Podcasts about nmn

What if the health of your brain decades from now is being shaped by what you are doing today? We tend to think about Alzheimer's and cognitive decline as problems that show up later in life, once memory starts slipping or confusion becomes noticeable. But many of the factors associated with brain decline can begin much earlier. Blood sugar, insulin resistance, sleep, inflammation, muscle mass, exercise, social connection, oral health, and even the medications you regularly take may all influence the environment your brain is aging in. This matters because brain health gives you more areas to act on than most people realize. You can pay attention to metabolic markers before they become major problems, build and preserve muscle, protect your sleep, stay socially connected, take care of your oral microbiome, and understand which emerging therapies actually have evidence behind them. The earlier you start thinking about your brain this way, the more opportunity you have to influence how well it functions later. Dr. David Perlmutter is a board-certified neurologist, six-time New York Times bestselling author, and internationally recognized expert in brain health, nutrition, and neurodegenerative disease. His latest book, Brain Defenders, explores microglia, the brain's immune cells, and how their function may influence conditions including Alzheimer's and Parkinson's. His work focuses on giving people practical ways to protect brain health through metabolism, lifestyle, and emerging neuroscience. What's Discussed: (05:51) What research suggests about slowing or even improving cognitive decline in people already diagnosed with Alzheimer's through intensive lifestyle intervention. (10:47) Why Alzheimer's should not be viewed as purely genetic and how lifestyle and metabolic health can influence risk even when genetic predispositions are present. (12:19) How loneliness and social isolation may affect brain health through stress, cortisol, oxytocin, inflammation, and changes in the brain's immune cells. (20:50) Why the biological conditions associated with cognitive decline may begin in your 40s and 50s, decades before memory problems become obvious. (30:34) How exercise supports the brain through BDNF, irisin, and other chemicals released during muscle activity, and why both cardio and strength training matter. (38:00) Why restorative sleep is an active period for memory consolidation and brain recovery, and how fragmented sleep can undermine brain health even when you spend eight hours in bed. (1:04:34) What the science currently says about NAD, NR, NMN, and IV NAD for mitochondrial function, biological aging, and cognitive health. (1:12:04) How periodontal disease, the oral microbiome, and frequent use of certain antibacterial mouthwashes may affect nitric oxide, metabolism, and long-term brain health. (1:23:05) What emerging research says about GLP-1 drugs for Parkinson's and Alzheimer's, and why using or microdosing them specifically for brain protection is still ahead of the evidence. (1:33:25) Why homocysteine and fasting insulin are two blood markers worth paying attention to when assessing metabolic and long-term brain health.   Thank You to Our Sponsors! Magic Mind: Head over to magicmind.com/jen and use code JEN at checkout. Momentous: Ready to try supplements that actually do what they claim? Head to livemomentous.com and use code JEN for 35% off your first subscription.  Therasage: Visit therasage.com and use code JEN to get 15% off your order. Your skin Prolon: Prolon is offering listeners 30% off sitewide plus a $40 bonus gift when you subscribe to their 5-Day Program! Just visit prolonlife.com/JENNIFERCOHEN and use code JENNIFERCOHEN to claim your discount and your bonus gift. Tru Niagen®: For supplements that are rigorously tested, third-party verified, and actually deliver what's on the label, head to truniagen.com Find more from Jen Cohen: Website: jennifercohen.com Instagram: @therealjencohen Books: jennifercohen.com/books Speaking: jennifercohen.com/speaking-engagements   Find more from Dr. David Perlmutter: Website: drperlmutter.com Instagram: @davidperlmutter Facebook: David Perlmutter M.D.  YouTube: @davidperlmutterMD LinkedIn: David Perlmutte, MD Book: Brain Defenders  

You've probably heard that your ovaries age 2.5x times faster than the rest of your body. I went looking for that study. It does not exist. In this episode I trace that number back to an uncited supplement company blog post, and then I give you the one that is real: ovarian aging shows up 15 to 20 years earlier than in any other tissue in your body. Your ovaries are not a fertility organ. They are the organ that sets the pace for your bones, your heart, your brain and how long you live. This is the first episode built on my four pillars: Nourish, Stack, Live and Align. I also share what is changing behind the scenes, including my practice, my planner, and where this brand is going next. Work with me one on one as a women's longevity practitioner and holistic nutritionist: https://biohackingbrittany.com/pages/clients WHAT I COVER The 2.5x ovarian aging myth and where it actually came from Why the Stanford organ aging clocks never included an ovary Senescence and fibrosis: it is not that the seeds run out, it is that the soil goes hard Why less than 2 percent of venture funding goes to women's health, and 90 percent of that goes to fertility Your full lab panel: AMH by age, antral follicle count, day 3 FSH and estradiol Why AMH does not predict whether you will get pregnant this month The birth control trap: if you are on hormonal contraception your AMH is wrong by 14 to 55 percent PMOS and why a high AMH is not extra time Cysts: functional, hemorrhagic, dermoids, and why the pill does not shrink one you already have Endometriomas, and what cystectomy actually costs your ovarian reserve Premature ovarian insufficiency, the 2024 criteria change, and why POI is not early menopause What the food research does and does not support CoQ10, melatonin, inositol, DHEA, vitamin D, NMN and omega 3, ranked by real human evidence Rapamycin, the VIBRANT trial, and ovarian tissue freezing The pelvic bowl in the classical Sanskrit text, and what it actually describes Jing, Tian Gui, and how Chinese medicine predicted the end of fertility at 49 How misalignment shows up in the body, and the guardrail I insist on Why clinical hypnosis is the woo that actually works TIMESTAMPS 08:03 The 2.5x ovarian aging myth, and what is actually true 13:23 Your ovaries are an endocrine organ, not a fertility organ 19:54 The labs to run, and AMH by age 23:55 If you are on birth control, your AMH is wrong 28:03 Cysts, dermoids, and what the pill does not do 32:24 Endometriomas and what surgery costs your ovarian reserve 34:20 Premature ovarian insufficiency 36:43 Nourish and Stack: food, CoQ10, melatonin, inositol, NMN 47:06 Rapamycin and ovarian tissue freezing 49:22 Align: the pelvic bowl, Chinese medicine, and how misalignment shows up 1:00:18 Clinical hypnosis, and my full protocol MENTIONED IN THIS EPISODE 1:1 client consults: https://biohackingbrittany.com/pages/clients The LongHer Life community, where this was recorded live: https://biohackingbrittany.com/pages/longherlife Her Stack Planner: https://biohackingbrittany.com/products/her-stack-planner Shop: https://biohackingbrittany.com/collections/shop Questions for the next live Q&A: info@biohackingbrittany.com CONNECT Instagram: https://www.instagram.com/biohackingbrittany/ Website: https://biohackingbrittany.com This episode is for education only and is not medical advice.

Accredited investors wanting to participate in our Catalina Island + Bodega Bay opportunities visit somerscapital.com/investIn this episode, Rich Somers sits down with Dr. Nathan Bryan, a nitric oxide scientist, to break down why this molecule plays such an important role in blood flow, energy, brain function, and longevity. Dr. Bryan explains his perspective on how declining nitric oxide production may contribute to brain fog, high blood pressure, erectile dysfunction, and other age-related health problems, while sharing ways people can support healthy nitric oxide production.They also dive into sleep, mouth breathing, nasal breathing, exercise, fasting, diet, NAD+, NMN, and the everyday habits that may be affecting your energy and performance. Dr. Bryan shares the routines he personally uses, why he believes blood flow is foundational to feeling and performing your best, and what people should understand about optimizing their health as they get older.Use code RICH at www.n1o1.com for 10% off our nitric oxide products.  Connect with Rich on Instagram: @rich_somers

NAD supplements, IVs, and patches are everywhere — and for a lot of women they do nothing or make things worse. Liz Roman and Becca Chilczenkowski explain why: an enzyme called CD38 consumes NAD and gets more active the more inflamed you are, so a big IV dose in an inflamed body can drive inflammation, anxiety, and autoimmune flares instead of energy. Inside: what NAD actually does, the three mitochondrial genes that decide if it works, NR vs NMN, and the 663-Dalton reason patches don't absorb. *** CONNECT:

Charles Brenner breaks down what the science actually says about NAD+, separating established findings from the claims commonly made in the longevity space. He explains why NAD levels in tissues may matter more than blood measurements, how metabolic stress, alcohol, inflammation, and other conditions can disrupt the NAD system, and how nicotinamide riboside (NR) compares with niacin, nicotinamide, and NMN. The conversation also covers research on exercise recovery, peripheral artery disease, skin health, infection, and wound healing, along with the limitations of current human evidence. Brenner explains why he advises against IV and subcutaneous NAD+, discusses concerns around NMN quality, and challenges popular sirtuin-centered theories of anti-aging while emphasizing the importance of reproducible human research. Charles Brenner is an NAD metabolism researcher whose work focuses on cellular bioenergetics, vitamin B3 biology, metabolic stress, and the pathways that regulate NAD production and utilization throughout the body. Now based at the University of Helsinki, his research has examined how the NAD system responds to conditions ranging from metabolic and liver disease to mitochondrial dysfunction, inflammation, and neurological stress. His work has also helped advance research into nicotinamide riboside as an NAD precursor and its potential applications in human health. Brenner takes an evidence-first approach to longevity science, distinguishing findings supported by controlled human studies from promising but still unproven mechanisms, animal research, and anecdotal claims.   Brenner Lab — Charles Brenner, PhD https://www.brennerlab.net/   Niagen NR Clinical Studies — Niagen Bioscience https://www.niagenbioscience.com/pages/clinical-studies   Nicotinamide Riboside for Peripheral Artery Disease — Mary M. McDermott et al. https://pubmed.ncbi.nlm.nih.gov/38871717/   This is the PAD study discussed in the episode where NR improved six-minute walking performance.   NOPARK: Nicotinamide Riboside in Early Parkinson's Disease — Haukeland University Hospital / Norwegian Research Team https://clinicaltrials.gov/study/NCT03568968   This is the 400-participant, 52-week Parkinson's trial discussed in the transcript.   Effects of Nicotinamide Riboside in Long COVID — Chao-Yi Wu, Edmarie Guzmán-Vélez, Charles Brenner et al. https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370%2825%2900567-X/fulltext   This is the Long COVID study Brenner references when discussing cognition, fatigue, sleep, and symptom recovery.   NAD+ Metabolome in Alcohol-Related Liver Disease — Richard Parker, Charles Brenner et al. https://pubmed.ncbi.nlm.nih.gov/32766477/   This is the human alcohol-related liver disease research Brenner discusses when explaining disturbed liver NAD metabolism.   Nicotinamide for Skin-Cancer Chemoprevention — Andrew C. Chen et al. https://pubmed.ncbi.nlm.nih.gov/26488693/   This is the major Australian study relevant to Brenner's discussion of oral nicotinamide and skin cancer protection.   Charles Brenner on NAD+, NR vs. NMN & NAD IVs — Dr. Rhonda Patrick / FoundMyFitness https://www.foundmyfitness.com/episodes/charles-brenner   Dr. Mike specifically references Brenner's appearance with Rhonda Patrick during the episode.   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:58 NAD Basics Explained 02:22 Cellular Role of NAD 03:21 Proven Benefits and Trials 05:24 Inflammation Markers Deep Dive 09:19 Athletes Recovery and VO2 Max 13:52 Does NAD Decline With Age 20:10 Skin NAD and UV Damage 23:40 Who Should Take NR 27:56 Niacin vs NR vs NMN 32:28 NMN Conversion and Quality 35:37 IV and Injection Warnings 42:18 Dosing Timing and Alcohol 46:50 Addiction Claims and Dream Trials 51:39 Parkinsons and Long COVID Data 55:03 Sinclair Critique Revisited 57:05 Stacking Supplements and Metformin 59:58 Wrap Up and Where to Follow   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

Charles Brenner breaks down what the science actually says about NAD+, separating established findings from the claims commonly made in the longevity space. He explains why NAD levels in tissues may matter more than blood measurements, how metabolic stress, alcohol, inflammation, and other conditions can disrupt the NAD system, and how nicotinamide riboside (NR) compares with niacin, nicotinamide, and NMN. The conversation also covers research on exercise recovery, peripheral artery disease, skin health, infection, and wound healing, along with the limitations of current human evidence. Brenner explains why he advises against IV and subcutaneous NAD+, discusses concerns around NMN quality, and challenges popular sirtuin-centered theories of anti-aging while emphasizing the importance of reproducible human research. Charles Brenner is an NAD metabolism researcher whose work focuses on cellular bioenergetics, vitamin B3 biology, metabolic stress, and the pathways that regulate NAD production and utilization throughout the body. Now based at the University of Helsinki, his research has examined how the NAD system responds to conditions ranging from metabolic and liver disease to mitochondrial dysfunction, inflammation, and neurological stress. His work has also helped advance research into nicotinamide riboside as an NAD precursor and its potential applications in human health. Brenner takes an evidence-first approach to longevity science, distinguishing findings supported by controlled human studies from promising but still unproven mechanisms, animal research, and anecdotal claims.   Brenner Lab — Charles Brenner, PhD https://www.brennerlab.net/   Niagen NR Clinical Studies — Niagen Bioscience https://www.niagenbioscience.com/pages/clinical-studies   Nicotinamide Riboside for Peripheral Artery Disease — Mary M. McDermott et al. https://pubmed.ncbi.nlm.nih.gov/38871717/   This is the PAD study discussed in the episode where NR improved six-minute walking performance.   NOPARK: Nicotinamide Riboside in Early Parkinson's Disease — Haukeland University Hospital / Norwegian Research Team https://clinicaltrials.gov/study/NCT03568968   This is the 400-participant, 52-week Parkinson's trial discussed in the transcript.   Effects of Nicotinamide Riboside in Long COVID — Chao-Yi Wu, Edmarie Guzmán-Vélez, Charles Brenner et al. https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370%2825%2900567-X/fulltext   This is the Long COVID study Brenner references when discussing cognition, fatigue, sleep, and symptom recovery.   NAD+ Metabolome in Alcohol-Related Liver Disease — Richard Parker, Charles Brenner et al. https://pubmed.ncbi.nlm.nih.gov/32766477/   This is the human alcohol-related liver disease research Brenner discusses when explaining disturbed liver NAD metabolism.   Nicotinamide for Skin-Cancer Chemoprevention — Andrew C. Chen et al. https://pubmed.ncbi.nlm.nih.gov/26488693/   This is the major Australian study relevant to Brenner's discussion of oral nicotinamide and skin cancer protection.   Charles Brenner on NAD+, NR vs. NMN & NAD IVs — Dr. Rhonda Patrick / FoundMyFitness https://www.foundmyfitness.com/episodes/charles-brenner   Dr. Mike specifically references Brenner's appearance with Rhonda Patrick during the episode.   Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:58 NAD Basics Explained 02:22 Cellular Role of NAD 03:21 Proven Benefits and Trials 05:24 Inflammation Markers Deep Dive 09:19 Athletes Recovery and VO2 Max 13:52 Does NAD Decline With Age 20:10 Skin NAD and UV Damage 23:40 Who Should Take NR 27:56 Niacin vs NR vs NMN 32:28 NMN Conversion and Quality 35:37 IV and Injection Warnings 42:18 Dosing Timing and Alcohol 46:50 Addiction Claims and Dream Trials 51:39 Parkinsons and Long COVID Data 55:03 Sinclair Critique Revisited 57:05 Stacking Supplements and Metformin 59:58 Wrap Up and Where to Follow   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Allen Bookatz, and Jodi Duval explore one of the most overlooked causes of declining cellular energy: the structural breakdown of the mitochondrial membrane. While many people invest in premium longevity supplements like NAD+, NMN, and CoQ10 to improve energy production, emerging research suggests these compounds cannot overcome a damaged mitochondrial membrane. The team explains how age-related phosphatidylcholine depletion weakens the mitochondrial lipid bilayer, causing proton leakage, oxidative stress, and reduced ATP production, even when the biochemical machinery appears intact. From membrane lipidomics and clinical metabolomics to phosphatidylcholine replacement and methylation support, this discussion reframes mitochondrial health through the lens of structural integrity rather than simply adding more fuel. Join us as we delve into: The Leaky Mitochondria Problem: Why declining phosphatidylcholine causes proton leaks that reduce ATP production and accelerate mitochondrial aging. Why NAD+, NMN & CoQ10 Sometimes Fail: How expensive mitochondrial supplements cannot restore energy when the mitochondrial membrane itself has become structurally compromised. Pathogenesis vs. Salutogenesis: Why Health Optimization Medicine focuses on building the biology of health instead of simply preventing disease. Clinical Metabolomics & Membrane Lipidomics: How measuring functional biomarkers provides deeper insight into cellular health than conventional blood tests alone. Phosphatidylcholine Replacement Therapy: Why rebuilding mitochondrial membranes with pharmaceutical-grade phosphatidylcholine, methyl donors, and chronobiology may improve bioenergetics. The Prevention Paradigm Shift: Why optimizing membrane integrity may become a foundational strategy for supporting healthy aging and cellular resilience. This episode is for you if: You are taking NAD+, NMN, CoQ10, or other mitochondrial supplements but still struggle with fatigue or poor recovery. You want to understand why mitochondrial membrane health may be more important than simply increasing energy substrates. You are interested in clinical metabolomics, membrane lipidomics, and the future of precision lifestyle medicine. You want to learn how phosphatidylcholine and methylation support contribute to healthy mitochondrial function. You can also find this episode on… YouTube: Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

Welcome to Quick Hits — where we bring you the most impactful moments from past episodes in under 15 minutes. Today's clip comes from one of our most replayed conversations. If you want the full episode, check the link in the description below. Listen to the full episode Listen on iTunes What actually works when it comes to anti-aging skincare, and what is simply expensive marketing in a very attractive bottle? In this quick hits clip Karen sits down with Amitay Eshel, co-founder and CEO of Young Goose. Amitay explains why effective anti-aging skincare is about much more than moisturizing the surface of the skin. Healthy, resilient skin depends on cellular energy, mitochondrial function, ingredient stability, internal hydration, damage repair and the skin's ability to respond to stress. We also explore how common skincare ingredients such as vitamin C, hyaluronic acid, retinol, NAD, NMN, collagen and spermidine actually work, along with why stronger treatments are not always better. If your bathroom cabinet is overflowing with products but your skin is still dry, dull, irritated or changing rapidly during menopause, this conversation will help you understand what your skin may actually need. In The Full Episode, You'll Learn How vitamin C and hyaluronic acid influence skin rejuvenation Why the stability of vitamin C matters as much as the ingredient itself Why topical skincare cannot fully compensate for poor internal hydration How mitochondrial health affects skin quality and muscle strength How cellular energy influences the skin's ability to repair damage Why stronger concentrations of retinol are not always more effective How skincare ingredients can degrade before they ever reach your skin Why encapsulation is used to protect sensitive ingredients such as NMN How collagen and NAD work differently when ingested versus applied topically Why spermidine is being studied and used in advanced skincare formulas How menopause affects collagen, hydration, pigmentation and skin resilience Why personalized skincare is more effective than following a generic routine When laser resurfacing may be helpful Why frequent aggressive treatments may damage the skin barrier How targeted skincare may improve wrinkles, pigmentation and visible aging   Get 10% off your order with Young Goose here.  Sponsors Get 20% off your Cozy Earth Bed Sheet with coupon code HORMONES     Are you in perimenopause or postmenopause and struggling with symptoms—but not getting the support you deserve? At Midlife Solutions, we specialize in hormone optimization for women in midlife. Our all-female clinical team offers telehealth care across all 50 U.S. states, with the ability to prescribe bioidentical estrogen, progesterone, testosterone, and thyroid medication.   Book your FREE Hormone Discovery Call Find out what's really driving your symptoms and what your next best steps are.   Visit the website: https://karenmartel.com   Shop the Midlife Solutions Store Over-the-counter bioidentical hormone creams and oils — no prescription needed. Including: • Progesterone • Estrogen Face Cream • Vaginal Moisturizer and more!   Take the Hormone Quiz Discover hidden hormone imbalances that could be driving your symptoms. Get personalized results (and yes, they may surprise you).   Women's Peptide Weight Loss Program Clinically guided, hormone-aware weight loss for midlife women.   Midlife RESET HRT Program A complete, supportive approach to hormone replacement therapy in midlife.   Your host: Karen Martel Certified Hormone Specialist, Transformational Nutrition Coach, & Weight Loss Expert   Karen's Facebook Karen's Instagram

How does a skin scientist evaluate a worth-it product? What ingredients are too good to be true? This week, we're partnering with our friends at Parëva Beauty to learn the answers to these questions directly from the founder Smitha Rao — a scientist who's spent nearly two decades formulating over 200 products for brands like StriVectin and Olaplex before launching her own line. Smitha breaks down what's actually happening with buzzy ingredients like exosomes and NAD+, what “clinically proven” really means, and the informed difference between anti-aging and skin longevity.Tune in to hear:What biotech skincare actually means, and why Smitha says “the future is biology, not chemistry”How exosomes work to help skin regenerate its own collagen — and why not all exosome technologies are created equalNAD+ and NMN, decoded: why you keep seeing these phrases pop-up on skincare labelsThe questions to ask before trusting any “clinically proven” claim The biggest mistake even savvy INCI-label readers make when building a routine, according to SmithaSmitha's take on the ingredients having a moment that she's most skeptical ofAn inside look at Parëva's latest launch, the GFP12 Collagen Eye Serum

Most of us assume that losing energy, struggling to sleep and taking longer to recover are simply inevitable parts of getting older.But what if they're not?Executive performance coach Drew Griesel believes many people are paying what he calls The Hidden Performance Tax - a slow, almost invisible decline in energy, focus and resilience that develops over years and eventually feels "normal."In this interview with Peter Bowes he explains why improving healthspan should come before pursuing longevity, why sleep quality may be the single most important driver of performance, and why the fundamentals - movement, nutrition, hydration and recovery - still matter more than the latest biohacks. Drew's YouTube channel is:https://www.youtube.com/@PrimalWellnessCoaching----DISCLOSURE: This podcast is supported by affiliate arrangements with a select number of companies. We have arranged discounts on certain products and receive a small commission on sales. The income helps to cover production costs and ensures that our interviews remain free for all to listen. Visit our LIVE LONG SHOP for more details: PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin.  DISCOUNTS AVAILABLE NOWSupport the showThe Live Long podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

What if living a longer, healthier life isn't about finding the next supplement or wellness trend, but about making better choices every day?Holistic health educator Emma Magnolia shares her approach to intentional living, exploring how strength training, hydration, sleep, simple daily routines and consistency can help support healthy aging.Rather than chasing quick fixes, this conversation focuses on practical habits that almost anyone can adopt to build a healthier future.Emma Magnolia is the founder of emmawellness.com ----DISCLOSURE: This podcast is supported by affiliate arrangements with a select number of companies. We have arranged discounts on certain products and receive a small commission on sales. The income helps to cover production costs and ensures that our interviews remain free for all to listen. Visit our LIVE LONG SHOP for more details: PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarEnergyBits algae snacksA microscopic form of life that could help us age better. Use code LLAMA for a 20 percent discountPartiQlar supplementsEnhance your wellness journey with pure single ingredients. 15% DISCOUNT - use code: MASTERAGING15SiPhox Health home blood testingMeasure 17 critical blood biomarkers from home. Get a 20% discount with code LLAMA Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the showThe Live Long podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Dr. Ted Lain and Dr. Patti Farris cut through the hype around today's most popular longevity supplements.They dig into the real (and often surprisingly thin) clinical evidence behind NAD precursors like NMN and nicotinamide riboside, the gut-derived compound Urolithin A, creatine for brain and muscle health, multivitamins and the buzzy Cosmos trial, and off-label rapamycin use.Along the way, they talk through epigenetic clocks, precision medicine, why mouse studies don't always translate to humans, and why "TBD" might be the most honest verdict on longevity science right now.Plus, details on their upcoming Science of Skin Longevity Summit, February 19–21, 2027, in Scottsdale, Arizona.Disclaimer: This podcast is not intended to provide diagnosis, treatment, or medical advice. Content provided in this podcast is for educational purposes only. Please consult with a physician regarding any health-related diagnosis or treatment.

Stripe was in talks to buy OpenRouter for as much as $10B while still chasing PayPal. Midjourney bought astrology app Co-Star, Meta launched Facebook Verified and a standalone Seller app, and Nvidia and Microsoft defended open-weight AI. Sources: Stripe is in talks to acquire OpenRouter, which helps developers use AI models and could fetch ~$10B; PitchBook: OpenRouter was valued at $1.3B in May (WSJ) Sources: Stripe and Advent's unsolicited $53B PayPal offer, backed by ~$50B in committed bank financing, would create a payments giant processing ~$3.7T annually; PayPal has not responded (Reuters) Midjourney bought astrology app Co-Star, which uses AI to offer personalized advice, in the spring and is building its first standalone image-generation app (Bloomberg) Meta launches Facebook Verified, a free program it says will verify that users are real humans by analyzing a facial recognition selfie and assigning badges (Engadget) Meta launches Seller, a free standalone app version of Facebook Marketplace; Seller includes AI features that scan photos to fill out listings automatically (NYT) Meta, Nvidia, Microsoft, a16z, and others sign a letter defending open-source AI; Jensen Huang, in his first X post, says open models strengthen cybersecurity (The Information) Signatories including Palantir avoid naming China or Moonshot in the open-weight letter, framing it instead around US AI leadership being judged by a strong open ecosystem, not one frontier model (Bloomberg) Longreads Meet All The Middle Aged Women Who Don't Exist: AI-generated wellness influencers, all gorgeous and all "57", are selling NMN supplements to women over 40 (Charlotte's Book) Big US pizza delivery chains are struggling as DoorDash and Uber Eats give independent pizzerias greater market access, erasing the tech moat chains once had (FT) Subscribe to the ad-free feed. Learn more about your ad choices. Visit megaphone.fm/adchoices

Want to live longer?What if getting sick wasn't inevitable?Longevity physician Dr. Gregory Burzynski joins us to explain how modern medicine is shifting from treating disease to preventing it before it starts.We discuss the cutting-edge tests, imaging, genetics, peptides, supplements, hormone therapy, and lifestyle habits that could dramatically improve not just how long you live, but how well you live.We also tackle the biggest misconceptions about aging, why waiting until symptoms appear may be costing you years of healthy life, and which longevity strategies are actually worth your money.In this episode we cover:• The blood tests every woman should know about• Whole-body imaging and early cancer detection• Gene testing vs. epigenetics• Creatine, Vitamin D, fish oil & NMN• HRT and Peptides• Cold plunges, fasting, saunas & wearables• The future of longevity medicineIf you enjoy the episode, don't forget to subscribe, leave a review, and share it with someone who wants to stay healthy for decades to come.Dr. Gregory Burzynski's Links:resTOR longevity Clinic HCM, Houston Concierge Medicine(00:01:03) Why longevity is changing the future of medicine(00:04:00) Why Dr. Gregory Burzynski thinks dying should be optional.(00:09:46) When should you start thinking about longevity?(00:14:00) Do you have to be wealthy to live longer?(00:16:20) The best tests to catch disease before symptoms appear(00:21:28) Genetics vs. epigenetics—what's the difference?(00:24:00) Can we turn back the clock? (00:31:01) Inflammation, supplements & the biggest deficiencies doctors see(00:36:30) Rapamycin, NMN & the future of anti-aging medicine(00:47:38) Peptide use and availability(00:50:22) Lightning Round: Fasting, cold plunges, saunas & alcohol(00:54:41) HRT, testosterone & wearable health trackers(00:59:43) Where to hear more from Dr. Gregory BurzynskiWant to leave the TTSL Podcast a voicemail? We love your questions and adore hearing from you. https://www.speakpipe.com/TheThickThighsSaveLivesPodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠The CVG Nation app, for ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠iPhone⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠The CVG Nation app, for Android⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Our ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Fitness FB Group⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Thick Thighs Save Lives Workout Programs⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Constantly Varied Gear's ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Workout Leggings⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Disclaimer: The information shared in this podcast is for educational and informational purposes only and is not intended as medical advice. The views expressed are those of the hosts and guests and should not be used as a substitute for professional medical diagnosis, treatment, or advice. Always consult your physician or qualified healthcare provider before making changes to your diet, exercise routine, medications, supplements, or healthcare plan.Statements regarding supplements and wellness products have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease.Guest opinions are their own and do not necessarily reflect the views of the hosts or producers.

Discover the truth about population-wide NAD+ optimization with Dr. Jin-Xiong She from Jinfinity Precision Medicine. We break down the clinical flaws behind the recent Janssen and Houtkooper human blood study claiming NAD levels do not decline with age or lifestyle habits. Learn how ethnicity, health status, NMN vs. NR synergies, and high-dose niacin vascular inflammation impact intracellular biomarkers, and discover the true optimal blood reference target for healthy aging.Does human NAD+ actually decline with age, and do popular precursors like NMN or NR work for everyone? In this episode of Modern Healthspan, we sit down with clinical frameworks pioneer Dr. Jin-Xiong She, founder of Jinfinity Precision Medicine, to dissect recent human trial publications. Dr. She critiques a controversial recent paper asserting that blood NAD+ remains static across age groups, exposing its narrow testing intervals and misleading over-generalizations. Drawing from thousands of independent patient datasets, Dr. She details the sharp, non-linear NAD drop off that occurs between ages 20 and 30, while revealing the hidden impacts that ethnicity and background health status have on your baseline cellular metrics. We also explore the optimal human blood target range, shifting from a baseline of 40 µmol to a clinical sweet spot between 55 and 80 µmol, and highlight the surprising cardiovascular inflammation risks linked to over-supplementing with high-dose niacin

Join The Circle (use code PODCAST): ➡️ https://holplus.co/circle/Why are you always tired, even after getting enough sleep? If you wake up exhausted, struggle with brain fog, rely on caffeine, or lose your energy halfway through the day, the problem may begin inside your cells.In this solo episode of hol+, Dr. Taz explains why your body may be “biologically bankrupt,” meaning it is using energy faster than it can rebuild it. She breaks down three hidden causes of low energy: mitochondria that are not producing enough power, declining NAD levels, and old “zombie cells” that remain in the body and increase inflammation.You'll also learn simple ways to support your energy, including better sleep, moderate exercise, stress management, intermittent fasting, and nutrients such as magnesium, B vitamins, CoQ10, and quercetin.In this episode:Why you may still feel tired after sleepingHow your cells create energyThe connection between fatigue and brain fogWhat mitochondrial dysfunction meansWhy NAD matters for energy and cellular repairWhat “zombie cells” areHow inflammation drains your energyWhy caffeine and sugar only provide a temporary boostHow sleep and exercise help rebuild cellular energyPractical ways to stop running on emptyLearn more about hol+ and schedule an appointment:https://holplus.co/Listen to more episodes of the hol+ podcast:https://holplus.co/podcast/If you know someone who is always tired or struggling with low energy, share this episode with them. Subscribe for new episodes about hormones, gut health, inflammation, healthy aging, and whole-person healing every week.Stay Connected:Dr. Taz: https://www.instagram.com/drtazmd/Hol+: https://www.instagram.com/liveholplus/Hol+ Show: https://www.instagram.com/holplushow/Subscribe to the audio podcast: https://holplus.transistor.fm/subscribeSubscribe to the video podcast: https://www.youtube.com/@HolPlusShow/podcastsGet your copy of ➡️ The Hormone ShiftChapters00:00 Why Your Energy Never Seems to Last00:48 Chi, Prana and the Body's Energy01:49 Why Our Cells Are Running on Empty02:54 What Is Biological Bankruptcy?04:01 The 3 Pillars of Cellular Energy05:08 How Mitochondria Produce Energy06:24 Oxidative Stress and Mitochondrial Damage07:39 How Mitochondrial Dysfunction Accelerates Aging08:29 Chronic Fatigue, Long COVID and Cellular Energy09:48 Your Fatigue Has an Address10:14 Join The Circle11:00 Why NAD Is Essential for Cellular Repair11:44 Why NAD Levels Decline12:13 The NAD and Inflammation Cycle13:41 What Are Senescent or “Zombie” Cells?15:22 How Zombie Cells Drive Inflammaging15:57 What Fatigue May Reveal About Your Health16:35 Cellular Energy, Focus and ADHD17:24 How to Reverse Biological Bankruptcy17:46 Sleep and Mitochondrial Repair18:15 Exercise and Mitochondrial Renewal18:41 CoQ10, Magnesium and B Vitamins19:04 Rebuilding NAD Levels19:39 How to Clear Out Zombie Cells19:59 Intermittent Fasting and Autophagy20:13 Cortisol and Mitochondrial Dysfunction21:02 Final TakeawaysProduced by https://ClipGrowth.com (Producer: Pat Gostek)

Modern life asks less and less of our bodies, while placing ever greater demands on our minds. We move less, sleep poorly and fill every spare moment with stimulation—often without realizing the long-term consequences.Oscar Trelles explores the connections between recovery, resilience and the way we age. His work—through the wellness and performance company Breathing Flame—focuses on helping people better understand the conditions that shape health and long-term wellbeing.In his forthcoming book, The Human OS Manual, he argues that a longer, healthier life depends less on isolated interventions and more on the rhythms and routines that shape our days.So have we lost touch with the conditions that help us thrive—and what would it take to restore them?----DISCLOSURE: This podcast is supported by affiliate arrangements with a select number of companies. We have arranged discounts on certain products and receive a small commission on sales. The income helps to cover production costs and ensures that our interviews remain free for all to listen. Visit our LIVE LONG SHOP for more details: PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarEnergyBits algae snacksA microscopic form of life that could help us age better. Use code LLAMA for a 20 percent discountDisclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the showThe Live Long podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

In this special episode, Dr. Josh Axe sits down with his wife, Dr. Chelsea Axe, to share the family longevity blueprint they actually live by at home. Together, they break down their daily routines for nutrition, strength training, supplements, faith, beauty, and raising healthy kids in a world full of unhealthy habits.  Chelsea shares why muscle mass, high-protein meals, consistency, and targeted testing have become central to their family's health philosophy. They also discuss real challenges, including their daughter's severe dust-mite allergy, inflamed tonsils and adenoids, SLIT therapy, and why their approach is now simple: test, don't guess. Uncover what's really going on in your body with advanced biomarker testing for hormones, thyroid, and metabolism— plus a 1-hour consultation with a Senior Health Advisor! →  http://mybloodwork.com Thank you to our sponsors! Sunlighten Sauna: https://get.sunlighten.com/axepodcast Manukora Manuka Honey: https://manukora.com/axe Caraway Home: carawayhome.com/drjoshaxe (Use code DRJOSHAXE) for an exclusive discount Watch The Dr. Josh Axe Show every Monday & Thursday on YouTube: https://www.youtube.com/@drjoshaxe?sub_confirmation=1

A Note from James:I've been obsessed with anti-aging and longevity science for a long time. I've had many longevity researchers on the podcast, but this episode feels different because something we've been discussing for years has now moved into human trials.David Sinclair first came on the show in 2019, when his book Lifespan was published. He's a professor of genetics at Harvard Medical School, and that first conversation changed how I lived. I started experimenting with intermittent fasting, paid much more attention to sleep, and began researching many of the supplements and lifestyle changes he discussed.But the most important idea David talked about wasn't a supplement. It was the possibility of reversing cellular age using Yamanaka factors—genes that can reset the instructions cells use to function. At the time, nobody knew whether this could be done safely without causing cancer or making cells lose their identities.Now, a therapy based on three of those factors has entered its first human clinical trial. The initial target is age-related damage to the optic nerve, including open-angle glaucoma and non-arteritic anterior ischemic optic neuropathy. The trial is designed primarily to evaluate safety, but researchers will also measure visual function.David explains how this technology worked in mice and nonhuman primates, why the eye was chosen as the first organ, and how the same approach might eventually be applied to the liver, lungs, joints, skin, and brain.We also cover the practical questions people always ask him: NMN, NAD, metformin, berberine, testosterone, growth hormone, diet, fasting, sleep, exercise, and what David himself has started—or stopped—taking.This is still experimental science. Nobody yet knows whether the animal results will translate into meaningful benefits for humans. But for the first time, researchers are beginning to test that question directly.About Lifespan: Dr. David Sinclair founded Lifespan to deliver clear, science-backed health insights that help people live longer, more vibrant lives.He's now building the world's largest community dedicated to extending human longevity well beyond today's limits. Join early access at lifespan.com. New episodes of Lifespan with Dr. David Sinclair -- the #1 health and wellness podcast in its first season -- are now available on YouTube, Spotify, Apple Podcasts, and Lifespan.com.Episode Description:For years, longevity researchers have looked for ways to slow the biological processes associated with aging. Dr. David Sinclair and his collaborators are now testing a more ambitious possibility: whether damaged human cells can be restored to a younger, more functional state.The experimental therapy, ER-100, uses controlled expression of three transcription factors—OCT4, SOX2, and KLF4, collectively known as OSK. These are three of the four Yamanaka factors originally used to transform adult cells into pluripotent stem cells.Turning on all four factors can erase too much of a cell's identity and has produced tumors and fatal outcomes in animal experiments. Sinclair's team found that removing one factor, c-MYC, allowed cells to regain younger patterns of gene expression without completely returning to a stem-cell state.In preclinical studies, OSK restored youthful epigenetic patterns, promoted optic-nerve regeneration, and reversed vision loss in mouse models. Life Biosciences, a company Sinclair co-founded, has now moved the technology into a first-in-human Phase 1 trial involving people with open-angle glaucoma or non-arteritic anterior ischemic optic neuropathy.David explains how the therapy is delivered directly into the eye and activated using doxycycline, allowing clinicians to control when and for how long the genes are expressed. He also describes the development path that could follow if the treatment proves safe, including therapies targeting the liver and other organs, as well as future medicines that may reproduce similar effects without gene delivery.The conversation then turns to interventions available today. David distinguishes between promising research and claims that have moved ahead of the evidence, discussing NMN, injected NAD, growth hormone, testosterone, taurine, nattokinase, metformin, berberine, and nootropics.Throughout the episode, he emphasizes that no supplement has been shown to reproduce the effects researchers are attempting to achieve through partial epigenetic reprogramming—and that many of the most dramatic claims circulating online remain unsupported.Editorial Note:ER-100 is an investigational therapy. Authorization to begin a clinical trial does not mean the treatment has been proven safe or effective, nor has it been approved for clinical use.The Phase 1 study is primarily evaluating safety and tolerability, with additional measurements of visual function. Results from mice and nonhuman primates do not establish that the therapy will restore vision or reverse biological aging in people.The discussion of supplements, prescription medications, hormones, and lifestyle practices reflects the speakers' personal views and interpretation of the research. It should not be treated as individualized medical advice. Prescription drugs, hormones, supplements, and experimental longevity treatments should be discussed with an appropriately qualified healthcare professional.What You'll Learn:How partial epigenetic reprogramming differs from completely resetting a cell into a stem cell.Why researchers selected three Yamanaka factors—OCT4, SOX2, and KLF4—instead of using all four.What ER-100 is designed to do and why the first human trial focuses on the optic nerve.How doxycycline acts as an external switch controlling when the therapeutic genes are expressed.What Phase 1 researchers will measure and what would need to happen before ER-100 could become an approved treatment.Why the eye provides a useful starting point for testing cellular rejuvenation.What animal studies suggest about restoring vision, memory, liver function, joints, and skin.Why delivering rejuvenation therapies throughout the body is more difficult than treating one localized organ.The difference between oral NMN supplementation and intravenous or subcutaneous NAD.What current research does—and does not—show about growth hormone, testosterone, taurine, metformin, and berberine.Why muscle, exercise, sleep, diet, glucose regulation, and inflammation remain important even if rejuvenation therapies eventually succeed.How Sinclair's laboratory is searching for pills and small molecules that could mimic epigenetic reprogramming without gene therapy.Timestamped Chapters:[04:53] The First Human Trial Begins David discusses ER-100, FDA authorization, and the treatment of open-angle glaucoma and ischemic optic neuropathy.[06:52] What Are the Yamanaka Factors?How reprogramming genes can reset cellular instructions—and why using all four factors can be dangerous.[08:56] Reversing Vision Loss and Memory Problems in AnimalsDavid describes studies involving the eyes, brain, skin, kidneys, liver, and age-related cognitive decline.[10:09] Why Four Factors Can Cause CancerThe difference between restoring youthful function and erasing a cell's identity completely.[10:54] The Three-Gene BreakthroughHow Sinclair's student Yuancheng Lu persisted through years of failure and identified the OSK combination.[12:03] Pulsing the Genes vs. Leaving Them ActivatedEarlier four-factor experiments required intermittent activation, while OSK showed a different safety profile in animal eyes.[13:36] The Doxycycline Safety SwitchHow clinicians may use an antibiotic to activate and deactivate the therapy after it has been delivered.[14:51] Treating the Cause Instead of the SymptomsDavid argues that restoring younger tissue function could allow the body to repair damage associated with age-related disease.[16:02] Why the Trial Starts With the EyeLocalized delivery reduces systemic exposure and makes visual changes easier to observe and measure.[16:50] Can the Therapy Reach the Brain and the Rest of the Body?The challenges of distributing gene-based treatments evenly across organs and through the blood-brain barrier.[18:25] What the Phase 1 Trial Will MeasureSafety, tolerability, visual function, and the possibility of an accelerated development path.[20:36] Expanding Beyond GlaucomaWhy each organ may require a different delivery vehicle—and how the liver could become another early target.[21:38] How Shinya Yamanaka Found the Original Four FactorsThe trial-and-error process that turned adult cells into induced pluripotent stem cells.[22:38] How ER-100 Is DeliveredDavid explains the OSK genes, the AAV delivery system, doxycycline activation, and why manufacturing is expensive.[25:21] When Could the Treatment Become Available?David gives his most optimistic development timeline and discusses parallel programs targeting other organs.[27:31] NMN, NAD, Sirtuins, and the Information Theory of AgingHow declining NAD levels may affect cellular defenses and the regulation of gene expression.[31:34] Oral NMN vs. Injected NADWhy David believes oral supplementation currently has more rigorous evidence than NAD injections.[32:20] Longevity Misinformation OnlineDavid explains why he is restarting his show and warns against confident recommendations unsupported by research.[32:41] Growth Hormone and LifespanWhy growth hormone may improve certain functions but has not been shown to slow aging or extend human life.[34:05] Testosterone, Muscle Mass, and Healthy AgingPotential benefits for maintaining muscle—and why testosterone alone should not be considered a longevity treatment.[36:01] Taurine, Nattokinase, and Changing Your MindWhy David stopped taking taurine regularly and what prompted his interest in nattokinase.[37:30] David's Current Diet and His 86-Year-Old FatherLower meat and cheese consumption, little alcohol, exercise, supplements, and tracking inflammation through biomarkers.[39:33] James's Longevity RoutineLimited processed sugar, intermittent fasting, reduced meat and alcohol, and prioritizing eight hours of sleep.[40:07] Why Sleep Cleans the BrainThe relationship between sleep, waste removal, protein accumulation, cognition, and dementia risk.[40:33] Metformin as a Possible Longevity DrugWhy a medication developed for type 2 diabetes remains central to aging research.[41:41] Berberine and Mitochondrial FunctionWhat clinical studies suggest about glucose regulation and why David sometimes alternates berberine with metformin.[43:10] Modafinil, Adderall, and NootropicsPossible short-term benefits for focus weighed against uncertainty about long-term consequences.[43:43] What Comes After the Eye Trial?Potential applications involving the liver, lungs, kidneys, joints, brain, and other age-related conditions.[45:14] Can Rejuvenation Make Skin Look Younger?David describes unpublished work involving human skin, wound healing, and orally delivered compounds in mice.[46:17] Beyond Gene Therapy: A Rejuvenation PillHow AI and chemical screening may help reproduce the effects of early embryonic reprogramming more cheaply and simply.[47:31] When Could Chemical Reprogramming Reach Humans?David discusses the preclinical safety work and the uncertainty surrounding future human studies.[48:11] The Lifespan Community and FoundationDavid introduces his new show, longevity community, and support for scientific research.Additional Resources:ER-100 Phase 1 Trial — ClinicalTrials.govOfficial registration for the first-in-human study evaluating ER-100 in open-angle glaucoma and non-arteritic anterior ischemic optic neuropathy.Life Biosciences: FDA Clearance for ER-100The company's January 2026 announcement that the FDA cleared its Investigational New Drug application.Life Biosciences: First Participant DosedThe June 2026 announcement marking the start of dosing in the Phase 1 trial.“Reprogramming to Recover Youthful Epigenetic Information and Restore Vision” — NatureThe 2020 mouse study reporting that OSK expression restored youthful epigenetic patterns, promoted nerve regeneration, and reversed vision loss.The Sinclair Lab at Harvard Medical SchoolResearch, publications, laboratory members, and information about David's work on the biology of aging.Lifespan: Why We Age—and Why We Don't Have ToDavid Sinclair and Matthew LaPlante's 2019 book about the biology of aging and emerging longevity research.LifespanDavid's longevity show, research magazine, community, and information about the Lifespan Foundation.NMN Human-Trial Review — PubMedA review of the safety evidence and proposed effects of nicotinamide mononucleotide in human clinical studies.NMN and Physical Performance — PubMedA systematic review examining randomized trials of NMN and physical-performance measurements.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

One in eight Americans is already on a GLP-1. Within the next 12 to 24 months, that number could jump to one in two. And most people have no idea where these drugs actually come from — or what's really in them. In this episode of Cut to the Chase: with Gregg Goldfarb, Gregg sits down with Fabian Calvo — longevity industry insider, pharmaceutical supply chain strategist, and CEO of WellSync — to pull back the curtain on the global drug supply chain, the real science behind peptides and testosterone therapy, and what it actually takes to live a longer, healthier life. If you've ever taken a medication, wondered about GLP-1s, or heard about peptides and had no idea where to start — this episode is essential listening.   Join Gregg and Fabian on Cut to the Chase as they discuss: Why 95% of America's generic drugs are manufactured in China and India — and what that means for national security  What a peptide actually is, why GLP-1s like Ozempic and Wegovy are just the beginning, and how to know if your source is safe The truth about testosterone therapy — why decades of fear were based on bad science, and what the latest research actually shows What NAD does, what rapamycin is, and which longevity treatments have real science behind them Why the U.S. spends trillion a year on chronic disease — and what blue zone cultures are doing differently How pharmacy benefit managers are driving up drug prices for everyday Americans What medicine will look like in 10 years — and the three things you can do right now to be ready   KEY MOMENTS 00:00 — GLP-1s, peptides, and why this conversation matters right now 01:30 — How the pharmaceutical supply chain actually works 03:00 — Why 95% of generic drugs come from China and India 05:00 — What is a peptide? The simplest explanation you'll hear 07:30 — BPC-157, the "Wolverine stack," and what the science says 10:00 — Fabian's background: from real estate to pharmaceutical supply chain CEO 13:00 — The broken U.S. healthcare model and the chronic disease epidemic 16:00 — Female hormone therapy: the NIH study that was completely debunked 19:00 — Testosterone therapy: what's changed, what's FDA-approved, and who it's for 22:00 — NAD, NMN, and Dr. David Sinclair's research explained 25:00 — Rapamycin, Easter Island, and the most exciting longevity drug you've never heard of 29:00 — Blue zones, Japan, and why community might be the best longevity medicine 33:00 — America's drug supply at geopolitical risk — what's being done 37:00 — Why Americans pay more for drugs than any other country 40:00 — Pharmacy benefit managers explained — and why they're a problem 44:00 — What medicine looks like in 10 years and the three pillars to start with today    Fabian Calvo is a longevity industry insider and pharmaceutical supply chain strategist with over a decade of experience at the intersection of drug regulation, compound pharmacy networks, and healthcare access. He is the founder of New Care Pharmaceuticals, an FDA-compliant importer of active pharmaceutical ingredients, and CEO and board member of WellSync, a tech infrastructure company whose platform Boom RX has been placed in over 10,000 medical clinics, med spas, and aesthetics practices across the United States. Fabian has met with FDA leadership including former FDA head Dr. Marty Makary, and has traveled extensively to China and India to vet pharmaceutical sourcing. His mission is to help people live healthier, longer lives through proactive, data-driven healthcare.   The resources mentioned in this episode are: Learn more about WellSync and the Boom RX platform, currently active in over 10,000 medical clinics across the U.S.: wellsync.com Learn more about New Care Pharmaceuticals and FDA-compliant pharmaceutical ingredient sourcing. Research BPC-157 and its studied benefits for gut health, tendon repair, and inflammation — referenced in this episode as a widely researched peptide. Learn more about rapamycin and its longevity research, originally discovered on Easter Island (Rapa Nui) and now being studied for its mTOR-inhibiting and anti-aging properties. Research NAD and NMN supplementation and the work of Harvard PhD Dr. David Sinclair on mitochondrial function and aging. Consult your provider about a comprehensive blood panel that includes hormone levels — Fabian's recommended first step before starting any therapy. Learn more about GLP-1 medications including Ozempic and Wegovy and the compound pharmacy landscape for access and sourcing.     Want to hear more health, legal, and lifestyle conversations that matter? Subscribe to Cut to the Chase: with Gregg Goldfarb. Want to stay updated on our latest podcasts? Subscribe to Cut to the Chase: Podcast Newsletter for monthly podcast releases and the latest legal news: https://lp.constantcontactpages.com/sl/KqDopgE

NMN has become a familiar name on supplement shelves, marketed as a tool for slowing aging and boosting energy. Here's a closer look at what it is and what the research shows.What Is NMN, and Why Does It Matter?Nicotinamide mononucleotide (NMN) is a molecule the body uses to build nicotinamide adenine dinucleotide (NAD+), a coenzyme essential to nearly every cell. NAD+ powers cellular energy production and acts as a signaling molecule, regulating DNA repair, immune responses, and epigenetic changes — the chemical switches that turn genes on and off. The body can also make NAD+ from tryptophan, vitamin B3, and nicotinamide riboside (NR), but NMN converts into NAD+ rapidly once ingested.NAD+ levels decline naturally with age, and that decline tracks with several hallmarks of aging. Human skin studies show a roughly 70 percent drop in NAD+ alongside rising oxidative DNA damage; liver tissue shows about a 30 percent loss between ages 45 and 60; and brain imaging shows a 10 to 25 percent decline from adolescence to old age. Because NAD+ supports energy metabolism, cardiovascular and neurological protection, DNA repair, and anti-inflammatory activity, NMN supplementation has become a key strategy for offsetting this decline.If you would like to learn more about the show, please feel free to visit ourwebsite at foreveryoungradioshow.com where you can listen to past shows and read fantastic articles.We have a great show planned today and will talk about the popularity of NMN & NAD. We will cover why and the science behind it.  To help us unpack all the research and studies we have, Dr. Stengler joined us today.In addition to authoring 30 books on health and several best-sellers such as “The Natural Physician's Healing Therapies,” “Prescription for Natural Cures,” “Prescription for Drug Alternatives,” and “Outside the Box Cancer Therapies,” Dr. Stengler has been published in several peer-reviewed medical journals such as The International Journal of Family & Community Medicine, Endocrinology & Metabolism International Journal, and Journal of Nutritional Health & Food Engineering.Dr. Stengler's, NMD. The newest book is called, The Holistic Guide to Gut Health.A comprehensive yet accessible approach to healing leaky gut and the many uncomfortable symptoms it causes. Dr Stengler is also the founder of The Stengler Center for Integrative Medicine.Learn more about Dr. Mark StenglerLearn more about Emerald Labs NMN+Red Orange Complex

What if aging isn't simply your body “wearing out”… but your body losing the ability to repair itself? In this episode, Dr. Andrew Salzman joins Dr. Josh Axe to explain why chronic inflammation, leaky gut, and depleted NAD may quietly drain the very energy your cells need to heal, think, move, and survive. Uncover what's really going on in your body with advanced biomarker testing for hormones, thyroid, and metabolism— plus a 1-hour consultation with a Senior Health Advisor! →  http://mybloodwork.com Thank you to our sponsors! Sunlighten Sauna: https://get.sunlighten.com/axepodcast Manukora Manuka Honey: https://manukora.com/axe Caraway Home: carawayhome.com/drjoshaxe (Use code DRJOSHAXE) for an exclusive discount Watch The Dr. Josh Axe Show every Monday & Thursday on YouTube: https://www.youtube.com/@drjoshaxe?sub_confirmation=1

Sugar is woven into our culture as a reward, a comfort and a celebration. But for some people, the relationship with food becomes far more complicated - and potentially life-threatening.Broadcaster and journalist Phil Williams has written with extraordinary candour about living with binge eating disorder and the hidden toll it took on his physical and mental health. In this Live Long conversation, he describes the shame, self-loathing and health scares that finally forced him to confront his addiction.It's a powerful reminder that living well isn't simply about adding years to life, but understanding the behaviours that can take those years away.This episode includes strong language.Phil on Substack: I'm sorry to have to tell you this, but you have a binge eating disorderIf you or someone you know is struggling with an eating disorder, help is available.UK: BEAT – the UK's eating disorder charityUK: NHS Eating DisordersUS: National Eating Disorders Association (NEDA)US: National Association of Anorexia Nervosa and Associated Disorders (ANAD)US: National Alliance for Eating Disorders----DISCLOSURE: This podcast is supported by affiliate arrangements with a select number of companies. We have arranged discounts on certain products and receive a small commission on sales. The income helps to cover production costs and ensures that our interviews remain free for all to listen. Visit our LIVE LONG SHOP for more details: PartiQlar supplementsEnhance your wellness journey with PartiQlar supplements. No magic formulas, just pure single ingredients, like NMN, L-Glutathione, Spermidine, Resveratrol, TMG and Quercetin. Get a 15% discount with the code MASTERAGING15 at PartiQlarSupport the showThe Live Long podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Hosts: Ed Jones (Owner – Nutrition World) & Clint Powell A variety of topics all related to living a healthy life Presented by: Nutrition World www.nutritionw.com Broadcasting from the Nooga Dentistry Studio www.noogadentistry.com Production of: Whitfield Media Group www.vitalhealthradio.com Title: Peptides, AMPK, and Other Supplements for Weight Loss.  [0:00:00] Headlines, Glucosamine & Alzheimer's, and Study Skepticism Ed recaps last week's episode about truly high-quality eggs and how to tell if eggs are nutritious Mentions Kristy (“chicken whisperer”) and that her eggs are sold at Nutrition World. Ed addresses a national headline claiming glucosamine may accelerate Alzheimer's. Explains it was an observational study based on medical records, not a controlled trial. People who start glucosamine often already have joint pain, inflammation, or cognitive decline. This creates confounding factors (correlation ≠ causation). Even broad AI-style review of research finds little credibility for the idea that glucosamine worsens Alzheimer's and notes that some data suggest potential benefit. Clint and Ed discuss: How people often change multiple habits at once when they get sick (diet, supplements, etc.). The importance of baseline data (bloodwork, journaling) before judging if changes work [0:13:29] Guest Elisha: What Peptides Are & How They Can Assist Weight Loss Elisha from Nutrition World is introduced. Ed recounts his history with weight-loss supplements: Heavy use of ephedra in the '80s and '90s: effective but with side effects (nervousness, blood pressure, insomnia). Ephedra was eventually banned; Ed largely stopped promoting weight-loss pills, focusing instead on lifestyle, macros, and exercise. Ed admits he dismissed Ancient Nutrition's new Active Peptides at first, assuming it was a label trend riding on the buzzword “peptides.” Reports strong positive feedback from real customers, including many who are not heavy supplement users but want help with appetite and weight. Elisha  explains peptides with a “pearl necklace” analogy: A full necklace = protein. Individual pearls = amino acids. Small segments of the chain = peptides, which act like signals or “text messages” in the body. Distinguishes nutritional peptides (like in this product) from therapeutic/medical peptides (e.g., GLP‑1 drugs). Describes DNF‑10, the peptide in Active Peptides: A three‑amino‑acid chain isolated from baker's yeast (Saccharomyces cerevisiae). Modulates appetite‑related hormones: Ghrelin (“hunger hormone”) – DNF‑10 helps reduce ghrelin signaling so you feel less hungry. CCK (cholecystokinin) (“fullness hormone”) – DNF‑10 helps increase CCK, making you feel full/satisfied sooner. Elisha's personal experience: Used it to help lose a few pounds before her wedding and to control cravings after a carb‑heavy honeymoon in Italy. Reports feeling less snacky in the afternoons despite the tempting snacks at Nutrition World. Notes customers are consistently “wowed” by the effect on appetite Product forms and dosing: Powder in flavors like guava grapefruit and chocolate (which she says tastes like brownie). Capsules: typically 2 per day. Can be mixed with: Ancient Nutrition's A2 protein powder after lunch. Or simply with water. [0:24:35]  AMPK, Berberine & Metabolism Support Products Alicia introduces Life Extension AMPK Metabolic Activator: AMPK is described as a master cellular switch in every cell — like the light switch in your house showing you what needs cleaning. Supports cellular cleanup and improves handling of belly/visceral fat, the dangerous fat around organs. Typical study protocol: 12–16 weeks (3–4 months) for notable changes. Usually 1 capsule per day. Ed references Dr. David Sinclair and the role of AMPK (and NMN) in longevity, noting strong safety when aiming to restore normal function, not push extremes. Berberine: Also activates AMPK. Mimics some effects of metformin: supports blood sugar balance and metabolic health. Very safe overall, though some experience GI upset; Ed notes finding a brand that minimized stomach issues. Nutrition World pharmacist Dr. Curt Dearing frequently recommends it. Life Seasons Metabolism Formula: Designed to boost resting metabolic rate rather than affect satiety. Key ingredients mentioned: Green tea (thermogenesis) Cayenne pepper (metabolic “furnace”) Theobromine (mild stimulant for energy without jitters) Theanine (calming) Cacao (hormonal and metabolic support) Green coffee bean (via chlorogenic acid; supports liver and moderates sugar release, especially in fasting). Ed recalls the Dr. Oz–era fad around green coffee bean and notes that while it was overhyped, it does have real, modest benefits when used correctly and not as a “magic pill.” Ed describes his own experience: Training for the Chattanooga Fitness bodybuilding event. Cut calories by ~40% for the first time at age almost 69, but only lost about 7 pounds, illustrating slower metabolism with age. Elisha emphasizes: These products are tools, not replacements for macros, exercise, and lifestyle. Goal is to raise resting metabolic rate and support what diet and training are already doing. Elisha notes peptides are fine in the evening (non‑stimulating) but the Metabolism formula should be used earlier in the day due to its stimulating ingredients. [0:37:39] Aging, Eye Strain Ed reframes healthy aging: Less about reaching extreme ages (e.g., 120+) and more about strength, clarity, mobility, and energy in the years you do have. Notes concepts like a “heartbeat quota”—a rough idea that we have a finite number of heartbeats. Discusses modern eye strain from constant near‑focus screens: Historically, humans mostly focused on distant objects. Screen use reduces blinking from about 15 times/min to 5–7 times/min, leading to dry, strained eyes. Recommends the 20‑20‑20 rule: every 20 minutes, look 20 feet away for 20 seconds. Mentions lutein and zeaxanthin from green vegetables as supportive eye nutrients. [0:40:51] Teflon, & philosophy on chemicals Ed shares a household tip: He uses green, non‑toxic stainless steel cookware (360 Cookware) but scrambled eggs stick badly. His sister suggested Dawn Powerwash, which worked exceptionally well on the pan. Clint notes he uses non‑stick pans where food slides right out. Ed warns: Many non‑stick pans (e.g., classic Teflon) can contain “forever chemicals”, potentially harming hormones and long‑term health. Philosophical tension: Show is generally pro‑“green pharmacy” and low‑chemical living, but Ed acknowledges sometimes selective use of effective products (like Dawn Powerwash) can be very helpful if used sparingly and thoughtfully. [0:42:15]  Intermittent fasting & hair loss Ed shares findings from a new research study linking intermittent fasting with increased hair loss: During fasting, the body shifts from glucose to fat as fuel. Hair follicle stem cells strongly prefer glucose; forcing them to rely on fat can stress or damage them. Fasting may flood follicles with toxic fatty acids, especially in the presence of widespread seed‑oil consumption (canola, generic “vegetable oils,” etc.). Reinforces Ed's long‑standing reservations about intermittent fasting: Risk of insufficient protein, leading to muscle loss and higher mortality. Harder to build muscle within a restricted eating window. Adds this hair loss risk as another factor against aggressive fasting for many people. [0:44:59] Tinnitus & diet Study highlights dietary links for tinnitus (ringing in the ears): Higher fruit consumption correlates with lower odds of developing tinnitus. Butter and legumes appeared to calm tinnitus symptoms. MSG and aspartame/Nutrasweet can worsen tinnitus by overstimulating nerves. [0:46:00] Safer bug repellents Ed discusses concerns with DEET: Effective but not ideal for frequent or heavy use, especially on children and over large skin areas. Introduces picaridin (he pronounces it like “Picardian”): 20% picaridin spray is comparable to DEET for repelling mosquitoes and ticks. Has a better safety profile, less damaging to fabrics, and is Ed's top chemical alternative to DEET. Natural/green options: Lemon eucalyptus oil and similar formulas can repel mosquitoes for up to 6 hours. Nutrition World carries options like Trek and “Extra Strength Tick Repellent,” which Ed's family uses directly on skin, especially for his grandkids. [0:54:08] Resistance Training, Longevity, Mindset on Medicine vs. Nature Ed cites a study from the British Journal of Sports Medicine: 90–119 minutes per week of resistance training associated with: 13% lower all‑cause mortality. 19% lower cardiovascular mortality. 27% lower mortality from neurological diseases, particularly dementia‑related. Reiterates: Exercise is the most reliable “elixir” of longevity. Emphasizes that quality of life and cognitive health are at least as important as adding years. Ed quotes Andrew Kaufman, MD, who advocates: Strong belief in natural healing and the body's innate ability to self‑regulate. Skepticism toward new pharmaceuticals and product trends. “Your body is always working in service to your healing.” Ed adds his own nuance: There is an important role for short‑term pharmaceuticals, surgeries, and acute interventions when life‑saving. But defaulting to nature and lifestyle first, with drugs as Plan B, is his guiding model. Clint points out that practitioners who have worked both in conventional and integrative spaces can often offer the best balanced guidance, understanding both toolkits without being dogmatic. [0:56:15]  Final reflections & closing Ed summarizes: The world can be divided into “learners and non‑learners,” and listeners of the show are very much in the “learner” camp. The show's mission is to give practical, immediately usable health strategies that often aren't emphasized in conventional appointments. Clint highlights: We can't control everything (genetics, some disease), but having things we can control (diet, movement, sleep, supplements, environment) gives confidence and calm. Ed emphasizes the phrase: “Genes load the gun; lifestyle pulls the trigger.” Good habits can keep risky genes silent much longer The post Radio Show / Podcast – June 21, 2026 first appeared on Vital Health Radio.

You don't die of old age. You die of the diseases aging causes — and Dr. Sandra Kaufmann says we can fight back.In this episode of Transparent with Tina, longevity physician Dr. Sandra Kaufmann breaks down the science of aging in a way that actually makes sense. From the 7 Tenets of Aging to cutting-edge tools like exosomes, NAD+, NMN, and senolytics — this conversation will change how you think about your body, your health, and your future.We go deep on:

What if the secret to overcoming chronic fatigue, brain fog, and cellular aging lies within your mitochondria? In this episode of The Better Life, host Dr. Mary Ann Pinkston sits down with international speaker, researcher, and cellular medicine expert Dr. Gordon Crozier from the Crozier Clinic. Together, they dive deep beneath the surface of traditional medicine to explore how integrative, evidence-based approaches can truly revitalize your health. If you’ve been slamming methylated B vitamins for MTHFR mutations but still feel completely exhausted, this conversation is the missing piece of your puzzle. What You’ll Learn in This Episode: The Truth About NAD+: Why this vital cellular coenzyme is essential for DNA repair, intense detoxification, and mitochondrial energy. NAD+ vs. Precursors: The difference between raw IV NAD+ (and why it causes nausea) versus cutting-edge precursors like NMN and True Niagen. The Magic of Methylene Blue: How this powerful antiviral compound works in concert with NAD+ to supercharge the electron transport chain—and why you must take structured breaks from it. Deep-Dive Methylation: Why methylation goes far beyond MTHFR, impacting hormone breakdown, breast and prostate cancer prevention, and neurodegenerative risks. Natural NAD+ Boosters: How everyday habits like proper weight management, targeted protein intake, and consistent exercise naturally elevate your levels. The Danger of "Supplement Overload": Why less is often more, and the hidden risks of buying non-third-party tested supplements off the shelf. Important Safety Note: Dr. Crozier explains why compounding quality matters and highlights critical contraindications for Methylene Blue, including SSRIs (Serotonin Syndrome risk) and G6PD deficiencies. Connect with the Experts: Find Dr. Gordon Crozier: Learn more about his practice, research, and social media at CrozierClinic.com. Find Dr. Mary Ann Pinkston: Access past episodes, resources, and links discussed in today's show at drpbetterlife.com. See omnystudio.com/listener for privacy information.

NAD is everywhere right now: supplements, injections, podcast topics, longevity clinics. And I'll be honest, when something gets this trendy, I get skeptical. But NAD is different. This is actually something I've been watching closely for nearly 25 years, and the science has finally caught up.Here's what most people don't realize: the exhaustion, the brain fog, the slower recovery you've been chalking up to "just getting older"? That's often your NAD levels in freefall, and it's happening earlier than you think.On this episode, I'm breaking down what NAD actually does inside your cells, why most supplements on the market are quietly failing you, and what I looked for when I finally designed my own formula — Gundry MD Elevate NAD+. I spent years waiting to make one until I could develop an NAD supplement that delivered you real results. On this episode, you'll learn: What the "second baseman" is, and why it is the most important player in your cellular health (3:09)All about the French Paradox and its connection to NAD research (4:32)What fasting and strength training have in common that no one talks about (6:15)The dirty secret about most NMN supplements on the market (7:35)3 reasons your NAD gets depleted (and what a well-designed formula like Gundry MD Elevate NAD+ actually does about it) (15:25)The checklist I use to evaluate any NAD supplement (17:41)What age should you actually start thinking about NAD support (12:21)What real NAD support looks like in practice (hear my personal story) (10:57)A special thank you for being part of our podcast family, use code PODCAST25 for 25% off your purchase of my brand-new NAD supplement. Code valid until 4/9/27 on all regular priced items. My Account and subscription price excluded. Can not be combined with other offers. Does not apply to bundles, devices and digital products.For full show notes and transcript: https://drgundry.com/Gundry-MD-NAD-SupplementThank you to our sponsors! Check them out: Take your water to the next level with the AquaTru water purifier, go to aquatruwater.com and enter code “GUNDRY20” at checkout for 20% off.Get $20 off your first box plus a free year of protein, like sirloin or ribeye at ButcherBox.com/GUNDRY.Visit Juvent.com/GUNDRY and use code GUNDRY at checkout to get an extra $300 off your Juvent Micro-Impact Platform.Get a quote today at Progressive.com.Shop my new air filter, Homekind Total Air! Use code CLEANAIR for 10% off. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Chad Hyams and Bob Stewart host Mike Linares, an expert in health and longevity. Delve into aging, fatigue, brain fog, and the science behind reversing the aging process. Explore lifestyle strategies and supplements like NMN and NAD. Mike discusses the benefits and limitations of popular health trends such as cold plunges, saunas, and red light therapy, providing practical advice on living healthier. Discover the potential of fasting, glutathione, and stem cells. Mike Linares, a successful YouTube educator, shares insights from his work with Longevity Farms and Rejuvenate Peptides. Connect with Mike https://simplenursing.com/author/mike-linares/ https://www.instagram.com/mike.linares/?hl=en ---------- Connect with the hosts: •    Ben Kinney: https://www.BenKinney.com/ •    Bob Stewart: https://www.linkedin.com/in/activebob •    Chad Hyams: https://ChadHyams.com/ •    Book one of our co-hosts for your next event: https://WinMakeGive.com/speakers/   More ways to connect: •    Join our Facebook group at www.facebook.com/groups/winmakegive •     Sign up for our weekly newsletter: https://WinMakeGive.com/sign-up •     Explore the Win Make Give Podcast Network: https://WinMakeGive.com/   Part of the Win Make Give Podcast Network

Send us Fan MailFTV; She didn't feel contractions, and she still delivered two healthy babies. That single fact opens a door most of us never think about: what happens when the usual pregnancy and postpartum “signals” are quiet or missing, and the system is built for people who feel everything?I have the pleasure of talking to  Ryan Rae Harbuck. She is a swim coach, mom of two, and author of *When I Grow Up, I Want to Be a Chair*. Ryan is paralysed from around the rib cage down, and she walks us through the real logistics of a paraplegic pregnancy and wheelchair motherhood, from shifting centre of gravity and harder transfers to swelling, circulation issues, and the constant question of labour detection.Her first birth begins with a shocking discovery at a routine appointment: she's already in active labour with no clear internal alarm. After delivery, a postpartum tear and MRSA infection reveal another critical risk when pain isn't available as a warning sign.We also dig into what actually helps: relentless self-advocacy in health care, planning that still leaves room for surprise.And she mentions some adaptive parenting gear that makes daily life safer and easier, including baby-wearing, a FreeWheel-style wheelchair attachment, and an accessible crib design.  You can find Ryan every where.Her website Instagram and FacebookYou can find her book at all major retailers, including Amazon, by going to this page and selecting your favourite retailer.In the news this week  I talk about an experience one of my clients had with NMN. I have addressed NMN supplementation before and my client's experience highlights the issue I raised before about dosage. Here is a little article where you can find some more information on rising oestrogen levels.As always; HPNB only has 5 billing cycles. So this means that you not only get 3 months FREE access, no obligation! BUT, if you decide you want to do the rest of the program, after only 5 months of paying $10/£8 a month you now get FREE LIFE TIME ACCESS! That's $50 max spend, in case you were wondering. Though I'm not terribly active on  Instagram and Facebook you can follow us there. I am however active on Threads so find me there! And, of course, you can always find us on our YouTube channel if you like your podcast in video form :) Visit healthypostnatalbody.com and get 3 months completely FREE access. No sales, no commitment, no BS. Email peter@healthypostnatalbody.com if you have any questions, comments or want to suggest a guest/topic           Playing us out this week;  All over you by VAULTZ 

Andrew Huberman takes it. Peter Attia has been talking about it for years. Every serious longevity researcher has an opinion on it. And by age 40 to 60, your levels have already dropped by 50%. NAD+ is one of the most important molecules in your body. It powers energy production in every cell, repairs DNA damage every single day, and activates the cellular pathways that regulate aging, inflammation, and metabolic function. The biology is not hype. But the way most people are taking it right now almost guarantees it is doing nothing. And Dr. G is done watching people waste their money on the wrong molecule in the wrong form at the wrong dose. In this episode, you will learn:  • Why you cannot raise your cellular NAD+ levels by swallowing NAD+ directly, what happens to the molecule in your digestive tract, and the precursors that actually work  • The clinical research on NR vs NMN, which one has more published human trial data, which one the longevity research community is most excited about, and why sublingual delivery changes everything  • Why the serving sizes on most NAD+ labels are set to make the price look reasonable rather than match the research, and what a therapeutic dose actually looks like Plus the specific brands Dr. G uses and trusts, and how to test your own intracellular NAD+ levels before and after to see if your stack is actually working. Timestamps: 0:00 - NAD+ Drops 50% Between Ages 40 and 60 — Here's Why That Matters  1:37 - What NAD+ Actually Does in Every Cell of Your Body  2:15 - The Fatigue, DNA Damage & Accelerated Aging Tied to NAD+ Decline  3:39 - The Real Question: Is What You're Buying Actually Doing Anything?  4:09 - Why You Cannot Raise NAD+ by Swallowing NAD+ Directly  4:59 - The Three Precursors That Actually Work: Niacin, NR & NMN Explained  6:49 - NR vs. NMN: What the Latest 2026 Research Actually Says  7:34 - Why Most NAD+ Products on the Market Are Dangerously Underdosed  9:06 - Who Should Actually Be Taking NAD+ Precursors (And Who Can Wait)  10:14 - Dr. G's Clinical Recommendation: Sublingual NMN, Proper Dosing & Resveratrol Stacking 11:28 - How to Test Your NAD+ Levels Before and After Supplementing  11:42 - The Brands Dr. G Recommends Learn more about your ad choices. Visit megaphone.fm/adchoices

Drag by 2 PM? In this Supplement Ingredient Series episode, Nurse Doza breaks down NAD+, the coenzyme your cells use to make energy (ATP), and why levels dip with age and stress. He explains how NAD+ injections at home through SHED's provider-guided telehealth program offer a convenient way to support steady all-day energy, sharper focus, and less brain fog. Try it with code DOZA40 for 40% off. Featured Partner: SHED SHED is a telehealth provider that ships physician-reviewed NAD+ at-home injection kits, so you can keep a consistent NAD+ routine without booking a clinic IV drip — exactly the kind of convenient, repeatable protocol Nurse Doza describes in this episode. Always follow the dosing and technique guidance from your SHED provider.

Roughly 25% to 30% of the population carries slow variants in the MAOA or COMT genes, the two enzymes responsible for clearing adrenaline, dopamine, and serotonin from the brain.For these individuals, common polyphenols marketed for inflammation and longevity, including curcumin, act as weak MAOA inhibitors that further slow neurotransmitter breakdown. The result is a quiet buildup of stimulation that gets misread as anxiety, insomnia, or unexplained agitation, with no obvious connection to the supplement bottle that caused it.In this episode of Biohacking Beauty, Dr. Tyler Panzner joins us to translate exactly this kind of pharmacological nuance into protocols people can actually use. He is a PhD pharmacologist with research in neuropharmacology and breast cancer metastasis, and has worked with over 900 clients, particularly highly sensitive people, to identify their genetic weak points and remove the supplements quietly working against them.If you are stacking longevity supplements, feel wired without explanation, or want to understand why your body responds differently than the marketing promises, this episode is for you.What's Discussed:03:15 Why supplements are the "Wild West" of holistic health.08:42 The hidden problem with curcumin, resveratrol, and EGCG for sensitive people.15:30 The four gas pedals of the brain: adrenaline, histamine, glutamate, and sulfur.22:18 Stress vs. anxiety and how the brain builds narratives around physiological activation.29:45 Why your meditation practice may be failing because of a supplement.37:20 NMN degradation, the NAMPT "toll booth," and topical vs. systemic delivery.46:08 The future of multi-omics testing and personalized protocols.Find more from Young Goose:Use code PODCAST10 to get 10% off your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% off at younggoose.comInstagram: @young_goose_skincareFind more from Dr. Tyler Panzner:Website: drtylerpanzner.comInstagram: @drtylerpanznerFacebook: Dr. Tyler PanznerLinkedin: Tyler Panzner, Ph.D.YouTube: @drtylerpanznerFREE Guides: drtylerpanzner.com/free-guides1:1 Genetic Coaching: https://drtylerpanzner.com/startyourjourneyQuieting an Overactive Mind Webinar: https://overstimulated.drtylerpanzner.com/webinar-registration-page

NAD+ has become the longevity industry's favorite molecule, sold as as a supplement and as a four-hour IV that promises sharper thinking, more energy, and slower aging. But a new 2026 paper complicates the very story it was built on. In this episode, Jeff breaks down what NAD+ actually is, what the human trials really show, and why the gap between a $40 oral supplement and a $1,200 IV drip matters more than the marketing admits. You'll learn about: What NAD+ does in the body and why it got tied to aging The new research questioning whether NAD+ truly declines with age Oral NR and NMN versus IV infusions, and what the evidence supports The risks rarely mentioned, including the cancer question Why the saline, B vitamins, and forced rest may explain how good people feel This episode is for anyone weighing NAD+, longevity supplements, or an IV drip, and who wants to tell real science from wellness hype first. This episode was made possible by: LMNT: Get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at drinklmnt.com/commune. Stemregen: Get 20% off your first order at stemregen.co/commune with the code COMMUNEPOD Vivobarefoot: Try Vivobarefoot risk-free with a 100-day return guarantee, and get 15% off your order at ⁠vivobarefoot.com/commune⁠. Stripes: Visit stripesbeauty.com and use the code COMMUNE20 for 20% off our entire product line. Sunlighten: Visit sunlighten.com/commune Up to 2,100 off saunas and $50 off Red Light Products with code “COMMUNE”

How CD38, PARP, and Leaky Gut Are Destroying Your NAD Levels | Dr. Andrew Salzman Your NAD is being drained by two hidden enzymes, your gut may be the starting point of every aging process in your body, and creatine does something to your mitochondria that has nothing to do with muscle. This episode rewrites what you thought you knew about longevity, anti-aging biology, and how your body actually produces and delivers energy at the cellular level. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Explore all of Wonderfeel's products at: getwonderfeel.com/dave They are gifting a complimentary 7-day Youngr™ supply (mini pouch) with every order across any of their products. The code will be DAVE, and the campaign will be active through June 6th. Host Dave Asprey sits down with Dr. Andrew Salzman, a physician, inventor, and biomedical entrepreneur with more than 30 years of experience in drug discovery and development. An alumnus of Harvard Medical School, Yale University, and Columbia University, Dr. Salzman has authored more than 170 scientific publications and holds 50 patents. He invented the original clinical-stage PARP-1 inhibitor, leading to the world's first clinical treatment for raising NAD levels and fighting cancers caused by the BRCA1 and BRCA2 genes. Genentech licensed his breakthrough technology for $600 million. His research into gastrointestinal microbiota, autoimmune disease, oxidative stress, and mitochondrial ATP production now forms the foundation of how millions of patients get treated worldwide. Dr. Salzman names the two biggest NAD drains in your body, CD38 and PARP, and explains why taking NMN or NR alone is like filling a bathtub with the drain wide open. He breaks down the formulation science behind pairing NAD precursors with CD38 blockers like hydroxytyrosol alongside PARP-reducing antioxidants like ergothioneine, and delivers a paradigm-shifting explanation of creatine as an energy distribution network inside your cells. Rather than a simple muscle supplement, creatine acts as a high-speed ATP shuttle that carries energy from your mitochondria to the precise location and moment your brain, gut, and heart need it most. You'll Learn: Why NAD declines with age and which two enzymes are primarily responsible for draining it How CD38 rises with inflammation rather than NAD levels, and what that means for your supplement strategy Why creatine is one of the most underrated anti-aging and brain optimization supplements available How creatine functions as a spatial and temporal energy delivery network for your brain, gut, and heart Why the gut may be the origin point of the entire aging process and how that cascade unfolds decade by decade How leaky gut drives systemic inflammation, crashes NAD, and accelerates biological aging throughout the body What controls tight junction integrity and how ATP, butyrate, creatine, and fasting all play a role Why most creatine supplements fail to absorb properly and what to look for in a high-quality source How to rebuild your microbiome in three to four weeks through diet alone, without antibiotics Why walking immediately after a meal may be doing more harm than good to your gut lining Thank you to our sponsors! - Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. - KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off - Pique | Go to Piquelife.com/dave for 20% off. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. Andrew Salzman, NAD depletion, CD38 inhibition, PARP inhibition, NMN supplements, creatine ATP shuttle, leaky gut aging, tight junction integrity, inflammaging, lipopolysaccharide gut, flagellin toxin, butyrate gut healing, ergothioneine, hydroxytyrosol, peroxynitrite, superoxide mitochondria, creatine energy distribution, gut origin of aging, NAD bathtub analogy, BRCA PARP inhibitor, Wonderfeel, creatine monohydrate, intestinal permeability, microbiome butyrate, selective digestive decontamination, TMAO nitric oxide Resources: • Explore all of Wonderfeel's products at: getwonderfeel.com/dave • Order Youngr™: getwonderfeel.com/dave• Order ChocoCreatin™: getwonderfeel.com/dave• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 01:12 – Introduction & BRCA Background 02:19 – DNA Damage & PARP 04:38 – Free Radicals & Oxidative Stress 11:37 – NAD & Antioxidant Defense 12:34 – CD38 & NAD Depletion 23:31 – The Gut-Aging Hypothesis 30:05 – ATP, Creatine & Energy Distribution 36:41 – Creatine as Energy Shuttle 51:09 – Microbiome & Gut Repair 59:21 – TMAO & Nitric Oxide Interference 1:03:52 – Flagellin & Gut Inflammation Research 1:09:45 – FDA & Pharmaceutical Incentives 1:16:05 – Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

“What if the exhaustion, brain fog, low libido, and metabolic changes women experience in midlife are actually rooted in a deeper cellular energy crisis?” In this episode, Dr. Mariza sits down with Dr. Andrew Salzman — physician, inventor, biochemical engineer, and Chief Scientific Officer of Wonderfeel — to unpack the powerful connection between NAD, mitochondrial health, inflammation, ovarian aging, gut integrity, nitric oxide, and the dramatic energy shifts women experience during perimenopause and menopause. Dr. Salzman explains why menopause represents a major biological inflection point for women and how declining NAD levels may be contributing to fatigue, brain fog, poor recovery, metabolic dysfunction, sleep issues, reduced stress resilience, cardiovascular changes, and shifts in sexual health. Together, they explore the evolutionary role of menopause, why ovarian senescence accelerates aging pathways, how inflammation and the enzyme CD38 rapidly deplete NAD stores, and why the gut microbiome may be one of the biggest drivers of inflammation and energy decline in modern women. They also dive into nitric oxide production, cardiovascular health, the brain's dependence on NAD for sleep and cognitive function, and why ingredients like NMN and creatine are gaining attention for supporting healthy aging and resilience in midlife. If you've ever looked in the mirror and thought, “I don't feel like myself anymore,” this conversation will help connect the dots between your symptoms, your mitochondria, and your long-term vitality. ANDREW SALZMAN Dr. Andrew Salzman is a physician, inventor, biochemical engineer, and the Chief Scientific Officer of Wonderfeel. With more than 30 years of experience in drug discovery and development, over 170 scientific publications, and more than 50 patents, Dr. Salzman has spent decades studying aging biology, inflammation, cellular resilience, nitric oxide signaling, and mitochondrial health IN THIS EPISODE Why menopause is a major biological inflection point for women How declining NAD levels impact energy, metabolism, sleep, and brain function Why CD38 accelerates inflammation and NAD depletion during aging The surprising connection between gut health, inflammation, and menopause symptoms How estrogen decline contributes to leaky gut and systemic inflammation Why nitric oxide is essential for circulation, libido, cardiovascular health, and cognition The role of NAD in circadian rhythm, sleep quality, and stress resilience Why NMN and creatine are gaining attention for healthy aging and vitality QUOTES“Menopause will happen, but the question is: how do we maintain vibrancy and resilience through it?” “NAD is the common currency that drives energy throughout the body.” “The gut is the foundational driver of inflammation as we age.” “Without NADPH, you don't have nitric oxide production.” RESOURCES MENTIONED Subscribe and Save $15 on Wonderfeel Youngr™ NMN: https://tidd.ly/4rPnckS Use code ENERGIZED and get 30% off on your first BATCH order https://hellobatch.com/ENERGIZED Order my newest book: The Perimenopause Revolution https://peri-revolution.com/ Wonderfeel Website Wonderfeel Instagram Wonderfeel YouTube RELATED EPISODES  741: Estrogen, Gut Health, Mitochondria, and Cardiovascular Health: What Changes In Perimenopause with Dr. Siobhan Mitchel 691: The Fertility Crisis No One Talks About: Why Your Health Today Impacts Future Generations with Dr. Ann Shippy 717: “I Don't Feel Like Myself Anymore”: The Mental & Emotional Reality of Perimenopause 743: Why Your Heart Risk Changes in Menopause (And What You Can Do About It) with Dr. Jayne Morgan

In this groundbreaking conversation, Professor of Genetics and longevity scientist, Dr. David Sinclair, A.O., Ph.D., joins Sarah Grynberg to unpack the future of human aging, the science oflongevity, and how we live today impacts how we age tomorrow.From reversing blindness in mice to exploring treatments that could one day delay menopause and extend healthy human life, this episode will completely change the way you think about your body, your health, and your future.But beyond the science, this is also a deeply human conversation about purpose, suffering, love, family, and what it truly means to live a great life.In this episode, you will learn:Why aging may actually be reversibleThe daily habits accelerating aging in your body right nowHow stress, loneliness, and cortisol could impact longevityThe real science behind supplements like NMN, resveratrol, and NAD boostersWhy exercise, sleep, and relationships matter more than you thinkWhat Dr. Sinclair believes is coming in the next 10 years of medicineHow scientists are working to reverse female infertility and delay menopauseThe surprising reason your “biological age” may be younger or older than your real ageWhy suffering through disease and decline should not be considered “normal aging”The philosophy and mindset Dr. Sinclair lives by every dayThis episode is a powerful reminder that longevity is not just about living longer… it's about living better.To find out more about Dr Sinclair's work:Website: lifespan.com and friendsofsinclairlab.orgBook: Lifespan: Why We Age—and Why We Don't Have ToPodcast: Lifespan with Dr. David Sinclair on Spotify, Apple, YouTubePurchase Sarah's book: Living A Life Of Greatness here.To purchase Living A Life of Greatness outside Australia here or here.Watch A Life of Greatness Episodes On Youtube here.Sign up for Sarah's newsletter (Greatness Guide) here.Purchase Sarah's Meditations here.Instagram: @sarahgrynberg Website: https://sarahgrynberg.com/Facebook: facebook.com/sarahgrynbergTwitter: twitter.com/sarahgrynberg Hosted on Acast. See acast.com/privacy for more information.

Many women worry that starting HRT will make them put on weight – but is this fear actually backed by science? Liz explores the link between hormones, metabolism and midlife weight changes, and explains why fluctuating oestrogen, poor sleep and stress may be more to blame than HRT itself.Plus: supportive supplements for coeliac disease, ways to boost a low libido, skincare non-negotiables, tapping into vibrational energy and a deep dive into NAD+. In this episode:· Will HRT make me put on weight?· Which skincare ticks the non-negotiable boxes?· How to boost a flagging libido· What are NAD+ and berberine and should I take them?· Supportive supplements (and tests) for coeliac disease· Unlocking the wellness and longevity benefits of vibrational energyLinks mentioned in the episode:· Ceramides· Vitamin C serum· Peptides· Retinol· What are NAD+ and NMN?· Podcast with Dr Mo Enyat on zonulin testing for autoimmune conditions· Zinc· B12· Calcium· Vitamin D· Omega-3· Collagen· Magnesium Get in touch with a question for Liz:· Email: podcast@lizearlewellbeing.com· WhatsApp: 07518 471 846More from Liz:· Order Liz's new book – How to Age· A Better Second Half· Follow Liz on Instagram· Follow Liz Earle Wellbeing on InstagramHost: Liz EarleProducer: Lynnike Swerts (Fresh Air Production)Social Media Manager: Naomi van GeelenContent Writer: Lucy ParleyHead of Brand: Ellie SmithSome links may be affiliate links, which help support the show at no extra cost to you. Read our Affiliate Policy for more information. Hosted on Acast. See acast.com/privacy for more information.

La creatina es el suplemento más vendido del mundo.Y hay una conversación que nadie en la industria quiere tener sobre ella y el cáncer.En este episodio Carlos Muñoz habla sin filtros con un experto en medicina de frontera sobre lo que realmente alarga la vida — y lo que te están vendiendo que no funciona.━━━━━━━━━━━━━━━━━━━━━━━━━━━━━

A case study where a second opinion is necessaryWhat are your thoughts on the recent news implicating niacin in cardiovascular disease? 

If you're constantly exhausted and your hair seems thinner than normal, it might not just be your hormones. Liz talks about low iron levels in midlife, how to spot the symptoms and what to do if you're struggling.Plus: where to start with longevity supplements, ways to manage high cholesterol, juggling HRT on a busy schedule and advice for troubled teenage skin.In this episode:· 3 ways to boost your iron levels· Where to start with supplements· Managing high cholesterol without statins· Treatment for teenage skin concerns· Travel-friendly HRT treatmentLinks mentioned in the episode:· NMN and other NAD-boosting supplements· Urolithin A· Liz's go-to supplement routine· Podcast with Dr Mo Enayat on leaky gut, cholesterol and peptides· MV Skintherapy multiBALM· HRT explained articleGet in touch with a question for Liz:· Email: podcast@lizearlewellbeing.com· WhatsApp: 07518 471 846 More from Liz:· Order Liz's new book – How to Age· A Better Second Half· Follow Liz on Instagram· Follow Liz Earle Wellbeing on Instagram Host: Liz EarleProducer: Lynnike Swerts (Fresh Air Production)Social Media Manager: Naomi van GeelenContent Writer: Lucy ParleyHead of Brand: Ellie Smith Some links may be affiliate links, which help support the show at no extra cost to you. Read our Affiliate Policy for more information. Hosted on Acast. See acast.com/privacy for more information.

Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down — and how to stop it. Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down — and how to stop it.

Getting support for your perimenopause and menopause symptoms can be a struggle, and many clinicians are still inadequately trained in hormone health. Liz talks about the barriers women still face and ways to feel confident requesting HRT.Plus: easy ways to stay hydrated, the benefits of NMN supplements, hair dye for a sensitive scalp and easy ways to reduce our risk of falls as we get older.In this episode:· What to do when you feel shut down by your GP· How to dye your hair if your scalp is sensitive· Protecting yourself from falls as you get older· Tips for staying hydrated when you don't drink water· What are NMN supplements and who should take them? Links mentioned in the episode:· NHS shared decision-making· NICE menopause guidance· Josh Wood PPD-free hair colour· Article on the benefits of NMN· NMN and other NAD-boosting supplements Get in touch with a question for Liz:· Email: podcast@lizearlewellbeing.com· WhatsApp: 07518 471 846 More from Liz:· Order Liz's new book – How to Age· A Better Second Half· Follow Liz on Instagram· Follow Liz Earle Wellbeing on Instagram Some links may be affiliate links, which help support the show at no extra cost to you. Read our Affiliate Policy for more information. Hosted on Acast. See acast.com/privacy for more information.

Full Show Notes: https://bengreenfieldlife.com/nadplus In this fascinating episode, Dr. Nichola Conlon, molecular biologist and founder of Nuchido, breaks down what NAD actually is, what it does inside your cells, and why most popular strategies for boosting it, including NAD IVs, patches, and high-dose NR or NMN, may be fundamentally flawed based on molecular biology. You’ll discover why NAD declines by half every 20 years, why the NAMPT enzyme and not a shortage of raw material is the real bottleneck, and why flooding the body with precursors without fixing the salvage pathway can actually strain your methylation pathways rather than raise NAD. You’ll also explore how inflammation through the cluster of differentiation 38 (CD38) enzyme silently drains NAD faster than almost anything else, what a gold standard double-blind placebo-controlled crossover clinical trial on Nuchido TIME+ actually showed, and why NAD sits at the intersection of energy production, cellular repair, sleep, skin health, and biological aging. Dr. Nichola Conlon (BSc, MRes, PhD) specializes in cellular aging. After a career in drug development, Dr. Nichola founded Nuchido, driven by her belief that cutting-edge science should not lie hidden. At Nuchido, Dr. Nichola’s work focuses on delivering disruptive innovation in the field of anti-aging, rejuvenation, and healthspan. It has led to the development of Nuchido TIME+, a dietary supplement clinically proven to boost NAD+ and reverse biological age. Unlike standard precursors such as NMN or NR, Nuchido TIME+ uses a systems-based approach to target the root causes of NAD+ decline.

If you don't have energy, you don't have art. Let's talk about how to stay sharp, creative, and energized as you age. Here's something most artists don't think about until it's already a problem … Your body is part of your creative process. If you're exhausted, foggy, and running on empty, it becomes harder to show up, harder to focus, and harder to create consistently. In this episode, I sit down with Alan Graves to talk about longevity, energy, and how to support your body and brain so you can keep making your best work for years to come. We dive into the science behind energy decline, what's happening in your body as you age, and what you can actually do to feel better and think more clearly. Because this isn't about vanity. It's about vitality. Make sure to subscribe to this podcast so you don't miss a thing! And don't forget to come hang with me on Instagram @jodie_king_. Interested in being a guest on a future episode of Honest Art®? Email me at amy@jodieking.com! Resources mentioned: Ready to push your work to Fine Art status? Join me at one of my Honest Art® Workshops - https://jodieking.com/workshop  Ready to make your best art ever, alongside an incredible community of artists? Join us inside the Honest Art Society today! - https://www.jodiekingart.com/has  Don't Miss the Latest from DoNotAge: Get the Cycle Pouches Routine and don't forget to use code SMOKESHOW: https://routine.donotage.org/donotage?ref=smokeshow Visit DoNotAge.Org and use code SMOKESHOW - http://DoNotAge.Org  Jodie loves NMN for NAD Levels (don't forget to use code SMOKESHOW!) - https://donotage.org/pure-nmn  Alan mentions CoQ10 for supporting mitochondrial function … aka making energy (don't forget to use code SMOKESHOW!) - https://donotage.org/pure-coq10  Hyaluronic Acid isn't just for skincare! (don't forget to use code SMOKESHOW!) -https://donotage.org/pure-hyaluronic-acid  Spermidine helps your body's "recycling system" (don't forget to use code SMOKESHOW!) - https://donotage.org/pure-spermidine  Creatine has helped support Jodie's memory (don't forget to use code SMOKESHOW!) - https://donotage.org/creatine  You'll Also Love Episode 104: Secrets for Maintaining Vitality with Alan Graves of Do Not Age - https://jodieking.com/episode-104-secrets-for-maintaining-vitality-with-alan-graves-of-donotage/  Follow DoNotAge on Instagram - https://www.instagram.com/do.not.age/  Follow Alan Graves on Instagram - https://www.instagram.com/alanjackgraves/  Have a question for Jodie? Ask it here: https://forms.gle/hxrVu4oL4PVCKwZm6  How are you liking the Honest Art® Podcast? Leave us a review on your favorite podcast platform and let us know!     Watch this full episode on my YouTube channel: https://www.youtube.com/playlist?list=PLMquJfuMsSg0fr46BRdia1cWd-81GThzF For a full list of show notes and links, check out my blog: www.jodieking.com/podcast  

Welcome to the latest episode of LIFTS, your bite-sized dose of the Latest Industry Fitness Trends and Stories. In this episode, hosts Matthew Januszek and Mohammed Iqbal explore one of the most talked-about topics in modern wellness: NAD and the rapid rise of longevity therapies. Joined by Rachele Pojednic, Chief Science Officer at Restore Hyper Wellness, the conversation breaks down what NAD actually is, how it functions within the body, and why it has become such a focal point in energy, recovery, and healthy aging. As wellness clinics, IV therapies, and performance treatments continue to grow in popularity, NAD has emerged as a central molecule in the conversation around optimisation and longevity. However, as interest increases, so too does the gap between consumer awareness, scientific understanding, and real-world application. The discussion explores the biology behind NAD, including its role in cellular energy production, metabolism, and DNA repair, while also examining the different forms of NAD and its precursors, such as NR and NMN. Matthew and Mo share their own experiences with NAD therapies, opening up a broader discussion around delivery methods, perceived benefits, and the difference between anecdotal outcomes and evidence-based practice. As the conversation develops, Rachel highlights the importance of understanding not just the therapy, but the underlying molecule, and why factors such as dosage, delivery method, and cellular transport play a critical role in determining effectiveness. The episode also addresses the wider challenges within the wellness industry, including the speed at which new therapies are being adopted, the influence of biohacking culture, and the growing need for scientific validation and safety data. For operators, this episode provides valuable insight into both the opportunities and responsibilities associated with integrating longevity and wellness services into fitness environments. In this episode, we cover: What NAD is and how it works in the body Why NAD levels decline with age The rise of NAD and wellness clinics The difference between NAD, NR, and NMN Why delivery method and molecule selection matter The gap between wellness hype and scientific evidence Safety considerations, dosage challenges, and unknowns

Send us Fan MailWrinkles, sagging, and pigment are easy targets because we can see them, measure them, and sell treatments for them. But I keep coming back to a more uncomfortable question: are we actually treating aging, or are we only managing the appearance of aging? In this conversation, I sit down with Dr. Suzan Obagi, a leader in cosmetic dermatology and cosmetic surgery and Associate Professor in Dermatology and Plastic Surgery from the University of Pittsburgh Medical Center and former President of the American Academy of Cosmetic Surgery, to follow the smoke back to the fire and talk about what really drives skin aging and recovery.We break down intrinsic aging versus extrinsic aging and why epigenetics, inflammation, and oxidative stress matter as much as lasers and injectables. Dr. Obagi explains what collagen, elastin, and glycosaminoglycans do, why their production peaks early, and why menopause can accelerate collagen decline. We also get honest about hormone replacement therapy: how estrogen affects skin, mood, joints, vessels, brain health, and wound healing, where risks truly live, and why many women are still mismanaged with symptom-only fixes. If you care about healthspan, longevity, menopause skin changes, and better surgical outcomes, this part will shift your perspective.Then we turn practical. You'll hear the simplest high-yield skincare routine we both rely on: cleansing, well-formulated antioxidants morning and night, moisturizers that support barrier function, mineral sunscreen, and retinoids with realistic timelines for results. We also unpack why some medspa “annual” treatment advice keeps people on a treadmill, and we look ahead at where anti-aging medicine may go next, from rapamycin analogs to NMN to the promise and complexity of Yamanaka factors.If this made you rethink your approach to anti-aging skin care, hormone health, or aesthetic medicine, subscribe, share the episode with a friend, and leave a review so more people can find it.Dr. Suzan Obagi links:Instagram: @suzanobagimdWebsite:http://dermatology.pitt.edu/people/suzan-obagi-mdTweet me @realdrhamrahIG @drhamrah

We're excited to share another episode in our podcast series featuring heavily vetted companies. Today, I'm delighted to connect with Baran Dilaver. Baran is an entrepreneur, creator, and accomplished executive, and also the co-founder of Wonderfeel Biosciences, a longevity-focused bioscience company that pioneers cellular health innovations through its patented NAD products. (You will likely remember the dynamic interview I did last year with Dr. Andrew Salzman, the MD and Chief Medical Officer of Wonderfeel.) In today's conversation, Baran and I explore the science of cellular energy and its wide-ranging benefits. We cover the physiology of NAD and other nutraceuticals, the key markers of inflammation, and the precursors in Wonderfeel's formulas that enhance absorption and assimilation. We discuss how NAD and creatine monohydrate each fuel cellular energy, their powerful synergistic effects, and the NAD-creatine combination as a powerful midlife stack. We also get into brain fog, mood, and stress resilience, along with the FDA's clarification on NMN and other nutraceuticals, and why NAD injections and IV NAD may fall short compared to oral precursors like NMN and NR. I also share my experience trying Wonderfeel's newest product, Choco Creatine. You won't miss this in-depth conversation with Baran Dilaver of Wonderfeel, as he shares his expert perspective on NAD and creatine monohydrate supplementation. IN THIS EPISODE, YOU WILL LEARN: What recent research from Harvard and MIT has shown about the benefits of increasing NAD levels Why NAD is so essential Baran describes how reduced NAD affects each organ differently How inflammation becomes a key signal of declining NAD levels Why precursors like NMN and NR are necessary for increasing intracellular NAD levels What led Baran to explore how to make NAD compounds more accessible to consumers? How NAD and creatine work synergistically to improve brain and gut functioning How compromised gut integrity drains our energy and forces the body into “overdrive.” Baran outlines the complexities of product development Why ingredients like resveratrol and hydroxytyrosol are included in the Wonderfuel NAD formula Bio: Baran Dilaver Baran is an entrepreneur, creator, and an accomplished executive. He is the Co-founder of Wonderfeel Biosciences, a longevity-focused biosciences company that pioneers cellular health innovations through its patented NAD products. Previously, he led numerous start-ups successfully, served as CEO and COO at public and private companies, where he collaborated with top scientists, visionaries, and medical experts, and developed award-winning products. He is a frequent speaker at conferences like Tech Open Air, Wonderland, and Brandweek. At UC Berkeley, he studied economics and earned athletic and academic scholarships. He gets a special thrill from enhancing people's lives with the products he helps innovate. Baran has been leading the NAD and longevity related initiatives at Wonderfeel Biosciences as its Co-founder and CEO, co-writing a number of patent applications, in vitro and in vivo studies, collecting consumer feedback and helping the Wonderfeel medical team publish peer reviewed papers and by participating high profile interviews and podcasts with the likes of Dr. Mark Hyman and Dave Asprey and speaking at conferences like the Biohacker Summit. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website. Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow. Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Baran Dilaver On the Wonderfeel website Previous Episode Mentioned BONUS: Why NAD Matters for Women's Health & Hormones

Dr. Rhonda Patrick, PhD, is a biomedical scientist and public science educator. She shares the exercise, nutrition, supplementation and lifestyle practices linked to better health and lower disease risk including specific cardio and resistance training routines, when and why to do intermittent fasting, ways to lower visceral fat, omega-3 sourcing, creatine for brain and muscle and peptides such as BPC-157. It's broad and thorough coverage of how to build a total health program tailored to your goals and individual biology. Read the show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Our Place: https://fromourplace.com/huberman Lingo: https://hellolingo.com/huberman LMNT: https://drinklmnt.com/huberman Function: https://functionhealth.com/huberman Mateina: https://drinkmateina.com/huberman Timestamps 00:00:00 Rhonda Patrick (00:02:40) Competition, Jumping Rope, Rope Flow (00:06:49) Rhonda's Exercise Routine, Cardiovascular & Resistance Training (00:12:30) Cognitive & Physical Benefits of Exercise, Serotonin & Impulse Control (00:14:40) Sponsors: Our Place & Lingo (00:17:03) Phones While Training? (00:18:45) Rhonda's Strength Training, Low-Reps, Modifications, Mental Resilience (00:27:00) Daily Protein Intake, Intermittent Fasting, Processed Carbohydrates (00:33:32) Lipopolysaccharide (LPS); Gut Permeability, Gluten; Cardiovascular Health (00:42:58) Sponsor: AG1 (00:44:21) Tight Junctions, Gut, Neuroinflammation (00:47:26) L-glutamine, Immune System, Cancer Risk (00:54:55) N-acetylcysteine (NAC), Vitamin E; Antioxidant Balance, Reductive Stress (01:00:08) Starch, Tool: Bedtime Fast & Cardiovascular Health (01:03:36) Cortisol, Intermittent Fasting Benefits (01:08:09) Cortisol, Train Fasted?; Hormones, Visceral Fat (01:13:35) Visceral Fat, Perimenopause/Menopause, Insulin Resistance in Brain & Body (01:21:13) Sponsor: LMNT (01:22:33) Cortisol & Sleep (01:25:42) Intermittent Fasting, Metabolic Switch, Ketones, Muscle Loss? (01:36:47) Tools: Logic-Based Habits; Daily Metabolic Switch; Exercise, Autophagy (01:45:06) Exercise After Poor Sleep?; Training Breaks (01:52:47) Tool: "Exercise Snacks"; Sedentary Lifestyle & Cardiorespiratory Fitness (02:03:31) Sponsor: Function (02:05:16) Creatine, Dose, Resistance Training, Cognitive Function (02:17:43) Biology; Creatine; Supplement Safety (02:25:18) Omega-3s, Inflammation, Cancer Risk, Vitamin D; Trans Fat (02:36:52) Magnesium Threonate vs Bisglycinate, Sleep, Cognitive Benefit; Vitamin D (02:45:46) Supplement Types, Multivitamin, Coenzyme Q10, Urolithin A, Sulforaphane (02:55:10) Microplastics (02:57:26) Sponsor: Mateina (02:58:28) BPC-157, NMN, NR, Tool: Evaluating Supplements, Safety, Sources (03:06:28) L-Carnitine, Alpha-GPC, Nicotine, GABA & Ketogenic Diet (03:15:20) Nattokinase; Microplastics, Water Bottles; Seed Oils (03:22:21) Sauna, Creatine for Kids?, Bananas, Tool: Evaluating Studies (03:28:37) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Most people think feeling tired, foggy, and “off” is just what happens with age.But what if the real issue is that your cells are running on less fuel than they used to?In this episode of the Kwik Brain podcast, I sit down with Dr. Andrew Salzman, Harvard-trained physician, inventor, and biomedical entrepreneur, to unpack what's happening at the cellular level when energy drops and your brain stops feeling sharp.We break down NAD, a molecule involved in hundreds of critical reactions in the body, why it declines as you age, and how inflammation can accelerate that decline. We also talk about NMN, and why your brain is often the first place you feel the effects when cellular energy dips.In this episode, you'll learn: ☑️ What NAD does for energy, cognition, and resilience ☑️ Why NAD drops so significantly by midlife ☑️ How NMN works as a precursor to support NAD production ☑️ The “bathtub” model: why boosting NAD is not just about adding more, but also slowing the drain ☑️ How inflammation can drive NAD depletion through CD38 ☑️ Why better cellular energy can translate into clearer thinking, better memory, and sharper focusIf you've been feeling like your brain isn't firing the way it used to, your energy is unpredictable, or your focus is slipping, this episode will help you understand what's happening underneath the surface and what you can do to support your brain at the level where performance actually starts: your cells.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your gray hair, thinning lashes, brain fog, and that low energy feeling after 30 might all trace back to one thing: falling NAD and stressed mitochondria. This episode breaks down what actually happens inside your cells as NAD declines, and what you can do about it using specific compounds from mushrooms, olive oil, and even chocolate. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Subscribe and save $15 on Wonderfeel by going to: https://getwonderfeel.com/product/wonderfeel-youngr-nmn/?utm_source=Dave&utm_medium=podcast&utm_campaign=episode2Host Dave Asprey sits down with Baran Dilaver, CEO and co-founder of Wonderfeel Biosciences, to unpack the real science behind NAD, mitochondrial energy, and long-term longevity. Baran is an entrepreneur and inventor who previously led multiple start-ups as CEO and COO, collaborated with leading scientists and medical experts, and developed award-winning products. A UC Berkeley economics graduate and former scholarship athlete, he now focuses on translating cutting-edge bioscience into practical tools that enhance people's lives. They break down how NAD powers mitochondria, why your body strategically allocates cellular energy away from peak cognitive performance as you age, and how stress accelerates that decline. You'll hear the differences between niacinamide, NR, and NMN, the FDA confusion around NMN, and why raising NAD is about cellular repair, resilience, and metabolic function, not just “more energy.” The conversation goes deep on hydroxytyrosol, the powerful olive oil polyphenol that acts as a CD38 inhibitor, and ergothioneine, a mushroom-derived antioxidant with its own receptor in the human body that can accumulate in damaged tissues. Baran shares the origin story that pushed him to research ergothioneine, along with anecdotal observations from long-term users reporting improvements in sleep, focus, energy, thicker hair, reduced gray hair, and even eyelash regrowth. You'll also hear Dave's practical take on ketosis, fasting, supplements, and metabolism, why he prefers NAD precursors over IV NAD for most people, how methyl donors affect NAD IV tolerance, and why Wonderfeelbuilt a creatine chocolate bar sweetened with allulose to stay keto-friendly and diabetic-friendly. This is biohacking grounded in mechanism, from mitochondria and neuroplasticity to anti-aging strategy and smarter supplementation. You'll Learn: • What NAD does in the body and why oral NAD itself is not effective • How niacinamide, NR, and NMN compare as NAD precursors • Why mitochondria control energy allocation, cognition, and resilience • How hydroxytyrosol may support NAD longevity through CD38 inhibition • What ergothioneine is, why it comes from mushrooms, and why the body has a receptor for it • What long-term users commonly report: better sleep, clearer thinking, stronger energy, and cosmetic shifts • Why Dave prefers supplements over NAD IVs in most cases • How allulose differs from other sweeteners and why it matters for metabolism • Why creatine supports brain energy and how heat changes absorption strategy Thank you to our sponsors! • MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order • Branch Basics | Get 15% off at https://branchbasics.com/DAVE15 with code DAVE15 • Timeline | Go to timeline.com/Dave for 20% off• OneSkin | Try OneSkin at https://www.oneskin.co/DAVE and use code DAVE for 15% off Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: NAD supplementation, NMN benefits, NR vs NMN, nicotinamide mononucleotide, mitochondrial function, CD38 inhibition, hydroxytyrosol olive oil, ergothioneine mushrooms, mushroom antioxidant benefits, Alzheimer's prevention strategies, brain fog after 30, mitochondrial energy production, anti aging supplements, longevity compounds, fertility mitochondrial health, NAD IV vs oral NMN, creatine for brain health, allulose sweetener benefits, keto friendly chocolate, GLP 1 natural support, biohacking longevity, neuroplasticity support, metabolism optimization, fasting and NAD levels, ketosis and mitochondria, supplement regulation FDA, functional medicine longevity, Dave Asprey biohacking, Wonderfeel NMN Resources: • Wonderfeel Website: https://getwonderfeel.com/product/wonderfeel-youngr-nmn/?utm_source=Dave&utm_medium=podcast&utm_campaign=episode2• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 - Introduction 01:13 - What Is Wonderfeel 05:31 - NAD and NMN Explained 09:41 - FDA Status of NMN 13:50 - Supplements vs Pharmaceuticals 16:48 - How NAD Powers Mitochondria 25:46 - NAD Benefits and Effects 30:57 - Hydroxytyrosol 35:03 - Ergothioneine 41:55 - Alzheimer's and Brain Health 44:10 - Vitamin D and K2 46:15 - Sustainable Packaging 49:26 - Creatine Bars 51:43 - Allulose Deep Dive 59:28 - Inflammation Research 01:02:15 - Supplement Regulation See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.