Podcasts about Tissue

Dr. Vamsi Velcheti and Dr. Charu Aggarwal discuss the evolution of ctDNA as a critical tool in precision oncology and its implications for lung cancer management, including its potential role in the early-stage setting. TRANSCRIPT Dr. Vamsi Velcheti: Hello. I am Dr. Vamsi Velcheti, your guest host for the ASCO Daily News Podcast today. I am a professor of medicine and director of thoracic medical oncology at the Perlmutter Cancer Center at NYU Langone Health.  The management of small cell lung cancer has rapidly evolved over the past few decades, and today, molecular testing and biomarker testing for lung cancer are absolutely critical in terms of designing treatment options for our patients with metastatic non-small cell lung cancer. Today, I'm delighted to be joined by Dr. Charu Aggarwal for a discussion on ctDNA (circulating tumor DNA) and the role of ctDNA in lung cancer management. Dr. Aggarwal is the Leslye Heisler Professor of Lung Cancer Excellence and section chief of thoracic and head and neck oncology at University of Pennsylvania Abramson Cancer Center.  You'll find our full disclosures in the transcript of that episode.  Dr. Agrawal, it's great to have you on the podcast today. Thank you for being here. Dr. Charu Aggarwal: Thank you for having me. Dr. Vamsi Velcheti: Let's start off with setting the stage for ctDNA technology. These technologies have rapidly evolved from experimental conceptual stage to essential clinical tools for day-to-day clinical practice. Could you briefly discuss how recent advancements in ctDNA technologies are shaping our approach to precision medicine, especially in lung cancer? Dr. Charu Aggarwal: Absolutely. And you know, I think we need to just level set a little bit. What exactly is circulating tumor DNA? This is a way to assess exactly that. Every tumor sheds little pieces of tumor-derived DNA into the bloodstream, and this occurs in a variety of solid tumors. But now we have the technology to be able to derive this DNA that's actually being shed from the tumor into the bloodstream, these minute fragments of DNA, take them out, amplify them and sequence them with a variety of different mechanisms. They can be DNA sequencing alone, they can be DNA and RNA sequencing, they can be whole transcriptome sequencing. The technology, as you rightly pointed out, Dr. Velcheti, has significantly improved from just being able to look at circulating tumor DNA to now being able to amplify it, sequence it, and use it to offer personalized therapy. I think lung cancer is definitely the poster child for such an approach as we have a lot of data that has shown clinical utility and validity of being able to use circulating tumor DNA next-generation gene sequencing to guide therapy. Dr. Vamsi Velcheti: There have been so many technological leaps. It's really impressive how far we've come to advance these sequencing platforms. Recent advances with AI and machine learning are also playing important roles in interpreting ctDNA data. How are these computational advances really enhancing clinical decision-making in day-to-day clinical practice? Dr. Charu Aggarwal: I think while we have firmly established the role of ctDNA in the management of patients with metastatic lung cancer, some of the approaches that you talked about are still experimental. So let me backtrack a little bit and set the stage for how we use ctDNA in clinical practice right now. I think most patients, when they come in with a new diagnosis of stage IV lung cancer, we want to test for biomarkers. And this should actually be the established standard. Now included in the NCCN guidelines and actually also international guidelines, is to consider using blood-based testing or plasma-based testing to look for biomarkers, not just tissue-based testing which had been our historical standard, but to use these plasma guided approaches to identify the seven to nine biomarkers that may be truly implicated in either first- or second-line therapy that are called as your immediately actionable mutations.  What you're talking about is AI computational methods. I think there's a lot of excitement about how we can use genomic signatures that are derived from either tissue or ctDNA-based biomarker testing, combine it with radiomic features, combine it with histologic features, look at H & E patterns, use AI algorithmic learning to be able to actually predict recurrence scores, or can we actually come up with predictive signatures that may be extremely helpful?  So, I think some of the techniques and technologies that you're talking about are incoming. They are provocative. I think they're very exciting, but very early. Dr. Vamsi Velcheti: I think it's really amazing how many advances we have with these platforms. You know, the challenge really is the significant gap in terms of uptake of molecular testing. Even today, in 2025, there are significant gaps in terms of all metastatic lung cancer patients being tested for all biomarkers.  So, why do you think there's such a challenge in testing patients with lung cancer? In most academic practices, we try to achieve 100% testing for all our patients, but we know from recent studies that that's not the case across the country. What do you think the gaps are? Dr. Charu Aggarwal: Biomarker testing is so essential, like you pointed out, for us to be able to guide the right therapy for our patients. And we see this in our practice every day as you and I see patients with lung cancer, that a large proportion of our patients either don't get tested or they start therapy before their test results come back. So, I think this is a real problem.  However, to add some optimism to this problem, I do think that we are making a move in the right direction. So, four or five years ago, there was a lot of data being presented at national meetings, including ones from the American Society of Clinical Oncology, where we saw that, nationally, the rates of biomarker testing were probably in the rate of 40 to 50%. However, now with the availability of both tissue and plasma, I do think that the rates of biomarker testing are increasing. And if you were to survey a sample or even perform retrospective data research, I believe that the number is closer to 70% of all patients with metastatic non-small cell lung cancer.  And you know, you asked why is it not 100%? I think there are many reasons. I think the number one reason is tissue availability. Many times, the biopsies are small, or the tumor is very necrotic. So, either the tissue quantity itself is small, or the tissue quantity is insufficient to perform gene sequencing. And that's exactly where plasma comes in. When you don't have tissue availability, we have shown, as have others, that you can use plasma effectively to increase the proportion of patients who are not only tested but also receive the right therapy. I think there are also other barriers, including inertia. You know, I think this is both patient and physician inertia, where patients want to get started quickly, they don't want to wait. Physicians are very busy and sometimes want to be able to deliver treatment as soon as possible. We have seen there are some institutional barriers. Not every institution has in-house gene sequencing testing. So how do you really operationalize, send out these tests in a fast, efficient manner so that you get results back? Is it a pathologist who sends out the test? Is it the medical oncologist? Is it the pulmonologist or the interventionalist? I think there is this need to develop reflex testing mechanisms which some institutions do really well and some don't. And then finally, there are financial implications as well. How do we do this in a most cost-efficient fashion?  So there are many barriers, but I'm happy to say that we are making a move in the right direction as we are understanding that it's important to do it, it's easy to do it maybe with a value add of plasma, and finally, as you said, you know, as these technologies become more available, they're actually getting more cost-effective. Dr. Vamsi Velcheti: Dr. Aggarwal, you've been at the cutting edge of these advanced platforms and testing. So, what do you do in UPenn? How do you handle all these barriers and what is your workflow for patients in University of Pennsylvania? Dr. Charu Aggarwal: One of the things that I mentioned to you was there may be institutional barriers when it comes to gene sequencing. So, we actually, several years ago now, instituted a very robust reflex testing paradigm where almost all of our patients, regardless of stage, with a non-squamous non-small cell lung cancer diagnosis, would automatically be reflexively sent to our molecular pathology lab where they would get gene sequencing both for the DNA as well as with an RNA fusion-based platform. And the reason we did this was because we wanted to expedite and reduce the turnaround time. We also wanted to ensure that we were not just doing DNA testing, which I think is really important for our listeners here. There are many fusions as well as certain skipping mutations like MET exon 14 that may be missed on DNA testing alone. So, it's really incredibly important to run both DNA and RNA samples.  So, we do this routinely, and based on our research and others, what we also do routinely is that we send concurrent tissue and liquid biopsies or plasma MGS testing upon initial diagnosis. For example, if a patient comes in with a diagnosis of stage IV non-small cell lung cancer, their tissue might already be at my molecular pathology lab based on the reflex mechanism that I just described to you. But upon their initial meeting with me, we will send off plasma. And I will tell you this, that Penn is not just one institution, right? We have a large network of sites. And as part of my research, one of the things that we wanted to do was implement wide scale means to improve biomarker testing. And we have done this with the use of technology like you mentioned, Dr. Velcheti: How can we actually use AI? How can we leverage our electronic medical record to identify these patients? So, we have a nudge-based mechanism which actually facilitates the pending of orders for biomarker testing for patients with new diagnosis of metastatic non-small cell lung cancer. And we are looking at our rates of biomarker testing but also rates of completion of biomarker testing before first-line therapy started. So many of our participating sites are clusters for our randomized control trial to increase molecular testing. And I'm really excited about the fact that we're able to implement it not just at our main satellite, downtown Penn Hospital, but also across our community. Dr. Vamsi Velcheti: I think that's great. Thank you so much for those insights, Dr. Aggarwal. I think it's so important because having the best technology is just not enough. I think implementation science is actually a real thing. And I think we need to all learn from each other, advance these things.  So, I want to ask you about the new emerging paradigm in terms of using ctDNA. Of course, in the metastatic setting, we've been using ctDNA for molecular profiling for a while now. But the recent data around monitoring early-stage disease, especially post-operative monitoring, is an exciting area. There are a lot of opportunities there. Could you please talk us through the emerging data in lung cancer and how do we incorporate ctDNA-based monitoring MRD or should we even do that right now? Is the data ripe enough for us to kind of deploy this in a clinical setting? Dr. Charu Aggarwal: I think using ctDNA in the early-stage setting is our next frontier in lung cancer. I think naturally we have been able to successfully deploy this in the stage 4 setting. It made a meaningful difference in the lives of our patients, and we are a little bit behind the A ball in terms of how MRD is used in lung cancer. Because, you know, colorectal cancer has already done large-randomized trials based on ctDNA and MRD. It's routinely used in hematological malignancy. So, it makes sense that we should start to use it.  However, when I say this, I say this with excitement, but also a little bit of gentle caution saying that we actually don't quite have the prospective randomized data just yet on how to deploy. Yes, intuitively we would say that if you detect ctDNA and MRD, that patient is at higher risk. So, we identify that, but we actually don't know what to do with the second part of that information once you identify a patient with high risk. Are there other techniques that we can then come in with or other drugs that we can come in with to modify that risk? And that's the thing that I think we don't have right now. The other thing that we don't have right now is the timing of the assay, when to use it. Is it to be tested in the pre-op setting? Is the post-op test the best timing, or is it monitoring and dynamics of ctDNA that are most important? And the third thing I will say in terms of precautionary cause is that we don't know which test just yet. There are actually a few commercially available tests out in the market right now. We know about them and I'm sure our community colleagues know about them. Some of them even have Medicare approval. However, many of these tests are currently tissue informed. We don't have tissue uninformed tests. And what does that mean? Tissue uninformed means that you actually take a piece of tumor tissue, you sequence that tumor and based on the gene profile of that tumor, you actually design a panel that can then be used to track the mutations in the blood-based pack. This requires, as the name implies, a tumor. So can this be used in the pre-op setting is a large question. Because coming back to the idea of tissue availability, you and I both know that when we get FNAS and we use it for PDL-1 testing and we use it for gene sequencing, there often isn't enough tissue left for us to then either do whole genome sequencing or even whole transcriptome sequencing, which may be required to build some of these assays.  I think the future lies in this idea of tumor uninformed assays because if we could go to a blood only or a plasma only approach using novel signatures like proteomics or methylation, I think that's where the future is. But we're still a little bit early in the discovery stages of those, as well as to come are the validation stages so that we can be confident that these blood-only assays may actually give us an answer.  So, with those three cautionary notes, I would say that optimism is still very high. I think ctDNA MRD is the right place to think about. We need to do this for our patients to better identify high-risk patients and to think about means to escalate treatment for them. Dr. Vamsi Velcheti: Yeah, I completely agree, and I think with all the changes and evolution of treatments in the management of early-stage lung cancer now with neoadjuvant and adjuvant, there's really a need for an escalation and de-escalation of therapies post-operatively. And I think it's a huge opportunity. I think we all could learn from our colorectal colleagues. I think they've done a really good job at actually doing prospective trials in this setting. I think we're kind of a little behind here.  Dr. Charu Aggarwal: I think in the metastatic setting there are ongoing trials to look at this exact question. How do you choose an appropriate first-line therapy, a monitor ctDNA at the six-week trial? It's being evaluated in a trial called the “Shedders” trial, where if patients are still ctDNA positive at six weeks, then you can escalate treatment because they haven't “cleared” their ctDNA. There has been a lot of research that has shown that lack of ctDNA clearance in the metastatic setting may be a poor prognostic factor. We and others have shown that if you do clear your ctDNA or if you have a reduction in ctDNA load overall, that that is directly related to both an improved progression-free survival and overall survival. This has been shown with both tissue informed and uninformed assays. So I think it's very clear that yes, you can track it. I think the question is: Can you apply that data to the early-stage setting? And that's an open research question. A lot of groups are looking at that and I think it's completely reasonable, especially to determine duration of therapy, to determine optimal timing, optimal timing of scans even. And I think these are just such interesting questions that will be answered in the future. Dr. Vamsi Velcheti: And also like a kind of early detection of resistance patterns that might inform early initiation of combination strategies. And I think it's a lot of opportunities I think yet to be explored. A lot of exciting things to come and I'm sure we'll kind of see more and more data in the next few years.  Dr. Aggarwal, thank you so much for sharing your fantastic insights today on the ASCO Daily News Podcast. It's been a pleasure to have you on the podcast today. Hope to see you at ASCO. Dr. Charu Aggarwal: Thank you so much. This was great and I remain so excited by all of the possibilities to improve outcomes for our patients. Dr. Vamsi Velcheti: Thank you to all the listeners for your time today. If you value the insights that you hear from the ASCO Daily News Podcast, please take a moment to rate, review and subscribe wherever you get your podcast. Thank you so much. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity or therapy should not be construed as an ASCO endorsement. Follow today's speakers:  Dr. Vamsidhar Velcheti  @VamsiVelcheti  @vamsivelcheti.bsky.social Dr. Charu Aggarwal @CharuAggarwalMD   Follow ASCO on social media:  @ASCO on X (formerly Twitter)  ASCO on Bluesky ASCO on Facebook  ASCO on LinkedIn    Disclosures: Dr. Vamsidhar Velcheti:  Honoraria: Glavanize Therapeutics Consulting or Advisory Role: Bristol-Myers Squibb, Merck, AstraZeneca/MedImmune, GSK, Amgen, Taiho Oncology, Novocure, Takeda, Janssen Oncology, Picture Health, Regeneron Research Funding (Inst.): Genentech, Trovagene, Eisai, OncoPlex Diagnostics, Alkermes, NantOmics, Genoptix, Altor BioScience, Merck, Bristol-Myers Squibb, Atreca, Heat Biologics, Leap Therapeutics, RSIP Vision, GlaxoSmithKline  Dr. Charu Aggarwal: Consulting or Advisory Role: AstraZeneca, Daiichi Sankyo/AstraZeneca, Regeneron/Sanofi, Pfizer, Boehringer Ingelheim, Takeda, Arcus Biosciences, Gilead Sciences, Novocure, Abbvie Speakers' Bureau: AstraZeneca (an immediate family member) Research Funding (Inst): Merck Sharp & Dohme, AstraZeneca/MedImmune, Daiichi Sankyo/AstraZeneca, Lilly@Loxo, Candel Therapeutics  

Fascia has been a hot topic in both research and hands-on therapy for some time now. While the idea that massage therapists affect more than just muscle isn't new, defining exactly what "the other stuff" is has proven trickier than expected. Today, multiple definitions of fascia are debated worldwide. To bring clarity and foster better communication, a new, unified definition has been proposed in the Journal of Anatomy (January 2025). Join hosts Rachelle Clauson and Nicole Trombley, co-directors of AnatomySCAPES, as they dive into this fascinating, global discussion, sharing insights from their recent participation at the Winter School Research Conference in Padua, Italy, on this episode of The ABMP Podcast. Resources and Author Links: www.anatomyscapes.com/MATRIX for more information about “Journey Into the MATRIX: the Fascial System” dissection lab workshop! Curious about this new proposed definition of fascia? Check it out here in the Journal of Anatomy:  https://pubmed.ncbi.nlm.nih.gov/39814456/ Join AnatomySCAPES for their upcoming fascia-focused webinar Scar Tissue: A View Beneath the Surface. This webinar will take place on May 1 and you can register for this FREE on their website: website: www.anatomyscapes.com FB: facebook.com/AnatomySCAPES IG: instagram.com/anatomyscapes YouTube: youtube.com/@anatomyscapes   Hosts:   AnatomySCAPES Co-Directors, Rachelle Clauson and Nicole Trombley, are NCBTMB-approved continuing education providers and teach anatomy explorations for hands-on professionals online and in person. They co-author the “Anatomy for Touch” column in Massage & Bodywork magazine and enjoy helping therapists better understand how anatomy relates to what they are feeling through their sense of touch.   Nicole Trombley: As a massage educator, Nicole draws on her passion for human biology to help therapists better understand the tissues under their hands. She owns and operates Equilibrio Massage in San Diego, CA, where she has specialized in massage for pregnancy and postpartum for the past 20 years.   Rachelle Clauson: Rachelle loves teaching therapists about the structural organization and beauty of the human fascial system. She served as the Director of Creative and Administrative Affairs for the Fascial Net Plastination Project, and owns Flourish Bodywork, her private practice where she has offered hands-on bodywork in San Diego, CA, for the past 21 years.   Sponsors:   Anatomy Trains: www.anatomytrains.com     American Massage Conference: https://www.massagetherapymedia.com/conferences   Anatomy Trains is a global leader in online anatomy education and also provides in-classroom certification programs for structural integration in the US, Canada, Australia, Europe, Japan, and China, as well as fresh-tissue cadaver dissection labs and weekend courses. The work of Anatomy Trains originated with founder Tom Myers, who mapped the human body into 13 myofascial meridians in his original book, currently in its fourth edition and translated into 12 languages. The principles of Anatomy Trains are used by osteopaths, physical therapists, bodyworkers, massage therapists, personal trainers, yoga, Pilates, Gyrotonics, and other body-minded manual therapists and movement professionals. Anatomy Trains inspires these practitioners to work with holistic anatomy in treating system-wide patterns to provide improved client outcomes in terms of structure and function.                      Website: anatomytrains.com                        Email: info@anatomytrains.com             Facebook: facebook.com/AnatomyTrains                       Instagram: www.instagram.com/anatomytrainsofficial   YouTube: https://www.youtube.com/channel/UC2g6TOEFrX4b-CigknssKHA     American Massage Conference   Get ready to immerse yourself in the excitement as the American Massage Conference (AMC) arrives to Disney Springs near Orlando, Florida (May 16th-18th, 2025)! With a legacy of 17 successful years in Ontario, Canada, this premier event, proudly hosted by ONE Concept Conferences and expertly produced by Massage Therapy Media (MTM), boasts a lineup of presenters from across the nation and around the globe.   The American Massage Conference began in Atlanta in 2011 and has been hosted through the years in San Diego, Chicago, and Virginia Beach. The conference provides educational opportunities with engaging one-, two-, three- and four-hour class formats, networking opportunities, masterminds, MTM Talks, demonstrations, and an extensive exhibitor tradeshow.     Mark your calendars for an unforgettable experience filled with education, networking, and the celebration of massage therapy excellence! ABMP members receive a special discount to attend this in-person conference—log in to your ABMP account to access the discount code and register today.   Website: https://www.massagetherapymedia.com/conferences

Hey Friend, Have you ever walked out of the doctor's office with this phrase stuck in your head?

In this episode, I talked to Dr. Karolina Valente, CEO of Voxcell BioInnovation. Dr. Valente talks about how her company, Voxcell, is trying to revolutionize the drug development process by developing customizable 3D tissue models to test different therapeutics and drugs. We also talked about how AI will affect future drug trials, Vancouver's potential as a biotech hub, improvements needed to strengthen Canada's biotech industry, Voxcell's new and old products, and the difficulty of raising money to go to different rounds. ---------------------------------------------------------------Thanks to the sponsors:Audible: Use my link for a 30-day free trial: http://audibletrial.com/diamondgoatNewsly: https://newsly.mepromo code to receive a 1-month free premium subscription: EARLYMORNING Libysn: https://libsyn.compromo code: DG Dubby Energy: https://www.dubby.ggpromo code for 10% off: DIAMONDGOATOpus Clips:  https://www.opus.pro/?via=diamondgoat----------------------------------------------------------------------------------Listen on:Podcast website: https://www.spreaker.com/podcast/dg-early-morning-show--5943922Spotify: https://open.spotify.com/show/0EuhA6WyuerHtVAqcFrFeOPodcast YT channel clips: https://www.youtube.com/@dgearlymorningshowTiktok: @dgearlymorningshowApple Podcast: https://podcasts.apple.com/us/podcast/dg-early-morning-show/id1575451533Amazon Music: https://music.amazon.com/podcasts/f050b86c-1dad-4bc3-b12f-6aa5fa62438c  Goodpods: https://goodpods.com/podcasts/dg-early-morning-show-211830RadioPublic: https://radiopublic.com/dg-earlymorning-show-WoML4rBreaker: https://www.breaker.audio/dg-early-morning-showReason: https://reason.fm/podcast/dg-earlymorning-show--------------------------------------Check out my other stuff:Instagram: @itzdiamondgoatTwitter: @lildiamondgoatMain YT channel: youtube.com/diamondgoatTiktok: @lildiamondgoatSoundcloud: @Lil DiamondgoatSpotify: @Lil DiamondgoatMerch store: https://diamondgoat.creator-spring.com

Watch the video here: https://christianyordanov.com/tissue-salts-other-fun-stuff-brandon-thomas/ -------------Brandon Thomas, host of Expanding Reality, returns for another mind-expanding conversation! In this episode, we dive into the fascinating world of tissue salts—how they align with astrology, impact health, and keep us in balance with the natural world. Brandon shares insights on energy work, planetary transits, and the power of aligning with cosmic rhythms.Connect with Brandon:Website: https://www.expandingrealitypodcast.com/Expanding Reality Podcast: https://www.expandingrealitypodcast.com/copy-of-videoYouTube: https://www.youtube.com/channel/UCBrATGSZs2m-1-30_9VHPHwApple podcasts: https://podcasts.apple.com/us/podcast/expanding-reality/id1469846551 -------------Are you following health trends that actually harm your body? In my eye-opening masterclass "The 7 Popular But Deadly Health Fads," I reveal how common health practices promoted by influencers and gurus might be ravaging your gut, accelerating disease, and shaving years off your life.Discover which popular diets, supplements, and health rituals are secretly sabotaging your health and learn what to do instead. I explain why these seemingly healthy habits are damaging your body and provide actionable alternatives for true longevity.Register for free access to this essential health information at https://www.livelongerformula.com

A Kawerau paper mill has found a new power source as New Zealand struggles with a looming winter power crunch. A newly released briefing to the Minister shows electricity supply is tight, and gas supply needs to be maintained until suitable alternatives are found. Essity's Kawerau Paper Mill has become the first in the world to create a machine that runs entirely on geothermal steam. Essity General Manager Mark Stevens told Kerre Woodham that the main area of benefit is sustainability – with the mill producing the same amount of paper with 66% less carbon output. LISTEN ABOVE See omnystudio.com/listener for privacy information.

M: 5. E: 5.5.

There's growing concern about microplastics and how they impact our health...     And new research is showing something even more alarming—our brain tissue may contain 10 times more microplastics than any other organ!     These microscopic plastic particles are everywhere—in our food, water, and even the air we breathe.     So on today's Cabral Concept 3310, I'll take you through the latest research on microplastics, how they're affecting our brain and overall health, and most importantly, what we can do to reduce our exposure. Enjoy the show and let me know your thoughts!   - - - For Everything Mentioned In Today's Show: StephenCabral.com/3310 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!

The Stupid History of Tissue PaperBecome a supporter of this podcast: https://www.spreaker.com/podcast/the-stupid-history-minute--4965707/support.

It is difficult to put into words the impact that losing a parent has on a child, no matter what age you are.Twenty five year old Martha Lovett Cullen lost her beloved mum to breast cancer seven months ago, and she is now campaigning for more awareness of dense breast tissue reporting so that other women can be better informed about their health...Martha joins Seán to discuss.If you have any questions or worries, don't hesitate to contact breastcheck.ie by emailing info@breastcheck.ie or calling 1800 454555.

The 12 Schuessler Salts can be used to help the body balance itself. The 12 salts include calc flor, calc phos, calc sulph, kali mur, kali phos, kali sulph, nat phos, nat sulph, nat mur, ferr phos, mag phos and silicea (silica).  There are multiple applications of these homeopathic dilutions of 3x and 6x and of them the remedy mag phos for menstrual cramps, and the three remedies, ferr phos, kali mur nad kali sulph for mucous and phlegm of different colours is a staple in the knowledge shared with my patients. All views presented are based on credible sources, but they are explained through the individual's viewpoint.  Doing your own research while integrating new information is always important when forming your own viewpoint. The information in this podcast is not meant to address individual health needs, it is general in nature and should not be used as medical information for your health unless used in combination with your health practitioner.

It is difficult to put into words the impact that losing a parent has on a child, no matter what age you are.Twenty five year old Martha Lovett Cullen lost her beloved mum to breast cancer seven months ago, and she is now campaigning for more awareness of dense breast tissue reporting so that other women can be better informed about their health...Martha joins Seán to discuss.If you have any questions or worries, don't hesitate to contact breastcheck.ie by emailing info@breastcheck.ie or calling 1800 454555.

This episode of TTCL will feature an interview with Luis Santiago on La Mega. This monthly interview will inform the Spanish Community about Network For Hope and the incredible miracles that happen with Organ, Tissue, and Eye Donation. Resources: https://getoffthelist.org/ https://www.networkforhope.org/ https://www.networkforhope.org/about-us/ https://www.facebook.com/NetworkForHopeOPO https://aopo.org/

TWiP explains a study which finds that tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei, then remembers our departed colleague Dickson Despommier. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Click arrow to play Download TWiP #254 (88 MB .mp3, 61 minutes) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Tissue spaces are reservoirs of antigenic diversity for T. brucei (Nature) Understanding trypanosome antigenic variation (Emerg Top Life Sci) Tissue resident T. brucei (PLoS Path) Hero – Dickson Despommier Despommier Photo Art Parasitology Course (YouTube) Become a patron of TWiP  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees TWiP explains a study which finds that tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei, then remembers our departed colleague Dickson Despommier. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Tissue spaces are reservoirs of antigenic diversity for T. brucei (Nature) Understanding trypanosome antigenic variation (Emerg Top Life Sci) Tissue resident T. brucei (PLoS Path) Hero – Dickson Despommier Despommier Photo Art Parasitology Course (YouTube) Become a patron of TWiP  Send your questions and comments to twip@microbe.tv Music by Ronald Jenkees

Send us a textWhat if we could skip glass slides altogether and go straight from fresh tissue to digital image? Muse Microscopy's SmartPath device aims to do just that, capturing diagnostic-quality images directly from fresh tissue. In this episode brought to you by Muse Microscopy, I sit down with Dr. Rao and Dr. Edwards to discuss the insights, challenges, and future of this groundbreaking technology. We explore its regulatory ramifications, change management in veterinary and human pathology, and financial feasibility. Tune in to learn why SmartPath could be a game-changer for both pathologists and patients.00:00 Introduction to SmartPath Technology00:54 Meet the Experts: Dr. Rao and Dr. Edwards01:08 FDA Approval and Implementation Plans01:35 Change Management in Pathology01:56 Training Pathologists for SmartPath03:48 Translational Tissue Banking and Clinical Applications04:29 Impact on Breast Pathology05:49 Pathologists' Reception and Adoption14:33 Financial Viability and ROI19:44 Conclusion and Future ProspectsLinks and Resources:This episode on YouTubeMuse Microscopy WebsiteSmartPath Device Demo VideoSupport the showBecome a Digital Pathology Trailblazer get the "Digital Pathology 101" FREE E-book and join us!

In this episode of the Experience Miracles podcast, Dr. Tony Ebel discusses tongue ties from a perspective rarely addressed by other healthcare providers. While acknowledging that tongue and oral ties are real issues that can significantly impact breastfeeding, airway function, and development, Dr. Ebel explains why simply revising these ties often provides only temporary relief. He delves into the neurological root causes of tongue ties, describing them as compensatory mechanisms resulting from nervous system dysfunction. Dr. Ebel shares insights from his clinical experience about why addressing the underlying neurological issues through proper chiropractic care is essential for complete and lasting resolution of tongue tie symptoms and related challenges.[00:01:00] Introduction to Tongue TiesDefinition and terminology (oral ties, TOTs)Relevance for all ages, not just infantsConnection to broader health issues (sensory, airway, nervous system)[00:07:00] The Mechanical vs. Neurological UnderstandingWhy tongue ties are not just a mechanical issueComparison to ear tube surgeries and recurring problemsWhy improvements after revisions may be temporary[00:11:00] Four Myths About Tongue TiesMyth #1: It's just a mechanical problemMyth #2: Quick fixes work permanentlyMyth #3: If a baby has trouble latching, it's just a mouth issueMyth #4: It's just a nutritional deficiency/MTHFR issue[00:24:00] Understanding Subluxation and Its OriginsDefinition and origins of subluxationHow it can develop in-utero and during birthBirth interventions that commonly cause subluxationThe nerve connection to tongue function[00:29:00] The Solution ApproachNeurotonal adjustments explainedVagus nerve activation and nervous system regulationWhy a comprehensive approach is necessary[00:33:00] Whole-Body Connection and Working with PX DoctorsWhy children with tongue ties often have multiple issuesFinding a properly trained pediatric chiropractorEncouragement for parents seeking solutions-- Follow us on Socials: Instagram: @pxdocs Facebook: Dr. Tony Ebel & The PX Docs Network Youtube: The PX Docs For more information, visit PXDocs.com to read informative articles about the power of Neurologically-Focused Chiropractic Care. Find a PX Doc Office near me: PX DOCS DirectoryTo watch Dr. Tony's 30 min Perfect Storm Webinar: Click HereSubscribe, share, and stay tuned for more incredible episodes unpacking the power of Nervous System focused care for children!

Send Dr. Walrad Your ThoughtsAll Twelve Tissue Salt podcasts are available on Dr. Walrad's website: https://www.morningwithcaroline.com. Best to locate under the menu on the site.Silicae 6x is probably the most amazing tissue salt for it is necessary for bone creation and repair and makes the bone and connective tissue strong.  Silicea 6x is also known as the 'homeopathic knife'. It will pop out a splinter on the finger and foot with speed and ease. How about a cure for 'stinky feet'. There is more!  Enjoy Caroline's stories on Silicea 6x on today's podcast.Standard Process Whole Food Supplements, Organically Grown in the United States. "Changing lives since 1929"Order directly from Standard Process here:carolinewalrad.standardprocess.com/products

There's growing concern about microplastics and how they impact our health...     And new research is showing something even more alarming—our brain tissue may contain 10 times more microplastics than any other organ!     These microscopic plastic particles are everywhere—in our food, water, and even the air we breathe.     So on today's Cabral Concept 3310, I'll take you through the latest research on microplastics, how they're affecting our brain and overall health, and most importantly, what we can do to reduce our exposure. Enjoy the show and let me know your thoughts!   - - - For Everything Mentioned In Today's Show: StephenCabral.com/3310 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Another Weird Wednesday episode. Today we are reanimating life as scientists successfully revive brain tissue, and a 46,000-year-old worm comes back to the world of the living. Plus, we learn what mummies smelled like. On This Day in History, the Catholic Church bans Galileo from teaching his theory that the Earth rotates around the sun. Scientists Successfully Revived Brain Tissue from Suspended Animation | Popular Mechanics Mouse Brain Slices Were Frozen For A Week, Brought Back To Life | BroBible Frozen worm comes back to life after 46,000 years - Earth.com A worm has been revived after 46,000 years in the Siberian permafrost | CNN A novel nematode species from the Siberian permafrost shares adaptive mechanisms for cryptobiotic survival with C. elegans dauer larva | PLOS Genetics Ancient Egyptian mummies smell 'sweet' and 'spicy', researchers say | Offbeat News | Sky News What Does a Mummy Smell Like? Scientists Uncover Surprising Truth | SciTechDaily The truth about Galileo and his conflict with the Catholic Church | UCLA Contact the show - coolstuffcommute@gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, we explore the alarming development of lab-grown human brain tissue that is being harnessed to operate machinery, play video games, and potentially more. Researchers are pushing the boundaries of biotechnology by cultivating miniature, functional clusters of neurons capable of interfacing with external devices. We also delve into Orchestrated Objective Reduction (Orch-OR), a theory of consciousness proposing that self-awareness arises from quantum-level processes within neuronal microtubules. Together, these cutting-edge topics raise profound questions about the nature of intelligence, the ethics of creating and using living brain matter, and the very foundations of conscious experience.

Ann Lovatt joins Mary Greensmith to introduce her new ebook explaining more about using the tissue salts to rebalance your health. We deep dive into how the tissue salts evolved and we take a closer look at the kali (potassium) remedies. Ann explains about the characters of each of these remedies to help decipher between them when choosing a remedy. Visit Ann Lovatt's Website: https://www.annlovatt.com/ Ann Lovatt's Video Resources: https://www.annlovatt.com/videos-to-purchase Check out Homeopathy247 Specialist Teams: https://homeopathy247.com/professional-homeopaths-team/ Subscribe to our YouTube channel and be updated with our latest episodes. You can also subscribe to our podcast channels available on your favourite podcast listening app below: Apple Podcast: https://podcasts.apple.com/us/podcast/homeopathy247-podcast/id1628767810 Spotify: https://open.spotify.com/show/39rjXAReQ33hGceW1E50dk Follow us on our social media accounts: Facebook: https://www.facebook.com/homeopathy247 Instagram: https://www.instagram.com/homeopathy247 You can also visit our website at https://homeopathy247.com/

On University of Rochester Week: Can computers take over and put an end to animal testing? James McGrath, William R. Kenan, Jr. professor of biomedical engineering, examines this question Since 2001, James McGrath has been on the Biomedical Engineering faculty at the University of Rochester and served the department for over 10 years as the […]

Here is a PG-13 rated description of the National Institute of Health, Francis Collins, and human fetal tissue experimentation conducted over years. Why would a theistic evolutionist and an evangelical endorse the use of human fetal tissue for these experiments? Francis Collins definition of truth is neither biblical or scientific, yet he was heavily endorsed by evangelical ministries. This program includes: 1. The World View in 5 Minutes with Adam McManus (Modern-day Jonah story, 16 million Americans between 110 & 369 years old getting SSI checks?, British Prime Minister willing to put British troops in Ukraine) 2. Generations with Kevin Swanson

Here is a PG-13 rated description of the National Institute of Health, Francis Collins, and human fetal tissue experimentation conducted over years. Why would a theistic evolutionist and an evangelical endorse the use of human fetal tissue for these experiments? Francis Collins definition of truth is neither biblical or scientific, yet he was heavily endorsed by evangelical ministries.This program includes:1. The World View in 5 Minutes with Adam McManus (Modern-day Jonah story, 16 million Americans between 110 & 369 years old getting SSI checks?, British Prime Minister willing to put British troops in Ukraine)2. Generations with Kevin Swanson

A new MP3 sermon from Generations Radio is now available on SermonAudio with the following details: Title: Human Fetal Tissue Experimentation - Francis Collins and Evangelicalism Speaker: Kevin Swanson Broadcaster: Generations Radio Event: Radio Broadcast Date: 2/18/2025 Length: 34 min.

Today's guest are Darryl Reed and Charlotte Meli from Tissue Repair.Darryl brings a wealth of experience from roles across research, government, and the private sector, including multinational corporations and startups. After completing a melanoma research fellowship in Switzerland, he returned to Australia to work with the Therapeutic Goods Administration before taking on senior positions with Roche and Bayer. Now, as Chief Operating Officer at Tissue Repair Ltd, Darryl plays a pivotal role in the company's growth and ASX listing.Charlotte's journey in the cosmetic industry began over a decade ago. Starting as a Dermal Therapist, she advanced her education, earning a Bachelor of Nursing and specializing in cosmetic injectables. For the past seven years, Charlotte has honed her expertise, working alongside some of the most respected professionals in aesthetics. Together, Darryl and Charlotte bring a unique blend of pharmaceutical insight and clinical expertise to today's discussion.Here to skin healing and aftercare for aesthetic clinics from Tissue Repair, today we welcome Darryl Reed and Charlotte Meli.The ABIC Podcast is an independent podcast that operates with the support of our listeners (that's you!) So if you would like to support the show, we would very much appreciate that. Hit ‘subscribe' on Apple Podcastsor ‘follow' on Spotify, and leave a review if you're feeling especially generous and please follow us @aestheticbeautycouncil

Hey kids! This is a first for us here at ISR Radio! We have an hour long interview with my friend Gavi about her job in the field of tissue procurement! What is that? Well when you pass on and were nice enough to be an organ donor she is the one who removes your tissue, bones and organs for donations! What a wild job! We talk to her about what's involved, how she got into it and a ton of other stuff! I hope you like it and have a good time listening! I hope to have her on again soon so if you have any follow up questions hit me up! 

Seoul National University of Science and Technology Researchers Develop Bioink for Personalized Tissue Repair Using Kombucha SCOBY Nanocellulose. The bioink can be precisely applied directly onto damaged tissue with a digital biopen, offering a convenient solution for healing wounds. In a new breakthrough, researchers at Seoul National University of Science and Technology (SEOULTECH) have developed a novel bioink made from Kombucha SCOBY-derived nanocellulose, which provides a scaffold that supports cell growth for tissue repair. The bioink can be directly applied to the damaged areas through a handheld biopen, making it ideal for direct in vivo tissue engineering of wounds and complex defects, particularly in emergency and first-aid settings. Bioink for Personalised Tissue Repair Using Kombucha Tissue engineering utilizes 3D printing and bioink to grow human cells on scaffolds, creating replacements for damaged tissues like skin, cartilage, and even organs. A team of researchers led by Professor Insup Noh from Seoul National University of Science and Technology, Republic of Korea, has developed a bioink using nanocellulose derived from Kombucha SCOBY (Symbiotic Culture of Bacteria and Yeast) as the scaffold material. The biomaterial offers a sustainable alternative to conventional options, and it can be loaded onto a hand-held 'Biowork' biopen, also developed by the same team. The digital biopen allows the precise application of bioink to damaged defected areas, such as irregular cartilage and large skin wounds, paving the way for more personalized and effective in vivo tissue repair, eliminating the need for in vitro tissue engineering processes. This paper was made available online on 28 October 2024 and subsequently published in Volume 282, Part 3, of the International Journal of Biological Macromolecules on 1 December 2024. "Our prefabricated nanocellulose hydrogel network from symbiotic culture of bacteria and yeast has the potential to be used as a platform bioink for in vivo tissue engineering by loading all types of biomolecules and drugs and direct bioprinting," says Prof. Noh. Kombucha SCOBY is a symbiotic culture of bacteria and yeast used to ferment green tea. The microorganisms produce cellulose, which is biodegradable and compatible with cells. However, the nanocellulose derived from Kombucha SCOBY has an entangled structure, which requires modification for 3D bioprinting. This involves adjusting its rheological properties (how it flows) and mechanical properties to improve extrusion and maintain structural integrity after printing. The researchers accomplished this by partially hydrolyzing nanocellulose with acetic acid, breaking glucose bonds and disentangling the network for its bioprintablity. However, this treatment lacked control of its properties, leading to a reduction of its structural strength. The team reinforced the nanocellulose with chitosan (positively charged) and kaolin (negatively charged) nanoparticles. These chitosan and kaolin particles interact with cellulose through electrostatic forces, forming a stable hydrogel suitable for 3D bioprinting. The bioink was prepared by mixing the ingredients, including live cells, within a biopen. Digitally controlled, two counter-rotating screws within the biopen uniformly mixed the ingredients, creating a homogeneous bioink that could be directly applied through a needle onto damaged tissue. When attached to a 3D bioprinter, the biopen enabled the creation of multilayer, self-standing structures with high resolution, such as bifurcated tubes and pyramids exceeding 1 cm in height. The biopen was also used for direct in situ layer-by-layer printing of irregularly shaped defects. Using it, the researchers accurately filled 3D-printed cranium and femoral head molds with designed defects. The bioink and digital biopen combination offers a cost-effective solution for treating large areas and irregularly shaped wounds without any in vitro tissue regeneration ...

In this episode of the Pacey Performance Podcast, Rob speaks to Anthony Donskov about reflexive eccentrics. Reflexive eccentric training is gaining recognition for its role in improving athletic performance and reducing injury risk. In this episode, Anthony  breaks down the principles, programming, and practical applications of this training method, emphasizing the importance of stiffness, speed, and strategic progressions in athlete development. Anthony discusses how reflexive eccentrics involve rapid eccentric contractions that enhance force absorption and control. This method is especially relevant for high-level athletes, as it trains deceleration, stability, and explosive reacceleration—all key for sports like hockey. He highlights the importance of clear external cues, such as “grabbing the floor” or “being stiff,” to help athletes optimize landing mechanics and movement efficiency. The conversation also covers programming considerations, including off-season vs. in-season adaptations, how to balance heavy lifting with reflexive movements, and reducing muscle soreness while maximizing explosiveness. Anthony outlines a three-day cycle of training that incorporates heavy lifts, submaximal speed work, and strategic plyometrics. He stresses the need for individualized assessments, using player cards and radar graphs to track progress and adjust training accordingly. Despite the challenges in measuring reflexive eccentric adaptations, improvements in jump height, net impulse, and rate of force development suggest their effectiveness. He concludes by emphasizing the importance of structured strength, recovery, and flexibility in athlete programming, advocating for tissue remodeling and long-duration isometrics to reduce stiffness and chronic injury risk. This episode is packed with practical insights for coaches and practitioners looking to integrate reflexive eccentrics into their performance programs. Main talking points: • Reflexive eccentrics enhance speed, stiffness, and reacceleration • Rapid eccentric contractions improve force absorption and control • Training should be tailored to athlete experience levels • Clear external cues optimize movement efficiency and stiffness • Off-season training should focus on stiffness and strength • A three-day cycle balances heavy lifts and speed work • Reflexive eccentrics reduce muscle soreness and improve explosiveness • Tissue remodeling and isometrics help prevent chronic injuries

BUFFALO, NY—February 12, 2025 — A new #research paper was #published in Aging (Aging-US) on January 3, 2025, in Volume 17, Issue 1, titled “Characterization of DNA methylation clock algorithms applied to diverse tissue types.” Researchers Mark Richardson, Courtney Brandt, Niyati Jain, James L. Li, Kathryn Demanelis, Farzana Jasmine, Muhammad G. Kibriya, Lin Tong, and Brandon L. Pierce from the University of Chicago and University of Pittsburgh, studied how biological aging is measured using DNA. Their study found that while commonly used “DNA methylation clocks” work well for blood samples, they may be less reliable for other tissues like the lungs, colon, and kidneys. DNA methylation clocks are widely used in forensic science, epigenetics and longevity research to estimate a person's biological age based on chemical changes in DNA. These epigenetic clocks help scientists predict age-related diseases and assess how lifestyle factors, such as smoking, impact aging. Most were originally developed using blood samples, and their effectiveness in other tissues remains unclear. This study tested eight different DNA methylation clocks across nine human tissue types, including the lungs, prostate, ovaries, skeletal muscle, and kidneys. The researchers analyzed data from 973 tissue samples collected through the Genotype-Tissue Expression (GTEx) project. Their analysis revealed significant differences in biological age estimates across tissues. While blood samples provided the most reliable results, other tissues showed noticeable variations. For example, testis and ovary tissues appeared younger than expected, while lung and colon tissues appeared older. “These differences across tissue types were most apparent for clocks trained using DNAm from blood only (e.g., Hannum), but also present for clocks trained on multiple tissue types (e.g., Horvath, a clock designed for pan-tissue age prediction.” These findings suggest that aging may not occur at the same rate in every organ, and that standard DNA methylation clocks may not always give accurate biological age estimates outside of blood samples. The authors suggest that new, organ-specific epigenetic clocks may be needed to improve biological age prediction. Creating tissue-specific aging clocks could also improve medical diagnostics, age-related disease prevention, and health monitoring. The researchers emphasize that larger studies with more tissue-specific DNA methylation data are needed to refine these aging clocks. By improving these tools, scientists can better understand how aging affects different organs and develop more reliable methods for measuring biological age. These advancements could lead to better predictions of age-related diseases and new strategies for healthy aging. DOI - https://doi.org/10.18632/aging.206182 Corresponding author - Brandon L. Pierce - brandonpierce@uchicago.edu Video short - https://www.youtube.com/watch?v=Jz-daRsZO2o Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

This episode of TTCL will feature an interview with Julie Luebbers on La Mega. This monthly interview will inform the Spanish Community about Network For Hope and the incredible miracles that happen with Organ, Tissue, and Eye Donation. Resources: https://getoffthelist.org/ https://www.networkforhope.org/ https://www.networkforhope.org/about-us/ https://www.facebook.com/NetworkForHopeOPO https://aopo.org/

A recent study at the University of New Mexico has found that there could be a spoon's worth of microplastics in the human brain. The study found that the extent of the harm to human health is unclear, although an increased inflammation and risk of future adverse cardiovascular events is likely. Amani spoke to Dr Joel Rindelaub, Senior Lecturer of Chemical Sciences at the University of Auckland about the prevalence of microplastics in the human body, and what its impacts might be.  

Flush out the facts on toilet paper sustainability in this eye-opening episode of The Backyard Naturalists! As an award-winning podcast hosted by certified nature enthusiasts—including Master Naturalists and Wildlife Ambassadors—we're diving into the environmental impact of one of life's everyday essentials.   Join us as we break down the latest findings from the Natural Resources Defense Council's The Issue with Tissue report, which grades popular toilet paper brands based on their environmental impact. We'll explore the critical role of Canada's boreal forests, why recycled content matters, and how some major companies are still falling short when it comes to sustainability.   If you've never thought about what goes into your toilet paper, this episode just might change your perspective! Tune in for simple ways to make greener choices and learn how your purchasing decisions can help protect our forests for future generations.   If you have ideas for topics that you'd like us to pursue, send us a message either on our Facebook page or our website. We would really like to hear from you.   Connect with the Backyard Naturalists on the Web, Facebook and Instagram.   Please visit and support our presenting sponsor, Backyard Birds at http://www.thebirdfoodstore.com/. A mecca for bird lovers and bird watchers, Backyard Birds is an independent family-owned business located in Matthews, NC (next to Dairy Queen), just southeast of Charlotte.   Thanks for listening to The Backyard Naturalists.  We hope you have a day filled with the wonders of nature. Get outside and take a walk on the wild side! Please don't forget to leave a 5-star review for The Backyard Naturalists podcast.   Production services for The Backyard Naturalists podcast are provided by Downtown Podcasting. To start a conversation on how you can have a podcast, simply send an email to info@downtownpodcasting.com.

Send Dr. Walrad Your ThoughtsTISSUE SALTS 6X HELP OUR BODIES RUN SMOOTHY. The use of Tissue Salts on a need to  basis is determined by one's symptoms. Do you have watery bags under the eye, depression, head injuries, gas and other digestive issues, etc. Learn more from Caroline Walrad, PhD who has used tissue salts in practice for almost 30 years. Maybe the answer to not feeling well is one tissue salt away. https://www./morningwithcaroline.comFacial Diagnosis of Cell Salts by David CardOrder Catalyn with Iron from Standard Process where all the cell salts are found in the living organic food supplement. https://www.carolinewalrad.standardprocess.com/productsStandard Process Whole Food Supplements, Organically Grown in the United States. "Changing lives since 1929"Order directly from Standard Process here:carolinewalrad.standardprocess.com/products

Materials scientist and physicist Guosong Hong is an expert in getting materials to do remarkable things. Recently, he and collaborators used a common food dye found in snack chips to turn living tissue transparent, allowing light to penetrate through skin and muscle. Hong is now working to realize a new age of medical imaging that lets doctors see deep into the body – without surgery. It's a miracle of physics but it could change medicine, Hong tells host Russ Altman on this episode of Stanford Engineering's The Future of Everything podcast.Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your quest. You can send questions to thefutureofeverything@stanford.edu.Episode Reference Links:Stanford Profile: ​​Guosong HongGuosong's Lab: THE HONG LABConnect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces Guosong Hong, an expert in physics, material science, and biology from Stanford University.(00:02:52) Material Science Meets NeuroscienceHow Guosong's research blends nanomaterials and brain science.(00:04:01) Why Tissue Isn't TransparentThe challenge of light penetration in biological tissues.(00:05:55) A New Approach to Tissue ClearingThe physics behind tissue transparency and refractive index manipulation.(00:08:57) UV Light and TransparencyHow manipulating UV absorption can align refractive indexes.(00:11:17) First Experiments and ResultsInitial tests that demonstrate successful tissue clearing.(00:13:19) Applications in MedicineThe potential of transparent tissues in dermatology and medical imaging.(00:15:36) Testing on Live TissueThe results of testing transparency techniques on live mice.(00:19:30) Transparency in NatureHow some species have naturally transparent tissue.(00:20:52) Human Eye and Protein TransparencyThe unique proteins that keep our lenses clear using similar physics.(00:23:24) Wireless Light Inside the BodyThe development of ultrasound-activated light sources for tissue imaging.(00:26:56) Precision of Ultrasound LightHow precisely ultrasound can trigger tiny particles to emit light.(00:29:14) Conclusion Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook

ASMR Rustling and Crinkle Sounds (Shredded Tissue, Packing Peanuts)Advertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Audio reading from the July 2023 NSH Fixation on Histology Blog, Hot Dog as an Alternative Source for Control Tissue. Read entire article.

This week Sean Light joins us to discuss his start in comedy, accepting compliments, and hemorrhoids.

Send Dr. Walrad Your ThoughtsDo you experience symptoms like creamy yellow discharges, itching, candida, joint problems, insomnia and even gout? If you do, you will enjoy learning about Nat Phos 6x, a tissue salt which balances the acid conditions mostly from eating too much of the wrong choices. Dr. Walrad talks of what tissue salts are, foods Natrum Phosphoricum is found in and symptoms corresponding to acid conditions potentially balanced by this alkaline inorganic salt, Nat Phos 6x.Book: David Card, FACIAL DIAGNOSIS OF CELL SALTS.Enjoy Caroline Walrad's other podcasts of the other 11 Tissue SaltsCATALYN GF (gluten free) IS STANDARD PROCESS' ALL PURPOSE organic  VITAMIN FOR ALL YOUR TISSUE SALTS.  LEARN ABOUT and monthly order CATALYN HERE: https://carolinewalrad.standardprocess.com/products?page=1&searchTerm=Catalyn%C2%AE&sortOrder=relevancStandard Process Whole Food Supplements, Organically Grown in the United States. "Changing lives since 1929"Order directly from Standard Process here:carolinewalrad.standardprocess.com/products

Osteosarcoma Webinar Series: Alexander Davies, DVM, PhD joins us on OsteoBites to discuss his work which is focused on dynamic tumor-microenvironment signaling cross-talk, signal integration, and the development of 3D organotypic and tissue models to study these interactions using live-cell microscopy techniques. Results from studies in the Davies Lab demonstrate the utility of a novel dynamic live-cell tissue model, the lungSITE model, to quantitatively measure and understand tumor signaling dynamics and behaviors within the context of the lung metastatic niche. Data obtained from this model provided new insights into how spatial position and temporal response influence signaling dynamics, specifically in osteosarcoma lung metastasis, to create intratumoral signaling heterogeneity and consequent single-cell drug response variation. Dr. Alexander Davies graduated with a Ph.D. in Biochemistry and Molecular Biology and a D.V.M., with an interest in comparative oncology, from the University of California, Davis. He then completed a post-doctoral fellowship in cancer biology at Lawrence Berkeley National Laboratory before joining The Ohio State University as faculty in the Department of Veterinary Biosciences. While at OSU he was a member of the Comprehensive Cancer Center and faculty in the Cancer Biology and Cancer Engineering programs. Currently, Dr. Davies is an Assistant Professor at the Knight Cancer Institute within the Division of Oncological Sciences and Cancer Early Detection Advanced Research Center (CEDAR) where his work focuses on dynamic tumor-microenvironment signaling cross-talk, signal integration, and the development of 3D organotypic and tissue models to study these interactions using live-cell microscopy techniques.

Dr. Beckman's International Veterinary Dentistry Institute offers courses in all areas of vet dentistry.    Online & Live Courses for Vets and Techs https://veterinarydentistry.net/    To request an invitation to the VDP Program: https://ivdi.org/    Complications of Extractions or Oro-Nasal Fistula (ONF) Closure After Radiation in Humans and Dogs Introduction  Radiation therapy is a common treatment modality for certain cancers affecting the oral cavity in both humans and dogs. While effective for managing malignancies, radiation can lead to significant challenges in dental procedures, particularly tooth extractions and oro-nasal fistula (ONF) closures. This evaluation synthesizes literature discussing complications associated with these procedures in both species, highlighting parallels and species-specific differences.   Human Literature Osteoradionecrosis (ORN)  Pathophysiology: ORN is a major complication following extractions in irradiated fields. Radiation induces hypovascularity, hypocellularity, and fibrosis in the bone, reducing its ability to heal and resist infection. Incidence: Studies report ORN rates between 5% and 15% after dental extractions in irradiated patients. Risk Factors: Total radiation dose exceeding 60 Gy. Location: Mandible is more prone due to poorer vascular supply. Timing: Extractions performed within 6 months post-radiation have higher risks. Comorbidities: Diabetes, smoking, and poor oral hygiene exacerbate risks. Management: Prophylactic measures include hyperbaric oxygen therapy (HBOT). Surgical debridement or segmental resection may be necessary for severe ORN.  Soft Tissue Complications Delayed Healing: Radiation-induced fibrosis and reduced vascularity lead to delayed mucosal healing. Infections: Secondary infections, such as osteomyelitis, are common due to impaired immune response and reduced tissue integrity. Dehiscence: Closure of oro-nasal fistulas is often complicated by wound dehiscence due to tension at the suture site and poor healing capacity. ONF Closure Challenges: High recurrence rates due to radiation-induced tissue fragility. Limited availability of local tissue for flap reconstruction. Surgical Options: Use of pedicled flaps, such as buccal or palatal flaps, has been successful. Free tissue transfers (e.g., radial forearm free flap) are utilized for extensive defects. Tissue engineering with growth factors or stem cells is an emerging area of interest. Pre-Surgical Preparation: Hyperbaric Oxygen Therapy (HBOT): While not universally applied, HBOT is frequently recommended before surgical interventions in patients at high risk for ORN. Protocols often involve 20-30 preoperative dives (2.0-2.5 ATA for 90-120 minutes per session) and 10 postoperative dives. Antibiotics: Broad-spectrum antibiotics may be prescribed prophylactically to reduce the risk of infection. Nutritional Optimization: Ensuring the patient's nutritional status is optimized can improve surgical outcomes. Veterinary Literature (Dogs) Osteoradionecrosis (ORN)  Pathophysiology: Similar to humans, radiation in dogs leads to hypovascularity and reduced bone turnover. The mandible is the most commonly affected site. Incidence: Published reports indicate a lower incidence of ORN in dogs compared to humans, possibly due to differences in fractionation protocols and total radiation doses. Risk Factors: Total radiation dose (commonly > 50 Gy). Larger tumor burden and proximity to the bone. Management: Conservative treatment includes antibiotics and analgesics. Surgical intervention involves debridement or mandibulectomy in severe cases. Soft Tissue Complications Delayed Healing: Radiation reduces epithelial turnover and fibroblast activity, delaying healing of mucosal wounds. Fistula Formation: ONF formation is common after radiation and can be exacerbated by dental extractions, particularly in the caudal maxillary region. ONF Closure Challenges: Dogs often have limited tissue for local flap reconstruction. Radiation reduces the availability and viability of tissue for surgical manipulation. Surgical Options: Buccal mucosal advancement flaps and rotation flaps are commonly used. Palatal flaps are an alternative for larger defects. Advanced techniques, such as axial pattern flaps, have shown promise. Adjunctive Therapies: HBOT has been explored in veterinary medicine with anecdotal success, though systematic studies are limited.   Comparative Analysis Common Complications Delayed Healing: Both species exhibit delayed healing due to radiation-induced vascular and cellular changes. ORN: A significant risk in humans and dogs, although reported incidences and management strategies differ. Wound Dehiscence: Tissue fragility and tension at surgical sites are common across species.   Species-Specific Differences Risk Factors: Humans are more affected by lifestyle factors such as smoking and systemic conditions like diabetes. Dogs are less influenced by these factors but may have different radiation fractionation protocols affecting outcomes. Management: Free flap techniques and tissue engineering are more advanced in human medicine. Veterinary approaches often rely on local flaps and less invasive options due to cost and availability constraints.   Hyperbaric Oxygen Therapy (HBOT) Protocol Human Protocol  Hyperbaric oxygen therapy (HBOT) is commonly recommended presurgically for patients who have undergone radiation therapy, especially in the head and neck region, to reduce the risk of complications such as osteoradionecrosis (ORN) after oral surgery.   Typical HBOT Protocol for Pre-Surgical Cases: Presurgical Sessions: Number of Sessions: Usually 20-30 sessions. Duration of Each Session: Each session typically lasts 90 minutes at a pressure of 2.0 to 2.5 atmospheres absolute (ATA). Postsurgical Sessions: Additional 10-20 sessions may be recommended following the oral surgery to further promote healing and reduce the risk of complications. Scheduling: Presurgical HBOT is ideally started at least 3-4 weeks before the planned surgery to ensure adequate time to complete the prescribed sessions.   Why HBOT Helps: Increases oxygen delivery to tissues damaged by radiation. Promotes angiogenesis (growth of new blood vessels) in irradiated tissues. Enhances fibroblast function and collagen synthesis. Reduces infection risk by boosting tissue oxygen levels.   Important Notes: The specific number of sessions may vary depending on individual factors, such as the extent of prior radiation damage, the site of surgery, and the overall health of the patient. Close coordination between the oral surgeon, oncologist, and a hyperbaric medicine specialist is crucial for optimizing outcomes. Veterinary Protocol  The use of HBOT in dogs follows adapted protocols based on human medicine, with adjustments for size and species-specific factors. Presurgical Sessions: Number of Sessions: Typically 10-20 sessions are suggested. Duration of Each Session: Sessions last approximately 60-90 minutes at pressures of 1.5-2.0 atmospheres absolute (ATA). Postsurgical Sessions: Additional 5-10 sessions may be recommended depending on the dog's healing progress and surgical outcomes. Monitoring: Dogs should be carefully monitored for signs of oxygen toxicity or other adverse effects during HBOT. Sedation may be required for some patients. Future Directions Human Medicine: Further research into tissue engineering and stem cell therapies to improve healing. Optimization of prophylactic measures such as HBOT and pharmacologic agents. Veterinary Medicine: Development of standardized protocols for managing post-radiation complications, including recommendations for the use of hyperbaric oxygen therapy (HBOT) in veterinary medicine. Emerging guidelines suggest that HBOT can support pre-surgical preparation by improving tissue oxygenation, enhancing vascularization, and promoting healing. Typical protocols involve 10-20 sessions at 1.5-2.0 atmospheres absolute (ATA) for 60-90 minutes per session, with an additional 5-10 sessions postoperatively to ensure optimal healing. Further research is needed to validate these approaches and refine their application for specific conditions. Exploration of advanced reconstructive techniques and adjunctive therapies like HBOT in controlled studies. Cross-Species Insights: Comparative studies to assess shared pathophysiology and potential therapeutic strategies across species. Conclusion  Complications following extractions or ONF closures in irradiated fields pose significant challenges in both humans and dogs. While similarities in pathophysiology exist, differences in risk factors, management, and available interventions highlight the need for species-specific approaches. Continued research, particularly in cross-species translational medicine, is essential to improve outcomes for both populations.   Podcast Details Host: Dr. Brett Beckman, DVM, FAVD, DAVDC, DAAPM

Get 45% off the Magic Mind bundle with my link: https://www.magicmind.com/ALANBJAN #magicmind #mentalwealth #mentalperformance Alan interviews Evelyn Wilson. One morning, when Evelyn was taking her grandson to school, she had a runny nose, and she was throwing dirty tissues into the passenger seat. When she got home, she vowed to create a new invention to solve the dirty tissue issue.  Today, she's working to bring her new product to the market. Email: EvelynWilson8319@gmail.com  

A federal judge has indefinitely delayed a hearing over former Minneapolis police officer Derek Chauvin's effort to examine George Floyd's heart tissue. The Minneapolis Police Department this week welcomed the largest, most racially diverse incoming class of new hires to its department in more than five years. And North Dakota Attorney General Drew Wrigley says Fargo police officers were justified during an officer-involved fatal shooting in November. This is a MPR News morning update, hosted by Phil Picardi. Music by Gary Meister.Find these headlines and more at mprnews.org.Minneapolis Police Department welcomes largest class of new hires since George Floyd murderRead the latest edition of the Minnesota Today newsletter.Subscribe on Apple Podcasts, Spotify, YouTube or RSS.

Episode 215 Spotify Took down an Episode Day of the Kings - La Roscaa Will Trump pardon himself? Headlines Louisiana Tragedy and Vegas Explosion Canadian Prime Minister Justin Trudeau Resigns Zalensky on Friedman America the Enforcer! Chinese Health Officials Warning of new illness All the money is in lawsuits How do law firms work? If you have an Issue? I've got a Tissue Bitcoin at 101k What if my partner died? What will happen to the next round of adults? Mobile Home Parks Trash Stories Layoffs at Ross Warehouses

Please note the recording was before the new NASEM model was released. However, there is still a lot of good information from Dr. Weiss beyond those recommendations. This Real Science Exchange podcast episode was recorded during a webinar from Balchem's Real Science Lecture Series. You can find it at balchem.com/realscience.Most ration formulation software uses the 2001 NRC mineral equations. The basic concept of the 2001 NRC mineral requirements is to feed enough absorbable minerals to maintain adequate labile body stores and fluid concentrations. Minerals are lost each day via excretion in feces and urine, milk production, and incorporation into tissues or the fetus in the case of growing or pregnant animals. We have decent data to predict mineral concentrations of milk, growth, and the fetus; however, the endogenous loss in feces is much harder to capture. Absorption coefficients (AC) for most minerals are exceedingly difficult to measure. (0:29)The NRC requirements are the means of several experiments. Feeding to the mean results in half the cows being fed adequately or in excess, and half are not fed enough. In human nutrition, recommended daily allowances for vitamins and minerals are calculated as the mean plus two standard deviations, which statistically meets the requirement for 97% of the population. Since the standard deviation of the requirement is hard to acquire, human nutrition uses the same standard deviation for energy metabolism, around 20%. Dr. Weiss feels this is a reasonable safety factor for minerals for animals as well. He recommends feeding about 1.2 times the NRC requirement while keeping an eye on the maximum tolerable limit for the mineral in question. (4:59)How do we measure absorption? We measure the minerals in the diet, we apply AC, and we get grams or milligrams of absorbed minerals available for the animal to use. Dr. Weiss details some of the complex methodology involved in trying to obtain AC. Feces contain not only unabsorbed dietary minerals but also endogenous/metabolic minerals (e.g., intestinal cells, enzymes, etc.) and homeostatic excretion of minerals (e.g., dumping excess minerals). In the 2001 NRC, the endogenous fecal for almost every mineral is a function of body weight, which is incorrect. It should be a function of dry matter intake. (8:40)Endogenous fecal losses can also be measured using stable or radioactive isotopes. This method is extremely expensive and if radioactive isotopes are used, management of radioactive waste becomes an issue. Thus, most of the AC for trace minerals that used these methods are 50-60 years old. (15:33)Dr. Weiss details some of the issues with calcium requirements in the 2001 NRC leading to overestimation of calcium absorption for many calcium sources and overestimation of the maintenance requirement due to endogenous fecal being calculated using body weight. Organic and inorganic phosphorus have different AC, so partitioning between organic and inorganic will give a more accurate estimate of the requirement. (16:33)Potassium has a linear antagonistic effect on magnesium. You can feed more magnesium to overcome this antagonism, but you won't ever eliminate it. If you feed a few percent added fat as long-chain fatty acids, Dr. Weiss recommends feeding 10-20% more magnesium to account for soap formation in the rumen. (19:17)It's much more difficult to measure AC for trace minerals due to multiple antagonists, interactions among different minerals, and regulated absorption. In addition, AC for trace minerals is very low, which means a small change in the AC can have a huge impact on diet formulation. All feeds in the NRC system have the same AC for each trace mineral and we know that's not right.  (25:39)Dr. Weiss gives an overview of different trace mineral antagonisms and interactions and details his approach to formulation if he has absorption data for a particular ingredient. He also gives his estimates of revised AC for several minerals. (28:07)In summary, the factorial NRC approach only fits 50% of the population. Feeding an extra 10-20% above the NRC requirement includes about 97% of the population. We need to continue to account for more sources of variation in AC. Interactions need to be top of mind when considering mineral requirements and diet formulation. (37:39)Dr. Weiss takes a series of questions from the webinar audience. (40:50)Please subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table.  If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll mail you a shirt.

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The crossover content keeps on coming! Kevin and Zack welcome Mo back to talk about how to manage tissue for that beautiful crown prep you're doing!    They discuss various tissue management techniques crucial for successful crown prep appointments. They emphasize the importance of using cord, paste, and other tools to manage tissue effectively. They also touch upon the potential use of lasers, electrosurge units, and the controversial deep margin elevation technique. This is a comprehensive guide for dental students and dentists looking to enhance their tissue management skills!   Some links from the show: Safco Hemotrac Episode Index:  05:50 Tissue Management Techniques 19:00 Deep Margin Elevation and Biological Width Join the Very Dental Facebook group using the password "Timmerman," Hornbrook" or "McWethy," "Papa Randy" or "Lipscomb!" The Very Dental Podcast network is and will remain free to download. If you'd like to support the shows you love at Very Dental then show a little love to the people that support us! -- Crazy Dental has everything you need from cotton rolls to equipment and everything in between and the best prices you'll find anywhere! If you head over to verydentalpodcast.com/crazy and use coupon code “VERYDENTAL10” you'll get another 10% off your order! Go save yourself some money and support the show all at the same time! -- The Wonderist Agency is basically a one stop shop for marketing your practice and your brand. From logo redesign to a full service marketing plan, the folks at Wonderist have you covered! Go check them out at verydentalpodcast.com/wonderist! -- Enova Illumination makes the very best in loupes and headlights, including their new ergonomic angled prism loupes! They also distribute loupe mounted cameras and even the amazing line of Zumax microscopes! If you want to help out the podcast while upping your magnification and headlight game, you need to head over to verydentalpodcast.com/enova to see their whole line of products! -- CAD-Ray offers the best service on a wide variety of digital scanners, printers, mills and even  their very own browser based design software, Clinux! CAD-Ray has been a huge supporter of the Very Dental Podcast Network and I can tell you that you'll get no better service on everything digital dentistry than the folks from CAD-Ray. Go check them out at verydentalpodcast.com/CADRay!  

Introducing the All Def SquADD Cast show “Versus". It's a podcast with the OG SquADD! Each week, the SquADD will debate topics and vote at the end to see what wins. Versus airs every Monday and you can download and listen wherever podcasts are found. Special Guest Mike Damn Brandon Broady Roxxy Haze This Week We Discuss Run Out Of Tissue On Toilet vs Bring An Ugly Date To Thanksgiving Dinner Stuck On Island W/ Doctor vs Engineer  Have Every Law You've Broken Broadcasted vs Every Person You've Slept With  S/o To Our Sponsors Prize Picks Download Prize Picks Promo: SQUADD Mando Shopmando.com Promo: SQUADD

Hi :) Thank you for your opinions on the mic, I do appreciate them and have an idea whether this one will work or not thanks to you. :) I got a new lavalier/clip on mic by Audio Technica (this one: http://www.amazon.com/gp/product/B000ZLV77E/ref=as_li_tl?ie=UTF8&camp=1789&creative=390957&creativeASIN=B000ZLV77E&linkCode=as2&tag=wwwyoutub0e8c-20 ) to use in my tutorial/lesson videos and I hope this one will work better then my previous one. Can you hear a lot of hiss or rumble? :) Thank you for helping me out, I hope I made the right choice. ♥ In this video I'll be opening some packages/gifts that were sent by you guys (THANK YOU!) By this video I in no way am pressuring you to send me gifts, I appreciate them deeply though :) Enjoy my reactions to the gifts, they are not always relaxing though :P Make sure to check out the AMAZING BOOK ABOUT ASMR and our community "Idiot's Guides:ASMR", this is huge! : http://www.amazon.com/gp/product/1615648186/ref=as_li_tl?ie=UTF8&camp=1789&creative=390957&creativeASIN=1615648186&linkCode=as2&tag=wwwyoutub0e8c-20 Directory: 0-02:15- intro :) Hello ♥ can you hear me? how's the mic? :) 02:20-07:34 - first gift (beautiful hand made card with a charm leaf. Thank you! ) 07:35-15:15 - LOTS of tissue paper wrapped gifts :D I mean it's a tissue paper heaven! :D Thank you, sweetie! ♥ 15:17-18:33 - ASMR book, "Idiot's Guides:ASMR" !!! Thank you Ilse and Julie ♥ !!! Check it out please, its one of the first books about ASMR in print and it's very well done!! :D Lots of great information gathered by two beautiful ladies that are a part of our community! Make sure to get a copy: http://www.amazon.com/gp/product/1615648186/ref=as_li_tl?ie=UTF8&camp=1789&creative=390957&creativeASIN=1615648186&linkCode=as2&tag=wwwyoutub0e8c-20 Sorry I was falling asleep a bit to the pages sound at the end of it @_@ 18:34-21:54 - me being awkward (lol) because the package was not for me but for Ally ASMRrequests, I'll be sending it to her soon :) You have to see my face!! I am lost. It's a cute gesture, I just didn't expect it hehehe. :) 22:00-25:07 - cute Koala toy, and souvenirs from Australia :) Thank you, Maggie ♥ 25:08-end - me gushing from excitement of getting my first Bath Bombs :D I already used one and it was PARADISE! :D thank you! ♥ Products/equipment I used/worn in this video: Nailpolish: http://www.amazon.com/gp/product/B004KRV8MS/ref=as_li_tl?ie=UTF8&camp=1789&creative=390957&creativeASIN=B004KRV8MS&linkCode=as2&tag=wwwyoutub0e8c-20 Lipstick: http://www.amazon.com/gp/product/B004BCXAXW/ref=as_li_tl?ie=UTF8&camp=1789&creative=390957&creativeASIN=B004BCXAXW&linkCode=as2&tag=wwwyoutub0e8c-20 Mascara: http://www.amazon.com/gp/product/B00DF25VN6/ref=as_li_tl?ie=UTF8&camp=1789&creative=390957&creativeASIN=B00DF25VN6&linkCode=as2&tag=wwwyoutub0e8c-20 Foundation: http://www.amazon.com/gp/product/B00AYCOR7G/ref=as_li_tl?ie=UTF8&camp=1789&creative=390957&creativeASIN=B00AYCOR7G&linkCode=as2&tag=wwwyoutub0e8c-20 Concealer: http://www.amazon.com/gp/product/B00BM1WKT0/ref=as_li_tl?ie=UTF8&camp=1789&creative=390957&creativeASIN=B00BM1WKT0&linkCode=as2&tag=wwwyoutub0e8c-20 My binaural microphone is a set of 2 microphones : http://www.amazon.com/gp/product/B004BR20OM/ref=as_li_tl?ie=UTF8&camp=1789&creative=390957&creativeASIN=B004BR20OM&linkCode=as2&tag=wwwyoutub0e8c-20 2 microphone cables: http://www.amazon.com/gp/product/B0002E1P2Q/ref=as_li_tl?ie=UTF8&camp=1789&creative=390957&creativeASIN=B0002E1P2Q&linkCode=as2&tag=wwwyoutub0e8c-20 Recorder: http://www.amazon.com/gp/product/B00UK7G3UO/ref=as_li_tl?ie=UTF8&camp=1789&creative=390957&creativeASIN=B00UK7G3UO&linkCode=as2&tag=wwwyoutub0e8c-20 Camera: http://www.amazon.com/gp/product/B004H8FN8A/ref=as_li_tl?ie=UTF8&camp=1789&creative=390957&creativeASIN=B004H8FN8A&linkCode=as2&tag=wwwyoutub0e8c-20 #ASMR #GentleWhispering #relax 6/18/15 --- Support this podcast: https://podcasters.spotify.com/pod/show/maria-gentlewhispering/support

"Tissue tolerance" might be a hard term for the average runner to define. But it could also be how you prevent your next big running injury. Phil Batterson, PhD, is a former competitive runner with a background in human bioenergetics. As the founder of Critical Oxygen, he gives athletes and coaches knowledge, testing, and coaching to optimize their physiology and maximize endurance performance. We talk about: How pliability, range of motion, and mobility affect tissue tolerance The impact of shock on the body while running Approaching training with injury prevention in mind Strength training and plyometrics to build tissue tolerance The role of cross training in injury prevention and adaptations How proteins help runners stay strong, but many aren't eating enough of it Hill training as a tool to improve tissue tolerance Why you don't need to barefoot run Send this episode to your friend who's prone to running injuries so they can take action today. Links & Resources from the Show: Listen to How to Improve the 3 Running Thresholds (Z2, LT, and VO2 Max) to hear Phil on another Strength Running Podcast episode. Critical Oxygen website The Critical Oxygen Podcast Phil on Instagram Critical Oxygen on YouTube Injury prone? Grab our free injury prevention email series to structure training with injury prevention ideas built directly into your training program. Thank you DrinkLMNT! A big thanks to DrinkLMNT for their support of this episode! They make electrolyte drinks for athletes and low-carb folks with no sugar, artificial ingredients, or colors. They are offering a free gift with your purchase at DrinkLMNT. And this does NOT have to be your first purchase. You'll get a sample pack with every flavor so you can try them all before deciding what you like best.  DrinkLMNT's products have some of the highest sodium concentrations that you can find. Anybody who runs a lot knows that sodium, as well as other electrolytes like magnesium and potassium, are essential to our performance and how we feel throughout the day. If you're not familiar, LMNT is my favorite way to hydrate. They make electrolytes for athletes and low-carb folks with no Sugar, artificial ingredients, or colors. I'm now in the habit of giving away boxes of LMNT at group runs around Denver and Boulder and everyone loves this stuff. Boost your performance and your recovery with LMNT. They're the exclusive hydration partner to Team USA Weightlifting and quite a few professional baseball, hockey, and basketball teams are on regular subscriptions. So check out DrinkLMNT to get a free sampler pack and get your hydration optimized for the upcoming season. Thanks to Chafed & Cranky Coffee! If you know me personally or watch our YouTube videos, you know that I love caffeine and coffee in particular. We all know the performance benefits of caffeine at this point: it's the world's most studied drug and is the most effective, legal performance enhancing drug on the market for runners. If you're not supplementing with caffeine before and during your big races, you're missing out on faster finishing times. Chafed & Cranky is a quirky brand that I love. But despite the fun branding, it's a high quality product with a variety of organic, fair trade, and single origin roasts to choose from. Because I like to be on brand, I go for a light roast since it has a higher caffeine content and I grind the beans fresh for my personal French Press in the morning. Treat yourself to delicious, high quality, performance benefitting coffee with Chafed & Cranky. Use code JASON at checkout to save 15% at chafedandcranky.com.