Podcasts about Virulence

Microbes can work work together .... if the conditions are favourable for cooperation. An understanding of quorum sensing offers new perspectives, and thus, treatment perspectives that may decrease disease severity without contributing to antibiotic resistance. The information presented on this podcast is for educational purposes only and is not intended to diagnose or prescribe for any medical or psychological condition, nor prevent, treat, mitigate, or cure any conditions. Please make your own healthcare decisions based on your judgment and research in partnership with a qualified healthcare professional.Become a supporter of this podcast: https://www.spreaker.com/podcast/that-naturopathic-podcast--4229492/support.

Today in Bonus Feed Land, friend of the show Shaun Corley takes Nat on a historical jaunt through a catalog of Marvel's earliest anticommunist stories and characters all the way up to some of their more recent racist depictions of dastardly foreigners. Find the full episode on the Patreon! (A contribution to MECA has been made in Shaun's name in appreciation for his appearance on the show.) BIG APOLOGIES FOR THE AUDIO QUALITY. Nat was trying something new, and boy howdy did it not work. https://screenrant.com/author/shaun-corley/ https://www.instagram.com/corleyontheshore/ ---------- Email: collectiveactioncomics@gmail.com Instagram: https://www.instagram.com/collectiveactioncomics Twitter: https://twitter.com/CAComixPod Patreon: https://www.patreon.com/collectiveactioncomics

Historia original escrita por Leigh Ann (u-lala-lation): My neighborhood is searching for a new father who's gone missing. I found his Reddit… : nosleep Instagram: Darksoul (@darksoulhorror) • Fotos y videos de Instagram Música: MYUU- Fading REPULSIVE - Secret From The River, Wings, Dear Friend, You Couldn't Live For Very Long Without Heart, Cry Of The Unheard, Virulence

Be Skeptikal Dammit:  Counterfeit Drug Puts Australians in Hospital Environment:  Plastics in the Ocean Help Make Pathogens More Virulent Main and Positive:  I Made it to 100! Show Notes: Fake weight loss drug   https://www.bbc.com/news/world-europe-67217729   https://www.theguardian.com/australia-news/2023/jan/06/tga-investigates-influencers-after-diabetes-drug-ozempic-promoted-as-weight-loss-treatment   https://au.news.yahoo.com/aussie-husbands-plea-after-wife-dies-trying-to-lose-weight-for-daughters-wedding-213812998.html?guccounter=1&guce_referrer=aHR0cHM6Ly93d3cuZ29vZ2xlLmNvbS8&guce_referrer_sig=AQAAAB3zLoNcLsTo-lHQBSVhI6fRBebNJng5GCvnTcUt_XObO8ayImGMS4lC4R7dd5TxJp9-Im-QKHUuFEszQJBVSX8EYHPnTbKgR7WurYXjs5cMR8cBTotOu_F8btjFbiEp73HwDfExFwz1TkxicUdCZcZpYaHqH0q52RduiDwYYT9l   micro plastic exposure makes microbes more virulent   https://www.smithsonianmag.com/science-nature/microplastic-exposure-makes-microbes-more-virulent-180982436/#:~:text=The%20scientists%20aren't%20exactly,in%20resistance%20to%20all%20antimicrobials.   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9963316/   https://www.sciencedirect.com/science/article/pii/S0269749123005602   synthetic sponges soak up microplatics   https://www.smithsonianmag.com/innovation/scientists-have-created-synthetic-sponges-that-soak-up-microplastics-180983017/   https://greencitizen.com/news/synthetic-sponges-show-promise-in-microplastic-removal-efforts/   https://www.fastcompany.com/90744494/microplastics-are-everywhere-these-sponges-could-help-capture-them     THAT'S IT.  REST WILL BE SHARING; STATS, FAVES, ETC.

For the last episode of 2023, TWiV describes how ancient chicken remains reveal the increase of fitness and virulence of Marek's disease virus, and the diversity and dissemination of Leishmania virus in the pathogenic protozoan Leishmania braziliensis. Hosts: Vincent Racaniello, Dickson Despommier, Kathy Spindler, Brianne Barker and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Become a member of ASV (asv.org) Research assistant position in Rosenfeld Lab CBER/FDA (pdf) The New City by Dickson Despommier Ancient chickens and Marek's disease virus (Science) Diversity and dissemination of Leishmania virus and L. braziliensis (Nat Comm) Letters read on TWiV 1074 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Addictive Mandelbrot video and Gore slams COP28 summit Angela – 10 top-trending health questions you had for Dr. Google in 2023 Brianne – Tomato lost in space has been found Kathy – Earthquakes of the 20th Century Vincent – Animator Chris Georgenes especially Tricycle animation study Listener Picks Jason – Spot-on, quick booster explainer and “Inverse” vaccine Slashdot's summary. the full article, primary research article Meika – Iceland earthquake site Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

The journey to optimal health begins in the gut. Understanding the intricate balance within the digestive system is crucial for overall well-being. Gut health impacts not only digestion but also influences the immune system, hormonal balance, and even mental health. The GI Microbial Assay Plus or GI Map is a revolutionary diagnostic tool that provides a comprehensive analysis of gut health. This presentation explores how this test unveils hidden aspects of digestive well-being. Show Notes: 2:30 - Sample Collection 4:45 - Commensal or keystone bacteria 7:18 - Opportunistic bacteria 10:25 - H.pylori - common in about half the world's population 12:35 - Virulence factors making the environment more suitable for bacterial overgrowth 13:12 - Viruses and yeast like candida 14:20 - Parasites and worms and difficulty in treating 15:15 - Other intestinal health markers that show if there is digestive dysfunction 18:00 - GI Map Mini Program to start your health journey Follow us on IG ⁠⁠⁠⁠@functionallyenlightened⁠⁠⁠⁠ to be notified when new interviews with amazing functional practitioners and chronic illness warriors are published or to hear more prayer points. Visit www.functionallyenlightened.com for information on how we work or to subscribe to our newsletter. --- Send in a voice message: https://podcasters.spotify.com/pod/show/functionallyenlightened/message

Hugues de ThéCollège de France - Année 2023-2024Oncologie cellulaire et moléculaireColloque - Journée François Jacob : La vie sociale des microbes - The Ecology and Evolution of E. Coli VirulenceIntervenant(s)François Blanquart, Chercheur, Centre interdisciplinaire de recherche en biologie (CIRB - «Épidémiologie évolutive des maladies infectieuses») – CRCN, CNRSLes Journées François JacobLes Journées François Jacob, organisées par l'Institut de Biologie du Collège de France, rassemblent chaque année les meilleurs spécialistes français et étrangers autour d'un thème à la pointe des enjeux de la recherche en biologie.Le lauréat du prix Antoine Lacassagne, attribué chaque année par le Collège de France à un chercheur en biologie, est traditionnellement invité à recevoir son prix lors des Journées François Jacob et à y donner un séminaire en relation avec ses travaux.Ces journées sont nommées en l'honneur de François Jacob, titulaire de la chaire Génétique cellulaire du Collège de France (1964-1991), prix Nobel de physiologie ou médecine 1965 avec André Lwoff et Jacques Monod pour la découverte de la régulation génétique de la synthèse des enzymes et des virus.

In this edition of Frikkity Frak, We Do Talk Back, we discuss the episode "The Future Virulence" from Bleach:TYBW and connect it to Psalm 97:10. Please rate, subscribe, and review this podcast, tell your friends, and if you have any questions, please contact us at frikkityfraktalkback@gmail.com or any of our social media accounts with any questions about this episode or any and all spiritual, nerdy, or general questions. @FrikkityF on Twitter@FrikkityFrak on Instagram@FrikkityFrak on Facebook --- Send in a voice message: https://podcasters.spotify.com/pod/show/frikkityfrak/message

The alteration of virulence factors of Streptococcus complicates the selection of isolates for vaccine formulation. In this episode, Dr. Smith explains that individual serotypes may vary in their susceptibility to damage or neutralization by vaccines, which adds complexity to the identification of the causative serotypes. Learn more about the issue in this episode, with Dr. Strobel and Dr. Smith.The Swine it Podcast Show is trusted and supported by innovative companies like:-Adisseo-Evonik-AB Vista-Genesus-CloudFarms-Bioverse (Healthy farms)-Schippers-Eastman

Histamine intolerance is a growing concern, but confusion still surrounds its prevalence, diagnosis and treatment. Certainly histamine is far more than a biogenic amine which causes runny nose, flushing and other allergy symptoms. Indeed, histamine is involved in a diverse array of metabolic processes from regulation of temperature, normal sebum production and stomach acid release to estrogen metabolism, acne, brain fog and a multitude of gastrointestinal symptoms often ascribed to other conditions. Today Joanne Kennedy takes us through her clinical experience with histamine intolerance and what drove her to write an eBook and other resources for practitioners to learn about this confounding condition.REFERENCES:Maintz L, Novak N. Histamine and histamine intolerance. Am J Clin Nutr. 2007;85:1185-1196. [Full Text] Erdag D, Merhan O, Yildiz B. Proestos C, editor. Biogenic Amines [Internet]. IntechOpen; 2019. Comas-Basté O, Sánchez-Pérez S, Veciana-Nogués MT, et al. Histamine Intolerance: The Current State of the Art. Biomolecules. 2020 Aug;10(8):1181. [Full Text]  Schnedl WJ, Enko D. Histamine Intolerance Originates in the Gut. Nutrients 2021;13:1262. [Full Text]Zhao A, Sun J, Liu Y. Understanding bacterial biofilms: From definition to treatment strategies. Front Cell Infect Microbiol. 2023;13:1137947. [Full Text]  Roy R, Tiwari M, Donelli G, et al. Strategies for combating bacterial biofilms: A focus on anti-biofilm agents and their mechanisms of action. Virulence. 2018;9(1):522-554. [Full Text] Mohamed SH, Mohamed MSM, Khalil MS, et al. Combination of essential oil and ciprofloxacin to inhibit/eradicate biofilms in multidrug-resistant Klebsiella pneumoniae. J Appl Microbiol. 2018 Jul;125(1):84-95. [Abstract] Schnedl WJ, Schenk M, Lackner S, et al. Diamine oxidase supplementation improves symptoms in patients with histamine intolerance. Food Sci Biotechnol. 2019 Dec; 28(6): 1779–1784. [Full Text]  Kettner L, Seitl I, Fischer L. Toward Oral Supplementation of Diamine Oxidase for the Treatment of Histamine Intolerance. Nutrients 2022;14:2621. [Full Text]  Selvam T, Schwieger W, Dathe W. Histamine-binding capacities of different natural zeolites: a comparative study. Environ Geochem Health. 2018;40:2657-2665. [Full Text] 

Emission 864 Fu Manchu ce sont… Des courses de buggies dans les dunes - L'esprit skate des années Alva-Peralta - De vieilles Camaro vintage - Des filles en bikini - De possibles rencontres extraterrestres - Des vans customisés comme mode d'itinérance - avec leurs dégaines de néo-babas surfers, ces caricatures de slackers californiens ont pourtant démarré à l'adolescence dans le hardcore (avec Virulence en 1985) pour évoluer dès l'entame des années 90's vers un modèle copié par des myriades de suiveurs avec un son unique, enveloppé d'une fuzz épaisse, soutenues par une basse non moins volumineuse   La Playlist: Sleestak – (J) – Wurkin - Neptune's Convoy - Missing Link (J) – The Solid Hex - Seaharg – Urethane – (J) - Burning Road - Trackside_Hoax – Evil Eye – Laserbl ast ! - (J) - Saturn III - Godzilla – Pigeon Toe - (J) – Mongoose - Freedom of Choice - Downtown In Dogtown - We Must Obey – (J)- Knew It All Along - Moving In Stereo – (J) - Sensei Vs Sensei - Dimension shifter – (J) - The Last Question - Il_Mostro_Atomico Bonne Ecoute...   Bibliographie : New Noise n°22 Juillet Août 2014 New Noise n°29 sept oct 2015 New Noise n°31 janv fév 2016 New Noise n°50 sept oct 2019 New Noise n°51 nov déc 2019

英语新闻｜新型变异毒株“地狱犬”来了？中疾控回应The BQ.1 subvariant of Omicron has emerged on the mainland but no marked increase in its pathogenicity has been reported, and reinfection with COVID-19 does not increase the risk of severe illness, health officials and experts said. 卫生官员和专家表示，奥密克戎的亚分支BQ.1已在中国大陆出现，但其致病性没有明显增加，新冠肺炎的二次感染不会增加重症风险。The mainland has reported 49 cases of BQ.1 or its sublineages in nine provincial-level regions. However, no widespread transmission has been reported and no infected patients have been found to suffer more severe symptoms compared with patients who've contracted other variants.目前我国已在9个省份的本土病例中检出BQ.1及其亚分支49例，但尚未广泛流行，所致病例数较少，也未观察到感染BQ.1后临床严重程度较其它变异株增加。"Currently, the dominant strains in circulation in China remain BA.5.2 and BF.7, and both are sublineages of BA.5," the Chinese Center for Disease Control and Prevention said on Tuesday.“我国现阶段流行的毒株仍以BA.5的亚分支BA.5.2和BF.7为主。”中国疾病预防控制中心12月13日表示。The center made the statement in response to online rumors that BQ.1 and its offshoots were wreaking havoc in Japan with their high transmissibility and high death rates.网络流传消息称，一种名为BQ.1.1的新型变异毒株在日本“杀疯了”，该毒株的传染性和致死率都很高。中国疾控对此做出了回应。BQ.1, which also belongs to the BA.5 family, was first detected in Nigerian patients in June and began spreading in September in Europe and the United States, and gradually rose to become the dominant variant. Since mid-October, Asian countries, including Japan and Singapore, have been registering BQ.1 infections.BQ.1是奥密克戎BA.5的亚分支，2022年6月在尼日利亚感染者中发现，9月开始BQ.1及其衍生的子代亚分支在欧美国家流行，占比逐月升高，10月中旬在日本和新加坡等亚洲国家逐渐开始流行。"While BQ.1 has drawn global attention, no country has ever reported an increase in its pathogenicity, and no report has pointed to an increase in rates of hospitalization and fatality," said the center. "A recent animal study in Japan suggests that the pathogenicity of BQ.1.1(a lineage of BQ.1) is likely the same as or even lower than that of BA.5."“BQ.1虽然引起全球范围的关注，目前，未见任何国家报道BQ.1及其亚分支感染者的致病力增加，也无住院率和病死率增加的报道。近期日本的一项动物研究显示，BQ.1.1的致病性可能与BA.5相同或更低。”中国疾病预防控制中心指出。The center said that China will continue to ramp up surveillance of Omicron variants and promptly evaluate transmissibility, immunity evasiveness and virulence of new strains.该中心表示，我国将继续加强对奥密克戎变异株的基因组变异变迁监测，对新出现的传播优势毒株，及时开展传播力、免疫逃逸能力和致病力的评估。Because the virus is constantly mutating, the National Health Commission said on Tuesday that recovered COVID-19 patients are not immune to repeat infections.12月13日，国家卫生健康委员会表示，奥密克戎可能快速变异出新的亚分支，出现较强的免疫逃逸能力，康复者不能完全避免二次感染。"However, data from overseas has shown that the chance of getting infected with Omicron again within three to six months after the first bout is very low," the commission said.卫健委表示：“不过，国外有统计数据显示，感染过奥密克戎，不管有无症状，3至6个月内二次感染的概率相当低。”In addition, the commission said there is no definitive evidence supporting the theory that repeat infections can induce more serious clinical symptoms.此外，卫健委表示，目前没有定论认为重复感染会出现更严重的临床结果。"Based on observation of real-world cases, the proportion of patients who have suffered more serious health issues during a second infection is very low," the commission said. 卫健委表示，“目前病例来看，患者在重复感染时出现症状加重的倾向，这一比例非常低”。"The pathogenicity of Omicron has weakened, and the rate of severe cases is very low irrespective of being a first infection or repeat infection."“奥密克戎病毒致病力在减弱，不论是第一次感染，还是再感染，发生重症的概率都很低。”Zhong Nanshan, a prominent respiratory diseases expert, said during an interview last week that data from overseas has shown about 78 percent of patients who have recovered from Omicron infection won't catch the virus again for a lengthy period of time.著名呼吸系统疾病专家钟南山上周在接受采访时说，据国外资料显示，一旦感染过奥密克戎，不管有无症状，有78%的人在相当长时间内不会再重复感染。Pathogenicity英 [ˌpæθədʒeˈnɪsɪti] 美 [ˌpæθoʊdʒəˈnɪsɪti]n.致病性Virulence 英 [ˈvɪrələns] 美 [ˈvɪrələns]n.毒性bout英 [baʊt] 美 [baʊt]n.发作，发病期

Janet Smith, a professor at the University of Michigan Medical School, associate director of the UM Life Sciences Institute and scientific director of the GM/CA beamlines at the Argonne synchrotron, won the 2022 Mildred Cohn Award in Biological Chemistry, which honors scientists at all stages of their careers who have made substantial advances in understanding biological chemistry using innovative physical approaches. She presented her award lecture, "Flavivirus NS1: Structure and function of an enigmatic virulence factor," on Monday, April 4, at the 2022 ASBMB Annual Meeting, held in conjunction with Experimental Biology in Philadelphia. Learn more about her work: https://www.asbmb.org/asbmb-today/people/121721/smith-unravels-secrets-of-nature-s-catalysts.

Staphylococcus aureus is a versatile pathogen that infects many areas of the body and has a number of strategies for avoiding the immune response. In this episode, Niki Spahich from The Scientist's Creative Services team spoke with Anthony Richardson, an associate professor of microbiology and molecular genetics at the University of Pittsburgh, to learn how the bacterium fine-tunes its metabolism to survive in the host and why Staph's metabolism makes it especially dangerous for people with diabetes.

Part 2It's imperative for poultry producers and companies to know what strains of Salmonella may be circulating in their flocks, said Chuck Hofacre, president of the Southern Poultry Research Group in Georgia. Chapters:0:00 Intro - The prevalent serotypes of Salmonella that cause illness in humans are changing0:40 Chuck Hofacre, President, Southern Poultry Research Group1:08 Monitoring programs for Salmonella2:28 Boot socks use in testing the environment for Salmonella shedding3:35 Testing at the hatchery4:42 Consistency of tests between farm and processing plant5:36 Prevalence of Salmonella Infantis and other serotypes6:33 Controlling Salmonella Infantis8:04 Virulence of Salmonella Kentucky9:09 Current FSIS regulations for Salmonella testing_________________________Poultry Health Today is a news publication sponsored by Zoetis designed to bring broiler, layer and turkey producers the latest news and insights on poultry health, welfare, performance and sustainability. Visit us at PoultryHealthToday.com and follow us on LinkedIn, Facebook and Twitter. For more on our sponsor, visit Zoetis.com.

Kelly ReganBuy American! - http://switchtoamericanow.com/Melagal61 The Free America PodcastWebsite - https://www.freeamericapodcast.com/Bitchute - https://www.bitchute.com/channel/XUMguOqsBvbm/Rumble - https://rumble.com/user/FreeAmericaPodcastAlternate Social MediaGab - https://gab.com/FreeAmericaPodcastMewe - https://mewe.com/i/freeamerica2Action ItemsCalifornia Calls in Sick Vaxxed Nurses to Fill Self-Created Shortage - https://www.thegatewaypundit.com/2022/01/firing-unvaxxed-healthcare-workers-california-tells-covid-positive-medical-workers-stay-job/Texas Scientists Develop A True Vaccine, Patent-Free - https://www.theguardian.com/us-news/2022/jan/15/corbevax-covid-vaccine-texas-scientistsA Lesson in Identifying PropagandaNY Times Claims Unvaccinated Cases Rise, But Show 'Not Fully Vaccinated' Stats - https://www.theguardian.com/us-news/2022/jan/15/corbevax-covid-vaccine-texas-scientistsABC News Falsely Debunks 120 Years of Established Science by Citing Ghost 'Experts' - https://abcnews.go.com/Health/debunking-idea-viruses-evolve-virulent/story?id=82052581NPR Blames Everything but the Vaccine, Including Climate Change, for Store Shortages - https://www.npr.org/2022/01/12/1072462477/grocery-shortage-shelves-reasons

References Oral Microbiol Immunol. 2006 April 21 (2):84-92 1647-6017 Infect Immun. 2018 Jul; 86(7): e00035-18 --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support

References J Dent Res. 2019 Nov;98(12):1315-1323 ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 1996.Vol. 335, No. 1, November 1, pp. 102–108,. Nature Reviews Microbiology. 2003. volume 1, pages219–230 Front. Microbiol. 2021. 14 July --- Send in a voice message: https://anchor.fm/dr-daniel-j-guerra/message Support this podcast: https://anchor.fm/dr-daniel-j-guerra/support

The TWiV team reviews the observation that infection with the SARS-CoV-2 Omicron variant causes reduced reproduction and pathogenesis in mice and hamsters. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Brianne Barker, and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine Town Hall (ASV) Travel Award Applications (ASV) Omicron infection in mice and hamsters (Res Square) Letters read on TWiV 851 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Engineering the James Webb Space Telescope Amy – T cells might be our bodies' best shot against Omicron Brianne – Where is Webb? Rich – First U.S. vaccine mandate in 1809 launched 200 years of court battles Vincent – The Secret of Life by Howard Markel Listener Picks Jen – Antidote David – Rosie Revere, Engineer Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

The TWiV team reviews the observation that infection with the SARS-CoV-2 Omicron variant causes reduced reproduction and pathogenesis in mice and hamsters. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Brianne Barker, and Amy Rosenfeld Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine Town Hall (ASV) Travel Award Applications (ASV) Omicron infection in mice and hamsters (Res Square) Letters read on TWiV 851 Timestamps by Jolene. Thanks! Weekly Picks Dickson – Engineering the James Webb Space Telescope Amy – T cells might be our bodies' best shot against Omicron Brianne – Where is Webb? Rich – First U.S. vaccine mandate in 1809 launched 200 years of court battles Vincent – The Secret of Life by Howard Markel Listener Picks Jen – Antidote David – Rosie Revere, Engineer Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv

Let's review the long-known law of declining virulence which describes how viruses evolve to become less virulent over time as they infect more hosts. Save your seat in the Blood Work MasterClass, our next meeting is Tuesday, Nov 30th at 5:00 PM PST. https://courses.highintensityhealth.com/store/hgwDdo2p Links to must read research: https://bit.ly/3liYIAB Episode Time Stamps: 3:15 Viruses mutate as they infect more hosts 3:40 Viruses are intracellular parasites 6:20 The law of Declining Virulence 7:25 RNA Viruses have high mutation rates 9:25 Are vaccines accelerating viral evolution? 11:45 The law of Declining Virulence details 14:05 Mild infections are selected for 16:00 Rising childhood infections are signs of endemicity 18:00 Russian flu pandemic of 1889 21:00 Mass vaccination during a roaring pandemic

Guest: Elitza S. Theel, Ph.D. (@ElliTheelPhD) Host: Amit K. Ghosh, M.D. (@AmitGhosh006) Dr. Elitza Theel, Professor of Laboratory Medicine and Pathology and Director of Infectious Diseases Serology Laboratory at Mayo Clinic's Rochester Campus, discusses our immune response to vaccination and natural infection and outlines the different types of antibody assays currently available. Dr. Theel also discusses the concept of herd immunity in the context of different circulating SARS-CoV-2 variants and the increased need to get higher rates of vaccination in the community as the infectivity and transmissibility of circulating SARS-CoV-2 variants changes. We also discuss the status of correlates of protective immunity against SARS-CoV-2 and the need for booster vaccine doses for immunocompromised individuals.  Additional resources: Interim Guidelines for COVID-19 Antibody Testing in Clinical and Public Health Settings https://www.cdc.gov/coronavirus/2019-ncov/lab/resources/antibody-tests-guidelines.html Connect with the Mayo Clinic's School of Continuous Professional Development online at https://ce.mayo.edu/ or on Twitter @MayoMedEd.

Let's review a the long known law of declining virulence which describes how viruses and parasites evolve to become less virulent over time as they infect more hosts. Support your Sleep and Electrolyte levels with Myo Relax by MYOXCIENCE Nutrition: http://bit.ly/2HgCPOs Save with code: Podcast Link to show notes: https://bit.ly/2WbPDzT  

The TWiM folk explore disruption of a Burkholderia intracellular niche by a cell death program, and an increase in Brucella infectiousness after intracellular passage. Become a patron of TWiM. Links for this episode: Disrupting intracellular niche (mBio) Intracellular passage increases infectiousness (Infect Immun) Type IV secretion systems (Front Micro) Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim@microbe.tv

Snippet - Discussion about the difference between the virulence and transmissibility of a virus? Listen to the full podcast here: @Spotify

Chronique politique américaine avec Loïc Tassé, politologue et chroniqueur au Journal de Montréal : Robert Redfield aurait reçu des menaces de mort. Des robots auraient tué de manière autonome des humains. Les lacs du monde perdent leur oxygène.  Pour de l'information concernant l'utilisation de vos données personnelles - https://omnystudio.com/policies/listener/fr

Ever since COVID-19 was declared a Public Health Emergency of International Concern (PHEIC) on January 30th, 2020 and subsequently declared a pandemic by the World Health Organization (WHO) on March 11th, 2020, a topic that quickly followed was the speed at which the virus was mutating. The reality is that mutations are a normal part of the life cycle in microorganisms and infectious agents such as viruses. Nonetheless, there is a lot of public concern and uncertainty about these mutations and the global impact they will have down the road. In this episode of the Public Health Insight, we introduce viruses as infectious agents, the concept of mutations, and how it impacts a virus’s ability to spread.References for Our Discussion World Health Organization: SARS-CoV2 VariantsScience Mag: Viral mutations may cause another ‘very very bad’ COVID-19 wave scientists warnVox: The Coronavirus is mutating. Now what?Podcast Co-HostsLeshawn Benedict, MPH, MSc, CAPM®William Wang, BA, MPHGordon Thane, BMSc, MPHSulaiman Alhalbouni, BMSc, MPHShare Your Thoughts With Us!Follow us on Instagram, Twitter, LinkedIn, and Facebook. We would love it if you shared your thoughts by commenting on our posts, sending us a direct message through social media, or by emailing us at ThePublicHealthInsight@gmail.com. Until then, we’ll see you in the next one.Support Our ShowIf you like our show, feel free to lend us some support by making a contribution on our Patreon page (link below) so we can continue creating the content that you enjoy as we expand the Public Health Insight Community.Music CreditsTokyo Music Walker - Way HomeLukrembo - SunsetSupport the show (https://www.patreon.com/publichealthinsight)

The severity of malarial disease is influenced by interactions between the parasite, the host and environmental factors. In her third talk, Mota explains how her lab used a mouse model to study the impact of host nutritional status on disease severity. When they compared infections in calorically restricted (CR) mice and freely fed mice, they found less reproduction of the malaria parasite and a lower parasite load in CR mice.  This suggested that Plasmodium are able to sense and respond to host nutritional status.  Mota describes how her lab identified a key Plasmodium kinase, KIN, that seems to regulate parasite response to nutrient availability and may provide a target for antimalarial drugs.

The severity of malarial disease is influenced by interactions between the parasite, the host and environmental factors. In her third talk, Mota explains how her lab used a mouse model to study the impact of host nutritional status on disease severity. When they compared infections in calorically restricted (CR) mice and freely fed mice, they found less reproduction of the malaria parasite and a lower parasite load in CR mice.  This suggested that Plasmodium are able to sense and respond to host nutritional status.  Mota describes how her lab identified a key Plasmodium kinase, KIN, that seems to regulate parasite response to nutrient availability and may provide a target for antimalarial drugs.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.13.337667v1?rss=1 Authors: Bao, Y., Zhang, Q., Wang, L., Aguilera, J., Vazquez Reyes, S., Sun, J. Abstract: EsxA has been recognized as an important virulence factor of Mycobacterium tuberculosis (Mtb) that plays an essential role in Mtb cytosolic translocation by penetrating phagosomal membranes with its acidic pH-dependent membrane permeabilizing activity (MPA). Currently, the reported cytolytic activity of EsxA at neutral pH is controversial. In this study we have obtained direct evidence that it is the ASB-14, a detergent used in EsxA purification, but not EsxA that causes cytolysis at neutral pH. We have also found that the exogenously added EsxA was internalized into lung epithelial cells (WI-26) and inserted into the host membranes, and these processes could be blocked by cytochalasin D and bafilomycin A. This indicates that EsxA is bound by host surface receptors and internalized into acidic endosomal compartments. This observation has intrigued us to investigate the role of EsxA in mycobacterial adherence and invasion in host cells. Interestingly, compared to the Mycobacterium marinum (Mm) wild type strain, the Mm strain with deletion of the esxBA operon (MmEsxA:B) had a lower adherence but a higher invasion in WI-26 cells. More interestingly, either inducible knockdown of EsxAB or removal of the bacterial surface-associated EsxAB by Tween-80 exhibited opposite results compared to gene knockout. Finally, the surface-associated EsxA is correlated to mycobacterial virulence. Together, the present study has shown for the first time that EsxA is internalized into the host cells and inserts into the host membranes, and mycobacterial surface-associated EsxAB plays an important role in mycobacterial adherence and invasion in host cells, which warrants further investigation. Copy rights belong to original authors. Visit the link for more info

Ashton Forbes works in healthcare IT and is the plaintiff in a lawsuit against Gavin Newsom regarding mask mandates and lockdown orders. He provides a uniquely qualified perspective on the dire situation we find ourselves in because of overreaching government policies. Enjoy! follow us on twitter @undoctrinated1 instagram undoctrinatedpodcast email us undoctrinatedpodcast@gmail.com here are the links mentioned in the show: https://www.youtube.com/watch?v=gGavpYNpEP8&t=2s https://www.researchgate.net/publication/343775235_Evaluation_of_the_virulence_of_SARS-CoV-2_in_France_from_all-cause_mortality_1946-2020 https://www.nytimes.com/2020/08/29/health/coronavirus-testing.html https://www.gofundme.com/f/nomasks

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.17.253484v1?rss=1 Authors: Oulas, A., Zanti, M., Tomazou, M., Zachariou, M., Minadakis, G., Bourdakou, M. M., Pavlidis, P., Spyrou, G. M. Abstract: This study aims to highlight SARS-COV-2 mutations which are associated with increased or decreased viral virulence. We utilize, genetic data from all strains available from GISAID and countries' regional information such as deaths and cases per million as well as covid-19-related public health austerity measure response times. Initial indications of selective advantage of specific mutations can be obtained from calculating their frequencies across viral strains. By applying modelling approaches, we provide additional information that is not evident from standard statistics or mutation frequencies alone. We therefore, propose a more precise way of selecting informative mutations. We highlight two interesting mutations found in genes N (P13L) and ORF3a (Q57H). The former appears to be significantly associated with decreased deaths and cases per million according to our models, while the latter shows an opposing association with decreased deaths and increased cases per million. Moreover, protein structure prediction tools show that the mutations infer conformational changes to the protein that significantly alter its structure when compared to the reference protein. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.31.230904v1?rss=1 Authors: Yin, R., Luo, Z., Zhuang, P., Lin, Z., Kwoh, C. K. Abstract: Motivation: Influenza viruses are persistently threatening public health, causing annual epidemics and sporadic pandemics. The evolution of influenza viruses remains to be the main obstacle in the effectiveness of antiviral treatments due to rapid mutations. Previous work has been investigated to reveal the determinants of virulence of the influenza A virus. To further facilitate flu surveillance, explicit detection of influenza virulence is crucial to protect public health from potential future pandemics. Results: In this paper, we propose a weighted ensemble convolutional neural network for the virulence prediction of influenza A viruses named VirPreNet that uses all 8 segments. Firstly, mouse lethal dose 50 is exerted to label the virulence of infections into two classes, namely avirulent and virulent. A numerical representation of amino acids named ProtVec is applied to the 8-segments in a distributed manner to encode the biological sequences. After splittings and embeddings of influenza strains, the ensemble convolutional neural network is constructed as the base model on the influenza dataset of each segment, which serves as the VirPreNet's main part. Followed by a linear layer, the initial predictive outcomes are integrated and assigned with different weights for the final prediction. The experimental results on the collected influenza dataset indicate that VirPreNet achieves state-of-the-art performance combining ProtVec with our proposed architecture. It outperforms baseline methods on the independent testing data. Moreover, our proposed model reveals the importance of PB2 and HA segments on the virulence prediction. We believe that our model may provide new insights into the investigation of influenza virulence. Copy rights belong to original authors. Visit the link for more info

We're returning to the Sci-Fi horror game ViewScream for this episode. An infection has turned most of the crew of the Imperial Hellhound into zombies that seem intent on destroying the ship. Now the remaining crew must work together to survive but some of them might be hiding dangerous secrets. Additional music from Introspective Spacewalk by Asher Fulero.

You're listening to the July episode of 3 Minute 3Rs.The papers behind the pod:1. Reproducibility of animal research in light of biological variation. Nature review Neuroscience https://www.nature.com/articles/s41583-020-0313-32. Inactivated rabies vaccines: Standardization of an in vitro assay for residual viable virus detection. Plos Neglected Tropical Diseases https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.00081423. A novel biosafety level 2 compliant tuberculosis infection model using a ΔleuDΔpanCD double auxotroph of Mycobacterium tuberculosis H37Rv and Galleria mellonella. Virulence https://doi.org/10.1080/21505594.2020.1781486Transcript: [NA3RsC] Reproducibility is a cornerstone of the scientific method. But unfortunately, it's considered to be quite poor for all research findings, and especially animal studies. Experts in animal biology, experimental design, and statistics argue that one major cause of poor reproducibility is inappropriate standardization in the face of biological variation. In nature, individual animals and humans vary greatly as a result of the interaction between their genes and the environment. So if studies standardize this natural variation too much, then they risk producing findings that are not reproducible outside of a very specific set of conditions. As a solution, experts recommend that researchers should deliberately diversify their study subjects such as by varying sex, genotype, age, and environmental conditions. This does not necessarily need to increase sample size or cost. And ultimately, this diversification can reduce long-term research costs, increase efficiency, and reduce overall animal suffering. To learn more, go online to read the full paper in Nature Perspectives. [NC3Rs] Vaccines are a vital tool in the fight against disease. This includes neglected tropical diseases such as rabies, which kills around 60,000 people each year, mainly in Africa and Asia.When inactivated rabies vaccines are produced, they go through many stages of quality control, including testing for any remaining live virus. This process traditionally uses a lot of animals, but a recent paper by Beatriz Lourenço Moreira and colleagues explores an alternative in vitro assay that could replace some of this animal useThe new method combines two in vitro techniques to create an assay that's three times more sensitive than in vivo testing and five times quicker than other in vitro assays. What's more, it could replace the use of animals in residual live virus detection, decreasing animal use in quality control by two thirds overall.While further validation is needed, and regulatory challenges still exist, this study shows what the 3Rs have to offer in vaccine development. Read the paper now in PLoS Neglected Tropical Diseases.[LA]... See acast.com/privacy for privacy and opt-out information.

Una de las preguntas que más ha rondado por las bocas y pantallas de todos nosotros es ¿de dónde salió este virus? Ha habido respuestas absurdas, falsas, alarmistas, malintencionadas, pero también ha habido mucho trabajo científico que nos ha ayudado a despejar esta duda. En colaboración con La Pandemia de la Desinformación, un proyecto colectivo y multidisciplinario de divulgación para combatir la información errónea en estos tiempos, les traemos este episodio especial en el que abordamos algunas de los puntos más acuciantes sobre esa gran duda. Menú 00:00 - Aperitivo 01:23 - Saludos y presentaciones: 04:50 - I: Zoonosis 11:52 - II: Evidencias del origen natural 19:06 - III: Mutaciones y cepas 21:22 - IV: ¿Qué ganamos al saber del origen? 23:20 - Reflexiones finales y saludos Voces: Alejandro Cisneros, Laura Díaz, Sofía Flores, Rodrigo Pacheco y Víctor Hernández Guión: Sofía Flores, Rodrigo Pacheco y Víctor Hernández Investigación de contenidos: Alejandro Cisneros Supervisión de contenido: Alejandro Cisneros y Laura Díaz Coordinación en La Pandemia: Cindel Vergara Producción: Sofía Flores, Rodrigo Pacheco y Víctor Hernández Edición y diseñoo de audio: Víctor Hernández Voz en la rúbrica: Valeria Sánchez Este podcast es producido desde un lugar de la Ciudad de México donde hay muchos mercados, pero muy pocos pangolines (y donde se sigue intentando crear el modelo perfecto del virus con bloques de construcción). Fuentes y lecturas recomendadas Fuentes académicas: Andersen, K. G., Rambaut, A., Lipkin, W. I., Holmes, E. C., & Garry, R. F. (2020). The proximal origin of SARS-CoV-2. Cárdenas-Gonzáles, M., & Álvarez-Buylla, E. R. (2020). The COVID-19 Pandemic and Paradigm Change in Global Scientific Research. Holmes, E. C. (2009). The Evolution and Emergence of RNA Viruses. Holmes, E. C. (2013). What can we predict about viral evolution and emergence? Lancaster, L. Z., & Pfeiffer, J. K. (2012). Viral population dynamics and virulence thresholds. Flint, J., Racaniello, V. R., Rall, G. F., Skalka, A. M., & Enquist, L. W. (2015). Weiss, R. A. (2002). Virulence and pathogenesis. Woolhouse, M., Scott, F., Hudson, Z., Howey, R., & Chase-Topping, M. (2012). Human viruses: discovery and emergence. Notas periodísticas y otros textos: https://www.bbc.com/news/world-us-canada-52496098 https://theconversation.com/el-origen-del-coronavirus-sars-cov-2-a-la-luz-de-la-evolucion-136897 https://elpais.com/elpais/2020/05/09/ciencia/1589059080_203445.html https://www.estornuda.me/post/como-sabemos-que-el-coronavirus-sars-cov-2-tiene-un-origen-natural https://avanceyperspectiva.cinvestav.mx/tiene-el-coronavirus-sars-cov-2-un-origen-natural-revisita/?fbclid=IwAR0jtDbA-PmYuEKtAcF8ohy98nKZCMgeGFp3KjRTRO7fnHi8kQnqnUDeZHU https://www.nytimes.com/es/interactive/2020/04/30/science/coronavirus-mutacion.html https://www.virology.ws/2020/05/07/there-is-one-and-only-one-strain-of-sars-cov-2/ Música y audios Intro y salida: Little Lily Swing, de Tri-Tachyon, bajo licencia Creative Commons 3.0 de Atribución. Rúbrica: Now son, de Podington Bear, Bajo una licencia Creative Commons Internacional de Atribución No Comercial 3.0 Fondos: Hot Chip de Podington Bear, Vittoro by Blue Dot Sessions , Everything de Good Old Neon , Sneaker Chase de Podington Bear , Wonder de Podington Bear , Toboggan (Smooth Run) de Podington Bear , Twitterflated de Podington Bear, Saltimbanco de UP Paolo Pavan Pasqualino Ubaldini , The Bright Morning Star de Borrtex ; todos bajo licencia Atribución - No comercial Fragmento de "Te lo dije", de los Panchos, porque se nos advirtió. Fragmentos adicionales tomados de Youtube (pídannos la lista).

“In our challenge studies with a highly virulent European strain, the pigs had quite good protection from a vaccine that is new in Europe” In conversation with Dr. Andrea Ladinig (University of Veterinary Medicine Vienna, Austria) and Dr. Greg Stevenson (Iowa State University, USA) about investigations of genetics and vaccination to combat more virulent strains of the PRRS virus. Running time: 23 minutes

UC San Diego professor of biology Justin Meyer, who specializes in infectious disease research presents his course The Evolution of Infectious Diseases with special attention to the SARS-CoV-2 virus, the COVID-19 disease and its pandemic spread throughout the world. In this lecture - how SIR models can predict the spread and behavior of pathogens. Series: "The Evolution of Infectious Diseases with Justin Meyer" [Health and Medicine] [Science] [Show ID: 35830]

UC San Diego professor of biology Justin Meyer, who specializes in infectious disease research presents his course The Evolution of Infectious Diseases with special attention to the SARS-CoV-2 virus, the COVID-19 disease and its pandemic spread throughout the world. In this lecture - how SIR models can predict the spread and behavior of pathogens. Series: "The Evolution of Infectious Diseases with Justin Meyer" [Health and Medicine] [Science] [Show ID: 35830]

UC San Diego professor of biology Justin Meyer, who specializes in infectious disease research presents his course The Evolution of Infectious Diseases with special attention to the SARS-CoV-2 virus, the COVID-19 disease and its pandemic spread throughout the world. In this lecture - how SIR models can predict the spread and behavior of pathogens. Series: "The Evolution of Infectious Diseases with Justin Meyer" [Show ID: 35830]

UC San Diego professor of biology Justin Meyer, who specializes in infectious disease research presents his course The Evolution of Infectious Diseases with special attention to the SARS-CoV-2 virus, the COVID-19 disease and its pandemic spread throughout the world. In this lecture - how SIR models can predict the spread and behavior of pathogens. Series: "The Evolution of Infectious Diseases with Justin Meyer" [Show ID: 35830]

UC San Diego professor of biology Justin Meyer, who specializes in infectious disease research presents his course The Evolution of Infectious Diseases with special attention to the SARS-CoV-2 virus, the COVID-19 disease and its pandemic spread throughout the world. In this lecture - how SIR models can predict the spread and behavior of pathogens. Series: "The Evolution of Infectious Diseases with Justin Meyer" [Show ID: 35830]

UC San Diego professor of biology Justin Meyer, who specializes in infectious disease research presents his course The Evolution of Infectious Diseases with special attention to the SARS-CoV-2 virus, the COVID-19 disease and its pandemic spread throughout the world. In this lecture - how SIR models can predict the spread and behavior of pathogens. Series: "The Evolution of Infectious Diseases with Justin Meyer" [Show ID: 35830]

UC San Diego professor of biology Justin Meyer, who specializes in infectious disease research presents his course The Evolution of Infectious Diseases with special attention to the SARS-CoV-2 virus, the COVID-19 disease and its pandemic spread throughout the world. In this lecture - how SIR models can predict the spread and behavior of pathogens. Series: "The Evolution of Infectious Diseases with Justin Meyer" [Show ID: 35830]

UC San Diego professor of biology Justin Meyer, who specializes in infectious disease research presents his course The Evolution of Infectious Diseases with special attention to the SARS-CoV-2 virus, the COVID-19 disease and its pandemic spread throughout the world. In this lecture - how SIR models can predict the spread and behavior of pathogens. Series: "The Evolution of Infectious Diseases with Justin Meyer" [Show ID: 35830]

UC San Diego professor of biology Justin Meyer, who specializes in infectious disease research presents his course The Evolution of Infectious Diseases with special attention to the SARS-CoV-2 virus, the COVID-19 disease and its pandemic spread throughout the world. In this lecture - how SIR models can predict the spread and behavior of pathogens. Series: "The Evolution of Infectious Diseases with Justin Meyer" [Show ID: 35830]

UC San Diego professor of biology Justin Meyer, who specializes in infectious disease research presents his course The Evolution of Infectious Diseases with special attention to the SARS-CoV-2 virus, the COVID-19 disease and its pandemic spread throughout the world. In this lecture - how SIR models can predict the spread and behavior of pathogens. Series: "The Evolution of Infectious Diseases with Justin Meyer" [Show ID: 35830]

In this episode, Craig speaks with independent researcher, writer, and fellow podcaster Kerry Baldwin to discuss her article The Virulence of Moral Panic, published by the Libertarian Christain Institute. The conversation centers on how the 2020 Coronavirus pandemic can be understood as Moral Panic, a term borrowed from criminal psychology, that sheds light on the factors that push societies to act in certain ways. To learn more about Kerry Baldwin and for full show notes please visit: https://www.thebadroman.com/show-notes/episode-2

Filmed live at ASM Biodefense 2016 with special guests: Rebekah Kading and Wyndham Lathem. From the ASM Biodefense and Emerging Diseases Research meeting, Vincent Racaniello speaks with Rebekah and Wyndham about their work on Rift Valley Fever virus and other vector-borne pathogens, and the evolution and pathogenesis of Yersinia pestis, the agent of plague. Links for this episode  Rift Valley fever virus risk (Emerg Micr Inf) Predicting Rift Valley fever virus transmission (PLoS NTD) Culex in New York City (BioOne) Early emergence of Y. pestis (Nature Comm) Pneumonic plague (Trends Micro) Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Don't miss an episode of MicrobeWorld Video. Subscribe for free using iTunes or help support our work by purchasing the MicrobeWorld podcast application for iPhone and Android devices in the iTunes or Android app stores. Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim. Subscribe to TWiM (free) on iTunes, Stitcher, Android, RSS, or by email. You can also listen on your mobile device with the Microbeworld app.

Vincent meets up with Stan Maloy on the campus of San Diego State University to talk about his career in microbiology and his work as Dean of Science.