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What if longevity wasn't just about extending lifespan, but expanding the years you live with strength, clarity, and vitality? In this episode, I sit down with Dr. Christopher Keroack, an internist who brings a powerful clinical lens to the science of aging well. Our conversation starts with a question I believe every patient should ask: Are we adding years to life, or adding life to years? Dr. Keroack walks me through how medicine has shifted from simply preventing death to actively preserving vitality, and why the distinction between lifespan and healthspan is now more important than ever. We dive into the 12 hallmarks of aging, mitochondrial health, synolytics for clearing zombie cells, and the emerging role of peptide therapy in longevity. We also explore the practical metrics that matter most — VO2 max, muscle mass, body composition, blood pressure regulation — and how these biomarkers shape the trajectory of aging. What I appreciate about Dr. Keroack's perspective is his balance. He's grounded in internal medicine, understands genetics and environmental triggers, and still champions lifestyle as the foundation of long-term wellness. From hormone optimization to the nuanced use of antibiotics, we cover the strategies and controversies shaping modern longevity medicine. This episode is for anyone who wants to understand the science behind staying youthful and take actionable control of their health trajectory. Key takeaways: Lifespan vs. Healthspan: Dr. Keroack emphasizes the importance of living a longer yet healthier life, integrating longevity with quality daily experiences. Lifestyle Pillars: Integrative habits like deep sleep, nutrition, stress management, and social connectivity are highlighted as fundamental in promoting healthspan. Supplements and Insights: Berberine, NMN, and creatine are identified as pivotal supplements for boosting longevity, alongside strategic exercise for maintaining VO2 max and muscle mass. Role of Peptides: Peptide therapy, including BPC157 and TB4 frag, is discussed as an evolving frontier in personalizing longevity and enhancing recovery from physical stresses. Science and Practicality: With firsthand experiences, Dr. Keroack shares invaluable wisdom, advocating for a balanced approach that values integrity over the unattainable quest for immortality. More About Dr. Christopher Keroack: Dr. Christopher Keroack is board certified in both internal medicine and functional medicine. He received his formal education from Amherst College (BA), Springfield College (MS) and Tufts University School of Medicine (MD). In addition to his formal training, he has obtained certifications in Functional Medicine, Age Management Medicine, Naturopathic and Integrative Medicine from the Institute of Functional Medicine as well as The Cenegenics Education and Research Foundation for Age Management Medicine. He has spoken both nationally and internationally on weight loss, nutrition, fitness and functional medicine. His combination of experience and training has enabled him to develop a comprehensive and complete approach to optimizing health, wellness and vitality. Website Instagram Connect with me! Website Instagram Facebook YouTube
Carolina Reis Oliveira, PhD and co-founder of OneSkin (code: BIOHACKINGBRITTANY), exposes why so many "anti-aging" products quietly inflame your skin, accelerate cellular aging, and wreck your barrier — and what a true longevity-first skincare routine looks like instead. We unpack senescent "zombie cells", exosome facials, NAD+ creams, rating apps like EWG and Yuka, and how to choose products that are both clean and clinically effective without overloading your skin. As a mom and longevity nerd, I also ask her how women can simplify their routines without sacrificing results, especially when we're juggling babies, work, and sleep. Join my 12 Holiday Rituals Giveaway for a chance to win part of $5,500+ USD in wellness prizes. Open until December 24th! WE TALK ABOUT: 02:00 - Why OneSkin started by testing popular "anti-aging" creams on real human skin 10:35 - What senescent "zombie cells" are and why they act like rotten apples inside your skin 14:15 - Why OneSkin keeps its OS-01 peptide topical (not oral) and what that means for safety vs. supplements 17:45 - Exosome facials, plant stem cell exosomes, and how to tell if what's in the vial is actually still active 19:15 - NAD, NMN, niacinamide and so-called "mitochondria" creams — what the data really shows on skin aging 25:55 - The kinds of clinical tests and lab data Carolina looks for before she'll trust a formula 31:05 - Exactly where OneSkin fits into your routine with vitamin C, retinol, eye creams and exfoliants 34:05 - Non-comedogenic formulas, coconut oil breakouts and how OneSkin formulates for acne-prone skin 39:15 - How to actually use a gua sha for lymph drainage, jaw tension and lip lines 40:35 - The future of longevity: Shifting from "anti-aging" to extending women's healthspan and vitality into our 70s and 80s 43:40 - Hormone therapy, prevention and why "just get used to it, you're getting old" is a dangerous narrative 45:40 - How to spot longevity greenwashing in both skincare and supplements RESOURCES: Free gift: Download my hormone-balancing, fertility-boosting chocolate recipe. Explore my luxury retreats and wellness events for women. Shop my faves: Check out my Amazon storefront for wellness essentials. OneSkin's website (code: BIOHACKINGBRITTANY) and Instagram Join my 12 Holiday Rituals Giveaway before December 24th LET'S CONNECT: Instagram, TikTok, Facebook Shop my favorite health products Listen on Spotify, Apple Podcasts, YouTube Music
What if aging wasn't something that simply “happens,” but a reflection of how well your cells are able to repair, restore, and keep you in balance? Today on Rooted in Wellness, I'm joined by Dr. Nichola Conlon, scientist and founder of Nuchido, to explore how NAD, cellular repair, and lifestyle shape the way we age from the inside out. We dive into what NAD actually does in the body, why it declines so quickly, and how stress, inflammation, and modern living accelerate that loss. We also explore biological versus chronological age, what the newest tests can actually tell us, and why certain trends, NAD IVs, high-dose NMN/NR, and supplement stacking, aren't always supportive. You'll hear grounded, practical habits that naturally activate your repair pathways, along with early clinical findings showing improvements in inflammation, sleep, and even biological age. Dr. Nichola Conlon is the founder and CEO of Nuchido, where she brings years of training in molecular biology and drug development to the world of accessible longevity. Her approach is deeply science-informed yet refreshingly balanced, focused on restoring the body's own repair systems so we can feel more clear, energized, and rooted as we age. What's Discussed: (00:00) Why Nature Calms Your Cells (Not Just Your Mind) (04:42) The “Inner Repair System” Your Body Is Begging You to Remember (09:04) How Modern Life Speeds Up Aging (More Than Genetics Ever Will) (23:27) NAD 101: The Molecule Your Energy Runs On (29:19) The Truth About NAD IVs, NMN, and Supplement Stacking (37:55) How Fasting and Movement Switch Your Repair Pathways Back On (43:44) Rebuilding NAD the Way Your Body Actually Wants (48:50) What a 28-Day Clinical Trial Revealed About Biological Age (56:07) Why NAD Matters Even More in Perimenopause & Menopause (01:09:05) NAD and Sleep: The Missing Link No One Talks About Thank You to Our Sponsors: Nuchido: You can get 20% off your first order at nuchido.com with code MONA20. Learn more about Mona Sharma: Download Your FREE Guide - 12 Wellness Tips to Unlock Your Best Health Now: Ready to reclaim your vitality? Download Mona's 12 Wellness Tips and take actionable steps to transform your health, energy, and mindset. Get started now at https://monasharma.com/12tips. Visit Mona's website: https://monasharma.com – Unlock powerful tools and wisdom rooted in wellness to elevate your health, energy, and clarity. Mona blends ancient healing practices with modern science to help you achieve lasting transformation. Follow Mona on Instagram: Stay connected with Mona for daily inspiration, holistic health tips, and personal growth. Join the conversation on Instagram at https://instagram.com/monasharma. Learn more about Dr. Nichola Conlon and Nuchido: Instagram: @drnicholaconlon Instagram: @nuchido Website: https://nuchido.com/
Alzheimer's disease (AD) is linked to aging and errors in how our genes are processed, a mechanism known as dysfunctional alternative RNA splicing (ASEs). The metabolite NAD+ is known to slow AD progression in preclinical studies.This 2025 study in Science Advances provides a new mechanism . Researchers found that NAD+ augmentation corrects these harmful splicing errors. It appears to do this by regulating a key protein called EVA1C, which the study found is reduced in the hippocampus of human AD patients compared to cognitively normal ones.Using mouse models with AD-like tau pathology , supplementing with NAD+ precursors (like NR or NMN) improved memory . Critically, when the researchers blocked the EVA1C protein (via adeno-associated virus-based knockdown) in the mice's hippocampus, the memory improvements from NAD+ were lost .This suggests the NAD+-EVA1C splicing axis is a critical pathway for how NAD+ protects the brain, offering a potential new target for future AD therapies.3. Disclaimers• This information is for educational purposes only and should not be interpreted as medical advice.• The study discussed was conducted on human cells , C. elegans (worms) , and mouse models . Further research is needed to confirm these specific mechanisms in humans.• Always consult with a qualified healthcare professional before making any changes to your diet, supplement regimen, or treatment plan, especially if you have a medical condition or are taking medications.Ai R, Mao L, Jin X, et al. NAD+ reverses Alzheimer's neurological deficits via regulating differential alternative RNA splicing of EVA1C. Sci Adv. 2025;11(eady9811).#AlzheimersResearch #NAD #EVA1C #RNASplicing #NeuroscienceNAD+, Alzheimer's disease, EVA1C, alternative RNA splicing, ASEs, hTau.P301S, C. elegans, neuroprotection, neurological deficits, memory improvement, nicotinamide adenine dinucleotide, nicotinamide riboside, nicotinamide mononucleotide, tauopathy, hippocampus, spliceosome, neuronal resilience, transcriptomics, Science Advances, Ai et al 2025, HSP70, BAG1, gene regulation, NAD+-EVA1C splicing axis, neurodegeneration
Functional training is redefining what it means to stay fit for life. Instead of chasing personal records in the gym, this approach focuses on the movements that matter most—squatting, lifting, balancing, and moving with control—to preserve independence and prevent injury.In this Move for Life episode of the Live Long Podcast, Peter Bowes is joined by trainers Nate Wilkins and Shebah Carfagna, co-founders of The Ageless Workout, to explore how functional fitness supports healthy aging and long-term vitality. They discuss how to tailor workouts to your lifestyle and age, set realistic baselines, and build habits that stand the test of time.More than a trend, functional training offers a cost-effective, evidence-based path to longevity—linking movement, nutrition, sleep, and social connection to a longer, healthier life. The ultimate goal: stay capable, strong, and independent for as long as possible, compressing decline into the shortest time.You should consult a doctor or qualified fitness professional before starting any new exercise program, especially if you have existing health conditions or limited mobility.-----This podcast is supported by affiliate arrangements with a select number of companies. We have arranged discounts on certain products and receive a small commission on sales. The income helps to cover production costs and ensures that our interviews remain free for all to listen. Visit our SHOP for more details: https://healthspan-media.com/live-long-podcast/shop/ PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarEnergyBits algae snacksA microscopic form of life that could help us age better. Use code LLAMA for a 20 percent discountSiPhox Health home blood testingMeasure 17 critical blood biomarkers from home. Get a 20% discount with code LLAMA PartiQlar supplementsEnhance your wellness journey with pure single ingredients. 15% DISCOUNT - use code: MASTERAGING15Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.
If you're interested in optimising your healthspan and lifespan, this episode is not to be missed. In the quest for longevity, the spotlight has turned to NAD+ and its precursors, NMN and NR. In this episode featuring Dr. Charles Brenner, a metabolism scientist, we dive deep into the significance of these molecules and their role in healthy aging. You'll discover that NAD+ (Nicotinamide Adenine Dinucleotide) is not just a trending topic but rather a crucial player in metabolism. Learn why Charles refers to it as the "central jewel of metabolism". In the conversation, the distinction between NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside) is clarified, and you'll discover which of these molecules has the best evidence-base. You'll also find out why some popular ways to increase NAD+ are an expensive waste of time. Dr. Brenner highlights the importance of evidence-based research, citing eight randomised clinical trials demonstrating the anti-inflammatory effects of one of the NAD+ precursors in humans. One significant study focuses on peripheral artery disease (PAD), a condition affecting millions of older adults that can severely impact mobility and quality of life. Ypu'll also disciver why a simple functional test is a way better predictor of longevity than all of the espoensive epigenetic-focused Biological Age tests that are currently on the market. What You'll Learn: The Basics of NAD and Its Functions: Understand the foundational role of NAD in cellular metabolism and how it acts as a transmitter of high-energy electrons needed for energy production and cell functions. Scientific Evidence and Research: Discover the rigor behind the clinical research of NAD and its supplements, like Nicotinamide Riboside (NR), including ongoing trials and results showing anti-inflammatory properties in humans. Controversies and Misconceptions: Unpack the myths concerning longevity molecules, such as misinterpretations around resveratrol, with arguments laid out by reputable scientists like Dr. Brenner. Applications in Age-Related Diseases: Explore the potential of NR supplements in addressing conditions like peripheral artery disease and its promising though variable outcomes in treating Long COVID and neurodegenerative diseases. Critical Analysis of Clinical Trials: Learn about the importance of clinical integrity, unbiased research, and how independent laboratories contribute to credible scientific discoveries. Key Takeaways: NAD is vital for maintaining metabolic health and managing cellular stress, which is essential for healthy aging. Recent clinical trials have shown promising results for NR in reducing inflammation and improving conditions related to peripheral artery disease. There's ongoing research into NR's benefits for cognitive function, particularly its potential effects on neurodegenerative disease. Supplements should be chosen carefully, preferably ones that have been tested in clinical trials to ensure efficacy and authenticity. The conversation between Dr. Taylor and Dr. Brenner highlights the need to critically evaluate scientific claims, especially those that are widely publicised without robust evidence. Through the episode, Dr. Brenner provides deep insights into how NAD coenzymes operate within the body and why they're considered crucial for longevity research. Moreover, listeners are encouraged to discern meticulously between scientific fact and internet hype, ensuring they make informed decisions when considering supplements. The episode is a valuable resource for anyone interested in the intersection of biochemistry, aging, and healthspan science. Resources Socials: X: @CharlesMBrenner LinkedIn: https://www.linkedin.com/in/charles-brenner/ Support the Podcast If you found this conversation valuable, consider subscribing and leaving a review on your preferred podcast platform. Your feedback helps us continue to bring you insightful discussions on important health topics. 00:11 Understanding NAD+ and Longevity Molecules 01:31 Debunking Longevity Myths 03:02 The Science Behind NAD+ and Metabolism 08:46 Clinical Trials and Evidence 09:37 Peripheral Artery Disease and NAD+ 11:00 Walking Speed as a Health Indicator 13:25 Challenges with DNA Methylation Clocks 21:40 NAD+ in Metabolic Processes 23:48 The Role of NAD in DNA Repair and Cellular Health 24:09 Inflammation and Aging: The Connection 25:20 Human Longevity and Reproductive Capacity 30:02 The Hallmarks of Aging 31:11 Challenges of Living in 2025: Long COVID 31:42 Clinical Trials and NAD Supplements 34:33 The Debate on NMN vs. NR 41:58 Intravenous NAD and Its Efficacy 45:06 NAD's Role in Neurodegenerative Diseases See omnystudio.com/listener for privacy information.
Das neue Wissenschafts-Format der Biohacking-Praxis: Andreas präsentiert 3 Studien mit Biohacking-Relevanz. Diesmal zu Vitamin D, Omega 3 und Bewegung bei Senioren, zu NMN als NAD+-Booster und zur erstaunlichen Anti-Falten-Wirkung von Photobiomodulation.
Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks… Sheena: Hi Dr. C! Hope you and your team are all well. I've been a long time follower and am trying my best to incorporate all the different ways to stay healthy by following the Rain Barrel protocol. When it comes to detoxing, besides exercise and the 7-21 day detox, I dry brush, rebound and now, would like to start invest in a IF sauna. My question is, even though dry brushing and rebounding is only 5-15 mins, do I still need to do it if I get a sauna? I'm trying to save time anywhere I can. Also, regarding IF sauna, which do you prefer? The Thera360? Or Higher Dose IF Sauna Blanket? I've listened to all your podcasts that review them and they both sound great. But is there a "better" one between the two? Thanks in advance for your answer! Kirsty: Hi Stephen, I recently came across some information suggesting that resveratrol might be estrogenic. I was hoping you could clarify whether that's true. I've been taking it alongside NMN, but now I'm a bit concerned it might not be as beneficial as I initially thought. Thanks so much for all you do, I love and trust your information. Kirsty Tricia: Good morning Dr Cabral - I have a problem that I just can't see to conquer and I know if I don't I will never reach my health goals. Every night at 8pm like clockwork I want to eat. It doesn't matter what time I have dinner or what I eat for dinner. I believe it might be a habit but I can't seem to break it. I will use strong willpower for a few months start to lose weight and feel great and then my willpower gives in and I'm back to a snack at 8pm then my health start to spiral. It makes me sad that I can't win this battle. I listen to you everyday and you have helped me SO much. I just can't seem to break this vicious cycle. Do you have any advice? I go to bed early because I get up at 4:00am so I try to eat dinner at 4:30pm. Thank you! Tricia: Hi it is me again. I also do well with routine and I remember on one of your podcast you mentioned you tend to eat the same foods during the week to keep it simple. Do you mind sharing your meal plan for during the week. I need simple and routine. Also, on Monday do you still do a reset day most weeks? Thank you for taking the time to record these podcasts. Amy: I'm interested in getting the food sensitivity test for my 6 year old daughter. Is it something I can use for her (is there an age restriction)? Is it an at home urine test? Thank you Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes and Resources: StephenCabral.com/3572 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!
On this episode of Vitality Radio, Jared dives deep into one of the most fascinating frontiers in functional nutrition—brain energy. He unpacks how ATP fuels your mind, why BDNF acts like “fertilizer for neurons,” and how lifestyle stressors, toxins, and poor sleep can dim your mental lightbulb. From there, he explores the natural tools that can reignite focus, memory, and long-term cognitive vitality. You'll hear how powerhouse nutrients can support mitochondrial performance, boost brain-derived neurotrophic factor, and promote sharper thinking—without the crash of caffeine or pharmaceuticals. Jared wraps up with three practical, results-driven protocols: one for focus and ADHD support, one for immediate memory and cognition, and one for long-term prevention of cognitive decline. Each stack can be customized to fit your individual goals so you can think clearer, focus longer, and age smarter—naturally.Brain Boosting Protocol CollectionShop the collection! Bundle and save - no code needed, just add to your cart to get:Buy 2 at 10% offBuy 3-4 at 15% offBuy 5+ at 25% offAdditional Information:Brain Boosting Protocol Blog Post#335: The Latest Research on Preventing and Reversing Dementia and Alzheimer's with Dr. Dale Bredesen#570: Liquid Yoga & Mind Fuel: Harnessing Mushrooms and Herbs for Focus and Calm#511: Unraveling NAD+ and NMN for Longevity and Anti-AgingVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.
The plank may look simple, but it's one of the most effective full-body exercises for building strength, stability, and balance. In this Move for Life episode, Peter Bowes is joined by trainers Nate Wilkins and Shebah Carfagna, co-founders of The Ageless Workout, to explore how mastering the plank can transform your movement and longevity.They break down the fundamentals of proper form, explain safe progressions from wall and knee-supported planks to more advanced variations, and discuss how to integrate planks into your workouts for the greatest benefit.The conversation emphasizes control over duration, the importance of protecting the lower back, and why medical clearance and qualified guidance are key—especially for beginners and older adults. Whether you're building a stronger core or seeking better posture and balance, this episode offers practical insights to make every plank count. -----This podcast is supported by affiliate arrangements with a select number of companies. We have arranged discounts on certain products and receive a small commission on sales. The income helps to cover production costs and ensures that our interviews remain free for all to listen. Visit our SHOP for more details: https://healthspan-media.com/live-long-podcast/shop/ PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarEnergyBits algae snacksA microscopic form of life that could help us age better. Use code LLAMA for a 20 percent discountSiPhox Health home blood testingMeasure 17 critical blood biomarkers from home. Get a 20% discount with code LLAMA PartiQlar supplementsEnhance your wellness journey with pure single ingredients. 15% DISCOUNT - use code: MASTERAGING15Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.
This episode originally aired as #511 on 2/22/25 and we are bringing it to you again! NAD+, NMN, NR, Longevity…these buzz words have been making the rounds, but what do they mean and why are they important? On this episode of Vitality Radio, Jared breaks it down as he discusses how all of these factor into anti-aging. You'll learn how NAD+ is essential for energy production, DNA repair, and more - and how you can boost your body's production of it by supplementing with NMN. The conversation delves into the roles of sirtuins in cellular health, metabolism, inflammation, cognition, and overall aging. Products:Vitality Nutrition Vital NMNAdditional Information:#497: The Vital Role of Glutathione and How to Deliver it to Your Cells with Dr. Nayan PatelVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.
A strong core is far more than a set of visible abs - it's the foundation for every movement you make. This intricate network of muscles stabilizes your spine, improves posture, and protects against injury. As we age, maintaining core strength and endurance becomes essential for balance, mobility, and overall vitality.In this Move for Life conversation, Peter Bowes talks with Nate Wilkins and Shebah Carfagna, fitness professionals and co-founders of the Ageless Workout, about how to build and sustain core strength for life. They discuss simple, equipment-free exercises - like bird dogs, hip bridges, and planks - that create a strong, functional foundation when performed with proper form and mindful engagement.By training both strength and endurance through timed holds, structured sets, and purposeful movement, you can support longevity, confidence, and pain-free mobility at any age.-----This podcast is supported by affiliate arrangements with a select number of companies. We have arranged discounts on certain products and receive a small commission on sales. The income helps to cover production costs and ensures that our interviews remain free for all to listen. Visit our SHOP for more details: https://healthspan-media.com/live-long-podcast/shop/ PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarEnergyBits algae snacksA microscopic form of life that could help us age better. Use code LLAMA for a 20 percent discountSiPhox Health home blood testingMeasure 17 critical blood biomarkers from home. Get a 20% discount with code LLAMA PartiQlar supplementsEnhance your wellness journey with pure single ingredients. 15% DISCOUNT - use code: MASTERAGING15Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.
Was bringt NAD+ wirklich? Unterschiede zu NADH, Sinn und Unsinn von Infusionen, Supplements, Messung, Gender-Gaps & Lifestyle-Hebel.
You think your posture is just muscles and bones. But what if the “scaffolding” that holds you together is also storing your emotions, shaping your face, and quietly dictating how you move through the world?This week on Live Well Be Well, Jason Van Blerk - biomedical physiologist, kinesiologist, and co-founder of Human Garage - joins me to explore fascia: the body's intelligent, water-rich network that connects everything. We unpack how rotation, breath, and vibration can unwind tension, release emotion, and restore flow - often in minutes.Jason shares his journey from injured athlete to fascia educator, the simple daily maneuvers he teaches, and the surprising science that links stiffness, mood, and the nervous system. We also talk barefoot living, grounding, and why “be the change” is more than a quote - it's biology.Here's what we dive into:How fascia functions as an intelligent, water-based organ that sends and receives information.Why emotions like fear and desire shape movement, posture, and even facial structure.How counter-rotation and breath unwind restrictions more effectively than linear stretching.What a living fascia looks like under magnification, and why dead-tissue dissections miss the point.Why stiffness in the neck/upper back correlates with low mood, and what one session can shift.How daily micro-manoeuvres (15 minutes) restore flow, reduce stress, and change how you see the world.What vibration and sound do at a cellular level, and how your words “program” your body.How barefoot walking and grounding re-charge cellular voltage and improve whole-body mechanics.Why self-care comes first: the limits of quick fixes, and the power of simple, repeatable practices.How to start today with one shoulder release and a gentle rotation sequence you can do anywhere.Love,Sarah Ann
Kwame Terra is on a mission to make movement a cultural norm and health an accessible part of everyday life. Through his community-based bEHR Health platform, the New Orleans athlete is reimagining wellness through walking, technology, and social connection. His mission: to make healthy choices desirable, accessible, and part of daily life, particularly within Black communities that have long faced systemic health gaps.Terra promotes walking as a low-cost, high-impact path to improved longevity and reduced health disparities. He's developed tools such as personal health scores and participation challenges that turn physical activity into an engaging, collective experience. Earlier this year, he walked more than two million steps in 30 days - a record-breaking endurance feat that underscored his message that modest, consistent movement can transform health outcomes. Now, with the launch of the bEHR Health app, he aims to deliver real-time health feedback and community-driven challenges directly to users' hands - turning wellness into a shared, sustainable habit.In this conversation with Peter Bowes, Terra discusses the role of culture, environment, and feedback in shaping lasting habits - and why small steps, taken together, can help close health gaps and extend healthspan.Related: Check out our 20-part series, Move for Life-----This podcast is supported by affiliate arrangements with a select number of companies. We have arranged discounts on certain products and receive a small commission on sales. The income helps to cover production costs and ensures that our interviews remain free for all to listen. Visit our SHOP for more details: https://healthspan-media.com/live-long-podcast/shop/ PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarFit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts SpotifyEnergyBits algae snacksA microscopic form of life that could help us age better. Use code LLAMA for a 20 percent discountSiPhox Health home blood testingMeasure 17 critical blood biomarkers from home. Get a 20% discount with code LLAMA PartiQlar supplementsEnhance your wellness journey with pure single ingredients. 15% DISCOUNT - use code: MASTERAGING15Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.
A simple one-leg stand is a surprisingly powerful test of balance, coordination, and how well your body is aging. In this episode of our series, Move for Life, trainers Nate Wilkins and Shebah Carfagna show how this fun, focused move lights up your core, glutes, and posture—while improving breath control and body awareness. They guide you through progressions—from fingertip support to eyes closed and longer holds—that boost stability, confidence, and even gait. Yoga, barre, and Pilates make great complements. Nate and Shebah also stress practicing on both sides, focusing on form (not ego!), and enjoying the process. With a playful attitude and a “start where you are” mindset, this simple balance drill can help keep you strong, steady, and independent for years to come.You should consult your healthcare providers before starting or modifying a fitness routine.-----This podcast is supported by affiliate arrangements with a select number of companies. We have arranged discounts on certain products and receive a small commission on sales. The income helps to cover production costs and ensures that our interviews remain free for all to listen. Visit our SHOP for more details: https://healthspan-media.com/live-long-podcast/shop/ PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarEnergyBits algae snacksA microscopic form of life that could help us age better. Use code LLAMA for a 20 percent discountSiPhox Health home blood testingMeasure 17 critical blood biomarkers from home. Get a 20% discount with code LLAMA PartiQlar supplementsEnhance your wellness journey with pure single ingredients. 15% DISCOUNT - use code: MASTERAGING15Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.
In this Huberman Lab Essentials episode, my guest is Dr. David Sinclair, PhD, a professor of genetics at Harvard Medical School and a leading expert on the biology of aging. We discuss the cellular and molecular mechanisms of aging—and how specific behaviors, such as fasting, regular exercise and NAD⁺-boosting compounds like NMN, can activate the body's natural longevity pathways. This discussion highlights how lifestyle choices profoundly influence the aging process and may even slow or reverse key aspects of biological aging. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AGZ by AG1: https://drinkagz.com/huberman David: https://davidprotein.com/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps (0:00) David Sinclair (0:20) Longevity, Anti-Aging, Aging as a Disease (2:27) Causes of Aging; Epigenome & Genes (4:53) CD & Scratches Analogy, DNA, Silencing & Expressing Genes (6:44) Physical Appearance & Aging (7:36) Sponsor: David (8:54) Childhood Development & Aging, Horvath Clock, Accelerate Aging (11:30) Rates of Puberty & Aging, Growth Hormone (12:37) Body Size & Longevity; Epigenetics (13:07) Fasting, Calorie Restriction & Longevity, Sirtuins, Insulin & Glucose (16:31) Tool: Skip a Meal (17:07) Longer Fasts & Autophagy, “Deep Cleanse” (18:07) Sponsor: AGZ by AG1 (19:36) Fasting, Fluids, Electrolytes (20:16) Sirtuins, Glucose, mTOR & Fasting; Leucine, Tool: Pulsing Behaviors (24:24) Breaking a Fast, Tools: Do Your Best; Transitions (27:00) Sirtuins, NAD, NMN Supplementation (29:04) Sponsor: Eight Sleep (31:10) Iron & Senescent Cells; Personalize Medicine (32:40) Tool: Blood Markers, CRP (34:50) Tool: Aerobic & Resistance Exercise (35:55) Estrogen, Fasting & Fertility; Aging & Rejuvenation (38:20) Acknowledgements Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices
In this solosode of The Energy Code, Dr. Mike unveils the most comprehensive update yet to BioLight's flagship supplement — BioBlue — and takes listeners deep inside the quantum bioenergetic thinking that shaped its redesign. What began as a methylene-blue-based mitochondrial catalyst has evolved into a next-generation longevity systemintegrating deuterium-depleted water, elevated NMN, taurine, and trace gold-silver resonance compounds. Dr. Mike breaks down the science and reasoning behind each refinement: why Litewater's 10 ppm deuterium-depleted water now forms the clean matrix for all BioBlue liquids, how NMN has been increased ten-fold (10 mg → 100 mg) to meaningfully expand NAD⁺ pools and drive biogenesis, and how taurine stabilizes mitochondrial membranes and calcium signaling for endurance and resilience. He explains the subtle yet powerful tweaks — like a 50 % increase in colloidal gold and silver and a 40 % reduction in fulvic acid — that sharpen redox coherence and enhance longevity signaling. Dr. Mike dives into: Overview of how BioBlue progressed from a simple methylene-blue solution to a full mitochondrial optimization system. Why all BioBlue liquids now utilizes Litewater for cleaner proton flow and improved ATP efficiency. Why NMN increased from 10 mg → 100 mg per dose to meaningfully raise NAD⁺ levels, drive biogenesis, and enhance DNA repair. Why the addition of Taurine – 100 mg per serving for membrane stability, calcium regulation, and long-term mitochondrial resilience. Enhanced Trace Elements – 50 % more colloidal gold & silver plus refined fulvic acid for smoother redox flow and higher photodynamic efficiency. This episode isn't just about formulation — it's about why every molecule matters in the pursuit of mitochondrial efficiency, redox stability, and long-term cellular youthfulness. Mike also previews BioLight's upcoming new website, pre-Black-Friday event, and a soon-to-launch BioBlue Lite product line for those seeking simplicity without compromise. Key Topics Covered Evolution of BioBlue — from the original methylene blue + NMN formula to a comprehensive mitochondrial optimization system. Integration of Deuterium-Depleted Water (Litewater, 10 ppm) — explanation of how lowering deuterium enhances ATP production, redox efficiency, and longevity potential. NMN Upgrade (10× Increase) — new 100 mg per serving dosage for boosting NAD⁺ levels, mitochondrial biogenesis, DNA repair, and energy metabolism. Addition of Taurine (100 mg per serving) — supports membrane integrity, calcium balance, ROS buffering, and cellular longevity signaling. Enhanced Colloidal Gold & Silver (50 % Increase) — improved redox stability, electron flow, and photodynamic synergy with methylene blue and red light. Refined Wu Jin Sun Fulvic Acid (−40 %) — optimizes redox balance and mineral transport while improving synergy between all active compounds. Comprehensive Mitochondrial Benefits — improved ATP efficiency, autophagy, and mitochondrial biogenesis for cleaner, more resilient energy production. New Product Lineup — introduction of BioBlue Lite and BioBlue Leuco Lite (simplified methylene blue + water versions) for accessible mitochondrial support. Key Quotes from Dr. Mike “Deuterium-depleted water doesn't just make the mitochondria go faster—it helps them run truer, cleaner, and more efficiently.” “We've moved BioBlue from a trace metabolic nudge to a real mitochondrial optimization protocol that supports redox cycling, biogenesis, and longevity pathways in a quantifiable way.” “Taurine turns BioBlue from a fast-acting energy compound into a cellular longevity stack—supporting repair, recycling, and resilience.” “By increasing colloidal gold and silver within their optimal bio-signal zones, BioBlue transforms from a chemical redox supplement into a biophysical energy transducer.” “Each change — from Litewater to taurine — was made to help your mitochondria run longer, cleaner, and more accurately. This is longevity through bioenergetics.” Episode Timeline 00:00 – Announcements: Pre-Black Friday + new website 04:00 – The origin of BioBlue and its evolution 10:00 – Introducing the upgraded BioBlue formula 11:00 – Why BioLight partnered with Light Water 12:00 – How deuterium slows mitochondrial ATP production 17:00 – Functional benefits of deuterium-depleted water 19:00 – 10x increase in NMN for energy and repair 27:00 – Synergy between NMN and methylene blue 30:00 – Adding taurine for stability and longevity 39:00 – Increasing colloidal gold for photonic synergy 46:00 – Boosting colloidal silver for redox protection 52:00 – Why lowering fulvic acid improves coherence 56:00 – What's next: BioBlue Light + legacy pricing offer 01:02:00 – Dr. Mike's closing thoughts on mitochondrial optimization Resources & References Deuterium Depletion and Mitochondrial Efficiency Boros, L. G. Deuterium Depletion and Cellular Bioenergetics. Frontiers in Oncology (2020). Sagalevsky, V. — Light Water: The Science of Deuterium-Depleted Hydration (interview referenced in episode). Nicotinamide Mononucleotide (NMN) & NAD⁺ Metabolism Mills, K. F. et al. Long-term administration of NMN mitigates age-associated physiological decline in mice. Cell Metabolism (2016). Yoshino, J. et al. NAD⁺ intermediates: The biology and therapeutic potential of NMN and NR. Cell Metabolism (2018). Taurine and Longevity Pathways Wang, W. et al. Taurine deficiency as a driver of aging. Science (2023). Schaffer, S. W. et al. Physiological roles of taurine in the heart and mitochondria. Journal of Biomedical Science (2010). Colloidal Gold & Silver in Cellular Redox Systems Li, Y. et al. Gold nanoclusters enhance mitochondrial cytochrome c oxidase activity. ACS Nano (2019). Kim, Y. S. et al. Silver nanoparticles exhibit SOD- and catalase-like activity for redox modulation. Nano Research (2020). Fulvic & Humic Acids as Bioactive Redox Modulators Senesi, N. Nature of humic substances and their interactions with trace metals and organics in the environment. Soil Science (1992). Wu Jin San extract — traditional Chinese “gold medicine” formulation known for enhanced mineral transport and detoxification support. Additional Mentions PGC-1α, SIRT1/SIRT3, and Autophagy pathways in mitochondrial biogenesis and longevity. Quantum redox coupling and plasmonic resonance as mechanisms for light-driven bioenergetic optimization.
Today, I'm thrilled to welcome Dr. Amy Killen, a visionary in hormone optimization and regenerative medicine who is transforming the conversation around women's health and longevity. In this episode, Dr. Killen shares her personal journey—from witnessing her mother's struggle after a hip fracture, to becoming a steadfast advocate for correcting the myths and misinformation that still surround estrogen, progesterone, and testosterone optimization. Episode Timestamps: Ferritin, iron, and hormonal health basics ... 00:00:43 Dr. Amy Killen's evolving hormone focus ... 00:04:02 Women's Health Initiative and estrogen myths ... 00:06:31 Importance of hormone optimization vs. stem cells ... 00:10:25 Testosterone for women: symptoms, labs, delivery options ... 00:12:05 Side effects and nuances of testosterone therapy ... 00:14:01 SHBG, free testosterone, and lab variability ... 00:16:38 Libido, PT-141, and the biopsychosocial lens ... 00:21:46 Iron and ferritin: sweet spot and skin implications ... 00:29:16 Hot vs. HRT: definitions and individualization ... 00:34:23 Debunking estrogen and breast cancer myths ... 00:41:30 Aging expectations and finding the right doctor ... 00:43:18 Advice for women by decade—20s, 30s, 40s, etc. ... 00:47:20 Our Amazing Sponsors: Tro Zzz by Troscriptions - This isn't just melatonin—it's a powerhouse! Oblipair gives you honokiol and agarin to enhance GABA binding, while adenosine and cordycepin boost sleep drive and deep sleep. CBD, CBN, and 5‑HTP round it out. Head to troscriptions.com, use NAT10, and get 10% off your first order. NMN+G Rx by Wizard Sciences - A scientifically formulated blend of NMN, ginsenosides from Panax ginseng, and apigenin. Together, they enhance mitochondrial function, boost NAD+ levels, and support cellular repair. Go to wizardsciences.com and look for NMN+G. Use code NAT15 at checkout to get 15% off your purchase. Probiotic Breakthrough by Bioptimizers: uses a stress-tested Lactobacillus plantarum strain that showed over 30× greater survival in bile and intestinal fluid vs. generic strains. Save 15% at bioptimizers.com/bionat and use code BIONAT for 15% off any order. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group
Dan talks about the ongoing Democrat shutdown + NMN takes a look at Trump's visit with the new Japanese Prime Minister | aired on Tuesday on October 28th, 2025 on Nashville's Morning News with Dan MandisSee omnystudio.com/listener for privacy information.
I denne episoden snakker vi med Jan Roger Johansen – personlig trener, biohacker og helseentusiast med en dyp fascinasjon for kroppens biologi og potensiale.Fra tidlig interesse for trening og kosthold, til egne erfaringer med C5-prolaps og reisen gjennom selvhealing, bevegelse og biohacking, deler Jan Roger hvordan både han og kona fant løsninger utenfor tradisjonell medisin.Vi går i dybden på hva som faktisk fungerer, og hvor grensen går mellom optimalisering og overdrevet hacking.Tema vi snakker om:Lys og varme: RLT, IR-sauna + niacin detox, UVA/UVB-balansenKulde: isbading, kalddusj og nedkjøling for prestasjonTilskudd og plantebaserte hacks: NMN, Resveratrol, Berberine, kreatin m.fl.Nervestimulering og indre arbeid: vagusnerven, pust, meditasjon og jordingErnæring og faste: fermentert mat, vannfaste, salter og timingStyrketrening som biohack: muskler som “reserveorgan” og nøkkelen til lang levetidTesting og målinger: blodprøver, wearables og Muhdo-testen – biologisk alder 45 → 39,9 årJan Roger deler også sitt store mål:Å løfte 300 kg markløft som 50-åring – og bevise at alder bare er et tall.Mer info om Jan Roger her: www.utxas.no (hjemmeside)Facebook/Instagram: petestrengthYouTube: @PeteStrength-UTXAppStore:PeteFor selve biohacking styrkereise -> 300kg i markløft: janrogerjohansen76Takk til vår samarbeidspartner:Oslo skinlab: Osloskinlab.no: rabattkode: bio60 @osloskinlabBoken vår BIOHACKING, - 21 uker på BESTSELGERLISTEN den finner du her:https://www.ark.no/produkt/boker/hobbyboker-og-fritid/biohacking-9788205611474Nysgjerrig på neste Biohacking Weekend 21 og 22 mars 2026? Mail: christin@kongresspartner.no
How we spend our mornings sets the tone for everything that follows — not just for how we feel today, but for our long-term health, both mind and body. In this episode, I walk through my current morning routine — from what I drink first thing to the supplements I use and why. Not as a prescription, but as a conversation starter to help you build your own version — one that fits your lifestyle and supports your energy, focus and wellbeing. LINKS Molly's podcast on Creatine | https://bit.ly/431X2RW Molly's column on Collagen | https://bit.ly/42v2JaT More on NMN | https://bit.ly/4nGCQ05 WGNO recipe for a similar ‘Clarity Cocktail' | https://bit.ly/4mVSJyw Learn more about your ad choices. Visit megaphone.fm/adchoices
Dr. Hoffman continues his conversation with Dr. Rob Verkerk, Founder, Executive & Scientific Director, Alliance for Natural Health International & Alliance for Natural Health USA.
Dr. Robert Verkerk, the Executive Director of the Alliance for Natural Health (ANH), discusses a wide range of topics, including the intersection of high-tech medical advances and natural therapies. Dr. Verkerk explains the mission of ANH, emphasizing the defense of health freedom and the promotion of natural approaches to health. They delve into various initiatives that ANH is working on, such as defending access to natural thyroid, reversing bans on important supplements like NMN and NAC, and challenging FDA regulations that restrict information on the benefits of natural products. The episode also highlights the importance of maintaining a balanced approach to healthcare and the ongoing efforts to reform regulatory frameworks that favor pharmaceutical interventions over natural alternatives.
In this episode, we unpack the vital role of NAD in cellular energy, metabolism, immune function, and sleep. Learn how precursors like NMN and NR support NAD production and why delivery method matters. We explore how genetics influence your response to food, exercise, and toxins—and how personalized testing can unlock better recovery, performance, and longevity. From DNA to mitochondria, this conversation blends science with actionable insights for living younger, longer.Get a FREE copy of Health, Hope & Freedom: https://sherwood.tv/For Kingdom Products visit: https://shop.fmidr.com/Interested in becoming a patient? https://fmidr.com/plans/Our privacy policy & disclaimer apply to this video. You can view the details here:https://fmidr.com/privacy-policy#NADBoost, #LongevityScience, #MitochondrialHealth, #DNARepair, #HealthyAging, #GeneticTesting, #CellularEnergy, #SleepRecovery, #MetabolicHealth, #BiohackingLife, #SirtuinActivation, #PerformanceGenetics
NAD+ Anti-Aging Breakthrough: How This Molecule Could Reverse Aging and Treat Alzheimer's Disease | Clinical Trial Results from Leading Longevity Researcher Dr. Evandro FangSome links are affiliate links so we will earn a commission when they are used to purchase products.Dr. Evandro Fang from the University of Oslo reveals groundbreaking research on NAD+ and its role in combating aging and neurodegenerative diseases. In this interview, Dr. Fang discusses his lab's pioneering work on mitophagy (mitochondrial cleanup) and how NAD+ precursors like NR and NMN have shown remarkable results in clinical trials for premature aging disorders. He shares dramatic case studies, including a 3-year-old Austrian boy who regained motor skills after NAD+ treatment, and explains the molecular mechanisms behind aging at the cellular level. The conversation covers his upcoming Phase 2 clinical trial using Urolithin A for Alzheimer's disease, the challenges of translating longevity research into approved therapies, and combination approaches involving exercise and caloric restriction. Dr. Fang provides practical insights into current NAD+ supplementation evidence while addressing safety concerns and optimal dosing strategies. This technical but accessible discussion offers valuable perspectives on the future of anti-aging medicine and therapeutic interventions for age-related diseases.
This week, Liz covers your questions on skin and weight loss, gel nails safety, pro-ageing supplements, and overheating.There's Linda's Q on how she can keep her skin feeling plump and bouncy post-weight loss, and Liz looks at whether shellac and gel manicures are really safe for Kate.Liz takes a deep dive into pro-ageing supplements NMN and glutathione for Susie, and helps Dottie to cool down with overheating.Links mentioned in the episodeIngenious Collagen+ - save 15% with LIZLOVESAncient + Brave True Collagen - save 20% with LIZLOVESIs NMN safe to take?A Better Second Half by Liz EarleHave a question for Liz? Send a WhatsApp message or voicenote to 07518 471846, or email us at podcast@lizearlewellbeing.com for the chance to be featured on the showPlease note, on some occasions, we earn revenue if you click the links and buy the products, but we never allow this to bias our coverage and always honestly review. For more information please read our Affiliate Policy. Hosted on Acast. See acast.com/privacy for more information.
Watch the FULL podcast here: https://youtu.be/AySFUeR1pw8Are NAD+ drips or NMN supplements a smart way to support longevity? I connect what NAD+ actually is with what current human studies show and why dosage, delivery and safety still have big question marks.This clip takes a closer look at what NAD+ (nicotinamide adenine dinucleotide) does in cellular energy, why interest has grown around aging, and how much of the hype is based on animal data rather than robust human trials. I'm exploring with my guest the difference between oral supplements and IV drips, including why IV bypasses digestion but still may not deliver NAD+ where it's needed inside cells, and the fact that effective dosing schedules are unknown. We discuss reported side effects from IV drips like flushing and rapid heart rate, the theoretical concern that excessive NAD+ could support cancer cell proliferation in certain contexts, and how high-dose single nutrients can disrupt balance when nutrients normally work in synergy. As a nutritionist and health communicator, I weigh the evidence against the costs and risks, and point to practical options with stronger support for mitochondrial health: exercise such as HIIT and zone 2 training, possibly cold exposure, investing in mental health, and dietary precursors from foods like green vegetables, fish, mushrooms and edamame.Dr Rupy Aujla in conversation with Sarah Ann Listen to the full episode here.Watch the full episode on YouTube here.***This episode is sponsored by: NOWATCH: Health tracking reimaginedKnow your body, trust yourself.15% off with code LWBW15 at nowatch.com***Sign up to Sarah's Compassionate Cure newsletter: Science Simplified, Health Humanised. Join thousands in exploring actionable insights that prioritise compassion, clarity, and real-life impact. https://sarahmacklin.substack.com/***Let's be friends!
Iron Radio Episode: Peak Week Strategies and the Science of Glycogen LoadingIn this episode of Iron Radio, hosts Coach Phil Stevens, Dr. Mike Nelson, and Dr. Lonnie Lowery discuss a range of topics including updates on NAD Boosters and NMN, the complexities of glycogen depletion and reloading for bodybuilding contests, and practical tips for peak week preparations. The hosts share their experiences, scientific insights, and recommendations for managing diet and supplements during the critical pre-contest period. They also touch on the importance of staying hydrated and the value of walking for maintaining fitness. Tune in for expert advice on becoming more resilient, recovering faster, and optimizing performance.00:44 Upcoming Events and Announcements02:09 Listener Feedback and NAD Boosters Discussion02:52 FDA Regulations and Supplement Industry Insights05:23 NAC and Its Benefits12:43 Iron Radio Updates and New Projects15:42 Listener Mail: Glycogen Depletion and Reloading18:55 Creatine and Carb Loading Strategies19:19 Performance Enhancing Drugs and Water Retention20:09 Best Practices for Endurance and Physique Athletes21:56 Carb Loading for Female Athletes23:03 Avoiding Peak Week Mistakes26:36 Fluid Swings and Weight Management29:30 The Benefits of Walking for Weight Loss Donate to the show via PayPal HERE.You can also join Dr Mike's Insider Newsletter for more info on how to add muscle, improve your performance and body comp - all without destroying your health, go to www.ironradiodrmike.com Thank you!Phil, Jerrell, Mike T, and Lonnie
Today, I'm joined by the remarkable Dr. Lisa Koche, a leukemia survivor turned clinician who has spent her career bridging the worlds of conventional, functional, and quantum medicine. In our conversation, Dr. Koche opens up about her unique journey—from facing a life-altering cancer diagnosis at just fifteen, to questioning conventional medical dogma, to becoming a pioneer in mitochondrial health, personalized medicine, and nervous system regulation. Episode Timestamps: Leukemia diagnosis and integrative healing journey ... 00:04:00 From patient to physician: asking “why” in medicine ... 00:07:00 Building collaborative, personalized care ... 00:11:00 Biohacking, mitochondria, and the limits of one-size-fits-all ...00:13:00 Wearables, nervous system, and self-assessment ... 00:18:00 Quantum biology, intuition, and energetic health ... 00:23:00 Supplements, subtle energy modalities, and future trends ... 00:32:00 Regenerative and mitochondrial testing advances ... 00:34:00 Nervous system regulation and the risk of overdoing biohacks ... 00:41:00 Guiding patients: self-awareness, nature, and media boundaries ... 00:44:00 Food, minerals, intention, and foundational self-care ... 00:55:00 Bridging science, energy, and personal sovereignty ... 01:00:00 A paradigm-shifting energy healing experience ... 01:02:00 Our Amazing Sponsors: Digestive Bitters by Just Thrive - One capsule before eating helps your body absorb more nutrients, ease digestion, and leave you feeling light instead of weighed down. Head over to Justthrivehealth.com/discount/NAT and use code NAT20 for 20% off. NootroPept by LVLUP - an advanced cognitive enhancement formula that combines fast-acting neuropeptides, cholinergic support, and mitochondrial-boosting compounds to sharpen mental clarity, memory, and long-term brain performance. Visit https://lvluphealth.com/ and use code NAT at checkout for 20% off. NMN+G Rx by Wizard Sciences - A scientifically formulated blend of NMN, ginsenosides from Panax ginseng, and apigenin. Together, they enhance mitochondrial function, boost NAD+ levels, and support cellular repair. Go to wizardsciences.com and look for NMN+G. Use code NAT15 at checkout to get 15% off your purchase. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group
Upgrade your week in just 10 minutes with D(AI)ve Asprey's essential rundown on what matters most in longevity, biohacking, AI health tech, and medical freedom. This episode covers: • Apple Cider Vinegar Myth Busted A weight-loss study just got retracted. ACV will not melt fat, but it may blunt glucose spikes or ease digestion when diluted in water before carb-heavy meals. Skip the shots and protect your teeth. Source: https://www.sciencedaily.com/releases/2025/10/251001092216.htm • NMN Is Back The FDA reversal puts NMN back on shelves as a clean NAD precursor. Dave explains why quality, cycling, and stacking with anti-inflammatory strategies make the difference. Source: https://www.prnewswire.com/news-releases/renue-by-science-celebrates-fda-reversal-confirming-nmn-is-lawful-for-use-in-dietary-supplements-302573317.html • Poor Sleep Ages Your Brain Machine learning MRI studies show poor sleep makes your brain biologically older and raises dementia risk. Dave shares the three dials to track (deep sleep, REM, resting heart rate) and the three biggest levers to fix them. Source: https://www.sciencedaily.com/releases/2024/10/241023171543.htm • Psilocybin for Lasting Reset New research finds a single guided dose can unlock plasticity, ease pain patterns, and lift mood for weeks. Dave outlines safe protocols, integration steps, and why it is a strategic reset tool, not a party trick. Source: https://www.sciencedaily.com/releases/2025/06/250616040215.htm • AI Detects Cancer Earlier A new AI tool called DOLPHIN can find hidden genetic markers to flag cancer risk sooner. Pairing high tech scans with low tech terrain fixes like sleep, muscle, and insulin control is the prevention model that works. Source: https://www.sciencedaily.com/releases/2025/10/251001092206.htm All source links provided for easy reference to the original reporting and research above. This is essential listening for fans of biohacking, hacking human performance, functional medicine, and longevity who want actionable tools from Host Dave Asprey and a guest who embodies what it means to age with energy, clarity, and vitality. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Apple cider vinegar, weight loss myths, NMN supplements, NAD precursors, cellular energy, sleep and dementia, brain aging, deep sleep optimization, REM sleep, psilocybin therapy, BDNF, neuroplasticity, pain relief, mood reset, AI cancer detection, early cancer screening, biohacking news, longevity science, Dave Asprey, Human Upgrade podcast Thank you to our sponsors! Screenfit | Get your at-home eye training program for 40% off using code DAVE https://www.screenfit.com/dave. LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser. Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave. Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Introduction 0:18 — Story 1: Apple Cider Vinegar and Weight Loss 1:49 — Story 2: NMN is Back in Supplements 3:31 — Story 3: Sleep and Brain Health 5:39 — Story 4: Psilocybin and Lasting Relief 7:49 — Story 5: AI Tool DOLPHIN for Early Cancer Signals 9:48 — Conclusion & Weekly Roundup See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Extending our healthy years isn't just about eating well and exercising — it's also about the systems around us. Social policies, public health programs, and access to care all play a huge role in how long and how well we live. In this episode, we look at what it takes to improve health for everyone, everywhere. We each have personal choices to make, but what about the bigger picture?Dr. Tyler Evans is a physician, infectious disease specialist, and author of Pandemics, Poverty and Politics: Decoding the Social and Political Drivers of Pandemics from Plague to Covid-19.In a wide-ranging conversation with Peter Bowes, Dr. Evans connects stalled life expectancy to weakened safety nets, unequal access to healthcare, and the cracks exposed by recent global crises. He emphasizes practical action — meeting people where they are, funding prevention, and rebuilding systems that can spot and stop health threats early. Drawing on his experience from Los Angeles's Skid Row to global epidemic response, Evans calls for a non-partisan, evidence-driven approach that focuses on those most at risk — because when the most vulnerable communities thrive, everyone benefits.----This podcast is supported by affiliate arrangements with a select number of companies. We have arranged discounts on certain products and receive a small commission on sales. The income helps to cover production costs and ensures that our interviews remain free for all to listen. Visit our SHOP for more details: https://healthspan-media.com/live-long-podcast/shop/ PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarEnergyBits algae snacksA microscopic form of life that could help us age better. Use code LLAMA for a 20 percent discountSiPhox Health home blood testingMeasure 17 critical blood biomarkers from home. Get a 20% discount with code LLAMA Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.
In this episode, Dr. Jones talks again with Dr. Paul Anderson, naturopathic doctor, researcher, and teacher. He joined the podcast last year to talk about cholesterol and lipid labs. This time the focus is on NAD (Nicotinamide Adenine Dinucleotide) and why it matters for your health.They explain what NAD does in the body, especially for energy, brain function, and recovery. You'll hear how NAD levels drop as we age, how alcohol and medications can drain it faster, and the different ways the body makes NAD on its own.Dr. Anderson also talks about today's options, from supplements like NMN, NR, and niacinamide to IV therapy. He shares when IVs make sense, when oral forms might be enough, and what to know about side effects and safety, including the common question about NAD and cancer.This is a straight talk about NAD, what's real and what's hype, and how it can support energy, recovery, and long-term wellness.
Momentum Shake with Michael Tecku – The Longevity Nutrition Formula Looking for a complete longevity shake that delivers clinically dosed ingredients for energy, focus, muscle recovery, and gut health—all in one? In this episode, Debbie talks with Michael Tecku, creator of Momentum Shake, to uncover the science and sourcing behind this all-in-one formula. Learn how it combines 30 g grass-fed Irish whey protein, collagen, colostrum, NMN for NAD⁺, lion's mane, methylated B vitamins, electrolytes, L-glutamine, and hyaluronic acid at research-backed doses for true cellular support.
In this episode of Accelerated Health with Sara Banta, I talk about one of the hottest topics in the biohacking and longevity world: NAD Supplements — Miracle Molecule or Metabolic Trap?If you've tuned into a biohacking podcast, stepped into an IV clinic, or scrolled through a longevity forum, you've likely heard the hype around NAD+. It's being called the cellular currency of youth—linked to mitochondrial power, anti-aging benefits, brain health, and even lifespan extension.But here's the truth no one's talking about: NAD+ isn't always safe. I talk about how NAD+ could be harmful if your metabolic terrain is compromised by histamine intolerance, methylation issues, sulfur sensitivity, spike protein exposure, or even hidden cancer.Before you book your next NAD+ infusion or stock up on NMN supplements, watch this episode first.Supplements Featured In This Episode:• Acceleradine® Iodine https://www.acceleratedhealthproducts.com/products/acceleradine-iodine-supplement • Accelerated Liver Care™ https://www.acceleratedhealthproducts.com/products/accelerated-liver-care • Accelerated C60™: https://www.acceleratedhealthproducts.com/products/accelerated-c60 • Accelerated Methylene Blue® https://www.acceleratedhealthproducts.com/products/accelerated-methylene-blue-supplement • Accelerated AMINOS™ https://www.acceleratedhealthproducts.com/products/accelerated-aminos • Accelerated Cogniblast® https://www.acceleratedhealthproducts.com/products/cogniblast-nootropic Not sure what food to eat and avoid? This guide is for you.⬇️
Apologies there was a glitch in the recording system, please enjoy the last hour (8a-9a) of NMN | aired on Monday, September 22nd, 2025 on Nashville's Morning News with Dan Mandis.See omnystudio.com/listener for privacy information.
Today, I'm joined by Annette Verpillot, the visionary founder of Posture Pro, whose work is transforming how we think about alignment, movement, and brain health. Annette shares her groundbreaking brain-first approach to posture, revealing how the real root of tension, pain, and subpar movement lies not just in your muscles or bones, but deep within your nervous system. Episode Timestamps: The three sensory pillars: feet, eyes, and jaw ... 00:11:11 Parkinson's, basal ganglia, and movement improvement ... 00:09:12 How sensory input drives posture, energy, and cognition ... 00:14:46 Vagal system, childhood development, and stress ... 00:17:09 Jaw and tongue posture in child and adult health ... 00:23:22 Jaw, feet, and eye interplay: posture chain explained ... 00:28:47 Risks of dental interventions without holistic assessment ... 00:32:42 Therapeutic insoles vs. orthotics and how they work ... 00:46:08 User experience: insoles, Vivobarefoot, and performance gains ... 00:51:27 Blood pressure normalization and cardiovascular connection ... 00:55:17 Hormones, HRV, and the stress cascade ... 00:59:47 Functional Activator and jaw retraining benefits ... 01:06:11 Mouth breathing, sleep, and natural jaw development ... 01:09:00 Troubleshooting, compliance, and optimizing results ... 01:14:08 Rapid-fire: myths, habits, and overhyped tools ... 01:18:22 Our Amazing Sponsors: Puori: It's minimally processed, made from pasture-raised cows' milk, and it's tested for over 200 contaminants every single batch. Go to Puori.com/NAT and use code NAT for 20% off— it also applies to subscriptions so you'll get nearly a third off the price. Digestive Bitters by Just Thrive - One capsule before eating helps your body absorb more nutrients, ease digestion, and leave you feeling light instead of weighed down. Head over to Justthrivehealth.com/discount/NAT and use code NAT20 for 20% off. Wizard Sciences - NMN+G Rx - A scientifically formulated blend of NMN, ginsenosides from Panax ginseng, and apigenin. Together, they enhance mitochondrial function, boost NAD+ levels, and support cellular repair. Go to wizardsciences.com and look for NMN+G. Use code NAT15 at checkout to get 15% off your purchase. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group
What if your collagen cream isn't working, because your skin doesn't have the raw materials to use it?In this episode of Biohacking Beauty we reveal the missing half of most people's skincare: the internal protocol. From vitamin C as a collagen cofactor (“10x harder for your skin to build collagen without it”) to the role of omega-3s in plumping skin from the inside out, this episode lays out a step-by-step supplement strategy for real skin longevity.We break down why oral hyaluronic acid outperforms topical forms in clinical trials, why senescent cells are not the root cause of aging (just a symptom), and how bioactives like NMN, ergothioneine, and astaxanthin actually get expressed in the skin, unlike most topicals.We also discuss trends like matcha and how it outperforms coffee for skin health, and why oral senolytics like fisetin help eliminate zombie cells that drive inflammation and visible aging.You don't want to miss this one! What's Discussed:(00:39) Why Supplements Matter More Than Serums(03:38) The Foundational Skin Stack: C, D, E, Omegas, Collagen, HA(19:04) Mid-Tier Bioactives: CoQ10, Curcumin, EGCG, Astaxanthin(34:33) Advanced Longevity: NMN, Fisetin, Spermidine, Sulforaphane(43:05) Metabolomics Testing + Personalized Skin Protocols(52:46) Final Takeaways: Building a Skin Longevity RegimenFind more from Young Goose:The YouTH Firming Body Cream: Smoother arms, firmer thighs, tighter skin, powered by NAD+ and spermidine. Your body's anti-aging breakthrough →younggoose.com/bodycreamSpermidine Serums: Fewer wrinkles. More collagen. Real skin renewal at the cellular level. The serum your face has been waiting for →https://www.younggoose.com/collections/serumsUse code PODCAST10 to get 10% off your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/ Instagram: @young_goose_skincare
Today, I'm sitting down with the brilliant Dr. Joy Kong, a trailblazing clinician and scientist at the forefront of regenerative medicine and stem cell therapy. In this episode, Dr. Kong shares how she blends rigorous science with hands-on clinical practice to help people tackle everything from brain injuries and autoimmune conditions to skin aging and joint pain—often with transformative results. Products she mentions: CharaOmni facial cream Episode Timestamps: How stem cells address chronic illness ... 00:07:12 When to use IV vs. local stem cells ... 00:10:06 Types and sources: autologous, umbilical, MSCs ... 00:11:40 Why younger stem cells are superior ... 00:17:38 Emerging cell therapies: V-cells, Muse cells ... 00:20:25 Decline of stem cells with age ... 00:24:19 Stem cell therapy for neurological, organ, and autoimmune conditions ... 00:27:14 Techniques to target brain and optimize therapy ... 00:29:46 Donor screening and safety ... 00:34:41 Stem cells in healing injuries and recovery ... 00:42:28 Immune modulation and overall rejuvenation ... 00:44:56 Anti-aging protocols: frequency of IV therapy ... 00:48:36 Aesthetic uses: skin, microneedling, hair ... 00:50:08 Handling and potency of exosomes ... 00:55:01 Future of anti-aging and stem cell therapy ... 00:59:02 Legality and access in the US ... 01:03:13 Our Amazing Sponsors: Wizard Sciences - NMN+G Rx: A scientifically formulated blend of NMN, ginsenosides from Panax ginseng, and apigenin. Together, they enhance mitochondrial function, boost NAD+ levels, and support cellular repair. Go to wizardsciences.com and look for NMN+G. Use code NAT15 at checkout to get 15% off your purchase. Ultimate GI Repair by LVLUP Health - Whether you're struggling with digestive discomfort or want to strengthen your gut health, Ultimate GI Repair provides the comprehensive support your body needs to restore balance. The ingredients are unmatched! Visit https://lvluphealth.com/ and use code NAT at checkout for 20 % off. Body Cream by Young Goose - Powered by NAD+ APEX, CelVio Spermidine, and targeted peptides, this advanced formula restores cellular energy, supports collagen production, and enhances skin resilience. It clears cellular waste, improves skin texture, and deeply hydrates areas where aging shows most—like arms, legs, neck, and décolleté. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you're an existing customer. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group
Is NAD really the fountain of youth, or just another overhyped supplement trend? From energy boosts to wrinkle reduction, the excitement is everywhere, but the truth is a lot more complex. In this episode, I sit down with biomedical engineer Courtney Van Bussum to cut through the noise. Courtney brings deep expertise in cellular and longevity science,, giving her a unique perspective on both the research and the real-world clinical applications. We cover: What NAD actually is and why it's essential for energy, longevity, and healthy aging. How to know if your NAD levels are low and whether it even matters. The biggest myths and misconceptions about NAD supplements. NAD changes in pre- versus post-menopause. Why precursors like NR and NMN may backfire if deeper pathways aren't addressed. Free and low-cost ways to preserve and recycle NAD naturally. What you need to know about the molecule 1-MNA (and why it may be more important than NAD itself). Courtney Van Bussum is the COO and co-founder of Longevity Launch Labs, an innovation incubator accelerating breakthrough products and companies in cellular and longevity medicine. With a background in biomedical engineering and early experience as a strategy consultant working with both Fortune 500s and startups, Courtney brings a rare blend of scientific insight and operational execution. Before launching Longevity Launch Labs, she helped modernize operations at the Boulder Longevity Institute—one of the country's leading functional and regenerative medicine clinics. Courtney's mission is to help build parallel systems that make healthcare smarter, more proactive, and more personal—especially in the rapidly evolving world of cellular health. PAST EPISODES ON NAD THE PROBLEM WITH NAD PRECURSORS: https://podcasts.apple.com/us/podcast/88-women-in-menopause-fighting-fatigue-the-problem/id1531105768?i=1000562648714 A MORE EFFECTIVE WAY TO BOOST NAD: https://podcasts.apple.com/us/podcast/the-problem-with-nad-boosters-a-more-effective/id1531105768?i=1000523483729 WHY NR IS DANGEROUS: https://podcasts.apple.com/us/podcast/120-mitochondria-101-why-nr-is-dangerous-how-to-optimize/id1531105768?i=1000586943234 NAD 101: https://podcasts.apple.com/us/podcast/nad-101-nmn-vs-nr-the-best-and-cheapest-way-to/id1531105768?i=1000700598071 1MNA: https://1mna.com ZORA for 20% off first purchase of 1-MNA https://ohphealth.com/products/endoteliol-1mna Contact Courtney Van Bussum: Website: https://longevitylaunch.com/about-us Instagram: @cvanbuss Linkedin: https://www.linkedin.com/in/courtneyvanbussum/ Give thanks to our sponsors: Try Vitali skincare. 20% off with code ZORA here https://vitaliskincare.com Get Primeadine spermidine by Oxford Healthspan. 15% discount with code ZORA here. http://oxfordhealthspan.com/discount/ZORA Get Mitopure Urolithin A by Timeline. 20% discount with code ZORA at https://timeline.com/zora Try Suji to improve muscle 10% off with code ZORA at TrySuji.com https://trysuji.com Try OneSkin skincare with code ZORA for 15% off https://oneskin.pxf.io/c/3974954/2885171/31050 Join Biohacking Menopause before October 1, 2025 to win FLEXBEAM red light therapy device. Or save 10% with code ZORA at recharge.health https://recharge.health/product/the-flexbeam?ref=51 Join the Hack My Age community on: YouTube: https://youtube.com/@hackmyage Facebook Page: @Hack My Age Facebook Group: @Biohacking Menopause Private Women's Only Support Group: https://hackmyage.com/biohacking-menopause-membership/ Instagram: @HackMyAge Website: HackMyAge.com
Liz is answering your questions on overdoing healthy fats, strategies for hip pain, migraine management, NMN and the links between intermittent fasting and hair loss.In this episode, Liz chats through Emma's question on overdoing healthy fats and supporting bile flow, and answers Denise's questions on hip pain and managing migraines.Liz also chats through NMN and NAD+ for Carol-Anne, plus looks at whether intermittent fasting can cause hair loss.Links mentioned in the episode:Napiers Best British BittersThe Naked Pharmacy Natruflex Turmeric - save 20% with LIZLOVESWild Nutrition Food-Grown Organic Turmaforte Turmeric - save 15% with LIZLOVESCefaly migraine deviceWhy women age differently - with Dr Andrew SalzmanIs NMN safe to take? Everything you need to know about this longevity supplementYouth & Earth NMN - save 20% with LIZLOVESA Better Second Half by Liz EarleHave a question for Liz? Send a WhatsApp message or voicenote to 07518 471846, or email us at podcast@lizearlewellbeing.com for the chance to be featured on the showPlease note, on some occasions, we earn revenue if you click the links and buy the products, but we never allow this to bias our coverage and always honestly review. For more information please read our Affiliate Policy. Hosted on Acast. See acast.com/privacy for more information.
You've probably heard NAD (nicotinamide adenine dinucleotide) called the “miracle molecule” for anti-aging — but how much of that is science, and how much is hype? In this video, I break down:
Today, I'm joined by Christian Drapeau, a visionary pioneer in stem cell science and the mind behind the concept of endogenous stem cell mobilization. Christian's journey takes us from his days as a neurophysiology researcher, wrestling with questions about memory and consciousness, to a life-changing pivot into plant medicine—ultimately leading to groundbreaking work with stem cell–mobilizing botanicals like blue-green algae and sea buckthorn. In our conversation, Christian explains how the body's innate repair system slows down dramatically with age, and why many of the answers we're seeking in regenerative health might actually be within our own biology. We dive into the latest science on harnessing your body's own stem cells for healing—covering everything from muscle recovery and brain support to remarkable outcomes in heart failure, Parkinson's, and beyond. If you want to learn more about STEMREGEN, visit stemregen.co/NAT15. If you want to experience stemregen for yourself - use code: NAT15 for 15% off your order. Past episodes: Episode #93: How to Stimulate the Release of More Stem Cells in Your Body to Promote Healing Episode #232: Harnessing Your Own Stem Cells: Christian Drapeau's Unique Approach to Healing Episode Timestamps: Christian's background: brain research to plant medicine ... 00:04:12 Discovery of AFA algae and stem cell mobilization ... 00:12:40 Demystifying stem cell decline and repair with age ... 00:18:02 Concerns about running out of stem cells addressed ... 00:25:23 Exosomes vs. stem cells & synergy explained ... 00:28:43 How to prime the body for more stem cell release ... 00:32:14 Stem regen's clinical data: how many stem cells? ... 00:37:06 Athletic & muscle recovery applications ... 00:41:09 Key case studies: heart failure and Parkinson's ... 00:51:34 Limitations of “biological age” markers ... 01:00:00 Stem cells, inflammation & autoimmunity ... 01:06:11 Synergies with regenerative medicine procedures ... 01:16:21 What Christian would research with unlimited resources ... 01:26:55 Common misunderstandings about regeneration ... 01:28:07 Our Amazing Sponsors: Puori - It's minimally processed, made from pasture-raised cows' milk, and it's tested for over 200 contaminants every single batch. Go to Puori.com/NAT and use code NAT for 20% off— it also applies to subscriptions so you'll get nearly a third off the price. Tro Zzz by Troscriptions - Physician‑formulated and pharmaceutical-grade. Head to troscriptions.com, use NAT10, and get 10% off your first order. NMN+G Rx by Wizard Sciences - A scientifically formulated blend of NMN, ginsenosides from Panax ginseng, and apigenin. Together, they enhance mitochondrial function, boost NAD+ levels, and support cellular repair. Go to wizardsciences.com and look for NMN+G. Use code NAT15 at checkout to get 15% off your purchase. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group
There's a point where even the best skincare starts to feel like it's not doing enough. Serums stack up, results slow down. What no one tells you is that this might not be a product issue, it might be an energy issue. Specifically, cellular energy. NAD+.You'll learn why NAD+ declines with age, how that leads to slower healing, collagen breakdown, and pigmentation, and why traditional skincare can't keep up. We explain the science behind topical NAD+ delivery, how it compares to IVs and supplements, and why your body doesn't prioritize skin when it's low on resources.We also break down the best NAD+ precursors (NMN vs NR vs niacinamide), how to track your NAD+ status, and which ingredients actually raise NAD+ levels in skin, not just systemically. You'll discover how to combine fasting, HIIT, and smart supplementation to build an energy-optimized skincare routine that works from the inside out.Plus, we reveal the research behind NAD+ Apex™, the latest innovation from Young Goose that boosts epigenetic repair and reduces wrinkle depth by 15% in just 10 weeks.If you want your skin to keep up with your biohacking lifestyle, this episode is your protocol for recharging skin at the cellular level.What's Discussed:(00:06) When Your Skin Stops Responding—This Might Be Why(16:07) The Real Way to Raise Your NAD+ (Hint: It's Not Just Supplements)(22:01) What Happens When You Flood Your System with NAD+(37:32) Why Your NAD+ Supplement Isn't Helping Your Skin(43:52) The Skincare Ingredient Everyone's Talking About—But Most Get WrongThe YouTH Firming Body Cream: Smoother arms, firmer thighs, tighter skin, powered by NAD+ and spermidine. Your body's anti-aging breakthrough → younggoose.com/bodycreamSpermidine Serums: Fewer wrinkles. More collagen. Real skin renewal at the cellular level. The serum your face has been waiting for → https://www.younggoose.com/collections/serumsFind more from:Young GooseUse code PODCAST10 to get 10% off your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/ Instagram: @young_goose_skincare
Ready to glow like never before? In this episode of the THE WELL PODCAST, we're spilling all the tea
Learn how to slow, and even reverse, your biological age with cutting-edge science on the molecule that controls your longevity. Host Dave Asprey sits down with Dr. Leonard Guarente, an MIT PhD and one of the most respected longevity researchers in the world, to reveal how NAD+, sirtuins, and DNA methylation clocks can help you hack aging, upgrade your mitochondria, and extend your healthspan. This episode gives you the real science, proven by over 250 studies, behind supplements, nutrition, and biohacking tools that actually work for brain optimization, metabolism, and human performance. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR You'll learn why NAD+ is a master regulator of mitochondrial health, how DNA methylation clocks accurately measure biological age, and why boosting sirtuin activity improves resilience, neuroplasticity, and recovery. Dr. Guarente shares insider strategies from decades of functional medicine research, including nootropics, targeted supplements, fasting protocols, and diet adjustments from carnivore to Mediterranean that can shift your metabolism toward longevity. Dave and Dr. Guarente explore advanced biohacks like cold therapy, sleep optimization, and ketosis, plus how to balance these interventions with your genetics, lifestyle, and health goals. You'll also hear about the surprising role of homocysteine in brain aging, how to use lab testing to guide your longevity plan, and why resilience is the ultimate measure of health. You'll learn: • How emotional repression affects brain function, metabolism, and decision-making • Tools for nervous system regulation and emotional healing that drive high performance • Why most people fail without emotional intelligence and internal safety • How somatic awareness can optimize your energy, focus, and relationships • The science of fear, trauma release, and how to turn discomfort into growth • How to coach yourself out of stress, shame, and negative self-talk Whether you want to sharpen your brain, protect your heart, or upgrade your energy systems, this is a masterclass in smarter not harder biohacking for a longer, higher-performing life.Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: NAD+ supplementation, Sirtuin activation, DNA methylation clocks, Biological age testing, Mitochondrial biogenesis, Epigenetic reprogramming, Pterostilbene benefits, Nicotinamide riboside (NR), Nicotinamide mononucleotide (NMN), Homocysteine reduction, Oxidative stress repair, Superoxide dismutase (SOD) activation, Functional medicine longevity, Healthspan optimization, Resveratrol bioavailability, Menopause mitochondrial support, Phenylbutyrate and protein folding, High-fat diet longevity studies, Neurodegenerative disease biohacking, INCHIANTI aging study Thank you to our sponsors! Screenfit | Get your at-home eye training program for 40% off using code DAVE https://www.screenfit.com/dave. Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. Resources: • Elysium Website. Use code ‘UPGRADE25' for 25% off the first month of a monthly subscription to any Elysium supplement: https://www.elysiumhealth.com/ • Dave Asprey's Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Introduction to NAD & Sirtuins 0:59 — Intro 7:04 — Animal vs Human Aging Studies 10:07 — Discovery of Sirtuins 14:43 — NAD's Role in Aging 15:34 — Resveratrol vs Pterostilbene 23:13 — Timing NAD Supplementation 36:34 — Diet & Lifestyle Factors 50:05 — Elysium's Basis & Signal 1:00:03 — Future Clinical Trials 1:05:14 — Psychology of Aging & Wrap-Up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Today, I'm joined by the trailblazing Liz Parrish, a true pioneer in the world of longevity science and regenerative medicine. Liz doesn't just talk about cutting-edge gene therapies—she's the first patient to actually undergo many of them herself. In our conversation, Liz shares how her journey from stem cell advocacy to biotech innovation was fueled by a deeply personal mission: her son's diagnosis with type 1 diabetes. What we discuss: How Liz Parrish got into genetics and stem cells ... 00:06:45 Transition from childhood disease to treating aging ... 00:09:35 Difference between stem cells, gene therapy, and exosomes ... 00:14:20 Challenges in gene therapy delivery and cell reprogramming ... 00:19:22 Liz Parrish as patient zero for gene therapies ... 00:22:01 Results and lessons from Parrish's self-experimentation ... 00:23:16 Senescent cells, telomeres, and aging interventions ... 00:29:22 Evolution and progress in gene therapy ... 00:34:14 Barriers and ethics of gene therapy for rare diseases and children ... 00:36:53 Public perception and future accessibility ... 00:44:55 Affordability, scaling, and redosing gene therapies ... 00:55:00 Practical longevity habits and hormones ... 01:03:54 Our Amazing Sponsors: OraltidePro™️by Profound Health - A unique mouthwash that: Promotes growth of shrinking gums, Speeds healing of mouth & tongue, Prevents oral infections (such as gingivitis), helps with enamel remineralization, reduces bacteria growth and etching and fills slots in damaged enamel. Check out OraltidePro™️at profound-health.com and use code NAT15 for 15% off your first order. NMN+G Rx by Wizard Sciences - A scientifically formulated blend of NMN, ginsenosides from Panax ginseng, and apigenin. Together, they enhance mitochondrial function, boost NAD+ levels, and support cellular repair. Go to wizardsciences.com and look for NMN+G. Use code NAT15 at checkout to get 15% off your purchase. Fresh-Pressed Olive Oil Club: Get a full-size $39 bottle of one of the world's finest artisanal olive oils — fresh from the new harvest—for just $1. No commitment to buy anything, now or ever. Go to GetFreshLongevity.com for a free bottle and pay just $1. More from Nat: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group
A new study is challenging one of the most pervasive messages in health and fitness: the belief that 10,000 daily steps are needed to prolong life and prevent disease. Led by Professor Melody Ding at the University of Sydney and published in The Lancet, the study is the largest of its kind, analyzing data from more than 30 studies worldwide. Its findings suggest that significant health benefits may be achieved with as few as 7,000 steps a day—an attainable target for many who find 10,000 steps daunting. In this interview, Professor Ding discusses the scientific basis for rethinking our daily activity goals, how the research caught global attention, and what it means for public health recommendations moving forward. Peter Bowes speaks to Professor Ding to unpack what this shift in guidance could mean for millions tracking their steps around the world. PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarEnergyBits algae snacksA microscopic form of life that could help us age better. Use code LLAMA for a 20 percent discountDisclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.
View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Eric Verdin is a physician-scientist and the CEO of the Buck Institute for Research on Aging whose career has centered on understanding how epigenetics, metabolism, and the immune system influence the aging process. In this episode, Eric traces his scientific journey from studying viruses and histone deacetylases (HDACs) to leading aging research at the Buck Institute, offering insights into how aging impairs immune and nervous system function—including thymic shrinkage, chronic inflammation, and reduced vaccine response—and how these changes impact lifespan. He explores the metabolic underpinnings of aging, such as oxidative stress and insulin and IGF-1 signaling, and he discusses practical tools like zone 2 cardio, ketogenic diets, and GLP-1 drugs. The conversation also covers declining NAD levels with age, the roles of NAD-consuming enzymes such as sirtuins and CD38, and what current NAD-boosting strategies (like NMN, NR, and IV NAD) can and can't accomplish. Eric weighs in on promising longevity interventions including rapamycin, growth hormone for thymic regeneration, and anti-inflammatory therapies, while also examining the promise and limitations of current biological age tests and the potential of combining epigenetic, proteomic, and organ-specific metrics with wearables to guide personalized longevity care. We discuss: Eric's scientific journey from virology to the field of geroscience [2:45]; How dysfunction in the immune system and central nervous system can drive aging throughout the body [5:00]; The role of metabolism and oxidative stress in aging, and why antioxidant strategies have failed to deliver clear benefits [8:45]; Other aspects of metabolism linked to aging: mitochondrial efficiency, fuel utilization, and glucose-modulating drugs [16:30]; How inefficient glucose metabolism drives insulin, IGF-1 signaling, and accelerates aging [21:45]; The metabolic effects of GLP-1 agonists, and the need to move beyond crude metrics like BMI in favor of more precise assessments of metabolic health [27:00]; The case for immune health as a “fifth horseman” [36:00]; How the innate and adaptive immune systems work together to build immune memory [39:45]; Why vaccines lose effectiveness with age: shrinking of the thymus gland and diminished T-cell diversity [44:15]; Exploring growth hormone, thymic regeneration, and the role of exercise in slowing immune aging [48:45]; The challenges of identifying reliable biomarkers for immune function, and the potential of rapamycin analogs to enhance vaccine response in older adults [57:45]; How rapamycin's effects on the immune system vary dramatically by dosage and frequency [1:03:30]; The limitations of mouse models in aging research and the need for cautious interpretation of rapamycin's benefits in humans [1:08:15]; NAD, sirtuins, and aging: scientific promise amid commercial hype [1:15:45]; How CD38 drives age-related NAD decline, influences immune function, and may impact longevity [1:23:45]; How NMN and NR supplementation interact with CD38 and NAD metabolism, and potential risks like homocysteine elevation and one-carbon cycle depletion [1:31:00]; Intravenous NAD: limited evidence and serious risks [1:37:00]; Interleukin-11 (IL-11) as a new target in immune aging, the dual role of chronic inflammation in aging, and the need for better biomarkers to guide interventions [1:43:00]; Biological aging clocks: types of clocks, promise, major limitations, and future outlook [1:48:30]; The potential of proteomics-based aging clocks for detecting organ-specific decline and frailty [2:00:45]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube
The Silent Killer of the Mind: What You Don't Know About Alzheimer's Could Be Hurting You Already What if the path to Alzheimer's doesn't begin in your 70s—but is already unfolding in your 30s, 40s, or even earlier? In this powerful conversation with Dr. Robert Love, we expose one of the most misunderstood, underestimated health threats of our generation—Alzheimer's disease—and what you can do today to not only prevent it, but potentially reverse its early effects. I've had some of the best minds on this show, but Dr. Love stands out. He's not just brilliant—he's a world-class communicator on a mission to bring hope, tools, and clarity to one of the scariest topics out there: losing your mind. Dr. Love pulls back the curtain on the real causes of Alzheimer's—and it's not just genetics. It's inflammation. It's sugar. It's chronic stress. It's poor sleep. He explains how our modern lifestyle is sabotaging our brain health decades before symptoms appear. And here's what hit me hard: your inflammation levels at age 40 are one of the strongest predictors of your Alzheimer's risk at 70. That's not fear—that's a wake-up call. But the best part? We're not powerless. From simple lifestyle shifts to breakthrough supplements like lion's mane and curcumin, Dr. Love shows us the map to protecting the most vital organ we've got—our brain. We also dive into cutting-edge science that isn't just about prevention—it's about reversal. Dr. Love shares promising new treatments and even clinical results from his medical clinic where Alzheimer's symptoms have improved or stabilized through non-drug protocols. He gives us a first-hand account of a patient who went from disoriented and forgetful to alert, clear, and sharp—all within six months. I'm telling you, this isn't science fiction. This is the new frontier of brain health. Beyond the data and science, what really resonated with me was this: so much of what protects the brain is also what builds a better life—quality sleep, exercise, meaningful learning, low stress, good food, and strong relationships. Dr. Love reminds us that joy, curiosity, and purpose aren't just nice-to-haves—they're biological armor for your brain. And if you're young and thinking this episode doesn't apply to you? Think again. The decisions you make today will echo into the quality of your future decades. Key Takeaways: Alzheimer's starts decades before symptoms appear—your 40s matter Inflammation is one of the biggest risk factors for cognitive decline Sleep, gut health, stress, and sugar all have massive impacts on brain aging Supplements like lion's mane, curcumin, and NMN can support neurogenesis Alzheimer's symptoms can be improved or reversed with lifestyle interventions Your lifestyle is not just shaping your body—it's shaping your brain This one is a must-listen. Share it with someone you love. This information can change lives. — Max Out