Podcasts about DOI

Podcast Family, we have covered the subject of Measles previously on this show (links below). Those episodes were a preview of what has now been released ahead of print as a narrative review in the Green Journal! In this episode, we will summarize the KEY points of measles infection in pregnancy and re-state the “rule of 4” and the importance of the number 10 regarding this.1. Feb 24, 2025: Measles 101: https://open.spotify.com/episode/4lXrpqKTJPdDcTXPxpEmcb2. April 27, 2019: Measles!! ACOG Practice Advisory: https://creators.spotify.com/pod/profile/dr-hector-chapa/episodes/MEASLES---ACOG-practice-advisory-e3s1p43. Joseph, Naima T. MD, MPH. Measles in Pregnancy: Clinical Considerations and Challenges. Obstetrics & Gynecology ():10.1097/AOG.0000000000006126, November 14, 2025. | DOI: 10.1097/AOG.0000000000006126

BUFFALO, NY – November 17, 2025 – A new #research perspective was #published in Oncotarget (Volume 16) on November 14, 2025, titled “A personal perspective of patient-centred clinical trials.” In this perspective, led by corresponding author Jia Liu of The Kinghorn Cancer Centre, St Vincent's Hospital, the University of New South Wales, and the Garvan Institute of Medical Research, three early-phase clinical trial participants — Trevor Tyne, Elizabeth Ivimey, and Leanne Duggan — reflect on their personal experiences with experimental cancer treatments. Their stories offer a unique perspective on the patient journey through early-phase trials and emphasize the need to design clinical research that prioritizes patients' needs, dignity, and lived realities. The authors highlight both the life-changing opportunities that trials can provide and the systemic barriers that still prevent many patients from participating. This perspective captures a turning point in how early-phase trials are viewed. Once considered a last resort, these trials are now increasingly offered earlier in treatment, especially with the rise of biomarker-guided therapies. In this context, the patient experience has become critical. The authors outline key benefits of participation, including access to novel therapies, ongoing medical monitoring, emotional support, and a strong sense of purpose in contributing to future medical advancements. However, they also point out significant challenges, such as restrictive eligibility criteria, high financial and logistical burdens, and communication gaps between patients and trial staff. “While no trial guarantees success, the level of support, access to innovative therapies, and sense of contribution to medical progress can be profoundly meaningful.” Each narrative provides insight into the clinical trial experience. One patient explains how living with a visual impairment required tailored accessibility support throughout the trial process Another shares how genomic testing led to targeted treatment after standard options failed. Despite their different diagnoses and circumstances, all three stories reflect resilience, hope, and a shared call for trial designs that better reflect the realities of diverse patients. To address these issues, the authors propose a number of improvements to trial design and delivery. These include expanding eligibility criteria, offering financial and logistical assistance, improving communication training for research staff, and introducing dedicated trial navigators to help guide patients through complex processes. They also focus on the importance of involving patient advocates in trial design and ensuring smoother transitions for patients moving between treatment centers. While early-phase trials focus on safety and effectiveness, the authors argue they must also be guided by core values like ethics and patient empowerment. This perspective serves as a reminder that the future of cancer research depends not only on scientific innovation, but on an honest partnership between patients and the research community. By sharing these real-world experiences, the article encourages a broader conversation about how to make clinical trials more responsive to the people they are designed to serve. DOI - https://doi.org/10.18632/oncotarget.28776 Correspondence to - Jia Liu - jia.liu@svha.org.au Abstract video - https://www.youtube.com/watch?v=2CCGN78n8ug To learn more about Oncotarget, visit https://www.oncotarget.com: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

It's World AMR Awareness Week (WAAW) and we have prepared a special episode in light of that. In this week's Communicable, Navaneeth Narayanan and Thomas Tängdén host Aula Abbara (London, UK), Guido Granata (Rome, Italy) and Tuomas Aro (Helsinki, Finland) to discuss the phenomenon of AMR in conflict and crisis zones. They elaborate on how difficult conditions and austere environments amplify the spread of AMR, drawing on findings from the ongoing conflicts in Ukraine, Gaza, Syria and other regions. Other topics covered include adapting antimicrobial stewardship and infection prevention and control (IPC) practices as well as the need for genuine political will and international collaboration to end conflicts and their exacerbation on AMR.This episode follows the webinar “Beyond the frontlines” organised by ESCMID's AMR Action Subcommittee for WAAW 2025, featuring the same guests, and is available on ESCMID Media. This Communicable episode was peer reviewed by Arjana Zerja of Mother Theresa University Hospital Centre, Tirana, Albania.  Related ESCMID and Communicable mediaESCMID Media, Part 1: Beyond the frontlines - tackling AMR in conflict and crisis zones, webinar Communicable episode 11: Nightmare series, part 2 – how to deal with carbapenemase producers Communicable episode 16: Climate change and infections – effects on clinical practice & sustainabilityResourcesTrainee Association of ESCIMD (TAE) Doctors without Borders (Médecins sans Frontières), Antibiogo, https://www.antibiogo.org/Doctors without Borders (Médecins sans Frontières), Mini-lab, https://fondation.msf.fr/en/projects/mini-lab Further ReadingAbbara A, et al. Unravelling the linkages between conflict and antimicrobial resistance. NPJ Antimicrob Resist. 2025. DOI: 10.1038/s44259-025-00099-yAbbara A, et al. A summary and appraisal of existing evidence of antimicrobial resistance in the Syrian conflict. Int J Infect Dis. 2018. DOI: 10.1016/j.ijid.2018.06.010Abu-Shomar R, et al. Multidrug-resistant Pseudomonas isolated from water at primary health care centers in Gaza, Palestine: a cross-sectional study. IJID Reg. 2025. DOI: 10.1016/j.ijregi.2025.100671Aldbis A, et al. The lived experience of patients with conflict associated injuries whose wounds are affected by antimicrobial resistant organisms: a qualitative study from northwest Syria. Confl Health. 2023. DOI: 10.1186/s13031-023-00501-4Aro T, et al. War on antimicrobial resistance: high carriage rates of multidrug-resistant bacteria among war-injured Ukrainian refugees. Clin Microbiol Infect. 2025. DOI: 10.1016/j.cmi.2025.07.010  Bazzi W, et al. Heavy Metal Toxicity in Armed Conflicts Potentiates AMR in A. baumannii by Selecting for Antibiotic and Heavy Metal Co-resistance Mechanisms. Front Microbiol. 2020. DOI: 10.3389/fmicb.2020.00068 Dewachi O. War Biology and Antimicrobial Resistance: The Case of Gaza, AMR Insights, 2024.Granata G, et al. The impact of armed conflict on the development and global spread of antibiotic resistance: a systematic review. Clin Microbiol Infect. 2024. DOI: 10.1016/j.cmi.2024.03.029 Huang XZ, et al. Molecular analysis of imipenem-resistant Acinetobacter baumannii isolated from US service members wounded in Iraq, 2003-2008. Epidemiol Infect. 2012. DOI: 10.1017/S0950268811002871Hujer KM, et al. Analysis of antibiotic resistance genes in multidrug-resistant Acinetobacter sp. isolates from military and civilian patients treated at the Walter Reed Army Medical Center. Antimicrob Agents Chemother. 2006. DOI: 10.1128/AAC.00778-06Karah N, et al. Teleclinical Microbiology: An Innovative Approach to Providing Web-Enabled Diagnostic Laboratory Services in Syria. Am J Clin Pathol. 2022. DOI: 10.1093/ajcp/aqab160Keen EF 3rd, et al. Evaluation of potential environmental contamination sources for the presence of multidrug-resistant bacteria linked to wound infections in combat casualties. Infect Control Hosp Epidemiol. 2012. DOI: 10.1086/667382Murray CK, et al. Recovery of multidrug-resistant bacteria from combat personnel evacuated from Iraq and Afghanistan at a single military treatment facility. Mil Med. 2009. DOI: 10.7205/milmed-d-03-8008Petersen K, et al. Diversity and clinical impact of Acinetobacter baumannii colonization and infection at a military medical center. J Clin Microbiol. 2011. DOI: 10.1128/JCM.00766-10Scott P, et al. An outbreak of multidrug-resistant Acinetobacter baumannii-calcoaceticus complex infection in the US military health care system associated with military operations in Iraq. Clin Infect Dis. 2007. DOI: 10.1086/518170Sensenig RA, et al. Longitudinal characterization of Acinetobacter baumannii-calcoaceticus complex, Klebsiella pneumoniae, and methicillin-resistant Staphylococcus aureus colonizing and infecting combat casualties. Am J Infect Control. 2012. DOI: 10.1016/j.ajic.2011.03.025World Health Organization. Fourth WHO Global Evidence Review on Health and Migration stresses that equitable access to and appropriate use of antibiotics for refugees and migrants is essential to tackling Antimicrobial Resistance, News, 2022.

Diese Vorlesung bietet eine umfassende Einführung in die aktuellen Entwicklungen der Konstruktionsgrammatik, eine der zentralen Theorien der kognitiven Linguistik. Im Mittelpunkt steht die Annahme, dass Sprache aus „Konstruktionen“ besteht – konventionalisierten Paarungen von Bedeutung und Form. Die Vorlesung wird durch zwei Schwerpunktsetzungen gekennzeichnet sein. Zum einen ist das die enge Verbindung der Konstruktionsgrammatik mit der Framesemantik. Die Framesemantik kann konstruktionelle Analysen ideal ergänzen, indem sie die konzeptuellen Grundlagen sprachlicher Bedeutung detailliert erschließt. Wir untersuchen, wie Konstruktionen und Frames, Wissensrahmen, in Relation zueinander stehen. Zum anderen widmet sich die Vorlesung der Konstruktikographie. Dieses Gebiet verbindet die theoretischen Erkenntnisse der Konstruktionsgrammatik mit den Methoden der praktischen Lexikographie, um „Konstruktika“ – umfassende Verzeichnisse von Konstruktionen – zu beschreiben. Wir werden Ziele und Methoden der Konstruktikographie erörtern, einschließlich korpusbasierter Workflows, Annotationspraktiken und der Strukturierung von Konstruktionsbeschreibungen.Präsentation (*.pdf): Alexander Lasch. 2025. Konstruktionsgrammatik. Zenodo. DOI: https://doi.org/10.5281/zenodo.17370032. Videoaufzeichnungen: ⁠⁠⁠⁠⁠⁠⁠https://youtube.com/@AlexanderLasch⁠⁠⁠⁠⁠⁠⁠. Informationen & Material zu allen Vorlesungen: ⁠⁠⁠⁠⁠⁠⁠https://kurzelinks.de/fl7f⁠⁠⁠⁠⁠⁠⁠. Worksheet zu den Vorlesungen: ⁠https://kurzlinks.de/WorksheetVorlesungen⁠. Intro: "Reflections" von Scott Holmes (CC BY via ⁠⁠⁠⁠⁠⁠FMA⁠⁠⁠⁠⁠⁠).#Linguistik #OER #Sprache #Sprachwissenschaft #Grammatik #Konstruktionsgrammatik

What is the main driver of sex differences in heart failure with reduced ejection fraction (HFrEF)? In our latest episode, Associate Editor Dr. Petra Kleinbongard (University of Duisburg-Essen) interviews lead author Dr. Matthieu Ruiz (Montreal Heart Institute) and expert Dr. Catherine Mounier (Université du Québec à Montréal) about the new study by David et al. that explores sex-specific effects of B-vitamin supplementation on heart failure with reduced ejection fraction in mice subjected to pressure overload. The research by Ruiz and co-authors found that B-vitamins improved survival rates, cardiac function, and reduced fibrosis in female mice. However, male mice exhibited persistent inflammation, fibrosis, and unfavorable lipidome remodeling despite the B-vitamin supplementation. The findings underscore the sex-specific benefits of B-vitamins in heart failure, and confirm the importance of animal models of human disease for clinical translation. Listen now and learn more.   Chloé David, Sonia Deschênes, Gabriel Ichkhan, Caroline Daneault, Isabelle Robillard Frayne, Bertrand Bouchard, Anik Forest, Yan Fen Shi, Marie-Ève Higgins, Martin G. Sirois, Jean-Claude Tardif, Mathias Mericskay, Jérôme Piquereau, and Matthieu Ruiz Sex-Specific Modulation of Cardiac Fibrosis and Lipid Metabolism by B-Vitamins in Heart Failure with Reduced Ejection Fraction in Mice Am J Physiol Heart Circ Physiol, published June 12, 2025. DOI: 10.1152/ajpheart.00841.2024

Mapping the Landscape of Technical Standards: A Nationwide Review of Medical Schools Interviewees: Carol Haywood, PhD, OTR/L — Assistant Professor, Medical Social Sciences, Northwestern University Feinberg School of Medicine Chris Moreland, MD, MPH — Professor of Internal Medicine; Division Chief for Hospital Medicine; Interim Associate Chair for Faculty Affairs and Development, Dell Medical School (Comments made in ASL and voiced through interpreters) Interviewer: Lisa Meeks, PhD, MA — Guest Editor, Academic Medicine Supplement on Disability Inclusion in Undergraduate Medical Education Description: In this episode of Stories Behind the Science, we sit down with Dr. Carol Haywood and Dr. Chris Moreland to explore a deceptively powerful document: the medical school technical standards. These quietly influential statements—often tucked deep in an admissions webpage—shape who feels welcome to apply, who gains access, and how institutions imagine the future of their profession. Haywood and Moreland, co-authors of a national analysis featured in the Academic Medicine supplement on Disability Inclusion in Undergraduate Medical Education, unpack what happens when ambiguous language, outdated assumptions, and vague expectations collide with real people making real decisions about their careers. Together, they dig into the nuances of functional vs. organic standards, the importance of clarity for applicants who lack insider knowledge, and the ripple effects of inequitable policies across a learner's entire training experience. What emerges is both sobering and hopeful: a field undergoing change, a growing recognition that words matter, and a roadmap for institutions ready to bring their values into alignment with their practices. The discussion reviews: How technical standards became a gatekeeper—and why revising a single sentence can shift an entire culture. Why students with disabilities read these documents differently—and why that matters for equity. How ambiguity in admissions can deter talented future physicians long before they step foot in a classroom. What schools can do now to create standards that prioritize competence, flexibility, and inclusion. Dr. Haywood brings a researcher's lens and an occupational therapist's creativity to the conversation, illuminating how functional expectations—not assumptions about bodies—should guide medical training. Dr. Moreland shares deeply personal reflections on navigating technical standards as a deaf physician, offering rare insight into how these documents land on applicants with lived experience. This episode invites the audience to imagine a medical education landscape where technical standards do what they should do—define competence, set expectations, and open doors—rather than unintentionally closing them. Bios:  Carol Haywood, PhD, OTR/L, is Assistant Professor of Medical Social Sciences in the Determinants of Health Division and core faculty in the Center for Health Services and Outcomes Research at Northwestern University Feinberg School of Medicine in Chicago, IL. Building from her work as an occupational therapist in acute rehabilitation, she completed a PhD in occupational science at the University of Southern California and a postdoctoral fellowship in health services and outcomes research at Northwestern University. Using qualitative, mixed methods, and community-engaged research approaches, she studies disability in a variety of contexts, as well as health care access, coordination, and quality. She is driven by a vision of health care that facilitates equity for people with disabilities. Chris Moreland, MD MPH, is a professor of medicine, interim associate department chair for faculty affairs, and division chief for hospital medicine at Dell Medical School at UT Austin. He practices clinically as a hospitalist. As a career-long clinician educator, his teaching has been recognized regionally and nationally. His collaborative advocacy and research efforts describe the experiences of our healthcare workforce and learners with disabilities, as well as strategies to foster pathways to thriving clinicians. He has served as president and longtime board member for the Association of Medical Professionals with Hearing Losses; he holds current roles on the Docs with Disabilities Initiative advisory board, the AAMC Group on Diversity and Inclusion steering committee, and as a consultant with the National Deaf Center. Transcript: https://docs.google.com/document/d/18hUPguWf_jWeDC1fmOgSKSXPv4xGnkQIPUi3zhfH540/edit?usp=sharing Resources: Singer, Tracey; Madanguit, Lance MD; Fok, King T. MD, MSc; Stauffer, Catherine E. MD; Meeks, Lisa M. PhD, MA; Moreland, Christopher J. MD, MPH; Huang, Lynn MS; Case, Benjamin MPH; Lagu, Tara MD, MPH; Kannam, Allison MD; Haywood, Carol PhD, OTR/L. Mapping the Landscape of Technical Standards: A Nationwide Review of Medical Schools. Academic Medicine 100(10S):p S144-S151, October 2025. | DOI: 10.1097/ACM.0000000000006135   McKee, M.M., Gay, S., Ailey, S., Meeks, L.M. (2020). Technical Standards. In: Meeks, L., Neal-Boylan, L. (eds) Disability as Diversity. Springer, Cham. https://doi.org/10.1007/978-3-030-46187-4_9 Equal Access for Students with Disabilities: The Guide for Health Science and Professional Education (2nd Ed). Meeks LM, Jain NR, & Laird EP. Springer Publishing, 2020. Key Words: Disability inclusion · Technical standards · Medical education · Admissions · Accessibility · Equity · Policy reform

BUFFALO, NY — November 13, 2025 — A new #research paper was #published in Volume 17, Issue 10 of Aging-US on October 3, 2025, titled “The role of phenylalanine and tyrosine in longevity: a cohort and Mendelian randomization study.” In this study led by Jie V. Zhao, Yitang Sun, Junmeng Zhang, and Kaixiong Ye from the University of Hong Kong and the University of Georgia, researchers investigated whether two amino acids, phenylalanine and tyrosine, affect how long people live (lifespan). The results suggest that higher levels of tyrosine are linked to shorter life expectancy in men, pointing to potential sex-specific approaches to promoting longevity. Phenylalanine and tyrosine are amino acids involved in metabolism and brain function. Both are found in protein-rich foods and dietary supplements, but their long-term effects on aging are not well understood. Tyrosine, in particular, is a building block of neurotransmitters such as dopamine, which regulate mood and cognitive function, making it a molecule of interest in aging research. The study analyzed data from more than 270,000 individuals in the UK Biobank. Using both observational and genetic methods, the researchers examined the associations between blood levels of phenylalanine and tyrosine with overall mortality and predicted lifespan. Although both amino acids were initially linked to higher mortality risk, only tyrosine showed a consistent and potentially causal association with reduced life expectancy in men. Genetic analyses estimated that elevated tyrosine levels could shorten men's lifespan by nearly one year. No significant effect was observed in women. These findings remained consistent even after adjusting for related factors, including the role of phenylalanine. This suggests that tyrosine may independently influence aging. The researchers also observed that men tend to have higher tyrosine levels than women, which could partly explain the gender gap in lifespan. “Phenylalanine showed no association with lifespan in either men or women after controlling for tyrosine.” The exact mechanisms behind this effect are still under investigation. However, tyrosine's involvement in insulin resistance and the production of stress-related neurotransmitters may be contributing factors. Insulin resistance is associated with many age-related diseases, and hormone-related pathways influenced by tyrosine may differ between men and women, potentially explaining the sex-specific outcomes. Although tyrosine is commonly marketed as a supplement for enhancing focus and mental performance, the study raises concerns about its long-term impact on lifespan. While the researchers did not directly study tyrosine supplementation, their findings suggest that people with high tyrosine levels may benefit from dietary adjustments. Strategies such as protein restriction could help reduce tyrosine levels and support healthier aging. Further studies are needed to confirm these findings and explore whether diet and lifestyle changes can safely lower tyrosine levels to promote longevity. DOI - https://doi.org/10.18632/aging.206326 Corresponding author - Jie V. Zhao - janezhao@hku.hk Abstract video - https://www.youtube.com/watch?v=rr0G44TD36M Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@Aging-US LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Well, from time to time we cover RANDOM tidbits of information which cover RANDOM questions and/or RANDOM patient care issues that we encounter. In this episode we will cover one OB issue related to recurrent pregnancy loss, one GYN issue related to unilateral breast swelling in a patient with SLE, and one RANDOM life perspective response from a mock interview that I participated in for a residency candidate. Listen in fordetails!1.     Viviana DO; Giugni, Claudio Schenone MD; Ros, Stephanie T. MD, MSCI. Factor V and recurrent pregnancy loss: de Assis, Evaluation of Recurrent Pregnancy Loss. Obstetrics & Gynecology 143(5):p 645-659, May 2024. | DOI: 10.1097/AOG.0000000000005498Unilateral Breast Swelling with SLE: 2.     Voizard B, Lalonde L, Sanchez LM, et al. LupusMastitis as a First Manifestation of Systemic Disease: About Two Cases With a Review of the Literature. European Journal of Radiology. 2017;92:124-131. doi:10.1016/j.ejrad.2017.04.023.3.     Kinonen C, Gattuso P, Reddy VB. Lupus Mastitis:An Uncommon Complication of Systemic or Discoid Lupus. The American Journal of Surgical Pathology. 2010;34(6):901-6. doi:10.1097/PAS.0b013e3181da00fb.4.      Summers TA, Lehman MB, Barner R, Royer MC. Lupus Mastitis: A Clinicopathologic Review and Addition of a Case. Advances in Anatomic Pathology.2009;16(1):56-61. doi:10.1097/PAP.0b013e3181915ff7.5.     Jiménez-Antón A, Jiménez-Gallo D,Millán-Cayetano JF, Navarro-Navarro I, Linares-Barrios M. Unilateral Lupus Mastitis.Lupus. 2023;32(3):438-440. doi:10.1177/09612033221151011.STRONG COFFEE PROMO: 20% Off Strong Coffee Company https://strongcoffeecompany.com/discount/CHAPANOSPINOBG

BUFFALO, NY - November 12, 2025 – A new #research paper was #published in Oncotarget (Volume 16) on November 6, 2025, titled “LRIG1-3 in gliomas: LRIG1 protein expression decreased in higher grade gliomas.” In this study by Marlene Happe, Saskia Kuhl, Lukas Görtz, Roland Goldbrunner and Marco Timmer, from the University of Cologne, researchers found that the LRIG1 protein, which may help suppress tumors, is present at lower levels in more aggressive gliomas, a type of brain tumor. The findings suggest that LRIG1 could serve as a useful marker for tumor severity and potentially as a target for future therapies. Gliomas are the most common malignant brain tumors in adults and carry a poor prognosis, particularly in their most severe form, glioblastoma. This study investigated three related proteins: LRIG1, LRIG2, and LRIG3, which are involved in regulating cell growth signals. While LRIG1 and LRIG3 have shown tumor-suppressing effects in previous studies, LRIG2 is thought to support tumor growth. The researchers analyzed tumor samples from patients to understand how these proteins behave across different glioma grades and how they respond to chemotherapy. The results showed that LRIG1 protein levels decline significantly as tumor grade increases. Low-grade gliomas displayed much higher LRIG1 expression than high-grade tumors. Among high-grade tumors, primary glioblastomas had the lowest levels of LRIG1. Interestingly, secondary glioblastomas, which typically develop from lower-grade tumors, had higher levels of LRIG1 than primary glioblastomas. This difference may contribute to their relatively better clinical outcomes. These results highlight LRIG1's potential role in slowing tumor progression. In contrast, LRIG2 showed a more complex pattern. While its gene expression was higher in lower-grade tumors, the actual protein levels were slightly elevated in higher-grade ones, which are more aggressive. This mismatch suggests that processes occurring after gene transcription may influence how much LRIG2 protein is produced. “However, our data on LRIG2 indicate that its role in glioma may be more complex than previously thought, warranting further investigation.” Concerning LRIG3, it was found in higher amounts in glioma tissue compared to surrounding healthy tissue. Its expression was particularly high in low-grade tumors. However, chemotherapy did not consistently affect LRIG3 levels, and results varied depending on tumor type and treatment status. Overall, the study suggests that members of the LRIG protein family, especially LRIG1, could serve as important biomarkers to distinguish between glioma types and grades. Although chemotherapy did not significantly change their expression in most cases, these proteins have high potential as diagnostic tools or therapeutic targets. Further research is needed to better understand their roles in glioma development and treatment response. DOI - https://doi.org/10.18632/oncotarget.28775 Correspondence to - Marco Timmer - marco.timmer@uk-koeln.de Abstract video - https://www.youtube.com/watch?v=ZHsKLBEyBbM Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28775 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, oncology, glioma, glioblastoma, LRIG1, LRIG2, LRIG3 To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Send us a textA classroom can be a launchpad for climate action when reading meets real life. We sit down with Miami-area educator Catherine Manfra to explore how English language arts becomes a powerful space for climate literacy, creative expression, and student agency—especially in a region living with hurricanes, sea-level rise, and rapid development at the edge of the Everglades.Catherine walks us through her Earth Day unit anchored by Hope Jahren's The Story of More and climate-focused poetry, showing how accessible science writing invites teens into complex topics without overwhelming them. From lunchroom showcases to one-minute PSAs, her students translate facts into story, practice tight writing and media literacy, and share concrete steps that counter defeatism. We also unpack how giving students information and choice sparks deeper research, community involvement, and everyday action.Beyond the classroom, we highlight the Stories-To-Live-By collective, a statewide network of teachers and researchers crafting place-based, multimodal approaches to climate education while navigating book bans and shifting policies. Catherine shares how the group's workshops and shared resources build confidence. She also talks about how the Fairchild Challenge debate strengthens ELA standards, STEM integration, and civic discourse by asking students to argue multiple sides of timely environmental issues. It's a hopeful blueprint for educators who want rigorous, inclusive climate literacies that prepare young people for a just, livable future.If this conversation resonates, follow the show, share it with a colleague, and leave a review with your favorite climate literacy text or project idea. Your feedback helps us bring more teacher-tested practices to more classrooms.Catherine is a Florida native. Born in Hialeah, a suburb of Miami with a predominantly Hispanic community, she now lives in the Kendall area just south of Miami. She has seen Miami-Dade County continue to expand westward since her childhood, including encroachment on the Florida Everglades. The Florida Everglades are ecologically significant in their role as a subtropical wilderness, a habitat for many threatened and endangered species, and a provider of flood control, water filtration, and freshwater supply for millions of people. She became a part of the Stories-To-Live-By project by answering an initial online survey of teachers who incorporate environmental topics into their curriculum. After teaching all levels of high school English in public schools in Miami-Dade County for 22 years, Catherine now teaches at Palmer Trinity School, an independent private school. Additionally, Catherine is a part of the Junior League of Miami, a women's group that serves and focuses on women's and children's issues in the community from education to safety. To cite this episode: Persohn, L. (Host). (2025, Oct 14). A Stories-To-Live-By Conversation with Catherine Manfra. (Season 6, No. 4) [Audio podcast episode]. In Classroom Caffeine Podcast series. https://www.classroomcaffeine.com/guests. DOI: 10.5240/33A8-951D-21CD-B5CE-9F8A-BConnect with Classroom Caffeine at www.classroomcaffeine.com or on Instagram, Facebook, Twitter, and LinkedIn.

This week we're traveling back to 18th-century France with Perfume: The Story of a Murderer! Join us as we learn about tanneries, the town of Grasse, infanticide, perfumers' guilds, and more! Sources: https://www.rogerebert.com/reviews/perfume-the-story-of-a-murderer-2007 https://www.rottentomatoes.com/m/perfume_the_story_of_a_murderer https://en.wikipedia.org/wiki/Perfume:_The_Story_of_a_Murderer_%28film%29 A.O. Scott, https://www.nytimes.com/2006/12/27/movies/27perf.html  Tracey Rizzo (2004) Between dishonor and death: infanticides in the causes célèbres of eighteenth-century France, Women's History Review, 13:1, 5-22, DOI: 10.1080/09612020400200380 Arhoune, Ilham@, Impact of Chemicals and Working Conditions on Tannery Workers' Health and Recommendations for Improving the Situation. Available at SSRN: https://ssrn.com/abstract=5347318 or http://dx.doi.org/10.2139/ssrn.5347318 "     1. Rabbani G, Billah B, Giri A, et al. Factors Associated With Health Complaints Among Leather Tannery Workers in Bangladesh. Workplace Health & Safety. 2020;69(1):22-31. doi:10.1177/2165079920936222   " https://montecristomagazine.com/beauty/medieval-tannery-town-french-riviera-became-perfume-capital-world#gsc.tab=0 https://www.tfcg.ca/old-occupation-tanner Kirsten James, The Science of Scent and Business of Perfume in Paris and London, 1650-1815, PhD thesis, University of Toronto (2019).  Eleanor Beardsley, "Sick Of Tanneries' Stench Centuries Ago, A French Town Began Making Perfume. It Stuck." NPR, available at https://www.npr.org/2021/09/21/1039393853/sick-of-tanneries-stench-centuries-ago-a-french-town-began-making-perfume-it-stu Luxus Magazine, Grasse: World Capital of Perfume: https://magazine.luxus-plus.com/en/brief-history-of-luxury-grasse-world-capital-of-perfume/

BUFFALO, NY — November 11, 2025 — A new #research paper was #published in Volume 17, Issue 10 of Aging-US on October 1, 2025, titled “L-β-aminoisobutyric acid (L-BAIBA) in combination with voluntary wheel running exercise enhances musculoskeletal properties in middle-age male mice.” In this study led by first author Julian A. Vallejo and corresponding author Michael J. Wacker from the University of Missouri, Kansas City, researchers investigated how L-β-aminoisobutyric acid (L-BAIBA), a natural compound released during exercise, works together with regular physical activity to improve muscle and bone health in middle-aged male mice. The findings may support new strategies to maintain musculoskeletal health in aging populations, especially those at risk for mobility loss or osteoporosis. Muscle and bone strength naturally decline with age, increasing the risk of falls, fractures, and reduced quality of life. While exercise remains the most effective way to counteract this deterioration, it is often difficult for older individuals to maintain sufficient activity levels to see results. L-BAIBA, a molecule naturally produced during physical activity, is known to promote energy metabolism and support muscle and bone cells. This study explored its potential to work in synergy with endurance exercise to maximize health benefits in aging bodies. Researchers studied 12-month-old male mice that were split into different groups. Some remained sedentary, while others exercised freely on running wheels. Half of each group received daily L-BAIBA supplementation. After three months, the mice that received both the supplement and exercise showed greater improvements than those receiving either one alone. The soleus, a slow-twitch muscle essential for endurance and balance, grew larger and stronger only in the combined treatment group. These muscles also shifted to a more fatigue-resistant fiber type and had a larger number of oxidative fibers. “To investigate this hypothesis, we subjected 12-month-old (as a model of middle-age) male C57BL6 mice to voluntary wheel running (VWR) with L-BAIBA (100mg/kg/day) (VWR+L-BAIBA), VWR alone, L-BAIBA alone, or none (CTRL) for three months.” The study also showed significant improvements in bone health. Mice that received both exercise and L-BAIBA developed thicker and denser trabecular bone, along with reduced fat levels in the bone marrow, indicators of stronger, healthier bones. These changes were not observed in the groups that only exercised or only received L-BAIBA. Although the compound caused minor changes in heart electrical activity, it did not affect heart size or overall function, suggesting it is safe in this setting. These findings suggest that L-BAIBA may enhance the benefits of physical activity by supporting muscle strength and bone structure, particularly in slow-twitch muscle fibers. This combination could serve as a therapeutic strategy to help older adults, including those unable to engage in regular exercise, maintain musculoskeletal health. As the aging population grows, there is a growing need for solutions that support muscle and bone health without requiring strenuous activity. This research highlights the potential of natural, exercise-related molecules like L-BAIBA to help maintain mobility and strength throughout aging. DOI - https://doi.org/10.18632/aging.206325 Corresponding author - Michael J. Wacker — wackerm@umkc.edu Abstract video - https://www.youtube.com/watch?v=A-zfrLUikfQ Visit https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@Aging-US LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY - November 10, 2025 – A new #research paper was #published in Oncotarget (Volume 16) on November 6, 2025, titled “Anti-DNA virus agent cidofovir - loaded green synthesized cerium oxide nanoparticles (Nanoceria): Nucleic acids (DNA and RNA) binding affinity and cytotoxicity effects.” In this study, led by Nahid Shahabadi from Razi University in Kermanshah, researchers developed an environmentally friendly approach to enhance the performance of cidofovir, a drug used to treat infections caused by DNA viruses. The work responds to the growing need for therapies that are safer, more effective, and better targeted. The research team developed a new compound by loading cidofovir onto green-synthesized cerium oxide nanoparticles (nanoceria), known as CDV-CeO2 NPs. This method combines the drug's antiviral and anticancer properties with the biological activity of nanoceria, which is known for its antioxidant, anti-inflammatory, and tumor-targeting effects. To avoid toxic chemicals, the nanoparticles were synthesized using quince fruit peel extract, making the process more sustainable and suitable for medical applications. Laboratory experiments showed that the CDV-CeO2 nanoparticles were significantly more effective at killing breast cancer cells than either cidofovir or cerium oxide nanoparticles alone. At the highest tested concentration, the new compound destroyed more than 97% of cancer cells, compared to 72% with cidofovir alone and 50% with nanoparticles alone. These findings suggest that the combined formulation enhances anticancer activity and may allow for lower drug doses with fewer side effects. To understand how these nanoparticles interact with genetic material, the team studied their binding to DNA and RNA, two key molecules involved in cancer development and viral replication. CDV-CeO2 nanoparticles showed strong binding affinity through two mechanisms: groove binding, which fits into natural curves of the genetic molecule strands, and intercalation, which inserts between base pairs. The nanoparticles formed stable complexes that responded to temperature, indicating reliable interactions in biological systems. “The novelty of this work lies in the innovative green synthesis method, the dual-functional therapeutic application, and the enhanced biological activity of the CDV-CeO2 NPs, which collectively position these nanoparticles as promising candidates for future cancer and antiviral therapies.” This research presents a potential new strategy for improving drug targeting and delivery using green nanotechnology. The approach could lead to more effective treatments for diseases such as breast cancer and infections caused by human papillomavirus (HPV) and other DNA viruses. However, further research, including animal and clinical studies, is needed to confirm the safety and long-term effectiveness of this treatment. Overall, this study represents a significant step toward combining natural materials with nanomedicine to create more efficient therapies. If supported by future research, CDV-CeO2 nanoparticles could offer a new generation of dual-action treatments. DOI - https://doi.org/10.18632/oncotarget.28774 Correspondence to - Nahid Shahabadi - nahidshahabadi@yahoo.com Abstract video - https://www.youtube.com/watch?v=Il9CsfgO2mU Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us on social media: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

In this essay, Steve Emery and Dai O'Brien discuss the life and politics of a deaf anarchist communist, Leonard A. Motler. Steve and Dai explain his significance to both the anarchist movement in the UK as a visibly deaf signing person and to the deaf community as an openly anarchist radical. A longer version of this article appeared in Anarchist Studies 33:1 (2025). This episode is read by Isobel van Hagen. Steve Emery is a freelance writer and researcher in the field of Deaf Studies and works as a project manager at the University of Surrey. His most recent publications are: O'Brien, D. and Emery, S. (2025). L.A. Motler: a Deaf Anarchist. Anarchist Studies 33(1) DOI:10.3898/AS.33.1.02X and Emery, S. D., and Iyer, S. (2024). Deaf Migrants in London in Kusters, AMJ, Moriarty, E, le Maire, A, Iyer, S & Emery, S (2024). Deaf Mobility Studies: Exploring International Networks, Tourism, and Migration. Washington DC: Gallaudet University Press, 91-117. DOI:10.1111/jola.70013. Dai O'Brien is an Associate Professor in BSL and Deaf Studies at York St John University. His most recent publications are: Sauntson, H., Cunningham, C., Ennser-Kananen, J., & O'Brien, D. (2025). Language and Social Justice: An Introduction to Linguistic Activism. Routledge. and O'Brien, D. and Emery, S. (2025). L.A. Motler: a Deaf Anarchist. Anarchist Studies 33(1) DOI:10.3898/AS.33.1.02 Isobel van Hagen is a PhD candidate in politics and philosophy at Loughborough University. 

Mindfulness Training and Stress Reactivity in Substance Abuse: Results from a Randomized, Controlled Stage I Pilot StudyIn this episode, Dr. Jud delves into groundbreaking research comparing mindfulness training (MT) and cognitive behavioral therapy (CBT) for individuals with substance use disorders. This pilot study investigates the role of mindfulness in managing stress and addiction, highlighting its potential to reduce psychological and physiological stress responses. Learn how MT could become a viable treatment option alongside traditional therapies, the challenges faced during the study, and what these findings mean for the future of addiction treatment.Reference: Brewer, J. A., Sinha, R., Chen, J. A., Michalsen, R. N., Babuscio, T. A., Nich, C., ... & Rounsaville, B. J. (2009). Mindfulness Training and Stress Reactivity in Substance Abuse: Results from a Randomized, Controlled Stage I Pilot Study. Substance Abuse, 30(4), 306-317. DOI: 10.1080/08897070903250241Let's connect on Instagram

Diese Vorlesung bietet eine umfassende Einführung in die aktuellen Entwicklungen der Konstruktionsgrammatik, eine der zentralen Theorien der kognitiven Linguistik. Im Mittelpunkt steht die Annahme, dass Sprache aus „Konstruktionen“ besteht – konventionalisierten Paarungen von Bedeutung und Form. Die Vorlesung wird durch zwei Schwerpunktsetzungen gekennzeichnet sein. Zum einen ist das die enge Verbindung der Konstruktionsgrammatik mit der Framesemantik. Die Framesemantik kann konstruktionelle Analysen ideal ergänzen, indem sie die konzeptuellen Grundlagen sprachlicher Bedeutung detailliert erschließt. Wir untersuchen, wie Konstruktionen und Frames, Wissensrahmen, in Relation zueinander stehen. Zum anderen widmet sich die Vorlesung der Konstruktikographie. Dieses Gebiet verbindet die theoretischen Erkenntnisse der Konstruktionsgrammatik mit den Methoden der praktischen Lexikographie, um „Konstruktika“ – umfassende Verzeichnisse von Konstruktionen – zu beschreiben. Wir werden Ziele und Methoden der Konstruktikographie erörtern, einschließlich korpusbasierter Workflows, Annotationspraktiken und der Strukturierung von Konstruktionsbeschreibungen.Präsentation (*.pdf): Alexander Lasch. 2025. Konstruktionsgrammatik. Zenodo. DOI: https://doi.org/10.5281/zenodo.17370032. Videoaufzeichnungen: ⁠⁠⁠⁠⁠⁠⁠https://youtube.com/@AlexanderLasch⁠⁠⁠⁠⁠⁠⁠. Informationen & Material zu allen Vorlesungen: ⁠⁠⁠⁠⁠⁠⁠https://kurzelinks.de/fl7f⁠⁠⁠⁠⁠⁠⁠. Worksheet zu den Vorlesungen: ⁠https://kurzlinks.de/WorksheetVorlesungen⁠. Intro: "Reflections" von Scott Holmes (CC BY via ⁠⁠⁠⁠⁠⁠FMA⁠⁠⁠⁠⁠⁠).#Linguistik #OER #Sprache #Sprachwissenschaft #Grammatik #Konstruktionsgrammatik

This week we speak with Ohio State ACHD fellow Andrew Freddo MD, PhD about a recent large single center study he conducted assessing the cardiovascular drugs that adult Fontan patients are taking and whether they might offer us insights into general well-being. Are there agents that are associated with worse outcomes? If so, is this a situation of the agent causing harm or is it a possible marker of illness? Are there agents associated with improved outcomes? These are amongst the questions reviewed with Dr. Freddo this week. DOI: 10.1016/j.jacadv.2025.102070

Episode Overview In this episode, Dr. David Rosenblum discusses the role of supplements and complementary strategies in the management of chronic pain. Drawing from clinical practice at AABP Integrative Pain Care, as well as his teaching and training programs, Dr. Rosenblum reviews how nutraceuticals, regenerative therapies, ultrasound-guided procedures, and neuromodulation can work together to improve patient outcomes and reduce opioid reliance. This episode also highlights educational opportunities and exam-prep resources for pain fellows, residents, anesthesiologists, physiatrists, and APPs looking to expand their interventional pain, ultrasound, and regenerative medicine skill sets. Key Topics Discussed Evidence and clinical rationale for select supplements in chronic pain management The role of ultrasound guidance in improving accuracy and safety in interventional pain procedures How regenerative medicine techniques such as PRP and BMAC are shaping personalized pain care Practical considerations when combining supplements with neuromodulation, RFA, or injections Patient case applications and real-world treatment planning Educational Offerings & Learning Opportunities PainExam / NRAP Academy Training & Programs: Neuromodulation & Regional Anesthesia Workshops Ultrasound-Guided Pain Procedures Regenerative Pain Medicine Training Virtual Pain Fellowship Pain Management Board Review & Question Banks Learn More / Register: www.AABPpain.com

No episódio 93 do Fronteiras no Tempo, Marcelo Beraba e o Estagiário Rodolfo recebem dois convidados de peso para uma conversa que atravessa décadas de disputas políticas, econômicas e culturais: a professora Camila Feix Vidal (Economia e Relações Internacionais – UFSC) e o professor Marcos Sorrilha (História – UNESP). Juntos, eles exploram a Influência dos Estados Unidos na América Latina, analisando como o poder norte-americano moldou governos, economias, culturas e até imaginários sociais em nosso continente. Da Doutrina Monroe à Guerra Fria, das intervenções militares à dependência econômica, o episódio mergulha nas múltiplas camadas dessa relação complexa – marcada tanto por alianças estratégicas quanto por tensões profundas. Se você quer entender como o "quintal americano" se transformou em um campo de disputas globais e como essas dinâmicas ainda ecoam no presente, este episódio é indispensável. Dá o play e vem com a gente atravessar as fronteiras da história e da geopolítica! Artes do Episódio: C. A. Mencionado no Episódio YOUTUBE (Canal do Sorrilha). Qual é o correto: Americano ou estadunidense? YouTube, 2023. Disponível em: https://www.youtube.com/watch?v=KWKktKCj2Qc A IDADE DOURADA (The Gilded Age). Criação de Julian Fellowes. [Série de televisão]. Estados Unidos: HBO, 2022–. Disponível em: https://www.imdb.com/pt/title/tt4406178/ GREJO, Camila Bueno. Entre a diplomacia e a História: a atuação de Estanislao Zeballos frente ao Panamericanismo. Revista de Historia de América, n. 165, p. 165–191, maio-ago. 2023. ISSN impresso: 0034-8325. ISSN eletrônico: 2663-371X. DOI: https://doi.org/10.35424/rha.165.2023.1106 INSTITUTO DE ESTUDOS LATINO-AMERICANOS (IELA – UFSC). Página institucional. Florianópolis: Universidade Federal de Santa Catarina, [s.d.]. Disponível em: https://iela.ufsc.br/instituto/?ancora=#colaboradores . Acesso em: 4 nov. 2025. INSTITUTO DE ESTUDOS LATINO-AMERICANOS (IELA – UFSC). Canal no YouTube. Florianópolis: Universidade Federal de Santa Catarina, [s.d.]. Disponível em: https://www.youtube.com/@Ielaufsc . Acesso em: 4 nov. 2025. Financiamento Coletivo Existem duas formas de nos apoiar Pix recorrente – chave: fronteirasnotempo@gmail.com Apoia-se – https://apoia.se/fronteirasnotempo Redes Sociais Twitter, Facebook, Youtube, Instagram Contato fronteirasnotempo@gmail.com Material Complementar ANDREWS, George Reide. América Afro-Latina (1800-2000). trad. Magda Lopes. São Carlos: EDUFSCAR, 2007 DULCI, Tereza Maria Spyer. As conferências Pan-Americanas (1889 a 1928): identidades, união aduaneira e arbitragem. São Paulo: Alameda Casa Editorial, 2013. FITZ, Caitlin Annette. Our Sister Republics: The United States in an Age of American Revolutions. New York: W.W. Norton & Company, 2016. PECEQUILO, Cristina Soreanu. A política externa dos Estados Unidos. 3. ed. ampliada e atualizada. Porto Alegre: Editora UFRGS, 2011. SCHOULTS, Lars. Estados Unidos: poder e submissão – uma história da política norte-americana em relação à América Latina. Trad. Raul Fiker. Bauru-SP: EDUSC, 2000. Como citar esse episódio Fronteiras no Tempo #93 Influência dos EUA na América Latina. Locução Marcelo de Souza Silva, Rodolfo Grande Neto, Camila Felix Vidal, Marcos Sorrilha, Willian Spengler e Cesar Agenor Fernandes da Silva [S.l.] Portal Deviante, 06/11/2025. Podcast. Disponível em: https://www.deviante.com.br/?p=66000&preview=true Expediente Produção Geral: C. A. e Beraba. Hosts: Marcelo Beraba e Estagiário Rodolfo. Recordar é viver: Willian Spengler. Artes do Episódio: C. A. Edição: Talk’nCast Madrinhas e Padrinhos Apoios a partir de 12 de junho de 2024 Alexsandro de Souza Junior, Aline Silva Lima, André Santos, André Trapani, Andréa Gomes da Silva, Andressa Marcelino Cardoso, Augusto Carvalho, Carolina Pereira Lyon, Charles Calisto Souza, Edimilson Borges, Elisnei Menezes de Oliveira, Erick Marlon Fernandes da Silva, Flávio Henrique Dias Saldanha, Gislaine Colman, Iara Grisi, João Ariedi, Klaus Henrique de Oliveira, Manuel Macias, Marlon Fernandes da Silva, Pedro Júnior Coelho da Silva Nunes, Rafael Henrique Silva, Raul Sousa Silva Junior, Renata de Souza Silva, Ricardo Orosco, Rodrigo Mello Campos, Rubens Lima e Willian Spengler See omnystudio.com/listener for privacy information.

No episódio 93 do Fronteiras no Tempo, Marcelo Beraba e o Estagiário Rodolfo recebem dois convidados de peso para uma conversa que atravessa décadas de disputas políticas, econômicas e culturais: a professora Camila Feix Vidal (Economia e Relações Internacionais – UFSC) e o professor Marcos Sorrilha (História – UNESP). Juntos, eles exploram a Influência dos Estados Unidos na América Latina, analisando como o poder norte-americano moldou governos, economias, culturas e até imaginários sociais em nosso continente. Da Doutrina Monroe à Guerra Fria, das intervenções militares à dependência econômica, o episódio mergulha nas múltiplas camadas dessa relação complexa – marcada tanto por alianças estratégicas quanto por tensões profundas. Se você quer entender como o "quintal americano" se transformou em um campo de disputas globais e como essas dinâmicas ainda ecoam no presente, este episódio é indispensável. Dá o play e vem com a gente atravessar as fronteiras da história e da geopolítica! Artes do Episódio: C. A. Mencionado no Episódio YOUTUBE (Canal do Sorrilha). Qual é o correto: Americano ou estadunidense? YouTube, 2023. Disponível em: https://www.youtube.com/watch?v=KWKktKCj2Qc A IDADE DOURADA (The Gilded Age). Criação de Julian Fellowes. [Série de televisão]. Estados Unidos: HBO, 2022–. Disponível em: https://www.imdb.com/pt/title/tt4406178/ GREJO, Camila Bueno. Entre a diplomacia e a História: a atuação de Estanislao Zeballos frente ao Panamericanismo. Revista de Historia de América, n. 165, p. 165–191, maio-ago. 2023. ISSN impresso: 0034-8325. ISSN eletrônico: 2663-371X. DOI: https://doi.org/10.35424/rha.165.2023.1106 INSTITUTO DE ESTUDOS LATINO-AMERICANOS (IELA – UFSC). Página institucional. Florianópolis: Universidade Federal de Santa Catarina, [s.d.]. Disponível em: https://iela.ufsc.br/instituto/?ancora=#colaboradores . Acesso em: 4 nov. 2025. INSTITUTO DE ESTUDOS LATINO-AMERICANOS (IELA – UFSC). Canal no YouTube. Florianópolis: Universidade Federal de Santa Catarina, [s.d.]. Disponível em: https://www.youtube.com/@Ielaufsc . Acesso em: 4 nov. 2025. Financiamento Coletivo Existem duas formas de nos apoiar Pix recorrente – chave: fronteirasnotempo@gmail.com Apoia-se – https://apoia.se/fronteirasnotempo Redes Sociais Twitter, Facebook, Youtube, Instagram Contato fronteirasnotempo@gmail.com Material Complementar ANDREWS, George Reide. América Afro-Latina (1800-2000). trad. Magda Lopes. São Carlos: EDUFSCAR, 2007 DULCI, Tereza Maria Spyer. As conferências Pan-Americanas (1889 a 1928): identidades, união aduaneira e arbitragem. São Paulo: Alameda Casa Editorial, 2013. FITZ, Caitlin Annette. Our Sister Republics: The United States in an Age of American Revolutions. New York: W.W. Norton & Company, 2016. PECEQUILO, Cristina Soreanu. A política externa dos Estados Unidos. 3. ed. ampliada e atualizada. Porto Alegre: Editora UFRGS, 2011. SCHOULTS, Lars. Estados Unidos: poder e submissão – uma história da política norte-americana em relação à América Latina. Trad. Raul Fiker. Bauru-SP: EDUSC, 2000. Como citar esse episódio Fronteiras no Tempo #93 Influência dos EUA na América Latina. Locução Marcelo de Souza Silva, Rodolfo Grande Neto, Camila Felix Vidal, Marcos Sorrilha, Willian Spengler e Cesar Agenor Fernandes da Silva [S.l.] Portal Deviante, 06/11/2025. Podcast. Disponível em: https://www.deviante.com.br/?p=66000&preview=true Expediente Produção Geral: C. A. e Beraba. Hosts: Marcelo Beraba e Estagiário Rodolfo. Recordar é viver: Willian Spengler. Artes do Episódio: C. A. Edição: Talk’nCast Madrinhas e Padrinhos Apoios a partir de 12 de junho de 2024 Alexsandro de Souza Junior, Aline Silva Lima, André Santos, André Trapani, Andréa Gomes da Silva, Andressa Marcelino Cardoso, Augusto Carvalho, Carolina Pereira Lyon, Charles Calisto Souza, Edimilson Borges, Elisnei Menezes de Oliveira, Erick Marlon Fernandes da Silva, Flávio Henrique Dias Saldanha, Gislaine Colman, Iara Grisi, João Ariedi, Klaus Henrique de Oliveira, Manuel Macias, Marlon Fernandes da Silva, Pedro Júnior Coelho da Silva Nunes, Rafael Henrique Silva, Raul Sousa Silva Junior, Renata de Souza Silva, Ricardo Orosco, Rodrigo Mello Campos, Rubens Lima e Willian Spengler See omnystudio.com/listener for privacy information.

Today, Jenny and Mr. John dig into some new research and more real talk yet again! From optimal resistance training or results to ultraprocessed foods and putting an end to type 1 diabetes, the research is coming in hot! And don;t miss John's Real Talk about education in the fitness fields- it comes in many shapes and ways! Happy listening!References: 1. Comparable Strength and Hypertrophic Adaptations to Low-Load and High-Load Resistance Exercise Training in Trained Individuals: Many Roads Lead to RomeKristoffer Toldnes Cumming, Ingrid Cecelia Elvatun, Richard Kalenius, Gordan Divljak, Truls Raastad, Niklas Psilander, Oscar Horwath bioRxiv 2025.04.28.650925; doi: https://doi.org/10.1101/2025.04.28.6509252. Samuel J. Dicken, Friedrich C. Jassil, Adrian Brown, Monika Kalis, Chloe Stanley, Chaniqua Ranson, Tapiwa Ruwona, Sulmaaz Qamar, Caroline Buck, Ritwika Mallik, Nausheen Hamid, Jonathan M. Bird, Alanna Brown, Benjamin Norton, Claudia A. M. Gandini Wheeler-Kingshott, Mark Hamer, Chris van Tulleken, Kevin D. Hall, Abigail Fisher, Janine Makaronidis, Rachel L. Batterham. Ultraprocessed or minimally processed diets following healthy dietary guidelines on weight and cardiometabolic health: a randomized, crossover trial. Nature Medicine, 2025; DOI: 10.1038/s41591-025-03842-03. Mayo Clinic. "This sugar molecule could stop type 1 diabetes, by fooling the immune system." ScienceDaily. www.sciencedaily.com/releases/2025/08/250802022917.htm (accessed August 2, 2025).

Welcome to this episode of Mind the Kids, the podcast from the Association for Child and Adolescent Mental Health. In an episode titled 'Income(ing): Poverty and Resilience' Dr. Jane Gilmour and Professor Umar Toseeb are joined by Dr. Divyangana Rakesh from King's College London, to discuss her groundbreaking research on cognitive resilience among children growing up in poverty. The discussion centers on the paper 'Beyond the Income Achievement Gap: The Role of Individual, Family, and Environmental Factors in Cognitive Resilience Among Low-Income Youth' published in JCPP Advances. You can access the full article via DOI: 10.1002/jcv2.12297. Dr. Rakesh shares insights into how some children manage to thrive cognitively despite economic hardship. As she explains, “Although growing up in poverty carries many risks, some children defy the odds and demonstrate positive cognitive outcomes. Identifying factors that promote such resilience in disadvantaged contexts is essential for informing interventions and policies.” She highlights the crucial role of family, community, and individual factors that can foster resilience and improve educational outcomes. Join us as we explore the complex interplay of these factors and what they mean for child mental health and societal action. This episode is essential listening for anyone invested in understanding and supporting young people's development in disadvantaged contexts. Don't forget to like, subscribe, and share with your networks.

BUFFALO, NY — November 5, 2025 — A new #research paper was #published in Volume 17, Issue 10 of Aging-US on September 10, 2025, titled “Longitudinal associations of epigenetic aging with cognitive aging in Hispanic/Latino adults from the Hispanic Community Health Study/Study of Latinos.” In this study led by Myriam Fornage, from The University of Texas Health Science Center at Houston, researchers found that faster biological aging, measured by DNA-based epigenetic clocks, is associated with greater cognitive decline and higher risk of mild cognitive impairment (MCI) in Hispanic/Latino adults. The results highlight the potential of epigenetic clocks to track changes in brain health over time, helping improve early detection and monitoring of age-related cognitive problems. Cognitive decline and dementia are major public health concerns, especially among aging populations. In this study, researchers followed 2671 Hispanic/Latino adults (average age 57; 66% women) over a seven-year period. They measured each participant's biological age using epigenetic clocks and assessed their cognitive performance at two time points. “We evaluated the associations of 5 epigenetic clocks and their between-visit change with multiple measures of cognitive aging that included a global and domain-specific cognitive function score at each visit, between-visit change in global and domain-specific cognitive function score, and MCI diagnosis at visit 2 (V2).” Epigenetic clocks estimate biological age based on DNA chemical modifications, called methylation, that accumulate with age. The study evaluated five different clocks, including newer models like GrimAge and DunedinPACE, which are designed to more accurately reflect health-related aging. The researchers found that individuals with faster biological aging showed lower cognitive function and higher probability of developing MCI over time. Among the five clocks studied, newer models such as GrimAge and DunedinPACE showed the strongest associations with memory, processing speed, and overall brain health. These findings suggest that tracking changes in biological age over time may be more effective than relying on a single measurement to identify those at risk for cognitive impairment. Importantly, the associations between biological aging and cognitive decline remained significant even after accounting for other known risk factors such as education, language preference, and cardiovascular health. This supports the idea that epigenetic clocks capture unique biological processes that influence brain aging. The study also found that the impact of changes in biological age over time was comparable to that of APOE4, a well-established genetic risk factor for Alzheimer's disease. Overall, this is the first large-scale study to examine these associations in a Hispanic/Latino population, a group that is underrepresented in aging research. By identifying early biological signs of brain aging, this work highlights the potential of epigenetic clocks as tools for routine health assessments. Monitoring changes in these biological markers could help detect individuals at risk for cognitive decline and guide timely interventions to preserve brain health. DOI - https://doi.org/10.18632/aging.206317 Corresponding author - Myriam Fornage - Myriam.Fornage@uth.tmc.edu Abstract video - https://www.youtube.com/watch?v=kG0Y-F_sods To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@Aging-US LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Se libérer de nos fantômes coloniaux Enfant, Malek, réalisateur algérien exilé en France, allait à Boufarik, en Algérie, pour manger des oranges. Il y croisait la statue d'un soldat en armes, juchée sur son piédestal à plus de 7 mètres 50 de haut. C'était la statue du sergent Blandan, héros de la conquête coloniale de l'Algérie, érigée à Boufarik à la fin du XIXème siècle et "rapatriée" en France, à Nancy. C'est là que par hasard, un matin neigeux de 1990, Malek a retrouvé le fantôme de son enfance. Le refoulé colonial a soudain ressurgi. Il a raconté sa rencontre effrayante à sa fille, qui à son tour décide de partir sur les traces de ce fantôme, en France et en Algérie. Mais à mesure qu'elle s'approche de lui, elle est à son tour hantée. Comment se libérer du fantôme colonial qui fait corps avec la statue du sergent Blandan, héros de la conquête de l'Algérie ?Avec :Malek Kellou, Susana Gállego Cuesta, Kenza-Marie Safraoui, Don Quichotte, habitants de NancyBibliographie :Gilbert Meynier, « L'Algérie et les Algériens sous le système colonial. Approche historico historiographique», Insaniyat / إنسانيات [En ligne], 65-66 | 2014. URL : http://journals.openedition.org/insaniyat/14758 ; DOI : https://doi.org/10.4000/insaniyat.14758Pour aller plus loin :- Karima Lazali, Le Trauma colonial : une enquête sur les effets psychiques et politiques contemporains de l'oppression coloniale en Algérie, Paris, La Découverte, 2018 ; - Alain Ruscio, La première guerre d'Algérie. Une histoire de conquête et de résistance, 1830-1852, Paris, La Découverte, 2024 ; - Benjamin Stora, La gangrène et l'oubli. La mémoire de la guerre d'Algérie, Paris, La Découverte, 1991 ; - Dorothée-Myriam Kellou, Nancy-Kabylie, Paris, Grasset, 2023.Remerciements :Malek Kellou, Susana Gállego Cuesta, Kenza-Marie Safraoui, le Musée des Beaux-Arts de Nancy, Etienne Augris, Bachir Ahdouga, Don Quichotte, Perrine Kervran, Mathilde Guermonprez, Mathieu Nicol. Prise de son, entretien et montage Dorothée-Myriam Kellou Enregistrements octobre-novembre 2024 Réalisation et mixage Annabelle Brouard Chanson "La casquette du père Bugeaud", chant militaire de l'Armée d'Afrique écrit en 1846 Illustration Pierre Place Production ARTE Radio

BUFFALO, NY — November 3, 2025 — A new #research paper featured on the #cover of Volume 17, Issue 10 of Aging-US was #published on October 20, 2025, titled “Brain region-specific and systemic transcriptomic alterations in a human alpha-synuclein overexpressing rat model.” In this study, led by first author Vivien Hoof and corresponding author Thomas Hentrich from Saarland University, Germany, researchers investigated how excess alpha-synuclein—a protein linked to Parkinson's disease—affects gene activity in different brain regions and the gut. They found that early, region-specific gene disruptions may contribute to the appearance of disease, with some effects also detected in the gut. These early molecular changes could serve as biomarkers for Parkinson's and point to new directions for treatment. Alpha-synuclein accumulates in the brains of individuals with Parkinson's disease and other age-related neurological conditions known as synucleinopathies. To better understand this process, the research team used a genetically modified rat model that overexpresses human alpha-synuclein. They studied gene expression in the striatum, cortex, and cerebellum—three key brain regions involved in movement and cognition—and analyzed how these changes evolved with age. “Transcriptomic analyses were performed on gene and transcript level of striatal, frontocortical, and cerebellar tissue in 5- and 12-month-old transgenic (BAC SNCA) and wild type rats […]” The results showed that gene alterations appeared earlier and were more pronounced in young rats, particularly in the striatum and cortex, before any visible signs of disease manifested. This early disruption challenges the common belief that gene alterations gradually increase with age and suggests that early-life molecular changes may be critical in disease development. The researchers also found that many gene expression changes were unique to individual brain regions. However, they identified a set of genes that were consistently affected across all brain regions and the gut. This suggests that the disease may begin to affect the entire body—not just the brain—long before symptoms become noticeable. Several of the shared genes are involved in synaptic signaling and inflammation—processes known to be altered in Parkinson's. Others are linked to dopamine production and neuronal plasticity, indicating potential early efforts by the brain to compensate for the harmful effects of the alpha-synuclein buildup. Overall, this study provides a detailed view of how alpha-synuclein affects gene networks early in the disease process. Understanding these changes may help identify biomarkers and develop targeted therapies before irreversible brain damage occurs. DOI - https://doi.org/10.18632/aging.206331 Corresponding author - Thomas Hentrich - thomas.hentrich@uni-saarland.de Abstract video - https://www.youtube.com/watch?v=Yl6AfVchkb0 Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206331 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, alpha-synuclein, transgenic rat model, different brain regions, transcriptome analysis To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@Aging-US LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Taking folic acid prior to conception and during pregnancy can help protect the unborn baby from developing abnormalities. Supplements are particularly important for women who have epilepsy, as anti-seizure medication (previously known as anti-convulsants or anti-epileptic drugs) can lead to a deficiency in folic acid. Until 2023, high doses of 4-5 mg per day were recommended. However, this has changed as the data has changed. Did you know the SMFM no longer recommends “high dose” folic acid preconceptionally for patients on seizure medications? This is also highlighted in a recently released epub from Obstetrics and Gynecology (Green Journal) on October 31, 2025. Listen in for details. 1. Mokashi, Mugdha MD, MPH; Cozzi-Glaser, Gabriella MD; Kominiarek, Michelle A. MD, MS. Dietary Supplements in the Perinatal Period. Obstetrics & Gynecology ():10.1097/AOG.0000000000006098, October 31, 2025. | DOI: 10.1097/AOG.00000000000060982. Asadi-Pooya AA. High dose folic acid supplementation in women with epilepsy: are we sure it is safe? Seizure. 2015 Apr;27:51-3. doi: 10.1016/j.seizure.2015.02.030. Epub 2015 Mar 7. PMID: 25891927.3. https://aesnet.org/about/aes-press-room/press-releases/guideline-issued-for-people-with-epilepsy-who-may-become-pregnant4. Turner C, McIntosh T, Gaffney D, Germaine M, Hogan J, O'Higgins A. A 10-year review of periconceptual folic acid supplementation in women with epilepsy taking antiseizure medications. J Matern Fetal Neonatal Med. 2025 Dec;38(1):2524094. doi: 10.1080/14767058.2025.2524094. Epub 2025 Jun 30. PMID: 40588438.5. https://www.aan.com/PressRoom/Home/PressRelease/5170#:~:text=The%20guideline%20recommends%20that%20people,and%20possibly%20improve%20neurodevelopmental%20outcomes.6. https://aesnet.org/about/aes-press-room/press-releases/guideline-issued-for-people-with-epilepsy-who-may-become-pregnant

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A growing number of patients with stubborn IBS symptoms are asking: if the gut and brain are wired together, could changing one transform the other? In this episode, we sit down with Dr. Emeran Mayer and Dr. Erin Mauney to explore what the emerging field of psychedelic-assisted therapy could mean for gut-brain health, beyond the headlines and hype. In this episode we cover:Why traditional IBS treatments often fall short.How psilocybin opens a neuroplastic “window” for processing pain, stress, and interoception.The therapeutic process: preparation, guided dosing, and integration.Early study results: symptom relief, reduced visceral sensitivity, and improved self-illness separation.Safety, variability, and practical questions about access and candidacy.If you're curious about neuroplasticity, the brain-gut axis, psilocybin, and the future of IBS care, this episode offers a grounded, hopeful, and responsible guide to what's known, and what's next. This episode is sponsored by GI Psychology. References: Psychedelic-assisted therapy: An overview for the internistBarnett BS, Mauney EE, King F 4th. Psychedelic-assisted therapy: An overview for the internist. Cleve Clin J Med. 2025;92(3):171-180. Published 2025 Mar 3. doi:10.3949/ccjm.92a.24032Psychedelic-assisted Therapy as a Promising Treatment for Irritable Bowel SyndromeMauney, Erin MD*; King, Franklin IV MD†; Burton-Murray, Helen PhD‡; Kuo, Braden MD‡. Psychedelic-assisted Therapy as a Promising Treatment for Irritable Bowel Syndrome. Journal of Clinical Gastroenterology 59(5):p 385-392, May/June 2025. | DOI: 10.1097/MCG.0000000000002149 Psilocybin and IBS treatment: First psychedelic study in gastroenterologyLearn more about the MGH study with Dr. Erin Mauney and colleagues here.Learn more about Kate and Dr. Riehl:Website: www.katescarlata.com and www.drriehl.comInstagram: @katescarlata @drriehl and @theguthealthpodcastOrder Kate and Dr. Riehl's book, Mind Your Gut: The Science-Based, Whole-body Guide to Living Well with IBS. The information included in this podcast is not a substitute for professional medical advice, examination, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider before starting any new treatment or making changes to existing treatment.

Stephanie C. DeMasi, MD, joins CHEST® Journal Podcast Moderator, Matt Siuba, DO, MS, to discuss her research comparing neurologic outcomes between lower and higher oxygen saturation targets following cardiac arrest.  DOI: 10.1016/j.chest.2025.04.027 Disclaimer: The purpose of this activity is to expand the reach of CHEST content through awareness, critique, and discussion. All articles have undergone peer review for methodologic rigor and audience relevance. Any views asserted are those of the speakers and are not endorsed by CHEST. Listeners should be aware that speakers' opinions may vary and are advised to read the full corresponding journal article(s) for complete context. This content should not be used as a basis for medical advice or treatment, nor should it substitute the judgment used by clinicians in the practice of evidence-based medicine. 

Katarina Zeder, MD, PhD, joins CHEST® Journal Podcast Moderator Matt Siuba, DO, MS, to discuss her research into the ways in which longitudinal pulmonary arterial pressure trajectories inform clinical outcome in patients undergoing kidney transplantation.  DOI: 10.1016/j.chest.2025.05.024 Disclaimer: The purpose of this activity is to expand the reach of CHEST content through awareness, critique, and discussion. All articles have undergone peer review for methodologic rigor and audience relevance. Any views asserted are those of the speakers and are not endorsed by CHEST. Listeners should be aware that speakers' opinions may vary and are advised to read the full corresponding journal article(s) for complete context. This content should not be used as a basis for medical advice or treatment, nor should it substitute the judgment used by clinicians in the practice of evidence-based medicine. 

Eva-Maria Schmolke, MD, and Kathrin Knochel, MD, join CHEST® Journal Podcast Moderator Matt Siuba, DO, MS, to discuss their research into the institutional implementation of a national triage guideline in German ICUs during the initial phases of the COVID-19 pandemic and their subsequent analysis of widespread covert triage as a response to legal uncertainty around triage guidelines.   DOI: 10.1016/j.chest.2025.05.044 Disclaimer: The purpose of this activity is to expand the reach of CHEST content through awareness, critique, and discussion. All articles have undergone peer review for methodologic rigor and audience relevance. Any views asserted are those of the speakers and are not endorsed by CHEST. Listeners should be aware that speakers' opinions may vary and are advised to read the full corresponding journal article(s) for complete context. This content should not be used as a basis for medical advice or treatment, nor should it substitute the judgment used by clinicians in the practice of evidence-based medicine. 

Shaurya Taran, MD, joins CHEST® Journal Podcast Moderator Alice Gallo De Moraes, MD, FCCP, to discuss his research into the association between low-tidal-volume ventilation and mortality in patients with acute brain injuries receiving mechanical ventilation.   DOI: 10.1016/j.chest.2025.06.042 Disclaimer: The purpose of this activity is to expand the reach of CHEST content through awareness, critique, and discussion. All articles have undergone peer review for methodologic rigor and audience relevance. Any views asserted are those of the speakers and are not endorsed by CHEST. Listeners should be aware that speakers' opinions may vary and are advised to read the full corresponding journal article(s) for complete context. This content should not be used as a basis for medical advice or treatment, nor should it substitute the judgment used by clinicians in the practice of evidence-based medicine. 

 What's the episode about? In this episode, hear Dr Jessica Young on assisteddying, the New Zealand End of Life Choice Bill, culturally responsive research, end of life care and decision making, and sociological approaches.Who is Jessica?Dr Jessica Young is a Senior Research Fellow at Victoria University of Wellington and the University of Auckland, and an adjunct senior lecturer in the Australian Centre for Health Law Research, Queensland University of Technology.She is a sociologist specialising in death, dying andassisted dying. She completed her PhD in 2020 at the University of Otago and received a prestigious post-doctoral fellowship from the Cancer Society of New Zealand.Since the End of Life Choice Bill was introduced in NewZealand, Dr Young has been building a programme of research to investigate multiple facets of assisted dying.  She leads and contributes to several projects on assisteddying, most recently ‘Exploring the early experiences of the assisted dying service in Aotearoa', funded by the Health Research Council. Dr Young has led impactful research in end-of-life care, securing over $3 million in competitive funding.  She is the founder and co-chair of New Zealand'sAssisted Dying Research Network and was appointed by the Director-General of Health to the Support and Consultation for End of Life in NZ (SCENZ) Group (2021–2023). Her work has directly shaped national policy: 13 of her team's recommendations were adopted in the Ministry of Health's 2024 End of Life Choice Act Review.She has published over 40 peer-reviewed articles, six editorials, and three book chapters.  To ensure her research goes beyond academia, she activelyengages with media. She is passionate about improving end-of-life experiences for patients, whānau/families and health practitioners. Committed to ethical, inclusive, and culturally responsive research, she seeks to involve tangatawhenua (indigenous people of NZ), stakeholders and communities. You can find Jessica on LinkedIn https://www.linkedin.com/in/jessica-young-7097a722/ The book introduced in the episode introduction is Death, Commemoration, and Cultural Meaning Past and PresentEdited by Robert Spinelli and Robyn S. Lacy. How do I cite the episode in my research and reading lists?To cite this episode, you can use thefollowing citation: Young, J. (2025) Interview on The Death Studies Podcast hosted by Michael-Fox, B. and Visser, R. Published 1 November 2025. Available at: www.thedeathstudiespodcast.com, DOI: 10.6084/m9.figshare.30507878 What next?Check out more episodes or find out more about the hosts! Gota question? Get in touch.

Back on August 9, 2024, we released an episode (link in the show notes) reviewing the renewed interest in transfusing whole blood for PPH rather than component therapy. Now, in O&G open, authors from my Alma Mater (UT Southwestern) have published new data bolstering the use of whole blood for PPH. Listen in for details.1. Clinical Pearls Episode 2024: https://open.spotify.com/episode/0ZhqoIE9wMcAboDlevq9OW?si=rM32uK8ER8uuWmq4mf5dzA2. Ambia, Anne M. MD; Burns, R. Nicholas MD; White, Alesha MD; Warncke, Kristen MD; Gorman, April MS; Duryea, Elaine MD; Nelson, David B. MD. Whole Blood in the Management of Postpartum Hemorrhage. O&G Open 2(5):e130, October 2025. | DOI: 10.1097/og9.00000000000001303. ACPG PB 183STRONG COFFEE PROMO: 20% Off Strong Coffee Company https://strongcoffeecompany.com/discount/CHAPANOSPINOBG

This week we review the results of the new pivotal trial of the 'Minima' stent by Renata Medical. What is special about this new device that makes it particularly desirable for use in small children? How strong is cobalt chromium and what evidence exists that it can be expanded repeatedly over 1-2 decades? Can this technology supplant surgery for certain diseases such as native coarctation? What are the limitations of this device? We speak with the first author of the pivotal trial, Dr. Patrick Sullivan of CHLA who is Associate Professor of Pediatrics at Keck Medicine at USC. DOI: 10.1161/CIRCINTERVENTIONS.125.015618

Feeling knee pain on the bike (or in life)? You're not alone, and it doesn't have to be your norm. In this episode of Making Shift Happen, Jen breaks down why knees hurt (even when your bike fit is fine), why isometric strength training (like wall-sits) is a powerful tool, and how supporting hips and ankles will give your knees the backup they deserve. You'll learn: Why knee pain shows up for cyclists and what real causes are (it's not just your saddle height) How isometric wall-sits and other iso exercises reduce knee/tendon pain and build resilience (evidence included) How to structure your off-season strength and mobility plan for pain-free knees next season Why the upcoming #ShredStrong program (starts Nov 3rd - details below!) is the best way to build the strength system your knees demand Check out these other relevant episodes: This episode also includes the link for the free PDF on bike fit: 219. MTB Gains: Strength Training Secrets with a PT Who Rides  155. Combining Bike Fit and Physical Therapy with Natalie Colins, DPT Research referenced in this episode: PMID 31033611  DOI: 10.2147/OAJSM.S136653 #ShredStrong: Our Fall Cycle Starts on Monday, November 3, 2025! #ShredStrong is my year-round strength training program for mountain bikers and gravel cyclists. You can join any time you want, but we're starting the main Fall cycle in November! Learn more about the program and sign-up HERE!  Do You Want a Coach to Help Make Training & Nutrition Easier and Simpler for You? Hi, it's me.

In this episode of the Epigenetics Podcast, we talked with Vincent Pasque from KU Leuven about his work on the reprogramming of cell identity through epigenetic mechanisms, particularly during early development and cellular reprogramming. We begin by tracing Vincent's journey into biology, sparked by early childhood experiences in nature and meaningful encounters with inspiring teachers. His fascination with the complexities of biology crystallized during a pivotal moment while listening to a radio segment on epigenetics in the late '90s, which led him to pursue studies in genetics and biochemistry. This formative path brought him to leading institutions, including the prestigious lab of John Gurdon, where he explored the phenomenon of nuclear reprogramming. Vincent recounts his early experiments that led to the discovery of macro H2A as a barrier to reprogramming, emphasizing the core challenge of erasing somatic cell identity. As the conversation unfolds, Vincent introduces us to critical findings from his research. He shares how the inactive X chromosome serves as a compelling model to investigate epigenetic regulation, revealing that the dynamics of reprogramming and differentiation are far from simple reversals of development. He highlights the significant differences between male and female iPSCs and how X-linked genes influence DNA methylation and differentiation rates in these cells. The implications of these findings extend beyond developmental biology to inform our understanding of diseases, particularly cancer. Transitioning to his current work, Vincent describes pioneering advances in characterizing the chromatin-associated proteome during the differentiation of human pluripotent stem cells. The surprising discovery of elevated histone modifications in naïve cells leads to intriguing questions about the barriers to cellular plasticity and the mechanisms by which cells resist alternative fate conversions. The potential applications of this research could reshape our approach to regenerative medicine and therapeutic interventions. References Pasque V, Gillich A, Garrett N, Gurdon JB. Histone variant macroH2A confers resistance to nuclear reprogramming. The EMBO Journal. 2011 May;30(12):2373-2387. DOI: 10.1038/emboj.2011.144. PMID: 21552206; PMCID: PMC3116279. Jullien, J., Miyamoto, K., Pasque, V., Allen, G. E., Bradshaw, C. R., Garrett, N. J., Halley-Stott, R. P., Kimura, H., Ohsumi, K., & Gurdon, J. B. (2014). Hierarchical Molecular Events Driven by Oocyte-Specific Factors Lead to Rapid and Extensive Reprogramming. Molecular Cell, 55(4), 524–536. https://doi.org/10.1016/j.molcel.2014.06.024 Pasque V, Tchieu J, Karnik R, et al. X chromosome reactivation dynamics reveal stages of reprogramming to pluripotency. Cell. 2014 Dec;159(7):1681-1697. DOI: 10.1016/j.cell.2014.11.040. PMID: 25525883; PMCID: PMC4282187. Zijlmans DW, Talon I, Verhelst S, et al. Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction. Nature Cell Biology. 2022 Jun;24(6):858-871. DOI: 10.1038/s41556-022-00932-w. PMID: 35697783; PMCID: PMC9203278. Related Episodes The Discovery of Genomic Imprinting (Azim Surani) Gene Expression Control and Intricacies of X-chromosome Inactivation (Claire Rougeulle) Epigenetics and X-Inactivation (Edith Heard) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

Elinzanetant, sold under the brand name Lynkuet, receivedapproval from the U.S. Food and Drug Administration (FDA) on October 24, 2025, for the treatment of moderate to severe hot flashes due to menopause.  How is this different than Fezolinetant, which was approved in 2023? Listen in for details. 1.   Menegaz de Almeida, Artur MS; Oliveira, Paloma MS; Lopes, Lucca MD; Leite, Marianna MS; Morbach, Victória MS; Alves Kelly, Francinny MD; Barros, Ítalo MS; Aquino de Moraes, Francisco Cezar MS; Prevedello, Alexandra MD. Fezolinetant and Elinzanetant Therapy for Menopausal Women Experiencing Vasomotor Symptoms: A Systematic Review and Meta-analysis. Obstetrics & Gynecology 145(3):p 253-261, March 2025. | DOI: 10.1097/AOG.00000000000058122.     Pinkerton JV, Simon JA, Joffe H, Maki PM, NappiRE, Panay N, Soares CN, Thurston RC, Caetano C, Haberland C, Haseli Mashhadi N, Krahn U, Mellinger U, Parke S, Seitz C, Zuurman L. Elinzanetant for the Treatment of Vasomotor Symptoms Associated With Menopause: OASIS 1 and 2 Randomized Clinical Trials. JAMA. 2024 Aug 22;332(16):1343–54. doi: 10.1001/jama.2024.14618. Epub ahead of print. PMID: 39172446; PMCID: PMC11342219.3.     Cardoso F, Parke S, Brennan DJ, Briggs P,Donders G, Panay N, Haseli-Mashhadi N, Block M, Caetano C, Francuski M, Haberland C, Laapas K, Seitz C, Zuurman L. Elinzanetant for Vasomotor Symptomsfrom Endocrine Therapy for Breast Cancer. N Engl J Med. 2025 Aug 21;393(8):753-763. doi: 10.1056/NEJMoa2415566. Epub 2025 Jun 2. PMID: 40454634.STRONG COFFEE PROMO: 20% Off Strong CoffeeCompany https://strongcoffeecompany.com/discount/CHAPANOSPINOBG

This podcast discusses human flourishing in PE. The discussion revolves around Jamie Brunsdon's recent papers on this topic, and I've invited some colleagues for a discussion around this topic that was committed to by all parties at the AIESEP conference in 2025 after a great discussion. The star of the show is Dr. Jamie Brunsdon who is at University of Memphis. Also on the podcast are Obi Atkinson from SUNY Cortland, and Seunghyun Baek also from SUNY Cortland. here are the citations of the two papers we discussed:Jamie Jacob Brunsdon (24 Sep 2024): Human Flourishing as the Aim of Physical Education?, Quest, DOI: 10.1080/00336297.2024.2402710 Brunsdon, J. J. (2024). Toward the virtuous mover: A neo-Aristotelian interpretation of physical education. Physical Education and Sport Pedagogy, 29(6), 588–600. https://doi.org/10.1080/17408989.2022.2135693

בפרק הזה נדבר על המלחמה השקטה שאנשים מנהלים עם הגוף שלהם, מלחמה שהורסת להם את הסיכוי להצליח עם התזונה בטווח הארוך. נדבר גם על הרגע שבו הגוף מפסיק “להרוס” ומתחיל להגן, ועל הדרך שבה אפשר להפוך אותו ממתנגד עקשן לשותף חכם בתהליך. נבין מהי הקשבה חדשה לגמרי לגוף *מבפנים*, איך אכילה רגשית הופכת לשפה שבה הגוף מבקש קשר, ואיך אפשר ללמוד סוף סוף לתרגם את השפה הזו: מרעב לשובע, ממתח לשקט, מביקורת לסקרנות. זה לא עוד פרק על כוח רצון, זו הזמנה לגלות את כוח-החיבור  לאינטלגנציה המדהימה של הגוף, שמכניסה דרך החדשה לרדת מהמלחמה באוכל, מבלי לאבד את עצמך בדרך.   חינם: מדריך מקיף איך להפסיק עם הנשנושים בערב: https://rutifink.vp4.me/night לפרטים על טיפולים אצלינו: https://rutifink.vp4.me/ebge   עקבו אחריי לעוד המון מידע חינמי: אינסטגרם: https://www.instagram.com/rutifink/ טיק-טוק: https://www.tiktok.com/@rutifink פייסבוק: https://www.facebook.com/fink.ruti יוטיוב: https://www.youtube.com/@rutifink לקבלת מייל בכל פעם שיוצא פרק חדש של הפודקאסט: http://rutifink.vp4.me/podcast   רפרנסים: DOI: 10.1038/s41366-021-00950-y DOI: 10.1016/j.physbeh.2021.113434 DOI: 10.1016/j.eatbeh.2014.06.002 DOI: 10.1016/j.appet.2024.107343 DOI: 10.1111/jhn.13176 DOI: 10.1177/1359105317697813 DOI: 10.1016/j.appet.2017.10.013 DOI: 10.1016/j.appet.2025.108143 DOI: 10.1016/j.appet.2016.09.011

On January 18, 2020, we released an episode called “Vaginal Vit C for BV? Yep, it's DATA”. That was 5 years ago! Now, in the Green Journal, a new systematic review and meta-analysis is examining this subject….AGAIN. Plus, this is not the only systematic review to investigate this; a similar review was published in Acta Obstétrica e Ginecológica Portuguesa earlier this year (2025) in March. So, did we get it right 5 years ago? Can vaginal Vit C help in eliminating BV? Listen in for details!1. Khaikin, Yannay MD; Elangainesan, Praniya MD, MSc; Winkler, Eliot MD, MSc; Liu, Kuan PhD, MMath; Selk, Amanda MD, MSc; Yudin, Mark H. MD, MSc. Intravaginal Vitamin C for the Treatment and Prevention of Bacterial Vaginosis: A Systematic Review and Meta-analysis. Obstetrics & Gynecology ():10.1097/AOG.0000000000006092, October 23, 2025. | DOI: 10.1097/AOG.0000000000006092; https://journals.lww.com/greenjournal/pages/articleviewer.aspx?year=9900&issue=00000&article=01389&type=Fulltext2. Acta Obstétrica e Ginecológica Portuguesa (March 2025): chrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/https://scielo.pt/pdf/aogp/v19n1/1646-5830-aogp-19-01-40.pdf3. Chapa Clinical pearls 2020: https://podcasts.apple.com/gh/podcast/vaginal-vit-c-for-bv-yep-its-data/id1412385746?i=1000463002444

Hair Loss in Women” (The New England Journal of Medicine 2025; DOI 10.1056/NEJMcp2412146) 

ASOPRS Website: Click Here Have you ever wanted to know more about aesthetic lasers, but don't know where to start?  Confused by the lingo? Join Dr. Nicole Langelier as she takes Dr. Christina Choe and Dr. Sandy Zhang-Nunes through a whirlwind tour of laser physics, laser terminology, and laser-tissue interactions. We'll explain how lasers work, discuss selective photothermolysis, cover basic skin anatomy, and define workhorse terms like chromophore, wavelength, joules, watts, fluence, thermal relaxation time, and pulse width. Consider this the prequel to upcoming episodes on the clinical uses of ablative laser resurfacing, non-ablative laser resurfacing, light and energy based devices.  By understanding the language and core scientific concepts of lasers, we hope to make you a safer and more educated laser provider!   Corrections/Clarifications: - Blood vessels are lined by endothelium (not epithelium) - The skin registers pain from heat at 45C, but may occur between 43-44C with variability based on the time of exposure and area of exposure (I stated it occurs at 42C) https://www.cardinalhealth.com/content/dam/corp/web/documents/whitepaper/cardinal-health-localized-temperature-therapy%20White%20Paper.pdf - The exact number varies by source, but waters absorbs the erbium 2940nm wavelength 10-20 times more efficiently than it absorbs the CO2 10,600nm wavelength (I said 30 times) - Clarification:  Eyelid skin is thinner closer to the lashes and on the medial aspect of the eyelid as compared to skin further from the lashes and the lateral aspect of the eyelid.  A study in Korean skin by Hwang et al found the thickest part of the eyelid to be just below the eyebrow (1.127 +/- 238um) with the thinnest skin near the ciliary margin 320 +/- 49um).  Jeong et al found that epidermal thickness is similar between genders while men had thicker reticular dermis than women and skin thickness was not correlated with BMI. - The UV wavelengths range from 100nm - 400nm.  UVC: 100nm - 280nm; UVB: 280nm-315nm; UVA: 315-400.  (I used single wavelength numbers rather than a range for ease of explanation).   Citations for skin thickness: Full thickness punch biopsies from cadaver heads processed with paraffin-embedded slides: Karan Chopra, Daniel Calva, Michael Sosin, Kashyap Komarraju Tadisina, Abhishake Banda, Carla De La Cruz, Muhammad R. Chaudhry, Teklu Legesse, Cinithia B. Drachenberg, Paul N. Manson, Michael R. Christy, A Comprehensive Examination of Topographic Thickness of Skin in the Human Face, Aesthetic Surgery Journal, Volume 35, Issue 8, November/December 2015, Pages 1007–1013, https://doi.org/10.1093/asj/sjv079   Ultrasonographic measurements in live participants: Jeong KM, Seo JY, Kim A, Kim YC, Baek YS, Oh CH, Jeon J. Ultrasonographic analysis of facial skin thickness in relation to age, site, sex, and body mass index. Skin Res Technol. 2023 Aug;29(8):e13426. doi: 10.1111/srt.13426. PMID: 37632182; PMCID: PMC10370326.   Cut and trichrome stained specimens from fresh cadavers Hwang, Kun MD, PhD*; Kim, Dae Joong PhD†; Hwang, Se Ho†. Thickness of Korean Upper Eyelid Skin at Different Levels. Journal of Craniofacial Surgery 17(1):p 54-56, January 2006. | DOI: 10.1097/01.scs.0000188347.06365.a0  

On March 7, 2025, we released an episode summarizing key aspects of a NEJM publication regarding male partner therapy for women with recurrent BV. Although that study had limitations, the results were very surprising. Now, on 10/16/25 (7 months later), the ACOG has a new Clinical Practice Update (CPU) on this very issue. In this episode we will briefly summarize that March 2025 NEJM publication and highlight the TWO updated clinical recommendations from the ACOG regarding male partner therapy for the prevention of BV in women. PLUS, we will briefly discuss why although male partner therapy should be considered, partner EPT is “not recommended” at this time by the ACOG. 1. ACOG CLINICAL PRACTICE UPDATE: Concurrent Sexual Partner Therapy to Prevent Bacterial Vaginosis Recurrence Obstetrics & Gynecology ():10.1097/AOG.0000000000006102, October 16, 2025. | DOI: 10.1097/AOG.00000000000061022. Chapa Clinical Pearls March 2025 Episode: https://open.spotify.com/episode/4sW9tTe9CdYVQsCRBjqQQP3. Vodstrcil LA, Plummer EL, Fairley CK, Hocking JS, Law MG, Petoumenos K, et al. Male-partner treatment to prevent recurrence of bacterial vaginosis. N Engl J Med 2025;392:947–57. doi: 10.1056/NEJMoa2405404STRONG COFFEE PROMO: 20% Off Strong Coffee Company https://strongcoffeecompany.com/discount/CHAPANOSPINOBG

This week we review an episode from 3 years back and delve into the world of adult congenital heart disease when we review a recent work from the ACHD team at UCSF that assesses the impact of BMI on clinical outcomes in the single ventricle adult Fontan patient. What is the cause of elevation in BMI in some Fontan patients? Is obesity the only explanation? Is BMI a modifiable risk factor for our Fontan patients and should exercise be 'prescribed' for these patients? If so prescribed, what type of exercise is best for the Fontan patient? This week's work's senior author, Dr. Anushree Agarwal, Assistant Professor of Medicine at UCSF, shares her insights into this important topic. DOI: 10.1161/JAHA.122.026732Also mentioned in today's episode is episode #222 with Dr. Dan Halpern of NYU medical center (https://www.stitcher.com/show/pediheartpediatric-cardiology-today/episode/pediheart-podcast-222-impact-of-cardiac-rehab-on-exercise-tolerance-in-the-achd-patient-206781483)

Podcast family, as we have said on many previous occasions, we get episode suggestions from either real-world patient encounters, from things that are hot in press, and/or from podcasts family member suggestions. Recently, one of our podcast family members asked me about the utility ofperforming pelvic floor muscle therapy (PFMT) antepartum. Is this evidence-based? Does performing PFMT help with postpartum urinary incontinence? Not all PFMTs are Kegel exercises! In this episode, we will review peripartum urinary incontinence and answer the question, “Is there value in teaching antepartum PFMT?”. We will summarize key concepts from the Oct 2025 Narrative Review on thissubject from the Green Journal (Obstet Gynecol).1.     Siddique, Moiuri MD, MPH; Hickman, Lisa MD;Giugale, Lauren MD. Peripartum Urinary Incontinence and Overactive Bladder.Obstetrics & Gynecology 146(4):p 466-472, October 2025. | DOI:10.1097/AOG.00000000000059932.     Woodley SJ, Lawrenson P, Boyle R, et al. PelvicFloor Muscle Training for Preventing and Treating Urinary and Faecal Incontinence in Antenatal and Postnatal Women. The Cochrane Database of SystematicReviews. 2020;5:CD007471. doi:10.1002/14651858.CD007471.pub4.3.     Pelvic Floor Muscle Training to Prevent andTreat Urinary and Fecal Incontinence in Antenatal and Postnatal Patients. AmericanAcademy of Family Physicians (2021). Practice Guideline STRONG COFFEE PROMO: 20% Off Strong CoffeeCompany https://strongcoffeecompany.com/discount/CHAPANOSPINOBG

In the 09/1/2018 Society for Academic Specialists in General Obstetrics and Gynecology's (SASGOG's) Pearls of Exxcellence publication, “Management of Preeclampsia at Term”, it states: “If hypertension management requires acute IV treatment, it is often prudent to initiate oral labetalol or EXTENDED-release nifedipine to maintain blood pressures below the severe range. Intrapartum blood pressure management and consultation should not delay progress towards delivery. Fetal monitoring should be continuous.” In the original ACOG CO 692 from 2017, oral nifedipine was first referenced as an alternative to IV meds GIVEN INTRAPARTUM, stating, “Although relatively less information currently exists for the use of calcium channel blockers for this clinical indication, the available evidence suggests that immediate release oral nifedipine also may be considered as a first-line therapy, particularly when intravenous access is not available.” This may be given orally as 10mg, 20mg, and 20 mg separated in time by 20 minutes per dose. Notice it says “immediate release oral nifedipine”. But what about EXTENDED release nifedipine intrapartum as stated by the SASGOG? Is that an option after immediate attentive and therapy has been given with IV anti-hypertensives? Listen in for details.1. Emergent Therapy for Acute-Onset, Severe Hypertension During Pregnancy and the Postpartum Period: Committee Opinion, Number 692. Obstetrics & Gynecology 129(4):p e90-e95, April 2017. | DOI: 10.1097/AOG.00000000000020192. Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin, Number 222. Obstet Gynecol. 2020 Jun;135(6):e237-e260. doi: 10.1097/AOG.0000000000003891. PMID: 32443079.3. Cleary EM, Racchi NW, Patton KG, Kudrimoti M, Costantine MM, Rood KM. Trial of Intrapartum Extended-Release Nifedipine to Prevent Severe Hypertension Among Pregnant Individuals With Preeclampsia With Severe Features. Hypertension. 2023 Feb;80(2):335-342. doi: 10.1161/HYPERTENSIONAHA.122.19751. Epub 2022 Oct 3. PMID: 36189646.STRONG COFFEE PROMO: 20% Off Strong Coffee Company ⁠https://strongcoffeecompany.com/discount/CHAPANOSPINOBG

“How do we work with gravity to be healthier and stronger?” explains Brennan Spiegel, M.D. Brennan Spiegel, M.D., a physician and professor whose work is focused on how emotion, physical experience, and the mind-body connection shape health, joins us today to explore the emerging field of biogravitational medicine and what it reveals about our relationship with gravity, the body, and health. - What is biograviational medicine? (~3:30) - The connection between health & biogravitational forces (~4:45) - How Spiegel got interested in this topic (~6:40) - How gravity affects IBS (~8:15) - What is EDS? (~12:00) - Holistic approach to gut health (~14:10) - The role of the microbiome & biogravitational medicine (~18:20) - The overarching role of gravity in our health (~24:00) - How to optimize your health through gravity (~26:00) - The effect on mental health (~31:10) -  A protocol for mental resilience (~34:00) - His current research (~35:30) - Accessible ways to improve your health through gravity (~39:35) - The mind-body connection (~41:45) - The role of HRV (~43:35) - Spiegel's dream study (~45:40) - The future of the field (~48:50) Referenced in the episode:  - Follow Spiegel on Instagram (@brennan_spiegel)  - Learn more about Spiegel (www.BrennanSpiegelMD.com)  - Pick up his book, Pull: How Gravity Shapes Your Body, Steadies the Mind, and Guides Our Health. - Check out his podcast (https://thegravitydoctors.com/)  - What's my Gravitype Quiz: https://chatgpt.com/g/g-68a51addf2cc819191559f3fd61d9e7d-what-s-my-gravitype  - Research on gravity's effect on the gut (DOI: 10.14309/ajg.0000000000002066)  - Research on mental gravity (https://doi.org/10.3390/e25091275) We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices