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This week we replay an episode from nearly 2 years ago about an editorial commentary from multiple congenital heart surgical leaders in the US. The topic of their expert opinion piece is the concept of public reporting of results and their 'amplification' through organizations such as US News and World Report, to name one. How has the use of the database from STS been sometimes misinterpreted through public reporting or ranking systems? What was the initial intent of the STS database and how does the present usage of these data differ from the initial intent? Do STS risk adjustment models capture all aspects of risk for patients undergoing surgery and how do deficiencies in this result in unfair 'rankings' of programs? Can we 'take control' of our data and interpret it more clearly and accurately for the public and reduce misusage or misinterpretation of the data? How can public reporting result in improved outcomes? How can 'gaming' of the system be reduced? Dr. Emile Bacha, Professor of Surgery at Columbia University shares his deep insights into a complex and challenging topic.DOI: 10.1016/j.jtcvs.2023.03.022
Send us a textPharmacology & neurobiology of psychedelics & MDMA, focusing on isomers, sex-specific effects, and mechanisms in animal models. Not medical advice.TOPICS DISCUSSED:Biased agonism: Different drugs activate the same receptor (e.g., 5-HT2A) but trigger varied intracellular pathways, explaining why LSD is psychedelic while similar lisuride is not.Enantiomers & isomers: Mirror-image versions of drugs like MDMA (S and R forms) and LSD (four isomers) often produce distinct effects; only one LSD isomer is psychedelic, for example.MDMA isomer effects: S-MDMA induces stronger head twitches (psychedelic proxy) via serotonin release, and increases dendritic spines in male mice but not females; R-MDMA has somewhat different effects.Sex-specific drug responses: In mice, females show stronger psychedelic effects (head twitches) from psilocybin and DOI at the same dose, but males exhibit greater post-acute benefits like reduced opioid withdrawal.Psilocybin in opioid addiction models: A single dose reduces place preference for oxycodone and withdrawal symptoms in male mice more than females, with opposite spine density effects in reward-related brain areas.Mechanisms beyond 5-HT2A: Psychedelics involve other receptors like metabotropic glutamate receptors, forming dimers with 5-HT2A to enable dual signaling pathways; effects in subcortical regions like nucleus accumbens are 5-HT2A-independent.Clinical implications: Street MDMA may vary in S/R ratios, affecting experiences; clinical trials often use racemic mixtures without weight-adjusted dosing, potentially missing sex differences.ABOUT THE GUEST: Javier Gonzalez-Maeso, PhD is a professor of pharmacology and toxicology at Virginia Commonwealth University, with a PhD in medicine from Spain focused on G-protein coupled receptors and human brain studies in depression and addiction.RELATED EPISODE:M&M 230 | Psilocybin & MDMA: Inflammation, Stress & Brain-Body Communication | Michael WheelerSupport the showHealth Products by M&M Partners: SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off. Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts
We have covered the subject of whether to include the decidual (innermost) layer when closing the uterine incision during cesarean section (CS) on at least 2 episodes. The most recent was in September 2025, when we focused on a published (September 2025) systematic review and meta-analysis from the Green Journal. Back then, we compared those new findings to our prior episode from 2023 on the same matter. Well, we are back at it again with the same subject as there is a new EXPERT REVIEW from the AJOG on hysterotomy closure technique which just came out January 2026. What did these authors conclude? There are also some controversial suggestions made by the authors. Listen in for details. 1. Antoine C, Meyer JA, Silverstein J, Buldo-Licciardi J, Lyu C, Timor-Tritsch IE. Endometrium-Free Closure Technique During Cesarean Delivery for Reducing the Risk of Niche Formation and Placenta Accreta Spectrum Disorders. Obstet Gynecol. 2025 Jun 1;145(6):674-682. doi: 10.1097/AOG.0000000000005813. Epub 2025 Jan 9. PMID: 39787602. 2. Gialdini, Celina et al.Evidence-based surgical procedures to optimize caesarean outcomes: an overview of systematic reviews. eClinicalMedicine- Lancet (June 2024), Volume 72, 102632 3. Dahlke, Joshua D. MD; Mendez-Figueroa, Hector MD; Maggio, Lindsay MD, MPH; Sperling, Jeffrey D. MD, MS; Chauhan, Suneet P. MD, Hon DSc; Rouse, Dwight J. MD. The Case for Standardizing Cesarean Delivery Technique: Seeing the Forest for the Trees. Obstetrics & Gynecology 136(5):p 972-980, November 2020. | DOI: 10.1097/AOG.0000000000004120 4. Antoine C, Timor-Tritsch IE, Bujold E, Young BK, Reece EA. Endometrium-free closure technique for hysterotomy incision at cesarean delivery. Am J Obstet Gynecol. 2026 Jan;233(6S):S103-S114. doi: 10.1016/j.ajog.2025.07.009. PMID: 41485813.
In this episode of the Epigenetics Podcast, we talked with Peggy Farnham from the Keck School of Medicine at USC about her work on establishing the ChIP Method in mammalian cells. In this episode, we dive into the relationship between transcription factors, chromatin dynamics, and gene expression with Professor Peggy Farnham from the Keck School of Medicine at USC. Professor Farnham shares her profound insights into how her groundbreaking research has reshaped our understanding of gene regulation and its implications in cancer. We explore how she has been a pioneer in mapping the genome-wide landscape of regulatory proteins, illuminating the molecular logic behind transcriptional control and its disruption in cancer biology. The interview starts with her instrumental role in adapting chromatin immunoprecipitation (ChIP) technology from yeast to human cells. Professor Farnham reflects on the technical challenges she faced during this transition, such as the quest for visibility of signals in mammalian systems. Her ability to innovate and troubleshoot challenges led to significant advancements in techniques that allow for the rapid identification of transcription factor binding sites, fundamentally changing the landscape of epigenetic research. As the discussion progresses, we learn about Professor Farnham's active involvement in the ENCODE project, where she contributed to high-resolution mapping of transcription factors and regulatory elements in human cells. She articulates her appreciation for collaborative efforts in science, highlighting how working within a consortium harnesses the collective expertise of diverse research groups. This collaboration not only bolstered the credibility of the data produced but also propelled the field forward in understanding the complexity of gene regulation. Through her participation in various projects, such as the Psyc-ENCODE consortium and the Roadmap Epigenome Mapping Consortium, Professor Farnham shares insights into her investigation of epigenetic variations, particularly in relation to complex disorders like schizophrenia. Her findings underscore the nuances of enhancer variability among individuals and the implications for understanding disease mechanisms, thereby advancing our knowledge of genetic regulation and its contributions to diverse biological outcomes. Moreover, the episode highlights Professor Farnham's reflective understanding of emerging technologies in the field. She discusses the evolution of methods that allow researchers to investigate gene regulation at single-cell resolution, recognizing the significant implications these innovations have for our comprehension of cellular differentiation and the transcriptional landscape. References Weinmann AS, Bartley SM, Zhang T, Zhang MQ, Farnham PJ. Use of chromatin immunoprecipitation to clone novel E2F target promoters. Molecular and Cellular Biology. 2001 Oct;21(20):6820-6832. DOI: 10.1128/mcb.21.20.6820-6832.2001. PMID: 11564866; PMCID: PMC99859. Wells J, Farnham PJ. Characterizing transcription factor binding sites using formaldehyde crosslinking and immunoprecipitation. Methods (San Diego, Calif.). 2002 Jan;26(1):48-56. DOI: 10.1016/s1046-2023(02)00007-5. PMID: 12054904. Rhie SK, Schreiner S, Witt H, et al. Using 3D epigenomic maps of primary olfactory neuronal cells from living individuals to understand gene regulation. Science Advances. 2018 Dec;4(12):eaav8550. DOI: 10.1126/sciadv.aav8550. PMID: 30555922; PMCID: PMC6292713. Tak YG, Hung Y, Yao L, et al. Effects on the transcriptome upon deletion of a distal element cannot be predicted by the size of the H3K27Ac peak in human cells. Nucleic Acids Research. 2016 May;44(9):4123-4133. DOI: 10.1093/nar/gkv1530. PMID: 26743005; PMCID: PMC4872074. Related Episodes The Effect of lncRNAs on Chromatin and Gene Regulation (John Rinn) CpG Islands, DNA Methylation, and Disease (Sir Adrian Bird) The Future of Protein–DNA Mapping (Mitch Guttman) MLL Proteins in Mixed-Lineage Leukemia (Yali Dou) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com
Nutritional rickets is caused by a vitamin D deficiency, and people figured out two ways to treat it before we even knew what vitamin D was. Research: “Oldest UK case of rickets in Neolithic Tiree skeleton.” 9/10/2015. https://www.bbc.com/news/uk-scotland-glasgow-west-34208976 Carpenter, Kenneth J. “Harriette Chick and the Problem of Rickets.” The Journal of Nutrition, Volume 138, Issue 5, 827 – 832 Chesney, Russell W. “New thoughts concerning the epidemic of rickets: was the role of alum overlooked?.” Pediatric Nephrology. (2012) 27:3–6. DOI 10.1007/s00467-011-2004-9. Craig, Wallace and Morris Belkin. “The Prevention and Cure of Rickets.” The Scientific Monthly , May, 1925, Vol. 20, No. 5 (May, 1925). Via JSTOR. https://www.jstor.org/stable/7260 Davidson, Tish. "Rickets." The Gale Encyclopedia of Medicine, edited by Jacqueline L. Longe, 6th ed., vol. 7, Gale, 2020, pp. 4485-4487. Gale OneFile: Health and Medicine, link.gale.com/apps/doc/CX7986601644/GPS?u=mlin_n_melpub&sid=bookmark-GPS&xid=811f7e02. Accessed 7 Jan. 2026. Friedman, Aaron. “A brief history of rickets.” Pediatric Nephrology (2020) 35:1835–1841. https://doi.org/10.1007/s00467-019-04366-9 Hawkes, Colin P, and Michael A Levine. “A painting of the Christ Child with bowed legs: Rickets in the Renaissance.” American journal of medical genetics. Part C, Seminars in medical genetics vol. 187,2 (2021): 216-218. doi:10.1002/ajmg.c.31894 Ihde, Aaron J. “Studies on the History of Rickets. I: Recognition of Rickets as a Deficiency Disease.” Pharmacy in History, 1974, Vol. 16, No. 3 (1974). https://www.jstor.org/stable/41108858 Ihde, Aaron J. “Studies on the History of Rickets. II : The Roles of Cod Liver Oil and Light.” Pharmacy in History, 1975, Vol. 17, No. 1 (1975). https://www.jstor.org/stable/41108885 Newton, Gil. “Diagnosing Rickets in Early Modern England: Statistical Evidence and Social Response.” Social History of Medicine Vol. 35, No. 2 pp. 566–588. https://academic.oup.com/shm/article/35/2/566/6381535 O'Riordan, Jeffrey L H, and Olav L M Bijvoet. “Rickets before the discovery of vitamin D.” BoneKEy reports vol. 3 478. 8 Jan. 2014, doi:10.1038/bonekey.2013.212. Palm, T. “Etiology of Rickets.” Br Med J 1888; 2 doi: https://doi.org/10.1136/bmj.2.1457.1247 (Published 01 December 1888) Rajakumar, Kumaravel and Stephen B. Thomas. “Reemerging Nutritional Rickets: A Historical Perspective.” Arch Pediatr Adolesc Med. Published Online: April 2005 2005;159;(4):335-341. doi:10.1001/archpedi.159.4.335 Swinburne, Layinka M. “Rickets and the Fairfax family receipt books.” Journal of the Royal Society of Medicine. Vol. 99. August 2006. Tait, H. P.. “Daniel Whistler and His Contribution to Pædiatrics.” Edinburgh Medical Journal vol. 53,6 (1946): 325–330. Warren, Christian. “No Magic Bolus: What the History of Rickets and Vitamin D Can Teach Us About Setting Standards.” Journal of Adolescent Health. 66 (2020) 379e380. https://www.jahonline.org/article/S1054-139X(20)30038-0/pdf Wheeler, Benjamin J et al. “A Brief History of Nutritional Rickets.” Frontiers in endocrinology vol. 10 795. 14 Nov. 2019, doi:10.3389/fendo.2019.00795 World Health Organization. “The Magnitude and Distribution of Nutritoinal Rickets: Disease Burden in Infants, Children, and Adolescents.” 2019. Via JSTOR. https://www.jstor.org/stable/resrep27899.7 Zhang, M., Shen, F., Petryk, A., Tang, J., Chen, X., & Sergi, C. (2016). “English Disease”: Historical Notes on Rickets, the Bone–Lung Link and Child Neglect Issues. Nutrients, 8(11), 722. https://doi.org/10.3390/nu8110722 See omnystudio.com/listener for privacy information.
Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-469 Overview: Tune in to hear how self-collected vaginal human papillomavirus (HPV) testing has potential to expand access to cervical cancer screening and reduce barriers for your patients. This episode reviews cervical cancer screening guidelines, follow-up recommendations, and how to consider offering self-collection as an option to increase screening rates and improve preventive care in your practice. Episode resource links: CA CancerJClin.2026;e70041. DOI:10.3322/caac.70041 US Food and Drug Administration (FDA). Device Classification Under Section 513(f)(2)(De Novo). Device for home collection and transport of vaginal specimens by lay users for use in an approved HPV molecular assay. FDA; 2025. FranklySpeaking@pri-med.com The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.
Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-469 Overview: Tune in to hear how self-collected vaginal human papillomavirus (HPV) testing has potential to expand access to cervical cancer screening and reduce barriers for your patients. This episode reviews cervical cancer screening guidelines, follow-up recommendations, and how to consider offering self-collection as an option to increase screening rates and improve preventive care in your practice. Episode resource links: CA CancerJClin.2026;e70041. DOI:10.3322/caac.70041 US Food and Drug Administration (FDA). Device Classification Under Section 513(f)(2)(De Novo). Device for home collection and transport of vaginal specimens by lay users for use in an approved HPV molecular assay. FDA; 2025. FranklySpeaking@pri-med.com The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.
Back in March of 2025, the green journal (obstetrics andgynecology) published A systematic review and meta-analysis on 2 medications (non-hormonal) and their efficacy in menopausal hot flash relief period these medications were Fezolinetant and Elinzanetant. However, the editors have just recently released an “Expression of Concern” about this review. Listen in for details. 1. Menegaz de Almeida, Artur MS; Oliveira, PalomaMS; Lopes, Lucca MD; Leite, Marianna MS; Morbach, Victória MS; Alves Kelly,Francinny MD; Barros, Ítalo MS; Aquino de Moraes, Francisco Cezar MS;Prevedello, Alexandra MD. Fezolinetant and Elinzanetant Therapy for MenopausalWomen Experiencing Vasomotor Symptoms: A Systematic Review and Meta-analysis.Obstetrics & Gynecology 145(3):p 253-261, March 2025. | DOI:10.1097/AOG.00000000000058122. Expression of Concern: Fezolinetant andElinzanetant Therapy for Menopausal Women Experiencing Vasomotor Symptoms: ASystematic Review and Meta-Analysis. Obstetrics & Gynecology():10.1097/AOG.0000000000006180, January 16, 2026. | DOI: 10.1097/AOG.0000000000006180
Smartband-Based Smoking Detection and Real-Time Brief Mindfulness Intervention: Findings from a Feasibility Clinical TrialIn this episode, Dr. Jud examines the groundbreaking results from a feasibility trial exploring the use of smartbands for smoking cessation. This innovative study showcases how wearable technology can detect smoking events in real time and deliver brief mindfulness interventions to address cravings. Dr. Jud discusses the study's design, key findings, and their implications for the future of digital health interventions. Learn how the integration of real-time behavioral data with mindfulness-based techniques holds the potential to transform smoking cessation efforts globally.Reference:Horvath M, Pittman B, O'Malley SS, Grutman A, Khan N, Gueorguieva R, Brewer JA, Garrison KA. Smartband-Based Smoking Detection and Real-Time Brief Mindfulness Intervention: Findings from a Feasibility Clinical Trial. Annals of Medicine. 2024;56(1):2352803. DOI: 10.1080/07853890.2024.2352803Let's connect on Instagram
Join us as we begin our two part discussion of Psychedelic Assisted Psychotherapy and Integration with Dr. Arayan Sarparast of the OHSU Psilocybin Education & Assessment Collaborative for Excellence (PEACE) Clinic and clinical research coordinator Will Lucas. This episode focuses primarily on counseling patients interested in Psychedelic Assisted Psychotherapy and harm reduction strategies when working with patients that have presented to the hospital with altered mental status after ingesting Psychedelic substances. We also discuss medico-legal issues surrounding psilocybin, primarily in the state of Oregon. Stay tuned for part 2 in which we will further dive into integration and psychotherapy after psychedelic experiences. Additional learning materials and resources for this episode can be found at: About Oregon Psilocybin Services:https://www.oregon.gov/oha/ph/preventionwellness/pages/oregon-psilocybin-services.aspxKelan L. Thomas, B.E.S. Robert Jesse, Nicky J. Mehtani, Jennifer M. Mitchell & Brian T. Anderson (2023): Commentary: Evidence-Informed Recommendation to Achieve Approximate Parity in the Allowed Number of Doses for Common Psychedelics, Journal of Psychoactive Drugs, DOI: 10.1080/02791072.2023.2201244Bathje GJ, Majeski E and Kudowor M (2022) Psychedelic integration: An analysis of the concept and its practice.Front. Psychol. 13:824077. doi: 10.3389/fpsyg.2022.824077Carbonaro, T. M., Bradstreet, M. P., Barrett, F. S., MacLean, K. A., Jesse, R., Johnson, M. W., & Griffiths, R. R. (2016). Survey study of challenging experiences after ingesting psilocybin mushrooms: Acute and enduring positive and negative consequences. Journal of Psychopharmacology, 30(12), 1268-1278.For any questions and feedback, please contact us at psychiatryexplored@gmail.com.
Ursodiol (ursodeoxycholic acid) is a prescription bile acid medication used to dissolve cholesterol gallstones, prevent gallstones during rapid weight loss, and treat liver diseases like primary biliary cholangitis (PBC) by reducing toxic bile acids and cholesterol production. It works by changing bile composition, making it less saturated with cholesterol, and is available as oral medication. Of course, it is also the foundational medication for treatment of diagnosed Intrahepatic Cholestasis of Pregnancy (ICP). Does this medication reduce adverse perinatal outcomes? In this episode, we will review a new study from the Green Journal, which will be out in February 2026, examining the recurrence risk for ICP using data from NY. In a patient with prior history of ICP, is there any guidance on monitoring of serum bile acids in the subsequent pregnancy before symptoms develop? We will explain. PLUS we will review the data on whether Ursodiol may hold promise in recurrence prevention or in reduction of adverse outcomes once the condition is diagnosed. Listen in for details. 1. 2019: Chappell LC, Bell JL, Smith A, Linsell L, Juszczak E, Dixon PH, Chambers J, Hunter R, Dorling J, Williamson C, Thornton JG; PITCHES study group. Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES): a randomised controlled trial. Lancet. 2019 Sep 7;394(10201):849-860. doi: 10.1016/S0140-6736(19)31270-X. Epub 2019 Aug 1. PMID: 31378395; PMCID: PMC6739598. https://pubmed.ncbi.nlm.nih.gov/31378395/2. February 08, 2025: Rahim, Mussarat N et al. Pregnancy and the liver. The Lancet. 2021; Volume 405, Issue 10477, 498 – 513 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)02351-1/fulltext3. SMFM CS 53; 20214. Rosenberg, Henri M. MD; Sarker, Minhazur R. MD; Ramos, Gladys A. MD; Bianco, Angela MD; Ferrara, Lauren MD; DeBolt, Chelsea A. MD. Intrahepatic Cholestasis of Pregnancy Recurrence in a Subsequent Pregnancy. Obstetrics & Gynecology 147(2):p 239-241, February 2026. | DOI: 10.1097/AOG.0000000000006033 https://journals.lww.com/greenjournal/fulltext/2026/02000/intrahepatic_cholestasis_of_pregnancy_recurrence.13.aspx5. Ovadia C, Sajous J, Seed PT et al. Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis. Lancet Gastroenterol Hepatol. 2021 Jul;6(7):547-558. doi: 10.1016/S2468-1253(21)00074-1. Epub 2021 Apr 27. PMID: 33915090; PMCID: PMC8192305.6. EASL Clinical Practice Guidelines on the management of liver diseases in pregnancy. European Association for the Study of the Liver; 2023
Exploramos los hallazgos más recientes sobre compresiones manuales versus compresiones mecánicas en la reanimación cardiopulmonar. ¿Qué opción ofrece mejores resultados en pacientes con paro cardíaco? ¿Qué deben saber los proveedores de ACLS hoy?
If you've ever heard me talk about coaching and wondered, "But what IS coaching, exactly?" you're not alone. This episode was inspired by a real conversation in my Facebook group that made me realize a lot of SLPs don't actually know what coaching is and how it can help. (I didn't either before I found it.)So today, I'm breaking down five things I wish every SLP understood about coaching and why it might be the missing piece if your life looks fine on paper, but feels heavy in practice.What You'll LearnI'll explain why coaching is not advice, mentoring, or someone telling you what to doI share how coaching is similar to — and very different from — therapyWe'll talk about how coaching helps you build a life that actually fits your brain, especially if you have ADHDI'll break down why coaching is evidence-based and not “woo”I explain who coaching is actually for and why you don't have to be falling apart to benefitIf This ResonatesIf this episode had you nodding along or thinking, “Oh, that' sounds helpful,” I'd love to talk with you. You don't need a perfectly defined goal. Clarity is something we build together.
Dr. Macy Bolt unpacks a new vestibular diagnosis impacting many older adults. Even if you don't think you're cut out to treat vestibular disorders, after this episode you may find you are! She discusses the diagnosis, differential and clinical tidbits, and how to help these patients, even if you don't typically treat dizziness. DOI:10.3233/VES-190672 Want to make sure you stay up to date in all things Geriatrics in less than 3 minutes every other week? Join thousands of others in our free MMOA Digest Email list - https://institute-of-clinical-excellence.kit.com/a3837f54b7
Smartband-Based Automatic Smoking Detection and Real-Time Mindfulness Intervention: Protocol for a Feasibility TrialJoin Dr. Jud in this episode as he dives into the innovative intersection of wearable technology, mindfulness, and smoking cessation. This episode explores a cutting-edge study protocol designed to evaluate the feasibility of using a smartband and smartphone app for real-time smoking detection and intervention. Learn how mindfulness exercises like "RAIN" are being tailored to moments of craving, leveraging data-driven insights to support smokers on their journey to quit. Dr. Jud discusses the potential implications of this technology for public health and addiction treatment, emphasizing how behavioral science and technology can converge to create impactful solutions.Reference:Horvath M, Grutman A, O'Malley SS, Gueorguieva R, Khan N, Brewer JA, Garrison KA. Smartband-Based Automatic Smoking Detection and Real-Time Mindfulness Intervention: Protocol for a Feasibility Trial. JMIR Research Protocols. 2021;10(10):e32521. DOI: 10.2196/32521Let's connect on Instagram
This week we review a follow-up work from the team at USC and Children's LA led by Dr. Yaniv Bar-Cohen on a novel micropacemaker. How has the device changed and improved over the past 3-5 years since his last visit to Pediheart? What are some of the difficulties of designing a device that is both stable on the epicardium but not inclined to develop inflammation? Why did the team move from a screw in eletrode model to a different design? What applications could this device have both for infants but also adults? Dr. Bar-Cohen shares his deep knowledge of both electrophysiology and device design this week.DOI: 10.1016/j.hrthm.2025.01.036For those interested in stepping back in time to hear Dr. Bar-Cohen's first description of an earlier version of this novel pacemaker, here is the link from 2018:https://podcasts.apple.com/us/podcast/pediheart-podcast-26-novel-means-of-epicardial/id1341472214?i=1000498801107
Discussion of things literally or figuratively unearthed in the last quarter of 2025 continues. It begins with potpourri then covers tools, Neanderthals, edibles and potables, art, shipwrecks, medical finds, and repatriations. Research: Abdallah, Hanna. “Famous Easter Island statues were created without centralized management.” PLOS. Via EurekAlert. 11/26/2025. https://www.eurekalert.org/news-releases/1106805 Abdallah, Hannah. “Early humans butchered elephants using small tools and made big tools from their bones.” PLOS. Via EurekAlert. 10/8/2025. https://www.eurekalert.org/news-releases/1100481 Abdallah, Hannah. “Researchers uncover clues to mysterious origin of famous Hjortspring boat.” EurekAlert. 10/12/2025. https://www.eurekalert.org/news-releases/1108323 Archaeology Magazine. “Medieval Hoard of Silver and Pearls Discovered in Sweden.” https://archaeology.org/news/2025/10/14/medieval-hoard-of-silver-and-pearls-discovered-in-sweden/ Archaeology Magazine. “Possible Trepanation Tool Unearthed in Poland.” 11/13/2025. https://archaeology.org/news/2025/11/13/possible-trepanation-tool-unearthed-in-poland/ Arkeologerna. “Rare 5,000-year-old dog burial unearthed in Sweden.” 12/15/2025. https://news.cision.com/se/arkeologerna/r/rare-5-000-year-old-dog-burial-unearthed-in-sweden,c4282014 Arnold, Paul. “Ancient ochre crayons from Crimea reveal Neanderthals engaged in symbolic behaviors.” Phys.org. 10/30/2025. https://phys.org/news/2025-10-ancient-ochre-crayons-crimea-reveal.html Arnold, Paul. “Dating a North American rock art tradition that lasted 175 generations.” Phys.org. 11/28/2025. https://phys.org/news/2025-11-dating-north-american-art-tradition.html Bassi, Margherita. “A Single Gene Could Have Contributed to Neanderthals’ Extinction, Study Suggests.” Smithsonian. 10/30/2025. https://www.smithsonianmag.com/smart-news/a-neanderthal-gene-variant-related-to-red-blood-cells-may-have-contributed-to-their-extinction-180987586/ Benjamin Pohl, Chewing over the Norman Conquest: the Bayeux Tapestry as monastic mealtime reading, Historical Research, 2025;, htaf029, https://doi.org/10.1093/hisres/htaf029 Benzine, Vittoria. “Decoded Hieroglyphics Reveal Female Ruler of Ancient Maya City.” ArtNet. 10/27/2025. https://news.artnet.com/art-world/foundation-stone-maya-coba-woman-ruler-2704521 Berdugo, Sophie. “Easter Island statues may have 'walked' thanks to 'pendulum dynamics' and with as few as 15 people, study finds.” LiveScience. 10/19/2025. https://www.livescience.com/archaeology/easter-island-statues-may-have-walked-thanks-to-pendulum-dynamics-and-with-as-few-as-15-people-study-finds Billing, Lotte. “Fingerprint of ancient seafarer found on Scandinavia’s oldest plank boat.” EurekAlert. 10/12/2025. https://www.eurekalert.org/news-releases/1109361 Brhel, John. “Rats played major role in Easter Island’s deforestation, study reveals.” EurekAlert. 11/17/2025. https://www.eurekalert.org/news-releases/1106361 Caldwell, Elizabeth. “9 more individuals unearthed at Oaklawn could be 1921 Tulsa Race Massacre victims.” Tulsa Public Radio. 11/6/2025. https://www.publicradiotulsa.org/local-regional/2025-11-06/9-more-individuals-unearthed-at-oaklawn-could-be-1921-tulsa-race-massacre-victims Clark, Gaby. “Bayeux Tapestry could have been originally designed as mealtime reading for medieval monks.” Phys.org. 12/15/2025. https://phys.org/news/2025-12-bayeux-tapestry-mealtime-medieval-monks.html#google_vignette Cohen, Alina. “Ancient Olive Oil Processing Complex Unearthed in Tunisia.” Artnet. 11/21/2025. https://news.artnet.com/art-world/ancient-olive-oil-complex-tunisia-2717795 Cohen, Alina. “MFA Boston Restores Ownership of Historic Works by Enslaved Artist.” ArtNet. 10/30/2025. https://news.artnet.com/art-world/mfa-boston-david-drake-jars-restitution-2706594 Fergusson, Rachel. “First DNA evidence of Black Death in Edinburgh discovered on teeth of excavated teenage skeleton.” The Scotsman. 11/5/2025. https://www.scotsman.com/news/first-dna-evidence-black-death-edinburgh-discovered-teeth-excavated-teenage-skeleton-5387741 Folorunso, Caleb et al. “MOWAA Archaeology Project: Enhancing Understanding of Benin City’s Historic Urban Development and Heritage through Pre-Construction Archaeology.” Antiquity (2025): 1–10. Web. Griffith University. “Rare stone tool cache tells story of trade and ingenuity.” 12/2/2025. https://news.griffith.edu.au/2025/12/02/rare-stone-tool-cache-tells-story-of-trade-and-ingenuity/ Han, Yu et al. “The late arrival of domestic cats in China via the Silk Road after 3,500 years of human-leopard cat commensalism.” Cell Genomics, Volume 0, Issue 0, 101099. https://www.cell.com/cell-genomics/fulltext/S2666-979X(25)00355-6 Hashemi, Sara. “A Volcanic Eruption in 1345 May Have Triggered a Chain of Events That Brought the Black Death to Europe.” Smithsonian. 12/8/2025. https://www.smithsonianmag.com/smart-news/a-volcanic-eruption-in-1345-may-have-triggered-a-chain-of-events-taht-brought-the-black-death-to-europe-180987803/ Hjortkjær, Simon Thinggaard. “Mysterious signs on Teotihuacan murals may reveal an early form of Uto-Aztecan language.” PhysOrg. 10/6/2025. https://phys.org/news/2025-10-mysterious-teotihuacan-murals-reveal-early.html Institut Pasteur. “Study suggests two unsuspected pathogens struck Napoleon's army during the retreat from Russia in 1812.” Via EurekAlert. 10/24/2025. https://www.eurekalert.org/news-releases/1102613 Jones, Sam. “Shells found in Spain could be among oldest known musical instruments.” The Guardian. 12/2/2025. https://www.theguardian.com/science/2025/dec/02/neolithic-conch-like-shell-spain-catalonia-discovery-musical-instruments Kasal, Krystal. “Pahon Cave provides a look into 5,000 years of surprisingly stable Stone Age tool use.” Phys.org. 12/16/2025. https://phys.org/news/2025-12-pahon-cave-years-stable-stone.html Kristiansen, Nina. “Eight pages bound in furry seal skin may be Norway's oldest book.” Science Norway. 11/3/2025. https://www.sciencenorway.no/cultural-history-culture-history/eight-pages-bound-in-furry-seal-skin-may-be-norways-oldest-book/2571496 Kuta, Sarah. “109-Year-Old Messages in a Bottle Written by Soldiers Heading to Fight in World War I Discovered on Australian Beach.” Smithsonian. 11/6/2025. https://www.smithsonianmag.com/smart-news/109-year-old-messages-in-a-bottle-written-by-soldiers-heading-to-fight-in-world-war-i-discovered-on-australian-beach-180987649/ Kuta, Sarah. “A Storm Battered Western Alaska, Scattering Thousands of Indigenous Artifacts Across the Sand.” Smithsonian. 10/31/2025. https://www.smithsonianmag.com/smart-news/a-storm-battered-western-alaska-scattering-thousands-of-indigenous-artifacts-across-the-sand-180987606/ Kuta, Sarah. “Archaeologists Unearth More Than 100 Projectiles From an Iconic Battlefield in Scotland.” Smithsonian. 11/5/2025. https://www.smithsonianmag.com/smart-news/archaeologists-unearth-more-than-100-projectiles-from-an-iconic-battlefield-in-scotland-180987641/ Kuta, Sarah. “Hundreds of Mysterious Victorian-Era Shoes Are Washing Up on a Beach in Wales. Nobody Knows Where They Came From.” Smithsonian. 1/5/2026. https://www.smithsonianmag.com/smart-news/hundreds-of-mysterious-victorian-era-shoes-are-washing-up-on-a-beach-in-wales-nobody-knows-where-they-came-from-180987943/ Lawson-Tancred, Jo. “Golden ‘Tudor Heart’ Necklace Sheds New Light on Henry VIII’s First Marriage.” Artnet. 10/14/2025. https://news.artnet.com/art-world/tudor-heart-pendant-british-museum-fundraiser-2699544 Lawson-Tancred, Jo. “Long-Overlooked Black Veteran Identified in Rare 19th-Century Portrait.” ArtNet. 10/27/2025. https://news.artnet.com/art-world/black-veteran-thomas-phillips-portrait-identified-2704721 Lipo CP, Hunt TL, Pakarati G, Pingel T, Simmons N, Heard K, et al. (2025) Megalithic statue (moai) production on Rapa Nui (Easter Island, Chile). PLoS One 20(11): e0336251. https://doi.org/10.1371/journal.pone.0336251 Lipo, Carl P. and Terry L. Hunt. “The walking moai hypothesis: Archaeological evidence, experimental validation, and response to critics.” Journal of Archaeological Science. Volume 183, November 2025, 106383. https://www.sciencedirect.com/science/article/abs/pii/S0305440325002328 Lock, Lisa. “Pre-construction archaeology reveals Benin City's historic urban development and heritage.” 10/29/2025. https://phys.org/news/2025-10-pre-archaeology-reveals-benin-city.html#google_vignette Lock, Lisa. “Pre-construction archaeology reveals Benin City's historic urban development and heritage.” Antiquity. Via PhysOrg. 10/29/2025. https://phys.org/news/2025-10-pre-archaeology-reveals-benin-city.html#google_vignette Lynley A. Wallis et al, An exceptional assemblage of archaeological plant fibres from Windmill Way, southeast Cape York Peninsula, Australian Archaeology (2025). DOI: 10.1080/03122417.2025.2574127 Lyon, Devyn. “Oaklawn Cemetery excavation brings investigators closer to identifying Tulsa Race Massacre victims.” Fox 23. 11/6/2025. https://www.fox23.com/news/oaklawn-cemetery-excavation-brings-investigators-closer-to-identifying-tulsa-race-massacre-victims/article_67c3a6b7-2acc-44cb-93ce-3d3d0c288eca.html Marquard, Bryan. “Bob Shumway, last known survivor of the deadly Cocoanut Grove nightclub fire, dies at 101.” 11/12/2025. https://www.bostonglobe.com/2025/11/12/metro/bob-shumway-101-dies-was-last-known-cocoanut-grove-fire-survivor/?event=event12 Marta Osypińska et al, A centurion's monkey? Companion animals for the social elite in an Egyptian port on the fringes of the Roman Empire in the 1st and 2nd c. CE, Journal of Roman Archaeology (2025). DOI: 10.1017/s1047759425100445 Merrington, Andrew. “Extensive dog diversity millennia before modern breeding practices.” University of Exeter. 11/13/2025. https://news.exeter.ac.uk/faculty-of-humanities-arts-and-social-sciences/archaeology-and-history/extensive-dog-diversity-millennia-before-modern-breeding-practices/ Morris, Steven. “Linguists start compiling first ever complete dictionary of ancient Celtic.” The Guardian. 12/8/2025. https://www.theguardian.com/science/2025/dec/08/linguists-start-compiling-first-ever-complete-dictionary-of-ancient-celtic Museum of Fine Arts, Boston. “Museum of Fine Arts, Boston, Resolves Ownership of Works by Enslaved Artist David Drake.” 10/29/2025. https://www.mfa.org/press-release/david-drake-ownership-resolution Narcity. “Niagara has a 107-year-old shipwreck lodged above the Falls and it just moved.” https://www.narcity.com/niagara-falls-shipwreck-iron-scow-moved-closer-to-the-falls Newcomb, Tim. “A 76-Year-Old Man Went On a Hike—and Stumbled Upon a 1,500-Year Old Trap.” Popular Mechanics. 11/21/2025. https://www.popularmechanics.com/science/archaeology/a69441460/reindeer-trap/ Nordin, Gunilla. “Ancient wolves on remote Baltic Sea island reveal link to prehistoric humans.” Stockholm University. Via EurekAlert. 11/24/2025. https://www.eurekalert.org/news-releases/1106807 Oster, Sandee. “DNA confirms modern Bo people are descendants of ancient Hanging Coffin culture.” Phys.org. 12/6/2025. https://phys.org/news/2025-12-dna-modern-bo-people-descendants.html Oster, Sandee. “Rare disease possibly identified in 12th century child's skeletal remains.” PhysOrg. 10/10/2025. https://phys.org/news/2025-10-rare-disease-possibly-12th-century.html Osuh, Chris and Geneva Abdul. “Lost grave of daughter of Black abolitionist Olaudah Equiano found by A-level student.” The Guardian. 11/1/2025. https://www.theguardian.com/uk-news/2025/nov/01/lost-grave-daughter-black-abolitionist-olaudah-equiano-found-by-a-level-student Silvia Albizuri et al, The oldest mule in the western Mediterranean. The case of the Early Iron Age in Hort d'en Grimau (Penedès, Barcelona, Spain), Journal of Archaeological Science: Reports (2026). DOI: 10.1016/j.jasrep.2025.105506 Skok, Phoebe. “Ancient shipwrecks rewrite the story of Iron Age trade.” PhysOrg. 10/14/2025. https://phys.org/news/2025-10-ancient-shipwrecks-rewrite-story-iron.html The History Blog. “600-year-old Joseon ship recovered from seabed.” 11/15/2025. https://www.thehistoryblog.com/archives/74652 The History Blog. “Ancient pleasure barge found off Alexandria coast.” 12/9/2025. https://www.thehistoryblog.com/archives/74860 The History Blog. “Charred Byzantine bread loves stamped with Christian imagery found in Turkey.” 10/13/2025. https://www.thehistoryblog.com/archives/74352 The History Blog. “Early medieval silver treasure found in Stockholm.” 10/12/2025. https://www.thehistoryblog.com/archives/74343 The History Blog. “Roman amphora with sardines found in Switzerland.” 12/15/2025. https://www.thehistoryblog.com/archives/74904 The Straits Times. “Wreck of ancient Malay vessel discovered on Pulau Melaka.” 10/31/2025. https://www.straitstimes.com/asia/se-asia/wreck-of-ancient-malay-vessel-discovered-on-pulau-melaka Thompson, Sarah. “The forgotten daughter: Eliza Monroe Hay’s story revealed in her last letters.” W&M News. 9/30/2025. https://news.wm.edu/2025/09/30/the-forgotten-daughter-eliza-monroes-story-revealed-in-her-last-letters/ Tuhkuri, Jukka. “Why Did Endurance Sink?” Polar Record 61 (2025): e23. Web. https://www.cambridge.org/core/journals/polar-record/article/why-did-endurance-sink/6CC2C2D56087035A94DEB50930B81980 Universitat de Valencia. “The victims of the Pompeii eruption wore heavy wool cloaks and tunics, suggesting different environmental conditions in summer.” 12/3/2025. https://www.uv.es/uvweb/uv-news/en/news/victims-pompeii-eruption-wore-heavy-wool-cloaks-tunics-suggesting-different-environmental-conditions-summer-1285973304159/Novetat.html?id=1286464337848&plantilla=UV_Noticies/Page/TPGDetaillNews University of Glasgow. “Archaeologists recover hundreds of Jacobite projectiles in unexplored area of Culloden.” 10/30/2025. https://www.gla.ac.uk/news/headline_1222736_en.html University of Vienna. “Neanderthal DNA reveals ancient long-distance migrations.” 10/29/2025. https://www.univie.ac.at/en/news/detail/neanderthal-dna-reveals-ancient-long-distance-migrations Zhou, H., Tao, L., Zhao, Y. et al. Exploration of hanging coffin customs and the bo people in China through comparative genomics. Nat Commun 16, 10230 (2025). https://doi.org/10.1038/s41467-025-65264-3 Zinin, Andrew. “Ancient humans mastered fire-making 400,000 years ago, study shows.” Phys.org. 10/10/2025. https://phys.org/news/2025-12-ancient-humans-mastered-years.html See omnystudio.com/listener for privacy information.
Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-vaccine-update Overview: In this episode, we discuss the recently updated US childhood vaccine schedule, including key changes and the rationale behind these recommendations. We also talk about the risks of vaccine-preventable illnesses and review vaccine efficacy and safety considerations—helping you navigate evolving guidance and protect patients in primary care. Episode resource links: RSV: Pediatrics. 2024. Curns AT, Rha B, Lively JY, et al. J Infect Dis. 2022 Aug 15;226(Suppl 2):S154-S163. doi: 10.1093/infdis/jiac120 Hep B: N Engl J Med 2019;380:2041-2050 DOI: 10.1056/NEJMra181047 Clin Infect Dis. 2021 Nov 2;73(9):e3317-e3323. doi: 10.1093/cid/ciaa898. Meningococcal Vaccines and disease: MMWR. Morbidity and Mortality Weekly Report. 2024. Collins JP, Crowe SJ, Ortega-Sanchez IR, et al. Vaccine. 2019. Wang B, Santoreneos R, Giles L, Haji Ali Afzali H, Marshall H. Guest: Jillian Joseph, MPAS, PA-C Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.
Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-vaccine-update Overview: In this episode, we discuss the recently updated US childhood vaccine schedule, including key changes and the rationale behind these recommendations. We also talk about the risks of vaccine-preventable illnesses and review vaccine efficacy and safety considerations—helping you navigate evolving guidance and protect patients in primary care. Episode resource links: RSV: Pediatrics. 2024. Curns AT, Rha B, Lively JY, et al. J Infect Dis. 2022 Aug 15;226(Suppl 2):S154-S163. doi: 10.1093/infdis/jiac120 Hep B: N Engl J Med 2019;380:2041-2050 DOI: 10.1056/NEJMra181047 Clin Infect Dis. 2021 Nov 2;73(9):e3317-e3323. doi: 10.1093/cid/ciaa898. Meningococcal Vaccines and disease: MMWR. Morbidity and Mortality Weekly Report. 2024. Collins JP, Crowe SJ, Ortega-Sanchez IR, et al. Vaccine. 2019. Wang B, Santoreneos R, Giles L, Haji Ali Afzali H, Marshall H. Guest: Jillian Joseph, MPAS, PA-C Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.
BUFFALO, NY – January 13, 2026 – A new #hypothesis article was #published in Oncotarget (Volume 17) on January 3, 2026, titled “Hypothesis: HPV E6 and COVID spike proteins cooperate in targeting tumor suppression by p53.” Written by Wafik S. El-Deiry, Oncotarget Editor-in-Chief, from The Warren Alpert Medical School of Brown University and from Lifespan Health System and Brown University, the paper proposes that two viral proteins, HPV E6 and SARS-CoV-2 spike, could jointly reduce the activity of p53, a protein that helps protect cells from becoming cancerous. HPV is already known to drive several cancers, and the hypothesis suggests that additional pressure on p53 could matter for cancer risk or recurrence in some settings. HPV can promote cancer development in part by using its E6 protein, together with a human partner protein called E6-AP, to drive the downregulation of p53. When p53 is weakened, damaged cells may be more likely to survive and continue growing. The new hypothesis asks whether SARS-CoV-2 viral influence could further reduce p53 function in people already affected by HPV. The article highlights studies suggesting that the SARS-CoV-2 spike protein may suppress p53 activity and discusses observations that have raised questions about cancer outcomes after COVID-19 infection or vaccination in certain contexts. It also notes that a search of the literature did not identify clear evidence of direct molecular cooperation between HPV and COVID-19 in suppressing p53, which underscores the need for further studies. “I listened to an interview (https://www.youtube.com/watch?v=tnVMjp9mCA0&t=2s) of Dr. Patrick Soon-Shiong by Chris Cuomo where I learned about a patient named Jim Johnson with a history of HPV-related head and neck cancer who by 2022 had survived his HPV-related cancer for 7 years and then he took the COVID vaccine.” To investigate the presented hypothesis, Dr. El-Deiry proposes epidemiological studies that analyze cancer incidence and recurrence in HPV-positive groups with prior SARS-CoV-2 infection or COVID mRNA vaccination. It also proposes laboratory studies to assess whether HPV E6 and SARS-CoV-2 spike combined reduce p53 function more than either factor alone. Overall, the hypothesis was formulated to focus attention on an HPV and SARS-CoV-2 shared biological target, p53, and to encourage careful studies that separate coincidence from causation. By outlining specific approaches, it aims to help researchers evaluate whether combined viral pressures on tumor-suppressor pathways could contribute to cancer progression. DOI - https://doi.org/10.18632/oncotarget.28823 Correspondence to - Wafik S. El-Deiry - wafik@brown.edu Abstract video - https://www.youtube.com/watch?v=2GJVmpG4fPk Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28823 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, HPV, COVID, p53, spike To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us on social media: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM
The show's coverage of things literally or figuratively unearthed in the last quarter of 2025 begins with updates, books and letters, animals, and just one exhumation. Research: Abdallah, Hanna. “Famous Easter Island statues were created without centralized management.” PLOS. Via EurekAlert. 11/26/2025. https://www.eurekalert.org/news-releases/1106805 Abdallah, Hannah. “Early humans butchered elephants using small tools and made big tools from their bones.” PLOS. Via EurekAlert. 10/8/2025. https://www.eurekalert.org/news-releases/1100481 Abdallah, Hannah. “Researchers uncover clues to mysterious origin of famous Hjortspring boat.” EurekAlert. 10/12/2025. https://www.eurekalert.org/news-releases/1108323 Archaeology Magazine. “Medieval Hoard of Silver and Pearls Discovered in Sweden.” https://archaeology.org/news/2025/10/14/medieval-hoard-of-silver-and-pearls-discovered-in-sweden/ Archaeology Magazine. “Possible Trepanation Tool Unearthed in Poland.” 11/13/2025. https://archaeology.org/news/2025/11/13/possible-trepanation-tool-unearthed-in-poland/ “Rare 5,000-year-old dog burial unearthed in Sweden.” 12/15/2025. https://news.cision.com/se/arkeologerna/r/rare-5-000-year-old-dog-burial-unearthed-in-sweden,c4282014 Arnold, Paul. “Ancient ochre crayons from Crimea reveal Neanderthals engaged in symbolic behaviors.” Phys.org. 10/30/2025. https://phys.org/news/2025-10-ancient-ochre-crayons-crimea-reveal.html Arnold, Paul. “Dating a North American rock art tradition that lasted 175 generations.” Phys.org. 11/28/2025. https://phys.org/news/2025-11-dating-north-american-art-tradition.html Bassi, Margherita. “A Single Gene Could Have Contributed to Neanderthals’ Extinction, Study Suggests.” Smithsonian. 10/30/2025. https://www.smithsonianmag.com/smart-news/a-neanderthal-gene-variant-related-to-red-blood-cells-may-have-contributed-to-their-extinction-180987586/ Benjamin Pohl, Chewing over the Norman Conquest: the Bayeux Tapestry as monastic mealtime reading, Historical Research, 2025;, htaf029, https://doi.org/10.1093/hisres/htaf029 Benzine, Vittoria. “Decoded Hieroglyphics Reveal Female Ruler of Ancient Maya City.” ArtNet. 10/27/2025. https://news.artnet.com/art-world/foundation-stone-maya-coba-woman-ruler-2704521 Berdugo, Sophie. “Easter Island statues may have 'walked' thanks to 'pendulum dynamics' and with as few as 15 people, study finds.” LiveScience. 10/19/2025. https://www.livescience.com/archaeology/easter-island-statues-may-have-walked-thanks-to-pendulum-dynamics-and-with-as-few-as-15-people-study-finds Billing, Lotte. “Fingerprint of ancient seafarer found on Scandinavia’s oldest plank boat.” EurekAlert. 10/12/2025. https://www.eurekalert.org/news-releases/1109361 Brhel, John. “Rats played major role in Easter Island’s deforestation, study reveals.” EurekAlert. 11/17/2025. https://www.eurekalert.org/news-releases/1106361 Caldwell, Elizabeth. “9 more individuals unearthed at Oaklawn could be 1921 Tulsa Race Massacre victims.” Tulsa Public Radio. 11/6/2025. https://www.publicradiotulsa.org/local-regional/2025-11-06/9-more-individuals-unearthed-at-oaklawn-could-be-1921-tulsa-race-massacre-victims Clark, Gaby. “Bayeux Tapestry could have been originally designed as mealtime reading for medieval monks.” Phys.org. 12/15/2025. https://phys.org/news/2025-12-bayeux-tapestry-mealtime-medieval-monks.html#google_vignette Cohen, Alina. “Ancient Olive Oil Processing Complex Unearthed in Tunisia.” Artnet. 11/21/2025. https://news.artnet.com/art-world/ancient-olive-oil-complex-tunisia-2717795 Cohen, Alina. “MFA Boston Restores Ownership of Historic Works by Enslaved Artist.” ArtNet. 10/30/2025. https://news.artnet.com/art-world/mfa-boston-david-drake-jars-restitution-2706594 Fergusson, Rachel. “First DNA evidence of Black Death in Edinburgh discovered on teeth of excavated teenage skeleton.” The Scotsman. 11/5/2025. https://www.scotsman.com/news/first-dna-evidence-black-death-edinburgh-discovered-teeth-excavated-teenage-skeleton-5387741 Folorunso, Caleb et al. “MOWAA Archaeology Project: Enhancing Understanding of Benin City’s Historic Urban Development and Heritage through Pre-Construction Archaeology.” Antiquity (2025): 1–10. Web. Griffith University. “Rare stone tool cache tells story of trade and ingenuity.” 12/2/2025. https://news.griffith.edu.au/2025/12/02/rare-stone-tool-cache-tells-story-of-trade-and-ingenuity/ Han, Yu et al. “The late arrival of domestic cats in China via the Silk Road after 3,500 years of human-leopard cat commensalism.” Cell Genomics, Volume 0, Issue 0, 101099. https://www.cell.com/cell-genomics/fulltext/S2666-979X(25)00355-6 Hashemi, Sara. “A Volcanic Eruption in 1345 May Have Triggered a Chain of Events That Brought the Black Death to Europe.” Smithsonian. 12/8/2025. https://www.smithsonianmag.com/smart-news/a-volcanic-eruption-in-1345-may-have-triggered-a-chain-of-events-taht-brought-the-black-death-to-europe-180987803/ Hjortkjær, Simon Thinggaard. “Mysterious signs on Teotihuacan murals may reveal an early form of Uto-Aztecan language.” PhysOrg. 10/6/2025. https://phys.org/news/2025-10-mysterious-teotihuacan-murals-reveal-early.html Institut Pasteur. “Study suggests two unsuspected pathogens struck Napoleon's army during the retreat from Russia in 1812.” Via EurekAlert. 10/24/2025. https://www.eurekalert.org/news-releases/1102613 Jones, Sam. “Shells found in Spain could be among oldest known musical instruments.” The Guardian. 12/2/2025. https://www.theguardian.com/science/2025/dec/02/neolithic-conch-like-shell-spain-catalonia-discovery-musical-instruments Kasal, Krystal. “Pahon Cave provides a look into 5,000 years of surprisingly stable Stone Age tool use.” Phys.org. 12/16/2025. https://phys.org/news/2025-12-pahon-cave-years-stable-stone.html Kristiansen, Nina. “Eight pages bound in furry seal skin may be Norway's oldest book.” Science Norway. 11/3/2025. https://www.sciencenorway.no/cultural-history-culture-history/eight-pages-bound-in-furry-seal-skin-may-be-norways-oldest-book/2571496 Kuta, Sarah. “109-Year-Old Messages in a Bottle Written by Soldiers Heading to Fight in World War I Discovered on Australian Beach.” Smithsonian. 11/6/2025. https://www.smithsonianmag.com/smart-news/109-year-old-messages-in-a-bottle-written-by-soldiers-heading-to-fight-in-world-war-i-discovered-on-australian-beach-180987649/ Kuta, Sarah. “A Storm Battered Western Alaska, Scattering Thousands of Indigenous Artifacts Across the Sand.” Smithsonian. 10/31/2025. https://www.smithsonianmag.com/smart-news/a-storm-battered-western-alaska-scattering-thousands-of-indigenous-artifacts-across-the-sand-180987606/ Kuta, Sarah. “Archaeologists Unearth More Than 100 Projectiles From an Iconic Battlefield in Scotland.” Smithsonian. 11/5/2025. https://www.smithsonianmag.com/smart-news/archaeologists-unearth-more-than-100-projectiles-from-an-iconic-battlefield-in-scotland-180987641/ Kuta, Sarah. “Hundreds of Mysterious Victorian-Era Shoes Are Washing Up on a Beach in Wales. Nobody Knows Where They Came From.” Smithsonian. 1/5/2026. https://www.smithsonianmag.com/smart-news/hundreds-of-mysterious-victorian-era-shoes-are-washing-up-on-a-beach-in-wales-nobody-knows-where-they-came-from-180987943/ Lawson-Tancred, Jo. “Golden ‘Tudor Heart’ Necklace Sheds New Light on Henry VIII’s First Marriage.” Artnet. 10/14/2025. https://news.artnet.com/art-world/tudor-heart-pendant-british-museum-fundraiser-2699544 Lawson-Tancred, Jo. “Long-Overlooked Black Veteran Identified in Rare 19th-Century Portrait.” ArtNet. 10/27/2025. https://news.artnet.com/art-world/black-veteran-thomas-phillips-portrait-identified-2704721 Lipo CP, Hunt TL, Pakarati G, Pingel T, Simmons N, Heard K, et al. (2025) Megalithic statue (moai) production on Rapa Nui (Easter Island, Chile). PLoS One 20(11): e0336251. https://doi.org/10.1371/journal.pone.0336251 Lipo, Carl P. and Terry L. Hunt. “The walking moai hypothesis: Archaeological evidence, experimental validation, and response to critics.” Journal of Archaeological Science. Volume 183, November 2025, 106383. https://www.sciencedirect.com/science/article/abs/pii/S0305440325002328 Lock, Lisa. “Pre-construction archaeology reveals Benin City's historic urban development and heritage.” 10/29/2025. https://phys.org/news/2025-10-pre-archaeology-reveals-benin-city.html#google_vignette Lock, Lisa. “Pre-construction archaeology reveals Benin City's historic urban development and heritage.” Antiquity. Via PhysOrg. 10/29/2025. https://phys.org/news/2025-10-pre-archaeology-reveals-benin-city.html#google_vignette Lynley A. Wallis et al, An exceptional assemblage of archaeological plant fibres from Windmill Way, southeast Cape York Peninsula, Australian Archaeology (2025). DOI: 10.1080/03122417.2025.2574127 Lyon, Devyn. “Oaklawn Cemetery excavation brings investigators closer to identifying Tulsa Race Massacre victims.” Fox 23. 11/6/2025. https://www.fox23.com/news/oaklawn-cemetery-excavation-brings-investigators-closer-to-identifying-tulsa-race-massacre-victims/article_67c3a6b7-2acc-44cb-93ce-3d3d0c288eca.html Marquard, Bryan. “Bob Shumway, last known survivor of the deadly Cocoanut Grove nightclub fire, dies at 101.” 11/12/2025. https://www.bostonglobe.com/2025/11/12/metro/bob-shumway-101-dies-was-last-known-cocoanut-grove-fire-survivor/?event=event12 Marta Osypińska et al, A centurion's monkey? Companion animals for the social elite in an Egyptian port on the fringes of the Roman Empire in the 1st and 2nd c. CE, Journal of Roman Archaeology (2025). DOI: 10.1017/s1047759425100445 Merrington, Andrew. “Extensive dog diversity millennia before modern breeding practices.” University of Exeter. 11/13/2025. https://news.exeter.ac.uk/faculty-of-humanities-arts-and-social-sciences/archaeology-and-history/extensive-dog-diversity-millennia-before-modern-breeding-practices/ Morris, Steven. “Linguists start compiling first ever complete dictionary of ancient Celtic.” The Guardian. 12/8/2025. https://www.theguardian.com/science/2025/dec/08/linguists-start-compiling-first-ever-complete-dictionary-of-ancient-celtic Museum of Fine Arts, Boston. “Museum of Fine Arts, Boston, Resolves Ownership of Works by Enslaved Artist David Drake.” 10/29/2025. https://www.mfa.org/press-release/david-drake-ownership-resolution “Niagara has a 107-year-old shipwreck lodged above the Falls and it just moved.” https://www.narcity.com/niagara-falls-shipwreck-iron-scow-moved-closer-to-the-falls Newcomb, Tim. “A 76-Year-Old Man Went On a Hike—and Stumbled Upon a 1,500-Year Old Trap.” Popular Mechanics. 11/21/2025. https://www.popularmechanics.com/science/archaeology/a69441460/reindeer-trap/ Nordin, Gunilla. “Ancient wolves on remote Baltic Sea island reveal link to prehistoric humans.” Stockholm University. Via EurekAlert. 11/24/2025. https://www.eurekalert.org/news-releases/1106807 Oster, Sandee. “DNA confirms modern Bo people are descendants of ancient Hanging Coffin culture.” Phys.org. 12/6/2025. https://phys.org/news/2025-12-dna-modern-bo-people-descendants.html Oster, Sandee. “Rare disease possibly identified in 12th century child's skeletal remains.” PhysOrg. 10/10/2025. https://phys.org/news/2025-10-rare-disease-possibly-12th-century.html Osuh, Chris and Geneva Abdul. “Lost grave of daughter of Black abolitionist Olaudah Equiano found by A-level student.” The Guardian. 11/1/2025. https://www.theguardian.com/uk-news/2025/nov/01/lost-grave-daughter-black-abolitionist-olaudah-equiano-found-by-a-level-student Silvia Albizuri et al, The oldest mule in the western Mediterranean. The case of the Early Iron Age in Hort d'en Grimau (Penedès, Barcelona, Spain), Journal of Archaeological Science: Reports (2026). DOI: 10.1016/j.jasrep.2025.105506 Skok, Phoebe. “Ancient shipwrecks rewrite the story of Iron Age trade.” PhysOrg. 10/14/2025. https://phys.org/news/2025-10-ancient-shipwrecks-rewrite-story-iron.html The History Blog. “600-year-old Joseon ship recovered from seabed.” 11/15/2025. https://www.thehistoryblog.com/archives/74652 The History Blog. “Ancient pleasure barge found off Alexandria coast.” 12/9/2025. https://www.thehistoryblog.com/archives/74860 The History Blog. “Charred Byzantine bread loves stamped with Christian imagery found in Turkey.” 10/13/2025. https://www.thehistoryblog.com/archives/74352 The History Blog. “Early medieval silver treasure found in Stockholm.” 10/12/2025. https://www.thehistoryblog.com/archives/74343 The History Blog. “Roman amphora with sardines found in Switzerland.” 12/15/2025. https://www.thehistoryblog.com/archives/74904 The Straits Times. “Wreck of ancient Malay vessel discovered on Pulau Melaka.” 10/31/2025. https://www.straitstimes.com/asia/se-asia/wreck-of-ancient-malay-vessel-discovered-on-pulau-melaka Thompson, Sarah. “The forgotten daughter: Eliza Monroe Hay’s story revealed in her last letters.” W&M News. 9/30/2025. https://news.wm.edu/2025/09/30/the-forgotten-daughter-eliza-monroes-story-revealed-in-her-last-letters/ Tuhkuri, Jukka. “Why Did Endurance Sink?” Polar Record 61 (2025): e23. Web. https://www.cambridge.org/core/journals/polar-record/article/why-did-endurance-sink/6CC2C2D56087035A94DEB50930B81980 Universitat de Valencia. “The victims of the Pompeii eruption wore heavy wool cloaks and tunics, suggesting different environmental conditions in summer.” 12/3/2025. https://www.uv.es/uvweb/uv-news/en/news/victims-pompeii-eruption-wore-heavy-wool-cloaks-tunics-suggesting-different-environmental-conditions-summer-1285973304159/Novetat.html?id=1286464337848&plantilla=UV_Noticies/Page/TPGDetaillNews University of Glasgow. “Archaeologists recover hundreds of Jacobite projectiles in unexplored area of Culloden.” 10/30/2025. https://www.gla.ac.uk/news/headline_1222736_en.html University of Vienna. “Neanderthal DNA reveals ancient long-distance migrations.” 10/29/2025. https://www.univie.ac.at/en/news/detail/neanderthal-dna-reveals-ancient-long-distance-migrations Zhou, H., Tao, L., Zhao, Y. et al. Exploration of hanging coffin customs and the bo people in China through comparative genomics. Nat Commun 16, 10230 (2025). https://doi.org/10.1038/s41467-025-65264-3 Zinin, Andrew. “Ancient humans mastered fire-making 400,000 years ago, study shows.” Phys.org. 10/10/2025. https://phys.org/news/2025-12-ancient-humans-mastered-years.html See omnystudio.com/listener for privacy information.
Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-467 Overview: Join us as we discuss recent changes to newborn hepatitis B vaccination recommendations and review the risks, benefits, and rationale for immunizing this patient population. Come away with confidence to navigate new guidance, thoughtfully address parental concerns, and provide evidence-based care that promotes both infant and public health. Episode resource links: N Engl J Med 2019;380:2041-2050 DOI: 10.1056/NEJMra181047 Clin Infect Dis. 2021 Nov 2;73(9):e3317-e3323. doi: 10.1093/cid/ciaa898. Guest: Robert A. Baldor MD, FAAFP Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com
Brain Mechanisms of Change in Addiction Treatment: Models, Methods, and Emerging FindingsIn this episode, Dr. Jud explores groundbreaking insights into the brain mechanisms underlying addiction treatment. Drawing on models, methods, and findings presented at the 2015 Science of Change meeting, this research bridges neuroscience and psychotherapy to identify brain processes driving behavior change. Topics include the role of neuroimaging in understanding addiction treatments like CBT, mindfulness, and motivational interviewing, as well as how these insights pave the way for personalized, neuroscience-informed interventions.Reference: Chung, T., Noronha, A., Carroll, K. M., Potenza, M. N., Hutchison, K., Calhoun, V. D., ... & Brewer, J. A. (2016). Brain Mechanisms of Change in Addiction Treatment: Models, Methods, and Emerging Findings. Current Addiction Reports, 3(4), 332-342. DOI: 10.1007/s40429-016-0113-zLet's connect on Instagram
This week we review a recent large scale PHIS database study on pericardial effusion following congenital heart surgery. Which operations other than ASD are most highly associated with the development of an effusion? What might be some approaches both surgically and medically to reduce the chances of these developing or requiring intervention? What are the implications of a pericardial effusion after surgery? How many require readmission for this complication? Dr. Mario O'Connor, who is a congenital heart surgical research fellow at UT Austin, shares his insights into his recent publication. DOI: 10.1177/21501351251322876
AJP-Heart and Circulatory Physiology has been championing women's health research for many years, and in 2021 launched a special call for papers, which later became a standing collection in the journal, that has amassed over 100 peer reviewed publications focused on women's cardiovascular health. In 2024 the American Physiological Society launched the Women's Health Research Initiative aimed at addressing critical scientific gaps underlying health conditions that uniquely impact women. In this episode, Dr. Jason Carter (Baylor College) interviews authors Jenna Stone (McMaster University), Dr. Maureen McDonald (McMaster University), and Dr. Kerrie Moreau (University of Colorado Anschutz Medical Campus) about their recent Review article published as part of the Women's Health Research Initiative. Stone et al. discuss how traditional cardiovascular disease risk factors have been historically misidentified in females, the importance of certain metrics such as arterial stiffness and vascular endothelial function, and how early risk indicators are impacted during premenopausal period, pregnancy, and menopause. Ready to learn more? Listen now. Jenna C. Stone, Margie H. Davenport, Kerrie L. Moreau, Kyra E. Pyke, Megan M. Wenner, Jennifer S. Williams, and Maureen J. MacDonald Endocrine enigmas: vascular health in females throughout the lifespan Am J Physiol Heart Circ Physiol, published November 11, 2025. DOI: 10.1152/ajpheart.00412.2025
Uterine rupture or dehiscence associated with TOLAC results in the most significant increase in the likelihood of additional maternal and neonatal morbidity. It should be noted that the terms “uterine rupture” and “uterine dehiscence” are not consistently distinguished from each other in the literature and often are used interchangeably. Furthermore, the reported incidence of uterine rupture varies in part because some studies have grouped true, catastrophic uterine rupture together with asymptomatic scar dehiscence. In January 2026, a new meta-analysis examines the relationship between oxytocin use with TOLAC and uterine rupture. In this episode, we will summarize the key findings in that study and review the data on the use of internal monitors during TOLAC. Do internal monitors (FSE, IUPC) offer a safer TOLAC compared with external monitors? Listen in for details.1. Nicolì, Pierpaolo et al.Oxytocin dosing during trial of labor after cesarean to minimize the risk of uterine rupture: a systematic review and meta-analysisAmerican Journal of Obstetrics & Gynecology MFM, Volume 8, Issue 1, 1018462. Practice Bulletin No. 184: Vaginal Birth After Cesarean Delivery. Obstetrics & Gynecology 130(5):p e217-e233, November 2017. | DOI: 10.1097/AOG.00000000000023983. ACOG Clinical Practice Guideline No. 10:Intrapartum Fetal Heart Rate Monitoring: Interpretation and Management. Obstetrics & Gynecology 146(4):p 583-599, October 2025. | DOI: 10.1097/AOG.00000000000060494. Bruno AM, Allshouse AA, Metz TD. Maximum Oxytocin Dose and Uterine Rupture During Trial of Labor After Cesarean. Obstet Gynecol. 2025 Dec 1;146(6):843-850. doi: 10.1097/AOG.0000000000006106. Epub 2025 Oct 30. PMID: 41325062.
BUFFALO, NY – January 8, 2026 – A new #review was #published in Oncotarget (Volume 17) on January 3, 2026, titled “COVID vaccination and post-infection cancer signals: Evaluating patterns and potential biological mechanisms.” Led by Charlotte Kuperwasser from Tufts University School of Medicine and Oncotarget Editor-in-Chief Wafik S. El-Deiry from The Warren Alpert Medical School of Brown University, the review examines published reports describing cancers that appeared after COVID-19 vaccination or SARS-CoV-2 infection. The authors analyze patterns across case reports, small patient series, and large population studies, and explain why these observations are relevant for cancer research and long-term public health monitoring. Cancer remains a major global health concern, and understanding factors that may influence its behavior is important. The review covers reports published between January 2020 and October 2025 that describe cancer diagnoses, recurrence, or unusually rapid disease progression following vaccination or infection. In total, 69 publications were reviewed. Sixty-six article reports, representing more than 300 patients across multiple countries and cancer types; 2 retrospective investigations; and one longitudinal study spanning the pre-pandemic through post-pandemic periods. The review explores how immune responses triggered by infection or vaccination could, in some individuals, influence existing cancer cells or previously dormant disease. Many article reports involved blood cancers such as lymphomas and leukemias and solid tumors, including breast, lung, pancreatic, brain, and skin cancers. Some cases described rapid disease progression or cancers appearing near vaccine injection sites or nearby lymph nodes. These observations are described as hypothesis-generating rather than evidence of risk. In addition to individual case reports, the review examines findings from large population studies in South Korea, Italy, and the United States military. These studies assessed cancer trends over time in vaccinated populations and reported modest associations for certain cancer types. The authors note that these findings are limited by short follow-up periods and potential reporting and detection biases, emphasizing the need for longer-term data. The authors also discuss possible biological explanations for the reported patterns, including temporary immune changes, inflammation, or altered immune surveillance that could affect tumor behavior in people with undetected or controlled cancer. They place these observations within the broader context of how viral infections can interact with cancer biology. “Establishing causality between SARS-CoV-2 infection, COVID-19 vaccination, and cancer requires a level of evidence far beyond temporal association.” Overall, the review identifies significant gaps in current knowledge about possible associations between COVID-19 vaccination and cancer, including limited long-term cancer surveillance, lack of molecular data, and an incomplete understanding of individual susceptibility. The authors emphasize the need for carefully designed studies that integrate clinical, epidemiologic, and biological evidence. Finally, they conclude that examining these reported patterns is important for advancing cancer research and supporting informed public health discussions. DOI - https://doi.org/10.18632/oncotarget.28824 Correspondence to - Charlotte Kuperwasser - charlotte.kuperwasser@tufts.edu, and Wafik S. El-Deiry - wafik@brown.edu Abstract video - https://www.youtube.com/watch?v=5_-AaojOoR8 To learn more about Oncotarget, please visit https://www.oncotarget.com. MEDIA@IMPACTJOURNALS.COM
Rachel Sachs is a professor of law at Washington University in St. Louis. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. S.B. Dusetzina and R.E. Sachs. Insurance Coverage and Pricing of Weight-Loss Drugs in the United States. N Engl J Med 2026;394:105-107. S. Gondi, A.S. Kesselheim, and B.N. Rome. Generic Liraglutide — Overlooked but Not Forgotten. N Engl J Med. DOI: 10.1056/NEJMp2515668.
Send us a textDescription: An immersive reading of With Child by Genevieve Taggard with reflection on pregnancy, maternal mortality, pace, and isolation. Website:https://anauscultation.wordpress.comWork:With Childby Genevieve Taggard Now I am slow and placid, fond of sun,Like a sleek beast, or a worn one:No slim and languid girl—not gladWith the windy trip I once had,But velvet-footed, musing of my own,Torpid, mellow, stupid as a stone.You cleft me with your beauty's pulse, and nowYour pulse has taken body. Care not howThe old grace goes, how heavy I am grown,Big with this loneliness, how you alonePonder our love. Touch my feet and feelHow earth tingles, teeming at my heel!Earth's urge, not mine,—my little death, not hers;And the pure beauty yearns and stirs.It does not heed our ecstacies, it turnsWith secrets of its own, its own concerns,Toward a windy world of its own, toward starkAnd solitary places. In the dark,Defiant even now, it tugs and moansTo be untangled from these mother's bones.References:Goldenberg RL, McClure EM. Maternal mortality. Am J Obstet Gynecol. 2011 Oct;205(4):293-5. doi: 10.1016/j.ajog.2011.07.045. Epub 2011 Aug 4. PMID: 22083050; PMCID: PMC3893928.https://www.who.int/news-room/fact-sheets/detail/maternal-mortality Hoyert DL. Maternal mortality rates in the United States, 2023. NCHS Health E-Stats. 2025. DOI: https://dx.doi.org/10.15620/cdc/174577.Qaseem A, Wilt TJ, McLean RM, Forciea MA; Clinical Guidelines Committee of the American College of Physicians; Denberg TD, Barry MJ, Boyd C, Chow RD, Fitterman N, Harris RP, Humphrey LL, Vijan S. Noninvasive Treatments for Acute, Subacute, and Chronic Low Back Pain: A Clinical Practice Guideline From the American College of Physicians. Ann Intern Med. 2017 Apr 4;166(7):514-530. doi: 10.7326/M16-2367. Epub 2017 Feb 14. PMID: 28192789.Moyer CA, Rounds J, Hannum JW. A meta-analysis of massage therapy research. Psychol Bull. 2004 Jan;130(1):3-18. doi: 10.1037/0033-2909.130.1.3. PMID: 14717648.
Bettia Celestin, MD, and Francois Haddad, MD, join CHEST® Journal Podcast Moderator Matt Siuba, DO, MS, to discuss their research into the reliability of a fully automated deep learning workflow in echocardiography when assessing pulmonary hypertension. DOI: 10.1016/j.chest.2025.06.052 Disclaimer: The purpose of this activity is to expand the reach of CHEST content through awareness, critique, and discussion. All articles have undergone peer review for methodologic rigor and audience relevance. Any views asserted are those of the speakers and are not endorsed by CHEST. Listeners should be aware that speakers' opinions may vary and are advised to read the full corresponding journal article(s) for complete context. This content should not be used as a basis for medical advice or treatment, nor should it substitute the judgment used by clinicians in the practice of evidence-based medicine.
Mindfulness-Based Treatments for Co-Occurring Depression and Substance Use Disorders: What Can We Learn from the Brain?In this episode, Dr. Jud discusses the intersection of mindfulness, neuroscience, and treatment for individuals struggling with co-occurring depression and substance use disorders (SUDs). This seminal paper explores the shared neurobiological mechanisms underpinning these conditions and how mindfulness training (MT) addresses them. Discover the evidence behind mindfulness as a dual-diagnosis treatment, its impact on stress and rumination, and the potential for broader applications in mental health.Reference: Brewer, J. A., Bowen, S., Smith, J. T., Marlatt, G. A., & Potenza, M. N. (2010). Mindfulness-based treatments for co-occurring depression and substance use disorders: What can we learn from the brain? Addiction, 105(10), 1698–1706. DOI: 10.1111/j.1360-0443.2009.02890.xLet's connect on Instagram
This week we review a recent report on LV strain following the Ross operation. Can this sort of functional analysis help predict remodeling after aortic valve replacement? How can the type of Ross potentially affect heart function after the operation? Why might some parameters of LV strain improve but others not following surgery? Can preoperative strain measurements predict perioperative course? How does the addition of a Konno to a Ross change the outcomes of function? We speak with Chief of Cardiovascular Surgery at Primary Children's Hospital in Utah, Dr. S. Adil Husain and 3rd year integrated cardiac surgical resident Michal Schaffer of the University of Utah about these and other topics related to LV function following the Ross operation in children. · DOI: 10.1007/s00246-025-04124-9
What's the episode about? In this episode, hear Joshua Hurtardo Hurtardo on postmortal futures, future studies, de-growth, immortality imaginaries, future collective death, Westworld, and promoting your work in 2026 Who is Joshua?Joshua Hurtado Hurtado is a Mexican interdisciplinary researcher, currently finalising his PhD research at the University of Helsinki, Finland. He studied International Relations for his Bachelor's degree at the Tecnológico de Monterrey university,in Mexico. He obtained his first Master's degree in International Relations as well, specialising in Ideology and Discourse analysis, from the University of Essex, in the United Kingdom. He did a second Master's degree at the University of Turku, in Finland, this time in Futures Studies. After that, he began hisPhD research at the University of Helsinki, Finland, in Interdisciplinary Environmental Sciences. He uses his expertise in several disciplines and fields of study to conduct theoretical and empirical research on the topics of death and immortality, as well as on the topics of degrowth and sustainability more generally. Scholars in the DeathStudies field will find his articles ‘Towards a postmortalsociety of virtualised ancestors? The Virtual Deceased Person and the preservation of the social bond', ‘Envisioning postmortalfutures: six archetypes on future societal approaches to seeking immortality', and ‘Exploited in immortality: Techno-capitalism and immortality imaginaries in the twenty-firstcentury' published in the journal Mortality, his article ‘Fight, or flee, the future: Affect in contrasting responses against future collective death' published in the journal Journal of Sociology, and his book chapters ‘Westworld, Morality, and Digital Afterlives' in the edited collection Depicting the Afterlife in Contemporary Film and Media: Morality, Religion and Death byAngelique Nairn, and ‘Death, Relationality, and Resistance against Necropolitical Violence in Latin America' in the upcoming edited book Decolonising Death Studies by Panagiotis Pentaris, Stacey Pitsillides and Hajar Ghorbani. In addition to his academic trajectory, he has also worked at the Ministry of Social Development at the local level in Nuevo León, Mexico, in the roles of policy analyst and later chief of research. He has taught courses at the Undergraduate level at Tecnológico de Monterrey, in Mexico, on Business Models andEntrepreneurship (despite his insistent anti-capitalist critiques) and at the Master's level at the University of Helsinki, on Organizations and EconomicDegrowth. In his spare time, he enjoys reading, watching films and TV series, and playing with Luna, his family's dog. You can contact him via the following email addresses: joshua.hurtado.h@gmail.com (personal), and joshua.hurtado@helsinki.fi (institutional, as of January 2026). You can find him at BlueSky at @joshuahh.bsky.socialHow do I cite the episode in my research and reading lists?To cite this episode, you can use the following citation: Hurtado Hurtado, J. (2026) Interview on The Death Studies Podcast hosted by Michael-Fox, B. and Visser, R. Published 2 January 2026. Available at: www.thedeathstudiespodcast.com,DOI: 10.6084/m9.figshare.30987202What next?Check out more episodes or find out more about the hosts!Got a question? Get in touch.
BUFFALO, NY — December 30, 2025 — A new #research paper was #published in Volume 17, Issue 11 of Aging-US on November 26, 2025, titled “Epigenetic aging signatures and age prediction in human skeletal muscle.” In this study, first author Soo-Bin Yang and corresponding author Hwan Young Lee from Seoul National University College of Medicine investigated how DNA methylation patterns in skeletal muscle change with age. Their findings offer a new and highly accurate method for estimating a person's age, with potential applications in forensic science and aging research. Skeletal muscle is essential for movement, energy balance, and physical strength, functions that become more important to monitor as people age. This study improves our understanding of how muscle tissue changes over time at the molecular level. Unlike previous research, which mainly analyzed living individuals of European descent, this study used postmortem samples from an Asian population. “We analyzed DNA methylation profiles from 103 pectoralis major muscle samples from autopsies of South Korean individuals (18–85 years) using the Infinium EPIC array.” The researchers analyzed DNA from over 100 pectoralis major muscle samples taken from individuals aged 18 to 85. They identified 20 DNA methylation sites, called CpGs, that were strongly associated with age. These CpGs were found in genes involved in muscle function, stress response, metabolism, and age-related diseases. Using these markers, the team built two machine learning models to predict age: one using Next-Generation Sequencing (NGS) and another using Single Base Extension (SBE). Both models were highly accurate, with average prediction errors between 3.8 and 5.5 years. The new “epigenetic clocks” outperformed existing age-prediction models designed for other tissue types. However, when applied to cardiac and uterine muscle, these models showed much lower accuracy, reinforcing the need for tissue-specific approaches in molecular age estimation. Beyond predicting age, the study also provides insight into how DNA methylation may affect muscle aging. Several of the identified CpGs were located in regions that regulate gene expression, being associated with a reduction of it in older muscle samples. Some of the affected genes are associated with sarcopenia, an age-related loss of muscle mass and strength. Overall, this study introduces two reliable and cost-effective methods to estimate age from skeletal muscle, even when the DNA is partially degraded, making it especially useful in forensic settings. It also offers a path forward for developing future therapies that may slow age-related muscle decline and highlights how skeletal muscle aging can differ depending on population, tissue type, and anatomical location. DOI - https://doi.org/10.18632/aging.206341 Corresponding author - Hwan Young Lee - hylee192@snu.ac.kr Abstract video - https://www.youtube.com/watch?v=1i6Ua0cceMU Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206341 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, skeletal muscle, age, DNA methylation, next generation sequencing, single base extension To learn more about the journal, please visit https://www.Aging-US.com and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
HIV Patients' Perceptions of a Potential Multi-Component Mindfulness-Based Smoking Cessation Smartphone Application InterventionIn this episode, Dr. Jud explores a pivotal study on adapting a mindfulness-based smoking cessation app for people living with HIV (PLWH). This research highlights how a multi-component intervention—combining mindfulness training, contingency management, and adherence tracking for antiretroviral therapy—addresses the unique challenges faced by PLWH smokers. Discover the app's potential to reduce smoking-related health disparities, its innovative features, and participant insights on feasibility, acceptability, and improvement opportunities.Reference: Asfar, T., Alcaide, M. L., Jones, D. L., McClure, L. A., Brewer, J., Lee, D. J., & Carrico, A. (2022). HIV patients' perceptions of a potential multi-component mindfulness-based smoking cessation smartphone application intervention. PLOS ONE, 17(8), e0271946. DOI: 10.1371/journal.pone.0271946.Let's connect on Instagram
Common knowledge suggests that albino animals are rare in the wild because they stick out like a sore thumb and get eaten by predators, but studies supporting this are relatively scarce. Now, researchers from Australia have discovered that the drawbacks of albinism are not limited to their obvious appearance. Even better, they used our old friends cane toads to prove it. Become a Patreon: https://www.patreon.com/herphighlights Merch: https://www.redbubble.com/people/herphighlights/shop Full reference list available here: http://www.herphighlights.podbean.com Main Paper References: Funk AT, Martin J, Clark M, Païta A, Jolly CJ, Shine R. 2025. Knocking out genes to reveal drivers of natural selection on phenotypic traits: a study of the fitness consequences of albinism. Proceedings of the Royal Society B: Biological Sciences 292:20251458. DOI: 10.1098/rspb.2025.1458. Other Mentioned Papers/Studies: Clark MB, Funk AT, Paporakis A, Brown GP, Beach SJ, Tay A, Deering S, Cooper C, Tizard M, Jolly CJ, Ward-Fear G, Waddle AW, Shine R, Maselko M. 2025. Efficient CRISPR-Cas9-Mediated Genome Editing of the Cane Toad ( Rhinella marina ). The CRISPR Journal 8:321–332. DOI: 10.1177/25731599251382427. Stephenson BP, Velani Z, Ihász N. 2022. The effect of albinism on avian predator attack rates in eastern garter snakes. Zoology 150:125987. DOI: 10.1016/j.zool.2021.125987. Other Links/Mentions: Motorbike frog call from: https://www.inaturalist.org/taxa/517096-Ranoidea-moorei Editing and Music: Intro/outro – Treehouse by Ed Nelson Species Bi-week theme – Michael Timothy Other Music – The Passion HiFi, https://www.thepassionhifi.com
Deze week hoor je in NRC Vandaag onze serie Wilde eeuwen, het begin. Een van de verhalende series die we dit jaar maakten: perfect voor tijdens de dagen rond Kerst.Het is 40.000 jaar geleden. De jonge Doi staat oog in oog met zijn verre familie, een groep dansende neanderthalers. Zullen ze hem accepteren? Heeft u vragen, suggesties of ideeën over onze journalistiek? Mail dan naar onze redactie via podcast@nrc.nl.Voor deze aflevering is onder meer gebruikt gemaakt van deze literatuur: Francesca Romagnoli e.a. (eds) ‘Updating Neanderthals. Understanding Behavioural Complexity in the Late Middle Palaeolithic', Academic Press 2022 Mateja Hajdinjak e.a ‘Initial Upper Palaeolithic humans in Europe had recent Neanderthal ancestry' in Nature 8 april 2021. Rebecca Wragg Sykes. ‘Kindred. Neanderthal Life, Love, Death and Art', Bloomsbury 2021 Rudolf Botha. ‘Neanderthal Language. Demystifying the Linguistic Powers of our Extinct Cousins', Cambridge University Press 2020 Katerina Harvati. ‘Paleoanthropology of the Balkans and Anatolia. Human Evolution and its Context', Springer Press 2016 Qiaomei Fu e.a. ‘An early modern human from Romania with a recent Neanderthal ancestor' in Nature, 13 augustus 2015.Wil Roebroeks en Paola Villa ‘Neandertal Demise: An Archaeological Analysis of the Modern Human Superiority Complex' in PLOS One, 30 april 2014.João Zilhão e.a. ‘The Peştera cu Oase People. Europe's Earliest Modern Humans' in K. Boyle e.d. (eds) Rethinking the Human Revolution, McDonald Institute for Archaeological Research, 2007.Tekst en presentatie: Hendrik SpieringRedactie en regie: Mirjam van ZuidamMuziek, montage en mixage: Rufus van BaardwijkBeeld: Jeen BertingVormgeving: Yannick MortierZie het privacybeleid op https://art19.com/privacy en de privacyverklaring van Californië op https://art19.com/privacy#do-not-sell-my-info.
On this, our 306th Evolutionary Lens livestream, we discuss men and women, relationships and strategies. What is actually true of young women right now? Is the manosphere onto some uncomfortable and deep truths, or do they suffer from sampling and confirmation bias? What role is porn playing? Social media? Is the nonsense that emerged from #MeToo, with regard to blaming all men, seeing an analog now in the blaming of women? However: men and women are different. Women are more likely to think they have a “right to be right,” to embrace ideologies that privilege victims and grievances, and to be neurotic. Just as encouraging men to embrace their emotional side can enhance many men's lives, encouraging women to embrace the physical world is likely to enhance their lives. Finally: a book recommendation (Playground).*****Our sponsors:Manukora: the most delicious and nutritious honey you'll ever have. Get up to 31% off + $25 of free gifts with the Starter Kit at www.Manukora.com/DarkHorsePrima: Ancestral high-protein bars, easy and delicious, now in four great flavors. 20% off at EatPrima.com/DarkHorse.CrowdHealth: Pay for health care with crowdfunding instead of insurance. It's way better. Use code DarkHorse at JoinCrowdHealth.com to get 1st 3 months for $99/month.*****Join us on Locals! Get access to our Discord server, exclusive live streams, live chats for all streams, and early access to many podcasts: https://darkhorse.locals.comHeather's newsletter, Natural Selections (subscribe to get free weekly essays in your inbox): https://naturalselections.substack.comOur book, A Hunter-Gatherer's Guide to the 21st Century, is available everywhere books are sold, including from Amazon: https://amzn.to/3AGANGg (commission earned)Check out our store! Epic tabby, digital book burning, saddle up the dire wolves, and more: https://darkhorsestore.org*****Mentioned in this episode:BSW on male-female dynamics, and response from @MichaelPThelen: https://x.com/thedarkhorsepod/status/2002077458758279397 Thelwall 2017 (1of2). Book genre and author gender in Goodreads: Romance>paranormal-romance to autobiography>memoir. Journal of the Association for Information Science and Technology 68(5):1212–1223. DOI:10.1002/asi.23768. Playground, by Richard Powers: https://www.powells.com/book/playground-9781324123736Support the show
Roxy's Ride & Inspire RAWcast - Mountain Bike & Mindset Podcast
In today's episode, we dig into one of the most powerful (and most misunderstood) features of the human brain: your built in negativity bias. You'll learn:why your brain holds onto negative experienceswhy “reality” is filtered, not objectivehow the Reticular Activating System (RAS) decides what you noticeand how mountain biking is a surprisingly effective tool for retraining your attentionIf you've ever wondered why one bad ride, one mistake, or one negative comment sticks in your mind far longer than all the good stuff combined, this episode will finally help you make sense of it and CHANGE it! You'll learn practical, science-backed tools to start training your attention today (on the trail and in daily life) so your brain becomes better at noticing possibilities, capabilities, and micro-wins instead of dangers and mistakes to build a more supportive inner environment.We explore:Baumeister et al., “Bad Is Stronger Than Good”the fast subcortical threat pathway that triggers your amygdala before you can thinkwhy positive moments fade unless you consciously reinforce themhow attention literally rewires your neural pathway Hebbian learningand why your RAS acts like a “bouncer,” filtering your world based on what you engage with✨ Patreon Bonus: Patrons get a free downloadable cheat sheet that summarizes all tools and concepts from today's episode.Join here to get it PLUS other exclusive perks: https://www.patreon.com/c/rideandinspire This episode is not sponsored. It's made possible by the lovely humans who support my work on Patreon. If you want to help me keep creating science-based, real-talk MTB content, JOIN my Patreon, thank you.
In our latest episode, Deputy Editor Dr. Zam Kassiri (University of Alberta) interviews authors Dr. German González (Pontificia Universidad Católica Argentina), Dr. Rebecca Ritchie (Monash University), Dr. Pooneh Bagher (University of Nebraska Medical Center), and Dr. Hiroe Toba (Kyoto Pharmaceutical University) about the latest Guidelines in Cardiovascular Research article by Sveeggen et al. that helps researchers tackle the sources of variability in experimental models of diet-induced cardiometabolic syndrome. This podcast is a must-listen for any researcher using a diet-induced food model of disease. The authors discuss different food composition with details about type and source of fat and macronutrients, as well as environmental factors that can influence metabolic outcomes. These guidelines serve as a framework for researchers to optimize dietary interventions in cardiometabolic syndrome models and improve the predictive value of preclinical findings for translational applications. Listen now to hear more, including bonus multi-language summaries in both Spanish and Japanese. Timothy M. Sveeggen, Pooneh Bagher, Hiroe Toba, Merry L. Lindsey, Rebecca H. Ritchie, Verónica J. Miksztowicz, and Germán E. González Guidelines for diet-induced models of cardiometabolic syndrome Am J Physiol Heart Circ Physiol, published October 7, 2025. DOI: 10.1152/ajpheart.00359.2025
In this special edition on Adherence to Medications our host, Dr. Neil Skolnik will discuss medication adherence and the role of clinicians, pharmacies and pharmacists in helping with medication adherence. This special episode is supported by an independent educational grant from Amazon. Presented by: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health Susan Kuchera, M.D. - Clinical Assistant Professor of Family and Community Medicine at the Sidney Kimmel Medical College of Thomas Jefferson University and Program Director of the Family Medicine Residency at Jefferson Health Abington. Tess Carey, PharmD, Clinical Advisor for Amazon Pharmacy Selected references: Better Medications Adherence Lowers Cardiovascular Events, Stroke, and All-Cause Mortality Risk: A Dose-Response Meta-Analysis. Journal of Cardiovascular Development and Disease. 2021, 8, 146. Adherence to antihypertensive medications for secondary prevention of cardiovascular disease events: a dose-response meta-analysis. Public Health 196 (2021) 179e185 Medication nonadherence - definition, measurement, prevalence, and causes: reflecting on the past 20 years and looking forwards. Frontiers in Pharmacology, March 2025. DOI 10.3389/fphar.2025.1465059
New methods in antivenom technology may yield a treatment that works on most of the cobras in Africa, thanks to the blood of alpacas and some very clever scientists. Then we follow up with two new species of sleepyhead snake from Venezuala. Become a Patreon: https://www.patreon.com/herphighlights Merch: https://www.redbubble.com/people/herphighlights/shop Full reference list available here: http://www.herphighlights.podbean.com Main Paper References: Ahmadi S, Burlet NJ, Benard-Valle M, Guadarrama-Martínez A, Kerwin S, Cardoso IA, Marriott AE, Edge RJ, Crittenden E, Neri-Castro E, Fernandez-Quintero ML, Nguyen GTT, O'Brien C, Wouters Y, Kalogeropoulos K, Thumtecho S, Ebersole TW, Dahl CH, Glegg-Sørensen EU, Jansen T, Boddum K, Manousaki E, Rivera-de-Torre E, Ward AB, Morth JP, Alagón A, Mackessy SP, Ainsworth S, Menzies SK, Casewell NR, Jenkins TP, Ljungars A, Laustsen AH. 2025. Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites. Nature. DOI: 10.1038/s41586-025-09661-0. Species of the Bi-Week: Esqueda LF, Rojas-Runjaic FJM, Prudente A, Bazó S, Navarrete LF, Carmargo-Sillet E, Ortiz JC, Correa C, Guerrero P, Urra F. 2025. A first phylogenetic and taxonomic approach to sleepyhead snakes from Venezuela (Dipsadidae: Atractus), with the description of two new Andean species. Organisms Diversity & Evolution. DOI: 10.1007/s13127-025-00682-1. Other Links/Mentions: https://www.redbubble.com/people/herphighlights/shop Editing and Music: Intro/outro – Treehouse by Ed Nelson Species Bi-week theme – Michael Timothy Other Music – The Passion HiFi, https://www.thepassionhifi.com
BUFFALO, NY - December 17, 2025 – A new #research paper was #published in Oncotarget (Volume 16) on December 15, 2025, titled “Machine learning-based survival prediction in colorectal cancer combining clinical and biological features.” In this study, led by Lucas M. Vieira from the University of Brasília and the University of California San Diego, researchers used machine learning to predict survival in patients with colorectal cancer. They built a model by combining biological markers with clinical data. This approach could help improve prognosis and guide treatment strategies for one of the world's most common and deadly cancers. The team analyzed data from over 500 patients, using clinical details such as age, chemotherapy status, and cancer stage, along with molecular features like gene expression and microRNAs. Their goal was to improve how clinicians identify high-risk patients and make outcome predictions more precise. Researchers evaluated three different patient data scenarios using different machine learning techniques. The best-performing was an adaptive boosting model, which achieved 89.58% accuracy. This approach showed that integrating clinical and biological data led to significantly better predictions than using either data type alone. Among the biological markers, the gene E2F8 was consistently influential in all patient groups and is known to play a role in tumor growth. Other important markers included WDR77 and hsa-miR-495-3p, which are also associated with cancer development. Key clinical predictors included cancer stage, patient age, lymph node involvement, and whether chemotherapy was administered. “The proposed method combines biological and clinical features to predict patient survival, using as input data from patients from the United States, available in the TCGA database.” Unlike earlier models that relied on either clinical or molecular data alone, this study demonstrates the added value of combining both. Ensemble methods, which merge multiple learning algorithms, provided more stable and consistent results across all patient groups tested. These research findings could lead to new tools that help clinicians better predict how a patient's disease might progress or respond to treatment. The study also highlights the importance of collecting complete clinical information, such as lifestyle factors, which were missing from the dataset but could enhance future predictions. Overall, the study demonstrated how machine learning can support more accurate and personalized survival predictions in colorectal cancer. It also points to potential future research on markers like E2F8, which may be useful for monitoring or targeted therapy. DOI - https://doi.org/10.18632/oncotarget.28783 Correspondence to - Lucas M. Vieira - lvieira@health.ucsd.edu Abstract video - https://www.youtube.com/watch?v=cy7UL5ZUKuI Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28783 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, colorectal cancer, machine learning, feature selection, non-coding RNAs, genes To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us on social media: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM
Lucy may be the most famous Australopithecus fossil, but Selam is much better preserved. Researchers discovered this fossil in 2000 just across the river from where Lucy was found, and the recent exhibit at the Czech National Museum in Prague included this fossil as well as Lucy. In this episode, Paul and Todd review all the details from this skeleton, including a part that is completely unique in Australopithecus discoveries. What's the creationist angle on all this? You'll have to tune in to find out!Materials for this EpisodeWood, Todd Charles and Brummel, P. S. (2023) "Hominin Baraminology Reconsidered with Postcranial Characters," Proceedings of the International Conference on Creationism: Vol. 9, Article 28.DOI: 10.15385/jpicc.2023.9.1.15Available at: https://digitalcommons.cedarville.edu/icc_proceedings/vol9/iss1/28Does Lucy Prove Evolution? (Todd's Blog)https://toddcwood.blogspot.com/2025/01/does-lucy-prove-evolution.htmlPaul and Todd's Czech Anthropology Adventurehttps://toddcwood.blogspot.com/2025/10/paul-and-todds-czech-anthropology.htmleLucy - an evolutionary resource with scans of some of her boneshttps://elucy.org/National Museum of the Czech Republichttps://www.nm.cz/Episodes mentioned in this episodePlaylist of Paleoanthropology Episodeshttps://www.youtube.com/playlist?list=PLOzn-NecEi8EQEPL-CsmVZRo--osOXXFf
In this episode, Dr. Macy Bolt unpacks a recent study that utilizes a fan-favorite balance measure to better identify our patients who may have impaired cognitive function! DOI: 10.1519/JPT.0000000000000463 Want to make sure you stay up to date in all things Geriatrics in less than 3 minutes every other week? Join thousands of others in our free MMOA Digest Email list - https://institute-of-clinical-excellence.kit.com/a3837f54b7
This week we speak with noted congenital cardiologist Professor Krishna Kumar of the Amrita Institute in Cochin, India and discuss his recent work on inequities in congenital heart care in the world. Over 90% of patients with CHD do not have access to care in the globe today. What is the path forward to improve this sobering statistic? How can a World Health Assembly resolution practically help improve care in LMIC countries worldwide? Dr. Kumar shares his deep insights.This week we also briefly note the passing of the wonderful and caring pediatric cardiologist Dr. Sangeetha Viswanathan of Chennai, India who tragically died suddenly this week while attending the World Congress events in Hong Kong. Dr. Kumar's words regarding his friend, former fellow and colleague are read in remembrance of this wonderful and giving cardiologist whose loss will be deeply felt by her patients, family and friends. DOI: 10.1016/j.jacc.2025.07.070
Send us a textRewiring Dry Eyes: Nasal Spray Boosts Tears in Sjögren's In this episode, we unpack a 2025 pilot study from the University of Pennsylvania that tested varenicline nasal spray for dry eye disease in Sjögren's patients. Learn how neural stimulation through the nose improved tear production, reduced inflammation, and offered new hope for one of ophthalmology's most challenging autoimmune conditions.Source: Gupta AS et al., Clinical Ophthalmology. 2025;19:1073–1084. DOI: 10.2147/OPTH.S512364.LINK: Varenicline solution nasal spray for the treatment of dry eye disease | OPTH
Send us a textEric Vona describes how project-based learning can guide students from broad worries to focused, researchable questions that lead to local solutions. He talks about place-based writing born during remote learning, then shows how journalism practices—finding experts, crafting professional emails, conducting interviews—help students produce credible, public-facing work. Literature becomes a springboard for ethics and action. Pairing Ursula K. Le Guin's The Ones Who Walk Away from Omelas with contemporary responses opens honest talk about comfort, cost, and justice—conversations that translate directly to climate realities. Eric also spotlights The Echo, a teen literary magazine turned nonprofit, where students serve as real editors, publish global youth voices, and record audio for accessibility. It's a model of authentic learning that lasts beyond a grading period and builds the very capacities communities need now: curiosity, collaboration, and clear communication.John Eric Vona is a writer and educator living in Tampa, FL. Passionate about conservation and sustainability, he joined the Stories-To-Live-By project so that he could find ways to bring place-centered writing into his work as a high school AP Capstone Seminar and Creative Writing instructor. He is proud to be the advisor to The Echo: Teen Art & Lit Mag, which publishes the work of artists and writers from around the world aged 13-19. You can find The Echo at echolitmag.com/. Other resources mentioned in this episode:University of Oregon's Journalistic Learning Initiative can be found at https://journalisticlearning.org/.To cite this episode:Persohn, L. (Host). (2025,Nov 11). Stories-To-Live-By with John Eric Vona. (Season 6, No. 5) [Audio podcast episode]. In Classroom Caffeine Podcast series. https://www.classroomcaffeine.com/guests. DOI: 10.5240/6C5D-9DA8-6973-6DE9-90CA-1Connect with Classroom Caffeine at www.classroomcaffeine.com or on Instagram, Facebook, Twitter, and LinkedIn.
ECMO is the topic of this week's episode of Pediheart. We speak with Assistant Professor of Pediatrics and cardiac critical care specialist at Northwell Health, Dr. Ivana Capin about a recent ELSO database study she conducted to assess outcomes in single ventricle patients who were treated with ECMO prior to single ventricle palliation. What factors were associated with worse overall outcomes? Can this therapy be used to stabilize the HLHS patient with an intact atrial septum? Why have outcomes for this high risk patient group not appreciably improved in the recent decade? How can these data improve prognostic clarity when speaking with families in this difficult situation.Also joining us briefly is Associate Professor of Pediatrics at the Icahn School of Medicine at Mount Sinai, Dr. Scott Aydin to discuss his co-author and mentor, Dr. George Ofori-Amanfo as we approach the 4th anniversary of his untimely and tragic passing. DOI: 10.1017/S1047951125001386
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