Organ system within humans and other animals pertaining to the stomach and intestines
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This week Doug and Alice spend most of the episode becoming educated in poops and adjacent fields, thanks to an old, forgotten birthday gift. When they're not doing that, Doug is finally learning some new music while Alice is wondering if her memory has been partially erased by the FBI.Other discussion topics may include:- Trying to make "going giraffe" happen- Why you don't want to be attacked by The Green Goblin- Unassertive cats and the clean beds they leave behind- New game show idea: "Is This Blood or Is This Red Meat?"- Intestinal autonomy
250908 Lunes Limpieza Intestinal by Neyda Carballo-Ricardo
Mitchell Thompson is a gym owner, certified nutritionist, author, and health consultant who reversed his Crohn's disease without medication or surgery by adopting a ketovore diet. After years of battling symptoms and facing the conventional medical route, Mitchell used a meat-based approach to achieve full remission and now helps others take control of their health through nutrition, biomechanics, and lifestyle coaching. He is the author of Healthy Made Easy, a practical nutrition guide that simplifies eating for optimal health, and has also written three children's books — The Fun Adventures of Willie & Abel, The Fun Adventures of Hope & Grace, and The Fun Adventures of Chance & Chase — which blend creativity and positive values for young readers. Mitchell recently released a documentary sharing his Crohn's recovery journey, challenging mainstream dietary advice, and showcasing the power of species-appropriate eating. Instagram: https://www.instagram.com/mitch.tomson YouTube: https://www.youtube.com/@SelfSustainedTraining Documentary - How Keto Cured My Chron's: https://www.youtube.com/watch?v=jFP3tb3DaJI Timestamps: 00:00 Trailer 00:39 Introduction 04:29 Crohn's disease diagnosis 06:33 Severe Crohn's and colitis symptoms 12:06 Unhealthy diet and medical advice 14:55 Metabolic insights during Crohn's journey 17:40 Avoiding biologics for IBD health 20:59 Doubting medical advice and success 24:29 Carb addiction and dietary risks 28:17 Documentary outreach and impact 32:12 Intestinal strictures and DNA results 35:51 Coaching transformation 37:09 Documentary's impact on health awareness 40:43 Medical community frustration 42:13 Where to Find Mitchell Join Revero now to regain your health: https://revero.com/YT Revero.com is an online medical clinic for treating chronic diseases with this root-cause approach of nutrition therapy. You can get access to medical providers, personalized nutrition therapy, biomarker tracking, lab testing, ongoing clinical care, and daily coaching. You will also learn everything you need with educational videos, hundreds of recipes, and articles to make this easy for you. Join the Revero team (medical providers, etc): https://revero.com/jobs #Revero #ReveroHealth #shawnbaker #Carnivorediet #MeatHeals #AnimalBased #ZeroCarb #DietCoach #FatAdapted #Carnivore #sugarfree Disclaimer: The content on this channel is not medical advice. Please consult your healthcare provider.
In this episode, we are joined by Helmut Schmutz. Helmut developed the original, patented diamine oxidase formulation, and his work serves as a driving force in the innovation at OmneDiem. Topics: 1. Histamine- Exogenous versus endogenous histamine.- Mast cells as a source of endogenous histamine.- Endogenous histamine signaling needed for diverse physiological functions.- Intestinal microbes as a source of histamine production.- Food as a source of histamine.2. Dietary Histamine- Foods higher in histamine.- Histamine in food and taste.- Histamine-rich foods and histamine liberators. 3. Histamine Intolerance- Intolerance versus sensitivity versus allergy- Hallmark symptoms of histamine intolerance.- Histamine intolerance and diamine oxidase enzyme insufficiency.4. Diamine Oxidase Supplementation- OmneDiem's enzyme preservation and HDUs.- Where the supplement acts; protection from the gastric environment.- Timing of supplementation.5. Histamine and Women's Health- Hormonal fluctuations and effects on endogenous histamine release or clearance.- Menopause.6. OmneDiemExplore OmneDiem®'s Histamine Digest® and Histamine Digest® PureMAX : Use code STXAL9VI for 15% off.Explore Histamine Digest® Histamine Complete with DAO, Vitamin C, Quercetin, Bromelain, and Stinging Nettle Root Extract: Use code STXAL9VI for 15% off.Thanks for tuning in!Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessVisit synthesisofwellness.com
En lo último en salud y fitness edición de agosto 2025, damos un paseo por las últimas tendencias, investigaciones y noticias en el mundo de la salud y el fitness.Este mes traemos un episodio cargado de temas que van a cambiar la forma en que piensas sobre tu entrenamiento y tu salud.Vamos a hablar de algo que seguro te has preguntado alguna vez: ¿entrenar en ayunas te hace perder músculo o es solo un mito? También veremos qué hay de cierto en toda esa publicidad sobre probióticos para atletas, y si realmente necesitas gastar tu dinero en ellos.Además, analizaremos a la creatina, pero no solo como el suplemento estrella para tus músculos: resulta que podría tener efectos sorprendentes en tu cerebro, especialmente contra el Alzheimer. Y para cerrar, desmontamos uno de los grandes mitos de la medicina moderna: que la diabetes tipo 2 es una condición de por vida.Atajos Del Episodio02:25 - Entrenar en Ayunas: ¿Estás Quemando Músculo o Quemando Mitos?107:32 - Probióticos para Atletas: ¿La Revolución Intestinal o Solo Mucho Ruido y Pocos Resultados?212:20 - Creatina: El Suplemento para Músculos que Podría Rescatar tu Cerebro316:32 - Diabetes Tipo 2: ¿Sentencia de por Vida o Problema Reversible?420:16 - Alimentos Ultraprocesados: La Ruta Directa de la Despensa al Hígado Graso5Referencias:1. Vieira, A. F. & Blanco-Rambo…, E. Impact of Overnight Fasted State Versus Fed State on Adaptations to Resistance Training: A Randomized Clinical Trial. … Journal of Sport … (2025).2. Shirkoohi, N. M., Mohammadi, H. & Gallaly…, D. Q. The effects of probiotic supplementation on body composition, recovery following exercise‐induced muscle damage, and exercise performance: A systematic review …. Physiological … (2025).3. Smith, A. N., Choi, I. Y., Lee, P. & Sullivan…, D. K. Creatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition. … Research & Clinical … (2025).4. Zhang, S. et al. Effect of hypoglycemic agents with weight loss effect plus a high protein diet and moderate exercise on diabetes remission in adults with obesity and type 2 diabetes: a …. BMC medicine (2025).5. Guo, C., Yang, W., Zhou, J. & Wang…, J. J. Ultra‐Processed Food Intake and Risk of Adverse Liver Outcomes: A Meta‐Analysis. Journal of Food … (2025).
¿Tu abdomen cambia de un día para otro y parece que has engordado en cuestión de horas?
En este episodio del Podcast de Nutrición de Fit Generation entrevistamos a la Dra. María Martínez Villaescusa (@dramvillaescusa), médico nefróloga y experta en microbiota femenina. En una charla completa y práctica donde hablamos de cómo la alimentación influye en la salud de la piel y el acné, la importancia de la microbiota, así como de la salud de los riñones, entre otros temas interesantes. ➡️ Instagram de la invitada (María): https://www.instagram.com/dramvillaescusa/?hl=es ¿Buscas una carrera universitaria enfocada en el fitness o la nutrición? Descubre las carreras oficiales de Fit Generation. Solo 3 años, actualizadas, con clases online y sin nota de corte. NHYD - Nutrición Humana y Dietética: https://bit.ly/47GaA8N CAFYD - Ciencias de la Actividad Física y el Deporte: https://bit.ly/45r1wTU ÍNDICE 00:00:00 A continuación… 00:01:10 Presentación de Dra. María Martínez Villaescusa 00:02:52 Qué alimentos ayudan a tener una piel más saludable 00:18:45 Cómo mejorar tu microbiota intestinal y su importancia 00:39:45 Alimentos que benefician la salud de los riñones 01:01:31 Conclusión y despedida del episodio
Join Dr Brad Leech and ambassador Lisa Costa-Bir on her inaugural podcast on all things gut inflammation. Brad breaks down the importance of functional testing for assessing inflammation, with a detailed discussion on interpreting the four major tests: calprotectin, lactoferrin, occult blood and secretory IgA. Learn about the importance of personalising treatment for patients with gut inflammation and how to effectively use (and dose) key anti-inflammatory herbs and nutrients for optimal efficacy. Clinical take-homes for use in your practice will also include dietary recommendations and an interesting discussion on colon cleansing. COVERED IN THIS EPISODE (00:50) Welcoming Dr Brad Leech (02:02) Intestinal inflammation vs intestinal permeability (03:29) Signs and symptoms of intestinal inflammation (06:43) Functional assessments for intestinal inflammation (23:41) How the microbiome influences intestinal inflammation (36:05) When should we test our patients? (42:07) Treatment options for combating intestinal inflammation (46:32) Which diets improve intestinal inflammation and why? (50:00) Colon cleansing: do or don't? (53:08) Thanking Brad and key takeaways Find today's transcript and show notes here: https://www.bioceuticals.com.au/education/podcasts/intestinal-inflammation-clinical-definition-testing-treatment Sign up for our monthly newsletter for the latest exclusive clinical tools, articles, and infographics: www.bioceuticals.com.au/signup/ DISCLAIMER: The information provided on fx Medicine by BioCeuticals is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.
In this encore episode, we detail the oral-gut microbiota axis, detailing the oral microbiome and its relationship with the intestinal microbiome. We discuss the development of oral biofilm, the transition from plaque to dental calculus, and potential impacts of oral dysbiosis, while highlighting intestinal health and focusing on Fusobacterium nucleatum. Topics:1. Overview of the Oral Microbiome and the Oral-Gut Axis - The oral cavity and the gut: microbially dense sites. - Anatomically distinct but connected and capable of influencing each other. - The oral microbiome. - Microbial distribution: topography and chemistry of oral surfaces. 2. Oral Cavity Anatomy and Microenvironments - The vestibule and oral cavity proper. - Lined by oral mucosa, which varies in structure. - Unique ecological niches that support different microbial populations. 3. Tooth Structure and Relevance to Microbial Colonization - Teeth are embedded in the alveolar processes of the maxilla and mandible. - Tooth structure. - Long-term microbial colonization and biofilm development. 4. Biofilm / Dental Plaque Development - Biofilm begins with the formation of the acquired pellicle.- Pioneer species secreting extracellular polymeric substances (EPS).- Secondary colonizers coaggregate.- Coaggregation is species-specific.- Example.- Aerobes can lower local oxygen levels, creating micro anaerobic niches that support obligate anaerobes. 5. Maturation of the Biofilm - Biofilm composition shifting to anaerobic, proteolytic species such as P. gingivalis. - F. nucleatum: a bridge species. 6. Mineralization and Formation of Dental Calculus - Mineralization, calcium and phosphate deposition. - Dental calculus. 7. Oral Dysbiosis - An imbalance in the oral microbial community. - Potential signs and symptoms. - Halitosis, swollen or bleeding gums, tooth sensitivity. 8. Oral-Gut Axis and Systemic Implications - Physical, chemical, biochemical, and immunological barriers aid in preventing oral bacteria from colonizing the gut. - Oral bacteria can potentially impact intestinal health. - F. nucleatum and IBD. 9. Oral Microbiome Testing10. Multi-Factorial Thank you to our episode sponsors: 1. OmneDiem®'s Histamine Digest® and Histamine Digest® PureMAX : Use code STXAL9VI for 15% off.2. Histamine Digest® Histamine Complete with DAO, Vitamin C, Quercetin, Bromelain, and Stinging Nettle Root Extract: Use code STXAL9VI for 15% off.3. Codex Labs: Explore Codex Labs' collections for acne, eczema, and more. Shop the BIA Collection HereGet Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessVisit synthesisofwellness.com
Hoy vamos a hablar de algo que, aunque suena muy técnico, tiene mucho que ver con lo que muchas personas sienten a diario: hinchazón, cansancio, niebla mental, intolerancias nuevas, brotes cutáneos, digestiones pesadas…Todo esto puede estar relacionado con un desequilibrio en la microbiota intestinal (lo que llamamos disbiosis) y con una alteración de la barrera intestinal (permeabilidad).Imaginemos el intestino como un muro de seguridad. Por un lado, está la microbiota: millones de bacterias que viven ahí y que cumplen funciones fundamentales. Por otro, una barrera que permite pasar lo que necesitamos y bloquea lo que no.Si ese muro se debilita —por estrés crónico, dieta pobre, tóxicos, medicación, infecciones, sedentarismo, etc.—, empieza a haber filtraciones: entran sustancias que no deberían entrar, se activa el sistema inmune, se produce inflamación… y aparecen síntomas.Esta condición no es una “moda” ni una invención. Tiene evidencia detrás. Se puede medir. Se puede tratar.¿Y cómo?Con una alimentación rica en fibra prebiótica (frutas, verduras, legumbres, tubérculos),Reducción de ultraprocesados y sustancias inflamatorias,Aporte adecuado de proteínas y grasas buenas,Suplementos como glutamina, zinc, vitamina D o probióticos específicos,Y trabajo integral: descanso, manejo del estrés y movimiento regular.La permeabilidad no se trata solo desde la comida. Es un enfoque global. Y sobre todo, no se trata sin diagnóstico ni personalización.Así que si te sientes inflamado, sensible a todo, con digestiones extrañas y fatiga persistente… no lo ignores. El intestino puede estar intentando decirte algo.Conviértete en un seguidor de este podcast: https://www.spreaker.com/podcast/comiendo-con-maria-nutricion--2497272/support.
A saúde digestiva é a base para o bem-estar geral, e os probióticos são uma das ferramentas mais poderosas para restaurar o equilíbrio intestinal. Neste segundo episódio da nossa série, o Dr. Dan Waitzberg e a Dra. Barbara Peters focam na aplicação clínica dos probióticos.Descubra como cepas específicas podem ser aliadas no manejo da Síndrome do Intestino Irritável (SII), na prevenção da diarreia associada a antibióticos e o que as principais diretrizes médicas dizem sobre o assunto. Uma discussão prática e baseada em evidências para o seu dia a dia no consultório.ReferênciasFord AC, Quigley EM, Lacy BE, et al. Efficacy of probiotics in irritable bowel syndrome: systematic review and meta-analysis. Gut. 2014;63(3):431-42.McFarland LV. Meta-analysis of probiotics for prevention of antibiotic-associated diarrhea. Am J Gastroenterol. 2006;101(4):812–822.Derikx LAAP, Dieleman LAM. Probiotics in inflammatory bowel disease. Best Pract Res Clin Gastroenterol. 2015;29(1):219–227.Madsen KL. Probiotic bacteria and intestinal epithelial barrier function. Am J Physiol Gastrointest Liver Physiol. 2001;280(5):G947–G956.Rios-Covián D, et al. Intestinal short-chain fatty acids and their link with diet and human health. Front Microbiol. 2016;7:185.Lebeer S, Vanderleyden J, De Keersmaecker SC. Host interactions of probiotic bacterial surface molecules. Nat Rev Microbiol. 2010;8(3):171–184.Lozupone CA, et al. Diversity, stability and resilience of the human gut microbiota. Nature. 2012;486(7402):207–214.Bastelica D, et al. Role of gut microbiota in the production of vitamin K and B vitamins. Nutrients. 2017;9(7):E.娱乐城
Today I'm excited to have board-certified internist and complex chronic disease expert, Dr. Tania Dempsey back on the podcast to discuss parasites. Hidden parasites are more common than you think and may even be related to conditions such as SIBO, IBS, Histamine intolerance and poor immune system health. We'll cover the types of parasites, best testing options, a treatment protocol and how to prevent parasites. You don't want to miss this! Start healing with us! Learn more about our virtual clinic: https://drruscio.com/virtual-clinic/ Follow Dr. Tania Dempsey https://drtaniadempsey.com/about/ https://drtaniadempsey.com/podcast/ https://www.instagram.com/drtaniadempseymd/ https://www.youtube.com/@DrTaniaDempsey https://www.facebook.com/taniadempseymd/
In this episode, we detail the structure and function of the intestinal mucosal barrier, highlighting key roles that zinc plays in supporting various aspects of mucosal barrier integrity. We detail key anatomical features, including the mucus layer, epithelial cells, and tight junctions, before discussing zinc's physiological roles, its relationship with copper, and factors that can affect zinc levels. The discussion further details mechanistic features of zinc absorption as well as specialized forms such as zinc carnosine.Topics:1. Introduction - Overview of intestinal hyperpermeability and intestinal barrier function- Highlighting the role of zinc 2. Intestinal Barrier Anatomy - Four major layers: mucosa, submucosa, muscularis externa, serosa- Mucosa subdivisions; focus on epithelium 3. The Mucus Layer - Location over the epithelial surface- Composition: mucin-rich, secreted by goblet cells- Goblet cell mucin storage and expansion upon hydration- Functions: trapping pathogens, lubricating epithelium, housing molecules including secretory IgA- Small intestine mucus - Large intestine mucus 4. The Intestinal Epithelium - Monolayer of epithelial cells: enterocytes, goblet cells, and more- Tight junctions, paracellular transport - Continuous epithelial renewal 5. Introduction to Zinc - Zinc as a trace mineral required in minute quantities for numerous physiological processes - Second most abundant trace mineral after iron; majority stored in muscle and bone- Maintaining plasma and intracellular zinc concentrations within narrow range- Both deficiency and excess can disrupt biochemical processes 6. Zinc and Copper - Zinc and copper as closely interconnected minerals- Zinc, copper, and metallothionein binding in enterocytes- Both high and low zinc can disrupt zinc-copper balance- Metallothionein as a cysteine-rich metal-binding protein 7. Factors Affecting Zinc Levels - Multifactorial- Possible signs of low zinc status 8. Zinc Absorption - Dietary sources- Primary absorption in small intestine - In the stomach: HCl and pepsin denature proteins and cleave peptide bonds, releasing zinc from protein complexes- Dietary zinc often bound within tertiary protein structure- Specialized transporters 9. Zinc's Role in the Intestinal Barrier - Zinc and tight junction proteins- Zinc and Intestinal Epithelial Cells - Zinc and the mucus layer 10. Broader Context of Zinc in Physiology 11. Zinc Carnosine - Molecular complex of zinc and carnosine- L-carnosine composed of beta-alanine and L-histidine- Gastrointestinal context 12. Conclusion - Multifactorial and multi-system.Thank you to our episode sponsors: 1. OmneDiem®'s Histamine Digest® and Histamine Digest® PureMAX : Use code STXAL9VI for 15% off.2. Histamine Digest® Histamine Complete with DAO, Vitamin C, Quercetin, Bromelain, and Stinging Nettle Root Extract: Use code STXAL9VI for 15% off.3. Codex Labs: Explore Codex Labs' collections for acne, eczema, and more. Shop the BIA Collection HereThanks for tuning in!Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessVisit synthesisofwellness.com
Neste episódio, Jader Ricco, médico cirurgião e conteudista do Portal Afya, aborda as doenças inflamatórias intestinais (DII). O especialista ainda comenta os critérios de gravidade, as indicações de cirurgia na retocolite ulcerativa e na doença de Crohn e mais. Ouça agora!
Neste episódio, Jôbert Neves, médico gastroenterologista pediátrico e editor do Portal Afya, comenta a cobertura completa do ESPGHAN 2025. O especialista aborda os principais avanços em pediatria apresentados no congresso, com foco em Doença Inflamatória Intestinal, autismo, alergias alimentares, esofagite eosinofílica, hepatologia e os impactos dos ultraprocessados na saúde infantil. Um panorama conciso e atualizado do que há de mais relevante na gastroenterologia e nutrição pediátrica.
In this encore episode, we detail the gut-immune axis, focusing on the protective mucus layer and the roles of secretory immunoglobulin A and lactoferrin in intestinal health. We discuss endogenous secretions as well as highlight lactoferrin testing and levels. Topics: 1. The Intestinal Barrier & Mucus Layer- The intestinal lumen, microbiome, mucus layer, epithelial cells, and lamina propria.- The mucus layer: antimicrobial peptides (AMPs) and secretory IgA (sIgA).- Intestinal epithelial cells including goblet cells and enterocytes.2. Immune Cells in the Gut- The lamina propria.- Macrophages, dendritic cells, neutrophils, B cells, T cells, mast cells, and more.3. Antimicrobial Peptides & Secretory IgA- AMPs and sIgA in the mucus layer aid in regulating microbial balance and pathogen adhesion.4. Lactoferrin: Functions & Sources- Iron-binding glycoprotein, antimicrobial and immunomodulatory properties.- Found in mucosal secretions, colostrum, and more.- Intestinal epithelial cells (IECs) and neutrophils.5. Lactoferrin's Role in Intestinal Health- Regulates iron absorption via lactoferrin receptors (LFR)on enterocytes.- Sequesters free iron, limiting bacterial growth, bacteriostatic.- Destabilizes bacterial membranes, cell lysis, bactericidal.6. Lactoferrin Levels- Neutrophils release lactoferrin during infection,increasing its presence in the large intestine.- Fecal lactoferrin levels.- Fecal calprotectin levels.7. Candida Overgrowth8. Lactoferrin Supplementation to Support the Gut9. Conclusion- The intestinal mucus layer.- Lactoferrin.Thank you to our episode sponsor: 1. OmneDiem®'s Histamine Digest® and Histamine Digest® PureMAX 2. Histamine Digest® Histamine Complete with DAO, Vitamin C, Quercetin, Bromelain, and Stinging Nettle Root Extract.Thanks for tuning in!Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessVisit synthesisofwellness.com
Neste episódio, Julia Vargas, médica intensivista e conteudista do Portal Afya, aborda a obstrução intestinal, uma patologia comum nas emergências. A especialista ainda fala sobre como suspeitar, diagnosticar e tratar a doença. Ouça agora dando o play!Confira esse e outros posts no Portal Afya e siga nossas redes sociais!FacebookInstagramLinkedinTwitter
No episódio de hoje do Check-up Semanal, confira as últimas notícias sobre: depressão psicótica; hiperaldo e doença cardiovascular; hipertensão crônica na gestação; ablação radiofrequência de nódulos tireoidianos e constipação intestinal em crianças. Escute agora mesmo!Confira esse e outros posts no Portal Afya e siga nossas redes sociais!FacebookInstagramLinkedinTwitter
Jaume Segalés y los responsables de Mundo Natural hablan de salud y del intestino poroso (permeabilidad intestinal)
In this encore episode, we detail overlap among intestinal methanogen overgrowth (IMO), hydrogen-dominant small intestinal bacterial overgrowth (H₂-SIBO), and hydrogen sulfide-dominant SIBO (H₂S-SIBO), discussing their mechanistic interactions. We discuss methanogenic archaea, as well hydrogen sulfide- and hydrogen-producing microbes and their contributions to altered gastrointestinal motility, epithelial barrier function, and neuromuscular signaling. We detail host endogenous defense mechanisms, including gastric acid secretion, pancreatic enzymatic activity, bile flow, intestinal motility, and more.Topics:1. Introduction- Overview of intestinal methanogen overgrowth (IMO), hydrogen sulfide-dominant SIBO, and hydrogen-dominant SIBO - Discussion of overlap 2. Intestinal Methanogen Overgrowth (IMO)- Characterized by an overabundance of methane-producing archaea - Methane and intestinal transit- Bloating, abdominal discomfort, constipation - Associated with irritable bowel syndrome with constipation (IBS-C) 3. Overlap Between IMO and SIBO Subtypes- Hydrogen as a substrate for methane and/or hydrogen sulfide production- Shared potential root causes 4. Small Intestinal Bacterial Overgrowth (SIBO) and Protective Mechanisms- The small intestine remains relatively free of bacteria due to protective mechanisms - Gastric acid secretion - Pancreatic enzymes and bile - Intestinal motility- Structural abnormalities 5. Hydrogen-Dominant SIBO - Increased hydrogen and intestinal transit- Potential symptoms, diarrhea, postprandial bloating - Different forms of SIBO can coexist 6. Hydrogen Sulfide-Dominant SIBO - H₂S and intestinal motility- H₂S and intestinal epithelial integrity- Symptoms, associations with IBS diarrhea 7. Host Defense Mechanisms Regulating Microbial Balance- Gastric acid secretion, pancreatic enzyme activity, bile flow, intestinal motility, and more 8. Gastric Acid and Its Role in Microbial Regulation- Parietal cells secrete hydrochloric acid (HCl) and intrinsic factor - Chief cells secrete pepsinogen, conversion into pepsin in acidic conditions - Gastric acid, digestion and antimicrobial defense 9. Hypochlorhydria - Low gastric acid impairs microbial defense- Reduced acidity disrupts digestion and downstream pancreatic enzyme and bile release 10. Pancreatic Enzymes and Their Role in Microbial Regulation- Pancreatic enzymes, digestion, antimicrobial activity - Enzymes modify chyme to limit fermentable substrates that fuel microbial proliferation 11. Intestinal Motility - Coordinated contractions propel food, microbes, and waste through the GI tract - The enteric nervous system (ENS) and gut motility- The myenteric plexus controls peristalsis, while the submucosal plexus regulates secretion and absorption 12. Conclusion- Intestinal methanogen overgrowth (IMO), hydrogen-dominant SIBO, and hydrogen sulfide-dominant SIBO - Overlap in symptoms and microbial interactions - Host defense mechanisms, including gastric acid, pancreatic enzymes, and motility - Intestinal motility and ENS function in microbial homeostasis - Hydrogen sulfide as a gasotransmitterGet Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessVisit synthesisofwellness.com
Le cerveau de l'intestin joue un rôle prédominant dans votre bien-être. Emilie Steinbach vous explique comment favoriser sa diversité et sa richesse pour un meilleur confort digestif.Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.
Jaume Segalés y los responsables de Mundo Natural hablan de salud y de la flora intestinal.
¿Estreñimiento, gases o fatiga? Haz una limpieza intestinal profunda con enzimas y flora buena. ¡Desintoxica, mejora tu digestión y renueva tu salud!
Food doesn't cause IBS. But the fear around food? That's real. In this episode of The Gut Show, I'm talking about when restrictions help, when they don't, and what else could be driving your symptoms. Thank you to our partners: @GemelliBiotech offers trusted, science-backed at-home tests for conditions like SIBO, IMO, ISO, and post-infectious IBS. Their Trio-Smart breath test measures all three key gases: hydrogen, methane, and hydrogen sulfide to detect different forms of microbial overgrowth. And for those with IBS symptoms, IBS-Smart is a simple blood test that can confirm post-infectious IBS with clinical accuracy. You simply order the test, complete it at home, send it back, and get clinically backed results in about a week that you can take to your provider! Find out which tests are right for you at getgutanswers.com and use code ERINJUDGE25 to save $25 on your order! @FODZYME is the world's first enzyme supplement specialized to target FODMAPs. When sprinkled on or mixed with high-FODMAP meals, FODZYME's novel patent-pending enzyme blend breaks down fructan, GOS and lactose before they can trigger bloating, gas and other digestive issues. With FODZYME, enjoy garlic, onion, wheat, Brussels sprouts, beans, dairy and more — worry free! Discover the power of FODZYME's digestive enzyme blend and eat the foods you love and miss. Visit fodzyme.com and save 20% off your first order with code THEGUTSHOW. One use per customer. This episode is made possible with support from Ardelyx. Covered in this episode: Why I work with IBS [3:10] The most common reason for dietary restriction in IBS [4:09] Food intolerance in IBS [6:10] Visceral hypersensitivity [7:45] Immune activation [9:05] Dysbiosis [9:54] Intestinal permeability [10:51] Food does not cause IBS [12:42] (social?) When do restrictions work? [14:01] When restrictions work against you [16:47] Pitfalls to be aware of [23:06] Support for food fear [36:59] How to approach dietary restrictions [45:59] Sustainable ways to approach restrictions [47:27] Non food restriction strategies [51:23] What does managing IBS look like? [52:15] How do you get there? [56:20] Mentioned in this episode: MASTER Method Membership Take the quiz: What's your poop personality? Malabsorption Overlapping With or Masking as IBS Connect with Gutivate: IG: https://www.instagram.com/erinjudge.rd TikTok: https://www.tiktok.com/@erinjudge.rd Work with Gutivate: https://gutivate.com/services
The gang buys some stuff. Asim does some praying. Pan saves a life. Finn gives a hug. Mairwyn, well, she's not doing so great. Hopefully it doesn't cost much to replumb the inn.Join our Patreon!https://patreon.com/unstabletopThe rest of our links can be found at:https://unstabletop.net
In this episode, we detail Small Intestinal Fungal Overgrowth (SIFO), with a focus on fungal biofilm formation and its role in promoting microbial persistence and evasion of host immune responses. We discuss the phenotypic plasticity of Candida species, as well as biofilm matrices adherent to the intestinal mucosa. We further highlight common symptoms of SIFO as well as the effects of hypochlorhydria, reduced pancreatic enzyme and bile output, impaired motility, diminished commensal bacterial populations, and weakened mucosal immunity.Topics: 1. Introduction- Focus on the gut mucosal barrier.- Emphasis on Small Intestinal Fungal Overgrowth (SIFO) and biofilms.2. Intestinal Barrier Anatomy- The mucosa: epithelium, lamina propria, and a thin band of smooth muscle.- The epithelial layer.- Covered by protective mucus composed of mucin glycoproteins secreted by goblet cells.- In the small intestine: less dense mucus.3. Epithelial Integrity- Tight junctions.- Paracellular barrier preventing uncontrolled antigen passage.4. Lamina Propria5. Overview of Small Intestinal Fungal Overgrowth (SIFO)- SIFO involves fungal overgrowth in the small intestine, commonly Candida species.- Small intestines: Low microbial density due to motility, gastric acid, bile acids, immune surveillance, and more.- Contributing factors: hypochlorhydria, impaired motility, reduced digestive enzymes, diminished competitive flora, lowered immunity, and more.6. Candida Pathogenicity- Candida exhibits phenotypic plasticity: yeast and hyphal forms.- Biofilm formation.7. Biofilm Formation- Biofilms are structured communities of microbes within a self-produced extracellular matrix.- Resistance to antimicrobials and immune defenses.- Can develop on intestinal mucosa and in various other regions.8. SIFO and SIBO Overlap- Root causes and overlap between SIFO and Small Intestinal Bacterial Overgrowth (SIBO).- Common symptoms.9. Gastric Acid in More Detail- Stomach epithelium includes mucous, parietal, chief, and enteroendocrine cells- Parietal cells secrete hydrochloric acid.- HCl denatures proteins and aids in inhibiting pathogens.- Hypochlorhydria: possible causes. 10. Downstream Effects of Low Acid11. Gut Motility in More Detail- Motility involves rhythmic smooth muscle contractions.- Enteric nervous system (ENS): myenteric and submucosal plexuses.- Dysautonomia and motility.12. SIFO Contributing Factors13. Candida Regulation- Candida generally remains in unicellular yeast form under homeostatic regulation.- Controlled by microbial competition, host defenses, antifungal peptides, and more.14. Role of Mucus and sIgA- Mucosal immunity (including sIgA) aids in regulating Candida populations.- Low sIgA levels (due to stress, immune suppression, dysbiosis,…) weaken defense 15. Conclusion- Mucosal barrier structure.- SIFO and Candida.- Biofilm formation, microbial persistence, and mucosal disruption.- SIFO and SIBO.- Multifactorial nature of fungal dysbiosis, types of biofilms, and small intestinal overgrowth.Thank you to our episode sponsor: 1. OmneDiem®'s Histamine Digest® and Histamine Digest® PureMAX 2. Histamine Digest® Histamine Complete with DAO, Vitamin C, Quercetin, Bromelain, and Stinging Nettle Root Extract.Thanks for tuning in!Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessFollow Chloe on TikTok @chloe_c_porterVisit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more!
In this encore episode, we highlight vitamin D₃ in gastrointestinal health, with a focus on intestinal barrier function and the gut-immune axis. We discuss how vitamin D is metabolized into its active form, 1,25-dihydroxyvitamin D, and how 1,25-dihydroxyvitamin D can support the intestinal mucosa, while highlighting the intestinal epithelium and immune cells in the lamina propria. Through this, we further detail the role of regulatory T cells in supporting immune balance and modulating immune function.Topics:1. Introduction - Highlighting intestinal barrier function and the gut-immune axis with a focus on vitamin D₃ 2. Vitamin D Synthesis and Metabolism - Skin and 7-dehydrocholesterol; dietary intake.- Transported through the bloodstream bound to vitamin D binding protein.- First hydroxylation in the liver to form 25-hydroxyvitamin D₃ (25(OH)D₃).- Testing.- Second hydroxylation in the kidney to form the active 1,25 dihydroxyvitamin D₃ (1,25(OH)₂D₃).- Local activation also occurs. 3. Intestinal Barrier Anatomy - The intestinal epithelium forms a selectively permeable monolayer that interfaces with the gut lumen.- Covered by a mucus layer: mucins, antimicrobial peptides, secretory IgA.- Mucus layer provides physical and biochemical protection.- Tight junction proteins and paracellular permeability.- Molecules crossing the epithelium. - Disruption of tight junctions, immune cell exposure to luminal contents.- The lamina propria and Gut-Associated Lymphoid Tissue (GALT). - Maintaining tolerance while defending against pathogens. 4. Vitamin D's Role in Barrier Support and Immune Modulation - 1,25-dihydroxyvitamin D₃, tight junction integrity, immune regulation, and more.- Regulatory T Cells (Tregs) and immune balance. 5. Vitamin D₂ and D₃- D₃ (cholecalciferol) is more biologically effective and binds DBP more strongly. 6. Vitamin D Levels - Levels observed in autoimmune conditions, IBS, and more.- Symptoms.- Insufficient and excessive levels of vitamin D can be detrimental.- Multi-system. 7. Conclusion - Multifactorial: Numerous factors regulate vitamin D levels.- Gastrointestinal health root cause approach.Thanks for tuning in!Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessFollow Chloe on TikTok @chloe_c_porterVisit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more!
Jaume Segalés y los responsables de Mundo Natural hablan de salud y de la microbiota o flora intestinal sana.
In this podcast, JPEN Editor-in-Chief Dr. Kenneth Christopher, interviews Niklas Tappauf PhD Candidate in Experimental Medicine at The University of British Columbia. Niklas Tappauf's research is on pediatric health and biomarker development with a specific focus on the microbiome. Niklas Tappauf is first author of the research article “Multiomics profiling and parenteral nutrition weaning in pediatric patients with intestinal failure: A longitudinal cohort study”. Business Corporate by Alex Menco | alexmenco.net Music promoted by www.free-stock-music.com Creative Commons Attribution 3.0 Unported License creativecommons.org/licenses/by/3.0/deed.en_US May 2025
Dr. Mahima Swamy is a Program Leader at the University of Dundee, where her lab studies immune homeostasis in the intestinal epithelium. She talks about intestinal intraepithelial lymphocytes and the role of LRRK2 in Parkinson's and Crohn's disease.
Inician pruebas preoperativas del corredor de transporte público Tenango-Metepec-TolucaTrump "no tolerará" que siga juicio contra NetanyahuMás información en nuestro Podcast
Le microbiote intestinal et les maladies cardiaques Quel est le rôle du microbiote intestinal dans la survenue de maladies cardiaques? Des cardiologues de l'Hôpital de l'Île à Berne explorent le lien entre le microbiote intestinal et les maladies cardiaques, notamment la sténose aortique calcifiée. Elles et ils étudient comment les bactéries intestinales influencent la calcification des valves cardiaques, ouvrant la voie à de nouvelles approches thérapeutiques. Votre père est-il vraiment votre père biologique? Plusieurs études suggèrent que, dans la société occidentale, le taux dʹenfants qui ne sont pas ceux de leur père "officiel" tourne autour des 1-2%, soit bien moins que les chiffres qui ont pu être articulés par le passé. Et ceci, depuis des siècles. Dans dʹautres cultures, en revanche, où la paternité est considérée différemment, le taux peut approcher les 50%. La petite histoire des nombres du secrétaire perpétuel de lʹacadémie française des sciences Stéphane Délétroz reçoit Etienne Ghys, mathématicien et secrétaire perpétuel de l'académie française des sciences. Après celles des flocons de neige et du ballon de foot, Etienne Ghys nous raconte "Ma petite histoire des nombres". Un livre, publié chez Odile Jacob, destiné aussi bien aux nuls en math qu'aux forts en thèmes.
Un travail de maturité vaudois sur l'antibiorésistance récompensé Les brèves du jour Le microbiote intestinal et les maladies cardiaques Ces phénomènes mystérieux résolus par la science La petite histoire des nombres du secrétaire perpétuel de l'académie française des sciences
A live de hoje foi um sucesso. Abordei uma dúvida que gera muita polêmica: afinal, a carne piora a inflamação intestinal?Mostrei o que a ciência realmente diz sobre o consumo de carne em pessoas com Doença Inflamatória Intestinal, desmascarando mitos e revelando evidências que muita gente prefere ignorar.No final, ainda respondi perguntas e compartilhei dicas valiosas para quem quer recuperar a saúde com comida de verdade.Este conteúdo não é uma recomendação médica ou nutricional.O acompanhamento profissional é fundamental.:::::: Seja Membro e Receba Aulas e Conteúdos Exclusivos :::::https://www.youtube.com/channel/UCgeSWvdpxC7Ckc77h_xgmtg/join::::: ONDE COMPRAR O LIVRO UMA DIETA ALÉM DA MODA :::::::Versão capa comum: https://amzn.to/4iWn27lVersão para Kindle: https://amzn.to/4jkHoXM::::: ONDE COMPRAR O LIVRO O CÓDIGO DA OBESIDADE :::::::Versão capa comum: https://amzn.to/4hlGEQBVersão para Kindle: https://amzn.to/4ikh6Vh::::: ONDE COMPRAR O LIVRO GORDURA SEM MEDO :::::::Versão capa Dura: https://amzn.to/4hH5wTUVersão para Kindle: https://amzn.to/4158Y3r:::: GLICOSÍMETROhttps://amzn.to/3Zy5AhZ:::: GRUPO VIP NO WHATSAPP ::::https://chat.whatsapp.com/L9Los9HHdmP5Pf09O4i7HKEntre em meu Canal do Telegram:https://t.me/canalandreburgosInscreva-se em nosso canalhttp://goo.gl/Ot3z2rSaiba mais sobre o Programa Protagonista em: https://escoladoprotagonista.com.br/ofertaPrograma Atletas LowCarb:https://atletaslowcarb.com.br/programa-alc/Me siga no Instagramhttps://www.instagram.com/andreburgos/
Jaume Segalés y los responsables de Mundo Natural hablan de salud y de la permeabilidad intestinal aumentada.
Chaz and AJ started the show this morning with news from North Haven, where SWAT had been summoned and no one knew the full story. Things only got stranger, when it seemed no one from the town was calling in. (0:00) Claude Strother was on with Chaz and AJ a few months ago after surviving a Bobcat attack, and then had to deal with a cancer diagnosis. After a Tribe member called asking for an update, he was on this morning to share some good news, and a story from his town's "Intestinal and Testicle Festival." (11:55) Howard Saffan, owner and president of the Hartford HealthCare Amphitheater was on the phone this morning to look forward to a busy summer season at the amp. (25:36) Judge Lisa Wexler was in studio this morning, to share her thoughts on the Karen Read trial and some examples of crazy wills she's seen come through the court. (36:14)
In this encore episode, we detail the gut-immune axis, focusing on the protective mucus layer and the role of lactoferrin in intestinal health. We discuss endogenous secretions and how lactoferrin functions as an antimicrobial, immunomodulatory, and iron-regulating glycoprotein, influencing microbial balance and intestinal barrier integrity. Additionally, we highlight lactoferrin testing and levels. We finish by going through supplementation as a phenomenal tool.Topics: 1. The Intestinal Barrier & Mucus Layer- The intestinal lumen, microbiome, mucus layer, epithelial cells, and lamina propria.- The mucus layer: antimicrobial peptides (AMPs) and secretory IgA (sIgA).- Intestinal epithelial cells including goblet cells and enterocytes.2. Immune Cells in the Gut- The lamina propria.- Macrophages, dendritic cells, neutrophils, B cells, T cells, mast cells, and more.3. Antimicrobial Peptides & Secretory IgA- AMPs and sIgA in the mucus layer regulate microbial balance and prevent pathogen adhesion.4. Lactoferrin: Functions & Sources- Iron-binding glycoprotein, antimicrobial and immunomodulatory properties.- Found in mucosal secretions, colostrum, and more.- Intestinal epithelial cells (IECs) and neutrophils.5. Lactoferrin's Role in Intestinal Health- Regulates iron absorption via lactoferrin receptors (LFR)on enterocytes.- Sequesters free iron, limiting bacterial growth, bacteriostatic.- Destabilizes bacterial membranes, cell lysis, bactericidal.6. Lactoferrin Levels- Neutrophils release lactoferrin during infection,increasing its presence in the large intestine.- Fecal lactoferrin levels.- Fecal calprotectin levels.7. Lactoferrin & Candida Overgrowth- Fungal membranes.- Aiding in the inhibition of biofilm formation.8. Lactoferrin Supplementation & Benefits- Supports gut microbiota, epithelial integrity, and immune modulation.- Bovine colostrum and as a supplement.9. Conclusion- The intestinal mucus layer is key to gut barrier function.- Lactoferrin plays a central role in microbial regulation and immune defense.Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessVisit synthesisofwellness.com
What is intestinal ultrasound? How can it change the way we take care of our patients with inflammatory bowel disease? Dr. Bincy Abraham, Professor of Clinical Medicine at Houston Methodist and Director of the Fondren Inflammatory Bowel Disease Program, answers these questions and more in this episode of the Gut Doctor Podcast.
Send us a text¿Sabías que la salud digestiva es clave para un óptimo rendimiento físico y mental? En este episodio, Fer Alvarado, platica con Ivonne Vargas, especialista en nutrición deportiva, sobre la fascinante relación entre la microbiota intestinal y el rendimiento deportivo. Descubre cómo evitar los problemas digestivos más comunes, aprende sobre estrategias integrales para mejorar tu salud digestiva y alcanzar tu máximo potencial. INVITADA: Ivonne Vargas es licenciada en nutrición y tiene una maestría en alto rendimiento deportivo y entrenamiento. También cuenta con estudios en neurociencias aplicadas al ejercicio. Ha trabajado con el equipo de triatlón del Real Madrid y el equipo paralímpico en Río 2016.
#ElGranMusical | Karen Alarcón, Probióticos y sus beneficios para la salud intestinal by FM Mundo 98.1
In this encore episode, we detail the intestinal mycobiome and the mechanisms by which beneficial microbes aid in regulating opportunistic fungal species: Candida albicans. We discuss Candida overgrowth virulence and how disruptions in microbial balance, immune function, and epithelial integrity impact Candida's pathogenicity. Additionally, we discuss the role of mast cells in the lamina propria, their involvement in mucosal immunity, and how Mast Cell Activation Syndrome (MCAS) can be exacerbated by fungal dysbiosis / microbial imbalances.Topics: 1. Introduction - The intestinal mycobiome and its role in intestinal health. - Regulating populations of opportunistic fungal species like Candida albicans.- Mast cell activation syndrome (MCAS) intro. 2. Structure of the Intestinal Barrier- The microbiome and mucus layer: microbes, mucins, antimicrobial peptides, sIgA.- The epithelial monolayer: enterocytes, goblet cells, Paneth cells, enteroendocrine cells…- Tight junction proteins and paracellular transport.- The lamina propria beneath the epithelium: immune cells and more. 3. Candida's Pathogenicity and Barrier Disruption- Exists primarily in its yeast form, regulated by microbial competition, host immune defenses, antifungal peptides. - Secretory IgA (sIgA) and immune surveillance mechanisms help regulate fungal populations. - Chronic stress, immune suppression, and dysbiosis can deplete sIgA, increasing susceptibility to Candida proliferation. - Environmental triggers such as immune suppression, microbial depletion, inflammatory cytokines.- Yeast-to-hyphal transition, deeper tissue invasion. - Secreted aspartyl proteinases (SAPs), phospholipases, candidalysin: epithelial damage.- Pattern recognition receptors (PRRs) and overgrowth detection. 4. Impact of Beneficial Bacteria on Candida Overgrowth - Beneficial bacteria compete with Candida for nutrients and epithelial adhesion sites. - Short-chain fatty acids (SCFAs) produced by beneficial bacteria.- Depletion of beneficial bacteria removes ecological resistance, allowing Candida to proliferate unchecked. 5. Mast Cells in the Lamina Propria and Their Role in Intestinal Immunity- Mast cell location - Upon activation, mast cells release histamine, cytokines, proteases, and more that regulate gut immune responses. - Histamine can increase gut permeability and modulate local immune activation. - Tryptase and chymase. - Pro-inflammatory cytokines. 6. Mast Cell Activation Syndrome (MCAS) - Mast cell hyperactivation.- Environmental triggers, toxins, chronic infections, and stress. - Candida overgrowth and mast cell activation.- Addressing microbial imbalances and reducing the body's total microbial, chemical, and toxin burden.- A diverse microbiome. 7. Conclusion- Candida overgrowth and regulation via immune defenses and beneficial bacterial competition.- MCAS, root cause approach.Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessVisit synthesisofwellness.com
En esta entrevista para MVS Noticias con Luis Cárdenas, la Doctora Francisca Martínez Silva, gastroenteróloga del Hospital Centro Médico Nacional La Raza del IMSS, habló sobre la enfermedad inflamatoria intestinal, un trastorno crónico, complejo y fluctuante que alterna brotes y remisiones.See omnystudio.com/listener for privacy information.
Vamos hablar del daño que provocan los colorantes artificiales al intestino y al cuerpo, porque recientemente la Administración de Alimentos y Medicamentos (FDA) declaró que los van a prohibir por los daños que provocan a la salud que van desde cáncer hasta déficit de atención. Hosted on Acast. See acast.com/privacy for more information.
In this encore episode, we detail the pathophysiology of intestinal methanogen overgrowth (IMO), hydrogen-dominant small intestinal bacterial overgrowth (H₂-SIBO), and hydrogen sulfide-dominant SIBO (H₂S-SIBO), discussing their mechanistic interactions and overlap. We discuss methanogenic archaea, as well hydrogen sulfide- and hydrogen-producing microbes and their contributions to altered gastrointestinal motility, epithelial barrier function, and neuromuscular signaling. We detail host endogenous defense mechanisms, including gastric acid secretion, pancreatic enzymatic activity, bile flow, intestinal motility, and more.Topics:1. Introduction- Overview of intestinal methanogen overgrowth (IMO), hydrogen sulfide-dominant SIBO, and hydrogen-dominant SIBO - Discussion of overlap 2. Intestinal Methanogen Overgrowth (IMO)- Characterized by an overabundance of methane-producing archaea - Methane and intestinal transit- Bloating, abdominal discomfort, constipation - Associated with irritable bowel syndrome with constipation (IBS-C) 3. Overlap Between IMO and SIBO Subtypes- Hydrogen as a substrate for methane and/or hydrogen sulfide production- Shared potential root causes 4. Small Intestinal Bacterial Overgrowth (SIBO) and Protective Mechanisms- The small intestine remains relatively free of bacteria due to protective mechanisms - Gastric acid secretion - Pancreatic enzymes and bile - Intestinal motility- Structural abnormalities 5. Hydrogen-Dominant SIBO - Increased hydrogen and intestinal transit- Potential symptoms, diarrhea, postprandial bloating - Different forms of SIBO can coexist 6. Hydrogen Sulfide-Dominant SIBO - H₂S and intestinal motility- H₂S and intestinal epithelial integrity- Symptoms, associations with IBS diarrhea 7. Host Defense Mechanisms Regulating Microbial Balance- Gastric acid secretion, pancreatic enzyme activity, bile flow, intestinal motility, and more 8. Gastric Acid and Its Role in Microbial Regulation- Parietal cells secrete hydrochloric acid (HCl) and intrinsic factor - Chief cells secrete pepsinogen, conversion into pepsin in acidic conditions - Gastric acid, digestion and antimicrobial defense 9. Hypochlorhydria - Low gastric acid impairs microbial defense- Reduced acidity disrupts digestion and downstream pancreatic enzyme and bile release 10. Pancreatic Enzymes and Their Role in Microbial Regulation- Pancreatic enzymes, digestion, antimicrobial activity - Enzymes modify chyme to limit fermentable substrates that fuel microbial proliferation 11. Intestinal Motility - Coordinated contractions propel food, microbes, and waste through the GI tract - The enteric nervous system (ENS) and gut motility- The myenteric plexus controls peristalsis, while the submucosal plexus regulates secretion and absorption 12. Conclusion- Intestinal methanogen overgrowth (IMO), hydrogen-dominant SIBO, and hydrogen sulfide-dominant SIBO - Overlap in symptoms and microbial interactions - Host defense mechanisms, including gastric acid, pancreatic enzymes, and motility - Intestinal motility and ENS function in microbial homeostasis - Hydrogen sulfide as a gasotransmitterGet Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessVisit synthesisofwellness.com
In this episode, we highlight vitamin D₃ in gastrointestinal health, with a focus on intestinal barrier function and the gut-immune axis. We discuss how vitamin D is metabolized into its active form, 1,25-dihydroxyvitamin D, and how 1,25-dihydroxyvitamin D can support the intestinal mucosa, while highlighting the intestinal epithelium and immune cells in the lamina propria. Through this, we further detail the role of regulatory T cells in supporting immune balance and modulating immune function.Topics:1. Introduction - Highlighting intestinal barrier function and the gut-immune axis with a focus on vitamin D₃ 2. Vitamin D Synthesis and Metabolism - Skin and 7-dehydrocholesterol; dietary intake.- Transported through the bloodstream bound to vitamin D binding protein.- First hydroxylation in the liver to form 25-hydroxyvitamin D₃ (25(OH)D₃).- Testing.- Second hydroxylation in the kidney to form the active 1,25 dihydroxyvitamin D₃ (1,25(OH)₂D₃).- Local activation also occurs. 3. Intestinal Barrier Anatomy - The intestinal epithelium forms a selectively permeable monolayer that interfaces with the gut lumen.- Covered by a mucus layer: mucins, antimicrobial peptides, secretory IgA.- Mucus layer provides physical and biochemical protection.- Tight junction proteins and paracellular permeability.- Molecules crossing the epithelium. - Disruption of tight junctions, immune cell exposure to luminal contents.- The lamina propria and Gut-Associated Lymphoid Tissue (GALT). - Maintaining tolerance while defending against pathogens. 4. Vitamin D's Role in Barrier Support and Immune Modulation - 1,25-dihydroxyvitamin D₃, tight junction integrity, immune regulation, and more.- Regulatory T Cells (Tregs) and immune balance. 5. Vitamin D₂ and D₃- D₃ (cholecalciferol) is more biologically effective and binds DBP more strongly. 6. Vitamin D Levels - Levels observed in autoimmune conditions, IBS, and more.- Symptoms.- Insufficient and excessive levels of vitamin D can be detrimental.- Multi-system. 7. Conclusion - Multifactorial: Numerous factors regulate vitamin D levels.- Gastrointestinal health root cause approach.Thanks for tuning in!Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessFollow Chloe on TikTok @chloe_c_porterVisit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more!
In this episode, we discuss the gut-immune axis and Small Intestinal Fungal Overgrowth (SIFO), with a mechanistic focus on immune activation and epithelial barrier disruption. We detail contributing factors to and symptoms of SIFO. We further discuss the anatomical positioning and immunological functions of mast cells within the lamina propria, highlighting mast cell activation syndrome, while detailing how SIFO and SIBO can serve as upstream triggers for mast cell activation.Topics:1. The Gut-Immune Axis and Mast Cells - The intestinal epithelium forms the innermost selective barrier, coated in a protective mucus layer.- Immediately beneath lies the lamina propria, rich in immune cells including mast cells. 2. Mast Cells in the Lamina Propria - Mast cells are positioned near nerves, capillaries, lymphatics, and epithelial cells within the lamina propria.- Their anatomical location enables rapid immune surveillance and inflammatory response.- Mast cell granules store histamine and more. 3. Mast Cell Mediators - Histamine: Biogenic amine, inflammatory signaling.- Tryptase: A serine protease.- Cytokines and lipid mediators also released upon activation. 4. Mast Cell Activation Syndrome (MCAS) - Systemic: skin, respiratory tract, cardiovascular system, nervous system, and more.- The gastrointestinal tract.- Common triggers for mast cell activation. 5. Transition to Small Intestinal Fungal Overgrowth (SIFO) - Overgrowth of fungal organisms, often candida species, within the small intestine.- Contributing factors including hypochlorhydria, slowed motility, immune suppression, disrupted bacterial populations.- Overlap: SIFO, SIBO 6. Hypochlorhydria and the Stomach's Defense Role - Parietal cells secrete hydrochloric acid (HCl) and intrinsic factor.- HCl denatures proteins and sterilizes ingested pathogens.- Chief cells secrete pepsinogen, which becomes pepsin in acidic conditions to digest proteins.- Consequences of Reduced Gastric Acidity 7. The Role of Intestinal Motility - Enteric nervous system (ENS), myenteric and submucosal plexuses.- Coordinated contractions preventing stasis and microbial overgrowth. 8. Common Symptoms of SIFO and clinical overlap with SIBO 9. Candida and Fungal Pathophysiology in the Gut - Yeast form, regulated by microbial competition and immune defenses.- Hyphal transformation.- Degrade the mucus layer, disrupt epithelial integrity, trigger inflammation. 10. Secretory IgA and Mucosal Defense - Chronic stress, immune dysfunction, dysbiosis can lower sIgA levels and weaken mucosal immunity. 11. SIFO, SIBO, and Mast Cell Activation 12. Conclusion - Root cause approach, multi-factorial Thanks for tuning in!Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellnessFollow Chloe on TikTok @chloe_c_porterVisit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more!
If you're looking to lose serious weight, then you're going to want to pay close attention to this lesson. I will be sharing with you 3 fasting schedules that allow your metabolism to burn stubborn fat. Whether you've never practiced fasting before, or have been practicing fasting for years, you will benefit from this lesson. I've taken the information you're about to learn from my brand new book, Metabolic Freedom, which will be released on May 13th 2025, but you can pre order now and get $997 in FREE gifts. Let's start with the first fasting schedule, 12 hours. Lower insulin Complete digestion Redistribute blood flow (energy diversion) The second fasting schedule is 36 hours, here's what happens inside your body during this timeframe. Intestinal stem cells reboot Autophagy and mitophagy is enhanced Insulin drops significantly (serious fat loss) Muscle is preserved via growth hormone The third fasting schedule is a 48 hour fast. This resets your dopamine receptors. Scenesscent zombie cells get removed via apoptosis More fat loss is achieved through enhanced ketone production. Brain gets fired up. Inflammation and oxidative stress dramatically reduced. Spiritual feeling. BDNF boost The ideal rotation for fat loss… You're done eating Sunday at 6pm… Continue fasting until Tuesday at 6pm (48 hour fast complete) Wednesday: eat 3 meals per day, 8am, 12pm, 6pm (12 hour fast) Thursday eat 3 meals per day, 8am, 12pm, 6pm (12 hour fast) Friday eat 3 meals per day, 8am, 12pm, 6pm (12 hour fast) Fast from Friday 6pm until Sunday morning at 6am (36 hour fast complete), then eat at 12pm and then 6pm on Sunday. Links and Resources: