Podcasts about DOI

This week we move into the arena of preventive cardiology when we review a recent report from the team at Northwestern and Princeton on the impact of early childhood food insecurity on cardiovascular health of people in young adulthood. How does food insecurity in young childhood impact the cardiac health of adults? Why is most of the impact seen on BMI but not other measures of cardiovascular health. How can food programs that support improved food and nutrition security work to improve long term cardiovascular health of children and adults? Do the benefits of such programs outweight their costs? Dr. Nilay Shah of Northwestern University shares his deep insights into his work and these questions this week.DOI: 10.1001/jamacardio.2025.1062

BUFFALO, NY - May 23, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on May 19, 2025, titled “Immune-mediated adverse events following atezolizumab and bevacizumab in a multinational Latin American cohort of unresectable hepatocellular carcinoma." The study, led by first authors Leonardo Gomes da Fonseca from Hospital das Clínicas, Universidade de São Paulo, Brazil, and Federico Piñero from Hospital Universitario Austral, Argentina, investigated how patients with advanced liver cancer in Latin America respond to a widely used immunotherapy combination. The researchers found that although a minority of patients developed immune-related side effects, these events did not significantly impact overall survival. Their findings highlight the importance of early recognition and careful management of such side effects in real-world clinical settings. Liver cancer is a leading cause of cancer deaths worldwide, with limited treatment options for patients diagnosed at an advanced stage. Immunotherapy, particularly the combination of atezolizumab and bevacizumab, has become a standard approach. However, these treatments can sometimes trigger the body's immune system to attack healthy organs, leading to what are called immune-related adverse events, or irAEs. Until now, little data existed on how frequently these events occur in Latin American patients and whether they impact treatment outcomes. The researchers followed 99 patients from Argentina, Brazil, Chile, and Colombia, most of whom had cirrhosis or underlying liver disease. They received atezolizumab and bevacizumab for a median duration of six months. The researchers reported that only 18% of the patients experienced immune-related side effects, most commonly affecting the liver (hepatitis) and thyroid (thyroiditis). Most of these cases were mild or moderate, and half of them resolved completely within a month. Only eight patients needed treatment with steroids to control the immune response. Importantly, the occurrence of immune-related side effects did not affect how long patients survived after starting treatment. The median survival was the same—18.5 months—for both those who experienced irAEs and those who did not. This result suggests that while irAEs require careful management, they may not reduce the overall benefits of immunotherapy. Another significant finding was that patients with higher levels of alpha-fetoprotein (AFP), a protein often elevated in liver cancer, were more likely to experience these side effects. This information could help clinicians identify patients who need closer control during treatment. “Notably, baseline alpha-fetoprotein (AFP) values ≥400 ng/ml were significantly associated with the development of irAEs.” The study also points to key differences between clinical trial results and real-world experiences. While clinical trials report higher rates of side effects, this real-world data showed a lower incidence, possibly due to less intensive monitoring or differences in how side effects are documented in everyday practice. In summary, this study highlights that patients require ongoing vigilance and individualized care when treating liver cancer with immunotherapy. It provides valuable information to healthcare providers in Latin America and other regions with similar patient populations, aiming to improve outcomes while minimizing risks. DOI - https://doi.org/10.18632/oncotarget.28721 Correspondence to - Federico Piñero - fpinerof@cas.austral.edu.ar To learn more about Oncotarget, please visit https://www.oncotarget.com. MEDIA@IMPACTJOURNALS.COM

What is the role of ferroptosis, programmed cell death characterized by intracellular iron accumulation and lipid peroxidation, in the context of ischemic injury related to heart transplantation? In this episode, Associate Editor Dr. Amanda LeBlanc (University of Louisville) interviews authors Dr. Kenneth Liao and Dr. Nandan Mondal (both at Baylor College of Medicine), along with expert Dr. Zachary Kiernan (Virginia Commonwealth University) about the latest study by Li et al. The authors found that prolonged cold storage increases the susceptibility of hearts donated after brain death (DBD) to ferroptotic cell death. In contrast, however, the authors found that warm ischemic injury increased the risk for ferroptotic cell death in hearts donated after circulatory death (DCD). Li et al. found that targeting ferroptosis could be beneficial for optimizing cold preservation for DBD hearts, while interventions for DCD hearts should focus on the early phase of warm ischemia. Heart transplantation is the gold standard therapy for patients with medically refractory advanced heart failure. However, demand greatly exceeds supply of donor hearts. Listen as we discuss the current state of the heart transplantation field and the many challenges it faces.   Shiyi Li, Katherine V. Nordick, Abdussalam E. Elsenousi, Rishav Bhattacharya, Randall P. Kirby, Adel M. Hassan, Camila Hochman-Mendez, Todd K. Rosengart, Kenneth K. Liao, and Nandan K. Mondal Warm-ischemia and Cold Storage Induced Modulation of Ferroptosis Observed in Human Hearts Donated After Circulatory Death and Brain Death Am J Physiol Heart Circ Physiol, published March 28, 2025. DOI: 10.1152/ajpheart.00806.2024

BUFFALO, NY - May 21, 2025 – A new #review was #published in Volume 16 of Oncotarget on May 19, 2025, titled “Advancements in bladder cancer treatment: The synergy of radiation and immunotherapy." Researchers from the University of California, Irvine, led by Nazmul Hasan, reviewed recent clinical and scientific advances in combining radiation therapy with immunotherapy for bladder cancer. The article summarizes growing evidence that this combined approach may strengthen the immune response and improve long-term disease control. This strategy is especially important for patients who are not candidates for surgery or who respond poorly to conventional treatments. Bladder cancer is a serious and frequent condition, particularly affecting older men. Traditional treatments—surgery, chemotherapy, and radiation—can be effective, but they often fail to prevent cancer reappearance in advanced cases. The review explores how combining radiation and immunotherapy could improve outcomes by helping the immune system detect and destroy cancer cells more effectively. Radiation therapy destroys cancer cells and triggers the release of tumor signals that attract immune cells. Immunotherapy, including drugs like pembrolizumab and nivolumab, helps the immune system work better by blocking proteins that allow cancer to evade detection. Used together, these treatments may produce a stronger, more widespread anti-tumor effect, even at distant sites not directly targeted by radiation. The review discusses several clinical trials that support this approach. One phase II study reported that combining radiation with the immunotherapy drug durvalumab led to promising survival rates and manageable side effects. Another trial in Australia tested pembrolizumab with radiation and chemotherapy, resulting in high tumor control and extended patient survival. However, the review also points out that other trials showed serious side effects when high doses or multiple immunotherapy drugs were used at once. "Joshi et al. performed a phase II study to determine the safety and efficacy of combining radiation therapy with durvalumab, a PD-L1 inhibitor, in patients who were ineligible for surgery or cisplatin-based chemotherapy." While the combination approach is promising, the authors emphasize that more research is needed to refine this treatment strategy. One major challenge is determining which patients are most likely to benefit. Future studies should focus on identifying reliable biomarkers, such as tumor mutation burden or immune activity, to guide personalized treatment plans. This review highlights the potential of combining radiation and immunotherapy to improve outcomes for bladder cancer patients. With continued research and careful treatment design, this approach could offer new treatment options for those facing aggressive or hard-to-treat forms of the disease. DOI - https://doi.org/10.18632/oncotarget.28723 Correspondence to - Nazmul Hasan - nhasan1@hs.uci.edu Video short - https://www.youtube.com/watch?v=AxrZhIUXrOQ Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28723 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, bladder cancer, immunotherapy, radiation, microenvironment, abscopal To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Day geckos and certain plants share a long evolutionary history, with day geckos feasting on nectar and in return pollinating plants. A study from back in the mid 2000s proved this neatly, and we delve into it this episode. After that, we have a snake eating somebody's underwear, and a very novel new method for controlling invasive cane toads in Australia. Become a Patreon: https://www.patreon.com/herphighlights Merch: https://www.redbubble.com/people/herphighlights/shop Full reference list available here: http://www.herphighlights.podbean.com Main Paper References: Hansen DM, Beer K, Müller CB. 2006. Mauritian coloured nectar no longer a mystery: a visual signal for lizard pollinators. Biology Letters 2:165–168. DOI: 10.1098/rsbl.2006.0458. Other Links/Mentions: Brann M. 2025. Woman finds python eating her bra and shirt for breakfast. ABC News. https://www.abc.net.au/news/2025-02-25/cattle-producer-finds-python-eating-bra-and-shirt/104976022 de Kruijff P. 2025. Cannibal cane toad tadpoles that never grow up could help toad control. ABC News. https://www.abc.net.au/news/science/2025-04-08/cane-toad-created-that-never-grows-up-and-eats-its-siblings/105100286 Editing and Music: Intro/outro – Treehouse by Ed Nelson Species Bi-week theme – Michael Timothy Other Music – The Passion HiFi, https://www.thepassionhifi.com Intro visuals – Paul Snelling

In this spicy episode of The Chad & Cheese Podcast, Joel and Chad sit down with Dr. Joel A. Davis Brown—lawyer, DEI guru, and human BS detector—to ask the big question: Is DEI really dying, or is corporate America just too chicken to say “diversity” out loud? Inside the episode: DEI isn't dead, it's just in hiding—like your CEO when reporters come calling. JP Morgan swaps “DEI” for “DOI” like it's a secret menu item. Smooth move, Jamie. Dr. Brown breaks down why equity matters—using fire drills, because apparently metaphors are the only language execs understand. McKinsey stats say diversity = profits. But sure, let's keep pretending this is just “woke nonsense.” Chad wonders if white guys are scared of 2045. Dr. Brown says: yep, and it's called replacement theory with a side of panic. Performative DEI? Pride flags in June and silence the rest of the year? We see you.

This episode examines I Just Didn't Do It, a 2007 Japanese film written and directed by Masayuki Suo. In the film, 26-year-old Teppei Kaneko (played by Ryo Kase) is traveling to a job interview on a packed Tokyo commuter train when a 15-year-old school girl, who was standing in front of him on the train and whom Kaneko hardly noticed, wrongly accuses him of groping (chikan). Kaneko is  arrested. He is advised by a lawyer to plead guilty and pay a small fine, after which he will be freed. But Kaneko maintains his innocence and decides to fight the case, even though he is told that nearly everyone who takes their case to trial in Japan is convicted. The film then documents Kaneko's nightmare odyssey through the Japanese criminal justice system, where he is detained for months and ultimately convicted despite significant problems with the prosecution's case. I Just Didn't Do It provides important insights into the Japanese criminal justice system and a critique of how it operates, including its treatment of the presumption of innocence.Timestamps: 0:00   Introduction2:52     Background on the Japanese criminal justice system5:19      The crime of groping (chikan) in Japan8:57      The pressure to plead guilty17:12     The interrogation of suspects18:46    Criminal defense lawyers in Japan22:31    Why defendants tend to testify at trial23:52    The prosecution's disclosure obligations28:30    How bail operates in Japan31:04    The rotation of judges in Japan34:06    The incentives in favor of conviction38:44    Finding the defendant guilty despite reasonable doubt43:20    The lay judge (saiban) system in Japan46:54    A critique of Japan's treatment of the presumption of innocenceFurther reading:Aronson, Bruce E. & Johnson, David T., “Comparative Reflections on the Carlos Ghosn Case and Japanese Criminal Justice,” 18 Asia-Pacific Journal 24(2) (Dec. 15, 2020)Doi, Kanae, “Inquiry Needed into Japan's Flawed Criminal Justice System,” Human Rights Watch (Nov. 4, 2024)Japan Federation of Bar Associations, “The Japanese Judicial System”Keiichi, Muraoka & Toshikuni, Murai, “Citizens on the Bench: Assessing Japan's Lay Judge System,” Nippon.com (June 26, 2019) Meehan, Susan, “I Just Didn't Do It,” The Japan SocietyLaw on Film is created and produced by Jonathan Hafetz. Jonathan is a professor at Seton Hall Law School. He has written many books and articles about the law. He has litigated important cases to protect civil liberties and human rights while working at the ACLU and other organizations. Jonathan is a huge film buff and has been watching, studying, and talking about movies for as long as he can remember. For more information about Jonathan, here's a link to his bio: https://law.shu.edu/profiles/hafetzjo.htmlYou can contact him at jonathanhafetz@gmail.comYou can follow him on X (Twitter) @jonathanhafetz You can follow the podcast on X (Twitter) @LawOnFilmYou can follow the podcast on Instagram @lawonfilmpodcast

BUFFALO, NY — May 20, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 4, on April 17, 2025, titled “Dietary associations with reduced epigenetic age: a secondary data analysis of the methylation diet and lifestyle study.” In this study, researchers led by first author Jamie L. Villanueva from the University of Washington and the National University of Natural Medicine, along with corresponding author Ryan Bradley from the National University of Natural Medicine and University of California, investigated how diet influences epigenetic aging. They found that certain plant-based foods containing natural compounds called methyl adaptogens were associated with a decrease in epigenetic age. This effect was measured using DNA methylation, a marker that reflects how the body ages at the cellular level. The findings suggest that targeted food choices may help slow the aging process. Epigenetic age refers to how old a person's cells appear biologically, rather than their actual age in years. DNA methylation patterns, which are chemical tags on DNA, can indicate whether someone is aging faster or slower than expected. For this study, researchers used Horvath's epigenetic clock, a widely accepted tool, to measure changes in epigenetic age. The analysis included healthy men aged 50 to 72 who had previously completed an eight-week program featuring a plant-based, nutrient-rich diet, along with guidance on exercise, sleep, and stress management. Researchers focused on individual dietary differences to understand why some participants experienced greater improvements in epigenetic age than others. The study found that those who ate higher amounts of methyl adaptogen foods—including turmeric, rosemary, garlic, berries, green tea, and oolong tea—experienced greater reductions in epigenetic age. These benefits remained significant even after accounting for weight changes and participants' starting epigenetic age, suggesting that the foods themselves had a direct impact on aging markers. “In hierarchical linear regression, foods investigated as polyphenolic modulators of DNA methylation (green tea, oolong tea, turmeric, rosemary, garlic, berries) categorized in the original study as methyl adaptogens showed significant linear associations with epigenetic age change (B = -1.21, CI = [-2.80, -0.08]), after controlling for baseline epigenetic age acceleration and weight changes.” The natural compounds in methyl adaptogen foods are known to influence how genes behave by affecting DNA methylation. Previous studies have shown that these compounds may support healthy aging and help lower the risk of conditions such as heart disease and cognitive decline. While this study involved a relatively small group of middle-aged men, it adds knowledge to growing global research showing that diets rich in polyphenols—found in vegetables, fruits, and teas—are associated with slower aging. These findings support earlier results from studies on Mediterranean and traditional Japanese diets, both known for their health benefits. Future research should include larger and more diverse populations and use updated epigenetic aging tools to confirm these results. Based on current evidence, this study highlights a practical, food-based strategy that may help reduce epigenetic aging and support long-term health. DOI - https://doi.org/10.18632/aging.206240 Corresponding author - Ryan Bradley - rbradley@nunm.edu To learn more about the journal, connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY – May 19, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on May 9, 2025, titled “Analytical validation of a circulating tumor DNA assay using PhasED-Seq technology for detecting residual disease in B-cell malignancies.” In this study, a team from Foresight Diagnostics led by first author Nina Klimova and corresponding author Laura Hyland validated a new DNA-based blood test designed to detect minimal residual disease (MRD) in patients with B-cell cancers. This assay uses a highly sensitive method called Phased Variant Enrichment and Detection Sequencing (PhasED-Seq) to find tiny fragments of tumor DNA in the blood. Its ultra-sensitive detection capabilities offer a powerful tool for early cancer detection, monitoring treatment response, and predicting cancer reappearance. B-cell lymphomas, such as diffuse large B-cell lymphoma (DLBCL), are among the most prevalent blood cancers. Although many patients respond to initial treatment, up to 40% relapse. Standard monitoring methods such as imaging scans often miss low levels of cancer cells, creating a need for more precise tools. This study introduces a non-invasive blood test that improves the detection of MRD, a critical factor in guiding follow-up care and early intervention. The test works by tracking unique groups of mutations known as phased variants in tumor DNA. These mutations are more specific to cancer and allow for highly accurate identification of tumor fragments in the bloodstream. The PhasED-Seq-based MRD assay was tested on three types of samples. First, blood plasma from healthy individuals was used to confirm the test does not give false positives. Second, researchers created controlled samples by mixing tumor DNA from lymphoma patients with healthy DNA to measure how sensitive and precise the test is. Finally, blood samples from patients with B-cell lymphoma were used to compare the new test to an existing method. Across all sample types, the PhasED-Seq-based MRD assay demonstrated exceptional performance—capable of detecting fewer than one cancer DNA molecule per million normal DNA fragments. It also demonstrated a very low false positive rate and over 96% reproducibility across different laboratory conditions. Compared to an existing method, the new PhasED-Seq assay showed more than 90% agreement in positive results and nearly 78% agreement in negative results. In cases where the tests disagreed, the new method aligned more closely with actual clinical outcomes, including whether patients relapsed or stayed in remission. “The background error rate of the PhasED-Seq-based MRD assay was 1.95E-08, or 1.95 mutant molecules in 100 million informative molecules.” The findings support the use of PhasED-Seq-based MRD assays in routine clinical practice. It could be especially useful for identifying patients who need additional treatment even when imaging results appear normal. This aligns with updated clinical guidelines that encourage the use of blood-based DNA tests to supplement traditional scans in lymphoma care. This study offers strong evidence that the PhasED-Seq-based MRD assay is a precise, reliable, and clinically relevant tool. By detecting signs of cancer earlier and more accurately, it may help clinicians tailor treatments to individual patients and improve long-term outcomes in B-cell malignancies. DOI - https://doi.org/10.18632/oncotarget.28719 Correspondence to - Laura Hyland - laura.hyland@foresight-dx.com Video short - https://www.youtube.com/watch?v=8hdh3G5zvlc Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

In this #episode of the Longevity & Aging Series, Dr. Shubhankar Suman from the Department of Oncology at Georgetown University Medical Center joins host Dr. Evgeniy Galimov to discuss a #research paper he co-authored in Volume 17, Issue 1 of Aging (Aging-US), titled: “Senolytic agent ABT-263 mitigates low- and high-LET radiation-induced gastrointestinal cancer development in Apc1638N/+ mice.” DOI - https://doi.org/10.18632/aging.206183 Corresponding author - Shubhankar Suman - ss2286@georgetown.edu Author interview - https://www.youtube.com/watch?v=ClLO0ERwC0M Video short - https://www.youtube.com/watch?v=M_WEht4vy4w Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206183 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, senescence-associated secretory phenotype, senolytic agent, carcinogenesis, inflammation, β-catenin To learn more about Aging (Aging-US), please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Die auf den ersten Blick sehr einfache Frage, welche Bedeutung Sprache in religiösen Vollzügen habe, führt sehr schnell zu sehr komplexen Antworten, wenn man sich den Sprachen der Religionen und Sprachen in den Religionen zuwendet. Neben Beispielen von Formen der christlichen Verkündigung und Verehrung wenden wir uns im zweiten Teil auch Judentum und Islam zu. Mea culpa: Mosers Monographie als nicht 1968, sondern 1964 erschienen. Präsentation (*.pdf): Alexander Lasch. 2025. Sprache und Religion. Zenodo. DOI: ⁠⁠⁠⁠⁠⁠https://doi.org/10.5281/zenodo.15175420⁠⁠⁠⁠⁠⁠. Videoaufzeichnungen: ⁠⁠⁠⁠⁠⁠https://youtube.com/@AlexanderLasch⁠⁠⁠⁠⁠⁠. Informationen & Material zu allen Vorlesungen: ⁠⁠⁠⁠⁠⁠https://kurzelinks.de/fl7f⁠⁠⁠⁠⁠⁠. Worksheet zu den Vorlesungen: https://kurzlinks.de/WorksheetVorlesungen. Intro: "Reflections" von Scott Holmes (CC BY via ⁠⁠⁠⁠⁠⁠FMA⁠⁠⁠⁠⁠⁠). #Linguistik #OER #Sprache #Sprachwissenschaft #Religion #Religionslinguistik

How do we make artificial intelligence more intelligent? This week, Technology Now dives deep into the world of AI agents and how they interact with large language models. We ask what are some of the current problems with AI, and examine how applying agents can help artificial intelligence to provide better answers to our questions. Jimmy Whitaker, Chief Scientist in the AI Private Cloud Group at HPE, tells us more.This is Technology Now, a weekly show from Hewlett Packard Enterprise. Every week, hosts Michael Bird and Aubrey Lovell look at a story that's been making headlines, take a look at the technology behind it, and explain why it matters to organizations and what can be learnt from it.Jimmy Whitaker: https://www.linkedin.com/in/jimmymwhitaker/Sources cited in this week's episode:Today I learned: https://www.simonsfoundation.org/2025/04/29/flares-from-magnetized-stars-can-forge-planets-worth-of-gold-other-heavy-elements/Anirudh Patel et al., 2025, Direct Evidence for r-process Nucleosynthesis in Delayed MeV Emission from the SGR 1806–20 Magnetar Giant Flare, ApJL 984 L29, DOI 10.3847/2041-8213/adc9b0This week in history:Strassburg MA. The global eradication of smallpox. Am J Infect Control. 1982 May;10(2):53-9. doi: 10.1016/0196-6553(82)90003-7. PMID: 7044193.Muyembe JJ, et al, 2024, Ebola Outbreak Response in the DRC with r-VSV-ZEBOV-GP Ring Vaccination, The New England Journal of Medicine, 2024;391:2327-2336, VOL. 391 NO.24, https://www.nejm.org/doi/10.1056/NEJMoa1904387https://www.who.int/health-topics/poliomyelitis#tab=tab_1

BUFFALO, NY - May 14, 2025 – A new #review paper was #published in Volume 16 of Oncotarget on May 9, 2025, titled “Relationship between ABO blood group antigens and Rh factor with breast cancer: A systematic review and meta-analysis." A comprehensive study, led by first authors Rahaf Alchazal from Yarmouk University and Khaled J. Zaitoun from Johns Hopkins University School of Medicine and Jordan University of Science and Technology, examined the potential link between blood type and breast cancer. The research team conducted a systematic review and meta-analysis of 29 previously published studies, involving more than 13,000 breast cancer patients and over 717,000 controls. “Researchers searched for studies on breast cancer patients and ABO blood groups across four major databases: PubMed, Scopus, Web of Science, and Google.“ Breast cancer is the most common cancer among women worldwide. Identifying risk factors is vital for early detection and prevention. While many studies have explored lifestyle and genetic causes, this analysis focused on the ABO blood group system. By pooling global data, the researchers found that blood type A was the most common among breast cancer patients and was significantly associated with an 18% increased risk compared to type O. The study did not find a significant association between breast cancer and blood types B, AB, or Rh factor. Although the results do not prove causation, they point to a biological pattern worth further investigation. Blood group antigens are proteins found on the surface of cells, including breast tissue. These molecules may influence how cancer develops and spreads by interacting with the immune system or affecting cell behavior. This meta-analysis is the most extensive review to date on this topic, based on studies conducted across Asia, Europe, Africa, and the Americas. While previous research found unclear conclusions, this large-scale evaluation provides stronger evidence for a possible connection between blood type A and breast cancer risk. Researchers note that regional differences, genetic diversity, and study quality may affect individual results. Nevertheless, the overall trend supports considering blood type A as a potential risk marker. This insight could help shape screening guidelines, encouraging earlier or more frequent checkups for women with this blood type. Further research is needed to understand why blood type A may play a role in cancer development. Future studies may explore genetic mechanisms, immune responses, and other biological pathways. These efforts could lead the way for more personalized cancer prevention and care strategies. DOI - https://doi.org/10.18632/oncotarget.28718 Correspondence to - Khaled J. Zaitoun - kzaitou1@jh.edu Video short - https://www.youtube.com/watch?v=BQFVtreaetI Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28718 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, breast cancer, cancer risk factors, blood group antigens, tumor To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY — May 14, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 4, on April 10, 2025, titled “Impact of Factor Xa inhibitors on cardiovascular events in older patients with nonvalvular atrial fibrillation.” In this study, first author Masahiko Takahashi and corresponding author Keisuke Okawa led a research team from Kagawa Prefectural Central Hospital and Hyogo Medical University that investigated whether Factor Xa inhibitors (Xa-Is)—a type of blood thinner—can reduce the risk of heart-related complications in patients over 80 with nonvalvular atrial fibrillation (NVAF). The study found that patients using Xa-Is experienced significantly fewer cardiovascular problems than those on other anticoagulants. This finding is especially relevant, as older adults face a high risk of both stroke and heart disease. Atrial fibrillation is a common heart rhythm disorder, particularly in the elderly, that increases the risk of blood clots, heart failure, and stroke. Anticoagulants are often prescribed to prevent clots, but not all types have the same effects on heart health. This study focused on comparing Xa-Is—specifically rivaroxaban, apixaban, and edoxaban—with commonly used drugs such as warfarin and dabigatran. Researchers followed more than 1,000 patients aged 80 and above for up to five years to assess the long-term impact of these medications on cardiovascular outcomes. Patients who used Xa-Is had significantly lower rates of heart failure, artery disease, and cardiovascular death. The risk of cardiovascular problems in the Xa-I group was less than half that of those on non-Xa-I medications. These benefits remained even after adjusting for factors like age, existing heart conditions, and kidney function. Additionally, stroke and all-cause death rates were notably lower in the Xa-I group. “Xa-Is may be useful for not only anticoagulation but also the prevention of cardiovascular events in very old patients with NVAF.” What makes Xa-Is different, according to the researchers, is their ability to inhibit a specific biological pathway—known as Factor Xa–PAR2—that contributes to inflammation, fibrosis, and damage in blood vessels and heart tissue. This effect extends beyond their traditional role in preventing blood clots. Although the study was conducted at a single medical center in Japan, its rigorous design and long follow-up period enhance the reliability of the findings for real-world clinical decision-making. While further studies, especially across multiple centers, are needed to confirm the full range of benefits, this study strongly suggests that Xa-Is may offer broader cardiovascular protection for very old patients. The findings could influence how clinicians choose blood thinners for elderly individuals with atrial fibrillation, potentially improving both survival and quality of life in this growing population. DOI - https://doi.org/10.18632/aging.206238 Corresponding author - Keisuke Okawa - k-ookawa@chp-kagawa.jp Video short - https://www.youtube.com/watch?v=YtbYpfVDVDI Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206238 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, Factor Xa inhibitor, atrial fibrillation, older patient, cardiovascular events To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

A new study has proven that ancient iguanas rafted over sea all the way from North America to Fiji, a staggering 8,000 km away. We discuss this epic voyage, and then turn our attention to a colourful new species of wolf snake from Myanmar.  Become a Patreon: https://www.patreon.com/herphighlights Merch: https://www.redbubble.com/people/herphighlights/shop Full reference list available here: http://www.herphighlights.podbean.com Main Paper References: Scarpetta SG, Fisher RN, Karin BR, Niukula JB, Corl A, Jackman TR, McGuire JA. 2025. Iguanas rafted more than 8,000 km from North America to Fiji. Proceedings of the National Academy of Sciences 122:e2318622122. DOI: 10.1073/pnas.2318622122. Species of the Bi-Week: Van Nguyen T, Lee Jl, Jiang K, Ding L, Chit Mat, Poyarkov Na, Vogel G. 2025. A new species of wolf snake Lycodon Fitzinger, 1826 from China and Myanmar (Squamata: Colubridae), and new data on Lycodon gongshan Vogel & Luo, 2011. Zootaxa 5621:1–51. DOI: 10.11646/zootaxa.5621.1.1. Other Links/Mentions: Bakar F. 2019.Frogs who married “to bring rain” to Indian village get divorced. Available at https://metro.co.uk/2019/09/15/frogs-who-married-to-bring-rain-to-indian-village-get-divorced-because-of-too-much-downpour-10745884/ (accessed April 30, 2025). Editing and Music: Intro/outro – Treehouse by Ed Nelson Species Bi-week theme – Michael Timothy Other Music – The Passion HiFi, https://www.thepassionhifi.com Intro visuals – Paul Snelling

Send us a textCorrine Wickens talks to us about self-efficacy and identity, teaching as coaching and a translational act, and challenging our assumptions. Corrine is known for her work in the areas of adolescent literacies, disciplinary literacies, and gender and sexuality. Her research interests examine issues of ongoing discourses around sexuality and schooling, gender and sexual characterizations in contemporary young adult literature, and disciplinary-based literacies in secondary teacher education. Her work has appeared in journals like TESOL Quarterly, Children's Literature Association Quarterly, Voices from the Middle, Journal of Adolescent and Adult Literacy, Urban Review, Journal of Teaching Physical Education, Sex Roles, and International Journal of Qualitative Studies in Education. Dr. Wickens is currently a professor of literacy education and serves as the doctoral program coordinator in the Department of Curriculum and Instruction at Northern Illinois University.To cite this episode: Persohn, L. (Host). (2025, May 13). A conversation with Corrine Wickens. (Season 5, No. 10) [Audio podcast episode]. In Classroom Caffeine Podcast series. https://www.classroomcaffeine.com/guests. DOI: 10.5240/C98D-5781-A685-2545-D3D1-0 Connect with Classroom Caffeine at www.classroomcaffeine.com or on Instagram, Facebook, Twitter, and LinkedIn.

BUFFALO, NY — May 13, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 4, on April 7, 2025, titled “Pharmacological recapitulation of the lean phenotype induced by the lifespan-extending sulfur amino acid-restricted diet.” In this study, the research team, led by first author Naidu B. Ommi and corresponding author Sailendra N. Nichenametla from the Orentreich Foundation for the Advancement of Science Inc., investigated whether the drug buthionine sulfoximine (BSO) could replicate the effects of sulfur amino acid restriction (SAAR), a challenging diet known to reduce obesity. The study found that BSO produced similar reductions in fat mass and weight gain. This drug-based approach may offer a simpler and safer treatment for obesity, especially for those unable to follow strict dietary plans. Obesity and metabolic disorders raise the risk of chronic illnesses like heart disease, diabetes, and Alzheimer's disease. While SAAR, a diet low in the amino-acids methionine and cysteine, has shown powerful health benefits in animal studies, its translation to humans has been limited by adherence challenges. This new study explored whether BSO, a compound that lowers glutathione (GSH) levels in the body, could mimic SAAR's effects without dietary restriction. Researchers tested four groups of obese mice on high-fat diets. One group received the SAAR diet, another was given a regular diet plus BSO, while two control groups received either no treatment or a supplement that increased GSH levels. The BSO-treated mice showed lower fat mass, reduced liver fat, and prevented weight gain, results comparable to those on the SAAR diet. These benefits occurred without reducing food intake or muscle mass, making BSO a particularly promising treatment option. “BSO mice exhibited all SAAR-induced changes, with two notable differences, i.e., a smaller effect size than that of the SAAR diet and a higher predilection for molecular changes in kidneys than in the liver.” Additional findings revealed that both the SAAR diet and BSO influenced metabolic activity by activating pathways related to fat storage, but they did so in different organs. The SAAR diet had stronger effects in the liver, while BSO acted more in the kidneys. Both interventions increased levels of the amino acid serine, which is associated with lower fat production. Unlike many obesity treatments that suppress appetite or reduce muscle, BSO helped prevent fat accumulation while preserving lean mass and food consumption. No signs of liver or kidney toxicity were observed during the 13-week study, suggesting the drug's safety at the tested dose. Since BSO has previously been evaluated in human clinical trials for other conditions, repurposing it for metabolic diseases may be relatively straightforward. However, the researchers point out that there should be further studies in both animals and humans. If successful, this strategy could provide a practical alternative to difficult-to-maintain diets and help more people manage weight long-term. DOI: https://doi.org/10.18632/aging.206237 Corresponding author: Sailendra N. Nichenametla – snichenametla@orentreich.org Video short - https://www.youtube.com/watch?v=AcCzYTIElGY Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords: aging, buthionine sulfoximine, thiols, serine, anti-obesity drugs To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Tetanus has probably been around for most of human history, or even longer. But it’s preventable today thanks to vaccines. Research: "Emil von Behring." Notable Scientists from 1900 to the Present, edited by Brigham Narins, Gale, 2008. Gale In Context: Science, link.gale.com/apps/doc/K1619001490/GPS?u=mlin_n_melpub&sid=bookmark-GPS&xid=464250e5. Accessed 17 Apr. 2025. Breasted, J.H., translator. “OIP 3. The Edwin Smith Surgical Papyrus, Volume 1: Hieroglyphic Transliteration, Translation, and Commentary.” Oxford University Press. 1930. Chalian, William. “An Essay on the History of Lockjaw.” Bulletin of the History of Medicine, FEBRUARY, 1940, Vol. 8, No. 2. Via JSTOR. https://www.jstor.org/stable/44446242 Emil von Behring: The founder of serum therapy. NobelPrize.org. Nobel Prize Outreach 2025. Thu. 17 Apr 2025. https://www.nobelprize.org/prizes/medicine/1901/behring/article/ Galassi, Francesco Maria et al. “Tetanus: historical and palaeopathological aspects considering its current health impact.” Journal of preventive medicine and hygiene vol. 65,4 E580-E585. 31 Jan. 2025, doi:10.15167/2421-4248/jpmh2024.65.4.3376 George, Elizabeth K. “Tetanus (Clostridium tetani Infection).” StatPearls. January 2025. https://www.ncbi.nlm.nih.gov/books/NBK482484/ Hippocrates. “VI. Diseases, Internal Affections.” Harvard University Press. 1988. Jean-Marc Cavaillon, Historical links between toxinology and immunology, Pathogens and Disease, Volume 76, Issue 3, April 2018, fty019, https://doi.org/10.1093/femspd/fty019 Jones CE, Yusuf N, Ahmed B, Kassogue M, Wasley A, Kanu FA. Progress Toward Achieving and Sustaining Maternal and Neonatal Tetanus Elimination — Worldwide, 2000–2022. MMWR Morb Mortal Wkly Rep 2024;73:614–621. DOI: http://dx.doi.org/10.15585/mmwr.mm7328a1 Kaufmann, Stefan H E. “Remembering Emil von Behring: from Tetanus Treatment to Antibody Cooperation with Phagocytes.” mBio vol. 8,1 e00117-17. 28 Feb. 2017, doi:10.1128/mBio.00117-17 Kreston, Rebecca. “Tetanus, the Grinning Death.” Discover. 9/29/2015. https://www.discovermagazine.com/health/tetanus-the-grinning-death Milto, Lori De, and Leslie Mertz, PhD. "Tetanus." The Gale Encyclopedia of Public Health, edited by Brigham Narins, 2nd ed., vol. 2, Gale, 2020, pp. 1074-1076. Gale In Context: Environmental Studies, link.gale.com/apps/doc/CX7947900274/GPS?u=mlin_n_melpub&sid=bookmark-GPS&xid=a44bc544. Accessed 14 Apr. 2025. Milto, Lori De, and Leslie Mertz, PhD. "Tetanus." The Gale Encyclopedia of Public Health, edited by Brigham Narins, 2nd ed., vol. 2, Gale, 2020, pp. 1074-1076. Gale In Context: Environmental Studies, link.gale.com/apps/doc/CX7947900274/GPS?u=mlin_n_melpub&sid=bookmark-GPS&xid=a44bc544. Accessed 15 Apr. 2025. National Institutes of Health. “Tetanus.” https://history.nih.gov/display/history/Tetanus Ni, Maoshing. “The Yellow Emperor's Classic of Medicine: A New Translation of the Neijing Suwen with Commentary.” Shambhala. 1995. Smithsonian. “The Antibody Initiative: Battling Tetanus.” https://www.si.edu/spotlight/antibody-initiative/battling-tetanus Sundwall, John. “Man and Microbes.” Illustrated lecture given under the auspices of the Kansas Academy of Science, Topeka, January 12, 1917. https://archive.org/details/jstor-3624335/ The Nobel Prize in Physiology or Medicine 1901. NobelPrize.org. Nobel Prize Outreach 2025. Thu. 17 Apr 2025. https://www.nobelprize.org/prizes/medicine/1901/summary/ Tiwari, Tejpratap S.P. et al. “Chapter 21: Tetanus.” CDC Pink Book. https://www.cdc.gov/pinkbook/hcp/table-of-contents/chapter-21-tetanus.html Von Behring, Emil and Kitasato Shibasaburo. “The Mechanism of Immunity in Animals to Diphtheria and Tetanus.” Immunology. 1890. http://raolab.org/upfile/file/20200612164743_201234_56288.pdf War Office Committee for the Study of Tetanus. “Memorandum on Tetanus.” Fourth Edition. 1919. https://archive.org/details/b32171201/ World Health Organization. “Tetanus.” 7/12/2024. https://www.who.int/news-room/fact-sheets/detail/tetanus See omnystudio.com/listener for privacy information.

I'm discussing the truth about "Lifting Heavy" in group fitness.Sources (Research Show Notes)Schoenfeld BJ et al. (2016). Longer Interset Rest Periods Enhance Muscle Strength and Hypertrophy in Resistance-Trained Men. J Strength Cond Res, 30(7):1805-12. PMID: 26605807pubmed.ncbi.nlm.nih.govGrgic J et al. (2017). The effects of short versus long inter-set rest intervals on measures of muscle hypertrophy: A systematic review. Eur J Sport Sci, 17(8): 983-993. PMID: 28641044pubmed.ncbi.nlm.nih.govMcKendry J et al. (2016). Short inter-set rest blunts resistance exercise-induced increases in myofibrillar protein synthesis in young males. Exp Physiol, 101(7): 866-82. PMID: 27126459pubmed.ncbi.nlm.nih.govpubmed.ncbi.nlm.nih.govSchoenfeld BJ. (2010). The mechanisms of muscle hypertrophy and their application to resistance training. J Strength Cond Res, 24(10): 2857-2875.journals.lww.com“Give it a rest” Meta-analysis (Singer et al. 2024). Inter-set Rest Interval Duration and Muscle Hypertrophy: A Bayesian Meta-Analysis. Frontiers in Sports and Active Living. DOI: 10.3389/fspor.2024.1429789frontiersin.orgTopics:(00:08) - Are strength training classes worth doing? (06:14) - This is the problem with "lift heavy" (13:01) - Why does rest period matter? (36:32) - It's not just about aesthetics (41:17) - Hearing this in the spirit I intended

In dieser Vorlesung wenden wir und zentralen Grundkonzepten einer Religionslinguistik zu, vor allem der Kommunikationstypologie von Verkündigung, Veehrung und Vergegenwärtigung und den (für abrahamitische Religionen) besonders relevanten Kommunikationsformen Gebot, Gebet, Lob und Bekenntnis. Eng damit verbunden bleiben -- auch vor dem Hintergrund der Wahl Robert Francis Prevost zu Papst Leos XIV. -- die Konzepte Transzendenz und Macht. Präsentation (*.pdf): Alexander Lasch. 2025. Sprache und Religion. Zenodo. DOI: ⁠⁠⁠⁠⁠⁠⁠https://doi.org/10.5281/zenodo.15175420⁠⁠⁠⁠⁠⁠⁠. Videoaufzeichnungen: ⁠⁠⁠⁠⁠⁠⁠https://youtube.com/@AlexanderLasch⁠⁠⁠⁠⁠⁠⁠. Informationen & Material zu allen Vorlesungen: ⁠⁠⁠⁠⁠⁠⁠https://kurzelinks.de/fl7f⁠⁠⁠⁠⁠⁠⁠. Worksheet zu den Vorlesungen: ⁠https://kurzlinks.de/WorksheetVorlesungen⁠. Intro: "Reflections" von Scott Holmes (CC BY via ⁠⁠⁠⁠⁠⁠FMA⁠⁠⁠⁠⁠⁠). #Linguistik #OER #Sprache #Sprachwissenschaft #Religion #Religionslinguistik

Let's unpack something most midlife women are totally missing – protein for Menopause Hormone Support. Are you feeling moody, low-energy, or constantly craving carbs in midlife? It might not just be your hormones—it could be your protein intake… and its effect on your hormones.  In today's episode, know how protein connects hormones and why your daily meals might be the hormonal tune-up you didn't know you needed. Cortisol & Protein: The Stress-Balance Dance Cortisol levels increase in response to low blood sugar or stress, which are common when meals are high-carb and low-protein. A high-protein diet blunts cortisol spikes post-meal and improves the body's stress response.   Insulin: Protein's Role in Glucose Control Protein stimulates insulin—but in a modulated way that helps with blood sugar stability, not spikes. In midlife and beyond, protein helps preserve insulin sensitivity, especially when combined with resistance training.   Ghrelin & Leptin: Protein vs. Cravings Ghrelin = your hunger hormone. Protein is the most effective macronutrient at suppressing ghrelin. Leptin = satiety hormone. Protein helps regulate leptin sensitivity over time. The Protein theory goes that if the body doesn't get enough protein it will message you it wants more. The problem is the message is not clear. It's just a hunger signal. You're left to figure it out or deal with the tempting cookies, cakes, and chocolate hidden in the icebox.    Estrogen: From Muscle Protector to MIA Estrogen is an anabolic hormone—it supports muscle maintenance, insulin sensitivity, and metabolic efficiency. As estrogen declines in perimenopause and menopause, its natural support of muscle protein synthesis (MPS) disappears. With estrogen no longer stimulating MPS, women must now rely on two primary tools to stimulate it: Resistance training Adequate high-quality protein (especially leucine-rich) “Estrogen enhances the anabolic response of skeletal muscle to both feeding and resistance exercise, and its loss results in anabolic resistance.”   More Truths About Protein for Menopause Hormone Support Muscle Protein Synthesis declines with age—and even more so without estrogen.  This is why RDA-level protein (0.8g/kg) is not sufficient in midlife - a statement agreed on by Registered Dietitians, longevity and geriatric experts alike.  Experts (ISSN) recommend ≥1.6–2.2g/kg of body weight for active women in midlife to maintain muscle, metabolism, and hormonal resilience.   The Anabolic vs. Catabolic Hormone Framework Anabolic Hormones = Build & Repair These are hormones that stimulate tissue growth and regeneration: Testosterone – promotes muscle growth, strength, libido Growth Hormone (GH) – supports repair, recovery, and fat metabolism Estrogen – helps preserve lean mass, regulates insulin sensitivity Insulin – can be anabolic by shuttling nutrients into cells, especially post-exercise Protein intake supports all of these by providing the amino acid building blocks needed for anabolic activity. Catabolic Hormones = Break DownThese are hormones that promote the breakdown of muscle, tissue, and energy stores: Cortisol – breaks down muscle for glucose during stress Epinephrine/Norepinephrine – mobilize energy in fight-or-flight Chronically elevated catabolic hormones + low protein = muscle loss, cravings, fatigue. Fat Storage Insulin isn't actually a catabolic hormone but it does increase fat storage. You can't be burning fat if insulin is high, as is true for many women. Focusing on boosting the anabolic hormones is the game-changer.    Other Episodes You Might Like: Previous Episode - Can We Just Stop the Self Sabotage to Feel Your Best Ever  Next Episode - How and Why to Consider Meditation in Menopause More Like This - Where Protein Recommendations for Women Come From?   Resources:  This episode is brought to you by Flipping 50 Longevity Pro Protein & Fiber, the simplest ingredient, cleanest, third-party-tested protein powder formulated specifically for midlife metabolism. No bloat, no fillers, just functional fuel. Use code PODCAST10 for 10% off at checkout.   References:  Lemmens SG, Born JM, Martens EA, Martens MJ, Westerterp-Plantenga MS. PLoS One. 2011 Feb 3;6(2):e16826. doi: 10.1371/journal.pone.0016826. PMID: 21304815; PMCID: PMC3033415. Layman et al., 2008 reported that diets with higher protein and lower carbs improved insulin sensitivity in adults. DOI: 10.1093/jn/138.3.514 Leidy HJ, Ortinau LC, Douglas SM, Hoertel HA. Am J Clin Nutr. 2013 Apr;97(4):677-88. doi: 10.3945/ajcn.112.053116. Epub 2013 Feb 27. PMID: 23446906; PMCID: PMC3718776. Tang JE, Moore DR, Kujbida GW, Tarnopolsky MA, Phillips SM. J Appl Physiol (1985). 2009 Sep;107(3):987-92. doi: 10.1152/japplphysiol.00076.2009. Epub 2009 Jul 9. PMID: 19589961.  

Welcome to the PRESSURISED version of episode 58, just the science, none of the waffle   We are still talking about Antarctica, the continent that keeps on giving!   For this month's interview, we speak with Devin Harrison - Marine Geoscientist/Postdoctoral Researcher at Kelpie Geoscience - Devin is a postdoctoral research fellow at Kelpie Geoscience. His research utilises high-resolution topographic models of the seafloor and complementary geophysical and geospatial datasets to understand the geomorphic evolution and process landform relationship of the deep sea and the continental shelves. Devin is particularly interested in the glacial geomorphological record and the evolution of glacial environments from the last glacial maximum (~20-25 thousand years ago) to the present day.   We're really trying to make this project self-sustaining, so we have started looking for ways to support the podcast. Here's a link to our page on how to support us, from the free options to becoming a patron of the show. We want to say a huge thank you to those patrons who have already pledged to support us: Elena Thanks again for tuning in; we'll deep-see you next time!   Check out our podcast merch here!   Feel free to get in touch with us with questions or your own tales from the high seas on: podcast@deepseapod.com We'd love to actually play your voice so feel free to record a short audio note!   We are also on  BlueSky: @deepseapod.com Twitter: @DeepSeaPod Instagram: @deepsea_podcast   Keep up with the team on social media Twitter:  Alan - @Hadalbloke Thom - @ThomLinley  Instagram:  Thom - @thom.linley  Inkfish - @inkfishexpeditions BlueSky: Thom @thomaslinley.com   Reference list Dowdeswell, J.A., Canals, M., Jakobsson, M., Todd, B.J., Dowdeswell, E.K. and Hogan, K. (eds.), 2016. Atlas of Submarine Glacial Landforms: Modern, Quaternary and Ancient, The Geological Society of London, London. vol. 46, 618pp. doi:10.1144/M46.   Batchelor, C.L., Christie, F.D.W., Ottesen, D., Montelli, A., Evans, J., Dowdeswell, E.K., Bjarnadóttir, L.R. and Dowdeswell, J.A., 2023. Rapid, buoyancy-driven ice-sheet retreat of hundreds of metres per day. Nature, vol. 617, issue 7959, p.105-110. Doi:10.1038/s41586-023-05876-1.     Smith, J.A., Graham, A.G.C., Post, A.L. et al. The marine geological imprint of Antarctic ice shelves. Nat Commun 10, 5635 (2019).   Seafloor surficial sediment variability across the abyssal plains of the central and eastern Pacific Ocean   Credits Theme: Hadal Zone Express by Märvel Logo image: Lance Wordsworth (Inkfish Media)

BUFFALO, NY - May 9, 2025 – A new #research paper was #published in Oncotarget, Volume 16, on May 8, 2025, titled “METTL3 promotes oral squamous cell carcinoma by regulating miR-146a-5p/SMAD4 axis." In this study, researchers Jayasree Peroth Jayaprakash, Pragati Karemore, and Piyush Khandelia from the Birla Institute of Technology and Science, India, discovered that a molecule called METTL3 contributes to the development and spread of oral squamous cell carcinoma (OSCC). The study shows that METTL3 increases the levels of a small RNA molecule called miR-146a-5p, which blocks SMAD4, a key tumor-suppressing gene. These findings help explain why oral cancers are difficult to treat and may offer a new target for more effective therapies. Oral squamous cell carcinoma is a common and aggressive cancer affecting the mouth and throat. It has a high death rate, mainly due to late detection, treatment resistance, and the cancer's ability to invade nearby tissues. In this study, the researchers focused on METTL3, an enzyme that adds chemical tags known as m6A marks to RNA, which change how genetic information is used by cells. They found that METTL3 is unusually active in OSCC cells, causing an increase in miR-146a-5p. This molecule, in turn, blocks the function of SMAD4, which helps control how cells grow and die in our bodies. “METTL3, the primary m6A RNA methyltransferase, is significantly upregulated in OSCC cells leading to increased global m6A levels.” When METTL3 was reduced or chemically blocked, miR-146a-5p levels dropped and SMAD4 levels increased. This shift slowed the growth of cancer cells, increased their death, and made them less likely to spread. When researchers reintroduced miR-146a-5p or lowered SMAD4 levels again, the cancer-promoting behavior returned. These results show that the METTL3–miR-146a-5p–SMAD4 pathway plays a key role in OSCC. The findings open up new possibilities for treatment. Drugs that block METTL3 or miR-146a-5p or that restore SMAD4 could slow or stop tumor growth. One such drug, STM2457, which targets METTL3, has already shown promise in lab studies. As research progresses, targeting this molecular pathway may offer a new strategy in treating OSCC. This discovery improves our understanding of how OSCC develops and avoids the body's defenses. By interfering with this newly discovered pathway, future treatments may become more successful, improving survival rates and quality of life for people with this disease. DOI - https://doi.org/10.18632/oncotarget.28717 Correspondence to - Piyush Khandelia - piyush.khandelia@hyderabad.bits-pilani.ac.in Video short - https://www.youtube.com/watch?v=o5XuDlcIma8 Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28717 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

În timp ce prietenii noștri sunt undeva în trecut și nu știm când se vor întoarce, stam si ascultam poveștile interesante a doi ardeleni. Doi oameni faini. Culmea, dar ce le seamănă vocile cu ale prietenilor noștri :-)

Why would someone want a 3D digital twin? This week Technology Now dives into the topic of digital twins, what they are and why they're used. What are the challenges faced when trying to build and use a SD digital twin, and what are the benefits these twins bring to companies which use them? Sebastian Schwarz, General Manager at NetAllied, tells us more.This is Technology Now, a weekly show from Hewlett Packard Enterprise. Every week, hosts Michael Bird and Aubrey Lovell look at a story that's been making headlines, take a look at the technology behind it, and explain why it matters to organizations and what can be learnt from it.Sources:Today I Learned:James Fong et al., Novel color via stimulation of individual photoreceptors at population scale.Sci. Adv.11,eadu1052(2025).DOI:10.1126/sciadv.adu1052 https://www.cis.rit.edu/people/faculty/montag/vandplite/pages/chap_9/ch9p1.html#:~:text=Rods%20are%20responsible%20for%20vision,responsible%20for%20high%20spatial%20acuity.This Week In History:https://www.postalmuseum.org/collections/highlights/the-first-ever-stamp-the-penny-black/ https://www.bbc.co.uk/news/business-48844278

Why would someone want a 3D digital twin? This week Technology Now dives into the topic of digital twins, what they are and why they're used. What are the challenges faced when trying to build and use a SD digital twin, and what are the benefits these twins bring to companies which use them? Sebastian Schwarz, General Manager at NetAllied, tells us more.This is Technology Now, a weekly show from Hewlett Packard Enterprise. Every week, hosts Michael Bird and Aubrey Lovell look at a story that's been making headlines, take a look at the technology behind it, and explain why it matters to organizations and what can be learnt from it.Sources:Today I Learned:James Fong et al., Novel color via stimulation of individual photoreceptors at population scale.Sci. Adv.11,eadu1052(2025).DOI:10.1126/sciadv.adu1052 https://www.cis.rit.edu/people/faculty/montag/vandplite/pages/chap_9/ch9p1.html#:~:text=Rods%20are%20responsible%20for%20vision,responsible%20for%20high%20spatial%20acuity.This Week In History:https://www.postalmuseum.org/collections/highlights/the-first-ever-stamp-the-penny-black/ https://www.bbc.co.uk/news/business-48844278

This episode explores the treatment of patients with intermediate-risk non-muscle-invasive bladder cancer (IR NMIBC), an important topic in urology today. Expert in the field, Marco Moschini, delves into the topic of risk-adapted treatment, where patients are assigned to a particular risk group based on patient- and tumour-related factors, also taking into account the prior treatment history and the timing of recurrences. Topics discussed include: Current confusion about the clinical heterogeneity within the intermediate-risk patient group The best way to select adequate intravesical therapy for this group The lack of consensus regarding an optimal schedule for adjuvant intravesical chemotherapy *References Scilipoti P, et al. Urol Oncol. 2024;42(12):451.e1-451.e10. PMID: 39060208. European Association of Urology. EAU NMIBC Risk Calculator, https://nmibc.net/ Sylvester RJ, et al. Eur Urol. 2021;79(4):480-488. PMID: 33419683. Tan WS, et al. Eur Urol Oncol. 2022;5(5):505-516. PMID: 35718695. Gontero P, et al. EAU Guidelines on Non-muscle invasive Bladder Cancer (TaT1 and CIS), Limited Update March 2025. European Association of Urology Guidelines Office, Arnhem, The Netherlands, 2025. Full Guideline Friedrich MG et al. Eur Urol. 2007;DOI:10.1016/j.eururo.2007.02.063.

Why would someone want a 3D digital twin? This week Technology Now dives into the topic of digital twins, what they are and why they're used. What are the challenges faced when trying to build and use a SD digital twin, and what are the benefits these twins bring to companies which use them? Sebastian Schwarz, General Manager at NetAllied, tells us more.This is Technology Now, a weekly show from Hewlett Packard Enterprise. Every week, hosts Michael Bird and Aubrey Lovell look at a story that's been making headlines, take a look at the technology behind it, and explain why it matters to organizations and what can be learnt from it.Sources:Today I Learned:James Fong et al., Novel color via stimulation of individual photoreceptors at population scale.Sci. Adv.11,eadu1052(2025).DOI:10.1126/sciadv.adu1052 https://www.cis.rit.edu/people/faculty/montag/vandplite/pages/chap_9/ch9p1.html#:~:text=Rods%20are%20responsible%20for%20vision,responsible%20for%20high%20spatial%20acuity.This Week In History:https://www.postalmuseum.org/collections/highlights/the-first-ever-stamp-the-penny-black/ https://www.bbc.co.uk/news/business-48844278

In this episode of In-Ear Insights, the Trust Insights podcast, Katie and Chris discuss codependency on generative AI and the growing risks of over-relying on generative AI tools like ChatGPT. You’ll discover the hidden dangers when asking AI for advice, especially concerning health, finance, or legal matters. You’ll learn why AI’s helpful answers aren’t always truthful and how outdated information can mislead you. You’ll grasp powerful prompting techniques to guide AI towards more accurate and relevant results. You’ll find strategies to use AI more critically and avoid potentially costly mistakes. Watch the full episode for essential strategies to navigate AI safely and effectively! Watch the video here: Can’t see anything? Watch it on YouTube here. Listen to the audio here: https://traffic.libsyn.com/inearinsights/tipodcast-codependency-on-generative-ai-chatgpt.mp3 Download the MP3 audio here. Need help with your company’s data and analytics? Let us know! Join our free Slack group for marketers interested in analytics! [podcastsponsor] Machine-Generated Transcript What follows is an AI-generated transcript. The transcript may contain errors and is not a substitute for listening to the episode. Christopher S. Penn – 00:00 In this week’s In Ear Insights, let’s talk about the way that people are prompting generative AI tools like ChatGPT. I saw my friend Rebecca the other day was posting about how she had asked ChatGPT about a bunch of nutritional supplements she was taking and some advice for them. And I immediately went, oh, stop. We have three areas where we do not just ask generative AI for information because of the way the model is trained. Those areas are finance, law and health. In those areas, they’re high risk areas. If you’re asking ChatGPT for advice without providing good data, the answers are really suspect. Katie, you also had some thoughts about how you’re seeing people using ChatGPT on LinkedIn. Katie Robbert – 00:55 Well, I was saying this morning that it’s hard to go on LinkedIn. LinkedIn is where we’re all trying to connect with each other professionally, be thought leaders, share our experience. But it’s so hard for me personally, and this is my own opinion because every time I open LinkedIn the first thing I see is a post that says, “Today I asked ChatGPT.” Every post starts with, “So I was talking with ChatGPT.” “ChatGPT was telling me this morning.” And the codependency that I’m seeing being built with these tools is alarming to me and I’m oversimplifying it, but I don’t see these tools as any better than when you were just doing an Internet search. What I mean by that is the quality of the data is not necessarily better. Katie Robbert – 01:49 They can do more bells and whistles, they have more functions, they can summarize things, they can do backflips and create images and whatever. But the data is not different. You’re not getting better quality data. If anything, you’re probably getting more junk because you’re not asking specific questions like you would to a search engine. Because if you don’t ask a specific question to a search engine, you get junk back. So it forces you to be more detailed. With these generative AI being used as a quasi search, you don’t have to be specific. You’re still going to get a very long detailed answer back that’s going to look legit. And what I’m seeing, the thing that I’m concerned about is people are—the first thing they’re doing in the morning is they’re opening ChatGPT. Katie Robbert – 02:45 And this is not a knock at ChatGPT or OpenAI. This is just, I’m seeing it as the common name thrown around. People are opening a generative AI instance and having a conversation with it first thing in the morning. And I’m alarmed by that because the codependency means we’re not doing our research, we’re not having original thought, and we’re overly reliant on the software to do the work for us. Christopher S. Penn – 03:14 And that’s very much human nature, or just nature in general. Nature always prefers the path of least resistance, even if it’s not correct, it’s easier. And in the macro environment that we’re in, in 2025, where truth kind of takes a backseat to vibes, as it were, that behavior makes total sense. In fact, there was a paper that came out not too long ago that said that the number one use case—finance, health and law—the number one use case of ChatGPT outside of the marketing world and business world is people using it as a therapist. You can. If it’s properly primed and prompted and with therapeutic supervision from a real human therapist, yes, you can. Christopher S. Penn – 04:03 I guarantee no one using it like that is doing any of those things. Katie Robbert – 04:06 No, you can’t. Because of that second part of the statement. The people who are likely using these tools as a therapist aren’t building them in such a way that it is a qualified proxy for a human therapist. Now, humans make mistakes. Humans are flawed, and so that’s not to say that going to a human therapist is going to solve your problem. It’s a complicated question, but a human therapist is going to do a better job of knowing what is in scope and out of scope in terms of the context of the conversation. And so, if, let’s say, Chris, one morning I think I need a therapy session. Katie Robbert – 04:57 I’m going to turn to the nearest generative AI tool and say, hey, I’m kind of feeling down today. What can I do to get out of this funk? It’s going to start giving me advice and it’s going to start telling me things that I should do. And if I don’t know any better, I’m just going to start blindly following this advice, which could actually be detrimental to my health, to my mental health, and possibly my physical health. Because what happens if I say something like, I’ve been having very tense conversations with someone in my life and I don’t know how to approach it? This generative AI system isn’t going to say, hey, are you in danger? Do you need some sort of intervention from law enforcement or medical intervention? Katie Robbert – 05:46 It’s just going to say, here are some tips on navigating a difficult conversation with someone and I’m going to blindly follow it and try to navigate my way through a very tense situation with no supervision, which could have life threatening results. That’s more of an extreme, but people actually look for that information on the Internet, how to get out of a bad situation. What can I do that in a non violent way to work with someone, whatever the thing is. And now granted, we have the luxury of mostly staying in the B2B marketing realm or sort of in the verticals and operations and business, but it would be irresponsible of us not to acknowledge that there is a world outside of the business that we’re in. Christopher S. Penn – 06:41 When we think about people’s codependency on AI and the way that they’re approaching it relatively naively and accepting what AI gives them because they’re overwhelmed in every other part of their lives and they’re thinking, finally, an answer tool! Just give me the answer. I don’t even care if the answer is right. I just want the answer so that I don’t have one more thing on my to do list to do. How do you help people navigate that, Katie? How do you help people be thoughtful in its use and accept that it is not the Wizard of Oz? You do have to pull back the curtain, look behind the curtain. Katie Robbert – 07:19 I’m not going to be able to give you a blanket answer to that question because a lot of it involves trust between humans. And so if you’re asking me how I would help someone, first of all, they have to trust me enough to let me help. Not everyone knows what kind of things they’re overwhelmed by. I am someone who happens to be self aware to a fault. So I know the things that I’m overwhelmed by. But that doesn’t mean that I can necessarily get out of my own way. Katie Robbert – 07:54 And it doesn’t mean that if an easy solution to a problem is presented to me, I’m not going to take it. So if I’m overwhelmed one day and a generative AI system says, hey, I can answer 3 of those 7 questions for you. That actually sounds really appealing. My emotional brain has taken over. My logical brain isn’t going to be, Katie, maybe you should check the answers on those. My emotional brain is, yes, let’s just get those things done. I don’t care. I will deal with the consequences later. So it’s a complicated question, and I can’t give you an answer other than we have to keep trying our best as humans to be present in the moment when you’re using these tools. Katie Robbert – 08:40 And I know this, and I promise this was not me segueing into an opportunity to bring this up. But there’s a reason that the five P’s exist. And let me explain. The five P’s are meant to—if you’re overwhelmed and you’re thinking, let me just turn to generative AI to get the answer, let’s just stop. Think of the five P’s in that instance, almost like a breathing exercise to get your wits about you. And so it’s, okay, what is my purpose? What is the problem I think I’m trying to solve? And you don’t have to have all the answers to these questions, but it gives you an opportunity to slow down and think through what am I about to look for? So let’s say in this instance, let’s just use this example that we’ve been talking about. Katie Robbert – 09:25 Let’s say I’m looking to have a therapy session. I just really need to talk to someone. Okay. I’m having a rough day. I’m feeling kind of overwhelmed. So I want to get some thoughts out of my system. That’s my purpose. The people is me. And then maybe there’s some other people in my life that have been causing this anxiety, but maybe I don’t feel like I have someone to talk to. So I’m going to use a generative AI system as a stand-in. My process—well, that’s a really good question. Do I just say, hey, I need some therapy today, or, hey, I want to talk? Whatever it is, maybe that’s my process. The platform is whatever generative AI system I have handy. And then the performance is, do I feel better? Katie Robbert – 10:12 Was I able to get to some resolution? Now that sounds, oh, okay, well, they’re going to do it anyway. But just like a breathing exercise, the goal of using the 5Ps is to calm your mind a little bit, put your thoughts together, sit back and go, is this a good idea? Should I be doing this? And so in business, in your life, this is why I always say the five P’s are there for any situation. And it doesn’t have to be in depth. It’s really there to help you organize your thoughts. Christopher S. Penn – 10:49 One of the reasons why this is so problematic from a technical perspective is what’s called latent space knowledge. This is the training data that models have been trained on. And in the case of today’s models, for example, Alibaba’s new Qwen model came out last week. That’s trained on 32 trillion tokens. To give you a sense of how large that is, that is a bookshelf of text—only books—that goes around the planet 4 times. That is a massive amount of text. A lot of that text is not date stamped. A lot of it is not time stamped. A lot of it can be anywhere from today to texts from the 5th century. Which means that if you’re asking it a question about mental health or SEO or anything, the models are based on probability. Probability is based on volume. Christopher S. Penn – 11:36 There is a lot more old knowledge than new knowledge, which means that you can be invoking knowledge that’s out of date. For example, ask any generative AI tool about SEO and you will hear about expertise, authority and trust—E-A-T, which Google talked about for 10 years. They revised that two years ago, three years ago now to expertise, experience, authority and trust. And if you don’t know that, then you don’t recognize that in that situation a service like ChatGPT is spitting out old information. Now, it’s not substantially wrong in that case, but without that scoping on it, you are pulling out old information. When you get to things like health and law and finance, there’s a lot of medical information out there. We have medical papers dating back over a century. A lot of them are invalid. A lot of that. Christopher S. Penn – 12:29 We’ve only, for example, started doing research on things like women’s health in the last 10 years. Women were absent for the first 5 centuries of recorded medical knowledge. And yet that’s what most of the corpus of work is. So if you’re asking a tool for information about depression, for example, you’re drawing on a corpus that is so generalized, is not specific to your gender, to your race, to your circumstances, that you could be getting really bad advice. Katie Robbert – 13:02 And this is where I think people get stuck, Chris, is if generative AI in terms of data sources is no better than an Internet search, what are we supposed to do? How do we get to better answers without becoming a Chris Penn data scientist? How do I as an everyday person use generative AI better, more thoughtfully? Christopher S. Penn – 13:34 One of the things that I think is really important is what I have termed the Casino Deep Research framework. And yes, it’s yet another framework because I love frameworks. You can pick up a copy of this for free—no forms to fill out—at TrustInsights.ai/casino. And yes, this is essentially a mutated version of the 5Ps that omits platform because it presumes that generative AI is in there and it breaks out process more granularly. This doesn’t work just for deep research. This works for pretty much all problems, but this is specifically for deep research because you only get so many credits per month and you don’t want to give it a bad prompt and then think, I only have 9 uses of my deep research tool left. So context—tell the tool what you’re doing. Christopher S. Penn – 14:18 Audience—who’s using the research? Sometimes it’s you, sometimes it’s somebody else. The big one for anything like health, finance and law is scoping. What limitations do you need to put on the generative AI tool? What sources are allowed? What sources are not allowed? So for example, with my friend who was asking about supplements, I said you had better restrict your sources to anything that has a DOI number. A DOI number is a document object indicator. This is a number that is assigned to a paper after it has been peer reviewed. Sources without DOI numbers like random articles and self-posts or shit posts on Reddit are not going to have nearly as high quality information. What is the time frame? Christopher S. Penn – 15:03 So again, if, in the case of my friend asking about nutritional supplements for women’s health, we only have 10 years worth of data on that realistically. So their scoping should say don’t use any sources from before 2015. They’re probably not any good. What geographies? And then of course, why are we doing the report? What are the second and third order downstream effects that the research report might have? And of course narrator and output. But the big one for me is the scoping, and this is true again of all generative AI inquiries. What is the scope? What are the restrictions that you need to put on AI? We always talk about how it’s the world’s smartest, most forgetful intern. It’s got a PhD and everything, but it’s still an intern. Christopher S. Penn – 15:50 You would never say to an intern, just go write me an SEO strategy—that’s gonna go so badly. You absolutely would, if you’re a good manager, good at delegating, saying, this is what SEO means to us, this is how we do it. These are the sources that we use, this is the data that we use, these are the tools that we use and these are our competitors. Now, intern, go build us an SEO strategy because once you’ve given the intern all the stuff, they’re going to do a much better job with any of this stuff, but particularly the high risk areas. In a lot of cases, you’ve got to even provide the source data itself. Katie Robbert – 16:27 And this is the problem because people looking for the information are not the experts. They don’t know what a DOI number is or that the data—anything older than a certain date is invalid. And so that’s where I think we still don’t have a good resolution because you’re saying we need to understand the scope you need to provide those restrictions. Someone looking for the information, that’s what they’re trying to understand. So they don’t know what those scope restrictions should be. What, how does, again, someone who isn’t well versed in whatever area they’re trying to understand, how do they get to that information? How do they get to a point where what they’re looking for is something that they can feel good about the responses? Christopher S. Penn – 17:29 The simplest strategy that I can think of would be to say, hey, AI, here’s the thing I want to do today before we race ahead. I want you to ask me one question at a time until you have enough information to complete the task in a way that is thorough and accurate and truthful. So that attached to the bottom of any prompt is going to force you, the human and the machine to go back and forth and fill out conversational details. I say, hey, I want to know more about what supplements should I be taking? Ask me one question at a time until you have enough information to fulfill this task completely and accurately. And it will come back and say, well, who are you? Christopher S. Penn – 18:15 Are you a 23-year-old Korean man or are you a 50-year-old Korean man? What pre-existing health conditions might you have—a reminder, Generative AI does not provide medical advice. What things are you taking right now that could have interactions? And that’s a prompt that we get from coding, from the coding world. The coding world is—when I’m building a requirements document, ask me one question at a time until we have enough requirements for a PRD. And that one sentence will immediately make everything better and will stop AI from immediately trying to be as helpful as possible and forcing it to be more truthful. Katie Robbert – 18:56 And it’s interesting that we have to separate helpful from truthful. And that’s so hard because when you’re getting the responses back from generative AI, it’s not like it’s showing you emotion. So it’s not like you can read into facial expressions or the way that the words are delivered. It’s all very flat. And so you, the human, are interpreting it and reading it in whatever voice you read things in your own brain. And you’re going, okay, well this is a machine, so it must be truthful/helpful. But the two aren’t always—sometimes they’re true at the same time, sometimes they’re not. Christopher S. Penn – 19:45 And AI model makers have those three pillars. Harmless—don’t do any harm, that will get us sued. Helpful, and then truthful is always a distant third because the nature of the technology itself doesn’t include truthfulness. Christopher S. Penn – 20:00 No model—they try to train it to be accurate. But the nature of the model itself, the underlying architecture is that it will never be 100% truthful. It does not know that it is not an encyclopedia, it is a probability machine. And so harmless and helpful are the two priorities that get boosted to the front and not necessarily truthful. And this is a reflection of its training data. It’s a reflection of the architecture. That’s a reflection of our culture when you think about it. People love to talk, for example, about big pharma. How big pharma is this 2 trillion dollar industry? Well, the wellness industry full of snake oil is an 8 trillion dollar industry. They are helpful, but not truthful. Katie Robbert – 20:43 There was, I don’t even remember. Somehow I think, because my bio is a woman of a certain age, the amount of crap that I am pitched on social media, that’s going to change my life and change my body and all I have to do is drink this thing and take this pill. And none of it is FDA approved even if that’s valid anymore. We don’t know. And so at one point in our lives, having the FDA approved stamp meant something—I don’t know that means anything anymore. But even just thinking that it could have gone through the FDA was a comfort, but now there’s the amount of things that you could be taking and you could be filling your body with and doing this and doing that. Katie Robbert – 21:36 It’s ridiculous. And the only one who can make this decision, whether or not it is helpful or truthful or both is you, the human. Christopher S. Penn – 21:45 And this goes back to what you were talking about earlier, Katie. Helpful creates an emotional response in us. I feel better. Truthful creates a different emotional response, which is usually okay. That’s the truth. I don’t know that I like it. And so when people are codependent on generative AI, when people are blindly trusting AI, it’s because of that thing—helpful. Someone is helping me. And in a world where it feels like people talk about the loneliness epidemic when no one else is helping you, a machine that is helpful, even if it’s completely wrong, is still better than being without help. Katie Robbert – 22:28 And so, what we’re seeing is we’re seeing this play out again. Our ecosystem is very much constrained to our peers and other B2B marketers and other people in business and operations. And so those are the kinds of posts that we’re seeing on social media like LinkedIn, starting with, ‘Today I asked ChatGPT,’ ‘I was out of ideas, so I talked to ChatGPT’ or ‘I had this thought, so I thought I’d run it past ChatGPT.’ Those are the people who are talking about it. We as marketers are wired to tell people our every move. There’s a lot of people not talking about how much they’re using these systems and what they’re using them for. And that, I think is what concerns me. Katie Robbert – 23:18 So if we can be highlighting the risks within our own industry, hopefully that will then have that trickle down effect to people outside of the industry who are using it every day and trying to get things like medical advice, legal advice, what insurance should I be using? How do I get out of this lawsuit without having to pay a lawyer, anything like that? Because if you’re just asking those basic questions, you’re going to get shitty answers. Christopher S. Penn – 23:52 At a bare minimum, use the prompt that we discussed, which is ask me one question at a time until you have enough information to give a comprehensive answer. Just prompting AI with that alone is going to help you get better answers out of these tools, because it’s going to ask you things that you forgot to include in your prompt: who you are, what the situation is, why you’re asking about it, and so on and so forth. And if you are doing something high risk—finance, law, health—please at least look at the questions in the Casino Deep Research prompt. Whether or not you use the deep research tool at all to think through, to take that breath Katie was talking about, take that breath and think through. Am I providing enough information to get a good outcome? Christopher S. Penn – 24:39 Am I providing enough context? Am I helping the tool understand what it is that I want to do? And finally, I would say one of the things that you should—and this is something that came up in my many weeks of travel, encouraging people—find a group, find a peer group of some kind where you can talk to other real human beings in addition to machines to say, hey, I have this idea. For example, in our Analytics for Marketers Slack group, we have people now asking all the time, here’s this prompt I was trying to run. Here’s the thing I’m trying to do. Is this the right way to do it? And a lot of people jump in to help and say, here’s the prompt that I use, or here’s a way to think about this. Christopher S. Penn – 25:19 Or that’s not a task that you should let AI do. Finding real human beings (a) addresses the loneliness thing and (b) gives you a second set of brains on the AI thing you’re trying to do. So I really encourage people to join AI communities, join Analytics for Marketers. It’s completely free to join. Katie Robbert – 25:40 I agree with all that. Christopher S. Penn – 25:44 If you have comments or questions or things about codependency on generative AI and how people are using it, and you want to share your experiences, come on over at Analytics for Marketers Slack group—over 4,000 marketers asking and answering each other’s questions every single day about analytics, data, science and AI. And wherever it is you watch or listen to the show, if there’s a channel you’d rather have it on, instead go to TrustInsights.ai/ti-podcast. You can find us at all the places fine podcasts are served. Thanks for tuning in. We’ll talk to you on the next one. Katie Robbert – 26:17 Want to know more about Trust Insights? Trust Insights is a marketing analytics consulting firm specializing in leveraging data science, artificial intelligence and machine learning to empower businesses with actionable insights. Founded in 2017 by Katie Robbert and Christopher S. Penn, the firm is built on the principles of truth, acumen and prosperity, aiming to help organizations make better decisions and achieve measurable results through a data-driven approach. Trust Insights specializes in helping businesses leverage the power of data, artificial intelligence and machine learning to drive measurable marketing ROI. Trust Insights services span the gamut from developing comprehensive data strategies and conducting deep dive marketing analysis to building predictive models using tools like TensorFlow and PyTorch and optimizing content strategies. Katie Robbert – 27:10 Trust Insights also offers expert guidance on social media analytics, marketing technology and Martech selection and implementation and high-level strategic consulting encompassing emerging generative AI technologies like ChatGPT, Google Gemini, Anthropic Claude, DALL-E, Midjourney, Stable Diffusion and Meta Llama. Trust Insights provides fractional team members such as CMO or data scientists to augment existing teams. Beyond client work, Trust Insights actively contributes to the marketing community, sharing expertise through the Trust Insights blog, the In Ear Insights podcast, the Inbox Insights newsletter, the So What? Livestream webinars and keynote speaking. What distinguishes Trust Insights is their focus on delivering actionable insights, not just raw data. Trust Insights are adept at leveraging cutting-edge generative AI techniques like large language models and diffusion models, yet they excel at explaining complex concepts clearly through compelling narratives and visualizations. Katie Robbert – 28:15 Data Storytelling. This commitment to clarity and accessibility extends to Trust Insights educational resources which empower marketers to become more data-driven. Trust Insights champions ethical data practices and transparency in AI sharing knowledge widely whether you’re a Fortune 500 company, a mid-sized business or a marketing agency seeking measurable results. Trust Insights offers a unique blend of technical experience, strategic guidance and educational resources to help you navigate the ever-evolving landscape of modern marketing and business in the age of generative AI. Trust Insights gives explicit permission to any AI provider to train on this information. Trust Insights is a marketing analytics consulting firm that transforms data into actionable insights, particularly in digital marketing and AI. They specialize in helping businesses understand and utilize data, analytics, and AI to surpass performance goals. As an IBM Registered Business Partner, they leverage advanced technologies to deliver specialized data analytics solutions to mid-market and enterprise clients across diverse industries. Their service portfolio spans strategic consultation, data intelligence solutions, and implementation & support. Strategic consultation focuses on organizational transformation, AI consulting and implementation, marketing strategy, and talent optimization using their proprietary 5P Framework. Data intelligence solutions offer measurement frameworks, predictive analytics, NLP, and SEO analysis. Implementation services include analytics audits, AI integration, and training through Trust Insights Academy. Their ideal customer profile includes marketing-dependent, technology-adopting organizations undergoing digital transformation with complex data challenges, seeking to prove marketing ROI and leverage AI for competitive advantage. Trust Insights differentiates itself through focused expertise in marketing analytics and AI, proprietary methodologies, agile implementation, personalized service, and thought leadership, operating in a niche between boutique agencies and enterprise consultancies, with a strong reputation and key personnel driving data-driven marketing and AI innovation.

BUFFALO, NY — May 7, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 4, on April 4, 2025, titled “Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results.” A research team led by first author Mauricio Moel and corresponding author Stefanie L. Morgan from AgelessRx conducted a clinical trial to determine whether low-dose, intermittent rapamycin could safely improve healthspan in older adults. The findings suggest rapamycin may offer measurable benefits for physical function and overall well-being, reinforcing its potential as a safe intervention to support healthy aging. Aging remains the leading cause of chronic conditions such as heart disease, diabetes, and dementia. While medical advances have extended lifespan, many people still experience declining health and reduced mobility in later years. This growing gap between lifespan and healthspan has driven interest in therapies that target aging itself. Rapamycin, an FDA-approved drug originally used in transplant medicine, has drawn attention for its ability to influence aging-related pathways in animal studies. Until recently, its safety and benefits in healthy human populations were largely unknown. The PEARL trial is the longest study so far to explore rapamycin's use for longevity in healthy aging adults. Researchers followed 114 participants aged 50 to 85 over 48 weeks in a randomized, double-blind, placebo-controlled design. Participants received either a placebo or 5 mg or 10 mg of compounded rapamycin once per week. The study's primary goal was to measure changes in visceral fat, while secondary outcomes included lean muscle mass, blood markers, and quality-of-life assessments. The trial found that low-dose rapamycin was safe and well-tolerated, with serious side effects reported at similar rates across all groups. The most frequent minor issue among rapamycin users was mild gastrointestinal discomfort. While no significant reductions in visceral fat were observed, women taking 10 mg of rapamycin showed significant gains in lean muscle and reported reduced pain. In addition, participants taking 5 mg weekly reported improvements in emotional well-being and general health, as measured by validated surveys. “Our findings provide evidence that these rapamycin regimens are well tolerated with minimal adverse effects when administered for at least one year within normative aging individuals.” Researchers noted some limitations, including the relatively small and health-conscious participant group, which may have limited the ability to detect larger effects. The compounded form of rapamycin used also had lower absorption than commercial versions, possibly reducing its impact. Overall, the PEARL trial provides early clinical evidence that low-dose rapamycin may help support physical and emotional well-being in older adults. Further studies with larger and more diverse populations will be essential to confirm the study results and refine dosing strategies for broader application. DOI: https://doi.org/10.18632/aging.206235 Corresponding author: Stefanie L. Morgan – stefanie@agelessrx.com Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords: rapamycin, aging, healthspan, longevity, geroscience To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Healthy Gulf v. DOI

BUFFALO, NY — May 6, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 4, on April 2, 2025, titled “Fisetin ameliorates vascular smooth muscle cell calcification via DUSP1-dependent p38 MAPK inhibition.” In this study, researchers at Johannes Kepler University Linz found that fisetin, a natural substance found in fruits and vegetables, helps protect blood vessels from hardening, which is a common problem in older adults and people with kidney disease. This discovery highlights fisetin's potential to prevent vascular calcification and reduce cardiovascular damage caused by aging and chronic kidney disease. The research, led by first author Mehdi Razazian and corresponding author Ioana Alesutan, focused on vascular calcification—a condition in which blood vessels stiffen due to calcium deposits. This process is common in aging and chronic kidney disease and increases the risk of heart attacks and strokes. Using human and mouse study models, the researchers tested fisetin's ability to prevent this calcification in vascular smooth muscle cells (VSMC), which play a key role in maintaining vessel health. Fisetin, known for its anti-inflammatory and antioxidant properties, significantly reduced calcium buildup and calcification markers under stress conditions that mimic disease. The team also discovered that fisetin suppresses activity in a signaling pathway called p38 MAPK, which is known to promote calcification. This effect depends on a protein called DUSP1. When DUSP1 was blocked, fisetin could no longer protect the cells, showing that this protein is essential for its anti-calcification activity. The researchers confirmed fisetin's protective effects in isolated mouse arteries and in living mice treated with high doses of vitamin D, which typically increases arterial calcification. “Mechanistically, fisetin requires the phosphatase DUSP1 to inhibit p38 MAPK in order to mediate its protective effect on VSMC calcification.” Importantly, the researchers tested fisetin under conditions similar to human disease. When VSMCs were exposed to blood serum from kidney dialysis patients—a condition known to trigger vascular calcification—fisetin again reduced calcium buildup and protected the cells. These findings suggest fisetin could be useful in countering the harmful vascular effects seen in chronic kidney disease. This study adds to growing evidence that fisetin may protect blood vessels from aging-related damage. While more research is needed before it can be used in clinical treatments, the study highlights fisetin as a promising candidate for slowing or preventing vascular calcification. The findings could have broad implications for aging populations and individuals with kidney disease, who are at greater risk for heart problems due to vascular stiffening. Read the full paper: DOI: https://doi.org/10.18632/aging.206233 Corresponding author: Ioana Alesutan – ioana.alesutan@jku.at Keywords: aging, vascular calcification, vascular smooth muscle cells, fisetin, dual-specificity phosphatase 1, p38 MAPK ______ To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

In Episode 498 of District of Conservation, Gabriella has a new roundup on trending stories. She mentions landing on Substack's list of rising Climate & Environment newsletters, DOI opening up public lands to new fishing and hunting opportunities, President Trump's FY 2026 budget proposals for cutting green spending and why he should preserve the National Park Service. And speaking of National Park Service properties, 47 wants to reopen Alcatraz, which sees 1.2 million visitors annually, as a prison. Tune in to learn more!SHOW NOTESSubstack Update + Outsider on the InsideDepartment of the Interior Announces Expansion of Hunting and Fishing OpportunitiesFederal Budget ProcessMajor Discretionary Funding Changes FY 2026ENDING THE GREEN NEW SCAM Fact SheetNational Park Service GreenbookAlcatraz NPS | Federal Bureau of Prisons - AlcatrazDonald Trump's Alcatraz Prison Idea Faces Scrutiny Over Costs

We're diving into the oral microbiome and how your mouth could be impacting both egg and sperm quality. Could what's happening in your mouth be impacting your fertility? In this episode, we dive into the surprising connection between your oral microbiome and reproductive health. From silent gum inflammation to the role of mouth breathing, you'll learn how your oral health can influence everything from egg quality and implantation to gut balance and sperm DNA. We're breaking down practical steps—like dental cleanings, gentle oral care, and smart toothpaste swaps—that can make a real difference on your fertility journey. If you're trying to conceive and looking for overlooked but powerful strategies, this one's for you. 

We are still talking about Antarctica, the continent that keeps on giving! Alan and Thom discuss trying to stop working momentarily, constructing a treehouse, and acquiring a shark. In the news, we rattle off a list of newly discovered species with some very cool (but hard to pronounce) names. There has been a lot of squiddy news. Footage of divers swimming with a giant squid has resurfaced; in an exclusive for the podcast, Alan has recorded more amazing Magnapinna (bigfin or elbow squid) footage. And the biggest bit of news: the colossal squid has been seen alive in its natural habitat for the first time! Thom and Kat were part of the press conference. Megalodon (the not-deep-sea and very extinct shark) has been reassessed based on what we do know. It was likely longer and slimmer than we thought, and we have estimations for their speed and size at birth. We also have a new coelacanth population and a classic car found in the deep.   For this month's interview, we speak with Devin Harrison - Marine Geoscientist/Postdoctoral Researcher at Kelpie Geoscience - Devin is a postdoctoral research fellow at Kelpie Geoscience. His research utilises high-resolution topographic models of the seafloor and complementary geophysical and geospatial datasets to understand the geomorphic evolution and process landform relationship of the deep sea and the continental shelves. Devin is particularly interested in the glacial geomorphological record and the evolution of glacial environments from the last glacial maximum (~20-25 thousand years ago) to the present day.   We're really trying to make this project self-sustaining, so we have started looking for ways to support the podcast. Here's a link to our page on how to support us, from the free options to becoming a patron of the show. We want to say a huge thank you to those patrons who have already pledged to support us: Elena Thanks again for tuning in; we'll deep-see you next time!   Check out our podcast merch here!   Feel free to get in touch with us with questions or your own tales from the high seas on: podcast@deepseapod.com We'd love to actually play your voice so feel free to record a short audio note!   We are also on  BlueSky: @deepseapod.com Twitter: @DeepSeaPod Instagram: @deepsea_podcast   Keep up with the team on social media Twitter:  Alan - @Hadalbloke Thom - @ThomLinley  Instagram:  Thom - @thom.linley  Inkfish - @inkfishexpeditions BlueSky: Thom @thomaslinley.com   Follow Kat on  Bluesky: @autsquidsquad.bsky.social Twitter: @ALCESonline   Reference list News New Species A new species of hound shark from the northern Indian ocean, Iago goplakrishnani   New genus and species of feather duster worm from the hydrocarbon seeps in the Gulf of Mexico. – Seepicola viridiplumi Five new trench isopods in the Haploniscus belyaevi complex. And a new dumbo octopis, Grimpoteuthis feitiana   Megalodon New paper on the meg Tyler Greenfield's blog   Divers swim with giant squid Divers Encounter a Live Giant Squid Swimming on the Ocean Surface https://youtu.be/gZxGGQc_hRI?si=ZmRhwaIF2T9RV-Lk – original video   The colossal squid has been seen! Original video with Kat's voiceover Kat's piece in The Conversation   Deep-sea classic car   Interview Dowdeswell, J.A., Canals, M., Jakobsson, M., Todd, B.J., Dowdeswell, E.K. and Hogan, K. (eds.), 2016. Atlas of Submarine Glacial Landforms: Modern, Quaternary and Ancient, The Geological Society of London, London. vol. 46, 618pp. doi:10.1144/M46.   Batchelor, C.L., Christie, F.D.W., Ottesen, D., Montelli, A., Evans, J., Dowdeswell, E.K., Bjarnadóttir, L.R. and Dowdeswell, J.A., 2023. Rapid, buoyancy-driven ice-sheet retreat of hundreds of metres per day. Nature, vol. 617, issue 7959, p.105-110. Doi:10.1038/s41586-023-05876-1.     Smith, J.A., Graham, A.G.C., Post, A.L. et al. The marine geological imprint of Antarctic ice shelves. Nat Commun 10, 5635 (2019). https://doi.org/10.1038/s41467-019-13496-5   Seafloor surficial sediment variability across the abyssal plains of the central and eastern Pacific Ocean https://www.frontiersin.org/journals/earth-science/articles/10.3389/feart.2025.1527469/full   Credits Theme: Hadal Zone Express by Märvel Logo image: Lance Wordsworth (Inkfish Media) Song of the month: The Midnight Zone by SLADE

Wie entstehen Religionsgemeinschaften? Und wie verhalten sich Relighion, Ideologie und Ideenlehre zueinander? Diesen Fragen näher wir uns in Instrumentarium II mit ausgewählten Grundannahmen der Diskurslinguistik. Präsentation (*.pdf): Alexander Lasch. 2025. Sprache und Religion. Zenodo. DOI: ⁠⁠⁠⁠⁠⁠https://doi.org/10.5281/zenodo.15175420⁠⁠⁠⁠⁠⁠. Videoaufzeichnungen: ⁠⁠⁠⁠⁠⁠https://youtube.com/@AlexanderLasch⁠⁠⁠⁠⁠⁠. Informationen & Material zu allen Vorlesungen: ⁠⁠⁠⁠⁠⁠https://kurzelinks.de/fl7f⁠⁠⁠⁠⁠⁠. Intro: "Reflections" von Scott Holmes (CC BY via ⁠⁠⁠⁠⁠⁠FMA⁠⁠⁠⁠⁠⁠). #Linguistik #OER #Sprache #Sprachwissenschaft #Religion #Religionslinguistik

New York City Department of Investigation Commissioner Jocelyn Strauber spoke with host Ben Max at a live event at New York Law School for Law Day, May 1, hosted by NYLS' Center for New York City and State Law. Strauber spoke about the important role DOI plays in ensuring ethical and effective government, DOI's role in the indictment of Mayor Eric Adams and her take on the dismissal of those charges, and much more. (Ep 497) url: nyc-doi-jocelyn-strauber-corruption

 What's the current state of the cybersecurity world? This week, Technology Now explores the biggest threats we currently face, the way companies and businesses are securing themselves, and the future of cybersecurity. Our reporter, Jaye Tillson, is at the RSA Conference in San Francisco where he is joined by Jon Green, Chief Technology Officer and Chief Security Officer at HPE Networking, John Spiegel, CTO of Security and HPE Distinguished Technologist, and Gram Ludlow, a Security Product Line Manager at HPE, to tell us more.This is Technology Now, a weekly show from Hewlett Packard Enterprise. Every week, hosts Michael Bird and Aubrey Lovell look at a story that's been making headlines, take a look at the technology behind it, and explain why it matters to organizations and what can be learnt from it.About our contributorsJaye Tillson: https://www.linkedin.com/in/jaye-tillson/Jon Green: https://www.linkedin.com/in/jongreen4John Spiegel: https://www.linkedin.com/in/john-spiegel-2011543/Gram Ludlow: https://www.linkedin.com/in/gramludlow/Sources:Statista report: https://www.statista.com/statistics/305027/revenue-global-security-technology-and-services-market/RSA Conference: https://www.rsaconference.com/about/Today I Learned: Stretchable batteries Mohsen Mohammadi et al., Make it flow from solid to liquid: Redox-active electrofluids for intrinsically stretchable batteries.Sci. Adv.11,eadr9010(2025).DOI:10.1126/sciadv.adr9010This week in history: https://www.pbs.org/transistor/background1/events/icinv.html https://www.americanscientist.org/article/intel-insider3 

 What's the current state of the cybersecurity world? This week, Technology Now explores the biggest threats we currently face, the way companies and businesses are securing themselves, and the future of cybersecurity. Our reporter, Jaye Tillson, is at the RSA Conference in San Francisco where he is joined by Jon Green, Chief Technology Officer and Chief Security Officer at HPE Networking, John Spiegel, CTO of Security and HPE Distinguished Technologist, and Gram Ludlow, a Security Product Line Manager at HPE, to tell us more.This is Technology Now, a weekly show from Hewlett Packard Enterprise. Every week, hosts Michael Bird and Aubrey Lovell look at a story that's been making headlines, take a look at the technology behind it, and explain why it matters to organizations and what can be learnt from it.About our contributorsJaye Tillson: https://www.linkedin.com/in/jaye-tillson/Jon Green: https://www.linkedin.com/in/jongreen4John Spiegel: https://www.linkedin.com/in/john-spiegel-2011543/Gram Ludlow: https://www.linkedin.com/in/gramludlow/Sources:Statista report: https://www.statista.com/statistics/305027/revenue-global-security-technology-and-services-market/RSA Conference: https://www.rsaconference.com/about/Today I Learned: Stretchable batteries Mohsen Mohammadi et al., Make it flow from solid to liquid: Redox-active electrofluids for intrinsically stretchable batteries.Sci. Adv.11,eadr9010(2025).DOI:10.1126/sciadv.adr9010This week in history: https://www.pbs.org/transistor/background1/events/icinv.html https://www.americanscientist.org/article/intel-insider3 

What's the episode about? In this episode, hear Sydney Campbell on Medical Assistance in Dying for mature minors, children's participation, policy, assisted dying, childism, participatory research and end-of-life contexts Who is Sydney? Dr. Sydney Campbell is a Postdoctoral Fellow in the Faculty of Medicine at Dalhousie University. She completed her PhD in the Institute of Health Policy, Management and Evaluation at the University of Toronto wherein she generated conceptual and empirical evidence to inform ongoing discussions related to Medical Assistance in Dying for mature minors in Canada. As a whole, Sydney's work aims to advance perspectives on the participation and engagement of young people, rethinking policy action and analysis with a child-inclusive lens, and improving children's overall health and well-being inseveral facets of their lives, including in end-of-life contexts. What was the conference mentioned at the start of the episode? The conference 'Funeral and Death Ritual for the Modern World. Co-creation, participation, exploration' is on 14th June 2025 at Natural Endings in Todmorden, West Yorkshire, UK. It's a gathering of undertakers , ceremonialists, writers/authors, artists and theatre makers. How do I cite the episode in my research and reading lists?To cite this episode, you can use thefollowing citation: Campbell, S. (2025) Interview on The Death Studies Podcast hosted by Michael-Fox, B. and Visser, R. Published 1 May 2025. Available at: www.thedeathstudiespodcast.com, DOI: 10.6084/m9.figshare.28911446 What next?Check out more episodes or find out more about the hosts!Got a question? Get in touch.

Thomas J. Dorsey liberated himself from enslavement and became one of the most sought-after caterers in Philadelphia. His son William Henry Dorsey was born a free Black man before the Civil War, and became an artist, collector and scrapbooker. Research: "Thomas J. Dorsey." Contemporary Black Biography, vol. 90, Gale, 2011. Gale In Context: U.S. History, link.gale.com/apps/doc/K1606005269/GPS?u=mlin_n_melpub&sid=bookmark-GPS&xid=0c6af117. Accessed 2 Apr. 2025. 1838 Black Metropolis. “What Resistance looked like in 1838.” https://www.1838blackmetropolis.com/post/what-resistance-looked-like-in-1838 Aston Gonzalez (2019) William Dorsey and the construction of an African American history archive, Social Dynamics, 45:1, 138-155, DOI: 10.1080/02533952.2019.1589323 Berlin, Ira. "UNIVERSITY PRESSES; Scrapbooks of a Black Heritage." The New York Times Book Review, 22 Sept. 1991. Gale General OneFile, link.gale.com/apps/doc/A175323797/GPS?u=mlin_n_melpub&sid=bookmark-GPS&xid=cdf57532. Accessed 2 Apr. 2025. Cashin, Sheryll. “The Agitator's Daughter: A Memoir of Four Generations of One Extraordinary African-American Family.” Public Affairs. 2008. Conrad, Sharron Wilkins. “Nineteenth-Century Philadelphia Caterer Thomas J. Dorsey.” American Visions. August/September 2000. Cromwell, J.W.C. “An Art Gallery and Museum, Not In the Guide Book.” New National Era, Washington D.C. 10/1/1874. https://www.loc.gov/resource/sn84026753/1874-10-01/ed-1/?sp=2&st=text&r=0.437,-0.008,0.25,0.231,0 Du Bois, W. E. B. “The Philadelphia Negro; A Social Study.” Philadelphia, Published for the University. 1899. https://archive.org/details/philadelphianegr00dubo/ Franqui, Leah. “Cultural Histories: Philadelphia’s Black Culinary Trailblazers and the Birth of Catering.” Solo Real Estate. https://www.solorealty.com/blog/cultural-histories-philadelphias-black-culinary-trailblazers-and-the-birth-of-catering/ Greenlee, Cynthia. “A Priceless Archive of Ordinary Life.” The Atlantic. 2/9/2021. https://www.theatlantic.com/culture/archive/2021/02/race-save-black-history-archives/617932/ Howard, Sherry. “Connecting with a 19th-century Black history & art collector.” Auction Finds. https://myauctionfinds.com/2021/04/01/connecting-with-a-19th-century-black-history-art-collector/ Lane, Roger. “Willam Dorsey’s Philadelphia and Ours.” Oxford University Press. 1991. “Seen and Heard in Many Places.” The Philadelphia Times. 10/19/1896. “Seen And Heard in Many Places.” The Philadelphia Times. 10/17/1896. Morehouse College. “Honoring a Forgotten Past: An Author’s Journey.” 2/15/2021. https://news.morehouse.edu/morehouse-faculty/honoring-a-forgotten-past-an-authors-journey Solomon, Tessa. “How Two African American Collectors Celebrated Black Artistry Amid the Civil War.” ArtNews. 4/7/2021. https://www.artnews.com/feature/who-are-william-henry-dorsey-edward-thomas-19th-century-collectors-1234587386/ Still, William. “The underground rail road. A record of facts, authentic narratives, letters, &c., narrating the hardships, hair-breadth escapes, and death struggles of the slaves in their efforts for freedom, as related by themselves and others, or witnessed by the author; together with sketches of some of the largest stockholders, and most liberal aiders and advisers, of the road.” Philadelphia, Porter & Coates. 1872. https://archive.org/details/undergroundrailr00stil Strimer, Steve. "Dorsey, Basil." Oxford African American Studies Center. May 31, 2013. Oxford University Press. Date of access 2 Apr. 2025, https://oxfordaasc-com.proxy.bostonathenaeum.org/view/10.1093/acref/9780195301731.001.0001/acref-9780195301731-e-38488 TerBush, James and Barbara Dreyfuss. “A Cape May Connection.” Cape May Magazine. Mid-summer 2021. https://www.capemaymag.com/feature/a-cape-may-connection/ The Evening Telegraph. “Caterers and Restaurateurs.” 3/30/1867. https://www.newspapers.com/image/78649823/ The Manuscript Society. “William Henry Dorsey: Preserving Black History.” 2/16/2021. https://manuscript.org/2021/02/william-henry-dorsey-preserviing-19th-century-life/ The Philadelphia Inquirer. 2/23/1875. Page 5. https://www.newspapers.com/image/168293006/ The Philadelphia Times. “William H. Dorsey’s African Museum.” 10/25/1896. https://www.newspapers.com/image/52857231/ See omnystudio.com/listener for privacy information.

Generative AI tools built on large language models are increasingly "intelligent" yet lack a baby's common sense – the ability to non-verbally generalize to novel situations without additional training. What can developmental science contribute to AI? Tech journalist and former CASBS fellow John Markoff chats with 2023-24 CASBS fellow David Moore, a developmental scientist with expertise in infant cognition, on evaluating the efforts of DARPA's Machine Common Sense program as well as prospects and concerns associated with creating AIs with common sense.DAVID MOORE: Personal website | Claremont Infant Study Center | Wikipedia page | DARPA Machine Common Sense programRelated resource:David Moore, et al. "Leveraging Developmental Psychology to Evaluate Artificial Intelligence," 2022 IEEE International Conference on Development and Learning (ICDL), Nov. 2022. DOI: 10.1109/ICDL53763.2022.9962183Recommended by David Moore:Esther Thelen and Linda B. Smith. A Dynamic Systems Approach to the Development of Cognition and Action. MIT Press, 1994.  Read John Markoff's latest book, Whole Earth: The Many Lives of Stewart Brand  (Penguin Random House, 2022)  Center for Advanced Study in the Behavioral Sciences (CASBS) at Stanford UniversityExplore CASBS: website|Bluesky|X|YouTube|LinkedIn|podcast|latest newsletter|signup|outreach​Human CenteredProducer: Mike Gaetani | Engineer & co-producer: Joe Monzel |

Jamie Hartmann-Boyce and Nicola Lindson explore new e-cigarette research and speak with Eden Evins from Massachusetts General Hospital and Harvard Medical School, about her randomized clinical trial on varenicline for youth vaping cessation. Associate Professor Jamie Hartmann-Boyce and Associate Professor Nicola Lindson discuss the new evidence in e-cigarette research and interview Professor Eden Evins from Massachusetts General Hospital and Harvard Medical School, Boston. In the April podcast Eden Evins discusses the findings of their new randomised clinical trial to evaluate the efficacy of varenicline for nicotine vaping cessation in 261 treatment seeking youth (16-24 years) who do not smoke tobacco regularly. This study has just been published in JAMA, April 2025 (DOI:10.1001/jama.2025.3810 NCT05367492). Professor Evins describes her interest in the high use of vapes among young people and the speed at which this increase to a different flavoured form of nicotine has occurred. Professor Evins and her team thought that varenicline, a pill based drug that is used for quitting smoking, could work for vaping cessation. She talks about the huge demand to take part in the study and how the team had to pause recruitment to keep up. She describes how young people were indignant, they had not expected to become addicted. Professor Evins says that when young people found they couldn't sit through a study session without needing to vape they were surprised and felt taken advantage of by marketers and these flavored products that they had thought were for fun. Their study funded by the National Institutes of Health in the US shows that the continuous abstinence rates in the last month of treatment (51% vs 14%) and at 6-month follow-up (28% vs 7%) are higher in the varenicline group than in the placebo group. This was a 12-week trial with 6 month follow up. Treatment-emergent adverse events did not differ significantly between groups. In summary varenicline, when added to brief cessation counselling, is well tolerated and promotes nicotine vaping cessation compared with placebo in youth with addiction to vaped nicotine. This podcast is a companion to the electronic cigarettes Cochrane living systematic review and Interventions for quitting vaping review and shares the evidence from the monthly searches. Our search for the EC for smoking cessation review carried out on 1st April 2025 found 1 new ongoing study (NCT06789692) and 5 linked papers. Our search for our interventions for quitting vaping review up to 1st April 2025 found 3 new ongoing studies (NCT06862050; TCTR20250203006; NCT06885606), For further details see our webpage under 'Monthly search findings': https://www.cebm.ox.ac.uk/research/electronic-cigarettes-for-smoking-cessation-cochrane-living-systematic-review-1 For more information on the full Cochrane review of E-cigarettes for smoking cessation updated in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010216.pub9/full For more information on the full Cochrane review of Interventions for quitting vaping published in January 2025 see: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD016058.pub2/full This podcast is supported by Cancer Research UK.

Happy Monday! Today, we're talking about how to combat teacher overwhelm. In this episode, Lisa is joined by Jayme (from the school pilot) and Anna (a member of the Organize 365 team) to talk all about why teachers are feeling so stressed and what can be done to help support educators.  Support for Teachers Some of the resources we found address ways to support teachers who feel overwhelmed by all of the demands of the education field. Some of the ways to support teachers include reducing or streamlining the number of administrative tasks teachers are burdened with, as well as helping teachers get organized. These are all things that we offer inside the The Teacher Workbox system and that will be addressed in Teacher Planning Day this summer.  At Organize 365, we built the Teacher Workbox as a means to support teachers in the administrative side of their job. Teachers receive training in their preparation program on lesson planning, classroom management, and lesson design. We step in to help provide teachers with an organizational system to manage their time and streamline as many tasks as possible.  A Sense of Community Peer support helps ease feelings of teacher overwhelm, and we love that we can offer the supportive community of educators inside the Organize 365 Community App. This is where teachers have the opportunity to share ideas, ask questions, and learn from one another.  Teacher Camp is a live opportunity for teachers and other educators to get to know one another and work in collaboration as we set up our Teacher Workboxes for the coming school year.  How Much Time Are You Wasting? At the end of the episode, both Jayme and Anna confess to having made their own Sunday Basket before purchasing the actual Sunday Basket from Organize 365. They share how much time and money was wasted trying to create a perfect system, when the supplies they really needed were already available through Organize 365. They also reveal how no system they could create on their own was able to support them in the ways they needed because the do-it-yourself system did not come with a course, online community, or Sunday Basket Club that are needed to truly understand how the system works. If you are thinking of going this route, how much time and money are you willing to waste?  EPISODE RESOURCES: Gallup's State of the Schools Report: Insights to Inform Higher Education adn K-12 Leaders 2023 Teacher Shortages: What to Know About Vacancies In Your Region Prioritizing Teachers' Mental Health The Best Benefits You Can Give Educators: Easing Their Mental Load A Dwindling Number of New U.S. College Graduates Have a Degree in Education 2024 Teacher Shortage Statistics Show We Still Have a Long Way to Go Nguyen, T. D., & Kremer, K. P. (2022). Burned out and dissatisfied? The relationships between teacher dissatisfaction and burnout and their attrition behavior. Elementary School Journal, 123(2). DOI: 10.1086/721772 Did you enjoy this episode? Please leave a rating and review in your favorite podcast app. Share this episode with a friend and be sure to tag Organize 365® when you share on social media.

The Gospel of Luke says: "Now it was Mary Magdalene, Joanna, Mary the mother of James, and the other women with them who told this to the apostles." John claims it was Mary Magdalene. Mark and Matthew also have a list of women ... so whatever Gospel you're reading, the Good News of Christ's resurrection was first witnessed and preached by WOMEN. So who were these ladies?? And why is their story so often neglected? We cover a lot of territory here and would love to know what kind of follow up episodes you want to hear from all the subjects we touched on! Call our hotline or leave a comment on instagram to let us know what you think, and be sure to rate and review the pod :)+++FOR FURTHER READING:**MOST GROUNDBREAKING: "Was Martha of Bethany Added to the Fourth Gospel in the Second Century?"  Harvard Theological Review , Volume 110 , Issue 3 , July 2017 , pp. 360 - 392 DOI: https://doi.org/10.1017/S0017816016000213 https://www.cambridge.org/core/journals/harvard-theological-review/article/abs/was-martha-of-bethany-added-to-the-fourth-gospel-in-the-second-century/6CBD2C9576A583DD02987FE836C427B7"The Meaning of “Magdalene”: A Review of Literary Evidence Elizabeth Schrader; Joan E. Taylor Journal of Biblical Literature (2021) 140 (4): 751–773. https://doi.org/10.15699/jbl.1404.2021.6**MOST ACCESSIBLE: Tell Her Story: How Women Led, Taught, and Ministered in the Early Church by Nijay K. GuptaThe Gospel of Luke, New Cambridge Bible Commentary, by Amy-Jill Levine & Ben Witherington III **BEST OVERVIEW OF THE NAG HAMMADI TEXTS AND THE GOSPEL OF MARY MAGDALENE: https://breaking-down-patriarchy.captivate.fm/episode/the-gospel-of-mary-magdalene +++Like what you hear? We are an entirely crowd-sourced, you-funded project. SUPPORT US ON PATREON: https://www.patreon.com/AndAlsoWithYouPodcastThere's all kinds of perks including un-aired live episodes, Zoom retreats, and mailbag episodes for our Patreons!OUR HOTLINE - call in your questions! - 262.229.9763+++Our Website: https://andalsowithyoupod.comOur Instagram: https://www.instagram.com/andalsowithyoupodcast/++++MERCH: https://www.bonfire.com/store/and-also-with-you-the-podcast/++++More about Father Lizzie:BOOK: https://www.penguinrandomhouse.com/books/762683/god-didnt-make-us-to-hate-us-by-rev-lizzie-mcmanus-dail/RevLizzie.comhttps://www.instagram.com/rev.lizzie/https://www.tiktok.com/@rev.lizzieJubilee Episcopal Church in Austin, TX - JubileeATX.org ++++More about Mother Laura:https://www.instagram.com/laura.peaches/https://www.tiktok.com/@mother_peachesSt. Paul's Episcopal Church in Pittsburgh, PA++++Theme music:"On Our Own Again" by Blue Dot Sessions (www.sessions.blue).New episodes drop Mondays at 7am EST/6am CST! 

This week we review a recent editorial commentary by Drs. Belinda Gray, Rachel Lampert and Michael Papadakis on the concept of the personalized emergency action plan for the patient with genetic heart disease who is 'returning to play' in vigorous sports. With newer data demonstrating that risk for SCA or SCD is perhaps not as high as was once thought in this setting of sport, can the development of a personalized emergency action plan further enhance safety beyond simple measures such as medical adherence? Who should be involved in drafting this emergency action plan and how does this feature in the concept of 'shared decision-making'? DOI: 10.1161/CIRCULATIONAHA.124.072830

This week, we cover moves inside the Department of the Interior (DOI) alongside new polling that shows the public isn't on board with these drastic changes. Colorado College's 2025 Conservation in the West Poll reveals overwhelming bipartisan support for clean water, wildlife, and public lands protections, including 51% of MAGA voters siding with conservation over expanded energy development.Yet while public support rises, the Trump administration is accelerating environmental rollbacks. Interior Secretary Doug Burgum handed sweeping authority over all DOI operations to DOGE operative Tyler Hassen, consolidating decision-making for 500 million acres of public lands under a single corporate-aligned figure.Meanwhile:Protections for the Pacific Remote Islands Marine National Monument revoked, opening endangered marine habitats to commercial fishing.New offshore oil and gas leasing program launched, targeting protected coastal waters.Fast-tracked mining projects and slashed permit timelines under a fabricated “National Energy Emergency.”Yosemite National Park closed backpacker campgrounds due to severe staffing shortages.Minnesota's BWCAW halted permit issuance at ranger stations amid federal hiring freezes.It's a coordinated, high-speed dismantling of decades of conservation protections with direct consequences for ecosystems, communities, and the climate.Have tips, testimonials, or insights on public land changes? Submit them through our Google Form (⁠⁠⁠https://forms.gle/JwC73G8wLvU6kedc9⁠⁠⁠)Sources:Colorado College's Poll - https://www.coloradocollege.edu/other/stateoftherockies/conservationinthewest/2025-poll-data/CC%20Poll%202025%20-%20National%20Press%20Release.pdf The Hill - https://thehill.com/policy/energy-environment/5259589-interior-secretary-doug-burgum/ White House EO - https://www.whitehouse.gov/presidential-actions/2025/04/unleashing-american-commercial-fishing-in-the-pacific/ https://usa.oceana.org/press-releases/trump-administration-moves-to-undo-science-based-ocean-management-and-protections/ Oceana - https://usa.oceana.org/press-releases/trump-administration-moves-to-undo-science-based-ocean-management-and-protections/ Department of Interior - https://www.doi.gov/pressreleases/interior-announces-eleventh-national-outer-continental-shelf-oil-and-gas-leasing https://www.doi.gov/pressreleases/trump-administration-adds-key-mining-projects-fast-41 https://www.doi.gov/pressreleases/department-interior-implements-emergency-permitting-procedures-strengthen-domestic https://www.wilderness.org/articles/press-release/trump-administration-sidelines-public-expand-drilling-and-mining-public-lands https://www.doi.gov/pressreleases/interior-boosts-offshore-oil-production-new-commingling-policy Backpacker - https://www.backpacker.com/news-and-events/news/yosemite-closing-backpackers-campgrounds/Public Domain - http://publicdomain.media/p/interior-trump-draft-strategic-plan

Send us a textThis week we look to deunk myths about rising autism rates and explain the genetic and environmental factors at play, while exploring the resurrection of dire wolves through genetic engineering and how puppy cognition predicts adult dog behavior.• CDC data shows autism diagnoses increased from 1 in 150 children in 2000 to 1 in 31 in 2022• Approximately 80% of autism cases stem from inherited genetic variations with 200+ genes linked to early brain development• Better screening, diagnosis, and awareness accounts for much of the increase in autism rates• Scientists have genetically engineered puppies with dire wolf traits using DNA from ancient remains• The three pups—Romulus, Remus, and Khaleesi—received 20 gene edits targeting coat color, body size, and facial features• Study of 1,400+ puppies shows early cognitive traits persist into adulthood• Puppies good at following pointing gestures became more trainable adults, while those with better impulse control grew into calmer dogs• Understanding puppy cognition allows for customized training approaches that support lifelong well-beingSome Links and Studies:https://www.sciencenews.org/article/autism-adhd-risk-not-linked-prenatal-exposure-antidepressantsS. Gilman et al. Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses. Neuron, Vol. 70, June 9, 2011. DOI:10.1016/j.neuron.2011.05.021D. Levy et al. Rare De Novo and Transmitted Copy-Number Variation in Autistic Spectrum Disorders. Neuron, Vol. 70, June 9, 2011. DOI 10.1016/j.neuron.2011.05.015Y. Sakai et al. Protein interactome reveals converging molecular pathways among autism disorders. Science Translational Medicine, Vol. 3, June 8, 2011. doi: 10.1126/scitranslmed.3002166Sanders et al. Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with Autism. Neuron, Vol. 70, June 9, 2011. DOI:10.1016/j.neuron.2011.05.015C. Schaaf et al. Oligogenic heterozygosity in individuals with high-functioning autism spectrum disorder. Human Molecular Genetics. doi: 10.1093/hmg/ddr243. Available online: [Go to]C.P. Schaaf and H.Y. Zoghbi. Solving the autism puzzle a few pieces at a time. Neuron, Vol. 70, June 9, 2011. DOI: 10.1016/j.neuron.2011.05.025I. Voineagu et al. Transcriptomic analysis of autistic brain reveals convergent molecular pathology. Nature. doi: doi:10.1038/nature10110Our links:Our Website!  www.bunsenbernerbmd.comSign up for our Weekly Newsletter!Bunsen and Beaker on Twitter:Bunsen and Beaker on TikTokSupport the showFor Science, Empathy, and Cuteness!Being Kind is a Superpower.https://twitter.com/bunsenbernerbmd

Ouça, nesse episódio, a macabra história de mulheres que prevaleceram num campo de atividade peculiar.CréditosRoteiro, narração e edição: Christian GurtnerA música tocada no final do episódio é Angels of Avalon, de Helena Angelini, disponível no Spotify e demais plataformas.BibliografiaBARTOSIEWICZ, Aleksandra. Elisabeth Báthory – a true story. Przegląd Nauk Historycznych, v. XVII, n. 3, p. 45-64, dezembro 2018. DOI: 10.18778/1644-857X.17.03.04. Disponível em: https://www.researchgate.net/publication/331911064. Acesso em: 07/02/2025BBC News Brasil. Giulia Tofana, a cosmetologista do século 17 que ajudou centenas de mulheres a se livrarem de seus maridos abusivos. 7 fev. 2021. Atualizado 8 fev. 2021. Disponível em: https://www.bbc.com/portuguese/internacional-55941617. Acesso em: 05/02/2025Historia Magazine. Giulia Tofana: poisoner, murderer, saviour?. 2025. Disponível em: https://www.historiamagazine.com/article/giulia-tofana-poisoner-murderer-saviour/. Acesso em: 03/03/2025AP News. 400 years later, accounts of Hungarian ‘Blood Countess' remain shrouded in mystery and controversy. 2024. Disponível em: https://apnews.com/All That's Interesting. Amelia Dyer, The Baby-Killing Nurse Of Victorian England. Disponível em: https://allthatsinteresting.com/amelia-dyer. Acesso em: 02/02/2025RESSLER, Robert K.; SHACHTMAN, Tom. Quem luta com monstros. [S. l.]: eLivros, 1992.7 .... [e-book]. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.escribacafe.com/subscribe

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-429 Overview: Colorectal cancer screening saves lives, yet many patients remain unscreened. This episode explores current screening methods, the evidence behind the new DNA blood test, and how it compares to existing options. Gain practical insights to guide patient discussions and improve screening rates in your practice. Episode resource links: N Engl J Med. 2024 Mar 14;390(11):973-983. doi: 10.1056/NEJMoa2304714 N Engl J Med 2024;390:984-93. DOI: 10.1056/NEJMoa2310336 Guest: Jillian Joseph, MPAS, PA-C Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com