Podcasts about Cell Reports

Sachin Patel, MD, PhD, is the chair and Lizzie Gilman Professor of Psychiatry and Behavioral Sciences at Feinberg and diretor of the Stephen M. Stahl Center for Psychiatric Neuroscience. In this episode, he talks about the current mental health crisis in this country, his research and vision for the department. Since this episode was originally released, Patel has published findings in the journal, Cell Reports, which uncovered new insights into the synaptic connections of subgroups of interneurons. These findings may improve the understanding of fear responses and could inform new targeted therapies for post-traumatic stress disorder.

Exploramos o fascinante cruzamento entre microbiologia e astrobiologia: como os menores organismos da Terra podem nos ajudar a entender a vida fora dela. Discutimos os extremófilos, organismos que vivem em condições extremas, os experimentos da NASA com microrganismos no espaço e como a microbiota humana muda em astronautas durante missões espaciais. Fechamos com uma viagem pela cultura pop, onde micróbios alienígenas são tanto vilões como metáforas da própria humanidade. Patronato do SciCast: 1. Patreon SciCast 2. Apoia.se/Scicast 3. Nos ajude via Pix também, chave: contato@scicast.com.br ou acesse o QRcode: Sua pequena contribuição ajuda o Portal Deviante a continuar divulgando Ciência! O SciCast passou pra segunda fase do Prêmio MPB - Melhores Podcasts do Brasil 2025 Votem em nós e nos nossos parceirosCiências: SciCastFicção e Fantasia: RPGuaxaCultura Pop: MiçangasCultura e Literatura: Perdidos na EstanteDiversidade e Inclusão: Tribo TDAHHumor: Podago https://www.premiompb.com.br/votar Contatos: contato@scicast.com.br https://twitter.com/scicastpodcast https://www.facebook.com/scicastpodcast https://www.instagram.com/PortalDeviante/ Fale conosco! E não esqueça de deixar o seu comentário na postagem desse episódio! Expediente: Produção Geral: Tarik Fernandes e André Trapani Equipe de Gravação: Túlio Monegatto Tonheiro, Marcelo de Matos, Crhisllane Vasconcelos, Rita Kujawski, Mirele Fernandes, Naelton de Araújo Citação ABNT: Scicast #666: Astrobiologia: microrganismos extremófilos e aliens. Locução: Túlio Monegatto Tonheiro, Marcelo de Matos, Crhisllane Vasconcelos, Rita Kujawski, Mirele Fernandes, Naelton de Araújo. [S.l.] Portal Deviante, 20/10/2025. Podcast. Disponível em: https://www.deviante.com.br/podcasts/scicast-666 Imagem de capa: Aerial image of Grand Prismatic Spring in Yellowstone National Park (view from the south) Expotea: https://expotea.com.br/https://www.instagram.com/expoteabrasil/ Referências e Indicações NASA Astrobiology Strategy. 2015. Disponível em: https://astrobiology.nasa.gov/ COLD scale Call for a framework for reporting evidence for life beyond Earth | Nature Survival of microorganisms during two-year exposure in outer space near the ISS | Scientific Reports Garrett-Bakelman FE et al. The NASA Twins Study. Science. 2019. Rothschild LJ & Mancinelli RL. Life in extreme environments. Nature Reviews Microbiology. 2001. Horneck G et al. Resistance of bacterial spores to outer space. Microbiol Mol Biol Rev. Schulze-Makuch D, Irwin LN. Life in the Universe. Springer, 2018. Voorhies AA et al. Study of the impact of long-duration spaceflight on the human microbiome. Cell Reports, 2019.ESA Life in Space: https://www.esa.int/Science_Exploration/Human_and_Robotic_Exploration/Research/Life_in_space Sugestões de literatura: Project Hail Mary - Andy Weir O Enigma de Andrômeda See omnystudio.com/listener for privacy information.

We're resharing an episode from October 2022. How are habits – both good and bad – formed in the brain, and what role do habits play in diseases of the brain? These are some of the questions neuroscientist, Talia Lerner, PhD, is investigating in her lab. Her recent study, published in Cell Reports, may change the overall understanding of how habits are formed and could be broken.    Since this episode was first recorded in fall 2022, Lerner's team has published new research looking at sex differences. In a paper in Neuropsychopharmacology, her team discovered how novel sex-specific mechanisms control how stress hormones impact dopamine transmission and motivation. 

Mutant super-powers give Korean sea women diving abilitiesThe Haenyeo, or sea women, of the Korean island of Jeju have been celebrated historically for their remarkable diving abilities. For hour after hour they dive in frigid waters harvesting sea-life, through pregnancy and into old age. A new study has shown they are able to do this because of specific genetic adaptations that appeared in their ancestors more than a thousand years ago. These genes make them more tolerant to the cold, and decrease diastolic blood pressure. The women also spend a lifetime training, beginning to dive at age 15 and continuing on until their 80s or even 90s. Melissa Ilardo of Utah University and her team published their findings in the journal Cell Reports.This dessert is automatic and autonomous Care for a slice of robo-cake? Scientists in Europe have baked up a cake with pneumatically powered animated gummy bears, and candles lit by chocolate batteries. They think their edible robotics could develop in the future to food that could bring itself to the hungry and medicine could deliver itself to the sick. Mario Caironi of the Italian Institute of Technology and his colleagues presented their creation at Expo 2025 Osaka.Shrinking Nemo — heat is causing clownfish to downsizeScientists have found that clownfish, made famous by the Disney movie Finding Nemo, have an ability never seen before in fish in the coral reefs. When the water they live in gets warmer, they are able to shrink their bodies — becoming a few per cent of their body length shorter — to cope with the stress of the heat. Melissa Versteeg of Newcastle University says the size of the clown anemonefish is important for their survival and their ranking within their hierarchical society. The research was published in the journal Science Advances.When the music moves you — the brain science of grooveYou know that groove feeling you get when you listen to certain music that compels you to shake your bootie? Scientists in France investigated how our brains experience groovy music to better understand how we anticipate rhythms in time. They discovered that we perceive time in the motor region that controls movement. Benjamin Morillion from Aix Marseille Université said they also found a specific rhythm in the brain that helps us process information in time, that could predict if a person thought the music was groovy. The study was published in the journal Science Advances.Scientists hope a new storm lab will help us understand destructive weatherExtreme weather is far less predictable than it used to be, and now a new research centre at Western University wants to transform our understanding of Canada's unique weather systems. The Canadian Severe Storms Laboratory will collect nation-wide data on extreme weather, including hailstorms, tornadoes, and flash flooding, and look for patterns to help predict where they'll be hitting and how to prevent the most damage. Producer Amanda Buckiewicz spoke with:Greg Kopp, ImpactWX Chair in Severe Storms Engineering and CSSL founding director at Western UniversityHarold Brooks, senior research scientist at NOAA's National Severe Storms LaboratoryJohn Allen, associate professor of meteorology at Central Michigan UniversityPaul Kovacs, executive director of the Institute for Catastrophic Loss Reduction at Western University.Tanya Brown-Giammanco, director of Disaster and Failure Studies at NIST

Die Themen in den Wissensnachrichten: +++ Mehr Korallenriffe weltweit durch Bleiche bedroht +++ Beziehung zu Hunden wie zu bestem Freund oder eigenem Kind +++ Beschäftigte in Deutschland gestresst und nicht besonders zufrieden im Job +++**********Weiterführende Quellen zu dieser Folge:84% of the world's coral reefs impacted in the most intense global coral bleaching event ever, ICRI, 23.04.2025Similarities and differences between dog–human and human–human relationships, Scientific Reports, 22.04.2025State of the Global Workplace, Gallup, abgerufen am 23.04.2025Neural correlates of device-based sleep characteristics in adolescents, Cell Reports, 16.04.2025Good News: Erfolgreiche Schneeleoparden-Zählungen in Nepal und Indien, WWF, 23.02.2025Alle Quellen findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: TikTok und Instagram .

Le piastrine, che svolgono un ruolo importante nella coagulazione del sangue, giocherebbero un ruolo chiave anche nella comunicazione cervello-corpo. Questo è quanto sottolinea uno studio pubblicato su Cell Reports che commentiamo a Obiettivo Salute con la prof.ssa Cristina Limatola del Dipartimento di Fisiologia e Farmacologia dell'università Sapienza di Roma, che ha coordinato la ricerca.

Step into the future of primary care with Artificial Intelligence and Machine Learning (AI/ML). In this episode, you'll discover how these transformative technologies are revolutionizing healthcare as three expert voices from STFM's cutting-edge Artificial Intelligence and Machine Learning for Primary Care Curriculum reveal insider strategies to slash administrative burden—and maybe even carve out time for your dream vacation. Whether you're an educator eager to innovate, or a clinician ready to lead your team in implementing new tools, this dynamic panel delivers practical tips, ethical insights, and the inspiration you need to confidently participate in the AI revolution.Our Panelists:Cornelius James, MDJaky Kueper, PhDWinston Liaw, MD, MPHHosted by Omari A. Hodge, MD, FAAFP and Jay-Sheree Allen Akambase, MDCopyright © Society of Teachers of Family Medicine, 2025Resources:Artificial Intelligence and Machine Learning for Primary Care Curriculum (AiM-PC)Upcoming Opportunity - Ethical Use of AI in the Family Medicine Clinic - STFM Webinar scheduled for May 30, 2025 at 12pm CTArtificial Intelligence and Family Medicine: Better Together - Fam Med Generative Artificial Intelligence and Large Language Models in Primary Care Medical Education - Fam Med Artificial Intelligence-Prompted Explanations of Common Primary Care Diagnoses - PRiMER Guest Bio:Cornelius James, MDDr. James is an Assistant Professor in the Departments of Internal Medicine, Pediatrics and Learning Health Sciences at the University of Michigan (U-M). He is a general internist and a general pediatrician practicing as a primary care physician. He holds the James O. Woolliscroft, MD Endowment in Humane Patient Care.Dr. James has served in many educational roles across the continuum of medical education, including serving as the director of the University of Michigan Medical School evidence-based medicine curriculum, and an Associate Program Director for the U-M Internal Medicine Residency Program. He also serves on local and national committees, including the U-M Clinical Intelligence Committee and the International Advisory Committee for Artificial Intelligence. In multiple years Dr. James has been identified as one of the top teachers in the Department of Internal Medicine. In addition, in 2022 he received the Kaiser Permanente Excellence in Teaching award, the most prestigious teaching award given by the U-M medical school. Dr. James has completed the American Medical Association (AMA) Health Systems Science Scholars program, and he was also one of ten inaugural 2021 National Academy of Medicine Scholars in Diagnostic Excellence. His research interests include augmenting clinical reasoning with artificial intelligence, and equitable implementation of safe and effective digital health tools into clinical practice.His work has been published in JAMA, Annals of Internal Medicine, Academic Medicine, the Journal of General Internal Medicine, Cell Reports, and more. Jaky Kueper, PhDJaky Kueper, PhD, is an epidemiologist and computer scientist with the Scripps Research Digital Trials Center. Her work in AI for primary care ranges from investigating primary care AI needs and priorities to co-developing AI solutions with Community Health Centres. She's also been engaged in several AI for heal

References Discov. Immunol. 2024 Nov 19;3(1):kyae016. Cell Reports 2015. 13, Issue 1p132-144October 06. Guerra, DJ. 2025. Biochemistry Lecture Notes, unpublished Rachmaninoff, S. 1900. Piano Concerto 2 in C minor. op.18.Khatia. https://www.youtube.com/watch?v=tSvq_GnGfTI&t=761s Kirwan, Danny 1971. "Woman of a Thousand Years" on Future Games lp. https://youtu.be/DQYHFWGXeDk?si=sYVGCrCvilagi5rt

In this special edition of the podcast, we will talk with the new Editor-in-Chief Janet Rossant and hear about her vision for the journal, its promising future, and what she sees as some of the exciting prospects over the horizon for stem cell research. We will also talk with Yvonne Fisher, the journal's Managing Editor, and Jack Mosher of the ISSCR, about the evolution of the journal and its role in the Society. GuestsJanet Rossant is the new Editor-in-Chief of Stem Cell Reports. She holds an appointment as the Chief of Research Emeritus and Senior Scientist at The Hospital for Sick Children and is the President and Scientific Director of the Gairdner Foundation. Widely recognized as an expert in embryonic development, Professor Rossant has been recognized for her contributions to science with awards, including the Ross G. Harrison Medal (lifetime achievement award) from the International Society of Developmental Biologists, the March of Dimes Prize in Developmental Biology, the Conklin Medal from the Society for Developmental Biology, and the 2018 L'Oréal For Women in Science Award. She is a Fellow of the Royal Societies of both London and Canada, and an International member of the US National Academy of Sciences. She previously served as President of the ISSCR. Learn more about Stem Cell Reports editorial team. Yvonne Fisher is the Managing Editor of Stem Cell Reports. Yvonne received her PhD from Frankfurt University and did her postdoctoral work in the laboratory of Henrik Semb at the University of Lund in Sweden. Yvonne is the longest serving member of the journal, serving as Managing Editor since the journal's inception in 2012. Jack Mosher is the Scientific Advisor for the International Society for Stem Cell Research. He received his PhD from the University of North Carolina in Chapel Hill and was a postdoctoral fellow in the laboratory of Sean Morrison at the University of Michigan. Jack serves numerous roles for the Society including administrative oversight of Stem Cell Reports.  HostMartin Pera, Editor-in-Chief, Stem Cell Reports and The Jackson LaboratoryX: @martinperaJAXAbout Stem Cell ReportsStem Cell Reports is the open access, peer-reviewed journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.X: @StemCellReportsAbout ISSCRWith nearly 5,000 members from more than 80 countries, the International Society for Stem Cell Research (@ISSCR) is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.ISSCR StaffKeith Alm, Chief Executive OfficerYvonne Fisher, Managing Editor, Stem Cell ReportsKym Kilbourne, Director of Media and Strategic CommunicationsMegan Koch, Marketing ManagerJack Mosher, Scientific AdvisorHunter Reed, Senior Marketing CoordinatorVoice WorkBen Snitkoff

Die Themen in den Wissensnachrichten: +++ Wattenmeer ist im letzten halben Jahrhundert fast zwei Grad wärmer geworden +++ Olivenölpreise haben sich fast verdoppelt +++ Wie Mozart, Beethoven und Co bei Depressionen helfen können +++**********Weiterführende Quellen zu dieser Folge:Climate change impacts on a sedimentary coast—a regional synthesis from genes to ecosystems/ Marine Biodiversity, 01.08.2024Verbraucherpreisindizes, Auffällige Preisveränderungen im Juli 2024/ Destatis, 09.08.2024Auditory entrainment coordinates cortical-BNST-NAc triple time locking to alleviate the depressive disorder/ Cell Reports, 09.08.2024World's biggest iceberg spins in ocean trap/ BBC, 04.08.2024A Statistical Study of Space Hurricanes in the Southern Hemisphere/ JGR Space Physics, 25.06.204Alle Quellen findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: Tiktok und Instagram.

Humans have long sought the fountain of youth, and recently scientists have explored the biological basis of aging and potential strategies to reverse the process. Along with groundbreaking discoveries that have enabled extending the lifespan of model organisms, the anti-aging movement has spurred an entire industry focused on stopping the biological clock. In today's episode of Beyond the Abstract, Derek and Dan discuss recent studies about the aging process and debate the promises and pitfalls of this fast-moving field.This episode is sponsored by Proteintech Group, a company that creates reagents for the biomedical sciences so scientists can conduct groundbreaking science. Visit them at www.ptglab.com to find out more.The information presented here is not medical advice. Consult your physician for any questions regarding your personal health.Articles DiscussedAbad et al. Reprogramming in vivo produces teratomas and iPS cells with totipotency features. Nature, 2013.Ross et al. Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity. Nature, 2024.Ocampo et al. In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. Cell, 2016.Wang et al. In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche. Nature Communications, 2021.Browder et al. In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice. Nature Aging, 2022.Weindruch et al. The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. Journal of Nutrition, 1986.Lu et al. Reprogramming to recover youthful epigenetic information and restore vision. Nature, 2020.Yucel and Gladyshev. The long and winding road of reprogramming-induced rejuvenation. Nature Communications, 2024.Lopez-Otin et al. The Hallmarks of Aging. Cell, 2013.Choudhury et al. Proline restores mitochondrial function and reverses aging hallmarks in senescent cells. Cell Reports, 2024.Zeng et al. Restoration of CPEB4 prevents muscle stem cell senescence during aging. Developmental Cell, 2023.

Formare ricordi di eventi simili costituisce una vera e propria sfida per il nostro cervello. È essenziale che ogni evento venga memorizzato in maniera separata per preservarne la specificità. Tuttavia, è altrettanto importante riconoscere e ricordare gli aspetti comuni tra gli eventi. Se questo delicato processo viene compromesso, le persone rischiano di confondere un evento con un altro, perdendo così la chiarezza e la specificità dei propri ricordi.Un nuovo studio pubblicato sulla rinomata rivista scientifica Cell Reports ha identificato un intricato processo cerebrale che consente di distinguere e memorizzare eventi simili in maniera separata, mantenendo al contempo le somiglianze tra di essi. Questa ricerca è stata condotta dalle ricercatrici Giulia Concina, Luisella Milano e Annamaria Renna coordinate dal Prof. Benedetto Sacchetti del Dipartimento di Neuroscienze dell’Università di Torino, ospite di Nicoletta Carbone a Obiettivo Salute.

An estimated 32,000 Americans are currently living with ALS, or amyotrophic lateral sclerosis, a progressive neurodegenerative disease that attacks motor neurons in the brain and spinal cord. Northwestern investigators have uncovered novel cellular mechanisms involved in two types of genetic ALS that might lead to future targeted therapies. Evangelos Kiskinis, PhD, shares insights on these findings recently published in Science Advances and Cell Reports. 

In this episode of the Epigenetics Podcast, we talked with Mitch Guttman from California Institute of Technology about his work on characterising the 3D interactions of the genome using Split-Pool Recognition of Interactions by Tag Extension (SPRITE). Mitch Guttman discusses his exploration of the long non-coding RNA Xist, which plays a crucial role in X chromosome inactivation. He explains how they discovered that Xist is present everywhere in the nucleus, not just in specific locations on the X chromosome. Through their research, they identified critical proteins like SHARP that are involved in X chromosome silencing. The discussion then shifts to SPRITE, a method they developed to map multi-way contacts and generalize beyond DNA to include RNA and proteins. They compare SPRITE to classical proximity ligation methods like Hi-C and discuss how cluster sizes in SPRITE can estimate 3D distances between molecules. The conversation also touches upon the potential of applying SPRITE to single-cell experiments, allowing for the mapping of higher order nucleic acid interactions and tracking the connectivity of DNA fragments in individual cells.   References Jesse M. Engreitz et al., The Xist lncRNA Exploits Three-Dimensional Genome Architecture to Spread Across the X Chromosome. Science 341,1237973(2013). DOI:10.1126/science.1237973 Chun-Kan Chen et al., Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing. Science 354, 468-472(2016). DOI: 10.1126/science.aae0047 Quinodoz, S. A., Ollikainen, N., Tabak, B., Palla, A., Schmidt, J. M., Detmar, E., Lai, M. M., Shishkin, A. A., Bhat, P., Takei, Y., Trinh, V., Aznauryan, E., Russell, P., Cheng, C., Jovanovic, M., Chow, A., Cai, L., McDonel, P., Garber, M., & Guttman, M. (2018). Higher-Order Inter-chromosomal Hubs Shape 3D Genome Organization in the Nucleus. Cell, 174(3), 744-757.e24. https://doi.org/10.1016/j.cell.2018.05.024 Goronzy, I. N., Quinodoz, S. A., Jachowicz, J. W., Ollikainen, N., Bhat, P., & Guttman, M. (2022). Simultaneous mapping of 3D structure and nascent RNAs argues against nuclear compartments that preclude transcription. Cell Reports, 41(9), 111730. https://doi.org/10.1016/j.celrep.2022.111730 Perez, A. A., Goronzy, I. N., Blanco, M. R., Guo, J. K., & Guttman, M. (2023). ChIP-DIP: A multiplexed method for mapping hundreds of proteins to DNA uncovers diverse regulatory elements controlling gene expression [Preprint]. Genomics. https://doi.org/10.1101/2023.12.14.571730   Related Episodes Epigenetics and X-Inactivation (Edith Heard) Hi-C and Three-Dimensional Genome Sequencing (Erez Lieberman Aiden) Unraveling Mechanisms of Chromosome Formation (Job Dekker)   Contact Epigenetics Podcast on X Epigenetics Podcast on Instagram Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Epigenetics Podcast on Threads Active Motif on X Active Motif on LinkedIn Email: podcast@activemotif.com

Alan Fredendall // #FitnessAthleteFriday // www.ptonice.com  In today's episode of the PT on ICE Daily Show, Fitness Athlete division leader Alan Fredendall discusses current recommendations on protein intake, new possible recommendations, and barriers to showing efficacy with different amounts of protein consumption. Take a listen to the episode or check out the show notes at www.ptonice.com/blog If you're looking to learn from our Clinical Management of the Fitness Athlete division, check out our live physical therapy courses or our online physical therapy courses. Check out our entire list of continuing education courses for physical therapy including our physical therapy certifications by checking out our website. Don't forget about all of our FREE eBooks, prebuilt workshops, free CEUs, and other physical therapy continuing education on our Resources tab. EPISODE TRANSCRIPTION ALAN FREDENDALL All right. Good morning. PT on Ice Daily Show. Happy Friday morning. Hope your morning is off to a great start. My name is Alan. Happy to be here today. Currently have the pleasure of serving as the Chief Operating Officer here at Ice and a faculty member in our Fitness Athlete Division. It is Friday. It is Fitness Athlete Friday. We talk all things related to CrossFit, Olympic weightlifting, powerlifting, endurance athletes, If you are working with a patient or client who is recreationally active, out on the road, on the bike, in the gym, Fitness Athlete Friday is for you. Just a quick announcement before we get into today's topic. If you're going to be at CSM or you're already at CSM, join us tomorrow morning, 5am, CrossFit Southie. We have a free workout going on, led by me. I'm getting on a plane later tonight to fly out there and run the workout tomorrow morning. So whether you have many years of CrossFit experience, whether you have zero minutes of CrossFit experience, we're going to have a fun workout tomorrow morning at five. Please go on our Instagram, go into the pin post and sign up for the sign up form. The link is in that pin post. So today, Fitness Athlete Friday, what are we talking about? We're talking about a paper that just came out at the end of 2023 and was published a few weeks ago, looking specifically at protein digestion. Hang on, buddy. Come here. Sorry about that. We're going to talk about protein digestion and the upper limits of what we think can happen with protein digestion. So we're going to talk about current protein recommendations based on the current body of research. We're going to talk about what this paper found and the conclusions it drew that may change those protein recommendations. And then we're going to talk about barriers to this research. CURRENT PROTEIN CONSUMPTION RECOMMENDATIONS So the paper we're referencing today, the title is the anabolic response to protein ingestion during recovery from exercise has no upper limit in magnitude and duration in humans. was a paper published in December 2023 by Tromelin and colleagues, pardon my sick son coughing, and the journal title is Cell Reports in Medicine. So that's the paper we're referencing. Current protein recommendations quite old and they typically recommend and advocate that humans can't digest or otherwise synthesize protein in amounts above about 20 to 25 grams of protein per hour and If you're like me, you were sitting in a lecture in undergrad maybe 20 years ago and you heard that based on literature from the 90s and the early 2000s and you thought, hmm, that seems really specific and also really impractical given how much protein we're recommending that people eat. How can somebody possibly only synthesize and utilize 20 to 25 grams per hour. That would mean an individual, especially a larger, more muscular individual, would basically need to be always eating protein, right? A lot of these studies look specifically at whey protein, a faster digesting version of protein. Whey protein is essentially the watery portion of milk with all the fat strained out. But even at moderate protein consumptions, think about an individual who's maybe 6'6", 300 pounds. No, no. No, no, okay, we're gonna hold you all the time. Somebody who's 6'6", 300 pounds, that person would need to eat 20 to 25 grams of protein for 12 to 14 hours in a row to get all of their daily protein in, maybe just at a maintenance protein level. That is really impractical and yet, up until this paper was published in 2023, we don't really have any other recommendations that we could give. So cue this paper being published at the end of the year. You see yourself, hi. NEW PROTEIN CONSUMPTION RECOMMENDATIONS This paper, fantastic methodology, amazing study, really good incorporation of inclusion and exclusion criteria of the subjects used, but also did a really good job of being very thorough in measuring and tracking the protein synthesis in the subjects in the study. So let's talk about that study. This study looked at 36 healthy males between 18 and 40. Inclusion criteria, they had to have a BMI between 18 and 30. They had to have already been exercising one to three days per week, so they needed to basically be familiar with exercise, particularly resistance training. And exclusion criteria included anybody who smoked, anybody who was lactose intolerant, and anybody who was taking any sort of prescription medication. So basically we looked at rather young, rather healthy men. What did we do? We had them all perform the same type of resistance exercise. We had them perform the same resistance exercise protocol. They went into the gym, they performed one set of 10 reps at 65% of their max on lat pulldown, leg press, leg extension, and also chest press, so bench press machine. They then did four sets to failure at 80% of their max. So they did all the same resistance training protocol. And then what changed, what varied in this study was how much protein they consumed after the resistance training protocol. So some subjects were given no protein, that was the control group. Some subjects were given 25 grams of protein. And then another group was given 100 grams of protein. So four times current best recommendations. And the hypothesis was, how much protein synthesis might we see compared to the 25 gram group in the 100 gram group. We looked at immediately post-exercise, we looked up to 12 hours post-exercise and we found some really interesting results that essentially the higher protein group saw continually increased levels of protein synthesis out to the end of the study, the end of the 12-hour period. So the 25-gram group had increased protein synthesis obviously compared to the zero-gram group, but the 100-gram group had 20% increased levels of protein synthesis in the zero to four-hour measurement window and 40% higher in the four to 12-hour post-exercise window. So this paper is great because it really opens up the notion that we can front load our protein and that we can potentially catch up on a protein deficit later in the day. For a lot of our folks, especially our active folks who are also maybe working, wrangling kids during the workday, trying to get enough protein in and trying to get it in those 25 gram feedings is probably just not feasible when we're looking at individuals eating 200, 250, maybe even 300 grams of protein a day. Simply not possible to get that. So a lot of those folks have issues with timing of protein intake. and also the belief that any consumption beyond 25 grams might be wasted. This article is really a landmark paper because it shows that that might not be the case, that we can front load large doses of protein or catch up with big doses of protein later in the day and see really long windows of protein synthesis after resistance training. Again, 40% higher at the 12-hour mark compared to 20% higher at the 4-hour mark tells us protein synthesis actually increased the further away we got from both the exercise and the actual consumption of that protein. RESEARCH BARRIERS Now there are some barriers with this research, we need to be mindful of what this paper does not say. This paper did not look at objective measurements of things like strength or hypertrophy, so it would not be fair, hi buddy, you're gonna knock my tripod over, It would not be fair to use this study to say that eating 100 grams of protein at a time makes you stronger, makes your muscles bigger because the study did not look at this and therefore we cannot conclude that 100 gram doses are better. What we can conclude is that this may be an alternative way to consume our protein that results in equal or even higher amounts protein than the traditional recommendations of 25 grams per hour. What we also need to be mindful of is that all of the research on 25 grams per hour looks specifically at subjects fasted eating whey protein. This study literally did the opposite. It looked at individuals who were fed, who had just performed resistance training, and who were essentially eating casein protein, the fatty portion of milk protein. So eating basically the opposite aspect of the protein and doing it under a different mechanism, doing it after exercise as compared to doing it fasted. So it is a little bit of comparing apples to oranges. Nonetheless, what we can take away from this paper is an alternative feeding strategy, especially for those individuals who we see in the clinic, who we see in the gym, who may tell us that they simply don't have time in their day, time in their schedule to eat protein in 25 gram feedings. If those patients, if those athletes, if those clients are already saying, hey, I know I'm not getting enough protein because I don't have time to eat 25 grams every hour for 14 hours, and I'm just simply not eating protein, then this is a very viable alternative solution of, hey, let's try front-loading your protein before you leave the house for the day. Let's try eating, you know, 50, 75, 100 grams of protein, maybe half, maybe 75% of our protein intake for the day before we leave the house. Now again, what we can't promise those people is that they will have equal or better levels of muscular strength or hypertrophy gains, but nonetheless we know how important protein is at least for recovery. so we can make that alternative recommendation to those patients and clients. SUMMARY So, protein, is 25 grams an hour the maximum? It doesn't appear so. It appears that the more we eat, the higher levels of synthesis that we have, at least in the scope of this paper, up to 12 hours after we've consumed that protein. Is it better? We don't know yet. We need more research. We need to now look at a study of folks eating 25 grams versus 100 grams and now measuring them more longitudinally and seeing what does muscular hypertrophy look like, what does muscular strength look like, even what does functional outcomes look like, different functional tests. but that being said this is still a very landmark foundational paper that should change our mind about how we think about eating protein that we can think about front loading if we need to we can think about catching up at the end of the day eating a big dose of protein maybe with dinner. I know Mitch Babcock who teaches here in the fitness athlete division a big fan of a big bowl of cereal with protein powder on it on the end of the day just to get a big lump of protein in before the day's end and that might be a viable successful alternative for a lot of our patients and athletes. So protein get it in get it in where it fits in even if it's a bigger dose than previously you may have been led to believe would be effective. Courses coming your way really quick. If you want to come learn more about protein, recovery, nutrition from the Fitness Athlete Division, our Level 1 online course starts again April 29th. Our Level 2 online course starts September 2nd. And we have a number of live courses coming your way throughout the year. A couple coming your way the next couple months. We have Zach Long down in Charlotte, North Carolina. That'll be February 24th and 25th. Zach will again be out on the road, this time in Boise, Idaho, March 23rd and 24th. And then we have a doubleheader the weekend of April 13th and 14th. Joe Hineska will be out in Renton, Washington, near Seattle. And Mitch Babcock will be down in Oklahoma City, Oklahoma. So I hope you have a wonderful Friday. Please join us at CSM if you're going to be there. 5 a.m. tomorrow morning, CrossFit Southie. Other than that, we hope you have a great Friday. Have a great weekend. Bye, everybody. OUTRO Hey, thanks for tuning in to the PT on Ice daily show. If you enjoyed this content, head on over to iTunes and leave us a review, and be sure to check us out on Facebook and Instagram at the Institute of Clinical Excellence. If you're interested in getting plugged into more ice content on a weekly basis while earning CEUs from home, check out our virtual ice online mentorship program at ptonice.com. While you're there, sign up for our Hump Day Hustling newsletter for a free email every Wednesday morning with our top five research articles and social media posts that we think are worth reading. Head over to ptonice.com and scroll to the bottom of the page to sign up.

Uno studio di un gruppo di scienziati britannici dell'University of Cambridge e pubblicato su 'Cell Reports' sottolinea come il digiuno intermittente sia in grado di ridurre l'infiammazione che è alla base di una serie di malattie croniche. A Obiettivo Salute il commento della prof.ssa Debora Rasio, medico nutrizionista, oncologa, ricercatrice all'Università La Sapienza di Roma.

References J Immunol. 2009 Feb 1; 182(3): 1641–1647. Cell Reports 2015 10, 2043-2054DOI Virchows Archiv:European Journal of Pathology. 2020. 09456317, Vol. 476, Issue 2 Poe, EA. 1845. "the Raven" https://youtu.be/wAdQ3CcPHQU?si=2qpStYF2gdUJ4f35 Buddy Morrow and his Orchestra. 1960. "the Black Cat" https://youtu.be/9w_VL7oq-mE?si=XiorgTkvSGzJ4BK0 --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

Me Siga: https://linktr.ee/ericrocha001e Existem alguns estudos interessantes publicados nos últimos anos no periódico "Cell Reports", mostrando que pessoas que tiram um cochilo de 20 minutos dentro das quatro horas após um período de aprendizado conseguem aprender muito mais rápido. Em outras palavras, o cérebro se reorganiza mais rapidamente, com uma reprodução acelerada dos neurônios, cerca de 10 a 20 vezes mais rápido do que o normal. --- Send in a voice message: https://podcasters.spotify.com/pod/show/ericrocha/message

Can we stop the progression of pancreatic cancer? Pancreatic cancer is expected to be the second leading cause of cancer deaths by 2030. It spreads quickly and is hard to manage due to the tumor's unique biological makeup. However, an investigation in Cell Reports revealed the tumor's genetic changes as it spreads through the body. This new information has led to the discovery of an experimental drug that could halt this process and stop the cancer from migrating (University of Rochester). Is it time for parents to be selfish? In the early days of parenting, there's many sleepless nights, forgotten meals, and sick days that we power through because our children need us…but neglecting our own well being may actually be hurting our kids. A study published in Frontiers In Psychology has found that young kids with fathers who have mild anxious or depression symptoms report fewer behavioral difficulties and better scores on a standardized IQ test. More research is needed to reveal the factors that connect these two observations (McGill University). Science is taking muscle repair to the next level Skeletal muscles are one of the most regenerative organ systems we have, but when faced with something more serious, our body could use some help. Research published in Nature Cell Biology has identified a key gene used in muscle repair that brings us one step closer to lab-made muscles. The scientists hope to move this research into fixing rotator cuff tears, before advancing into more difficult challenges, like genetic muscular diseases (UC Irvine). Concussions may trigger mental health issues A study published in the Journal of Athletic Training studied how this brain injury is connected to suicide. Researchers found that male teens who've had two or more concussions in the past year are more likely to report having suicidal thoughts, planning, and attempts than male teens with one or no concussions. The risk of suicidal behavior seems to be the same for female teens regardless of brain injury (University of Michigan). Learn More: https://radiohealthjournal.org/medical-notes-why-parents-should-be-more-selfish-how-scientists-are-creating-lab-made-muscle-and-do-concussions-lead-to-suicidal-thoughts Learn more about your ad choices. Visit podcastchoices.com/adchoices

In this episode, Dr. Luca Pellegrini is interviewed by Olivia Hillier, with narration by Andrew Cao, from the University of Ottawa. Dr. Pellegrini is a new professor in the department of Biochemistry, Microbiology, and Immunology and is an expert on mitochondria and  inter-organelle contacts. He joins us to discuss his team's most recent paper, published in Cell Reports (https://doi.org/10.1016/j.celrep.2021.108873). This publication describes his team's discovery of the “wrappER”, a microscopic superhero in your body that plays a vital role in keeping you in top shape. Dr. Pellegrini takes us through the history of inter-organelle contacts research, the intriguing results detailed in his paper, and the broader implications of his findings to human health.  Learn more: https://www.pellegrinilab.com/ 0:27 | Podcast team introduction0:42 | Meet the wrappER, the cloak that safeguards your metabolic health.2:02 | Meet Dr. Luca Pellegrini, the founder of the wrappER.3:00 | How did Dr. Pellegrini come to study the wrappER?3:46 | Why does Dr. Pellegrini like history so much?4:41 | When did researchers start to consider how contacts between organelles may be important?5:58 | Diseases related to defects in inter-organelle contacts.6:48 | What you need to know about  Anastasia et al., 2021: the paper that discovered and defined the wrappER.8:12 | The wrappeR's structure is like a burrito.8:43 | Are all mitochondria wrapped by the wrappER?9:01 | The wrappER is not limited to liver cells.9:38 | What else can the wrappER wrap?10:12 | Dynamics of the wrappER and mitochondria.11:32 | How long did it take to make these discoveries of the wrappER?11:44 | The team behind the discovery.12:40 | What the wrappER can teach us about how our bodies regulate fat.13:18 | The wrappER and treatments for fat-related diseases and disorders.13:55 | Dr. Pellegrini's plans as a new profressor and principal investigator at the University of Ottawa.14:22 | Wrapping up: thank you to Dr. PellegriniPodcast by Andrew Cao (Narrator and Post-Production), Olivia Hillier (Interviewer), Olivia Sommers (Producer), & Anna Wang (Writer-Editor).Music:“The Launch” by Chronox (https://freemusicarchive.org/music/Chronox_2/)  This song can be found on the Free Music Archive (https://freemusicarchive.org/music/Chronox/Voyager/Chronox_-_01_-_The_Launch/)“Nocturnal (BGM)” by LEMMiNO (https://www.lemmi.no/)  “Thannoid” by Blue Dot Sessions (https://www.sessions.blue/)   “Are We Loose Yet” by Blue Dot Sessions (https://www.sessions.blue/)   “Here” by Hyson (https://iamhyson.bandcamp.com/)   

Brain cancer linked to nuclear pore alterations  Transcript of this podcastHello and welcome to the NanoLSI podcast. Thank you for joining us today. In this episode we feature the latest research by Masaharu Hazawa and Richard Wong at the Kanazawa University NanoLSI, alongside Mitsutoshi Nakada and colleagues at Kanazawa University.The research described in this podcast was published in Cell Reports in August 2023 Kanazawa University NanoLSI websitehttps://nanolsi.kanazawa-u.ac.jp/en/Brain cancer linked to nuclear pore alterations Researchers at Kanazawa University report in Cell Reports how alterations in nuclear pores lead to the degradation of anti-tumor proteins. Several types of cancer are believed to be linked to alterations of macromolecular structures known as nuclear pore complexes.  These structures are embedded in the nuclear envelope, a membrane barrier that separates the nucleus of a cell from the cytoplasm (the liquid filling the rest of the cell).  They consist of proteins called nucleoporins, which regulate the transport of molecules across the nuclear envelope, including enzymes that enable the synthesis of DNA.  Whether nuclear pore complex alterations play a role in glioblastoma, the most common type of cancer originating in the brain, is unclear at the moment.  Now, Masaharu Hazawa, Mitsutoshi Nakada and Richard Wong from Kanazawa University and colleagues have found a link between the functioning of nuclear pore complexes and glioblastoma — specifically, they demonstrated the inactivation of a tumor-suppressing protein called p53. The protein p53 is crucial in cancer prevention.  The corresponding gene TP53 encodes proteins that prevent mutations of the genome and is the most frequently mutated gene in human cancers.  Gaining insights into how p53 inactivation happens is crucial for understanding tumorigenesis in general and glioblastoma in particular.So how did the researchers go about it?Mitsutoshi Nakada and Richard Wong and colleagues first checked whether any nuclear pore complex proteins were amplified (that is ‘overexpressed') in glioblastoma.  They found that one such protein, called NUP107, showed overexpression.  Further investigations revealed that NUP107 is a potential oncoprotein in glioblastoma; its overexpression degrades the function of the cancer-suppressing p53 protein.  They also found that MDM2, another protein, is overexpressed simultaneously with NUP107.  MDM2 is also known to mediate p53 protein degradation. Further studies will be necessary to uncover the full molecular pathways at play, but the scientists speculate that the increased amount of NUP107 proteins in the nuclear pore complexes of glioblastoma cells results in nuclear pore complex structures that regulate the transport of molecules from the nucleus to the cytoplasm in a way that promotes p53 degradation.  This scenario is referred to as nuclear transport surveillance.  Experiments in which NUP107 proteins were depleted re-activated p53, consistent with NUP107 providing the structural stability of glioblastoma NPCs. The findings of Mitsutoshi Nakada and Richard Wong and colleagues confirm that alterations of nuclear pore complexes contribute to the pathogenesis of glioblastoma.  As Mitsutoshi Nakada and Richard Wong put it : “Together, our findings establish roles of nuclear pore complexes in transport surveillance and provide insights into p53 inactivation in glioblastoma.”  ReferenceDini Kurnia Ikliptikawati, Nozomi Hirai, Kei Makiyama, Hemragul Sabit, Masashi Kinoshita, Koki Matsumoto, Keesiang Lim, Makiko Meguro-Horike, Shin-ichi Horike, Masaharu Hazawa, Mitsutoshi Nakada, and Richard&NanoLSI Podcast website

Die Themen in den Wissensnachrichten: +++ Nach Russland fliegt jetzt Indien zum Mond +++ Dracula könnte blutige Tränen geweint haben +++ Kloschüssel ohne Bremsspuren +++**********Weiterführende Quellen zu dieser Folge:Chandrayaan-3 Mission/ X, 21.08.2023Count Dracula Resurrected: Proteomic Analysis of Vlad III the Impaler's Documents by EVA Technology and Mass Spectrometry/ Analytic Chemistry, 08.08.203Adaptive expression of engrams by retroactive interference/ Cell Reports, 16.08.2023POMPEII: THE LIFE OF SLAVES IN CIVITA GIULIANA/ Pompeji Sites, 20.08.2023Evolution of Neptune at near-infrared wavelengths from 1994 through 2022/ Icarus, 01.11.2023Abrasion-Resistant and Enhanced Super-Slippery Flush Toilets Fabricated by a Selective Laser Sintering 3D Printing Technology/ Advanced Engineering Materials, 05.08.2023**********Ihr könnt uns auch auf diesen Kanälen folgen: Tiktok und Instagram.**********Weitere Wissensnachrichten zum Nachlesen: https://www.deutschlandfunknova.de/nachrichten

References Immunity 2022. 55, Issue 8. Pages 1402-1413. Methods Mol Biol. 2018;1675:167-181. Experimental & Molecular Medicine 2019. volume 51, Article number: 80. Cell Reports 2015 10, 2043-2054DOI: (10.1016/j.celrep.2015.02.057) --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message

Estudo publicado no Cell Reports revela que o cheiro a novo nos carros vem de químicos cancerígenos em quantidades acima do aceitável. Fazer longas viagens com calor em carros novos aumenta o risco de cancro

The 2019 Cell Reports paper, “Chromatin Remodeling in Response to BRCA2-Crisis” by J Gruber and M Snyder et al. is available online here.Dr. Michael Snyder's Stanford laboratory home page is here.A 1998 Oncogene paper, “The BRCA2 is a histone acetyltransferase” by S Habibur and E S P Reddy et al. is located online here. A 2014 Cancer Discovery paper, “R-loop Processing by BRCA2 is Required for Genomic Stability” is located here. And more about TIP60 can be found in this recent 2022 Oncogenesis reference, “The TIP60-ATM axis regulates replication fork stability in BRCA-deficient cells” located online here. If you would like to contact Dale, Cindy or Sarantis feel free to email us at info@olink.com and if you would like to learn more about our backgrounds, Cindy's LinkedIn is here, Sarantis' is here, and Dale's is here.In case you were wondering, Proteomics in Proximity refers to the principle underlying Olink Proteomics assay technology called the Proximity Extension Assay (PEA), and more information about the assay and how it works can be found here.Would you like to subscribe to the podcast on your favorite player or app? You can do so here: Apple Podcasts: https://apple.co/3T0YbSm Spotify Podcasts: https://open.spotify.com/show/2sZ2wxOqI4b4vSngkajLs8?si=d957d55c8db046f7 Google Podcasts: https://podcasts.google.com/feed/aHR0cHM6Ly9mZWVkcy50cmFuc2lzdG9yLmZtL3Byb3Rlb21pY3MtaW4tcHJveGltaXR5 Amazon Music: https://music.amazon.com/podcasts/d97ace94-f02b-4b37-9532-799548ef2840 Podcast Addict: https://podcastaddict.com/podcast/4098296 Deezer: https://www.deezer.com/show/5178787 Player FM: https://player.fm/series/series-3396598

Videos : Experts try to calm the angry AI, w Elon Musk  Neil Oliver: ‘Don't be fooled into thinking this disaster movie is coming to an end' (11:25) The TRUTH about IVERMECTIN (13:00) Liz Question  Greater niacin intake linked with lower mortality risk among cancer patients during 15-year period First People's Hospital in China, November 21 2022.  A study reported  in BMC Cancer found that men and women with cancer who consumed a higher amount of niacin (vitamin B3) from food or supplements had a lower risk of dying from the disease during a 15-year follow-up period than patients with lower consumption.  Researchers analyzed data from 3,504 cancer patients who participated in the National Health and Nutrition Examination Surveys (NHANES) between 1999 and 2014.  Among participants whose niacin intake from food was among the top 25%, the adjusted risk of mortality from all causes was 27% lower, and the risk of dying from cancer was 49% lower during follow-up compared with participants whose intake was among the lowest 25%. Each 10 mg per day increase in dietary niacin was associated with an adjusted 11% lower risk of all-cause mortality and a 19% reduction in the risk of cancer mortality.  Total daily niacin intake was 76.4 mg per day among participants who reported using niacin supplements compared to 21.4 mg per day among those who did not supplement. Cancer mortality was 52% lower among those who supplemented with niacin versus unsupplemented participants.  “Our study found that higher intake of dietary niacin was associated with lower risk of mortality from all-causes and cancer mortality,” Hongyan Ying Taizhou of First People's Hospital in China and colleagues concluded. “The consumption of niacin had a dose-effect relationship for all-cause mortality, but not for cancer mortality. This conclusion was verified by the data of supplemental niacin consumption.” Study: Antioxidant flavonols linked to slower memory decline Rush University Medical Center, November 22, 2022 People who eat or drink more foods with antioxidant flavonols, which are found in several fruits and vegetables as well as tea and wine, may have a slower rate of memory decline, according to a study published in Neurology. “It's exciting that our study shows making specific diet choices may lead to a slower rate of cognitive decline,” said study author Thomas M. Holland, MD, MS of Rush University Medical Center in Chicago. “Something as simple as eating more fruits and vegetables and drinking more tea is an easy way for people to take an active role in maintaining their brain health.” The study involved 961 people with an average age of 81 without dementia. They filled out a questionnaire each year on how often they ate certain foods. They also completed annual cognitive and memory tests including recalling lists of words, remembering numbers and putting them in the correct order. They were also asked about other factors, such as their level of education, how much time they spent doing physical activities and how much time they spent doing mentally engaging activities such as reading and playing games. They were followed for an average of seven years. The people were divided into five equal groups based on the amount of flavonols they had in their diet. While the average amount of flavonol intake in US adults is about 16 to 20 milligrams (mg) per day, the study population had an average dietary intake of total flavonols of approximately 10 mg per day. The lowest group had an intake of about 5 mg per day and the highest group consumed an average of 15 mg per day; which is equivalent to about one cup of dark leafy greens. After adjusting for other factors researchers found that the cognitive score of people who had the highest intake of flavonols declined at a rate of 0.4 units per decade more slowly than people whose had the lowest intake. Holland noted this is probably due to the inherent antioxidant and anti-inflammatory properties of flavonols. The study also broke the flavonol class down into the four constituents: kaempferol, quercetin, myricetin and isorhamnetin. The top food contributors for each category were: kale, beans, tea, spinach and broccoli for kaempferol; tomatoes, kale, apples and tea for quercetin; tea, wine, kale, oranges and tomatoes for myricetin; and pears, olive oil, wine and tomato sauce for isorhamnetin. People who had the highest intake of kaempferol had a 0.4 units per decade slower rate of cognitive decline compared to those in the lowest group. Those with the highest intake of quercetin had a 0.2 units per decade slower rate of cognitive decline compared to those in the lowest group. And people with the highest intake of myricetin had a 0.3 units per decade slower rate of cognitive decline compared to those in the lowest group. Dietary isorhamnetin was not tied to global cognition. Examining how poor diet damages blood vessels Leipzig University & Helmholtz Institute for Metabolic, Obesity and Vascular Research (Germany), November 21, 2022 A research team led by Bilal Sheikh from the Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) and Leipzig University's Faculty of Medicine investigated how obesity impacts blood vessels' structure at a molecular level. The team's research, now published in Nature Metabolism, illustrates that metabolic disease affects blood vessels in different organs of our body in a unique way. For instance, blood vessels in the liver and fat tissue struggle to process the excess lipids, kidney vessels develop metabolic dysfunction, lung vessels become highly inflammatory, and transport across the brain vessels is defective.  “As vascular dysfunction drives all major pathologies, from heart failure to atherosclerosis and neurodegeneration, our research shows how bad eating habits molecularly promote the development of diverse diseases,” explains Dr. Olga Bondareva, the first author of the study. “We want to elucidate molecular mechanisms of obesity in order to be able to offer patients tailor-made therapies in the future,” adds HI-MAG director Professor Matthias Blüher. Blüher has been conducting research on morbid obesity at Leipzig University for years. The present study also involves scientists from Leipzig who work in the fields of cardiology and laboratory medicine. The researchers then asked whether a healthy diet could reduce the disease-causing molecular signatures induced by a bad diet. Their results show that a healthy diet can indeed improve the molecular health of blood vessels, albeit only partially. For instance, the blood vessels in the liver recovered nearly completely, but blood vessels in the kidneys retained the disease signature, despite a healthy diet and significant weight loss. This means that some of our blood vessels can develop a “memory” of metabolic disease, which is difficult to reverse. Lab mice fed processed food found to fare worse against flu than those eating grains University of Sydney & Shenzhen University School of Medicine (China), November 21, 2022 A team of researchers at the University of Sydney working with a colleague from Shenzhen University School of Medicine has found that lab mice are more likely to survive a flu infection if they are fed grain-based foods rather than processed food. The paper is published in Cell Reports. In recent years, medical researchers have reported evidence that diet plays a larger role in illness recovery than was thought. Some studies have shown, for example, that caloric density and the concentration of nutrients consumed while recovering from an infection can have a major impact on the severity of the infection. In this new effort, the researchers found evidence suggesting that other characteristics of food can also play a role in illness recovery, at least in mice. In this new effort, the researchers were studying how mammals such as mice fight off influenza infections. As part of that effort, they inadvertently fed two groups of lab mice slightly different meals that were thought to be equivalent in nutritional value and hence unlikely to have an impact on disease recovery. More specifically, they fed one group of mice a diet consisting mostly of grains. The other mice were fed a highly processed diet.  Both groups were subsequently infected with the influenza virus and were kept on the same diets they had prior to being infected. The researchers note that prior studies had shown that mice fed either diet when not battling an infection displayed little difference in health or behavior. But when infected with influenza, the researchers found that all of those fed the highly processed diet died. They also found that those fed the highly processed diet failed to regain weight lost due to the illness. In sharp contrast, all of the mice on the grain-based diet began regaining weight within 10 days of initial infection, and all of them recovered. The researchers note that the difference in survival was not due to differences in an immune response, but was instead due to recovery issues. They note that the mice on the highly processed food diet ate less than those given grains and wound up getting less nutrients.  Study: Olive Leaf Extract as Effective as Typical Diabetes Drugs University of Auckland  (New Zealand), November 17, 2022 Researchers from the University of Auckland have discovered that olive leaf extract has the ability to decrease insulin resistance and increase the production of insulin by the pancreas. This is one of the main problems that most diabetes patients suffer from – the lack of proper insulin balance in the body. To test olive leaf extract's effects on diabetes, the researchers conducted a randomized, double-blinded and placebo-controlled clinical study dividing 46 overweight men into two groups. One of the groups received olive leaf extract, while the other group was given a placebo. The olive leaf extract was standardized to contain its active ingredients – oleuropein and hydroxytyrosol. After six weeks to allow the men's bodies to return to their ‘normal levels,' the groups were switched. The original placebo group then received the olive leaf extract, and vice versa.  None of the men knew which group they were in at which time. The researchers found that the olive leaf extract lowered insulin resistance by an average of 15% and increased the productivity of the pancreas' beta cells – which produce insulin – by 28%. The researchers concluded: “Supplementation with olive leaf polyphenols for 12 weeks significantly improved insulin sensitivity and pancreatic β-cell secretory capacity in overweight middle-aged men at risk of developing the metabolic syndrome.” This research also showed that olive leaf could possibly effectively treat both Diabetes 1 and Diabetes type 2. In addition, the olive leaf extract would likely help individuals with type 2 Diabetes the most. Researchers also found that olive leaf extract may be just as effective as conventional drugs. They stated: “Hence, compared to these drugs that only improve insulin secretion, olive leaf extract improves both insulin sensitivity and pancreatic β-cell secretory capacity. Remarkably, the observed effects of olive leaf extract supplementation in our study population is comparable to common diabetic therapeutics (particularly metformin)…” Common Painkillers Like Ibuprofen And Naproxen Can Make Arthritis Inflammation Even Worse University of California-San Francisco, November 20, 2022 Common painkillers can make the misery of osteoarthritis even worse, a new study warns. Ibuprofen, naproxen, and diclofenac are among the many drugs for relieving aching joints. However, researchers say they may aggravate inflammation of the knee over time. They belong to a class of medications known as NSAIDS, or non-steroidal anti-inflammatory drugs. The study, based on a review of over 1,000 patients, is one of the first to investigate their long-term effects. “NSAIDs are frequently used to treat pain, but it is still an open discussion of how NSAID use influences outcomes for osteoarthritis patients. In particular, the impact of NSAIDs on synovitis, or the inflammation of the membrane lining the joint, has never been analyzed using MRI-based structural biomarkers.” The team found no benefit in 277 patients with moderate to severe osteoarthritis who also engaged in sustained NSAID use. In fact, joint inflammation and cartilage quality got worse over the next four years compared to a group of 793 controls who did not take the drugs. Dr. Luitjens and her colleagues looked at the link between NSAIDs and synovitis and assessed how the therapy impacted joint structure over time. “Synovitis mediates development and progression of osteoarthritis and may be a therapeutic target,” Dr. Luitjens continues. “Therefore, the goal of our study was to analyze whether NSAID treatment influences the development or progression of synovitis and to investigate whether cartilage imaging biomarkers, which reflect changes in osteoarthritis, are impacted by NSAID treatment.” “In this large group of participants, we were able to show that there were no protective mechanisms from NSAIDs in reducing inflammation or slowing down progression of osteoarthritis of the knee joint,” the study author reports. “The use of NSAIDs for their anti-inflammatory function has been frequently propagated in patients with osteoarthritis in recent years and should be revisited, since a positive impact on joint inflammation could not be demonstrated.”

How are habits – both good and bad – formed in the brain, and what role do habits play in diseases of the brain? These are some of the questions neuroscientist, Talia Lerner, PhD, is investigating in her lab. Her recent study, published in Cell Reports, may change the overall understanding of how habits are formed and could be broken.

VIDEOS: Dr. Ryan Cole: Covid Vaccine Side Effects Are Like A Nuclear Bomb (10:00) We don't need the CIA – The Chris Hedges Report (10:00)   GlyNAC supplementation reverses aging hallmarks in aging humans Baylor College of Medicine, August 19, 2022 A randomized, double blind human clinical trial conducted by researchers at Baylor College of Medicine reveals that supplementation with GlyNAC—a combination of glycine and N-acetylcysteine—improves many age-associated defects in older humans and powerfully promotes healthy aging. This is relevant because until now, there have been no solutions toward improving many of these age-related declines in people. Published in The Journals of Gerontology: Series A, the study shows that older humans taking GlyNAC for 16-weeks improved many characteristic defects of aging. This includes oxidative stress, glutathione deficiency and multiple aging hallmarks affecting mitochondrial dysfunction, mitophagy, inflammation, insulin resistance, endothelial dysfunction, genomic damage, stem cell fatigue and cellular senescence. These were associated with improvements in muscle strength, gait speed, exercise capacity, waist circumference and blood pressure. The improvements in oxidative stress, glutathione levels and mitochondrial function in the muscle tissue of older humans taking GlyNAC were similar to the improvements in organs such as the heart, liver and kidneys of aged mice supplemented with GlyNAC as reported in the researchers' recent publication. Taken together, the results of these studies show that GlyNAC supplementation can improve these defects in many different organs of the body. “GlyNAC supplementation in aging mice increased their length of life mice by 24%,” said Sekhar. “Gait speed is reported to be associated with survival in older humans. Our randomized clinical trial found a significant improvement in gait speed in older humans supplemented with GlyNAC. This raises the interesting question of whether GlyNAC supplementation could have implications for survival in people.” Mitochondria generate energy needed for supporting cellular functions. However, the ability of mitochondria to work well declines as we age. How to improve the ability of these failing mitochondria to work is not well understood, and therefore no solutions have been available. Sekhar's group discovered earlier that supplementing GlyNAC in aged mice corrected malfunctioning mitochondria. However, to definitively determine whether GlyNAC supplementation benefited people, a placebo-controlled randomized clinical trial was required. After 16-weeks of GlyNAC supplementation, mitochondrial function of older people improve toward levels found in young people. This was accompanied by improvements in multiple additional outcomes as reported in the publication. Analysis of the molecular data from the trial suggests that the GlyNAC supplementation is able to fill cells with younger and more efficient mitochondria. “Collectively these exciting new discoveries hold great promise for improving our mitochondrial and general health as we age,” Sekhar said. A second vital benefit offered by supplementing GlyNAC is that it also helps protect the body from an important problem called oxidative stress. GlyNAC supplementation corrects glutathione deficiency and lowers oxidative stress in older humans back to youthful levels, thereby solving both problems. “One of the intriguing questions from this trial is why so many improvements occur toward promoting health. We believe that this is due to the combined effort of three separate components—glycine, cysteine (from NAC) and glutathione, and not just due to glutathione itself. Glycine and cysteine are both very important for cellular health on their own, and GlyNAC provides both. Glycine and cysteine are building blocks to form glutathione, which also has health benefits. We believe that the improvements in this trial and in our previous studies are the result of the combined effects of glycine and NAC and glutathione, and we refer to this combination as the ‘Power of 3,'” said Sekhar. GlyNAC supplementation improved muscle strength in the upper and lower extremity and a trend toward increased exercise capacity. “These findings could have additional implications for improving the health of older humans, especially in terms of being able to be more physically active,” said Sekhar. High-fructose corn syrup consumption in adolescence impairs learning and memory University of Southern California, August 12, 2022 Because most corn in America is genetically modified to kill corn “pests,” no human on Earth should be eating it, especially every day. This is now being proven by scientists who run tests on animals in laboratories and have concluded that high-fructose corn syrup (HFCS) and sucrose can impair an adolescent animal's ability to learn, and it can impair its ability to remember information. And that brings us to the rat genome. Research reveals a difference between adult animals that consume HFCS-sweetened beverages and adolescent animals that consume the same. The amounts of HFCS used in the research were very similar to the amounts of GMO sugar found in common soft drinks. The study was conducted over one month. The lead author of the study said it's no secret that soft drinks can lead to not only metabolic disturbances but interference with the brain's ability to function normally and remember “critical information” about one's environment. Dr. Scott Kanoski from the University of Southern California explained, “The hippocampus is such a critical brain region for memory function. In many ways this region is a canary in the coal mine, as it is particularly sensitive to insult by various environmental factors, including eating foods that are high in saturated fat and processed sugar.” Music More Effective Than Drugs At Releasing Brain's Painkillers McGill University (Montreal), August 11, 2022 400 published scientific papers have proven the old adage that “music is medicine.” Neurochemical benefits of music can improve the body's immune system, reduce anxiety levels and help regulate mood in ways that drugs have difficulty competing. “We've found compelling evidence that musical interventions can play a health care role in settings ranging from operating rooms to family clinics,” says Prof. Levitin of McGill University's Psychology Department. “But even more importantly, we were able to document the neurochemical mechanisms by which music has an effect in four domains: management of mood, stress, immunity and as an aid to social bonding.” Like other pleasurable experiences, there are two components to enjoying music: anticipation of hearing your favourite song, and then actually hearing it. The brain signalling chemical dopamine, which is linked to reward, is involved in both phases. But neuroscientists have wondered for decades whether there was more to it — what gives music its power to induce euphoria? The brain's natural opioids could be key. Professor Levitin's team showed that blocking opioid signals in the brain by giving people a drug called naltrexone reduces the amount of pleasure they report getting from their favourite song. They still enjoy the anticipation of hearing the song just as much, suggesting that, although dopamine is involved, it's when the opioids kick in that music really starts to affect our minds. A flood of opioids would also explain music's effect on our body. Listening to music is known to raise people's pain thresholds, so much so that in some cases, it can be used to reduce the need for morphine-like painkillers. In their analysis, Levitin's team surveyed over 400 papers, looking for patterns in the scientific evidence supporting the claim that music can affect brain chemistry in a positive way. They succeeded in isolating four areas where music can help: Reward, motivation, and pleasure (to help with eating disorders, as an example) Stress and arousal (to help reduce anxiety) Immunity (to strengthen the body's immune system and slow-down age related decline) Social affiliation (to assist in trust building and social bonding) The researchers connected these areas with four primary neuro-chemical systems: Dopamine and opioids Cortisol (and related hormones) Serotonin (and related hormones) Oxytocin “We know music facilitates active neurochemical processes in a symphony of opioids which pharmaceutical intervention has been unable to match,” said Dr. Francis Chandra commenting on the study. Calcium & magnesium reduce risk of metabolic syndrome: 9000-strong study Case Western Reserve University, August 14, 2022 Calcium and magnesium may reduce the risk of metabolic syndrome – but men need above and beyond recommended levels for this effect, say researchers. The researchers from the Case Western Reserve University in the US used 9,148 adults to test the theory that higher dietary intakes of calcium and magnesium decreased the risk of metabolic syndrome. Using 24-hour recalls as part of the National Health and Nutrition Examination Study, they found women who met the US recommended dietary allowance (RDA) for both magnesium (310–320 mg per day) and calcium (1000–1200 mg per day) saw the greatest decrease in risk of metabolic syndrome. The European RDA for magnesium is 375 mg and 800 mg for calcium. Meanwhile, they did not see the same association for men meeting the RDA for magnesium (400–420 mg per day) and calcium (1000–1200 mg per day), individually or in combination. However, when these intakes were increased to over 386 mg for magnesium and over 1224 mg per day for calcium, the odds of metabolic syndrome for the men was lowered. “The underlying mechanisms driving the differences we and others have observed by sex are not well understood and warrant additional mechanistic studies,” the researchers wrote. The study measured serum triglyceride, high-density lipoprotein (HDL) cholesterol and glucose levels as markers of the condition Treadmill exercise shown to improve Parkinson's symptoms in mice Rush University Medical Center, August 18, 2022 Regular treadmill exercise helped improve Parkinson's disease symptoms in mice in a recent study by researchers at RUSH University Medical Center. The results of the study were recently published in the Cell Reports. “We're very excited about the results,” said Kalipada Pahan, Ph.D., Floyd A. Davis, MD, Endowed Chair in Neurology and professor of neurological sciences, biochemistry, pharmacology at the RUSH University Medical Center. “Our hope is that we can use this as a jumping off point for furthering our ability to help Parkinson's patients manage their symptoms.” In the study, scientists found positive results in using regular treadmill exercise to stop the spread of the α-synuclein protein and reverse biochemical, cellular, and anatomical changes that occur in the brains of mice with Parkinson's disease in the absence of any drugs. The mice in the trial ran on a treadmill consistently in 30-minute intervals for six days a week, over the course of two months. The findings are key in the ongoing research of Parkinson's, but Pahan and his team were quick to note that while treadmill exercise is something that can be easily available and accessible, some patients with Parkinson's might not be able to run on a treadmill daily. “Once patients are diagnosed with these neurodegenerative disorders, there are no drugs available for halting the disease progression,” Pahan said. “Understanding how the treadmill helps the brain is important to developing treadmill-associated drugs that can inhibit α-synuclein pathology, protect the brain, and stop the progression of Lewy body diseases.” 30 Minutes of Reading a Day Could Add Years to Your Life University of Sussex (UK) and Yale University, August 7, 2022 Past studies have shown that reading books can benefit people in a multitude of ways, physically, mentally, and intellectually. Now in a new study, people who read a book for about 30 minutes a day were found to live approximately 2 years longer than those who didn't read at all. In previous research, curling up with a good book has been shown to improve people's social skills by improving their ability to read the thoughts and feelings of others. Researchers at the University of Sussex in England found that reading was “the most effective way to overcome stress” – even better than listening to music, having a cup of tea, or going for a walk. Reading has also been proven to be a great way to keep the mind sharp, and may reduce mental decline by 32%, helping to prevent Alzheimer's disease. For the new study, researchers from Yale University analyzed data on 3,635 people age 50 and older. The participants were divided into 3 groups – those who didn't read at all, those who read up to 30 minutes a day, and those who read for longer than 3.5 hours per week. Those who read the most tended to be women with college educations and high incomes. The researchers said that book readers appear to have a “significant survival advantage” over people who don't read books. The study didn't address whether reading on a Kindle or other tablet device counted, but it did find that book readers in general lived an average of 2 years longer than non-readers. Specifically, the researchers found that people who read up to 3.5 hours a week were 17% less likely to die over the study's 12-year follow-up period than participants who read no books. This was after accounting for the participants' age, race, self-reported health, depression, employment, and marital status. Compared with those who didn't read books, those who read for more than 3.5 hours a week were 23% less likely to die overall.

August 2022The papers behind the pod: Arjmand S et al. (2022). Tips and traps for behavioural animal experimentation. Acta Neuropsychiatrica, in press. https://doi.org/10.1017/neu.2022.4Wrede P et al. (2022). Real-time 3D optoacoustic tracking of cell-sized magnetic microrobots circulating in the mouse brain vasculature. Science Advances 8(19). https://doi.org/10.1126/sciadv.abm9132 Russell A et al. (2022). Reduced housing density improves statistical power of murine gut microbiota studies. Cell Reports 39(6): e110783. https://doi.org/10.1016/j.celrep.2022.110783It's the third Thursday of August, and you're listening to 3 Minute 3Rs, your monthly recap of efforts to replace, reduce, and refine the use of animals in research. Follow this link for the full transcript: https://nc3rs.org.uk/3-minute-3rs-podcast-august-2022-transcript Our GDPR privacy policy was updated on August 8, 2022. Visit acast.com/privacy for more information.

Recent studies (since 2019) provide more clues about the effects of hormones on muscle: The ability to build it The loss of it Plus, in this episode I provide suggestions on what to do that is also noted by science as proven protocols. Study 1 Treating women post menopause with either a placebo or estradiol, the estradiol subjects increased their muscle mass. Adequate exercise is also important: estradiol without proper exercise is less likely to increase lean muscle. It might help slow the rate of losses otherwise associated with age. Remember that muscle loss associated with age, are “associated with age” because the current existing science on lifting heavy weight well into 7th, 8th, and 9th decades is lacking. Studies on weightlifting for the oldest of old are minimal. Those that do exist, are promising. Even moderate, consistent weight training, and protein supplementation continues to improve lean muscle in elderly. We will be the first generation who do lift heavy weights into older age. The loss of estrodiol was directly associated with a lack of muscle when there was no additional stimulus for muscle. What is proven to decrease or prevent muscle loss? Lifting heavier weight, to muscle fatigue Eating higher levels of (and) higher quality complete proteins While reducing stressors Hormone replacement therapy Ko J, Park YM. Menopause and the Loss of Skeletal Muscle Mass in Women. Iran J Public Health. 2021 Feb;50(2):413-414. doi: 10.18502/ijph.v50i2.5362. PMID: 33748008; PMCID: PMC7956097. Study 2 Lean body mass is negatively associated with incident VMS. Our data suggests that maintaining higher levels of LBM during the menopausal transition may be protective against the development of VMS. Every woman will experience menopause in her life and the ability to potentially prevent the onset of specific symptoms through basic interventions, such as resistance training to increase lean body mass, may positively impact this large population. Reduce VMS (hot flashes and night sweats) with increased levels of lean body mass. Woods, R., Hess, R., Biddington, C. et al. Association of lean body mass to menopausal symptoms: The Study of Women's Health Across the Nation. womens midlife health 6, 10 (2020). https://doi.org/10.1186/s40695-020-00058-9 PLUS, STUDY #3 During menopause women have a reduced fatty oxidation during exercise than women pre-menopause. Suggesting the best time to start is in pre-menopause.. the next best time is peri.. or wherever you are if you're not exercising. Gould, Lacey M. MA1; Gordon, Amanda N. BS1; Cabre, Hannah E. MS, RDN1, 2; Hoyle, Andrew T. BS1; Ryan, Eric D. PhD2, 3; Hackney, Anthony C. PhD, DSc2, 4; Smith-Ryan, Abbie E. PhD1, 2, 4 Metabolic effects of menopause: a cross-sectional characterization of body composition and exercise metabolism, Menopause: April 2022 - Volume 29 - Issue 4 - p 377-389 doi: 10.1097/GME.0000000000001932 STUDY #4 Muscle in menopause is not as sensitive to the protein you eat, therefore you need more of it than you have in the past. (And there is evidence we've been undereating protein for a long time, following guidelines determined for 18 yr. olds going to war to prevent disease). During perimenopause adjusting a diet to higher protein and lower carbohydrate (keeping resistant starches however) HERMAN PONTZER, et al., SCIENCE, 13 Aug 2021, Vol 373, Issue 6556, pp. 808-812 DOI: 10.1126/science.abe5017 Collins et al., 2019, Cell Reports 28, 268-381, July 9, 2019 © The Author(s).  https://doi.org/1016/j.celrep.2019.06.025 IN THE ABSENCE of SPECIFIC MUSCLE BUILDING ACTIVITIES and as estrogen declines…. Muscle loss will occur. You have control over specific muscle building activities: Lifting heaviest weights you can to muscle fatigue every set Eating the minimum dose-stimulus of highest quality protein Ensuring your gut health Metabolism slows? The reason you hear that metabolism slows and fat increases, muscle wains… is that few women are lifting weights in a way that overloads their muscles. We've never seen it. Imagine your mother right now. I'll take a stab and say she's in her 80s or approaching or 90s or she's passed. Did she ever lift? Imagine your older sisters and your sister-in-laws. Did they lift? But they gained weight, they experienced fatigue, lack of muscle tone…. And why? They did what was provided to them. And it was “moderate exercise.” The older they got the more encouraged they were to be careful, not to exert too much, or strain. Phooey… They also (to give you an analogy).. very few of them used computers at a very high level. Maybe they've played solitaire, learned to Facetime or use Facebook with their families. And you and I? We're not going to stop, are we? We'll use them until we die. Similarly, if you begin lifting now… at whatever age that is for you… you will gain strength beyond anything a prior generation experienced, beyond what you have now, and improve your body composition and quality of life as you age. You're going to resist the unknown. You're going to be a lone ranger in the weight room at the gym. Look, every time I go to a gym, I attract looks when I grab the dumbbells and perform sprints on the treadmill. Those looks come from women following their partners around, and from young men picking up lighter weights than I am, and from older men, I hear, “You work hard.” As if… I shouldn't or it's different. Because it is. Few women work very hard. And fewer, eat enough to grow muscle after. After a couple years of regular lifting and exercise… did you know? You must have a caloric surplus in order to gain muscle mass. Oh, you may gain some strength up to a point, but if you're fasting all the time, eating one meal a day or even two… do you think you're going to gain muscle? Think again. You're causing your body stress… and low energy availability during and post exercise won't allow muscle building. Especially in women beyond menopause. Lift heavy. Eat higher protein and overall calorie levels that allow muscle gain. Keep your stress levels (all sources) low. From this you have questions.. How to start lifting safely What a diet that is micronutrient-rich, high protein, and void of food sensitivities looks like How to manage a gut experiencing bloat, gas, irregularity Where your walking, yoga, intervals fit in…. And I've got answers. I'll drop a few of them in the show notes. Right now(July 1-15) the Café membership is open. Workouts that are based on protocols for women in menopause are the #1 reason women log into their memberships every week. And… they come back for expert interviews, masterclasses that deep dive into the science on topics you care most about, mini courses so that answers to your highest priority challenge are at your fingertips whenever you want them, and recipes that put Flipping50 -approved food on the table quickly and flavorfully. I'll add a few more links to this episode show notes too in case we're closed. Never do we want someone sitting waiting. I'm a science girl who wants to cut through the junk and find the effective way to get fit not hurt. So, I use science -featuring you – to determine the effects of hormones on exercise and vice versa. This is the 1st, and only exclusively made-for-menopause fitness membership in the world. Resources: The Flipping 50 Membership: https://www.flippingfifty.com/cafe The 5 Day Flip: https://www.flippingfifty.com/5dayflip

Conversamos en mi espacio radial con la Dra. Dadilia Garcés, médico epidemiólogo y profesora del Miami Dade College, sobre el Zika. Un estudio advierte sobre la preocupante capacidad de mutación del virus. Una sola mutación del virus del zika podría provocar un nuevo brote y desencadenar una propagación «explosiva», advirtieron investigadores estadounidenses. En 2016, esta enfermedad causó una emergencia de salud mundial. Miles de bebés, muchos de ellos en Brasil, nacieron con daño cerebral después de que sus madres se infectaran durante el embarazo. Ahora los científicos exhortaron a estar atentos a nuevas mutaciones, luego de realizar un estudio de laboratorio (publicado en la revista Cell Reports) que sugiere que el patógeno tiene un gran potencial de cambiar fácilmente. Los estudios sugieren que las nuevas variantes podrían ser efectivas para propagarse, incluso en países que han desarrollado inmunidad por brotes anteriores. Los expertos dijeron que los hallazgos, aunque teóricos, son un recordatorio de que otros virus aparte del COVID-19 podrían representar una amenaza. El Zika se transmite por las picaduras del Mosquito Aedes Aegypti cuando está infectado. Los insectos se encuentran en América, excepto en Canadá y Chile, donde por el frío no sobrevivan. También se encuentran en toda Asia. Si bien para la mayoría de las personas es una enfermedad leve, sin efectos duraderos, puede tener consecuencias catastróficas para bebés en el útero. Detalles sobre el zika: - Aunque el virus es transmitido por mosquitos, también puede transmitirse sexualmente. - Sus síntomas pueden incluir fiebre, erupción cutánea y dolor en articulaciones. - Como no hay tratamiento de debe reducir el riesgo de ser picado. - Científicos han comenzado a trabajar en una vacuna contra el zika para proteger a las embarazadas. Si quieres saber sobre el Zika … Disfruta de la entrevista y escucha mi programa de radio, A Tu Salud La Revista, de lunes a viernes, de 3 a 5pm, por la @LaRomantica889 en Caracas, en www.laromantica.fm y en las emisoras del interior del Circuito Romántico.

In this episode of the Epigenetics Podcast, we caught up with Eleni Tomazou from St. Anna Children's Cancer Research Institute in Vienna to talk about her work on Epigenome-based precision medicine. The Tomazou lab studies Ewing sarcoma and the effects of Epigenetic factors on this disease. Ewing sarcoma is a type of cancer that affects bone and soft tissue of children and young adults, with a peak incidence at the age of 15. Ewing sarcoma is among the pediatric cancer types with the lowest survival rates and the development of novel therapies was obstructed by the limited understanding of the mechanisms behind the disease. Work done in Eleni Tomazou's group identified an epigenetic signature of Ewing sarcoma which, ultimately, lead to the possibility to diagnose Ewing sarcoma from liquid biopsies. The team is now looking to find actionable targets like enhancers to develop therapies, finding biomarkers to enable disease monitoring, and to further characterize these tumors to decipher intra-tumor epigenetic heterogeneity and characterize the developmental stage of the cell of origin.   References Tomazou, E. M., Sheffield, N. C., Schmidl, C., Schuster, M., Schönegger, A., Datlinger, P., Kubicek, S., Bock, C., & Kovar, H. (2015). Epigenome Mapping Reveals Distinct Modes of Gene Regulation and Widespread Enhancer Reprogramming by the Oncogenic Fusion Protein EWS-FLI1. Cell Reports, 10(7), 1082–1095. https://doi.org/10.1016/j.celrep.2015.01.042 Sheffield, N. C., Pierron, G., Klughammer, J., Datlinger, P., Schönegger, A., Schuster, M., Hadler, J., Surdez, D., Guillemot, D., Lapouble, E., Freneaux, P., Champigneulle, J., Bouvier, R., Walder, D., Ambros, I. M., Hutter, C., Sorz, E., Amaral, A. T., de Álava, E., … Tomazou, E. M. (2017). DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma. Nature Medicine, 23(3), 386–395. https://doi.org/10.1038/nm.4273 Terlecki-Zaniewicz, S., Humer, T., Eder, T., Schmoellerl, J., Heyes, E., Manhart, G., Kuchynka, N., Parapatics, K., Liberante, F. G., Müller, A. C., Tomazou, E. M., & Grebien, F. (2021). Biomolecular condensation of NUP98 fusion proteins drives leukemogenic gene expression. Nature Structural & Molecular Biology, 28(2), 190–201. https://doi.org/10.1038/s41594-020-00550-w Peneder, P., Stütz, A. M., Surdez, D., Krumbholz, M., Semper, S., Chicard, M., Sheffield, N. C., Pierron, G., Lapouble, E., Tötzl, M., Ergüner, B., Barreca, D., Rendeiro, A. F., Agaimy, A., Boztug, H., Engstler, G., Dworzak, M., Bernkopf, M., Taschner-Mandl, S., … Tomazou, E. M. (2021). Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden. Nature Communications, 12(1), 3230. https://doi.org/10.1038/s41467-021-23445-w   Related Episodes Epigenomics (Henk Stunnenberg) Targeting COMPASS to Cure Childhood Leukemia (Ali Shilatifard) Cancer and Epigenetics (David Jones)   Contact Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on LinkedIn Active Motif on Facebook Email: podcast@activemotif.com

Proved the great antitumoral potential of a compound derived from olives   University of Granada (Spain), March 8, 2022   Researchers from the University of Granada (UGR), in collaboration with the universities of Barcelona and Jaen, have brought to light the antitumoral nature of maslinic acid (a compound derived from olives) in Caco-2 p53-deficient colon adenocarcinoma cells in the short term. Maslinic acid (MA) is a natural triterpene found in high concentrations in the waxy skin of olives. The results of this research, recently published in the renowned PloS ONE magazine, show without a doubt how maslinic acid is capable of early inducing the extrinsic cellular death pathway in Caco-2 cells that don't express protein p53 (known by its pro-apoptotic capacity). In previous works, professor Lupiáñez Cara's research team had reported that maslinic acid induces apoptotic cell death via the mitochondrial apoptotic pathway in cancer cell lines.   (NEXT)   Study finds that Nordic diet lowers cholesterol and blood sugar, even if you don't lose weight   University of Copenhagen, March 8, 2022   A healthy Nordic diet can prevent a range of diseases. Until now, the health benefits that researchers had attributed to a Nordic diet primarily focused on weight loss. But in a new study, University of Copenhagen researchers and their Nordic colleagues found clear evidence that a Nordic diet can lower blood sugar and cholesterol levels even without weight loss. In particular, they point to the composition of dietary fats as a possible explanation for the diet's positive effects. Berries, veggies, fish, and whole grains: These are the main ingredients of the Nordic diet concept that for the past decade, has been recognized as extremely healthy, tasty and sustainable. The diet can prevent obesity and reduce the risk of cardiovascular disease, type 2 diabetes, high blood pressure and high cholesterol. Until now, Nordic diet research has primarily been linked to the diet's positive health effect following weight loss. But a new analysis conducted by University of Copenhagen researchers, among others, makes it clear that a Nordic diet has positive health benefits, regardless of whether one loses weight or not.   (NEXT)   Study finds distinct biological ages across individuals' various organs and systems   Beijing Genomics Institute and Lobachevsky State University (Russia), March 8, 2022   It's common to say that someone looks either younger or older than their chronological age, but aging is more than skin deep. Our various organs and systems may have different ages, at least from a biological perspective. In a study published March 8 in the journal Cell Reports, an international team of investigators used biomarkers, statistical modeling, and other techniques to develop tools for measuring the biological ages of various organ systems. Based on their findings, the researchers report that there are multiple "clocks" within the body that vary widely based on factors including genetics and lifestyle in each individual. Most human aging studies have been conducted on older populations and in cohorts with a high incidence of chronic diseases because the aging process in young healthy adults is largely unknown and some studies have suggested that age-related changes could be detected in people as young as their 20s, we decided to focus on this age range."   (NEXT)   Treating heart attacks with a medium chain fatty acid   University of Michigan, March 8, 2022   A medium-chain fatty acid might one day help protect against heart attack injuries. In this publication, we target the interplay between energy metabolism and epigenetics mediated by the medium chain fatty acid 8C." Wang and colleagues were able to protect against heart attack injury in rat models with octanoic acid, an eight carbon (8C) medium chain fatty acid, as well as a few other metabolites. Those fatty acids produced acetyl-CoA, a building block for energy metabolism, which a stressed heart desperately needs. The idea is that a physician would administer this therapy to a person once they arrive at the hospital after having a heart attack, to reduce further injury and improve heart function during recovery, he says.   (NEXT)   Stress damages the movement centers in the brain   University of Bonn (Germany), March 8, 2022   Stress seems to have a negative effect on the learning of movements—at least in mice. This is the conclusion of a recent study at the University of Bonn. According to the study, the neurons of rodents lose some of their contacts with other neurons after stress. The animals also developed motor deficits. The results may be useful for earlier diagnosis and improved therapy of stress-related diseases such as depression. They also document that stress leaves traces in the brain—possibly permanent ones. The study appeared in the journal Translational Psychiatry.Chronically stressed people often show abnormalities in their motor skills, such as poorer fine motor control. The researchers came across a conspicuous feature: after the stressful situation, the neurons studied lost some of their synapses—these are the contacts to other nerve cells. During learning processes, new synapses are usually formed or existing ones are strengthened. Instead, the stressed rodents lost up to 15 percent of their contacts.   (OTHER NEWS)   Lead exposure in last century shrunk IQ scores of half of Americans   Duke University, March 7, 2022   In 1923, lead was first added to gasoline to help keep car engines healthy. However, automotive health came at the great expense of our own well-being. A new study calculates that exposure to car exhaust from leaded gas during childhood stole a collective 824 million IQ points from more than 170 million Americans alive today, about half the population of the United States. The findings suggest that Americans born before 1996 may now be at greater risk for lead-related health problems, such as faster aging of the brain. Leaded gas for cars was banned in the U.S. in 1996, but the researchers say that anyone born before the end of that era, and especially those at the peak of its use in the 1960s and 1970s, had concerningly high lead exposures as children. The team's paper appeared the week of March 7 in the journal Proceedings of the National Academy of Sciences. Lead is able to reach the bloodstream once it's inhaled as dust, or ingested, or consumed in water. In the bloodstream, it's able to pass into the brain through the blood-brain barrier, which is quite good at keeping a lot of toxicants and pathogens out of the brain, but not all of them. One major way lead used to invade bloodstreams was through automotive exhaust.   (NEXT)   Amazon rainforest is losing resilience: New evidence from satellite data analysis   Potsdam Institute for Climate Impact Research (Germany), March 7, 2022   The Amazon rainforest is likely losing resilience, data analysis from high-resolution satellite images suggests. This is due to stress from a combination of logging and burning – the influence of human-caused climate change is not clearly determinable so far, but will likely matter greatly in the future. For about three quarters of the forest, the ability to recover from perturbation has been decreasing since the early 2000s, which the scientists see as a warning sign. The new evidence is derived from advanced statistical analysis of satellite data of changes in vegetation biomass and productivity. “Reduced resilience – the ability to recover from perturbations like droughts or fires – can mean an increased risk of dieback of the Amazon rainforest. The Amazon rainforest is a home to a unique host of biodiversity, strongly influences rainfall all over South America by way of its enormous evapotranspiration, and stores huge amounts of carbon that could be released as greenhouse gases in the case of even partial dieback, in turn contributing to further global warming. This is why the rainforest is of global relevance. The Amazon is considered a potential tipping element in the Earth system and a number of studies revealed its vulnerability.

Stand Up is a daily podcast. I book,host,edit, post and promote new episodes with brilliant guests every week day. Please subscribe now for as little as 5$ and gain access to a community of almost 800 awesome, curious, kind, funny, brilliant, generous soul. sign up now and join us every Thursday night for a virtual happy hour. Now on to today's show notes Dr. Rasmussen is a virologist studying host responses to infection by combining classical virology with modern systems biology approaches. Her research objectives are to identify host response signatures predictive of infection severity or disease outcome and host pathways to target drug development or repurposing. She is particularly interested in viruses that are highly pathogenic, newly emergent or likely to emerge because of climate change, land development, or ecological disruption. Currently she is focused on SARS-CoV-2, as well as other emerging pathogens with the potential to profoundly impact global health, such as Ebola virus, MERS-CoV, influenza virus, and hemorrhagic fever viruses. She works closely with other faculty and affiliates within the GHSS on the Viral Emergence Research Initiative (the VERENA Consortium), where she leads the core virology team. Dr. Rasmussen has employed uses in vitro systems, animal models, and clinical specimens to study the relationship between host response and pathogenesis. She previously developed a  model of Ebola virus disease in a genetically diverse panel of mice, the Collaborative Cross (CC), leveraging the diversity of CC mouse disease phenotypes to study genetic and transcriptomic factors underlying disease severity in humans. She has applied this model to developing predictive signatures of disease outcome and infection and identify novel drug targets. She is currently evaluating CC mouse models towards investigation of sex-specific host responses to viral infection, as well as to investigate disease presentation in other viruses that pose a major threat to global public health, including SARS-CoV-2. Ultimately, these host response profiles can be used for translational or biodefense applications, such as diagnosing infection, predicting disease severity, informing vaccine design, and developing or repurposing host-targeted drugs to impair virus replication or reverse pathology.  Dr. Rasmussen has published numerous original research articles in the peer-reviewed literature and serves on the editorial board of Cell Reports and mSphere. In addition to her scientific work, she believes that engagement of the public is essential to successful public health initiatives and is an active and outspoken science communicator. She has written for Forbes, Foreign Affairs, Slate, the Guardian, and Leapsmag, and appeared many times in media outlets including the New York Times, the Washington Post, National Public Radio, ABC, NBC, CNN, CBC, and BBC. She is also an advocate for equitable and inclusive science, and serves on the NIH Advisory Committee to the Director's Working Group on Changing the Culture to End Sexual Harassment. Check out all things Jon Carroll Follow and Support Pete Coe Pete on YouTube Pete on Twitter Pete On Instagram Pete Personal FB page  

Magnesium is essential for the immune system, including in the fight against cancer University of Basel (Switzerland), January 19, 2022 Previous studies have shown that cancerous growths spread faster in the bodies of mice when the animals received a low-magnesium diet – and that their defense against flu viruses was also impaired. However, there has so far been little research into how exactly this mineral affects the immune system. Now, researchers have discovered that T cells can eliminate abnormal or infected cells efficiently only in a magnesium-rich environment. Specifically, magnesium is important for the function of a T cell surface protein called LFA-1. (NEXT) More lycopene linked to longer lives for people with metabolic syndrome University of Nebraska Medical Center, January 16, 2022 Higher blood levels of lycopene may reduce the risk of mortality in people with metabolic syndrome, says a new study from the University of Nebraska Medical Center. Lycopene is an antioxidant that is present in red- and pink-colored fruits and vegetables. As well as being used as a food coloring, it is also used in supplements and functional foods and beverages. New data published in Nutrition Research suggests that higher serum levels of lycopene were associated with greater survival times for people with metabolic syndrome, compared to low serum levels. (NEXT) Too much sugar during adolescence may alter brain's reward circuits European Journal of Neuroscience, January 19, 2022 A new study in rats may provide significant insights into the long-term impacts of over-consumption of sugary foods during adolescence. The study shows that the enjoyment of such foods later in adulthood is reduced in those who over-consumed early in life. Investigators found that this decrease in reward relates to reduced activity in one of the key hubs of the brain's reward circuitry, called the nucleus accumbens. Such long-lasting alterations could have important implications for reward-related disorders such as substance abuse or eating disorders. (NEXT) Unveiled the epigenetic mechanism by which vitamin D modulates the tolerance of the immune system Josep Carreras Leukaemia Research Institute (Germany), January 19, 2022 In autoimmunity, the mechanisms that guarantee that our defense system does not attack our own body - tolerance to oneself - does not work properly. Multiple sclerosis, which affects one in every 1,000 people in Spain, is a serious autoimmune disease in which the immune system attacks the myelin sheath of some types of neurons, causing progressive neurological disability. Dr. Esteban Ballestar, leader of the Epigenetics and immune diseases group at the Josep Carrreras Leukaemia Research Institute, and Dr. Eva Martínez-Cáceres, leader of the Immunopathology group at the IGTP-Hospital Germans Trias i Pujol, have recently published in the prestigious journal Cell Reports the mechanism by which vitamin D activates the tolerance program of dendritic cells. (NEXT) Study links poor sleep in seniors to more severe arteriosclerosis University of Toronto, January 19, 2022 Poor sleep quality in older people is associated with more severe arteriosclerosis in the brain as well as a greater burden of oxygen-starved tissue (infarcts) in the brain, both of which can contribute to the risk of stroke and cognitive impairment, according to the newest findings reported in the American Heart Association's journal Stroke. The relationship between cardiovascular disease and so-called "fragmented" sleep has been studied in the past, but this is the first study to look specifically for an association between sleep fragmentation and detailed microscopic measures of blood vessel damage and infarcts in autopsied brain tissue from the same individuals. Fragmented sleep occurs when sleep is interrupted by repeated awakenings or arousals. In this study, sleep was disrupted on average almost seven times per hour. Researchers found that greater sleep fragmentation was associated with 27 percent higher odds of having severe arteriosclerosis. Moreover, for each additional two arousals during one hour of sleep, researchers reported a 30 percent increase in the odds that subjects had visible signs of oxygen deprivation in their brain. (OTHER NEWS) America's New Class War Chris Hedges, January 18, 2022 There is one last hope for the United States. It does not lie in the ballot box. It lies in the union organizing and strikes by workers at Amazon, Starbucks, Uber, Lyft, John Deere, Kellogg, the Special Metals plant in Huntington, West Virginia, owned by Berkshire Hathaway, the Northwest Carpenters Union, Kroger, teachers in Chicago, West Virginia, Oklahoma and Arizona, fast-food workers, hundreds of nurses in Worcester, Massachusetts, and the members of the International Alliance of Theatrical Stage Employees. Organized workers, often defying their timid union leadership, are on the march across the United States. Over four million workers, about 3% of the work force, mostly from accommodation and food services, healthcare and social assistance, transportation, housing, and utilities have walked away from jobs, rejecting poor pay along with punishing and risky working conditions. There is a growing consensus – 68% in a recent Gallup poll with that number climbing to 77% of those between the ages of 18 and 34 – that the only way left to alter the balance of power and force concessions from the ruling capitalist class is to mobilize and strike, although only 9% of the U.S. work force is unionized. Forget the woke Democrats. This is a class war. The Democratic Party will not push through the kind of radical New Deal reforms that in the 1930s staved off fascism and communism. Its empty political theater, which stretches back to the Clinton administration, was on full display in Atlanta when Biden called for revoking the filibuster to pass the Freedom to Vote Act and the John Lewis Voting Rights Advancement Act, knowing that his chances of success are zero. Georgia Democratic gubernatorial candidate Stacey Abrams, along with several of the state's voting rights groups, boycotted the event in a very public rebuke. They were acutely aware of Biden's cynical ploy. When the Democrats were in the minority, they clung to the filibuster like a life raft. Then Sen. Barack Obama, along with other Democrats, campaigned for it to remain in place. And a few days ago, the Democratic leadership employed the filibuster to block legislation proposed by Sen. Ted Cruz. The Democrats have been full partners in the dismantling of our democracy, refusing to banish dark and corporate money from the electoral process and governing, as Obama did, through presidential executive actions, agency “guidance,” notices and other regulatory dark matter that bypass Congress. The Democrats, who helped launch and perpetuate our endless wars, were also co-architects of trade deals such as NAFTA, expanded surveillance of citizens, militarized police, the largest prison system in the world and a raft of anti-terrorism laws such as Special Administrative Measures (SAMs) that abolish nearly all rights, including due process and attorney-client privilege, to allow suspects to be convicted and imprisoned with secret evidence they and their lawyers are not permitted to see. The squandering of staggering resources to the military — $777.7 billion a year — passed in the Senate with an 89-10 vote and in the House of Representatives with a 363-70 vote, coupled with the $80 billion spent annually on the intelligence agencies has made the military and the intelligence services, many run by private contractors such as Booz Allen Hamilton, nearly omnipotent. The Democrats long ago walked out on workers and unions. The Democratic governor of Maine, Janet Mills, for example, killed a bill a few days ago that would have allowed farm workers in the state to unionize. On all the major structural issues there is no difference between the Republicans and the Democrats. The longer the Democratic Party does not deliver real reforms to ameliorate the economic hardship, exacerbated by soaring inflation rates, the more it feeds the frustration of many of its supporters, widespread apathy (there are 80 million eligible voters, a third of the electorate, who do not cast ballots) and the hatred of the “liberal” elites stoked by Donald Trump's cultish Republican Party. Its signature infrastructure package, Build Back Better, when you read the fine print, is yet another infusion of billions of government money into corporate bank accounts. This should not surprise anyone, given who funds and controls the Democratic Party. The rapacious pillage by the elites, many of whom bankroll the Democratic Party, has accelerated since the financial crash of 2008 and the pandemic. Wall Street banks recorded record profits for 2021. As the Financial Times noted, they milked the underwriting fees from Fed-based borrowing and profited from mergers and acquisitions. They have pumped their profits, fueled by roughly $5 trillion in Fed spending since the beginning of the pandemic, as Matt Taibbi points out, into massive pay bonuses and stock buybacks. “The bulk of this new wealth—most—is being converted into compensation for a handful of executives,” Taibbi writes. “Buybacks have also been rampant in defense, pharmaceuticals, and oil & gas, all of which also just finished their second straight year of record, skyrocketing profits. We're now up to about 745 billionaires in the U.S., who've collectively seen their net worth grow about $2.1 trillion to $5 trillion since March 2020, with almost all that wealth increase tied to the Fed's ballooning balance sheet.” Kroger is typical. The corporation, which operates some 2,800 stores under different brands, including Baker's, City Market, Dillons, Food 4 Less, Foods Co., Fred Meyer, Fry's, Gerbes, Jay C Food Store, King Soopers, Mariano's, Metro Market, Pay-Less Super Markets, Pick'n Save, QFC, Ralphs, Ruler and Smith's Food and Drug, earned $4.1 billion in profits in 2020. By the end of the third quarter of 2021, it had $2.28 billion in cash, an increase of $399 million in the first quarter of 2020. Kroger CEO Rodney McMullen made over $22 million, nearly doubling the $12 million he made in 2018. This is over 900 times the salary of the average Kroger worker. Kroger in the first three quarters of 2021 also spent an estimated $1.3 billion on stock buybacks. Class struggle defines most of human history. Marx got this right. It is not a new story. The rich, throughout history, have found ways to subjugate and re-subjugate the masses. And the masses, throughout history, have cyclically awoken to throw off their chains. (NEXT) Was Peter Daszak Working For The Central Intelligence Agency? Kanekoa, January 18, 2022 “We found other coronaviruses in bats, a whole host of them, some of them looked very similar to SARS. So we sequenced the spike protein: the protein that attaches to cells. Then we… Well, I didn't do this work, but my colleagues in China did the work. You create pseudo particles, you insert the spike proteins from those viruses, see if they bind to human cells. At each step of this, you move closer and closer to this virus could really become pathogenic in people. You end up with a small number of viruses that really do look like killers." This statement was said by EcoHealth Alliance President Peter Daszak at a 2016 forum discussing “emerging infectious diseases and the next pandemic”. Daszak, who received more than $118 million in grants and contracts from federal agencies, including $53 million from USAID, $42 million from DOD, and $15 million from HHS, appeared to boast about the manipulation of “killer” SARS-like coronaviruses carried out by his “colleagues in China” at the now infamous Wuhan Institute of Virology. According to investigative research done by independent-journalist Sam Husseini and The Intercept, much of the money awarded to EcoHealth Alliance did not focus on health or ecology, but rather on biowarfare, bioterrorism, and other dangerous uses of deadly pathogens. EcoHealth Alliance received the majority of its funding from the United States Agency for International Development (USAID), a State Department subsidiary that serves as a frequent cover for the Central Intelligence Agency (CIA). Their second largest source of funding was from the Defense Threat Reduction Agency (DTRA), which is a branch of the Department of Defense (DOD) which states it is tasked to “counter and deter weapons of mass destruction and improvised threat networks.” The United States Agency for International Development (USAID) has a long history of acting as a contract vehicle for various CIA covert activities. With an annual budget of over $27 billion and operations in over 100 countries, one former USAID director, John Gilligan, once admitted it was “infiltrated from top to bottom with CIA people.” Gilligan explained that “the idea was to plant operatives in every kind of activity we had overseas; government, volunteer, religious, every kind.” From 2009 to 2019, USAID partnered with EcoHealth Alliance on their PREDICT program which identified over 1,200 new viruses, including over 160 coronavirus strains; trained roughly 5,000 people around the world to identify new diseases; and improved or developed 60 research laboratories. What better way for the CIA to collect intelligence on the world's biological warfare capabilities? Dr. Andrew Huff received his Ph.D. in Environmental Health specializing in emerging diseases before becoming an Associate Vice President at EcoHealth Alliance, where he developed novel methods of bio-surveillance, data analytics, and visualization for disease detection. On January 12, 2022, Dr. Andrew Huff issued a public statement (on Twitter) in which he claimed, Peter Daszak, the President of EcoHealth Alliance, told him that he was working for the CIA. Dr. Huff continued, “…I wouldn't be surprised if the CIA / IC community orchestrated the COVID coverup acting as an intermediary between Fauci, Collins, Daszak, Baric, and many others. At best, it was the biggest criminal conspiracy in US history by bureaucrats or political appointees.” In February 2020, Daszak told University of North Carolina coronavirus researcher Dr. Ralph Baric that they should not sign the statement condemning the lab-leak theory so that it seems more independent and credible. “You, me and him should not sign this statement, so it has some distance from us and therefore doesn't work in a counterproductive way,” Daszak wrote. More unredacted emails have revealed that while these scientists held the private belief that the lab release was the most likely scenario, they still worked to seed the natural origin narrative for the public through the papers published in Nature Medicineand The Lancet. If Dr. Andrew Huff is telling the truth, Fauci, Collins, and Daszak might be covering up the lab origin not only for themselves, but also for the Central Intelligence Agency, the Department of Defense, and the U.S. Government.

In this episode of the Epigenetics Podcast, we caught up with Jane Mellor from the University of Oxford to talk about her work on H3K4me3, SET proteins, Isw1 and their role in transcription. Since the beginning of the century, Jane Mellor and her team have focused on H3K4 trimethylation and the factors that influence this mark. They discovered that H3K4me3 is an almost universal mark of the first nucleosome in every transcribed unit and all organisms. She could subsequently, together with the Kouzarides lab, identify SetD1, the enzyme that is responsible for writing this modification. Later on, the team characterized Isw1, a chromatin remodeler which “reads” H3K4me3. More recently the lab focuses on how the polymerase transcribes throughout the first nucleosomes of the transcribed region at the +2 nucleosome, with the help of Spt4.   References Santos-Rosa, H., Schneider, R., Bannister, A. J., Sherriff, J., Bernstein, B. E., Emre, N. C. T., Schreiber, S. L., Mellor, J., & Kouzarides, T. (2002). Active genes are tri-methylated at K4 of histone H3. Nature, 419(6905), 407–411. https://doi.org/10.1038/nature01080 Morillon, A., O'Sullivan, J., Azad, A., Proudfoot, N., & Mellor, J. (2003). Regulation of Elongating RNA Polymerase II by Forkhead Transcription Factors in Yeast. Science, 300(5618), 492–495. https://doi.org/10.1126/science.1081379 Morillon, A., Karabetsou, N., O'Sullivan, J., Kent, N., Proudfoot, N., & Mellor, J. (2003). Isw1 Chromatin Remodeling ATPase Coordinates Transcription Elongation and Termination by RNA Polymerase II. Cell, 115(4), 425–435. https://doi.org/10.1016/S0092-8674(03)00880-8 Uzun, Ü., Brown, T., Fischl, H., Angel, A., & Mellor, J. (2021). Spt4 facilitates the movement of RNA polymerase II through the +2 nucleosomal barrier. Cell Reports, 36(13), 109755. https://doi.org/10.1016/j.celrep.2021.109755   Related Episodes Effects of Non-Enzymatic Covalent Histone Modifications on Chromatin (Yael David) Nutriepigenetics: The Effects of Diet on Behavior (Monica Dus) Epigenetic Origins Of Heterogeneity And Disease (Andrew Pospisilik)   Contact Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on LinkedIn Active Motif on Facebook Email: podcast@activemotif.com

Hearing and listening... is there a difference? I am sure that we have all been guilty of letting our minds drift out of a conversation before realising and immediately trying to tune back in. New research published in Cell Reports describes how brain activity varies during listening and hearing and how this work sheds light on neural pathways linked to attention. Katie King spoke with author Tania Barkat to find out the difference between hearing and listening... Like this podcast? Please help us by supporting the Naked Scientists

In this episode of the Epigenetics Podcast, we caught up with Jane Skok from New York University School of Medicine to talk about her work on spatio-temporal alterations in chromosome dynamics. Studies demonstrating that nuclear organization and long-range chromatin interactions play essential roles in gene regulation have been the focus of the Skok Lab, where the team has played a leading role. Their initial studies focused on lymphocyte development and the control of V(D)J recombination, a key part of generating the diverse repertoire of B-cell antibodies and T-cell receptors. The Skok Lab was among the first to demonstrate the possibility of chromatin forming dynamic loops which lead to the formation of reversible intra-locus loops in the immunoglobulin and T-cell receptor loci and to a profound impact on the ability of B and T cells to generate receptor diversity.   References Roldán, E., Fuxa, M., Chong, W., Martinez, D., Novatchkova, M., Busslinger, M., & Skok, J. A. (2005). Locus “decontraction” and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavy-chain gene. Nature Immunology, 6(1), 31–41. https://doi.org/10.1038/ni1150 Skok, J. A. (2014). Taking a break from the lab: Can it really be done? Trends in Cell Biology, 24(12), 725–726. https://doi.org/10.1016/j.tcb.2014.09.002 Proudhon, C., Snetkova, V., Raviram, R., Lobry, C., Badri, S., Jiang, T., Hao, B., Trimarchi, T., Kluger, Y., Aifantis, I., Bonneau, R., & Skok, J. A. (2016). Active and Inactive Enhancers Cooperate to Exert Localized and Long-Range Control of Gene Regulation. Cell Reports, 15(10), 2159–2169. https://doi.org/10.1016/j.celrep.2016.04.087 Lhoumaud, P., Sethia, G., Izzo, F., Sakellaropoulos, T., Snetkova, V., Vidal, S., Badri, S., Cornwell, M., Di Giammartino, D. C., Kim, K.-T., Apostolou, E., Stadtfeld, M., Landau, D. A., & Skok, J. (2019). EpiMethylTag: Simultaneous detection of ATAC-seq or ChIP-seq signals with DNA methylation. Genome Biology, 20(1), 248. https://doi.org/10.1186/s13059-019-1853-6 Nishana, M., Ha, C., Rodriguez-Hernaez, J., Ranjbaran, A., Chio, E., Nora, E. P., Badri, S. B., Kloetgen, A., Bruneau, B. G., Tsirigos, A., & Skok, J. A. (2020). Defining the relative and combined contribution of CTCF and CTCFL to genomic regulation. Genome Biology, 21(1), 108. https://doi.org/10.1186/s13059-020-02024-0   Related Episodes Identification of Functional Elements in the Genome (Bing Ren) Spatial Organization of the Human Genome (Wendy Bickmore) Chromatin Organization (Susan Gasser)   Contact Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on LinkedIn Active Motif on Facebook Email: podcast@activemotif.com

Un eccessivo consumo di sale può influenzare negativamente non solo il cuore, ma anche alcune aree del cervello. A dirlo uno studio dei ricercatori dell’Università Statale della Georgia pubblicato sulla rivista Cell Reports che commentiamo a Obiettivo Salute con il prof. Piero Barbanti, neurologo dell'Università Istituto scientifico San Raffaele di Roma

Police are hunting thieves who stole more than 40 exclusive bottles of wine from a famous Spanish restaurant hotel including one worth an estimated £262,000. The Chateau d'Yquem 1806, bought by the owners in an auction more than 20 years ago at Christie's London, was the most valuable of the wines taken. A man in Murcia was shocked to receive his monthly telephone bill showing a total of €19,500. The bill was eventually cancelled by the telephone company after a consumer organisation got involved in the dispute. The first fine for charging tenants a rent price above the limit set out by Catalan law has been handed out in Barcelona. Esteve and two other colleagues rented an apartment in Barcelona last December, paying €1,200 per month. That is until they discovered, with the help of the Sindicat de Llogateres (Tenant Union), that the price was €250 higher than the Catalan income containment law allows. A research group from the Severo Ochoa Molecular Biology Centre (CBMSO) has revealed the results of a study they conducted. It was published in the specialist publication, Cell Reports. This joint study by the Autonomous University of Madrid (UAM), and the Higher Council for Scientific Research (CSIC), has shown the therapeutic potential of a mouse parvovirus to infect and destroy human glioblastoma stem cells. Pilar Mateo, a Spanish researcher from the University of Valencia, with a PhD in Chemistry, has come up with a very effective form of prevention to control and eliminate insects – insecticidal paint! Throughout the world, mainly in tropical and equatorial regions, insect-borne diseases are a very serious problem. They cost the lives of hundreds of thousands of people every year, and at this time, there are no effective vaccines or treatments for most of them.The ongoing coronavirus pandemic has prompted many people to be more concerned about their health and diet. 86 per cent of Spaniards have admitted to this. Spaniards are far more concerned about their diet since the pandemic began than Germans, the British, the French and other nationalities.A staggering 63 per cent of Spaniards are aiming to “eat healthier” than they did before the pandemic began. Return of the handshake. The handshake is set to return after being “banned” early on in the coronavirus pandemic. Prime Minister Boris Johnson tested positive for the coronavirus only three weeks after having bragged about shaking hands “with everyone” at a hospital.Throughout the pandemic, many people have focused on hand hygiene. For many people, it is their natural instinct to shake someone's hand when they meet. For months now people have avoided handshakes. It looks like now though the handshake is set to make its return.

Police are hunting thieves who stole more than 40 exclusive bottles of wine from a famous Spanish restaurant hotel including one worth an estimated £262,000. The Chateau d'Yquem 1806, bought by the owners in an auction more than 20 years ago at Christie's London, was the most valuable of the wines taken. A man in Murcia was shocked to receive his monthly telephone bill showing a total of €19,500. The bill was eventually cancelled by the telephone company after a consumer organisation got involved in the dispute. The first fine for charging tenants a rent price above the limit set out by Catalan law has been handed out in Barcelona. Esteve and two other colleagues rented an apartment in Barcelona last December, paying €1,200 per month. That is until they discovered, with the help of the Sindicat de Llogateres (Tenant Union), that the price was €250 higher than the Catalan income containment law allows. A research group from the Severo Ochoa Molecular Biology Centre (CBMSO) has revealed the results of a study they conducted. It was published in the specialist publication, Cell Reports. This joint study by the Autonomous University of Madrid (UAM), and the Higher Council for Scientific Research (CSIC), has shown the therapeutic potential of a mouse parvovirus to infect and destroy human glioblastoma stem cells. Pilar Mateo, a Spanish researcher from the University of Valencia, with a PhD in Chemistry, has come up with a very effective form of prevention to control and eliminate insects – insecticidal paint! Throughout the world, mainly in tropical and equatorial regions, insect-borne diseases are a very serious problem. They cost the lives of hundreds of thousands of people every year, and at this time, there are no effective vaccines or treatments for most of them. The ongoing coronavirus pandemic has prompted many people to be more concerned about their health and diet. 86 per cent of Spaniards have admitted to this. Spaniards are far more concerned about their diet since the pandemic began than Germans, the British, the French and other nationalities. A staggering 63 per cent of Spaniards are aiming to “eat healthier” than they did before the pandemic began. Return of the handshake. The handshake is set to return after being “banned” early on in the coronavirus pandemic. Prime Minister Boris Johnson tested positive for the coronavirus only three weeks after having bragged about shaking hands “with everyone” at a hospital.

In this episode of the Epigenetics Podcast, we caught up with Camila dos Santos from Cold Spring Harbor Laboratories to talk about her work on enhancers and chromatin remodeling in mammary gland development. The lab of Camila dos Santos focuses on epigenetic regulation of normal and malignant mammary gland development. After puberty, the next significant phase in mammary gland development occurs in pregnancy, including changes in cellular function, and tissue reorganization. A different and as significant change in mammary glands occurs in the development breast cancer. Camila dos Santos and her lab were recently able to show that the reaction of mammary glands to a second pregnancy is different than to a first one, which is accompanied by changes in the DNA methylome of the cells. Furthermore, the lab studies the connection of pregnancy-induced epigenetic changes of chromatin and the risk of cancer development.   References dos Santos, C. O., Rebbeck, C., Rozhkova, E., Valentine, A., Samuels, A., Kadiri, L. R., Osten, P., Harris, E. Y., Uren, P. J., Smith, A. D., & Hannon, G. J. (2013). Molecular hierarchy of mammary differentiation yields refined markers of mammary stem cells. Proceedings of the National Academy of Sciences, 110(18), 7123–7130. https://doi.org/10.1073/pnas.1303919110 dos Santos, C. O., Dolzhenko, E., Hodges, E., Smith, A. D., & Hannon, G. J. (2015). An Epigenetic Memory of Pregnancy in the Mouse Mammary Gland. Cell Reports, 11(7), 1102–1109. https://doi.org/10.1016/j.celrep.2015.04.015 Feigman, M. J., Moss, M. A., Chen, C., Cyrill, S. L., Ciccone, M. F., Trousdell, M. C., Yang, S.-T., Frey, W. D., Wilkinson, J. E., & dos Santos, C. O. (2020). Pregnancy reprograms the epigenome of mammary epithelial cells and blocks the development of premalignant lesions. Nature Communications, 11(1), 2649. https://doi.org/10.1038/s41467-020-16479-z   Related Episodes Ultraconserved Enhancers and Enhancer Redundancy (Diane Dickel) Epigenetic Regulation of Stem Cell Self-Renewal and Differentiation (Peggy Goodell) Cancer and Epigenetics (David Jones)   Contact Active Motif on Twitter Epigenetics Podcast on Twitter Active Motif on LinkedIn Active Motif on Facebook Email: podcast@activemotif.com

Learn about how people synchronize their heart rates when listening to a story; and vampire bats meeting up for meals. You're invited to join Cody Gough and Ashley Hamer for a special live stream celebration to commemorate the release of Curiosity Daily's 1,000th episode next week! Register for free here: https://www.eventbrite.com/e/curiosity-dailys-1000th-episode-celebration-tickets-191163133077  People synchronize their heart rates when listening to a story, even when they're in different places by Grant Currin  When Choirs Sing, Many Hearts Beat As One. (2013, July 10). NPR.org. https://www.npr.org/sections/health-shots/2013/07/09/200390454/when-choirs-sing-many-hearts-beat-as-one  ‌UCL. (2017, November 17). Audience members' hearts beat together at the theatre. UCL Psychology and Language Sciences. https://www.ucl.ac.uk/pals/news/2017/nov/audience-members-hearts-beat-together-theatre  Pérez, P., Madsen, J., Banellis, L., Türker, B., Raimondo, F., Perlbarg, V., Valente, M., Niérat, M.-C., Puybasset, L., Naccache, L., Similowski, T., Cruse, D., Parra, L. C., & Sitt, J. D. (2021). Conscious processing of narrative stimuli synchronizes heart rate between individuals. Cell Reports, 36(11), 109692. https://doi.org/10.1016/j.celrep.2021.109692  Tibi Puiu. (2021, September 14). Our heart rates synchronize when closely listening to the same stories. ZME Science; ZME Science. https://www.zmescience.com/medicine/mind-and-brain/our-heart-rates-synchronize-when-closely-listening-to-the-same-stories/  ‌The Project Gutenberg E-text of Twenty Thousand Leagues Under the Sea (slightly abridged), by Jules Verne. (2016). Gutenberg.org. https://www.gutenberg.org/files/164/164-h/164-h.htm  Vampire bats meet up with friends for lunch by Grant Currin Vampire bats may coordinate with “friends” over a bite to eat. (2021, September 23). EurekAlert! https://www.eurekalert.org/news-releases/928884  Ripperger, S. P., & Carter, G. G. (2021). Social foraging in vampire bats is predicted by long-term cooperative relationships. PLOS Biology, 19(9), e3001366. https://doi.org/10.1371/journal.pbio.3001366  ‌Spivack, E. (2021, September 28). Vampire bats rendezvous with their friends when dining out. Popular Science. https://www.popsci.com/animals/vampire-bats-eat-together/  Vampire bat adoption episode: https://www.curiositydaily.com/vampire-bats-adopt-babies-too/  Follow Curiosity Daily on your favorite podcast app to learn something new every day withCody Gough andAshley Hamer. Still curious? Get exclusive science shows, nature documentaries, and more real-life entertainment on discovery+! Go to https://discoveryplus.com/curiosity to start your 7-day free trial. discovery+ is currently only available for US subscribers. See omnystudio.com/listener for privacy information.

生活经验告诉我们，劳逸结合很重要，适当放松能让人以更好的状态投入学习、工作。近日发表的一项新研究还发现，在清醒的休息状态，大脑活动能够以 20 倍的速度“回放”刚刚学过的动作序列，这个过程可能对记忆巩固非常重要。该研究 6 月 8 日在《细胞报告》（Cell Reports）发表。

生活经验告诉我们，劳逸结合很重要，适当放松能让人以更好的状态投入学习、工作。近日发表的一项新研究还发现，在清醒的休息状态，大脑活动能够以 20 倍的速度“回放”刚刚学过的动作序列，这个过程可能对记忆巩固非常重要。该研究 6 月 8 日在《细胞报告》（Cell Reports）发表。

生活经验告诉我们，劳逸结合很重要，适当放松能让人以更好的状态投入学习、工作。近日发表的一项新研究还发现，在清醒的休息状态，大脑活动能够以 20 倍的速度“回放”刚刚学过的动作序列，这个过程可能对记忆巩固非常重要。该研究 6 月 8 日在《细胞报告》（Cell Reports）发表。

The COVID-19 pandemic continues to worsen by most objective measures. We're breaking records for cases, deaths, and hospitalizations on a regular basis, and many of our hospitals are operating at or near capacity. Further complicating the situation, scientists are tracking the “UK variant” that is more transmissible, and our vaccine distribution has fallen well short of expectations. Emergent problems in a deepening crisis, of course, make us vulnerable to knee-jerk reactions that distract us from the known path to getting the pandemic under control. On this episode, we're talking with virologist Dr. Angela Rasmussen about these emergent issues. She helps us to understand what they mean and puts them in context by pointing out the good things that are happening too. First and foremost, the vaccines are more efficacious than expected (i.e., around 95%). Second, the “UK variant”, while worrisome, has not evolved in any way that makes existing, non-pharmaceutical interventions less effective (e.g., masks, social-distancing, avoid crowds, clean high-touch surfaces, etc.).   The UK Strain Dr. Rasmussen tells us that the B.1.1.7 strain, better known as the “UK variant”, is worrisome. However, travel bans aren't an effective response to the new COVID-19 variant. The new strain was detected first in the UK, but that is likely because the UK is doing more genomic surveillance than most countries. They found it because they were looking, but it could have originated elsewhere. Dr. Rasmussen explains “travel bans are only really effective when you can guarantee that you would not be exporting the virus from one place to another”. And since we don't know for sure where the variant first-evolved, or where it has spread to, there is simply no way to design an effective travel ban. We also discuss:   How viruses mutate and evolve Why the new variant is believed to be more transmissible Potential behavior components that may have impacted the numbers That the known, non-pharmaceutical interventions work against every variant of SARS coronavirus (i.e., the virus hasn't mutated in a way that makes our masks, social-distancing, etc. less effective). We should double-down on those now.   Communicating Science to the Public We continue to examine communications lessons that can be learned from the COVID-19 pandemic. Dr Rasmussen tells us that scientists and media tend to make one of two mistakes:   They default to the worst case scenario and communicate in a very reactionary way They oversimplify things, trying to get the public to understand and comply with certain behaviors   Both approaches create gaps in understanding and acceptance of our message. To mitigate these issues, Dr. Rasmussen tells us to think about three key things whenever we're communicating science to the public:   Talk openly about what we don't know, and about the nuances, so that people become more comfortable with uncertainty End every message with actionable advice. Tell them what they can and should do right now to protect themselves. Repeat the message over and over. In a constantly evolving environment, we may be tempted to jump from topic to topic. Our messaging should always be grounded in the tried and true (e.g., the non-pharmaceutical interventions discussed earlier)   Vaccine Challenges We're dealing with a triple threat when it comes to the vaccine. First, we have our current distribution problems. There are vaccines available and they are being administered much more slowly than we'd like. Second, there are known supply challenges that could worsen if/when we alleviate the distribution delays. Third, we're dealing with vaccine “hesitancy” and the recent discussions around changing dosing regimens, despite the fact that we have no data to support those changes, might cast further doubt for those on the fence. Dr. Rasmussen shares her thoughts on these high-level issues, and gets into the details of each:   What is causing our distribution problems, and what are the steps that can be taken right now? What do we know about the potential for widespread supply issues, and how are our current efforts to head them off distracting us from the distribution problem we have right now? What will it take to achieve herd immunity and slow, or stop community transmission? Why the vaccine is a medium-to-long-term solution, and the importance of redoubling our efforts on non-pharmaceutical interventions to slow community spread in the near-term How we can use the tried-and-true epidemiological path, in conjunction with vaccination to slow community transmission and get us on the right path in the foreseeable future   Dr. Angela Rasmussen Dr. Rasmussen is a virologist studying host responses to infection by combining classical virology with modern systems biology approaches. Her research objectives are to identify host response signatures predictive of infection severity or disease outcome and host pathways to target drug development or repurposing. She is particularly interested in viruses that are highly pathogenic, newly emergent or likely to emerge because of climate change, land development, or ecological disruption. Currently she is focused on SARS-CoV-2, as well as other emerging pathogens with the potential to profoundly impact global health, such as Ebola virus, MERS-CoV, influenza virus, and hemorrhagic fever viruses. She works closely with other faculty and affiliates within the GHSS on the Viral Emergence Research Initiative (the VERENA Consortium), where she leads the core virology team. Dr. Rasmussen has employed uses in vitro systems, animal models, and clinical specimens to study the relationship between host response and pathogenesis. She previously developed a  model of Ebola virus disease in a genetically diverse panel of mice, the Collaborative Cross (CC), leveraging the diversity of CC mouse disease phenotypes to study genetic and transcriptomic factors underlying disease severity in humans. She has applied this model to developing predictive signatures of disease outcome and infection and identify novel drug targets. She is currently evaluating CC mouse models towards investigation of sex-specific host responses to viral infection, as well as to investigate disease presentation in other viruses that pose a major threat to global public health, including SARS-CoV-2. Ultimately, these host response profiles can be used for translational or biodefense applications, such as diagnosing infection, predicting disease severity, informing vaccine design, and developing or repurposing host-targeted drugs to impair virus replication or reverse pathology.  Dr. Rasmussen has published numerous original research articles in the peer-reviewed literature and serves on the editorial board of Cell Reports and mSphere. In addition to her scientific work, she believes that engagement of the public is essential to successful public health initiatives and is an active and outspoken science communicator. She has written for Forbes, Foreign Affairs, Slate, the Guardian, and Leapsmag, and appeared many times in media outlets including the New York Times, the Washington Post, National Public Radio, ABC, NBC, CNN, CBC, and BBC. She is also an advocate for equitable and inclusive science, and serves on the NIH Advisory Committee to the Director's Working Group on Changing the Culture to End Sexual Harassment.   Email: ar1692@georgetown.edu Web: https://angelarasmussen.org/ Twitter: @angie_rasmussen   Links and Resources   For mRNA vaccines, we should stick to the schedule Travel bans aren't an effective response to the new COVID-19 variant Pizza-sized boxes and paying a premium: Israel's COVID-19 vaccine rollout Canada has secured more vaccine doses per capita than anyone else, but it's been slow to administer them Doug Ford says Ontario will run out of Pfizer COVID-19 vaccines by end of next week

  Vidcast:  https://youtu.be/3DAXea20sSU   Natural sunlight triggers normal fat cell metabolism.  Experimental biologists from Cincinnati Children's Hospital just published a study that explores how light performs this trick in mammals like rats and yes humans.   Fat cells contain light sensitive proteins called opsins.  Light reaches fat cells through our skin, activates opsins that release fatty acids from white fat cells,  and the fatty acids serve as fuel for brown fat cells to produce heat.  If this process fails to occur, disordered fat metabolism can lead to heart disease, stroke, and diabetes.   Indoor lighting won't work, so spend time in sunlight.  UV blocking lotions won't stop the good stuff so do use them to prevent skin cancer.    Nayak et al., 2020, Cell Reports 30, 672–686 January 21, 2020 a 2019 The Authors. https://doi.org/10.1016/j.celrep.2019.12.043   #sunlight #fat #heat #heartdisease #stroke #diabetes  

Learn why some people get colds and others don't. Improve your chances of dodging the common cold bullet. VideoPodcast: https://youtu.be/KSq2867eDAI Valia T. Mihaylova, Yong Kong, Olga Fedorova, Lokesh Sharma, Charles S. Dela Cruz, Anna Marie Pyle, Akiko Iwasaki, Ellen F. Foxman. Regional Differences in Airway Epithelial Cells Reveal Tradeoff between Defense against Oxidative Stress and Defense against Rhinovirus. Cell Reports, September 11, 2018 DOI: 10.1016/j.celrep.2018.08.033

Protein is really important for dieting success, right? Anyone who has interested in the science of dieting knows this, but recent research from Bettina Mittendorfer, Research Associate Professor at Washington University in St. Louis's School of Medicine, and colleagues published in Cell Reports has raised doubts that protein is indeed a wholly-helpful solution. To shed light on this study and its findings, Dan invited Dr. Stephan Guyenet to join humanOS Radio for a conversation. Perhaps no other person has done more in the last few years to help the general public, and even health professionals, understand the true meaning of new research dealing with energy regulation and weight control.