Podcasts about Lumen

Welcome back for a quick-hitter from Zak and Brad, just ahead of the Sounder's rescheduled home match against Real Salt Lake. The guys preview that one, go through the limited list of players available and try and predict how the team will line up at Lumen. Some major retirement announcements to discuss as well, including Steve's old Akron friend and MLS star Darlington Nagbe. For fans attending the October 11th match, head over to Olympic Hall for a live podcast experience with both Brad Evans and Steve Zakuani!

What happens when you put a mic in front of HR leaders and ask them for their unfiltered takes on AI?In this episode, Daniel and Stephen recap their trip to HR Tech — where they recorded 12 quick-hit “AI Confessions” from folks they met on the conference room floor. From agentic workflows and custom GPT chaos to the real blockers slowing down AI adoption, this one's packed with candid insights from the front lines.You'll hear what HR leaders from companies like Lumen, Articulate, and Airbnb.---- Sponsor Links:

Send us a textThe biological roots of sleep are tied to mitochondrial metabolism.Episode Summary: Dr. Gero Miesenböck discusses the evolutionary and metabolic basis of sleep, exploring how mitochondrial energy production in neurons, particularly in fruit flies, drives the need for sleep to manage harmful byproducts like reactive oxygen species and lipid peroxides. They discuss how sleep-inducing neurons sense these byproducts, the role of mitochondrial dynamics, and the broader implications for why all animals, from jellyfish to humans, require sleep. The conversation also touches on how body size and metabolism influence sleep needs across species.About the guest: Gero Miesenböck, MD is a professor of physiology at the University of Oxford, renowned for his pioneering work in optogenetics and his research on the neurobiology of sleep using fruit flies and mice.Discussion Points:Sleep is universal across animals, even in jellyfish without centralized brains, suggesting a fundamental metabolic purpose tied to mitochondrial energy production.Mitochondria produce energy efficiently using oxygen but generate reactive oxygen species that can damage cells through lipid peroxidation, necessitating sleep to repair this damage.Sleep-inducing neurons in fruit flies contain sensors that track lipid peroxidation products, acting like a digital memory to signal when sleep is needed.Smaller animals with faster metabolisms, like mice, require more sleep and have shorter lifespans due to higher oxygen consumption and oxidative stress.Mitochondrial diseases in humans often cause intense tiredness, likely due to increased electron leaks in the mitochondrial energy production process.The evolutionary origin of sleep likely stems from the oxygen revolution 2.5 billion years ago, enabling complex life but requiring mechanisms like sleep to manage metabolic side effects.Caloric restriction reduces sleep need by lowering the production of harmful metabolic byproducts, supporting the link between metabolism and sleep.Reference paper:Study: Mitochondrial origins of the pressure to sleepRelated content:M&M 12: Organisms, Cities, Companies & the Science of Scale | Geoffrey West*Not medical advice.Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts

In this episode, we sit down with Nadia Ali, a health coach and digital nomad, to explore her transformative journey from battling disordered eating to embracing biohacking and metabolic flexibility. Nadia shares her insights on maintaining health while traveling the world, the impact of Lumen on her fitness journey, and the importance of trusting the process. Tune in for an inspiring conversation filled with practical tips and personal stories that highlight the power of resilience and self-discovery.

Send us a textThe surprising link between oral bacteria and heart disease.Episode Summary: Dr. Pekka Karhunen explains the connection between oral bacteria, cholesterol, and cardiovascular disease, discussing how oxidized LDL cholesterol triggers inflammation in arteries, how bacteria from the mouth can infiltrate arterial plaques to form biofilms, and the implications for heart disease prevention through lifestyle changes like better oral hygiene.About the guest: Pekka Karhunen, MD, PhD is a medical doctor and forensic pathologist with decades of experience, specializing in cardiovascular diseases. He has created a unique biobank of coronary arteries from over 10,000 autopsies conducted in Finland. His research focuses on the role of bacteria in atherosclerosis, particularly through studying coronary artery plaques.Discussion Points:Cholesterol is essential for life, but oxidized low-density lipoprotein (LDL) cholesterol is seen as a foreign substance by the immune system, leading to chronic inflammation in coronary arteries.Macrophages ingest oxidized LDL, turning into dysfunctional foam cells that contribute to plaque buildup, known as atheromas, in arteries.Plaque rupture, potentially caused by increased pressure from cholesterol accumulation or hemorrhage within the plaque, can trigger heart attacks.Bacteria, especially from the mouth, can enter arterial plaques via bacteremia (e.g., from dental procedures) and form biofilms, evading immune detection.Biofilms in plaques, made of extracellular matrix like polysaccharides, protect bacteria and may contribute to plaque instability or calcification over time.Poor oral hygiene is linked to higher cardiovascular disease risk, as bacteria from dental infections can enter plaques, suggesting dental care as a preventive measure.Karhunen's research found oral bacteria, like Viridans streptococci, in coronary plaques, with unpublished data also detecting gut and skin bacteria, indicating diverse bacterial involvement.Related content:M&M 247: Cholesterol: Immune Benefits, Heart Health, Statins & Research Malpractice | Uffe Ravnskov*Not medical advice.Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts

Join us as we dive into Maureen's inspiring journey with Lumen. From battling weight gain and early perimenopause to discovering a sustainable lifestyle change, Maureen shares her challenges, triumphs, and the surprising lessons learned along the way. Discover how she embraced real food, overcame self-doubt, and found a supportive community that helped her lose 50 pounds and transform her life. Tune in for an empowering conversation about resilience, self-care, and the power of trusting the process.

In this episode of the Open Hardware Manufacturing Podcast, Stephen and Lucy talk about what it's really like to advertise in the open hardware world. From running social media ads to trying out print campaigns, they share what worked, what didn't, and what they learned along the way.They touch on things like figuring out who your audience actually is, why selling machines like the Lumen pick and place takes patience, and how good messaging and customer feedback make all the difference. Instead of chasing quick wins, they dig into how brand awareness can matter more than immediate sales.You'll hear them cover:Marketing vs. advertising and why the difference mattersHow to understand what customers need (and how to show you can solve it)The tricky part of measuring ad resultsSocial media, search ads, sponsorships, and where they fitExamples of ad campaigns that hit the mark, and ones that missed---Join the conversation and share your thoughts at hardware.cafe.Do you have any questions, comments, or topic suggestions? Email us at podcast@opulo.io. We'd love to hear from you!To learn more about what we do, visit Opulo.io.To see everything else we do, including social media, visit Opulo.start.page.O.H.M. Podcast Merch is now here!Intro song:Complicate Ya - Otis McDonald (Creative Commons Attribution License) Hosted on Acast. See acast.com/privacy for more information.

Send us a textHow nutrition and medications impact mitochondrial health.Wide release date: October 1, 2025.Episode Summary: Dr. Chris Masterjohn talks about the intricate relationships between nutrition, prescription drugs, and mitochondrial health, discussing how molecules like acetaminophen and SSRIs affect the body beyond their intended purposes, particularly impacting inflammation and energy metabolism. The discussion gets into the broader implications of serotonin outside the brain, the side effects of commonly used medications, and the importance of personalized nutritional strategies to optimize mitochondrial function.About the guest: Chris Masterjohn, PhD holds a doctorate in nutritional sciences and is a co-founder of Mitome, a company focused on mitochondrial testing to optimize cellular energy production.Discussion Points:Acetaminophen & Inflammation: Acetaminophen (Tylenol) may contribute to chronic low-grade inflammation by blocking both the initiation and resolution of inflammation, potentially linked to health issues like autism when used during pregnancy.Serotonin's Role Beyond the Brain: Approximately 95% of serotonin is found in the gut, regulating motility, with SSRIs causing side effects like nausea due to increased extracellular serotonin.SSRIs & Mitochondrial Function: SSRIs disrupt serotonin uptake into cells, reducing mitochondrial melatonin production, which impairs the body's ability to handle hypoxic stress and produce ATP efficiently.Statins & Mitochondrial Impact: Statins, used to lower cholesterol, inhibit the mevalonate pathway, affecting not just cholesterol but also CoQ10 and vitamin K2, crucial for mitochondrial function, potentially leading to side effects like myopathy.Mitochondrial Testing with Mitome: Masterjohn's company, Mitome, uses cheek swab tests to measure mitochondrial respiratory chain activity, providing personalized dietary and lifestyle recommendations to optimize cellular energy production.Nutrition & Mental Health: Masterjohn shares his personal experience of severe mental health issues on a vegan diet, which improved dramatically with a nutrient-dense diet rich in organ meats, highlighting individual nutritional needs.Energy Metabolism's Universal Role: Mitochondrial ATP production governs everything from daily energy levels to long-term health, with personalized testing helping identify and address specific bottlenecks.*Not medical advice.Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts

At The Media Leader's Future of Media Manchester event last week, effectiveness expert Peter Field and Newsworks insights director Heather Dansie presented new research that shows investing in high-attention media channels — TV, cinema, radio, news brands and magazine brands — is more profitable than investing in low-attention ones.And yet, over the past decade, adspend has flowed to social media and pure-play internet, and away from those channels.What accounts for this? And what would happen if marketers heeded effectiveness research that repeatedly indicates a severe over-investment in ineffective, short-termist digital media inventory?During the conference, Field and Dansie sat down with Lumen CEO and report co-author Mike Follett for a special live edition of the podcast with Jack Benjamin.The trio of industry-leading researchers unpacked the findings and criticised media planners for failing to responsibly invest their clients' money in media placements with long-term benefits."My suggestion to media planners is: do your fucking job," said Follett. "Don't take the easy thing. Actually think: where am I going to get the best result for my clients?"Highlights:1:12: Topline takeaways from the research5:38: Methodology and why smaller brands must embrace advertising beyond performance12:25: Why has ad investment shifted away from high-attention media? CFOs driving the agenda and lazy media planners19:05: Are all news brands equal?24:25: Why aren't evidence-based arguments sinking in?Related articles:High-attention media is more profitable, finds Peter Field, Lumen and NewsworksDigital adspend to grow by double digits in 2025 and 2026One-third of indie publishers could shut down by next year as AI search hits trafficAre advertisers ‘swimming in a sea of garbage'?---Thanks to our production partners Trisonic for editing this episode.--> Discover how Trisonic can elevate your brand and expand your business by connecting with your ideal audienceVisit The Media Leader for the most authoritative news analysis and comment on what's happening in commercial media. LinkedIn: The Media LeaderYouTube: The Media Leader

Joaquin Cordero is the Founder and President of Lumen, a communications company that provides creative and advertising services including media commercialization, 360-degree agency work, BTL, print, and point-of-purchase services. He founded Lumen in 2009 in Guatemala, expanding it into El Salvador and Honduras and serving both local and global brands. Joaquin has also founded over eleven companies, and serves in leadership roles in the Entrepreneurs' Organization, including Global Board Director and EO Global Chair-Elect. In this episode… Stepping away from the day to day demands of your own company can feel risky when growth and stability are on the line. Yet some of the most successful entrepreneurs insist that leading beyond their business creates new energy and ideas. How can taking on outside leadership roles actually spark innovation and strengthen resilience? According to Joaquin Cordero, a global entrepreneurial leader, dedicating time to serve in volunteer leadership opens doors to fresh perspectives and powerful relationships. He highlights how working with peers who run their own companies forces you to lead by influence and build trust instead of relying on authority. This approach has helped him foster a stronger company culture and inspire long term loyalty among his team. Joaquin's experiences prove that growth often happens when you challenge yourself beyond your own organization. In this episode of the Smart Business Revolution Podcast, John Corcoran speaks with Joaquin Cordero, Founder and President of Lumen, to talk about why stepping outside your business sparks innovation and resilience. They explore how serving in global leadership roles fuels personal and professional growth and how trust and collaboration transform company culture. Joaquin also shares lessons from navigating unexpected challenges and building long-term client relationships.

Send us a textGenetic & environmental factors that affect brain health, including why people age faster in outer space. (Note: technical difficulties affected the audio quality of this recording somewhat)Episode Summary: Dr. Jacob Raber explains how apolipoproteins, particularly ApoE, influence brain health and disease risk; their role in cholesterol metabolism, Alzheimer's disease, and responses to environmental stressors like radiation and viral infections; interplay between genetics, diet, and lifestyle factors, highlighting how these affect cognitive function and resilience to stress; research into space radiation, the gut-brain axis, and potential interventions for neurodegenerative diseases.About the guest: Jacob Raber, PhD, is a neuroscientist at Oregon Health & Science University (OHSU) in Portland, where he leads a lab studying genetic and environmental influences on brain health, particularly using mouse models with human genes.Discussion Points:Apolipoproteins (ApoE2, E3, E4) are proteins involved in cholesterol and lipid metabolism in the brain, with ApoE4 increasing risks for Alzheimer's and cardiovascular disease.ApoE4 carriers may face higher risks for cognitive decline but could have advantages in specific contexts, like fertility or certain infections.Environmental stressors, such as space radiation and viral infections like West Nile, can exacerbate oxidative stress, impacting brain health.The gut microbiome influences brain function indirectly via the gut-liver-brain axis, with ongoing studies exploring its role in Alzheimer's and traumatic brain injury.Lifestyle factors like diet, exercise, and sleep are critical for brain health, potentially mitigating genetic risks like ApoE4.Statins, commonly used for cholesterol management, may impair learning in healthy animals, suggesting context-dependent effects.Research into space radiation reveals potential therapeutic applications, such as using heavy ion radiation for cancer treatment.Genetic variations, including ethnicity and sex, influence ApoE-related disease risks, with women and certain populations showing higher Alzheimer's susceptibility.Chronic low-level stressors, like air pollution, may pose greater risks to brain health than acute exposures due to insufficient activation of protective mechanisms.Related content:M&M 165: PUFAs in Brain Health & Disease, Dietary Fats, Brain Lipids, Nutrition | Richard Bazinet*Not medical adviceSupport the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts

In this episode,  we sit down with Amanda Smyth, a vibrant Londoner who splits her time between the UK and Turkey.  Amanda shares her inspiring journey from overtraining and yo-yo dieting to discovering a balanced lifestyle with the help of Lumen.  Learn how Amanda transformed her approach to health, embraced metabolic flexibility, and found joy in fitness.  Whether you're looking to improve your metabolism or simply seeking motivation to live life to the fullest,  Amanda's story offers valuable insights and encouragement.  Tune in to explore the power of patience, community, and self-discovery on the path to wellness.

Today, Fiona chats to Lucy Lumen - photographer, YouTuber, content creator, and creative business mentor who has built a thriving online business alongside her husband.In this episode, you'll learn:• How Lucy went from working in hospitality for 10+ years to accidentally building a photography and videography business• Why she decided to pivot away from client work and go all-in on YouTube content creation• Her process for creating 8 YouTube videos per month across two channels while managing Substack and social media• How sponsorships (not ad revenue) make YouTube financially sustainable as a full-time career• The reality of working with your spouse and managing business partnerships• Why developing a distinct personal style is more important than technical perfection in the age of AILucy shares honest insights about the realities of content creation, building a creative business, and how to turn your passion into sustainable income while maintaining work-life balance.A massive thank you to our sponsor and our fave AI tool, Poppy AI. Use FIONA at checkout for a discount Connect with My Daily Business:Instagram: @mydailybusiness_TikTok: @mydailybusinessEmail: hello@mydailybusiness.comWebsite: mydailybusiness.comConnect with Lucy LumenInstagram: @lucy_lumenSubtack: Love LucyYouTube: The Lucy Lumen ShowYouTube: Lucy LumenWebsite: lucylumen.com Resources mentioned:Join our AI Chat Group for small business ownersGroup CoachingMy Daily Business courses - mydailybusiness.com/courses ⭐️ GET MORE TIME BACK with our fave AI tool that has saved us HOURS. Use Poppy AI and code FIONA for a discount ⭐️ Need some inspiration and tips today? Check out our new book, Business to Brand: Moving from transaction to transformation now. Get started on a more successful and sustainable small business with our range of free tools at mydailybusiness.com/freestuff Want to know more about AI and how to harness it for your small businesS? Join our new monthly AI chat for small business owners. You can join anytime at www.mydailybusiness.com/AIchat Try out my fave AI tool, Poppy AI here and use discount code FIONA. Ever wanted to write your own book and build your brand authority or start your own podcast to connect with and grow your audience? Check out our How to Start a Podcast Course or How to Get Your Book Published Course at our courses page. Connect and get in touch with My Daily Business via our shop, freebies, award-winning books, Instagram and Tik Tok.

In this episode, Mardi Winder welcomes J. Lumen, a transformational trainer, certified master life coach, and bestselling author, for an honest and heartfelt conversation about moving forward when life throws you off course. J. opens up about her own story, which started with all the pieces in place. She had a long-term relationship, a “good” job, and a life that, from the outside, seemed just fine. But beneath the surface, things were far from okay. She describes feeling drained and trapped, responsible for everything, and convincing herself she had to tough it out until life magically improved.Things took an unexpected and frightening turn after she ended her relationship, when her ex-boyfriend showed up out of the blue and held her hostage in her home. She shares how the situation quickly escalated to a traumatic, life-altering ordeal. J. talks candidly about how there were no classic warning signs, sharing her experience as a cautionary tale.Rather than staying stuck in fear or regret, J. explains how she used the experience to hit reset on her life. She and Mardi discuss finding happiness by reconnecting with your core values, remembering what used to bring you joy, and realizing you've already made it through challenges before. They make it clear that no one has to have everything figured out before taking the first step. Instead, J. encourages exploring new interests, giving yourself space to mess up and learn, and trusting that confidence grows from action and curiosity, not perfection.Throughout the conversation, J. brings warmth and humor, reminding listeners that big life changes don't have to wait for a crisis. She also offers a free self-assessment tool to help people get started, showing that small steps and self-reflection can make a huge difference. This episode is full of supportive, practical advice for anyone feeling stuck or ready for a new chapter.About the Guest:J. Lumen is a Transformation Trainer, an International Speaker, Certified Master Life Coach and an International best-selling contributing author. J. knows first-hand how it feels to be silently dissatisfied with life. For her, this was feeling trapped in a relationship that was emotionally over and at a toxic job she hated but not seeing a way out or even what she wanted. Eventually breaking free from the relationship, she convinced herself of all the reasons to keep the job and figure out what she wanted. But two months later, an unexpected knock at her door changed her life drastically as the night ended with an arrest for attempted murder. Of her. Using her own transformation, she's on a mission to empower others to stop waiting for a life-altering event of their own and start living a life they'd never imagine possible, full of authentic joy and one they don't regret.For J.'s gift: https://resumeyourlife.com/To connect with J: Website: https://theunknownbucketlist.com/ LinkedIn: www.linkedin.com/in/J.lumen8 Instagram: https://www.instagram.com/theunknownbucketlist/About the Host: Mardi Winder is an ICF and BCC Executive and Leadership Coach, Certified Divorce Transition Coach, Certified Divorce Specialist (CDS®) and a Credentialed Distinguished Mediator in Texas. She has worked with women in executive, entrepreneur, and leadership roles, navigating personal, life, and professional transitions. She is the founder of Positive Communication Systems, LLC, and host of Real Divorce Talks, a quarterly series designed to provide education and inspiration to...

Send us a textHow maternal obesity epigenetically reprograms liver metabolism in offspring, predisposing them to metabolic disease.Episode Summary: Dr. Elvira Mass talks about macrophages, specialized immune cells that vary by tissue and play crucial roles beyond fighting infections, such as supporting organ function; Kupffer cells (liver macrophages) and how maternal obesity during pregnancy reprograms these cells in offspring, leading to fatty liver disease, fibrosis, and even cancer later in life, based on mouse studies showing epigenetic and metabolic shifts like increased glycolysis, with insights into developmental windows, nutritional mismatches, and broader implications for human health.About the guest: Elvira Mass, PhD, is a Professor of Developmental Immunology at the University of Bonn in Germany, where her lab focuses on the development and function of macrophages in various tissues.Discussion Points:Macrophages are diverse, tissue-specific cells that develop from embryonic precursors, performing unique tasks like providing growth factors in organs.Kupffer cells in the liver monitor blood from the gut and are exposed to maternal nutrients during fetal development.Maternal obesity (induced in mice via high-fat diets) programs offspring Kupffer cells epigenetically, leading to fatty liver in newborns and progression to diseases like cancer, even on normal diets.A "nutritional mismatch" between in utero high-fat exposure and postnatal normal diets worsens liver issues, as cells are "prepared" for excess high-fat intake but face scarcity.Key mechanism: Reprogrammed Kupffer cells overproduce apolipoproteins, driving excess lipid uptake in liver cells (hepatocytes), linked to transcription factor HIF-1α and a shift to inefficient glycolysis.Offspring from obese mothers show sex differences (males affected earlier) and persistent changes.Human parallels: Rising childhood fatty liver (once rare and tied to alcoholism) correlates with maternal obesity; studies like Dutch Hunger Winter show early gestational disruptions cause lifelong issues.Broader factors: Microbiome changes, specific fatty acids, and environmental toxins like microplastics may also reprogram macrophages; diets in studies vary beyond fat content, affecting results.Advice: Maintain consistent healthy habits pre- and during pregnancy; avoid sudden diet shifts, as developmental windows are critical for long-lived cells like Kupffer cells.Reference Paper:Study: Kupffer cell programming bySupport the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts

In this episode, we dive into the inspiring journey of Henry Goode, who transformed his life with the help of Lumen. From overcoming physical setbacks to discovering the power of nutrition and community, Henry shares his personal story of resilience and determination. Join us as we explore the challenges and triumphs of his path to a healthier lifestyle, and learn how passion and purpose can drive lasting change.

The Seattle Seahawks had another dominant defensive performance this week against the Pittsburgh Steelers. We're celebrating a 31-17 win and some of the standout defensive performances. We discuss the emergence of Josh Jobe, Byron Murphy's impact, and how Mike Macdonald's coaching is shaping a resilient, and seemingly plug-and-play, defense. The impressive road win streak continues, but can they find a way to bring that success into Lumen? On offense, we highlight JSN's big play, the impact of Cooper Kupp, Ken Walker's explosive day, and the adjustments made by Klint Kubiak to get the play-action game rolling. Stick around for “Do Better” and “Better at Life” as we call out NFL conspiracies, production team blunders, and pay tribute to podcasting pioneer Todd Cochrane. Join our Sea Hawkers Podcast Pickem League - free prizes for weekly winners. Support the show Get in the Flock! Visit GetInTheFlock.com Or visit our website for other ways to support the show Subscribe via: Apple Podcasts | Spotify | Google Podcasts | YouTube | TuneIn | RSS Follow us on: Facebook | Twitter Listen on our free app for Android, iOS, Kindle or Windows Phone/PC Call or text: 253-235-9041 Find Sea Hawkers clubs around the world at SeaHawkers.org Music from the show by The 12 Train, download each track at ReverbNation    

Ellen Lampert-Greaux is the creative director for Live Design and LDI, an annual conference and trade show for entertainment design and technology professionals. She was on the five-person team that founded LDI in 1988, and has produced the conference and worked on special events for the show since its debut, working on all aspects from programming and promotion to operations, registration, and the attendee experience. She has also produced additional events for the Live Design/LDI franchise such as their Master Classes series for lighting, projection, audio, scenic design; the Envision Symposium; Backstage Las Vegas; and XLIVExLDI. She is also a triple award-winning writer - editor for Live Design (FOLIO: EDDY Award in 2021, 2022, and 2023) who specializes in entertainment design and technology, writing regularly for livedesignonline.com, as well as a freelance writer on technology and architectural lighting. She is also a co-host ( a Lumen sister) on the Light Talk podcast.She attended NYU where she was an English major, and Temple University for a BFA in television/film production. She earned her MFA in arts administration from Brooklyn College and was the publicity director of the Brooklyn Academy of Music (1979-1986). She is a theatrical press agent and a member of ATPAM/IATSE, as well co-founder in 1996 and co-director of the St. Barth Film Festival in the French West Indies, having run a similar festival in Avignon, France (1984-1993). She speaks fluent French and translates articles for magazines from French to English. This conversation explores the evolution and impact of LDI since its inception in 1988, highlighting the commitment of Light Switch to enhance experiences through design. The discussion covers various training opportunities, innovative events, and the importance of inclusivity and networking within the entertainment industry. The future of LDI is also addressed, emphasizing its role in fostering mentorship and professional growth.This Episode is brought to you by Lightswitch

Curare con gli ultrasuoni. Non è un novità assoluta bensì qualcosa che già si fa, ma non se il bersaglio da colpire si trova nel cervello, protetto da una barriera quale la scatola cranica. Una barriera che non fa passare in modo controllabile nemmeno le vibrazioni.Superare questa barriera è l’obiettivo di LUMEN, progetto cui è stato assegnato un ERC Grant da circa 1,5 M€ e che mira ad aggirare il problema trasformando la scatola cranica stessa in una sorta di campana la quale, fatta vibrare in modo opportuno, permetterebbe di concentrare l’energia acustica su un bersaglio preciso: un nuovo approccio alla cosiddetta "stimolazione cerebrale transcranica" che potenzialmente potrebbe dare benefici a milioni di persone che soffrono di disturbi quali il Parkinson o di dolore di origine neurologica.Ospite Emanuele Riva, ricercatore del Dip Mecc del Polimi.

Curare con gli ultrasuoni. Non è un novità assoluta bensì qualcosa che già si fa, ma non se il bersaglio da colpire si trova nel cervello, protetto da una barriera quale la scatola cranica. Una barriera che non fa passare in modo controllabile nemmeno le vibrazioni.Superare questa barriera è l'obiettivo di LUMEN, progetto cui è stato assegnato un ERC Grant da circa 1,5 M€ e che mira ad aggirare il problema trasformando la scatola cranica stessa in una sorta di campana la quale, fatta vibrare in modo opportuno, permetterebbe di concentrare l'energia acustica su un bersaglio preciso: un nuovo approccio alla cosiddetta "stimolazione cerebrale transcranica" che potenzialmente potrebbe dare benefici a milioni di persone che soffrono di disturbi quali il Parkinson o di dolore di origine neurologica.Ospite Emanuele Riva, ricercatore del Dip Mecc del Polimi.

Send us a textAging, tissue repair, and the longevity benefits of psilocin.Episode Summary: Dr. Louise Hecker discusses her research on tissue repair and regeneration, explaining how fibroblasts drive wound healing by forming scar tissue but fail to resolve properly with age, leading to fibrotic diseases like pulmonary fibrosis and liver cirrhosis; they discuss aging hallmarks such as oxidative stress and telomere shortening, and highlight Hecker's study showing psilocybin's active metabolite, psilocin, extends cellular lifespan in lab cultures by reducing oxidants and preserving telomeres, while monthly doses in aged mice improved appearance and survival rates.About the guest: Louise Hecker, PhD is an Associate Professor of Medicine at Baylor College of Medicine, specializing in repair and regeneration processes, particularly in aging and fibrotic diseases.Discussion Points:Fibroblasts are dormant cells that activate during injury to pull wounds closed and form scars, then de-differentiate or die; aging impairs this, causing persistent scarring and disease.Aging reduces the body's regenerative capacity; different organs vary in repair efficiency, with skin healing better than heart tissue.Oxidative stress, like "rust" in the body, accumulates with age due to imbalanced reactive oxygen species production and antioxidant defenses, contributing to cellular damage.Telomeres act as protective DNA caps that shorten with cell divisions, serving as a hallmark of biological aging; sirtuins are master regulators influencing aging processes.Hecker's in vitro study showed psilocin dose-dependently extended fibroblast lifespan by 29-50%, lowering oxidative stress below young cell levels and preserving telomeres.In aged mice (equivalent to 60-65 human years), monthly high-dose psilocybin (15 mg/kg) led to healthier appearance, regrown fur, and 80% survival when controls reached 50% mortality after 10 months.Psilocybin's effects may stem from serotonin receptors expressed in many cell types beyond the brain, suggesting broader anti-aging potential; future work explores mechanisms, optimal dosing, and applications for age-related diseases.Fungi like magic mushrooms represent an under-explored "kingdom" for medicine, with psilocybin's durable effects hinting at systemic impacts on aging.Reference Paper:Study: Psilocybin treatment extends cellular lifespan and improves survival of aged miceRelated content:Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts

Send us a textThe effects of protein restriction on metabolism, liver hormones, brain, and behavior.Episode Summary: Dr. Christopher Morrison talks about how animals sense and prioritize nutrients like protein, discussing defense mechanisms for essentials such as oxygen, water, sodium, and energy; the brain's role in detecting protein deprivation via signals like FGF21; trade-offs between growth, reproduction, and longevity under protein restriction; and reconciling high-protein diets for satiety and muscle maintenance with low-protein benefits for metabolic health and lifespan extension.About the guest: Christopher Morrison, PhD is a professor and researcher at the Pennington Biomedical Research Center in Baton Rouge, Louisiana, where he has worked for over 22 years focusing on nutrition, metabolism, and chronic diseases like obesity and diabetes.Discussion Points:The body prioritizes nutrients hierarchically: oxygen and water first, then sodium, energy, and protein, with weaker defenses for carbs or fats.Animals develop specific appetites for deprived nutrients, like salt or protein, often through post-ingestive learning rather than just taste.Protein restriction (e.g., 5% vs. 20% in diets) increases food intake and energy expenditure in mice to maintain protein levels, even at the cost of extra calories.FGF21, a liver hormone, signals protein deprivation to the brain (via NTS region), driving protein-seeking behavior and metabolic changes; it's essential for low-protein responses.Protein restriction extends lifespan in lab animals by suppressing growth signals like IGF-1 and mTOR, but may impair immunity or wound healing in real-world conditions.High protein aids satiety, weight loss, and muscle building, but overconsumption may shorten lifespan; optimal intake depends on age, activity, and goals (e.g., not for pregnant or elderly).No one-size-fits-all for protein: mild restriction may benefit middle-aged sedentary people for health, while athletes need more; balance avoids excesses.Related content:M&M 106: Diet, Macronutrients, Micronutrients, Taste, Whole vs. Processed Food, Obesity & Weight Loss, Comparative Biology of Feeding Behavior | Stephen Simpson & David Raubenheimer*Not medical advice.Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts

“We are now branding ourselves as the trusted infrastructure supporter of AI,” says Scott Eaton, Sr. Director, Partner Management at Lumen, in a conversation with Doug Green, Publisher of Technology Reseller News, during ScanSource Partner First. Eaton explained that Lumen, built on the combined legacies of CenturyLink, Level 3, Savvis, and Global Crossing, has transitioned from its telco roots into a technology company focused on powering AI with bandwidth and infrastructure services. Through solutions like wave services, DIA services, data centers, and rapid routes, Lumen provides the backbone for enterprises facing high-intensity data demands. At Partner First, the company highlighted its long-standing partnership with Intelisys, now part of ScanSource, where it has operated for over 20 years in an agency model of recurring commissions. Eaton emphasized that Lumen enables resellers to expand beyond equipment sales and deliver complete customer solutions—moving from “mailbox money” to strategic recurring revenue streams. To simplify adoption, Lumen and ScanSource provide partners with API-driven quoting and ordering tools, training, and field engineering support. This ensures that partners can more easily engage in infrastructure sales, which Eaton described as essential for AI-era growth: “From an AI perspective, it's all about the data… and the high bandwidth requirements to support it.” Eaton noted that partners at the show are eager to learn how to get started, educate themselves, and go deeper with customers. He encouraged resellers to leverage both Lumen's resources and ScanSource's support teams to accelerate success. For more information, visit lumen.com.

The divisional rival 49ers rolled into Lumen far from full strength and yet more than earned the victory they walked away with after a hard-fought game. There are plenty of excuses, but the bottom line appears Seattle is still not on San Francisco's level. Link to my YouTube Channel. Live on Wed and Sunday, 5PM PST...https://www.youtube.com/@TheHawksNest12thman?sub_confirmation=1 Use promo code NEST on Sleeper and get 100% match up to $100! https://Sleeper.com/promo/NEST. Terms and conditions apply. #Sleeper Link to my Patreon....https://www.patreon.com/thehawksnest Twitter...@SeahawksNester Twitch...@TheSeahawksNest

Send us a textSupport the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts

Hier gibt's mehr Infos zum Private-Equity-Angebot von Scalable Capital. Der Kalender zum Podcast? Jetzt kaufen. Sweeney & American Eagle provozieren erfolgreich. Lumen will mit Palantir KI-Firma sein. Goldman Sachs x T. Rowe Price & Citigroup x BlackRock. Sanofi leidet. Porsche & Sartorius fliegen aus DAX. Lululemon & Broadcom mit Zahlen. Covestro hat EU-Stress. Das Spielzeug von Mattel (WKN: 851704) hat jeder. Die Aktie fast niemand. Ein Fehler? „Carglass repariert, Carglass tauscht aus.“ In den ikonischen Jingle kann man an der Börse leider nicht investieren. Aber in den Carglass-Miteigentümer: Den BlackRock Private Equity Fund (WKN: A410GZ). Diesen Podcast vom 05.09.2025, 3:00 Uhr stellt dir die Podstars GmbH (Noah Leidinger) zur Verfügung.

Send us a textCellular clean up by immune cells and how early-life fructose exposure leads to neurodevelopmental problems.Episode Summary: Dr. Justin Perry talks about the body's constant cellular turnover—about 3 million cells die per second in adults (double in children and women)—handled by phagocytes like macrophages that engulf and digest debris to prevent diseases like lupus. They explore phagocytosis steps, macrophage adaptations in tissues like the brain (microglia), and how high fructose intake impairs microglial function in developing mice, leading to uncleared brain cells and anxiety-like behaviors, with implications for human neurodevelopmental disorders amid rising fructose consumption.About the guest: Justin Perry, PhD is an immunologist and clinical psychologist who leads a lab at Memorial Sloan Kettering Cancer Center focusing on how the body clears dead cells and debris to maintain homeostasis.Discussion Points:The body turns over 1-2% of its 30 trillion cells daily, mostly blood cells, but neurons in kids and endometrium in women turnover at ~2x this ratePhagocytosis involves "find me," "eat me," and digestion signals; failures can cause autoimmunity.Microglia are brain macrophages that uptake fructose via GLUT5 transporter.Early high fructose exposure (comparable to one soda daily) impairs the pruning of synapses and dead neurons.In mice, prenatal or postnatal fructose causes phagocytosis deficits in the prefrontal cortex, leading to heightened fear responses and poor fear extinction, mimicking anxiety disorders.Fructose correlates with rising neurodevelopmental issues like autism and anxiety; it's passed via breast milk, and liquid forms (e.g., sodas) overwhelm metabolic shields more than solid fruits.Macrophages may hold keys to diseases from atherosclerosis to cancer; deleting GLUT5 in microglia reverses fructose's effects, hinting at evolutionary roles in aging or low-oxygen states.Related content:M&M 215: Cancer Metabolism: Sugar, Fructose, Lipids & Fasting | Gary PattiArticle | Dietary Fructose & Metabolic Health: An Evolutionary PerspectiveReference Paper:Study | Early life high fructose impairs microglial phagocytosis and neurodevelopment*Not medical advice.Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts

In this episode of ACR Journals on Air, host Dr. Vicki Shanmugam speaks with Dr. Alain Sanchez-Rodriguez about a new study from the Lupus Midwest Network (LUMEN), published in Arthritis Care & Research. They explore how patients with systemic lupus erythematosus (SLE) experience delays and disparities in care, the types of physicians involved in diagnosis, and what the data reveals about access to specialized treatment. Dr. Sanchez-Rodriguez also shares his research journey and insights on improving equity in rheumatology. 

Send us a textThe potential link between acetaminophen (Tylenol) and autism, with a surprise phone call from RFK partway through.Episode Summary: Dr. William Parker talks about autism spectrum disorder (ASD), its rising prevalence since the 1980s, and the controversial hypothesis that acetaminophen exposure in susceptible infants and children triggers most cases via oxidative stress. They discuss ASD's clinical definition; historical misconceptions like the "refrigerator mother" theory; genetic susceptibilities; acetaminophen's metabolism, which produces toxic byproducts in underdeveloped livers, leading to brain effects.About the guest: William Parker, PhD spent nearly 30 years as a professor at Duke University researching underlying causes of chronic conditions, including discovering the immune function of the human appendix and pioneering studies on immune systems in wild animals.Discussion Points:Autism is a spectrum disorder with core symptoms like social deficits, repetitive behaviors, and aversion to new stimuli.Parker argues overwhelming evidence points to acetaminophen as the primary trigger in susceptible individuals, causing oxidative stress via toxic metabolite NAPQI.Acetaminophen, marketed as Tylenol or paracetamol, was not tested for neurodevelopmental effects in neonatal animals until 2014, despite widespread use since 1886; it's metabolized differently in babies, whose livers lack mature detox pathways.Susceptibility factors include low glutathione (an antioxidant), poor sulfation/glucuronidation metabolism, folate receptor autoantibodies, and events like immune reactions that prompt acetaminophen use during oxidative stress.Regressive autism, where children lose milestones after seeming normal, often follows acetaminophen given for fevers or illnesses, explaining parental vaccine suspicions (as shots coincide with drug use).Adult acetaminophen is generally safe but causes liver toxicity in overdoses or with alcohol; antidote is NAC to boost glutathione.Parker has suggested to policymakers that we should avoid acetaminophen during pregnancy, birth, and early childhood (under age 3-5); parents should plan ahead for fevers/pain without it, but seek medical help for unusual symptoms.*Not medical advice.Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts

-- On the Show: -- Democrat Catelin Drey defeats Republican Christopher Prosch in an Iowa Senate special election flipping a Trump district and ending the GOP supermajority -- Donald Trump deploys more than 2,200 National Guard troops from multiple states to collect trash in Washington DC as part of a beautification mission -- The White House pushes back as questions mount over Donald Trump's health after visible bruises, swelling, and cognitive slip-ups -- Trump makes false claims about crime, autism, prescription drugs, and restaurants while Robert F Kennedy Jr rants about radioactive shrimp during a chaotic cabinet meeting -- Cabinet officials and allies, including Tulsi Gabbard, Kristi Noem, Kelly Loeffler, and others, lavish praise on Donald Trump in an extraordinary display of flattery -- Support among young men who backed Trump in 2024 collapses as economic struggles, immigration raids, and broken promises sour his appeal -- California Governor Gavin Newsom publicly raises concerns about Trump's mental fitness -- Trump mocks Gavin Newsom's hand movements while Newsom fires back online -- Trump posts a series of late night Truth Social rants boasting about fundraising, crime, and attacking Seth Meyers -- Charlie Kirk tells Taylor Swift to reject feminism and submit to her fiancé, Travis Kelce, in a bizarre rant about their engagement -- On the Bonus Show: Trump signs an executive order against flag burning, Trump wants to change the Defense Department's name to the Department of War, US threatens to withhold funding from states over truck driver English proficiency rules, and much more...

Send us a textWide release date: August 25, 2025Episode Summary: Dr. Uffe Ravnskov talks about his decades-long career challenging the idea that high cholesterol causes heart disease, discussing LDL's protective role in the immune system by binding to bacteria, the harms and biases in statin research influenced by pharmaceutical companies, evidence that high cholesterol benefits the elderly and reduces infection/cancer risks, and how mental stress or infections elevate cholesterol as a response rather than a cause.About the guest: Uffe Ravnskov, MD, PhD is a physician and independent researcher who earned his MD from the University of Copenhagen in 1961 and a PhD in nephrology. He has worked in various clinics in Sweden since the 1960s, focusing his research on challenging the cholesterol hypothesis in heart disease. Now 91, he has published over 200 papers, authored books like "The Cholesterol Myths.”Discussion Points:LDL cholesterol helps the immune system by sticking to bacteria, clumping them for removal; low LDL increases infection risk.Animal studies show injecting LDL protects against lethal infections, while historical data links severe infections to worse atherosclerosis.Elderly people with high cholesterol live longer; low cholesterol raises mortality risk more than high levels.Familial hypercholesterolemia (FH) doesn't cause early death via cholesterol alone—co-inherited coagulation factors are the issue, and FH patients often have lower infection rates.Statins lower LDL but increase infection risk, cause muscle weakness/brain issues (often blamed on aging), and show no clear benefit in unbiased meta-analyses.Research biases include cherry-picking studies, exaggerating benefits via relative (not absolute) risk, and pharma funding suppressing critical views.Mental stress can raise cholesterol by 10-50% in 30 minutes, often misread as a heart disease cause rather than an effect.Saturated fat and high cholesterol aren't proven harmful; Ancel Keys' claims ignored contradictory evidence.Stopping statins often reverses side effects quickly, improving quality of life.Related episode:M&M 244: Seed Oils & Heart Disease: Oxidized LDL, Cholesterol, Fat & Cardiology | Tucker GoodrichReference Paper:LDL-C does not cause cardiovascular disease: a comprehensive review of the current literature*Not medical advice.Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts

In this episode, an episode about eating semisolid foods while experiencing a medical crisis, we zoom in on our featured Operator and Food, the styling stormswept seafaring fish doctor Lumen, who's delicate constitution needs to be warmly nurtured, and...Jello...who's scary...we ask the question...what flavor is she...scary flavor...? Then, bring out the band with Jade Noodles, Wiš'adel, and Phoenix Tail Prawn, asking a very important question of you, dear listener: Do you think the hardworking men who care for our communites, who care for our loved ones, our children and our qilin, deserve love, support, and nutrients of their own? We do. That's why Soul Mates! is a proud supporter of the #OatmealForYaoiDoctors movement, and we want you to be to. Share it on your social media, or with your friends and family. Don't let this important cause go unnoticed. Join the movement. Get it trending. #OatmealForYaoiDoctors Follow along:  https://arknights.wiki.gg/wiki/Lumen,  https://food-fantasy.fandom.com/wiki/Jello,  https://food-fantasy.fandom.com/wiki/Jade_Noodles,  https://arknights.wiki.gg/wiki/Wi%C5%A1%27adel,  https://food-fantasy.fandom.com/wiki/Phoenix_Tail_Prawn Support the show:  https://ko-fi.com/ivyfoxart Follow the show on Tumblr:  https://soul-mates-podcast.tumblr.com/ Follow the show on YouTube:  https://www.youtube.com/@Soul-Mates-Podcast Listen to Together We'll Shine: An Utena Rewatch Podcast:  https://bunnygirlbrainwave.substack.com/archive Art by Ryegarden:  https://www.instagram.com/ryegarden Music by Sueños Electrónicos:  https://suenoselectronicos.bandcamp.com/ Follow and support ash:  https://ko-fi.com/asherlark

-- On the Show: -- Donald Trump reverses his ceasefire stance after meeting Vladimir Putin and pressures Volodymyr Zelenskyy to accept land concessions without a ceasefire -- Trump fails to see Finnish President Alexander Stubb sitting directly in front of him and asks where he is during a public event -- Trump blames Barack Obama for losing Crimea and defends Vladimir Putin while dismissing Ukraine's NATO aspirations -- Trump praises Vladimir Putin during a red carpet meeting and blames Ukraine for getting invaded while downplaying Russia's aggression -- Wholesale vegetable prices surge nearly 40 percent in July raising fears of sharp increases in grocery costs for consumers -- Washington DC restaurant reservations plunge more than 25 percent after Donald Trump federalizes the police and militarizes the city -- Gavin Newsom rises in Democratic primary polls for 2028 after his redistricting efforts -- Fox News personalities criticize Gavin Newsom for mocking Trump online exposing hypocrisy about Trump's own years of ridicule -- On the Bonus Show: Texas Democrats monitored by law enforcement after returning to state, Trump vows to end mail-in voting, Ohio's Sherrod Brown launches bid for US Senate, and much more... ⚠️ Ground News: Get 40% OFF their unlimited access Vantage plan at https://ground.news/pakman

Send us a textThe appendix's hidden role and how "good" parasites like helminths shape immune health.Episode Summary: Dr. William Parker discusses gut anatomy, the appendix's role in harboring beneficial bacterial biofilms and immune tissue, and how modern hygiene depletes helminths (intestinal worms), causing immune overreactions like allergies, autoimmunity, and psychiatric conditions. He explores helminth self-therapy for treating relapsing MS, depression, and allergies; challenges in clinical trials due to patent issues; and why COVID-19 was milder in low-income, helminth-rich regions.About the guest: William Parker, PhD conducted research at Duke University for over 27 years on immunology, appendicitis, and the hygiene hypothesis. After retiring from Duke, he serves as a visiting scholar at the University of North Carolina at Chapel Hill, leading efforts on biome reconstitution via helminths.Discussion Points:Appendix is not vestigial; it concentrates immune tissue and biofilms to cultivate good gut bacteria, preventing pathogens via mucus and IgA antibodies.Hygiene hypothesis: Soap, toilets, and clean water reduce helminths/protozoa, leading to untrained, hyperactive immunity and rising allergies/autoimmunity since the 1800s.Helminths (worms) stimulate immune "exercise," training immunity; biohackers use hookworms (cheap, skin-entry), porcine whipworms, or rat tapeworms orally for relief from allergies, MS flares, depression/anxiety.Effects are temporary; need ongoing exposure (e.g., replenish every 6 months); immigrants from helminth-rich areas develop Western diseases within a few years.COVID-19: Hyper-immunity caused severe reactions in hygienic West, but helminth presence in low-income Africa/Asia prevented cytokine storms, leading to empty clinics.Therapy barriers: Non-patentable organisms require $100M+ trials; push for open-source, government-funded biome restoration over crude immunosuppressants.Related episode:M&M 144: Inflammation, Innate Immunity, Allergies & Allergens, Immune System Evolution, Fasting & Metabolism | Clare Bryant*Not medical advice.Support the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. For all the ways you can support my efforts

This week we're joined by Gillian Leitten, CEO of The Lumen Prize because today is that day that the 99 finalists for the Prize are announced (check the Show Notes) and Leitten is here to talk with us about the prize which celebrates artists forging new systems of meaning through technology's evolving creative frontier.We give a special focus on the Hybrid and Experiential categories, the later of which is the evolution of last year's Interactive/Immersive category and for the second year in a row features the most finalists of any category, 16 in total.SHOW NOTESThe Lumen PrizeThe 2025 Lumen Prize Finalists Hosted on Acast. See acast.com/privacy for more information.

This week we are airing another episode of Unconditional featuring the hilarious Ghosts star, Asher Grodman, to talk about his deep bond with his dog, Zazie. From her playful energy to her unwavering companionship, Asher shares how Zazie has been a grounding force in his life, especially during challenging times.   Sponsors: Go to  Lumen.me/pineapple for 15% off your purchase.Cornbread Hemp - Save 30% on your first order by going to ⁠cornbreadhemp.com/pineapple⁠ and use the code “pineapple” at checkout.Quince Cookware: ⁠quince.com/maggie⁠ for free shipping and 365 day returnsQuince Apparel: ⁠quince.com/pineapple⁠ for free shipping and 365 day returns Learn more about your ad choices. Visit megaphone.fm/adchoices

In the third hour, Dave Softy Mahler and Dick Fain chat with Larry Stone about the red hot Mariners, MVP race, Josh Naylor, and the fallout of the Portland Trailblazers sale, then discuss the Seahawks preseason plans for Friday and if Lumen Field is too old.See omnystudio.com/listener for privacy information.

Send us a textWhat is the core evolved function of the endocannabinoid system?Episode Summary: Dr. Giovanni Marsicano is a neuroscientist based in Bordeaux, France, where he leads a research group at INSERM focusing on the endocannabinoid system.About the guest: Giovanni Marsicano, PhD discusses the endocannabinoid system, starting with its core components like CB1 receptors and lipid-based molecules derived from omega-6 fatty acids; its cellular signaling, evolutionary role in energy storage for uncertain futures (exostasis vs. homeostasis); effects across tissues; motivation, appetite, pain relief, and anxiety regulation; biphasic effects of cannabinoids.Discussion Points:The endocannabinoid system acts as an "exostatic" regulator, promoting energy accumulation for future needs by enhancing food palatability, nutrient absorption, and fat storage, unlike "endostatic" systems that address immediate hunger.CB1 receptors appear in vertebrates with adipose tissue, suggesting an evolutionary link to storing fat for survival in unstable environments.Endocannabinoids are lipids from omega-6 fats; high intake boosts their levels, potentially fueling obesity by creating a self-perpetuating cycle of overeating.Activation of CB1 can have biphasic effects due to receptors on different cell types like excitatory vs. inhibitory neurons.Pregnenolone, a steroid precursor, acts as a natural CB1 inhibitor to prevent excessive activation, blocking harmful effects like psychosis from high THC doses.The system influences motivation beyond food, including sex and even human activities like sports or storytelling, by rewarding actions for potential future benefits.In the brain, CB1 on mitochondria and astrocytes modulates energy use, olfaction, and social stress transmission, with implications for disorders like Alzheimer's.Reference Paper:CB1 Receptor as the Cornerstone of ExostasisRelated episode:M&M 123: EndocanSupport the showAffiliates: Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. AquaTru: Reverse osmosis water filters. Remove metals, microbes, endocrine disruptors and toxins from drinking water. $100 off AquaTru filters through link. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) Lumen device to optimize your metabolism for weight loss or athletic performance. Code MIND for 10% off SiPhox Health—Affordable at-home blood testing. Key health markers, visualized & explained. Code TRIKOMES for a 20% discount. MASA Chips—delicious tortilla chips made from organic corn & grass-fed beef tallow. No seed oils or artificial ingredients. Code MIND for 20% off For all the ways you can support my efforts

-- On the Show: -- Inflation rose sharply in July under Trump's economy, driven by tariffs causing prices to increase above the Fed's ideal range -- Trump's firing of the Bureau of Labor Statistics head raises questions about the credibility and political influence on inflation and jobs data -- Layoffs in the US surged to the highest level since the COVID pandemic, fueled by federal job cuts, tariffs, AI automation, and private sector downsizing -- Trump's takeover of DC police and deployment of National Guard troops sparked protests and potential resistance from the Guard -- Trump's strange remarks about sidewalk scrubbing during a speech leave his staff bewildered -- Trump's FBI Director Kash Patel publicly contradicted MAGA narratives by reporting record low murder rates, enraging Trump -- Donald Trump confused Alaska with Russia during a speech, exposing incoherence and hypocrisy in right-wing media responses -- Trump's press secretary Karoline Leavitt had a visible meltdown on camera when asked a simple question about the Epstein scandal -- Marjorie Taylor Greene publicly attacks other MAGA figures, exposing internal conflict and power struggles within the movement -- Jeanine Pirro struggled when confronted with real crime data showing declines, undermining the MAGA narrative -- Defense Secretary Pete Hegseth dodged questions about the fate of homeless people after Trump's plans to clear homeless encampments -- On the Bonus Show: Pete Hegseth retweets Christian nationalist pastor, Project 2025 guy picked for BLS leader, MTG accused of sketchy stock trading, and much more...

-- On the Show: -- Donald Trump lashes out with angry social media posts as economic indicators show signs of decline -- Donald Trump fired Bureau of Labor Statistics head Erika McEntarfer after a devastating jobs report exposed major economic weakness -- Republican Senators like Cynthia Lummis and Thom Tillis finally criticize Donald Trump after he Bureau of Labor Statistics head Erika McEntarfer for political reasons -- Donald Trump's DOJ moved Ghislaine Maxwell to minimum-security after a secret meeting, raising serious questions about favors and Epstein connections -- Donald Trump was loudly booed by thousands at WWE SummerSlam during a video appearance, showing a shocking drop in support -- Donald Trump made disturbing comments about press secretary Karoline Leavitt's lips on TV, raising concerns about sexism and power abuse -- Press secretary Karoline Leavitt demanded Trump receive the Nobel Peace Prize, pushing the cult of personality narrative to absurd heights -- Donald Trump discusses the Epstein files, pardons, drug prices, and lashes out about loyalty and job numbers -- MAGA spokespeople struggle to defend Trump's false economic claims amid historic job report revisions -- Trump lashes out on Truth Social accusing Biden appointees of rigging jobs data and demands firings while denying economic reality -- Trump claims he fired a government official over disputed jobs numbers and insists on having trusted personnel amid growing economic uncertainty -- A leaked DHS memo reveals plans to militarize immigration enforcement domestically, alarming experts about authoritarian risks -- Newsmax spins July jobs report disaster as “good news” ignoring massive downward revisions and recession fears -- On the Bonus Show: Trump attacks Charlamagne tha God, Tesla's brand loyalty plummets, Nancy Mace announces run for Governor of South Carolina, and much more... ⚠️ Ground News: Get 40% OFF their unlimited access Vantage plan at https://ground.news/pakman

The Trump EPA radically revises regulations over greenhouse gas emissions, and we're joined by Energy Secretary Chris Wright to discuss the energy revolution; Cory Booker gets performative on the Senate floor; and The New York Times admits a horrifying screw-up in its Gaza coverage. Click here to join the member-exclusive portion of my show: https://bit.ly/3WDjgHE Ep.2249 - - - Facts Don't Care About Your Feelings - - - DailyWire+: Watch Journey to the UFC: Joe Pyfer now—streaming exclusively on DailyWire+. My new book, “Lions and Scavengers,” drops September 2nd—pre-order today at https://dailywire.com/benshapiro Get your Ben Shapiro merch here: https://bit.ly/3TAu2cw - - - Today's Sponsors: Perplexity - Perplexity is an AI-powered answer engine that searches the internet to deliver fast, unbiased, high-quality answers, with sources and in-line citations. Ask Perplexity anything here: https://pplx.ai/benshapiro PureTalk - Switch to PureTalk and start saving today! Visit https://PureTalk.com/SHAPIRO Lumen - Go to https://lumen.me/SHAPIRO to get 10% off your Lumen. CovePure - Go to https://covepure.com/shapiro to get $200 off. One Nation America - Learn more at https://OneNationAmerica.org - - - Socials: Follow on Twitter: https://bit.ly/3cXUn53  Follow on Instagram: https://bit.ly/3QtuibJ  Follow on Facebook: https://bit.ly/3TTirqd  Subscribe on YouTube: https://bit.ly/3RPyBiB - - - Privacy Policy: https://www.dailywire.com/privacy Learn more about your ad choices. Visit megaphone.fm/adchoices

The Trump EPA radically revises regulations over greenhouse gas emissions, and we're joined by Energy Secretary Chris Wright to discuss the energy revolution; Cory Booker gets performative on the Senate floor; and The New York Times admits a horrifying screw-up in its Gaza coverage. Click here to join the member-exclusive portion of my show: https://bit.ly/3WDjgHE Ep.2249 - - - Facts Don't Care About Your Feelings - - - DailyWire+: Watch Journey to the UFC: Joe Pyfer now—streaming exclusively on DailyWire+. My new book, “Lions and Scavengers,” drops September 2nd—pre-order today at https://dailywire.com/benshapiro Get your Ben Shapiro merch here: https://bit.ly/3TAu2cw - - - Today's Sponsors: Perplexity - Go to https://helixsleep.com/klavan to get an exclusive discount. PureTalk - Switch to PureTalk and start saving today! Visit https://PureTalk.com/SHAPIRO Lumen - Go to https://lumen.me/SHAPIRO to get 10% off your Lumen. CovePure - Go to https://covepure.com/shapiro to get $200 off. One Nation America - Learn more at https://OneNationAmerica.org - - - Socials: Follow on Twitter: https://bit.ly/3cXUn53 Follow on Instagram: https://bit.ly/3QtuibJ Follow on Facebook: https://bit.ly/3TTirqd Subscribe on YouTube: https://bit.ly/3RPyBiB - - - Privacy Policy: https://www.dailywire.com/privacy

Director of National Intelligence Tulsi Gabbard declassifies a House Intelligence Committee report showing the Obama team doctored intel to conclude that Russia wanted Trump in 2016; journalist Michael Tracey joins us to discuss what's actually in the Epstein files; and President Trump brings Columbia University to heel.Click here to join the member-exclusive portion of my show: https://bit.ly/3WDjgHEEp.2245- - -Facts Don't Care About Your Feelings- - -DailyWire+:Right now you can gift Daily Wire plus for 40% off with code JULY at DailyWire.com/gift (https://www.dailywire.com/gift).My new book, “Lions and Scavengers,” drops September 2nd—pre-order today at https://dailywire.com/benshapiroGet your Ben Shapiro merch here: https://bit.ly/3TAu2cw- - -Today's Sponsors:ExpressVPN - Go to https://expressvpn.com/ben and find out how you can get 4 months of ExpressVPN free!Cookunity - Go to https://www.cookunity.com/benfree for Free Premium Meals for Life. Thanks to CookUnity for supporting the show!Policygenius - Head to https://policygenius.com/SHAPIRO to get your free life insurance quotes and see how much you could save.Lumen - Go to https://lumen.me/SHAPIRO to get 10% off your Lumen.One Nation America - Learn more at https://OneNationAmerica.org- - -Socials:Follow on Twitter: https://bit.ly/3cXUn53Follow on Instagram: https://bit.ly/3QtuibJFollow on Facebook: https://bit.ly/3TTirqdSubscribe on YouTube: https://bit.ly/3RPyBiB- - -Privacy Policy: https://www.dailywire.com/privacy

-- On the Show: -- Jimmy Gomez, Democratic Congressman representing California's 34th Congressional District, joins David to discuss ICE raids, deportations, and Trump sending troops to Los Angeles -- Trump was personally briefed by Pam Bondi that his name appears in the Epstein files, which were then sealed by his DOJ -- Trump's defense lawyer was sent to meet Ghislaine Maxwell as Congress prepares the Epstein subpoenas -- Tulsi Gabbard leads Trump's latest disinformation push, targeting Barack Obama with unproven coup allegations -- Trump melts down on Truth Social as legal and political crises mount -- Tulsi Gabbard's comments contradict MAGA beliefs about Epstein's CIA ties, causing chaos in the base -- Karoline Leavitt fumbles questions on Epstein, AI, and Obama prosecutions in a disastrous press conference -- Trump's tech speech devolves into nonsense about AI, GDP, and “woke” staff -- Trump calls for Obama's arrest, ignoring that presidential immunity he fought for would protect Obama too -- On the Bonus Show: Trump floats no tax on home sales, EPA says greenhouse gases are fine, Macrons sue Candance Owens for defamation, and much more...

Declassified Obama-era emails yield new revelations about the Trump-Russia probe, President Trump sues the WSJ over an alleged connection to Epstein, and a bipartisan bill in Congress would shield millions of illegal immigrants from deportation. Get the facts first with Morning Wire. - - - Today's Sponsors: Lumen - Go to https://lumen.me/WIRE to get 10% off your Lumen. Shopify - Go to https://Shopify.com/morningwire to sign up for your $1 per month trial period and upgrade your selling today. - - - Privacy Policy: https://www.dailywire.com/privacy

Trump shifts his policy on aid to Ukraine while threatening Putin, the midterms may spell trouble for the GOP, and Biden breaks his silence over the investigations into his autopen use. Get the facts first with Morning Wire. - - - Today's Sponsors: Balance of Nature - Go to https://balanceofnature.com and use promo code WIRE for 35% off your first order as a preferred customer PLUS get a free bottle of Fiber and Spice. Lumen - Go to https://lumen.me/WIRE to get 10% off your Lumen. - - - Privacy Policy: https://www.dailywire.com/privacy

Joe Biden's doctor takes the Fifth when asked whether Biden was healthy or not; President Trump's team undercuts him on Ukraine's defense; and the administration targets California for failing to defend girls in sports. Click here to join the member-exclusive portion of my show: https://bit.ly/3WDjgHE Ep.2235 - - - Facts Don't Care About Your Feelings - - - DailyWire+: Join millions of people who still believe in truth, courage, and common sense at https://DailyWirePlus.com. My new book, “Lions and Scavengers,” drops September 2nd—pre-order today at https://dailywire.com/benshapiro Get your Ben Shapiro merch here: https://bit.ly/3TAu2cw - - - Today's Sponsors: ExpressVPN - Go to https://expressvpn.com/ben and find out how you can get 4 months of ExpressVPN free! SimpliSafe - Visit https://SIMPLISAFE.com/SHAPIRO to claim 50% off a new system with a professional monitoring plan and get your first month free. Lumen - Go to https://lumen.me/SHAPIRO to get 10% off your Lumen. IFCJ - To learn more about IFCJ's lifesaving work, visit https://benforthefellowship.org Birch Gold - Text BEN to 989898 for your free information kit.  - - - Socials: Follow on Twitter: https://bit.ly/3cXUn53 Follow on Instagram: https://bit.ly/3QtuibJ Follow on Facebook: https://bit.ly/3TTirqd Subscribe on YouTube: https://bit.ly/3RPyBiB - - - Privacy Policy: https://www.dailywire.com/privacy

President Trump fields questions on tariffs, Ukraine, and Epstein during his sixth Cabinet meeting, fallout continues from the Central Texas floods, and the Administration rejects amnesty but hints at flexibility for some illegal immigrant workers. Get the facts first with Morning Wire. - - - Today's Sponsors: Zocdoc - Find and instantly book a top-rated doctor today. Visit https://Zocdoc.com/WIRE #sponsored Lumen - Go to https://lumen.me/WIRE to get 10% off your Lumen. - - - Privacy Policy: https://www.dailywire.com/privacy

Trump secures increased funding from NATO members, Senate Republicans consider the One Big Beautiful Bill, and a therapy student blows the whistle on mandatory training in smut. Get the facts first with Morning Wire. - - - Today's Sponsors: Lumen - Go to https://lumen.me/WIRE to get 10% off your Lumen. Lean - Get 20% off when you enter MORNINGWIRE20 at https://TakeLean.com - - - Privacy Policy: https://www.dailywire.com/privacy

President Trump lays out his final ultimatum: he'll make a call on attacking Iran's nuclear facilities within two weeks; we analyze all the various possibilities; and why are people falling in love with their AI chatbots? Click here to join the member-exclusive portion of my show: https://bit.ly/3WDjgHE Ep.2222 - - - Facts Don't Care About Your Feelings - - - DailyWire+: Join millions of people who still believe in truth, courage, and common sense at https://dailywireplus.com My new book, “Lions and Scavengers,” drops September 2nd—pre-order today at https://dailywire.com/benshapiro Get your Ben Shapiro merch here: https://bit.ly/3TAu2cw - - - Today's Sponsors: Perplexity - Perplexity is an AI-powered answer engine that searches the internet to deliver fast, unbiased, high-quality answers, with sources and in-line citations. Ask Perplexity anything here: https://pplx.ai/benshapiro ExpressVPN - Go to https://expressvpn.com/ben and find out how you can get 4 months of ExpressVPN free! Lumen - Go to https://lumen.me/SHAPIRO to get 10% off your Lumen. SimpliSafe - Visit https://SIMPLISAFE.com/SHAPIRO to claim 50% off a new system with a professional monitoring plan and get your first month free. Shopify - Sign up for your one-dollar-per-month trial and start selling today at https://shopify.com/shapiro - - - Socials: Follow on Twitter: https://bit.ly/3cXUn53 Follow on Instagram: https://bit.ly/3QtuibJ Follow on Facebook: https://bit.ly/3TTirqd Subscribe on YouTube: https://bit.ly/3RPyBiB - - - Privacy Policy: https://www.dailywire.com/privacy