Podcast appearances and mentions of Roy J Carver

Guest Name and Bio: Dr. Charles Brenner Dr. Charles Brenner is the Roy J. Carver Chair and Head of Biochemistry at the University of Iowa, as well as a founding co-director of the University of Iowa Obesity Initiative. In 2004, Brenner, then a faculty member at Dartmouth College, discovered nicotinamide riboside (NR) to be a vital precursor of nicotinamide adenine dinucleotide (NAD+), which is made available by nicotinamide riboside kinases (Nrks) that are conserved between yeast and humans. In 2007, Dr. Brenner’s lab discovered a second pathway by which NR is converted to NAD+ and showed that NR can extend the lifespan of yeast cells by virtue of elevating NAD+ levels and increasing the activity of the NAD+-dependent Sir2 enzyme. In the past decade, Dr. Brenner has made multiple seminal contributions to NAD+ metabolism, which include engineering a yeast strain to convert inexpensive NAD+ precursor vitamins into NR, solving the crystal structure of human Nrk1, developing the methods for quantitative NAD+ metabolomics, and demonstrating the activity of oral NR in animal models of fatty liver disease; obesity; type 2 diabetes; diabetic and chemotherapeutic neuropathy; heart failure; and central brain injury. Dr. Brenner also led the first clinical trial of NR, which established safe oral availability in humans. He is currently focusing on the maternal and neonatal effects of oral NR and translating animal discoveries into evidence-based safe, human clinical practice for human conditions of metabolic stress. What you will learn from this episode: 1) What is the difference between NR (nicotinamide ribosise) and NAD+ (nicotinamide adenine dinucleotide) 2) What role does NAD+ have in aging and metabolic dysfunction 3) How could NAD+ potentially help in the setting of COVID-19 (Coronavirus) 4) What is the best way to increase your levels of NAD+ 5) How can NAD+ help with fatty liver and obesity How to learn more about our guest: Twitter: CharlesMBrenner https://brenner.lab.uiowa.edu/ https://twitter.com/charlesmbrenner Please enjoy, share, rate and review our podcast and help us bring the message about precision health care to the world!

Dr. Charles Brenner, Chief Scientific Advisor at ChromaDex, and the Roy J. Carver Chair & Head of Biochemistry at the University of Iowa discusses a landmark first-of-a-kind preclinical study on lactating and breastfeeding mothers that received a supplement of NR, nicotinamide riboside (Niagen) a unique B3 vitamin. Visit www.hpr.fm to listen to more interviews about healthcare and research findings.

Our guest today is Dr. Charles Brenner, the Roy J. Carver Chair of Biochemistry at the University of Iowa. Charles is one of the world’s leading experts on nicotinamide adenine dinucleotide, commonly referred to as NAD, which is an essential molecule found in every living cell.  In 2004, he discovered the nicotinamide riboside kinase pathway, which leads to a special form of vitamin B3. We talk to Charles about his research into NAD and why he believes supplementation with NR could help people age better. In addition to his work at the University of Iowa, he is also the chief scientific advisor for ChromaDex, which markets the NR supplement Tru Niagen. Toward the end of our interview, Charles talks about dozens of exciting new papers and studies that are on the horizon. One of those papers - Maternal Nicotinamide Riboside Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring- was published in Cell Reports on the same day as our interview with Charles went live. Also in today’s interview, we discuss: [00:06:29] How Charles became the first cancer biology graduate student in the biology department at Stanford University. [00:07:51] Charles’ research into nicotinamide adenine dinucleotide (NAD) during his time on the faculty at Thomas Jefferson University. [00:09:15] Charles’ discovery that nicotinamide riboside (NR) is a precursor of NAD. [00:19:47] Why Charles doesn’t use the term “anti-aging.” [00:25:52] The importance of nicotinamide adenine dinucleotide phosphate (NADPH) and its role as the central regulator of reactive oxygen species toxicity. [00:34:56] The circadian rhythms of NAD and the potential benefit of diurnal dosing. [00:38:45] Why skeletal muscle is one of the most sensitive target tissues for the anti-aging effects of NMN. [00:45:42] How the benefits of a ketogenic diet, intermittent fasting, time restricted eating could be related to NAD. [00:47:02] A recent human trial conducted by the University of Colorado that found Niagen increased NAD+ by 60 percent in healthy middle-aged and older adults after just six weeks. [00:49:19] The optimal dose of NR for humans. Show notes: [00:03:06] Charles talks about growing up as a kid who dreamed about becoming either a comedian or rabbi. [00:03:26] Charles describes his success on the math team in high school and how he also enjoyed playing tennis and running cross-country. [00:03:43] Charles reflects on his decision to attend Wesleyan University. [00:04:09] Although Charles decided to major in ecology, he found out upon arriving at Wesleyan that they did not have an ecology department. [00:05:05] Dawn mentions that after graduating with honors in biology, Charles traveled across the country to work in the Bay Area. She asks him what he did. [00:06:29] Charles talks about when and why he became interested in cancer research, and how he was the first cancer biology graduate student in the biology department at Stanford University. [00:07:51] Dawn asks about the work Charles did from 1996 to 2003 on nicotinamide adenine dinucleotide (NAD) during his time on the faculty at Thomas Jefferson University. [00:09:15] Ken brings up Charles’ research at Dartmouth, asking about his discovery that nicotinamide riboside (NR) is a precursor of NAD. [00:12:35] NAD is a coenzyme found in all living cells. It serves both as a critical coenzyme for enzymes that fuel reduction-oxidation reactions, carrying electrons from one reaction to another, and as a co-substrate for other enzymes.  Charles gives an overview of the research into NAD and its relationship to overall health and age-related diseases. [00:19:47] Dawn asks Charles why he doesn’t use the term “anti-aging.” [00:20:54] Charles discusses how Verdin and numerous other investigators have reported that NADcontent declines with age in multiple organs, such as pancreas, adipose tissue, skeletal muscle,

It's no secret that I inject myself with nicotinamide adenine dinucleotide (NAD). It's a bit spendy and a bit uncomfortable, but I do it. Nonetheless, some claim it's not necessary and that one can get all the NAD they need from supplementation. One such supplement that seems to be the current darling of the anti-aging industry is nicotinamide riboside (NR), and find out a bit more about it, I managed to get the discoverer of this "vitamin" on the show. His name is Dr. Charles Brenner. Dr. Brenner is the discoverer of nicotinamide riboside (NR) as a vitamin and a leading expert on NAD, which he calls "the central regulator of metabolism". Originally from Boston, he is a 1983 graduate of Wesleyan University, who worked in biotech for 5 years before conducting his PhD research in Cancer Biology in the Biochemistry Department of Stanford University. He subsequently performed his post-doctoral fellowship at Brandeis University before launching his independent career at Thomas Jefferson University. He moved to Dartmouth College in 2003, where he made the seminal discovery of the NR kinase pathway to NAD, and he was recruited to the University of Iowa in 2009 as the Roy J. Carver Chair and Head of Biochemistry. Dr. Brenner has been funded by the Leukemia & Lymphoma Society, the March of Dimes, the Beckman Foundation, the Burroughs Wellcome Trust, the Lung Cancer Research Foundation, the Roy J. Carver Trust, the National Science Foundation and the National Institutes of Health, and has won a number of awards for his research and contributions to innovative education. For example, thanks to technologies that Dr. Brenner developed, it is now possible to determine how any disease or condition interacts the NAD metabolome, which is the set of genes and small molecules that comprise the NAD ecosystem. Dr. Brenner is a founding member of the ChromaDex Scientific Advisory Board and serves as their Chief Scientific Advisor. Since conducting the first clinical trial of nicotinamide riboside in healthy adults, he has continued to conduct research on mechanisms by which NR boosts metabolism and protects against diseases and conditions of metabolic stress in animals and to participate in the safe and evidence-based clinical development of NR. During our discussion, you'll discover: -How Dr. Brenner enhances his own longevity and anti-aging protocol...8:45 -Why it's best to take NR supplements twice per day...11:00 -The seven specific ways that NAD can get damaged...17:30 -How you can test your own levels of NAD...32:30 -How Dr. Brenner discovered NR as a unique, new vitamin...37:15 -Why niacin in different than NR, and why niacin is not a good way to boost NAD...42:30 -The diseases and conditions that benefit from boosting NAD...48:00 -The connection between NAD, longevity and anti-aging...53:30 -Specific foods that you can eat to increase your NAD availability...1:03:15 -Dr. Brenner's opinion on intravenous NAD and injectable NAD...1:10:15 -Whether TruNiagen is different than any other forms of NR...1:19:30 -And much more! Episode Sponsors -  Get $60 in free groceries + free shipping when you order using my special link! - Did you know that only 3% of coffee brands are certified organic? Count Kion Coffee among that elite group, and it tastes amazing too! - Get 30% off your order using promo code “ben” and get an additional 10% off any subscription order. - Use promo code “greenfield” and receive 20% off your order. Resources from this episode: - - - - -. -A portion of Tom Ingoglia of the reply to me was as follows: "There is a that shows it (NAD) is crossing in fibroblasts. I want to say that it is connexin 43. There is a membrane channel for NMN too...NR has been around for 5 years. NAD IV has been around for 50..." Do you have questions, thoughts or feedback for Dr. Brenner or me, or about NAD or NR in general? Leave your comments below and one of us will reply!

There has been a lot of buzz recently surrounding a new supplement that could boost our energy levels as we grow old. It is a recently discovered form of vitamin B3 and has been widely touted as a possible tool to enhance the aging process. We are going to take a deep dive into what it is and how it works. Nicotinamide riboside (NR) is converted by the body into nicotinamide adenine dinucleotide (NAD) which is an essential molecule found in every living cell and plays a significant role in energy production, regulation of the circadian rhythm and cognitive function. Dr. Charles Brenner is one of the world’s leading authorities on the biochemistry behind NR and its potential to extend life in some organisms. Dr. Brenner is the Roy J. Carver Chair and Head of Biochemistry at the University of Iowa and founding co-director of the University of Iowa Obesity Initiative. He is also chief scientific adviser to Chromadex, a California-based company behind the NR supplement, Tru Niagen. In this in-depth interview, Dr Brenner explains the significance of NAD and why he believes supplementation with NR could help us "age better." He also elaborates on why he refuses to describe NR as “miraculous or magic” and explains why he is uncomfortable with the often-heard expression, 'anti-aging,’ in the marketing of human longevity.