Podcasts about DOI

This week we review a recent meta-analysis of studies assessing efficacy of adenosine in children to terminate SVT. Does the PALS recommendation of 100 mcg/kg as a starting dose for SVT management make scientific sense given what we know about the efficacy rates of this dose? Why might inadequate doses be potentially dangerous for children with acute SVT? Is there adequate data to consider changes to the recommended starting dose in this situation? Dose adenosine work well for all forms of tachycardia involving the AV node? Pediatric emergency physician and family medicine physician, Dr. Lais dos Santos of Mossoro', Brazil shares the results of a large scale meta-analysis that she performed and offers some answers to these and other questions. DOI: 10.1007/s00246-026-04281-5

This week we discuss a new approval for pabociclib in HER2-positive disease based on the PATINA trial as well as the use of sacituzumab govitecan + pembrolizumab in TNBC, recently approved based on the ASCENT04/KEYNOTED19 trial. And the concept of T-cell "stemless" is intriguing with possibilities: DOI: 10.1056/NEJMcibr2601002 Learning Oncology Companion: https://www.kelleycpharmd.com/learning-oncology-companion-oncopharm

As colorectal cancer rates rise among younger adults, surgeons are increasingly caring for patients with rectal cancer who are pregnant or hoping to preserve future fertility. With more individuals delaying childbearing, balancing effective cancer treatment with fertility preservation and maternal–fetal safety has become an important clinical challenge. This timely topic was recently highlighted by Dr. Sharon Suwanabol during a presentation at the American Society of Colon and Rectal Surgeons annual meeting 2026. In this episode, we explore the intersection of rectal cancer, fertility, and pregnancy through a multidisciplinary, case-based discussion. We review how surgery, chemotherapy, and pelvic radiation can affect fertility and sexual function in both men and women, and why early counseling and referral to reproductive endocrinology specialists are essential. The discussion also emphasizes that evaluation and treatment during pregnancy can often be performed safely, with care individualized based on tumor stage, gestational age, and the patient's goals and values. Hosts and discussants ·      Dr. Betelhem Yohannes, General surgery resident at the University of Washington ·      Dr. Griffen Allen, General surgery resident at the University of Washington  ·      Dr. Raga Siddharthan, Assistant Professor of Surgery in the Section of Colorectal Surgery at the University of Washington  ·      Dr. Stacey Cohen, Professor in the Division of Hematology and Oncology at the University of Washington and a gastrointestinal medical oncologist at Fred Hutch Cancer Center, specializing in colorectal and other GI cancers. Learning objectives ·      Describe the impact of rectal cancer surgery on fertility, sexual function, and future childbearing potential. ·      Review the effects of chemotherapy and pelvic radiation on reproductive health and fertility preservation. ·      Discuss available fertility preservation strategies and the importance of early pre-treatment counseling and referral. ·      Recognize the diagnostic challenges of rectal cancer during pregnancy, including overlapping gastrointestinal symptoms. ·      Review appropriate staging and workup considerations for suspected rectal cancer in pregnant patients. ·      Discuss multidisciplinary management strategies for rectal cancer during pregnancy, including individualized treatment sequencing. ·      Examine ethical and patient-centered considerations when balancing maternal cancer treatment and fetal outcomes. References  Siegel RL, Wagle NS, Star J, Kratzer TB, Smith RA, Jemal A. Colorectal cancer statistics, 2026. CA Cancer J Clin. 2026;76(2):e70067. doi:10.3322/caac.70067 [https://pubmed.ncbi.nlm.nih.gov/38240409/] Pregnancy at Age 35 Years or Older: ACOG Obstetric Care Consensus No. 11. Obstet Gynecol. 2022;140(2):348-366. doi:10.1097/AOG.0000000000004873 [https://pubmed.ncbi.nlm.nih.gov/35640237/] Stal J, YI SY, Cohen-Cutler S, et al. Fertility Preservation Discussions Between Young Adult Rectal Cancer Survivors and Their Providers: Sex-Specific Prevalence and Correlates. Oncologist. 2022;27(7):579-586. doi:10.1093/oncolo/oyac052 [https://pubmed.ncbi.nlm.nih.gov/35708892/] Druvefors E, Myrelid P, Andersson RE, Landerholm K. Female and Male Fertility after Colectomy and Reconstructive Surgery in Inflammatory Bowel Disease: A National Cohort Study from Sweden. J Crohns Colitis. 2023;17(10):1631-1638. doi:10.1093/ecco-jcc/jjad079 [https://pubmed.ncbi.nlm.nih.gov/37341355/] Ito M, Tsukada Y, Watanabe J, et al. Long-term survival and functional outcomes of laparoscopic surgery for clinical stage I ultra-low rectal cancers located within 5 cm of the anal verge: A prospective phase II trial (Ultimate trial). Ann Surg. Published online April 1, 2024. doi:10.1097/SLA.0000000000006290 [https://pubmed.ncbi.nlm.nih.gov/38629555/] Teh WT, Stern C, Chander S, Hickey M. The impact of uterine radiation on subsequent fertility and pregnancy outcomes. Biomed Res Int. 2014;2014:482968.  Johnson GGRJ, Park J, Helewa RM, Goldenberg BA, Nashed M, Hyun E. Total neoadjuvant therapy for rectal cancer: a guide for surgeons. Can J Surg. 2023 Apr 21;66(2):E196-E201. doi: 10.1503/cjs.005822. PMID: 37085291; PMCID: PMC10125160. [https://pubmed.ncbi.nlm.nih.gov/37085291/] Naren G, Guo J, Bai Q, Fan N, Nashun B. Reproductive and developmental toxicities of 5-fluorouracil in model organisms and humans. Expert Rev Mol Med. 2022 Jan 31;24:e9. doi: 10.1017/erm.2022.3. PMID: 35098910; PMCID: PMC9884763. [https://pubmed.ncbi.nlm.nih.gov/35098910/] National Comprehensive Cancer Network. (2026). NCCN Clinical Practice Guidelines in Oncology: Rectal Cancer (Version 2.2026). Retrieved from NCCN Guidelines for Rectal Cancer [https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1449] Oktay, Kutluk M.D., Ph.D.. Expert Commentary on Fertility Preservation in Colorectal Cancers: Current State and Practical Tips for the Cancer Practitioner. Diseases of the Colon & Rectum 63(6):p 726-727, June 2020. | DOI: 10.1097/DCR.0000000000001688 [https://pubmed.ncbi.nlm.nih.gov/32479532/] Stal J, YI SY, Cohen-Cutler S, et al. Fertility Preservation Discussions Between Young Adult Rectal Cancer Survivors and Their Providers: Sex-Specific Prevalence and Correlates. Oncologist. 2022;27(7):579-586. doi:10.1093/oncolo/oyac052 [https://pubmed.ncbi.nlm.nih.gov/35708892/] Gentile G, Ciccarone M. Management of fertility preservation in young female patients with gastrointestinal cancer: A case series and systematic literature review. Curr Probl Cancer. 2025;57:101221. doi:10.1016/j.currproblcancer.2025.101221 [https://pubmed.ncbi.nlm.nih.gov/39598263/] Saif MW. Management of colorectal cancer in pregnancy: a multimodality approach. Clin Colorectal Cancer. 2005;5(4):247-256. doi:10.3816/ccc.2005.n.035 [https://pubmed.ncbi.nlm.nih.gov/16183863/] Rogers JE, Dasari A, Eng C. The Treatment of Colorectal Cancer During Pregnancy: Cytotoxic Chemotherapy and Targeted Therapy Challenges. Oncologist. 2016 May;21(5):563-70. doi: 10.1634/theoncologist.2015-0362. Epub 2016 Mar 21. PMID: 27000464; PMCID: PMC4861360. [https://pubmed.ncbi.nlm.nih.gov/27000464/] Jiang Q, Hua H. Fertility in young-onset colorectal patients with cancer: a review. Oncologist. 2024;29(10):e1237-e1245. doi:10.1093/oncolo/oyae141 [https://pubmed.ncbi.nlm.nih.gov/39292850/] Dolmans MM, Hollanders de Ouderaen S, Demylle D, Pirard C. Utilization rates and results of long-term embryo cryopreservation before gonadotoxic treatment. J Assist Reprod Genet. 2015;32(8):1233-1237. doi:10.1007/s10815-015-0533-z [https://pubmed.ncbi.nlm.nih.gov/26162569/ Moawad NS, Santamaria E, Rhoton-Vlasak A, Lightsey JL. Laparoscopic Ovarian Transposition Before Pelvic Cancer Treatment: Ovarian Function and Fertility Preservation. J Minim Invasive Gynecol. 2017;24(1):28-35. doi:10.1016/j.jmig.2016.08.831 [https://pubmed.ncbi.nlm.nih.gov/27599763/] Fish R. Ovarian transposition in rectal cancer: uncertain benefit at a high price. Colorectal Dis. 2022;24(6):706-707. doi:10.1111/codi.16086 [https://pubmed.ncbi.nlm.nih.gov/35191146/] Ribeiro R, Baiocchi G, Moretti-Marques R, Linhares JC, Costa CN, Pareja R. Uterine transposition for fertility and ovarian function preservation after radiotherapy. Int J Gynecol Cancer. 2023;33(12):1837-1842. Published 2023 Dec 4. doi:10.1136/ijgc-2023-004723 [https://pubmed.ncbi.nlm.nih.gov/38104863/] Haggar F, Pereira G, Preen D, et al. Maternal and neonatal outcomes in pregnancies following colorectal cancer. Surg Endosc. 2013;27(7):2327-2336. doi:10.1007/s00464-012-2774-6 [https://pubmed.ncbi.nlm.nih.gov/23645367/] Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.  If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listenBehind the Knife Premium: https://behindtheknife.org/premiumOral Board Review: https://behindtheknife.org/oral-boardOral Board Simulator: https://behindtheknife.org/oral-board/simulatorGeneral Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-reviewTrauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlasDominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkshipDominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotationVascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-reviewColorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-reviewSurgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-reviewCardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-reviewDownload our App:Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US

As people live longer, maintaining mental well-being has become an increasingly important part of healthy aging. While regular physical activity is known to support both physical and psychological health, many older adults face barriers that make traditional exercise programs difficult to sustain. Researchers have therefore been exploring new approaches that combine physical activity with enjoyment, social interaction, and cognitive engagement. A review published in Volume 18 of Aging titled “What are the effects of exergames on the mood states of older people? A systematic review of experimental studies, impacts on mental health and recommendations,” examined whether exergames—video games that require physical movement to play—can improve mood and mental health in older adults. The study was led by authors from the Laboratory of Sport and Exercise Psychology, Human Movement Sciences Graduate Program, College of Health and Sport Science of the Santa Catarina State University (UDESC) in Florianópolis, Brazil. Full blog - https://aging-us.org/2026/06/do-exergames-improve-mood-and-mental-well-being-in-older-adults/ DOI - https://doi.org/10.18632/aging.206361 Corresponding author - Alexandro Andrade - alexandro.andrade.phd@gmail.com Abstract video - https://www.youtube.com/watch?v=mNBh_alqVRI Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206361 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, electronic games, older adults, BRUMS, mental health, physical activity To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

In this episode of PICU Doc on Call, hosts Dr. Monica Gray and Dr. Pradip Kamat explore procedural sedation in the pediatric ICU. They cover sedation levels, pre-screening, risk stratification using ASA classifications, and medication selection tailored to each patient's hemodynamic and respiratory status. Through real-world case discussions involving respiratory failure, septic shock, and acute neurological decline, they highlight the importance of end-tidal CO2 monitoring and early adverse event recognition. Key takeaways include avoiding the term "conscious sedation," preparing rescue plans, and prioritizing patient safety through careful assessment and monitoring.Show Highlights:Definitions and levels of sedation (minimal, moderate, deep sedation, and general anesthesia)Importance of terminology in procedural sedationMonitoring sedation levels using scales like the Richmond Agitation-Sedation Scale (RASS)Pre-screening and risk stratification considerations for pediatric patientsASA physical status classification system for assessing patient riskUnique challenges of procedural sedation in critically ill childrenAdverse events associated with pediatric procedural sedation, particularly respiratory complicationsManagement strategies for specific cases requiring sedation (e.g., respiratory failure, septic shock)Importance of end-tidal CO2 monitoring during sedationKey takeaways for safe sedation practices in the pediatric ICU settingReferences: Nir Atlas; Rahul C. Damania; Pradip P. Kamat In Fuhrman & Zimmerman - Textbook of Pediatric Critical Care Chapter 135, 1624-1628Statement on Continuum of Depth of Sedation: Definition of General Anesthesia and Levels of Sedation/Analgesia by Committee on Quality Management and Departmental Administration. Last Amended: October 23, 2024.Coté CJ, Wilson S; AMERICAN ACADEMY OF PEDIATRICS; AMERICAN ACADEMY OF PEDIATRIC DENTISTRY. Guidelines for Monitoring and Management of Pediatric Patients Before, During, and After Sedation for Diagnostic and Therapeutic Procedures. Pediatrics. 2019 Jun;143(6):e20191000. doi: 10.1542/peds.2019-1000. PMID: 31138666.xKrauss B, Green SM. Procedural sedation and analgesia in children. Lancet. 2006 Mar 4;367(9512):766-80. doi: 10.1016/S0140-6736(06)68230-5. PMID: 16517277.Sharif S, Kang J, Sadeghirad B, Rizvi F, Forestell B, Greer A, Hewitt M, Fernando SM, Mehta S, Eltorki M, Siemieniuk R, Duffett M, Bhatt M, Burry L, Perry JJ, Petrosoniak A, Pandharipande P, Welsford M, Rochwerg B. Pharmacological agents for procedural sedation and analgesia in the emergency department and intensive care unit: a systematic review and network meta-analysis of randomised trials. Br J Anaesth. 2024 Mar;132(3):491-506. doi: 10.1016/j.bja.2023.11.050. Epub 2024 Jan 6. PMID: 38185564.Smith, Heidi A. B. MD, MSCI (Chair)1,2; Besunder, James B. DO, FCCM3,4; Betters, Kristina A. MD1; Johnson, Peter N. PharmD, BCPS, BCPPS, FCCM, FPPA, FASHP5,6; Srinivasan, Vijay MBBS, MD, FCCM7,8; Stormorken, Anne MD9,10; Farrington, Elizabeth PharmD, FCCM11; Golianu, Brenda MD12,13; Godshall, Aaron J. MD14; Acinelli, Larkin CPNP-AC, ACHPN15; Almgren, Christina CPNP16; Bailey, Christine H. MD17; Boyd, Jenny M. MD18,19; Cisco, Michael J. MD20; Damian, Mihaela MD, MPH21,22; deAlmeida, Mary L. MD23,24; Fehr, James MD13,25; Fenton, Kimberly E. MD, FCCM14; Gilliland, Frances DNP, CPNP-AC/PC26,27; Grant, Mary Jo C. CPNP-AC, PhD, FAAN28; Howell, Joy MD29; Ruggles, Cassandra A. PharmD, BCCCP, BCPPS30; Simone, Shari DNP31,32; Su, Felice MD21,22; Sullivan, Janice E. MD33,34; Tegtmeyer, Ken MD, FAAP, FCCM35,36; Traube, Chani MD, FCCM29; Williams, Stacey CPNP-AC37; Berkenbosch, John W. MD, FAAP, FCCM (Chair)33,34. 2022 Society of Critical Care Medicine Clinical Practice Guidelines on Prevention and Management of Pain, Agitation, Neuromuscular Blockade, and Delirium in Critically Ill Pediatric Patients With Consideration of the ICU Environment and Early Mobility. Pediatric Critical Care Medicine 23(2):p e74-e110, February 2022. | DOI: 10.1097/PCC.0000000000002873Benzoni T, Agarwal A, Cascella M. Procedural Sedation. [Updated 2025 Mar 22]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK551685/Kerson AG, DeMaria R, Mauer E, Joyce C, Gerber LM, Greenwald BM, Silver G, Traube C. Validity of the Richmond Agitation-Sedation Scale (RASS) in critically ill children. J Intensive Care. 2016 Oct 26;4:65. doi: 10.1186/s40560-016-0189-5. PMID: 27800163; PMCID: PMC5080705.Tel-Dan SF, Shavit D, Nates R, Samuel N, Shavit I. Emergency Physician-Administered Sedation for Thoracostomy in Children With Pleuropneumonia. Pediatr Emerg Care. 2021 Dec 1;37(12):e1209-e1212. doi: 10.1097/PEC.0000000000001975. PMID: 31929389.Cosgrove P, Krauss BS, Cravero JP, Fleegler EW. Predictors of Laryngospasm During 276,832 Episodes of Pediatric Procedural Sedation. Ann Emerg Med. 2022 Dec;80(6):485-496. doi: 10.1016/j.annemergmed.2022.05.002. Epub 2022 Jun 23. PMID: 35752522.Cravero JP, Blike GT, Beach M, Gallagher SM, Hertzog JH, Havidich JE, Gelman B; Pediatric Sedation Research Consortium. Incidence and nature of adverse events during pediatric sedation/anesthesia for procedures outside the operating room: report from the Pediatric Sedation Research Consortium. Pediatrics. 2006 Sep;118(3):1087-96. doi: 10.1542/peds.2006-0313. PMID: 16951002.

In dieser Vorlesung blende ich von der Ebene der satzwertigen Analyse auf Textebene, um Textprozeduren zu ermitteln und zu zeigen, wie und mit welchen sprachlichen Mitteln Erzählungen Räume öffnen und wie dies im Deutschunterricht genutzt werden kann. Anhand des authentischen Beispiels einer kindlichen Nacherzählung des Märchens "Schneewittchen" wird aufgezeigt, wie mittels temporaler und lokaler Adverbiale (Adverien und Präpositionalphrasen) Räumlichkeit und Figurenkonstellationen konstruiert und strukturiert werden können und der Verlauf einer Erzählung durch die Verkettung mentaler Räume gelingt, die im Beispiel als Orte, Areale und auch soziale Gemeinschaften durch Anordnung von Figuren zueinander in einer Geschichte zu beschreiben sind. Es wird am (authentischen) Beispiel demonstriert, wie Wortarten mithilfe generativer KI automatisiert ermittelt werden können, um interpretativ Adverbiale zu markieren. Darauf aufbauend werden computer- sowie korpuslinguistische Ansätze an Vergleichskorpora genutzt, um (inputoptimierte) sprachliche Mittel (z.B. Adverbien und adverial gebrauchte Präpostionalphrasen) für eine anschließende (prozedurorientierte) kreative Schreibphase der Schüler:innen zu identifizieren, die die Geschichte oder auch nur eine Szene adverbial erweitern.Präsentation (*.pdf): Alexander Lasch. 2026. Grammatik in der Schule. Zenodo. DOI: ⁠⁠⁠⁠https://doi.org/10.5281/zenodo.19236685⁠⁠⁠⁠. Videoaufzeichnungen: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://youtube.com/@AlexanderLasch⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Informationen & Material zu allen Vorlesungen: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://kurzelinks.de/fl7f⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Worksheet zu den Vorlesungen: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://kurzlinks.de/WorksheetVorlesungen⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Intro: "Reflections" von Scott Holmes (CC BY via ⁠⁠⁠⁠⁠⁠FMA⁠⁠⁠⁠⁠⁠).#Linguistik #OER #Sprache #Sprachwissenschaft #Grammatik #Konstruktionsgrammatik #Konstruktionsdikdatik

BUFFALO, NY — June 18, 2026 — A new #research paper was #published in Volume 18 of Aging on May 26, 2026, titled “Early-life determinants of cardiometabolic outcomes and accelerated biological ageing in Colombia.” The study was led by first and corresponding author Juan Carlos Rivillas from the Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, United Kingdom. Experiences during childhood can shape health for decades. Adverse childhood experiences (ACEs), such as emotional abuse, domestic violence, food insecurity, poor health, and forced displacement, have long been linked to chronic disease. However, less is known about how these early-life hardships may influence biological aging itself. In this study, researchers examined whether childhood adversity is associated with cardiometabolic disease and accelerated biological aging among older adults in Colombia. The investigators analyzed data from 3,385 adults aged 60 years and older who participated in the nationally representative SABE-Colombia study. Five forms of childhood adversity experienced before age 15 were evaluated: emotional abuse, domestic violence, poor childhood health, food scarcity, and forced migration related to Colombia's armed conflict. Biological aging was estimated using the Klemera-Doubal Method for Biological Age, a biomarker-based measure that compares biological age with chronological age. Full press release - https://aging-us.net/2026/06/18/childhood-adversity-may-leave-lasting-biological-scars-decades-later/ DOI - https://doi.org/10.18632/aging.206384 Corresponding author - Juan Carlos Rivillas - j.rivillas-garcia20@imperial.ac.uk Abstract video - https://www.youtube.com/watch?v=5w6vgFzjcNQ Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206384 Keywords - aging, adverse childhood experiences, forced childhood migration, biological ageing, cardiometabolic outcomes, life course epidemiology To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY – June 17, 2026 – A new #research paper was #published in Volume 17 of Oncotarget on June 8, 2026, titled “DHHC3 interferes with antitumor immunity in melanoma cells.” The study was led by first author and corresponding author Chandan Sharma and corresponding author Martin E. Hemler from the Department of Cancer Immunology and Virology at the Dana-Farber Cancer Institute. Melanoma is one of the most aggressive forms of skin cancer and is highly influenced by interactions between tumor cells and the immune system. Although modern immunotherapies have transformed treatment for many patients, researchers continue to search for molecular mechanisms that enable tumors to evade immune attack and continue growing. In this study, researchers investigated DHHC3, a protein acyltransferase that regulates protein palmitoylation and helps maintain cellular redox balance. Previous studies had linked elevated DHHC3 expression to poor outcomes in several cancers, but its role in melanoma and anti-tumor immunity remained unclear. To explore this question, the team used CRISPR gene editing to eliminate DHHC3 expression in B16F10 melanoma cells. Loss of DHHC3 caused a marked increase in oxidative stress and cellular senescence, as demonstrated by elevated TXNIP expression, increased reactive oxygen species levels, and enhanced expression of senescence-associated markers. Full press release - https://www.oncotarget.net/2026/06/17/protein-linked-to-melanoma-growth-may-suppress-the-bodys-natural-anti-tumor-immune-response/ DOI - https://doi.org/10.18632/oncotarget.28880 Correspondence to - Martin E. Hemler - martin_hemler@dfci.harvard.edu, and Chandan Sharma - csharma@mgh.harvard.edu Abstract video - https://www.youtube.com/watch?v=QQhP2VhzKSE Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28880 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, oxidative stress, DHHC3, anti-cancer immunity, palmitoylation, melanoma To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

In the library of a theological seminary, a researcher opens Eusebius's Church History and traces the bishops of Jerusalem - the mother church, the apostolic see of sees. He finds fifteen names spanning nearly two centuries. Marcus. Cassian. Publius. Maximus. Julian. Gaius. Symmachus. And eight more.No biographies. No letters. No sermons. No doctrines. No martyrdom accounts. Not a single quotation from their enemies. Fifteen bishops, two hundred years - and a perfect, surgical silence.Rome, Antioch, and Alexandria - churches that suffered the same persecutions - all preserved rich documentary traditions. Only Jerusalem is a vacuum. Not a damaged record. An erasure.This is Part 1 of "Sleight of Hand, Sleight of Scripture" - a documentary series from Pre-Nicene Perspective, hosted by Darren Kelama, based on the 2026 paper "The Myth of the Jerusalem Continuity" by Chancellor A.W. Mitchell (Journal of Pre-Nicene Christian Studies).In this episode, we walk the crime scene: Aelia Capitolina, the pagan colony Hadrian built on the rubble of Jerusalem in AD 135. Banned from the city on pain of death were not only Jews - but Jewish scriptures. Inside those walls, the only Christian canon that could legally exist was one without the Old Testament: the Evangelion and the Apostolikon. Hadrian, unwittingly, granted the unalloyed Pauline gospel a two-hundred-year sanctuary.And we meet the first ghost: Marcus, the first Gentile bishop of Aelia Capitolina, whom Mitchell identifies as the first Christian bishop in the Pauline sense - leader of a church whose Bible had no Torah, whose God was not Yahweh, whose throne was the mother church itself, and whose treasury held the accumulation of Paul's diaspora collection. ▶ PART 2 DROPS NEXT WEEK—————————⏱ CHAPTERS—————————0:00 — Cold Open: Fifteen Names, Fifteen Ghosts1:52 — The Question That Launched a 1,700-Year Cold Case2:20 — Welcome to Pre-Nicene Perspective (Series Intro)2:48 — Aelia Capitolina (AD 135)4:12 — Possessing the Septuagint Was a Capital Crime5:08 — The Only Christians Who Could Survive in Aelia6:04 — The Mitchell Thesis (2026 Paper)7:00 — Part III — The Red Herrings8:24 — Claim 1: "The Records Were Lost"9:48 — Claim 2: Irenaeus Never Quotes Them10:44 — Claim 3: "Jerusalem Was Always Yahwist"11:40 — Part IV — The Investigation Begins12:36 — The First Christian Bishop in the Pauline Sense13:04 — The Treasury of the Mother Church13:52 — The Apostolikon — Paul's War Report14:28 — Marcus Resolves to Act (Cliffhanger — Part 2 Next Week)—————————ACADEMIC SOURCES & FURTHER READING—————————

Prostate cancer is the most commonly diagnosed cancer among men and remains a leading cause of cancer-related death worldwide. While age, family history, and genetics are well-established risk factors, researchers have increasingly focused on the role of metabolic health in prostate cancer progression. Obesity, insulin resistance, type 2 diabetes, and chronic inflammation have all been associated with more aggressive disease, but the molecular mechanisms connecting these conditions to prostate cancer remain incompletely understood. A research paper titled “Epigenetic dysregulation and biological function of PDX1 in prostate cancer” was published in Volume 17 of Oncotarget. In this study, the researchers investigated whether a gene best known for regulating pancreatic function may also play an important role in prostate tumor biology. The study was led by first author Tayo A. Adeyika and corresponding author Bernard Kwabi-Addo from Howard University, Washington, DC. Full blog - https://www.oncotarget.org/2026/06/16/pdx1-may-link-metabolic-dysfunction-to-prostate-cancer-progression/ DOI - https://doi.org/10.18632/oncotarget.28854 Correspondence to - Bernard Kwabi-Addo - bkwabi-addo@howard.edu Abstract video - https://www.youtube.com/watch?v=itYVsyXJJoE Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28854 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, PDX1, DNA methylation prostate cancer, shRNA knockdown, over-expression, glucose To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Each month, we will highlight a paper published in Aging chosen as the “Editors' Choice.” These selections are handpicked by our editors and accompanied by a brief summary, showcasing research with significant impact and novel insights in aging and age-related diseases. This exploratory randomized controlled trial, titled “Short-term responsiveness of DNA methylation–based aging biomarkers to a multimodal intervention comprising exercise and dietary guidance involving daily consumption of yogurt containing Bifidobacterium longum BB536: an exploratory randomized controlled trial,” investigated whether a 12-week lifestyle intervention combining exercise, dietary guidance, and daily consumption of yogurt containing Bifidobacterium longum BB536 could influence biological aging. The researchers found a significant slowing of the DNA methylation-based pace of aging measure DunedinPACE in overweight men aged 50 and older, suggesting that feasible lifestyle changes may be associated with short-term improvements in selected epigenetic aging biomarkers. DOI - https://doi.org/10.18632/aging.206386 Corresponding author - Yukihiro Hishida - yukihiro-hishida639@morinagamilk.co.jp Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206386 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, DNA methylation clock, DunedinPACE, Multicomponent lifestyle intervention, Bifidobacterium longum BB536 To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY — June 16, 2026 — A new #research paper was #published in Volume 18 of Aging on May 22, 2026, titled “Systemic cancer risk profile in neovascular age-related macular degeneration: insights into shared aging-related mechanisms from a nationwide population-based study.” The study was led by first author Hyeong Min Kim and corresponding author Hyewon Chung from Konkuk University College of Medicine and Konkuk University Medical Center in Seoul, Republic of Korea. Neovascular age-related macular degeneration (nAMD) is one of the leading causes of severe vision loss in older adults. Although the disease primarily affects the retina, researchers increasingly recognize that it may reflect broader biological processes associated with aging, including chronic inflammation, vascular dysfunction, and immune dysregulation. These same mechanisms have also been implicated in the development of several cancers, raising questions about whether the two conditions may be biologically connected. To explore this possibility, investigators analyzed data from the Korean National Health Insurance Service, one of the world's largest population-based healthcare databases. The study included 334,091 individuals aged 50 years and older, including 83,742 patients with nAMD and 250,349 matched controls without the disease. Participants were followed for up to 10 years, allowing researchers to evaluate both overall cancer incidence and risks for specific cancer types. The analysis revealed that individuals with nAMD had a modest but statistically significant increase in overall cancer risk compared with matched controls. However, the increased risk was not observed across all cancers. Instead, patients with nAMD showed elevated risks for several specific malignancies, including thyroid, kidney, pancreatic, lung, bladder, and prostate cancers, while no significant associations were found for many other cancer types. Full press release - https://aging-us.net/2026/06/16/common-aging-mechanisms-may-link-vision-loss-disorder-to-increased-risk-of-certain-cancers/ DOI - https://doi.org/10.18632/aging.206383 Corresponding author - Hyewon Chung - hchung@kuh.ac.kr Abstract video - https://www.youtube.com/watch?v=hViOqGLYr1Y Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206383 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, neovascular age-related macular degeneration, cancer, population cohort, polygenic risk, shared susceptibility To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

The early modern period was a rocky time for religion across Europe, fundamental pinnings of everyday life were being questioned and changing, as the reformation shifted authority away from the church. Thoughts on death and the afterlife were turned upside down, and in villages across England, restless spirits were making a comeback. To confront these supernatural intruders, communities turned to their local clergy to carry out the practice of ghost-laying, an exorcism ritual that sought to bind and banish the dead. At least, that's what Victorian authors would have liked to believe. Part religion, part folklore, and part fear, the subject of ghost-laying is fairly well complicated, and defining just how much of it is actually true, even more so. SOURCES Walsh, Brendan C. (2023) ‘He Could Raise and Lay Ghosts at His Will': Victorian Folklorists and the Creation of Early Modern Clerical Ghost-Laying. Folklore, 134:3, 281-303, DOI: 10.1080/0015587X.2023.2187157 Bottrell, William (1870) Traditions & Hearthside Stories of West Cornwall. Beare & Son, Penzance, UK. Hawker, Robert Steven (1870) Footprints of Former Men in Far Cornwall. James C. Commin, Exeter, UK. Andrews, William (1898) The Church Treasury of History, Custom, Folk-Lore, etc. London, UK. Bond, Thomas (1823) Topographical and Historical Sketches of the Boroughs of East and West Looe, in the County of Cornwall. J. Nichols & Son, London, UK. Hunt, Robert (1865) Popular Romances of the West of England, Or, The Drolls, Traditions and Superstitions of Old Cornwall. John Camden Hotten, London, UK. Courtney, Margaret Anne (1973) Cornish Feasts & Folklore. EP Publishing Ltd. UK. ------ For almost anything, head over to the podcasts hub at ⁠⁠⁠⁠⁠⁠⁠darkhistories.com ⁠⁠⁠⁠⁠⁠⁠ Support the show by visiting our Patreon for bonus episodes and Early Access: ⁠⁠⁠⁠⁠⁠⁠https://www.patreon.com/darkhistories⁠⁠⁠⁠⁠⁠⁠ The Dark Histories books are available to buy here: ⁠⁠⁠⁠⁠⁠⁠http://author.to/darkhistories⁠⁠⁠⁠⁠⁠⁠ Dark Histories merch is available here: ⁠⁠⁠⁠⁠⁠⁠https://bit.ly/3GChjk9⁠⁠⁠⁠⁠⁠⁠ Connect with us on Facebook: ⁠⁠⁠⁠⁠⁠⁠http://facebook.com/darkhistoriespodcast⁠⁠⁠⁠⁠⁠⁠ Or find us on Twitter: ⁠⁠⁠⁠⁠⁠⁠http://twitter.com/darkhistories⁠⁠⁠⁠⁠⁠⁠ & Instagram: ⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/dark_histories/⁠⁠⁠⁠⁠⁠⁠ Or you can contact us directly via email at ⁠⁠⁠⁠⁠⁠⁠contact@darkhistories.com⁠⁠⁠⁠⁠⁠⁠ or join our Discord community: ⁠⁠⁠⁠⁠⁠⁠https://discord.gg/cmGcBFf⁠⁠⁠⁠⁠⁠⁠ The Dark Histories Butterfly was drawn by Courtney, who you can find on Instagram @bewildereye Music was recorded by me © Ben Cutmore 2017 Other Outro music was Paul Whiteman & his orchestra with Mildred Bailey - All of me (1931). It's out of copyright now, but if you're interested, that was that. Learn more about your ad choices. Visit megaphone.fm/adchoices

BUFFALO, NY – June 15, 2026 – A new #research paper was #published in Volume 17 of Oncotarget on June 5, 2026, titled “A randomized double-blind placebo-controlled phase I/II clinical trial of a human papillomavirus therapeutic vaccine, PepCan, for reducing head and neck squamous cell carcinoma recurrence.” The study was led by first author Emily Bivens and corresponding author Mayumi Nakagawa from the University of Arkansas for Medical Sciences, Little Rock. Head and neck squamous cell carcinoma (HNSCC) remains a major clinical challenge. Even after surgery, radiation, and chemotherapy successfully eliminate detectable disease, many patients experience recurrence within the following years. Researchers have therefore been exploring whether immunotherapy-based approaches can help strengthen anti-tumor immune responses and reduce the risk of cancer returning. In this study, investigators evaluated PepCan, an experimental therapeutic vaccine designed to stimulate immune responses against human papillomavirus type 16 (HPV 16). Unlike preventive HPV vaccines that aim to stop infection before it occurs, therapeutic vaccines are intended to activate the immune system against existing HPV-related disease. PepCan contains four HPV 16 E6 peptides combined with a Candida-derived immune-stimulating adjuvant. Full press release - https://www.oncotarget.net/2026/06/15/hpv-therapeutic-vaccine-shows-safety-but-uncertain-benefit-in-preventing-head-and-neck-cancer-recurrence/ DOI - https://doi.org/10.18632/oncotarget.28892 Correspondence to - Mayumi Nakagawa - mnakagawa@uams.edu Abstract video - https://www.youtube.com/watch?v=oh0MNrrPGhw Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28892 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, human papillomavirus, head and neck cancer, therapeutic vaccine, adjuvant, clinical trial To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us on social media: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

This week we go back 2.5 years and delve into the world of cardiovascular surgery when we review a review of STS data on the pulmonary artery band (PAB). The STS assigns a STAT category of 4 to this operation, denoting higher risk for mortality. Is this warranted? Are all PAB candidates equal? What features are associated with higher or lower mortality rates in patients undergoing banding? Should the data in this work drive innovation to avoid the PAB in some settings? These are amongst the questions posed to the senior author of this week's work, cardiovascular surgeon Dr. Tara Karamlou who is Professor of Surgery at the Cleveland Clinic in Cleveland, Ohio. DOI: 10.1016/j.athoracsur.2023.09.020

If you enjoy this episode, we're sure you will enjoy more content like this on The Occult Rejects.  In fact, we have curated playlists on occult topics like grimoires, esoteric concepts and phenomena, occult history, analyzing true crime and cults with an occult lens, Para politics, and occultism in music. Whether you enjoy consuming your content visually or via audio, we've got you covered - and it will always be provided free of charge.  So, if you enjoy what we do and want to support our work of providing accessible, free content on various platforms, please consider making a donation to the links provided below.  Thank you and enjoy the episode!Links For The Occult Rejectshttps://linktr.ee/theoccultrejectsOccult Research Institutehttps://www.occultresearchinstitute.org/Substackhttps://substack.com/@theoccultrejects?r=7auau0&utm_campaign=profile&utm_medium=profile-pageCash Apphttps://cash.app/$theoccultrejectsVenmo@TheOccultRejectsBuy Me A Coffeebuymeacoffee.com/TheOccultRejectsPatreonhttps://www.patreon.com/TheOccultRejectsBibliographyAelian. On the Characteristics of Animals. Translated by A. F. Scholfield. Loeb Classical Library. Cambridge, MA: Harvard University Press, 1958–1959.Assmann, Jan. The Search for God in Ancient Egypt. Translated by David Lorton. Ithaca: Cornell University Press, 2001.British Museum. “Papyrus of Nesmin; Bremner-Rhind Papyrus, EA10188.” Notes that the Book of Overthrowing Apep appears in columns 22–32, with the Names of Apep in columns 32–33, and gives a production date of 305 BCE.British Museum. Babylon Teachers' Resource. Notes Marduk's association with the snake-dragon or mušḫuššu.Burkert, Walter. Greek Religion. Translated by John Raffan. Cambridge, MA: Harvard University Press, 1985.Day, John. God's Conflict with the Dragon and the Sea: Echoes of a Canaanite Myth in the Old Testament. Cambridge: Cambridge University Press, 1985.Detroit Institute of Arts. “Mushhushshu-Dragon, Symbol of the God Marduk.”Eliade, Mircea. Patterns in Comparative Religion. Translated by Rosemary Sheed. Lincoln: University of Nebraska Press, 1996.Etymonline. “Draco.” Notes Greek drakon from derkesthai, “to see clearly.”Faulkner, R. O. “The Bremner-Rhind Papyrus—III: D. The Book of Overthrowing ‘Apep.” Journal of Egyptian Archaeology 23, no. 2 (1937): 166–185.Ferdowsi. Shahnameh: The Persian Book of Kings. Translated by Dick Davis. New York: Penguin Classics, 2016.Herodotus. The Histories. Translated by A. D. Godley. Loeb Classical Library. Cambridge, MA: Harvard University Press, 1920. See especially 2.75 on winged serpents and ibises, and 3.107 on frankincense-guarding serpents.Hornung, Erik. Conceptions of God in Ancient Egypt: The One and the Many. Translated by John Baines. Ithaca: Cornell University Press, 1982.Isbell, Lynne A. The Fruit, the Tree, and the Serpent: Why We See So Well. Cambridge, MA: Harvard University Press, 2009.Jacobus de Voragine. The Golden Legend: Readings on the Saints. Translated by William Granger Ryan. Princeton: Princeton University Press, 2012.Jones, David E. An Instinct for Dragons. New York: Routledge, 2000.Le, Quan Van, Lynne A. Isbell, Jumpei Matsumoto, Minh Nguyen, Hikari Hori, Mai Mai, Tomohiro Nishimaru, et al. “Pulvinar Neurons Reveal Neurobiological Evidence of Past Selection for Rapid Detection of Snakes.” Proceedings of the National Academy of Sciences 110, no. 47 (2013): 19000–19005. DOI: 10.1073/pnas.1312648110.LeDoux, Joseph. The Emotional Brain: The Mysterious Underpinnings of Emotional Life. New York: Simon & Schuster, 1996.Lincoln, Bruce. Theorizing Myth: Narrative, Ideology, and Scholarship. Chicago: University of Chicago Press, 1999.MacLean, Paul D. The Triune Brain in Evolution: Role in Paleocerebral Functions. New York: Plenum Press, 1990.Mayor, Adrienne. The First Fossil Hunters: Dinosaurs, Mammoths, and Myth in Greek and Roman Times. Princeton: Princeton University Press, 2000; revised edition, 2011.Öhman, Arne, and Susan Mineka. “Fears, Phobias, and Preparedness: Toward an Evolved Module of Fear and Fear Learning.” Psychological Review 108, no. 3 (2001): 483–522.Pessoa, Luiz. The Cognitive-Emotional Brain: From Interactions to Integration. Cambridge, MA: MIT Press, 2013.Pliny the Elder. Natural History. Translated by H. Rackham. Loeb Classical Library. Cambridge, MA: Harvard University Press, 1938–1962.Smith, Mark S. The Ugaritic Baal Cycle. 2 vols. Leiden: Brill, 1994–2009.Smith, Mark S. The Origins of Biblical Monotheism: Israel's Polytheistic Background and the Ugaritic Texts. Oxford: Oxford University Press, 2001.Varenne, Jean, trans. The Rig Veda. New York: Park Street Press, 1984.Yarshater, Ehsan, ed. “Aždahā.” Encyclopaedia Iranica. Defines aždahā as dragon-like, gigantic snake monsters found in air, earth, or sea, sometimes linked to rain and eclipses.Also want to remind people about the website, if you're into reading we have tons of information by multiple contributors, and we got t-shirts up on the site if you're interested. Fun fact, the art is all based on the eyeball. A

Join the Behind the Knife Surgical Oncology Team as we discuss clinical challenges through case-based examples including the diagnosis, workup, and management of patients with cutaneous melanoma. Learning Objectives:In this episode, we review the workup and management of patients with cutaneous melanoma and both microscopic and macroscopic nodal disease. References used in the making of this episode: Reijers, I.L.M., Menzies, A.M., van Akkooi, A.C.J. et al. Personalized response-directed surgery and adjuvant therapy after neoadjuvant ipilimumab and nivolumab in high-risk stage III melanoma: the PRADO trial. Nat Med 28, 1178–1188 (2022). https://doi.org/10.1038/s41591-022-01851-x Christian U. Blank et al. Neoadjuvant nivolumab plus ipilimumab versus adjuvant nivolumab in macroscopic, resectable stage III melanoma: The phase 3 NADINA trial.. J Clin Oncol 42, LBA2-LBA2(2024). DOI:10.1200/JCO.2024.42.17_suppl.LBA2 Faries MB, Thompson JF, Cochran AJ, et al. Completion Dissection or Observation for Sentinel-Node Metastasis in Melanoma. N Engl J Med. 2017;376(23):2211-2222. doi:10.1056/NEJMoa1613210   https://pubmed.ncbi.nlm.nih.gov/28591523/ National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Cutaneous Melanoma. Version 1.2026. Accessed April 8, 2026. NCCN Guidelines PDF   Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.  If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listenBehind the Knife Premium: https://behindtheknife.org/premiumOral Board Review: https://behindtheknife.org/oral-boardOral Board Simulator: https://behindtheknife.org/oral-board/simulatorGeneral Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-reviewTrauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlasDominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkshipDominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotationVascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-reviewColorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-reviewSurgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-reviewCardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-reviewDownload our App:Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US

BUFFALO, NY — June 11, 2026 — A new #meetingreport was #published in Volume 18 of Aging on May 14, 2026, titled “Foundations of Gerophysics.” The report was led by corresponding authors Maximilian Unfried and Brian K. Kennedy from the National University of Singapore. Aging is often studied through biology, genetics, and medicine. Yet despite tremendous advances, many fundamental questions remain unanswered: Why do organisms age at different rates? Why does resilience decline over time? And can the trajectory of aging be predicted before disease develops? Researchers participating in the inaugural Global Conference on Gerophysics explored whether answering these questions may require integrating biology with the quantitative principles of physics. Held in Singapore on March 5–6, 2025, the conference brought together 160 researchers from physics, biology, computation, and medicine and featured 31 speakers from institutions around the world. The meeting focused on developing a predictive and testable science of aging by applying concepts from dynamical systems, thermodynamics, network theory, stochastic processes, and artificial intelligence to biological aging. Full press release - https://aging-us.net/2026/06/11/physics-meets-aging-researchers-lay-the-foundations-of-gerophysics/ DOI - https://doi.org/10.18632/aging.206378 Corresponding authors - Maximilian Unfried - unfried@nus.edu.sg, and Brian K. Kennedy - bkennedy@nus.edu.sg Abstract video - https://www.youtube.com/watch?v=hgsA8EhjF0U Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206378 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - gerophysics, geroscience, aging biology, longevity, complex systems, theoretical physics To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY — June 10, 2026 — A new #research paper was #published in Volume 18 of Aging on May 18, 2026, titled “Transcriptional programs diverge in aging mouse and human skeletal muscle.” The study was led by co-first authors Charles D. Hwang and Siti Rahmayanti and corresponding author Indranil Sinha from Brigham and Women's Hospital, Harvard University. Aging is widely associated with the gradual loss of muscle mass, strength, and physical function. Much of what scientists know about these changes comes from studies in laboratory mice, which are frequently used to investigate the biological mechanisms of aging and to identify potential therapeutic targets. However, an important question remains: how closely do aging-related changes in mouse muscle reflect what actually occurs in humans? To address this question, researchers performed a detailed comparison of gene expression patterns in skeletal muscle from young and old mice and humans. The team analyzed RNA sequencing data from mouse gastrocnemius muscle and compared it with transcriptomic data from healthy young and older adults obtained through the National Institute on Aging's GESTALT study. The results revealed substantial differences between the two species. Despite both mice and humans experiencing age-related muscle decline, fewer than 5% of significantly altered biological pathways were shared between them. Many of the genetic programs that changed with aging in mice showed little resemblance to those observed in human skeletal muscle. Full press release - https://aging-us.net/2026/06/10/aging-muscle-follows-different-genetic-programs-in-mice-and-humans/ DOI - https://doi.org/10.18632/aging.206382 Corresponding author - Indranil Sinha - isinha@bwh.harvard.edu Abstract video - https://www.youtube.com/watch?v=CYKh4X1w8H0 Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206382 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - hypoxia, angiogenesis, aging, skeletal muscle, regeneration To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

References eLife 2020;9:e55828 DOI:10.7554/eLife.55828Cell Death Discovery2024.  10, Article number: 231 Int J Mol Sci. 2017 Sep 15;18(9):1979Guerra, DJ.2026. Unpublished lecturesHunter/Lesh 1970. Box of Rainhttps://open.spotify.com/track/7x2xjJV3YAPeLQJ7u3Kjet?si=37646e5c42584619

Why do some people appear to age faster than others, even when they are the same age? Researchers increasingly believe that chronological age tells only part of the story. Biological age attempts to capture how well the body's systems are functioning and may provide a more meaningful picture of overall health. A research paper on this topic was published in Volume 18 of Aging titled “Blood biochemical and gut microbiotic neural network models forecasting human biological age.” In the study, Russian researchers explored whether information from routine blood tests and the gut microbiome could be used to estimate biological age. Full blog - https://aging-us.org/2026/06/blood-tests-and-gut-bacteria-may-help-reveal-your-biological-age/ DOI - https://doi.org/10.18632/aging.206360 Corresponding author - Alexey Moskalev - amoskalev@med.ru Abstract video - https://www.youtube.com/watch?v=wg3YEwXMKWY Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206360 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, biological age, blood biochemistry, gut microbiome, neural network To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

¿Qué posibilidades se abren con el nuevo Espacio Europeo de Datos de Salud? ¿Se atisba la promesa de otros espacios similares? ¿Hasta dónde llegan los usos secundarios de los datos de salud? ¿Qué hacemos con los “wearables”? ¿Dónde terminan las garantías individuales y empieza el beneficio colectivo en el ámbito de la investigación?Mikel Recuero es Doctor en Derecho por la Universidad del País Vasco. Es investigador postdoctoral en la Red de Derecho y Genoma Humano, donde ejerce como experto en asuntos legales, éticos y regulatorios (ELSI) para distintos proyectos nacionales y europeos. Su campo de estudio se centra en las intersecciones entre derecho, ética, ciencia y tecnología. Actividad que compatibiliza con el ejercicio de funciones de consultoría en materia de protección de datos y data governance y con la docencia en varias universidades españolas. Es también miembro del Órgano de Gobierno del Código de Conducta de Protección de Datos de FARMAINDUSTRIA. También es autor de una veintena de publicaciones en revistas científicas y académicas especializadas, ha recibido el Premio de Investigación en Protección de Datos por la Autoridad Vasca de Protección de Datos (AVPD/DBEA) en el año 2024 y el Accésit del Premio de Investigación en Protección de Datos Personales Emilio Aced por la Agencia Española de Protección de Datos (AEPD) en el año 2019.Referencias:* Mikel Recuero en LinkedIn* AA.VV. El Espacio Europeo de Datos de Salud y su implementación en España. Fundación Roche, 2026.* Comité de Bioética de España. Informe sobre aspectos del uso secundario de los datos y el Espacio Europeo de Datos de Salud. 2023.* European Commission. Frequently Asked Questions on the European Health Data Space. Last updated 26th March 2026. Disponible en:* Recuero, Mikel. «El uso secundario de datos de salud electrónicos: el futuro Reglamento del Espacio Europeo de Datos de Salud y su interacción con la protección de datos personales». InDret 2 (2024): 525-51. DOI: 10.31009/InDret.2024.i2.13* Reglamento (UE) 2025/327 del Parlamento Europeo y del Consejo, de 11 de febrero de 2025, relativo al Espacio Europeo de Datos de Salud, y por el que se modifican la Directiva 2011/24/UE y el Reglamento (UE) 2024/2847. «DOUE» núm. 327, de 5 de marzo de 2025, páginas 1 a 96 (96 págs.)* Patricia Muleiro: la gestión de los datos de salud en escenarios complejos (Masters of Privacy, marzo de 2023). This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.mastersofprivacy.com/subscribe

In the ACOG PB 231, Multifetal Gestations Twin Triplet and Higher-Order Multifetal Pregnancies, it states, “based on the improved outcomes reported in singleton gestations, the National Institutes of Health recommends that, unless a contraindication exists, a course of antenatal corticosteroids should be administered to all patients who are at risk of delivery within 7 days and who are between 24 weeks and 34 weeks of gestation, irrespective of the fetal number”. But a BRAND NEW meta-analysis is saying the exact opposite- with a catch. Listen in for details.1. ACOG PB 2312. Felippe, Carolina Alves MS; Ruiz, Sinrraim dos Santos Chaves MD; de Souza, Rebeca Ferreira MS; de Lima, Aliny Silva MS; dos Santos, Priscila Luiza MS; Fonseca, Pandora Eloa Oliveira MS; de Almeida Silva, Ingryd MS; Montes-de-Oca-Saucedo, Carlos Roberto MD; Santana, Ana Cecília Oliveira MS; Veta Darkovski, Jasmina MD; Matlaw, Hadas Rachel MD; Fonseca Queiroz, Laura MD. Antenatal Corticosteroid Use in Twin Pregnancies: A Systematic Review and Meta-analysis. Obstetrics & Gynecology ():10.1097/AOG.0000000000006344, June 4, 2026. | DOI: 10.1097/AOG.000000000000634416% OFF TONA ACTIVE WEAR PROMO: https://tonaactive.com/discount/CHAPANOSPINOBG

BUFFALO, NY – June 8, 2026 – A new #research paper was #published in Volume 17 of Oncotarget on June 3, 2026, titled “The anticancer effects of PCAIs in pancreatic cancer cells involve MAPK and PI3K/AKT pathways hyperactivation.” The study was led by first author Kweku Ofosu-Asante and corresponding author Nazarius S. Lamango from the Florida A&M University College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health in Tallahassee, Florida. Pancreatic ductal adenocarcinoma is among the deadliest forms of cancer, due in large part to the high frequency of KRAS mutations that drive tumor growth and resistance to treatment. Although targeted therapies have recently been developed for specific KRAS mutations, many patients continue to have limited treatment options, highlighting the need for broader strategies capable of targeting multiple KRAS-driven cancers. In this study, researchers investigated a class of experimental compounds known as polyisoprenylated cysteinyl amide inhibitors (PCAIs), which were originally designed to disrupt abnormal KRAS signaling. Using pancreatic cancer cell lines carrying KRAS mutations, the team explored how these compounds affect cancer cell survival, migration, invasion, and the molecular pathways that regulate tumor growth. Full press release - https://www.oncotarget.com/news/pr/experimental-compounds-trigger-cancer-cell-death-in-kras-driven-pancreatic-cancer/ DOI - https://doi.org/10.18632/oncotarget.28879 Correspondence to - Nazarius S. Lamango - nazarius.lamango@famu.edu Abstract video - https://www.youtube.com/watch?v=asbhjME7rFQ Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28879 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, PCAIs, PDAC, MAPK, PI3K/AKT, KRAS To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us on social media: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

ReferenceseLife 2020;9:e55828 DOI:10.7554/eLife.55828 Int J Mol Sci 2017 Sep 15;18(9):1979 Genes (Basel) 2021 Aug 31;12(9):1370Guerra, DJ.2026. Unpublished LecturesDylan, B. 1964. My Back Pages. Byrdshttps://open.spotify.com/track/1yexhSDARSLVvRCBU3wDAm?si=56d728e0cdcd42a4Winwood/Capaldi, 1970. Empty Pages. Traffichttps://open.spotify.com/track/4UhB17vQsTP0qM9grc4ZUi?si=636948e5ac7f457eSeger,B. 1972. Turn the Page.https://open.spotify.com/track/3P2XAL8UpPBM3nfvuEjHHE?si=47130e77f3ae4729

In this bonus episode of Communicable, hosts Anne-Grete Märtson and Angela Huttner invite Martin Grobush (University of Amsterdam; ESCMID Emerging Infections Subcommittee) and Daniel Bausch (National University of Singapore, London School of Hygiene & Tropical Medicine, and Geneva Graduate Institute) to discuss the Bundibugyo ebolavirus outbreak currently ongoing in the Democratic Republic of Congo and Uganda. Clinical and virological differences between Bundibugyo and Zaire ebolaviruses are discussed, as are the particular challenges for diagnosis, treatment, and prevention confronting healthcare workers of this outbreak. The episode accompanies two new publications in CMI Communications and CMI:Gupta N, Mora-Rillo M, Gkrania-Klotsas E, et al. Bundibugyo ebolavirus (BDBV): what first responders/clinicians need to know. CMI Communications, 2026; 2 (DOI: 10.1016/j.cmicom.2026.105207) Gupta N, Marta Mora-Rillo, Gkrania-Klotsas E, et al. Bundibugyo ebolavirus outbreak in the Democratic Republic of the Congo and Uganda: rapid assessment from the ESCMID Emerging Infections Subcommittee. Clin Microbiol Infect, 2026 (DOI: 10.1016/j.cmi.2026.05.042)

Jacqueline M. Kruser, MD, joins CHEST® Journal Podcast Moderator Matt Siuba, DO, MS, to discuss her research into the extent to which ICU care delivery is associated with patient priorities as reported in real time by their surrogate decision-makers.  DOI: 10.1016/j.chest.2026.01.028 Disclaimer: The purpose of this activity is to expand the reach of CHEST content through awareness, critique, and discussion. All articles have undergone peer review for methodologic rigor and audience relevance. Any views asserted are those of the speakers and are not endorsed by CHEST. Listeners should be aware that speakers' opinions may vary and are advised to read the full corresponding journal article(s) for complete context. This content should not be used as a basis for medical advice or treatment, nor should it substitute the judgment used by clinicians in the practice of evidence-based medicine. 

BUFFALO, NY — June 5, 2026 — A new #review was #published in Volume 18 of Aging on May 15, 2026, titled “Blue period – features of senescence 30 years after beta-galactosidase.” The review was led by first author Chisaka Kuehnemann and corresponding author Christopher D. Wiley from Tufts University. Cellular senescence has emerged as one of the most important biological processes linked to aging and age-related disease. Senescent cells stop dividing in response to stress or damage, yet they remain metabolically active and release a variety of signaling molecules that can influence surrounding tissues. Over the past three decades, evidence has increasingly shown that the accumulation of these cells contributes to chronic inflammation, tissue dysfunction, and many degenerative conditions associated with aging. In this review, the authors examine how the field has evolved since the landmark discovery of senescence-associated beta-galactosidase (SA-β-gal) in 1995. That finding provided one of the first practical methods for identifying senescent cells and helped establish that these cells accumulate in aging tissues. Since then, researchers have identified numerous additional characteristics of senescence and developed new approaches to study their role in health and disease. The review highlights several major features now recognized as hallmarks of senescent cells. These include stable proliferative arrest, increased lysosomal activity, secretion of inflammatory and signaling molecules collectively known as the senescence-associated secretory phenotype (SASP), mitochondrial dysfunction, alterations in nuclear architecture, accumulation of metals and lipofuscin, and enhanced survival despite exposure to cellular stress. Full press release - https://aging-us.net/2026/06/05/thirty-years-after-the-discovery-of-sa-%ce%b2-gal-researchers-revisit-the-hallmarks-of-cellular-senescence/ DOI - https://doi.org/10.18632/aging.206380 Corresponding author - Christopher D. Wiley - christopher.wiley@tufts.edu Abstract video - https://www.youtube.com/watch?v=lfMPJF6No7M Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206380 Keywords - aging, senescence, biomarkers, SASP, cell death To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

上週去日本經過五篇文章提供參考Influence of topical menthol gel on thermoregulation and perception while walking in the heat (Rosales et al., 2024)DOI: 10.1007/s00421-023-05279-0A Mixed-Method Approach of Pre-Cooling Enhances High-Intensity Running Performance in the Heat (Xu et al., 2021)DOI: 10.52082/jssm.2021.26Effects of cutaneous administration of an over-the-counter menthol cream during temperate-water immersion for exercise-induced hyperthermia in men (Wang & Hurr, 2023)DOI: 10.3389/fphys.2023.1161240The Effects of Palm Cooling on Repeat Sprint Ability Following a Fatigue Inducing Protocol in Collegiate Female Athletes (Wrabley et al., 2025)DOI: 10.70252/KSSI2281Thermal and Biomechanical Responses of Amateur, Elite and World Cup Athletes During a World Cup Sprint Triathlon in the Heat (James et al., 2025)DOI: 10.1007/s40279-025-02193-7騎慢一點：空腹喝水+益生菌+芝麻粉贊助方案每月訂閱贊助-51元。 https://p.ecpay.com.tw/D5BEE2F單筆收聽贊助-不限金額 https://p.ecpay.com.tw/B9C572A互動方式LINE@ 官方帳號，好友欄搜尋： @350esafo志祥instagram https://www.instagram.com/olinexo99/志祥臉書粉絲專頁 https://www.facebook.com/TaiwanTriathleteYang/ Powered by Firstory Hosting

The research gets real today! Join Jenny and John as they reunite for the first time in 2026 to discuss coffee, supplements, aging and longevity, the evolution of health across the lifespan and more! References: Ryan Yan Liu, Enwu Liu. Longitudinal Association of Coffee and Tea Consumption with Bone Mineral Density in Older Women: A 10-Year Repeated-Measures Analysis in the Study of Osteoporotic Fractures. Nutrients, 2025; 17 (23): 3660 DOI: 10.3390/nu17233660Felipe Leoratto Parizoto, Elisangela Dos Santos, Natália de Matos Balsalobre, Caren Naomi Aguero Ito, Flávia Barbieri Bacha, Luis Fernando Benitez Macorini, Marcos Jose Salvador, Arielle Cristina Arena, Cândida Aparecida Leite Kassuya. Ethanolic extract of Alternanthera littoralis P. Beauv. aerial parts: Safety assessment and efficacy in experimental models of articular. Journal of Ethnopharmacology, 2026; 355: 120720 DOI: 10.1016/j.jep.2025.120720Keenan S. Pearson, Sarah K. Jachim, Caroline D. Doherty, Brandon A. Wilbanks, Luis I. Prieto, Maria Dugan, Darren J. Baker, Nathan K. LeBrasseur, L. James Maher. An Unbiased Cell‐Culture Selection Yields DNA Aptamers as Novel Senescent Cell‐Specific Reagents. Aging Cell, 2025; 24 (11) DOI: 10.1111/acel.70245

Albina Tyker, MD, and Kerri A. Johannson, MD, MPH, join CHEST® Journal Podcast Moderator Alice Gallo De Moraes, MD, FCCP, to discuss their research into the association between recovery time from exertional desaturation following a 6-minute walk test with disease severity and progression in patients with fibrotic interstitial lung disease. DOI: 10.1016/j.chest.2025.12.023 Disclaimer: The purpose of this activity is to expand the reach of CHEST content through awareness, critique, and discussion. All articles have undergone peer review for methodologic rigor and audience relevance. Any views asserted are those of the speakers and are not endorsed by CHEST. Listeners should be aware that speakers' opinions may vary and are advised to read the full corresponding journal article(s) for complete context. This content should not be used as a basis for medical advice or treatment, nor should it substitute the judgment used by clinicians in the practice of evidence-based medicine.  

Loneliness can cost you up to 20 years of healthy life. More than poor sleep. More than any supplement. And until now, there was no way to measure it.Dr. Axel Schumacher spent 25 years at the forefront of genomics and epigenetic clock research and says your social life is a more powerful longevity biomarker than anything in your bloodwork. In this episode, he walks through the Social Connectivity Value (SCV): a framework he developed to map your social network, identify the relationships that drain your energy, and turn your social health into a number you can actually track. What you'll learn:* Why loneliness can cost 12–20 years of healthy life (men are hit harder than women) and why the “smoking 15 cigarettes a day” statistic doesn't change behavior without a way to measure it* How to build a sociogram using Dunbar's three layers, assign energy values to every person in your life (including the ones dragging you down), and calculate your SCV score* Why looking for a romantic partner through your close friends almost never works, and the “super connector” strategy that statistically gives you access to 150 new people from a single introductionWhat's the link between loneliness, AI companions, and living to 150? We get into all of it.Timestamps* 00:05 – Intro* 01:35 – Meet Dr. Axel Schumacher* 02:21 – From Genomics to Social Science (The Pivot)* 04:28 – How Loneliness Affects Your Health Span* 06:36 – The Loneliness Epidemic & Declining Birth Rates* 07:47 – Why Is Social Health So Hard to Measure?* 09:56 – The Holt-Lunstad Meta-Analysis Explained* 10:47 – Introducing the Social Connectivity Value (SCV)* 12:44 – The Sociogram: Mapping Your Social World* 13:13 –Building Your Sociogram: Mapping Social Connections* 14:54 – The Dunbar Layers: Your 3 Social Circles* 15:22 – The Invisible Load: Identifying Energy-Draining Relationships* 17:03 – The Invisible Load of Toxic Relationships* 20:09 – The Role of Family and Close Connections* 22:38 – What Is Your SCV Score?* 24:51 – How Your Nervous System Responds to Others* 28:08 – Tracking Your Social Life Like a Biohacker* 30:44 – Introverts vs Extroverts & Social Energy* 31:49 – AI Companions & The Future of Connection* 35:31 – Should Your Partner Be Everything?* 37:34 – Weak Ties & Super Connectors* 41:37 – The Mathematical Magic of Super Connectors* 42:57 – Rapid Fire: Social Media — Net Positive or Negative?* 43:51 – SCV vs Epigenetic Clocks: Which Matters More?* 44:59 – The Best City for Human Connection* 47:12 – One Weekly Habit to Protect Your Social HealthABOUT DR. AXEL SCHUMACHER: Longevity scientist and epigenetics researcher with over 25 years of experience, believes the most powerful biomarker for how long you live isn't in your blood it's in your relationships. After decades at the forefront of genomics and biomarker discovery, he now focuses on quantifying human connection, developing the Social Connectivity Value (SCV), a first-of-its-kind framework to measure your social network as a health metric and longevity tool.RESOURCES MENTIONED: * Website: https://www.grailmaster.com* YouTube ‘Inside the Dating Mind': https://bit.ly/4s2U2i4* Axel's Longevity Protocol: https://bit.ly/4qIL0pZ* Sociogram Preprint with DOI: https://doi.org/10.31235/osf.io/m6h58_v1* X: https://x.com/TheGrailmaster* Instagram: https://www.instagram.com/the_grailmaster/* LinkedIn: https://www.linkedin.com/in/draxelschumacher/ABOUT NINA'S NOTES: Nina's Notes explores the intersection of longevity science, neuroscience, and human optimization. Hosted by Nina Patrick, PhD in pharmaceutical sciences and longevity researcher, each episode translates cutting-edge research into actionable insights for living longer, better.CONNECT WITH NINA'S NOTESNewsletter:LinkedIn: https://www.linkedin.com/in/ninapatrick/Website: https://www.ninapatrick.xyzThanks for reading Nina's Notes! This post is public so feel free to share it. Get full access to Nina's Notes at www.ninasnotes.xyz/subscribe

BUFFALO, NY – June 2, 2026 – A new #research paper was #published in Volume 17 of Oncotarget on May 20, 2026, titled “Microenvironmental CTHRC1 has a pro-tumorigenic role in colorectal cancer.” The study was led by first author Haylee Duval from the Center for Molecular Medicine at the MaineHealth Institute for Research and the Graduate School of Biomedical Science and Engineering at the University of Maine. The study's corresponding authors were Sergey Ryzhov, Volkhard Lindner, and Michaela R. Reagan, who are affiliated with the Center for Molecular Medicine at the MaineHealth Institute for Research, the Graduate School of Biomedical Science and Engineering at the University of Maine, and Tufts University School of Medicine. Colorectal cancer remains one of the leading causes of cancer-related deaths worldwide. While much research has focused on cancer cells themselves, growing evidence suggests that the tumor microenvironment—the network of surrounding stromal cells, immune cells, and extracellular components—plays a critical role in determining how tumors grow and spread. In this study, researchers investigated collagen triple helix repeat containing 1 (CTHRC1), a secreted protein previously associated with poor outcomes in several cancer types. Although CTHRC1 is frequently detected in tumor-associated stroma, its precise role within the colorectal cancer microenvironment has remained unclear. To address this question, the team used a genetically engineered mouse model lacking CTHRC1 and compared tumor development with that of normal mice after colorectal cancer cells were introduced. The results consistently showed that the absence of host-derived CTHRC1 significantly reduced tumor growth. Across three independent experimental cohorts, mice lacking CTHRC1 developed substantially smaller tumors than their normal counterparts. In addition, survival improved markedly. The median survival of mice with normal CTHRC1 expression was 28 days after tumor inoculation, compared with 69 days in CTHRC1-deficient mice. The researchers also found evidence that CTHRC1 influences anti-tumor immunity. Mice lacking CTHRC1 had higher percentages of CD3-positive T cells in both tumors and spleens, suggesting a more active immune response against cancer. At the same time, they exhibited reduced levels of certain myeloid immune cells associated with immune suppression. Importantly, the investigators confirmed that the colorectal cancer cells themselves did not produce detectable CTHRC1. Instead, the protein was found primarily in fibroblasts and other stromal components surrounding the tumor. This finding indicates that the tumor-promoting effects originated from the tumor microenvironment rather than from the cancer cells directly. Histological analyses further revealed striking differences in tumor structure. Tumors from CTHRC1-deficient mice contained fewer cells and showed evidence of regression, while tumors in normal mice remained densely cellular and continued to expand. Full press release - https://www.oncotarget.com/news/pr/protein-in-tumor-microenvironment-found-to-promote-colorectal-cancer-growth-and-immune-evasion/ DOI - https://doi.org/10.18632/oncotarget.28878 Correspondence to: Sergey Ryzhov - Sergey.Ryzhov@mainehealth.org; Volkhard Lindner- Volkhard.Lindner@mainehealth.org; Michaela R. Reagan - Michaela.Reagan@mainehealth.org Abstract video - https://www.youtube.com/watch?v=gTbYy6vGd7E To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Shota Yamamoto, MD, PhD; Takayuki Niitsu, MD; and Kenneth N. Olivier, MD, MPH, join CHEST® Journal Podcast Moderator Gretchen Winter, MD, to discuss their research into the current efficacy and safety profile of antiinflammatory therapies for bronchiectasis.   DOI: 10.1016/j.chest.2025.12.035 Disclaimer: The purpose of this activity is to expand the reach of CHEST content through awareness, critique, and discussion. All articles have undergone peer review for methodologic rigor and audience relevance. Any views asserted are those of the speakers and are not endorsed by CHEST. Listeners should be aware that speakers' opinions may vary and are advised to read the full corresponding journal article(s) for complete context. This content should not be used as a basis for medical advice or treatment, nor should it substitute the judgment used by clinicians in the practice of evidence-based medicine.  

What's the episode about?In this episode, hear Professor Sandra Ruiz on poetry, writing, form, Brown Study, Ricanness, anticoloniality, grief-work, walking and being with the dead, and minoritarian aestheticsWho is Sandra?Sandra Ruiz is the author of Ricanness: Enduring Time in Anticolonial Performance; Left Turns in Brown Study; and Tears for Tears: Aesthetics in Grief Minor. Ruizis the co-author with Hypatia Vourloumis of Formless Formation: Vignettes for the End of this World and The Alleys: Just Dropped in to See What Condition My Condition Was In andco-editor with Shane Vogel & Uri McMillan of the NYU Press book series Minoritarian Aesthetics. When not writing and editing, Ruiz curates and produces through the Minor Aesthetics Lab. At the University of Illinois at Urbana-Champaign, Sandra Ruiz is the Sue Divan Professor of Performance Studies in the Department of Theatre.The special issue on gendered death in visual culture mentioned in the introduction is here.How do I cite the episode in my research and reading lists?To cite this episode, you can use the following citation:Ruiz, S. (2026) Interview on The Death Studies Podcast hosted by Michael-Fox, B. and Visser, R. Published 1 June 2026. Available at: www.thedeathstudiespodcast.com, DOI: 10.6084/m9.figshare.32529204What next?Check out more episodes or find out more about the hosts! Got a question? Get in touch.

The study you should read this week A 2016 meta-analysis from the CMAJ pulled together 46 prospective cohort studies — 1.2 million people, 78,000 deaths. The finding: for every 10 beats per minute higher your resting heart rate sits, your all-cause mortality risk goes up about 9 per cent. Linear from 45 bpm upward, no point where lower stops being better. Independent of blood pressure, smoking, BMI, cholesterol, diabetes, and physical activity. Resting heart rate is carrying its own signal. Plus what to do with this if you race, ride high volume, or train time-capped — and why the adaptations that lower your resting heart rate are the same adaptations that predict a longer, healthier life. Study: Zhang D, Shen X, Qi X. Resting heart rate and all-cause and cardiovascular mortality in the general population: a meta-analysis. CMAJ 2016;188(3):E53–E63. DOI: 10.1503/cmaj.150535 Links: YouTube companion: Cyclist Over 50? Your Fitness Can't Tell You This. Guided is live — two coaches, weekly review, my read behind every plan: https://go.semiprocycling.com/go/btsmfgDaily cycling intelligence from SEMIPRO CYCLING, produced with AI-assisted research, scripting, and synthetic voice.

Could artificial intelligence identify Peripheral Artery Disease before patients face limb loss? Researchers at UC San Diego have developed a machine-learning model that analyzes a simple light-based signal from the toe to detect PAD with remarkable accuracy. This breakthrough has the potential to make PAD screening faster, more accessible, and eventually available on your smartphone. Kym McNicholas and Dr. John Phillips sit down with vascular surgeon Dr. Elsie Ross, cardiologist Dr. Mattheus Ramsis, and engineering PhD student Ava Faccetti to break down how artificial intelligence is transforming vascular health and what this could mean for millions living with undiagnosed disease. FULL RESEARCH DISCUSSION: Altmetric: https://www.nature.com/articles/s41746-026-02655-w/metrics DOI: https://doi.org/10.1038/s41746-026-02655-w   People who think they have PAD can call the Global PAD Associaton's Leg Saver Hotline at 1-833-PAD-LEGS to learn more and get assistance finding a testing site or treatment.   #peripheralarterydisease #padsupport #legpain #legcramps #ABItest #vasculardiseasediagnosis #paddiagnosis #ucsandiego #newpadresearch #globalpadassociation

This week we review a recent report from the team at Amrita Institute in Cocchin, India about their use of extended reality and virtual reality as well as heart model printing to aid in planning for complex intracardiac baffles for the treatment of complex congenital heart defects. What was the process used to provide actionable advice in the operating room during surgery? How has the team in southern India created a workflow that can accurately predict this complex anatomy and the patches needed to successfully septate complex hearts? We speak with the director of the 3D imaging group at Amrita, Professor Mahesh Kappanayil about this remarkable achievement of imaging in collaboration with surgery. DOI: 10.1016/j.jtcvs.2026.03.616

In this episode, Lillian Erdahl, MD, FACS, is joined by Pringl Miller, MD, FACS, from Physican Just Equity, and Christine Heisler, MD, FACS, from the Mayo Clinic Health System. They discuss Drs Miller and Heisler's recent article, “Whether and How Surgeons Took Action Against Workplace Microaggression: Survey of American College of Surgeons Members,” in which the authors found that the most frequent perpetrator roles were surgeon colleagues and supervisors. A total of 57.4% of surgeons took action, with informal reporting to a colleague and/or directly confronting the perpetrator being most common actions taken. Surgeons who took action were less likely to choose a career in surgery again.   Disclosure Information: Drs Erdahl, Miller, and Heisler have nothing to disclose.   To earn 0.25 AMA PRA Category 1 Credits™ for this episode of the JACS Operative Word Podcast, click here to register for the course and complete the evaluation. Listeners can earn CME credit for this podcast for up to 2 years after the original air date.   Heisler, Christine A MD, MS, FACS; Godecker, Amy L PhD, MS; Verran, Deborah MbChB, MHSM; Sinha, Michael S MD, JD, MPH; Byam, Jerome MD; Miller, Pringl MD, FACS. Whether and How Surgeons Took Action Against Workplace Microaggression: Survey of the American College of Surgeons Members. Journal of the American College of Surgeons 242(2):p 390-400, February 2026. | DOI: 10.1097/XCS.0000000000001648   Related work: Primary Study: Heisler CA, Godecker AL, Verran D, Sinha MS, Byam J, Miller P. Workplace microaggressions: results of a survey of the American College of Surgeons members. Am J Obstet Gynecol. 2024 Aug;231(2):265.e1-265.e8.   Secondary Study: Heisler CA, Godecker AL, Verran D, Sinha MS, Byam J, Miller P. Impact of Workplace Microaggressions on Surgeon Career Status and Trajectory: A Cross-Sectional Survey Study.  Accepted to the Annals of Surgery Open on April 30, 2026.     The secondary study was also presented at ACS Clinical Congress 2024: Heisler CA, Godecker A, Verran D, Sinha MS, Byam J, Miller P. Workplace Microaggressions and the Impact on a Surgeon's Career Trajectory: Results of a Survey of the American College of Surgeons Members. J Am Coll Surg. October 2024;239(5):S138-139.   Learn more about the Journal of the American College of Surgeons, a monthly peer-reviewed journal publishing original contributions on all aspects of surgery, including scientific articles, collective reviews, experimental investigations, and more.   #JACSOperativeWord

CardioNerds Dr. Joseph Kassab, Dr. Mariana Garcia-Arango, and Dr. Christopher Mason explore the technological revolution of Coronary CT Angiography (CCTA) with expert faculty Dr. Michael Gallagher. The discussion details how CCTA has evolved into a frontline diagnostic and preventive tool, moving beyond simple anatomy to incorporate physiology via CT-FFR and biology through AI-driven plaque quantification. The episode reviews landmark evidence like the SCOT-HEART and PROMISE trials, the nuances of CAD-RADS 2.0 reporting, and the emerging role of AI in monitoring treatment response and personalizing cardiovascular care. Critically, they also discuss some of the assumptions and limitations of these techniques. Stay tuned for a matching review article to be submitted to US Cardiology Review, the official Journal of CardioNerds. This episode was supported by an independent medical education grant from HeartFlow. All CardioNerds education is planned, produced, and reviewed solely by CardioNerds.  Enjoy this Circulation Paths to Discovery article to learn more about the CardioNerds mission and journey. US Cardiology Review is now the official journal of CardioNerds! Submit your manuscripts here. CardioNerds Multimodality Cardiovascular Imaging PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll Pearls Shift in Paradigm: CCTA is no longer just an anatomic test; with some key limitations, it can provide anatomy, physiology (CT-FFR), and plaque biology (AI-CPA) in a single non-invasive scan. The “Power of Zero” vs. Plaque: While a normal CCTA has a >95% negative predictive value, future MIs often arise from non-obstructive plaque that traditional stress tests might miss. CAD-RADS 2.0 Utility: The addition of plaque burden modifiers (P1–P4) is a “game changer,” allowing clinicians to identify high-risk patients who need aggressive lipid-lowering despite having only mild stenosis. CT-FFR as a Virtual Stress Test: CT-FFR uses computational fluid dynamics to simulate blood flow, potentially reducing unnecessary invasive catheterizations by approximately 61% without sacrificing safety. Seeing the Invisible: AI-based quantitative plaque analysis (QCPA) can identify “subvisual” plaque and low-attenuation (lipid-rich) components that are the primary drivers of acute coronary syndromes. Show Notes How has the role of CCTA changed compared to traditional functional testing? Historically, stress testing answered “is there ischemia today?”, which often reflects late-stage disease. CCTA identifies disease across the entire spectrum, asking “is there atherosclerosis and how much plaque is present?”. Landmark evidence: SCOT-HEART showed a 41% relative risk reduction in MI at 5 years attributed to intensified preventive therapies, and PROMISE showed CCTA was better at selecting patients who truly needed invasive angiography. Diagnostic CCTA imaging depends on the protocol, contrast timing, heart rate, heart rhythm, breathholding, scanner quality, and several patient factors (obesity, prior stents, heavy calcification, complex bypass anatomy, and motion artifact all may limit imaging). “CCTA is exceptional for the right patient, with the right scanner, and the right team.” What are the key modifiers introduced in CAD-RADS 2.0, and why do they matter? CAD-RADS 2.0 moved beyond stenosis severity to include plaque burden (P0 to P4), high-risk plaque (HRP) features, and the presence of ischemia based on CT-FFR. It serves as a clinical decision support tool: a patient with mild (25-49%) stenosis but “extensive” (P4) plaque burden is considered high risk and warrants aggressive risk factor modification. How is CT-FFR calculated, and when is it most useful in clinical practice? CT-FFR uses resting CCTA data and computational fluid dynamics to create a 3D model of coronary flow during simulated maximal hyperemia. It is often used for intermediate lesions (40–90% stenosis) to predict if they are  ischemia-producing, guiding the decision whether to proceed with invasive angiography.  The assumptions necessary for this computational modeling may not apply well to patients with microvascular dysfunction, significant myocardial scar or prior infarction, or ventricular hypertrophy. Still, data indicate that CT-FFR performs similarly to PET in predicting hemodynamically significant lesions.  CT-FFR performs well at the extremes (either clearly normal or clearly abnormal). Accuracy dips, however, in the intermediate range (~0.75-0.80), where decision-making is most critical. In this grey zone, additional factors can help guide the approach, including the amount of myocardium supplied, translesional gradient, and plaque features.   CT-FFR has not been validated in distal segments, stented segments, heavily calcified coronary arteries, or in patients with severe aortic stenosis. Caution with CT-FFR should be utilized in very calcified coronary segments.  What is AI-based quantitative plaque analysis (QCPA), and what metrics are ready for clinical use? This is potentially a paradigm shift, moving away from stenosis-centric thinking to a more disease burden and plaque biology focus. QCPA uses deep learning algorithms to automatically segment the vessel wall and quantify plaque volume in mm³. Ready for “prime time” metrics include: Total Plaque Volume (TPV), non-calcified plaque volume, and Low-Attenuation Plaque (LAP) burden. Can serial CCTA be used to monitor the effectiveness of medical therapies like statins? While not yet a routine guideline-driven practice, trials like PARADIGM and EVAPORATE show that therapies can stabilize plaque; notably, CCTA is better for monitoring than CAC scores, which can be misleading as statins often increase plaque calcification as part of the stabilization process. There are no randomized trials that serial CCTAs improve outcomes. Cost and radiation exposure will be notable limitations. Serial scan timing, scan acquisition and interpretation standardization would be key. Dr. Gallagher notes that we are moving toward a world in which plaque burden may become a “treatment biomarker,” similar to tumor burden in oncology.  References 1. Coronary Computed Tomography Angiography From Clinical Uses to Emerging Technologies: JACC State-of-the-Art Review. Abdelrahman KM, Chen MY, Dey AK, et al. Journal of the American College of Cardiology. 2020;76(10):1226-1243. doi:10.1016/j.jacc.2020.06.076. 2. Non-Invasive Imaging in Coronary Syndromes: Recommendations of the European Association of Cardiovascular Imaging and the American Society of Echocardiography, in Collaboration With the American Society of Nuclear Cardiology, Society of Cardiovascular Computed Tomography, and Society for Cardiovascular Magnetic Resonance. Edvardsen T, Asch FM, Davidson B, et al. Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography. 2022;35(4):329-354. doi:10.1016/j.echo.2021.12.012. 3. 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Gulati M, Levy PD, Mukherjee D, et al. Journal of the American College of Cardiology. 2021;78(22):e187-e285. doi:10.1016/j.jacc.2021.07.053. 4. Contemporary, Non-Invasive Imaging Diagnosis of Chronic Coronary Artery Disease. van der Bijl P, Gulati M, Saraste A, et al. Lancet (London, England). 2025;406(10519):2577-2587. doi:10.1016/S0140-6736(25)01586-7. 5. State of the Art: Evaluation and Medical Management of Nonobstructive Coronary Artery Disease in Patients With Chest Pain: A Scientific Statement From the American Heart Association. Slipczuk L, Blankstein R, Bucciarelli-Ducci C, et al. Circulation. 2025;152(23):e443-e466. doi:10.1161/CIR.0000000000001394. 6. Diagnostic Performance of Fractional Flow Reserve Derived From Coronary CT Angiography: The ACCURATE-CT Study. Li C, Hu Y, Jiang J, et al. JACC. Cardiovascular Interventions. 2024;17(17):1980-1992. doi:10.1016/j.jcin.2024.06.027. 7. Clinical Outcomes Based on Coronary Computed Tomography-Derived Fractional Flow Reserve and Plaque Characterization. Sato Y, Motoyama S, Miyajima K, et al. JACC. Cardiovascular Imaging. 2024;17(3):284-297. doi:10.1016/j.jcmg.2023.07.013. 8. Clinical Use of Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve: Expert Consensus by an International Working Group. Tang CX, Leipsic JA, Nørgaard BL, et al. European Radiology. 2026;:10.1007/s00330-025-12313-6. doi:10.1007/s00330-025-12313-6. 9. Diagnostic accuracy of computed tomography–derived fractional flow reserve: a systematic review. Cook CM, Petraco R, Shun-Shin MJ, et al. JAMA Cardiol. 2017;2(7):803-810. Doi:10.1001/jamacardio.2017.1314 10. Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in suspected coronary artery disease: the NXT trial (Analysis of Coronary Blood Flow Using CT Angiography: Next Steps). Nørgaard BL, Leipsic J, Gaur S, et al. J Am Coll Cardiol. 2014;63(12):1145-1155. Doi:10.1016/j.jacc.2013.11.043 11. Comparison of coronary computed tomography angiography, fractional flow reserve, and perfusion imaging for ischemia diagnosis. Driessen RS, Danad I, Stuijfzand WJ, et al. J Am Coll Cardiol. 2019;73(2):161-173. Doi:10.1016/j.jacc.2018.10.056. 12. 1-year outcomes of FFRCT-guided care in patients with suspected coronary disease: the PLATFORM study. Douglas PS, De Bruyne B, Pontone G, et al. J Am Coll Cardiol. 2016;68(5):435-445. Doi:10.1016/j.jacc.2016.05.057. 13. Comparison of an initial risk-based testing strategy vs usual testing in stable symptomatic patients with suspected coronary artery disease: the PRECISE randomized clinical trial. Douglas PS, Nanna MG, Kelsey MD, et al; PRECISE Investigators. JAMA Cardiol. 2023;8(10):904-914. Doi:10.1001/jamacardio.2023.2595. 14. Diagnostic and clinical value of FFRCT in stable chest pain patients with extensive coronary calcification: the FACC study. Mickley H, Veien KT, Gerke O, et al. JACC Cardiovasc Imaging. 2022;15(6):1046-1058. doi:10.1016/j.jcmg.2021.12.010. 15. Low-Attenuation Noncalcified Plaque on Coronary Computed Tomography Angiography Predicts Myocardial Infarction: Results From the Multicenter SCOT-HEART Trial (Scottish Computed Tomography of the HEART). Williams MC, Kwiecinski J, Doris M, et al. Circulation. 2020;141(18):1452-1462. doi:10.1161/CIRCULATIONAHA.119.044720. 16. AI-Guided Quantitative Plaque Staging Predicts Long-Term Cardiovascular Outcomes in Patients at Risk for Atherosclerotic CVD. Nurmohamed NS, Bom MJ, Jukema RA, et al. JACC. Cardiovascular Imaging. 2024;17(3):269-280. doi:10.1016/j.jcmg.2023.05.020. 17. Interaction of AI-Enabled Quantitative Coronary Plaque Volumes on Coronary CT Angiography, FFRCT, and Clinical Outcomes: A Retrospective Analysis of the ADVANCE Registry. Dundas J, Leipsic J, Fairbairn T, et al. Circulation. Cardiovascular Imaging. 2024;17(3):e016143. doi:10.1161/CIRCIMAGING.123.016143. 18. Prognostic Value of AI-Based Quantitative Coronary CTA vs Human Reader-Based Visual Assessment: Results From the CONFIRM2 Registry. van Rosendael A, Nakanishi R, Bax JJ, et al. JACC. Cardiovascular Imaging. 2026;19(3):345-359. doi:10.1016/j.jcmg.2025.09.021.13. Pericoronary Adipose Tissue as a Marker of Cardiovascular Risk: JACC Review Topic of the Week. Tan N, Dey D, Marwick TH, Nerlekar N. Journal of the American College of Cardiology. 2023;81(9):913-923. doi:10.1016/j.jacc.2022.12.021. 19. Effect of Icosapent Ethyl on Progression of Coronary Atherosclerosis in Patients With Elevated Triglycerides on Statin Therapy: Final Results of the EVAPORATE Trial. Budoff MJ, Bhatt DL, Kinninger A, et al. European Heart Journal. 2020;41(40):3925-3932. doi:10.1093/eurheartj/ehaa652. 20. Coronary CT Angiography Evaluation With Artificial Intelligence for Individualized Medical Treatment of Atherosclerosis: A Consensus Statement From the QCI Study Group. Schulze K, Stantien AM, Williams MC, et al. Nature Reviews. Cardiology. 2026;23(2):100-115. doi:10.1038/s41569-025-01191-6.

Eric Rubin is the Editor-in-Chief of the Journal. Lindsey Baden is a Deputy Editor of the Journal. Angela Hewlett is Director of the Nebraska Biocontainment Unit. Steven Kornfeld is a physician who was a passenger on the MV Hondius. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. E.J. Rubin and Others. NEJM Outbreaks Update — Andes Hantavirus. N Engl J Med. DOI: 10.1056/NEJMe2505379.

Carlos Juan Finlay was a Cuban doctor who did a lot of work to understand the spread of Yellow Fever. But Walter Reed got most of the credit. Research: American Experience. “Carlos Finlay (1833-1915).” From The Great Fever. PBS. https://www.pbs.org/wgbh/americanexperience/features/fever-carlos-finlay/ Berenbrok, Dorothy E., "Latin Heritage Month. Carlos Juan Finlay: Outrageous, Courageous and Correct" (2015). Posters: Jefferson History. 3. https://jdc.jefferson.edu/jeffhistoryposters/3 "Carlos Juan Finlay." Encyclopedia of World Biography Online, Gale, 1998. Gale In Context: Opposing Viewpoints, link.gale.com/apps/doc/K1631002194/GPS?u=mlin_n_melpub&sid=bookmark-GPS&xid=bfeecc25. Accessed 29 Apr. 2026. Chaves-Carballo, Enrique. “Carlos J. Finlay: The mosquito man.” Hektoen International. 11/2/2020. https://hekint.org/2020/11/02/carlos-j-finlay-the-mosquito-man/ Corbitt, Duvon C. “Carlos J. Finlay, Cuban Physician.” The Hispanic American Historical Review, Vol. 45, No. 3 (Aug., 1965). Via JSTOR. https://www.jstor.org/stable/2511751 Del Regato, Juan A. “Carlos Juan Finlay (1833-1915).” Journal of Public Health Policy , 2001, Vol. 22, No. 1 (2001). Via JSTOR. https://www.jstor.org/stable/3343556 Faerstein, Eduardoa; Winkelstein, Warren Jrb. Carlos Juan Finlay: Rejected, Respected, and Right. Epidemiology 21(1):p 158, January 2010. | DOI: 10.1097/EDE.0b013e3181c308e0 Ferreira Moreno, Víctor Guillermo. “Evocation to the Dr. Carlos J. Finlay Barres on the centennial of his death.” Colombia medica (Cali, Colombia) vol. 47,1 63-6. 30 Mar. 2016 Finlay, Carlos J. “The Mosquito Hypothetically Considered as the Agent of Transmission of Yellow Fever.” Read before the Royal Academy of Medical, Physical and Natural Sciences Session of August 14th, 1881. https://archive.org/details/b33448541/page/590/mode/1up Finlay, Carlos Juan. “Trabajos selectos del Dr. Carlos J. Finlay. Selected papers of Dr. Carlos J. Finlay.” Habana. 1912. https://archive.org/details/trabajosselectos00finl Finlay, Charles. “Inoculations for Yellow Fever by Means of Contaminated Mosquitoes.” Published in The American Journal of the Medical Sciences, n.s. 102: 264-268, 1891. https://archive.org/details/b33445242/page/n4/mode/1up Finlay, Charles. “Yellow Fever: Its ‘Transmission by Means of the Culex Mosquito.” Published in The American Journal of the Medical Sciences, n.s. 92: 395-409, 1886. https://archive.org/details/b33435698/page/613/mode/1up Palmer, Steven. “A Cuban Scientist Between Empires: Peripheral Vision on Race and Tropical Medicine.” Canadian Journal of Latin American and Caribbean Studies / Revue canadienne desétudes latino-américaines et caraïbes, Vol. 35, No. 69, Special Issue: Landscapes of LatinAmerican Health, 1870-1970. Via JSTOR. https://www.jstor.org/stable/41800498 Spears, Ellen Griffith and Rosa López-Oceguera. “Carlos Juan Finlay, William Gorgas, and Walter Reed and the U.S. Army Yellow Fever Controversy: Competing Historical Memories.” Alabama Review The University of Alabama Press. Volume 74, Number 1, January 2021. https://doi.org/10.1353/ala.2021.0011 Stepan, Nancy. “The Interplay between Socio-Economic Factors and Medical Science: Yellow Fever Research, Cuba and the United States.” Social Studies of Science , Nov., 1978, Vol. 8, No. 4 (Nov., 1978). Via JSTOR. http://www.jstor.com/stable/284817 Thomas Jefferson University. “10 Notable Jefferson Alumni of the Past.” https://library.jefferson.edu/archives/exhibits/notable_alumni/juan_carlos_finlay.cfm Tone, John Lawrence. (2002) “How the mosquito (man) liberated Cuba.” History and Technology, 18:4, 277-308, DOI: 10.1080/07341512.2002.11417735 “Carlos J. Finlay.” 5/16/2023. https://www.unesco.org/en/prizes/carlos-j-finlay/about Woodall, Jack. "Yellow Fever." Infectious Diseases: In Context, edited by Brenda Wilmoth Lerner and K. Lee Lerner, vol. 2, Gale, 2008, pp. 925-931. In Context Series. Gale In Context: Opposing Viewpoints, link.gale.com/apps/doc/CX3045200265/GPS?u=mlin_n_melpub&sid=bookmark-GPS&xid=bf646a26. Accessed 29 Apr. 2026. See omnystudio.com/listener for privacy information.

Outside of pregnancy, guidelines emphasize diabetes self-management education and support to facilitate informed decision making, self-care behaviors, problem solving, and active collaboration with health care professionals. This includes, in those with good health literacy, the concept of patient-led self-titration of basal insulin results which has data that it improves glycemic management compared with clinician-led titration for type 2 diabetes among nonpregnant adults. But what about for GDM? Can patient's self manage their BASAL insulin? In this episode, we will review a new RCT published in April 2026 in the Green Journal on this very subject. As novel as this is, it is not the first to report on this as it was also published (retrospective study in the UK) in 2022. This is a novel approach to insulin in GDM but there are some questions that remain. Listen in for details.1. Boonpattharatthiti K, Wechkunanukul K, Mayang N, et al . Comparison of Insulin Titration Strategies for Glycemic Control in Type 2 Diabetes: A Systematic Review and Network Meta-Analysis.Diabetes Care. 2025. 2. Valent, Amy M. DO, MCR; Barbour, Linda A. MD, MSPH. Insulin Management for Gestational and Type 2 Diabetes in Pregnancy. Obstetrics & Gynecology 144(5):p 633-647, November 2024. | DOI: 10.1097/AOG.00000000000056403. Wang, Xiao-Yu MD; Gabbe, Steven MD; Landon, Mark B. MD; Venkatesh, Kartik K. MD, PhD et al. Patient-Led Insulin Titration for Glycemic Management With Gestational Diabetes Mellitus: A Randomized Controlled Trial. Obstetrics & Gynecology 147(4):p 501-509, April 2026. 4. McGovern AP, Hirwa KD, Wong AK, et al. Patient-led rapid titration of basal insulin in gestational diabetes is associated with improved glycaemic control and lower birthweight. Diabet Med. 2022;39:e14926. doi: 10.1111/dme.14926

Big Thunder Topic from Trammin' Episode 304Hear the Trams echoing tonightBut she hears only whispers of some quiet transportationShe's comin' in, 12:30 flightHer moonlit wings reflect the stars that guide me towards OrlandoI stopped an old man at Cabana BayHopin' to find some old forgotten worlds or isles of discoveryHe turned to me as if to say"Hurry, boy, it's waiting there for you"It's gonna take a lot to drag me away from U(niversal)There's nothin' that a hundred minutes in line could ever doI bless The Rains down in FloridaGonna take some time to ride the rides we never had, ooh-hooThe listeners cry out in the nightAs they grow restless longing for some solid commentaryWe know that we must do what's rightSure as Kilimanjaro rises like Everest above the ContemporaryWe seek to cure what's deep insideFrightened of this show that we've becomeIt's gonna take a lot to drag me away from youThere's nothin' that a hundred Florida men could ever doI bless The Rains down in FloridaGonna take some time to drink the drinks we never had, ooh-hooJoin Kirk & Rain as they recap Rain's wild time in Orlando between Universal and Walt Disney World on a Toto-lly new episode of Trammin' - A Disneyland Podcast!Listen to full episodes every other Windsday and topic-only uploads on Big Thunder Thursdays!InstagramTrammin' - https://instagram.com/TramminPodcastChristian Rainwater - https://instagram.com/imrainwaterKirk - https://instagram.com/tramminkirkMusicLocal Forecast - Elevator Kevin MacLeod (incompetech.com)Licensed under Creative Commons: By Attribution 3.0 Licensehttp://creativecommons.org/licenses/by/3.0/ Trammin' - The Disneylanders, Addy DaddyUsed with permission.Character Art & AnimationNadia Dar - https://nadsdardraws.carrd.co/Trammin.comTrammin' is written without the use of Artificial Intelligence.©Trammin' - A Disneyland Podcast

Hear the Trams echoing tonightBut she hears only whispers of some quiet transportationShe's comin' in, 12:30 flightHer moonlit wings reflect the stars that guide me towards OrlandoI stopped an old man at Cabana BayHopin' to find some old forgotten worlds or isles of discoveryHe turned to me as if to say"Hurry, boy, it's waiting there for you"It's gonna take a lot to drag me away from U(niversal)There's nothin' that a hundred minutes in line could ever doI bless The Rains down in FloridaGonna take some time to ride the rides we never had, ooh-hooThe listeners cry out in the nightAs they grow restless longing for some solid commentaryWe know that we must do what's rightSure as Kilimanjaro rises like Everest above the ContemporaryWe seek to cure what's deep insideFrightened of this show that we've becomeIt's gonna take a lot to drag me away from youThere's nothin' that a hundred Florida men could ever doI bless The Rains down in FloridaGonna take some time to drink the drinks we never had, ooh-hooJoin Kirk & Rain as they recap Rain's wild time in Orlando between Universal and Walt Disney World on a Toto-lly new episode of Trammin' - A Disneyland Podcast!Listen to full episodes every other Windsday and topic-only uploads on Big Thunder Thursdays!InstagramTrammin' - https://instagram.com/TramminPodcastChristian Rainwater - https://instagram.com/imrainwaterKirk - https://instagram.com/tramminkirkMusicLocal Forecast - Elevator Kevin MacLeod (incompetech.com)Licensed under Creative Commons: By Attribution 3.0 Licensehttp://creativecommons.org/licenses/by/3.0/ Trammin' - The Disneylanders, Addy DaddyUsed with permission.Character Art & AnimationNadia Dar - https://nadsdardraws.carrd.co/Trammin.comTrammin' is written without the use of Artificial Intelligence.©Trammin' - A Disneyland Podcast

Hyperemesis gravidarum (HG) represents the most severe end of the nausea and vomiting of pregnancy spectrum. It has a reported incidence of approximately 0.3–3% of pregnancies and is the most common cause of hospitalization in early pregnancy and the second most common cause of hospitalization in pregnancy overall. In June 2024, the ACOG published a Clinical Expert series summarizing the inpatient management of HG. In that guidance, it describes mirtazapine as an “alternative pharmacologic” option. How effective is this medication compared to ondansetron? A new study (published ahead of print on 12/30/25 and officially out June 2026), out of Denmark, sheds some new light on this medication. This trial is the first double-blind RCT comparing mirtazapine to ondansetron AND placebo. Although a BIG limitation of this study exists (which we will discuss), it does provide some interesting insights. Listen in for details.1. (ACOG CES) Clark, Shannon M. MD; Zhang, Xue MD; Goncharov, Daphne Arena MD. Inpatient Management of Hyperemesis Gravidarum. Obstetrics & Gynecology 143(6):p 745-758, June 2024. | DOI: 10.1097/AOG.00000000000055182. Ostenfeld, AnneDroogh, Marjoes et al.Mirtazapine or ondansetron for hyperemesis gravidarum. A randomized placebo-controlled trial. American Journal of Obstetrics & Gynecology, June 2026

The study you should read this week Researchers took 55 untrained older adults (average age 68) and tested four different cycling methods over four weeks: standard cycling, hypoxic cycling, blood flow restriction, and eccentric cycling. Every group improved equally. Plain cycling was just as effective as every fancy method they tested. Plus: why most of the plans I built this week were about adding intensity, not volume, and what that means for your training this summer. Study: Citherlet et al. (2025). Effectiveness of short-term cycling interventions in older adults. Scientific Reports, 15, 25914. DOI: 10.1038/s41598-025-10550-9 Links: Event Readiness Check: https://go.semiprocycling.com/go/2au9cy YouTube: The 4-Hour Cycling Week That Actually Works Coaching: https://www.semiprocycling.com/coachingDaily cycling intelligence from SEMIPRO CYCLING, produced with AI-assisted research, scripting, and synthetic voice.

United States v. Bhagat Singh Thind was a 1923 case that hinged on what it meant to be white. Research: “Ozawa v. United States, 260 U.S. 178 (1922).” https://supreme.justia.com/cases/federal/us/260/178/ “United States v. Bhagat Singh Thind, 261 U.S. 204 (1923).” https://supreme.justia.com/cases/federal/us/261/204/ de la Garza, Amanda. “Doctorji: The Life. Teachings, and Legacy of Dr. Bhagat Singh Thind.” David Bhagat Thind. 2010. Deslippe, Philip. “Bhagat Singh Thind in Jail.” SAADA. https://www.saada.org/tides/article/bhagat-singh-thind-in-jail Deslippe, Philip. “Doctorji the Divorcé: Understanding Bhagat Singh Thind Through His Marriage to Inez Buelen.” Ethnic Studies Review 1 July 2023; 46 (1-2): 52–68. doi: https://doi.org/10.1525/esr.2023.46.1-2.52 Kanwar, Joy. “Stories from the Negative Spaces: United States v. Thind and the Narrative of (Non)Whiteness.” Mercer Law Review. Vol. 74, No. 3. 2023. https://digitalcommons.law.mercer.edu/cgi/viewcontent.cgi?article=3111&context=jour_mlr Munshi, Sherally. “Remembering Thind.” Ethnic Studies Review, Vol. 46, Issue 1-2, pp. 98–116. DOI: https://doi.org/10.1525/esr.2023.46.1-2.98 Ogden, Johanna. “The Telling Case of Doctor Bhagat Singh Thind.” Oregon Historical Quarterly. Vol. 124, No. 1. 2023. https://www.ohs.org/oregon-historical-quarterly/back-issues/upload/Ogden_Baghat-Singh-Thind_OHQ-124_1_Spring-2023_web.pdf “Bhagat Singh Thind.” Roots in the Sand. 2000. https://www.pbs.org/rootsinthesand/i_bhagat1.html Pillai, Daksha. “United States v. Bhagat Singh Thind: Dual Legacies of a Forgotten Supreme Court Case.” Gilder Lehrman Institute of American History. https://www.gilderlehrman.org/sites/default/files/file_media/38_Pillai.pdf Qin, Amy. “In the Birthright Citizenship Hearing, a Story of Asians Fighting for Rights.” New York Times. 4/2/2026. https://www.nytimes.com/2026/04/02/us/politics/birthright-citizenship-asian-immigrants.html Shankar, Arjun. “On Brown Blood Race, Caste, and the Bhagat Singh Thind Case.” Ethnic Studies Review, Vol. 46, Issue 1-2, pp. 135–155. DOI: https://doi.org/10.1525/esr.2023.46.1-2.135 Smith, Marian L. “Race, Nationality, and Reality: INS Administration of Racial Provisions in U.S. Immigration and Nationality Law Since 1898.” Prologue. Vol. 34, No. 2. Summer 2002. https://www.archives.gov/publications/prologue/2002/summer/immigration-law-1 South Asian American Digital Archive. “The Problem.” https://www.saada.org/explore/exhibits/theproblem Supreme Court of the United States. “Donald J. Trump, president of the United States et al., petitioners, v. Barbara et al, Respondents.” No. 25-365. Oral arguments. Heritage Reporting Corporation. April 1, 2026. https://www.supremecourt.gov/oral_arguments/argument_transcripts/2025/25-365_l6gn.pdf The Pluralism Project. “The Ghadar Party: Freedom for India.” Harvard University. https://pluralism.org/the-ghadar-party-freedom-for-india See omnystudio.com/listener for privacy information.

Part one of this quarter's edition of Unearthed! includes animals, artwork, edibles and potables, shipwrecks, potpourri. Research: Abdallah, Hannah. “Analysis of charred food in pot reveals that prehistoric Europeans had surprisingly complex cuisines.” EurekAlert. 3/4/2025. https://www.eurekalert.org/news-releases/1117763 Almeroth-Williams, Thomas. “British redcoat’s lost memoir reveals harsh realities of life as a disabled veteran.” EurekAlert. 1/14/2026. https://www.eurekalert.org/news-releases/1111595 Anderson, Sonja. “Does This Skeleton Found Beneath a Dutch Church Belong to D’Artagnan, the Man Who Inspired ‘The Three Musketeers’?” Smithsonian. 3/27/2026. https://www.smithsonianmag.com/smart-news/this-skeleton-found-beneath-the-floor-of-a-dutch-church-may-belong-to-dartagnan-the-fourth-musketeer-180988448/ Anderson, Sonja. “Historians Thought This Rare Renaissance Portrait by One of the First Famous Female Artists Was Lost to History—Until It Surfaced in North Carolina.” 2/3/2026. https://www.smithsonianmag.com/smart-news/historians-thought-this-rare-renaissance-portrait-by-one-of-the-first-famous-female-artists-was-lost-to-history-until-it-surfaced-in-north-carolina-180988120/ Anderson, Sonja. “Hundreds of Ancient Roman Blade Sharpeners Emerge From a Riverbank in England, Revealing the Ruins of a 2,000-Year-Old Whetstone Factory.” Smithsonian. 1/20/2026. https://www.smithsonianmag.com/smart-news/hundreds-of-ancient-roman-blade-sharpeners-emerge-from-a-riverbank-in-england-revealing-the-ruins-of-a-2000-year-old-whetstone-factory-180988016/ Anderson, Sonja. “The Italian Government Just Paid Nearly $35 Million for a Rare Caravaggio Portrait—One of the Most Expensive Artworks It’s Ever Acquired.” Smithsonian. 3/16/2026. https://www.smithsonianmag.com/smart-news/the-italian-government-just-paid-nearly-35-million-for-a-rare-Caravaggio-portrait-one-of-the-most-expensive-artworks-its-ever-acquired-180988344/ Arnold, Paul. “Poop as medicine? A Roman vial's chemistry backs up ancient medical texts.” Phys.org. 2/4/2026. https://phys.org/news/2026-02-poop-medicine-roman-vial-chemistry.html Arnold, Paul. “Scents of the afterlife: Identifying embalming recipes by 'sniffing' the air around Egyptian mummies.” Phys.org. 2/5/2026. https://phys.org/news/2026-02-scents-afterlife-embalming-recipes-sniffing.html#google_vignette Bacon, Jordan. “English history’s biggest march is a myth – King Harold sailed to the Battle of Hastings.” EurekAlert. 3/20/2026. https://www.eurekalert.org/news-releases/1120082 Bastola, Kunjal. “A Groundskeeper Noticed a Sinkhole on a Golf Course. It Turned Out to Be a Wine Cellar Full of Empty Bottles, Untouched for More Than 100 Years.” Smithsonian. 3/19/2026. https://www.smithsonianmag.com/smart-news/a-groundskeeper-noticed-a-sinkhole-on-a-golf-course-it-turned-out-to-be-a-wine-cellar-full-of-empty-bottles-untouched-for-more-than-100-years-180988379/ Bastola, Kunjal. “A Little Boy’s Library Book Was Due in 1989. Thirty-Six Years Later, He Realized His Parents Had Never Returned It.” Smithsonian. 1/26/2026. https://www.smithsonianmag.com/smart-news/a-little-boys-library-book-was-due-in-1989-thirty-six-years-later-he-realized-his-parents-had-never-returned-it-180988046/ Baum, Stephanie. “Ancient parrot DNA reveals sophisticated, long-distance animal trade network pre-dating the Inca Empire.” 3/10/2026. https://phys.org/news/2026-03-ancient-parrot-dna-reveals-sophisticated.html Baum, Stephanie. “From the Late Bronze Age to today, the Old Irish Goat carries 3,000 years of Irish history.” 2/26/2026. https://phys.org/news/2026-02-late-bronze-age-today-irish.html Benzine, Vittoria. “What Did Pompeii Smell Like? A New Study Analyzes Its Ancient Incense.” Artnet. 3/31/2026. https://news.artnet.com/art-world/pompeii-ritual-incense-study-2760240 Brooks, James. “Danish warship sunk by Nelson’s British fleet discovered after 225 years.” Associated Press. 4/2/2026. https://apnews.com/article/denmark-archaeologists-warship-nelson-copenhagen-dannebroge-lynetteholm-4519533d9e774a490f6020e893634e09 Carvajal, Guillermo. “Archaeologists achieve a historic milestone by dating French cave paintings with carbon-14 for the first time.” 3/10/2025. https://www.labrujulaverde.com/en/2026/03/archaeologists-achieve-a-historic-milestone-by-dating-french-cave-paintings-with-carbon-14-for-the-first-time/ Clayworth, Liv. “Bird poop powered the rise of the Chincha Kingdom, archaeologists find.” EurekAlert. 2/11/2026. https://www.eurekalert.org/news-releases/1115214 “Lost page of the Archimedes Palimpsest identified in Blois, central France.” Phys.org. 3/9/2026. https://phys.org/news/2026-03-lost-page-archimedes-palimpsest-blois.html Ehrlich, Claudia. “Signs on Stone Age objects: Precursor to written language dates back 40,000 years.” EurekAlert. 2/23/2026. https://www.eurekalert.org/news-releases/1117179 Ferrer, Isabel. “Is d’Artagnan lying beneath a church in Maastricht? DNA will determine if remains found are those of the famous musketeer.” El Pais. 3/25/2025. https://english.elpais.com/international/2026-03-25/is-dartagnan-lying-beneath-a-church-in-maastricht-dna-will-determine-if-remains-found-are-that-of-the-famous-musketeer.html?outputType=amp Gebauer, Kathryn. “Groundbreaking discovery reveals Africa’s oldest cremation pyre and complex ritual practices.” EurekAlert. 1/1/2016. https://www.eurekalert.org/news-releases/1111191 Harley, Sadie. “Iron Age dental plaque reveals Scythians consumed milk from horses and ruminants.” Phys.org. 1/21/2026. https://phys.org/news/2026-01-iron-age-dental-plaque-reveals.html He, Ye. “Singapore’s first ancient shipwreck reveals record cargo of Yuan dynasty blue-and-white porcelain.” EurekAlert. 2/12/2026. https://www.eurekalert.org/news-releases/1116512 Johansen, Rikke Tørnsø. “Archaeologists reveal a medieval super ship: "It's the World’s largest cog".” Vikingeskibs Museet. 12/22/2025. https://www.vikingeskibsmuseet.dk/en/news/archaeologists-reveal-a-medieval-super-ship-its-the-worlds-largest-cog Kasal, Krystal. “Hannibal's famous war elephants: Single bone in Spain offers first direct evidence.” Phys.org. 2/5/2026. https://phys.org/news/2026-02-hannibal-famous-war-elephants-bone.html Kasal, Krystal. “Oldest known sewn hide and other artifacts from Oregon caves shed light on early clothing in harsh climates.” Phys.org. 2/10/2026. https://phys.org/news/2026-02-oldest-sewn-artifacts-oregon-caves.html Killgrove, Kristina. “Romans used human feces as medicine 1,900 years ago — and used thyme to mask the smell.” 1/29/2026. https://www.livescience.com/archaeology/romans/romans-used-human-feces-as-medicine-1-900-years-ago-and-used-thyme-to-mask-the-smell Killgrove, Kristina. “Stone Age woman was buried like a man, revealing flexible gender roles 7,000 years ago in Hungary.” LiveScience. 3/3/2026. https://www.livescience.com/archaeology/stone-age-woman-was-buried-like-a-man-revealing-flexible-gender-roles-7-000-years-ago-in-hungary Koc University. “Earliest evidence of indigo-dyed textiles and single-needle knitting discovered in Bronze Age Anatolia.” Phys.org. 2/21/2026. https://phys.org/news/2026-02-earliest-evidence-indigo-dyed-textiles.html Kuta, Sarah. “Did Neanderthals Use Birch Bark Tar as an Antibiotic to Treat Wounds and Infections?” Smithsonian. 3/30/2026. https://www.smithsonianmag.com/smart-news/did-neanderthals-use-birch-bark-tar-as-an-antibiotic-to-treat-wounds-and-infections-180988393/ Kuta, Sarah. “Ostrich Eggshells Suggest Our Ancestors May Have Understood Basic Geometry 60,000 Years Ago.” Smithsonian. 3/9/2026. https://www.smithsonianmag.com/smart-news/these-intricately-decorated-ostrich-eggshells-suggest-our-ancestors-may-have-understood-basic-geometry-60000-years-ago-180988315/ Kuta, Sarah. “Ötzi the Iceman May Have Carried a Cancer-Causing Strain of HPV, a Common Virus Still Plaguing Humans Today.” Smithsonian. 1/20/2026. https://www.smithsonianmag.com/smart-news/otzi-the-iceman-may-have-carried-a-cancer-causing-strain-of-hpv-a-common-virus-still-plaguing-humans-today-180988024/ Kuta, Sarah. “Shipwreck Timbers Appeared on a Beach After a Storm. They Had Been Buried Beneath the Sand Since the 17th Century.” Smithsonian. 3/2/2026. https://www.smithsonianmag.com/smart-news/shipwreck-timbers-appeared-on-a-beach-after-a-storm-they-had-been-buried-beneath-the-sand-since-the-17th-century-180988260/ Lawson-Tancred, Jo. “Salvador Dalí’s Largest Work Snapped Up by Florida Museum.” Artnet. 3/27/2026. https://news.artnet.com/market/salvador-dali-largest-work-bonhams-sale-2749246 Lock, Lisa. “Ancient DNA finds 15,800-year-old dogs in Anatolia, buried like humans.” Phys.org. 3/28/2026. https://phys.org/news/2026-03-ancient-dna-year-dogs-anatolia.html Lock, Lisa. “Are one in 200 men really related to Genghis Khan? Maybe not, according to a new study.” Phys.org. 2/21/2026. https://phys.org/news/2026-02-men-genghis-khan.html Lucibella, Michael. “Prehistoric tool made from elephant bone is the oldest discovered in Europe.” EurekAlert. 1/26/2026. https://www.eurekalert.org/news-releases/1113140 Luscombe, Richard. “Mass grave in Jordan sheds new light on world’s earliest recorded pandemic.” The Guardian. 1/31/2026. https://www.theguardian.com/science/2026/jan/31/plague-of-justinian-pandemic net. “Did King Harold Sail to Hastings? New Study Sparks Debate Among Historians.” 3/2026. https://www.medievalists.net/2026/03/did-king-harold-sail-to-hastings-new-study-sparks-debate-among-historians/ net. “Viking-Age Woman Buried with Her Dog in Norway.” 3/2026. https://www.medievalists.net/2026/03/viking-age-woman-buried-with-her-dog-in-norway/ Newcastle University Press Office. “5,300-year-old ‘bow drill’ rewrites story of ancient Egyptian tools.” 2/9/2026. https://www.ncl.ac.uk/press/articles/latest/2026/02/ancientegyptiandrillbit/ Noraz, R., Chauvey, L., Wagner, S. et al. Ancient DNA reveals 4000 years of grapevine diversity, viticulture and clonal propagation in France. 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