Podcasts about DOI

This week we review a recent report on LV strain following the Ross operation. Can this sort of functional analysis help predict remodeling after aortic valve replacement? How can the type of Ross potentially affect heart function after the operation? Why might some parameters of LV strain improve but others not following surgery? Can preoperative strain measurements predict perioperative course? How does the addition of a Konno to a Ross change the outcomes of function? We speak with Chief of Cardiovascular Surgery at Primary Children's Hospital in Utah, Dr. S. Adil Husain and 3rd year integrated cardiac surgical resident Michal Schaffer of the University of Utah about these and other topics related to LV function following the Ross operation in children. ·         DOI: 10.1007/s00246-025-04124-9

BUFFALO, NY — December 30, 2025 — A new #research paper was #published in Volume 17, Issue 11 of Aging-US on November 26, 2025, titled “Epigenetic aging signatures and age prediction in human skeletal muscle.” In this study, first author Soo-Bin Yang and corresponding author Hwan Young Lee from Seoul National University College of Medicine investigated how DNA methylation patterns in skeletal muscle change with age. Their findings offer a new and highly accurate method for estimating a person's age, with potential applications in forensic science and aging research. Skeletal muscle is essential for movement, energy balance, and physical strength, functions that become more important to monitor as people age. This study improves our understanding of how muscle tissue changes over time at the molecular level. Unlike previous research, which mainly analyzed living individuals of European descent, this study used postmortem samples from an Asian population. “We analyzed DNA methylation profiles from 103 pectoralis major muscle samples from autopsies of South Korean individuals (18–85 years) using the Infinium EPIC array.” The researchers analyzed DNA from over 100 pectoralis major muscle samples taken from individuals aged 18 to 85. They identified 20 DNA methylation sites, called CpGs, that were strongly associated with age. These CpGs were found in genes involved in muscle function, stress response, metabolism, and age-related diseases. Using these markers, the team built two machine learning models to predict age: one using Next-Generation Sequencing (NGS) and another using Single Base Extension (SBE). Both models were highly accurate, with average prediction errors between 3.8 and 5.5 years. The new “epigenetic clocks” outperformed existing age-prediction models designed for other tissue types. However, when applied to cardiac and uterine muscle, these models showed much lower accuracy, reinforcing the need for tissue-specific approaches in molecular age estimation. Beyond predicting age, the study also provides insight into how DNA methylation may affect muscle aging. Several of the identified CpGs were located in regions that regulate gene expression, being associated with a reduction of it in older muscle samples. Some of the affected genes are associated with sarcopenia, an age-related loss of muscle mass and strength. Overall, this study introduces two reliable and cost-effective methods to estimate age from skeletal muscle, even when the DNA is partially degraded, making it especially useful in forensic settings. It also offers a path forward for developing future therapies that may slow age-related muscle decline and highlights how skeletal muscle aging can differ depending on population, tissue type, and anatomical location. DOI - https://doi.org/10.18632/aging.206341 Corresponding author - Hwan Young Lee - hylee192@snu.ac.kr Abstract video - https://www.youtube.com/watch?v=1i6Ua0cceMU Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206341 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, skeletal muscle, age, DNA methylation, next generation sequencing, single base extension To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

HIV Patients' Perceptions of a Potential Multi-Component Mindfulness-Based Smoking Cessation Smartphone Application InterventionIn this episode, Dr. Jud explores a pivotal study on adapting a mindfulness-based smoking cessation app for people living with HIV (PLWH). This research highlights how a multi-component intervention—combining mindfulness training, contingency management, and adherence tracking for antiretroviral therapy—addresses the unique challenges faced by PLWH smokers. Discover the app's potential to reduce smoking-related health disparities, its innovative features, and participant insights on feasibility, acceptability, and improvement opportunities.Reference: Asfar, T., Alcaide, M. L., Jones, D. L., McClure, L. A., Brewer, J., Lee, D. J., & Carrico, A. (2022). HIV patients' perceptions of a potential multi-component mindfulness-based smoking cessation smartphone application intervention. PLOS ONE, 17(8), e0271946. DOI: 10.1371/journal.pone.0271946.Let's connect on Instagram

Common knowledge suggests that albino animals are rare in the wild because they stick out like a sore thumb and get eaten by predators, but studies supporting this are relatively scarce. Now, researchers from Australia have discovered that the drawbacks of albinism are not limited to their obvious appearance. Even better, they used our old friends cane toads to prove it. Become a Patreon: https://www.patreon.com/herphighlights Merch: https://www.redbubble.com/people/herphighlights/shop Full reference list available here: http://www.herphighlights.podbean.com Main Paper References: Funk AT, Martin J, Clark M, Païta A, Jolly CJ, Shine R. 2025. Knocking out genes to reveal drivers of natural selection on phenotypic traits: a study of the fitness consequences of albinism. Proceedings of the Royal Society B: Biological Sciences 292:20251458. DOI: 10.1098/rspb.2025.1458. Other Mentioned Papers/Studies: Clark MB, Funk AT, Paporakis A, Brown GP, Beach SJ, Tay A, Deering S, Cooper C, Tizard M, Jolly CJ, Ward-Fear G, Waddle AW, Shine R, Maselko M. 2025. Efficient CRISPR-Cas9-Mediated Genome Editing of the Cane Toad ( Rhinella marina ). The CRISPR Journal 8:321–332. DOI: 10.1177/25731599251382427. Stephenson BP, Velani Z, Ihász N. 2022. The effect of albinism on avian predator attack rates in eastern garter snakes. Zoology 150:125987. DOI: 10.1016/j.zool.2021.125987. Other Links/Mentions: Motorbike frog call from: https://www.inaturalist.org/taxa/517096-Ranoidea-moorei  Editing and Music: Intro/outro – Treehouse by Ed Nelson Species Bi-week theme – Michael Timothy Other Music – The Passion HiFi, https://www.thepassionhifi.com

Deze week hoor je in NRC Vandaag onze serie Wilde eeuwen, het begin. Een van de verhalende series die we dit jaar maakten: perfect voor tijdens de dagen rond Kerst.Het is 40.000 jaar geleden. De jonge Doi staat oog in oog met zijn verre familie, een groep dansende neanderthalers. Zullen ze hem accepteren? Heeft u vragen, suggesties of ideeën over onze journalistiek? Mail dan naar onze redactie via podcast@nrc.nl.Voor deze aflevering is onder meer gebruikt gemaakt van deze literatuur: Francesca Romagnoli e.a. (eds) ‘Updating Neanderthals. Understanding Behavioural Complexity in the Late Middle Palaeolithic', Academic Press 2022 Mateja Hajdinjak e.a ‘Initial Upper Palaeolithic humans in Europe had recent Neanderthal ancestry' in Nature 8 april 2021. Rebecca Wragg Sykes. ‘Kindred. Neanderthal Life, Love, Death and Art', Bloomsbury 2021 Rudolf Botha. ‘Neanderthal Language. Demystifying the Linguistic Powers of our Extinct Cousins', Cambridge University Press 2020 Katerina Harvati. ‘Paleoanthropology of the Balkans and Anatolia. Human Evolution and its Context', Springer Press 2016 Qiaomei Fu e.a. ‘An early modern human from Romania with a recent Neanderthal ancestor' in Nature, 13 augustus 2015.Wil Roebroeks en Paola Villa ‘Neandertal Demise: An Archaeological Analysis of the Modern Human Superiority Complex' in PLOS One, 30 april 2014.João Zilhão e.a. ‘The Peştera cu Oase People. Europe's Earliest Modern Humans' in K. Boyle e.d. (eds) Rethinking the Human Revolution, McDonald Institute for Archaeological Research, 2007.Tekst en presentatie: Hendrik SpieringRedactie en regie: Mirjam van ZuidamMuziek, montage en mixage: Rufus van BaardwijkBeeld: Jeen BertingVormgeving: Yannick MortierZie het privacybeleid op https://art19.com/privacy en de privacyverklaring van Californië op https://art19.com/privacy#do-not-sell-my-info.

BUFFALO, NY — December 23, 2025 — A new #research paper was #published in Volume 17, Issue 11 of Aging-US on November 25, 2025, titled “A natural language processing–driven map of the aging research landscape.” In this study, Jose Perez-Maletzki from Universidad Europea de Valencia and Universitat de València, together with Jorge Sanz-Ros from Stanford University School of Medicine, used artificial intelligence (AI) to analyze a century of global aging research, revealing shifts in focus and highlighting underexplored areas. The team analyzed over 460,000 scientific abstracts published between 1925 and 2023 to identify key themes, trends, and research gaps in the study of aging. Their goal was to provide a comprehensive, unbiased view of how the field has evolved and where future research could have the greatest impact. The study found that aging research has moved from basic cellular studies and animal models to a growing focus on clinical topics, particularly age-related diseases such as Alzheimer's and dementia. Using natural language processing and machine learning, the researchers grouped publications into thematic clusters and tracked how interest in each topic changed over time. “By integrating Latent Dirichlet Allocation (LDA), term frequency-inverse document frequency (TF-IDF) analysis, dimensionality reduction and clustering, we delineate a comprehensive thematic landscape of aging research.” One key finding was the growing separation between basic biological studies and clinical research. While both areas have grown significantly, they often progress independently with limited overlap. Clinical studies tend to focus on geriatrics, healthcare, and neurodegenerative diseases, while basic science emphasizes cellular mechanisms such as oxidative stress, telomere shortening, mitochondrial dysfunction, and senescence. The authors note that this lack of integration limits the translation of laboratory discoveries into medical applications. The study also showed that some emerging topics, such as autophagy, RNA biology, and nutrient sensing, are expanding rapidly but remain separated from clinical applications. In contrast, long-established links, such as those between cancer and aging, remain strong. The analysis also highlighted that potentially important associations, such as those between mitochondrial dysfunction and senescence or epigenetics and autophagy, are rarely studied and may be new research opportunities. This AI-driven analysis offers a new way to guide future research by identifying how different areas of aging science are interconnected or isolated. It also highlights how research priorities may be shaped by policy or funding trends, as seen in the heavy focus on Alzheimer's disease. As the global population continues to age, understanding how biological processes relate to clinical outcomes is critical. This study not only offers a historical map of aging science but also serves as a tool to support more connected, interdisciplinary, and effective future research. DOI - https://doi.org/10.18632/aging.206340 Corresponding author - Jorge Sanz-Ros - jsanzros@stanford.edu Abstract video - https://www.youtube.com/watch?v=O4dJUGQ2ZcU Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Aproximativ 30.000 de susținători ai mișcării MAGA s-au adunat de joi până duminică la Phoenix, Arizona pentru AmericaFest. A fost prima mare conferință organizată de Turning Point, după uciderea fondatorului mișcării, Charlie Kirk. Însă această reuniune anuală a conservatorilor americani a scos la iveală certurile interne din cadrul mișcării pro-Trump, observă comentatorii. „Liderii conservatori au schimbat insulte, dezvăluind diviziuni profunde” pe teme variate precum „teoriile conspirației, antisemitismul și întrebarea cine aparține Americii”, observă The New York Times, citat de Courrier International. „Problemele care divizează mișcarea includ „renașterea antisemitismului, prevalența teoriilor conspirației și apariția conceptului de «nativi americani» și ceea ce înseamnă acest concept - considerat de unii conservatori non-albi un mesaj rasist abia disimulat”. Potrivit The Guardian, ”unitatea observată în anii precedenți a fost pusă sub semnul întrebării de nemulțumiri interpersonale și dezacorduri cu privire la cât de mare ar trebui să fie umbrela conservatorismului și ce tipuri de gândire conservatoare ar putea să cuprindă”. Ostilitățile au început încă de joi, odată cu intervenția influentului Ben Shapiro, cofondator al publicației media conservatoare The Daily Wire, care a susținut că mișcarea MAGA este în „pericol grav” din cauza „șarlatanilor”, „escrocilor” și „profitorilor”, relatează Axios. Shapiro a atacat mai multe figuri conservatoare de top, inclusiv prezentatorii de talk-show-uri Megyn Kelly și Tucker Carlson, influencer-ul Candace Owens și Steve Bannon, fostul strateg politic al lui Donald Trump. Potrivit Axios, mișcarea MAGA, „atât de unită în timpul campaniei electorale a președintelui Trump și în mare parte federată” în urma uciderii lui Charlie Kirk, este în mod clar „prinsă într-o luptă deschisă pentru putere” în perspectiva alegerilor prezidențiale din 2028. ”Febrilă și divizată, dreapta populistă americană se gândește deja la era post-Trump”, observă Le Monde. Aceasta ”nu are nicio legătură cu costul vieții, care este totuși principala preocupare a opiniei publice. În cadrul bulei MAGA se ridică două întrebări fundamentale. Prima privește Israelul, care ocupă un loc disproporționat în mintea publicului și a actorilor politici. A doua întrebare, conexă, privește însăși definiția mișcării populiste naționaliste americane, această coaliție eterogenă formată în urma lui Donald Trump. Pentru a dăinui, trebuie să fie incluzivă sau exclusivă? Doi termeni ireconciliabili”. Politico remarcă faptul că vicepreședintele JD Vance a încercat să treacă peste furtuna MAGA de la Turning Point. ”Discursul său de la Centrul de Convenții Phoenix a fost punctul culminant al unui festival de un weekend întreg pentru 30.000 dintre cei mai înfocați susținători ai președintelui Donald Trump. Dar până duminică, o mare parte a weekendului a fost umbrită de o schismă în interiorul partidului”. După cum transmite Fox News, Erika Kirk și-a declarat susținerea pentru JD Vance în rolul de „moștenitor aparent” al MAGA. ”Sprijinul acordat de către Turning Point, o organizație deosebit de influentă în rândul conservatorilor mai tineri, i-ar putea oferi lui Vance un impuls major în cazul în care acesta va decide să candideze la președinție în alegerile din 2028”.

On this, our 306th Evolutionary Lens livestream, we discuss men and women, relationships and strategies. What is actually true of young women right now? Is the manosphere onto some uncomfortable and deep truths, or do they suffer from sampling and confirmation bias? What role is porn playing? Social media? Is the nonsense that emerged from #MeToo, with regard to blaming all men, seeing an analog now in the blaming of women? However: men and women are different. Women are more likely to think they have a “right to be right,” to embrace ideologies that privilege victims and grievances, and to be neurotic. Just as encouraging men to embrace their emotional side can enhance many men's lives, encouraging women to embrace the physical world is likely to enhance their lives. Finally: a book recommendation (Playground).*****Our sponsors:Manukora: the most delicious and nutritious honey you'll ever have. Get up to 31% off + $25 of free gifts with the Starter Kit at www.Manukora.com/DarkHorsePrima: Ancestral high-protein bars, easy and delicious, now in four great flavors. 20% off at EatPrima.com/DarkHorse.CrowdHealth: Pay for health care with crowdfunding instead of insurance. It's way better. Use code DarkHorse at JoinCrowdHealth.com to get 1st 3 months for $99/month.*****Join us on Locals! Get access to our Discord server, exclusive live streams, live chats for all streams, and early access to many podcasts: https://darkhorse.locals.comHeather's newsletter, Natural Selections (subscribe to get free weekly essays in your inbox): https://naturalselections.substack.comOur book, A Hunter-Gatherer's Guide to the 21st Century, is available everywhere books are sold, including from Amazon: https://amzn.to/3AGANGg (commission earned)Check out our store! Epic tabby, digital book burning, saddle up the dire wolves, and more: https://darkhorsestore.org*****Mentioned in this episode:BSW on male-female dynamics, and response from @MichaelPThelen: https://x.com/thedarkhorsepod/status/2002077458758279397 Thelwall 2017 (1of2). Book genre and author gender in Goodreads: Romance>paranormal-romance to autobiography>memoir. Journal of the Association for Information Science and Technology 68(5):1212–1223. DOI:10.1002/asi.23768. Playground, by Richard Powers: https://www.powells.com/book/playground-9781324123736Support the show

In today's episode, we dig into one of the most powerful (and most misunderstood) features of the human brain: your built in negativity bias. You'll learn:why your brain holds onto negative experienceswhy “reality” is filtered, not objectivehow the Reticular Activating System (RAS) decides what you noticeand how mountain biking is a surprisingly effective tool for retraining your attentionIf you've ever wondered why one bad ride, one mistake, or one negative comment sticks in your mind far longer than all the good stuff combined, this episode will finally help you make sense of it and CHANGE it! You'll learn practical, science-backed tools to start training your attention today (on the trail and in daily life) so your brain becomes better at noticing possibilities, capabilities, and micro-wins instead of dangers and mistakes to build a more supportive inner environment.We explore:Baumeister et al., “Bad Is Stronger Than Good”the fast subcortical threat pathway that triggers your amygdala before you can thinkwhy positive moments fade unless you consciously reinforce themhow attention literally rewires your neural pathway Hebbian learningand why your RAS acts like a “bouncer,” filtering your world based on what you engage with✨ Patreon Bonus: Patrons get a free downloadable cheat sheet that summarizes all tools and concepts from today's episode.Join here to get it PLUS other exclusive perks: https://www.patreon.com/c/rideandinspire This episode is not sponsored. It's made possible by the lovely humans who support my work on Patreon. If you want to help me keep creating science-based, real-talk MTB content, JOIN my Patreon, thank you.

In our latest episode, Deputy Editor Dr. Zam Kassiri (University of Alberta) interviews authors Dr. German González (Pontificia Universidad Católica Argentina), Dr. Rebecca Ritchie (Monash University), Dr. Pooneh Bagher (University of Nebraska Medical Center), and Dr. Hiroe Toba (Kyoto Pharmaceutical University) about the latest Guidelines in Cardiovascular Research article by Sveeggen et al. that helps researchers tackle the sources of variability in experimental models of diet-induced cardiometabolic syndrome. This podcast is a must-listen for any researcher using a diet-induced food model of disease. The authors discuss different food composition with details about type and source of fat and macronutrients, as well as environmental factors that can influence metabolic outcomes. These guidelines serve as a framework for researchers to optimize dietary interventions in cardiometabolic syndrome models and improve the predictive value of preclinical findings for translational applications. Listen now to hear more, including bonus multi-language summaries in both Spanish and Japanese.   Timothy M. Sveeggen, Pooneh Bagher, Hiroe Toba, Merry L. Lindsey, Rebecca H. Ritchie, Verónica J. Miksztowicz, and Germán E. González Guidelines for diet-induced models of cardiometabolic syndrome Am J Physiol Heart Circ Physiol, published October 7, 2025. DOI: 10.1152/ajpheart.00359.2025

BUFFALO, NY — December 19, 2025 — A new #research paper was #published in Volume 17, Issue 11 of Aging-US on November 18, 2025, titled “Epigenetic age predicts depressive symptoms during the COVID-19 pandemic in the Canadian Longitudinal Study on Aging: importance of biological sex.” This study, led by Cindy K. Barha of the University of Calgary and the University of British Columbia, along with Teresa Liu-Ambrose of the University of British Columbia, found that older women with a younger biological age measured years before the COVID-19 pandemic experienced a greater increase in depressive symptoms during the early lockdown period. These findings could help shape future mental health strategies, particularly for women with high emotional or caregiving demands. Epigenetic age is a biological marker that reflects how the body is aging and may differ from a person's actual age. Using long-term data from the Canadian Longitudinal Study on Aging (CLSA), the researchers investigated whether epigenetic age could predict changes in mental health during a major public health crisis. The study included over 600 adults, with an average baseline age of 63, and used two widely accepted epigenetic clocks, the DNAmAge and the Hannum Age, to estimate biological age. Depressive symptoms were tracked at four time points between 2012 and 2020, including during the height of the pandemic. “The mean participant chronological age at study entry was 63±10 years (46% female).” The analysis showed that in women, a younger biological age predicted a greater rise in depression during the early phase of the COVID-19 pandemic. This was not observed in men or in individuals with older biological ages. The study challenges the common belief that a younger biological age always signals better mental or physical resilience. The researchers suggest that women with younger biological profiles may have been more socially or professionally active before the pandemic. When lockdowns disrupted daily routines and social connections, these individuals may have experienced more emotional distress. Additional factors, such as reduced physical activity, loss of routine, and decreased social interaction, known to affect both mental health and biological aging, may have had a stronger emotional effect on this group. The findings highlight the importance of considering biological sex when studying how aging affects mental well-being during stressful events. Although the study has some limitations, including the time gap between biological age measurement and the pandemic, it gives valuable insights into how biological and social factors interact during periods of crisis. Future research could use epigenetic clocks to better identify individuals at greater risk of mental health challenges during large-scale public health emergencies. Overall, this study adds to the growing field of social epigenetics and suggests that biological age may support more targeted public health planning, especially for older adults. DOI - https://doi.org/10.18632/aging.206337 Corresponding author - Teresa Liu-Ambrose - teresa.ambrose@ubc.ca Abstract video - https://www.youtube.com/watch?v=DVm78jKsdkY Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

In this special edition on Adherence to Medications our host, Dr. Neil Skolnik will discuss medication adherence and the role of clinicians, pharmacies and pharmacists in helping with medication adherence. This special episode is supported by an independent educational grant from Amazon. Presented by: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health Susan Kuchera, M.D. - Clinical Assistant Professor of Family and Community Medicine at the Sidney Kimmel Medical College of Thomas Jefferson University and Program Director of the Family Medicine Residency at Jefferson Health Abington. Tess Carey, PharmD, Clinical Advisor for Amazon Pharmacy  Selected references: Better Medications Adherence Lowers Cardiovascular Events, Stroke, and All-Cause Mortality Risk: A Dose-Response Meta-Analysis. Journal of Cardiovascular Development and Disease. 2021, 8, 146. Adherence to antihypertensive medications for secondary prevention of cardiovascular disease events: a dose-response meta-analysis. Public Health 196 (2021) 179e185 Medication nonadherence - definition, measurement, prevalence, and causes: reflecting on the past 20 years and looking forwards. Frontiers in Pharmacology, March 2025. DOI 10.3389/fphar.2025.1465059  

To end this season's HOTLINE, we had our callers cum back : shout out to Mads, Anne ... and ARIELLE! Guess the Guest na naka-stay on hanggang ending, at sino ang mga nalaglag! In on this HOT fun are our favorite co-hosts : Ueda-san, Giwan and Doi. Surprise, kasali si Dusco! Hahaha, yes ... host pa rin sya! Hosted on Acast. See acast.com/privacy for more information.

New methods in antivenom technology may yield a treatment that works on most of the cobras in Africa, thanks to the blood of alpacas and some very clever scientists. Then we follow up with two new species of sleepyhead snake from Venezuala. Become a Patreon: https://www.patreon.com/herphighlights Merch: https://www.redbubble.com/people/herphighlights/shop Full reference list available here: http://www.herphighlights.podbean.com Main Paper References: Ahmadi S, Burlet NJ, Benard-Valle M, Guadarrama-Martínez A, Kerwin S, Cardoso IA, Marriott AE, Edge RJ, Crittenden E, Neri-Castro E, Fernandez-Quintero ML, Nguyen GTT, O'Brien C, Wouters Y, Kalogeropoulos K, Thumtecho S, Ebersole TW, Dahl CH, Glegg-Sørensen EU, Jansen T, Boddum K, Manousaki E, Rivera-de-Torre E, Ward AB, Morth JP, Alagón A, Mackessy SP, Ainsworth S, Menzies SK, Casewell NR, Jenkins TP, Ljungars A, Laustsen AH. 2025. Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites. Nature. DOI: 10.1038/s41586-025-09661-0. Species of the Bi-Week: Esqueda LF, Rojas-Runjaic FJM, Prudente A, Bazó S, Navarrete LF, Carmargo-Sillet E, Ortiz JC, Correa C, Guerrero P, Urra F. 2025. A first phylogenetic and taxonomic approach to sleepyhead snakes from Venezuela (Dipsadidae: Atractus), with the description of two new Andean species. Organisms Diversity & Evolution. DOI: 10.1007/s13127-025-00682-1. Other Links/Mentions: https://www.redbubble.com/people/herphighlights/shop  Editing and Music: Intro/outro – Treehouse by Ed Nelson Species Bi-week theme – Michael Timothy Other Music – The Passion HiFi, https://www.thepassionhifi.com

BUFFALO, NY - December 17, 2025 – A new #research paper was #published in Oncotarget (Volume 16) on December 15, 2025, titled “Machine learning-based survival prediction in colorectal cancer combining clinical and biological features.” In this study, led by Lucas M. Vieira from the University of Brasília and the University of California San Diego, researchers used machine learning to predict survival in patients with colorectal cancer. They built a model by combining biological markers with clinical data. This approach could help improve prognosis and guide treatment strategies for one of the world's most common and deadly cancers. The team analyzed data from over 500 patients, using clinical details such as age, chemotherapy status, and cancer stage, along with molecular features like gene expression and microRNAs. Their goal was to improve how clinicians identify high-risk patients and make outcome predictions more precise. Researchers evaluated three different patient data scenarios using different machine learning techniques. The best-performing was an adaptive boosting model, which achieved 89.58% accuracy. This approach showed that integrating clinical and biological data led to significantly better predictions than using either data type alone. Among the biological markers, the gene E2F8 was consistently influential in all patient groups and is known to play a role in tumor growth. Other important markers included WDR77 and hsa-miR-495-3p, which are also associated with cancer development. Key clinical predictors included cancer stage, patient age, lymph node involvement, and whether chemotherapy was administered. “The proposed method combines biological and clinical features to predict patient survival, using as input data from patients from the United States, available in the TCGA database.” Unlike earlier models that relied on either clinical or molecular data alone, this study demonstrates the added value of combining both. Ensemble methods, which merge multiple learning algorithms, provided more stable and consistent results across all patient groups tested. These research findings could lead to new tools that help clinicians better predict how a patient's disease might progress or respond to treatment. The study also highlights the importance of collecting complete clinical information, such as lifestyle factors, which were missing from the dataset but could enhance future predictions. Overall, the study demonstrated how machine learning can support more accurate and personalized survival predictions in colorectal cancer. It also points to potential future research on markers like E2F8, which may be useful for monitoring or targeted therapy. DOI - https://doi.org/10.18632/oncotarget.28783 Correspondence to - Lucas M. Vieira - lvieira@health.ucsd.edu Abstract video - https://www.youtube.com/watch?v=cy7UL5ZUKuI Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28783 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, colorectal cancer, machine learning, feature selection, non-coding RNAs, genes To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us on social media: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

Chegou o episódio escolhido por vocês! Marcela Belleza e Joanne Alves convidam Carol Millon para conversar sobe 6 clinicagens de inibidores de SGLT2, as gliflozinas:Indicações além do DMRisco de CAD euglicêmicaQuando não usar?⁠Cuidados com doença aguda (sick day) e hipovolemia⁠Cuidados pré-operatórioRisco de fratura e amputaçãoReferências:1. Bailey CJ, et al. Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled 102-week trial. BMC Med. 2013;11:43. Published 2013 Feb 20. doi:10.1186/1741-7015-11-432. Bersoff-Matcha SJ, et al. Fournier Gangrene Associated With Sodium-Glucose Cotransporter-2 Inhibitors: A Review of Spontaneous Postmarketing Cases. Ann Intern Med. 2019;170(11):764-769. doi:10.7326/M19-00853. Chang HY, et al. Association Between Sodium-Glucose Cotransporter 2 Inhibitors and Lower Extremity Amputation Among Patients With Type 2 Diabetes. JAMA Intern Med. 2018;178(9):1190-1198. doi:10.1001/jamainternmed.2018.3034 4. Clar C, et al. Systematic review of SGLT2 receptor inhibitors in dual or triple therapy in type 2 diabetes. BMJ Open. 2012 Oct 18;2(5):e001007. doi: 10.1136/bmjopen-2012-001007. PMID: 23087012; PMCID: PMC3488745.5. Das SR, et al. 2020 Expert Consensus Decision Pathway on Novel Therapies for Cardiovascular Risk Reduction in Patients With Type 2 Diabetes: A Report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol. 2020 Sep 1;76(9):1117-1145. doi: 10.1016/j.jacc.2020.05.037. Epub 2020 Aug 5. PMID: 32771263; PMCID: PMC7545583. 6. Fralick M, et al. Risk of amputation with canagliflozin across categories of age and cardiovascular risk in three US nationwide databases: cohort study. BMJ. 2020;370:m2812. Published 2020 Aug 25. doi:10.1136/bmj.m28127. Li D, et al. Urinary tract and genital infections in patients with type 2 diabetes treated with sodium-glucose co-transporter 2 inhibitors: A meta-analysis of randomized controlled trials. Diabetes Obes Metab. 2017;19(3):348-355. doi:10.1111/dom.128258. Neal B, et al. Rationale, design, and baseline characteristics of the Canagliflozin Cardiovascular Assessment Study (CANVAS)--a randomized placebo-controlled trial. Am Heart J. 2013;166(2):217-223.e11. doi:10.1016/j.ahj.2013.05.0079. Nyirjesy P, et al. Evaluation of vulvovaginal symptoms and Candida colonization in women with type 2 diabetes mellitus treated with canagliflozin, a sodium glucose co-transporter 2 inhibitor. Curr Med Res Opin. 2012;28(7):1173-1178. doi:10.1185/03007995.2012.69705310. Perkovic V, et al. Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy. N Engl J Med. 2019;380(24):2295-2306. doi:10.1056/NEJMoa181174411. Rosenwasser RF, et al. SGLT-2 inhibitors and their potential in the treatment of diabetes. Diabetes Metab Syndr Obes. 2013 Nov 27;6:453-67. doi: 10.2147/DMSO.S34416. PMID: 24348059; PMCID: PMC3848644.12. Sridharan K, Sivaramakrishnan G. Risk of limb amputation and bone fractures with sodium glucose cotransporter-2 inhibitors: a network meta-analysis and meta-regression. Expert Opin Drug Saf. 2025;24(7):797-804. doi:10.1080/14740338.2024.237775513. Ueda P,  et al. Sodium glucose cotransporter 2 inhibitors and risk of serious adverse events: nationwide register based cohort study. BMJ. 2018;363:k4365. Published 2018 Nov 14. doi:10.1136/bmj.k436514. Watts NB, et al. Effects of Canagliflozin on Fracture Risk in Patients With Type 2 Diabetes Mellitus. J Clin Endocrinol Metab. 2016 Jan;101(1):157-66. doi: 10.1210/jc.2015-3167. Epub 2015 Nov 18. PMID: 26580237; PMCID: PMC4701850.15. Zhuo M, et al. Association of Sodium-Glucose Cotransporter-2 Inhibitors With Fracture Risk in Older Adults With Type 2 Diabetes. JAMA Netw Open. 2021;4(10):e2130762. Published 2021 Oct 1. doi:10.1001/jamanetworkopen.2021.3076216. Emerson Cestari Marino, Leandra Anália Freitas Negretto, Rogério Silicani Ribeiro, Denise Momesso, Alina Coutinho Rodrigues Feitosa, Marcos Tadashi Kakitani Toyoshima, Joaquim Custódio da Silva Junior, Sérgio Vencio, Marcio Weissheimer Lauria, João Roberto de Sá, Domingos A. Malerbi, Fernando Valente, Silmara A. O. Leite, Danillo Ewerton Oliveira Amaral, Gabriel Magalhães Nunes Guimarães, Plínio da Cunha Leal, Maristela Bueno Lopes, Luiz Carlos Bastos Salles, Liana Maria Torres de Araújo Azi, Amanda Gomes Fonseca, Lorena Ibiapina M. Carvalho, Francília Faloni Coelho, Bruno Halpern, Cynthia M. Valerio, Fabio R. Trujilho,  Antonio Carlos Aguiar Brandão, Ruy Lyra e Marcello Bertoluci. Rastreamento e Controle da Hiperglicemia no Perioperatório – Posicionamento Conjunto da Sociedade Brasileira de Diabetes (SBD), Sociedade Brasileira de Anestesiologia (SBA) e Associação Brasileira para o Estudo da Obesidade e Síndrome Metabólica (ABESO). Diretriz Oficial da Sociedade Brasileira de Diabetes (2025). DOI: 10.29327/5660187.2025-10 , ISBN: 978-65-5941-367-6.17. Singh LG, Ntelis S, Siddiqui T, Seliger SL, Sorkin JD, Spanakis EK. Association of Continued Use of SGLT2 Inhibitors From the Ambulatory to Inpatient Setting With Hospital Outcomes in Patients With Diabetes: A Nationwide Cohort Study. Diabetes Care. 2024;47(6):933-940. doi:10.2337/dc23-112918. Mehta PB, Robinson A, Burkhardt D, Rushakoff RJ. Inpatient Perioperative Euglycemic Diabetic Ketoacidosis Due to Sodium-Glucose Cotransporter-2 Inhibitors - Lessons From a Case Series and Strategies to Decrease Incidence. Endocr Pract. 2022;28(9):884-888. doi:10.1016/j.eprac.2022.06.00619. Umapathysivam MM, Morgan B, Inglis JM, et al. SGLT2 Inhibitor-Associated Ketoacidosis vs Type 1 Diabetes-Associated Ketoacidosis. JAMA Netw Open. 2024;7(3):e242744. Published 2024 Mar 4. doi:10.1001/jamanetworkopen.2024.274420. Fleming N, Hamblin PS, Story D, Ekinci EI. Evolving Evidence of Diabetic Ketoacidosis in Patients Taking Sodium-Glucose Cotransporter 2 Inhibitors. J Clin Endocrinol Metab. 2020;105(8):dgaa200. doi:10.1210/clinem/dgaa20021. Neuen BL, Young T, Heerspink HJL, et al. SGLT2 inhibitors for the prevention of kidney failure in patients with type 2 diabetes: a systematic review and meta-analysis. Lancet Diabetes Endocrinol. 2019;7(11):845-854. doi:10.1016/S2213-8587(19)30256-622. Braunwald E. Gliflozins in the Management of Cardiovascular Disease. N Engl J Med. 2022;386(21):2024-2034. doi:10.1056/NEJMra211501123. Zinman B, Wanner C, Lachin JM, et al. Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes. N Engl J Med. 2015;373(22):2117-2128. doi:10.1056/NEJMoa150472024. Neal B, Perkovic V, Mahaffey KW, et al. Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes. N Engl J Med. 2017;377(7):644-657. doi:10.1056/NEJMoa161192525. Wiviott SD, Raz I, Bonaca MP, et al. Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med. 2019;380(4):347-357. doi:10.1056/NEJMoa181238926. McMurray JJV, Solomon SD, Inzucchi SE, et al. Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction. N Engl J Med. 2019;381(21):1995-2008. doi:10.1056/NEJMoa191130327. Packer M, Anker SD, Butler J, et al. Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure. N Engl J Med. 2020;383(15):1413-1424. doi:10.1056/NEJMoa202219028. Anker SD, Butler J, Filippatos G, et al. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. N Engl J Med. 2021;385(16):1451-1461. doi:10.1056/NEJMoa210703829. Heerspink HJL, Stefánsson BV, Correa-Rotter R, et al. Dapagliflozin in Patients with Chronic Kidney Disease. N Engl J Med. 2020;383(15):1436-1446. doi:10.1056/NEJMoa202481630. The EMPA-KIDNEY Collaborative Group, Herrington WG, Staplin N, et al. Empagliflozin in...

Summary: Where do tuatara live? Can I see one in MY backyard? Join Kiersten to find out if you can see a tuatara in your own backyard.   For my hearing impaired followers, a complete transcript of this podcast follows the show notes on Podbean   Show Notes: “Distribution of tuatara”, Te Ara: https://teara.govt.nz/en/map “Tuatara” by Marc E. H. Jones and Allison Cree. Current Biology, Vol 22, Issue 23, PR986-R987, Dec 4, 2012. DOI: 10.1016/j.cub.2012.10.049, https://www.cell.com/current-biology “Sphenodon punctatus (Tuatara)” Animal Diversity Web: https://www.animaldiversity.org Music written and performed by Katherine Camp   Transcript (Piano music plays) Kiersten - This is Ten Things I Like About…a ten minute, ten episode podcast about unknown or misunderstood wildlife. (Piano music stops)   Kiersten - Welcome to Ten Things I Like About… I'm Kiersten, your host, and this is a podcast about misunderstood or unknown creatures in nature. Some we'll find right out side our doors and some are continents away but all are fascinating.  This podcast will focus ten, ten minute episodes on different animals and their amazing characteristics. Please join me on this extraordinary journey, you won't regret it. Last week's overview of the tuatara probably made you want them in YOUR backyard, but they are only found in a small section of the world. This week we are going to find out where the tuatara live. The second thing I like about the tuatara is where they are found.  To see a tuatara in the wild you will have to visit New Zealand. They are found on different islands surrounding the main island of New Zealand as well as on the mainland. Those found on the mainland are there due to a reintroduction program begun in 2005.  The islands where you can find tuatara are fairly inaccessible which probably helped save them from extinction. The ones on the mainland were extinct before Europeans ever came to the island.  There are about thirty islands surrounding New Zealand where you can find tuatara today. Those island include Poor Knights Island, Hen and Chickens Island, Little Barrier Island, Cuveir Island, Mercury Island, The Alderman Island, Karewa Island, Plate Island, Moutoki Island, Moutohora Island, and Tiritiri Matangi Island. These are all off the northern coast. Sphenodon punctatus occurs naturally on all of these islands except Moutohora and Tiritiri Matangi Islands where the Northern Tuatara were introduced to help increase their population. Tuatara can also be found on Stephens or Takapourewa Island, Trio Island, Titi Island, The Brothers Island, and Matiu or Somes Island. Sphenodon guntheri occurs naturally on The Brothers Island and was introduced to Titi and Matiu Islands to boost their population. Please excuse any mispronunciations.  A scientific paper published in December of 2012 states that “there are about 32 natural populations of tuatara living on small offshore islands, a few island reintroductions, and at least one reintroduced mainland colony on the North Island [of New Zealand]. Most of the populations include just tens or hundreds of animals, but there are estimated to be at least 30,000 on Takapourewa Island.” End quote. The habitat that tuatara live in is an odd choice for a reptile as the islands are riddled with cliffs and exposed to strong winds. The vegetation is salt and wind tolerant; therefore, are pretty tough plants. The average temperature is below what the typical reptile can tolerate but tuatara are adapted to survive temperatures as low as 45 degrees Fahrenheit.  They spend their days in burrows that are dug by seabirds such as petrels, prions, and shearwaters when they are available or they will dig their own burrows. They also spend time soaking up the sun on the cliffs. Tuatara are more active at night leaving their burrows or basking spots to hunt for food. This episode is a bit shorter than my usual episodes and I do apologize. I will make it up to you in future episodes of the tuatara. Thank you for visiting with me to find out where the tuatara lives. It is my second favorite about this seriously cool animal. As the holiday season is upon us, I will be taking a break until the new year. We will pick up where we left off with the tuatara in January 2026. If you're enjoying this podcast please recommend me to friends and family and take a moment to give me a rating on whatever platform your listening. It will help me reach more listeners and give the animals I talk about an even better chance at change.  Join me in January 2026 for another exciting episode about the tuatara.        (Piano Music plays)  This has been an episode of Ten Things I like About with Kiersten and Company. Original music written and performed by Katherine Camp, my very own piano playing hero.

BUFFALO, NY — December 16, 2025 — A new #research paper was #published in Aging-US on December 10, 2025, titled “Theobromine is associated with slower epigenetic ageing.” In this study, led by Ramy Saad from King's College London and Great Ormond Street Hospital for Children NHS Foundation Trust, alongside Jordana T. Bell from King's College London, researchers found that higher levels of theobromine, a natural compound found in cocoa, are associated with slower biological aging in humans. The findings suggest that theobromine may support healthy aging. Epigenetic aging refers to biological changes that affect how genes function over time. It is measured using blood-based markers such as DNA methylation and telomere length, which together provide a more accurate picture of aging than chronological age. In this work, researchers analyzed data from two large European studies. In 509 women from the TwinsUK cohort, they found that higher blood levels of theobromine were associated with slower aging, especially based on GrimAge, an epigenetic clock that predicts the risk of age-related disease and early death. The results were confirmed in 1,160 men and women from the German KORA study. “We initially tested for the association between six metabolites found in coffee and cocoa, and epigenetic measures of ageing in blood samples from 509 healthy females from the TwinsUK cohort (median age = 59.8, IQR = 12.81, BMI = 25.35).“ Importantly, theobromine's effects were independent of related compounds such as caffeine. Even after adjusting for these other substances and different lifestyle factors, the association with slower aging remained strong. The study also associated higher theobromine levels with longer telomeres, another marker of healthy aging. While theobromine is commonly found in cocoa and chocolate, the study does not suggest increasing chocolate intake. However, it highlights the potential of everyday dietary components such as theobromine to influence aging. These findings support growing evidence that certain plant-based compounds may play a role in promoting long-term health. By identifying a connection between theobromine and slower biological aging, the study opens new directions for research into nutritional strategies for healthy aging. DOI - https://doi.org/10.18632/aging.206344 Corresponding authors - Ramy Saad - ramy.saad@kcl.ac.uk, and Jordana T. Bell - jordana.bell@kcl.ac.uk Abstract video - https://www.youtube.com/watch?v=S0P1USM8L6E Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206344 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, theobromine, epigenetic aging, DNA methylation, metabolomics, nutrition To learn more about the journal, visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Lucy may be the most famous Australopithecus fossil, but Selam is much better preserved. Researchers discovered this fossil in 2000 just across the river from where Lucy was found, and the recent exhibit at the Czech National Museum in Prague included this fossil as well as Lucy. In this episode, Paul and Todd review all the details from this skeleton, including a part that is completely unique in Australopithecus discoveries. What's the creationist angle on all this? You'll have to tune in to find out!Materials for this EpisodeWood, Todd Charles and Brummel, P. S. (2023) "Hominin Baraminology Reconsidered with Postcranial Characters," Proceedings of the International Conference on Creationism: Vol. 9, Article 28.DOI: 10.15385/jpicc.2023.9.1.15Available at: https://digitalcommons.cedarville.edu/icc_proceedings/vol9/iss1/28Does Lucy Prove Evolution? (Todd's Blog)https://toddcwood.blogspot.com/2025/01/does-lucy-prove-evolution.htmlPaul and Todd's Czech Anthropology Adventurehttps://toddcwood.blogspot.com/2025/10/paul-and-todds-czech-anthropology.htmleLucy - an evolutionary resource with scans of some of her boneshttps://elucy.org/National Museum of the Czech Republichttps://www.nm.cz/Episodes mentioned in this episodePlaylist of Paleoanthropology Episodeshttps://www.youtube.com/playlist?list=PLOzn-NecEi8EQEPL-CsmVZRo--osOXXFf

In this episode, Dr. Macy Bolt unpacks a recent study that utilizes a fan-favorite balance measure to better identify our patients who may have impaired cognitive function! DOI: 10.1519/JPT.0000000000000463 Want to make sure you stay up to date in all things Geriatrics in less than 3 minutes every other week? Join thousands of others in our free MMOA Digest Email list - https://institute-of-clinical-excellence.kit.com/a3837f54b7   

During the COVID-19 pandemic with lockdown mandates and social distancing, doctors, researchers, and the public were able to find refuge and community online; for the infectious disease community, it was on the social media platform Twitter, and more specifically under the widely used hashtag, #IDTwitter. Under new ownership from 2022, however, Twitter's name and brand changed to what we now know as X, and “the heyday of #IDTwitter is long since gone”. In this special episode of Communicable, Angela Huttner and Marc Bonten invite doctors and science communicators, Neil Stone (London, UK), Ilan Schwartz (Durham, USA), and Tara Smith (Kent, USA) to debate whether we should stay on X or leave it for alternatives.This episode is a follow-up from Stone and Schwartz's commentary [1] and Smith's response letter [2] addressing the same topic published in CMI Communications. The views expressed by the panelists are their own and do not represent the positions of their affiliated institutions or ESCMID. This episode was not peer reviewed.ResourcesYou can follow all participants of this episode on Bluesky: @drneilstone.bsky.social, @germhuntermd.bsky.social, @aetiology.bsky.social, @marcbonten.bsky.social, @angelahuttner.bsky.social, and Stone on X: @DrNeilStone.ReferencesStone NRH and Schwartz IS. Joining the X-odus: Contrasting perspectives on whether infection specialists should leave X (formerly Twitter). CMI Comms 2025. DOI: 10.1016/j.cmicom.2025.105140Smith TC. Twitter remains a haven of harassment. CMI Comms 2025. DOI: 10.1016/j.cmicom.2025.105144Further readingBiever, C. Bluesky's science takeover: 70% of Nature poll respondents use platform. Nature News 2025. PEW Research Center. How Do Americans View Childhood Vaccines, Vaccine Research and Policy? https://www.pewresearch.org/science/2025/11/18/how-do-americans-view-childhood-vaccines-vaccine-research-and-policy/   NBC News. X's new location labels unmask users. Insiders say the idea was rejected for years. https://www.nbcnews.com/tech/elon-musk/x-user-location-feature-country-elon-musk-new-rcna245620

In dieser Vorlesung behandle ich das Spannungsfeld Grammatik und Grammatikographie im Kontext der Konstruktionsgrammatik. Im Mittelpunkt stehen zwei Fragen: Wie bringen wir den holistischen Anspruch der Konstruktionsgrammatik, das gesamte Sprachwissen zu erfassen, mit der Dynamik des Sprachwandels in Einklang? Und in welcher Art und Weise sind das mentale Konstruktikon und ein (Referenz-)Konstruktikon zu berücksichtigen? Ich diskutiere entlang dieser Fragen das Lexikon-Grammatik-Kontinuum. Abschließend erörtere ich kurz vor dem Hintergrund der praktischen Tests im #MKNetwork, inwiefern generative KI die Arbeit der Konstruktographie in Zukunft unterstützen kann.Präsentation (*.pdf): Alexander Lasch. 2025. Konstruktionsgrammatik. Zenodo. DOI: ⁠https://doi.org/10.5281/zenodo.17370032⁠. Videoaufzeichnungen: ⁠⁠⁠⁠⁠⁠⁠⁠https://youtube.com/@AlexanderLasch⁠⁠⁠⁠⁠⁠⁠⁠. Informationen & Material zu allen Vorlesungen: ⁠⁠⁠⁠⁠⁠⁠⁠https://kurzelinks.de/fl7f⁠⁠⁠⁠⁠⁠⁠⁠. Worksheet zu den Vorlesungen: ⁠⁠https://kurzlinks.de/WorksheetVorlesungen⁠⁠. Intro: "Reflections" von Scott Holmes (CC BY via ⁠⁠⁠⁠⁠⁠FMA⁠⁠⁠⁠⁠⁠).#Linguistik #OER #Sprache #Sprachwissenschaft #Grammatik #Konstruktionsgrammatik

This week we speak with noted congenital cardiologist Professor Krishna Kumar of the Amrita Institute in Cochin, India and discuss his recent work on inequities in congenital heart care in the world. Over 90% of patients with CHD do not have access to care in the globe today. What is the path forward to improve this sobering statistic? How can a World Health Assembly resolution practically help improve care in LMIC countries worldwide? Dr. Kumar shares his deep insights.This week we also briefly note the passing of the wonderful and caring pediatric cardiologist Dr. Sangeetha Viswanathan of Chennai, India who tragically died suddenly this week while attending the World Congress events in Hong Kong. Dr. Kumar's words regarding his friend, former fellow and colleague are read in remembrance of this wonderful and giving cardiologist whose loss will be deeply felt by her patients, family and friends. DOI: 10.1016/j.jacc.2025.07.070

BUFFALO, NY — December 12, 2025 — A new #research paper was #published in Volume 17, Issue 11 of Aging-US on November 14, 2025, titled “Methylglyoxal-induced glycation stress promotes aortic stiffening: putative mechanistic roles of oxidative stress and cellular senescence.” The study was led by first authors Parminder Singh of the Buck Institute for Research on Aging and Ravinandan Venkatasubramanian of the University of Colorado Boulder, with senior contributions from corresponding authors Pankaj Kapahi (Buck Institute for Research on Aging) and Zachary S. Clayton (University of Colorado Boulder and University of Colorado Anschutz Medical Campus). The researchers investigated how methylglyoxal (MGO), a toxic byproduct that builds up in blood vessels with age or metabolic dysfunction like diabetes, contributes to artery stiffening. Their findings are especially important to aging and diabetes-related cardiovascular risk. Aortic stiffening, which reduces the flexibility of the body's largest artery, is a key predictor of cardiovascular disease in older adults. The research team used young and aged mice to study how MGO affects vascular health. In young mice, chronic exposure to MGO increased aortic stiffness by 21%. However, when treated with Gly-Low, a supplement containing natural compounds such as nicotinamide and alpha-lipoic acid, this stiffening was completely prevented. Gly-Low also reduced the buildup of MGO and its harmful byproducts, particularly MGH-1, in both blood and tissue. “Aortic stiffness was assessed in vivo via pulse wave velocity (PWV) and ex vivo through elastic modulus.” The research showed that MGO's damage goes beyond structural changes. It also caused the endothelial cells that line blood vessels to enter senescence, a state in which cells stop dividing and begin releasing inflammatory signals. This led to lower levels of nitric oxide, a molecule essential for blood vessel relaxation. In human vascular cells in lab culture, Gly-Low reversed these aging-like changes and restored nitric oxide production. In older mice, which naturally develop stiffer arteries, Gly-Low treatment during four months significantly reduced stiffness and lowered MGO and MGH-1 levels. This suggests that Gly-Low may help slow or even reverse vascular aging by reducing glycation stress. The study also identified the glyoxalase-1 pathway as a critical mechanism. This is a natural detox system that helps clear harmful molecules like MGO. Gly-Low appeared to boost this pathway. When the pathway was chemically blocked, Gly-Low's protective effects disappeared, confirming its role in the process. Overall, the findings highlight glycation stress as a modifiable contributor to vascular aging. The results suggest that natural compound-based therapies, like Gly-Low, may offer a potential strategy to protect arteries from age- and diabetes-related damage. DOI - https://doi.org/10.18632/aging.206335 Corresponding authors: Pankaj Kapahi - pkapahi@buckinstitute.org; Zachary S. Clayton - Zachary.Clayton@cuanschutz.edu Abstract video: https://www.youtube.com/watch?v=i_rtq8eIb8c Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Send us a textRewiring Dry Eyes: Nasal Spray Boosts Tears in Sjögren's In this episode, we unpack a 2025 pilot study from the University of Pennsylvania that tested varenicline nasal spray for dry eye disease in Sjögren's patients. Learn how neural stimulation through the nose improved tear production, reduced inflammation, and offered new hope for one of ophthalmology's most challenging autoimmune conditions.Source: Gupta AS et al., Clinical Ophthalmology. 2025;19:1073–1084. DOI: 10.2147/OPTH.S512364.LINK: Varenicline solution nasal spray for the treatment of dry eye disease | OPTH

Send us a textEric Vona describes how project-based learning can guide students from broad worries to focused, researchable questions that lead to local solutions. He talks about place-based writing born during remote learning, then shows how journalism practices—finding experts, crafting professional emails, conducting interviews—help students produce credible, public-facing work. Literature becomes a springboard for ethics and action. Pairing Ursula K. Le Guin's The Ones Who Walk Away from Omelas with contemporary responses opens honest talk about comfort, cost, and justice—conversations that translate directly to climate realities. Eric also spotlights The Echo, a teen literary magazine turned nonprofit, where students serve as real editors, publish global youth voices, and record audio for accessibility. It's a model of authentic learning that lasts beyond a grading period and builds the very capacities communities need now: curiosity, collaboration, and clear communication.John Eric Vona is a writer and educator living in Tampa, FL. Passionate about conservation and sustainability, he joined the Stories-To-Live-By project so that he could find ways to bring place-centered writing into his work as a high school AP Capstone Seminar and Creative Writing instructor. He is proud to be the advisor to The Echo: Teen Art & Lit Mag, which publishes the work of artists and writers from around the world aged 13-19. You can find The Echo at echolitmag.com/. Other resources mentioned in this episode:University of Oregon's Journalistic Learning Initiative can be found at https://journalisticlearning.org/.To cite this episode:Persohn, L. (Host). (2025,Nov 11). Stories-To-Live-By with John Eric Vona. (Season 6, No. 5) [Audio podcast episode]. In Classroom Caffeine Podcast series. https://www.classroomcaffeine.com/guests. DOI: 10.5240/6C5D-9DA8-6973-6DE9-90CA-1Connect with Classroom Caffeine at www.classroomcaffeine.com or on Instagram, Facebook, Twitter, and LinkedIn.

The paper featured on the cover of this issue of Aging-US, published on October 30, 2025, entitled “SAMP-Score: a morphology-based machine learning classification method for screening pro-senescence compounds in p16-positive cancer cells,” represents an important methodological and conceptual advance at the interface of senescence biology, imaging and drug discovery. In this study, led by first author Ryan Wallis and corresponding author Cleo L. Bishop (Queen Mary University of London), the authors introduce SAMP-Score, a machine-learning–based framework designed to identify bona fide senescence induction in cancer cells where canonical markers fail. This is a timely and much-needed contribution to the field. Therapy-induced senescence has emerged as a powerful strategy to restrain tumor growth, yet its reliable detection in cancer cells remains a major bottleneckIn these contexts, cells often already display features associated with cellular aging, rendering conventional senescence markers ambiguous or misleading. Distinguishing true senescence from toxicity, stress responses or baseline “aged” phenotypes is therefore a critical unmet need. Rather than relying on predefined molecular readouts, the authors take a different approach and train a machine-learning model to recognize senescence-associated morphological profiles (SAMPs) which are subtle but reproducible changes in cellular architecture captured through high-content microscopy. By learning directly from image-based phenotypes, SAMP-Score is able to identify senescence with a level of precision that is difficult to achieve using marker-based strategies alone. The strength of the platform demonstrated through a large-scale screen of over 10,000 novel chemical entities in p16-positive basal-like breast cancer cells. From this screen, the compound QM5928 emerged as a robust inducer of senescence across multiple cancer models, notably without inducing cytotoxicity. Importantly, QM5928 retains activity in cellular contexts that are resistant to CDK4/6 inhibition, including palbociclib-refractory, p16-high tumors. Mechanistically, the authors show that QM5928 promotes nuclear relocalization of p16, consistent with a functional engagement of cell-cycle arrest pathways. These nuanced phenotypic changes would likely have gone undetected without the resolution and discrimination provided by SAMP-Score, underscoring the platform's ability to separate true senescence from confounding cellular states. This work exemplifies how machine learning and quantitative imaging can be harnessed to solve long-standing problems in senescence research, moving the field beyond binary marker expression toward phenotype-driven classification. Beyond its immediate relevance for cancer therapy, SAMP-Score offers a broadly applicable framework for senescence-based screening efforts across biological contexts. DOI - https://doi.org/10.18632/aging.206333 Corresponding author - Cleo L. Bishop - c.l.bishop@qmul.ac.uk Abstract video - https://www.youtube.com/watch?v=qXI_KI3EgHE Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206333 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@Aging-US LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY — December 8, 2025 — A new #research paper was #published in Volume 17, Issue 11 of Aging-US on September 12, 2025, titled “Infusion of blood from young and old mice modulates amyloid pathology.” This study was led by co-first authors Matias Pizarro from Universidad Adolfo Ibáñez and Ruben Gomez-Gutierrez from The University of Texas Health Science Center at Houston, alongside corresponding authors Claudia Duran-Aniotz from Universidad Adolfo Ibáñez and Rodrigo Morales from The University of Texas Health Science Center at Houston and Universidad Bernardo O'Higgins. The goal was to investigate how blood from young and old mice influences Alzheimer's-related changes in a transgenic mouse model. The findings indicate that age-dependent circulating factors can either worsen or mitigate brain changes associated with dementia, highlighting blood and its components as potential therapeutic targets. Alzheimer's disease is a progressive neurodegenerative disorder characterized by misfolded amyloid proteins, inflammation, and gradual cognitive decline, with aging as its main risk factor. In this work, whole blood from young adult or very old wild-type mice was repeatedly infused into Tg2576 mice, a well-established model of amyloid accumulation and memory impairment. Over several months, recipient mice received 30 weekly blood infusions, followed by behavioral testing and detailed neuropathological analyses. “Tg2576 mice express the human APP harboring the Swedish mutation.” Mice that received blood from old donors performed worse in both short- and long-term spatial memory tasks than mice infused with young blood, suggesting that aged blood contains factors that impair cognition. When the team examined brain tissue, they found more cortical amyloid deposits detected by a specific antibody in mice treated with old blood, while overall amyloid levels measured biochemically did not change, suggesting differences in plaque type or compactness rather than total amount. The expression of amyloid precursor protein in the brain was also higher after old-blood infusion, which may partly explain the shift in amyloid pathology.​ Despite these changes in plaques and memory, classical markers of astrocyte activation, a sign of brain inflammation, did not differ between groups, pointing to more subtle molecular shifts. A broad proteomic analysis of brain samples revealed dysregulation of proteins involved in synapse formation, calcium signaling, and the endocannabinoid system, pathways important for neuronal communication and plasticity. Among them, the calcium channel–related protein CACNA2D2 and the signaling protein BRAF were increased in mice that received old blood, confirming that aged blood circulation can reshape key signaling networks linked to neuronal function and degeneration. Overall, this study supports the idea that blood is not just a passive carrier but a powerful modulator of brain health during aging and disease. While young blood has been associated in previous work with improved synaptic function and reduced amyloid and tau changes, this study emphasizes the harmful impact of old blood, particularly on cortical amyloid patterns and memory. The identification of CACNA2D2 and BRAF as potential mediators of these effects suggests new avenues for targeting blood-borne factors or downstream brain pathways to slow or modify Alzheimer's-related decline. DOI - https://doi.org/10.18632/aging.206319 Corresponding authors - Claudia Duran-Aniotz - Claudia.Duran@uai.cl, and Rodrigo Morales - Rodrigo.MoralesLoyola@uth.tmc.edu Abstract video - https://www.youtube.com/watch?v=zsBDSAipH3w To learn more about the journal, visit https://www.Aging-US.com​​. MEDIA@IMPACTJOURNALS.COM

Baseline Craving Strength as a Prognostic Marker of Benefit from Smartphone App-Based Mindfulness Training for Smoking CessationIn this episode, Dr. Jud explores cutting-edge research into how baseline craving strength influences the effectiveness of smartphone app-based mindfulness training for smoking cessation. Discover how mindfulness-based programs help smokers reduce their reliance on cigarettes by disrupting the association between cravings and smoking. We discuss the role of craving strength as a potential marker for personalized treatment, key findings from the study, and implications for future smoking cessation strategies.Reference: Roos, C. R., Brewer, J. A., O'Malley, S. S., & Garrison, K. A. (2019). Baseline Craving Strength as a Prognostic Marker of Benefit from Smartphone App-Based Mindfulness Training for Smoking Cessation. Mindfulness, 10, 2165–2171. DOI: 10.1007/s12671-019-01188-6.Let's connect on Instagram

ECMO is the topic of this week's episode of Pediheart. We speak with Assistant Professor of Pediatrics and cardiac critical care specialist at Northwell Health, Dr. Ivana Capin about a recent ELSO database study she conducted to assess outcomes in single ventricle patients who were treated with ECMO prior to single ventricle palliation. What factors were associated with worse overall outcomes? Can this therapy be used to stabilize the HLHS patient with an intact atrial septum? Why have outcomes for this high risk patient group not appreciably improved in the recent decade? How can these data improve prognostic clarity when speaking with families in this difficult situation.Also joining us briefly is Associate Professor of Pediatrics at the Icahn School of Medicine at Mount Sinai, Dr. Scott Aydin to discuss his co-author and mentor, Dr. George Ofori-Amanfo as we approach the 4th anniversary of his untimely and tragic passing. DOI: 10.1017/S1047951125001386

In this episode of the Epigenetics Podcast, we talked with Fides Zenk from the École polytechnique fédérale de Lausanne about her work on transgenerational inheritance in Drosophila and brain organoids for human development insights. Dr. Zenk begins by sharing her journey into the field of biology, revealing her childhood fascination with nature and the intricate details of plant development. Her transition from an interest in ecology to a deep dive into molecular biology and gene regulation lays the groundwork for understanding her current research focus. We explore how her early experiences continue to shape her scientific curiosity, particularly her passion for studying cellular changes over time during embryonic development. As the conversation progresses, Dr. Zenk paints a vivid picture of her work at EPFL, where she combines functional genomics, chromatin profiling, and molecular biology techniques. She elaborates on her initial research during her PhD with Nicola Iovino, where she investigated the transgenerational inheritance of histone modifications in Drosophila. This discussion includes fascinating insights into how histone modifications can carry information across generations and their implications in gene expression regulation during early embryonic stages. Dr. Zenk also provides a glimpse into her postdoctoral work with Barbara Treutlein, where she shifted focus to human models and quantitative analysis using brain organoids. This segment of the episode reveals her commitment to translating molecular mechanisms to human health, especially in understanding the intricacies of brain development and neurogenesis. She describes how her team mapped dynamic changes in histone modifications during critical developmental stages, integrating various data modalities to build an intricate developmental atlas.   References Zenk F, Loeser E, Schiavo R, et al. Germ line-inherited H3K27me3 restricts enhancer function during maternal-to-zygotic transition. Science (New York, N.Y.). 2017 Jul;357(6347):212-216. DOI: 10.1126/science.aam5339. PMID: 28706074. Zenk F, Zhan Y, Kos P, et al. HP1 drives de novo 3D genome reorganization in early Drosophila embryos. Nature. 2021 May;593(7858):289-293. DOI: 10.1038/s41586-021-03460-z. PMID: 33854237; PMCID: PMC8116211. Zenk F, Fleck JS, Jansen SMJ, et al. Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems. Nature Neuroscience. 2024 Jul;27(7):1376-1386. DOI: 10.1038/s41593-024-01652-0. PMID: 38914828; PMCID: PMC11239525. Related Episodes The Role of Small RNAs in Transgenerational Inheritance in C. elegans (Oded Rechavi) Mapping the Epigenome: From Arabidopsis to the Human Brain (Joseph Ecker) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

The research and real talk keep rolling in! Join Jenny and John yet again as they dive into some new revelations on creatine, amino acids, and (love it or not) artificial intelligence. Staying up to date with new information is critical, but so is understanding how, if, and when to apply it!References: Xu C, Bi S, Zhang W, Luo L. The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis. Front Nutr. 2024 Jul 12;11:1424972. doi: 10.3389/fnut.2024.1424972. Erratum in: Front Nutr. 2025 Feb 17;12:1570800. doi: 10.3389/fnut.2025.1570800. PMID: 39070254; PMCID: PMC11275561.Aileen H. Lee, Lucie Orliaguet, Yun-Hee Youm, Rae Maeda, Tamara Dlugos, Yuanjiu Lei, Daniel Coman, Irina Shchukina, Prabhakar Sairam Andhey, Steven R. Smith, Eric Ravussin, Krisztian Stadler, Bandy Chen, Maxim N. Artyomov, Fahmeed Hyder, Tamas L. Horvath, Marc Schneeberger, Yuki Sugiura, Vishwa Deep Dixit. Cysteine depletion triggers adipose tissue thermogenesis and weight loss. Nature Metabolism, 2025; 7 (6): 1204 DOI: 10.1038/s42255-025-01297-8Jeanette A.I. Johnson, Daniel R. Bergman, Heber L. Rocha, David L. Zhou, Eric Cramer, Ian C. Mclean, Yoseph W. Dance, Max Booth, Zachary Nicholas, Tamara Lopez-Vidal, Atul Deshpande, Randy Heiland, Elmar Bucher, Fatemeh Shojaeian, Matthew Dunworth, André Forjaz, Michael Getz, Inês Godet, Furkan Kurtoglu, Melissa Lyman, John Metzcar, Jacob T. Mitchell, Andrew Raddatz, Jacobo Solorzano, Aneequa Sundus, Yafei Wang, David G. DeNardo, Andrew J. Ewald, Daniele M. Gilkes, Luciane T. Kagohara, Ashley L. Kiemen, Elizabeth D. Thompson, Denis Wirtz, Laura D. Wood, Pei-Hsun Wu, Neeha Zaidi, Lei Zheng, Jacquelyn W. Zimmerman, Jude M. Phillip, Elizabeth M. Jaffee, Joe W. Gray, Lisa M. Coussens, Young Hwan Chang, Laura M. Heiser, Genevieve L. Stein-O'Brien, Elana J. Fertig, Paul Macklin. Human interpretable grammar encodes multicellular systems biology models to democratize virtual cell laboratories. Cell, 2025; DOI: 10.1016/j.cell.2025.06.048

Gina M. Piscitello, MD, and Katrina E. Hauschildt, PhD, BCPA, join CHEST® Journal Podcast Moderator Gretchen Winter, MD, to discuss their research into the ways that and extent to which hospital policies influence clinician approaches to decisions to withhold or withdraw life-sustaining treatment among patients admitted to an ICU.  DOI: 10.1016/j.chest.2025.06.036 Disclaimer: The purpose of this activity is to expand the reach of CHEST content through awareness, critique, and discussion. All articles have undergone peer review for methodologic rigor and audience relevance. Any views asserted are those of the speakers and are not endorsed by CHEST. Listeners should be aware that speakers' opinions may vary and are advised to read the full corresponding journal article(s) for complete context. This content should not be used as a basis for medical advice or treatment, nor should it substitute the judgment used by clinicians in the practice of evidence-based medicine. 

Kristen R. Mathias, MD, MHS, joins CHEST® Journal Podcast Moderator Gretchen Winter, MD, to discuss her research into the ways patients with sarcoidosis describe their experiences with the disease, how they are impacted by uncertainty around sarcoidosis management, and the challenges they face in receiving care.   DOI: 10.1016/j.chest.2025.06.025 Disclaimer: The purpose of this activity is to expand the reach of CHEST content through awareness, critique, and discussion. All articles have undergone peer review for methodologic rigor and audience relevance. Any views asserted are those of the speakers and are not endorsed by CHEST. Listeners should be aware that speakers' opinions may vary and are advised to read the full corresponding journal article(s) for complete context. This content should not be used as a basis for medical advice or treatment, nor should it substitute the judgment used by clinicians in the practice of evidence-based medicine. 

Welcome to the Choosing Wisely Campaign series! This is the fifth and final episode of our 5-part series exploring the ABIM Foundation's Choosing Wisely Lists. This campaign aims to promote conversations between clinicians and patients to avoid unnecessary medical tests, treatments, and procedures. Our last case-based episode focuses on a school-aged male presenting with new-onset enuresis. After a discussion of the differential diagnosis and evidence-based evaluation strategies, we apply recommendations from multiple AAP Choosing Wisely lists to create a care plan that is safe, resource-conscious, and child-centered. Throughout this episode, we'll highlight how ethical care principles—beneficence, nonmaleficence, autonomy, and justice—guide high-value decision-making and help us avoid unnecessary imaging, laboratory studies, and interventions that add cost without improving outcomes. This familiar case in pediatrics is worthy of a rewind to relisten to a throwback episode that will reinforce your skills and emphasize the clinical diagnosis and management without added diagnostics, referrals, or medications.  This case closes out our series on Choosing Wisely in Pediatrics, but the principles we've explored should continue to inform your practice every day. If you missed earlier episodes, rewind to learn more about the campaign's background and listen to cases on fever and cough, gastroenterology presentations, and more.   Series Learning Objectives: Introduction to the Choosing Wisely Campaign: Understand the origins, historical precedent, and primary goals of the campaign. Case-Based Applications: Explore five common presentations in primary and acute care pediatrics, applying concepts from various Choosing Wisely lists to guide management and resource stewardship. Effective Communication: Learn strategies for engaging in tough conversations with parents and colleagues to create allies and ensure evidence-based practices are followed. Modified rMETRIQ Score: 15/15 What does this mean?   Competencies: AACN Essentials: 1: 1.1 g; 1.2 f; 1.3 d, e 2: 2.1 d, e; 2.2 g; 2.4 f, g; 2.5 h, i, j, k 7: 7.2 g, h, k 9: 9.1i, j; 9.2 i, j; 9.3 i, k NONPF NP Core Competencies: 1: NP 1.1h; NP 1.2 k, m; NP 1.3 f, j, h 2: NP 2.1 j, g; NP 2.2 k, n; NP 2.4 h, i; NP 2.5 k, l, m, n, o 7: NP 7.2 m 9: NP 9.1 m, n; NP 9.2 n; NP 9.3 p References: AAP Section on Emergency Medicine & Canadian Association of Emergency Physicians. (2022). Five things physicians and patients should question. Retrieved from https://downloads.aap.org/AAP/PDF/Choosing%20Wisely/CWEmergencyMedicine.pdf AAP Section on Gastroenterology, Hepatology, and Nutrition. (2023). Five things physicians and patients should question. https://downloads.aap.org/AAP/PDF/Choosing%20Wisely/CWGastroenterology.pdf AAP Section on Urology. (2022). Five things physicians and patients should question. Retrieved from https://downloads.aap.org/AAP/PDF/Choosing%20Wisely/CWUrology.pdf Daniel, M., Szymanik-Grzelak, H., Sierdziński, J., Podsiadły, E., Kowalewska-Młot, M., & Pańczyk-Tomaszewska, M. (2023). Epidemiology and Risk Factors of UTIs in Children-A Single-Center Observation. Journal of personalized medicine, 13(1), 138. https://doi.org/10.3390/jpm13010138 McMullen, P.C., Zangaro, G., Selzer, C., Williams, H. (2026). Nurse Practitioner Claims and the National Practitioner Data Bank: Trends, Analysis, and Implications for Nurse Practitioner Education and Practice. Journal for Nurse Practitioners, 22(1), p. 105569, https://doi-org.proxy.lib.duke.edu/10.1016/j.nurpra.2025.105569 Tabbers, M. M., DiLorenzo, C., Berger, M. Y., Faure, C., Langendam, M. W., Nurko, S., Staiano, A., Vandenplas, Y., Benninga, M. A., European Society for Pediatric Gastroenterology, Hepatology, and Nutrition, & North American Society for Pediatric Gastroenterology (2014). Evaluation and treatment of functional constipation in infants and children: evidence-based recommendations from ESPGHAN and NASPGHAN. Journal of pediatric gastroenterology and nutrition, 58(2), 258–274. https://doi.org/10.1097/MPG.0000000000000266 UCSF Benioff Children's Hospitals. (n.d.). Constipation & urologic problems. https://www.ucsfbenioffchildrens.org/conditions/constipation-and-urologic-problems Vaughan, D. (2015). The Challenger Launch Decision: Risky Technology, Deviance, and Culture at NASA. University of Chicago Press. DOI: 10.7208/chicago/9780226346960.001.0001 Wilbanks, Bryan A. PhD, DNP, CRNA. Evaluation of Methods to Measure Production Pressure: A Literature Review. Journal of Nursing Care Quality 35(2):p E14-E19, April/June 2020. | DOI: 10.1097/NCQ.0000000000000411

What's the episode about? In this episode, hear Professor Douglas Davies on thedevelopment of death studies, ‘words against death', the ‘dividual', religion, ‘sacred secrets', the ‘opacity of the self' and the ‘curated everything', keeping a dream diaries since 1979, the over-optimism of posthumanism, wealth inequality, & the privilege of intellectuals as ‘people who think'.Who is Douglas? This introduction to Douglas Davies was written by DrGeorgina Robinson, who awarded Douglas with the Lifetime Achievement Award at the 2025 Death, dying and Disposal Conference in Utrecht, the Netherlands. Douglas Davies is a name known to all who work in theinterdisciplinary field of Death Studies. From early career scholars, fresh in the field, through to senior colleagues who have themselves deeply influenced the field, the stories that people tell of their experiences of Douglas are always warm and encouraging, yet unique to the individual: the time and careDouglas gives to all who encounter him is a true testament of his character.  As a founding member of ASDS and editorial board member ofMortality Douglas has always offered a home to Death Studies scholars, having hosted numerous Death Studies events, including the International Conference onthe Social Context of Death, Dying, and Disposal and the inaugural International Symposium of the Death Online Research Network (DORS#1), as well as events for funerary professionals, including numerous Summer Schools of theNational Association of Funeral Directors.  Alongside these external events, Douglas has also welcomedcountless students, researchers, and professional colleagues to Durham during his time as Director of Durham University's Centre for Death and Life Studies through visiting professorships, library scholarships to work in the Archivesof the Cremation Society of Great Britain, alongside conferences hosted by the Centre. What is unique about Douglas is that despite his countless works whichhave deeply influenced scholarly thinking within the field, more often than not, it is a conversation or engagement with him that sticks with Death Studies scholars: his kindness and encouraging nature are second-to-none.  Nevertheless, the significant impact that his countlessworks have had – both academically and practically, with his work impacting policy changes and the funeral sector itself – must not be understated (e.g., Mors Britannica, 2015; Death, Ritual and Belief, 3 editions 1997, 2002, 2017;Natural Burial, 2012; A Brief History of Death, 2005; Theology of Death, 2008). Significantly, 2025 marks 50 years of Douglas's career in academia: how fitting that the association he was formative in establishing would award him with thehonour of Lifetime Achievement Award this year. How do I cite the episode in my research and reading lists? To cite this episode, you can use the following citation: Davies, D. (2025) Interview on The Death StudiesPodcast hosted by Michael-Fox, B. and Visser, R. Published 1 December 2025.Available at: www.thedeathstudiespodcast.com, DOI: 10.6084/m9.figshare.30752183 What next?Check out more episodes or find out more about the hosts! Gota question? Get in touch.

In the last ten years, 'diagnostic stewardship' has emerged as a core principle of good clinical practice whose implementation impacts both the individual patient and public health at large. In this episode of Communicable, hosts Angela Huttner and Annie Joseph invite two experts in the field, Daniel Morgan (Maryland, USA) and Valerie Vaughn (Utah, USA), to discuss diagnostic stewardship in the context of infectious diseases, hospital medicine, and healthcare in general. Other topics covered include practical interventions for better testing practices and the role of artificial intelligence in the future of diagnostics. The episode highlights how thoughtful, intentional diagnostic practices can enhance clinician workflows and improve patient outcomes.This episode is a follow-up from Morgan's recently published commentary in CMI Communications on diagnostic testing, and the need for evaluating its clinical impact [1]. The episode was peer reviewed by Özlem Türkmen Recen of Çınarcık State Hospital, Yalova, Türkiye. ReferencesBaghdadi JD & Morgan DJ. Diagnostic tests should be assessed for clinical impact. CMI Comms 2024. DOI: 10.1016/j.cmicom.2024.105010Further readingAdvani S and Vaughn VM. Quality Improvement Interventions and Implementation Strategies for Urine Culture Stewardship in the Acute Care Setting: Advances and Challenges. Curr Infect Dis Rep 2021. DOI: 10.1007/s11908-021-00760-3 Core Elements of Hospital Antibiotic Stewardship Programs, https://www.cdc.gov/antibiotic-use/hcp/core-elements/hospital.html Core Elements of Hospital Diagnostic Excellence (DxEx), https://www.cdc.gov/patient-safety/hcp/hospital-dx-excellence/index.htmlCosgrove SE & Srinivasan A. Antibiotic Stewardship: A Decade of Progress. Infect Dis Clin North Am 2023. DOI: 10.1016/j.idc.2023.06.003 Dik JH, et al. Integrated Stewardship Model Comprising Antimicrobial, Infection Prevention, and Diagnostic Stewardship (AID Stewardship). J Clin Microbiol 2017. DOI: 10.1128/jcm.01283-17Fabre V, et al. Principles of diagnostic stewardship: A practical guide from the Society for Healthcare Epidemiology of America Diagnostic Stewardship Task Force. Infect Control Hosp Epidemiol 2023. DOI: 10.1017/ice.2023.5 Huttner A, et al. Re: ‘ESR and CRP: it's time to stop the zombie tests' by Spellberg et al. CMI 2025. DOI: 10.1016/j.cmi.2024.09.016 Morgan DJ, et al. Diagnostic Stewardship—Leveraging the Laboratory to Improve Antimicrobial Use. JAMA 2017. DOI:  10.1001/jama.2017.8531 Messacar K, et al. Implementation of rapid molecular infectious disease diagnostics: the role of diagnostic and antimicrobial stewardship. J Clin Microbiol 2017. DOI: 10.1128/jcm.02264-16Messacar K, et al. Clinical and Financial Impact of a Diagnostic Stewardship Program for Children with Suspected Central Nervous System Infection. J Pediatr. 2022. DOI: 10.1016/j.jpeds.2022.02.002  Qian ET, et al. Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized With Acute Infection: The ACORN Randomized Clinical Trial. JAMA 2023. DOI: 10.1001/jama.2023.20583 Siontis KC et al. Diagnostic tests often fail to lead to changes in patient outcomes. J Clin Epidemiol 2014. DOI: 10.1016/j.jclinepi.2013.12.008Vaughn VM, et al. Antibiotic Stewardship Strategies and Their Association With Antibiotic Overuse After Hospital Discharge. Clin Infect Dis 2022. DOI: 10.1093/cid/ciac104Vaughn VM, et al. A Statewide Quality Initiative to Reduce Unnecessary Antibiotic Treatment of Asymptomatic Bacteriuria. JAMA Intern Med 2023. DOI: 10.1001/jamainternmed.2023.2749  

In dieser Sitzung verlassen wir den Bereich von Syntax und Morphologie und wenden uns einem Feld zu, das in den kommenden Jahren sicher an Bedeutung gewinnen wird: der Multimodalität – mit besonderem Fokus auf Prosodie und Intonation. Wir beleuchten, wie bestimmte syntaktische Muster nicht nur durch Wortstellung, sondern auch durch ihre lautliche Realisierung Bedeutung tragen. Im Zentrum steht dabei der narrative Konnektor „und dann“ (sowie Variationen wie „und bald darauf“) und die Frage, wie diese Strukturen speziell beim Erzählen und Erklären eingesetzt werden. Zudem möchte ich zeigen, wie sich Generative KI (GenKI) nutzen lässt, um spezifische gesprochensprachliche Phänomene in Videos (z. B. aus der Sendung „Dingsda“) effizient zu identifizieren.Präsentation (*.pdf): Alexander Lasch. 2025. Konstruktionsgrammatik. Zenodo. DOI: ⁠https://doi.org/10.5281/zenodo.17370032⁠. Videoaufzeichnungen: ⁠⁠⁠⁠⁠⁠⁠⁠https://youtube.com/@AlexanderLasch⁠⁠⁠⁠⁠⁠⁠⁠. Informationen & Material zu allen Vorlesungen: ⁠⁠⁠⁠⁠⁠⁠⁠https://kurzelinks.de/fl7f⁠⁠⁠⁠⁠⁠⁠⁠. Worksheet zu den Vorlesungen: ⁠⁠https://kurzlinks.de/WorksheetVorlesungen⁠⁠. Intro: "Reflections" von Scott Holmes (CC BY via ⁠⁠⁠⁠⁠⁠FMA⁠⁠⁠⁠⁠⁠).#Linguistik #OER #Sprache #Sprachwissenschaft #Grammatik #Konstruktionsgrammatik

Urban areas represent both opportunities and risks for animals, and they adapt their behaviour in many ways to cope with this fast-paced lifestyle. Now, a new study has detailed how urban wall lizards in Croatia have richer social lives than their rural counterparts. Then we chat about a listener-submitted story detailing wild lizards eating pizza. Become a Patreon: https://www.patreon.com/herphighlights Merch: https://www.redbubble.com/people/herphighlights/shop Full reference list available here: http://www.herphighlights.podbean.com Main Paper References: Maune AL, Wittenbreder T, Lisičić D, Caspers BA, Camerlenghi E, Damas-Moreira I. 2025. City lizards are more social. Biology Letters 21:20250326. DOI: 10.1098/rsbl.2025.0326. Other Mentioned Papers/Studies: Dendi, D., Segniagbeto, G. H., Meek, R., & Luiselli, L. (2023). Opportunistic foraging strategy of rainbow lizards at a seaside resort in Togo. African Journal of Ecology, 61(1), 226-227. Editing and Music: Intro/outro – Treehouse by Ed Nelson Species Bi-week theme – Michael Timothy Other Music – The Passion HiFi, https://www.thepassionhifi.com  

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Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-460 Overview: Join us as we discuss how frequently patients with stable hypertension should monitor their blood pressure at home. Hear insights from two trials to help you provide evidence-based, cost-conscious guidance—reducing unnecessary alarms while supporting better long-term management. Episode resource links: Rose, Francesa; Stevens, Richard S.a; Morton, Kate S.b; Yardley, Lucyc; McManus, Richard J.a,d. How often should self-monitoring of blood pressure be repeated? A secondary analysis of data from two randomized controlled trials. Journal of Hypertension ():10.1097/HJH.0000000000004123, August 20, 2025. | DOI: 10.1097/HJH.0000000000004123 Guest: Robert A. Baldor MD, FAAFP   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-460 Overview: Join us as we discuss how frequently patients with stable hypertension should monitor their blood pressure at home. Hear insights from two trials to help you provide evidence-based, cost-conscious guidance—reducing unnecessary alarms while supporting better long-term management. Episode resource links: Rose, Francesa; Stevens, Richard S.a; Morton, Kate S.b; Yardley, Lucyc; McManus, Richard J.a,d. How often should self-monitoring of blood pressure be repeated? A secondary analysis of data from two randomized controlled trials. Journal of Hypertension ():10.1097/HJH.0000000000004123, August 20, 2025. | DOI: 10.1097/HJH.0000000000004123 Guest: Robert A. Baldor MD, FAAFP   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  

Why is a broad approach that works with iPSC-derived cardiomyocytes so important to understanding molecular mechanisms underlying calcium homeostasis and arrhythmias? In this episode, Associate Editor Dr. Petra Kleinbongard (University of Duisburg-Essen) interviews author Dr. Katrin Streckfuss-Bömeke (University Medical Center Göttingen) and expert Dr. Melanie Paillard (Université Claude Bernard Lyon 1) about the new study by Ajmail et al. While arrhythmias in calcium transients are easy to detect by human perception, quantifying arrhythmias in a computer-readable manner is often difficult. To tackle the challenge, the authors developed an open-source program called Arrhythpy that quantifies and classifies confocal microscopy-based Fluo-4 Ca2+ transients to generate a measure of arrhythmia. What is unique about Arrhythpy is that it directly measures the shape and frequency of transients. The program includes two parts: frequency profiling using a method called wavelet transformation, and measuring transient peak shape using a method called autocorrelation function. After combining these measurements, Arrhythpy classifies each transient into one of 6 different subgroups. No specialty training is needed, and no specialized platforms are required to use Arrhythpy. The program can be used with different microscopes, cell types, and calcium dyes. What is the utility of Arrhythpy beyond the arrhythmia field? Listen now to find out.   Karim Ajmail, Charlotte Brand, Thomas Borchert, Benjamin Meder, Sabine Rebs, Katrin Streckfuss-Bömeke Arrhythpy: An Automated Tool to Quantify and Classify Arrhythmias in Ca2+ Transients of iPSC-Cardiomyocytes Am J Physiol Heart Circ Physiol, published September 15, 2025. DOI: 10.1152/ajpheart.00414.2025

A Systematic Review and Meta-Analysis of Psychosocial Interventions for Persons with Comorbid Anxiety and Substance Use DisordersIn this episode, Dr. Jud dives into the comprehensive findings of a meta-analysis on psychosocial interventions for individuals facing the dual challenge of anxiety and substance use disorders. This research sheds light on the efficacy of treatments like cognitive behavioral therapy (CBT), motivational interviewing, and integrated care in addressing anxiety, alcohol consumption, and substance use. Join us as we explore the transformative potential of these interventions, the complexities of treating co-occurring conditions, and the pressing gaps in research for broader substance categories like opioids and methamphetamines.Reference: Nardi, W. R., Kelly, P., Roy, A., Becker, S., Brewer, J., & Sun, S. (2024). A systematic review and meta-analysis of psychosocial interventions for persons with comorbid anxiety and substance use disorders. Journal of Substance Use and Addiction Treatment, 165, 209442. DOI: 10.1016/j.josat.2024.209442Let's connect on Instagram

This week we review the topic of mitral annular disjunction ("MAD") and the possible association with ventricular arrhythmia or sudden death in the connective tissue disease patient. Is there a 'cut off' distance above which patients deserve more significant arrhythmia surveillance? What is the best way to measure the MAD distance? Can patients with low MAD distances have lower degrees or even no arrhythmic surveillance? How often should this distance be measured on CMR and can an echo measurement provide similar data? Dr. Daniel Castellanos, the first author of this work and Assistant Professor of Pediatrics at Harvard Medical School shares his deep insights this week.DOI: 10.1016/j.jocmr.2025.101954

Regional anesthesia, typically with a spinal or epidural, haslong been favored for cesarean births due in part to concerns about the effects that general anesthesia (GA) may have on newborns at delivery. However, data has shown that up to 1 in 6 women may experience pain with a “topped-off”labor epidural, during the cesarean. A new publication in the journal Anesthesia is now being interpreted as implying that general anesthesia may be a valid alternative electively. Is that what this new study found? Has GA been linked to postpartum depression? What about later child neurodevelopmental delays? This is a fascinating topic…Listen in for details. 1.     Langer, Sarah M.D.1; Lim, Grace M.D., M.Sc.2;Qiu, Yue M.D.3; Biaesch, Jingyuan D.O.4; Neuman, Mark D. M.D., M.Sc.5. NeonatalOutcomes with Regional versus General Anesthesia for Cesarean Delivery: AMeta-analysis of Randomized Controlled Trials. Anesthesiology():10.1097/ALN.0000000000005785, November 12, 2025. | DOI:10.1097/ALN.00000000000057852.     Guglielminotti J, Monk C, Russell MT, Li G.Association of General Anesthesia for Cesarean Delivery with PostpartumDepression and Suicidality. Anesth Analg. 2025 Sep 1;141(3):618-628. doi:10.1213/ANE.0000000000007314. Epub 2024 Dec 4. PMID: 39630595; PMCID:PMC12134152.3.     Chen, YC., Liang, FW., Tan, PH. et al.Association between general anesthesia for cesarean delivery and subsequentdevelopmental disorders in children: a nationwide retrospective cohort study.BMC Med 23, 119 (2025). https://doi.org/10.1186/s12916-025-03886-64.     https://www.pennmedicine.org/news/new-study-challenges-fears-about-general-anesthesia-during-c-section

This episode cuts through the noise and explains why creatine is one of the most effective, well-researched supplements for women, not just for building muscle, but for thinking sharper, recovering faster, and staying steady when life is heavy. We break down the physiology, the misconceptions, and the real-world benefits so you can use creatine with clarity and confidence.I used one main paper to research all the mechanistic stuff for this episode. It is free to access and it's AMAZING:Creatine Supplementation Beyond Athletics: Benefits of Different Types of Creatine for Women, Vegans, and Clinical Populations — A Narrative ReviewGutiérrez-Hellín J., Del Coso J., Franco-Andrés A., Gamonales J.M., Espada M.C., González-García J., López-Moreno M., Varillas-Delgado D.Nutrients (2025).PMCID: PMC11723027 | DOI: 10.3390/nu17010095Then some of the other studies I mentioned can be found here: 1. Single Dose Creatine Improves Cognitive Performance and Induces Changes in Cerebral High-Energy Phosphates During Sleep DeprivationGordji-Nejad A., Matusch A., Kleedörfer S., Patel H.J., Drzezga A., Elmenhorst D., Binkofski F., Bauer A.Scientific Reports (2024).PMCID: PMC10902318 | DOI: 10.1038/s41598-024-54249-9What it's aboutA high single dose of creatine helped offset the cognitive decline and metabolic stress caused by sleep deprivation, temporarily boosting brain energy systems and mental performance.2. Creatine Promotes Endometriosis Progression by Inducing M2 Polarization of Peritoneal MacrophagesChen S.-M., Liu Y.-K., Ma X.-Q., Wei C.-Y., Li M.-Q., Zhu X.-Y.Reproduction (2024).DOI: 10.1530/REP-24-0278 | PMID: 39679878What it's aboutThis study found that creatine can shift peritoneal macrophages into an M2, pro-growth state, which may accelerate inflammation, angiogenesis, and lesion development in endometriosis.3. Effects of Long-Term Low-Dose Dietary Creatine Supplementation in Older WomenLobo D.M., Tritto A.C., da Silva L.R., de Oliveira P.B., Benatti F.B., Roschel H., Nieß B., Gualano B., Pereira R.M.R.Experimental Gerontology (2015).DOI: 10.1016/j.exger.2015.07.012 | PMID: 26192975What it's aboutA year of very low-dose creatine (1 g/day) was safe but too small a dose to produce measurable changes in bone health, lean mass, or muscle function in postmenopausal women.

Podcast Family, we have covered the subject of Measles previously on this show (links below). Those episodes were a preview of what has now been released ahead of print as a narrative review in the Green Journal! In this episode, we will summarize the KEY points of measles infection in pregnancy and re-state the “rule of 4” and the importance of the number 10 regarding this.1. Feb 24, 2025: Measles 101: https://open.spotify.com/episode/4lXrpqKTJPdDcTXPxpEmcb2. April 27, 2019: Measles!! ACOG Practice Advisory: https://creators.spotify.com/pod/profile/dr-hector-chapa/episodes/MEASLES---ACOG-practice-advisory-e3s1p43. Joseph, Naima T. MD, MPH. Measles in Pregnancy: Clinical Considerations and Challenges. Obstetrics & Gynecology ():10.1097/AOG.0000000000006126, November 14, 2025. | DOI: 10.1097/AOG.0000000000006126

Research from Asian geckos generally suggests that sticky pads are used for smooth surfaces, while claws help grip onto rougher surfaces like wood and rocks. But a new study using Australian geckos is has turned that paradigm upside-down. Then we talk about a brand new species of frog described from the mountains of central China. Become a Patreon: https://www.patreon.com/herphighlights Merch: https://www.redbubble.com/people/herphighlights/shop Full reference list available here: http://www.herphighlights.podbean.com Main Paper References: Pillai RR, Riedel J, Wirth W, Allen-Ankins S, Nordberg E, Edwards W, Schwarzkopf L. 2025. What's the point? The functional role of claws in pad-bearing taxa (Gekkota: Diplodactylidae). Proceedings of the Royal Society B: Biological Sciences 292:20251362. DOI: 10.1098/rspb.2025.1362. Species of the Bi-Week: Li S, Shi S, Liu J, Zhao J, Gao S, Wang B. 2025. A new species of the Boulenophrys (Anura, Megophryidae) from Hubei, China. Zoosystematics and Evolution 101:1213–1226. DOI: 10.3897/zse.101.155859. Other Mentioned Papers/Studies: GEORGALIS, G. L., & JONES, M. E. (2025). A new peculiar early diverging caenophidian snake (Serpentes) from the late Eocene of Hordle Cliff, England. Comptes Rendus Palevol, 24(25), 505-530. Editing and Music: Intro/outro – Treehouse by Ed Nelson Species Bi-week theme – Michael Timothy Other Music – The Passion HiFi, https://www.thepassionhifi.com

Well, from time to time we cover RANDOM tidbits of information which cover RANDOM questions and/or RANDOM patient care issues that we encounter. In this episode we will cover one OB issue related to recurrent pregnancy loss, one GYN issue related to unilateral breast swelling in a patient with SLE, and one RANDOM life perspective response from a mock interview that I participated in for a residency candidate. Listen in fordetails!1.     Viviana DO; Giugni, Claudio Schenone MD; Ros, Stephanie T. MD, MSCI. Factor V and recurrent pregnancy loss: de Assis, Evaluation of Recurrent Pregnancy Loss. Obstetrics & Gynecology 143(5):p 645-659, May 2024. | DOI: 10.1097/AOG.0000000000005498Unilateral Breast Swelling with SLE: 2.     Voizard B, Lalonde L, Sanchez LM, et al. LupusMastitis as a First Manifestation of Systemic Disease: About Two Cases With a Review of the Literature. European Journal of Radiology. 2017;92:124-131. doi:10.1016/j.ejrad.2017.04.023.3.     Kinonen C, Gattuso P, Reddy VB. Lupus Mastitis:An Uncommon Complication of Systemic or Discoid Lupus. The American Journal of Surgical Pathology. 2010;34(6):901-6. doi:10.1097/PAS.0b013e3181da00fb.4.      Summers TA, Lehman MB, Barner R, Royer MC. Lupus Mastitis: A Clinicopathologic Review and Addition of a Case. Advances in Anatomic Pathology.2009;16(1):56-61. doi:10.1097/PAP.0b013e3181915ff7.5.     Jiménez-Antón A, Jiménez-Gallo D,Millán-Cayetano JF, Navarro-Navarro I, Linares-Barrios M. Unilateral Lupus Mastitis.Lupus. 2023;32(3):438-440. doi:10.1177/09612033221151011.STRONG COFFEE PROMO: 20% Off Strong Coffee Company https://strongcoffeecompany.com/discount/CHAPANOSPINOBG