סוף לתרגם את השפה הזו: מרעב לשובע, ממתח לשקט, מביקורת לסקרנות. זה לא עוד פרק על כוח רצון, זו הזמנה לגלות את כוח-החיבור  לאינטלגנציה המדהימה של הגוף, שמכניסה דרך החדשה לרדת מהמלחמה באוכל, מבלי לאבד את עצמך בדרך.   חינם: מדריך מקיף איך להפסיק עם הנשנושים בערב: https://rutifink.vp4.me/night לפרטים על טיפולים אצלינו: https://rutifink.vp4.me/ebge   עקבו אחריי לעוד המון מידע חינמי: אינסטגרם: https://www.instagram.com/rutifink/ טיק-טוק: https://www.tiktok.com/@rutifink פייסבוק: https://www.facebook.com/fink.ruti יוטיוב: https://www.youtube.com/@rutifink לקבלת מייל בכל פעם שיוצא פרק חדש של הפודקאסט: http://rutifink.vp4.me/podcast   רפרנסים: DOI: 10.1038/s41366-021-00950-y DOI: 10.1016/j.physbeh.2021.113434 DOI: 10.1016/j.eatbeh.2014.06.002 DOI: 10.1016/j.appet.2024.107343 DOI: 10.1111/jhn.13176 DOI: 10.1177/1359105317697813 DOI: 10.1016/j.appet.2017.10.013 DOI: 10.1016/j.appet.2025.108143 DOI: 10.1016/j.appet.2016.09.011

On January 18, 2020, we released an episode called “Vaginal Vit C for BV? Yep, it's DATA”. That was 5 years ago! Now, in the Green Journal, a new systematic review and meta-analysis is examining this subject….AGAIN. Plus, this is not the only systematic review to investigate this; a similar review was published in Acta Obstétrica e Ginecológica Portuguesa earlier this year (2025) in March. So, did we get it right 5 years ago? Can vaginal Vit C help in eliminating BV? Listen in for details!1. Khaikin, Yannay MD; Elangainesan, Praniya MD, MSc; Winkler, Eliot MD, MSc; Liu, Kuan PhD, MMath; Selk, Amanda MD, MSc; Yudin, Mark H. MD, MSc. Intravaginal Vitamin C for the Treatment and Prevention of Bacterial Vaginosis: A Systematic Review and Meta-analysis. Obstetrics & Gynecology ():10.1097/AOG.0000000000006092, October 23, 2025. | DOI: 10.1097/AOG.0000000000006092; https://journals.lww.com/greenjournal/pages/articleviewer.aspx?year=9900&issue=00000&article=01389&type=Fulltext2. Acta Obstétrica e Ginecológica Portuguesa (March 2025): chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://scielo.pt/pdf/aogp/v19n1/1646-5830-aogp-19-01-40.pdf3. Chapa Clinical pearls 2020: https://podcasts.apple.com/gh/podcast/vaginal-vit-c-for-bv-yep-its-data/id1412385746?i=1000463002444

BUFFALO, NY — October 27, 2025 — A new #research paper was #published in Volume 17, Issue 9 of Aging-US on September 17, 2025, titled “Depletion of the TRF1 telomere-binding protein leads to leaner mice with altered metabolic profiles.” In this study led by first author Jessica Louzame Ruano and corresponding author Maria A. Blasco from the Spanish National Cancer Centre (CNIO), researchers investigated the role of TRF1, a protein known for protecting telomeres, in regulating whole-body metabolism. The results suggest that TRF1 influences metabolic health through mechanisms unrelated to its known function in telomere maintenance. Obesity and metabolic disorders are major health concerns, especially as people age. To explore TRF1's role beyond telomere protection, the research team studied both normal mice and genetically modified mice that lacked TRF1. Mice without TRF1 remained leaner over time, resisted fat accumulation, and showed healthier blood sugar and insulin levels compared to normal mice. Importantly, these benefits occurred without any detectable shortening of telomeres. The leaner body composition in TRF1-deficient mice was not due to reduced food intake or increased physical activity. Instead, the fat loss appeared to result from biological changes in how energy was processed and stored. Male mice without TRF1 gained less weight and had lower LDL cholesterol levels, even on a high-fat diet. Female mice showed milder effects, reflecting known sex-based differences in susceptibility to diet-induced obesity. This highlights the importance of including both sexes in metabolic research. “Major metabolic pathways related with energy production and regulation of metabolism homeostasis were also found downregulated in Trf1-deficient mice.” Gene expression analysis in the liver revealed shifts in several key pathways. Genes related to fat production, energy generation, and muscle growth were downregulated, while genes linked to inflammation and cholesterol synthesis were upregulated. The mice also showed signs of higher energy expenditure and a shift from using fat to protein as an energy source, possibly due to their reduced fat reserves. However, some older mice developed mild liver stress, including fibrosis and DNA damage, suggesting a possible long-term trade-off. Overall, this study expands the understanding of how telomere-related proteins influence more than just cellular aging. By identifying a connection between TRF1 and metabolism, the research opens new possibilities for targeting TRF1 or its pathways to address obesity and related conditions. Still, further studies are needed to clarify how TRF1 affects fat development and whether similar effects occur in humans. DOI - https://doi.org/10.18632/aging.206320 Corresponding author - Maria A. Blasco — mblasco@cnio.es Abstract video - https://www.youtube.com/watch?v=7AG3TBgDZIw Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206320 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, Trf1, metabolism, leaner, fat, telomeres To learn more about the journal, visit https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Hair Loss in Women” (The New England Journal of Medicine 2025; DOI 10.1056/NEJMcp2412146) 

BUFFALO, NY — October 23, 2025 — A new #research paper was #published in Volume 17, Issue 9 of Aging-US on September 11, 2025, titled “Roles of plasminogen activator inhibitor-1 in aging-related muscle and bone loss in mice.” In this study led by first author Takashi Ohira and corresponding author Hiroshi Kaji from Kindai University Faculty of Medicine, researchers found that female mice lacking the gene for plasminogen activator inhibitor-1 (PAI-1) were protected from age-related muscle weakness and bone thinning. This suggests that PAI-1 could be a potential target for future treatments to reduce frailty in aging populations. As the global population continues to age, more people are affected by conditions such as sarcopenia and osteoporosis. These disorders involve the progressive loss of skeletal muscle mass and bone density, leading to reduced mobility, a greater risk of falls, and a lower quality of life. To investigate the role of PAI-1 in aging, researchers compared young (6-month-old) and aged (24-month-old) male and female mice, with and without the PAI-1 gene. They found that PAI-1 levels increased with age in both sexes. However, only female mice lacking the PAI-1 gene experienced a significant reduction in age-related muscle and bone loss. Female mice without PAI-1 maintained stronger grip strength and greater muscle mass in their lower limbs. They also showed less cortical bone loss in their femurs and tibias. In contrast, male mice did not experience the same benefits, despite also showing increased levels of PAI-1 with age. These results suggest that PAI-1 contributes to aging-related decline in a sex-specific manner. “The present study found that lower limb muscle mass, gastrocnemius and soleus muscle tissue weights, and grip strength were significantly lower in 24-month-old male and female wild-type mice than in their 6-month-old counterparts.” PAI-1 plays key roles in blood clotting, inflammation, and cellular senescence—a process in which aging cells release harmful molecules that affect nearby tissues. One of these molecules, interleukin-6 (IL-6), is a major driver of inflammation. The researchers found that aged female mice lacking PAI-1 had lower IL-6 levels in both muscle and blood, suggesting that PAI-1 may contribute to muscle and bone loss by promoting inflammation. These protective effects were also not associated with changes in muscle protein turnover or reductions in fibrous tissue, reinforcing the idea that PAI-1's impact is likely driven by inflammatory signaling. This study highlights PAI-1 as a promising therapeutic target for slowing or preventing age-related declines in muscle and bone health, particularly in women. Since postmenopausal women are especially vulnerable to osteoporosis and frailty, a better understanding of how PAI-1 contributes to aging could lead to new strategies for maintaining strength and mobility in later life. Further research is needed to explore how PAI-1 interacts with other age-related biological changes and why its effects differ between sexes. DOI - https://doi.org/10.18632/aging.206318 Corresponding author - Hiroshi Kaji - hkaji@med.kindai.ac.jp Abstract video - https://www.youtube.com/watch?v=hg4qKf-oO2I Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@Aging-US LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

ASOPRS Website: Click Here Have you ever wanted to know more about aesthetic lasers, but don't know where to start?  Confused by the lingo? Join Dr. Nicole Langelier as she takes Dr. Christina Choe and Dr. Sandy Zhang-Nunes through a whirlwind tour of laser physics, laser terminology, and laser-tissue interactions. We'll explain how lasers work, discuss selective photothermolysis, cover basic skin anatomy, and define workhorse terms like chromophore, wavelength, joules, watts, fluence, thermal relaxation time, and pulse width. Consider this the prequel to upcoming episodes on the clinical uses of ablative laser resurfacing, non-ablative laser resurfacing, light and energy based devices.  By understanding the language and core scientific concepts of lasers, we hope to make you a safer and more educated laser provider!   Corrections/Clarifications: - Blood vessels are lined by endothelium (not epithelium) - The skin registers pain from heat at 45C, but may occur between 43-44C with variability based on the time of exposure and area of exposure (I stated it occurs at 42C) https://www.cardinalhealth.com/content/dam/corp/web/documents/whitepaper/cardinal-health-localized-temperature-therapy%20White%20Paper.pdf - The exact number varies by source, but waters absorbs the erbium 2940nm wavelength 10-20 times more efficiently than it absorbs the CO2 10,600nm wavelength (I said 30 times) - Clarification:  Eyelid skin is thinner closer to the lashes and on the medial aspect of the eyelid as compared to skin further from the lashes and the lateral aspect of the eyelid.  A study in Korean skin by Hwang et al found the thickest part of the eyelid to be just below the eyebrow (1.127 +/- 238um) with the thinnest skin near the ciliary margin 320 +/- 49um).  Jeong et al found that epidermal thickness is similar between genders while men had thicker reticular dermis than women and skin thickness was not correlated with BMI. - The UV wavelengths range from 100nm - 400nm.  UVC: 100nm - 280nm; UVB: 280nm-315nm; UVA: 315-400.  (I used single wavelength numbers rather than a range for ease of explanation).   Citations for skin thickness: Full thickness punch biopsies from cadaver heads processed with paraffin-embedded slides: Karan Chopra, Daniel Calva, Michael Sosin, Kashyap Komarraju Tadisina, Abhishake Banda, Carla De La Cruz, Muhammad R. Chaudhry, Teklu Legesse, Cinithia B. Drachenberg, Paul N. Manson, Michael R. Christy, A Comprehensive Examination of Topographic Thickness of Skin in the Human Face, Aesthetic Surgery Journal, Volume 35, Issue 8, November/December 2015, Pages 1007–1013, https://doi.org/10.1093/asj/sjv079   Ultrasonographic measurements in live participants: Jeong KM, Seo JY, Kim A, Kim YC, Baek YS, Oh CH, Jeon J. Ultrasonographic analysis of facial skin thickness in relation to age, site, sex, and body mass index. Skin Res Technol. 2023 Aug;29(8):e13426. doi: 10.1111/srt.13426. PMID: 37632182; PMCID: PMC10370326.   Cut and trichrome stained specimens from fresh cadavers Hwang, Kun MD, PhD*; Kim, Dae Joong PhD†; Hwang, Se Ho†. Thickness of Korean Upper Eyelid Skin at Different Levels. Journal of Craniofacial Surgery 17(1):p 54-56, January 2006. | DOI: 10.1097/01.scs.0000188347.06365.a0  

Prüfungsstress, Blackout, Panik? Student Jens kennt das gut, und er ist damit nicht allein. Doch es gibt Tipps, die wirklich helfen, ruhig und selbstbewusst durch die Klausurenphase zu kommen. Und last minute hilft Power Posing.**********Ihr hört: Autor und Host: Przemek Żuk Gesprächspartner: Jens, hat Prüfungsangst Gesprächspartnerin: Klara Sommer, psychologische Psychotherapeutin, forscht an der Humboldt-Universität Berlin zu Prüfungsangst Gesprächspartnerin: Beatrix Stark, Psychologin und systemische Therapeutin, psychosoziale Beraterin für die Uni Leipzig und HTWK Leipzig Redaktion: Lara Lorenz, Sarah Brendel, Ivy Nortey, Friederike Seeger Produktion: Rufus Zoller **********Quellen:Freudinger, M. (2023). Persönlichkeit, Prokrastination und Prüfungsangst als Prädiktoren für Studienerfolg. die hochschullehre, Jahrgang 9/2023. DOI: 10.3278/HSL2319W Siemonsen, K. & Stelzer, J. (2025). Prüfungsangst im Studiums.  In:  API Magazin 6(1) [Online]. DOI: 10.15460/apimagazin.2025.6.1.2341. Bischofsberger, L. (2022). Prävalenz und Ausprägungen von Prüfungsangst Bei Studienanfänger/-Innen der Medizin [Dissertation]. Institut für Anatomie, Funktionelle und Klinische Anatomie der Medizinischen Fakultät der Friedrich-Alexander-Universität Erlangen-Nürnberg, 2022Silaj, K.M., Schwartz, S.T., Siegel, A.L.M. et al. (2021). Test Anxiety and Metacognitive Performance in the Classroom. Educ Psychol Rev 33, 1809–1834.Liu, Y., Pan, H., Yang, R. et al. (2021) The relationship between test anxiety and emotion regulation: the mediating effect of psychological resilience. Ann Gen Psychiatry 20, 40.**********Mehr zum Thema bei Deutschlandfunk Nova:Prüfungen - Wie wir unser Hirn beim Lernen austricksenStudium: Wie wir den Prüfungsmarathon schaffenErst am Ziel, dann im Eimer: Wenn wir in ein Loch fallenGegen Nervosität: Hundestreicheln gegen Prüfungsstress**********Dieses Thema belastet dich?Hier findest du eine Übersicht zu Hilfsangeboten**********Den Artikel zum Stück findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: TikTok und Instagram .**********Meldet euch!Ihr könnt das Team von Facts & Feelings über Whatsapp erreichen.Uns interessiert: Was beschäftigt euch? Habt ihr ein Thema, über das wir unbedingt in der Sendung und im Podcast sprechen sollen?Schickt uns eine Sprachnachricht oder schreibt uns per 0160-91360852 oder an factsundfeelings@deutschlandradio.de.Wichtig: Wenn ihr diese Nummer speichert und uns eine Nachricht schickt, akzeptiert ihr unsere Regeln zum Datenschutz und bei Whatsapp die Datenschutzrichtlinien von Whatsapp.

BUFFALO, NY — October 21, 2025 — A new #editorial was #published in Aging-US on October 13, 2025, titled “Longevity clinics: between promise and peril.” In this editorial, Marco Demaria, Editor-in-Chief of Aging-US, from the European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), University of Groningen (RUG), reviews the rapid rise of longevity clinics worldwide. Longevity clinics have emerged globally in response to increasing demand for personalized, preventive healthcare. Located in countries such as the United States, Switzerland, and the United Arab Emirates, these centers offer advanced diagnostic services, including genomic testing, advanced imaging, and multi-omics profiling. Their goal is to extend healthspan—the number of years a person lives in good health—through customized lifestyle interventions, nutritional guidance, and, in some cases, experimental therapies. “Longevity clinics embody an important vision: healthcare is personalized, preventive, and engaged.” Although the concept of proactive aging care is attractive, the editorial raises serious concerns about the scientific and ethical foundations of these clinics. Many operate outside conventional medical systems and lack connections to academic geroscience. This disconnection allows them to market expensive interventions without sufficient clinical validation. Program costs can range from €10,000 to over €100,000 per year, limiting access to wealthy individuals while leaving out populations most at risk for premature aging. Despite these challenges, Dr. Demaria notes that longevity clinics may contribute meaningfully to innovation. By collecting extensive, long-term health data from clients, these clinics have the potential to identify early biomarkers of aging and detect signs of age-related diseases. Unlike traditional clinical trials, which are limited in scope and duration, longevity clinics track a wide range of health data over time. When paired with artificial intelligence tools, this information could help advance the science of healthy aging. However, several risks remain. Many clinics lack standardized protocols, and the tools they use, such as biological age calculators or hormone therapies, often lack accuracy or clear clinical value. Without proper guidelines, clients may receive advice that is confusing or not scientifically supported. This can reduce public trust in the broader field of longevity research. To ensure these clinics contribute positively to health innovation, the editorial outlines different key steps: greater collaboration with academic researchers, the adoption of standardized protocols, increased transparency, and work toward regulatory clarity. Broader access must also be considered by developing scalable and more affordable models, possibly through partnerships with public health systems. Ultimately, longevity clinics represent both a major opportunity and a serious concern. If integrated responsibly with science, policy, and public health, they could support a shift toward personalized, preventive healthcare. Without this alignment, however, they risk reinforcing inequality and weakening the credibility of the science behind aging. DOI - https://doi.org/10.18632/aging.206330 Corresponding author - Marco Demaria — m.demaria@umcg.nl Abstract video - https://www.youtube.com/watch?v=Bt84xBdii0s To learn more about the journal, visit https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY – October 20, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on October 16, 2025, titled “Widespread folate receptor expression in pediatric and adolescent solid tumors – opportunity for intraoperative visualization with the novel fluorescent agent pafolacianine.” In this study, led by first author Ashley C. Dodd from Ann & Robert H. Lurie Children's Hospital and corresponding author Timothy B. Lautz from the same institution and Northwestern University Feinberg School of Medicine, researchers discovered that folate receptor beta (FRβ) is widely expressed in various pediatric and adolescent solid tumors. This finding highlights FRβ as a promising target for improving the accuracy of tumor surgery using a fluorescent imaging agent known as pafolacianine. Pediatric cancers are often challenging to remove completely during surgery, particularly when tumors spread or form small metastases. Fluorescence-guided surgery is a method that helps surgeons better identify tumors during operations using special imaging dyes. However, commonly used dyes such as indocyanine green are not tumor-specific and rely on general features of blood vessel permeability, limiting their precision. In this study, researchers investigated the potential of pafolacianine, a next-generation dye that targets folate receptors, for pediatric use. Folate receptors are proteins commonly found on the surface of cancer cells. Pafolacianine is already FDA-approved for adults with ovarian and lung cancers due to its ability to bind these receptors and highlight tumors during surgery. The research team analyzed tissue samples from 13 young patients diagnosed with various cancers, including Wilms tumor, osteosarcoma, synovial sarcoma, rhabdomyosarcoma, Ewing sarcoma, and neuroblastoma. The results showed that FRα was predominantly absent, whereas FRβ was present in 100% of the tumor samples. Notably, FRβ appeared both on the tumor cells and in the surrounding tumor microenvironment but showed little to no expression in normal tissue, making it an excellent candidate for targeted imaging. “In this study, we performed immunohistochemistry staining on slides obtained from a range of pediatric patients with solid tumors.” This consistent expression of FRβ in pediatric tumors is a significant and novel finding. Earlier studies primarily linked FRβ to immune cells called tumor-associated macrophages. This study reveals that FRβ is also expressed directly on tumor tissue, which could help surgeons better distinguish cancer from healthy tissue during procedures. Based on these results, the team has launched a clinical trial to evaluate pafolacianine in children undergoing surgery for metastatic lung tumors. If successful, this method could make pediatric cancer surgery safer and more effective. Overall, this study suggests that targeting FRβ with pafolacianine could serve as a tumor-agnostic imaging strategy, applicable across a wide range of pediatric solid tumors. This represents a potential advancement in real-time surgical imaging and a step forward in pediatric cancer care. DOI - https://doi.org/10.18632/oncotarget.28772 Correspondence to - Timothy B. Lautz - TLautz@luriechildrens.org Abstract video - https://www.youtube.com/watch?v=0its0QkOcwM Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Diese Vorlesung bietet eine umfassende Einführung in die aktuellen Entwicklungen der Konstruktionsgrammatik, eine der zentralen Theorien der kognitiven Linguistik. Im Mittelpunkt steht die Annahme, dass Sprache aus „Konstruktionen“ besteht – konventionalisierten Paarungen von Bedeutung und Form. Die Vorlesung wird durch zwei Schwerpunktsetzungen gekennzeichnet sein. Zum einen ist das die enge Verbindung der Konstruktionsgrammatik mit der Framesemantik. Die Framesemantik kann konstruktionelle Analysen ideal ergänzen, indem sie die konzeptuellen Grundlagen sprachlicher Bedeutung detailliert erschließt. Wir untersuchen, wie Konstruktionen und Frames, Wissensrahmen, in Relation zueinander stehen. Zum anderen widmet sich die Vorlesung der Konstruktikographie. Dieses Gebiet verbindet die theoretischen Erkenntnisse der Konstruktionsgrammatik mit den Methoden der praktischen Lexikographie, um „Konstruktika“ – umfassende Verzeichnisse von Konstruktionen – zu beschreiben. Wir werden Ziele und Methoden der Konstruktikographie erörtern, einschließlich korpusbasierter Workflows, Annotationspraktiken und der Strukturierung von Konstruktionsbeschreibungen.Präsentation (*.pdf): Alexander Lasch. 2025. Konstruktionsgrammatik. Zenodo. DOI: https://doi.org/10.5281/zenodo.17370032. Videoaufzeichnungen: ⁠⁠⁠⁠⁠⁠⁠https://youtube.com/@AlexanderLasch⁠⁠⁠⁠⁠⁠⁠. Informationen & Material zu allen Vorlesungen: ⁠⁠⁠⁠⁠⁠⁠https://kurzelinks.de/fl7f⁠⁠⁠⁠⁠⁠⁠. Worksheet zu den Vorlesungen: ⁠https://kurzlinks.de/WorksheetVorlesungen⁠. Intro: "Reflections" von Scott Holmes (CC BY via ⁠⁠⁠⁠⁠⁠FMA⁠⁠⁠⁠⁠⁠).#Linguistik #OER #Sprache #Sprachwissenschaft #Grammatik #Konstruktionsgrammatik

On March 7, 2025, we released an episode summarizing key aspects of a NEJM publication regarding male partner therapy for women with recurrent BV. Although that study had limitations, the results were very surprising. Now, on 10/16/25 (7 months later), the ACOG has a new Clinical Practice Update (CPU) on this very issue. In this episode we will briefly summarize that March 2025 NEJM publication and highlight the TWO updated clinical recommendations from the ACOG regarding male partner therapy for the prevention of BV in women. PLUS, we will briefly discuss why although male partner therapy should be considered, partner EPT is “not recommended” at this time by the ACOG. 1. ACOG CLINICAL PRACTICE UPDATE: Concurrent Sexual Partner Therapy to Prevent Bacterial Vaginosis Recurrence Obstetrics & Gynecology ():10.1097/AOG.0000000000006102, October 16, 2025. | DOI: 10.1097/AOG.00000000000061022. Chapa Clinical Pearls March 2025 Episode: https://open.spotify.com/episode/4sW9tTe9CdYVQsCRBjqQQP3. Vodstrcil LA, Plummer EL, Fairley CK, Hocking JS, Law MG, Petoumenos K, et al. Male-partner treatment to prevent recurrence of bacterial vaginosis. N Engl J Med 2025;392:947–57. doi: 10.1056/NEJMoa2405404STRONG COFFEE PROMO: 20% Off Strong Coffee Company https://strongcoffeecompany.com/discount/CHAPANOSPINOBG

This week we review an episode from 3 years back and delve into the world of adult congenital heart disease when we review a recent work from the ACHD team at UCSF that assesses the impact of BMI on clinical outcomes in the single ventricle adult Fontan patient. What is the cause of elevation in BMI in some Fontan patients? Is obesity the only explanation? Is BMI a modifiable risk factor for our Fontan patients and should exercise be 'prescribed' for these patients? If so prescribed, what type of exercise is best for the Fontan patient? This week's work's senior author, Dr. Anushree Agarwal, Assistant Professor of Medicine at UCSF, shares her insights into this important topic. DOI: 10.1161/JAHA.122.026732Also mentioned in today's episode is episode #222 with Dr. Dan Halpern of NYU medical center (https://www.stitcher.com/show/pediheartpediatric-cardiology-today/episode/pediheart-podcast-222-impact-of-cardiac-rehab-on-exercise-tolerance-in-the-achd-patient-206781483)

Interviewees: Matthew Sullivan, PhD, Assistant Director of Disability Resources, Washington University School of Medicine in St. Louis Suchita “Suchi” Rastogi, PhD. MPH Candidate, University of Illinois Chicago; CEO, Disability in Medicine Mutual Mentorship Program Interviewer: Lisa Meeks, PhD, MA, Guest Editor, Academic Medicine Supplement on Disability Inclusion in Undergraduate Medical Education Description: In this episode of Stories Behind the Science, Dr. Lisa Meeks talks with Matt Sullivan (Washington University School of Medicine) and Suchita “Suchi” Rastogi (UIC; DM3P) about their paper, “Standardized Language for Clinical Accommodations in U.S. Undergraduate Medical Training: Results From a National Modified Delphi Consensus Study,”part of the Academic Medicine supplement on Disability Inclusion in UME. Their conversation explores how a grassroots idea—born from students' lived experiences and practitioners' urgent need for clarity—grew into the first national, evidence-based language guide for clinical accommodations. Together, they unpack how a modified Delphi process brought students, Disability Resource Professionals, and leaders together to build consensus around the precise language that transforms intention into implementation. The trio discuss how language and word choices can make the difference between support and confusion, and how transparent, shared language strengthens trust and access for all. Dr. Meeks, Sullivan, and Rastogi also reflect on the collaborative model that made this project possible—one that centers disabled voices, encourages vulnerability in leadership, and demonstrates how clarity in communication is the foundation of equity. Listeners will come away with practical takeaways for institutions and leaders: audit your accommodation templates, build structured partnerships between DRPs and Student Affairs, and engage students as co-creators in designing accessible clinical environments. Transcript: https://docs.google.com/document/d/1ooJ5TP8V8s4t35EECoWHNTta7qqwbKlx-Fgu_WIiPG4/edit?usp=sharing Bios: Matt Sullivan PhD Dr. Sullivan is the Assistant Director of Disability Resources, At Washington University in St. Louis, and serves as DR's liaison to WashU's School of Medicine, acting as the primary contact for SoM faculty/staff, students, and prospective students.  In this role, Matt works closely with all parties to create an accessible and inclusive educational environment for disabled students pursuing their degrees within Health Sciences and Medicine. Dr. Sullivan is a research-oriented practitioner dedicated to promoting disability awareness and inclusion within the higher education environment.  In his student affairs roles, Dr. Sullivan has experience providing leadership and direction for a variety of programs and services in the areas of disability, testing, tutoring, Supplemental Instruction, and academic coaching.  Working in the field of disability services for more than a decade, Matt has dedicated his time and energy to the education and development of students, faculty, and staff surrounding the intersectionality of disability with race, culture, gender, and other prominent identity factors. Suchita “Suchi” Rastogi PhD Suchi is an MPH student at the University of Illinois Chicago and CEO of the Disability in Medicine Mutual Mentorship Program (DM3P). A former MD-PhD student at Stanford University, she advocates for accessible medical education and leads community-based efforts to promote disability inclusion and peer mentorship. As a South Asian disability activist, she values health equity and compassionately designed systems that serve all people with dignity. She believes everyone deserves respect, access to material resources, and psychosocial support. These values compel her to improve healthcare and public health infrastructure for disabled patients, increase disability representation in medicine, and shift attitudes towards persons with disability. To accomplish this, she 1) run a mentorship program (DM3P) for healthcare professionals with disability, 2) conducts disability health equity research, and 3) advocates for evidence-based policies that center accessibility. Key Words: Clinical accommodations · Disability inclusion · Medical students · Disability Resource Professionals ADA Resources: Article from Today's Talk: Dhanani Z, Rastogi S, Sullivan M, Betchkal R, Poullos P, Meeks LM. Standardized Language for Clinical Accommodations in U.S. Undergraduate Medical Training: Results From a National Modified Delphi Consensus Study.Academic Medicine. 2025;100(10S):S92–S97. DOI: 10.1097/ACM.0000000000006150 Read the full article here → Equal Access for Students with Disabilities: The Guide for Health Science and Professional Education (2nd Ed). Meeks LM, Jain NR, & Laird EP. Springer Publishing, 2020. Read here → The Docs With Disabilities Podcast: https://www.docswithdisabilities.org/docswithpodcast

BUFFALO, NY — October 17, 2025 — A new #research paper was #published in Volume 17, Issue 9 of Aging-US on September 8, 2025, titled, “Runx1 overexpression induces early onset of intervertebral disc degeneration.” In this study, led by first author Takanori Fukunaga from Emory University School of Medicine and corresponding author Hicham Drissi from Emory and the Atlanta VA Medical Center, researchers found that the Runx1 gene, when overactive in spinal disc cells, can accelerate age-related degeneration of the intervertebral discs. The findings offer new insight into the genetic factors that drive disc aging and suggest possible directions for treating chronic back pain. Intervertebral discs cushion the spine and support movement. Their deterioration is a major cause of lower back pain, especially with aging. At the center of each disc is the nucleus pulposus (NP), a gel-like core that contains proteins such as collagen and aggrecan, which help retain water and maintain structure. As people age, NP cells often lose their function, contributing to disc breakdown. Using a genetically modified mouse model, the researchers activated Runx1 specifically in NP cells. These mice developed signs of disc degeneration by five months of age, which is much earlier than normal. The overexpression of Runx1 led to the loss of healthy NP cells, an increase in abnormal cell types, and damage to disc structure. Levels of essential proteins like aggrecan and type II collagen decreased, while type X collagen increased, signaling unhealthy tissue changes. “To achieve NP-specific postnatal overexpression of Runx1, we crossed Krt19CreERT mice with Rosa26-Runx1 transgenic mice previously generated in our laboratory.” A key finding was that Runx1 overactivity did not kill cells directly. Instead, it caused premature cellular aging, known as senescence. Senescent cells lose the ability to repair tissue, creating an environment that accelerates degeneration. Markers of senescence were significantly elevated in the affected discs. The researchers also observed a dose-dependent response. The more Runx1 was activated, the more severe the degeneration was. This suggests that targeting Runx1 may be a promising strategy to prevent or slow disc aging. Overall, this study highlights the genetic and cellular processes that contribute to intervertebral disc degeneration, a leading cause of disability. By identifying Runx1 as a potential driver of early disc aging, the research opens new opportunities for intervention and treatment of degenerative spine conditions. DOI - https://doi.org/10.18632/aging.206316 Corresponding author - Hicham Drissi - hicham.drissi@emory.edu Abstract video - https://www.youtube.com/watch?v=BPwWbVBPIUM Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206316 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - cell senescence, aging, Runx1, nucleus pulposus, intervertebral disc degeneration To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@Aging-US LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Podcast family, as we have said on many previous occasions, we get episode suggestions from either real-world patient encounters, from things that are hot in press, and/or from podcasts family member suggestions. Recently, one of our podcast family members asked me about the utility ofperforming pelvic floor muscle therapy (PFMT) antepartum. Is this evidence-based? Does performing PFMT help with postpartum urinary incontinence? Not all PFMTs are Kegel exercises! In this episode, we will review peripartum urinary incontinence and answer the question, “Is there value in teaching antepartum PFMT?”. We will summarize key concepts from the Oct 2025 Narrative Review on thissubject from the Green Journal (Obstet Gynecol).1.     Siddique, Moiuri MD, MPH; Hickman, Lisa MD;Giugale, Lauren MD. Peripartum Urinary Incontinence and Overactive Bladder.Obstetrics & Gynecology 146(4):p 466-472, October 2025. | DOI:10.1097/AOG.00000000000059932.     Woodley SJ, Lawrenson P, Boyle R, et al. PelvicFloor Muscle Training for Preventing and Treating Urinary and Faecal Incontinence in Antenatal and Postnatal Women. The Cochrane Database of SystematicReviews. 2020;5:CD007471. doi:10.1002/14651858.CD007471.pub4.3.     Pelvic Floor Muscle Training to Prevent andTreat Urinary and Fecal Incontinence in Antenatal and Postnatal Patients. AmericanAcademy of Family Physicians (2021). Practice Guideline STRONG COFFEE PROMO: 20% Off Strong CoffeeCompany https://strongcoffeecompany.com/discount/CHAPANOSPINOBG

In this episode of the RCP Medicine Podcast, Consultant Respiratory Physician Milind Savani joins Respiratory Registrar Daniella Draicchio and Foundation Doctor Masooma Ali to explore a compelling case of progressive breathlessness in a 45-year-old woman. What begins as a seemingly routine presentation unfolds into a diagnostic journey.Together, the team discusses the challenges of diagnosing chronic type 2 respiratory failure, the importance of recognising paradoxical breathing, and the role of non-invasive ventilation and surgical intervention. This episode is a masterclass in clinical reasoning, multidisciplinary collaboration, and the value of thorough bedside examination.ReferencesA retrospective cohort study of idiopathic diaphragmatic palsy: a diagnostic triad, natural history and prognosis ERJ Open Research 2021 00953-2020; DOI: https://doi.org/10.1183/23120541.00953-2020 Diagnosis and management of nontraumatic unilateral diaphragmatic paralysis (complete or partial) in adults - UpToDateTreatment of diaphragmatic paralysis using an expanded surgical protocol: review of the largest worldwide experience  European Respiratory Journal 2018 52 (suppl 62): PA806; DOI: https://doi.org/10.1183/13993003.congress-2018.PA806 Diaphragm dysfunction: how to diagnose and how to treat? Breathe 2025 21(1): 240218; DOI: https://doi.org/10.1183/20734735.0218-2024 This podcast has been made with an educational grant from Bristol-Myers Squibb Pharmaceuticals Limited (“BMS”). BMS has had no input or involvement in the design, development or content of the podcast whatsoever.RCP Links Education Events Membership Improving care Policy and campaigns RCP Social Media Instagram LinkedIn Facebook X Bluesky Music: Episode 50 onward - Bensound.com Episodes 1 - 49 'Impressive Deals' - Nicolai Heidlas

In the 09/1/2018 Society for Academic Specialists in General Obstetrics and Gynecology's (SASGOG's) Pearls of Exxcellence publication, “Management of Preeclampsia at Term”, it states: “If hypertension management requires acute IV treatment, it is often prudent to initiate oral labetalol or EXTENDED-release nifedipine to maintain blood pressures below the severe range. Intrapartum blood pressure management and consultation should not delay progress towards delivery. Fetal monitoring should be continuous.” In the original ACOG CO 692 from 2017, oral nifedipine was first referenced as an alternative to IV meds GIVEN INTRAPARTUM, stating, “Although relatively less information currently exists for the use of calcium channel blockers for this clinical indication, the available evidence suggests that immediate release oral nifedipine also may be considered as a first-line therapy, particularly when intravenous access is not available.” This may be given orally as 10mg, 20mg, and 20 mg separated in time by 20 minutes per dose. Notice it says “immediate release oral nifedipine”. But what about EXTENDED release nifedipine intrapartum as stated by the SASGOG? Is that an option after immediate attentive and therapy has been given with IV anti-hypertensives? Listen in for details.1. Emergent Therapy for Acute-Onset, Severe Hypertension During Pregnancy and the Postpartum Period: Committee Opinion, Number 692. Obstetrics & Gynecology 129(4):p e90-e95, April 2017. | DOI: 10.1097/AOG.00000000000020192. Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin, Number 222. Obstet Gynecol. 2020 Jun;135(6):e237-e260. doi: 10.1097/AOG.0000000000003891. PMID: 32443079.3. Cleary EM, Racchi NW, Patton KG, Kudrimoti M, Costantine MM, Rood KM. Trial of Intrapartum Extended-Release Nifedipine to Prevent Severe Hypertension Among Pregnant Individuals With Preeclampsia With Severe Features. Hypertension. 2023 Feb;80(2):335-342. doi: 10.1161/HYPERTENSIONAHA.122.19751. Epub 2022 Oct 3. PMID: 36189646.STRONG COFFEE PROMO: 20% Off Strong Coffee Company ⁠https://strongcoffeecompany.com/discount/CHAPANOSPINOBG

BUFFALO, NY – October 14, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on October 13, 2025, titled “Treatment of glioblastoma with tumor-specific amplitude-modulated radiofrequency electromagnetic fields.” The study, led by Hugo Jimenez from Wayne State University School of Medicine, Karmanos Cancer Institute, introduces a novel treatment approach for glioblastoma, an aggressive and often treatment-resistant brain cancer. The findings open a new potential path for patients who currently have limited therapeutic options. The approach uses a device developed by TheraBionic that delivers extremely low levels of radiofrequency electromagnetic fields, tuned to frequencies associated with glioblastoma. In laboratory experiments, this therapy significantly slowed the growth of multiple glioblastoma cell lines. It was especially effective against tumor stem cells, which are known to resist standard treatments and drive cancer reappearance. Researchers also found that the treatment's effects depend on a calcium channel in tumor cells known as Cav3.2 (CACNA1H). When this channel was blocked, the therapy lost its effectiveness, highlighting the channel's essential role in how tumor cells respond to the signal. The therapy also disrupted the process of cell division by interfering with the mitotic spindle, a structure critical for cell replication. This disruption was associated with changes in the expression of genes that regulate cell division, particularly those involved in the “Mitotic Roles of Polo-Like Kinase” pathway. These effects were specific to tumor-targeted frequencies, as non-matching signals had no measurable impact. The study also includes data from two patients with difficult-to-treat brain tumors who received the therapy through compassionate use. One patient with recurrent glioblastoma showed signs of clinical and radiographic improvement after one month of treatment. Another patient with oligodendroglioma tolerated the therapy well and had stable disease during follow-up imaging. Neither patient experienced serious side effects, further supporting the safety of the therapy. “There was evidence of clinical and radiological benefit in a 38-year-old patient with recurrent GB and evidence of safety and feasibility in a 47-year-old patient with oligodendroglioma.” This is the first study to demonstrate that tumor-specific radiofrequency therapy can suppress both tumor growth and cancer stem cells in glioblastoma. Similar results had previously been observed in liver and breast cancers. These findings contribute to the growing body of evidence supporting a new class of systemic, non-toxic cancer therapies. Further clinical trials will be crucial to confirm these results and fully assess the potential of this approach for treating brain cancer. DOI - https://doi.org/10.18632/oncotarget.28770 Correspondence to - Hugo Jimenez - hugo.jimenez@wayne.edu Abstract video - https://www.youtube.com/watch?v=uxYnWcNKYfg Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28770 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, oncology, amplitude-modulated radiofrequency electromagnetic fields, glioblastoma, TheraBionic, CACNA1H, Cav3.2 To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Feasibility of a Smartphone App with Mindfulness Training for Adolescent Smoking Cessation: Craving to Quit (C2Q)-TeenIn this episode, Dr. Jud highlights a groundbreaking pilot study that examines the feasibility of a mindfulness-based smoking cessation app tailored for teenagers. Based on the paper Feasibility of a Smartphone App with Mindfulness Training for Adolescent Smoking Cessation: Craving to Quit (C2Q)-Teen by Lori Pbert et al., the episode delves into how mindfulness helps teens recognize and manage cravings. Despite similar abstinence rates across the app, a non-mindfulness app, and written materials, the Craving to Quit app stood out for reducing cigarette consumption in adolescents who continued to smoke. Dr. Jud explores the implications of these findings and the potential of app-based mindfulness interventions to provide accessible and impactful smoking cessation tools for adolescents.Reference:Pbert, L., Druker, S., Crawford, S., Frisard, C., Trivedi, M., Osganian, S. K., & Brewer, J. Feasibility of a Smartphone App with Mindfulness Training for Adolescent Smoking Cessation: Craving to Quit (C2Q)-Teen. Mindfulness. 2019. DOI: 10.1007/s12671-019-01273-wLet's connect on Instagram

This week we review a recent work from the "Women In Pediatric Cardiology" group which is a 4 year old initiative to help lift up women pediatric cardiologists through the fostering of connections and also via mentorship programs. Why did this program develop and what are the most pressing issues affecting female pediatric cardiologists? What are the best solutions to help address gender inequities in our field? We speak with two co-authors of this week's work, Drs. Sarah Ford of Brown University and Kristin Laraja of University of Massachussetts. For those interested in participating in their work, feel free to email  Pediheart@gmail.com and your information will be passed along to the authors. DOI: 10.1007/s00246-024-03576-9

In our latest episode, Associate Editor Dr. Jason Carter (Baylor University, Robbins College of Health and Human Sciences) interviews authors Dr. Alex Carll and Brittany Reynolds (University of Louisville School of Medicine), along with expert Dr. Jessica Bradshaw (University of North Texas Health Science Center), about the recent work by Reynolds et al. There are an estimated 68 million e-cigarette users worldwide, and the use of e-cigarettes during pregnancy has been on a steady rise in recent years. Evidence shows that 1 in 5 smokers or ex-smokers who become pregnant use e-cigarettes during pregnancy, yet the effects of vaping on maternal health during and after pregnancy are poorly understood. Reynolds et al. developed a preclinical mouse model of e-cigarette use during pregnancy to assess maternal autonomic control and ventricular arrhythmias, which further solidifies the relevance of animal research to the NIH mission to enhance health, lengthen life, and reduce illness and disability. The authors measured the dams at 3 weeks postpartum and found lasting increases in catecholamines, which indicates increased sympathetic activation. In addition, the authors found increases in the occurrence of spontaneous ventricular premature beats, which are indications of increased risk for sudden cardiac death and heart failure. What impact does vaping have on maternal cardiovascular health, both during pregnancy and in the postpartum period? Listen now to find out more.   Brittany R. Reynolds, Sean M. Raph, Anand Ramalingam, Shweta Srivastava, Pawel Lorkiewicz, Lillian E. Watson, Kenneth R. Brittian, Helen E. Collins, and Alex P. Carll Don't go vaping my heart: e-cigarette exposure during pregnancy promotes peripartum ventricular arrhythmias and sympathetic dominance Am J Physiol Heart Circ Physiol, published September 22, 2025. DOI: 10.1152/ajpheart.00509.2025

Interviewee: Erick Hung, MD, Professor of Clinical Psychiatry and Associate Dean for Students, University of California San Francisco School of Medicine Interviewer: Lisa Meeks, PhD, MA, Guest Editor, Academic Medicine Supplement on Disability Inclusion in Undergraduate Medical Education Description: In this episode of Stories Behind the Science, Dr. Lisa Meeks talks with Dr. Erick Hung (UCSF) about his paper, “Promoting Disability Inclusion Through an Expanded Conceptual Framework of the Learning Environment,” part of the Academic Medicine supplement on Disability Inclusion in UME. Their conversation explores how a single student story at UCSF sparked a full-scale rethinking of what it means to create an equitable learning environment. Dr. Hung walks us through the journey—from a campus task force to a conceptual framework that now guides systemic change nationwide. Together, they unpack the six domains of the learning environment, including a new and critical addition: the societal layer, which recognizes how broader cultural forces shape belonging, access, and success. The discussion touches on mentorship, student advocacy, technical standards reform, and what it means to move beyond compliance toward culture change. Dr. Hung also reflects on humility in leadership, the importance of systems thinking, and how conceptual frameworks become living roadmaps for equity. Listeners will come away with practical takeaways for schools and leaders—build peer networks, re-evaluate policies through an inclusion lens, and invite students into the co-creation of change. Transcript: https://docs.google.com/document/d/1aO6cvl-_b82AONsV7V4LmS1Y8r6sI8zVtWKzWPlHakw/edit?usp=sharing Bios: Erick Hung, MD is Professor of Clinical Psychiatry and Associate Dean for Students at UCSF School of Medicine. A UCSF graduate and psychiatrist by training, he has led major institutional efforts to foster student well-being, belonging, and disability inclusion. His scholarship and leadership focus on systems approaches to learner flourishing, inclusive learning environments, and advocacy for equitable policy reform in medical education. Key Words: Learning environment Disability inclusion Medical students Systems thinking Societal drivers Technical standards Belonging Well-being Institutional change Resources: Article from Today's Talk: Theall, Alexandra C.P.; Crandall, Joanne E., MD; Gamboa, Haley N., MS, MD; Chichioco, Michael; Hughes, Sarah E.; Gruppen, Larry, PhD; Hung, Erick, MD. Promoting Disability Inclusion Through an Expanded Conceptual Framework of the Learning Environment. Academic Medicine, 100(10S): S84-S91, October 2025. DOI: 10.1097/ACM.0000000000006148 Read the full article here The Docs With Disabilities Podcast: https://www.docswithdisabilities.org/docswithpodcast  

BUFFALO, NY – October 8, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on October 6, 2025, titled “ACTM-838, a novel systemically delivered bacterial immunotherapy that enriches in solid tumors and delivers IL-15/IL-15Rα and STING payloads to engage innate and adaptive immunity in the TME and enable a durable anti-tumor immune response.” In this study, led by first author Kyle R. Cron and corresponding author Akshata R. Udyavar, researchers from Actym Therapeutics developed a new form of bacterial immunotherapy called ACTM-838. This treatment safely delivers immune-activating proteins directly to solid tumors. The approach may offer a new option for cancer patients whose solid tumors are resistant to current immunotherapies. Solid tumors often suppress the immune system, making it difficult for treatments like immune checkpoint inhibitors to work effectively. ACTM-838 was designed to overcome this challenge by targeting phagocytic immune cells within the tumor microenvironment (TME). Once inside the tumor, the therapy delivers two immune-stimulating components: IL-15/IL-15Rα and a modified version of STING. Both are known to activate the body's innate and adaptive immune responses. This combination of immune-stimulating proteins helps shift the TME from immune-suppressive to immune-permissive, enabling the body's natural defenses to fight the cancer. “STACT is a modular, genetically engineered live attenuated S. Typhimurium bacterial platform that enables tissue-specific localization and cell-targeted delivery of large, multiplexed payloads via systemic administration.” The study highlights how ACTM-838, built on a specially modified strain of Salmonella Typhimurium, safely targets tumors and avoids healthy tissue after intravenous injection. This targeted delivery reduces the risk of side effects while ensuring the immune-boosting agents reach their intended location. Importantly, ACTM-838 also showed significantly reduced inflammatory toxicity compared to its parent bacterial strain, which had previously presented challenges in clinical use. In preclinical tests, ACTM-838 shrank tumors and prevented their recurrence after treatment. Mice that were cured of tumors resisted re-injection with cancer cells, suggesting the development of long-lasting immune memory. The therapy also showed strong synergy with anti-PD1 drugs, a widely used class of cancer treatments, further improving outcomes in both treatment-resistant and responsive tumor models. Researchers also found that ACTM-838 changed the composition of immune cells within the tumor. It increased beneficial cells like cytotoxic T-cells and antigen-presenting macrophages, while reducing suppressive cell types such as regulatory T-cells and exhausted T-cells. These effects were confirmed through genetic analysis and cellular studies, pointing to a broad and coordinated immune response. This study offers proof-of-concept that live bacterial therapy can safely and effectively deliver gene-based immune modulators directly to tumors. With ACTM-838 now being tested in a Phase I clinical trial, the findings offer a new direction for cancer treatment strategies that activate the body's own immune system, particularly in difficult-to-treat cases where other therapies fail. DOI - https://doi.org/10.18632/oncotarget.28769 Correspondence to - Akshata R. Udyavar - akshata.udyavar@pfizer.com Abstract video - https://www.youtube.com/watch?v=fr5OR3tvC_I Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

“How do we work with gravity to be healthier and stronger?” explains Brennan Spiegel, M.D. Brennan Spiegel, M.D., a physician and professor whose work is focused on how emotion, physical experience, and the mind-body connection shape health, joins us today to explore the emerging field of biogravitational medicine and what it reveals about our relationship with gravity, the body, and health. - What is biograviational medicine? (~3:30) - The connection between health & biogravitational forces (~4:45) - How Spiegel got interested in this topic (~6:40) - How gravity affects IBS (~8:15) - What is EDS? (~12:00) - Holistic approach to gut health (~14:10) - The role of the microbiome & biogravitational medicine (~18:20) - The overarching role of gravity in our health (~24:00) - How to optimize your health through gravity (~26:00) - The effect on mental health (~31:10) -  A protocol for mental resilience (~34:00) - His current research (~35:30) - Accessible ways to improve your health through gravity (~39:35) - The mind-body connection (~41:45) - The role of HRV (~43:35) - Spiegel's dream study (~45:40) - The future of the field (~48:50) Referenced in the episode:  - Follow Spiegel on Instagram (@brennan_spiegel)  - Learn more about Spiegel (www.BrennanSpiegelMD.com)  - Pick up his book, Pull: How Gravity Shapes Your Body, Steadies the Mind, and Guides Our Health. - Check out his podcast (https://thegravitydoctors.com/)  - What's my Gravitype Quiz: https://chatgpt.com/g/g-68a51addf2cc819191559f3fd61d9e7d-what-s-my-gravitype  - Research on gravity's effect on the gut (DOI: 10.14309/ajg.0000000000002066)  - Research on mental gravity (https://doi.org/10.3390/e25091275) We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

This week we review a recent multicenter, randomized trial pitting 2 different immunosuppressive therapeutic approaches against each other. How did a novel approach of everolimus + low dose tacrolimus compare to more standard MMF + standard, higher dose tacrolimus in avoidance of major adverse transplant events or complications? How did this first ever prospective trial in the pediatric heart transplantation world start and how difficult was it to perform in the absence of corporate or NIH support? Why can these data help inform FDA labelling for this novel approach and why is this important? Dr. Kevin Daly of Boston Children's Hospital shares his deep insights into this work this week!DOI: 10.1001/jama.2025.14338

Husband-and-wife team William Firth Wells and Mildred Weeks Wells conducted research that had the potential to make a big difference in the safety of indoor air. But it didn’t really have a significant impact on public health. Research: Associated Press. “Super-Oyster Is On its Way to Dinner Table Bigger and Better Bivalve Sports Pedigree.” 3/13/1927. https://www.loc.gov/resource/sn84020064/1927-03-13/ed-1/?sp=14 “Brought Back to Texas.” The Houston Semi-Weekly Post. 12/26/1889. https://www.newspapers.com/image/1196039760/ Decatur Daily Review. “Scientists Fight Flu Germs with Violet Ray.” 7/30/1936. https://www.newspapers.com/image/94335504/ Evening Star. “Scientific Trap-shooter.” 6/26/1937. https://www.loc.gov/resource/sn83045462/1937-06-26/ed-1/?sp=7&q=William+Firth+Wells&r=0.668,0.557,0.438,0.158,0 Fair, Gordon M. and William Weeks Wells. “Method and Apparatus for Preventing Infection.” U.S. Patent 2,198,867. https://ppubs.uspto.gov/api/pdf/downloadPdf/2198867 Hall, Dominic. “New Center for the History of Medicine Artifact - Wells Air Centrifuge.” Harvard Countway Library. https://countway.harvard.edu/news/new-center-history-medicine-artifact-wells-air-centrifuge “Incubator Is Now Oyster Nurse.” Washington Times. 10/1/1925. https://www.loc.gov/resource/sn84026749/1925-10-01/ed-1/?sp=12 Lewis, Carol Sutton. “Mildred Weeks Wells’s Work on Airborne Transmission Could Have Saved Many Lives—If the Scientific Establishment Listened.” Lost Women of Science Podcast. Scientific American. 5/22/2025. https://www.scientificamerican.com/article/a-public-health-researcher-and-her-engineer-husband-found-how-diseases-can/ Library and Archives Team. “William Firth Wells and Mildred Weeks Wells.” Washington College. https://www.washcoll.edu/people_departments/offices/miller-library/archives-special-collections/archives-blog/Wells%20papers.php Molenti, Megan. “The 60-Year-Old Scientific Screwup That Helped Covid Kill.” Wired. 5/13/2021. https://www.wired.com/story/the-teeny-tiny-scientific-screwup-that-helped-covid-kill/ Perkins JE, Bahlke AM, Silverman HF. Effect of Ultra-violet Irradiation of Classrooms on Spread of Measles in Large Rural Central Schools Preliminary Report. Am J Public Health Nations Health. 1947 May;37(5):529-37. PMID: 18016521; PMCID: PMC1623610. Randall, Katherine and Ewing, E. Thomas and Marr, Linsey and Jimenez, Jose and Bourouiba, Lydia, How Did We Get Here: What Are Droplets and Aerosols and How Far Do They Go? A Historical Perspective on the Transmission of Respiratory Infectious Diseases (April 15, 2021). Available at SSRN: https://ssrn.com/abstract=3829873 Riley, Richard L. “What Nobody Needs to Know About Airborne Infection.” American Journal of Respiratory and Critical Care Medicine. Volume 163, Issue 1. https://www.atsjournals.org/doi/10.1164/ajrccm.163.1.hh11-00 Simon, Clea. “Did a socially awkward scientist set back airborne disease control?” The Harvard Gazette. 3/7/2025. https://news.harvard.edu/gazette/story/2025/03/did-a-socially-awkward-scientist-set-back-airborne-disease-control/ “Texas State News.” McKinney Weekly Democrat-Gazette. 4/17/1890. https://www.newspapers.com/image/65385350/ WELLS MW, HOLLA WA. VENTILATION IN THE FLOW OF MEASLES AND CHICKENPOX THROUGH A COMMUNITY: Progress Report, Jan. 1, 1946 to June 15, 1949, Airborne Infection Study, Westchester County Department of Health. JAMA. 1950;142(17):1337–1344. doi:10.1001/jama.1950.02910350007004 WELLS MW. VENTILATION IN THE SPREAD OF CHICKENPOX AND MEASLES WITHIN SCHOOL ROOMS. JAMA. 1945;129(3):197–200. doi:10.1001/jama.1945.02860370019006 WELLS WF, WELLS MW. AIR-BORNE INFECTION. JAMA. 1936;107(21):1698–1703. doi:10.1001/jama.1936.02770470016004 WELLS WF, WELLS MW. AIR-BORNE INFECTION: SANITARY CONTROL. JAMA. 1936;107(22):1805–1809. doi:10.1001/jama.1936.02770480037010 Wells, W F, and M W Wells. “Measurement of Sanitary Ventilation.” American journal of public health and the nation's health vol. 28,3 (1938): 343-50. doi:10.2105/ajph.28.3.343 Wells, William Firth and Gordon Maskew Fair. Viability of B. coli Exposed to Ultra-Violet Radiation in Air.Science82,280-281(1935).DOI:10.1126/science.82.2125.280.b Wells, William Firth and Mildred Weeks Wells. Measurement of Sanitary Ventilation American Journal of Public Health and the Nations Health 28, 343_350, https://doi.org/10.2105/AJPH.28.3.343 Zimmer, Carl. “Air-Borne: The Hidden History of the Life We Breathe.” Dutton. 2025. See omnystudio.com/listener for privacy information.