Podcast appearances and mentions of Gene expression

These tiny but tough life forms may help astronauts survive in the harsh environment of space.

Epicrispr Biotechnologies is using CRISPR to modulate the expression of disease-causing genes without making cuts to DNA. Its lead program is in development to treat FSHD, a genetic disorder that causes progressive weakness in the muscles of the face, shoulders, and upper arms. We spoke to Amber Salzman, CEO of Epicrispr, about how its one-and-done therapies work to target the epigenome, the company's lead program in FSHD, and the broader applications for its therapeutic approach.

In this episode of the Change Life Destiny podcast, we sit down with Kim Ressler, founder of SNIP Nutrition, to explore how nutrigenomics—the science of how nutrition impacts gene expression—is transforming functional health.After years of dealing with chronic health issues and ineffective treatments, Kim discovered the power of personalized genetic testing. She now helps others optimize energy, gut health, mood, and inflammation through tailored, one-formula supplements based on their unique DNA.Kim breaks down the science behind actionable genes, the limitations of traditional testing, and how understanding your genetic blueprint can simplify your health journey. Whether you're managing chronic fatigue, poor sleep, or looking to level up your biohacking game, this conversation is packed with powerful takeaways.Connect with Kim ResslerWebsite- https://snipnutrition.com/us/about_us/LinkedIn- https://www.linkedin.com/in/kimresslerInstagram- https://www.instagram.com/kimressler/Change Life & Destiny is a movement to excite, engage, and educate communities about the importance of taking control of our health and wellness. We highlight the latest and greatest technologies that can restore health, prevent disease, and promote wellness, as well as practitioners who are using cutting-edge technology to help patients take control of their health.Learn more about us here:Website: https://www.changelifedestiny.com/Instagram: https://www.instagram.com/changinglifedestiny/LinkedIn: https://www.linkedin.com/company/changelifedestiny/YouTube: https://www.youtube.com/@changelifedestinyFacebook: https://www.facebook.com/changelifedestinyWant to learn more? Visit our website or follow us on Instagram, Facebook Youtube, and LinkedIn.

My guest is Dr. Melissa Ilardo, Ph.D., professor of biomedical informatics at the University of Utah. We discuss the interplay between genes and behaviors, including how certain behaviors can improve resilience by changing gene and organ function, as well as natural selection events happening in humans today. We also discuss the immune system–related reasons people find the smells of potential mates attractive—or not. We explore how physical and psychological traits are passed from one generation to the next, and the specific behaviors that can influence gene expression to improve health and performance. Melissa explains her lab's pioneering research on breath-hold training and how activation of the dive reflex through breath holding can significantly improve oxygen availability by changing spleen size and function. We also delve into the medical uses and ethics of gene editing to cure disease in both babies and adults. For those interested in genes and inheritance, human performance, immune system function, and natural selection, this episode illustrates the remarkable interplay between human nature and nurture. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Joovv: https://joovv.com/huberman Eight Sleep: https://eightsleep.com/huberman LMNT: https://drinklmnt.com/huberman Function: https://functionhealth.com/huberman Timestamps 00:00:00 Melissa Ilardo 00:02:35 Nature vs Nurture, Gene Expression, Eye Color 00:07:06 Sponsors: Joovv & Eight Sleep 00:10:24 Epigenetics, Trauma, Mutations; Hybrid Vigor, Mate Attraction 00:15:47 Globalization; Homo Sapiens, Mating & Evolution; Mutations 00:25:28 Sea Nomads, Bajau & Moken Groups; Free Diving, Dangers & Gasp Reflex 00:32:52 Cultural Traditions, Free Diving & Families; Fishing 00:35:36 Mammalian Dive Reflex, Oxygen, Spleen, Cold Water & Face; Exercise 00:42:43 Sponsors: AG1 & LMNT 00:46:00 Free Diving, Spleen, Thyroid Hormone, Performance Enhancement 00:52:00 Dive Reflex, Immune System; Swimming & Health; Coastal Regions & Genetics 00:55:17 Female Free Divers, Haenyeo, Cold Water, Age, Protein 01:03:20 Human Evolution & Diet, Lactase, Fat 01:05:07 Korean Female Free Divers & Adaptations, Cardiovascular, Pregnancy 01:10:13 Miscarriages & Genetic Selection; Bajau, External Appearance, Mate Selection 01:17:15 Sponsor: Function 01:19:03 Free Diving, Underwater Vision; Super-Performers & Genetics 01:25:01 Cognitive Performance, Autism, Creativity; Genetic Determinism & Mindset 01:36:30 Genetics & Ethics, CRISPR, Embryo Genetic Screening 01:44:36 Admixture, Genetics; Are Humans a Single Species? 01:49:39 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Did you know that your genes are not your destiny? In this episode of Heal Yourself with Sarah Dawkins, we explore the fascinating world of epigenetics and how you can influence your gene expression for optimal health. Discover how lifestyle choices like nutrition, stress management, sleep, and movement can activate healing genes and suppress those linked to illness.Key Topics:-How gene expression works and why it matters-The powerful role of epigenetics in health and healing-Nutrition, stress, sleep & movement—how they influence your genes-Practical steps to take control of your genetic potential-Real-life inspiration: transforming health through small changesTune in to learn how to reprogram your biology and take charge of your health! Heal Naturally. Live Fully. www.sarahdawkins.com #epigenetics #dna #geneexpression #thekeys #healingjourney #Epigenetics #GeneExpression #SelfHealing #HolisticHealth #YouCanHealYourself #MindBodyConnection #DNAHealth #WellnessJourney #Biohacking #HealingNaturally

Scientific discovery happens in the lab—but it starts with curiosity and determination. In this episode of Absolute Gene-ius, we welcome Valeria Rangel, a PhD candidate at the University of California Irvine, who shares her research on acute lymphoblastic leukemia and the innovative ways digital PCR is helping uncover genetic patterns linked to cancer in Hispanic populations.Val's work focuses on Philadelphia chromosome-like (Ph-like) B-cell acute lymphoblastic leukemia, a rare and aggressive form of cancer. She explains how her lab uses digital PCR to detect mutations with high precision, identify risk factors in certain populations, and even validate findings using CRISPR-Cas9 gene editing. Through her research, Val sheds light on the role of SNPs, methylation patterns, and translocations in leukemia progression—demonstrating how digital PCR is transforming the way we approach cancer research.Beyond the science, Val takes us on her personal journey, from struggling to break into research due to financial barriers to finding her passion in oncology. In this episode's Career Corner, she shares valuable advice for aspiring scientists, tips for landing research opportunities, and some of her most hilarious and humbling lab moments (yes, she has broken multiple pipettes).Visit the Absolute Gene-ius pageto learn more about the guests, the hosts, and the Applied Biosystems QuantStudio Absolute Q Digital PCR System. 

Dr. Hoffman continues his conversation with Dr. Sharon Bergquist, author of "The Stress Paradox: Why You Need Stress to Live Longer, Healthier, and Happier." 

Dr. Sharon Bergquist is an award-winning physician, innovative healthcare leader, and visionary researcher, renowned for spearheading a science-based approach to applying lifestyle as medicine. She is the author of "The Stress Paradox: Why You Need Stress to Live Longer, Healthier, and Happier." She discusses the misunderstood role of stress, emphasizing its potential benefits when managed and utilized correctly. Dr. Bergquist explains how stress can enhance cellular function, boost resilience, and improve overall health. She delves into topics such as the physiology of stress, the science of hormesis, and the benefits of controlled stressors including plant toxins, thermal exposure, fasting, exercise, and psychological challenges. The discussion underscores the importance of balancing stress and recovery to promote cellular repair and long-term well-being.

Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/

Send us a textIn this episode of the Life Science Success Podcast my guest is Michael Edwards, the founder and CEO of Bioinfo Solutions LLC, a data analytics company specializing in extracting insights from complex biological information. Dr. Edwards brings over two decades of experience in genomics, spanning from laboratory research to teaching data science and bioinformatics, with a passion for deciphering the genetic language of cells.00:00 Introduction to Life Science Success Podcast00:38 Sponsor Message: Bio on the Bayou 202502:12 Guest Introduction: Michael Edwards02:36 Michael's Journey into Genomics and Bioinformatics05:07 Key Milestones in Michael's Career08:18 Founding Bioinfo Solutions09:31 Diverse Projects and Client Engagements15:38 The Role of Bioinformatics in Modern Research22:28 Challenges and Insights in Data Analysis27:00 Exploring Methodologies and Exciting Projects28:05 Gene Expression as a Language30:22 Future of AI in Bioinformatics31:17 Networking and Data Visualization32:20 AI and Automation in Various Fields38:12 Importance of Statistics and Data Visualization41:09 Broadening Skills and Tools in Bioinformatics44:07 Inspiration and Concerns in Science48:52 Concluding Thoughts and Reflections

Dr. Michael Klaper presents the scientific evidence behind disease reversal through plant-based nutrition. Discover how dietary changes can lead to significant health improvements and disease prevention. #PlantBasedNutrition #DiseaseReversal #HealthScience

In this data driven episode of Growing Older, Living Younger, Dr. Gillian Lockitch welcomes Emma Tekstra, actuary, global health consultant, and author of How to Be a Healthy Human: What Your Doctor Doesn't Know About Health and Longevity. You'll discover how data-driven insights challenge conventional health wisdom and why your lifestyle choices—not just your genes—determine how you age. Emma shares how traditional health care often fails you, why many medical myths persist, and what doctors don't tell you about optimizing longevity. You'll learn how nutrition, fasting, and movement influence gene expression, how to strengthen your immunity naturally, and why pharmaceuticals may be doing more harm than good. Emma also reveals the biggest contributors to cognitive decline and the essential habits you need to keep your brain sharp and resilient. If you want to take control of your health, cut through misinformation, and create a personalized plan for aging youthfully, this episode is packed with actionable insights. Take charge of your future and discover the real secrets to living younger, longer! Episode Timeline: 0:01 Introduction to the Podcast and Guest 4:12 Emma Tekstra's career journey 8:59 A Critique of Conventional Healthcare and Advice 16:09 How Lifestyle Choices may influence Gene Expression  22: 11 Strengthening Immunity and Resilience 28:23 Principles of a Healthy Diet 33:08 Strategies for Cognitive Wellness 36:15 Misconceptions in Conventional Healthcare 39:12 Practical Steps for Improving Wellness 40:33 Conclusion and Final Thoughts Action Steps: Schedule a free call about wellness and longevity with Dr. Gillian Lockitch Learn about Emma Telstra and "How to Be a Healthy Human: What Your Doctor Doesn't Know About Health and Longevity." www.EmmaTekstra.com https://www.linkedin.com/in/talk2emma/ https://www.instagram.com/emmatekstra/ https://emmatekstra.substack.com/ If you have not already done so, please rate and review the Growing Older Living Younger podcast and help spread the word about promoting healthy longevity. 

Join Suzie Senk and Dr. William B. Grant as they delve into the powerful benefits of sunlight and quality sleep for optimal health. Learn how to harness these natural elements to boost vitality and enhance overall well-being. #SunlightBenefits #QualitySleep #OptimalHealth

March 2025 Journal Club Podcast Title: Gene Expression Changes Associated With Recurrence After Gross Total Resection of Newly Diagnosed World Health Organization Grade 1 Meningioma To read journal article: https://journals.lww.com/neurosurgery/fulltext/2025/03000/gene_expression_changes_associated_with_recurrence.6.aspx Author: Ramin Morshed Guest Faculty: Tomas Garzon-Muvdi Moderator: Kimberly Hoang Resident Planner: Alexander Himstead

Imagine detecting cancer with just a single drop of blood. In this episode of the Beautifully Broken Podcast, host Freddie Kimmel engages in a compelling conversation with Dr. Joshua Routh, MD, a distinguished expert in pathology and molecular oncology. Dr. Routh serves as the Laboratory Director for high-complexity clinical laboratories and holds the position of Associate Professor of Pathology at Midwestern University. He is also the Medical Director for Precision Epigenomics Inc., where he focuses on multi-cancer early detection tests.Together, they examine the science behind EPISEEK, discussing how it analyzes epigenetic markers in the blood to identify potential cancer signals. The conversation covers the importance of methylation in gene expression, the emotional implications of cancer testing, and who should consider getting tested. Dr. Routh emphasizes the need for patient autonomy and informed decision-making in the context of cancer screening. They also explore the advancements in multi-cancer early detection tests, focusing on the technology behind EPISEEK, its cost, and the current lack of insurance coverage. The discussion touches on the implications of abnormal test results, the importance of patient-doctor collaboration, and the need for a holistic approach to health that includes lifestyle factors. Additionally, they discuss the strengths and limitations of current cancer detection technologies and the importance of comprehensive health monitoring.Highlights1:32 Introduction: Personal Reflections on the Importance of Early Cancer Detection3:05 Understanding EpiSeek: A Breakthrough in Liquid Biopsy Technology for Cancer Detection5:40 The Science of EpiSeek: How It Works to Detect Cancer Early8:14 The Role of Methylation in Gene Expression and Its Link to Cancer Growth10:42 Gene Expression and Epigenetics: Why They Matter in Cancer Screening13:20 Interpreting Test Results: What to Do After Receiving an Abnormal Finding16:35 Who Should Get Tested? Assessing Risk Factors, Family History, and Lifestyle19:48 The Emotional Impact of Cancer Screening and the Decision Not to Test22:14 Comparing EpiSeq to Other Multi-Cancer Early Detection Tests25:52 Insurance Coverage for Multi-Cancer Tests: Current Challenges and Future Prospects29:30 Next Steps After an Abnormal Test Result: Further Screening and Actions33:40 The War on Cancer: How Lifestyle Choices Influence Cancer Risk36:15 - Evaluating the Strengths and Limitations of Current Cancer Detection Technologies40:28 - The Importance of Comprehensive Health Monitoring Beyond Single TestsUPGRADE YOUR WELLNESSEpiSeq Test: https://www.precision-epigenomics.com/episeqExclusive $50 Discount Offer (Valid Until August 1, 2025): https://www.precision-epigenomics.com/offerSilver Biotics Muscle Cream: https://www.silverbiotics.com (Use Code: BEAUTIFULLYBROKEN for Discount)Saga Bands: https://ca.saga.fitness/?ref=titvyccmCode: beautifullybrokenStemRegen: https://www.stemregen.co/products/stemregen?_ef_transaction_id=&oid=1&affid=52Code: beautifullybrokenLightPathLED https://lightpathled.pxf.io/c/3438432/2059835/25794Code: beautifullybroken CONNECT WITH FREDDIE Check out my website and store: (http://www.beautifullybroken.world) Instagram: (https://www.instagram.com/beautifullybroken.world/) YouTube: (https://www.youtube.com/@BeautifullyBrokenWorld)

Guest Kristy Red-Horse is a biologist who specializes in coronary artery development and disease. She says the latest advances in treatment of blockages could do away with invasive bypass surgeries in favor of growing new arteries using molecules like CXCL12, known to promote artery regrowth in mice. Red-Horse explains how leaps forward in medical imaging, expanding atlases of gene expressions, and new drug delivery mechanisms could someday lead to trials in humans. But, before that day can arrive, much work remains, as Red-Horse tells host Russ Altman in this episode of Stanford Engineering's The Future of Everything podcast.Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your quest. You can send questions to thefutureofeverything@stanford.edu.Episode Reference Links:Stanford Profile: Kristy Red-HorseKristy's Lab: Red-Horse LabConnect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces Kristy Red-Horse, a professor of biology at Stanford University.(00:03:46) Replacing Open-Heart SurgeryWhy bypass surgery is invasive, risky, and requires long recovery.(00:05:09) Challenges in Artery GrowthThe difficulty of targeting artery growth with medical interventions.(00:07:32) The Role of Collateral ArteriesDefinition and function of collateral arteries as natural bypass.(00:09:37) Triggers for Natural Bypass FormationGenetic factors that may influence the growth of these bypass arteries.(00:10:49) Unique Properties of Coronary ArteriesChallenges of ensuring artificial growth replicates natural artery function.(00:13:04) The Discovery of CXCL12A key molecule that stimulates collateral artery formation.(00:16:16) Precise Artery Growth ControlThe results of targeted CXCL12 injections into mice hearts.(00:17:32) CXCL12's Overlooked RoleThe molecule's role in the immune system and stem cells.(00:20:27) Guinea Pigs and Heart Attack ResistanceHow guinea pigs naturally develop collaterals.(00:23:19) Preventing Heart DiseaseUsing artery growth treatments to target early-stage coronary disease.(00:25:25) Breakthroughs in Imaging TechnologyNew technology that enables identification of collateral growth pathways.(00:27:07) How Collateral Arteries FormThe two mechanisms in which new arteries form.(00:28:48) The Future of Medical Artery GrowthThe possibility of eliminating bypass surgery with targeted artery growth. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook

In this episode, we explore the intricate world of autism research with Jill Escher, a dedicated philanthropist, lawyer, and parent to two Autistic young adults. Jill's journey into Autism advocacy was sparked by her children's diagnoses, with no prior family history, leading her to significant roles like president of the National Council on Severe Autism and leadership at the Autism Society in the San Francisco Bay Area. Through the Escher Fund for Autism, she examines the causes beyond genetics, investigating how environmental and biological factors might alter gene expression, contributing to Autism's heritability.Jill challenges the conventional genetic focus in Autism research, arguing that it fails to explain the increasing prevalence of Autism. She delves into complex topics like epigenetics and transcriptional regulation, proposing these might unlock the heritability puzzle of Autism. Her research includes looking at how factors like general anesthesia can affect future generations. Escher also discusses the hurdles in Autism research, including scientific dogma and the influence of the neurodiversity movement, urging for a more comprehensive approach to address what she sees as a looming national health crisis.Jill Escher https://www.jillescher.comHarvard Presentation: https://harvard.zoom.us/rec/play/n1wZBC2hwCOid8oKlQJLJECY7cGS0YeQMNlaSaFqu2Iybo8ADCEzrdqP01Q3lXTBRX73GHgWdYZMg5RT.Vwh6LCxdweMaleLf?canPlayFromShare=true&from=share_recording_detail&startTime=1733338808000&componentName=rec-play&originRequestUrl=https%3A%2F%2Fharvard.zoom.us%2Frec%2Fshare%2Fy3NWE-vbqRQB-lnpZ33Gk7HsbiTJPzi4xjXdCDudRMYtdNFYYC-URWaix3xiYe1e.22MUxTE70Dl-Yz62%3FstartTime%3D1733338808000Other ResourcesAutism and the Womb https://youtu.be/NOVp4mIrougThe Relationship of the Placenta, Womb, and Development https://youtu.be/Mj5h5DOMcRw0:00 Intro1:18 Jill's Journey into Autism4:25 Jill's Family & Autism7:19 Research & Advocacy in Autism10:19 Genetic & Heritability Explanation13:05 Non-Genetic Factors; Epigenetics21:08 Anesthesia; Germ Cell; Proliferation26:29 Early Brain Development; Gene Expression; RNA; Molecular level27:56 Research needs; Genetics & Dead End data; Society & Preparation of Prevalence33:57 Rates of Autism & Future (& Current) Emergency38:16 Vaccination41:25 Migration; Excitation/Inhibition Imbalance; Functional Connectivity48:02 Barriers in Autism; Jill's Contact Information53:33 Reviews/RatingsX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: info.fromthespectrum@gmail.com

DSPod SOLO returns for a conversation about a recent edition of “you can just do things,” where Github CEO Nat Friedman and company tested the levels of endocrine disrupting chemicals in 700 common food items. And friends, it does not look good! We dig through the data to pull out some trends that can help us avoid getting slowly poisoned by our food, try to figure out if akshually no it's fine that there's plastics everywhere, and debate if there's a better way of naming these chemicals that reflects their ball-crushing nature. Don't miss the historic cosmology summit in Portugal this summer!!! DEMYSTICON 2025 ANNUAL MEETING June 12-16: https://demystifysci.com/demysticon-2025 PATREON: get episodes early + join our weekly Patron Chat https://bit.ly/3lcAasB MERCH: Rock some DemystifySci gear : https://demystifysci.myspreadshop.com/all AMAZON: Do your shopping through this link: https://amzn.to/3YyoT98 SUBSTACK: https://substack.com/@UCqV4_7i9h1_V7hY48eZZSLw@demystifysci (00:00) Go! (00:01:37) Beyond the Big Bang Conference in Portugal (00:06:16) Industrial Production Suspicion (00:13:26) Research and Remediation (00:22:54) Forest Fire Fighting Anecdotes (00:25:38) Plastic Research Approach (00:33:04) Plastic Contaminants in Food (00:45:00) Regulations and Lobbying (00:50:07) Inconsistent Chemical Testing (00:54:06) Thermal Receipts and Chemical Exposure (01:00:08) Fast Food and Plasticizers (01:05:25) Impact on Gene Expression (01:10:12) Phthalates and Hormonal Disruption (01:14:40) Phthalates in Food Products (01:17:46) Phthalates Effects on Reproduction (01:25:00) Comprehensive Chemical Safety Research (01:29:56) Testing and Chemical Awareness (01:31:06) Bias and Precommitment #PlasticPollution, #FoodSafety, #EndocrineDisruptors, #SustainableLiving, #PlasticFree, #CleanLiving, #ResearchMatters, #HealthierFuture, #EcoFriendlyLife, #philosophypodcast, #sciencepodcast, #longformpodcast Check our short-films channel, @DemystifySci: https://www.youtube.com/c/DemystifyingScience AND our material science investigations of atomics, @MaterialAtomics https://www.youtube.com/@MaterialAtomics Join our mailing list https://bit.ly/3v3kz2S PODCAST INFO: Anastasia completed her PhD studying bioelectricity at Columbia University. When not talking to brilliant people or making movies, she spends her time painting, reading, and guiding backcountry excursions. Shilo also did his PhD at Columbia studying the elastic properties of molecular water. When he's not in the film studio, he's exploring sound in music. They are both freelance professors at various universities. - Blog: http://DemystifySci.com/blog - RSS: https://anchor.fm/s/2be66934/podcast/rss - Donate: https://bit.ly/3wkPqaD - Swag: https://bit.ly/2PXdC2y SOCIAL: - Discord: https://discord.gg/MJzKT8CQub - Facebook: https://www.facebook.com/groups/DemystifySci - Instagram: https://www.instagram.com/DemystifySci/ - Twitter: https://twitter.com/DemystifySci MUSIC: -Shilo Delay: https://g.co/kgs/oty671

In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden interviews Dr. Timothy Spector, a leading expert in gut microbiome research. They discuss the importance of the gut microbiome for overall health, insights from twin studies, and the impact of diet and environment on gut health. Dr. Spector shares his journey from rheumatology to microbiome research, emphasizing the need for personalized nutrition and the role of diversity in the gut. The conversation also touches on the interplay between gut health, aging, and the immune system, as well as practical tips for improving gut health through diet and lifestyle changes.    FOR THE AUDIENCE:  * Take the ZOE quiz for free → https://zoe.com/how-it-works   * Use code ‘Podcast10' to get 10% OFF your supplements at our store → https://gladdenlongevityshop.com/     Takeaways    * The gut microbiome is essential for a functioning immune system.  * Genetics plays a minimal role in determining gut microbiome composition.  * Diversity in the gut microbiome is linked to better health outcomes.  * Eating a variety of plants can enhance gut health.  * Probiotics from food sources are more beneficial than supplements.  * The gut microbiome can influence mood and energy levels.  * Environmental factors have a significant impact on gut health.  * Restoring gut health can improve symptoms of various conditions.  * The gut microbiome acts as a virtual organ, interacting with the immune system.  * Personalized nutrition is key to optimizing gut health.    Chapters    00:00 Introduction to Gut Health and Microbiome Research  04:19 The Journey of Dr. Timothy Spector  07:14 Understanding the Microbiome's Role in Health  10:21 Insights from Twin Studies on Microbiome  13:14 Genetics vs. Environment in Microbiome Composition  16:30 The Gut Microbiome's Impact on Gene Expression  19:19 The Gut as an Ecosystem  22:13 The Complexity of a Healthy Gut Microbiome  25:32 The Role of Parasites in Gut Health  28:23 Diversity in Gut Microbiomes: A Key Indicator  31:11 Compensating for Modern Lifestyle Effects on Gut Health  33:32 The Importance of Diet and Gut Health  36:25 Understanding Prebiotics, Probiotics, and Postbiotics  41:16 Personalized Nutrition and the ZOE Test  44:12 Linking Gut Microbiome to Health Outcomes  52:59 Improving Gut Health and Addressing Symptoms  57:24 The Gut Microbiome and Immune System Connection  01:00:53 Aging, Inflammation, and Gut Health  01:04:33 Exploring ZOE and Its Offerings  01:07:53 Goodbye    To learn more about Tim's work and/or ZOE:  Website: https://zoe.com/   Instagram: @zoe: https://www.instagram.com/zoe   TikTok: https://www.tiktok.com/@join_zoe   Facebook: https://www.facebook.com/joinzoe1   Food for Life cookbook by Tim Spector: https://www.amazon.com/Food-Life-Cookbook-bestselling-gut-health-ebook/dp/B0CTCBR3VB     Reach out to us!       Website: https://gladdenlongevity.com/        Email: podcast@gladdenlongevity.com        Facebook: https://www.facebook.com/Gladdenlongevity/       Instagram: https://www.instagram.com/gladdenlongevity/?hl=en        LinkedIn: https://www.linkedin.com/company/gladdenlongevity       YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw    

Jeffrey M. Smith delves into the intersection of health, diet, and disease with insights from indigenous wisdom and quantum perspectives. Discover holistic approaches to well-being. #IndigenousWisdom #QuantumHealth #HolisticWellness

We are bringing back Jeff Krasno, this week who discusses his health journey and the importance of homeostasis in maintaining good health. He shares his experience with chronic disease and the symptoms he experienced before his diagnosis. Jeff emphasizes the role of excess molecules, such as insulin, in creating resistance and the need for balance in our lives. He also explores the impact of extrinsic factors, such as social media and stress, on our health. In this conversation, Jeff Krasno discusses the adaptive nature of the human body and the positive effects of stress, such as increased metabolic rate and psychological resilience. He emphasizes the importance of community and social connections in promoting health and longevity. Jeff also explores the impact of social relationships on gene expression and highlights the correlation between loneliness and mortality.  Three reasons to listen to the whole podcast:  1. Dive into the importance of balance and homeostasis for maintaining optimal well-being.  2. Learn about the role of social media to the impact of stress, and gain practical tips for navigating the complexities of modern wellness. 3. Learn about Paleolithic stressors and embracing discomfort for growth.  Timestamps (00:00:00) Introduction and Sauna Podcast (00:03:08) Jeff's Health Issues and Diagnosis (00:08:54) Early Symptoms and Missed Doctor's Appointments (00:13:07) Excess of Molecules and Insulin Resistance (00:23:40) Extrinsic Factors and Chronic Disease (00:27:32) The Adaptive Human Body (00:28:26) The Importance of Community (00:30:21) The Impact of Social Connections on Gene Expression (00:31:48) Loneliness and Mortality (00:36:32) Imposing Paleolithic Stressors (00:39:17) The Benefits of Fasting (00:42:13) Finding the Space Between Stimulus and Response (00:45:19) Embracing Discomfort and Cultivating Awareness (00:47:24) Well-being as a Process (00:51:54) The Power of Stressful Conversations (00:54:30) Feeling Radically Loved in Chosen Solitude Connect with Jeff Krasno: Good Stress https://www.onecommune.com/good-stress-jeff-krasno-free-pass-sign-up Instagram https://www.instagram.com/jeffkrasno/  Podcast https://www.onecommune.com/blog?tag=podcast  Enjoy the Podcast? Love to give us 5 stars? Help us reach more people and make them feel loved. A simple way is to share what you've learned today on social media. Don't forget to follow and message us on these platforms! Instagram: https://www.instagram.com/rosieacosta/ Twitter: https::twitter.com/rosieacosta Facebook: https://www.facebook.com/radicallylovedrosie TikTok: https://www.tiktok.com/@itsrosieacosta Website: https://www.radicallyloved.com/ Get You Are Radically Loved the book: https://www.radicallyloved.com/book Try Headspace for 30 days free! use code: ROSIE30  www.headspace.com Sign up for 'The Mindful Love Hub' on Substack: https://radicallyloved.substack.com?utm_source=navbar&utm_medium=web&r=2t314w Create a daily meditation ritual in just seven days! Download BUILD YOUR DAILY MEDITATION RITUAL and other freebies at https://www.radicallyloved.com/free-stuff!   Connect with Tessa Tovar: Website: https://tessatovar.com/   Instagram: https://www.instagram.com/tessamarietovar/  YouTube: https://www.youtube.com/channel/UCHMYm-7kNZfulgaiCi2w8Cw Book of Poetry for Savasana: https://www.amazon.com/Dark-Moon-Book-Poetry-Savasana/dp/1731243588

Do you know your biological age? How does one learn their biological age and how is it different from your chronological age? The answer lies in our epigenetics, which is how you live your life! In this fascinating episode of Salad with a Side of Fries, Jenn welcomes Hannah Went, co-founder of TruDiagnostic, to explore the science behind biological age testing. Together, they dive into the cutting-edge world of epigenetics, methylation, and the role of lifestyle in optimizing health. From understanding how epigenetic markers can predict disease risks to uncovering how simple changes can slow aging, this episode is packed with insights that could transform how you think about your health and longevity. The Salad With a Side of Fries podcast is hosted by Jenn Trepeck, discussing wellness and weight loss for real life, clearing up the myths, misinformation, bad science & marketing surrounding our nutrition knowledge and the food industry. Let's dive into wellness and weight loss for real life, including drinking, eating out, and skipping the grocery store. IN THIS EPISODE: [1:57] What is your biological age?[6:04]  Hannah describes epigenetics and what they target in the blood through various tests.[9:54] What is methylation?[12:53] How is epigenetic testing different from Elizabeth Holmes and Theranos?[15:38] What are the privacy implications of taking these tests, and what can the tests reveal?[22:49] Studies around epigenetic information.[25:42] Slowing the progression of biomarkers that create disease.[29:05] Lifestyle changes can positively impact stress and overall health[32:19] There is power in testing.[33:39] Choosing the most compatible testing company.KEY TAKEAWAYS: Genetics and epigenetics offer complementary insights into human biology. Genetics represents the fixed "hardware" inherited equally from each parent, while epigenetics is the dynamic "software" influenced by interactions with the environment and personal behaviors. Unlike static genetic markers, epigenetic markers are often changeable, though some—like imprint markers—may be inherited, presenting exciting opportunities for biomarker discovery.While the classification of aging as a disease may be debated, it's clear that biological age clocks are becoming powerful tools for detecting disease signals. For example, one clock has shown 92% accuracy in predicting mortality, compared to 72% for chronological age. These biomarkers are improving and will soon include methylation risk scores for specific diseases, helping to assess individual disease risks more precisely. Aging may serve as a general indicator, providing valuable insights into disease likelihood and guiding interventions for better health outcomes.Aging and health assessments, like biological age testing, can serve as a valuable wake-up call, especially for those with room for improvement in their health and lifestyle. While biohacking and excessive supplementation are popular, they often lack clarity and balance, making it difficult to pinpoint what's truly effective. Simplicity is vital—maintaining a balanced approach is more beneficial than overloading the body with too many interventions, which can disrupt homeostasis and lead to less favorable results.QUOTES: [6:19] “I like to break down the word. So epi is a Greek prefix that actually just means above or on top of. So we're quite literally just looking on top of your genetics.” Hannah Went[7:25] “You can change your epigenetics and control your health. You can no longer blame, you know, your predisposition for disease based on your second cousins.” Hannah Went [7:40] “We are in control of our health. Genetics are this predisposition, but not a determining, inherent absolute.” Jenn Trepeck[12:14] “Epigenetics is actually a better marker in some cases in terms of disease predictability, odds ratios, hazard ratio and that's the point of the biomarker. How close can we get to that disease prediction?” Hannah Went[14:03] “Epigenetic tests are not a replacement for traditional lab tests. Instead, they're just providing a unique layer of insight into how your environment and lifestyle may be affecting your particular genes.” Hannah Went[27:18] “We can look at these results and let it be a wake up call to say,  I may have different data so, I might want to make some lifestyle changes.” Jenn Trepeck[33:09] “You see things on social media nowadays, like ‘food is medicine'. ‘You are what you eat'. ‘Your DNA is not your destiny'.  That's epigenetics. They're quite literally describing epigenetics without saying the word.” Hannah Went[35:06] “People get confused between what's truly genetic and what is inherited lifestyle. Something might run in your family, that doesn't necessarily mean it's genetic because the other thing that runs in families is lifestyle choices and habits.” Jenn TrepeckRESOURCES:Become A Member of Salad with a Side of FriesJenn's Free Menu PlanA Salad With a Side of FriesA Salad With A Side Of Fries MerchA Salad With a Side of Fries InstagramNutrition Nuggets for Epigenetics EpisodeGUEST RESOURCES: Everything Epigenetics - PodcastTrudiagnostic - WebsiteEverything Epigenetics - InstagramEverything Epi - TwitterGUEST BIOGRAPHY: Hannah Went has a lifelong passion for longevity and breakthrough, disruptive technologies that drive radical improvement to the human condition. She attended the University of Kentucky and graduated with a degree in Biology. She had multiple research internships studying cell signaling and cell biology then. After graduation, she worked for the International Peptide Society as their Director of Research and Content. Through work in the integrative medicine industry, Hannah saw an opportunity for methylation-based age diagnostics and started TruDiagnostic in 2020. TruDiagnostic focuses on methylation array-based diagnostics for life extension and preventive healthcare, serving functional medicine providers. TruDiagnostic is committed to research, with over 30 approved clinical trials investigating epigenetic methylation changes in longevity and health interventions. Since TruDiagnostic's inception, they have created one of the world's largest private epigenetic health databases, with over 75,000 patients tested. Hannah has since created Everything Epigenetics, sharing insights on how DNA regulation impacts health. 

In this exciting new episode, Cody is joined by Dr. Layne Ellen Harris or Foresight Agronomics, to discuss gene expression analysis and how biologicals can affect the genes in the plants we grow. 

Kevelin Barbosa-Xavier is a PhD student in Plant Biotechnology at Universidade Estadual do Norte Fluminense Darcy Ribeiro (UENF) where she conducts research under the supervision of Thiago Motta Venancio. She is a computational biologist, investigating the genes and gene networks involved in plant secondary metabolic pathways and fiber production, specifically in the Cannabis sativa species. Kevelin and her team recently published a study titled Cannabis Expression Atlas: a comprehensive resource for integrative analysis of Cannabis sativa L. gene expression, along with a free online tool to help researchers analyze genomic sequence data. We discussed: The team's main objectives in creating the Cannabis Expression Atlas How our understanding of cannabis genomics compares to other commercial crops How gene expression data can advance plant breeding and genetic engineering Potential applications of the Cannabis Expression Atlas in commercial cannabis cultivation and more Thanks to This Episode's Sponsor: Medicinal Genomics Medicinal Genomics (MGC) uses its unmatched knowledge of the cannabis genome and the microbes affecting cannabis plants to create diverse testing solutions that improve crop yield, accelerate breeding programs, and ensure product safety. Growers and breeders use MGC's cannabis genome sequencing services to identify novel traits, stabilize genetics, and protect intellectual property. Additionally, Kannapedia.net provides bioinformatics and blockchain certification for cultivar authenticity. Learn more at medicinalgenomics.com Additional Resources Cannabis Expression Atlas: a comprehensive resource for integrative analysis of Cannabis sativa L. gene expression Cannabis Expression Atlas Register for CannMed 25 Meet the CannMed 25 Advisory Board Submit Your Abstract for CannMed 25 Review the Podcast CannMed Archive

Elizabeth Blackburn, Ph.D., examines the relationship between telomeres, cellular aging, and metabolic health, highlighting how telomere regulation differs between insulin-sensitive and insulin-resistant individuals. She discusses the effects of environmental factors—like glucose levels, stress hormones, and drugs—on telomere maintenance, which can disrupt cellular coordination and contribute to age-related diseases. Blackburn also shares insights from studies on hibernating lemurs, indicating that while their telomere health remains stable during metabolic slowdowns, it declines upon reactivation. Ultimately, she suggests that telomere maintenance could serve as a valuable biomarker for early signs of metabolic dysfunction, informing strategies for long-term health and resilience. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39944]

Elizabeth Blackburn, Ph.D., examines the relationship between telomeres, cellular aging, and metabolic health, highlighting how telomere regulation differs between insulin-sensitive and insulin-resistant individuals. She discusses the effects of environmental factors—like glucose levels, stress hormones, and drugs—on telomere maintenance, which can disrupt cellular coordination and contribute to age-related diseases. Blackburn also shares insights from studies on hibernating lemurs, indicating that while their telomere health remains stable during metabolic slowdowns, it declines upon reactivation. Ultimately, she suggests that telomere maintenance could serve as a valuable biomarker for early signs of metabolic dysfunction, informing strategies for long-term health and resilience. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39944]

Elizabeth Blackburn, Ph.D., examines the relationship between telomeres, cellular aging, and metabolic health, highlighting how telomere regulation differs between insulin-sensitive and insulin-resistant individuals. She discusses the effects of environmental factors—like glucose levels, stress hormones, and drugs—on telomere maintenance, which can disrupt cellular coordination and contribute to age-related diseases. Blackburn also shares insights from studies on hibernating lemurs, indicating that while their telomere health remains stable during metabolic slowdowns, it declines upon reactivation. Ultimately, she suggests that telomere maintenance could serve as a valuable biomarker for early signs of metabolic dysfunction, informing strategies for long-term health and resilience. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39944]

Elizabeth Blackburn, Ph.D., examines the relationship between telomeres, cellular aging, and metabolic health, highlighting how telomere regulation differs between insulin-sensitive and insulin-resistant individuals. She discusses the effects of environmental factors—like glucose levels, stress hormones, and drugs—on telomere maintenance, which can disrupt cellular coordination and contribute to age-related diseases. Blackburn also shares insights from studies on hibernating lemurs, indicating that while their telomere health remains stable during metabolic slowdowns, it declines upon reactivation. Ultimately, she suggests that telomere maintenance could serve as a valuable biomarker for early signs of metabolic dysfunction, informing strategies for long-term health and resilience. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39944]

Elizabeth Blackburn, Ph.D., examines the relationship between telomeres, cellular aging, and metabolic health, highlighting how telomere regulation differs between insulin-sensitive and insulin-resistant individuals. She discusses the effects of environmental factors—like glucose levels, stress hormones, and drugs—on telomere maintenance, which can disrupt cellular coordination and contribute to age-related diseases. Blackburn also shares insights from studies on hibernating lemurs, indicating that while their telomere health remains stable during metabolic slowdowns, it declines upon reactivation. Ultimately, she suggests that telomere maintenance could serve as a valuable biomarker for early signs of metabolic dysfunction, informing strategies for long-term health and resilience. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39944]

Elizabeth Blackburn, Ph.D., examines the relationship between telomeres, cellular aging, and metabolic health, highlighting how telomere regulation differs between insulin-sensitive and insulin-resistant individuals. She discusses the effects of environmental factors—like glucose levels, stress hormones, and drugs—on telomere maintenance, which can disrupt cellular coordination and contribute to age-related diseases. Blackburn also shares insights from studies on hibernating lemurs, indicating that while their telomere health remains stable during metabolic slowdowns, it declines upon reactivation. Ultimately, she suggests that telomere maintenance could serve as a valuable biomarker for early signs of metabolic dysfunction, informing strategies for long-term health and resilience. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39944]

Elizabeth Blackburn, Ph.D., examines the relationship between telomeres, cellular aging, and metabolic health, highlighting how telomere regulation differs between insulin-sensitive and insulin-resistant individuals. She discusses the effects of environmental factors—like glucose levels, stress hormones, and drugs—on telomere maintenance, which can disrupt cellular coordination and contribute to age-related diseases. Blackburn also shares insights from studies on hibernating lemurs, indicating that while their telomere health remains stable during metabolic slowdowns, it declines upon reactivation. Ultimately, she suggests that telomere maintenance could serve as a valuable biomarker for early signs of metabolic dysfunction, informing strategies for long-term health and resilience. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39944]

Here are the show notes for The James Altucher Show episode featuring Naveen Jain:A Note from James:“Oh my gosh. What a podcast with Naveen Jain. I first had Naveen on in 2014 or 2015, and he remembered it perfectly. That conversation was so fun, I still remember it like it was yesterday. It's crazy because I've done over 1,500 episodes, but that one stuck with me.Back then, we talked about Moon Express and his journey building rockets to the moon. Now, almost ten years later, Naveen has built several other companies, including Viome, which uses cutting-edge technology to analyze your microbiome and help people live longer healthier lives. Today, we're talking about his new book, The Youth Formula: Outsmart Your Genes and Unlock the Secrets to Longevity.At first, I'll admit, I was tired of hearing about longevity—everyone seems to be saying the same thing—but Naveen has such a unique take on it. We got into everything: from the role of microbes in our health to fecal transplants (yes, really) and how bacteria can influence personality traits. It was fascinating. We even talked about how changing your microbiome could literally alter your personality.There's so much in this episode that it's going to blow your mind. I hope it's not another ten years before we get Naveen back on the show. I'm definitely going to take him up on some of his suggestions, and maybe I'll have some results to share in a few months. Here's Naveen Jain.”Episode Description:In this episode, James Altucher is joined by serial entrepreneur Naveen Jain to explore the cutting-edge science of longevity, gut health, and human potential. Naveen, the founder of Viome and author of The Youth Formula, dives deep into how the microbiome shapes our health and even our personality. He explains why genes aren't destiny, how microbes may play a more important role in our health than DNA, and what steps we can take to live longer healthier lives. James and Naveen also discuss the surprising science behind fecal transplants, the future of personalized nutrition, and why finding purpose might be the ultimate key to longevity.What You'll Learn:How the microbiome plays a crucial role in your overall health—and might even affect your personality.Why DNA isn't as important as you think when it comes to disease and longevity.The latest research on fecal transplants and their impact on treating various diseases.How personalized nutrition can help you optimize your health based on your unique biology.The connection between purpose, community, and living a longer life.Timestamped Chapters:[01:30] Introduction: Reconnecting with Naveen Jain after 10 years[02:44] The Youth Formula and Viome: Outsmarting your genes[03:17] Microbiome's role in health: 99.999% of your body is microbes[04:02] Fecal transplants and personality: Can you inherit personality traits?[06:00] Personalized nutrition: Why “healthy” food isn't healthy for everyone[12:00] The power of purpose: Why having a reason to live is crucial for longevity[21:32] Changing the microbiome to treat disease: Fecal transplants and immunotherapy[29:24] How microbiomes affect mental health: Serotonin and gut-brain connections[39:51] The role of AI in personalized health recommendations at Viome[46:00] Stress and the sympathetic/parasympathetic modes: Modern stressors vs. ancient survival instincts[48:01] The role of exercise: Why 30-45 minutes of movement is enough[49:00] Sleep and health: The importance of quality over quantity[56:58] Entrepreneurial insights: Why a smooth life isn't what you want as an entrepreneur[58:07] Long-term vision: How Viome is focused on extending life by improving microbiome health[65:00] Wrap-up: James's thoughts on the future of health and Naveen's closing remarksAdditional Resources:The Youth Formula: Outsmart Your Genes and Unlock the Secret to LongevityViome: Learn more about personalized nutrition and microbiome analysis.Naveen Jain's Official Website ------------What do YOU think of the show? Head to JamesAltucherShow.com/listeners and fill out a short survey that will help us better tailor the podcast to our audience!Are you interested in getting direct answers from James about your question on a podcast? Go to JamesAltucherShow.com/AskAltucher and send in your questions to be answered on the air!------------Visit Notepd.com to read our idea lists & sign up to create your own!My new book, Skip the Line, is out! Make sure you get a copy wherever books are sold!Join the You Should Run for President 2.0 Facebook Group, where we discuss why you should run for President.I write about all my podcasts! Check out the full post and learn what I learned at jamesaltuchershow.com------------Thank you so much for listening! If you like this episode, please rate, review, and subscribe to “The James Altucher Show” wherever you get your podcasts: Apple PodcastsiHeart RadioSpotifyFollow me on social media:YouTubeTwitterFacebookLinkedIn

In Episode 153 of the PricePlow Podcast, we're joined by Danielle Citrolo, Vice President of Scientific and Regulatory Affairs at Kyowa Hakko USA, to discuss exciting new research on Cognizin Citicoline. Cognizin, an industry-leading nootropic ingredient known for its benefits in brain health, has long been praised for its ability to support focus, memory, and attention. In this episode, Danielle dives deep into the latest findings, highlighting the cutting-edge science behind how Cognizin impacts gene expression at the cellular level, offering fresh insights into how it supports cognitive function. Analyzing Cognizin Citicoline at the Genetic Level Danielle explains how recent studies using a sophisticated triculture model of brain cells revealed new mechanisms of action for citicoline. By examining gene expression and neuronal activity, researchers were able to uncover how Cognizin affects brain structure and function, from enhancing neuronal communication to promoting healthy cholesterol synthesis in the brain. These discoveries take the understanding of Cognizin's benefits to the next level, offering a deeper look at how this powerful nootropic works beyond just boosting focus and attention. Throughout the episode, Danielle also touches on the broader implications of this research, particularly in the areas of mitochondrial health and neuroprotection. With ongoing studies into its potential benefits for women's cognitive health, sleep quality, and mood regulation, Cognizin continues to lead the way in the nootropic industry. Whether you're a biohacker, a health enthusiast, or simply curious about the latest advancements in brain health, this episode is packed with exciting discoveries. https://blog.priceplow.com/podcast/danielle-citrolo-cognizin-genetic-research-153 Video: Daneille Citrolo of Kyowa Hakko Talks Cognizin Gene Research https://www.youtube.com/watch?v=g53Mb2PpEf8 (00:00) – Introduction to Danielle (02:15) – Exploring the New Study on Cognizin (07:15) – Understanding Metabolomics and Cognizin (12:15) – The Triculture Model Explained (18:00) – Gene Expression and Cognizin's Impact (23:45) – Future Research Directions and Applications (28:15) – Potential in Women's Health and Cognitive Function (36:30) – Conclusion and Future Studies Where to Find Danielle and Kyowa Hakko USA Sign up for PricePlow's Kyowa Hakko news alerts Danielle Citrolo on LinkedIn Kyowa Hakko USA on LinkedIn Thanks for joining us, Daneille! Please subscribe to the PricePlow Podcast on any platform and leave us reviews!

We explore the transformative research of Brian Dias on how environmental stressors and trauma can influence behavior and physiology across generations. Brian shares his personal motivation behind his scientific journey, discussing his impactful studies on chemosensation, the inheritance of behavioral sensitivities, and the potential for positive future legacies. We dive into the fascinating evidence from animal studies and explore the implications for human wellbeing and organizational behavior. This episode reveals both the challenges and opportunities in understanding and altering the epigenetic legacy of stress, offering insights into the biology of adaptation and resilience.   00:00 Introduction and Opening Mantra 00:48 Welcoming the Guest: Brian Dias 02:09 Exploring Environmental Stressors 03:17 Brian's Personal Journey and Scientific Mission 05:29 Chemosensation and Generational Impact 06:46 Cherry Blossom Study and Behavioral Sensitivity 09:02 Organizational Culture and Behavioral Transmission 13:35 Mechanisms of Stress Legacy Transmission 32:19 Epigenetics and Environmental Influences 49:20 Engineering Legacies of Flourishing 53:59 Concluding Thoughts and Future Directions     Trauma, Legacy, Epigenetics, Neuroscience, Stress, Gene Expression, Biological Response, Generational Trauma, Environmental Impact, Stress Response, Psychology, Human Behavior, Holocaust, 9/11, Scientific Research, Chemo Sensation, PTSD, Childhood Abuse, Brian Dias, Aidan McCullen   Towards understanding and halting legacies of trauma   Legacies of salient environmental experiences—insights from chemosensation   Fostering Respectful and Productive Conversations: Lessons Learned From Debating Courtyards in Tibetan Buddhist Monasteries   Dias Lab:

An introduction to the processes by which cells control which genes are expressed. We begin with an overview of why genetic regulation is necessary and the key stages where such regulation occurs, including key concepts such as transcription factors and DNA binding domains. We then discuss prokaryotic gene regulation, focusing on the lac operon in E. coli. We then expand the discussion to cover the various mechanisms of eukaryotic gene regulation, including chromatic remodelling, transcriptional regulation, post-transcriptional regulation, RNA editing, and micro RNAs. Recommended pre-listening is Episodes 34-35: DNA Structure and Function, and Episode 118: Cell Signalling. If you enjoyed the podcast please consider supporting the show by making a PayPal donation or becoming a Patreon supporter. https://www.patreon.com/jamesfodor https://www.paypal.me/ScienceofEverything

Curious about what happens to our cells as we age and how it affects our health? Shiri Gur-Cohen explores the role of tiny chemical tags on our DNA, like methylation, in influencing our healing and overall well-being. Gur-Cohen discusses how these tags might be shaped by our body's systems, such as the lymphatic system, and could even help repair or regenerate various parts of our body. Gur-Cohen proposes that uncovering these processes could lead to innovative ways to slow aging or boost our body's natural healing capabilities. Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 39979]

Curious about what happens to our cells as we age and how it affects our health? Shiri Gur-Cohen explores the role of tiny chemical tags on our DNA, like methylation, in influencing our healing and overall well-being. Gur-Cohen discusses how these tags might be shaped by our body's systems, such as the lymphatic system, and could even help repair or regenerate various parts of our body. Gur-Cohen proposes that uncovering these processes could lead to innovative ways to slow aging or boost our body's natural healing capabilities. Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 39979]

Curious about what happens to our cells as we age and how it affects our health? Shiri Gur-Cohen explores the role of tiny chemical tags on our DNA, like methylation, in influencing our healing and overall well-being. Gur-Cohen discusses how these tags might be shaped by our body's systems, such as the lymphatic system, and could even help repair or regenerate various parts of our body. Gur-Cohen proposes that uncovering these processes could lead to innovative ways to slow aging or boost our body's natural healing capabilities. Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 39979]

Curious about what happens to our cells as we age and how it affects our health? Shiri Gur-Cohen explores the role of tiny chemical tags on our DNA, like methylation, in influencing our healing and overall well-being. Gur-Cohen discusses how these tags might be shaped by our body's systems, such as the lymphatic system, and could even help repair or regenerate various parts of our body. Gur-Cohen proposes that uncovering these processes could lead to innovative ways to slow aging or boost our body's natural healing capabilities. Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 39979]

Curious about what happens to our cells as we age and how it affects our health? Shiri Gur-Cohen explores the role of tiny chemical tags on our DNA, like methylation, in influencing our healing and overall well-being. Gur-Cohen discusses how these tags might be shaped by our body's systems, such as the lymphatic system, and could even help repair or regenerate various parts of our body. Gur-Cohen proposes that uncovering these processes could lead to innovative ways to slow aging or boost our body's natural healing capabilities. Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 39979]

Want to know the secrets to optimal health and longevity?In this episode of the Happy Hustle Podcast, we're diving deep into the world of health optimization, longevity, and the miraculous powers of peptides. I recently had an enlightening conversation with Regan Archibald on the Happy Hustle Podcast, and trust me, you don't want to miss these golden nuggets of wisdom!Reagan is a leading peptide functional medicine and longevity specialist who's been transforming lives with his innovative approach to health and wellness. In our chat, we explored everything from leveraging data for personalized health strategies to tapping into the natural healing properties of peptides. If you're looking to level up your health and longevity game, tune in to this episode with Reagan Archibald. Peptides might just be the missing link you've been searching for. As always, make sure you do your homework and consult the experts before diving in. But once you do, the potential for growth—both physically and spiritually—is limitless.In this episode, we cover: 03:10 The Importance of Health Optimization07:07 Data and Testing in Health Optimization13:07 Understanding Peptides: Cell Signaling and Gene Expression16:20 Using Peptides to Address Health Issues22:51 Enhancing the Body's Natural Healing Properties with Peptides24:35 Different Approaches: Functional Medicine vs. Pharmaceutical Industry25:32 The Transformative Power of Peptides26:30 Proper Dosing and Expert Guidance27:15 Enhancing Muscle Growth, Detoxification, and Cell Communication29:19 The Healing Potential of Peptides30:08 Research and FDA-Approved Peptides34:45 Creating Magical Moments through Outdoor Activities36:41 Delayed Gratification and Wise InvestmentsConnect with Reganhttps://www.facebook.com/EastWestSaltLakehttps://www.facebook.com/ericjhinmanhttps://www.youtube.com/@EastWestHealth Find Regan on this website: https://acueastwest.com/ Connect with Cary!https://www.instagram.com/cary__jack/https://www.facebook.com/SirCaryJackhttps://www.linkedin.com/in/cary-jack-kendzior/https://twitter.com/thehappyhustlehttps://www.youtube.com/channel/UCFDNsD59tLxv2JfEuSsNMOQ/featured Get a free copy of his new book, The Happy Hustle, 10 Alignments to Avoid Burnout & Achieve Blissful Balance (https://www.thehappyhustlebook.com/)Sign up for The Journey: 10 Days To Become a Happy Hustler Online Course (http://www.thehappyhustle.com/Journey)Apply to the Montana Mastermind Epic Camping Adventure (https://caryjack.com/montana)“It's time to Happy Hustle, a blissfully balanced life you love, full of passion, purpose, and positive impact!”Episode Sponsor: Magnesium Breakthrough from BiOptimizersIf you've been on a restricted diet lately or maybe even taken some meds to shed those pounds for the summer, I gotta warn ya—be careful! You might have unknowingly created a nutrient deficiency that could not only mess with your health but also jeopardize those weight loss goals.Did you know that over 75% of Americans are already deficient in magnesium? Yeah, it's wild! Magnesium is this powerhouse mineral that's involved in over 600 biological reactions in your body. It helps with everything from sleep to stress management to hormone balance—all key players in keeping your weight on track.And if you're still on those meds, you might be dealing with some side effects like sleepless nights, digestive issues, or irritability, which can totally throw off your commitment to your goals. Whether you're taking meds or not, setting up healthy habits is crucial to maintaining your weight over time. One of the best things you can do? Make sure you're getting all the magnesium your body needs.Don't let a magnesium deficiency derail your progress! Give Magnesium Breakthrough by BIOptimizers a shot. Unlike other supplements, this one's got all 7 forms of magnesium that your body can actually absorb, so you get the full spectrum of benefits.This approach will help you crush your goals and maintain a healthy weight while keeping your overall health in check. For an exclusive offer, head to bioptimizers.com/happy and use the promo code 'happy10' at checkout to save 10%. And if you subscribe, you'll snag amazing discounts, free gifts, and a guaranteed monthly supply.

Cellular and molecular biologist Jason Buenrostro is one of 2023's MacArthur Foundation fellows. Buenrostro, who is also a Harvard University associate professor, studies the mechanisms that “turn on” genes, and is the pioneer of a popular method to assess chromatin accessibility across the genome. We spoke with Professor Buenrostro for Under the Radar's series, “The Genius Next Door.”

Broadcast from KSQD, Santa Cruz on 8-29-2024: Dr. Diana Schwarzbein explains the concept of damaged metabolism, focusing on building and using biochemicals in the body. Dr. Jeffrey Bland discusses metabolic syndrome, insulin resistance, and their widespread effects on various bodily systems. Dr. Mark Houston explores the relationship between insulin resistance, diabetes, and cardiovascular disease. Dr. David Perlmutter explains the connections between diabetes, inflammation, and neurodegenerative diseases like Alzheimer's and Parkinson's. The concept of food as information is introduced, highlighting how nutrients can influence gene expression and cellular function. The role of advanced glycosylation end products (AGEs) in aging and disease is discussed. The importance of fat cells as an endocrine organ and their impact on inflammation is explored. Mitochondrial function and oxidative stress are explained in relation to cellular health and disease. Dietary and lifestyle recommendations for reducing inflammation and improving overall health are provided by multiple speakers. The potential benefits of specific supplements like omega-3 fatty acids, vitamins C and E, and green tea extract are discussed. The speakers advocate for a more holistic, interconnected approach to medicine that addresses root causes rather than treating symptoms in isolation.

In this episode of the Epigenetics Podcast, we talked with Johnathan Whetstine from Fox Chase Cancer Center about his work on how histone demethylases affect gene expression and cancer cell stability. The Interview start by discussing a pivotal paper from Jonathan's lab in 2010, where they identified a role for the KDM4A histone demethylase in replication timing and cell cycle progression. They elaborate on the discoveries made regarding the link between histone marks, replication timing, and gene expression control. Jonathan explains the impact of microRNAs on regulating KDM4A and how protein turnover rates can influence cellular responses to treatments like mTOR inhibitors. Further, they explore the causal relationship between histone marks and replication timing, demonstrating how alterations in epigenetic regulation can affect genome stability. Jonathan shares insights from his latest research on H3K9 methylation balance at the MLL-KM2A locus, elucidating how these epigenetic modifications regulate amplifications and rearrangements in cancer cells. The episode concludes with a discussion on the establishment of the Cancer Epigenetics Institute at Fox Chase Cancer Center, aiming to bridge academia and industry to accelerate translational research in cancer epigenetics.   References Black, J. C., Allen, A., Van Rechem, C., Forbes, E., Longworth, M., Tschöp, K., Rinehart, C., Quiton, J., Walsh, R., Smallwood, A., Dyson, N. J., & Whetstine, J. R. (2010). Conserved antagonism between JMJD2A/KDM4A and HP1γ during cell cycle progression. Molecular cell, 40(5), 736–748. https://doi.org/10.1016/j.molcel.2010.11.008 Mishra, S., Van Rechem, C., Pal, S., Clarke, T. L., Chakraborty, D., Mahan, S. D., Black, J. C., Murphy, S. E., Lawrence, M. S., Daniels, D. L., & Whetstine, J. R. (2018). Cross-talk between Lysine-Modifying Enzymes Controls Site-Specific DNA Amplifications. Cell, 174(4), 803–817.e16. https://doi.org/10.1016/j.cell.2018.06.018 Van Rechem, C., Ji, F., Chakraborty, D., Black, J. C., Sadreyev, R. I., & Whetstine, J. R. (2021). Collective regulation of chromatin modifications predicts replication timing during cell cycle. Cell reports, 37(1), 109799. https://doi.org/10.1016/j.celrep.2021.109799 Gray, Z. H., Chakraborty, D., Duttweiler, R. R., Alekbaeva, G. D., Murphy, S. E., Chetal, K., Ji, F., Ferman, B. I., Honer, M. A., Wang, Z., Myers, C., Sun, R., Kaniskan, H. Ü., Toma, M. M., Bondarenko, E. A., Santoro, J. N., Miranda, C., Dillingham, M. E., Tang, R., Gozani, O., … Whetstine, J. R. (2023). Epigenetic balance ensures mechanistic control of MLL amplification and rearrangement. Cell, 186(21), 4528–4545.e18. https://doi.org/10.1016/j.cell.2023.09.009   Related Episodes The Impact of Chromatin Modifiers on Disease Development and Progression (Capucine van Rechem)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

In this episode of the Epigenetics Podcast, we talked with Claire Rougeulle from the Epigenetics and Cell Fate Center at Université Paris City on this show to talk about her work on gene expression control, the intricacies of X-chromosome inactivation, and the potential of non-coding RNAs in this process. In this episode Claire Rougeulle explains her discoveries regarding the transcription regulation of XIST by factors like YY1 and the erosion of X-chromosome inactivation in human pluripotent stem cells. She shares the complexity of distinguishing between epigenetics and transcriptional regulation, highlighting the challenges in studying allelic expression of X-chromosomes at the single-cell level. The Episode further explores Claire's findings on the XACT locus regulation, evolution from retroviruses, and its potential role in preventing X-chromosome silencing. Claire also shares her future research focus on understanding X-inactivation establishment in humans and the transition from XIST attenuating to silencing X-chromosomes after implantation.   References Makhlouf, M., Ouimette, J. F., Oldfield, A., Navarro, P., Neuillet, D., & Rougeulle, C. (2014). A prominent and conserved role for YY1 in Xist transcriptional activation. Nature communications, 5, 4878. https://doi.org/10.1038/ncomms5878 Vallot, C., Ouimette, J. F., Makhlouf, M., Féraud, O., Pontis, J., Côme, J., Martinat, C., Bennaceur-Griscelli, A., Lalande, M., & Rougeulle, C. (2015). Erosion of X Chromosome Inactivation in Human Pluripotent Cells Initiates with XACT Coating and Depends on a Specific Heterochromatin Landscape. Cell stem cell, 16(5), 533–546. https://doi.org/10.1016/j.stem.2015.03.016 Casanova, M., Moscatelli, M., Chauvière, L. É., Huret, C., Samson, J., Liyakat Ali, T. M., Rosspopoff, O., & Rougeulle, C. (2019). A primate-specific retroviral enhancer wires the XACT lncRNA into the core pluripotency network in humans. Nature communications, 10(1), 5652. https://doi.org/10.1038/s41467-019-13551-1   Related Episodes Epigenetics and X-Inactivation (Edith Heard) Investigating the Dynamics of Epigenetic Plasticity in Cancer with Single Cell Technologies (Céline Vallot)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

References Circ Res. 2018 Sep 14; 123(7): 868–885 Ungurianu, A., Manuela Drăgoi, C.,Crenguța,Nicolae, A., Dumitrescu,I.-B., Grădinaru, D.,& Margină, D.2024. IntechOpen. doi: 10.5772/intechopen.1003914 Blood Cancer J. 2024 Dec; 14(1): 24 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

Could a simple copper peptide be the key to youthful skin and better health?   In today's bonus episode of the Longevity podcast, I discuss GHK-Cu - the tiny, naturally occurring copper peptide that just may be the secret weapon you've been looking for in your quest for healthier, more youthful-looking skin and improved overall well-being.   I dive into this powerful compound and the research that shows GHK-Cu resets over 4,000 genes in the human body to a more youthful state. From wound healing and skin rejuvenation to potential applications in neurodegenerative diseases and even cancer treatment, the possibilities for GHK-Cu are truly mind-blowing. Overall, this episode will give you tips for incorporating it into your skincare routine and how it will revolutionize your skin health.  Thank you to our sponsors for making this episode possible: BiOptimizers: Go now to http://magbreakthrough.com/bionatfree and get your bottle of Magnesium Breakthrough for FREE today!   Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Join Nat's Membership Community: https://www.natniddam.com/bsp-community Sign up for Nats Newsletter: https://landing.mailerlite.com/webforms/landing/i7d5m0 Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance   What I discuss: 02:21 GHK Copper and Gene Expression 07:34 Bioavailability and Applications of GHK Copper 10:52 GHK Copper for Skin Health 16:10 GHK Copper and Nerve Regeneration Key Takeaways: GHK Copper is a naturally occurring peptide in our bodies that plays a central role in repair and regeneration. It affects over 4,000 genes in the human body, resetting them to a more youthful setting. GHK Copper has been shown to be beneficial for wound healing, skin health, hair growth, nerve regeneration, and even cancer treatment. It is bioavailable topically and possibly orally, making it accessible for various applications. GHK Copper can help mitigate sun damage and promote skin health. Further research and exploration of GHK Copper's potential benefits are warranted.  

In today's episode of the "Fasting for Life" podcast, we delve into the debate between the calorie in, calorie out model and the carbohydrate insulin model of obesity, focusing on a recent study involving obese mice. The study found that a low-carb, high-fat diet prevented the development of nonalcoholic fatty liver disease (NAFLD) more effectively than the Western diet, even under similar caloric conditions. We emphasize the significant role of macronutrients, insulin levels, and meal timing in weight management and overall health, urging listeners to combine fasting with low-carb diets for optimal results. We also encourage listeners to explore their resources for practical tips on implementing these strategies in their own lives. FREE RESOURCE - DOWNLOAD THE NEW BLUEPRINT TO FASTING FOR FAT LOSS! Learn how to RAMP UP into longer fasting windows! Gain insights into the non-weight loss benefits of fasting! Personalize your own fasting schedule and consistent FAT LOSS results! Get answers to what breaks a fast, how to break a fast, and tips and tricks to accelerate your fasting wins! THE BLUEPRINT TO FASTING FOR FAT LOSS DOWNLOAD Get your FREE BOX OF LMNT hydration support for the perfect electrolyte balance for your fasting lifestyle with your first purchase here! Get 30% off a Keto-Mojo blood glucose and ketone monitor (discount shown at checkout)! Click here! Let's continue the conversation. Click the link below to JOIN the Fasting For Life Community, a group of like-minded, new, and experienced fasters! The first two rules of fasting need not apply! Fasting For Life Community - Join HERE New to the podcast and wondering where to start? Head to the website and download our Fast Start Guide, 6 simple steps to put One Meal a Day Fasting (OMAD) into practice! Get our NEW sleep guide here! SLEEP GUIDE DIRECT DOWNLOAD If you enjoy the podcast, would you please tap on the stars below and consider leaving a short review on Apple Podcasts/iTunes? It takes less than 60 seconds, and it helps bring you the best original content each week. We also enjoy reading them! Research Links:

https://passionstruck.com/passion-struck-book/—Order a copy of my new book, "Passion Struck: Twelve Powerful Principles to Unlock Your Purpose and Ignite Your Most Intentional Life," today! The book was picked by the Next Big Idea Club as a must-read for 2024, the winner of the Business Business Minds Best Book 2024, and a finalist for the Eric Hoffer First Horizon Award for best debut novel.In this episode of Passion Struck, host John R. Miles interviews Dr. Michael Greger, a renowned physician and author who shares valuable insights on preventing diseases, improving health, and promoting longevity through lifestyle interventions. The episode covers a wide range of topics, including the impact of diet on heart disease, strategies for preserving bone health, tips for maintaining cognitive function and enhancing sexual health. Full show notes and resources can be found here:  https://passionstruck.com/dr-michael-greger-on-blueprint-for-healthy-aging/In this episode, you will learn:The importance of lifestyle interventions and promoting health and longevity based on his personal experience with his grandmother's recovery from heart disease.The impact of nutrition on preventing diseases like heart disease and cancer.Insights on the Mediterranean and Okinawan diets, emphasizing the benefits of whole plant foods for overall health.Strategies for preserving bone strength, cognitive health, and sexual function as part of an anti-aging approach.Xenohormesis and microRNA manipulation as potential mechanisms for improving health and longevity through plant-based diets and exercise.All things Dr. Michael Greger: https://nutritionfacts.org/SponsorsBrought to you by Indeed. Head to https://www.indeed.com/passionstruck, where you can receive a $75 credit to attract, interview, and hire in one place.Brought to you by Nom Nom: Go Right Now for 50% off your no-risk two week trial at https://trynom.com/passionstruck.Brought to you by Cozy Earth. Cozy Earth provided an exclusive offer for my listeners. 35% off site-wide when you use the code “PASSIONSTRUCK” at https://cozyearth.com/This episode is brought to you by BetterHelp. Give online therapy a try at https://www.betterhelp.com/PASSIONSTRUCK, and get on your way to being your best self.This episode is brought to you By Constant Contact:  Helping the Small Stand Tall. Just go to Constant Contact dot com right now. So get going, and start GROWING your business today with a free trial at Constant Contact dot com.--► For information about advertisers and promo codes, go to:https://passionstruck.com/deals/Catch More of Passion StruckWatch my interview with Dr. Lucia Aronica On The Impact Of Personalized Nutrition On EpigeneticsMy solo episode on how to heal from the consequences of abuseCan't miss my episode with Dr. Will Cole On How To Restore Your Gut-Feelings ConnectionListen to my interview with Dr. Kara Fitzgerald On How To Become A Younger You By Reversing Your Biological AgeMy solo episode on The Science Of Healthy HabitsCheck Out my episode with Dr. Mark Hyman On The Secrets To Living Young ForeverLike this show? Please leave us a review here-- even one sentence helps! Consider including your Twitter or Instagram handle so we can thank you personally!How to Connect with JohnConnect with John on Twitter at @John_RMiles and on Instagram at @john_R_Miles.Subscribe to our main YouTube Channel Here: https://www.youtube.com/c/JohnRMilesSubscribe to our YouTube Clips Channel: https://www.youtube.com/@passionstruckclips