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This week we speak with noted congenital cardiologist Professor Krishna Kumar of the Amrita Institute in Cochin, India and discuss his recent work on inequities in congenital heart care in the world. Over 90% of patients with CHD do not have access to care in the globe today. What is the path forward to improve this sobering statistic? How can a World Health Assembly resolution practically help improve care in LMIC countries worldwide? Dr. Kumar shares his deep insights.This week we also briefly note the passing of the wonderful and caring pediatric cardiologist Dr. Sangeetha Viswanathan of Chennai, India who tragically died suddenly this week while attending the World Congress events in Hong Kong. Dr. Kumar's words regarding his friend, former fellow and colleague are read in remembrance of this wonderful and giving cardiologist whose loss will be deeply felt by her patients, family and friends. DOI: 10.1016/j.jacc.2025.07.070
Send us a textRewiring Dry Eyes: Nasal Spray Boosts Tears in Sjögren's In this episode, we unpack a 2025 pilot study from the University of Pennsylvania that tested varenicline nasal spray for dry eye disease in Sjögren's patients. Learn how neural stimulation through the nose improved tear production, reduced inflammation, and offered new hope for one of ophthalmology's most challenging autoimmune conditions.Source: Gupta AS et al., Clinical Ophthalmology. 2025;19:1073–1084. DOI: 10.2147/OPTH.S512364.LINK: Varenicline solution nasal spray for the treatment of dry eye disease | OPTH
Send us a textEric Vona describes how project-based learning can guide students from broad worries to focused, researchable questions that lead to local solutions. He talks about place-based writing born during remote learning, then shows how journalism practices—finding experts, crafting professional emails, conducting interviews—help students produce credible, public-facing work. Literature becomes a springboard for ethics and action. Pairing Ursula K. Le Guin's The Ones Who Walk Away from Omelas with contemporary responses opens honest talk about comfort, cost, and justice—conversations that translate directly to climate realities. Eric also spotlights The Echo, a teen literary magazine turned nonprofit, where students serve as real editors, publish global youth voices, and record audio for accessibility. It's a model of authentic learning that lasts beyond a grading period and builds the very capacities communities need now: curiosity, collaboration, and clear communication.John Eric Vona is a writer and educator living in Tampa, FL. Passionate about conservation and sustainability, he joined the Stories-To-Live-By project so that he could find ways to bring place-centered writing into his work as a high school AP Capstone Seminar and Creative Writing instructor. He is proud to be the advisor to The Echo: Teen Art & Lit Mag, which publishes the work of artists and writers from around the world aged 13-19. You can find The Echo at echolitmag.com/. Other resources mentioned in this episode:University of Oregon's Journalistic Learning Initiative can be found at https://journalisticlearning.org/.To cite this episode:Persohn, L. (Host). (2025,Nov 11). Stories-To-Live-By with John Eric Vona. (Season 6, No. 5) [Audio podcast episode]. In Classroom Caffeine Podcast series. https://www.classroomcaffeine.com/guests. DOI: 10.5240/6C5D-9DA8-6973-6DE9-90CA-1Connect with Classroom Caffeine at www.classroomcaffeine.com or on Instagram, Facebook, Twitter, and LinkedIn.
Baseline Craving Strength as a Prognostic Marker of Benefit from Smartphone App-Based Mindfulness Training for Smoking CessationIn this episode, Dr. Jud explores cutting-edge research into how baseline craving strength influences the effectiveness of smartphone app-based mindfulness training for smoking cessation. Discover how mindfulness-based programs help smokers reduce their reliance on cigarettes by disrupting the association between cravings and smoking. We discuss the role of craving strength as a potential marker for personalized treatment, key findings from the study, and implications for future smoking cessation strategies.Reference: Roos, C. R., Brewer, J. A., O'Malley, S. S., & Garrison, K. A. (2019). Baseline Craving Strength as a Prognostic Marker of Benefit from Smartphone App-Based Mindfulness Training for Smoking Cessation. Mindfulness, 10, 2165–2171. DOI: 10.1007/s12671-019-01188-6.Let's connect on Instagram
ECMO is the topic of this week's episode of Pediheart. We speak with Assistant Professor of Pediatrics and cardiac critical care specialist at Northwell Health, Dr. Ivana Capin about a recent ELSO database study she conducted to assess outcomes in single ventricle patients who were treated with ECMO prior to single ventricle palliation. What factors were associated with worse overall outcomes? Can this therapy be used to stabilize the HLHS patient with an intact atrial septum? Why have outcomes for this high risk patient group not appreciably improved in the recent decade? How can these data improve prognostic clarity when speaking with families in this difficult situation.Also joining us briefly is Associate Professor of Pediatrics at the Icahn School of Medicine at Mount Sinai, Dr. Scott Aydin to discuss his co-author and mentor, Dr. George Ofori-Amanfo as we approach the 4th anniversary of his untimely and tragic passing. DOI: 10.1017/S1047951125001386
In this episode of the Epigenetics Podcast, we talked with Fides Zenk from the École polytechnique fédérale de Lausanne about her work on transgenerational inheritance in Drosophila and brain organoids for human development insights. Dr. Zenk begins by sharing her journey into the field of biology, revealing her childhood fascination with nature and the intricate details of plant development. Her transition from an interest in ecology to a deep dive into molecular biology and gene regulation lays the groundwork for understanding her current research focus. We explore how her early experiences continue to shape her scientific curiosity, particularly her passion for studying cellular changes over time during embryonic development. As the conversation progresses, Dr. Zenk paints a vivid picture of her work at EPFL, where she combines functional genomics, chromatin profiling, and molecular biology techniques. She elaborates on her initial research during her PhD with Nicola Iovino, where she investigated the transgenerational inheritance of histone modifications in Drosophila. This discussion includes fascinating insights into how histone modifications can carry information across generations and their implications in gene expression regulation during early embryonic stages. Dr. Zenk also provides a glimpse into her postdoctoral work with Barbara Treutlein, where she shifted focus to human models and quantitative analysis using brain organoids. This segment of the episode reveals her commitment to translating molecular mechanisms to human health, especially in understanding the intricacies of brain development and neurogenesis. She describes how her team mapped dynamic changes in histone modifications during critical developmental stages, integrating various data modalities to build an intricate developmental atlas. References Zenk F, Loeser E, Schiavo R, et al. Germ line-inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition. Science (New York, N.Y.). 2017 Jul;357(6347):212-216. DOI: 10.1126/science.aam5339. PMID: 28706074. Zenk F, Zhan Y, Kos P, et al. HP1 drives de novo 3D genome reorganization in early Drosophila embryos. Nature. 2021 May;593(7858):289-293. DOI: 10.1038/s41586-021-03460-z. PMID: 33854237; PMCID: PMC8116211. Zenk F, Fleck JS, Jansen SMJ, et al. Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems. Nature Neuroscience. 2024 Jul;27(7):1376-1386. DOI: 10.1038/s41593-024-01652-0. PMID: 38914828; PMCID: PMC11239525. Related Episodes The Role of Small RNAs in Transgenerational Inheritance in C. elegans (Oded Rechavi) Mapping the Epigenome: From Arabidopsis to the Human Brain (Joseph Ecker) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com
Gina M. Piscitello, MD, and Katrina E. Hauschildt, PhD, BCPA, join CHEST® Journal Podcast Moderator Gretchen Winter, MD, to discuss their research into the ways that and extent to which hospital policies influence clinician approaches to decisions to withhold or withdraw life-sustaining treatment among patients admitted to an ICU. DOI: 10.1016/j.chest.2025.06.036 Disclaimer: The purpose of this activity is to expand the reach of CHEST content through awareness, critique, and discussion. All articles have undergone peer review for methodologic rigor and audience relevance. Any views asserted are those of the speakers and are not endorsed by CHEST. Listeners should be aware that speakers' opinions may vary and are advised to read the full corresponding journal article(s) for complete context. This content should not be used as a basis for medical advice or treatment, nor should it substitute the judgment used by clinicians in the practice of evidence-based medicine.
Kristen R. Mathias, MD, MHS, joins CHEST® Journal Podcast Moderator Gretchen Winter, MD, to discuss her research into the ways patients with sarcoidosis describe their experiences with the disease, how they are impacted by uncertainty around sarcoidosis management, and the challenges they face in receiving care. DOI: 10.1016/j.chest.2025.06.025 Disclaimer: The purpose of this activity is to expand the reach of CHEST content through awareness, critique, and discussion. All articles have undergone peer review for methodologic rigor and audience relevance. Any views asserted are those of the speakers and are not endorsed by CHEST. Listeners should be aware that speakers' opinions may vary and are advised to read the full corresponding journal article(s) for complete context. This content should not be used as a basis for medical advice or treatment, nor should it substitute the judgment used by clinicians in the practice of evidence-based medicine.
Welcome to the Choosing Wisely Campaign series! This is the fifth and final episode of our 5-part series exploring the ABIM Foundation's Choosing Wisely Lists. This campaign aims to promote conversations between clinicians and patients to avoid unnecessary medical tests, treatments, and procedures. Our last case-based episode focuses on a school-aged male presenting with new-onset enuresis. After a discussion of the differential diagnosis and evidence-based evaluation strategies, we apply recommendations from multiple AAP Choosing Wisely lists to create a care plan that is safe, resource-conscious, and child-centered. Throughout this episode, we'll highlight how ethical care principles—beneficence, nonmaleficence, autonomy, and justice—guide high-value decision-making and help us avoid unnecessary imaging, laboratory studies, and interventions that add cost without improving outcomes. This familiar case in pediatrics is worthy of a rewind to relisten to a throwback episode that will reinforce your skills and emphasize the clinical diagnosis and management without added diagnostics, referrals, or medications. This case closes out our series on Choosing Wisely in Pediatrics, but the principles we've explored should continue to inform your practice every day. If you missed earlier episodes, rewind to learn more about the campaign's background and listen to cases on fever and cough, gastroenterology presentations, and more. Series Learning Objectives: Introduction to the Choosing Wisely Campaign: Understand the origins, historical precedent, and primary goals of the campaign. Case-Based Applications: Explore five common presentations in primary and acute care pediatrics, applying concepts from various Choosing Wisely lists to guide management and resource stewardship. Effective Communication: Learn strategies for engaging in tough conversations with parents and colleagues to create allies and ensure evidence-based practices are followed. Modified rMETRIQ Score: 15/15 What does this mean? Competencies: AACN Essentials: 1: 1.1 g; 1.2 f; 1.3 d, e 2: 2.1 d, e; 2.2 g; 2.4 f, g; 2.5 h, i, j, k 7: 7.2 g, h, k 9: 9.1i, j; 9.2 i, j; 9.3 i, k NONPF NP Core Competencies: 1: NP 1.1h; NP 1.2 k, m; NP 1.3 f, j, h 2: NP 2.1 j, g; NP 2.2 k, n; NP 2.4 h, i; NP 2.5 k, l, m, n, o 7: NP 7.2 m 9: NP 9.1 m, n; NP 9.2 n; NP 9.3 p References: AAP Section on Emergency Medicine & Canadian Association of Emergency Physicians. (2022). Five things physicians and patients should question. Retrieved from https://downloads.aap.org/AAP/PDF/Choosing%20Wisely/CWEmergencyMedicine.pdf AAP Section on Gastroenterology, Hepatology, and Nutrition. (2023). Five things physicians and patients should question. https://downloads.aap.org/AAP/PDF/Choosing%20Wisely/CWGastroenterology.pdf AAP Section on Urology. (2022). Five things physicians and patients should question. Retrieved from https://downloads.aap.org/AAP/PDF/Choosing%20Wisely/CWUrology.pdf Daniel, M., Szymanik-Grzelak, H., Sierdziński, J., Podsiadły, E., Kowalewska-Młot, M., & Pańczyk-Tomaszewska, M. (2023). Epidemiology and Risk Factors of UTIs in Children-A Single-Center Observation. Journal of personalized medicine, 13(1), 138. https://doi.org/10.3390/jpm13010138 McMullen, P.C., Zangaro, G., Selzer, C., Williams, H. (2026). Nurse Practitioner Claims and the National Practitioner Data Bank: Trends, Analysis, and Implications for Nurse Practitioner Education and Practice. Journal for Nurse Practitioners, 22(1), p. 105569, https://doi-org.proxy.lib.duke.edu/10.1016/j.nurpra.2025.105569 Tabbers, M. M., DiLorenzo, C., Berger, M. Y., Faure, C., Langendam, M. W., Nurko, S., Staiano, A., Vandenplas, Y., Benninga, M. A., European Society for Pediatric Gastroenterology, Hepatology, and Nutrition, & North American Society for Pediatric Gastroenterology (2014). Evaluation and treatment of functional constipation in infants and children: evidence-based recommendations from ESPGHAN and NASPGHAN. Journal of pediatric gastroenterology and nutrition, 58(2), 258–274. https://doi.org/10.1097/MPG.0000000000000266 UCSF Benioff Children's Hospitals. (n.d.). Constipation & urologic problems. https://www.ucsfbenioffchildrens.org/conditions/constipation-and-urologic-problems Vaughan, D. (2015). The Challenger Launch Decision: Risky Technology, Deviance, and Culture at NASA. University of Chicago Press. DOI: 10.7208/chicago/9780226346960.001.0001 Wilbanks, Bryan A. PhD, DNP, CRNA. Evaluation of Methods to Measure Production Pressure: A Literature Review. Journal of Nursing Care Quality 35(2):p E14-E19, April/June 2020. | DOI: 10.1097/NCQ.0000000000000411
What's the episode about? In this episode, hear Professor Douglas Davies on thedevelopment of death studies, ‘words against death', the ‘dividual', religion, ‘sacred secrets', the ‘opacity of the self' and the ‘curated everything', keeping a dream diaries since 1979, the over-optimism of posthumanism, wealth inequality, & the privilege of intellectuals as ‘people who think'.Who is Douglas? This introduction to Douglas Davies was written by DrGeorgina Robinson, who awarded Douglas with the Lifetime Achievement Award at the 2025 Death, dying and Disposal Conference in Utrecht, the Netherlands. Douglas Davies is a name known to all who work in theinterdisciplinary field of Death Studies. From early career scholars, fresh in the field, through to senior colleagues who have themselves deeply influenced the field, the stories that people tell of their experiences of Douglas are always warm and encouraging, yet unique to the individual: the time and careDouglas gives to all who encounter him is a true testament of his character. As a founding member of ASDS and editorial board member ofMortality Douglas has always offered a home to Death Studies scholars, having hosted numerous Death Studies events, including the International Conference onthe Social Context of Death, Dying, and Disposal and the inaugural International Symposium of the Death Online Research Network (DORS#1), as well as events for funerary professionals, including numerous Summer Schools of theNational Association of Funeral Directors. Alongside these external events, Douglas has also welcomedcountless students, researchers, and professional colleagues to Durham during his time as Director of Durham University's Centre for Death and Life Studies through visiting professorships, library scholarships to work in the Archivesof the Cremation Society of Great Britain, alongside conferences hosted by the Centre. What is unique about Douglas is that despite his countless works whichhave deeply influenced scholarly thinking within the field, more often than not, it is a conversation or engagement with him that sticks with Death Studies scholars: his kindness and encouraging nature are second-to-none. Nevertheless, the significant impact that his countlessworks have had – both academically and practically, with his work impacting policy changes and the funeral sector itself – must not be understated (e.g., Mors Britannica, 2015; Death, Ritual and Belief, 3 editions 1997, 2002, 2017;Natural Burial, 2012; A Brief History of Death, 2005; Theology of Death, 2008). Significantly, 2025 marks 50 years of Douglas's career in academia: how fitting that the association he was formative in establishing would award him with thehonour of Lifetime Achievement Award this year. How do I cite the episode in my research and reading lists? To cite this episode, you can use the following citation: Davies, D. (2025) Interview on The Death StudiesPodcast hosted by Michael-Fox, B. and Visser, R. Published 1 December 2025.Available at: www.thedeathstudiespodcast.com, DOI: 10.6084/m9.figshare.30752183 What next?Check out more episodes or find out more about the hosts! Gota question? Get in touch.
With Felix Lindberg, Karolinska Institute & Karolinska University Hospital, Stockholm - Sweden, Martha Kyriakou, European University of Cyprus, Nicosia - Cyprus and Maggie Simpson, University of Edinburgh, Edinburgh - UK. In this episode, Felix Lindberg, Martha Kyriakou, and Maggie Simpson discuss multidisciplinary care in heart failure, exploring why HF complexity and multimorbidity make coordinated, team-based management essential. They outline the key professional roles and how they can work together to support continuity across the HF trajectory, from diagnosis and optimisation, through decompensations, and transition to advanced therapies and palliative care. The discussion also addresses real-world gaps in implementation, and considers how the expanding roles of nurses, pharmacists, and allied professionals, alongside emerging digital tools, may shape the future of multidisciplinary HF care. Proposed reading: Examining the clinical role and educational preparation of heart failure nurses across Europe. A survey of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) and the Association of Cardiovascular Nursing and Allied Professions (ACNAP) of the ESC. Hill et al. 2025. Eur J Heart Fail. DOI: 10.1002/ejhf.3519 Multidisciplinary Care in Heart Failure Services. Sokos et al. 2023. J Card Fail. DOI: 10.1016/j.cardfail.2023.02.011 The Core Curriculum for Cardiovascular Nurses and Allied Professionals. Neubeck et al. 2023. Eur J Cardiovasc Nurs. DOI: 10.1093/eurjcn/zvad035 How to handle polypharmacy in heart failure. A clinical consensus statement of the Heart Failure Association of the ESC. Stolfo et al. 2025. Eur J Heart Fail. DOI: 10.1002/ejhf.3642 Pharmacist- and Nurse-Led Medical Optimization in Heart Failure: A Systematic Review and Meta-Analysis. Zheng et al. 2023. J Card Fail. DOI: 10.1016/j.cardfail.2023.03.01 Nurse-led diuretic titration via a point-of-care urinary sodium sensor in patients with acute decompensated heart failure (EASY-HF): A single-centre, randomized, open-label study. Meekers et al. 2024. Eur J Heart Fail. DOI: 10.1002/ejhf.3429 Heart failure disease management: a systematic review of effectiveness in heart failure with preserved ejection fraction. Kalogirou et al. 2020. ESC Heart Fail. DOI: 10.1002/ehf2.12559 What Are Effective Program Characteristics of Self-Management Interventions in Patients With Heart Failure? An Individual Patient Data Meta-analysis. Jonkman et al. 2016. J Card Fail. DOI: 10.1016/j.cardfail.2016.06.422 Comparative effectiveness of transitional care services in patients discharged from the hospital with heart failure: a systematic review and network meta-analysis. Van Spall et al. 2017. Eur J Heart Fail. DOI: 10.1002/ejhf.765 This 2025 HFA Cardio Talk podcast series is supported by Bayer AG in the form of an unrestricted financial support. The discussion has not been influenced in any way by its sponsor.
BUFFALO, NY — December 1, 2025 — A new #research paper featured on the #cover of Volume 17, Issue 11 of Aging-US was #published on October 30, 2025, titled “SAMP-Score: a morphology-based machine learning classification method for screening pro-senescence compounds in p16 positive cancer cells.” In this study led by first author Ryan Wallis along with corresponding author Cleo L. Bishop, from Queen Mary University of London, researchers developed a machine learning tool to identify compounds that induce cancer cells into senescence. The tool, called SAMP-Score, offers a new strategy for drug discovery in cancers with poor treatment options like basal-like breast cancer. Senescence is a process where damaged or aged cells stop dividing. In cancer therapy, inducing senescence is an approach to control tumor growth. However, it is difficult to detect true senescence in cancer cells that already appear aged. These cancers, often called Sen-Mark+ cancers, include basal-like breast cancer and typically lack reliable markers to confirm senescence. SAMP-Score was designed to address this problem. Instead of relying on traditional markers, the researchers built a machine learning model trained to recognize patterns based on senescent cells' shape and structure under a microscope. These visual patterns, known as senescence-associated morphological profiles (SAMPs), allowed the model to distinguish real signs of aging from other effects such as toxicity or normal variation. By analyzing thousands of cell images, the model learned to classify whether a cell had truly entered senescence. “To demonstrate the potential application of SAMP-Score in p16 positive cancer therapeutic discovery, we assessed a diversity screen of 10,000 novel chemical entities in MB-468 cells (p16 positive BLBC).” The team used SAMP-Score to screen more than 10,000 experimental compounds. One compound, QM5928, consistently triggered senescence in several cancer cell types without killing them, making it a promising candidate for further study. Importantly, it worked in cancers resistant to known drugs like palbociclib, which are often ineffective in cancers with high p16 expression like basal-like breast cancer. Further analysis revealed that QM5928 caused the p16 protein to move into the nucleus of cancer cells, a possible sign that the protein is helping stop cell division. This subtle effect was only detectable using the detailed imaging and analysis made possible by SAMP-Score, highlighting the tool's ability to distinguish true senescence from toxic responses and making it a powerful resource in cancer drug discovery. By combining machine learning with high-resolution imaging, this study introduces a new way to find and evaluate cancer therapies. SAMP-Score could accelerate efforts to develop treatments that exploit the body's natural aging processes to fight cancer, especially for patients with resistant tumors. The tool is openly available at GitHub, making it accessible for other researchers exploring senescence-based cancer therapies. DOI - https://doi.org/10.18632/aging.206333 Corresponding author - Cleo L. Bishop - c.l.bishop@qmul.ac.uk Abstract video - https://www.youtube.com/watch?v=qXI_KI3EgHE Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit https://www.Aging-US.com and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@Aging-US LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
In the last ten years, 'diagnostic stewardship' has emerged as a core principle of good clinical practice whose implementation impacts both the individual patient and public health at large. In this episode of Communicable, hosts Angela Huttner and Annie Joseph invite two experts in the field, Daniel Morgan (Maryland, USA) and Valerie Vaughn (Utah, USA), to discuss diagnostic stewardship in the context of infectious diseases, hospital medicine, and healthcare in general. Other topics covered include practical interventions for better testing practices and the role of artificial intelligence in the future of diagnostics. The episode highlights how thoughtful, intentional diagnostic practices can enhance clinician workflows and improve patient outcomes.This episode is a follow-up from Morgan's recently published commentary in CMI Communications on diagnostic testing, and the need for evaluating its clinical impact [1]. The episode was peer reviewed by Özlem Türkmen Recen of Çınarcık State Hospital, Yalova, Türkiye. ReferencesBaghdadi JD & Morgan DJ. Diagnostic tests should be assessed for clinical impact. CMI Comms 2024. DOI: 10.1016/j.cmicom.2024.105010Further readingAdvani S and Vaughn VM. Quality Improvement Interventions and Implementation Strategies for Urine Culture Stewardship in the Acute Care Setting: Advances and Challenges. Curr Infect Dis Rep 2021. DOI: 10.1007/s11908-021-00760-3 Core Elements of Hospital Antibiotic Stewardship Programs, https://www.cdc.gov/antibiotic-use/hcp/core-elements/hospital.html Core Elements of Hospital Diagnostic Excellence (DxEx), https://www.cdc.gov/patient-safety/hcp/hospital-dx-excellence/index.htmlCosgrove SE & Srinivasan A. Antibiotic Stewardship: A Decade of Progress. Infect Dis Clin North Am 2023. DOI: 10.1016/j.idc.2023.06.003 Dik JH, et al. Integrated Stewardship Model Comprising Antimicrobial, Infection Prevention, and Diagnostic Stewardship (AID Stewardship). J Clin Microbiol 2017. DOI: 10.1128/jcm.01283-17Fabre V, et al. Principles of diagnostic stewardship: A practical guide from the Society for Healthcare Epidemiology of America Diagnostic Stewardship Task Force. Infect Control Hosp Epidemiol 2023. DOI: 10.1017/ice.2023.5 Huttner A, et al. Re: ‘ESR and CRP: it's time to stop the zombie tests' by Spellberg et al. CMI 2025. DOI: 10.1016/j.cmi.2024.09.016 Morgan DJ, et al. Diagnostic Stewardship—Leveraging the Laboratory to Improve Antimicrobial Use. JAMA 2017. DOI: 10.1001/jama.2017.8531 Messacar K, et al. Implementation of rapid molecular infectious disease diagnostics: the role of diagnostic and antimicrobial stewardship. J Clin Microbiol 2017. DOI: 10.1128/jcm.02264-16Messacar K, et al. Clinical and Financial Impact of a Diagnostic Stewardship Program for Children with Suspected Central Nervous System Infection. J Pediatr. 2022. DOI: 10.1016/j.jpeds.2022.02.002 Qian ET, et al. Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized With Acute Infection: The ACORN Randomized Clinical Trial. JAMA 2023. DOI: 10.1001/jama.2023.20583 Siontis KC et al. Diagnostic tests often fail to lead to changes in patient outcomes. J Clin Epidemiol 2014. DOI: 10.1016/j.jclinepi.2013.12.008Vaughn VM, et al. Antibiotic Stewardship Strategies and Their Association With Antibiotic Overuse After Hospital Discharge. Clin Infect Dis 2022. DOI: 10.1093/cid/ciac104Vaughn VM, et al. A Statewide Quality Initiative to Reduce Unnecessary Antibiotic Treatment of Asymptomatic Bacteriuria. JAMA Intern Med 2023. DOI: 10.1001/jamainternmed.2023.2749
Vorlesungen zur Linguistik und Sprachgeschichte des Deutschen
In dieser Sitzung verlassen wir den Bereich von Syntax und Morphologie und wenden uns einem Feld zu, das in den kommenden Jahren sicher an Bedeutung gewinnen wird: der Multimodalität – mit besonderem Fokus auf Prosodie und Intonation. Wir beleuchten, wie bestimmte syntaktische Muster nicht nur durch Wortstellung, sondern auch durch ihre lautliche Realisierung Bedeutung tragen. Im Zentrum steht dabei der narrative Konnektor „und dann“ (sowie Variationen wie „und bald darauf“) und die Frage, wie diese Strukturen speziell beim Erzählen und Erklären eingesetzt werden. Zudem möchte ich zeigen, wie sich Generative KI (GenKI) nutzen lässt, um spezifische gesprochensprachliche Phänomene in Videos (z. B. aus der Sendung „Dingsda“) effizient zu identifizieren.Präsentation (*.pdf): Alexander Lasch. 2025. Konstruktionsgrammatik. Zenodo. DOI: https://doi.org/10.5281/zenodo.17370032. Videoaufzeichnungen: https://youtube.com/@AlexanderLasch. Informationen & Material zu allen Vorlesungen: https://kurzelinks.de/fl7f. Worksheet zu den Vorlesungen: https://kurzlinks.de/WorksheetVorlesungen. Intro: "Reflections" von Scott Holmes (CC BY via FMA).#Linguistik #OER #Sprache #Sprachwissenschaft #Grammatik #Konstruktionsgrammatik
In this week's episode, we discuss paediatric feeding and Avoidant / Restrictive Food Intake Disorder, or ARFID. We are joined by a multi-disciplinary panel to discuss collaborative supports. Psychologist Dr Katherine Bartlett, dietitian Rachel Tutill, and speech pathologist Val Gent discuss recent research about paediatric feeding needs including ARFID, as well as supports, and resources for clinicians and family or supporters. Resources: Winten, Copeland G., Strodl, Esben, & Ross, Lynda J. (2024) Multidisciplinary Treatment of Avoidant/Restrictive Food Intake Disorder. Psychiatric Annals, 54(2), e51-e55 DOI:10.3928/00485713-20240119-01 Gent, Valerie., Marshall, Jeanne., Weir, Kelly A., & Trembath, David. (2025) Caregiver perspectives regarding the impact of feeding difficulties on mealtime participation for primary school-aged autistic children and their families. International Journal of Speech-Language Pathology, International Journal of Speech-Language Pathology, February, 1–11. doi:10.1080/17549507.2025.2452901 Gent, Valerie., Marshall, Jeanne., Weir, Kelly A., & Trembath, David. (2024). Investigating the impact of autistic children's feeding difficulties on caregivers. Child: Care, Health and Development, 50(1), e13218. https://doi.org/10.1111/cch.13218 Feeding matters: www.feedingmatters.org It's not picky eating: www.itsnotpickyeating.org The Victorian Centre for Excellence in Eating Disorders (CEED) resources library https://ceed.org.au/resources/?_resources_search=ARFID Speech Pathology Australia acknowledge the Traditional Custodians of lands, seas and waters throughout Australia, and pay respect to Elders past and present. We recognise that the health and social and emotional wellbeing of Aboriginal and Torres Strait Islander peoples are grounded in continued connection to culture, country, language and community and acknowledge that sovereignty was never ceded. Free access to transcripts for podcast episodes are available via the SPA Learning Hub (https://learninghub.speechpathologyaustralia.org.au/), you will need to sign in or create an account. For more information, please see our Bio or for further enquiries, email speakuppodcast@speechpathologyaustralia.org.au Disclaimer: © (2025) The Speech Pathology Association of Australia Limited. All rights reserved. Important Notice, Please read: The views expressed in this presentation and reproduced in these materials are not necessarily the views of, or endorsed by, The Speech Pathology Association of Australia Limited (“the Association”). The Association makes no warranty or representation in relation to the content, currency or accuracy of any of the materials comprised in this recording. The Association expressly disclaims any and all liability (including liability for negligence) in respect of use of these materials and the information contained within them. The Association recommends you seek independent professional advice prior to making any decision involving matters outlined in this recording including in any of the materials referred to or otherwise incorporated into this recording. Except as otherwise stated, copyright and all other intellectual property rights comprised in the presentation and these materials, remain the exclusive property of the Association. Except with the Association's prior written approval you must not, in whole or part, reproduce, modify, adapt, distribute, publish or electronically communicate (including by online means) this recording or any of these materials.
This week, Stu lets us into the secret world of moss, how they're different to other plants, and how they're so hardy they can even survive on the outside of spacecraft; and Claire gets her teeth into a new, large longitudinal study that showed water fluoridation did not harm cognition or IQ. Maeng, Chang-hyun et al., Extreme environmental tolerance and space survivability of the moss, Physcomitrium patens. iScience, Volume 0, Issue 0, 113827 (2025). DOI: 10.1016/j.isci.2025.113827 John Robert Warren et al., Childhood fluoride exposure and cognition across the life course. Sci. Adv. 11, eadz0757 (2025). DOI:10.1126/sciadv.adz0757
Urban areas represent both opportunities and risks for animals, and they adapt their behaviour in many ways to cope with this fast-paced lifestyle. Now, a new study has detailed how urban wall lizards in Croatia have richer social lives than their rural counterparts. Then we chat about a listener-submitted story detailing wild lizards eating pizza. Become a Patreon: https://www.patreon.com/herphighlights Merch: https://www.redbubble.com/people/herphighlights/shop Full reference list available here: http://www.herphighlights.podbean.com Main Paper References: Maune AL, Wittenbreder T, Lisičić D, Caspers BA, Camerlenghi E, Damas-Moreira I. 2025. City lizards are more social. Biology Letters 21:20250326. DOI: 10.1098/rsbl.2025.0326. Other Mentioned Papers/Studies: Dendi, D., Segniagbeto, G. H., Meek, R., & Luiselli, L. (2023). Opportunistic foraging strategy of rainbow lizards at a seaside resort in Togo. African Journal of Ecology, 61(1), 226-227. Editing and Music: Intro/outro – Treehouse by Ed Nelson Species Bi-week theme – Michael Timothy Other Music – The Passion HiFi, https://www.thepassionhifi.com
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BUFFALO, NY — November 25, 2025 — A new #research paper was #published in Volume 17, Issue 10 of Aging-US on October 13, 2025, titled “Hospitalization with infections and risk of Dementia: a systematic review and meta-analysis.” This large-scale meta-analysis, led by first author Wei Yu Chua from the National University of Singapore and corresponding author Eng-King Tan from the National Neuroscience Institute and Duke-NUS Medical School in Singapore, shows that adults hospitalized with infections have a significantly higher risk of developing dementia. The findings are especially important as global populations grow older and hospitalizations for infections increase, highlighting a potential new approach for dementia prevention. “Out of 1900 studies that were screened initially, 16 studies comprising 4,266,276 patients were included for analysis.” The researchers analyzed data from over 4 million individuals across 16 studies, making this study the most comprehensive review to date on the association between infection-related hospital stays and long-term brain health. The results showed that being hospitalized for an infection raised the risk of all-cause dementia by 83%. Among the types of infections studied, sepsis carried the highest risk, followed by pneumonia, urinary tract infections, and skin or soft tissue infections. The risk of developing vascular dementia was notably higher than that of Alzheimer's disease. One possible explanation for the association between infections and dementia is that infections trigger systemic inflammation that may reach the brain. Inflammatory molecules can cross the blood-brain barrier, potentially leading to the buildup of damaging proteins and the death of brain cells. This process may be more severe in older adults, whose immune systems are often slower to respond and recover. The study also suggests that even a single infection-related hospitalization can speed up cognitive decline, especially in individuals already at higher risk. Importantly, the risk of dementia was greatest within the first year following an infection but remained elevated for many years afterward. In fact, studies with follow-ups longer than a decade showed even stronger associations. These results suggest the need for early cognitive monitoring after hospital discharge, particularly in older adults recovering from infections. These findings have important implications for healthcare systems, particularly those serving aging populations, and underscore the lasting impact that infections can have on the brain. This research highlights the importance of looking beyond genetics and lifestyle for prevention strategies. With over 50 million people affected by dementia worldwide and annual care costs in the U.S. exceeding $300 billion, identifying new and preventable risk factors is critical. Reducing infections, improving hospital care, and monitoring brain health after illness may offer promising ways to protect cognitive function in aging populations. DOI - https://doi.org/10.18632/aging.206329 Corresponding author - Eng-King Tan - tan.eng.king@singhealth.com.sg Abstract video - https://www.youtube.com/watch?v=uyv5VHHHIA4 Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206329 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, visit https://www.Aging-US.com and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@Aging-US LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-460 Overview: Join us as we discuss how frequently patients with stable hypertension should monitor their blood pressure at home. Hear insights from two trials to help you provide evidence-based, cost-conscious guidance—reducing unnecessary alarms while supporting better long-term management. Episode resource links: Rose, Francesa; Stevens, Richard S.a; Morton, Kate S.b; Yardley, Lucyc; McManus, Richard J.a,d. How often should self-monitoring of blood pressure be repeated? A secondary analysis of data from two randomized controlled trials. Journal of Hypertension ():10.1097/HJH.0000000000004123, August 20, 2025. | DOI: 10.1097/HJH.0000000000004123 Guest: Robert A. Baldor MD, FAAFP Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com
Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-460 Overview: Join us as we discuss how frequently patients with stable hypertension should monitor their blood pressure at home. Hear insights from two trials to help you provide evidence-based, cost-conscious guidance—reducing unnecessary alarms while supporting better long-term management. Episode resource links: Rose, Francesa; Stevens, Richard S.a; Morton, Kate S.b; Yardley, Lucyc; McManus, Richard J.a,d. How often should self-monitoring of blood pressure be repeated? A secondary analysis of data from two randomized controlled trials. Journal of Hypertension ():10.1097/HJH.0000000000004123, August 20, 2025. | DOI: 10.1097/HJH.0000000000004123 Guest: Robert A. Baldor MD, FAAFP Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com
Why is a broad approach that works with iPSC-derived cardiomyocytes so important to understanding molecular mechanisms underlying calcium homeostasis and arrhythmias? In this episode, Associate Editor Dr. Petra Kleinbongard (University of Duisburg-Essen) interviews author Dr. Katrin Streckfuss-Bömeke (University Medical Center Göttingen) and expert Dr. Melanie Paillard (Université Claude Bernard Lyon 1) about the new study by Ajmail et al. While arrhythmias in calcium transients are easy to detect by human perception, quantifying arrhythmias in a computer-readable manner is often difficult. To tackle the challenge, the authors developed an open-source program called Arrhythpy that quantifies and classifies confocal microscopy-based Fluo-4 Ca2+ transients to generate a measure of arrhythmia. What is unique about Arrhythpy is that it directly measures the shape and frequency of transients. The program includes two parts: frequency profiling using a method called wavelet transformation, and measuring transient peak shape using a method called autocorrelation function. After combining these measurements, Arrhythpy classifies each transient into one of 6 different subgroups. No specialty training is needed, and no specialized platforms are required to use Arrhythpy. The program can be used with different microscopes, cell types, and calcium dyes. What is the utility of Arrhythpy beyond the arrhythmia field? Listen now to find out. Karim Ajmail, Charlotte Brand, Thomas Borchert, Benjamin Meder, Sabine Rebs, Katrin Streckfuss-Bömeke Arrhythpy: An Automated Tool to Quantify and Classify Arrhythmias in Ca2+ Transients of iPSC-Cardiomyocytes Am J Physiol Heart Circ Physiol, published September 15, 2025. DOI: 10.1152/ajpheart.00414.2025
A Systematic Review and Meta-Analysis of Psychosocial Interventions for Persons with Comorbid Anxiety and Substance Use DisordersIn this episode, Dr. Jud dives into the comprehensive findings of a meta-analysis on psychosocial interventions for individuals facing the dual challenge of anxiety and substance use disorders. This research sheds light on the efficacy of treatments like cognitive behavioral therapy (CBT), motivational interviewing, and integrated care in addressing anxiety, alcohol consumption, and substance use. Join us as we explore the transformative potential of these interventions, the complexities of treating co-occurring conditions, and the pressing gaps in research for broader substance categories like opioids and methamphetamines.Reference: Nardi, W. R., Kelly, P., Roy, A., Becker, S., Brewer, J., & Sun, S. (2024). A systematic review and meta-analysis of psychosocial interventions for persons with comorbid anxiety and substance use disorders. Journal of Substance Use and Addiction Treatment, 165, 209442. DOI: 10.1016/j.josat.2024.209442Let's connect on Instagram
Vorlesungen zur Linguistik und Sprachgeschichte des Deutschen
In dieser Vorlesung steht das komplexe Verhältnis zwischen Framesemantik und Konstruktionsgrammatik im Mittelpunkt. Die Sitzung bietet einen Einblick in aktuelle Forschungsdebatten und zeigt auf, wie unterschiedlich Sprachwissen modelliert werden kann: Exemplarisch ist dafür das Verhältnis zwischen deduktiven und induktiven (gebrauchsbasierten) Beschreibungsmodellen. Es soll daran deutlich werden, dass wissenschaftliche Modellierung oft ein offener Prozess ist. Insofern ist diese Vorlesung ein "Werkstattbericht" für alle, die einen Blick in die linguistische Theoriebildung werfen möchten. 00:49:43 Mea culpa: In den letzten Slides habe ich live korrigiert, da diese tatsächlich Work in Progress sind und noch fehlerhaft waren. In der Präsentation zum Kurs sind diese bereits korrigiert und im Blogpost zur Vorlesung habe ich sie zur Sicherheit ebenfalls noch einmal eingestellt.Präsentation (*.pdf): Alexander Lasch. 2025. Konstruktionsgrammatik. Zenodo. DOI: https://doi.org/10.5281/zenodo.17370032. Videoaufzeichnungen: https://youtube.com/@AlexanderLasch. Informationen & Material zu allen Vorlesungen: https://kurzelinks.de/fl7f. Worksheet zu den Vorlesungen: https://kurzlinks.de/WorksheetVorlesungen. Intro: "Reflections" von Scott Holmes (CC BY via FMA).#Linguistik #OER #Sprache #Sprachwissenschaft #Grammatik #Konstruktionsgrammatik
This week we review the topic of mitral annular disjunction ("MAD") and the possible association with ventricular arrhythmia or sudden death in the connective tissue disease patient. Is there a 'cut off' distance above which patients deserve more significant arrhythmia surveillance? What is the best way to measure the MAD distance? Can patients with low MAD distances have lower degrees or even no arrhythmic surveillance? How often should this distance be measured on CMR and can an echo measurement provide similar data? Dr. Daniel Castellanos, the first author of this work and Assistant Professor of Pediatrics at Harvard Medical School shares his deep insights this week.DOI: 10.1016/j.jocmr.2025.101954
Dr Alexander Montoye is working as an Associate professor of Clinical Exercise Physiology at Alma College, Michigan, U.S. His main research area involves physical activity monitoring devices. He studies the accuracy and reliability of various physical activity monitors and also uses them as intervention tools to help individuals become more physically active. --- Advanced analytic methods (by other research groups), and a repository to make such models easier to find and use. Pfeiffer KA, Clevenger KA, Kaplan A, Van Camp CA, Strath SJ, Montoye AHK. Accessibility and use of novel methods for predicting physical activity and energy expenditure using accelerometry: A scoping review. Phys Meas. 2022; 43(9). DOI: 10.1088/1361-6579/ac89ca. Clevenger KA, Montoye AHK, Van Camp CA, Strath SJ, Pfeiffer KA. Methods for estimating physical activity and energy expenditure using raw accelerometry data or novel analytical approaches: A repository, framework, and reporting guidelines. Phys Meas. 2022; 43(9). DOI: 10.1088/1361-6579/ac89c9. _____________________ This podcast episode is sponsored by Fibion Inc. | Better Sleep, Sedentary Behaviour and Physical Activity Research with Less Hassle --- Collect, store and manage SB and PA data easily and remotely - Discover ground-breaking Fibion SENS --- SB and PA measurements, analysis, and feedback made easy. Learn more about Fibion Research --- Learn more about Fibion Sleep and Fibion Circadian Rhythm Solutions. --- Fibion Kids - Activity tracking designed for children. --- Collect self-report physical activity data easily and cost-effectively with Mimove. --- Explore our Wearables, Experience sampling method (ESM), Sleep, Heart rate variability (HRV), Sedentary Behavior and Physical Activity article collections for insights on related articles. --- Refer to our article "Physical Activity and Sedentary Behavior Measurements" for an exploration of active and sedentary lifestyle assessment methods. --- Learn about actigraphy in our guide: Exploring Actigraphy in Scientific Research: A Comprehensive Guide. --- Gain foundational ESM insights with "Introduction to Experience Sampling Method (ESM)" for a comprehensive overview. --- Explore accelerometer use in health research with our article "Measuring Physical Activity and Sedentary Behavior with Accelerometers ". --- For an introduction to the fundamental aspects of HRV, consider revisiting our Ultimate Guide to Heart Rate Variability. --- Follow the podcast on Twitter https://twitter.com/PA_Researcher Follow host Dr Olli Tikkanen on Twitter https://twitter.com/ollitikkanen Follow Fibion on Twitter https://twitter.com/fibion https://www.youtube.com/@PA_Researcher
In this episode, Tom Varghese, MD, FACS, is joined by Ziad Sifri, MD, FACS, from Rutgers New Jersey Medical School, and Matthew Linz, MD, from Rutgers Robert Wood Johnson Medical School. They discuss Drs Sifri and Linz's recent article, “Postoperative Pain Management in the US vs Low- and Middle-Income Countries by US Surgeons,” in which they found that surgeons in the US prescribe significantly more opioids after inguinal hernia repair compared with when they operate on short-term surgical trips to low- and middle-income countries, despite continued efforts to reduce opioid overprescription in the US. Disclosure Information: Drs Varghese, Linz, and Sifri have nothing to disclose. To earn 0.25 AMA PRA Category 1 Credits™ for this episode of the JACS Operative Word Podcast, click here to register for the course and complete the evaluation. Listeners can earn CME credit for this podcast for up to 2 years after the original air date. Linz, Matthew S MD1; Parvin-Nejad, Fatemeh P MD2; Srinivasan, Nivetha MD3; Vegunta, Geetasravya MD1; Eng, Ashley K BS1; Kim, Eugene BA MBS; Alexander, Imani BS1; Elgammal, Fatima MD2; Benson, Ryan MD2; Benneh, Albert Y MD4; Gyakobo, Mawuli K MD5,6; Lopez, Lorena MD7; Jalloh, Samba MD8; Sifri, Ziad C MD FACS2. Postoperative Pain Management in the US vs Low-and-Middle-Income Countries by US Surgeons. Journal of the American College of Surgeons ():10.1097/XCS.0000000000001538, July 30, 2025. | DOI: 10.1097/XCS.0000000000001538 Learn more about the Journal of the American College of Surgeons, a monthly peer-reviewed journal publishing original contributions on all aspects of surgery, including scientific articles, collective reviews, experimental investigations, and more. #JACSOperativeWord
BUFFALO, NY — November 20, 2025 — A new #research paper was #published in Volume 17, Issue 10 of Aging-US on October 10, 2025, titled “Developmental arrest rate of an embryo cohort correlates with advancing reproductive age, but not with the aneuploidy rate of the resulting blastocysts in good prognosis patients: a study of 25,974 embryos.” In this large-scale study, Andres Reig of the IVIRMA Global Research Alliance and Robert Wood Johnson Medical School, along with Emre Seli of the IVIRMA Global Research Alliance and Yale School of Medicine, investigated how female age and chromosomal abnormalities affect embryo development in patients undergoing in vitro fertilization (IVF). They found that embryo developmental arrest (EDA) becomes more common as women age. However, this arrest is not directly associated with the presence of chromosomal errors in the embryos that continue to develop. These findings could help improve fertility counseling and treatment strategies. The researchers analyzed 25,974 embryos from 1,928 IVF cycles, all from patients with a good chance of success. The study showed that the percentage of embryos that stopped developing before reaching the blastocyst stage increased with age: from 33% in women under 35 to 44% in those over 42. Despite this rise, the rate of chromosomal abnormalities, known as aneuploidy, in the embryos that did reach the blastocyst stage did not show a strong connection with the rate of arrest after adjusting for age. This distinction is important because both developmental arrest and aneuploidy reduce the number of embryos suitable for transfer. But this study suggests they are caused by different biological processes. In other words, an embryo may stop developing even if it has the correct number of chromosomes, and some embryos with chromosomal abnormalities may still grow to the blastocyst stage. “A very weak positive correlation was identified between EDA rate and the rate of aneuploidy (r: 0.07, 95% CI 0.03–0.11; R2: 0.00, p < 0.01) when evaluating all cohorts.” The authors suggest that other factors, such as the health of the egg's mitochondria or mutations in maternal-effect genes, may explain why some embryos stop developing. These insights could help researchers identify new ways to improve embryo quality, especially for older women undergoing IVF. Importantly, the study focused on embryos that developed far enough to be tested, which helped avoid technical problems that come with analyzing arrested embryos directly. This approach allowed for more reliable comparisons across age groups and embryo quality. Overall, the study highlights the importance of maternal age as a key factor in embryo development, independent of chromosomal results. It also opens new directions for research, aiming to better understand why embryos fail to develop and how this knowledge might lead to improved fertility treatments in the future. DOI - https://doi.org/10.18632/aging.206328 Corresponding author - Emre Seli - emre.seli@yale.edu Abstract video - https://www.youtube.com/watch?v=g0oS3HBNmuQ Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206328 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, ovarian aging, reproductive aging, embryonic arrest, embryonic aneuploidy, developmental arrest To learn more about the journal, please visit https://www.Aging-US.com and connect with us on social media: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@Aging-US LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
Regional anesthesia, typically with a spinal or epidural, haslong been favored for cesarean births due in part to concerns about the effects that general anesthesia (GA) may have on newborns at delivery. However, data has shown that up to 1 in 6 women may experience pain with a “topped-off”labor epidural, during the cesarean. A new publication in the journal Anesthesia is now being interpreted as implying that general anesthesia may be a valid alternative electively. Is that what this new study found? Has GA been linked to postpartum depression? What about later child neurodevelopmental delays? This is a fascinating topic…Listen in for details. 1. Langer, Sarah M.D.1; Lim, Grace M.D., M.Sc.2;Qiu, Yue M.D.3; Biaesch, Jingyuan D.O.4; Neuman, Mark D. M.D., M.Sc.5. NeonatalOutcomes with Regional versus General Anesthesia for Cesarean Delivery: AMeta-analysis of Randomized Controlled Trials. Anesthesiology():10.1097/ALN.0000000000005785, November 12, 2025. | DOI:10.1097/ALN.00000000000057852. Guglielminotti J, Monk C, Russell MT, Li G.Association of General Anesthesia for Cesarean Delivery with PostpartumDepression and Suicidality. Anesth Analg. 2025 Sep 1;141(3):618-628. doi:10.1213/ANE.0000000000007314. Epub 2024 Dec 4. PMID: 39630595; PMCID:PMC12134152.3. Chen, YC., Liang, FW., Tan, PH. et al.Association between general anesthesia for cesarean delivery and subsequentdevelopmental disorders in children: a nationwide retrospective cohort study.BMC Med 23, 119 (2025). https://doi.org/10.1186/s12916-025-03886-64. https://www.pennmedicine.org/news/new-study-challenges-fears-about-general-anesthesia-during-c-section
This episode cuts through the noise and explains why creatine is one of the most effective, well-researched supplements for women, not just for building muscle, but for thinking sharper, recovering faster, and staying steady when life is heavy. We break down the physiology, the misconceptions, and the real-world benefits so you can use creatine with clarity and confidence.I used one main paper to research all the mechanistic stuff for this episode. It is free to access and it's AMAZING:Creatine Supplementation Beyond Athletics: Benefits of Different Types of Creatine for Women, Vegans, and Clinical Populations — A Narrative ReviewGutiérrez-Hellín J., Del Coso J., Franco-Andrés A., Gamonales J.M., Espada M.C., González-García J., López-Moreno M., Varillas-Delgado D.Nutrients (2025).PMCID: PMC11723027 | DOI: 10.3390/nu17010095Then some of the other studies I mentioned can be found here: 1. Single Dose Creatine Improves Cognitive Performance and Induces Changes in Cerebral High-Energy Phosphates During Sleep DeprivationGordji-Nejad A., Matusch A., Kleedörfer S., Patel H.J., Drzezga A., Elmenhorst D., Binkofski F., Bauer A.Scientific Reports (2024).PMCID: PMC10902318 | DOI: 10.1038/s41598-024-54249-9What it's aboutA high single dose of creatine helped offset the cognitive decline and metabolic stress caused by sleep deprivation, temporarily boosting brain energy systems and mental performance.2. Creatine Promotes Endometriosis Progression by Inducing M2 Polarization of Peritoneal MacrophagesChen S.-M., Liu Y.-K., Ma X.-Q., Wei C.-Y., Li M.-Q., Zhu X.-Y.Reproduction (2024).DOI: 10.1530/REP-24-0278 | PMID: 39679878What it's aboutThis study found that creatine can shift peritoneal macrophages into an M2, pro-growth state, which may accelerate inflammation, angiogenesis, and lesion development in endometriosis.3. Effects of Long-Term Low-Dose Dietary Creatine Supplementation in Older WomenLobo D.M., Tritto A.C., da Silva L.R., de Oliveira P.B., Benatti F.B., Roschel H., Nieß B., Gualano B., Pereira R.M.R.Experimental Gerontology (2015).DOI: 10.1016/j.exger.2015.07.012 | PMID: 26192975What it's aboutA year of very low-dose creatine (1 g/day) was safe but too small a dose to produce measurable changes in bone health, lean mass, or muscle function in postmenopausal women.
אוכלים אכילה רגשית? מעטים יודעים שאכילה רגשית והתקפי האכילה יכולים לרמז על משהו הרבה יותר מסוכן – הם יכולים להיות תסמין של דיכאון. ודווקא בתקופה שבה יש עליה בדיכאון (אחרי המלחמה), זה פרק שיכול להציל חיים. בפרק הזה אני מדברת על איך על איך דיכאון משפיע על רעב, חשקים ועל חיבור לגוף (וזה יחדש לכם), וגם איך האוכל עצמו יכול דווקא לעזור מול דיכאון. זה פרק שמנקה רעשי רקע, ומסביר בצורה פשוטה למה זה לא עניין של כוח רצון, ואיך אפשר להתחיל להרגיש יציבות, הקלה ויותר שליטה מתוך הבנה של מה באמת קורה בגוף ובנפש. לפרטים על טיפולים אצלינו: http://rutifink.vp4.me/ebge למדריך מקיף חינם – איך להפסיק עם הנשנושים בערב: https://rutifink.vp4.me/night עקבו אחריי לעוד המון מידע חינמי: אינסטגרם: https://www.instagram.com/rutifink/ טיק-טוק: https://www.tiktok.com/@rutifink פייסבוק: https://www.facebook.com/fink.ruti יוטיוב: https://www.youtube.com/@rutifink לקבלת מייל בכל פעם שיוצא פרק חדש של הפודקאסט: http://rutifink.vp4.me/podcast רפרנסים: DOI:10.1017/S0033291724003581 DOI:10.1016/j.biopsych.2021.05.026 DOI: 10.1176/appi.ajp.2015.15020162 DOI: 10.1001/jamapsychiatry.2025.1858 DOI: 10.1016/S2215-0366(20)30099-7 DOI: doi:10.1016/j.bbr.2019.112041 DOI: doi:10.1016/j.jad.2019.03.015 DOI: 10.3390/nu15051173 DOI: 10.1016/j.appet.2024.107343 DOI: 10.1016/j.appet.2023.106510 DOI: 10.1016/j.appet.2018.02.022 DOI: 10.1016/j.appet.2016.02.034 DOI:10.1016/S2215-0366(20)30099-7
Dr Alexander Montoye is working as an Associate professor of Clinical Exercise Physiology at Alma College, Michigan, U.S. His main research area involves physical activity monitoring devices. He studies the accuracy and reliability of various physical activity monitors and also uses them as intervention tools to help individuals become more physically active. --- Advanced analytic methods (by other research groups), and a repository to make such models easier to find and use. Pfeiffer KA, Clevenger KA, Kaplan A, Van Camp CA, Strath SJ, Montoye AHK. Accessibility and use of novel methods for predicting physical activity and energy expenditure using accelerometry: A scoping review. Phys Meas. 2022; 43(9). DOI: 10.1088/1361-6579/ac89ca. Clevenger KA, Montoye AHK, Van Camp CA, Strath SJ, Pfeiffer KA. Methods for estimating physical activity and energy expenditure using raw accelerometry data or novel analytical approaches: A repository, framework, and reporting guidelines. Phys Meas. 2022; 43(9). DOI: 10.1088/1361-6579/ac89c9. _____________________ This podcast episode is sponsored by Fibion Inc. | Better Sleep, Sedentary Behaviour and Physical Activity Research with Less Hassle --- Collect, store and manage SB and PA data easily and remotely - Discover ground-breaking Fibion SENS --- SB and PA measurements, analysis, and feedback made easy. Learn more about Fibion Research --- Learn more about Fibion Sleep and Fibion Circadian Rhythm Solutions. --- Fibion Kids - Activity tracking designed for children. --- Collect self-report physical activity data easily and cost-effectively with Mimove. --- Explore our Wearables, Experience sampling method (ESM), Sleep, Heart rate variability (HRV), Sedentary Behavior and Physical Activity article collections for insights on related articles. --- Refer to our article "Physical Activity and Sedentary Behavior Measurements" for an exploration of active and sedentary lifestyle assessment methods. --- Learn about actigraphy in our guide: Exploring Actigraphy in Scientific Research: A Comprehensive Guide. --- Gain foundational ESM insights with "Introduction to Experience Sampling Method (ESM)" for a comprehensive overview. --- Explore accelerometer use in health research with our article "Measuring Physical Activity and Sedentary Behavior with Accelerometers ". --- For an introduction to the fundamental aspects of HRV, consider revisiting our Ultimate Guide to Heart Rate Variability. --- Follow the podcast on Twitter https://twitter.com/PA_Researcher Follow host Dr Olli Tikkanen on Twitter https://twitter.com/ollitikkanen Follow Fibion on Twitter https://twitter.com/fibion https://www.youtube.com/@PA_Researcher
Episode Overview In this episode, Dr. David Rosenblum discusses the role of supplements and complementary strategies in the management of chronic pain. Drawing from clinical practice at AABP Integrative Pain Care, as well as his teaching and training programs, Dr. Rosenblum reviews how nutraceuticals, regenerative therapies, ultrasound-guided procedures, and neuromodulation can work together to improve patient outcomes and reduce opioid reliance. This episode also highlights educational opportunities and exam-prep resources for pain fellows, residents, anesthesiologists, physiatrists, and APPs looking to expand their interventional pain, ultrasound, and regenerative medicine skill sets. Key Topics Discussed Evidence and clinical rationale for select supplements in chronic pain management The role of ultrasound guidance in improving accuracy and safety in interventional pain procedures How regenerative medicine techniques such as PRP and BMAC are shaping personalized pain care Practical considerations when combining supplements with neuromodulation, RFA, or injections Patient case applications and real-world treatment planning Educational Offerings & Learning Opportunities PainExam / NRAP Academy Training & Programs: Neuromodulation & Regional Anesthesia Workshops Ultrasound-Guided Pain Procedures Regenerative Pain Medicine Training Virtual Pain Fellowship Pain Management Board Review & Question Banks Learn More / Register: www.AABPpain.com
BUFFALO, NY – November 18, 2025 – A new #review was #published in Oncotarget (Volume 16) on November 14, 2025, titled “Mechanism of anticancer action of bifidobacterium: Insights from gut microbiota.” This review, led by first author Hoang Do and correspondent author Ashakumary Lakshmikuttyamma from Thomas Jefferson University, explores how bifidobacterium, a common probiotic found in the gut, may contribute to cancer prevention and therapy. By analyzing existing studies, the authors highlight the growing importance of gut health in cancer treatment and shed light on how bifidobacterium could complement standard cancer therapies. Bifidobacterium is widely known for promoting digestive health and is often included in fermented foods and dietary supplements. However, emerging evidence suggests it may also play a broader role in immune regulation and cancer defense. The review explains how certain strains of bifidobacterium may enhance the effectiveness of chemotherapy, radiation, and immunotherapy in cancers such as breast, lung, colorectal, and gastric cancers. According to the review, bifidobacterium influences cancer outcomes through several biological mechanisms. It helps regulate immune function by reducing inflammation and supporting the activity of immune cells that target tumors. For instance, strains like B. longum and B. breve have been shown to lower levels of harmful inflammatory markers and boost anti-inflammatory responses. These changes can make cancer treatments more effective while also reducing side effects. “Presence of Bifidobacterium breve in gut microbiota extended the median progression-free survival of NSCLC patients.” The review also discusses how bifidobacterium helps detoxify the body by breaking down cancer-causing compounds and limiting their ability to damage cells. In preclinical studies, the probiotic reduced the activity of enzymes that produce carcinogens and helped in converting food-based substances into cancer-fighting agents. Some strains were even found to suppress genes that promote tumor growth and increase molecules that trigger cancer cell death. The authors emphasize that diet plays a critical role in supporting the growth of bifidobacterium. Foods rich in dietary fiber, especially those containing inulin and oligosaccharides like garlic, onions, or leeks, can help increase its levels in the gut. This suggests that simple dietary changes could not only improve gut health but also support cancer prevention and treatment strategies. Although the review presents compelling evidence, the authors stress the need for more clinical trials to determine how different strains of bifidobacterium affect specific types of cancer. Personalized approaches may be necessary to match the right probiotic strains with individual treatment plans. As research continues to uncover the link between gut microbes and cancer, bifidobacterium stands out as a promising natural ally that could enhance the body's defenses and improve cancer treatment outcomes. DOI - https://doi.org/10.18632/oncotarget.28779 Correspondence to - Ashakumary Lakshmikuttyamma - axl025@jefferson.edu Abstract video - https://www.youtube.com/watch?v=KTWJDAN15lY Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28779 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM
Podcast Family, we have covered the subject of Measles previously on this show (links below). Those episodes were a preview of what has now been released ahead of print as a narrative review in the Green Journal! In this episode, we will summarize the KEY points of measles infection in pregnancy and re-state the “rule of 4” and the importance of the number 10 regarding this.1. Feb 24, 2025: Measles 101: https://open.spotify.com/episode/4lXrpqKTJPdDcTXPxpEmcb2. April 27, 2019: Measles!! ACOG Practice Advisory: https://creators.spotify.com/pod/profile/dr-hector-chapa/episodes/MEASLES---ACOG-practice-advisory-e3s1p43. Joseph, Naima T. MD, MPH. Measles in Pregnancy: Clinical Considerations and Challenges. Obstetrics & Gynecology ():10.1097/AOG.0000000000006126, November 14, 2025. | DOI: 10.1097/AOG.0000000000006126
Research from Asian geckos generally suggests that sticky pads are used for smooth surfaces, while claws help grip onto rougher surfaces like wood and rocks. But a new study using Australian geckos is has turned that paradigm upside-down. Then we talk about a brand new species of frog described from the mountains of central China. Become a Patreon: https://www.patreon.com/herphighlights Merch: https://www.redbubble.com/people/herphighlights/shop Full reference list available here: http://www.herphighlights.podbean.com Main Paper References: Pillai RR, Riedel J, Wirth W, Allen-Ankins S, Nordberg E, Edwards W, Schwarzkopf L. 2025. What's the point? The functional role of claws in pad-bearing taxa (Gekkota: Diplodactylidae). Proceedings of the Royal Society B: Biological Sciences 292:20251362. DOI: 10.1098/rspb.2025.1362. Species of the Bi-Week: Li S, Shi S, Liu J, Zhao J, Gao S, Wang B. 2025. A new species of the Boulenophrys (Anura, Megophryidae) from Hubei, China. Zoosystematics and Evolution 101:1213–1226. DOI: 10.3897/zse.101.155859. Other Mentioned Papers/Studies: GEORGALIS, G. L., & JONES, M. E. (2025). A new peculiar early diverging caenophidian snake (Serpentes) from the late Eocene of Hordle Cliff, England. Comptes Rendus Palevol, 24(25), 505-530. Editing and Music: Intro/outro – Treehouse by Ed Nelson Species Bi-week theme – Michael Timothy Other Music – The Passion HiFi, https://www.thepassionhifi.com
BUFFALO, NY – November 17, 2025 – A new #research perspective was #published in Oncotarget (Volume 16) on November 14, 2025, titled “A personal perspective of patient-centred clinical trials.” In this perspective, led by corresponding author Jia Liu of The Kinghorn Cancer Centre, St Vincent's Hospital, the University of New South Wales, and the Garvan Institute of Medical Research, three early-phase clinical trial participants — Trevor Tyne, Elizabeth Ivimey, and Leanne Duggan — reflect on their personal experiences with experimental cancer treatments. Their stories offer a unique perspective on the patient journey through early-phase trials and emphasize the need to design clinical research that prioritizes patients' needs, dignity, and lived realities. The authors highlight both the life-changing opportunities that trials can provide and the systemic barriers that still prevent many patients from participating. This perspective captures a turning point in how early-phase trials are viewed. Once considered a last resort, these trials are now increasingly offered earlier in treatment, especially with the rise of biomarker-guided therapies. In this context, the patient experience has become critical. The authors outline key benefits of participation, including access to novel therapies, ongoing medical monitoring, emotional support, and a strong sense of purpose in contributing to future medical advancements. However, they also point out significant challenges, such as restrictive eligibility criteria, high financial and logistical burdens, and communication gaps between patients and trial staff. “While no trial guarantees success, the level of support, access to innovative therapies, and sense of contribution to medical progress can be profoundly meaningful.” Each narrative provides insight into the clinical trial experience. One patient explains how living with a visual impairment required tailored accessibility support throughout the trial process Another shares how genomic testing led to targeted treatment after standard options failed. Despite their different diagnoses and circumstances, all three stories reflect resilience, hope, and a shared call for trial designs that better reflect the realities of diverse patients. To address these issues, the authors propose a number of improvements to trial design and delivery. These include expanding eligibility criteria, offering financial and logistical assistance, improving communication training for research staff, and introducing dedicated trial navigators to help guide patients through complex processes. They also focus on the importance of involving patient advocates in trial design and ensuring smoother transitions for patients moving between treatment centers. While early-phase trials focus on safety and effectiveness, the authors argue they must also be guided by core values like ethics and patient empowerment. This perspective serves as a reminder that the future of cancer research depends not only on scientific innovation, but on an honest partnership between patients and the research community. By sharing these real-world experiences, the article encourages a broader conversation about how to make clinical trials more responsive to the people they are designed to serve. DOI - https://doi.org/10.18632/oncotarget.28776 Correspondence to - Jia Liu - jia.liu@svha.org.au Abstract video - https://www.youtube.com/watch?v=2CCGN78n8ug To learn more about Oncotarget, visit https://www.oncotarget.com: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM
Dr Alexander Montoye is working as an Associate professor of Clinical Exercise Physiology at Alma College, Michigan, U.S. His main research area involves physical activity monitoring devices. He studies the accuracy and reliability of various physical activity monitors and also uses them as intervention tools to help individuals become more physically active. --- Advanced analytic methods (by other research groups), and a repository to make such models easier to find and use. Pfeiffer KA, Clevenger KA, Kaplan A, Van Camp CA, Strath SJ, Montoye AHK. Accessibility and use of novel methods for predicting physical activity and energy expenditure using accelerometry: A scoping review. Phys Meas. 2022; 43(9). DOI: 10.1088/1361-6579/ac89ca. Clevenger KA, Montoye AHK, Van Camp CA, Strath SJ, Pfeiffer KA. Methods for estimating physical activity and energy expenditure using raw accelerometry data or novel analytical approaches: A repository, framework, and reporting guidelines. Phys Meas. 2022; 43(9). DOI: 10.1088/1361-6579/ac89c9. _____________________ This podcast episode is sponsored by Fibion Inc. | Better Sleep, Sedentary Behaviour and Physical Activity Research with Less Hassle --- Collect, store and manage SB and PA data easily and remotely - Discover ground-breaking Fibion SENS --- SB and PA measurements, analysis, and feedback made easy. Learn more about Fibion Research --- Learn more about Fibion Sleep and Fibion Circadian Rhythm Solutions. --- Fibion Kids - Activity tracking designed for children. --- Collect self-report physical activity data easily and cost-effectively with Mimove. --- Explore our Wearables, Experience sampling method (ESM), Sleep, Heart rate variability (HRV), Sedentary Behavior and Physical Activity article collections for insights on related articles. --- Refer to our article "Physical Activity and Sedentary Behavior Measurements" for an exploration of active and sedentary lifestyle assessment methods. --- Learn about actigraphy in our guide: Exploring Actigraphy in Scientific Research: A Comprehensive Guide. --- Gain foundational ESM insights with "Introduction to Experience Sampling Method (ESM)" for a comprehensive overview. --- Explore accelerometer use in health research with our article "Measuring Physical Activity and Sedentary Behavior with Accelerometers ". --- For an introduction to the fundamental aspects of HRV, consider revisiting our Ultimate Guide to Heart Rate Variability. --- Follow the podcast on Twitter https://twitter.com/PA_Researcher Follow host Dr Olli Tikkanen on Twitter https://twitter.com/ollitikkanen Follow Fibion on Twitter https://twitter.com/fibion https://www.youtube.com/@PA_Researcher
It's World AMR Awareness Week (WAAW) and we have prepared a special episode in light of that. In this week's Communicable, Navaneeth Narayanan and Thomas Tängdén host Aula Abbara (London, UK), Guido Granata (Rome, Italy) and Tuomas Aro (Helsinki, Finland) to discuss the phenomenon of AMR in conflict and crisis zones. They elaborate on how difficult conditions and austere environments amplify the spread of AMR, drawing on findings from the ongoing conflicts in Ukraine, Gaza, Syria and other regions. Other topics covered include adapting antimicrobial stewardship and infection prevention and control (IPC) practices as well as the need for genuine political will and international collaboration to end conflicts and their exacerbation on AMR.This episode follows the webinar “Beyond the frontlines” organised by ESCMID's AMR Action Subcommittee for WAAW 2025, featuring the same guests, and is available on ESCMID Media. This Communicable episode was peer reviewed by Arjana Zerja of Mother Theresa University Hospital Centre, Tirana, Albania. Related ESCMID and Communicable mediaESCMID Media, Part 1: Beyond the frontlines - tackling AMR in conflict and crisis zones, webinar Communicable episode 11: Nightmare series, part 2 – how to deal with carbapenemase producers Communicable episode 16: Climate change and infections – effects on clinical practice & sustainabilityResourcesTrainee Association of ESCIMD (TAE) Doctors without Borders (Médecins sans Frontières), Antibiogo, https://www.antibiogo.org/Doctors without Borders (Médecins sans Frontières), Mini-lab, https://fondation.msf.fr/en/projects/mini-lab Further ReadingAbbara A, et al. Unravelling the linkages between conflict and antimicrobial resistance. NPJ Antimicrob Resist. 2025. DOI: 10.1038/s44259-025-00099-yAbbara A, et al. A summary and appraisal of existing evidence of antimicrobial resistance in the Syrian conflict. Int J Infect Dis. 2018. DOI: 10.1016/j.ijid.2018.06.010Abu-Shomar R, et al. Multidrug-resistant Pseudomonas isolated from water at primary health care centers in Gaza, Palestine: a cross-sectional study. IJID Reg. 2025. DOI: 10.1016/j.ijregi.2025.100671Aldbis A, et al. The lived experience of patients with conflict associated injuries whose wounds are affected by antimicrobial resistant organisms: a qualitative study from northwest Syria. Confl Health. 2023. DOI: 10.1186/s13031-023-00501-4Aro T, et al. War on antimicrobial resistance: high carriage rates of multidrug-resistant bacteria among war-injured Ukrainian refugees. Clin Microbiol Infect. 2025. DOI: 10.1016/j.cmi.2025.07.010 Bazzi W, et al. Heavy Metal Toxicity in Armed Conflicts Potentiates AMR in A. baumannii by Selecting for Antibiotic and Heavy Metal Co-resistance Mechanisms. Front Microbiol. 2020. DOI: 10.3389/fmicb.2020.00068 Dewachi O. War Biology and Antimicrobial Resistance: The Case of Gaza, AMR Insights, 2024.Granata G, et al. The impact of armed conflict on the development and global spread of antibiotic resistance: a systematic review. Clin Microbiol Infect. 2024. DOI: 10.1016/j.cmi.2024.03.029 Huang XZ, et al. Molecular analysis of imipenem-resistant Acinetobacter baumannii isolated from US service members wounded in Iraq, 2003-2008. Epidemiol Infect. 2012. DOI: 10.1017/S0950268811002871Hujer KM, et al. Analysis of antibiotic resistance genes in multidrug-resistant Acinetobacter sp. isolates from military and civilian patients treated at the Walter Reed Army Medical Center. Antimicrob Agents Chemother. 2006. DOI: 10.1128/AAC.00778-06Karah N, et al. Teleclinical Microbiology: An Innovative Approach to Providing Web-Enabled Diagnostic Laboratory Services in Syria. Am J Clin Pathol. 2022. DOI: 10.1093/ajcp/aqab160Keen EF 3rd, et al. Evaluation of potential environmental contamination sources for the presence of multidrug-resistant bacteria linked to wound infections in combat casualties. Infect Control Hosp Epidemiol. 2012. DOI: 10.1086/667382Murray CK, et al. Recovery of multidrug-resistant bacteria from combat personnel evacuated from Iraq and Afghanistan at a single military treatment facility. Mil Med. 2009. DOI: 10.7205/milmed-d-03-8008Petersen K, et al. Diversity and clinical impact of Acinetobacter baumannii colonization and infection at a military medical center. J Clin Microbiol. 2011. DOI: 10.1128/JCM.00766-10Scott P, et al. An outbreak of multidrug-resistant Acinetobacter baumannii-calcoaceticus complex infection in the US military health care system associated with military operations in Iraq. Clin Infect Dis. 2007. DOI: 10.1086/518170Sensenig RA, et al. Longitudinal characterization of Acinetobacter baumannii-calcoaceticus complex, Klebsiella pneumoniae, and methicillin-resistant Staphylococcus aureus colonizing and infecting combat casualties. Am J Infect Control. 2012. DOI: 10.1016/j.ajic.2011.03.025World Health Organization. Fourth WHO Global Evidence Review on Health and Migration stresses that equitable access to and appropriate use of antibiotics for refugees and migrants is essential to tackling Antimicrobial Resistance, News, 2022.
Vorlesungen zur Linguistik und Sprachgeschichte des Deutschen
Diese Vorlesung bietet eine umfassende Einführung in die aktuellen Entwicklungen der Konstruktionsgrammatik, eine der zentralen Theorien der kognitiven Linguistik. Im Mittelpunkt steht die Annahme, dass Sprache aus „Konstruktionen“ besteht – konventionalisierten Paarungen von Bedeutung und Form. Die Vorlesung wird durch zwei Schwerpunktsetzungen gekennzeichnet sein. Zum einen ist das die enge Verbindung der Konstruktionsgrammatik mit der Framesemantik. Die Framesemantik kann konstruktionelle Analysen ideal ergänzen, indem sie die konzeptuellen Grundlagen sprachlicher Bedeutung detailliert erschließt. Wir untersuchen, wie Konstruktionen und Frames, Wissensrahmen, in Relation zueinander stehen. Zum anderen widmet sich die Vorlesung der Konstruktikographie. Dieses Gebiet verbindet die theoretischen Erkenntnisse der Konstruktionsgrammatik mit den Methoden der praktischen Lexikographie, um „Konstruktika“ – umfassende Verzeichnisse von Konstruktionen – zu beschreiben. Wir werden Ziele und Methoden der Konstruktikographie erörtern, einschließlich korpusbasierter Workflows, Annotationspraktiken und der Strukturierung von Konstruktionsbeschreibungen.Präsentation (*.pdf): Alexander Lasch. 2025. Konstruktionsgrammatik. Zenodo. DOI: https://doi.org/10.5281/zenodo.17370032. Videoaufzeichnungen: https://youtube.com/@AlexanderLasch. Informationen & Material zu allen Vorlesungen: https://kurzelinks.de/fl7f. Worksheet zu den Vorlesungen: https://kurzlinks.de/WorksheetVorlesungen. Intro: "Reflections" von Scott Holmes (CC BY via FMA).#Linguistik #OER #Sprache #Sprachwissenschaft #Grammatik #Konstruktionsgrammatik
What is the main driver of sex differences in heart failure with reduced ejection fraction (HFrEF)? In our latest episode, Associate Editor Dr. Petra Kleinbongard (University of Duisburg-Essen) interviews lead author Dr. Matthieu Ruiz (Montreal Heart Institute) and expert Dr. Catherine Mounier (Université du Québec à Montréal) about the new study by David et al. that explores sex-specific effects of B-vitamin supplementation on heart failure with reduced ejection fraction in mice subjected to pressure overload. The research by Ruiz and co-authors found that B-vitamins improved survival rates, cardiac function, and reduced fibrosis in female mice. However, male mice exhibited persistent inflammation, fibrosis, and unfavorable lipidome remodeling despite the B-vitamin supplementation. The findings underscore the sex-specific benefits of B-vitamins in heart failure, and confirm the importance of animal models of human disease for clinical translation. Listen now and learn more. Chloé David, Sonia Deschênes, Gabriel Ichkhan, Caroline Daneault, Isabelle Robillard Frayne, Bertrand Bouchard, Anik Forest, Yan Fen Shi, Marie-Ève Higgins, Martin G. Sirois, Jean-Claude Tardif, Mathias Mericskay, Jérôme Piquereau, and Matthieu Ruiz Sex-Specific Modulation of Cardiac Fibrosis and Lipid Metabolism by B-Vitamins in Heart Failure with Reduced Ejection Fraction in Mice Am J Physiol Heart Circ Physiol, published June 12, 2025. DOI: 10.1152/ajpheart.00841.2024
Mapping the Landscape of Technical Standards: A Nationwide Review of Medical Schools Interviewees: Carol Haywood, PhD, OTR/L — Assistant Professor, Medical Social Sciences, Northwestern University Feinberg School of Medicine Chris Moreland, MD, MPH — Professor of Internal Medicine; Division Chief for Hospital Medicine; Interim Associate Chair for Faculty Affairs and Development, Dell Medical School (Comments made in ASL and voiced through interpreters) Interviewer: Lisa Meeks, PhD, MA — Guest Editor, Academic Medicine Supplement on Disability Inclusion in Undergraduate Medical Education Description: In this episode of Stories Behind the Science, we sit down with Dr. Carol Haywood and Dr. Chris Moreland to explore a deceptively powerful document: the medical school technical standards. These quietly influential statements—often tucked deep in an admissions webpage—shape who feels welcome to apply, who gains access, and how institutions imagine the future of their profession. Haywood and Moreland, co-authors of a national analysis featured in the Academic Medicine supplement on Disability Inclusion in Undergraduate Medical Education, unpack what happens when ambiguous language, outdated assumptions, and vague expectations collide with real people making real decisions about their careers. Together, they dig into the nuances of functional vs. organic standards, the importance of clarity for applicants who lack insider knowledge, and the ripple effects of inequitable policies across a learner's entire training experience. What emerges is both sobering and hopeful: a field undergoing change, a growing recognition that words matter, and a roadmap for institutions ready to bring their values into alignment with their practices. The discussion reviews: How technical standards became a gatekeeper—and why revising a single sentence can shift an entire culture. Why students with disabilities read these documents differently—and why that matters for equity. How ambiguity in admissions can deter talented future physicians long before they step foot in a classroom. What schools can do now to create standards that prioritize competence, flexibility, and inclusion. Dr. Haywood brings a researcher's lens and an occupational therapist's creativity to the conversation, illuminating how functional expectations—not assumptions about bodies—should guide medical training. Dr. Moreland shares deeply personal reflections on navigating technical standards as a deaf physician, offering rare insight into how these documents land on applicants with lived experience. This episode invites the audience to imagine a medical education landscape where technical standards do what they should do—define competence, set expectations, and open doors—rather than unintentionally closing them. Bios: Carol Haywood, PhD, OTR/L, is Assistant Professor of Medical Social Sciences in the Determinants of Health Division and core faculty in the Center for Health Services and Outcomes Research at Northwestern University Feinberg School of Medicine in Chicago, IL. Building from her work as an occupational therapist in acute rehabilitation, she completed a PhD in occupational science at the University of Southern California and a postdoctoral fellowship in health services and outcomes research at Northwestern University. Using qualitative, mixed methods, and community-engaged research approaches, she studies disability in a variety of contexts, as well as health care access, coordination, and quality. She is driven by a vision of health care that facilitates equity for people with disabilities. Chris Moreland, MD MPH, is a professor of medicine, interim associate department chair for faculty affairs, and division chief for hospital medicine at Dell Medical School at UT Austin. He practices clinically as a hospitalist. As a career-long clinician educator, his teaching has been recognized regionally and nationally. His collaborative advocacy and research efforts describe the experiences of our healthcare workforce and learners with disabilities, as well as strategies to foster pathways to thriving clinicians. He has served as president and longtime board member for the Association of Medical Professionals with Hearing Losses; he holds current roles on the Docs with Disabilities Initiative advisory board, the AAMC Group on Diversity and Inclusion steering committee, and as a consultant with the National Deaf Center. Transcript: https://docs.google.com/document/d/18hUPguWf_jWeDC1fmOgSKSXPv4xGnkQIPUi3zhfH540/edit?usp=sharing Resources: Singer, Tracey; Madanguit, Lance MD; Fok, King T. MD, MSc; Stauffer, Catherine E. MD; Meeks, Lisa M. PhD, MA; Moreland, Christopher J. MD, MPH; Huang, Lynn MS; Case, Benjamin MPH; Lagu, Tara MD, MPH; Kannam, Allison MD; Haywood, Carol PhD, OTR/L. Mapping the Landscape of Technical Standards: A Nationwide Review of Medical Schools. Academic Medicine 100(10S):p S144-S151, October 2025. | DOI: 10.1097/ACM.0000000000006135 McKee, M.M., Gay, S., Ailey, S., Meeks, L.M. (2020). Technical Standards. In: Meeks, L., Neal-Boylan, L. (eds) Disability as Diversity. Springer, Cham. https://doi.org/10.1007/978-3-030-46187-4_9 Equal Access for Students with Disabilities: The Guide for Health Science and Professional Education (2nd Ed). Meeks LM, Jain NR, & Laird EP. Springer Publishing, 2020. Key Words: Disability inclusion · Technical standards · Medical education · Admissions · Accessibility · Equity · Policy reform
Well, from time to time we cover RANDOM tidbits of information which cover RANDOM questions and/or RANDOM patient care issues that we encounter. In this episode we will cover one OB issue related to recurrent pregnancy loss, one GYN issue related to unilateral breast swelling in a patient with SLE, and one RANDOM life perspective response from a mock interview that I participated in for a residency candidate. Listen in fordetails!1. Viviana DO; Giugni, Claudio Schenone MD; Ros, Stephanie T. MD, MSCI. Factor V and recurrent pregnancy loss: de Assis, Evaluation of Recurrent Pregnancy Loss. Obstetrics & Gynecology 143(5):p 645-659, May 2024. | DOI: 10.1097/AOG.0000000000005498Unilateral Breast Swelling with SLE: 2. Voizard B, Lalonde L, Sanchez LM, et al. LupusMastitis as a First Manifestation of Systemic Disease: About Two Cases With a Review of the Literature. European Journal of Radiology. 2017;92:124-131. doi:10.1016/j.ejrad.2017.04.023.3. Kinonen C, Gattuso P, Reddy VB. Lupus Mastitis:An Uncommon Complication of Systemic or Discoid Lupus. The American Journal of Surgical Pathology. 2010;34(6):901-6. doi:10.1097/PAS.0b013e3181da00fb.4. Summers TA, Lehman MB, Barner R, Royer MC. Lupus Mastitis: A Clinicopathologic Review and Addition of a Case. Advances in Anatomic Pathology.2009;16(1):56-61. doi:10.1097/PAP.0b013e3181915ff7.5. Jiménez-Antón A, Jiménez-Gallo D,Millán-Cayetano JF, Navarro-Navarro I, Linares-Barrios M. Unilateral Lupus Mastitis.Lupus. 2023;32(3):438-440. doi:10.1177/09612033221151011.STRONG COFFEE PROMO: 20% Off Strong Coffee Company https://strongcoffeecompany.com/discount/CHAPANOSPINOBG
BUFFALO, NY - November 12, 2025 – A new #research paper was #published in Oncotarget (Volume 16) on November 6, 2025, titled “LRIG1-3 in gliomas: LRIG1 protein expression decreased in higher grade gliomas.” In this study by Marlene Happe, Saskia Kuhl, Lukas Görtz, Roland Goldbrunner and Marco Timmer, from the University of Cologne, researchers found that the LRIG1 protein, which may help suppress tumors, is present at lower levels in more aggressive gliomas, a type of brain tumor. The findings suggest that LRIG1 could serve as a useful marker for tumor severity and potentially as a target for future therapies. Gliomas are the most common malignant brain tumors in adults and carry a poor prognosis, particularly in their most severe form, glioblastoma. This study investigated three related proteins: LRIG1, LRIG2, and LRIG3, which are involved in regulating cell growth signals. While LRIG1 and LRIG3 have shown tumor-suppressing effects in previous studies, LRIG2 is thought to support tumor growth. The researchers analyzed tumor samples from patients to understand how these proteins behave across different glioma grades and how they respond to chemotherapy. The results showed that LRIG1 protein levels decline significantly as tumor grade increases. Low-grade gliomas displayed much higher LRIG1 expression than high-grade tumors. Among high-grade tumors, primary glioblastomas had the lowest levels of LRIG1. Interestingly, secondary glioblastomas, which typically develop from lower-grade tumors, had higher levels of LRIG1 than primary glioblastomas. This difference may contribute to their relatively better clinical outcomes. These results highlight LRIG1's potential role in slowing tumor progression. In contrast, LRIG2 showed a more complex pattern. While its gene expression was higher in lower-grade tumors, the actual protein levels were slightly elevated in higher-grade ones, which are more aggressive. This mismatch suggests that processes occurring after gene transcription may influence how much LRIG2 protein is produced. “However, our data on LRIG2 indicate that its role in glioma may be more complex than previously thought, warranting further investigation.” Concerning LRIG3, it was found in higher amounts in glioma tissue compared to surrounding healthy tissue. Its expression was particularly high in low-grade tumors. However, chemotherapy did not consistently affect LRIG3 levels, and results varied depending on tumor type and treatment status. Overall, the study suggests that members of the LRIG protein family, especially LRIG1, could serve as important biomarkers to distinguish between glioma types and grades. Although chemotherapy did not significantly change their expression in most cases, these proteins have high potential as diagnostic tools or therapeutic targets. Further research is needed to better understand their roles in glioma development and treatment response. DOI - https://doi.org/10.18632/oncotarget.28775 Correspondence to - Marco Timmer - marco.timmer@uk-koeln.de Abstract video - https://www.youtube.com/watch?v=ZHsKLBEyBbM Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28775 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, oncology, glioma, glioblastoma, LRIG1, LRIG2, LRIG3 To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM
Send us a textA classroom can be a launchpad for climate action when reading meets real life. We sit down with Miami-area educator Catherine Manfra to explore how English language arts becomes a powerful space for climate literacy, creative expression, and student agency—especially in a region living with hurricanes, sea-level rise, and rapid development at the edge of the Everglades.Catherine walks us through her Earth Day unit anchored by Hope Jahren's The Story of More and climate-focused poetry, showing how accessible science writing invites teens into complex topics without overwhelming them. From lunchroom showcases to one-minute PSAs, her students translate facts into story, practice tight writing and media literacy, and share concrete steps that counter defeatism. We also unpack how giving students information and choice sparks deeper research, community involvement, and everyday action.Beyond the classroom, we highlight the Stories-To-Live-By collective, a statewide network of teachers and researchers crafting place-based, multimodal approaches to climate education while navigating book bans and shifting policies. Catherine shares how the group's workshops and shared resources build confidence. She also talks about how the Fairchild Challenge debate strengthens ELA standards, STEM integration, and civic discourse by asking students to argue multiple sides of timely environmental issues. It's a hopeful blueprint for educators who want rigorous, inclusive climate literacies that prepare young people for a just, livable future.If this conversation resonates, follow the show, share it with a colleague, and leave a review with your favorite climate literacy text or project idea. Your feedback helps us bring more teacher-tested practices to more classrooms.Catherine is a Florida native. Born in Hialeah, a suburb of Miami with a predominantly Hispanic community, she now lives in the Kendall area just south of Miami. She has seen Miami-Dade County continue to expand westward since her childhood, including encroachment on the Florida Everglades. The Florida Everglades are ecologically significant in their role as a subtropical wilderness, a habitat for many threatened and endangered species, and a provider of flood control, water filtration, and freshwater supply for millions of people. She became a part of the Stories-To-Live-By project by answering an initial online survey of teachers who incorporate environmental topics into their curriculum. After teaching all levels of high school English in public schools in Miami-Dade County for 22 years, Catherine now teaches at Palmer Trinity School, an independent private school. Additionally, Catherine is a part of the Junior League of Miami, a women's group that serves and focuses on women's and children's issues in the community from education to safety. To cite this episode: Persohn, L. (Host). (2025, Oct 14). A Stories-To-Live-By Conversation with Catherine Manfra. (Season 6, No. 4) [Audio podcast episode]. In Classroom Caffeine Podcast series. https://www.classroomcaffeine.com/guests. DOI: 10.5240/33A8-951D-21CD-B5CE-9F8A-BConnect with Classroom Caffeine at www.classroomcaffeine.com or on Instagram, Facebook, Twitter, and LinkedIn.
This week we're traveling back to 18th-century France with Perfume: The Story of a Murderer! Join us as we learn about tanneries, the town of Grasse, infanticide, perfumers' guilds, and more! Sources: https://www.rogerebert.com/reviews/perfume-the-story-of-a-murderer-2007 https://www.rottentomatoes.com/m/perfume_the_story_of_a_murderer https://en.wikipedia.org/wiki/Perfume:_The_Story_of_a_Murderer_%28film%29 A.O. Scott, https://www.nytimes.com/2006/12/27/movies/27perf.html Tracey Rizzo (2004) Between dishonor and death: infanticides in the causes célèbres of eighteenth-century France, Women's History Review, 13:1, 5-22, DOI: 10.1080/09612020400200380 Arhoune, Ilham@, Impact of Chemicals and Working Conditions on Tannery Workers' Health and Recommendations for Improving the Situation. Available at SSRN: https://ssrn.com/abstract=5347318 or http://dx.doi.org/10.2139/ssrn.5347318 " 1. Rabbani G, Billah B, Giri A, et al. Factors Associated With Health Complaints Among Leather Tannery Workers in Bangladesh. Workplace Health & Safety. 2020;69(1):22-31. doi:10.1177/2165079920936222 " https://montecristomagazine.com/beauty/medieval-tannery-town-french-riviera-became-perfume-capital-world#gsc.tab=0 https://www.tfcg.ca/old-occupation-tanner Kirsten James, The Science of Scent and Business of Perfume in Paris and London, 1650-1815, PhD thesis, University of Toronto (2019). Eleanor Beardsley, "Sick Of Tanneries' Stench Centuries Ago, A French Town Began Making Perfume. It Stuck." NPR, available at https://www.npr.org/2021/09/21/1039393853/sick-of-tanneries-stench-centuries-ago-a-french-town-began-making-perfume-it-stu Luxus Magazine, Grasse: World Capital of Perfume: https://magazine.luxus-plus.com/en/brief-history-of-luxury-grasse-world-capital-of-perfume/
Mindfulness Training and Stress Reactivity in Substance Abuse: Results from a Randomized, Controlled Stage I Pilot StudyIn this episode, Dr. Jud delves into groundbreaking research comparing mindfulness training (MT) and cognitive behavioral therapy (CBT) for individuals with substance use disorders. This pilot study investigates the role of mindfulness in managing stress and addiction, highlighting its potential to reduce psychological and physiological stress responses. Learn how MT could become a viable treatment option alongside traditional therapies, the challenges faced during the study, and what these findings mean for the future of addiction treatment.Reference: Brewer, J. A., Sinha, R., Chen, J. A., Michalsen, R. N., Babuscio, T. A., Nich, C., ... & Rounsaville, B. J. (2009). Mindfulness Training and Stress Reactivity in Substance Abuse: Results from a Randomized, Controlled Stage I Pilot Study. Substance Abuse, 30(4), 306-317. DOI: 10.1080/08897070903250241Let's connect on Instagram
This week we speak with Ohio State ACHD fellow Andrew Freddo MD, PhD about a recent large single center study he conducted assessing the cardiovascular drugs that adult Fontan patients are taking and whether they might offer us insights into general well-being. Are there agents that are associated with worse outcomes? If so, is this a situation of the agent causing harm or is it a possible marker of illness? Are there agents associated with improved outcomes? These are amongst the questions reviewed with Dr. Freddo this week. DOI: 10.1016/j.jacadv.2025.102070
Taking folic acid prior to conception and during pregnancy can help protect the unborn baby from developing abnormalities. Supplements are particularly important for women who have epilepsy, as anti-seizure medication (previously known as anti-convulsants or anti-epileptic drugs) can lead to a deficiency in folic acid. Until 2023, high doses of 4-5 mg per day were recommended. However, this has changed as the data has changed. Did you know the SMFM no longer recommends “high dose” folic acid preconceptionally for patients on seizure medications? This is also highlighted in a recently released epub from Obstetrics and Gynecology (Green Journal) on October 31, 2025. Listen in for details. 1. Mokashi, Mugdha MD, MPH; Cozzi-Glaser, Gabriella MD; Kominiarek, Michelle A. MD, MS. Dietary Supplements in the Perinatal Period. Obstetrics & Gynecology ():10.1097/AOG.0000000000006098, October 31, 2025. | DOI: 10.1097/AOG.00000000000060982. Asadi-Pooya AA. High dose folic acid supplementation in women with epilepsy: are we sure it is safe? Seizure. 2015 Apr;27:51-3. doi: 10.1016/j.seizure.2015.02.030. Epub 2015 Mar 7. PMID: 25891927.3. https://aesnet.org/about/aes-press-room/press-releases/guideline-issued-for-people-with-epilepsy-who-may-become-pregnant4. Turner C, McIntosh T, Gaffney D, Germaine M, Hogan J, O'Higgins A. A 10-year review of periconceptual folic acid supplementation in women with epilepsy taking antiseizure medications. J Matern Fetal Neonatal Med. 2025 Dec;38(1):2524094. doi: 10.1080/14767058.2025.2524094. Epub 2025 Jun 30. PMID: 40588438.5. https://www.aan.com/PressRoom/Home/PressRelease/5170#:~:text=The%20guideline%20recommends%20that%20people,and%20possibly%20improve%20neurodevelopmental%20outcomes.6. https://aesnet.org/about/aes-press-room/press-releases/guideline-issued-for-people-with-epilepsy-who-may-become-pregnant
Back on August 9, 2024, we released an episode (link in the show notes) reviewing the renewed interest in transfusing whole blood for PPH rather than component therapy. Now, in O&G open, authors from my Alma Mater (UT Southwestern) have published new data bolstering the use of whole blood for PPH. Listen in for details.1. Clinical Pearls Episode 2024: https://open.spotify.com/episode/0ZhqoIE9wMcAboDlevq9OW?si=rM32uK8ER8uuWmq4mf5dzA2. Ambia, Anne M. MD; Burns, R. Nicholas MD; White, Alesha MD; Warncke, Kristen MD; Gorman, April MS; Duryea, Elaine MD; Nelson, David B. MD. Whole Blood in the Management of Postpartum Hemorrhage. O&G Open 2(5):e130, October 2025. | DOI: 10.1097/og9.00000000000001303. ACPG PB 183STRONG COFFEE PROMO: 20% Off Strong Coffee Company https://strongcoffeecompany.com/discount/CHAPANOSPINOBG
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