Podcasts about DOI

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Best podcasts about DOI

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Latest podcast episodes about DOI

Herpetological Highlights
116 The Unfamiliar Scent of Death

Herpetological Highlights

Play Episode Listen Later Jun 29, 2022 27:46


Can the smell of predators put lizards off their lunch?  Become a Patreon: https://www.patreon.com/herphighlights Full reference list available here: http://www.herphighlights.podbean.com Main Paper Reference: Webster C, Massaro M, Michael DR, Bambrick D, Riley JL, Nimmo DG. 2018. Native reptiles alter their foraging in the presence of the olfactory cues of invasive mammalian predators. Royal Society Open Science 5:180136. DOI: 10.1098/rsos.180136. Species of the Bi-Week: Oliver PM, Rittmeyer EN, Torkkola J, Donnellan SC, Dahl C, Richards SJ. 2020. Multiple trans-Torres Strait colonisations by tree frogs in the Litoria caerulea group, with the description of a new species from New Guinea. Australian Journal of Zoology 68:15. Other Mentioned Papers/Studies: Apfelbach R, Parsons MH, Soini HA, Novotny MV. (2015) Are single odorous components of a predator sufficient to elicit defensive behaviors in prey species? Frontiers in Neuroscience. 9, 263. (doi:10. 3389/fnins.2015.00263) Music: Intro/outro – Treehouse by Ed Nelson Species Bi-week theme – Mike Mooney

Let's talk e-cigarettes
June 2022 with Dr Francesca Pesola

Let's talk e-cigarettes

Play Episode Listen Later Jun 29, 2022 18:38


Jamie Hartmann-Boyce and Nicola Lindson discuss emerging evidence in e-cigarette research and interview Dr Francesca Pesola. In the June episode Jamie Hartmann-Boyce talks with Francesca Pesola from the Wolfson Institute of Population Health Queen Mary University of London Dr Francesca Pesola talks to Associate Professor Jamie Hartmann-Boyce about the results from the trial of e-cigarettes compared to nicotine patches for smoking cessation in pregnant women. Professor Tim Coleman discussed this study in our May 2021 podcast and the results have now been published in Nature Medicine, Hajek et al 2022 (DOI: 10.1038/s41591-022-01808-0). Dr Pesola outlines the need to identify smoking cessation aids to help women quit during pregnancy. Dr Pesola discusses the results of their randomised control trial of 1,140 participants comparing refillable e-cigarettes with nicotine patches in which pregnant women who smoke were randomized to e-cigarettes or nicotine patches. Dr Pesola reports that the unadjusted analysis of the primary outcome of validated quit rates at the end of pregnancy were not found to be significantly different between the e-cigarette and nicotine patch arms. However, Dr Pesola explains that some people in the study used non-allocated products, for example people in the nicotine patch group were also found to be using e-cigarettes. This meant that if they then quit you were not able to be sure whether the quitting behaviour was due to the nicotine patch or to the e-cigarette. The study team had anticipated this behaviour and pre-specified that they would exclude people who were abstinent and who had used non-allocated products. Dr Pesola reports that after doing this e-cigarettes were found to be more effective than patches. The safety profile was similar for both study products, however, low birthweight (

Lagrange Point
Episode 498 - Clean air, captured carbon and paper sensors

Lagrange Point

Play Episode Listen Later Jun 27, 2022 16:26


Where is the cleanest air on the planet? How do oceans help capture carbon from forest fires? Where does all that carbon go after a forest fire? How do you find the cleanest air, by measuring microbes. The southern ocean air is not polluted by aerosols or ice forming particles. The air above the Southern Ocean is clean and crisp with not much microbes in side it. How can you turn a paper into a simple carbon dioxide sensor? Matthew W. Jones, Alysha I. Coppola, Cristina Santín, Thorsten Dittmar, Rudolf Jaffé, Stefan H. Doerr, Timothy A. Quine. Fires prime terrestrial organic carbon for riverine export to the global oceans. Nature Communications, 2020; 11 (1) DOI: 10.1038/s41467-020-16576-z Hui Wang, Sergei I. Vagin, Bernhard Rieger, Alkiviathes Meldrum. An Ultrasensitive Fluorescent Paper-Based CO2 Sensor. ACS Applied Materials & Interfaces, 2020; 12 (18): 20507 DOI: 10.1021/acsami.0c03405

Bret Weinstein | DarkHorse Podcast
#132: 50 States not in a Roe (Bret Weinstein & Heather Heying DarkHorse Livestream)

Bret Weinstein | DarkHorse Podcast

Play Episode Listen Later Jun 26, 2022 89:44


In this 132nd in a series of live discussions with Bret Weinstein and Heather Heying (both PhDs in Biology), we discuss the state of the world through an evolutionary lens. This week, we discuss the overturning of Roe v. Wade, and how both individuals and political entities on both “sides” are responding to it. We discuss the implications of whether other organisms might use abortifacients, and how fuzzy categories are revealed with the discovery of a giant bacterium. We discuss whether twitter is sanctioning violence, while saying that they are doing the opposite. And we discuss the recent reveal that the CDC, despite seeming to claim the opposite for well over a year now, is now acknowledging that they have not been analyzing adverse events from the Covid vaccines. ***** Support the sponsors of the show: Thesis: personalized nootropics for motivation, creativity, confidence and more. To get your own customized Thesis starter kit, go online to takethesis.com/DARKHORSE, take the quiz, and use code DARKHORSE at checkout for 10% off your first box! BUBS Naturals: High-quality, sustainably sourced collagen protein, MCT oil, and more, from a company with a conscience. 20% of your order at https://www.bubsnaturals.com/?discount=DARKHORSE Farrow Life is a lard-based skincare company with products that nourish the skin without preservatives or added chemicals. Go to farrow.life/darkhorse for 20% off your first purchase; additional 15% off with a recurring subscription. ***** Our book, A Hunter-Gatherer's Guide to the 21st Century, is available everywhere books are sold, and signed copies are available here: https://darvillsbookstore.indielite.org Check out our store! Epic tabby, digital book burning, saddle up the dire wolves, and more: https://store.darkhorsepodcast.org Heather's newsletter, Natural Selections (subscribe to get free weekly essays in your inbox): https://naturalselections.substack.com Become a member of the DarkHorse LiveStreams, and get access to an additional Q&A livestream every month. Join at Heather's Patreon. Like this content? Subscribe to the channel, like this video, follow us on twitter (@BretWeinstein, @HeatherEHeying), and consider helping us out by contributing to either of our Patreons or Bret's Paypal. Looking for clips from #DarkHorseLivestreams? Check out our other channel:  https://www.youtube.com/channel/UCAWCKUrmvK5F_ynBY_CMlIA ***** Q&A Link: https://youtu.be/usP2D_qGUZs Mentioned in this episode: Alito Goes a Long Way: DarkHorse livestream #125, on SCOTUS, Roe and abortion, May 4, 2022: https://youtu.be/XTPba-Hz4gM Heying 2018. On Abortion: Time, Space, Error and Ethics. Areo: https://areomagazine.com/2018/08/24/on-abortion-time-space-error-and-ethics/ Volland et al 2022. A centimeter-long bacterium with DNA compartmentalized in membrane-bound organelles. Science 376, 1453–1458. DOI: 10.1126/science.abb3634 Less technical summary of the giant bacterium discovery, in Nature: https://doi.org/10.1038/d41586-022-01757-1 Guetzkow, for Children's Health Defense, 6/21/22: CDC Admits It Never Monitored VAERS for COVID Vaccine Safety Signals: https://childrenshealthdefense.org/defender/cdc-vaers-covid-vaccine-safety/ Vaccine Adverse Event Reporting System (VAERS)Standard Operating Procedures for COVID-19, from the CDC, 2021 (updated 2022: https://www.cdc.gov/vaccinesafety/pdf/VAERS-v2-SOP.pdf Support the show

Leadership Today Podcast
Episode 143 - Showing Stress Leads to Support

Leadership Today Podcast

Play Episode Listen Later Jun 24, 2022 3:18


SUMMARY Research demonstrates that showing stress can lead to greater support from others.   TRANSCRIPT Welcome to episode 143 of the Leadership Today podcast where each week we bring research to life in your leadership. This week we explore at how showing stress can lead to greater support from others. Have you ever thought about why we demonstrate stress? Surely showing signs of stress to others puts us at a disadvantage. Why would we want to show weakness? And why do even the most accomplished professionals still show signs of stress? Researchers from Nottingham Trent University and the University of Portsmouth recently reinforced what we already know - people are pretty good at identifying stress in others. As people feel more stressed, others notice more stress in them - there's nothing revolutionary about that finding. However they took it one step further to examine the impact of those stress signs on others. It turns out that people reacted more positively to those who demonstrated signs of stress than those who didn't. Those who demonstrated signs of stress were seen as more likeable. So why might that be the case? The researchers highlighted that human beings are largely a cooperative species - we survive and thrive by helping each other. They theorised that an honest sign of weakness may show that we are willing to cooperate, or at least that we're not a threat.  All of this builds on a body of research that suggests being more emotionally expressive helps us to be well-liked by others and results in more positive social interactions.  Here are some thoughts based on this research that you can take and apply: Show your emotions - the goal of emotional intelligence isn't to become emotionless. In fact, showing no emotion may lead us to be seen as competitive or difficult to read. Encourage others - when someone does show signs of stress, provide them with some support and encouragement. Imagine yourself in that situation and how much a kind word would help. Don't overdo it - one of the worst ways to start a speech is saying “I'm really nervous”. People want someone they can relate to, but also someone that they can be confident in. Rewrite your emotions - if you feel stressed or nervous, reframe that as wanting to do a good job or being excited to present work that matters to you. Stress isn't necessarily bad. We can use our own and others' stress as a way to build connections and cooperation.   REFERENCE Jamie Whitehouse, Sophie J. Milward, Matthew O. Parker, Eithne Kavanagh, Bridget M. Waller. Signal value of stress behaviour. Evolution and Human Behavior, 2022; DOI: 10.1016/j.evolhumbehav.2022.04.001

Herpetological Highlights
115 Tag! You're Envenomated

Herpetological Highlights

Play Episode Listen Later Jun 24, 2022 26:51


Venoms are complex, and researchers are constantly discovering new intriguing uses. But this episode we look at a fascinating new venom use for the snakes themselves. Become a Patreon: https://www.patreon.com/herphighlights Full reference list available here: http://www.herphighlights.podbean.com Main Paper References: Saviola AJ, Chiszar D, Busch C, Mackessy SP. 2013. Molecular basis for prey relocation in viperid snakes. BMC Biology 11:20. DOI: 10.1186/1741-7007-11-20. Other Mentioned Papers/Studies: Teshera MS, Clark RW, Wagler AE, Greenbaum E. 2021. Foraging and scavenging behaviour of the prairie rattlesnake (Crotalus viridis): no evidence that envenomation cues facilitate kleptoparasitism of struck prey. Amphibia-Reptilia:1–11. DOI: 10.1163/15685381-bja10073. Other Links/Mentions: Indian purple frog call from Thomas A, Suyesh R, Biju SD, Bee MA. 2014. Vocal behavior of the elusive purple frog of India (Nasikabatrachus sahyadrensis), a fossorial species endemic to the Western Ghats. PloS one, 9(2), p.e84809: https://en.wikipedia.org/wiki/File:Vocal-Behavior-of-the-Elusive-Purple-Frog-of-India-(Nasikabatrachus-sahyadrensis)-a-Fossorial-pone.0084809.s005.ogv Music: Intro/outro – Treehouse by Ed Nelson Species Bi-week theme – Mike Mooney Other Music – The Passion HiFi, www.thepassionhifi.com

Agents of Hope
"You can't hire knowledge, you must grow it" - Discussing EPs as change agents working with Educational Organisations with Dr Gavin Morgan

Agents of Hope

Play Episode Listen Later Jun 23, 2022 66:09


In this episode I chat with Gavin Morgan, an Educational Psychologist, Academic Tutor and member of the Scientific Pandemic Influenza Group, who helped the Government make evidence based decisions during the pandemic. It was fascinating conversation and explored the different types of role taken up by EPs as facilitators of change to outright advocates for change. References Gavin Morgan (2016) Organisational change: a solution-focused approach,Educational Psychology in Practice, 32:2, 133-144, DOI: 10.1080/02667363.2015.1125855https://www.theguardian.com/education/2020/jun/20/school-closures-will-trigger-uk-child-mental-health-crisishttps://www.theguardian.com/commentisfree/2020/jun/20/childrens-mental-health-will-suffer-irreparably-if-schools-dont-reopen-soonSupport the show

Indianz.Com
House Appropriations Subcommittee Approves Fiscal Year 2023 Interior-Environment Funding Bill

Indianz.Com

Play Episode Listen Later Jun 22, 2022 18:22


Appropriations Subcommittee Approves Fiscal Year 2023 Interior-Environment Funding Bill * The following contains portions of a June 21, 2022, press release from Rep. Betty McCollum (D-Minnesota). WASHINGTON, D.C. — The House Appropriations Subcommittee on Interior, Environment, and Related Agencies, of which Congresswoman Betty McCollum (MN-04) is Vice Chair, today approved by voice vote the subcommittee's Fiscal Year 2023 bill, which includes funding for programs within the Department of the Interior, the Environmental Protection Agency, and other agencies, including the Indian Health Service. The bill will next be considered by the full Appropriations Committee next week. In total, the bill includes $44.8 billion in regular appropriations, an increase of $6.8 billion – 18 percent – above the FY 2022 enacted level. There is also an additional $2.55 billion of funding provided under the fire suppression cap adjustment. The legislation also: Honors the federal government's responsibilities to Native American families by investing in tribal communities including through education and health care programs A summary of the fiscal year 2023 Interior, Environment, and Related Agencies bill is below. The text of the bill is here. Bill Summary: Department of the Interior (DOI) – The bill provides a total of $16.6 billion in discretionary appropriations for DOI, an increase of $2.1 billion above the FY 2022 enacted level. Of this amount, the bill includes: $171 million for the Historic Preservation Fund. Within this amount, the bill includes $82 million for State and Tribal Historic Preservation Offices, $38 million for Save America's Treasures competitive and project grants, $28 million for competitive grants to preserve the sites and stories of underrepresented community civil rights, and $10 million for grants to Historically Black Colleges and Universities. $4.4 billion for the Bureau of Indian Affairs, Bureau of Indian Education, and Office of the Special Trustee, an increase of $778 million above the FY 2022 enacted level. Within this amount, the bill includes: $2.2 billion for Bureau of Indian Affairs Operation of Indian Programs, an increase of $330 million above the FY 2022 enacted level. $50 million for Indian Land Consolidation, an increase of $43 million above the FY 2022 enacted level. $181 million for Bureau of Indian Affairs Construction, an increase of $34 million above the FY 2022 enacted level. $14 million for the Indian Guaranteed Loan Program, an increase of $2 million above the FY 2022 enacted level. $1.2 billion for Bureau of Indian Education Operation of Indian Programs, an increase of $175 million above the FY 2022 enacted level. $375 million to Bureau of Indian Education Construction, an increase of $111 million above the FY 2022 enacted level. Fully funds Contract Support Costs and Payments for Tribal Leases. $111 million for the Office of the Special Trustee, an increase of $2 million above the FY 2022 enacted level. $457 million for Departmental Offices, $55 million above the FY 2022 enacted level. Within this amount, the bill includes: $129.7 million for the Office of Insular Affairs, an increase of $7.8 million above the FY 2022 enacted level and $4 million. $45 million for the Energy Community Revitalization Program, an increase of $40 million above the FY 2022 enacted level. The principal focus in fiscal year 2023 is on hard rock mining. Related Agencies $8.1 billion for the Indian Health Service, an increase of $1.5 billion above the FY 2022 enacted level. $5.7 billion for Health Services, an increase of $1 billion above the FY 2022 enacted level. $1.3 billion for Health Facilities, an increase of $367 million above the FY 2022 enacted level. Fully funds Contract Support Costs and Payments for Tribal Leases. $207 million each for the National Endowment for the Arts and the

Herpetological Highlights
114 Not All Retics Are The Same

Herpetological Highlights

Play Episode Listen Later Jun 21, 2022 31:34


A phylogenetic paper focused episode looking at the longest snake of them all: Reticulated pythons. Are all reticulated pythons part of one big happy whole, or do the hundreds of islands they inhabit mean pythons represent just as many sub-species? Species of the Bi-week is a wonderfully lemon-soaked lizard. Become a Patreon: https://www.patreon.com/herphighlights Full reference list available here: http://www.herphighlights.podbean.com Main Paper References: Murray-Dickson G, Ghazali M, Ogden R, Brown R, Auliya M. 2017. Phylogeography of the reticulated python (Malayopython reticulatus ssp.): Conservation implications for the worlds' most traded snake species. PLOS ONE 12:e0182049. DOI: 10.1371/journal.pone.0182049. Species of the Bi-Week: Pavón-Vázquez CJ, Esquerré D, Fitch AJ, Maryan B, Doughty P, Donnellan SC, Keogh JS. 2022. Between a rock and a dry place: phylogenomics, biogeography, and systematics of ridge-tailed monitors (Squamata: Varanidae: Varanus acanthurus complex). Molecular Phylogenetics and Evolution 173:107516. DOI: 10.1016/j.ympev.2022.107516. Other Links/Mentions: Tom's appearance on BBC Springwatch: https://www.youtube.com/watch?v=PCP2w5CVbkY Music: Intro/outro – Treehouse by Ed Nelson Species Bi-week theme – Mike Mooney Other Music – The Passion HiFi, www.thepassionhifi.com

Lagrange Point
Episode 488 -Mysteries from the formation of our solar system

Lagrange Point

Play Episode Listen Later Jun 20, 2022 18:29


From cosmic rays in Antarctica, to chasing Eclipses to learn about stellar weather. Neutrinos are hard to track and detect, as are cosmic rays. Neutrinos suddenly coming out of Antarctica baffled scientists hunting for cosmic rays.  Underground glacial lakes, compacted snow, cosmic can help explain mysterious neutrino emissions. Tracking eclipses and gathering data over 20 years can help us understand stellar weather. By studying the Sun's corona, scientists can better understand the magnetic field and stellar weather. The sun changes activity over 11 year cycles, and it's magnetic field also rearranges itself from highly structured to loose and messy.   Ian M. Shoemaker, Alexander Kusenko, Peter Kuipers Munneke, Andrew Romero-Wolf, Dustin M. Schroeder, Martin J. Siegert. Reflections on the anomalous ANITA events: the Antarctic subsurface as a possible explanation. Annals of Glaciology, 2020; 1 DOI: 10.1017/aog.2020.19 Benjamin Boe, Shadia Habbal, Miloslav Druckmüller. Coronal Magnetic Field Topology from Total Solar Eclipse Observations. The Astrophysical Journal, 2020; 895 (2): 123 DOI: 10.3847/1538-4357/ab8ae6

Flourish.Mom Podcast
Brain, Behaviour & Neuroscience | Psych-100 | Chapter 17 | Flourish with Diane Planidin

Flourish.Mom Podcast

Play Episode Listen Later Jun 19, 2022 25:24


The human brain is responsible for all behaviors, thoughts, and experiences described in this textbook. This module provides an introductory overview of the brain, including some basic neuroanatomy, and brief descriptions of the neuroscience methods used to study it. Learning Objectives - Name and describe the basic function of the brain stem, cerebellum, and cerebral hemispheres. - Name and describe the basic function of the four cerebral lobes: occipital, temporal, parietal, and frontal cortex. - Describe a split-brain patient and at least two important aspects of brain function that these patients reveal. - Distinguish between gray and white matter of the cerebral hemispheres. - Name and describe the most common approaches to studying the human brain. - Distinguish among four neuroimaging methods: PET, fMRI, EEG, and DOI. - Describe the difference between spatial and temporal resolution with regard to brain function. Live an Inspired Life! #Psychology #QueensU #Brain Find out more about Flourish at the links below: ➡️ https://www.Flourish.Mom ➡️ Facebook https://www.Facebook.Com/Flourish.Mom ➡️ Twitter: https://www.Twitter.Com/FlourishMom ➡️ Instagram: https://www.Instagram.com/FlourishMom ➡️ Pinterest: https://www.Pinterest.ca/WowFlourishMom ➡️ Watch on YouTube: https://youtu.be/HP40bj2j7Ks   PSYC 100: Principles of Psychology F21 by PSYC100 is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, except where otherwise noted. Note:  I am a student and not a teacher.  This is my learning journey that I am sharing with you :)

CHEST Journal Podcasts
Perceptions of Life Support and Advance Care Planning During the COVID-19 Pandemic

CHEST Journal Podcasts

Play Episode Listen Later Jun 17, 2022 49:42


Moderator Viren Kaul, MD, FCCP, and journal CHEST® authors Vishal R. Patel, BS, and Gregory Wallingford, MD, MBA, discuss the article, "Perceptions of Life Support and Advance Care Planning During the COVID-19 Pandemic," which was published in the June issue. DOI: https://doi.org/10.1016/j.chest.2022.01.023

AJP-Heart and Circulatory Podcasts
Vascular Function, Mortality and COVID-19

AJP-Heart and Circulatory Podcasts

Play Episode Listen Later Jun 17, 2022 22:12


First, a thank you to frontline healthcare workers, clinical researchers, and one determined master's student Michelle Cristina-Oliveira of the Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo for their bravery and dedication to science and medicine! In this episode we bring you a conversation between Associate Editor Dr. Jason Carter (Montana State University), lead author Dr. Tiago Pecanha (Universidade de São Paulo, and Manchester Metropolitan University), and expert Dr. Paul Fadel (The University of Texas at Arlington). From June 2020 to May 2021 first author Michelle Cristina-Oliveira screened over 600 patients at the height of the COVID-19 pandemic in São Paulo, Brazil in order to enroll 211 COVID-19 patients within 72 hours of hospital admission. The authors sought to determine whether brachial artery flow-mediated dilation and carotid intima-media thickness measured upon hospital admission were associated with acute outcomes in hospitalized COVID-19 patients. Based on initial case reports, Cristina-Oliveira et al. felt that the endothelium could be an important target for SARS-CoV2. The authors hypothesized that measuring markers of endothelial function and atherosclerosis upon hospital admission could provide critically important information about potential risks of mortality, admission to ICU, and requirement for mechanical ventilation. Did the authors find that endothelial function and atherosclerosis were useful in predicting major clinical outcomes of COVID-19 patients? This study lends further insight into understanding the role of reduced flow mediated dilation in mediating the negative effects of COVID on cardiovascular health. Listen to find out why.   Michelle Cristina-Oliveira, Kamila Meireles, Saulo Gil, Fábio Cavalcante Assis, João Carlos Geber-Júnior, Samuel Katsuyuki Shinjo, Heraldo Possolo de Souza, Alfredo Nicodemos Cruz Santana, Paul A. Swinton, Luciano F. Drager, Bruno Gualano, Hamilton Roschel, and Tiago Peçanha Carotid intima-media thickness and flow-mediated dilation do not predict acute in-hospital outcomes in patients hospitalized with COVID-19 Am J Physiol Heart Circ Physiol, published April 22, 2022. DOI: 10.1152/ajpheart.00026.2022

Pediheart: Pediatric Cardiology Today
Pediheart Podcast #211: CMR Trends In Pediatric And Congenital Cardiology - An SCMR Report

Pediheart: Pediatric Cardiology Today

Play Episode Listen Later Jun 17, 2022 28:50


This week we speak with Associate Professor of Pediatrics at University of Washington Sujatha Buddhe of Seattle Children's Hospital about a recent survey study she conducted regarding CMR in the pediatric and congenital heart patient. How have volumes of cases changed over the past few years? Who is reading these studies? What is the advantage of a 1.5T vs. 3.0T scanner for congenital scans? What are the advantages and limitations of a survey study? Dr. Buddhe provides the answers this week. DOI: 10.1186/s12968-021-00830-4

House of Modern History
Trauma in und durch Forschung – mit Hannah Rudolph

House of Modern History

Play Episode Listen Later Jun 16, 2022 90:03


Schauspielerei war Hannah zu prekär, deshalb das Geschichtsstudium. Wir sprechen mit Hannah Rudolph, Doktorandin an der Universität Göttingen. Hannah forscht zum Thema Opfer von terroristischer Gewalt. Wir sprechen mit Hannah über viele Thema aber hauptsächlich geht es in dieser Folge um das Thema Trauma: Was ist Trauma? Wie sprechen wir von Traumata? Wie wird in der Geschichtswissenschaft über das Thema Trauma geforscht? Aber wir sprechen auch über den Umgang von Historiker:innen mit potentiell traumatisierenden Quellen und welche Strategien Hannah hat und der Umgang in der Lehre damit. Quellen 190220 – Ein Jahr nach Hanau: https://open.spotify.com/show/0Z2UJwgGfDnxrIhJpefINW 9/11 Tribute Center: https://911tributemuseum.org/ Brunner, José: Die Politik des Traumas. Gewalterfahrungen und psychisches Leid in den USA, in Deutschland und im Israel/Palästina-Konflikt. Berlin, 2014. Cole, Alyson: The Cult of True Victimhood: From the War on Welfare to the War on Terror. Stanford University Press, 2003. Därmann, Iris: Undienlichkeit. Gewaltgeschichte und politische Philosophie. Berlin, 2020. Foucault; Michel: Überwachen und Strafen. Die Geburt des Gefängnisses. Glynn, Ruth: The ‘turn to the victim' in Italian culture: victim-centred narratives of the anni di piombo, Modern Italy 18:4, November 2013, S. 373 – 390. DOI: https://doi.org/10.1080/13532944.2013.816473 Goltermann, Svenja: Opfer. Die Wahrnehmung von Krieg und Gewalt in der Moderne. Frankfurt am Main, 2017. Hájková, Ana & Contreras, Jazmine: Depression, Antisemitismus und Geschichtsschreibung: In Erinnerung an Evelien Gans, 2022: https://geschichtedergegenwart.ch/depression-antisemitismus-und-geschichtsschreibung-in-erinnerung-an-evelien-gans/ Knoch, Habbo & Möckel, Benjamin: Moral History. Überlegungen zu einer Geschichte des Moralischen im »langen« 20. Jahrhundert, in: Zeithistorische Forschungen/Studies in Contemporary History, Online-Ausgabe, 14 (2017): https://zeithistorische-forschungen.de/1-2017/5454 Hillbrenner, Anke: Gewalt als Sprache der Straße: Terrorismus als Form politischer Kommunikation im Russischen Reich vor 1917. Bonn, 2014. Jensen, Uffa: Zornpolitik. Suhrkamp, 2017. Podcast RAF in Hessen: https://hlz.hessen.de/themen/podcast/die-raf-in-hessen-50-jahre-mai-offensive-1972/ Podcast Terrorismus, Bundeszentrale für politische Bildung: https://www.bpb.de/mediathek/podcasts/terrorismus-strategie-des-schreckens/ Reddy, William M.: Against Constructionism: The Historical Ethnography of Emotions. Current Anthropology 38, 1997, S. 327-351. Robins, James: Can Historians be Traumatized by History? https://newrepublic.com/article/161127/can-historians-traumatized-history Rudolph Hannah & Terhoeven, Petra: Wem gebührt unser Mitleid? https://wem-gebuehrt-unser-mitleid.uni-goettingen.de/podcast-uni-goettingen/ Shnayien, Mary: Sichere Räume, reparative Kritik. Überlegungen zum Arbeiten mit verletzendem Material. In: Zeitschrift für Medienwissenschaft, Jg. 14 (2022), Nr. 1, S. 54–65. DOI: https://doi.org/10.25969/mediarep/18126 Tändler, Maik: Das therapeutische Jahrzehnt. Der Psychoboom in den siebziger Jahren. Göttingen, 2016. Petra Terhoeven (Ed.), Victimhood and Acknowledgement: The Other Side of Terrorism, Berlin/Boston 2018. Waldmann, Peter: Terrorismus und Bürgerkrieg. Der Staat in Bedrängnis. München, 2003.

Much Ado About Nerding
Slang Through The Years

Much Ado About Nerding

Play Episode Listen Later Jun 16, 2022 97:15


Join US! For a look at those fan fave colloquilaisms that keep the younger generation cool and the old timers scratching their heads. We look into some slang terms from decades past and today...  Much Ado About Nerding Content written, performed and edited by Joe Otero and Selena Otero. Theme created by Selena Otero. Executive Producers Joe Thanks for stopping by, if you like what you heard please LIKE, COMMENT, RATE and SUBSCRIBE to the Pod on whatever platform you are listening on. And Please SHARE with fellow Nerds and welcome them into Nerd Nation! Podcast Producers Our Patreons No One Trolls Like Gaston, Professor Em, Master of Muggle Studies, Motor City Timmy T, Machine Gun Paulie, The Phoenix Fam, StellarGem and Alice In Mother Land Patreon Patreon.com/muchadoaboutnerding Instagram Much_Ado_About_Nerding Email nerdnation2020@gmail.com Sounder Webpage muchadoaboutnerding.sounder.fm YouTube and Selena. Thanks for listening and until next time stay Rad and NERDY ON!!! Player 1's Episode Notes Cool Fuck Duh, Doi, no duh/doi AlL that and a bag of chips 411 DAP The next time you're really enjoying something, be sure to let everyone know you think it's DAP. "[It's] an acronym for Dead Ass Perfect and comes from the 50s jazz era when something — whether it is a riff or a trumpet solo or martini — is simply excellent," Brenda Knight, author of Women of the Beat Generation , tells Bustle. So useful, right? https://www.bustle.com/articles/201202-11-hilarious-old-fashioned-slang-words-we-should-bring-backv Don't have a cow Know Your Onions To "know your onions" is to know what's up or what's going on, according to Nico Lang on ThoughtCatalog.com. This one is out of the 20s — a decade where many a ridiculous phrase was uttered. Maybe it's time we bring some of them back? Twitterpated Marine Corps Ricky Tick-quick fast and I a a hurry Assholes and elbows- do it now Trackin?- understand? Dag'on it's how it's said that makes it military New Mexican The higherarchy of “A La” A la- excitement or exasperation much like the word fuck is so versatile A la A la vagers this is what kids say as to not get smacked A la maquina amazed disbelief To the machine A la verga Then the apex A la FUCKING verga, bro! Means to the dick It's slang for oh fuck/holy fuck We used to say “psycho” or “psychopathic” if something was all crazy “All…” adds emphasis to whatever you're saying “Uhmbers”… shame shame “Eeeeeeee” “Mimis” sleep I'm guessing derived from dormir

Psychologický podcast
32. Dětská Ψ: Co způsobuje syndrom zavrženého rodiče?

Psychologický podcast

Play Episode Listen Later Jun 16, 2022 23:21


Chceš více dílů Psychologického podcastu? Pojď na www.pickey.cz/psychologickypodcast Slyšeli jste už pojem "zavržený rodič"? Proč je důležité, abychom o něm věděli? A aby o něm věděli odborníci (psychologivé, učitelé, vychovatelé, prívníci a soudci)? Jak se něco takového může stát? Jaké jsou projevy a jaké následky pro dítě a jeho vztahem s rodiči to může zanechat? Nejen tomu se věnuje tato epizoda. Týká se tě téma osobně? Využij následující kontakt: Pro děti: Linka bezpečí 116 111, pomoc@linkabezpeci.cz Rodičovská linka: 606 021 021, pomoc@rodicovskalinka.cz psychologickypodcast@gmail.com IG: @evapsycholog Budu ráda, když mě podpoříte zakoupením Galaxie hněvu na www.citoprostor.cz/galaxie-hnevu/ Zdroje: The parental alienation syndrome: A Family therapy and collaborative systems approach to amelioration - Linda J. Gottlien The international handbook of parental a lienation syndrome: Conceptual, clinical and legal considerations - Richard A. Gardner von Boch-Galhau, W. (2018). Parental Alienation (Syndrome)-A serious form of psychological child abuse. In Ment Health Fam Med (Vol. 13). www.mc.vanderbilt.edu/pasg Miralles, P., Godoy, C., & Hidalgo, M. D. (2021). Long-term emotional consequences of parental alienation exposure in children of divorced parents: A systematic review. Current Psychology. https://doi.org/10.1007/s12144-021-02537-2 Baker, A. J. L., & Darnall, D. (2006). Behaviors and strategies employed in parental alienation a survey of parental experiences. Journal of Divorce and Remarriage, 45(1–2), 97–124. https://doi.org/10.1300/J087v45n01_06 Amy J. L. Baker & Maria Christina Verrocchio (2016) Exposure to ParentalAlienation and Subsequent Anxiety and Depression in Italian Adults, The American Journal ofFamily Therapy, 44:5, 255-271, DOI: 10.1080/01926187.2016.1230480 Music: www.free-stock-music.com

Oncotarget
Behind the Study: IGF-pathway Biomarkers and Lung Cancer

Oncotarget

Play Episode Listen Later Jun 14, 2022 4:37


Dr. Alexander Pohlman from Rush Medical College, Rush University Medical Center, Chicago, IL, describes a recent review published by Oncotarget that he co-authored entitled, “The role of IGF-pathway biomarkers in determining risks, screening, and prognosis in lung cancer.” DOI - https://doi.org/10.18632/oncotarget.28202 Correspondence to - Jeffrey A. Borgia - jeffrey_a_borgia@rush.edu Abstract Background: Detection rates of early-stage lung cancer are traditionally low, which contributes to inconsistent treatment responses and high rates of annual cancer deaths. Currently, low-dose computed tomography (LDCT) screening produces a high false discovery rate. This limitation has prompted research to identify biomarkers to more clearly define eligible patients for LDCT screening, differentiate indeterminate pulmonary nodules, and select individualized cancer therapy. Biomarkers within the Insulin-like Growth Factor (IGF) family have come to the forefront of this research. Main Body: Multiple biomarkers within the IGF family have been investigated, most notably IGF-I and IGF binding protein 3. However, newer studies seek to expand this search to other molecules within the IGF axis. Certain studies have demonstrated these biomarkers are useful when used in combination with lung cancer screening, but other findings were not as conclusive, possibly owing to measurement bias and non-standardized assay techniques. Research also has suggested IGF biomarkers may be beneficial in the prognostication and subsequent treatment via systemic therapy. Despite these advances, additional knowledge of complex regulatory mechanisms inherent to this system are necessary to more fully harness the potential clinical utility for diagnostic and therapeutic purposes. Conclusions: The IGF system likely plays a role in multiple phases of lung cancer; however, there is a surplus of conflicting data, especially prior to development of the disease and during early stages of detection. IGF biomarkers may be valuable in the screening, prognosis, and treatment of lung cancer, though their exact application requires further study. Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28202 Keywords - IGF, lung cancer, biomarkers, screening, prognostication About Oncotarget Oncotarget is a peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/OncotargetYouTube LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Oncotarget is published by Impact Journals, LLC: https://www.ImpactJournals.com Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

Hotkeys Podcast
Hot+keys #144: Chunk of Monk

Hotkeys Podcast

Play Episode Listen Later Jun 13, 2022 72:02


Listen to us talk about Obi-Wan, The Boys, Barry, Peaky Blinders, Shanghai Knights, Stranger Things, Psych, Mona Lisa's dessert, Banksy, and a DOI quiz. Starring David Parker, Landon Browning, Mick Parker, and Jordan Elton. Recorded June 4th, 2022.

Lagrange Point
Episode 487 - Feeding the planet without damaging it

Lagrange Point

Play Episode Listen Later Jun 13, 2022 15:43


​As our climate changes, feeding the planet without making things worse is a big challenge. How do plants work together to survive extreme weather events? When there is a large drought or extreme weather event what works better, single species or mixed? Plant diversity can help plants weather the storm of climate change and come out stronger. How do cover crops help 'fix' nitrogen in the soil and reduce negative climate impacts. Excess fertiliser is not only expensive for farmers but damaging to the local and global environment. How can cover crops help soil recover and reduce negative climate change impacts of mono cropping.  Yuxin Chen, Anja Vogel, Cameron Wagg, Tianyang Xu, Maitane Iturrate-Garcia, Michael Scherer-Lorenzen, Alexandra Weigelt, Nico Eisenhauer, Bernhard Schmid. Drought-exposure history increases complementarity between plant species in response to a subsequent drought. Nature Communications, 2022; 13 (1) DOI: 10.1038/s41467-022-30954-9 Nakian Kim, Chance W. Riggins, María C. Zabaloy, Marco Allegrini, Sandra L. Rodriguez-Zas, María B. Villamil. High-Resolution Indicators of Soil Microbial Responses to N Fertilization and Cover Cropping in Corn Monocultures. Agronomy, 2022; 12 (4): 954 DOI: 10.3390/agronomy12040954 Nakian Kim, Chance Riggins, María C. Zabaloy, Sandra Rodriguez-Zas and María B. Villamil. Limited impacts of cover cropping on soil N-cycling microbial communities of long-term corn monocultures. Frontiers in Microbiology, 2022 DOI: 10.3389/fmicb.2022.926592

CUBIST
CUBIST S3E10: Self-Reported TBI Symptoms During Deployment

CUBIST

Play Episode Listen Later Jun 13, 2022


In this episode of CUBIST, Don, and Amanda discuss the article, “Self-Reported Concussion Symptomology during Deployment: Differences as a Function of Injury Mechanism and Low-Level Blast Exposure” published in the Journal of Neurotrauma in May of 2020. Article Citation: Belding, J. N., Fitzmaurice, S., Englert, R. M., Koenig, H. G., Thomsen, C. J., & Olaghere da Silva, L. U. (2020). Self-Reported Concussion Symptomology during Deployment: Differences as a Function of Injury Mechanism and Low-Level Blast Exposure. Journal of Neurotrauma. DOI: 10.1089/neu.2020.6997. Article LINK: pubmed.ncbi.nlm.nih.gov/32368945 CUBIST is a podcast for health care providers produced by the Traumatic Brain Injury Center of Excellence. We discuss the latest research on traumatic brain injury (TBI) most relevant to patient care. For more about TBI, including clinical tools, go to health.mil/TBICoE or email us at dha.TBICoEinfo@mail.mil.

Herpetological Highlights
113 Bearded Dragons Dodgy Dinners

Herpetological Highlights

Play Episode Listen Later Jun 9, 2022 26:15


Bearded dragons love to eat bugs, but pesticide use means they aren't always as good as they look. Become a Patreon: https://www.patreon.com/herphighlights Full reference list available here: http://www.herphighlights.podbean.com Main Paper References: Contador-Kelsall I, Maute K, Story P, Hose GC, French K. 2022. Sublethal pesticide exposure influences behaviour, but not condition in a widespread Australian lizard. Conservation Physiology 10:coac024. DOI: 10.1093/conphys/coac024. Other Mentioned Papers/Studies: Entiauspe‐Neto, O. M., Reichle, S., & Dos Rios, A. (2022). A case of playful interaction between Bolivian River Dolphins with a Beni Anaconda. Ecology, e3724. Music: Intro/outro – Treehouse by Ed Nelson Species Bi-week theme – Mike Mooney

Oncotarget
Press Release: Group of Genes That Cause Endocrine Resistance in Breast Cancer Identified ...

Oncotarget

Play Episode Listen Later Jun 8, 2022 4:02


BUFFALO, NY- June 8, 2022 – A research paper was recently published in Oncotarget, entitled, “A novel group of genes that cause endocrine resistance in breast cancer identified by dynamic gene expression analysis.” Breast cancer (BC) is the most common type of cancer diagnosed in women. Among female cancer deaths, BC is the second leading cause of death worldwide. For estrogen receptor-positive (ER-positive) breast cancers, endocrine therapy is an effective therapeutic approach. However, in many cases, ER-positive tumors become unresponsive to endocrine therapy, and tumor regrowth can occur after treatment. While some genetic mutations contribute to resistance in some patients, the underlying causes of resistance to endocrine therapy are mostly undetermined. “Endocrine therapies have been successful at improving cancer outcomes; however, the development of endocrine resistance, or resistance to inhibition of ER actions, remains a roadblock in breast cancer treatment.” In the current study, researchers from UTHealth Houston, University of Chicago, University of Texas MD Anderson Cancer Center, and the University of Houston explored the dynamic behavior of the entire gene population to identify novel genes that play fundamental roles in the development and progression of endocrine-resistant breast cancer. “In this study, we utilized a recently developed statistical approach to investigate the dynamic behavior of gene expression during the development of endocrine resistance and identified a novel group of genes whose time course expression significantly change during cell modelling of endocrine resistant BC development.” To better understand the process of acquiring endocrine resistance and its underlying gene expression patterns, the researchers applied their recently developed statistical pipeline to datasets from a public functional genomics repository. They found dynamically regulated genes active in the process of endocrine resistance development and progression. Their dynamic gene expression analysis identified 34 novel genes that significantly changed during cell modeling of endocrine-resistant breast cancer development. Expression of a subset of these genes was also differentially expressed in microarray analysis of endocrine-resistant and endocrine-sensitive tumor samples. Surprisingly, a subset of those genes was also differentially expressed in triple-negative breast cancer (TNBC) as compared with ER-positive BC. “The findings suggest shared genetic mechanisms may underlie the development of endocrine resistant BC and TNBC.” DOI: https://doi.org/10.18632/oncotarget.28225 Correspondence to: Michihisa Umetani – mumetani@uh.edu, and Vahed Maroufy – Vahed.Maroufy@uth.tmc.edu Special Collection on Breast Cancer: https://www.oncotarget.com/collections/breast-cancer/ Keywords: breast cancer, triple negative breast cancer, gene expression profiling, endocrine resistance, gene clustering About Oncotarget: Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, visit Oncotarget.com and connect with us on social media: Twitter – https://twitter.com/Oncotarget Facebook – https://www.facebook.com/Oncotarget YouTube – www.youtube.com/c/OncotargetYouTube Instagram – https://www.instagram.com/oncotargetjrnl/ LinkedIn – https://www.linkedin.com/company/oncotarget/ Pinterest – https://www.pinterest.com/oncotarget/ LabTube – https://www.labtube.tv/channel/MTY5OA SoundCloud – https://soundcloud.com/oncotarget For media inquiries, please contact: media@impactjournals.com.

Evidence Based Birth®
EBB 227 – Amplifying the Need for Intersectional Birth Support for QTBIPOC Birthing People with Xian Brooks of the Dandy Doula

Evidence Based Birth®

Play Episode Listen Later Jun 8, 2022 52:56


On today's podcast, we're going to talk with the founder of Dandy Doula, Xian Brooks, MPH, about the importance of intersectional birth work and amplifying the need for intersectional birth support for queer, trans, and BIPOC birthing bodies. Xian Brooks (he/him) is a public health professional from Louisville, Kentucky, where he is a community-based birth doula and a Master of Science in Nursing student. Xian completed his Bachelor's of Science in Public Health Education at North Carolina Central University and his Master's of Public Health in Community and Behavioral Health at the University of Colorado. Over time, Xian has accumulated a lot of experience in queer, trans, non-binary, and gender non-conforming reproductive health education. Xian's training has equipped him to understand the root causes of perinatal death rates among Black individuals, especially how race, gender, sexual orientation, and class are not mutually exclusive when it comes to health disparities. Xian's lived experience recognizes that health disparities are more than just numbers on a page. Xian is currently working towards becoming a nurse-midwife because representation in healthcare is extremely important to Xian. He firmly believes it is necessary to overcome negative health outcomes and revolutionize healthcare. We talk about what inspired Xian to dive into the work of community and behavioral health as well as his journey as a nurse-midwife. We also discuss what intersectional birth work looks like and the importance to amplify the need to create safe perinatal spaces for queer, trans, and BIPOC birthing bodies.  Content warning: We mention transphobia, misgendering, deadnaming, racism, police violence, and birth trauma. RESOURCES: Learn more about Xian Brooks and The Dandy Doula here. Follow The Dandy Doula on Facebook and Instagram.  Hoyert DL. Maternal mortality rates in the United States, 2019. NCHS Health E-Stats. 2021. DOI: https://doi.org/10.15620/cdc:103855. Hunter, L., McMahon, E., Graves, B., Wooten, A., Kriebs, J., Pickett, E., Tanner, T., Garcia, R., Apatov, N., Burkman, R., Hodges, K., & Bright, C. (2019). (rep.). 2019 Demographic Report (p. 1). Linthicum, Maryland: American Midwifery Certification Board. Loewenberg Weisband, Y., Klebanoff, M., Gallo, M. F., Shoben, A., & Norris, A. H. (2018). Birth outcomes of women using a midwife versus women using a physician for prenatal care. Journal of Midwifery & Women's Health, 63(4), 399–409. https://doi.org/10.1111/jmwh.12750 Taffe MA, Gilpin NW. Racial inequity in grant funding from the US National Institutes of Health. Elife. 2021;10:e65697. Published 2021 Jan 18. doi:10.7554/eLife.65697.  Tikkanen, R., Gunja, M. Z., FitzGerald, M., & Zephyrin, L. (2020). Maternal mortality and maternity care in the United States compared to 10 other developed countries. Issue briefs, Commonwealth Fund.  For more information and news about Evidence Based Birth®, visit www.ebbirth.com. Find us on Facebook (https://www.facebook.com/EvidenceBasedBirth/ ), Instagram (https://www.instagram.com/ebbirth/), and Pinterest (https://www.pinterest.com/ebbirth/). Ready to get involved? Check out our Professional membership (including scholarship options) (https://evidencebasedbirth.com/become-pro-member/). Find an EBB Instructor here (https://evidencebasedbirth.com/find-an-instructor-parents/), and click here (https://evidencebasedbirth.com/childbirth-class/) to learn more about the Evidence Based Birth® Childbirth Class.

Lagrange Point
Episode 486 - Bypassing the brains defences for treatment

Lagrange Point

Play Episode Listen Later Jun 6, 2022 21:29


The brain is incredibly important and needs to be protected by your body but this also makes it hard to treat. Brain tumours can be stubborn to root out because many treatments are blocked by the blood brain barrier. The blood brain barrier blocks many cancer treatments, but with the right disguise and nano coating cancer treatments can sneak past. Brain tumours can block the immune system from functioning, but sneaking through the right treatment can help the immune system fight back. Traumatic brain injury and subsequent inflammation can lead to significant damage, and normal anti-inflammatory methods are blocked by the blood brain barrier. If you can't sneak anti-inflammatories through the blood brain barrier, why not just boost their production locally? T Cells can fight back against inflammation after a traumatic brain injury if there's enough food for them to thrive on.  Yshii, L., Pasciuto, E., Bielefeld, P. et al. Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation. Nat Immunol, 2022 DOI: 10.1038/s41590-022-01208-z Mahmoud S. Alghamri, Kaushik Banerjee, Anzar A. Mujeeb, Ava Mauser, Ayman Taher, Rohit Thalla, Brandon L. McClellan, Maria L. Varela, Svetlana M. Stamatovic, Gabriela Martinez-Revollar, Anuska V. Andjelkovic, Jason V. Gregory, Padma Kadiyala, Alexandra Calinescu, Jennifer A. Jiménez, April A. Apfelbaum, Elizabeth R. Lawlor, Stephen Carney, Andrea Comba, Syed Mohd Faisal, Marcus Barissi, Marta B. Edwards, Henry Appelman, Yilun Sun, Jingyao Gan, Rose Ackermann, Anna Schwendeman, Marianela Candolfi, Michael R. Olin, Joerg Lahann, Pedro R. Lowenstein, Maria G. Castro. Systemic Delivery of an Adjuvant CXCR4–CXCL12 Signaling Inhibitor Encapsulated in Synthetic Protein Nanoparticles for Glioma Immunotherapy. ACS Nano, 2022; DOI: 10.1021/acsnano.1c07492

AJP-Heart and Circulatory Podcasts
Prenatal Dexamethasone Alters Female Cardiovascular Function

AJP-Heart and Circulatory Podcasts

Play Episode Listen Later Jun 6, 2022 21:29


How does in utero glucocorticoid administration impact autonomic control of the heart in adult offspring in a sex-dependent manner? In this episode, Associate Editor Dr. Crystal Ripplinger (University of California – Davis) interviews authors Dr. Taben Hale and Lakshmi Madhavpeddi (University of Arizona) along with expert Dr. Glen Pyle (University of Guelph) about the new work by Madhavpeddi et al. The authors administered dexamethasone to pregnant rats using a dose and timing that closely mimicked clinical application of dexamethasone administration to pregnant women at risk for preterm delivery to prevent respiratory distress in newborns. At baseline, the authors did not observe any differences between the prenatally-exposed offspring and controls. In response to an experimental stressor, however, the authors found that prenatal exposure to dexamethasone resulted in exaggerated blood pressure and heart rate only in adult female rats. Prenatally-exposed adult male rats did not exhibit any stress response changes in cardiovascular function. In addition, only the dexamethasone-exposed adult female offspring showed a reduction in the high frequency component of heart rate variability, indicating withdrawal of parasympathetic activity. What role does angiotensin II play in the altered autonomic response induced by prenatal dexamethasone exposure? Can we derive important potential clinical applications of this work related to the long-term impact on offspring from treatments administered during their mothers' pregnancies? Listen now to find out.   L. Madhavpeddi, B. Hammond, D. L. Carbone, P. Kang, R. J Handa, T. M. Hale Impact of angiotensin II receptor antagonism on the sex-selective dysregulation of cardiovascular function induced by in utero dexamethasone exposure Am J Physiol Heart Circ Physiol, published March 17, 2022. DOI: 10.1152/ajpheart.00587.2021

CHEST Journal Podcasts
Setting and Titrating Positive End Expiratory Pressure

CHEST Journal Podcasts

Play Episode Listen Later Jun 6, 2022 34:48


CHEST June 2022, Volume 161, Issue 6 Scott J Millington, MD, joins CHEST Podcast Moderator, Dominique Pepper, MD, to discuss selecting and titrating positive end-expiratory pressure. DOI: https://doi.org/10.1016/j.chest.2022.01.052  

CHEST Journal Podcasts
Should therapeutic heparin be administered to acutely-ill hospitalized patients with COVID-19

CHEST Journal Podcasts

Play Episode Listen Later Jun 6, 2022 16:20


CHEST June 2022, Volume 161, Issue 6 David Jimenez, MD, PhD, and Tobias Tritschler, MD, MSc, join CHEST Podcast Moderator, Gretchen Winter, MD, to discuss whether therapeutic heparin should be administered to acutely-ill hospitalized patients with COVID-19. DOI: https://doi.org/10.1016/j.chest.2022.01.036 DOI: https://doi.org/10.1016/j.chest.2022.01.037  DOI: https://doi.org/10.1016/j.chest.2022.01.038  DOI: https://doi.org/10.1016/j.chest.2022.01.039 

Leadership Today Podcast
Episode 140 - Variety is the Spice of Development

Leadership Today Podcast

Play Episode Listen Later Jun 3, 2022 4:00


SUMMARY Variety may be the spice of life, but it also helps with personal development.   TRANSCRIPT Welcome to episode 140 of the Leadership Today podcast where each week we bring research to life in your leadership. This week we discuss how variety can help with learning and development. You may have heard the expression that variety is the spice of life, but variety also turns out to be important for development and learning. Research shows us that learning in a broader and more variable setting ultimately helps us to do three things: It helps us to better identify which elements are relevant It helps us to make broader generalisations It forces us to reconstruct memories - getting us out of the ruts that might otherwise trap us Let's take an example from the research. If an infant is learning what a dog is as a category, it's quick and easy to just show them one type of dog. Show them that exact dog, and they will tell you that it is a dog. It takes longer to learn what a dog is if we expose that same infant to multiple types of dogs, however they're then much better at generalising that learning to a new type of dog. If I've only ever seen one type of dog, I may not correctly identify a new type of dog as a dog. If instead I learned what a dog is by seeing lots of different examples, I'm much better able to correctly identify a new type of dog. The same principle applies for adults learning a new sport. One option if I'm learning tennis would be to practice one shot over and over again. Another way could involve learning and practicing lots of different shots. The second way takes a lot longer to get us to the point where we can hit the ball over the net, but it is going to be much better in the unpredictability of a tennis match than the first approach to learning. So variety and variability in learning is harder, but it leads to better generalisation.  The researcher Raviv highlights a great example of this relating to face recognition.He shares that “face recognition is affected by whether people grew up in a small community (fewer than 1000 people) or in larger community (over 30,000 people). Exposure to fewer faces during childhood is associated with diminished face memory." So even in social skills like face recognition, we're better off learning with variability and variety. Other research highlights that even incidental exposure to something new primes us to learn more about it. There's something about allowing ourselves to be exposed to new experiences and things that sets us up for learning.  So how much variety is there in your job? How often in the average week are you trying things for the first time? We all know that learning is hard - it takes effort. But if we want to maximise our learning and ability, it's important to remember that variety is the spice of development.   REFERENCES Limor Raviv, Gary Lupyan, Shawn C. Green. How variability shapes learning and generalization. Trends in Cognitive Sciences, 2022; DOI: 10.1016/j.tics.2022.03.007 Layla Unger, Vladimir M. Sloutsky. Ready to Learn: Incidental Exposure Fosters Category Learning. Psychological Science, 2022; 095679762110614 DOI: 10.1177/09567976211061470

The Wholesome Show
What Do We Do With The Immortal Quadrillionaires?

The Wholesome Show

Play Episode Listen Later Jun 3, 2022 66:02


Guess what listener - it's possible that people alive today might live a very long life... like 1200 years maybe. That sounds fun, but maybe it might lead to dystopia? Will agonises with Rod about what we should do about longevity treatments! The Wholesome Show is Dr Rod Lamberts and Dr Will Grant, proudly brought to you by The Australian National Centre for the Public Awareness of Science! Sources: Aeon: What are the ethical consequences of immortality technology? https://aeon.co/ideas/what-are-the-ethical-consequences-of-immortality-technology BBC: A frozen graveyard: The sad tales of Antarctica's deaths: https://www.bbc.com/future/article/20180913-a-frozen-graveyard-the-sad-tales-of-antarcticas-deaths EMBO Rep. Jayne Lucke and Wayne Hall: Who wants to live forever: 2005 Feb; 6(2): 98–102. doi: 10.1038/sj.embor.7400339 Bernard Williams: The Makropulos case: reflections on the tedium of immortality: https://web.archive.org/web/20160528020748/http://stoa.org.uk/topics/death/the-makropulos-case-reflections-on-the-tedium-of-immortality-bernard-williams.pdf Forbes: What Kills Billionaires: https://www.forbes.com/2005/04/05/cx_vg_0405feat.html John Hardwig: Is there a duty to die? The Hastings Center Report , Mar. - Apr., 1997, Vol. 27, No. 2 (Mar. - Apr., 1997), pp. 34-42 https://www.jstor.org/stable/3527626 JAMA Health Forum. Eric D Finegood et al. 2021;2(7):e211652. doi:10.1001/jamahealthforum.2021.1652 John Harris: The Harold Hatch International Lecture on Longevity and Population Aging Intimations of Immortality The Ethics and Justice of Life-Extending Therapies: https://www.ilc-alliance.org/wp-content/uploads/publication-pdfs/IntimationsImmortality.pdf Journal of Aging Studies: Public attitudes towards human life extension by intervening in ageing: Brad Partridge Jayne Lucke Helen Bartlett Wayne Hall https://www.sciencedirect.com/science/article/pii/S0890406510000757?casa_token=ELUiWi4dNksAAAAA:cziJHAtan_8s5o-az6WYOS8Kqwrre9g4YJ3jw1vhoUg7M1eWHHimfqRlbq3sKdzzbschLWviN6vE Live Science: The Ethical Dilemmas of Immortality https://www.livescience.com/10465-ethical-dilemmas-immortality.html Long Bets: Peter Schwartz and Melody Haller: At least one human alive in the year 2000 will still be alive in 2150.https://longbets.org/11/ NBCNews: Mainstream docs join anti-aging bandwagon: https://www.nbcnews.com/id/wbna23358964 REJUVENATION RESEARCH: Brad Partridge, Jayne Lucke, Helen Bartlett, and Wayne Hall: Ethical, Social, and Personal Implications of Extended Human Lifespan Identified by Members of the Public Volume 12, Number 5, 2009 a Mary Ann Liebert, Inc.
DOI: 10.1089=rej.2009.0907 Scientific American: Aging Is Reversible—at Least in Human Cells and Live Mice: https://www.scientificamerican.com/article/aging-is-reversible-at-least-in-human-cells-and-live-mice/ Wikipedia: Lawrence Oates: https://en.wikipedia.org/wiki/Lawrence_Oates Wikipedia: Richard Lamm: https://en.wikipedia.org/wiki/Richard_Lamm

ECCPodcast: Emergencias y Cuidado Crítico
103: Compendio de Guías sobre Manejo Prehospitalario de la Vía Aérea - Parte 1 Educación

ECCPodcast: Emergencias y Cuidado Crítico

Play Episode Listen Later Jun 1, 2022 18:41


La National Association of EMS Physicians (NAEMSP) publicó un compendio de posiciones oficiales sobre el manejo prehospitalario de la vía aérea. Esta es la primera vez que se publica un documento que sirva como referencia para la creación de protocolos. Existen muchos estudios sobre el manejo prehospitalario de la vía aérea. Este documento refleja las mejores prácticas a esta fecha, basados en la totalidad de los estudios. Destreza definitoria de la resucitación El manejo de la vía aérea es una de las destrezas que definen nuestra práctica de resucitar un paciente que no protege su vía aérea o que no tiene una respiración adecuada, indistintamente de su causa (paro cardiaco, de trauma, de sepsis, de un accidente cerebrovascular, etc.) A pesar de lo importante que es, las estadísticas presentan una imagen poco alentadora sobre la consistencia y eficacia de los sistemas de atención prehospitalaria. En otro momento discutiremos los beneficios versus los riesgos del manejo básico versus el manejo avanzado. Este artículo del compendio de manejo prehospitalario de la vía aérea se concentra en cómo enseñamos esta importante destreza. ¿Cargar y llevar o quedarse y jugar en el manejo prehospitalario de la vía aérea? Fuera del hospital existen dos tipos de pacientes: los que necesitan atención inmediata y los que necesitan transporte inmediato. A veces es fácil reconocer cada uno, pero a veces la situación puede ser difícil. Hay pacientes que necesitan ser intubados inmediatamente. Por ejemplo, hay pacientes que tienen traumas maxilofaciales tan severos que ya no pueden ventilar. Posiblemente inclusive pueda ser que necesiten una vía aérea quirúrgica. Por otro lado, hay pacientes que todavía están respirando espontáneamente pero están en fallo respiratorio. Está bien el pedir ayuda. Con pocas variaciones en el mundo, usualmente una ambulancia es operada por dos proveedores. Eso no significa que todas las condiciones pueden ser atendidas por dos personas. Inclusive en el hospital hay emergencias que requieren la presencia de al menos otro médico, y/o otros profesionales de la salud (enfermería, terapia respiratoria, etc.) Hay veces que la ayuda tiene que llegar al paciente y hay veces que el paciente llega a la ayuda. Hay limitaciones y hay circunstancias extremas... en ocasiones. Practica el escenario ideal. No es raro ver el instructor de manejo prehospitalario de la vía aérea simulando un escenario catastrófico donde un paciente está en un espacio confinado, con poca luz, poco espacio, difícil de remover del lugar, en una posición incómoda y bajo la lluvia. Si aprendemos de inicio a improvisar, empezamos a degradar el estándar de calidad. Luego comenzamos a improvisar la improvisación, y se sigue degradando aún más el estándar hasta que todo se reduce a simplemente un laringoscopio, un tubo endotraqueal y fuerza bruta. Debemos comenzar a pensar en el escenario ideal. El escenario ideal es la forma correcta de hacer el procedimiento bajo las circunstancias ideales. Por ejemplo, una intubación endotraqueal normal, común y corriente puede tomar 15-20 minutos desde que comienza la intubación hasta que se asegura el tubo. Hay demasiadas cosas que hacer para evitar que el paciente se deteriore por culpa de la intubación. Las recomendaciones buscan dos cosas: la seguridad del paciente y la mayor posibilidad de éxito. Si usted empieza a desviarse del "escenario ideal", comienza a aumentar la posibilidad de que algo malo le suceda al paciente. Cuando el escenario ideal no es posible, debemos pensar que "debemos hacerlo lo más ideal posible", y eso a veces puede tomar tiempo... y está bien que tome tiempo porque esa es la forma correcta de hacerlo cuando el paciente así lo necesita. "Yo trabajo en el hospital, esto no me aplica a mi." El paciente intrahospitalario tiene el beneficio teórico de que puede ser atendido por múltiples expertos. Algunos pacientes son intubados en sala de operaciones, bajo condiciones ideales, e inclusive utilizando recursos que se encuentran comúnmente en la calle (por ejemplo, fibra óptica). Aunque esto es cierto, ¡no siempre es así! Todos sabemos que el manejo de un paciente a las 10:00 am no es el mismo que a las 10:00 pm en muchos sitios. En muchos hospitales, hay menos recursos disponibles fuera de horas laborables. Esto tiene implicaciones serias ya que la definición de una "vía aérea fallida" es usualmente tres intentos por el operador más experimentado disponible. Lamentablemente a veces el operador disponible no necesariamente sería el mejor si hubiesen otros recursos disponibles. Los hospitales pequeños, que tienen pocos recursos, En el extremo opuesto del nivel de preparación, existen muchos hospitales (usualmente centros académicos) que tienen la misma capacidad de respuesta a las 2:00 am que a las 2:00 pm. Debemos prepararnos siempre para lo que va a ocurrir cuando un paciente necesita una vía aérea un sábado a las 2:00 am. Si pensamos en el peor escenario, lo demás es más fácil. Existen hospitales que, en determinado momento, tienen pocos recursos para atender lo que ciertamente es un paciente crítico. Entonces, quizás muchos proveedores de atención intrahospitalaria también pueden beneficiarse de repasar este documento. La prioridad es el paciente, no el procedimiento El objetivo del manejo prehospitalario de la vía aérea no es realizar un procedimiento, sino el resultado final del manejo del paciente. En la Sala de Operaciones comúnmente se intuba al paciente ante la necesidad de realizar un procedimiento. Fuera de la Sala de Operaciones se intuba el paciente comúnmente porque no puede proteger su vía aérea o no puede respirar adecuadamente. La frase "la intubación endotraqueal es el estándar de oro en el manejo de la vía aérea" ha hecho que muchos educadores y proveedores se enfoquen en el procedimiento como el objetivo. La intubación endotraqueal puede tener complicaciones adversas. Por ejemplo, el manejo de la inestabilidad hemodinámica y desaturación asociada a la intubación endotraqueal antes, durante y después del procedimiento es tan importante como la laringoscopía misma. El artículo nos invita a pensar en las siguientes preguntas: ¿Cuál destreza de la vía aérea le daría a este paciente la mejor oportunidad de sobrevivencia? Práctica deliberada en el manejo prehospitalario de la vía aérea La NAEMSP recomienda que las prácticas de manejo de la vía aérea estén basadas en práctica deliberada. ¿Qué es práctica deliberada? El esfuerzo continuo por ser mejor que ayer. ¿Cuál es el nivel de competencia deseado? Según el artículo, la toma de decisión de qué situaciones requieren manejo de la vía aérea es un diferenciador clave entre una competencia minima versus un dominio de la competencia. Los autores detallan que, aunque no existe un camino específico definitivo para lograr el dominio, el desarrollo de niveles más avanzados de competencia en el manejo completo de la vía aérea "requiere un esfuerzo consciente no solamente de las destrezas, sino de los modelos mentales incrementalmente más sofisticados que incorporan las complejidades de la fisiopatología, dinámicas de equipos y la evidencia, para permitir tomas de decisiones de orden superior. Idealmente la educación inicial debe lograr más que el desarrollo de las competencias mínimas." Competencia mínima versus dominio de la competencia Desde el punto de vista de educación, el problema no es identificar los criterios usar técnicas avanzadas. El verdadero reto es validar que la persona es competente. Cuando hablamos del nivel de competencia, no nos referimos al nivel de la destreza en términos de soporte vital básico o avanzado. Se refiere al grado de proficiencia a la hora de ejecutar la destreza. Se trata de practicar no solamente hasta que se logra hacer bien, sino hasta que se es consistentemente efectivo en diversos tipos de escenarios de forma segura para el paciente. Nuevamente, cuál es el nivel de destreza necesario? Que pueda hacerlo efectivamente y seguramente. El artículo señala que el uso de simuladores de la vía aérea y maniquís de baja fidelidad solamente permiten lograr un dominio de las competencias de soporte vital básico solamente. Las destrezas de soporte vital avanzado tienen otros elementos que requieren que el alumno reciba retroalimentación no solamente en un entorno de alta fidelidad, sino también de laboratorios con cadáveres y pacientes reales. Según el artículo, la realidad es que la mayoría de los sistemas que proveen educación van a tener acceso a poder lograr un dominio de la competencia de destrezas básicas. Sin acceso consistente a esas otras oportunidades más complejas antes mencionadas, es muy difícil esperar que un sistema pueda probar que ha logrado la competencia necesaria (dominio de la competencia) para realizar intervenciones que sean potencialmente peligrosas para el paciente. Destrezas básicas son destrezas fundamentales El objetivo es que el paciente tenga una vía aérea patente y esté ventilando. Cómo usted lo logra dependerá de las circunstancias de los proveedores, el lugar, y el paciente. Entonces, es importante enfocarse en aquellas destrezas que sí podemos lograr un nivel de dominio: las destrezas básicas. Toma de decisiones en el manejo prehospitalario de la vía aérea El pensar cómo es que tomamos las decisiones que tomamos. El artículo habla de la importancia de la "metacognición", o el "pensar sobre lo que pensamos". El por qué se tomó la decisión que se tomó quizás es más importante que resumir si una decisión fue correcta o no. El analizar el por qué permite entender mejor cuándo tomar la misma decisión, o cuándo no. Credencialización La credencialización es el proceso del patrono de determinar que una persona está lista para realizar un procedimiento específico. La credencialización es un proceso independiente del licenciamiento. Una persona puede tener una licencia en su jurisdicción de trabajo, pero no estar credencializado en un lugar de empleo. El director médico es la persona responsable dentro del servicio de emergencias médicas de credencializar al personal. La credencialización no es simplemente una charla, sino la validación (o revalidación de las destrezas). El proceso de credencialización no es un solo evento al principio, sino un proceso continuo. En adición, debe incluir todos los aspectos psicomotores, cognitivos y afectivos que se han descrito anteriormente. En otras palabras, la credencialización no puede ser solamente una charla y no puede ser solamente realizar una (o varias) intubaciones en un maniquí. Es importante señalar que la credencialización no tiene que ser solamente para destrezas de soporte vital avanzado. Si la vida del paciente depende de que el proveedor pueda tener un dominio absoluto de las destrezas cognitivas, afectivas y psicomotoras del manejo básico de la vía aérea, es importante que la simulación y credencialización esté dirigida a ese nivel básico también. Evolución de los adiestramientos Los adiestramientos de manejo (¿avanzado?) de la vía aérea tienen que evolucionar también. El objetivo del adiestramiento inicial debe ser lograr una competencia mínima. Sin embargo, el objetivo final no puede ser quedarse ahí solamente. El objetivo tiene que ser lograr el dominio de la competencia (al nivel que se quiera llegar) para entonces lograr la credencialización. Los adiestramientos tienen que evolucionar. Yo diría que muchos de los adiestramientos que tomamos están basados en la mejor evidencia disponible y así lo reflejan. Sin embargo, somos nosotros los instructores los que tenemos que actualizar los libretos que cada uno tenemos cuando hablamos de estos temas. No es raro todavía ver clases de Soporte Vital Cardiovascular Avanzado (ACLS) enfatizando la intubación endotraqueal cuando desde hace mucho estamos hablando de que esto no necesariamente debe ser el caso del manejo de la vía aérea en el paro cardiaco. Conclusión El manejo de la vía aérea es una de las destrezas fundamentales y definitorias de la resucitación de un paciente. Para lograr ser seguros y efectivos en estas destrezas, tenemos que incorporar muchos otros elementos en el proceso continuo del desarrollo de los conocimientos y destrezas. Referencias Maia Dorsett, Ashish R. Panchal, Christopher Stephens, Andra Farcas, William Leggio, Christopher Galton, Rickquel Tripp & Tom Grawey (2022) Prehospital Airway Management Training and Education: An NAEMSP Position Statement and Resource Document, Prehospital Emergency Care, 26:sup1, 3-13, DOI: 10.1080/10903127.2021.1977877

Herpetological Highlights
112 Intoxicated Crocs

Herpetological Highlights

Play Episode Listen Later Jun 1, 2022 31:39


Freshwater crocs are classic predators of the water's edge - but when prey changes, can they keep up? Become a Patreon: https://www.patreon.com/herphighlights Full reference list available here: http://www.herphighlights.podbean.com Main Paper References: Aiyer A, Shine R, Somaweera R, Bell T, Ward-Fear G. 2022. Shifts in the foraging tactics of crocodiles following invasion by toxic prey. Scientific Reports 12:1267. DOI: 10.1038/s41598-021-03629-6. Species of the Bi-Week: Marques MP, Ceríaco LMP, Stanley EL, Bandeira SA, Agarwal I, Bauer AM. 2019. A new species of Girdled Lizard (Squamata: Cordylidae) from the Serra da Neve Inselberg, Namibe Province, southwestern Angola. Zootaxa 4668:503–524. DOI: 10.11646/zootaxa.4668.4.4. Other Links/Mentions: Turtles making noise? - https://www.animalpicturesarchive.com/do-green-sea-turtles-make-noise/ Music: Intro/outro – Treehouse by Ed Nelson Species Bi-week theme – Mike Mooney

Lagrange Point
Episode 485 - Plants race against rising sea levels

Lagrange Point

Play Episode Listen Later May 30, 2022 19:31


How can plants adapt to a changing climate and strange volcanic soils. By tracking the divergent evolution of Thale Cress, scientists can track the genetic changes needed to thrive in weird soil. Volcanic soil can have benefits along with risks, but how can plants adapt quickly to odd soil types? How did plants learn to thrive on a volcanic island, Pico de Fogo. What can a long running study tell us about plants adapting to a changing climate. Extra CO2 is good for plants...to up to a point. For plants in wetlands its a race between rising sea levels and extra CO2.  Emmanuel Tergemina, Ahmed F. Elfarargi, Paulina Flis, Andrea Fulgione, Mehmet Göktay, Célia Neto, Marleen Scholle, Pádraic J. Flood, Sophie-Asako Xerri, Johan Zicola, Nina Döring, Herculano Dinis, Ute Krämer, David E. Salt, Angela M. Hancock. A two-step adaptive walk rewires nutrient transport in a challenging edaphic environment. Science Advances, 2022; 8 (20) DOI: 10.1126/sciadv.abm9385 Chunwu Zhu, J. Adam Langley, Lewis H. Ziska, Donald R. Cahoon, J. Patrick Megonigal. Accelerated sea-level rise is suppressing CO 2 stimulation of tidal marsh productivity: A 33-year study. Science Advances, 2022; 8 (20) DOI: 10.1126/sciadv.abn0054

Off the Bench
Rethinking Laboratory Medicine Education

Off the Bench

Play Episode Listen Later May 27, 2022 62:21


Have you ever sat in a lecture and tried your best to hide that you're gently dosing off? Do you shudder at the thought of having to remember to coagulation cascade? In this episode, hosts Galina Dronova and Justin Hanenberg discuss how we can transform laboratory medicine education, whether in the classroom or on the bench, from procedural knowledge to conceptual. With our guest experts, Dr. Justin Kreuter and Theresa Malin, MEd, MLS(ASCP)CM, we flip the script from creating short term memory retention to a story of meaning. -- References Brown, P., Roediger, H. McDaniel, M. (2014) Make it stick. The science of successful learning. The Belknap Press of Harvard University Press. Cutrer, W. B., Miller, B., Pusic, M. V., Mejicano, G., Mangrulkar, R. S., Gruppen, L. D., Hawkins, R. E., Skochelak, S. E., & Moore, D. E. (2017). Fostering the development of master adaptive learners: A conceptual model to guide skill acquisition in medical education. Academic Medicine, 92(1), 70-75. DOI: 10.1097/ACM.0000000000001323 Cutrer, W. B., Atkinson, H. G., Friedman, E., Deiorio, N., Gruppen, L. D., Dekhtyar, M., Pusic. M. (2018). Exploring the characteristics and context that allow Master Adaptive Learners to thrive. Medical Teacher, 40(8), 791-796. DOI: 10.1080/0142159X.2018.1484560 Six Strategies for Effective Learning. The Learning Scientists. https://www.learningscientists.org/downloadable-materials

Beyond the Abstract
Revving Up the CAR T: Fighting Fibrosis with Gene Therapy

Beyond the Abstract

Play Episode Listen Later May 27, 2022 19:48


CAR T cells have been engineered to treat everything from cancer to scarring in the heart. However, one major barrier to wide-spread therapy is the fact that T cells have to be removed from the patient, engineered, and then putting them back in the patient. But what if we could create a drug that makes CAR T cells inside a patient's own body? This type of one-size-fits-all approach could be much more efficient. On this episode of Beyond the Abstract, Derek and Dan discuss how scientists at the University of Pennsylvania have successfully created CAR T cells to treat scarring in the heart with the simple injection of a drug. Using state-of-the-art gene therapy, they are able to temporarily transform T cells into soldiers to fight scarring in the heart. Rurik et al. CAR T cells produced in vivo to treat cardiac injury. Science, January 2022. DOI: https://doi.org/10.1126/science.abm0594 (10.1126/science.abm0594) The information presented here is not medical advice. Consult your physician on any questions regarding your personal health.

PsychEd: educational psychiatry podcast
PsychEd Episode 44: Reproductive Psychiatry with Dr. Tuong Vi Nguyen

PsychEd: educational psychiatry podcast

Play Episode Listen Later May 27, 2022 33:25


Welcome to PsychEd, the psychiatry podcast for medical learners, by medical learners. This episode covers perinatal psychiatry with Dr. Tuong Vi Nguyen, Assistant Professor, Department of Psychiatry, Faculty of Medicine and Health Sciences, McGill University and Scientist, RI-MUHC, Brain Repair and Integrative Neuroscience (BRaIN) Program, Centre for Outcomes Research and Evaluation.    The learning objectives for this episode are as follows:   By the end of this episode, you should be able to… Define the field of reproductive psychiatry Discuss the possible neurobiological pathways impacting mood and cognition during the reproductive cycle of women.  Discuss the influence of sociocultural gender roles on psychopathology.    List the DSM-V diagnostic criteria of premenstrual dysphoric disorder. Recall the epidemiology of premenstrual dysphoric disorder. Describe the steps in the diagnostic evaluation for premenstrual dysphoric disorder. List lifestyle and psychopharmacologic interventions for premenstrual dysphoric disorder. Discuss common mental health concerns during the perimenopausal period. Guest: Dr. Tuong Vi Nguyen   Hosts: Nima Nahiddi (PGY4), Audrey Le (PGY1), and Arielle Geist (PGY2)    Audio editing by: Audrey Le   Show notes by: Arielle Geist    Interview content: Introduction - 00:00 Learning objectives - 01:00 Defining the field of perinatal psychiatry - 01:50 Discussing neurobiological pathways impacting mood and cognition during the reproductive cycle - 02:47 The influence of sociocultural gender roles on psychopathology -05:28 DSM-V criteria of premenstrual dysphoric disorder - 11:18 Epidemiology of premenstrual dysphoric disorder - 13:40 Diagnostic evaluation of premenstrual dysphoric disorder - 14:38 Management of premenstrual dysphoric disorder  Pharmacologic - 17:45 Lifestyle - 24:15 Perimenopausal period - 24:45 Closing comments - 31:39   Resources: Brzezinski, A., Brzezinski-Sinai, N.A., & Seeman, M.V. (2017). Treating schizophrenia during menopause. Menopause, 24(5), 582-588. doi: 10.1097/GME.0000000000000772. Epperson, C.N., Steiner, M., Hartlage, A., Eriksson, E., Schmidt, P.J., Jones, I., & Yonkers, K.A. (2012). Premenstrual dysphoric disorder: evidence for a new category for DSM-5. The American Journal of Psychiatry, 169(5), 465-475. DOI: 10.1176/appi.ajp.2012.11081302 Marsh, W.K., Gershenson, B., & Rothschild, A.J. (2015). Symptom severity of bipolar disorder during the menopausal transition. International Journal of Bipolar Disorders, 3(1), 35. DOI: 10.1186/s40345-015-0035-z Soares, C.N., Almeida, O.P.,  Joffe, H., & Cohen, L.S. (2001). Efficacy of estradiol for the treatment of depressive disorders in perimenopausal women a double-blind, randomized, placebo-controlled trial. Archives of General Psychiatry, 58(6), 529-534. doi:10.1001/archpsyc.58.6.529 Weber, M.T., Maki, P.M., & McDermott, M.P. (2013). Cognition and mood in perimenopause: A systematic review and meta-analysis. The Journal of Steroid Biochemistry and Molecular Biology, 142, 90-98. https://doi.org/10.1016/j.jsbmb.2013.06.001   References: Kornstein S.G., & Clayton, A.H. (2004). Sex differenes in neuroendocrine and neurotransmitter systems. In Women's mental health: A comprehensive textbook (pp.3-30). Guilford Press.  Chrisler, J. C., & Johnston-Robledo, I. (2002). Raging hormones?: Feminist perspectives on premenstrual syndrome and postpartum depression. In M. Ballou & L. S. Brown (Eds.), Rethinking mental health and disorder: Feminist perspectives (pp. 174–197). Guilford Press. American Psychiatric Association. (2013). Depressive disorders. In Diagnostic and statistical manual of mental disorders (5th ed.). https://doi.org/10.1176/appi.books.9780890425596.   CPA Note: The views expressed in this podcast do not necessarily reflect those of the Canadian Psychiatric Association.   For more PsychEd, follow us on Twitter (@psychedpodcast), Facebook (PsychEd Podcast), and Instagram (@psyched.podcast). You can provide feedback by email at psychedpodcast@gmail.com. For more information, visit our website at psychedpodcast.org.

Your Fertility Pharmacist
Infertility Treatment & Workplace Harassment

Your Fertility Pharmacist

Play Episode Listen Later May 26, 2022 10:38


ResourcesCDC-State-Specific Assisted Reproductive Technology Surveillance. https://www.cdc.gov/art/state-specific-surveillance/index.html Accessed May 20, 2022.Herbenick D, van Anders SM, Brotto LA, Chivers ML, Jawed-Wessel S, Galarza J. Sexual Harassment in the Field of Sexuality Research. Arch Sex Behav. 2019;48(4):997-1006. doi:10.1007/s10508-019-1405-x brilliant paper!Horvath K. Does Bragdon v. Abbott Provide the Missing Link for Infertile Couples Seeking Protection under the ADA?, 2 DePaul J Health Care L. 1999; 819 https://via.library.depaul.edu/jhcl/vol2/iss4/4 Accessed May 20, 2022. Legal background for asserting workplace protection during infertility treatments. Ikemoto Y, Kuroda K, Endo M, et al. Analysis of severe psychological stressors in women during fertility treatment: Japan-Female Employment and Mental health in Assisted reproductive technology (J-FEMA) study. Arch Gynecol Obstet. 2021;304(1):253-261. doi:10.1007/s00404-020-05923-6Imai Y, Endo M, Kuroda K, et al. Risk factors for resignation from work after starting infertility treatment among Japanese women: Japan-Female Employment and Mental health in Assisted reproductive technology (J-FEMA) study [published online ahead of print, 2020 Dec 3]. Occup Environ Med. 2020;78(6):426-432. doi:10.1136/oemed-2020-106745Spiggle T. Workplace Rights for Those Suffering From Infertility. Law blog published May 2015. https://spigglelaw.com/workplace-rights-for-those-suffering-from-infertility/#:~:text=According%20to%20the%20United%20States,the%20employer%20violated%20the%20ADA. Accessed May 20, 2022. Law blog summarizing legal protections for infertility care. Volk H, Hadler M. Work Orientations and Perceived Working Conditions across Countries: Results from the 2015 ISSP Survey. International Journal of Sociology. 2018; 48:2, 103-123, DOI: 10.1080/00207659.2018.1446116Ueda Y, Endo M, Kuroda K, et al. Risk factors for infertility treatment-associated harassment among working women: a Japan-Female Employment and Mental health in assisted reproductive technology (J-FEMA) study [published online ahead of print, 2022 May 13]. Int Arch Occup Environ Health. 2022;10.1007/s00420-022-01872-6. doi:10.1007/s00420-022-01872-6

Oncotarget
Paper Spotlight: Tool Uses NF-κB Activity to Classify HPV+ Head and Neck Cancer

Oncotarget

Play Episode Listen Later May 26, 2022 7:14


Listen to a blog summary of a trending research paper published in Volume 13, entitled, “NF-κB over-activation portends improved outcomes in HPV-associated head and neck cancer.” ______________________________ Over the last 10 years in the United States, the human papillomavirus (HPV) has caused more head and neck squamous cell carcinomas (HNSCC) than uterine cervical cancers. Primarily caused either by exposure to HPV or to ethanol or tobacco, HNSCC is a disease that impairs fundamental tissues involved in respiration, speech and digestion. HPV-positive and -negative HNSCC have contrasting clinical, epidemiological and histological features. “A major discovery in the recent past is that HPV associated HNSCC have improved survival compared to tobacco associated tumors.” Therefore, treating HNSCC in accordance with HPV status is crucial for avoiding unnecessarily harsh therapeutic side effects in HPV+ HNSCC patients. However, while oncologic outcomes among patients with HPV+ HNSCC are generally favorable, approximately 30% experience a more aggressive disease course and recurrence. Coupled with increasing incidence worldwide, this highlights a growing need for the development of effective clinical stratification tools to accurately identify HPV+ HNSCC patients who have a good or poor prognosis. In a new study, researchers—from Columbia University, University of Illinois Cancer Center, University of North Carolina at Chapel Hill, and Yale School of Medicine—developed a new tool aimed at better classifying HPV+ HNSCC patients with good or poor prognosis in an effort to personalize treatment and improve patient outcomes. Their trending research paper was published in Oncotarget on May 24, 2022, and entitled, “NF-κB over-activation portends improved outcomes in HPV-associated head and neck cancer.” “To improve on genomic classification, we designed this study to provide a foundation for development of NF-κB related, RNA based classification strategies to better identify HPV+ HNSCC patients with good or poor prognosis that could potentially aid in future efforts towards treatment personalization.” Full blog - https://www.oncotarget.org/2022/05/26/new-tool-uses-nf-%ce%bab-activity-to-classify-hpv-head-and-neck-cancer/ DOI - https://doi.org/10.18632/oncotarget.28232 Correspondence to - Wendell G. Yarbrough - dell@med.unc.edu, and Natalia Issaeva - natalia.isaeva@med.unc.edu Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28232 Press release - https://www.oncotarget.com/news/pr/oncotarget-nf-b-over-activation-portends-improved-outcomes-in-hpv-associated-head-and-neck-cancer/ Keywords - HPV, head and neck cancer, CYLD, TRAF3, NF-κB About Oncotarget Oncotarget is a peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/OncotargetYouTube LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Oncotarget is published by Impact Journals, LLC: https://www.ImpactJournals.com Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957

Discovery Matters
55. The injustice of disease burden and access to vaccines

Discovery Matters

Play Episode Listen Later May 26, 2022 20:48


The pandemic has been a global issue, which has benefitted from the coming together of industry, pharma, academia, non-governmental and governmental support. What the pandemic has also brought into sharp focus is the global imbalance access to healthcare and health inequity between the Global North and Global South. For this important conversation, we are joined by Professor Linda-Gail Bekker, Chief Operating Officer of the Desmond Tutu HIV Foundation about the current situation with HIV and TB in Africa, and the impact COVID-19 has had on patients already suffering from communicable diseases. So, what can we do? Lenias Hwenda, founder and CEO of Medicines for Africa, explains the additional problems of access to medicines and potential solutions for global vaccine inequity, working to make medicines as inexpensive as possible, and improving the supply chain. Related reading – Dzau, V.J., Balatbat, C.A., Offodile II, A.C., Closing the global vaccine equity gap: equitably distributed manufacturing. The Lancet. 2022;399(10339): 1924-1926. DOI: https://doi.org/10.1016/S0140-6736(22)00793-0 The Global Biopharma Resilience Index How localizing manufacturing is helping the Middle East take control of its vaccine supply? Keywords: equitable access, HIV, human immunodeficiency viruses, Lentivirus, medicines, pandemic, countries, vaccine, TB, epidemic, Africa, supply chain, communicable diseases, middle-income countries, access, low-income countries, Global North, Global South, disease burden.

Oncotarget
Press Release: NF-κB Over-Activation Portends Improved Outcomes in HPV+ HNSCC

Oncotarget

Play Episode Listen Later May 25, 2022 4:10


BUFFALO, NY- May 25, 2022 – A new research paper was published in Oncotarget, entitled, “NF-κB over-activation portends improved outcomes in HPV-associated head and neck cancer.” Head and neck squamous cell carcinoma (HNSCC) is a devastating disease that impairs fundamental tissues involved in respiration, phonation and digestion. HNSCC is primarily caused by exposure to either ethanol and tobacco or the human papillomavirus (HPV). Among patients with HPV+ HNSCC, there is a growing clinical demand to develop robust stratification tools to accurately identify patients with good or poor prognosis. “While oncologic outcomes for HPV+ HNSCC are generally favorable, treatment paradigms developed for HPV-negative disease burden many survivors of HPV+ HNSCC with lifelong debilitating treatment-associated side effects [10]. On the other hand, ~30% of HPV+ HNSCC patients exhibit a more aggressive disease course and suffer recurrence [11, 12].” Somatic mutations or deletions in TRAF3 or CYLD identified a subset of HPV+ HNSCC associated with improved outcome. A cross talk between canonical and non-canonical NF-κB signaling suggests that TRAF3 and CYLD affect both NF-κB pathways. “Herein, we demonstrate that an RNA-based classifier trained on tumors harboring these mutations may improve prognostic classification (Figure 3A, 3B, Figure 4B and Supplementary Figure 1).” To improve on genomic classification, researchers designed the current study to provide a foundation for development of NF-κB related, RNA based classification strategies to better identify HPV+ HNSCC patients with good or poor prognosis that could potentially aid in future efforts towards treatment personalization. “This report validates and expands on our findings that significant expression changes related to NF-κB activity occur in the subset of HPV+ HNSCC tumors marked by TRAF3 or CYLD mutations. We are planning future studies investigating the importance of ‘long-tail' mutations in the NF-κB pathway which might further illuminate the origins of NF-κB dysregulation in HPV+ HNSCC.” “Given that methods to identify patients for deintensified therapy are imperfect, our improved classifiers may serve as prognostic biomarker to help clinicians with therapeutic decisions.” DOI: https://doi.org/10.18632/oncotarget.28232 Correspondence to: Wendell G. Yarbrough and Natalia Issaeva Email: dell@med.unc.edu and natalia.isaeva@med.unc.edu Keywords: HPV, head and neck cancer, CYLD, TRAF3, NF-κB About Oncotarget: Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, visit Oncotarget.com and connect with us on social media: Twitter – https://twitter.com/Oncotarget Facebook – https://www.facebook.com/Oncotarget YouTube – www.youtube.com/c/OncotargetYouTube Instagram – https://www.instagram.com/oncotargetjrnl/ LinkedIn – https://www.linkedin.com/company/oncotarget/ Pinterest – https://www.pinterest.com/oncotarget/ LabTube – https://www.labtube.tv/channel/MTY5OA SoundCloud – https://soundcloud.com/oncotarget For media inquiries, please contact: media@impactjournals.com.

Herpetological Highlights
111 Steps Towards Turtle Rehabilitation

Herpetological Highlights

Play Episode Listen Later May 24, 2022 29:12


Sometimes turtles can get caught up in nets and other sticky situations. Rehabilitation can help out these injured or exhausted turtles… but how do they fare when they are released back into the big wide ocean? Become a Patreon: https://www.patreon.com/herphighlights Full reference list available here: http://www.herphighlights.podbean.com Main Paper References: Robinson DP, Hyland K, Beukes G, Vettan A, Mabadikate A, Jabado RW, Rohner CA, Pierce SJ, Baverstock W. 2021. Satellite tracking of rehabilitated sea turtles suggests a high rate of short-term survival following release. PLOS ONE 16:e0246241. DOI: 10.1371/journal.pone.0246241. Other Mentioned Papers/Studies: BM Marshall, CT Strine, CS Fukushima, P Cardoso, MC Orr, AC Hughes. 2022. Searching the web builds fuller picture of arachnid trade. Communication Biology. DOI: 10.1038/s42003-022-03374-0 Szymura, J. M., Spolsky, C., & Uzzoll, T. (1985). Concordant change in mitochondrial and nuclear genes in a hybrid zone between two frog species (genus Bombina). Experientia, 41(11), 1469-1470. Other Links/Mentions: Bombina call from Explore Croatia - https://www.youtube.com/watch?v=wvMYU8drjg0 Music: Intro/outro – Treehouse by Ed Nelson Species Bi-week theme – Mike Mooney Other Music – The Passion HiFi, www.thepassionhifi.com

Emergency Medical Minute
Podcast 784: Wastewater Surveillance for COVID

Emergency Medical Minute

Play Episode Listen Later May 24, 2022 5:06


Contributor: Jared Scott, MD Educational Pearls: About 50% of those infected with SARS-CoV-2 will shed the virus in their feces   Wastewater surveillance can be used to track COVID burden, which may be easier than collating test data from multiple hospitals across a region  Viral shedding begins 5-7 days prior to symptom onset, so wastewater data can be used to anticipate outbreaks and inform policy and public health initiatives  Some existing limitations to wastewater surveillance include: Reporting by counties were water sources may be mixed Septic tanks and other closed water systems will not be counted Not all those infected will shed the virus References Weidhaas J, Aanderud ZT, Roper DK, et al. Correlation of SARS-CoV-2 RNA in wastewater with COVID-19 disease burden in sewersheds. Sci Total Environ. 2021;775:145790. doi:10.1016/j.scitotenv.2021.145790 Kirby AE, Walters MS, Jennings WC, et al. Using Wastewater Surveillance Data to Support the COVID-19 Response — United States, 2020–2021. MMWR Morb Mortal Wkly Rep 2021;70:1242–1244. DOI: http://dx.doi.org/10.15585/mmwr.mm7036a2 Covid-19 monitoring in wastewater. Colorado COVID-19 Updates. https://covid19.colorado.gov/covid-19-monitoring-in-wastewater. Accessed May 21, 2022. Summarized by Kirsten Hughes, MS4 | Edited by John Spartz, MD, MPH & Erik Verzemnieks, MD   The Emergency Medical Minute is excited to announce that we are now offering AMA PRA Category 1 credits™ via online course modules. To access these and for more information, visit our website at https://emergencymedicalminute.org/cme-courses/ and create an account.  Donate to EMM today!

KZMU News
Friday May 20, 2022

KZMU News

Play Episode Listen Later May 20, 2022 24:53


Every year a number of Moabites injure themselves doing activities they are passionate about. Paying for medical bills and possibly dealing with trauma can be difficult. But there's a growing number of options for help, from grants for medical bills to therapists dedicated to post-accident trauma. Plus, a nationwide formula shortage is affecting parents and their children across the country, including Southeastern Utah. // Plus, the Weekly News Reel where where we check in with reporters on their latest stories of the Moab area. Doug McMurdo of The Times-Independent talks 20 years for thrift store WabiSabi, Moab Regional's recovery center and former county commissioner Curtis Wells heading the state's Community Impact Board. Alison Harford of the Moab Sun News discusses Moab Bee Inspired Gardens, a local law enforcement officer receiving a national award, and the return of the Moab Arts Festival. // Show Notes // Photo: Hunter Kessler spent nearly three weeks in a Grand Junction hospital after a canyoneering accident. He says he's struggled to return to the sport, but is working on trusting his equipment again. // High Fives Foundation https://highfivesfoundation.org // The White House: Biden Administration Approves Operation Fly Formula Mission https://www.whitehouse.gov/briefing-room/statements-releases/2022/05/19/biden-administration-approves-first-operation-fly-formula-mission/ // HHS: Helping Families Find Formula During the Infant Formula Shortage https://www.hhs.gov/formula/index.html // Academy of Breastfeeding Medicine re: Shortage of Breastmilk Substitutes https://www.bfmed.org/statement-on-shortage-of-breastmilk-substitutes // Weekly News Reel Mentions // The Times-Independent: ‘Much more than a thrift store' https://www.moabtimes.com/articles/much-more-than-a-thrift-store/ // The Times-Independent: MRH substance abuse clinic set to open https://www.moabtimes.com/articles/mrh-substance-abuse-clinic-set-to-open/ // The Times-Independent: Moab's Wells to head Community Impact Board https://www.moabtimes.com/articles/moabs-wells-to-head-community-impact-board/ // The Times-Independent: Commission to lobby DOI on SITLA swap https://www.moabtimes.com/articles/commission-to-lobby-doi-on-sitla-swap/ // Moab Sun News: Bee Inspired Gardens project buzzes to life https://moabsunnews.com/2022/05/19/bee-inspired-gardens-project/ // Moab Sun News: Moab BLM law enforcement officer Cody Marsh receives national award https://moabsunnews.com/2022/05/19/cody-marsh-national-award/ // Moab Sun News: ‘This is going to be a fabulous year' https://moabsunnews.com/2022/05/19/moab-arts-festival-2022/

Oncotarget
Press Release: Anti-Cancer Drug Profiling With CancerOmicsNet

Oncotarget

Play Episode Listen Later May 20, 2022 3:32


BUFFALO, NY- May 19, 2022 – A new research paper was published in Volume 13 of Oncotarget, entitled, “CancerOmicsNet: a multi-omics network-based approach to anti-cancer drug profiling.” Researchers from Louisiana State University developed CancerOmicsNet—a graph neural network model to predict the growth rate of a cancer cell line after drug treatment. “CancerOmicsNet is more advanced than many deep learning techniques operating in the Euclidean space [47], because it extracts knowledge directly from biological networks providing a more adequate representation of complex diseases such as cancer.” CancerOmicsNet integrates multiple heterogeneous data, such as biological networks, genomics, inhibitor profiling, and gene-disease associations, into a unified graph structure. This novel method utilizes compact, cancer-specific networks constructed from protein-protein interactions, differential gene expression, disease-gene association, and drug inhibition data. “In order to evaluate the performance of CancerOmicsNet, we conducted a cross-validation at the tissue level by removing from model training all cell lines originating from a particular tissue and then analyzing the accuracy for these cell lines.” In this study, the researchers carefully evaluated the generalizability of CancerOmicsNet in a series of cross-validation benchmarks against different tumor tissues. Encouragingly, the cross-validated accuracy of CancerOmicsNet at the tissue level was significantly higher than those measured for other approaches on the same data. “The performance of CancerOmicsNet, properly cross-validated at the tissue level, is 0.83 in terms of the area under the receiver operating characteristics, which is notably higher than those measured for other approaches.” The researchers specify that the applicability of CancerOmicsNet is presently limited to kinase inhibitors, while alternative methods are applicable to other classes of therapeutics as well. “Overall, CancerOmicsNet offers a high performance and the desired generalizability in the prediction of the effect of kinase-targeted therapies on the cancer cell growth.” DOI: https://doi.org/10.18632/oncotarget.28234 Correspondence to: Michal Brylinski – Email: michal@brylinski.org Keywords: cancer growth rate, kinase inhibitors, differential gene expression, gene-disease association, cancer-specific networks About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, visit Oncotarget.com and connect with us on social media: Twitter – https://twitter.com/Oncotarget Facebook – https://www.facebook.com/Oncotarget YouTube – www.youtube.com/c/OncotargetYouTube Instagram – https://www.instagram.com/oncotargetjrnl/ LinkedIn – https://www.linkedin.com/company/oncotarget/ Pinterest – https://www.pinterest.com/oncotarget/ LabTube – https://www.labtube.tv/channel/MTY5OA SoundCloud – https://soundcloud.com/oncotarget For media inquiries, please contact: media@impactjournals.com.

The Gary Null Show
The Gary Null Show - 05.20.22

The Gary Null Show

Play Episode Listen Later May 20, 2022 58:29


Blueberries can lower the risk of cardiovascular disease in postmenopausal women with high blood pressure Colorado State University, May 19 2022 Consuming blueberries can lower the risk of cardiovascular disease in postmenopausal women with high blood pressure, according to new research by Colorado State University faculty member Sarah Ardanuy Johnson. Consumption of 22 grams of freeze dried blueberry powder (equivalent to about 1 cup of fresh blueberries) mixed with water taken daily for 12 weeks improved the function of the inner lining of blood vessels (called the endothelium), according to preliminary findings of a study. They performed a randomized, double-blind, placebo-controlled, parallel-arm clinical trial in 43 estrogen-deficient postmenopausal women aged 45-65 years with elevated blood pressure or stage 1-hypertension. Johnson's research team used freeze-dried blueberries to retain the polyphenols as much as possible, and to allow for the study to be double-blind, meaning that neither the investigators nor the study participants knew whether they were getting the treatment (blueberry) or placebo.  Johnson said the team observed increases in blood metabolites that are products of metabolism of anthocyanins (polyphenols found in blueberries that give them their blue color) and metabolism of polyphenols by the gut microbiome.  Diet plays key role in ADHD symptoms in children Ohio State University, May 20, 2022 Here's a good reason for children with attention deficit hyperactivity disorder (ADHD) to eat their fruits and vegetables: It may help reduce inattention issues, a new study suggests. Results showed that kids who consumed more fruits and vegetables showed less severe symptoms of inattention, said Irene Hatsu, associate professor of human nutrition at The Ohio State University. The study that evaluated the effectiveness of the supplement showed that children who took the micronutrients were three times as likely to show significant improvement in their ADHD and emotional dysregulation symptoms than those who took a placebo.  Higher dose of melatonin improved sleep in older adults Harvard University, May 19, 2022 In a small study of healthy adults aged 55 and older, 5 mg of melatonin increased total sleep time compared to a placebo. Researchers conducted the study in 24 healthy, older adults to evaluate whether a high-doseor a low-dose melatonin supplement could improve sleep. The team found that the higher dose had a significant impact, increasing total sleep time compared to placebo by more than 15 minutes for nighttime sleep and by half an hour for daytime sleep. Results are published in the Journal of Pineal Research.  The body naturally produces the hormone melatonin, which helps regulate a person's sleep-wake cycle with night and day. Melatonin levels peak at night. But among older people, levels of the hormone are often lower. The team found that the low dose of melatonin did not lead to a statistically significant change in overall sleep time and that the changes that were seen were when sleep was scheduled during the biological day. Participants taking the 5 mg dose had a significant increase in total sleep time and sleep efficiency regardless of whether sleep was scheduled during the day or night. Sound Waves Boost Older Adult's Memory, Deep Sleep Northwestern University, May 14, 2022 Gentle sound stimulation—such as the rush of a waterfall—synchronized to the rhythm of brain waves significantly enhanced deep sleep in older adults and improved their ability to recall words. This is according to a Northwestern Medicine study. Deep sleep is critical for memory consolidation. But beginning in middle age, deep sleep decreases substantially, which scientists believe contributes to memory loss in aging. The sound stimulation significantly enhanced deep sleep in participants and their scores on a memory test. The degree of slow wave sleep enhancement was related to the degree of memory improvement, suggesting slow wave sleep remains important for memory, even in old age. Mulberry extract may ‘activate' brown fat, help treat obesity Chinese Academy of Sciences, May 9, 2022 Researchers from the Chinese Academy of Sciences say obesity can be treated by using a natural compound in mulberries that “activates” brown fat.The compound, known as rutin, was found to have weight loss properties in a study published in The FASEB Journal. Researchers say this may not only be able to help treat obesity, but related diseases associated with excessive weight gain.”The beneficial effects of rutin on BAT-mediated metabolic improvement have evoked a substantial interest in the potential treatment for obesity and its related diseases, such as diabetes,” researcher Wan-Zhu Jin said in a press release. During the experiment, supplemental rutin was added to the drinking water of both groups. Researchers observed improved glucose homeostasis in both cohorts. The investigators concluded the rutin improved metabolic functions in the mice. Scientists are confident similar remedies can be used to treat obesity in humans. Psychedelic drugs promote neural plasticity in rats and flies University of California Davis, May 12, 2022  Psychedelic drugs may have mind-altering powers in the physical sense, too. A new study, published in the journal Cell Reports, found psychedelics, specifically DOI, DMT, and LSD, can change brain cells in rats and flies, making neurons more likely to branch out and connect with one another. The work supports the theory that psychedelics could help to fight depression, anxiety, addiction, and post-traumatic stress disorder. “These are some of the most powerful compounds known to affect brain function, it's very obvious to me that we should understand how they work,” says senior author David E. Olson, assistant professor at the University of California, Davis. The idea that depression stems from imbalanced brain chemistry remains popular, but recent studies have revealed evidence that depression manifests as structural changes in brain circuits or atrophy in parts of the brain. This doesn't mean neurons die off during depression, but that neurites retract. Neurites are the sections—either axons or dendrites—of a neuron that project out to bridge the gap between two neurons at the synapse to facilitate communication. “One of the hallmarks of depression is that the neurites in the prefrontal cortex—a key brain region that regulates emotion, mood, and anxiety—those neurites tend to shrivel up,” says Olson. These brain changes also appear in cases of anxiety, addiction, and post-traumatic stress disorder. In their paper, Olson and colleagues tested psychedelics and showed some psychedelics tested, including LSD, proved to be more potent and efficacious in promoting neurite growth. Videos : 1. Whoa! Rand Paul spitting truth bombs like a rocket launcher 2. Preparing for

Herpetological Highlights
110 Snakes - Ant-mothers or Ant-Eaters

Herpetological Highlights

Play Episode Listen Later May 19, 2022 34:16


We've talked about ants being the victims of herpetofauna depredation, but what about snakes that are friends to ants? This episode we chat about a paper detailing the antics of an “ant-mother”. Become a Patreon: https://www.patreon.com/herphighlights Full reference list available here: http://www.herphighlights.podbean.com Main Paper References: Jono T, Kojima Y, Mizuno T. 2019. Novel cooperative antipredator tactics of an ant specialized against a snake. Royal Society Open Science 6:190283. DOI: 10.1098/rsos.190283. Species of the Bi-Week: de Oca AN-M, Castresana-Villanueva N, Canseco-Márquez L, Campbell JA. 2022. A New Species of Xenosaurus (Squamata: Xenosauridae) from the Sierra de Juárez of Oaxaca, Mexico. Herpetologica 78. DOI: 10.1655/Herpetologica-D-21-00041.1. Other Mentioned Papers/Studies: Hodges, CW, Marshall, BM, Hill, JG, Strine, CT. 2022. Malayan kraits (Bungarus candidus) show affinity to anthropogenic structures in a human dominated landscape. Scientific reports, 12(1), pp.1-16. DOI: 10.1038/s41598-022-11255-z Knolle, F, Goncalves, RP, Morton, AJ. 2017. Sheep recognize familiar and unfamiliar human faces from two-dimensional images. Royal Society Open Science, 4(11), 171228. DOI: 10.1098/rsos.171228 Other Links/Mentions: Wolves and raven playing: https://www.yellowstone.org/naturalist-notes-wolves-and-ravens/ Ant video from Jono et al., - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731735/bin/rsos190283supp2.avi Music: Intro/outro – Treehouse by Ed Nelson Species Bi-week theme – Mike Mooney Other Music – The Passion HiFi, www.thepassionhifi.com