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The school year is in full swing for most of the country. We want to remind you about your required 30-day transition IEP meeting if your child has transitioned to a new school or new program. If you haven't been offered this meeting, request it now for a check-in. Even without a transition, you can still request this meeting to get updates on your child's progress. Don't delay! Now is the time! Today's guest has her finger on the pulse of today's special education programs, support, and funding, and she's here to help us understand the current situation. Join us!Jennifer Coco has a background in law and a focused passion for advocating for kids with special needs and disabilities. After starting in the civil rights field, she joined the Southern Poverty Law Center as a special education attorney to tackle systemic challenges in providing equal access and opportunity at the intersection of disability and race. Currently, she serves as the interim executive director of The Center for Learner Equity. This national organization cares deeply about kids with disabilities having equal access to high-quality school choices and opportunity.Show Highlights:THIS moment matters! (“We are at a scary juncture.”)Is the infrastructure in place to follow through with the law?The federal government is not following through on the provisions of the IDEA.Understanding the gap between the provisions and implementation of the IDEASolutions for charter schools in serving kids with disabilities: resources, access, and system capacityJennifer's approach to championing and advocating for charter schoolsThe two biggest problems for charter schools with inclusive education are planning and design.Systemic problems affect us all!Key takeaways from Jennifer: “Don't abandon hope! We need to hold hands and demand better for our kids.”Get involved!Resources:Connect with Jennifer Coco: Website, Jennifer's LinkedIn, and CFLE LinkedIn.Contact us on social media or through our website for more information about the IEP Learning Center: www.inclusiveeducationproject.org.Thank you for listening!Don't forget to SUBSCRIBE to the show to receive every new episode delivered straight to your podcast player every Tuesday. If you enjoyed this episode and believe in our message, please help us get the word out about this podcast. Rate and review this show on Apple Podcasts, Pandora, Spotify, or wherever you get your podcasts. Your rating and review help other listeners find this show. Connect with us and reach out with any questions or concerns: Facebook, Instagram, X, IEP Website, and Email.
Listen and subscribe to Money Making Conversations on iHeartRadio, Apple Podcasts, Spotify, www.moneymakingconversations.com/subscribe/ or wherever you listen to podcasts. New Money Making Conversations episodes drop daily. I want to alert you, so you don’t miss out on expert analysis and insider perspectives from my guests who provide tips that can help you uplift the community, improve your financial planning, motivation, or advice on how to be a successful entrepreneur. Keep winning! Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Dr. Bisa Lewis.
Listen and subscribe to Money Making Conversations on iHeartRadio, Apple Podcasts, Spotify, www.moneymakingconversations.com/subscribe/ or wherever you listen to podcasts. New Money Making Conversations episodes drop daily. I want to alert you, so you don’t miss out on expert analysis and insider perspectives from my guests who provide tips that can help you uplift the community, improve your financial planning, motivation, or advice on how to be a successful entrepreneur. Keep winning! Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Dr. Bisa Lewis.
Listen and subscribe to Money Making Conversations on iHeartRadio, Apple Podcasts, Spotify, www.moneymakingconversations.com/subscribe/ or wherever you listen to podcasts. New Money Making Conversations episodes drop daily. I want to alert you, so you don’t miss out on expert analysis and insider perspectives from my guests who provide tips that can help you uplift the community, improve your financial planning, motivation, or advice on how to be a successful entrepreneur. Keep winning! Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Dr. Bisa Lewis.
Protest is the ultimate in equal-opportunity political action. As Annie Leonard, former executive director of Greenpeace USA says, “Making change is like laying a stone path across the garden. Peaceful protest may be every 4th or 8th or 200th stone; it helps us get where we want to go but also we need a lot of other stones too.” Leonard explores the history of protests in her book “Protest: Respect It. Defend It. Use It.” And while protest is the loudest and most visible tool, it's only one of many ways to take action. Through community building, civic engagement, elected office, corporate boardrooms, churches and nonprofit agencies, there are countless paths to exercising power and promoting positive change. In this episode we hear from three leaders working in three different arenas, all toward the same goal. Guests: Annie Leonard, Environmental Activist, Author of “Protest: Respect It, Defend It, Use It” Danielle Lee, Founder, Climate Action Club James Coleman, City Councilor, South San Francisco Highlights: 00:00 – Introduction 03:55 – Annie Leonard shares the story of the Section 504 sit-ins protest in San Francisco 06:30 – Different ways protest can be effective 08:30 – Leonard on why she puts her body on the line (gets arrested) during protests 16:00 – Leonard on the lawsuit Energy Transfer brought against Greenpeace USA over Standing Rock protests 22:00 – Protecting, defending, and using the right to protest 26:00 – Danielle Lee on organizing younger people around climate and environment 30:30 – Systemic versus personal action 37:00 – James Coleman on the decision to run for office as a tool for effective change 41:00 – Impact of local government 46:30 – How change actually happens For show notes and related links, visit our episode page at ClimateOne.org Join Climate One for a town hall event on September 28 at 6 p.m. on navigating AI, climate, and the future of democracy. How do we ensure that AI and data centers serve the public good? How does a democracy function when AI is distorting our sense of shared truths? Tickets available at climateone.org/events *** Also: We'll be having an electric conversation on October 14 at 6 p.m. between PG&E CEO Patti Poppe and California State Senator Scott Wiener about energy affordability, outages, and whether cities like San Francisco are ready to break up with the investor owned utility model. Tickets available at climateone.org/events *** Support Climate One by going ad-free! By subscribing to Climate One on Patreon, you'll receive exclusive access to all future episodes free of ads, opportunities to connect with fellow Climate One listeners, and access to the Climate One Discord. Sign up today. *** Ad sales by Multitude. Contact them for ad inquiries at multitude.productions/ads Learn more about your ad choices. Visit megaphone.fm/adchoices
In this episode, Eli is joined by Dr. Ben Caldwell, Dr. Sarah Lyon & Dr. Sofia Georgiadou for a conversation reflecting on the evolving landscape of MFT education, supervision, and training, exploring how programs can prepare emerging clinicians for the complexity, responsibility, and privilege of working with challenging client systems.
Protest is the ultimate in equal-opportunity political action. As Annie Leonard, former executive director of Greenpeace USA says, “Making change is like laying a stone path across the garden. Peaceful protest may be every 4th or 8th or 200th stone; it helps us get where we want to go but also we need a lot of other stones too.” Leonard explores the history of protests in her book “Protest: Respect It. Defend It. Use It.” And while protest is the loudest and most visible tool, it's only one of many ways to take action. Through community building, civic engagement, elected office, corporate boardrooms, churches and nonprofit agencies, there are countless paths to exercising power and promoting positive change. In this episode we hear from three leaders working in three different arenas, all toward the same goal. Guests: Annie Leonard, Environmental Activist, Author of “Protest: Respect It, Defend It, Use It” Danielle Lee, Founder, Climate Action Club James Coleman, City Councilor, South San Francisco Highlights: 00:00 – Introduction 03:55 – Annie Leonard shares the story of the Section 504 sit-ins protest in San Francisco 06:30 – Different ways protest can be effective 08:30 – Leonard on why she puts her body on the line (gets arrested) during protests 16:00 – Leonard on the lawsuit Energy Transfer brought against Greenpeace USA over Standing Rock protests 22:00 – Protecting, defending, and using the right to protest 26:00 – Danielle Lee on organizing younger people around climate and environment 30:30 – Systemic versus personal action 37:00 – James Coleman on the decision to run for office as a tool for effective change 41:00 – Impact of local government 46:30 – How change actually happens For show notes and related links, visit our episode page at ClimateOne.org *** Join Climate One for a town hall event on September 28 at 6 p.m. on navigating AI, climate, and the future of democracy. How do we ensure that AI and data centers serve the public good? How does a democracy function when AI is distorting our sense of shared truths? Tickets available at climateone.org/events *** Also: We'll be having an electric conversation on October 14 at 6 p.m. between PG&E CEO Patti Poppe and California State Senator Scott Wiener about energy affordability, outages, and whether cities like San Francisco are ready to break up with the investor owned utility model. Tickets available at climateone.org/events *** Support Climate One by going ad-free! By subscribing to Climate One on Patreon, you'll receive exclusive access to all future episodes free of ads, opportunities to connect with fellow Climate One listeners, and access to the Climate One Discord. Sign up today. *** Ad sales by Multitude. Contact them for ad inquiries at multitude.productions/ads Learn more about your ad choices. Visit megaphone.fm/adchoices
Can preterm birth be prevented? Historically the answer has been no, and the numbers back that up. In 2006 the U.S. preterm birth rate was about 12 percent. In 2024 it was 10.4 percent. Medicine has gotten dramatically better at keeping premature babies alive, but almost no better at keeping pregnancies from ending early. In this episode, Kristin and Dr. Abdelhak make the case that the answer is yes, preterm birth can be prevented far more often than it is now, and that the field has been looking in the wrong place. Preterm birth is not one condition. It is a grab bag: placental abruption, systemic infection like appendicitis or pyelonephritis, uterine overdistension from twins, triplets, or polyhydramnios, trauma, severe hypertension, stimulant and cocaine use. Every one of those causes announces itself. The woman with triplets is obviously carrying triplets. The woman with an abruption is bleeding and in pain. So what about the woman with none of that, doing everything right, who shows up at 30 weeks contracting and three centimeters dilated? For forty years the answer was "subclinical infection," a diagnosis Dr. Abdelhak takes apart in this episode. If it is subclinical, why is preterm labor the only clinical thing it ever does? Why does an appendicitis start with pain and fever and end in labor, while this mystery infection skips straight to the last step? And after four decades of amniocentesis studies cataloguing cytokines, interleukins, and prostaglandins, where is the treatment? There isn't one, because researchers found exactly what they went looking for. His answer is mechanical, not microbial. The cervix is a timekeeper on the pregnancy. Conventional teaching says contractions open the cervix. He argues it runs the other way: the cervix quietly gives way over weeks, and when it opens far enough, labor starts. That is why he says he is almost never surprised by a preterm labor. He was already watching the cervix shorten. Also covered: why previous preterm birth is the single strongest risk factor (it is the same cervix), why cone biopsy raises risk more than LEEP does, what funneling on ultrasound actually tells you, the difference between classic cervical insufficiency and the milder version that still lets you reach the third trimester, and why a three-hour precipitous labor at 38 weeks may be the same finding wearing a friendlier face. The practical takeaway: serial cervical length measurement for anyone with a red flag, first-time moms included, and cerclage when the cervix starts to open. Screening plus treatment, not a pill for an infection nobody can find. Plus: why the president and Taylor Swift would get their cervix measured every single week, and what that tells you about the standard of care the rest of us are offered. Topics covered, in order Why this topic is worth repeating, and why the framing here is not the conventional one The better question: preventing preterm birth, not preterm labor Fifty years, the March of Dimes, and a rate that has barely moved What we did get better at: neonatal survival and outcomes, not prevention Preterm birth as a grab bag, not a single disease Placental abruption Systemic infection: appendicitis, pyelonephritis, sepsis, severe pneumonia, COVID The subclinical infection theory, and the case against it Why the amniocentesis and cytokine studies found what they set out to find Uterine overdistension: twins, triplets, polyhydramnios Trauma, decidual hemorrhage Severe hypertension, pulsatile flow, and abruption risk before 20 weeks Cocaine, methamphetamine, smoking The patient nobody can explain, and what is actually going on The core claim: dilation causes the contractions, not the other way around Why Dr. Abdelhak is rarely surprised by a preterm labor Mild cervical insufficiency, and "dreamlike" cervical insufficiency at 38 weeks Why previous preterm birth is the number one risk factor LEEP versus cone biopsy, and why cone matters more Normal variation in cervical length, and the big nose analogy Length is not everything: bulk, thickness, and how the cervix feels Funneling on ultrasound as a warning sign The proposal: serial cervical length screening plus cerclage Why the numbers are U.S. numbers, and why international rates are not trustworthy The VIP standard of care, and who actually gets weekly scans Key takeaways Preterm birth is not one condition. Abruption, systemic infection, overdistension, trauma, and severe hypertension each have their own mechanism, and each is usually obvious on arrival. "Subclinical infection" is not a diagnosis, it is a placeholder. Forty years in, it has produced no treatment and no measurable drop in the preterm birth rate. The cervix is the timekeeper. When it is weak, it opens slowly over weeks, and labor follows the opening rather than causing it. Previous preterm birth predicts the next one because it is the same cervix. You cannot order a new one. Cone biopsy raises preterm birth risk more than LEEP, because more cervix is removed. Length is a clue, not a verdict. Plenty of women have naturally short cervixes and carry to term. Funneling, bulk, and change over time matter as much as a single number. The intervention that would move the needle already exists. Serial cervical length measurement in anyone with a risk factor, and cerclage when it starts to open. Screening and treatment, not a mystery pill. Terms mentioned Placental abruption — the placenta separating from the uterine wall before delivery. Pyelonephritis — kidney infection. Polyhydramnios — too much amniotic fluid. Uterine overdistension — the uterus stretched beyond its comfortable capacity, as with twins or triplets. Cervical insufficiency — a cervix that opens without labor. Funneling — the cervix opening from the inside out, visible on ultrasound before any external change. Cerclage — a stitch placed to reinforce the cervix. LEEP and cone biopsy — procedures removing cervical tissue after abnormal Pap or HPV findings. Precipitous labor — a very fast labor, often under three hours. Memorable quotes: "I am telling you what happened was the three centimeters dilated caused the contractions." "If it's subclinical, why doesn't it stay that way?" "The cervix is a mechanical timekeeper on the pregnancy." Got something you want to share or ask? Keep it coming. We love hearing from you. Email us or send a voice memo, and you might just hear it on the next episode. Don't forget to like, comment, and subscribe your questions could be featured in our next episode. For additional resources and information, be sure to visit our website at Maternal Resources: https://www.maternalresources.org/ You can also connect with us on our social channels to stay up-to-date with the latest news, episodes, and community engagement: YouTube: youtube.com/maternalresources Instagram: @maternalresources Facebook: facebook.com/IntegrativeOB TikTok: NatureBack Doc on TikTok Grab Our Book: The NatureBack Method for Birth—your guide to an empowered pregnancy and delivery. Shop now at naturebackbook.myshopify.com
Show SummaryOn today's episode, we're having a conversation with Military Intelligence and Civil Affairs Veteran Rebecca Monaco, co-founder of Next Mission, an organization dedicated to empowering and supporting resettled Afghan women veterans who served alongside U.S. Special Operations forcesEpisode Partner:Our sponsor this week is Aetna, a trusted health care company, committed to serving Veterans, military families, and caregivers through meaningful, community-centered care. Provide FeedbackAs a dedicated member of the audience, we would like to hear from you. If you PsychArmor has helped you learn, grow, and support those who've served and those who care for them, we would appreciate hearing your story. Please follow this link to share how PsychArmor has helped you in your service journey Share PsychArmor StoriesAbout Today's GuestRebecca Monaco, MPH, is a public health leader, researcher, and program strategist with more than ten years of experience leading complex initiatives across healthcare, nonprofit, government, and military organizations. She earned her Master of Public Health from Dartmouth College, where she developed a passion for behavioral health research, implementation science, and innovative approaches to improving care. Her current interests focus on psychedelic-assisted therapy, women's health, and translating emerging research into real-world impact.A former U.S. Army Civil Affairs and Intelligence Officer, Rebecca deployed to Afghanistan as a Cultural Support Team (CST) member with Joint Special Operations Command, where she served alongside Afghan Female Tactical Platoon (FTP) members. Following the fall of Afghanistan, her team coordinated the evacuation of 42 Afghan female Special Operations personnel, an experience that continues to shape her commitment to service, leadership, and advancing opportunities for vulnerable communities.Rebecca currently serves as the volunteer Project Manager and Board Secretary for NXT Mission, where she leads initiatives supporting refugee resettlement, education, workforce development, and long-term integration for displaced Afghan women and families across the United States.Links Mentioned During the EpisodeNext Mission WebsiteNext Mission on LinkedInPsychArmor Resource of the WeekThis week's PsychArmor Resource of the Week is a previous episode of the Behind The Mission podcast, episode 184 with Kari McDonough. Kari is Vice President of Welcome.US and Senior Advisor to the Welcome Fund, a program of Welcome.us that provides a source for grantmaking to organizations as they involve community members to welcoming coalition allies coming to the US as part of resettlement efforts. You can find the resource here: https://psycharmor.org/podcast/kari-mcdonough Contact Us and Join Us on Social Media Email PsychArmorPsychArmor on XPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families. You can find more about the work that he is doing at www.veteranmentalhealth.com
Our minds have been carefully groomed to accept the imperial status quo as normal and healthy, and to see every failure of the system as a failure of the individual. Reading by Tim Foley.
To order Suicidal Empathy: https://lnk.to/SuicidalEmpathy To order a signed copy of Suicidal Empathy: https://premierecollectibles.com/suicidalempathy _______________________________________ If you appreciate my work and would like to support it: https://subscribestar.com/the-saad-truth https://patreon.com/GadSaad https://paypal.me/GadSaad To subscribe to my exclusive content on X, please visit my bio at https://x.com/GadSaad _______________________________________ This clip was posted on August 15, 2026 on my YouTube channel as THE SAAD TRUTH_2066: https://youtu.be/N2aiCUgDVGo _______________________________________ Please visit my website gadsaad.com, and sign up for alerts. If you appreciate my content, click on the "Support My Work" button. I count on my fans to support my efforts. You can donate via Patreon, PayPal, and/or SubscribeStar. _______________________________________ Dr. Gad Saad is a professor, evolutionary behavioral scientist, and author who pioneered the use of evolutionary psychology in marketing and consumer behavior. In addition to his scientific work, Dr. Saad is a leading public intellectual who often writes and speaks about idea pathogens that are destroying logic, science, reason, and common sense. _______________________________________
Show SummaryAs military-connected students head back to school, we're revisiting a conversation with Mary Bier, MBA, President and CEO of the Military Child Education Coalition (MCEC). Mary joins host Duane France to discuss the unique educational experiences of military-connected children, the challenges families can face navigating school transitions, and how MCEC helps families, educators, and communities support military students throughout their educational journey.Episode Partner:Our sponsor this week is Aetna, a trusted health care company, committed to serving Veterans, military families, and caregivers through meaningful, community-centered care. Provide FeedbackAs a dedicated member of the audience, we would like to hear from you. If you PsychArmor has helped you learn, grow, and support those who've served and those who care for them, we would appreciate hearing your story. Please follow this link to share how PsychArmor has helped you in your service journey Share PsychArmor StoriesAbout Today's GuestMary Bier, MBA, is the President and Chief Executive Officer of the Military Child Education Coalition (MCEC). A seasoned leader with more than 20 years of experience in business strategy, organizational leadership, and community engagement, she brings a dynamic vision to MCEC's mission of ensuring every military-connected child has access to quality educational opportunities.As a military spouse and parent, Bier has firsthand insight into the unique challenges and strengths of military families. This lived experience fuels her passion for advocating for military-connected students, ensuring they receive the educational support and opportunities they deserve.Bier's professional background spans both the corporate and nonprofit sectors, where she has successfully led high-impact initiatives, built collaborative partnerships, and served as a subject matter expert on veteran and military family issues. She has been invited to the White House to share insights on military-connected programs, testified before the New York City Department of Veteran Affairs, and facilitated expert panels on military family well-being.Prior to joining MCEC, Bier held leadership roles in business strategy, customer success, and military initiatives, where she was instrumental in scaling operations, optimizing talent development, and fostering inclusive organizational cultures. Her ability to translate strategic goals into actionable outcomes has driven mission impact across multiple organizations.At MCEC, Bier is committed to expanding the organization's reach, deepening partnerships, and championing the needs of military-connected children. Under her leadership, MCEC will continue to be a trusted resource for families, educators, and policymakers dedicated to supporting military students on their educational journey.Bier holds a Master of Business Administration (MBA) with a focus on Management and Organizational Behavior and a Bachelor of Arts in Spanish from California Lutheran University.She resides with her family in Madison, Wisconsin.Links Mentioned During the EpisodeMilitary Child Education Coalition Website Heroic Hearts ScholarshipCall for the Arts ScholarshipMonth of the Military Child ToolkitPurple Star National AdvocateStudent to Student ProgramPsychArmor Resource of the WeekThis week's resource of the week is the PsychArmor course, Supporting Children Who Support Veterans. Although your children may be small now, we hope this course gives you some building blocks to address any parenting challenges you may encounter as your children mature.You can find the resource here: https://learn.psycharmor.org/courses/Supporting-Children-Who-Support-Veterans Contact Us and Join Us on Social Media Email PsychArmorPsychArmor on XPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families. You can find more about the work that he is doing at www.veteranmentalhealth.com
In this episode, Dr. Christina Prevett discusses the impact of ageism in healthcare, especially when working with older adults. She explores how healthcare providers' perceptions influence patient care and highlights real-world examples of systemic issues and biases. 00:00 Introduction and birthday reflection 00:29 Study on ageism among healthcare providers 00:59 How working with older adults influences perceptions 01:28 Impact of ageism on healthcare system 02:27 Vulnerable moments in older adult care 03:19 Heterogeneity of aging trajectories 04:15 Selection bias in patient populations 05:12 Traveling older adults and healthcare representation 05:40 Case example: Masters athletes and pickleball 07:06 Unintentional skewing of perceptions 08:02 Consequences of ageism in healthcare 08:29 Dismissal of symptoms and misdiagnosis 09:27 Mental health and aging stereotypes 10:51 Patronizing communication and elder speak 12:16 Under-treatment and rationing of care 13:09 Preventative care and health promotion 14:32 Systemic issues and healthcare incentives 16:03 Case study: 75-year-old with fecal impaction 17:23 Fragmented care and systemic neglect 18:49 Systemic bias and patient neglect 20:27Closing remarks and reflection on practice
Patrick McKenzie (patio11) is joined by Manish Goregaokar, a senior software engineer and member of the Rust security response team, to discuss what LLMs do to the cost side of running a sophisticated con. They walk through a scam built for programmers: a plausible company, a few rounds of interviews, and an NDA signed via "sign in with email" that quietly hands an attacker the identity account everything else resets against. A version of it hit at least five people in the Rust community within days of Manish publishing on the subject, and Patrick describes being targeted himself by someone posing as a Bloomberg reporter who wanted him on a Zoom call with a codec problem. They also cover money mules and the three stages of laundering, the $25 million Hong Kong transfer authorized on a fully deepfaked video call, and why the only durable individual defense is refusing to trust any communication you did not initiate.–Full transcript available here: https://www.complexsystemspodcast.com/what-llms-do-to-the-economics-of-scams-with-manish-goregaokar/ –Presenting Sponsors: Mercury, MongoDB & GranolaComplex Systems is presented by Mercury—radically better banking for founders. Mercury's new feature Command brings an LLM directly into your banking interface, so checking balances, finding invoices, or sending a wire is as easy as asking. Apply online in minutes at https://mercury.com/. If meetings consistently leave you with hazy action items and lost context, Granola handles the transcription so you can actually participate and gives you searchable notes afterward. Try it free at granola.ai/complexsystems with code COMPLEXSYSTEMSWhat's the point of building faster with AI if your database can't keep up? MongoDB's native data model mirrors the language LLMs already speak. Ship at the speed of AI while staying ACID compliant at Fortune 500 scale. Start building at https://mongodb.com/ai.–Links:Manish Goregaokar's blog: https://manishearth.github.io/ Manish on X: https://x.com/ManishEarth–Timestamps:(00:00) Intro(00:27) The future of the con is already here(01:40) Scams are run like businesses(03:30) A scam aimed at programmers(05:12) Why single sign-on is the one ring to rule them all(06:50) Persistent threats against individuals(08:58) What LLMs change about cost(11:40) Manual scams and business email compromise(14:30) How money movement constrains scammers(17:39) The industry that helps you pay ransoms(19:32) Bespoke attacks on individual targets(21:41) The Rust community gets targeted(23:02) Supply chain attacks and long-lived impersonation(24:58) Money mules and the three stages of laundering(28:35) Why law enforcement struggles with internet crime(30:01) Sponsors: Mercury │ Granola(33:03) Patriotic hackers and the post-Soviet talent pool(35:27) What individuals can do(36:27) Only trust communication you initiate(38:21) Wire fraud in real estate closings(41:07) Why legitimate institutions look like scams(45:22) Who eats the loss(47:21) Sponsor: MongoDB(48:12) Why banks can't just block new payees(50:45) Verification protocols and family passwords(53:07) Urgency and secrecy(54:44) Systemic fixes and who pays(57:55) Open weights and the coming wave(01:02:17) Wrap
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In this explainer episode, we've asked Dr Antonio D'Alessio, Medical Oncologist at Guys and St Thomas Foundation Trust, to explain cancer vaccines and how they work. You can also find a series of short videos explaining some of the common terms you might encounter about genomics on our YouTube channel. If you've got any questions, or have any other topics you'd like us to explain, let us know on podcast@genomicsengland.co.uk. You can download the transcript or read it below. Florence: What are cancer vaccines and how do they work? My name is Florence Cornish, and today I'm joined by Antonio D'Alessio, who is a medical oncologist ay Guy's and St Thomas' Foundation Trust and King's College. And he's going to be telling us much more about the topic. So Antonio, before we get into cancer vaccines, I wanted to first ask you about cancer. I know it's a pretty broad term, and it refers to the uncontrolled growth of cells in the body, but maybe it would be helpful for you to explain a little bit more about what cancer actually is, like what that term means, especially for listeners out there who might not have that scientific background. Antonio: Yeah, of course. And first of all, thanks for inviting me today. Well, that's a big question. The point is that we know that in our bodies there are billions of cells, and all of these cells, they divide, they do their job, and they know when to die on schedule. The point is that sometimes there are cells that ignore this instruction and just keep reproducing and growing, and this is when cancer grows. Our bodies have systems, which is the immune system, to recognize when this happens so that the immune system can recognize the cancer cells that are growing too much. They attack them and destroy them. But unfortunately, sometimes cancer is quite clever, they manage to escape from the immune system and starts growing without control, and that's when cancer starts. Florence: And so, what are the standard treatments that we use for cancer at the moment? Antonio: Well, broadly speaking, I would say that we have three types of cancer treatments. One, it's surgery, where we just cut the cancer out. Then we have radiotherapy, where we basically induce targeted damage to the cancer. And then we have a very broad umbrella term that is systemic therapy. Systemic therapies can be chemotherapy, can be targeted therapies, and that can be immunotherapy. In particular, immunotherapy is quite exciting because over the past 20 years, we have learned how to boost the immune system of patients, so that's the white blood cells, the immune system of patients that can recognize cancer cells and attack them. Sort of imagine that cancers hide behind an invisibility cloak, and immunotherapy helps unveil the cancer so that the immune system can recognize the cancer again and attack it. And vaccines and cancer vaccines are part of this family of immunotherapy drugs. Florence: Yeah so speaking about that, I think lots of listeners might have heard of the term cancer vaccine before, obviously, its the topic of this episode. And I think the term cancer vaccine sounds very interesting and promising, but also maybe a little bit intimidating as well. So maybe you could tell me more about what a cancer vaccine is kind of at the most basic level. Antonio: Well, cancer vaccine is a vaccine, and we have received so many vaccines in our lives that our body basically has learnt already how to process a vaccine. Imagine a vaccine as a wanted poster. So, we give the body the instructions to recognise something that shouldn't be there, and the immune system knows how to do it. So, the job of the immune system is to recognize strangers in our bodies - that can be microbes, bacteria, viruses, and also cancers. And sometimes with a vaccine, we sort of help the immune system to do its job a bit better. And with vaccines, we provide the instructions to recognize these strangers in our body and help the immune system to, to get rid of them. And in particular, for cancer vaccines, we have different types of cancer vaccines. There's a family of cancer vaccines that are called preventative, where we can try to give a vaccine even before the cancer develops to reduce the risk that the cancer develops. And, this is more early in the development. While we have, another family of cancer vaccine, which are mostly mRNA cancer vaccines that are called therapeutic. So these are cancer vaccines that are given to patients who already have cancer, maybe who had the surgery for their cancers, so that the aim of the cancer vaccine is to boost immune system and reduce the chances that the cancer comes back after surgery, or, help other types of immunotherapy work better together with vaccine against the cancer. Florence: So, I think for me at Genomics England, the mRNA cancer vaccines are probably most relevant to the work that we do here as an organization. Could you explain a little bit more about how those ones work specifically? Antonio: Yeah, that's an exciting field, right? The mRNA vaccine. So, let's split this into different words, mRNA and vaccine. We have just covered what vaccine means. We just have to think mRNA as just instructions. So we give the body of the patients the instruction to recognize the cancer. And the mRNA is basically the instruction for the immune system to recognize some of the proteins that are expressed on the cancer cells, so that's the white blood cells, the own white blood cells of the patients that can be more alert and identify the cancer cells if they are around. And in particular, imagine when we give the mRNA vaccine, it's like we are giving the picture of a suspect to the police, right? The police is the immune system of the patients, and the suspect is the cancer. And so, the immune system, so the police of our body, can go around the body, can go around the bloodstream, can go around the organs, and if they see the suspect, they are, they are already alerted, and they can tackle it, attack it, and destroy it before it develops into, into a cancer that can be seen on the scans. Florence: And are these types or other types of cancer vaccines being used in the clinic at all in real medical settings already? Antonio: Well, I wouldn't say that we are using that in clinical practice, but probably in the future we will, and we are working hard to make sure that we will be able to use cancer vaccine for our patients. At this stage, we are using cancer vaccines as part of clinical trials, and these clinical trials cover different types of cancer types, different types of setting, together with other drugs or given alone after surgery, for instance. And the NHS England, Genomics England and NIHR, they launched this massive infrastructure that is called the Cancer Vaccine Launchpad. And it is aimed specifically to match the NHS cancer patients with personalized mRNA vaccine trials, so that once we have the results of those trials and we are ready to deploy it in clinical practice, then we already have the infrastructure to do that promptly, hopefully in the next future. Florence: Mm-hmm. Yeah, so do you see a future where cancer vaccines are used in routine care? Antonio: Well, we are working towards that. And I, and I do see a future where we're going to use that. I don't know when. Probably it will take still a few years. But the, for example, in the UK and in England in particular, we have a national cancer plan, and the national cancer plan for this year has identified cancer vaccine as a top priority for our health system. And this is because this is a technology that can be scalable, that can be widely deployed once it's demonstrated to be working. And at this stage, there are still some open questions, like which cancer types in which setting, which patients would benefit from it. But once we address these open questions in clinical trials, then I do believe that we'll be able to use that in the, in the future. Florence: I think we'll finish there. Thank you so much, Antonio, for coming on and for taking the time to talk to us. Antonio: Thank you Florence, and thank you for the invite. Florence: If listeners want to hear more explainer episodes like this, you can find them on our website at www.genomicsengland.co.uk or wherever you get your podcasts. Thank you for listening.
A #Research paper recently #Published in Volume 18 of Aging, titled “Slowing intervertebral disc aging in mice through long-term systemic treatment with the senolytic BCL-2/BCL-xL proteolysis targeting chimera (PROTAC) 753b,” examines whether the senolytic PROTAC 753b can slow age-related intervertebral disc degeneration (IDD) in mice. Long-term systemic treatment with 753b reduced key features of disc degeneration in 22-month-old male mice, including matrix breakdown, loss of disc aggrecan, age-related structural changes, and inflammatory markers such as IL-6 and TNFα. These benefits, however, were not observed in female mice, highlighting potential sex-based differences in the role of cellular senescence in IDD and the response to senolytic therapies. DOI - https://doi.org/10.18632/aging.206394 Corresponding author - Nam Viet Vo - nvv1@pitt.edu Abstract video - https://www.youtube.com/watch?v=t0z4MULDr1A Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206394 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, intervertebral disc aging, cellular senescence, senolytic, anti-apoptosis, PROTAC-753b To learn more about the journal, please visit https://www.Aging-US.com and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
Dr. Emily Matheson dives deep into the hidden “gender tax” that female athletes pay and why the sport system is unintentionally building their resilience.She reveals how traditional resilience measures miss the relational strengths women bring to sport and shares actionable strategies for athletes, coaches, and entrepreneurs to foster genuine mental‑health support.Listeners will walk away with fresh perspectives on measuring resilience, practical tools for building it, and a roadmap for creating more equitable athletic environments.Traditional resilience scales often overlook relational and gender‑specific factors; consider a more holistic assessment.Female athletes develop “relational resilience” by leaning on self‑awareness, community, and supportive networks.Systemic changes—like equitable scheduling and resource allocation—can reduce the hidden gender tax in sports.Coaches and leaders should shift from “forcing resilience” to co‑creating environments that nurture it.Entrepreneurs can apply these insights to build inclusive, high‑performing teams that value mental health as a core asset.Emily Matheson, PhD is a sport psychologist and research strategist specializing in mental health, body image, and resilience among female athletes. Currently leads research strategy at Great Minds and collaborates with brands such as Dove and Nike.https://dremilymatheson.com - Related research on resilience and gender in sportIf you found this conversation valuable, hit subscribe so you never miss an episode, leave a review to help us reach more listeners, and follow us on social media for behind‑the‑scenes insights. Got a topic you'd like us to explore? Drop us a note at the email above—we love hearing from entrepreneurs and small‑business owners looking to champion mental‑health in their teams.FeistyFest Info: https://livefeisty.com/events/feisty-fest/Register for FeistyFit: https://livefeisty.com/training/running/feistyfitfall/Courses and Coaching: https://livefeisty.com/courses/Women's Mechanic Camp in Tucson: https://livefeisty.com/events/bike-mechanic-school-tucson/Sign up to Receive The Feisty Women's Performance Newsletter:Feisty Women's Performance Newsletter: https://livefeisty.com/newsletters/feisty-womens-performance/Follow us on Instagram:@feisty_womens_performanceSupport our Partners:Momentous: Head to https://www.livemomentous.com/ and use promo code PERFORMANCE for up to 35% off your first orderWahoo: Learn more about Wahoo Fitness Products at: https://wahoofitness.pxf.io/0GAByRTifosi Optics: Use code FEISTY2026 for 20% off at https://tifosioptics.com/Hettas: Use code STAYFEISTY for 20% off at https://hettas.com/ Orca: Use the code FEISTY15 for 15% off at https://orca.avln.me/c/HzUkzIfxsmYo
In this deeply moving episode of Locating the Lost, we sit down with Miranda, the mother of young Ronnell "Prince" Jones Jr., to shine a light on a heartbreaking tragedy that should have been prevented.When Prince vanished, Miranda turned to law enforcement for help—only to encounter a web of red tape, missed warnings, and devastating delays. Despite early reports and a traffic stop detainment in 2025, critical systemic breakdowns allowed key opportunities for intervention to slip away. As Miranda begged to be heard, we were one of the only ones who listened. What You'll Hear in This EpisodeMiranda's Heartbreaking Account: Hear directly from Prince's mother about her relentless fight to find her son, the initial red flags, and her agonizing search for answers.Systemic & Procedural Failures: A closer look at the timeline of events—from early missing child reports in 2024 to how suspect Ronnell Jones Sr. was detained on a wanted status in early 2025 yet walked away without charges.Demanding Accountability: An examination of the internal affairs review into how law enforcement handled the case and why judicial and police protocol reforms are urgently needed.Honoring Prince: Remembering the bright, joyful spirit of Prince and understanding how Miranda is converting her profound grief into a plea for justice and child safety awareness."Prince was a joyful little boy who deserved protection, urgency, and answers. We refuse to let his voice be forgotten."Listen, Share & SupportIf Prince's story touches you, please subscribe, rate, and share this episode of Locating the Lost. Spreading this conversation helps amplify Miranda's voice, demands accountability from the justice system, and supports families fighting for missing loved ones.#LocatingTheLost #RonnellPrinceJones #JusticeForPrince #TrueCrimePodcast #MissingChild #SystemicFailures #PoliceAccountability #JusticeForPrinceJones #TrueCrimeCommunity #MissingAndUnsolved #MotherInGrief #ChildSafety #TrueCrimeStories #PodcastEpisode #AmmendsAndJustice #BringAwareness
In this new episode on The Gritty Nurse Podcast with Amie Archibald-Varley, we examine the case of Lindsay Clancy through the lens of postpartum psychosis and the catastrophic gaps in mental health care that allowed it to go unrecognized and untreated. I start with the question that should be asked before every postpartum antidepressant prescription: has this patient been screened for bipolar disorder? It's now considered the gold standard of care — and it only became standard practice because of this case. From there, we talk about what early screening should look like more broadly, what coordinated care between obstetric and psychiatric providers actually requires, and why compassion — not judgment — has to be the starting point if we want to prevent the next tragedy instead of just mourning it. If you're here for sensationalism, this isn't the episode for you. These are real people, a real family, and real suffering. Our purpose is not to relitigate what happened, but to ask why it happened, and what needs to change so it doesn't happen again. This is the conversation healthcare needs to be having — about postpartum psychosis, about the mothers falling through the cracks, and about the systemic changes required to catch them before it's too late. keywords postpartum psychosis, mental health, systemic failure, screening, care coordination, maternal health, psychiatric emergency, postpartum depression, bipolar disorder, healthcare gaps key topics Postpartum psychosis and its symptoms System failures in mental health care and prescription practices Importance of early screening for bipolar disorder and depression Systematic gaps in postpartum care and follow-up The Lindsay Clancy case and systemic accountability Role of healthcare providers in recognizing red flags Need for coordinated care among multiple prescribers Impact of medication polypharmacy and withdrawal Advocacy for improved postpartum mental health protocols Community and systemic responsibility in preventing tragedies * Listen on Apple Podcasts – : The Gritty Nurse Podcast on Apple Apple Podcasts https://podcasts.apple.com/ca/podcast/the-gritty-nurse/id1493290782 * Watch on YouTube – https://www.youtube.com/@thegrittynursepodcast Stay Connected: Website: grittynurse.com Instagram: @grittynursepod TikTok: @thegrittynursepodcast Facebook: https://www.facebook.com/profile.php?id=100064212216482 X (Twitter): @GrittyNurse Collaborations & Inquiries: For sponsorship opportunities or to book Amie for speaking engagements, visit: grittynurse.com/contact
NOTUS reporter Jenny Gathright joined WAMU to discuss what the D.C. Inspector General called a "systemic breakdown" in MPD's crime data systems.
Low libido in women is often blamed on stress, aging, or relationship problems, but changes in desire may begin years before menopause and can involve hormones, medications, pain, sleep, blood flow, and the difference between spontaneous and responsive desire. Dr. Natalie Crawford sits down with board-certified urologist Dr. Kelly Casperson, author of “You Are Not Broken” and “The Menopause Moment,” to explain why women may stop wanting sex, how testosterone and estrogen affect sexual health, and what to discuss with a clinician when something feels different. They also examine birth control and SSRI side effects, hormone therapy, vaginal estrogen, and why women's sexual health deserves greater attention. IN THIS EPISODE: 00:00 Why Women Can Lose Desire Before Menopause 02:10 Can Your Hormones Change While You Still Have a Period? 03:38 Why Testosterone Matters in Women 05:41 Can Birth Control Lower Your Libido? 08:04 How Estrogen Affects Desire, Arousal, and Vaginal Health 10:02 What Does Low Libido Actually Mean? 10:56 When Low Libido Is Really Painful Sex 13:15 Spontaneous vs. Responsive Desire 15:25 Are You Having Sex Worth Desiring? 16:53 What Causes Arousal Problems in Women? 17:20 How SSRIs Can Affect Sexual Function 17:50 How Couples Can Navigate Mismatched Sex Drives 21:05 Why Perimenopause Can Make You Feel Unlike Yourself 21:24 How Sleep, Estrogen, and Progesterone Affect Desire 21:50 Testosterone's Role in the Brain, Mood, and Motivation 24:40 How Is Testosterone Prescribed to Women? 27:15 What Happens When Testosterone Is Too High? 30:30 Can Testosterone Affect More Than Libido? 32:00 Testosterone, Wound Healing, and Bone Health 33:25 Could Testosterone Support Hip-Fracture Recovery? 34:00 Can Hormone Therapy Still Help Women Over 60? 36:00 Systemic vs. Vaginal Estrogen 37:00 Why Hormone Treatment May Begin Before Menopause 39:55 Can You Get Pregnant During Perimenopause? 41:41 When Vaginal Estrogen May Help 46:12 How to Talk to Your Doctor About Hormones 48:25 Where to Find Dr. Kelly Casperson GUEST RESOURCES:Website: https://kellycaspersonmd.comInstagram: https://www.instagram.com/kellycaspersonmdPodcast: https://kellycaspersonmd.com/you-are-not-broken-podcastYou Are Not Broken: https://kellycaspersonmd.com/you-are-not-broken-bookThe Menopause Moment: https://kellycaspersonmd.com/the-menopause-moment-book AS A WOMAN WITH DR. NATALIE CRAWFORD: YouTube: https://youtube.com/playlist?list=PLveZDgg3_HZ9m7Wy3C6Vvyrj_NtEOwj_l Apple Podcasts: https://podcasts.apple.com/us/podcast/as-a-woman/id1449553339 Spotify: https://open.spotify.com/show/12IYOLH9liu60gk5D0bRPk HOST RESOURCES: Order The Fertility Formula: https://www.nataliecrawfordmd.com/book Newsletter: https://www.nataliecrawfordmd.com/newsletter Instagram: https://www.instagram.com/nataliecrawfordmd YouTube: https://www.youtube.com/@NatalieCrawfordMD Become a patient: https://www.forafertility.com Earn FREE CE/CME: https://learnatpinnacle.com/education This episode is brought to you by The Pinnacle Podcast Network. ABOUT DR. NATALIE CRAWFORD: Natalie Crawford, MD, is a double board-certified OB/GYN and reproductive endocrinologist, co-founder of Fora Fertility, and author of The Fertility Formula. She helps women understand their hormones, fertility, and reproductive health so they can make informed decisions about their bodies. Disclaimer: Natalie Crawford, MD, is a doctor, but she is not your doctor. This content is for general education and is not a substitute for individualized medical care. Learn more about your ad choices. Visit megaphone.fm/adchoices
Show SummaryOn today's episode, we're having a conversation with Military and Veteran Spouse Stephanie Rundle, founder of Bridge and Banner, an organization that provides support for learning continuity for children who move frequently, which includes active duty military families. Episode Partner:Our sponsor this week is Aetna, a trusted health care company, committed to serving Veterans, military families, and caregivers through meaningful, community-centered care. Provide FeedbackAs a dedicated member of the audience, we would like to hear from you. If you PsychArmor has helped you learn, grow, and support those who've served and those who care for them, we would appreciate hearing your story. Please follow this link to share how PsychArmor has helped you in your service journey Share PsychArmor StoriesAbout Today's GuestStephanie Rundle is an educator, military spouse, and military child advocate whose experience was built in classrooms across the country, serving as a teacher, instructional coach, and leader. Stephanie began her role in education upon earning her degree in Birth through Kindergarten Education from Western Carolina University. Within the walls of formal education, she created unique learning experiences that embraced the diverse learning needs of her students, preschool through fourth grade. While teaching, she earned a Master of Curriculum and Instruction from Grand Canyon University, after which she became an Instructional Coach and Professional Development Coordinator. Outside the classroom, Stephanie continues to actively serve her community by volunteering in schools, with military-focused nonprofits, and on military installations. Stephanie's engagement across settings enabled her to build relationships with military-connected families as they navigated the impact of frequent military relocations on their children's academic continuity. In 2024, she was committed to mitigating those impacts and applied to the George W. Bush Stand-To Veteran Leadership Program. As a scholar, Stephanie launched The Continuing Education Plan, now known as Bridge & Banner™, a fiscally sponsored project of the nonprofit Veterans Collaborative™. Bridge and Banner™ provides tools to strengthen partnerships between teachers and parents, amplifying the parents' ability to advocate for their child's academic needs during military transitions. Stephanie is committed to advancing her research on academic continuity as a 2026 Tillman Scholar attending Mississippi State University's Doctor of Educational Policy and Organizational Design program. Stephanie aims to advance educational policy by providing a clear path for action across academic and community programs, ensuring transparency and addressing academic continuity for all vulnerable student populations.Links Mentioned During the EpisodeBridge and Banner WebsiteBridge and Banner on FacebookPsychArmor Resource of the WeekThis week's PsychArmor Resource of the Week is the PsychArmor Course Introduction to Public School Interstate Compact for Military Children. Identifying who qualifies for the Interstate Compact, understanding the five key policy areas the Interstate Compact addresses, and discussing the schools and grades to which the Interstate Compact applies are the learning objectives of this course You can find the resource here: https://learn.psycharmor.org/courses/introduction-to-public-school-interstate-compact-for-military-children Contact Us and Join Us on Social Media Email PsychArmorPsychArmor on XPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families. You can find more about the work that he is doing at www.veteranmentalhealth.com
Dr. Shayne Morris didn't stumble into the microbiome world — he inherited it. Now CEO of both Systemic Formulas and Alimentum Labs, Shayne's grandfather started the company back in 1984 as a healer studying Eastern, Polynesian, and South American medicine, and Shayne spent his career turning that legacy into hard science: how nature actually produces healing, and why the microbes living in and on us — which outweigh every other living thing on the planet combined — do more biochemical work than our own 23,000 genes ever could. In this episode, we get into herbal genomics (Shayne coined the term "herbalomics" back when he realized compounds like turmeric were directly switching genes on and off), why methylated vitamins were considered fringe in 2007 when Systemic started using them, and the surprisingly recent science connecting fungal overgrowth to childhood ADHD and eczema. We also break down the Holobiome Roadmap — Systemic's five-stage system designed to make gut and cellular health personalized without handing a patient fourteen different bottles and no instructions — and why compliance, not complexity, is usually what determines whether a protocol actually works. Along the way: the real story behind why doctors started washing their hands between autopsies and deliveries, and details on Systemic's NextGen event in Ogden, Utah (September 18–20), where Freddie will be speaking on sales as a role of service. Highlights: 00:00 - Introduction to Shane Morris and microbiome's significance 02:20 - Microbes as the foundational layer of health 05:05 - The weight of the microbiome on planetary health 07:01 - How microbes have been misunderstood and underappreciated 09:00 - The impact of diet and environment on microbiome diversity 11:07 - The immune system's development through microbial exposure 13:26 - The importance of personalized microbiome therapies 17:17 - From natural remedies to microbiome science and research 23:19 - Challenges in probiotic product selection and strain specificity 27:43 - Stool testing and genetic tools for microbiome insights 35:14 - Support strategies for aging microbiome health 43:41 - The Holobiome Roadmap: structure and application 50:09 - The influence of lifestyle and sleep on microbiome recovery 65:14 - Supporting neurological health through microbiome balance 70:45 - Upcoming event details and practitioner resources 73:39 - Practical advice for supplementing and maintaining microbiome health Connect with Shayne and Systemic Formulas https://systemicformulas.com/ Instagram: https://www.instagram.com/systemic_formulas/ Discount code: freddie10 Upgrade Your Wellness: LightPathLED: https://lightpathled.pxf.io/c/3438432/2059835/25794 Code: beautifullybroken Silver Biotics Wound Healing Gel: https://bit.ly/3JnxyDD 30% off with Code: BEAUTIFULLYBROKEN MaxGen Labs: https://maxgenlabs.com/BEAUTIFULLYBROKEN CONNECT WITH FREDDIEWork with Me: https://www.beautifullybroken.world/biological-blueprintWebsite and Store: (http://www.beautifullybroken.world) Instagram: (https://www.instagram.com/freddie.kimmelYouTube: https://www.youtube.com/@beautifullybrokenworld Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Dr. Jack Cush Obesity & Gout Dr. Tony Merriman Genome-Wide Association Studies in Gout Dr. Lisa Stamp Gout Management in Patients with Chronic Kidney Disease Dr. Mark Fisher Gout & Mortality
Thanks for listening, and please follow us on Insta @NHPTalent and www.youtube.com/thePOZcast For all episodes, please check out www.thePOZcast.com This special episode is brought to you by our dear friends at Blood Cancer United. An organization very near and dear to me. I'm here to remind you to give to causes that make a difference. You want to help, but you don't know where to start? Blood Cancer United is at the top of my list. They are the global leader in helping patients and families with blood cancer, and your dollars fund research, patient support, and advocacy. Please give today here: Thank you for supporting this important mission. Learn more and donate here: https://pages.lls.org/voy/nyc/nyclls26/aposner Chapters 00:00 The Origins of Jackie Summers 02:53 Education and Rebellion 05:55 Growing Up in Brooklyn 08:59 Embracing Contradiction 11:58 Transitioning to Entrepreneurship 15:01 Creating Sorel Liqueur 22:01 Creative Ways to Enjoy Sorel 23:53 Challenges in the Beverage Industry 25:45 Navigating Racial Dynamics in Business 32:50 Understanding Intersectional Justice 40:17 Embracing Multidimensionality 46:16 Defining True Success Key Topics - Jackie Summers' background and upbringing in Brooklyn - The challenges of breaking into the spirits industry as a Black entrepreneur - The innovation behind shelf-stable sorrel and its cultural significance - Navigating systemic barriers and systemic disenfranchisement - The concept of metabolizing contradiction and embracing complexity - The importance of intersectional justice and social impact in business - Lessons learned from failures and resilience in entrepreneurship - The role of cultural heritage in product development and storytelling - Strategies for navigating industry gatekeepers and systemic biases - The importance of internal and external wealth for success Takeaways - Embrace all parts of your multidimensional self to unlock opportunities. - Metabolizing contradiction requires effort, energy, and transformation. - Systemic barriers can be overcome with persistence, innovation, and purpose. - Cultural heritage is a powerful foundation for creating impactful products. - Success is achieved when internal and external wealth are balanced.
Dr. Robert Terkeltaub 3 New Things it Pays to Know About Gout Pathobiology Dr. Nicola Dalbeth Outcomes of Tophaceous Gout Dr. Ted Mikuls Subclinical Inflammation in Intercritical Gout Dr. Michael Pillinger Gout and Cardiovascular Disease: What's the Risk? What's the Connection?
In today's episode, we spoke with Marlana M. Orloff, MD. Dr Orloff is the Alexander & Johnston Family Endowed Clinical Director in Uveal Melanoma, and associate professor at Thomas Jefferson University Hospital in Philadelphia, Pennsylvania. In our exclusive interview, Dr Orloff discussed the distinct biology of uveal melanoma and why it has historically resisted systemic treatment. Unlike cutaneous melanoma, which carries a high tumor mutational burden and responds robustly to immune checkpoint inhibitors, uveal melanoma sits at the opposite end of the spectrum with low mutational burden, a predominantly liver-metastatic pattern, and an immune-tolerant microenvironment that renders traditional immunotherapy largely ineffective.She provided context on the treatment landscape for patients with HLA-A*02:01–negative metastatic uveal melanoma prior to the phase 2/3 OptimUM-02 trial (NCT05987332), noting that this population had limited options: liver-directed therapies such as percutaneous hepatic perfusion, off-label immune checkpoint inhibitor combinations, or clinical trial enrollment.Dr Orloff then walked through the design and efficacy findings of the trial, which evaluated the combination of darovasertib, an oral PKC inhibitor, plus crizotinib (Xalkori), a MET inhibitor, vs investigator's choice in treatment-naive, HLA-A*02:01–negative patients. The combination demonstrated a median progression-free survival of 6.9 months vs 3.1 months with investigator's choice, with an objective response rate of 37.1% compared with under 5.8% in the control arm. She highlighted the clinical significance of the complete responses observed while noting that overall survival data from the phase 3 portion of the trial remain pending.The discussion also addressed the growing complexity of treatment sequencing as more options emerge, including tebentafusp-tebn (Kimmtrak) for HLA-A*02:01–positive patients, liver-directed and combination approaches, and the investigational TCR-engineered T-cell therapy anzutresgene autoleucel targeting PRAME. Dr Orloff emphasized that in the absence of head-to-head comparisons, sequencing decisions will increasingly be shaped by patient logistics, toxicity profiles, and access to specialized treatment centers.
The Psychedelic Entrepreneur - Medicine for These Times with Beth Weinstein
Benjamin Forest is a retired military officer turned psychedelic author, speaker, and coach. His transformation began with a life-changing psilocybin journey that lifted him from decades of depression and into a radically new way of living. After his own awakening through plant medicine, he began writing, speaking, and coaching around the subject. In 2025, he published his first book: "Trip of a Lifetime -- The Psychedelic Guide to Healing, Loving, and Living." Episode Highlights ▶ Military service and discipline ▶ Psychedelic experiences and healing ▶ Systemic challenges in veteran mental health ▶ The role of psychedelics in redefining masculinity ▶ Preparation and integration of psychedelic journeys Benjamin Forest's Links & Resources ▶ Website: www.benjaminforest.com ▶ Instagram: www.instagram.com/benjamin.forest.bliss ▶Buy his book: https://www.amazon.com/dp/B0FPDPXXXD/ Download Beth's free trainings here: Clarity to Clients: Start & Grow a Transformational Coaching, Healing, Spiritual, or Psychedelic Business: https://bethaweinstein.com/grow-your-spiritual-business Integrating Psychedelics & Sacred Medicines Into Business: https://bethaweinstein.com/psychedelics-in-business ▶ Beth's Coaching & Guidance: https://bethaweinstein.com/coaching ▶ Beth's Offerings & Courses: https://bethaweinstein.com/services ▶ Instagram: @bethaweinstein ▶ FB: / bethw.nyc + bethweinsteinbiz Download Beth's free trainings here: Clarity to Clients: Start & Grow a Transformational Coaching, Healing, Spiritual, or Psychedelic Business: https://bethaweinstein.com/grow-your-spiritual-businessIntegrating Psychedelics & Sacred Medicines Into Business: https://bethaweinstein.com/psychedelics-in-business▶ Beth's Coaching & Guidance: https://bethaweinstein.com/coaching ▶ Beth's Offerings & Courses: https://bethaweinstein.com/services▶ Instagram: @bethaweinstein ▶ FB: / bethw.nyc + bethweinsteinbiz
Show SummaryOn today's episode, we're having a conversation with Dr Debbie Bradbard, Military and Veteran Spouse and the inaugural director of the Boeing Center for Veteran Transition and Military Families at the Virginia Tech in Alexandria, VA. The center's goal is to harness the potential of service members, veterans and their families to thrive in tomorrow's workforce—through skills, mentorship, research, entrepreneurial support, and resources that build future-ready careers and drive economic opportunityEpisode Partner: This episode is sponsored by CareLinx by Sharecare, connecting Veterans, Service Members, and military Families with trusted home care and caregiver support. Provide Support: Take a moment to turn your gratitude into action. For just $15, you can help provide military culture training to one person who supports veterans and their families, equipping them to respond with greater understanding, confidence, and care. GIVE HERE through our giving page at psycharmor.org. Provide FeedbackAs a dedicated member of the audience, we would like to hear from you. If you PsychArmor has helped you learn, grow, and support those who've served and those who care for them, we would appreciate hearing your story. Please follow this link to share how PsychArmor has helped you in your service journey Share PsychArmor StoriesAbout Today's GuestDeborah Bradbard is the inaugural director of the Boeing Center for Veteran Transition and Military Families at the Virginia Tech in Alexandria, VA. As a Senior Researcher at Syracuse University's, D'Aniello Institute for Veterans and Military Families (IVMF), Bradbard spent nearly a decade publishing signature publications and shaping policy and best practices for veterans and military families. Her work on military spouse and veteran employment have been cited by the White House, members of Congress, CNN, the Center for Deployment Psychology and utilized by national professional organizations including The American Psychological Association (APA) and The Society for Human Resource Management Foundation (SHRM) where her work has been downloaded by over 20,000 human resource professionals nationwide. As Director of Research and Policy at Blue Star Families (BSF), she directed implementation of their national survey whose results have had an enduring influence on military family policy on spouse employment, childcare, and financial readiness. In the private sector at Booz Allen Hamilton, she developed clinical support tools that have been utilized by providers across the entire military health system of over 3 million users. A frequent speaker for national conferences, Bradbard educates policy makers, elected officials, and employers about the evolving needs of the military community. A psychologist by training, Dr. Bradbard received her Ph.D. from Auburn University and her MPA from Syracuse University.Links Mentioned During the EpisodeBoeing Center for Veteran Transition and Military FamiliesVirginia Tech in DC on LinkedInDr. Bradbard on LinkedInPsychArmor Resource of the WeekThis week's PsychArmor Resource of the Week is the PsychArmor Course Understanding and Utilizing Your Educational Benefits. provides service members, Veterans and their families with a comprehensive overview of the U.S. Department of Veterans Affairs educational benefits program. You can find the resource here: https://learn.psycharmor.org/courses/Understanding-and-Utilizing-Your-Educational-Benefits Contact Us and Join Us on Social Media Email PsychArmorPsychArmor on XPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families. You can find more about the work that he is doing at www.veteranmentalhealth.com
In this episode, Ryan delves into the common myth that failed Project Based Learning (PBL) implementations are simply the result of ineffective teacher training. He explores the deeper systemic and leadership factors that can make or break successful adoption of PBL in schools. Listeners will gain insight into why training often fails to make lasting change, what distinguishes authentic PBL from surface-level projects, and the critical role of leadership alignment in creating a culture of innovation.Main PointsNot All Training Is Equal: Project Based Learning training that only addresses vocabulary or superficial project scenarios is often insufficient. The most important elements—mindset and authenticity—are frequently missed.Systemic & Leadership Support Matter: Effective PBL requires leadership involvement, clear student outcomes, and systems that support a shift from traditional teaching to a student-centered approach.Teacher Excitement Is Temporary Without Systemic Change: Initial energy from PD can fade quickly if there are no ongoing structures, internal supports, or authentic projects.Leadership Alignment Is Key: Lasting success in PBL must start at the leadership level, with structures for reflective practice, teacher empowerment, and a clear, transparent vision.Authenticity Over Scenarios: Strong PBL involves real-world problem solving and community partnerships, not just scenario-based projects.Notable Quotes"You might get the vocabulary, you might go through the motions, but you might miss the mindset and the authenticity.""If you just did a teacher training without any kind of systems training, leadership training or authenticity, your PBL work is going to be exciting for just a bit and then it's going to fade right back to normal classrooms.""If it doesn't last without you, it was never really a system."Call to ActionReady to assess your school's PBL readiness? Visit pblscore.com to access your PBL Scorecard™ and discover where your training and systems can grow.
Richard McGirr talks to Kasim Aslam as he reveals how he turned a Google Ads mastery into one of the highest-performing real estate campaigns in the U.S. Discover the visionary strategies Richard is pioneering, like tokenizing real estate to democratize access and disrupt the entire industry. You'll learn how owning digital domains like syndications.com can position you as a leader in the next wave of investing, and how to navigate the complex world of SEC regulations without risking everything. Kasim Aslam CEO of Pareto Talent Based in: Scottsdale, Arizona Where to find them: https://kasim.me/ https://www.linkedin.com/in/kasimaslam/ Book your free demo today at bill.com/bestever and get a $100 Amazon gift card. Visit https://malabarhillcapital.com/ for more info. Podcast production done by Outlier Audio Learn more about your ad choices. Visit megaphone.fm/adchoices
Charles Berde, MD, PhD, is the Sara Page Mayo Chair in Pediatric Pain Medicine and a Professor of Anaesthesia at Harvard Medical School. As a co-founder of the Pain Treatment Center at Boston Children's Hospital, he has spent decades at the forefront of pediatric analgesic pharmacology and the development of novel local anesthetics. His extensive translational research focuses on local anesthetic mechanisms and prolonged-duration formulations, making him a preeminent authority on the physiological impacts and safety profiles of these agents in neonates and children. A recipient of the Myron Yaster Lifetime Achievement Award from the Society for Pediatric Anesthesia, Dr. Berde brings unparalleled expertise to the discussion of managing and preventing local anesthetic systemic toxicity (LAST) within the high-stakes environments of the PICU and pediatric operating rooms.Guest Conflicts of Interest (COI)Algavita Bio: Collaborator/Developer of novel, prolonged-duration local anesthetics.Quiver Bioscience: Unpaid Scientific Advisor and co-PI on an NINDS-HEAL grant focused on rare disease pain treatments.Latigo Biotherapeutics: Scientific Advisor and recipient of past research support for novel analgesics development.Algos: Scientific Advisor for non-opioid analgesics development.Learning Objective: By the end of this podcast, listeners should be able to discuss an evidence-based and expert-guided approach to the management of local anesthetic systemic toxicity (LAST) in children.References:Patient and Doctor Reconcile for Greater GoodBerde CB. Toxicity of local anesthetics in infants and children. J Pediatr. 1993 May;122(5 Pt 2):S14-20. doi: 10.1016/s0022-3476(11)80004-1.McMahon K, Paster J, Baker KA. Local anesthetic systemic toxicity in the pediatric patient. Am J Emerg Med. 2022 Apr;54:325.e3-325.e6. doi: 10.1016/j.ajem.2021.10.021. Epub 2021 Oct 25. Lavonas et al. 2023 American Heart Association Focused Update on the Management of Patients With Cardiac Arrest or Life-Threatening Toxicity Due to Poisoning: An Update to the AHA Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2023 Oct 17;148(16):e149-e184. doi: 10.1161/CIR.0000000000001161. Epub 2023 Sep 18. Questions, comments or feedback? Please send us a message at this link (leave email address if you would like us to relpy) Thanks! -Alice & ZacSupport the showHow to support PedsCrit:Please complete our Listener Feedback SurveyPlease rate and review on Spotify and Apple Podcasts!Donations are appreciated @PedsCrit on Venmo , you can also support us by becoming a patron on Patreon. 100% of funds go to supporting the show.Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at pedscritpodcast@gmail.com. You can also check out our website at http://www.pedscrit.com. Thank you for listening to this episode of PedsCrit!
Any time Trump or one of his supporters brings up the 2020 election, insisting he didn't lose it, we hear the usual chorus of groans: why can't he get over it? He lost. Move on. The thing is, I can't get over it either. 2020 was the year everything changed. My entire world was turned upside down because I could see, for the first time, that I was in a bubble, a feedback loop that had shaped my perception of reality. It's just that it wasn't actual reality. It was a curated, hysteria-inducing delusion. It wasn't just me. Go on YouTube, and you'll find hundreds, if not thousands, of people whose lives were fundamentally transformed that year in one way or another. COVID made them quit their job and move into a van. COVID made them decide to divorce. COVID made them learn how to bake sourdough. And a lot of us were red-pilled. It was as though someone pressed the pause button and all of us froze in place for a time. Like in the movie Weapons where the kids suddenly wake up one day…Isolated and shut in, we all turned to social media and the internet, which meant more people were connected than ever before at a time when there were more people alive than ever before. We've never really fully processed what happened to all of us that year.It was the year we stopped trusting the science, the schools, Hollywood, the legacy media, and the government. Children were locked down and staring at their screens, with many of the lost boys finding their way into the dark corners of the internet and would emerge years later fumbling their way toward a rifle and a rooftop.That isn't all of it, or even half of it. None of us would emerge from that year unscathed. We can't talk about it as a country or a people because we are still so divided. The big things divide us, like the vaccine, the masks, the lockdowns, and most especially, the 2020 election.We were stepping into something we did not understand and weren't prepared for. Things have changed enough now that it will be hard to remember just how bad things got after Trump won in 2016. I remember because I was on the inside. I lived it with the Democrats and what would become a Doomsday Cult.We called ourselves “the resistance” even though we had all of the power. Trump and MAGA, they were the real resistance, or at least the revolutionaries going up against the most powerful machine in American history, maybe ever.All I knew was that I had to fight for my side. I woke up every day like a good soldier for the cause and went to battle online, wasting precious time with my daughter, or doing anything else except sitting and staring at a screen and fighting with people I didn't even know over issues that didn't matter with arguments that had no end and went nowhere.Inside the Doomsday Cult, we were awash with mass hysteria because every single day, every time Trump tweeted, the legacy media sent out more waves of hysteria that pulsed through the hive mind and kept reinfecting anyone who scrolled Twitter or Facebook. It was a new emergency every day. We were stuck in an unending state of trauma.The legacy media desperately wants to forget what happened, how they lied and gaslit the public. The consequences for these moral crimes have been minimal. A slap on the wrist for ignoring Joe Biden's cognitive decline, but there has never been a reckoning for what they did to all of us, people who trusted them, in 2020.What Happened to MeMy daughter had to leave her senior year at college to have her graduation on my balcony, but we did it because we were doing our part to help save the country during this once-in-a-generation pandemic.Mobilizing for the cause meant sewing our own masks, displaying them proudly on Instagram. It meant mixing our own hand sanitizer because it was all out at the drug store. Some people were wearing face shields. We were living in fear. We were cowed into silence. Half the country fell into Mass Formation Psychosis. We weren't allowed to attend weddings, churches, or schools, but somehow on Memorial Day, the George Floyd protests became the most important thing in America for months.Systemic racism, they told us, was more urgent than COVID. Really? Bringing the whole country — the whole world — to its knees was less serious than George Floyd dying at the hands of a police officer in Minneapolis? Yes. That's what they were telling us, and everyone was mandated to go along with everything that came next.These were our idols, we were told. It was the new state religion, even if Trump was still the president. This is the ideology we're allowed to gather for. This is worth tear ing down statues, burning buildings, carving out “autonomous zones” and demanding everyone put a black square on Instagram, capitalize the word Black and raise their fists to Black Lives Matter. The madness unfolding on the streets meant Democrats could actually lose in November, I believed. So why wasn't anyone trying to stop them? Why were the Democrats encouraging them? I started wondering what the hell was going on. It felt like unseen hands were manipulating events behind the scenes, and we were all expected to just go along with it.As I began to speak out and ask questions, I was turned into an enemy. “You've changed,” wrote Neera Tanden on Twitter. She was right. I had. By the time Twitter pressured the New York Times to back off their Tom Cotton essay, Send in the Troops, I was done. Maybe I was naive. I didn't understand the assignment. I'd seen too many Frank Capra movies. I'd begun to believe politics was like an Aaron Sorkin screenplay. I thought we were the good guys. We are the side with ethics and decency and fairness.I was like Linda Hamilton in Terminator 2 when Arnold Schwarzenegger shows up, and she thinks he's a bad guy, but when he says, “Come with me if you want to live, she realizes that everything is backward. The people she thought were the good guys weren't. The guy she thought was there to kill her was actually there to save her. By the end of 2020, I was as black-pilled as Jack Nicholson in Chinatown, disillusioned and wide awake. Forget it, Jake. It's Chinatown.But what I saw them do - how we were all manipulated, how they rigged the election to be too big to fail - I could see for the first time that my side had too much power. So much power that American democracy was now beside the point.It didn't matter how the people voted, because we would decide who was allowed to win and who would become an existential threat to the world we were building, the utopia we were building online.When I left the party, I knew I couldn't be fully honest about what I believed happened, though I did say that the election had been rigged. I also couldn't be honest about what I knew about January 6th, at least not in the beginning. When I saw the riot break out, my first thought was, that's not MAGA. They don't do that.And anyway, even if they did, why couldn't the Democrats chalk it up to months of lockdowns and highly enraged, radicalized people on the Right just as there were on the Left that Summer. Why couldn't they? Because it was all still part of the long con, the mass delusion. These ideas were dangerous to hold for anyone in America but especially someone of the Left, and yet, I could not stop it. The truth began knocking. I ignored it as long as I could, but eventually, the knocking became a banging, and I had no choice but to open the door.How to Rig An ElectionOnce you start tugging on the question of why Twitter and Facebook censored the Hunter Biden laptop, you begin to unravel the bigger picture of just how deep the conspiracy went. But you don't need the whole story. You just need to know this: The FBI and the CIA worked against the sitting president to lie to the public that the laptop was “Russian Disinformation.” It was just a standard run-of-the-mill October surprise, timed to help ignite a scandal before the election. But it was also information the public had a right to know, as we would find out later. So anyone who shames Trump for calling the election rigged and denying it was legit will have to answer for this. But if you keep pulling on that string, you'll find the why of it. They were trying to fix all of the problems they believed caused Hillary Clinton's loss. This would be payback for the email scandal that hit her campaign, which she called “Russian Disinformation.” That would also turn out to be untrue.But there were other problems that needed correcting, like lazy voters who assumed Hillary would win because she was so far ahead in the polls and didn't bother turning out. They would fix this problem using COVID as the pretext to change everything about how people vote and how those votes are collected.They knew they had Pennsylvania won long before Election Day and it would only be a matter of convincing the public not to get too excited about a “red mirage.” To all of them, that's the right way to win an election.Trump won Iowa, Ohio and Florida, not to mention the bellwether counties that have decided our elections. The only other time anything like this happened was in 1960, when JFK won in a squeaker. Compare that to 2020, and you can see that something was very off about the numbers. Since the Democrats believed Mark Zuckerberg's Facebook had handed Trump the win in 2016 by using their marketing machine (the Clinton campaign refused their help), it was time for Zuckerberg to undo that damage, which came in the form of a $400 million slush fund used to “fortify” the election but mostly in the heavily blue districts. Had all of this been shared with the whole country as a way to improve our elections overall, that would have been one thing. But it was all done behind the scenes, in the shadows, far from the reach of anyone who might dissent. It was anything but ethical and anything but fair.It was all part of a grand scheme to stay one step ahead of Trump. If they already knew he would claim it was rigged, why not just rig it? Who would the people believe? Trump or the “bipartisan cabal” of unelected bureaucrats hiding in the shadows?The truth is that Trump was pulling ahead because the Left was losing its mind, and Trump picked up on it. He changed his campaign; no matter how many ways they tried to keep him from his rallies, he got the word out anyway. That would explain why he won those key states but lost so much in the popular vote. Our elections should not be decided months before Election Day. Candidates should have to make their case to the people, not hide in the basement and let the system do the work. It's the candidate's job to inspire the voters to vote for the kind of government they want, and it's the voters responsibility to be motivated enough to turn out to the polls and cast their vote. But with an easily manipulated hive mind like the Democrats had cultivated for ten years they didn't need any of it.The Year That Broke AmericaI've never been able to convince anyone of what I believed happened in 2020. If you were on the Left, chances are, you wouldn't be able to see it either. You would have trusted the same people I used to trust: CNN, New York Times, MSNBC, your social media feed.You would have come out of that year thinking Joe Biden won the 2020 election fair and square and that Donald Trump refused to lose, so he led a dangerous assault on the Capitol, putting our democracy under threat. Yet, after everything they did to Trump that year and for the four years prior, what else could he have done except protest? It was just a little too convenient that there happened to be a riot at the same time, a Reichstag Fire that handed absolute power to Team Blue.If you were still trapped inside the Doomsday Cult, you'd have been primed and ready to go to war on your fellow Americans because Vice President Kamala Harris would tell you January 6th was like 9/11 and Pearl Harbor. You would have thought Liz Cheney and the Prime Time Show Trial was legit. What an easy mark you'd be.If you never escaped, as I did, you'd still be trapped inside the Doomsday Cult and never have any idea that none of this is your fault. You were put into a kind of trance in 2020, even before, like the kids in the movie Weapons, frozen in place and used as an army to do the bidding of the Democratic Party.They made you believe, like they made me believe, that every day really was the end of the world as long as Donald Trump was in power. But it was never true, none of it. All the Democrats ever had to do was offer the people something better. If everything Molly Ball wrote about the election the “Secret Bi-Partisan Cabal” supposedly saved, how did Trump win again? In Weapons, the children are put under a spell and aimed at the enemies of the witch. Once the spell is broken, the children wake up and realize the person they should be mad at isn't the one she made them attack, but instead the witch herself for robbing them of their ability to think for themselves. And so it goes with the Democrats.// This is a public episode. 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Interview recorded - 21st of July, 2026On this episode of the WTFinance podcast I had the pleasure of welcoming back Mike Green. Mike Green is Chief Strategist and Portfolio Manager at Simplify Asset Management, and one of the most influential voices on market structure in finance today.During our conversation we spoke about the current situation in markets, the ever increasing leverage through ETF's, what this means for market structure, geopolitical impact and more. I hope you enjoy!0:00 - Introduction1:14 - Overview of the economy and markets?9:02 - Leverage in market12:26 - Hyperscalers fundraising 16:42 - Systemic credit risks?19:04 - Markets driving economy?21:46 - Strong economy24:56 - Geopolitical impact28:23 - China and BRICS29:55 - Plaza accord 2.0?35:00 - US rising vs China?38:52 - FED/treasury backstopping40:26 - Financial nihilism41:42 - One message to takeawayMichael has been a student of markets and market structure, for nearly 30 years. His proprietary research into the shift from actively managed portfolios and investment funds to systematic passive investment strategies has been presented to the Federal Reserve, the BIS, the IMF and numerous other industry groups and associations.Michael joined Simplify in April 2021 after serving as Chief Strategist and Portfolio Manager for Logica Capital Advisers, LLC. Prior to Logica, Michael managed macro strategies at Thiel Macro, LLC, an investment firm that manages the personal capital of Peter Thiel. Prior to Thiel, Michael founded Ice Farm Capital, a discretionary global macro hedge fund seeded by Soros Fund Management. From 2006-2014, Michael founded and managed the New York office of Canyon Capital Advisors, a $23B multi-strategy hedge fund based in Los Angeles, CA, where he established their global macro strategies, managing in excess of $5B of exposure across equity, credit, FX, commodity and derivative markets.In addition to his work as a market theorist and portfolio manager, Michael has been noted for his work as a public speaker and financial media participant. He is a graduate of the Wharton School at the University of Pennsylvania and a CFA holder.Michael Green - Substack - https://www.yesigiveafig.com/Twitter - https://twitter.com/profplum99LinkedIn - https://www.linkedin.com/in/michael-green-9a15142/Simplify - https://www.simplify.us/WTFinance -Instagram - https://www.instagram.com/wtfinancee/Spotify - https://open.spotify.com/show/67rpmjG92PNBW0doLyPvfniTunes - https://podcasts.apple.com/us/podcast/wtfinance/id1554934665?uo=4Twitter - https://twitter.com/AnthonyFatseas
Ilene Fischer is the founder and CEO of Sophia Network, where she guides executive leaders through the turbulence of disruptive change, mergers, reorganizations, and breakthrough innovations – applying her signature Innovation Ecosystems methodology to turn strategic vision into reality. Earlier in her career, she was a partner at Charlie Kiefer's Innovation Associates and managing director at the Tom Peters Company, and has been an advocate for women's causes in an array of fields. “Innovation theatre” in which changes are promised without ever happening is Ilene's bete noire. Give me a corporate culture steeped in fear, and you can be sure that vital experimentation won't be valued. In this interview, she makes a strong case for constant iteration that cuts across departmental silos in order to keep pace with the nine disruptive factors she sees as happening simultaneously in the business world today. Is AI big? Yes. But so is what quantum computing makes possible. One of the biggest points she makes in this conversation is that companies are starved for multidisciplinary talent, and the talent they do manage is attract will leave promptly if not given a license to apply that talent and achieve results. Change starts with deep listening (no judging) and grows exponentially into a virtuous circle if done with respect; fail that test, and a vicious cycle will emerge instead. Ilene's book Innovation Ecosystems: A Dynamic Blueprint for Organizational Success and Engagement is published by John Murray Press, a division of Hachette. The book will be released on October 20 and is available for preorder now. Real Transformations: Business Change That Works from the Inside Out is co-hosted by Julie Anixter and Dan Hill, PhD, entrepreneurs with deep experience as corporate change agents, devoted to helping companies make continuous change work for everyone through clarity and connection. To learn about their keynote talks, workshops and labs, check out Real-Transformation.com. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network
In today's episode, I sat down with Lara Morgan Lee, MD, a board-certified sports medicine physician and former team doctor for elite professional and collegiate athletes, to talk about what happens when we apply a sports medicine approach to motherhood. We dive into the gaps that still exist in postpartum healthcare and why returning to function requires more than a six-week clearance. Dr. Morgan shares why the same principles we use to rehabilitate and support athletes—structured progressions, coaching, and multidisciplinary care—need to be part of the conversation for moms, too. This conversation is a reminder that supporting mothers can't fall on one coach, clinician, or provider. It takes collaboration and a willingness to rethink the way we approach maternal health and athletic performance. Connect with Dr. Morgan · Instagram: @sportsdrmorgan · Website: https://sportsdrmorgan.com/ Need workouts for your pregnancy or postpartum? Check out my programs (now with app access!): The Pregnant Athlete Training Program: https://go.pregnancyandpostpartumathleticism.com/the-pregnant-athlete-program The 8-Week Postpartum Athlete Training Program: https://go.ppaprograms.com/pp-program Training Jiu-Jitsu during pregnancy or postpartum? I've created a FREE guide to help you train with confidence, understand key considerations, and navigate this season as a combat athlete.
“Motor City” feels like somebody found a filthy '70s revenge movie in the trunk of a burned-out Cadillac, wiped off the blood, and restored the whole thing in 4K and Dolby Atmos. It is loud, violent, strangely romantic and, thankfully, almost entirely uninterested in people sitting around explaining themselves. The fists, engines, needle drops and occasional shotgun blast handle most of the talking.Directed by Potsy Ponciroli ("Greedy People," "Old Henry") and written by Chad St. John, the film stars Alan Ritchson (“Reacher") as John Miller, a working-class Detroit mechanic framed by a wealthy gangster after falling in love with the man's girlfriend, Sophia, played by Shailene Woodley. After spending years behind bars, Miller emerges with revenge on his mind and very little concern for whether he survives long enough to enjoy it.Ben Foster, Pablo Schreiber, Lionel Boyce, Ben McKenzie and Amar Chadha-Patel also star in the nearly dialogue-free action thriller, which arrives in theaters on July 24 through IFC Films.
What if your relationship struggles aren’t just personal—but shaped by the systems you live in? Akilah Riley Richardson returns to explore how systemic trauma quietly shapes our relationships, nervous systems, and sense of self. Drawing from her work with marginalized couples, she introduces the concept of relational privilege and explains why healing cannot be separated from the social systems we live in. Together, Akilah and Sue challenge traditional Western therapy models, discuss the importance of “responsible externalizing,” and explore how therapists can create space for grief, imagination, and genuine connection instead of trying to fix what cannot simply be solved. “The experiences of marginalized people are often devalued even by helping professionals, and this text is my dedication to carving a space where we, as practitioners, can ensure that we are of service in a way that is rooted in the realities of our people. It is also a reflection of my obligation to marginalized couples and individuals. My sincere wish for them all is that they are never harmed in therapy but instead uplifted. ” – Akilah Riley-Richardson Time Stamps for The Hidden Weight of Systemic Trauma: How Oppression Shapes Our Relationships with Akilah Riley-Richardson (306) 02:05 The systemic trauma faced by marginalized couples 04:12 Barriers for global south therapists and voices 08:00 Fear, threat, and navigating space as a marginalized person 09:57 Relational privilege and systemic influence 12:03 The role of colonial Christianity in systemic trauma 17:50 The danger of model dogmatism in therapy 20:06 Neurobiological threat and systemic trauma 22:02 Practicing responsible externalizing in therapy 26:07 The grief of systemic trauma and loss 28:04 The limitations of evidence-based models 29:58 The need for imagination and community in healing 31:47 The concept of lostness and liminality in trauma 34:06 The danger of attachment to models and frameworks 35:59 Differentiating systemic from relational reality 38:10 Yoruba and indigenous healing traditions 41:59 The influence of colonialism and imperialism on therapy 43:53 Acknowledge systemic trauma in therapist self-awareness 49:57 Habits of survival and internalized oppression 51:52 The impact of systemic trauma on body and mind About our Guest – Akilah Riley-Richardson, MSW, CCTP Akilah Riley-Richardson, MSW, CCTP is a dedicated therapist, educator, and researcher with several years of experience. As a Certified Clinical Trauma Professional and STAIR Method Certified clinician, Akilah specializes in relational healing, focusing on the needs of couples and individuals, both in the Caribbean and internationally.Her expertise extends to supporting sexual and racial minorities, ensuring that her practice is inclusive and culturally sensitive. Akilah's commitment to education and advocacy has led her to consult for esteemed organizations, including NASTAD, I-TECH, CARPHA, and CVC, where she has made significant contributions to healthcare training and community support. She has presented her work at various prestigious forums, such as the Psychotherapy Networker Symposium, Academy of Therapy Wisdom, Harvard Medical School, Chicago School of Psychology and the Black Mental Health Symposium. From 2012 to 2025, she served as a Social Work Educator at the University of the Southern Caribbean, mentoring future leaders in the field. Currently, she serves as a Research Supervisor and Examiner at the University of the West Indies Global Campus. As the founder of the Relational Healing Institute and the creator of the P.R.I.D.E. model, Akilah is passionate about advancing relational therapies. Her book, “Marginalized Couples in Therapy” reflects this passion. Resources for The Hidden Weight of Systemic Trauma: How Oppression Shapes Our Relationships with Akilah Riley-Richardson (306) Marginalized Couples in Therapy: Interventions for Healing from Systemic Trauma – Akilah’s new book, use this link for 20% off. Get your copy today! Akilah’s website – Resources, opportunities and additional information Beyond Attachment Styles course is available NOW! Learn how your nervous system, your mind, and your relationships work together in a fascinating dance, shaping who you are and how you connect with others. Online, Self-Paced, Asynchronous Learning with Quarterly Live Q&A’s! Earn 6 Continuing Education Credits – Available at Checkout As a listener of this podcast, use code BAS15 for a limited-time discount. You are invited! Join our exclusive community to get early access and discounts to things we produce, plus an ad-free, private feed. In addition, receive exclusive episodes recorded just for you. Sign up for our premium Neuronerd plan!! Click here!! Get your copy of Secure Relating here!!
Show SummaryOn today's episode, we're having a conversation with Veteran family member Chris Weedon, Founder and Executive Director of the Mentally Shredded Foundation, a nonprofit dedicated to preventing burnout and strengthening mental resilience through movement, reflection, conversation, and community.Episode Partner: This episode is sponsored by CareLinx by Sharecare, connecting Veterans, Service Members, and military Families with trusted home care and caregiver support. Provide Support: Take a moment to turn your gratitude into action. For just $15, you can help provide military culture training to one person who supports veterans and their families, equipping them to respond with greater understanding, confidence, and care. GIVE HERE through our giving page at psycharmor.org. Provide FeedbackAs a dedicated member of the audience, we would like to hear from you. If you PsychArmor has helped you learn, grow, and support those who've served and those who care for them, we would appreciate hearing your story. Please follow this link to share how PsychArmor has helped you in your service journey Share PsychArmor StoriesAbout Today's GuestChristopher D. Weedon, MBA, is the Founder and Executive Director of the Mentally Shredded Foundation, a nonprofit dedicated to preventing burnout and strengthening mental resilience through movement, reflection, conversation, and community. A former collegiate soccer captain who also competed at the semi-professional level, and a former strength and conditioning coach, Christopher created the Mentally Shredded 3-in-1 Method after navigating his own mental health challenges and recognizing the need for proactive, accessible wellness experiences. Since 2022, the organization has served more than 2,000 participants through live programs and reached more than 10,000 people through educational content and The Mentally Shredded Show podcast. Christopher is building a scalable model that equips organizations and communities to make mental wellness a regular practice rather than a crisis response.Links Mentioned During the EpisodeMentally Shredded WebsiteChris Weedon on InstagramMentally Shredded on InstagramChris Weedon on LinkedInPsychArmor Resource of the WeekThis week's PsychArmor Resource of the Week is the PsychArmor Course Bolstering Resilience, part of the Brain Health and Wellness Learning Series. This mini-course series on resilience, sponsored by Wounded Warrior Project, spotlights five supporting factors proven to bolster resilience among service members, veterans, their families, and caregivers: SMART goals, mental health, nutrition, sleep, and exercise. Each element builds upon a foundation of service and increases the ability to successfully cope with high levels of stress and pressure. You'll learn why these supporting pillars are so important to overall well-being, their application in daily life, and how it's never too late to make a lasting change. You can find the resource here: https://learn.psycharmor.org/courses/WWP-BHW-bolstering-resilience Contact Us and Join Us on Social Media Email PsychArmorPsychArmor on XPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families. You can find more about the work that he is doing at www.veteranmentalhealth.com
Roughly half of the average American's daily calories now come from ultra-processed foods — and cutting them out changes how you feel faster than you'd expect. Nurse Doza breaks down five shifts that show up within weeks: steadier blood sugar and energy, a healing gut, lower inflammation, clearer thinking, and hunger hormones that finally reset. Learn what really separates processed from ultra-processed food, and why just two weeks of whole food can change everything. Featured Product: Boost by MSW Nutrition When you're riding the ultra-processed blood-sugar roller coaster, energy is the first casualty — the mid-afternoon crash, the brain fog, the reach for the next quick fix. Boost is the multivitamin you can actually feel: 2,500 mcg of methylated B12, a full multivitamin plus B-complex, electrolytes, and plant-based antioxidants including S-acetyl-L-glutathione. Clean, slow-release energy from one stick in water — no added sugar, no crash — so real food finally has a fair shot at steadying you out.
In this episode, we review the high-yield topic of Systemic Review and Meta-Analysis from the Stats section at Medbullets.comFollow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbulletsLinkedin: https://www.linkedin.com/company/medbullets
Welcome to the latest Midlife Minute episode. Today, we're talking about elimination diets, iron, and ferritin. I share my personal experience with prolonged antibiotic and antifungal use, clarify what the research actually says about restrictive diets, nutrient deficiencies, fatigue, and brain fog, and highlight why it's essential to understand your iron status during the menopausal transition. IN THIS EPISODE, YOU WILL LEARN: Why elimination diets can be helpful in specific situations, but may not be appropriate for the long term How removing major food groups without a replacement strategy can cause unintended nutrient deficiencies Why some women become more reactive to certain foods during the menopausal transition How women's protein requirements increase during perimenopause and menopause How low ferritin is often overlooked in women, even when they are experiencing fatigue and brain fog Why women's iron status fluctuates during the perimenopause to menopause transition How some women experience significant symptoms long before anemia appears in their standard lab work Connect with Cynthia Thurlow Follow on X, Instagram & LinkedIn Check out Cynthia's website. Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow. Purchase Cynthia's book, The Menopause Gut. Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Links: 1. The Importance of Nutrition in Menopause and Perimenopause—A Review 2. Weight gain during the menopause transition: Evidence for a mechanism dependent on protein leverage 3. The gut microbiota in menopause: Is there a role for prebiotic and probiotic solutions? 4. Cognitive Performance in Relation to Systemic and Brain Iron at Perimenopause 5. Accelerated Increase in Ferritin Levels During Menopausal Transition as a Marker of Metabolic Health 6. Iron and Menopause: Does Increased Iron Affect the Health of Postmenopausal Women? 7. Iron deficiency in peri-menopausal women: Clinical considerations from an expert consensus 8. Cognitive Function in Peri- and Postmenopausal Women: Implications for Considering Iron Supplementation
Show SummaryOn today's episode, we're having a conversation with Marine Corps Veteran Chris Gonzalez, Co-Founder of A-G Associates, an organization that provides insight, expert guidance, and lived experience to strengthen public health and safety systems, advance military and veteran wellbeing, and help mission-driven organizations achieve measurable impact. We talk about their partnership with PsychArmor to support MCON Health, and their recently announced Fall In initiative. Episode Partner: This episode is sponsored by CareLinx by Sharecare, connecting Veterans, Service Members, and military Families with trusted home care and caregiver support. Provide Support: Take a moment to turn your gratitude into action. For just $15, you can help provide military culture training to one person who supports veterans and their families, equipping them to respond with greater understanding, confidence, and care. GIVE HERE through our giving page at psycharmor.org. Provide FeedbackAs a dedicated member of the audience, we would like to hear from you. If you PsychArmor has helped you learn, grow, and support those who've served and those who care for them, we would appreciate hearing your story. Please follow this link to share how PsychArmor has helped you in your service journey Share PsychArmor StoriesAbout Today's GuestChris Gonzalez is President and Co-Founder of A-G Associates (A-G). Chris' accolades range from entrepreneurial awards on the Inc, 5000 (Inc. Magazine) Vet100 (Institute for Veteran and Military Families) and Young Alumni Achievement Award (Frostburg State university) to Bridging the Gap Achievement Award by the Greater Baltimore Committee for philanthropic efforts. Under Chris' leadership, A-G has grown into one of the fastest growing companies in the country, placing in the top 15% of the Inc. 5000 list (#592). A-G has made a significant contribution to the fields of mental health and substance use for military personnel, military families, veterans, behavioral health clinicians, peer support specialists and others. These events have led to the development of policy, resources and grant programs. A U.S. Marine and combat veteran with tours in Iraq and Afghanistan, Chris drives organizational and program transformation initiatives across the public, private, and non-profit sectors. Chris is the Associate Producer of Bastards' Road, a full-length film about a Marine Corps Veteran who conquers post-traumatic stress by walking across the country. He has also coached several fitness programs and served on the Board of Directors for the Maryland Hispanic Chamber of Commerce, Health Care Access Maryland, Mentoring Mentors and American Warrior Festival/Strength in Numbers. Chris has been a keynote speaker at the Center for Naval Analyses, Mental Health America, Frostburg State University's Sloop Leadership Institute, and the Project Management Institute. He is a certified Facilitator/ Trainer through the Marine Corps, WholeScale Change™ facilitator and Project Management Professional (PMP). He is a graduate from Operation Hand Salute, an Executive Development program through John F. Kennedy University and AT&T. He received his BS in Social Science from Frostburg State University in 2001, and his Master of Arts in Education from Towson University.Links Mentioned During the EpisodeLinks Mentioned During the EpisodeA-G AssociatesMCON HealthThe Fall In InitiativePsychArmor Resource of the WeekThis week's PsychArmor Resource of the Week is the Behind the Mission podcast episode 223 of the Behind the Mission Podcast highlighting MCON. In this episode, we have a conversation with Marine Corps veteran Waco Hoover, an entrepreneur and investor with over 20 years of experience in venture capital, M&A, entertainment, media and live events. We talk about MCON, an annual event that celebrates military culture and includes MCON Health conducted in partnership with PsychArmor. You can find the resource here: https://psycharmor.org/podcast/waco-hoover-mconContact Us and Join Us on Social Media Email PsychArmorPsychArmor on XPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families. You can find more about the work that he is doing at www.veteranmentalhealth.com
This week on Dentistry Unmasked, Pam and Brian sit down with Dr. Mia Geisinger, past president of the American Academy of Periodontology, for a powerful conversation about the undeniable connection between oral inflammation and systemic health. For too long, “a little bleeding” has been minimized or accepted as normal—but Dr. Geisinger makes it clear: bleeding is a sign of inflammation, and inflammation matters. With dozens of systemic illnesses linked to or exacerbated by periodontal inflammation, dental professionals have a critical opportunity to help patients understand that periodontal health is not just about saving teeth—it is about supporting whole-body health. In this episode, Dr. Geisinger breaks down the science, the responsibility, and the opportunity we have as clinicians to collaborate with our patients, improve periodontal outcomes, and reduce the oral inflammatory burden that may contribute to systemic disease. If you have ever struggled to get patients to take bleeding gums seriously, this conversation will give you the language, confidence, and clinical perspective to change the way they see their oral health.Tune in for a compelling episode that reminds us why periodontal health is no longer optional—it is foundational.
JOIN PATREON FOR EARLY UNCENSORED EPISODE RELEASES: https://www.patreon.com/JulianDorey CLIPPERS DISCORD: https://discord.gg/8QmWEKJ3BT (***TIMESTAMPS in Description Below) ~ Fat Electrician and Veteran w/ a Sign are both veterans and YouTube creators. They have their own channels and multiple podcasts including "Unsubscribe Podcast" & "Underwhelming Podcast." FAT ELECTRICIAN's LINKS: - YT: https://www.youtube.com/@the_fat_electrician - POD: https://www.youtube.com/@unsubscribepodcast - IG: https://www.instagram.com/the_fat_electrician/?hl=en VETERAN w/ A SIGN's LINKS: - IG: https://www.instagram.com/veteranwithasign/?hl=en - POD: https://www.youtube.com/@UnderwhelmingPodcast FOLLOW JULIAN DOREY INSTAGRAM (Podcast): https://www.instagram.com/juliandoreypodcast/ INSTAGRAM (Personal): https://www.instagram.com/julianddorey/ X: https://twitter.com/julianddorey JULIAN YT CHANNELS - SUBSCRIBE to Julian Dorey Clips YT: https://www.youtube.com/@juliandoreyclips - SUBSCRIBE to Julian Dorey Daily YT: https://www.youtube.com/@JulianDoreyDaily - SUBSCRIBE to Best of JDP: https://www.youtube.com/@bestofJDP ****TIMESTAMPS**** 0:00 - Live podcasting and military transition 11:23 - Aldi, Poisoned American food & politics 26:19 - Agriculture, Iowa cancer & NJ Pumping Gas Argument 42:02 - AI, Thiel & skilled trades 53:18 - Trades, YouTube & corporate inefficiency 1:02:50 - Social security & opioid crisis 1:13:10 - Boomers, democracy flaws, voting barriers 1:22:56 - Voting tests and civil service 1:33:00 - Poverty, 9/11 & joining military 1:42:02 - Afghanistan deployment & Marja invasion 1:54:00 - Combat losses & supportive wives 2:07:55 - Marrying your high school sweetheart 2:08:57 - Logan Weston: The Fighting Preacher 2:23:08 - Merrill Marauders & bayonet charges 2:24:40 - Military history & political wars 2:43:35 - Afghanistan withdrawal & veteran healing 2:58:20 - Meeting online & veteran PTSD 3:08:18 - Systemic abuse & Afghan reality 3:26:49 - Fat Electrician & VWAS's Work CREDITS: - Host, Editor & Producer: Julian Dorey - COO, Producer & Editor: Alessi Allaman - https://www.youtube.com/@UCyLKzv5fKxGmVQg3cMJJzyQ - In-Studio Producer: Joey Deef Julian Dorey Podcast Episode 446 - Fat Electrician & Veteran w/ a Sign Music by Artlist.io Learn more about your ad choices. Visit podcastchoices.com/adchoices
CardioNerds co-chairs Dr. Dinu Balanescu and Dr. Billy Joe Mullinax, along with FIT lead Dr. Shiavax Rao, discuss the evolving landscape of randomized controlled trials in pulmonary embolism with Dr. Jay Giri, interventional cardiologist, Associate Professor of Medicine, and Director of the Cardiovascular Catheterization Laboratories at the Hospital of the University of Pennsylvania. This episode examines the historical evidence behind systemic thrombolysis, the emergence of catheter-directed therapies and mechanical thrombectomy, and the landmark RCTs – STORM-PE, PEERLESS, HI-PEITHO, and PEERLESS II – that are reshaping intermediate-risk PE management. The discussion highlights challenges in PE trial design, the critical importance of clinical deterioration as an endpoint, and why this era represents an unprecedented wave of evidence generation in PE. Audio editing for this episode was performed by CardioNerds Intern, Dr. Julia Marques Fernandes. Dr. Dinu Balanescu and Dr. Billy-Joe Mullinax are Co-chairs for the CardioNerds PE Series, developed in collaboration with the PERT Consortium. Enjoy this Circulation 2022 Paths to Discovery article to learn about the CardioNerds story, mission, and values. CardioNerds Pulmonary Embolism PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls: Systemic thrombolysis in intermediate-risk PE reduces hemodynamic decompensation but at the cost of ~1.5–2% intracranial hemorrhage risk – a near-zero net benefit that has driven the search for safer catheter-based alternatives. “Focus on clinical deterioration, not mortality” – Due to crossover design in contemporary PE RCTs, control-arm patients who decompensate are rescued with advanced therapies, biasing mortality toward the null. Clinical deterioration is the most informative endpoint to watch in HI-PEITHO, PRAGUE-26, and PEERLESS II. HI-PEITHO is the first large RCT to demonstrate that catheter-directed fibrinolysis plus anticoagulation significantly reduces the composite of PE-related death, cardiorespiratory decompensation, or PE recurrence versus anticoagulation alone (RR 0.39; 95% CI 0.20–0.77; P=0.005), with no intracranial hemorrhage in either arm. The four major upcoming/recently reported PE RCTs (HI-PEITHO, PRAGUE-26, PEERLESS II, PE-TRACT) enroll progressively different risk populations – from the most enriched (HI-PEITHO) to the most permissive (PE-TRACT, which includes intermediate-low risk patients) – enabling a nuanced understanding of which patients benefit most from intervention. PE device clearance follows a fundamentally different FDA pathway than structural heart devices (single-arm safety/efficacy studies vs. mandated RCTs), yet market forces and clinical need have ultimately driven industry and government to sponsor large-scale RCTs – a lesson in how evidence development can evolve organically alongside regulatory frameworks. Notes: Notes drafted by Dr. Shiavax Rao. Question #1: What is the current evidence behind advanced PE therapies? Systemic thrombolysis: Sixteen RCTs over 40 years (1972–2014) enrolling nearly 2,000 patients have studied systemic thrombolysis in intermediate-risk PE. The landmark PEITHO trial (n=1,006) showed that tenecteplase reduced the composite of death or hemodynamic collapse (2.6% vs. 5.6%; P=0.015), driven primarily by reduced hemodynamic decompensation (1.6% vs. 5.0%; P=0.002). However, this came at the cost of increased major bleeding (6.3% vs. 1.5%; P
Host Alycia Anderson welcomes Jessica Lopez, a disability rights advocate, keynote speaker, marketing strategist, and digital accessibility consultant working at the intersection of inclusive marketing, brand strategy, disability inclusion, accessible technology, and corporate accessibility. A recent Arizona State University graduate and Obama-Chesky Voyager Scholar, Jessica brings lived experience, business insight, and bold advocacy to conversations about accessible education, disability pride, inclusive hiring, digital accessibility, SEO, workplace inclusion, and why building accessibility from the start creates stronger brands, better customer experiences, and measurable business impact. Jessica shares her lived experience as a woman born without hands and feet, a hearing aid user, and someone who later developed a chronic illness that changed the course of her education. From growing up in performing arts school, riding horses through adaptive recreation, and learning confidence on stage, to navigating inaccessible education systems and eventually graduating after gaining access to online learning, Jessica's story is a powerful reminder that disabled people are not limited by their bodies, but by systems that fail to adapt. In this episode, Alycia and Jessica explore disability pride, accessible education, corporate inclusion, digital accessibility, inclusive marketing, career confidence, the ROI of accessibility, and what happens when companies stop assuming and start asking disabled people what they need. Confidence, Access, Advocacy, and “Why Not Me?”: The Big Takeaways from Jessica Lopez ♿ Disability identity, pride, and being born without hands and feet
Preview: Professor Fitzhugh Brundage examines the descent of Civil War prisons into systemic brutality. Focusing on Richmond's Libby Prison, a repurposed tobacco warehouse, he explains how the initial intent of civilized exchanges failed. Brundage details how the experiences of literate Union officers helped spread early accounts regarding these notorious Confederate facilities.1865 RICHMOND VA
Iran's Economic Demands in Switzerland. Guest: Jonathan Sayeh and Bill Roggio. Jonathan Sayeh argues that Iran is seeking a systemic economic lifeline through billions in unfrozen assets. He criticizes recent US oil waivers as a sign of caving to pressure. Iran aims to link a Lebanon ceasefire to negotiations to delay nuclear discussions and drive a wedge. 91705
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