Podcasts about Lumen

Send a textBiology of obesity resistance and factors influencing weight gain in humans and animals.TOPICS DISCUSSED:Historical views on obesity: In some cultures, like northern Africa or Stone Age societies, high body fat signaled status or attractiveness due to food scarcity, unlike today's focus on leanness amid calorie abundance.Energy balance components: Metabolizable energy (95% absorption on average, but varying 1-11%) and unabsorbed nutrients excreted as waste significantly influence weight.Obesity resistance in animals: Inbred mouse strains show wide variation in weight gain on high-fat diets, often somewhat uncoupled from overeating, suggesting roles for feed efficiency, energy expenditure, or waste rather than intake alone.Genetic & twin studies: Monozygotic twins overfed 1,000 extra calories daily vary widely in weight gain (4-13 kg), indicating genetic influences, while mouse litter size affects lifelong obesity propensity via early-life programming.Bloodborne factors & hormones: Parabiosis studies led to leptin's discovery for defending against weight loss, but evolutionary logic suggests systems also prevent excess gain, though modern environments may weaken this.Human thinness research: Constitutionally thin people snack more, move less, yet have better cardiometabolic health, but we don't yet understand why.GLP-1 drugs & future directions: These slow gut transit and suppress appetite, but obesity's root causes remain unclear; emerging thinness studies could inform prevention beyond drugs.ABOUT THE GUEST: Jens Lund, PhD is a postdoctoral researcher at the University of Copenhagen's Novo Nordisk Foundation Center for Basic Metabolic Research.RELATED EPISODE:M&M 132 | Obesity Epidemic, Diet, Metabolism, Saturated Fat vs. PUFAs, Energy Expenditure, Weight Gain & Feeding Behavior | John SpeakmanSupport the showHealth Products by M&M Partners: SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off. Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

While many companies focus only on buying new AI tools, the real secret to success often lies in changing how leaders think and act to drive a massive business turnaround. In this episode, Anna White, EVP and Chief People Officer at Lumen, joins the show to discuss how a major networking company is transforming its business through a deep focus on leadership and AI. We explore how leaders must shift from being "knowers" to "learners" by embracing curiosity and a growth mindset. The discussion covers practical steps like launching an AI literacy academy for all employees, using "Dare to Lead" training to build courage, and managing the risks of "work slop" by ensuring human judgment always checks AI work. We also dive into real examples of AI pilots, such as the GoalPro tool for aligning targets, and examine how to prepare for a future hybrid workforce where humans manage AI agents. This conversation offers a clear roadmap for HR leaders handling the complex mix of culture change and digital transformation. ---------- Start your day with the world's top leaders by joining thousands of others at Great Leadership on Substack. Just enter your email: ⁠⁠https://greatleadership.substack.com/ Future-ready organizations are built, not hoped for. My latest book, -The 8 Laws of Employee Experience shows how. Order here: 8exlaws.com

Digital assets are have for several years been the main growth drivers for most media owners. This is as true of TV – ITV just announced it saw 10% growth in digital revenues compared to flat overall revenue growth – as it is in publishing, as seen in the latest consumer ABC figures, as it is OOH, as it is in, of course, social media and search.So it was little surprise that, according to IAB UK's latest digital adspend report, in 2025 the UK's digital ad market grew 10% to £40.5bn pounds. It's a staggering number, especially when you consider that AA/Warc estimated the total UK ad market reached £46.9bn pounds last year.Adspend on social media grew 21% year on year to £11.5bn, even as industry leaders at both agencies and competing media owners made the case to "turn down the toxic" by divesting from social and reinvesting in more trusted media channels.Elizabeth Lane is the head of insight at IAB UK. She sat down with host Jack Benjamin her to unpack the latest adspend report, and why video in particular was a driving force for digital growth last year.The duo also discussed how AI is changing search to the detriment of publishers, what to watch out for in retail media, and why gaming and digital OOH also saw double-digit growth in 2025.Highlights:1:21: Toplines from IAB UK's 2025 Digital Adspend Report3:41: Social's pivot to video helps explain its 20% growth rate13:39: Search, retail media and gaming: disruption and missed opportunities24:06: How AI could change digital investmentRelated articles:UK adspend expected to surpass £50bn for first time in 2026High-attention media is more profitable, finds Peter Field, Lumen and NewsworksReddit looks to scale through search, performance and insightWhy audio is embracing video — with News Broadcasting's Dave Wilcox and Russell Pedrick---Visit The Media Leader for the most authoritative news analysis and comment on what's happening in commercial media. LinkedIn: The Media LeaderYouTube: The Media Leader

Editorial  La Comisión Episcopal para la Doctrina de la Fe de la Conferencia Episcopal Española ha publicado una nota doctrinal sobre el papel de las emociones a la hora de practicar la fe, titulada Cor ad cor loquitur —“El corazón habla al corazón”—. El documento fue autorizado para su publicación por la Comisión Permanente en la reunión de los días 24 y 25 de febrero en Madrid. Noticias internacionales  Argentina: Recuperan reliquias de la Santa Cruz perdidas en 1944  República Checa: Un «crowdfunding» de fieles ya paga los salarios sacerdotales  Irán: Realidad de los cristianos iraníes  Ecuador: Horas santas, vía crucis… para hacer de marzo el mes de la vida Noticias nacionales  Un joven con cáncer es ordenado sacerdote  «Busca la santidad», nueva campaña nacional para el 8M  Cerro de los Ángeles, Tabor para trece nuevos consagrados Noticias de la Santa Sede  Histórica visita de León XIV a Mónaco  El Papa pide orar en marzo por la paz  Audiencia General sobre la Constitución dogmática Lumen gentium

Dan Brouillette has always worked in creative fields—he was a professional photographer before launching Lumen in the waning days of the pandemic—but he's always been particularly attracted to the technical aspects of creation. Like every IPA-focused brewer, he's on a neverending search for the most expressive, layered, and interesting hops. But he's also found that the information upon which many brewers rely when choosing hop lots often tells an incomplete story. Total oil numbers can be misleading, as they include oils that don't survive the brewing process; hops that smell good relative to others at selection may not have high enough oil concentration to punch through in finished beer. Brouillette has found that using past chemical data paired with his own sensory can be far more effective when seeking out hops that are going to give him the impact he seeks. In this episode, Brouilette shares: how spreadsheets are often a better tool for selecting hop lots than the old-fashioned rub his process for earmarking specific hop compounds at certain thresholds to ensure they're effective in beer designing different types of hazy IPA that appeal to different use cases and drinkers achieving beautiful hop expression in hazy IPAs with less than 4 percent ABV brewing hazy IPA with only 40 percent base malt And more. “We're brewing our World Beer Cup beers right now, and those will be much different than a beer that I want to make Top Drops on Instagram,” Brouilette says. “They're just different audiences. We don't brew one type of hazy IPA. There are different segments and sub-styles within the style, and we brew all of those.” G&D Chillers G&D's new Elite 290 Micro-series runs on a Natural Refrigerant with near-zero Global Warming Potential—built for brewers who care about sustainability and performance. They recently built one for New Belgium Brewing, delivering around 50% energy savings over CO₂ systems and 9% more efficiency than A2Ls. That's real-world impact from a brewery that knows what it takes. With 24/7 support and remote monitoring, your cold side stays dialed in—day or night. Learn more about sustainable chiller solutions at gdchillers.com/podcast. Berkeley Yeast Berkeley Yeast just launched Dry Tropics London! Our best-selling liquid yeast strain, now with all the ease-of-use benefits of dry yeast. Dry Tropics London delivers the soft, pillowy mouthfeel and juicy character you'd expect from a top-tier London Ale strain, but with a serious upgrade: a burst of thiols that unleash vibrant, layered notes of grapefruit and passion fruit. A lot of brewers love the clean passion fruit you get from Tropics, but they don't want every IPA to be a tropical-fruit bomb. At the dry yeast price point, you can pitch and ditch without breaking the bank. Or, you can co-pitch with your house strain to adjust the intensity of the notes. And with nationwide free shipping, there's never been a better time to try Dry Tropics. Order now at berkeleyyeast.com and experience the ease and impact of Dry Tropics London Yeast. PakTech This episode is sponsored by PakTech—delivering craft-beer multipacking you can trust. Our handles are made from 100 percent recycled plastic and are fully recyclable, helping breweries close the loop and advance the circular economy. With a minimalist design, durable functionality you can rely on, and custom color matching, our carriers help brands stand out while staying sustainable. Trusted by craft brewers nationwide, we offer a smarter, sustainable way to carry your beer. To learn more, visit paktech-opi.com. Indie Hops Strata Cryo The multilayered wonders of Indie Hops Strata are now easier than ever for brewers to tap into. Introducing Strata Cryo, in collaboration with Yakima Chief Hops. Whether brewing up a single-hop Strata IPA to wow customers with the depth of flavor this variety delivers or modernizing your flagship IPA to continue setting the highest standards, Strata T99, Strata CGX, Strata HyperBoost, and now Strata Cryo provide the tools for you to create your unique masterpiece. Indie Hops Strata. Life is short. Let's make it flavorful! Midea 50/50 Flex If you're like many podcast listeners, you've got a lot of beers at home, and your regular fridge is at capacity. Enter the Midea 50/50 Flex—the industry's first dual compartment three-way convertible freezer. Here's what all that means for you: options! The 50/50 has the power to be all freezer, all fridge, or a little bit of both. But you'll probably want to use those 20 cubic feet as a massive, garage-ready beer fridge. You can also change which side the door is on or how you want the shelves to be arranged—the 50/50 totally flexes to fit your life. Plus, it's designed to maintain a stable temperature even in non-climate-controlled conditions—so you can crack a cold one even on the warmest days in the man cave. Take your garage to the next level! Check out Midea.com/us/ to get more info about this game changer today. Old Orchard The beyond-beer space is booming, and Old Orchard is here for it, supplying breweries with fruit ingredients for all your beverage needs: low/no alcohol, hard lemonades, seltzer, cider, and more. Old Orchard has supplied hundreds of industrial customers across 49 states, including nationally and internationally loved brands, so you'll be in good company. More information and free samples are waiting at oldorchard.com/brewer. That's oldorchard.com/brewer. Ss Brewtech Pumps are critical to any advanced homebrewing setup. From mash recirculation to wort transfer, and even for cleaning, a quality pump is a key part of every brew day. The Ss Brew Pump from Ss Brewtech is engineered to tackle even the messiest brew days. Featuring an IP55 water resistance rating, an easy-to-use DIN head with 360-degree rotation, and a flow rate of up to 11 gallons per minute, it has the power to keep your brew day moving. Visit www.SsBrewtech.com/Pump to learn more about how the Ss Brew Pump can upgrade your homebrewery. 2026 Brewers Retreat Tickets are on sale now for the annual Craft Beer & Brewing Brewers Retreat August 23–26 in the hop country of Yakima Valley, Washington. There's nothing like this fantasy homebrew-camp experience, as you brew in small groups led by some of the most inspiring brewers in the world—folks such as Vinnie and Natalie of Russian River, Ben from Breakside, Henry and Adriana of Monkish, Kelsey from North Park, Whitney from Grand Fir, Sean from Lawson's Finest, and more. This year we'll be brewing under the bines at Bale Breaker, and it's sure to be an unforgettable experience. Tickets are on sale now and going fast at brewersretreat.com.

Expo West 2026 made one thing clear: food and beverage brands are racing to add function, but the ones that nail flavor have the best chance of winning. The hosts break down the show's biggest trends, from protein-packed everything to standout brands in candy, beverages, frozen treats, and snacks, while sharing the products and ideas that reinforced a simple truth: in modern CPG, taste still comes first. Show notes: 0:23: Barking Dogs. Plenty Of Protein. Where's The Fiber? Blurring Lines. Sweet (Date) Treats. – The hosts are wiped but loquacious as they break down the biggest themes and trends from Expo West. They highlight the surge of protein across nearly every category – from popcorn, chips, and pretzels to beverages and ice cream – and debate whether some applications make sense today or may become more relevant in the future. Ray emphasizes that taste remains the ultimate test, spotlighting standout brands such as high-protein ice cream maker Protein Pints. The team also notes that added fiber was surprisingly less visible at the show and wonders whether it faces a bigger consumer education hurdle than protein. They examine emerging beverages like spiked prebiotic or probiotic sodas and question their long-term appeal. Beyond functional products, they highlight innovative brands discovered around the show, including crispy jerky chips, soy-based high-protein yogurt, sea moss lemonade, non-alcoholic cocktail alternatives, a modern MSG brand, and date-based candies positioned as better-for-you sweets. Brands in this episode: Khloud, Jam Packed, Lumen, Sky Pop, David, Protein Pints, Manitoba Harvest, Belly Well, Poppi, Pop Sips, Beast, YAY's, Tezza, Bitter Love, Tips, Mother Root, OSIA, Dime MSG, Black Beverly Hills, Oh My Dessert Butter, Sleet Pops, Chara, Benny Bites, Ohum, Kias, Gato, Lasso Jello, Wobbled Jello, Very Lucky, True Dates, Joolie's, Smood, Daddl, Harken Sweets, Farmwell, Quip, House of Joy, Crafty Ramen, Prickly, Fresh Fizz, Leisure, RXBAR, Häagen-Dazs, Ben & Jerry's, Van Leeuwen, Swedish Fish, Mounds, Almond Joy, High Noon

In today's episode I am speaking to the QUEEN of meal prep  again, 2 years later, as a mom and after a health scare which she bounced back like a champ! Maddie is the creator of Let's Eat Plants, an inspiring Channel that helps people eat more plants and particularly prepping meals so that the whole approach is super EASY!!!! What I loved about Maddie was her candid sharing about getting healthier and fitter and creating a system that could help her achieve her goals! Check out our first episode together   https://wellnesswoman.simplecast.com/episodes/lets-eat-plants-with-maddie  This episode is sponsored by Lumen  , the most progressive metabolism switching tracker! Use code Cycleswellness for 20% off  Check out my intro to Lumen on You Tube   @Namawell  https://namawell.com/?ref=LIVELEANHEALTH the BEST cold press juicers , blender and milk makers , on the planet with the revolutionary J2 being the most amazing Bulk juicing champion. To get your Nama juicers and other machines at a discount, use code CHANTAL10 for 10% off!    Want to add some extra nutrients to your morning routine? Check out  @Nuzest  EU /UK  https://www.nuzest.co.uk/LIVELEANHEALTH Get 15% off with my code LIVELEANHEALTH (without worrying about customs)  USA  https://nuzest-usa.com/cycles  Code 15% CYCLESWELLNESS  FOLLOW ME  https://www.instagram.com/liveleanhealth  www.instagram.com/cycleswellness  work with me www.liveleanhealth.com  Stay tuned for our new show: Nutrition Unpacked, with Brenda Davis RD About Maddie  Maddie is the founder of Let's Eat Plants!  Let's Eat Plants encourages anyone who is newly vegan, plant based or curious to learn more about this lifestyle! Maddie herself shares how she is learning new vegan recipes and new ways to cook everyday, and she wants to share those recipes with everyone!  She may not be an expert chef, but she is learning right along with her audience and not shy to trying new things. She thrives to inspire others through her own trials  to make more plant based recipes. Her motto is :"Let's learn more about vegan eating together!"  Follow Maddie on You Tube https://www.youtube.com/@LetsEatPlants  Instagram https://www.instagram.com/lets.eat.plants/    Women's health + holistic living for everyoneWhere wellness meets real lifeFollow, rate & share to support the show

VIDEOSET: https://www.youtube.com/watch?v=NoOlTcsW0I4

Send a textMitochondria in human evolution, climate adaptation, maternal genetics, aging, and disease.TOPICS DISCUSSED:Endosymbiotic theory: Mitochondria arose from oxidative bacteria engulfed by archaea-like hosts, confirmed by phylogenetic analysis.Maternal mtDNA inheritance: Mitochondrial DNA is inherited from the mother, not the father. There are adaptive reasons for this.Haplogroups & adaptation: Tropical lineages tightly couple energy production for efficiency; northern ones uncouple to generate heat.Heteroplasmy & aging: Mixed mutant and normal mitochondria accumulate in cells, eroding energy in high-demand tissues like brain and heart.Bioenergetics in disease: Many common conditions, from Parkinson's to cancer, stem from mitochondrial-nuclear interactions rather than nuclear genes alone.Ketogenic diets: High-fat intake fuels mitochondrial beta-oxidation, which may compensate for brain energy deficits in epilepsy and bipolar disorder.Warburg effect: Cancer cells shift to glycolysis to prioritize biosynthetic building blocks over maximal ATP production.Modern mismatches: Global travel pairs ancestral mtDNA with mismatched diets and climates, raising risks for metabolic dysfunction.ABOUT THE GUEST: Douglas Wallace, PhD is a geneticist and evolutionary biologist who has studied mitochondria for over 50 years. He currently directs the Center for Mitochondrial and Epigenomic Medicine at Children's Hospital of Philadelphia and the University of Pennsylvania.RELATED EPISODE:M&M 260 | Energy Resistance Principle in Life, Healing & Disease | Martin Picard & Nirosha MuruganSupport the showHealth Products by M&M Partners: SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off. Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

Aimar Bretos entrevista a Gisèle Pelicot, que acaba de publicar sus memorias escritas junto con la periodista Judith Perrignon: se trata de 'Un himno a la vida. Mi historia', publicado por la editorial Lumen. Durante casi una década, su exmarido la drogaba con somníferos para organizar violaciones orquestadas.

Aimar Bretos entrevista a Gisèle Pelicot, que acaba de publicar sus memorias escritas junto con la periodista Judith Perrignon: se trata de 'Un himno a la vida. Mi historia', publicado por la editorial Lumen. Durante casi una década, su exmarido la drogaba con somníferos para organizar violaciones orquestadas.

Download Bios: https://we.tl/t-ACU4uP0yDb Sequences Playlist No 284 01.25 Stefan Erbe 'Sometimes' (album The Enemy Inside) https://stefanerbe.bandcamp.com/album/the-enemy-inside 07.41 Stefan Erbe ‘The Enemy Inside' 13.00 Madis ‘Mentes Determinadas :feat Kebu' (album Reflecte) https://madis.bandcamp.com/album/reflecte 20.25 Estas Tonne ‘Fusion' (Live Radio Edit) https://estastonne.bandcamp.com/track/fusion-live-radio-edit 25.03 Antoni Maiovvi ‘In Moonlight' (Death Games) https://spunoutofcontrol.bandcamp.com/album/deathgames 28.36 Antoni Maiovvi 'Slashdance NYC' 33.34 Ash Ra Tempel ‘Reunion' (album Friendship) https://www.discogs.com/sell/list?master_id=764110&format=CD 46.07 Craig Padilla & Marvin Allen ‘Framework' (album (album Unfolding Skies) *** https://padilla-allen.bandcamp.com/album/unfolding-skies 54.27 Mark Jenkins ‘Red Bank' (album Island Earth) www.groove.nl 59.00 Uilises Labaroonie ‘Empathy' (album Cycles de Mémoire) https://cyclicaldreams.bandcamp.com/album/dreams-1 01.04.59 Uilises Labaroonie ‘Doncella' 01.10.14 Dreams Of Wires ‘It's Only Noise' (album Sounds Of Wires ) https://tomorrowthecure.bandcamp.com/album/sounds-of-wires 01.15.31 Dreams Of Wires 'Tomorrow's World' 01.21.16 Erik Wøllo ‘Glass Reverie' (album Snow Tides) www.projekt.com 01.25.12 Erik Wøllo ‘Liminara' 01.31.18 Madison George (feat. Sean O'Bryan Smith) ‘Go With It' (album Marocosm) https://wayfarermusicgroup.bandcamp.com/album/macrocosm 01.35.52 Madison George 'Solstice' 01.40.26 Naviára ‘EARTH Overture' (album Earth) https://naviara.bandcamp.com/album/earth 01.44.27 Naviára ‘The Creation Of Earth/Aminosaur' 01.50.49 Ambient Solstice ‘Breath Of Life' (Narrow Gate) https://wayfarermusicgroup.bandcamp.com/album/narrow-gate 01.58.37 Dino Pacifici-Brannan Lane 'Space Song' (album Imaginary Horizon 2) https://wayfarermusicgroup.bandcamp.com/album/imaginary-horizons-2 02.02.16 Dino Pacifici-Brannan Lane ‘Seabed' 02.05.07 Carla Patullo ‘Our Love Is' (album Nomadica) https://soundcloud.com/carlapatullo 02.09.21 Carla Patullo (feat. Lorenza Ponce, the Scorchio Quartet & Tonality) ‘A Handblown World' 02.13.07 City Of Dawn & Eddy Ruyter 'Labyrinth' (EP Silfira) https://heartdancerecords.bandcamp.com/album/silfira 02.16.17 Free Floating Rotation 'Spring Is On The Doorstep' (EP Seasons) https://eitvrecords.bandcamp.com/album/seasons 02.18.38 C37 ‘I Had A Feeling It Would Come To This' 02.22.06 C37 ‘One By One' 02.26.11 C37 Drawn To An End' 02.29.36 Quiet Resonance ‘Liga Privada' (album Pathways) https://heartdancerecords.bandcamp.com 02.34.40 2002 ‘Overture-The Restless Heart' (album The Wishing Well) https://2002.bandcamp.com/album/the-wishing-well 02.38.27 2002 ‘Moon Lore. 02.43.00 Dirk Serries ‘Oceans Became Light' (album Infinite And Unbound) https://projektrecords.bandcamp.com/album/infinite-and-unbound 02.51.41 Chris Russell ‘Candle Power' (album Lumen) https://chris-russell.bandcamp.com/album/lumen 02.58.32 Chris Russell ‘Particles Of Light' 03.06.37 Dusha ‘Ambience One/Four (album Ambiences) https://tudu.bandcamp.com/album/ambiences 03.12.45 Talst ‘Fray' (album Sewn Into The Infinite Sky) https://winter-light.bandcamp.com/album/sewn-into-the-infinite-sky 03.24.46 Bell Barrow ‘Death Lullaby' (album Saltire'EPK) https://bellbarrow.bandcamp.com/album/saltire 03.29.38 RL Huber ‘Ozarkia' (album Temisto) https://rlhuber.bandcamp.com/album/themisto 03.34.53 RL Huber Themisto' 03.38.04 Kevin Braheny Fortune ‘ Tibetan Bowls Forever 4' (album Tibetan Bowls Forever) https://kevinbrahenyfortune.bandcamp.com/album/tibetan-bowls-forever 03.45.46 In Vitro ‘Radio Spectrum Secrets' (album Radio Spectrum Secrets) https://silentflow.org/release/in-vitro-radio-spectrum-secrets/ 03.51.11 Jonn ‘Endless Night' (EP Glowing Peaks) https://valleyviewrecords.bandcamp.com/album/glowing-peaks 03.54.1 Theddra ‘Inland Sea' (EP Inland Sea) https://marenostrumlabel.bandcamp.com/album/inland-sea Edit ***

Send a textRole of bile acids in cholesterol regulation, digestion & metabolic diseases like diabetes.TOPICS DISCUSSED:Bile acids basics: They enable cholesterol excretion, with about half of bodily cholesterol eliminated this way, and also aid digestion by emulsifying fats to increase enzyme access.Bile production & pathway: Synthesized in liver hepatocytes, bile flows via ducts to the gallbladder for storage or directly to the small intestine; post-meal, cholecystokinin triggers gallbladder contraction for fat emulsification.Regulation of bile acids: Self-regulated to prevent cytotoxicity, as excess can damage cell membranes; insulin and bile acids themselves influence synthesis and transport, with defects in insulin-resistant states.Bile acids in metabolic diseases: Increased synthesis, especially 12-hydroxylated types, occurs in type 2 diabetes and insulin resistance, potentially as an adaptation for better nutrient absorption during perceived scarcity.Gallbladder removal & gallstones: Common due to cholesterol supersaturation forming stones; removal eliminates concentration but preserves bile flow, reducing tolerance for high-fat meals.Bariatric surgery impacts: Procedures like gastric bypass increase circulating bile acids without major synthesis changes, while more extreme ones boost synthesis due to impaired intestinal sensing.Cholesterol homeostasis: Cells tightly regulate membrane cholesterol for fluidity and signaling; most bodily cholesterol is synthesized internally, with LDL receptors key to blood levels.Ongoing research: Haeusler's lab explores manganese's role in metabolism, bile acids in liver inflammation, and insulin's effects on lipoproteins.ABOUT THE GUEST: Rebecca Haeusler, PhD is an associate professor at Columbia University in the departments of medicine and pathology and cell biology, affiliated with the Naomi Berrie Diabetes Center and the Digestive and Liver Diseases Research Center.RELATED EPISODE:M&M 269 | Soybean Oil: Obesity, Fatty Liver Disease, Gut Health, IBS & Colitis | Frances SladekSupport the showHealth Products by M&M Partners: SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off. Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

Take a Network Break! We start with follow-ups on secure browsers and data centers in space, and then sound the red alert about an RCE vulnerability in NLTK. On the news front, Palo Alto Networks acquires a startup that monitors endpoints for malicious packages, browser extensions, scripts, and other threats, Lumen debuts a multi-cloud gateway... Read more »

Take a Network Break! We start with follow-ups on secure browsers and data centers in space, and then sound the red alert about an RCE vulnerability in NLTK. On the news front, Palo Alto Networks acquires a startup that monitors endpoints for malicious packages, browser extensions, scripts, and other threats, Lumen debuts a multi-cloud gateway... Read more »

Take a Network Break! We start with follow-ups on secure browsers and data centers in space, and then sound the red alert about an RCE vulnerability in NLTK. On the news front, Palo Alto Networks acquires a startup that monitors endpoints for malicious packages, browser extensions, scripts, and other threats, Lumen debuts a multi-cloud gateway... Read more »

Send a textHow the body's internal circadian clocks regulate metabolism, energy balance, and health.TOPICS DISCUSSED:Master circadian clock in the brain: Light detection via retina entrains the suprachiasmatic nucleus, which coordinates body-wide rhythms; intrinsic period slightly deviates from 24 hours, allowing seasonal flexibility.Peripheral clocks in organs: Nearly all cells have autonomous clocks; liver and fat clocks rapidly adjust to feeding time, while brain clock aligns more tightly to light.Clock mutations and metabolism: Disrupting core clock genes (e.g., CLOCK, BMAL1) causes obesity, liver fat accumulation, and impaired insulin secretion without hyperinsulinemia.Timing of food intake: Eating the same high-fat calories during rest phase causes more weight gain than during active phase due to differences in energy dissipation.Modern disruptions (jet lag, shift work, blue light): Create desynchrony between brain and peripheral clocks, contributing to metabolic issues; late-night eating impairs glucose handling.Critical illness & feeding: Tube feeding at night (opposite natural cycle) induces rapid insulin resistance, highlighting mismatch costs.Hormone rhythms: Testosterone, glucocorticoids, and others peak at specific times; misalignment affects stress, reproduction, and metabolism.Weight loss drugs & maintenance: GLP-1 drugs reduce intake effectively, but regain involves neuroendocrine adaptations tied to brain clock pathways.ABOUT THE GUEST: Joseph Bass, MD, PhD is Chief of Endocrinology, Metabolism and Molecular Medicine at Northwestern University Feinberg School of Medicine, Director of the Center for Diabetes and Metabolism, and a leading researcher who pioneered the link between circadian clock genes and metabolic disorders including obesity and diabetes.RELATED EPISODE:M&M 237 | Circadian Biology: Genetics, Behavior, Metabolism, Light, Oxygen & Melatonin | Joseph TakahashiSupport the showHealth Products by M&M Partners: SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off. Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

Editorial  Las conversiones del islam al catolicismo han aumentado en los últimos años, pero requieren superar muchos obstáculos por razones religiosas, políticas, sociales y familiares. A menudo, las estructuras eclesiales no cuentan con la experiencia o la formación necesaria para facilitar estas conversiones, por lo que, en 2024, se creó una red de apoyo a los conversos. La Red San Nicolás Tavelić para Católicos Moriscos (TavNet) es una red misionera católica dirigida por laicos que proporciona asistencia a nuevos católicos que viven en comunidades o sociedades de mayoría musulmana. Noticias internacionales  Portugal: El Santuario de Fátima superó los 6 millones de peregrinos  EE. UU.: El Arzobispo de Nueva York celebra su primera Misa en español  México: Buscan declarar el 25 de marzo como “Día de la Vida”  Europa: Iniciativa para rezar por la paz durante la Cuaresma 2026 Noticias nacionales  Las hermandades se preparan ya para la Semana Santa  Al menos 50 adultos más quieren ser cristianos en Getafe  San Sebastián recuperará las procesiones de Semana Santa Noticias de la Santa Sede  Conmemoración del 97° aniversario de los Pactos de Letrán  V Encuentro Internacional de Corales en el Vaticano  Catequesis sobre la Constitución Lumen gentium

Send a textGene regulation through RNAs, the neurobiology of opioid addiction, and how psychedelics affect drug-seeking by modulating inflammation and plasticity. Not medical advice.TOPICS DISCUSSED:Gene regulation basics: DNA transcribes to RNAs, including non-coding types like microRNAs that inhibit mRNA translation into proteins, influencing up to 60% of the proteome.Non-coding RNAs in neuroplasticity: MicroRNAs and circular RNAs regulate synaptic changes, with activity-induced ones like miR-485-5p linked to rapid responses in drug cue memory and addiction reinforcement.Opioid addiction models: Rats self-administer heroin or fentanyl via levers, showing compulsive seeking; fentanyl's higher potency drives faster learning but similar long-term effects to heroin when doses are equated.Differences between opioids: Heroin and fentanyl both activate mu-opioid receptors for euphoria and dopamine release, but fentanyl lingers longer; no major behavioral differences in seeking once potency is matched.Psilocybin's effects on addiction: A single psilocybin dose post-abstinence reduces heroin-seeking in rats by dampening neuroinflammation in brain regions like the nucleus accumbens and prefrontal cortex.Brain Inflammation: Opioids induce pro-inflammatory changes via cytokines like IL-17A and pathways like TNF-alpha, leading to glial activation and blood-brain barrier leaks; psilocybin counters this.MicroRNA biomarkers: Blood microRNAs reflect gene expression patterns tied to disease states, with potential to predict opioid relapse risk, treatment response, or neonatal withdrawal severity non-invasively.Future research: Ongoing work links psilocybin's serotonin 2A activation to anti-inflammatory gene changes, plus human studies on microRNAs for personalized addiction treatments.ABOUT THE GUEST: Stephanie Daws, PhD is an associate professor at Temple University in the Center for Substance Abuse Research and Department of Neurosciences, where she researches mechanisms of drug-seeking behavior with a focus on opioids and psychedelics.RELATED EPISODE:M&M 2 | Psilocybin, LSD, Ketamine, InflamSupport the showHealth Products by M&M Partners: SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off. Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

Send a textWelcome back to Making Data Simple, where we explore how data-driven strategies ignite innovation and transform businesses. In this exciting episode, we sit down with Marco Rota, VP of Strategic Technology Alliances at Lumen Technologies, whose incredible journey spans from the glitz of Hollywood to leading-edge telecommunications. Tune in as Marco reveals how embracing a vibrant culture, drawing on lessons from the entertainment industry, and championing new technologies can propel teams and organizations to new heights of success. Get ready for an inspiring, behind-the-scenes look at how “culture eats strategy for breakfast”—and why that's a game-changer for your organization, too!01:47 – Meet Marco RotaMarco shares his background and how his career path took him from the dynamic world of Hollywood to a leadership role at Lumen Technologies. He underscores his passion for storytelling, collaboration, and innovation—elements that continue to shape his work in tech.03:35 – Learnings from HollywoodDrawing on Hollywood's fast-paced environment, Marco highlights the importance of creative thinking and adaptability. He explains how these traits help push organizations to stay ahead of disruption and continually evolve, just like the film industry does to meet audience demands.10:56 – Transitioning to Lumen TechnologiesMarco describes his shift from entertainment into the telecommunications and technology space. He emphasizes the parallels between Hollywood and tech—both thrive on communication, audience engagement, and cutting-edge production processes.15:55 – What IS Lumen TechnologiesMarco explains Lumen's core mission: powering next-generation connectivity, cloud, edge computing, and security solutions. By marrying technology services with an innovative culture, Lumen seeks to help organizations accelerate data-driven transformation.18:29 – Culture versus TechnologyAn organization's culture can be its greatest asset—or its biggest hurdle. Culture “eats strategy for breakfast” because fostering collaboration, trust, and continuous learning is what truly drives successful technology initiatives forward.24:20 – The Management SystemMarco talks about the framework for leadership and team alignment at Lumen, which integrates vision, purpose, and measurable goals. This system ensures that cultural values and strategic objectives reinforce each other—resulting in cohesive, energized teams ready to tackle the biggest challenges in tech.Linkedin: linkedin.com/in/marcorotapixWebsite: https://www.lumen.com/en-us/home.htmlWant to be featured as a guest on Making Data Simple?  Reach out to us at almartintalksdata@gmail.com and tell us why you should be next.  The Making Data Simple Podcast is hosted by Al Martin, WW VP Technical Sales, IBM, where we explore trending technologies, business innovation, and leadership ... while keeping it simple & fun. #MakingDataSimple #CultureEatsStrategy #DataInnovation #DigitalTransformation #TechLeadership #PodcastEpisode #HollywoodToTech #LumenTechnologies #BusinessInsights #InspirationWant to be featured as a guest on Making Data Simple? Reach out to us at almartintalksdata@gmail.com and tell us why you should be next. The Making Data Simple Podcast is hosted by Al Martin, WW VP Technical Sales, IBM, where we explore trending technologies, business innovation, and leadership ... while keeping it simple & fun.

Send a textWelcome back to Making Data Simple, where we explore how data-driven strategies ignite innovation and transform businesses. In this exciting episode, we sit down with Marco Rota, VP of Strategic Technology Alliances at Lumen Technologies, whose incredible journey spans from the glitz of Hollywood to leading-edge telecommunications. Tune in as Marco reveals how embracing a vibrant culture, drawing on lessons from the entertainment industry, and championing new technologies can propel teams and organizations to new heights of success. Get ready for an inspiring, behind-the-scenes look at how “culture eats strategy for breakfast”—and why that's a game-changer for your organization, too!01:47 – Meet Marco RotaMarco shares his background and how his career path took him from the dynamic world of Hollywood to a leadership role at Lumen Technologies. He underscores his passion for storytelling, collaboration, and innovation—elements that continue to shape his work in tech.03:35 – Learnings from HollywoodDrawing on Hollywood's fast-paced environment, Marco highlights the importance of creative thinking and adaptability. He explains how these traits help push organizations to stay ahead of disruption and continually evolve, just like the film industry does to meet audience demands.10:56 – Transitioning to Lumen TechnologiesMarco describes his shift from entertainment into the telecommunications and technology space. He emphasizes the parallels between Hollywood and tech—both thrive on communication, audience engagement, and cutting-edge production processes.15:55 – What IS Lumen TechnologiesMarco explains Lumen's core mission: powering next-generation connectivity, cloud, edge computing, and security solutions. By marrying technology services with an innovative culture, Lumen seeks to help organizations accelerate data-driven transformation.18:29 – Culture versus TechnologyAn organization's culture can be its greatest asset—or its biggest hurdle. Culture “eats strategy for breakfast” because fostering collaboration, trust, and continuous learning is what truly drives successful technology initiatives forward.24:20 – The Management SystemMarco talks about the framework for leadership and team alignment at Lumen, which integrates vision, purpose, and measurable goals. This system ensures that cultural values and strategic objectives reinforce each other—resulting in cohesive, energized teams ready to tackle the biggest challenges in tech.Linkedin: linkedin.com/in/marcorotapixWebsite: https://www.lumen.com/en-us/home.htmlWant to be featured as a guest on Making Data Simple?  Reach out to us at almartintalksdata@gmail.com and tell us why you should be next.  The Making Data Simple Podcast is hosted by Al Martin, WW VP Technical Sales, IBM, where we explore trending technologies, business innovation, and leadership ... while keeping it simple & fun. #MakingDataSimple #CultureEatsStrategy #DataInnovation #DigitalTransformation #TechLeadership #PodcastEpisode #HollywoodToTech #LumenTechnologies #BusinessInsights #InspirationWant to be featured as a guest on Making Data Simple? Reach out to us at almartintalksdata@gmail.com and tell us why you should be next. The Making Data Simple Podcast is hosted by Al Martin, WW VP Technical Sales, IBM, where we explore trending technologies, business innovation, and leadership ... while keeping it simple & fun.

How will Lumen's recent EMEA divestiture impact your organization? The expansion and retraction of individual providers' networks that we see with Lumen's sale of its EMEA assets to COLT allows Lumen to focus on its North American core, while utilizing Colt's expanded footprint to serve international clients. In this 12-minute episode of Staying Connected, Tony Mangino and Frank Zagrodnik from TC2 are joined by LB3's Deb Boehling to outline potential impacts of supplier asset divestitures, some specifics on Lumen's recent EMEA divestiture, and how enterprises can manage these changes. If you would like to learn more about our experience in this space, please visit our Network Services Transactions and Technology Consulting and Strategy Development webpages.   

Our featured guest this monthCody Cornell, CEO and founder of Swimlane, interviewed by Frank Victory. News from Great American Beer Festival, Lumen, Zvelo, RADICL, Ping Identity, Red Canary and a lot more! Welcome back to the Colorado = Security podcast, where today we're trading the icebreakers of Antarctica for the high-stakes world of global SecOps! Join us as Cody Cornell, the visionary CEO of Swimlane, reveals how he pivoted from the front lines of the Coast Guard to building the future of security automation. It's time to find out if your organization is a fortress of governance or just a glass house waiting for a stone—let's dive in!https://www.linkedin.com/in/codycornell/https://swimlane.com/https://www.linkedin.com/in/frank-victory/https://snowfroc.com/ Come join us on the Colorado = Security Slack channel to meet old and new friends. Sign up for our mailing list on the main site to receive weekly updates - https://www.colorado-security.com/. If you have any questions or comments, or any organizations or events we should highlight, contact Alex and Robb at info@colorado-security.com This week's news: Great American Beer Festival relocates from downtown Denver Colorado now has 6 million people, even amid slowing population growth Denver-area telecom completes $5.75B cash sale to AT&T Louisville tech company nears public offering Energy, data center tax break debates set to kick off in the Colorado legislature this week Agentic AI Security Exposes the Limits of Zero Trust Swimlane Introduces Fleet of AI Agents and Agent-Builder RADICL Secures $31M to Accelerate the Future of Autonomous Cyber Defense for SMBs What is Zero-Knowledge Biometric Authentication? A Simple Guide for Security Teams Go jump in a lake: Measuring the data lake effect on your SIEM | Red Canary Upcoming Events: Check out the full calendar CSA Colorado - Enabling AI: Rules of the Road - 2/17 ISSA COS - February Trivia Night - 2/19 ISACA Denver - February Meeting with the IIA - 2/19 ISC2 Pikes Peak - 2/25 Denver ISSA - AI/ML Special Interest Group - 2/25 View our events page for a full list of upcoming events * Thanks to CJ Adams for our intro and exit! If you need any voiceover work, you can contact him here at carrrladams@gmail.com. Check out his other voice work here. * Intro and exit song: "The Language of Blame" by The Agrarians is licensed under CC BY 2.0

Send a textThe biology of fat tissue, estrogen's role in metabolism and health, and how exercise interacts with these processes, especially during menopause.TOPICS DISCUSSED:Adipose tissue basics: White fat primarily stores energy in large lipid droplets, while brown fat burns fatty acids for heat via high mitochondrial density; white fat can “brown” with exercise or certain foods like capsaicin.Fat distribution & health: Subcutaneous fat (under skin) is more insulin-sensitive and less problematic than visceral fat (around organs), which links to metabolic issues; females store more subcutaneously pre-menopause, shifting to visceral post-menopause.Estrogen signaling: Estradiol binds nuclear and membrane receptors to regulate gene expression and mitochondrial function; it enhances insulin sensitivity and browning in fat cells, with receptors like ER-alpha feminizing fat distribution.Fat storage: Fat cells enlarge (hypertrophy) more than multiply in obesity, leading to hypoxia, inflammation, and insulin resistance; excess fatty acids spill to liver and muscle, worsening metabolic dysfunction.Menopause effects: Estrogen drop causes visceral fat gain, reduced energy expenditure, insulin resistance, and higher metabolic disease risk; symptoms include hot flashes and reduced exercise motivation, modeled in rodents via ovary removal.Exercise & estrogen links: Exercise boosts estrogen receptor expression and mitochondrial density in fat, mimicking estrogen's browning effects; synergism may explain reduced exercise responsiveness post-menopause.Brain-fat connections: Estrogen in the nucleus accumbens influences exercise motivation and fat browning; manipulations there alter running behavior and adipose metabolism in rodents.ABOUT THE GUEST: Victoria Vieira-Potter, PhD leads a lab at the University of Missouri, studying how estrogen and exercise influence adipose cells.RELATED EPISODE:M&M 174 | Adipose Tissue & Body Fat: Obesity, Insulin, Leptin, Fertility, Weight Loss & GLP-1 Drugs | Sean HartigSupport the showHealth Products by M&M Partners: SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off. Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

Beat Migs! We ran into our friend Kelly Hanson on Lumen field and had to talk to her.

Elle est invoquée "sous les titres d'avocate, d'auxiliatrice, de secourable, de médiatrice" (Lumen gentium). Régis Burnet nous propose une émission de théologie fondamentale sur la Vierge Marie, un exercice simplifié par le Frère Philippe Jeannin, dominicain, et Jean-Pierre Caloz, Oblat de Marie Immaculée. Emission du 7 décembre 2008.

Send us a textThe brain's mysterious claustrum region, its role in cognitive flexibility, and how substances like alcohol and psychedelics affect neural circuits and behavior. Not medical advice.TOPICS DISCUSSED:Cerebral cortex structure: Described as a six-layered structure with pyramidal neurons and inhibitory interneurons; information flows between layers and regions to process sensory input and enable complex behaviors.Claustrum anatomy & connectivity: A sheet-like subcortical structure embedded in white matter, bidirectionally connected to cortical areas, especially prefrontal regions in rodents, with broader connections in primates and humans suggesting an integrative role.Claustrum function in cognition: Experiments show claustrum activation during task switches from easy to demanding modes, synchronizing cortical networks via inhibition and rebound excitation, potentially enabling flexible behavior.Mouse models in neuroscience: Mice are used for genetic tractability to manipulate and monitor specific circuits, revealing claustrum's role in vigilance tasks but not simple ones.Alcohol's effects on brain circuits: Chronic alcohol promotes inflexible behaviors by altering striatal interneurons and inhibitory inputs, leading to compulsive drinking despite aversive consequences.Psychedelics & brain networks: Psilocybin disrupts default mode and other networks, inhibits claustrum via serotonin 1B receptors, with effects persisting 24 hours, possibly contributing to therapeutic benefits.Evolution of claustrum: Connectivity expands from rodents to humans, shifting from cognitive-specific to broader network control, including anti-correlated states like default mode versus task-engaged.Integration of claustrum & basal ganglia: Claustrum funnels prefrontal signals to basal ganglia for action selection; alcohol may impair this, exacerbating inflexibility in addiction.ABOUT THE GUEST: Brian, PhD is a professor in the Department of Pharmacology and Physiology at the University of Maryland School of Medicine, where he leads a neuroscience lab studying brain circuits underlying flexible and inflexible behaviors using mouse models, with a focus on alcohol use disorder.Support the showHealth Products by M&M Partners: SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off. Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

Tras el éxito de ventas de 'La península de la casas vacías' (Siruela), David Uclés vuelve a la Biblioteca Antonio Martínez Asensio de Hoy por Hoy con 'La ciudad de las luces muertas' (Destino), galardonada con el Premio Nadal 2026. El autor jienense convierte la ciudad de Barcelona en un espacio cultural y vital de todos los tiempos en el que se mezclan personajes y espacios reales tras un apagón provocado por un deseo de la escritora Carmen Laforet. Lean este libro sin ninguna pretensión más que el disfrute. Intentar entender el realismo mágico está contraindicado de toda la vida. Y David Uclés nos trajo su libro , pero también una donación para nuestra biblioteca radiofónica , en su caso "'El sueño de la aldea Ding' de Yan Lianke (Automática Editorial). Pero antes de la entrevista, nuestro bibliotecario Antonio Martínez Asensio, que el domingo nos contará en una hora 'El fantasma de la ópera" de Gaston Leroux (Valdemar), nos relató en tres minutos otro clásico:  'Mr Gwyn'  de Alessandro Baricco (Anagrama).  Las novedades del día las trajo Pepe Rubio  y fueron 'Republicanas: Revolución, guerra y exilio de nueve diputadas' de Miguel Ángel Villena (Tusquets) y  'Arca' de Ricardo Menéndez Salmón (Seix Barral) . Sumamos el libro perdido de  Pascual Donate  'Leviatán o la ballena' de Philip Hoare (Ático de los libros) . Homenajeamos a nuestro compañero y escritor Carlos Hernández , recientemente fallecido, recomendando  'Los campos de concentración de Franco' de Carlos Hernández De Miguel (Ediciones B). Y finalmente llegaron las donaciones de nuestros oyentes: ´Barrio de maravillas" Rosa Chacel (Lumen),  'Las gratitudes' de Delphine De Vigan (Anagrama) y  'Lonesome dove (Paloma Solitaria)' de Larry McMurtry (Valdemar) . Disfruten de todas las lecturas. 

Send us a textPharmacology & neurobiology of psychedelics & MDMA, focusing on isomers, sex-specific effects, and mechanisms in animal models. Not medical advice.TOPICS DISCUSSED:Biased agonism: Different drugs activate the same receptor (e.g., 5-HT2A) but trigger varied intracellular pathways, explaining why LSD is psychedelic while similar lisuride is not.Enantiomers & isomers: Mirror-image versions of drugs like MDMA (S and R forms) and LSD (four isomers) often produce distinct effects; only one LSD isomer is psychedelic, for example.MDMA isomer effects: S-MDMA induces stronger head twitches (psychedelic proxy) via serotonin release, and increases dendritic spines in male mice but not females; R-MDMA has somewhat different effects.Sex-specific drug responses: In mice, females show stronger psychedelic effects (head twitches) from psilocybin and DOI at the same dose, but males exhibit greater post-acute benefits like reduced opioid withdrawal.Psilocybin in opioid addiction models: A single dose reduces place preference for oxycodone and withdrawal symptoms in male mice more than females, with opposite spine density effects in reward-related brain areas.Mechanisms beyond 5-HT2A: Psychedelics involve other receptors like metabotropic glutamate receptors, forming dimers with 5-HT2A to enable dual signaling pathways; effects in subcortical regions like nucleus accumbens are 5-HT2A-independent.Clinical implications: Street MDMA may vary in S/R ratios, affecting experiences; clinical trials often use racemic mixtures without weight-adjusted dosing, potentially missing sex differences.ABOUT THE GUEST: Javier Gonzalez-Maeso, PhD is a professor of pharmacology and toxicology at Virginia Commonwealth University, with a PhD in medicine from Spain focused on G-protein coupled receptors and human brain studies in depression and addiction.RELATED EPISODE:M&M 230 | Psilocybin & MDMA: Inflammation, Stress & Brain-Body Communication | Michael WheelerSupport the showHealth Products by M&M Partners: SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off. Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

February 4th – Show 1105The ChatLee shared updates about his new job, creating social media content and engaging with owners through Facebook. He emphasized his proactive approach to preparing for the park’s reopening on March 1st. He also told us about his. new car, highlighting its advanced technology and voice commands, while expressing concern about potential distractions. T discussed working on a story with the help of ChatGPT, which she named “Lumen,” and shared her experience with the AI’s feedback. Snug mentioned using ChatGPT for a screenplay and shared a paragraph to improve its feedback and make it less fawning. Emergency Questions: If you had to rename your hometown, what would you call it? If you could choose any six people to be the pallbearers at your funeral, who would you choose? If you could give a single piece of advice to the film industry, what would you say? Who would be on your Mount Rushmore of fictional bullies? TV & MoviesWonder Man Greenland 2 Fackham Hall Fallout Colin From Accounts Linktree Discord: https://discord.gg/7ndTXDhNC5 a Facebook message A blog comment below @ us on Twitter Why not surprise us with an MP3 in an email to twoguys@snugradio.co.uk Please take some time to show us your love by reviewing us on ITunes. We welcome ALL comments The Snug is an affiliate of Amazon Music   Snug StatsMusic This ShowElf Maf & Lee – Mony Mony Tamara Sings – Tamara Writes & AI Sings – Sweety Sweety Sweets Cover Version SandwichSingle Ladies Join us every Wednesday from 18:30 (UK time) See you then…and have a Snuggly week.

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Pol Guasch aparca la ficción para relatarnos, en 'Reliquia'  (Anagrama),  su duelo por el suicidio de su padre. Narra todo un proceso de diez años que culmina con la decisión de escribir y publicar la novela.  Va encajando con maestría todas las piezas que conforman el puzle de una muerte violenta, que nadie te explica, que ves venir, pero a la vez no esperas, y , lo más importante, que no se olvida.  Pol nos donó además para nuestra biblioteca  'Cerca del corazón salvaje" de Clarice Lispector (Siruela), de la misma autoría de Clarice Lispector  la novela que va a contar Antonio Martínez Asensio en 'Un libro, una hora', 'La hora de la estrella' . Pero antes, nuestro bibliotecario nos contó en tres minutos “Bartleby, el escribiente” de Herman Melville (Alianza) . Las novedades las trajo Pepe Rubio y fueron 'Textos vivos-Notas de un reencuentro" de José Carlos Mainer (Renacimiento ) y 'Noche blanca' de Úrszula Honek (Lumen). El libro abandonado y rescatado por Pascual Donate fue  'Vida Àvida'  de Ángel Guinda (Olifante Editorial). Finalmente los oyentes donaron: 'Último barco' Domingo Villar (Siruela) , 'He visto ballenas' de Javier de Isusi (Astiberri) y 'Vanguardia es una mujer' de Clara de Frutos (Norma Editorial) . Y terminamos la hora con lo que Pol Guasch, el autor invitado, estaba leyendo en ese momento "Un deseo desmesurado de amistad" de Hélène Giannnecchini (Anagrama) 

On this episode of the Established Podcast, we hear from Cornel Amariei, the CEO of .lumen. Cornel chats about deep tech that guides users using haptics.     Get Involved! Founders, investors, startup teams, entrepreneur support organizations (ESOs), and innovators, we invite you to join the Established Network, our digital hub where creativity, capital, and collaboration collide. https://established.network    Watch the episode on the Established YouTube Channel at: https://soty.link/ESTYouTube   Thank you for listening, and as always, please check out the Established website and subscribe to the newsletter at: www.est.us    Subscribe to the Established podcast: https://theestablishedpodcast.com/     Startup of the Year helps diverse, emerging startups, founding teams, and entrepreneurs push their companies to the next level. We are a competition, a global community, and a resource. Startup of the Year is also a year-long program that searches the country for a geographically diverse set of startups from all backgrounds and pulls them together to compete for the title of Startup of the Year. Check out Startup of the Year at: www.startupofyear.com   Established is a consultancy focused on helping organizations with innovation, startup, and communication strategies. It is the power behind Startup of the Year. Created by the talent responsible for building the Tech.Co brand (acquired by an international publishing company), we are leveraging decades of experience to help our collaborators best further (or create) their brand & accomplish their most important goals. Check out Established at: www.established.us Connect with us on X (formerly Twitter) - @EstablishedUs    Connect with us on Facebook - facebook.com/established.us  

¡Emprendeduros! En este episodio nos complace presentarles una actualización de Emprendeduros Ventures, el fondo de los Emprendeduros hecho DE la comunidad, PARA la comunidad. Revisamos las inversiones hechas por el fondo (Liv y Lumen) y en donde se encuentran las empresas en las que hemos invertido. Nos dan también sus metas a corto, mediano y largo plazo. Para mas información sobre el fondo visita: http://www.emprendedurosventures.com Mandanos tu proyecto: fondo@emprendeduros.com Instagram de Lumen: https://www.instagram.com/meetlumen/ Sitio de Lumen: https://morelumen.com/ Instagram de Liv: https://www.instagram.com/my.liv.place/ YouTube de Liv: https://www.youtube.com/@liv.marketplace Sitio de Liv: https://www.liv.place/ Toma el control de tu tiempo y estudia tu universidad en línea avalada por la SEP en Hybridge: https://hybridge.education/universidad-en-linea-sptf-emprendeduros __________________________________________________________________________________________________ Obtén 3 meses gratis de Notion for Business, que incluye IA: https://ntn.so/%5Bgenuina%5Demprendeduros Hosted by Simplecast, an AdsWizz company. See https://pcm.adswizz.com for information about our collection and use of personal data for advertising.

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Send us a textThe AMP kinase pathway's role in cellular energy sensing, nutrient allocation, and its connections to health practices like fasting, exercise, and diet.TOPICS DISCUSSED:Cellular energy basics: ATP/ADP/AMP as energy currencies; AMP kinase activates on low ATP to conserve and redirect resources, like a budget manager.AMP kinase mechanics: Heterotrimeric enzyme phosphorylating 100+ substrates; localizes dynamically in cytosol, mitochondria, nucleus to integrate signals.Nutrient detection: Senses fatty acids in fasting/ketogenic states, boosting fat oxidation and mitochondria independent of energy drops.Fasting/exercise impacts: Elevate AMP kinase for mitophagy, better fuel switching; mimic historical scarcity absent under modern constant feeding.mTOR relationship: AMP kinase inhibits mTOR to stop growth in low energy states; feedback loop disrupted by abundance, promoting tissue buildup.Disease links: Low AMP kinase in obesity/diabetes reduces flexibility; activation prevents cancer but may aid tumor survival in therapy.Drugs/diets: Metformin and GLP-1s like Ozempic activate AMP kinase for glucose control/weight loss; ketogenic diets activate at intermediate levels for fat efficiency.ABOUT THE GUEST: Gregory Steinberg, PhD is a Professor of Medicine at McMaster University and co-directs the Centre for Metabolism, Obesity, and Diabetes Research, focusing on cellular energy sensors like AMP kinase.RELATED EPISODE:M&M 260 | Energy Resistance Principle in Life, Healing & Disease | Martin Picard & Nirosha MuruganSupport the showHealth Products by M&M Partners: SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code TRIKOMES for 20% off. Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

Seahawks fans are being instructed to not fly drones near Lumen Field during the NFC Championship on Sunday. Sound Transit announced a new opening date for light rail. // An anti-ICE agitator in Minnesota dared Attorney General Pam Bondi to arrest him… and he got arrested. Democrats continue to lie about the 5-year-old boy that was ‘detained’ by ICE in Minnesota. // Guest: Jason Chaffetz breaks down the SAVE Act and the zombie filibuster, and previews his new radio show starting Sunday on Seattle Red.

In this episode of LIGHT TALK, The Lumen Sisters interview lighting designers/programmers, Aria Hailey and Erica D. Hayes.   In this episode, the Lumen family present a very special LIGHT TALK focusing on Women and Lighting. Join Aria, Erica, Kelsey, and Ellen as they discuss: The challenge of being a woman in the industry; What its like to be the only woman on the bus; Opening doors; Great women designers working in theatre and the concert industries; Opening new pathways; How to get the courage to step in; Being mistaken for another person on the show; Is it important to bring a women's perspective to lighting art?; Working with advocates; "Women in Lighting" LDI panels; Networking connections; Teaching overseas; The future of AI in programming; Dream AI tools; "Claude"... Making a programmer's life easier; Dream jobs; and Advice for the next generation of women in lighting design.  Nothing is Taboo, Nothing is Sacred, and Very Little Makes Sense.

Ted's Meat & Potatoes

Lumen recently announced the migration of its legacy "Control Center" customer portal to the newly branded "Lumen Connect".  In this 8-minute episode of Staying Connected, TC2's Theresa Knutson joins Tony Mangino to cover what's changing with this rollout, why Lumen is making these moves now, and what steps your team should be taking. If you would like to learn more about our experience in this space, please visit our IT Cost Management webpage. 

Send us a textHow industrial farming, seed oils, soy, and pesticides impact food nutrition and health. Not medical advice.TOPICS DISCUSSED:Soy's rise in farming: Originating from paint uses and wartime chemicals, soy became dominant due to subsidies and large-scale farming practices, but introduces high PUFAs, phytoestrogens, and pesticides into animal feeds.Feed's impact on eggs: Chicken feeds high in soy and corn raise linoleic acid levels in eggs compared to low-soy alternatives; low-PUFA eggs improve digestibility for many.PUFAs & health effects: Feeding PUFAs fattens animals faster and disrupts human gut lining and metabolism; body fat composition changes take time, linking to chronic issues like low energy.Phytoestrogens in soy: These compounds pass into animal products, affecting estrogen signaling and gut health; mainstream nutrition often overlooks their risks despite historical low exposure.Dairy variations: Raw milk retains lactoferrin for iron regulation and gut support, plus enzymes and probiotics destroyed in pasteurization; it may resolve dairy intolerances for some.Regenerative farming model: Armstrong's cooperative emphasizes traditional feeds to “resaturate” foods, reducing PUFAs; supports small farms amid declining farm numbers.Ancestral diets insight: Traditional diets vary but share low PUFA levels, avoiding modern chronic illnesses tied to industrial fats.ABOUT THE GUEST: Ashley Armstrong, PhD co-founded Angel Acres Farm in Michigan and now runs Nourish Food Club, a cooperative of small farms producing low-PUFA, soy-free animal foods.RELATED EPISODE:M&M 273: Nutrition Content of Animal & Plant Foods: Beef, Plant-Based Meat, Raw vs. Processed MilkSupport the showHealth Products by M&M Partners: SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code TRIKOMES for 20% off. Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

Steiny & Guru give their final speeches and predictions for the big game in Seattle and give the REAL about the 49ers. They also chat with Hall of Fame QB Warren Moon.

Send us a textHow individuals vary in responses to carbs, fibers, and fats.TOPICS DISCUSSED:Personalized health profiling: Snyder's lab sequences genomes and measures molecules from blood, urine, and microbiomes to detect diseases early, emphasizing data-driven discovery over assumptions.Fiber variations and effects: Responses to dietary fibers vary individually, with microbiome playing a key role.Glycemic responses to carbs: People spike differently to foods like rice, potatoes, or bread; tied to insulin resistance subtypes in muscles, liver, or pancreas.Type 2 diabetes heterogeneity: 90% of diabetes cases are type 2 with subtypes like muscle or hepatic resistance; triggers include genetics and infections, with prediabetes often undetected.Continuous glucose monitors (CGMs): Affordable tools measure glucose every five minutes, revealing personal food triggers; spikes link to risks like cardiovascular disease and cancer.Lipidomics: Lipids are diverse, serving as energy sources, structural components, and signaling molecules; understudied but key in metabolism and gene expression.Maternal health & pregnancy: Metabolomics shows thousands of changes, including hormone shifts; cord blood analysis reveals fetal nutrient use and drug transfers, with markers for preterm birth or healthy outcomes.Future research: Exploring epigenetic changes in diabetes, personalized nutrition mitigation, and digital markers from wearables for mental health tied to diet and gut-brain axis.ABOUT THE GUEST: Michael Snyder, PhD is the Stanford W. Ascherman Professor of Genetics and former chair of the Department of Genetics at Stanford University School of Medicine, where he directs the Center for Genomics and Personalized Medicine.Support the showHealth Products by M&M Partners: SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code TRIKOMES for 20% off. Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

China pursues a strategy of strategically “beggaring thy neighbor” – but what can we do to fight it? Plus, President Trump unleashes agricultural subsidies, and Jasmine Crockett for Texas Senate? Ep.2330 - - - Click here to join the member-exclusive portion of my show: https://bit.ly/3WDjgHE - - - Facts Don't Care About Your Feelings - - - Today's Sponsors: Perplexity - Ask anything at https://pplx.ai/benshapiro and try out their new AI-powered web browser Comet at https://comet.perplexity.ai/ PureTalk - Switch to PureTalk and start saving today! Visit https://PureTalk.com/SHAPIRO Lumen - Head to https://lumen.me/SHAPIRO to get an additional 15% off your Lumen. HIYA - Receive 50% off your first order. Go to https://hiyahealth.com/SHAPIRO Helix - Go to https://helixsleep.com/ben for an exclusive offer. PreBorn! - Donate today and help save babies from abortion at https://preborn.com/BEN or dial #250 keyword 'BABY' - - - DailyWire+: Once a year, every year, we give you our best deal of the year. And it's happening right now. DailyWire+ memberships are 50% off. https://getdwplus.com/blackfridayBENYT Finally, Friendly Fire is here! No moderator, no safe words. Now available at https://www.dailywire.com/show/friendly-fire Get your Ben Shapiro merch here: https://bit.ly/3TAu2cw - - - Socials: Follow on Twitter: https://bit.ly/3cXUn53  Follow on Instagram: https://bit.ly/3QtuibJ  Follow on Facebook: https://bit.ly/3TTirqd  Subscribe on YouTube: https://bit.ly/3RPyBiB - - - Privacy Policy: https://www.dailywire.com/privacy Learn more about your ad choices. Visit podcastchoices.com/adchoices

After Defense Secretary Pete Hegseth orders a strike on a narcoterrorist boat, Democrats accuse him of war crimes; the White House prepares a pardon for a major convicted drug trafficker; and the GOP faces down a tough Congressional election in Tennessee. Ep.2325 - - - Click here to join the member-exclusive portion of my show: https://bit.ly/3WDjgHE - - - Facts Don't Care About Your Feelings - - - Today's Sponsors: Perplexity - Ask anything at https://pplx.ai/benshapiro and try out their new AI-powered web browser Comet at https://comet.perplexity.ai/ PureTalk - Switch to PureTalk and start saving today! Visit https://PureTalk.com/SHAPIRO Helix Sleep - Go to https://helixsleep.com/ben for an exclusive offer. Shopify - Sign up for your $1-per-month trial and start selling today at https://Shopify.com/shapiro Lumen - Head to https://lumen.me/SHAPIRO to get an additional 15% off your Lumen. Balance of Nature - Go to https://balanceofnature.com/pages/podcasters to get a FREE Variety Snack Pack plus a FREE Preferred Customer membership with your first set of Balance of Nature supplements. Daily Wire Shop - Go to https://dailywire.com/shop today. Kalshi - Visit https://kalshi.com/shapiro to see live prediction markets and sign up today to trade on the outcomes that matter most to you. - - - DailyWire+: Once a year, every year, we give you our best deal of the year. And it's happening right now. DailyWire+ memberships are 50% off. https://getdwplus.com/blackfridayBENYT Finally, Friendly Fire is here! No moderator, no safe words. Now available at https://www.dailywire.com/show/friendly-fire Get your Ben Shapiro merch here: https://bit.ly/3TAu2cw - - - Socials: Follow on Twitter: https://bit.ly/3cXUn53  Follow on Instagram: https://bit.ly/3QtuibJ  Follow on Facebook: https://bit.ly/3TTirqd  Subscribe on YouTube: https://bit.ly/3RPyBiB - - - Privacy Policy: https://www.dailywire.com/privacy Learn more about your ad choices. Visit podcastchoices.com/adchoices

The House is expected to force the release of the Epstein files, new details come to light about the suspect in the first attempted assassination of Donald Trump, and the U.S. and Venezuela signal a willingness to talk as a massive warship floats into the Caribbean. Get the facts first with Morning Wire. Hello Fresh: Go to https://HelloFresh.com/MORNINGWIRE10FM now to get 10 free meals + a free breakfast for life! Lumen: Go to https://lumen.me/WIRE to get an additional 15% off your Lumen. - - - Wake up with new Morning Wire merch: https://bit.ly/4lIubt3 - - - Privacy Policy: https://www.dailywire.com/privacy Learn more about your ad choices. Visit podcastchoices.com/adchoices

President Trump finally slams Rep. Majorie Taylor Greene after the Congresswoman's anti-Trump freelancing; the Trump administration promises affordability, but how can they achieve it?; and Michelle Obama still thinks America is awful. Click here to join the member-exclusive portion of my show: https://bit.ly/3WDjgHE Ep.2319 - - - Facts Don't Care About Your Feelings - - - DailyWire+: Join us now during our exclusive Deal of the Decade. Get everything for $7 a month. Not as fans. As fighters. Go to http://www.dailywire.com/subscribe to join now. Finally, Friendly Fire is here! No moderator, no safe words. Now available at https://www.dailywire.com/show/friendly-fire Get your Ben Shapiro merch here: https://bit.ly/3TAu2cw - - - Today's Sponsors: Perplexity - Ask anything at https://pplx.ai/benshapiro and try out their new AI-powered web browser Comet at https://comet.perplexity.ai/. PureTalk - Switch to PureTalk and start saving today! Visit https://PureTalk.com/SHAPIRO Policygenius - Head to https://policygenius.com/SHAPIRO to get your free life insurance quotes and see how much you could save. Lean (Brickhouse Nutrition) - Visit https://brickhousesale.com to save 30% on Black Friday deals. Lumen - Head to https://lumen.me/SHAPIRO to get an additional 15% off your Lumen. Shopify - Sign up for your $1-per-month trial and start selling today at https://Shopify.com/shapiro ZipRecruiter - Try ZipRecruiter FOR FREE: https://ZipRecruiter.com/DAILYWIRE - - - Socials: Follow on Twitter: https://bit.ly/3cXUn53  Follow on Instagram: https://bit.ly/3QtuibJ  Follow on Facebook: https://bit.ly/3TTirqd  Subscribe on YouTube: https://bit.ly/3RPyBiB - - - Privacy Policy: https://www.dailywire.com/privacy Learn more about your ad choices. Visit podcastchoices.com/adchoices

The government shutdown continues…but is an end in sight? Plus, we ask why Americans keep ping-ponging between parties, and examine what comes next with the Trump tariffs. Click here to join the member-exclusive portion of my show: https://bit.ly/3WDjgHE Ep.2314 - - - Facts Don't Care About Your Feelings - - - DailyWire+: Join us now during our exclusive Deal of the Decade. Get everything for $7 a month. Not as fans. As fighters. Go to http://www.dailywire.com/subscribe to join now. Finally, Friendly Fire is here! No moderator, no safe words. Now available at https://www.dailywire.com/show/friendly-fire Get your Ben Shapiro merch here: https://bit.ly/3TAu2cw - - - Today's Sponsors: PureTalk - Switch to PureTalk and start saving today! Visit https://PureTalk.com/SHAPIRO Equip Foods - Equip's Prime Bar is a real food protein bar with nothing to hide: just 11 ingredients and 20g of clean protein - made from ingredients you can pronounce like collagen, beef tallow, colostrum, cocoa butter - and sweetened naturally with just date and honey. Ben Shapiro listeners will get 25% off one-time purchases, or 40% off first subscription orders for a limited time by heading to https://equipfoods.com/benshapiro and using code BENSHAPIRO at checkout. Lumen - Head to https://lumen.me/SHAPIRO to get an additional 10% off your Lumen. Legacybox - Head to https://Legacybox.com/SHAPIRO today to preserve your family's history. Also visit https://get.dailywire.com/legacybox/ to submit a Veteran's story from you or your family for a chance to win a Legacybox and feature their legacy right here on our show. Tecovas - Right now get 10% off at https://tecovas.com/shapiro when you sign up for email and texts. - - - Socials: Follow on Twitter: https://bit.ly/3cXUn53  Follow on Instagram: https://bit.ly/3QtuibJ  Follow on Facebook: https://bit.ly/3TTirqd  Subscribe on YouTube: https://bit.ly/3RPyBiB - - - Privacy Policy: https://www.dailywire.com/privacy Learn more about your ad choices. Visit podcastchoices.com/adchoices

It's election day in New York City – so will New Yorkers commit political suicide? Plus, elections in New Jersey and Virginia could decide the future of the Democratic Party, and Nick Fuentes touts his victory over JD Vance. Click here to join the member-exclusive portion of my show: https://bit.ly/3WDjgHE Ep.2310 - - - Facts Don't Care About Your Feelings - - - DailyWire+: Join us now during our exclusive Deal of the Decade. Get everything for $7 a month. Not as fans. As fighters. Go to http://www.DailyWire.com/Subscribe to join now. Finally, Friendly Fire is here! No moderator, no safe words. Now available at https://www.dailywire.com/show/friendly-fire Get your Ben Shapiro merch here: https://bit.ly/3TAu2cw - - - Today's Sponsors: Policygenius - Head to https://policygenius.com/SHAPIRO to get your free life insurance quotes and see how much you could save. Shopify - Sign up for your $1-per-month trial and start selling today at https://Shopify.com/shapiro PreBorn! - Donate today and help save babies from abortion at https://preborn.com/BEN or dial #250 keyword 'BABY' NetSuite - Download the free business guide, Demystifying AI, at https://NetSuite.com/SHAPIRO Quo - Get 20% off of your first 6 months at Quo.com/BEN Lumen - Go to https://lumen.me/SHAPIRO to get an additional 10% off your Lumen. Kalshi - Visit https://kalshi.com today! - - - Socials: Follow on Twitter: https://bit.ly/3cXUn53  Follow on Instagram: https://bit.ly/3QtuibJ  Follow on Facebook: https://bit.ly/3TTirqd  Subscribe on YouTube: https://bit.ly/3RPyBiB - - - Privacy Policy: https://www.dailywire.com/privacy Learn more about your ad choices. Visit megaphone.fm/adchoices