Podcasts about nmn

NAD+ has become the longevity industry's favorite molecule, sold as as a supplement and as a four-hour IV that promises sharper thinking, more energy, and slower aging. But a new 2026 paper complicates the very story it was built on. In this episode, Jeff breaks down what NAD+ actually is, what the human trials really show, and why the gap between a $40 oral supplement and a $1,200 IV drip matters more than the marketing admits. You'll learn about: What NAD+ does in the body and why it got tied to aging The new research questioning whether NAD+ truly declines with age Oral NR and NMN versus IV infusions, and what the evidence supports The risks rarely mentioned, including the cancer question Why the saline, B vitamins, and forced rest may explain how good people feel This episode is for anyone weighing NAD+, longevity supplements, or an IV drip, and who wants to tell real science from wellness hype first. This episode was made possible by: LMNT: Get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at drinklmnt.com/commune. Stemregen: Get 20% off your first order at stemregen.co/commune with the code COMMUNEPOD Vivobarefoot: Try Vivobarefoot risk-free with a 100-day return guarantee, and get 15% off your order at ⁠vivobarefoot.com/commune⁠. Stripes: Visit stripesbeauty.com and use the code COMMUNE20 for 20% off our entire product line. Sunlighten: Visit sunlighten.com/commune Up to 2,100 off saunas and $50 off Red Light Products with code “COMMUNE”

How CD38, PARP, and Leaky Gut Are Destroying Your NAD Levels | Dr. Andrew Salzman Your NAD is being drained by two hidden enzymes, your gut may be the starting point of every aging process in your body, and creatine does something to your mitochondria that has nothing to do with muscle. This episode rewrites what you thought you knew about longevity, anti-aging biology, and how your body actually produces and delivers energy at the cellular level. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Explore all of Wonderfeel's products at: getwonderfeel.com/dave They are gifting a complimentary 7-day Youngr™ supply (mini pouch) with every order across any of their products. The code will be DAVE, and the campaign will be active through June 6th. Host Dave Asprey sits down with Dr. Andrew Salzman, a physician, inventor, and biomedical entrepreneur with more than 30 years of experience in drug discovery and development. An alumnus of Harvard Medical School, Yale University, and Columbia University, Dr. Salzman has authored more than 170 scientific publications and holds 50 patents. He invented the original clinical-stage PARP-1 inhibitor, leading to the world's first clinical treatment for raising NAD levels and fighting cancers caused by the BRCA1 and BRCA2 genes. Genentech licensed his breakthrough technology for $600 million. His research into gastrointestinal microbiota, autoimmune disease, oxidative stress, and mitochondrial ATP production now forms the foundation of how millions of patients get treated worldwide. Dr. Salzman names the two biggest NAD drains in your body, CD38 and PARP, and explains why taking NMN or NR alone is like filling a bathtub with the drain wide open. He breaks down the formulation science behind pairing NAD precursors with CD38 blockers like hydroxytyrosol alongside PARP-reducing antioxidants like ergothioneine, and delivers a paradigm-shifting explanation of creatine as an energy distribution network inside your cells. Rather than a simple muscle supplement, creatine acts as a high-speed ATP shuttle that carries energy from your mitochondria to the precise location and moment your brain, gut, and heart need it most. You'll Learn: Why NAD declines with age and which two enzymes are primarily responsible for draining it How CD38 rises with inflammation rather than NAD levels, and what that means for your supplement strategy Why creatine is one of the most underrated anti-aging and brain optimization supplements available How creatine functions as a spatial and temporal energy delivery network for your brain, gut, and heart Why the gut may be the origin point of the entire aging process and how that cascade unfolds decade by decade How leaky gut drives systemic inflammation, crashes NAD, and accelerates biological aging throughout the body What controls tight junction integrity and how ATP, butyrate, creatine, and fasting all play a role Why most creatine supplements fail to absorb properly and what to look for in a high-quality source How to rebuild your microbiome in three to four weeks through diet alone, without antibiotics Why walking immediately after a meal may be doing more harm than good to your gut lining Thank you to our sponsors! - Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. - KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off - Pique | Go to Piquelife.com/dave for 20% off. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. Andrew Salzman, NAD depletion, CD38 inhibition, PARP inhibition, NMN supplements, creatine ATP shuttle, leaky gut aging, tight junction integrity, inflammaging, lipopolysaccharide gut, flagellin toxin, butyrate gut healing, ergothioneine, hydroxytyrosol, peroxynitrite, superoxide mitochondria, creatine energy distribution, gut origin of aging, NAD bathtub analogy, BRCA PARP inhibitor, Wonderfeel, creatine monohydrate, intestinal permeability, microbiome butyrate, selective digestive decontamination, TMAO nitric oxide Resources: • Explore all of Wonderfeel's products at: getwonderfeel.com/dave • Order Youngr™: getwonderfeel.com/dave• Order ChocoCreatin™: getwonderfeel.com/dave• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 01:12 – Introduction & BRCA Background 02:19 – DNA Damage & PARP 04:38 – Free Radicals & Oxidative Stress 11:37 – NAD & Antioxidant Defense 12:34 – CD38 & NAD Depletion 23:31 – The Gut-Aging Hypothesis 30:05 – ATP, Creatine & Energy Distribution 36:41 – Creatine as Energy Shuttle 51:09 – Microbiome & Gut Repair 59:21 – TMAO & Nitric Oxide Interference 1:03:52 – Flagellin & Gut Inflammation Research 1:09:45 – FDA & Pharmaceutical Incentives 1:16:05 – Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

“What if the exhaustion, brain fog, low libido, and metabolic changes women experience in midlife are actually rooted in a deeper cellular energy crisis?” In this episode, Dr. Mariza sits down with Dr. Andrew Salzman — physician, inventor, biochemical engineer, and Chief Scientific Officer of Wonderfeel — to unpack the powerful connection between NAD, mitochondrial health, inflammation, ovarian aging, gut integrity, nitric oxide, and the dramatic energy shifts women experience during perimenopause and menopause. Dr. Salzman explains why menopause represents a major biological inflection point for women and how declining NAD levels may be contributing to fatigue, brain fog, poor recovery, metabolic dysfunction, sleep issues, reduced stress resilience, cardiovascular changes, and shifts in sexual health. Together, they explore the evolutionary role of menopause, why ovarian senescence accelerates aging pathways, how inflammation and the enzyme CD38 rapidly deplete NAD stores, and why the gut microbiome may be one of the biggest drivers of inflammation and energy decline in modern women. They also dive into nitric oxide production, cardiovascular health, the brain's dependence on NAD for sleep and cognitive function, and why ingredients like NMN and creatine are gaining attention for supporting healthy aging and resilience in midlife. If you've ever looked in the mirror and thought, “I don't feel like myself anymore,” this conversation will help connect the dots between your symptoms, your mitochondria, and your long-term vitality. ANDREW SALZMAN Dr. Andrew Salzman is a physician, inventor, biochemical engineer, and the Chief Scientific Officer of Wonderfeel. With more than 30 years of experience in drug discovery and development, over 170 scientific publications, and more than 50 patents, Dr. Salzman has spent decades studying aging biology, inflammation, cellular resilience, nitric oxide signaling, and mitochondrial health IN THIS EPISODE Why menopause is a major biological inflection point for women How declining NAD levels impact energy, metabolism, sleep, and brain function Why CD38 accelerates inflammation and NAD depletion during aging The surprising connection between gut health, inflammation, and menopause symptoms How estrogen decline contributes to leaky gut and systemic inflammation Why nitric oxide is essential for circulation, libido, cardiovascular health, and cognition The role of NAD in circadian rhythm, sleep quality, and stress resilience Why NMN and creatine are gaining attention for healthy aging and vitality QUOTES“Menopause will happen, but the question is: how do we maintain vibrancy and resilience through it?” “NAD is the common currency that drives energy throughout the body.” “The gut is the foundational driver of inflammation as we age.” “Without NADPH, you don't have nitric oxide production.” RESOURCES MENTIONED Subscribe and Save $15 on Wonderfeel Youngr™ NMN: https://tidd.ly/4rPnckS Use code ENERGIZED and get 30% off on your first BATCH order https://hellobatch.com/ENERGIZED Order my newest book: The Perimenopause Revolution https://peri-revolution.com/ Wonderfeel Website Wonderfeel Instagram Wonderfeel YouTube RELATED EPISODES  741: Estrogen, Gut Health, Mitochondria, and Cardiovascular Health: What Changes In Perimenopause with Dr. Siobhan Mitchel 691: The Fertility Crisis No One Talks About: Why Your Health Today Impacts Future Generations with Dr. Ann Shippy 717: “I Don't Feel Like Myself Anymore”: The Mental & Emotional Reality of Perimenopause 743: Why Your Heart Risk Changes in Menopause (And What You Can Do About It) with Dr. Jayne Morgan

In this groundbreaking conversation, Professor of Genetics and longevity scientist, Dr. David Sinclair, A.O., Ph.D., joins Sarah Grynberg to unpack the future of human aging, the science oflongevity, and how we live today impacts how we age tomorrow.From reversing blindness in mice to exploring treatments that could one day delay menopause and extend healthy human life, this episode will completely change the way you think about your body, your health, and your future.But beyond the science, this is also a deeply human conversation about purpose, suffering, love, family, and what it truly means to live a great life.In this episode, you will learn:Why aging may actually be reversibleThe daily habits accelerating aging in your body right nowHow stress, loneliness, and cortisol could impact longevityThe real science behind supplements like NMN, resveratrol, and NAD boostersWhy exercise, sleep, and relationships matter more than you thinkWhat Dr. Sinclair believes is coming in the next 10 years of medicineHow scientists are working to reverse female infertility and delay menopauseThe surprising reason your “biological age” may be younger or older than your real ageWhy suffering through disease and decline should not be considered “normal aging”The philosophy and mindset Dr. Sinclair lives by every dayThis episode is a powerful reminder that longevity is not just about living longer… it's about living better.To find out more about Dr Sinclair's work:Website: lifespan.com and friendsofsinclairlab.orgBook: Lifespan: Why We Age—and Why We Don't Have ToPodcast: Lifespan with Dr. David Sinclair on Spotify, Apple, YouTubePurchase Sarah's book: Living A Life Of Greatness here.To purchase Living A Life of Greatness outside Australia here or here.Watch A Life of Greatness Episodes On Youtube here.Sign up for Sarah's newsletter (Greatness Guide) here.Purchase Sarah's Meditations here.Instagram: @sarahgrynberg Website: https://sarahgrynberg.com/Facebook: facebook.com/sarahgrynbergTwitter: twitter.com/sarahgrynberg Hosted on Acast. See acast.com/privacy for more information.

La creatina es el suplemento más vendido del mundo.Y hay una conversación que nadie en la industria quiere tener sobre ella y el cáncer.En este episodio Carlos Muñoz habla sin filtros con un experto en medicina de frontera sobre lo que realmente alarga la vida — y lo que te están vendiendo que no funciona.━━━━━━━━━━━━━━━━━━━━━━━━━━━━━

Ihr habt gefragt, Max und Mario antworten: In dieser Ask-me-anything-Folge des Beyond Lifespan Podcasts geht es um NAD-Booster wie NMN und NR, mögliche Langzeitrisiken von Longevity-Supplements, Fruchtbarkeit, Antioxidantien, Resveratrol, Omega-3, WHOOP-Daten, Kollagen für Sehnen und die Frage, ob Longevity auch ohne ständigen Verzicht funktioniert.

A case study where a second opinion is necessaryWhat are your thoughts on the recent news implicating niacin in cardiovascular disease? 

If you're constantly exhausted and your hair seems thinner than normal, it might not just be your hormones. Liz talks about low iron levels in midlife, how to spot the symptoms and what to do if you're struggling.Plus: where to start with longevity supplements, ways to manage high cholesterol, juggling HRT on a busy schedule and advice for troubled teenage skin.In this episode:· 3 ways to boost your iron levels· Where to start with supplements· Managing high cholesterol without statins· Treatment for teenage skin concerns· Travel-friendly HRT treatmentLinks mentioned in the episode:· NMN and other NAD-boosting supplements· Urolithin A· Liz's go-to supplement routine· Podcast with Dr Mo Enayat on leaky gut, cholesterol and peptides· MV Skintherapy multiBALM· HRT explained articleGet in touch with a question for Liz:· Email: podcast@lizearlewellbeing.com· WhatsApp: 07518 471 846 More from Liz:· Order Liz's new book – How to Age· A Better Second Half· Follow Liz on Instagram· Follow Liz Earle Wellbeing on Instagram Host: Liz EarleProducer: Lynnike Swerts (Fresh Air Production)Social Media Manager: Naomi van GeelenContent Writer: Lucy ParleyHead of Brand: Ellie Smith Some links may be affiliate links, which help support the show at no extra cost to you. Read our Affiliate Policy for more information. Hosted on Acast. See acast.com/privacy for more information.

Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down — and how to stop it. Your cells start failing at 35. Dr Sandra Kaufmann reveals the 7 systems breaking down — and how to stop it.

Getting support for your perimenopause and menopause symptoms can be a struggle, and many clinicians are still inadequately trained in hormone health. Liz talks about the barriers women still face and ways to feel confident requesting HRT.Plus: easy ways to stay hydrated, the benefits of NMN supplements, hair dye for a sensitive scalp and easy ways to reduce our risk of falls as we get older.In this episode:· What to do when you feel shut down by your GP· How to dye your hair if your scalp is sensitive· Protecting yourself from falls as you get older· Tips for staying hydrated when you don't drink water· What are NMN supplements and who should take them? Links mentioned in the episode:· NHS shared decision-making· NICE menopause guidance· Josh Wood PPD-free hair colour· Article on the benefits of NMN· NMN and other NAD-boosting supplements Get in touch with a question for Liz:· Email: podcast@lizearlewellbeing.com· WhatsApp: 07518 471 846 More from Liz:· Order Liz's new book – How to Age· A Better Second Half· Follow Liz on Instagram· Follow Liz Earle Wellbeing on Instagram Some links may be affiliate links, which help support the show at no extra cost to you. Read our Affiliate Policy for more information. Hosted on Acast. See acast.com/privacy for more information.

Full Show Notes: https://bengreenfieldlife.com/nadplus In this fascinating episode, Dr. Nichola Conlon, molecular biologist and founder of Nuchido, breaks down what NAD actually is, what it does inside your cells, and why most popular strategies for boosting it, including NAD IVs, patches, and high-dose NR or NMN, may be fundamentally flawed based on molecular biology. You’ll discover why NAD declines by half every 20 years, why the NAMPT enzyme and not a shortage of raw material is the real bottleneck, and why flooding the body with precursors without fixing the salvage pathway can actually strain your methylation pathways rather than raise NAD. You’ll also explore how inflammation through the cluster of differentiation 38 (CD38) enzyme silently drains NAD faster than almost anything else, what a gold standard double-blind placebo-controlled crossover clinical trial on Nuchido TIME+ actually showed, and why NAD sits at the intersection of energy production, cellular repair, sleep, skin health, and biological aging. Dr. Nichola Conlon (BSc, MRes, PhD) specializes in cellular aging. After a career in drug development, Dr. Nichola founded Nuchido, driven by her belief that cutting-edge science should not lie hidden. At Nuchido, Dr. Nichola’s work focuses on delivering disruptive innovation in the field of anti-aging, rejuvenation, and healthspan. It has led to the development of Nuchido TIME+, a dietary supplement clinically proven to boost NAD+ and reverse biological age. Unlike standard precursors such as NMN or NR, Nuchido TIME+ uses a systems-based approach to target the root causes of NAD+ decline.

If you don't have energy, you don't have art. Let's talk about how to stay sharp, creative, and energized as you age. Here's something most artists don't think about until it's already a problem … Your body is part of your creative process. If you're exhausted, foggy, and running on empty, it becomes harder to show up, harder to focus, and harder to create consistently. In this episode, I sit down with Alan Graves to talk about longevity, energy, and how to support your body and brain so you can keep making your best work for years to come. We dive into the science behind energy decline, what's happening in your body as you age, and what you can actually do to feel better and think more clearly. Because this isn't about vanity. It's about vitality. Make sure to subscribe to this podcast so you don't miss a thing! And don't forget to come hang with me on Instagram @jodie_king_. Interested in being a guest on a future episode of Honest Art®? Email me at amy@jodieking.com! Resources mentioned: Ready to push your work to Fine Art status? Join me at one of my Honest Art® Workshops - https://jodieking.com/workshop  Ready to make your best art ever, alongside an incredible community of artists? Join us inside the Honest Art Society today! - https://www.jodiekingart.com/has  Don't Miss the Latest from DoNotAge: Get the Cycle Pouches Routine and don't forget to use code SMOKESHOW: https://routine.donotage.org/donotage?ref=smokeshow Visit DoNotAge.Org and use code SMOKESHOW - http://DoNotAge.Org  Jodie loves NMN for NAD Levels (don't forget to use code SMOKESHOW!) - https://donotage.org/pure-nmn  Alan mentions CoQ10 for supporting mitochondrial function … aka making energy (don't forget to use code SMOKESHOW!) - https://donotage.org/pure-coq10  Hyaluronic Acid isn't just for skincare! (don't forget to use code SMOKESHOW!) -https://donotage.org/pure-hyaluronic-acid  Spermidine helps your body's "recycling system" (don't forget to use code SMOKESHOW!) - https://donotage.org/pure-spermidine  Creatine has helped support Jodie's memory (don't forget to use code SMOKESHOW!) - https://donotage.org/creatine  You'll Also Love Episode 104: Secrets for Maintaining Vitality with Alan Graves of Do Not Age - https://jodieking.com/episode-104-secrets-for-maintaining-vitality-with-alan-graves-of-donotage/  Follow DoNotAge on Instagram - https://www.instagram.com/do.not.age/  Follow Alan Graves on Instagram - https://www.instagram.com/alanjackgraves/  Have a question for Jodie? Ask it here: https://forms.gle/hxrVu4oL4PVCKwZm6  How are you liking the Honest Art® Podcast? Leave us a review on your favorite podcast platform and let us know!     Watch this full episode on my YouTube channel: https://www.youtube.com/playlist?list=PLMquJfuMsSg0fr46BRdia1cWd-81GThzF For a full list of show notes and links, check out my blog: www.jodieking.com/podcast  

Welcome to the latest episode of LIFTS, your bite-sized dose of the Latest Industry Fitness Trends and Stories. In this episode, hosts Matthew Januszek and Mohammed Iqbal explore one of the most talked-about topics in modern wellness: NAD and the rapid rise of longevity therapies. Joined by Rachele Pojednic, Chief Science Officer at Restore Hyper Wellness, the conversation breaks down what NAD actually is, how it functions within the body, and why it has become such a focal point in energy, recovery, and healthy aging. As wellness clinics, IV therapies, and performance treatments continue to grow in popularity, NAD has emerged as a central molecule in the conversation around optimisation and longevity. However, as interest increases, so too does the gap between consumer awareness, scientific understanding, and real-world application. The discussion explores the biology behind NAD, including its role in cellular energy production, metabolism, and DNA repair, while also examining the different forms of NAD and its precursors, such as NR and NMN. Matthew and Mo share their own experiences with NAD therapies, opening up a broader discussion around delivery methods, perceived benefits, and the difference between anecdotal outcomes and evidence-based practice. As the conversation develops, Rachel highlights the importance of understanding not just the therapy, but the underlying molecule, and why factors such as dosage, delivery method, and cellular transport play a critical role in determining effectiveness. The episode also addresses the wider challenges within the wellness industry, including the speed at which new therapies are being adopted, the influence of biohacking culture, and the growing need for scientific validation and safety data. For operators, this episode provides valuable insight into both the opportunities and responsibilities associated with integrating longevity and wellness services into fitness environments. In this episode, we cover: What NAD is and how it works in the body Why NAD levels decline with age The rise of NAD and wellness clinics The difference between NAD, NR, and NMN Why delivery method and molecule selection matter The gap between wellness hype and scientific evidence Safety considerations, dosage challenges, and unknowns

Send us Fan MailWrinkles, sagging, and pigment are easy targets because we can see them, measure them, and sell treatments for them. But I keep coming back to a more uncomfortable question: are we actually treating aging, or are we only managing the appearance of aging? In this conversation, I sit down with Dr. Suzan Obagi, a leader in cosmetic dermatology and cosmetic surgery and Associate Professor in Dermatology and Plastic Surgery from the University of Pittsburgh Medical Center and former President of the American Academy of Cosmetic Surgery, to follow the smoke back to the fire and talk about what really drives skin aging and recovery.We break down intrinsic aging versus extrinsic aging and why epigenetics, inflammation, and oxidative stress matter as much as lasers and injectables. Dr. Obagi explains what collagen, elastin, and glycosaminoglycans do, why their production peaks early, and why menopause can accelerate collagen decline. We also get honest about hormone replacement therapy: how estrogen affects skin, mood, joints, vessels, brain health, and wound healing, where risks truly live, and why many women are still mismanaged with symptom-only fixes. If you care about healthspan, longevity, menopause skin changes, and better surgical outcomes, this part will shift your perspective.Then we turn practical. You'll hear the simplest high-yield skincare routine we both rely on: cleansing, well-formulated antioxidants morning and night, moisturizers that support barrier function, mineral sunscreen, and retinoids with realistic timelines for results. We also unpack why some medspa “annual” treatment advice keeps people on a treadmill, and we look ahead at where anti-aging medicine may go next, from rapamycin analogs to NMN to the promise and complexity of Yamanaka factors.If this made you rethink your approach to anti-aging skin care, hormone health, or aesthetic medicine, subscribe, share the episode with a friend, and leave a review so more people can find it.Dr. Suzan Obagi links:Instagram: @suzanobagimdWebsite:http://dermatology.pitt.edu/people/suzan-obagi-mdTweet me @realdrhamrahIG @drhamrah

Send us Fan MailAfter the episode from 2 weeks ago where I covered Protein, creatine etc.  This week I'm tackling some of today's talked-about/hyped supplements and explain why it's crucial to approach them with a healthy dose of skepticism. Promising to clarify the role of trendy options like NAD, NAD+, and NMN, Can boosting naturally declining NAD levels truly reverse aging? And should you trust wellness gurus who pivot from publishing to selling supplements with scant evidence? With non-human studies forming the backbone of much of the current research, you'll hear why investing in healthy lifestyle habits like exercise and diet might be your best bet. I also call out the pattern of wellness figures capitalizing on fleeting trends, urging you to stay informed and cautious about what's genuinely effective for your health. Link to the study I mentionedAs always; HPNB still only has 5 billing cycles. So this means that you not only get 3 months FREE access, no obligation! BUT, if you decide you want to do the rest of the program, after only 5 months of paying $10/£8 a month you now get FREE LIFE TIME ACCESS! That's $50 max spend, in case you were wondering. Though I'm not terribly active on  Instagram and Facebook you can follow us there. I am however active on Threads so find me there! And, of course, you can always find us on our YouTube channel if you like your podcast in video form :) Visit healthypostnatalbody.com and get 3 months completely FREE access. No sales, no commitment, no BS. Email peter@healthypostnatalbody.com if you have any questions, comments or want to suggest a guest/topic      Playing us out; "I've got a whole lot of swing" by Thruline 

We're excited to share another episode in our podcast series featuring heavily vetted companies. Today, I'm delighted to connect with Baran Dilaver. Baran is an entrepreneur, creator, and accomplished executive, and also the co-founder of Wonderfeel Biosciences, a longevity-focused bioscience company that pioneers cellular health innovations through its patented NAD products. (You will likely remember the dynamic interview I did last year with Dr. Andrew Salzman, the MD and Chief Medical Officer of Wonderfeel.) In today's conversation, Baran and I explore the science of cellular energy and its wide-ranging benefits. We cover the physiology of NAD and other nutraceuticals, the key markers of inflammation, and the precursors in Wonderfeel's formulas that enhance absorption and assimilation. We discuss how NAD and creatine monohydrate each fuel cellular energy, their powerful synergistic effects, and the NAD-creatine combination as a powerful midlife stack. We also get into brain fog, mood, and stress resilience, along with the FDA's clarification on NMN and other nutraceuticals, and why NAD injections and IV NAD may fall short compared to oral precursors like NMN and NR. I also share my experience trying Wonderfeel's newest product, Choco Creatine. You won't miss this in-depth conversation with Baran Dilaver of Wonderfeel, as he shares his expert perspective on NAD and creatine monohydrate supplementation. IN THIS EPISODE, YOU WILL LEARN: What recent research from Harvard and MIT has shown about the benefits of increasing NAD levels Why NAD is so essential Baran describes how reduced NAD affects each organ differently How inflammation becomes a key signal of declining NAD levels Why precursors like NMN and NR are necessary for increasing intracellular NAD levels What led Baran to explore how to make NAD compounds more accessible to consumers? How NAD and creatine work synergistically to improve brain and gut functioning How compromised gut integrity drains our energy and forces the body into “overdrive.” Baran outlines the complexities of product development Why ingredients like resveratrol and hydroxytyrosol are included in the Wonderfuel NAD formula Bio: Baran Dilaver Baran is an entrepreneur, creator, and an accomplished executive. He is the Co-founder of Wonderfeel Biosciences, a longevity-focused biosciences company that pioneers cellular health innovations through its patented NAD products. Previously, he led numerous start-ups successfully, served as CEO and COO at public and private companies, where he collaborated with top scientists, visionaries, and medical experts, and developed award-winning products. He is a frequent speaker at conferences like Tech Open Air, Wonderland, and Brandweek. At UC Berkeley, he studied economics and earned athletic and academic scholarships. He gets a special thrill from enhancing people's lives with the products he helps innovate. Baran has been leading the NAD and longevity related initiatives at Wonderfeel Biosciences as its Co-founder and CEO, co-writing a number of patent applications, in vitro and in vivo studies, collecting consumer feedback and helping the Wonderfeel medical team publish peer reviewed papers and by participating high profile interviews and podcasts with the likes of Dr. Mark Hyman and Dave Asprey and speaking at conferences like the Biohacker Summit. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website. Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow. Cynthia's Menopause Gut Book is on presale now! Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line Connect with Baran Dilaver On the Wonderfeel website Previous Episode Mentioned BONUS: Why NAD Matters for Women's Health & Hormones

Learn how fasting, senolytics, and supplements like NMN and honokiol help cleanse cells, kill zombie cells, and reverse aging. #Fasting #Senolytics #Supplements #HealthTalks

Most people think boosting NAD+ is the key to better energy, longevity, and cellular health… but what if that's not the full story?In this episode of Accelerated Health with Sara Banta, I break down a shocking new concern emerging from recent NAD+ research—one that could have serious implications when it comes to cancer risk and uncontrolled cell growth.NAD+ has been widely promoted for anti-aging, metabolism, and mitochondrial function. But here's what most people aren't talking about: increasing NAD+ may also fuel the wrong cells under certain conditions. That's where things get complicated—and potentially dangerous.If you're taking NAD+ boosters, considering NMN or NR supplements, or trying to optimize longevity, you need to understand the full picture—not just the benefits, but the risks.This is not about fear—it's about being informed so you can make smarter, safer decisions for your health.Listen to the full episode to understand: • What the latest NAD+ study actually reveals • How NAD+ impacts both healthy and abnormal cells • Who should be cautious with NAD+ supplementation • What to focus on instead for true, root-cause healthYour health strategy should be based on what actually works long-term—not just what's trending.Listen now and take control of your health with clarity and confidence.Supplements Featured In This Episode:• Acceleradine® Iodine https://www.acceleratedhealthproducts.com/products/acceleradine-iodine-supplement • Accelerated Methylene Blue® https://www.acceleratedhealthproducts.com/products/accelerated-methylene-blue-supplement • Accelerated Liver Care® https://www.acceleratedhealthproducts.com/products/accelerated-liver-care• Accelerated Methylene Blue® https://www.acceleratedhealthproducts.com/products/accelerated-methylene-blue-supplementNot sure what food to eat and avoid? This guide is for you.⬇️

Most people know NAD+ as a supplement trend. But very few understand what's actually happening inside their skin cells when it runs out or what's stealing it in the first place.By the time you're 45, you've lost half of the molecule that powers virtually every function keeping your skin young. Sadly, it only gets worse from there. The enzyme your skin uses for DNA repair can wipe out up to 90% of what's left after a single afternoon in the sun. This isn't a slow, graceful decline. It's a collapse happening beneath the surface long before the wrinkles appear.In this episode, we will nerd out and break down exactly why NAD+ disappears, who the thieves are, and what the science actually says about getting it back. From the sirtuin-PARP-CD38 trifecta to the zombie cell feedback loop that accelerates the drain with age, this is the most complete picture of NAD+ and skin aging we've put together to date.We also cover the real differences between NMN, NR, and niacin, why the precursor you choose actually matters, and what to stack with it to protect your methylation pathways.Ready to nerd out in this with us?Let's dive in!What's Discussed:(4:00) The number that changes how you think about skin aging.(6:03) What NAD+ actually does and why "rechargeable battery" undersells it.(8:18) The three enzyme families consuming your NAD+ as a substrate.(8:23) Sirtuins: the police of your cells and what they cost you.(9:42) PARPs: the fire brigade and why one sunburn nearly wipes you out.(11:16) CD38: the NAD+ Pac-Man that gets worse with age.(15:10) The five-fold decline: what the 2012 tissue study actually found.(16:15) CD38 and the zombie cell feedback loop driving the decline.(19:39) What the depletion actually looks like in the mirror.(28:04) Why NAD+ decline is reversible & supplementation deep dive.(28:41) NMN: how it works and what the studies actually show.(31:50) NR: the most clinically studied precursor and who it's best for.(33:27) Niacin: the $5 option and why most people can't tolerate it.(38:14) Why timing your NAD+ to your circadian rhythm matters.(38:35) TMG and methylation: what to stack and the two-to-one ratio.Learn more about NAD from our previous podcasts and videos:Previous NAD YouTube Videos:NAD+, Skincare Science + The Future of Skincare: https://www.youtube.com/watch?v=ZmwYLywwcsA Biohack Your Way to Better Skin - Benefits of NAD Boosting Supplementation for Skincare & Anti-Aging: https://www.youtube.com/watch?v=KIz5MvW7X1M Why Your NAD+ Supplement Isn't Helping Your Skin | The Truth: https://www.youtube.com/watch?v=euIj0eLt4Aw The Science Behind NAD+, Link Between NAD+ Skin Aging, Importance of Precursors: https://www.youtube.com/watch?v=wmsUeQklYY0 The NAD+ Protocol That Could Reverse Skin Aging (Doctors Won't Tell You) | Dr. Scott Sherr: https://www.youtube.com/watch?v=iYJgVSoj_XM Previous NAD Podcasts:NAD 101: Unlocking The Secrets To Youthful Skin: https://podcasts.apple.com/us/podcast/nad-101-unlocking-the-secrets-to-youthful-skin/id1552026927?i=1000652231123 The Relationship Between NAD+ and Your Skin, NAD+ Depletion, Bioavailability, Precursors, Sirtuins, and More: https://podcasts.apple.com/us/podcast/22-the-relationship-between-nad-and-your-skin/id1552026927?i=1000568088462 The Science Behind NAD+, the Link Between NAD+ and Skin Aging, and the Importance of Precursors: https://podcasts.apple.com/us/podcast/the-science-behind-nad-the-link-between-nad-and/id1552026927?i=1000615122098 Ben Azadi: How NAD+ Helps Reverse Aging + Skin Problems Connected to Deeper Health Issues: https://podcasts.apple.com/us/podcast/ben-azadi-how-nad-helps-reverse-aging-skin-problems/id1552026927?i=1000662495945 Turn Back the Clock: NAD and Skin Biohacking: https://podcasts.apple.com/us/podcast/turn-back-the-clock-nad-and-skin-biohacking/id1552026927?i=1000681105344 Research Studies Mentioned: Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042357 CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30225-7 Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages: https://www.nature.com/articles/s42255-020-00305-3 Enhanced SIRT1 Activity Mitigates UVB-Induced Senescence in Dermal Fibroblasts: https://pubmed.ncbi.nlm.nih.gov/39401943/ Slc12a8 is a nicotinamide mononucleotide transporter: https://www.nature.com/articles/s42255-018-0009-4 The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: https://link.springer.com/article/10.1007/s11357-022-00705-1 Nicotinamide riboside and nicotinamide mononucleotide facilitate NAD+ synthesis via enterohepatic circulation: https://www.science.org/doi/10.1126/sciadv.adl5154 Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults: https://www.nature.com/articles/s41467-018-03421-7 Find more from Young Goose:Use code PODCAST10 to get 10% off your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% off at https://younggoose.comInstagram: @young_goose_skincareHead to younggoose.com/products/youth-body-cream for 20% offBody Cream: Head to younggoose.com/products/youth-body-cream for 20% off

In this episode, Lucas Aoun interviews the co-founders of Verso, Daniel and Christabel, about their innovative approach to health supplements, focusing on sleep, energy, and longevity. They discuss the science behind ingredients like NMN, saffron, Magnesium L-Threonate, and glycine, and share insights into product formulation, standardization, and long-term health benefits.Relevant Links:Get The Sleep Formulation Here (DISCOUNT CODE: LUCAS15):https://evening.ver.so/lucasCheck Out My Website For Coaching, Recommended Products and Much More:https://www.boostyourbiology.com/ Disclaimer:The information provided in this podcast episode is for entertainment purposes and is NOT MEDICAL ADVICE. If you have any questions about your health, contact a medical professional. This content is strictly the opinions of Lucas Aoun and is for informational and entertainment purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult with their doctors or qualified health professionals regarding specific health questions. Neither Lucas Aoun nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this content. All consumers of this content especially taking prescription or over-the-counter medications should consult their physician before beginning any nutritional, supplement or lifestyle program.Chapters00:00 Introduction and guest introduction00:58 Origins of the founders' interest in health and wellness02:17 The story behind starting Verso and NMN03:31 NMN's anti-aging and energy benefits05:20 The impact of modern society on sleep quality06:41 Circadian rhythm and light exposure09:00 Sleep maintenance issues and strategies11:19 Key ingredients for sleep: magnesium, saffron, glycine13:24 Risks of heavy sedatives and the goal of long-term support14:36 Why magnesium is included18:18 The research behind saffron extract and its benefits23:57 The role of glycine and other ingredients in the formula28:09 Flavor, taste, and formulation challenges35:40 Usage instructions and creating a nightly ritual43:27 Product testing, customer feedback, and future plans48:53 The importance of quality ingredients and standardization50:10 Closing remarks and upcoming products Hosted on Acast. See acast.com/privacy for more information.

Send us Fan MailFrom the vault this week, before I do a full episode on the state of postpartum care in the UK next week,In a 2 part episode I am discussing some of the supplements that you might have seen promoted online. Week after next I'll cover NMN, NAD, CBD etc but this week I'm focusing on supplements much more common in the health and fitness world;Protein, Creatine, Vitamins and some bladder supplements (like Jude).Are they safe, even pre and postpartum?Are they useful?Are the more expensive ones really better than cheaper version?Are there alternatives?IOW, should YOU be taking them or are you better off saving your money.As always; HPNB only has 5 billing cycles. So this means that you not only get 3 months FREE access, no obligation! BUT, if you decide you want to do the rest of the program, after only 5 months of paying $10/£8 a month you now get FREE LIFE TIME ACCESS! That's $50 max spend, in case you were wondering. Though I'm not terribly active on  Instagram and Facebook you can follow us there. I am however active on Threads so find me there! Visit healthypostnatalbody.com and get 3 months completely FREE access. No sales, no commitment, no BS. Email peter@healthypostnatalbody.com if you have any questions, comments or want to suggest a guest/topic      Playing us out; "Fallout" by CJ Oliver

Dr. Rhonda Patrick, PhD, is a biomedical scientist and public science educator. She shares the exercise, nutrition, supplementation and lifestyle practices linked to better health and lower disease risk including specific cardio and resistance training routines, when and why to do intermittent fasting, ways to lower visceral fat, omega-3 sourcing, creatine for brain and muscle and peptides such as BPC-157. It's broad and thorough coverage of how to build a total health program tailored to your goals and individual biology. Read the show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Our Place: https://fromourplace.com/huberman Lingo: https://hellolingo.com/huberman LMNT: https://drinklmnt.com/huberman Function: https://functionhealth.com/huberman Mateina: https://drinkmateina.com/huberman Timestamps 00:00:00 Rhonda Patrick (00:02:40) Competition, Jumping Rope, Rope Flow (00:06:49) Rhonda's Exercise Routine, Cardiovascular & Resistance Training (00:12:30) Cognitive & Physical Benefits of Exercise, Serotonin & Impulse Control (00:14:40) Sponsors: Our Place & Lingo (00:17:03) Phones While Training? (00:18:45) Rhonda's Strength Training, Low-Reps, Modifications, Mental Resilience (00:27:00) Daily Protein Intake, Intermittent Fasting, Processed Carbohydrates (00:33:32) Lipopolysaccharide (LPS); Gut Permeability, Gluten; Cardiovascular Health (00:42:58) Sponsor: AG1 (00:44:21) Tight Junctions, Gut, Neuroinflammation (00:47:26) L-glutamine, Immune System, Cancer Risk (00:54:55) N-acetylcysteine (NAC), Vitamin E; Antioxidant Balance, Reductive Stress (01:00:08) Starch, Tool: Bedtime Fast & Cardiovascular Health (01:03:36) Cortisol, Intermittent Fasting Benefits (01:08:09) Cortisol, Train Fasted?; Hormones, Visceral Fat (01:13:35) Visceral Fat, Perimenopause/Menopause, Insulin Resistance in Brain & Body (01:21:13) Sponsor: LMNT (01:22:33) Cortisol & Sleep (01:25:42) Intermittent Fasting, Metabolic Switch, Ketones, Muscle Loss? (01:36:47) Tools: Logic-Based Habits; Daily Metabolic Switch; Exercise, Autophagy (01:45:06) Exercise After Poor Sleep?; Training Breaks (01:52:47) Tool: "Exercise Snacks"; Sedentary Lifestyle & Cardiorespiratory Fitness (02:03:31) Sponsor: Function (02:05:16) Creatine, Dose, Resistance Training, Cognitive Function (02:17:43) Biology; Creatine; Supplement Safety (02:25:18) Omega-3s, Inflammation, Cancer Risk, Vitamin D; Trans Fat (02:36:52) Magnesium Threonate vs Bisglycinate, Sleep, Cognitive Benefit; Vitamin D (02:45:46) Supplement Types, Multivitamin, Coenzyme Q10, Urolithin A, Sulforaphane (02:55:10) Microplastics (02:57:26) Sponsor: Mateina (02:58:28) BPC-157, NMN, NR, Tool: Evaluating Supplements, Safety, Sources (03:06:28) L-Carnitine, Alpha-GPC, Nicotine, GABA & Ketogenic Diet (03:15:20) Nattokinase; Microplastics, Water Bottles; Seed Oils (03:22:21) Sauna, Creatine for Kids?, Bananas, Tool: Evaluating Studies (03:28:37) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

This episode explores what NAD is, why it matters for cellular energy and metabolic function, and why measuring it accurately has historically been so difficult. Guest Jari Närhi explains that NAD is essential for mitochondrial ATP production, DNA repair, inflammation response, and hundreds of metabolic processes, but that low NAD is usually more a consequence of illness, inflammation, or depletion than a root cause on its own. The conversation unpacks the nuance around supplementation, including niacin, NR, NMN, and NAD IVs, while emphasizing that more is not always better and that raising NAD without clear need may not be beneficial. Leigh Ann and Jari also discuss the limits of conventional NAD testing, noting that measuring only NAD+ offers a very incomplete picture compared with looking at multiple NAD forms and their ratios. A major focus of the episode is how NADMED's technology makes it possible for clinical labs to measure several NAD metabolites more reliably and at scale, opening the door for better clinical use and research. Product Discount Codes + LinksJuna: Website (Discount Code: LEIGHANN)Broc Shot: Website (Discount Code: LEIGHANNLINDSEY)Hoolest: Website (Discount Code: THEACCRESCENT10)Guest InfoNADMED - WebsiteJari Närhi - LinkedIn Related EpisodesPodcast Ep. 204: Natalie Samson - Exploring Integrative Genetic Counseling as a Transformative Healthcare ApproachPodcast Ep. 162: Dr. Stephanie Peacock - Unmasking Mold: Mast Cell Activation, Nervous System, Detox & More.Work w/Leigh AnnLearn: What is EVOX Therapy?Book: Schedule a Session or FREE Discovery CallMembership: What is The Healing Alchemy MembershipConnect w/Me & Learn MoreWebsiteInstagramTiktokYoutube

Is your NAD+ supplement actually working against you? Millions of people are taking NMN or NR thinking they're  doing something smart for their longevity. And the science  behind NAD+ is genuinely extraordinary. But the way most  people are supplementing it is incomplete — and there's  growing evidence it could be creating downstream harm most  people never connect back to their supplement. In this episode I break down the full NAD+ story — the  methylation trap, the CD38 drain, why high-dose NMN may be  elevating your cardiovascular risk markers, and what an  intelligent systems-level approach actually looks like. I co-developed NAD+ Next Gen with Peter Lehrke— and in this episode I walk  you through exactly why every ingredient is in the formula. WHAT WE COVER: - The 2023 Nature Cardiovascular Research findings on NMN & ADMA - How high-dose NMN drains your SAM pool and disrupts dopamine,    DNA methylation and homocysteine - CD38 — the biggest NAD+ drain in ageing nobody talks about - The bathtub model: precursors, drains, sirtuin efficiency - Why niacinamide may be smarter than high-dose NMN - EGCG, resveratrol, apigenin, quercetin, rutin — the why    behind each ingredient - 6 practical takeaways including which blood test to get now KEY LINKS: NAD+ Next Gen → https://aevumlabs.co.nz Rejuvenate Pro → https://shop.lisatamati.com Pushing The Limits community → https://www.lisatamati.com GET YOUR HOMOCYSTEINE TESTED: Optimal: below 7–8 µmol/L Above 10 µmol/L: address your methylation cycle urgently Lisa Tamati is a functional health practitioner, longevity  specialist, co-founder of Aevum Labs, host of Pushing The  Limits, and former elite ultra-endurance athlete with 25  years and 140+ ultramarathons across the world's most  extreme environments. Visit Lisa's website  www.lisatamati.com shop.lisatamati.com www.longlifehyperbarics.com www.aevumlabs.co.nz  www.Yourhealthcompass.org www.Myimmuneage.life  Work with Lisa:  

Most people think feeling tired, foggy, and “off” is just what happens with age.But what if the real issue is that your cells are running on less fuel than they used to?In this episode of the Kwik Brain podcast, I sit down with Dr. Andrew Salzman, Harvard-trained physician, inventor, and biomedical entrepreneur, to unpack what's happening at the cellular level when energy drops and your brain stops feeling sharp.We break down NAD, a molecule involved in hundreds of critical reactions in the body, why it declines as you age, and how inflammation can accelerate that decline. We also talk about NMN, and why your brain is often the first place you feel the effects when cellular energy dips.In this episode, you'll learn: ☑️ What NAD does for energy, cognition, and resilience ☑️ Why NAD drops so significantly by midlife ☑️ How NMN works as a precursor to support NAD production ☑️ The “bathtub” model: why boosting NAD is not just about adding more, but also slowing the drain ☑️ How inflammation can drive NAD depletion through CD38 ☑️ Why better cellular energy can translate into clearer thinking, better memory, and sharper focusIf you've been feeling like your brain isn't firing the way it used to, your energy is unpredictable, or your focus is slipping, this episode will help you understand what's happening underneath the surface and what you can do to support your brain at the level where performance actually starts: your cells.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if consciousness doesn't come from the brain… but the brain comes from consciousness?In this extraordinary episode of A Life of Greatness, Sarah Grynberg sits down with filmmaker and creator of The Telepathy Tapes, Ky Dickens, to explore one of the most controversial and mind-expanding conversations of our time.Across years of investigation, Ky uncovered a phenomenon reported by families, teachers and scientists around the world: non-speaking individuals with autism who appear to demonstrate telepathy, precognition and profound spiritual insight.Through spelling-to-communicate methods, these individuals describe a shared telepathic space known as “The Hill,” a place of light, connection and protection where they meet, regardless of physical distance.This conversation explores:• Scientific research into telepathy in both humans and animals• The concept of “The Hill” and collective consciousness• Why many non-speakers speak of angels, God and the afterlife• The idea that consciousness may be fundamental, not produced by the brain• What love, not fear, may actually be the core of human existence• The emotional toll on families and the urgent need for supportThis episode challenges materialism expands the boundaries of science and invites us to reconsider what is possible.If even a fraction of this is true, everything changes.This episode of A Life of Greatness is proudly sponsored by Biohack Wanderlust. Their premium NMN range is designed to support cellular energy, healthy ageing, and nervous system function by boosting NAD+ levels, which naturally decline as we get older. Proudly Australian made and available at Chemist Warehouse, Biohack Wanderlust is helping people take a proactive approach to vitality and longevity. Always read the label and follow the directions for use.Purchase Biohack at Chemist Warehouse hereListen to The Telepathy Tapes herePurchase Sarah's book: Living A Life Of Greatness here.To purchase Living A Life of Greatness outside Australia here or here.Watch A Life of Greatness Episodes On Youtube here.Sign up for Sarah's newsletter (Greatness Guide) here.Purchase Sarah's Meditations here.Instagram: @sarahgrynberg Website: https://sarahgrynberg.com/Facebook: facebook.com/sarahgrynbergTwitter: twitter.com/sarahgrynberg Hosted on Acast. See acast.com/privacy for more information.

Today, I'm joined by the insightful Courtney Van Bussum, a biomedical engineer and entrepreneur who has become a rising force in longevity science. Courtney shares how growing up in a family of healthcare innovators shaped her journey, and how she pivoted from startup life to tackling age-related challenges—especially when COVID brought her back to her roots and reignited her passion for cellular health. If you want to try Endotelio 1-MNA and save 10% click here and code NAT10 will be entered for you at checkout.    Episode Timestamps: Welcome and introduction to Longevity Podcast ... 00:00:00 Challenging beliefs about aging and cellular health ... 00:12:00 Deep dive into NAD+ biochemistry and cellular function ... 00:13:08 NAD+/NADH balance: Why both matter ... 00:15:24 Why NAD+ declines: Not just aging, but increased degradation ...00:18:26 The role of CD38 and NMNT enzymes in NAD metabolism ... 00:20:14 Controversy and confusion: NAD+ precursors (NR, NMN) and IVs ... 00:22:28 Methylation's hidden importance in NAD supplementation ... 00:30:55 Supplementing 1-MNA: Understanding dosages and applications ... 00:50:54 Assessing NAD+ status: Biomarkers and limitations of testing ... 00:53:01 Lifestyle ROI: Sleep, exercise, and circadian rhythm for NAD preservation ... 00:57:14 Ketones: Beyond performance, supporting cellular energy and longevity ... 01:06:03 Future of NAD science: Anticipating new insights and risks ... 01:11:45 Confidence and humility: Advice for navigating the longevity field ... 01:18:52   Our Amazing Sponsors: Qualia Creatine+ by Qualia Life – A clinically formulated blend of two highly bioavailable forms of creatine plus magnesium and electrolytes to support lean muscle, cellular energy, and brain health—especially for women over 40 who naturally produce less with age. Go to qualialife.com/nathalie and use code NATHALIE to save up to 50%, plus an additional 15% off.   Complete Liver Complex by LVLUP Health - supports your liver's natural detox pathways so your body can reset after the holidays without suffering. Go  to lvluphealth.com and use code NAT for 20% off. Gut Essentials Bundle by Just Thrive Health – This powerhouse duo pairs the only probiotic clinically proven to arrive 100% alive in your gut with science-backed Digestive Bitters to reduce bloat, curb cravings, and support better energy fast. Take the Just Thrive Feel Better Challenge and save 20% at justthrivehealth.com/NAT20 with code NAT20.   Nat's Links:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Dr. Bill Lawrence Episode

80% of all autoimmune diseases occur in women, and no one can explain why. Cancer cells are always present in your body, but it's only when your T cells go into energy deficit that cancer starts overtaking the system. And here's what almost no one is talking about: the mitochondria in your immune cells are the reason MS, chronic fatigue, neurodegeneration, and even cancer progression happen when they happen. In this episode, I sit down with Dr. Anurag Singh, MD, PhD immunologist who spent 20 years studying mitochondria and screened 4000 compounds from pomegranates to discover one molecule that changes cellular aging. We break down immunometabolism, the emerging field linking immune health and metabolism, why your T regulatory cells are the CEOs of your immune system, how mitochondrial dysfunction in immune cells triggers autoimmune conditions, and why rejuvenating mitochondria can get your immune system in check to defeat cancer. We also cover NAD+ (and why NMN and NR supplements don't work the way people think), the creatine sweet spot for muscle quality (500mg-1g, not the 5g everyone's taking), why Parkinson's is linked to paraquat, a mitochondrial toxin used in fertilizers and dry cleaning and how AI is fast-tracking the discovery of next-generation molecules for neurodegeneration. This conversation completely shifted how I think about immune health, brain protection, and what's actually driving the diseases we fear most. Reduce your risk of Alzheimer's with my science-backed protocol for women 30+: https://go.neuroathletics.com.au/youtube-sales-page Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. _____ TOPICS DISCUSSED 00:00 Intro: Why 80% of Autoimmune Diseases Occur in Women 01:24 Why Dr. Anurag Became an Immunologist 03:19 Immunometabolism: The Link Between Immune Health and Metabolism 04:20 T Cells, B Cells, and the Thymus Gland 05:51 MS and Autoimmune Disease: The T Regulatory Cell Problem 11:32 Mitochondrial Dysfunction and Immune Exhaustion 18:45 Cancer Cells and T Cell Energy Deficit 24:10 Urolithin A: Screening 4000 Pomegranate Compounds 31:20 Mitophagy and Autophagy: Cellular Housekeeping 38:50 NAD+ vs NMN and NR Supplements: What Actually Works 43:15 Creatine Dosing: The 500mg-1g Sweet Spot for Muscle Quality 48:30 Gut-Brain Connection and Neurodegeneration 50:54 Parkinson's Disease and Paraquat: The Mitochondrial Toxin 53:25 AI in Drug Discovery and Next-Generation Molecules 55:38 Skincare and Mitochondrial Health: Collagen Synthesis _______ Thank you to our sponsors KetoneIQ: https://ketone.com/NEURO for 30% OFF Caraway: Carawayhome.com/neuro10 Jones Road Beauty: https://www.jonesroadbeauty.com - Use code NEURO _______ I'm Louisa Nicola - clinical neurophysiologist - Alzheimer's prevention specialist - founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain- reducing Alzheimer's risk - and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ Learn more about your ad choices. Visit megaphone.fm/adchoices

Are you exercising to look good, but not thinking about how well you'll age?In this episode of A Life of Greatness, Sarah Grynberg sits down with Gabrielle Lyon, a leading voice in muscle centric medicine, longevity and women's health. Recorded in front of a live audience at Wanderlust Wellspring event, this conversation explores how muscle is the organ of longevity and why strength is essential at every stage of life.In this episode, you will learn:• Why women have been deeply underserved when it comes to understanding their bodies• The truth about muscle, ageing, perimenopause and menopause no one properly explained• How protein, carbs and strength training actually support hormones and metabolism• Why building muscle is one of the most powerful tools for resilience, energy and mental clarity• How sleep, supplements and smart training help prevent injury and protect long-term healthThis episode is an invitation to stop fighting your body and start working with it. To see strength not as punishment, but as self respect. And to remember that you are not behind, not broken, and fully capable of becoming stronger from the inside out.This episode of A Life of Greatness is proudly sponsored by Biohack Wanderlust. Their premium NMN range is designed to support cellular energy, healthy ageing, and nervous system function by boosting NAD+ levels, which naturally decline as we get older. Proudly Australian made and available at Chemist Warehouse, Biohack Wanderlust is helping people take a proactive approach to vitality and longevity. Always read the label and follow the directions for use.Purchase Biohack at Chemist Warehouse herePurchase Sarah's book: Living A Life Of Greatness here.To purchase Living A Life of Greatness outside Australia here or here.Watch A Life of Greatness Episodes On Youtube here.Sign up for Sarah's newsletter (Greatness Guide) here.Purchase Sarah's Meditations here.Instagram: @sarahgrynberg Website: https://sarahgrynberg.com/Facebook: facebook.com/sarahgrynbergTwitter: twitter.com/sarahgrynberg Hosted on Acast. See acast.com/privacy for more information.

Today we're diving into the world of NAD⁺—the different ways you can take it, and what really sets each dosage form apart. You've probably seen NAD⁺ IV drips on social media, heard about injections at wellness clinics, maybe you're already taking NR or NMN supplements, and a few weeks ago we talked about NAD⁺ patches.  But what's the real difference between all these delivery systems? Which one works best, which one is worth the cost, and what does the science actually say? Read the Full Episode Transcript: https://pepties.com/nad-ivs-injections-supplements-and-patches/ Related Links/Products Mentioned: Peptide Podcast Partners Page https://pepties.com/partners/ Buy Peptides online at BioLongevity Labs: Use our link and enter COUPON CODE: PEPTIDEPODCAST  at checkout to receive 15% off your total order:  https://go.biolongevitylabs.com/SH5C Momentous Supplements (we use Creatine, Vital Aminos, Whey Protein) https://crrnt.app/MOME/OqGQOxGA LMNT – More Salt, Not Less.  https://elementallabs.refr.cc/default/u/johnjavit Thorne Supplements (we use Omega-3 with CoQ10, Red Yeast Rice, Zinc) https://get.aspr.app/SH1KvW Organifi Creatine and Shilajit Gummies http://rwrd.io/rlbkajm?c MitoZen (methylene blue for Cognitive Function, Anti-Aging, Mental Clarity) https://www.mitozen.com/ref/cnlwiztypt/ For skin and hair health (Copper Tripeptide-1)  Visit Luminose by Entera for an exclusive offer for Peptide Podcast listeners!  ** Promo code PEPTIDEPODCAST at checkout for 10% off an order or 10% off the first month of a subscribe-and-save. ** https://www.enteraskincare.com/?rfsn=8906839.f93c72 NAD+ Push Patch: https://www.pushpatch.com/

Andrew Humberman BioSnap a weekly updated Biography.Andrew Huberman, the Stanford neuroscientist and host of the worlds top health podcast, dropped his latest Huberman Lab episode on February 23, just yesterday, diving deep into restoring youthfulness and vitality to the aging brain and body with guest Dr. Tony Wyss-Coray, a Stanford neurology professor pioneering blood biomarkers for organ health and disease risk, as detailed on the official Huberman Lab site. They unpacked young blood factors, rejuvenation via exercise and fasting, NAD levels, NMN supplements, and how sunlight plus deliberate deep breathing combat accelerated aging—timely stuff with massive long-term implications for anti-aging science that could redefine longevity protocols. No public appearances or business moves popped up in the last few days, but his podcast dominance holds steady, regularly topping charts on platforms like iHeart and Amazon Music. Social buzz simmers too: Food Ingredients First spotlighted Hubermans frequent plugs for hydrogen water as a potential 2026 breakout functional beverage, while STAT News on February 20 quoted him praising nicotine for sharpening the mind, fueling biohacker chatter among influencers like Joe Rogan. Fast Life Hacks updated its February 2026 rundown of his supplement stack—Tongkat Ali, Fadogia Agrestis, omega-3s, and sleep aids like magnesium threonate—based on his recent Rhonda Patrick chat, hinting at tweaks to his testosterone-boosting routine that keep fans dissecting his protocols. No verified headlines scream drama, but this episode rollout cements Hubermans grip on neuroscience gossip, with whispers of premium membership perks like AMA access drawing over a million email subs. All quiet on personal fronts—no unconfirmed rumors or scandals, just pure science fueling the wellness whirlwind.Get the best deals https://amzn.to/3ODvOtaThis content was created in partnership and with the help of Artificial Intelligence AI

What happens when obsession meets purpose, rejection becomes fuel, and your greatest breakdown turns into the foundation for breakthrough?In this episode of A Life of Greatness, Sarah Grynberg sits down with Will Ahmed, founder and CEO of WHOOP. What began as a college athlete's curiosity about overtraining has become one of the world's most influential performance and health platforms, used by elite athletes, leaders, and everyday high performers across the globe.Will shares the real story behind building WHOOP, including early rejection, near financial collapse, panic attacks, and the intense personal cost of scaling a billion dollar company in his early twenties. He opens up about stress, meditation, recovery, sleep, and why mastering your inner world is just as important as mastering your body.In this episode, you will learn:Why obsession, not ideas, is what separates founders who succeed from those who quitHow rejection and self doubt are unavoidable parts of building something meaningfulWhat a panic attack taught Will about stress, leadership, and recoveryWhy sleep and recovery are the hidden drivers of performance and longevityHow meditation became a non negotiable tool for clarity and decision makingWhy greatness comes from doing hard things, not avoiding themThis episode is a powerful reminder that growth lives on the other side of discomfort, and that a life of greatness is built by those willing to listen to their body, face pressure head on, and keep going when it would be easier to stop.This episode of A Life of Greatness is proudly sponsored by Biohack Wanderlust. Their premium NMN range is designed to support cellular energy, healthy ageing, and nervous system function by boosting NAD+ levels, which naturally decline as we get older. Proudly Australian made and available at Chemist Warehouse, Biohack Wanderlust is helping people take a proactive approach to vitality and longevity. Always read the label and follow the directions for use.Purchase Biohack at Chemist Warehouse herePurchase Whoop herePurchase Sarah's book: Living A Life Of Greatness here.To purchase Living A Life of Greatness outside Australia here or here.Watch A Life of Greatness Episodes On Youtube here.Sign up for Sarah's newsletter (Greatness Guide) here.Purchase Sarah's Meditations here.Instagram: @sarahgrynberg Website: https://sarahgrynberg.com/Facebook: facebook.com/sarahgrynbergTwitter: twitter.com/sarahgrynberg Hosted on Acast. See acast.com/privacy for more information.

This week on The Wellness Scoop, we're answering your questions on breakfast smoothies, savoury breakfasts, blood sugar balance and the wellness habits everyone seems to be talking about right now. We unpack whether blending foods like oats and bananas actually changes their nutritional value, take a closer look at glucose-focused eating, ACV shots and food-order hacks, and explain what the evidence really says about managing blood sugar in midlife without extremes. We also discuss celebrity-backed supplements like NMN, what we know (and don't know) about longevity claims, and finish with a calm, evidence-based look at deodorant versus antiperspirant, aluminium fears and how to think about everyday chemical exposure without panic. Send your questions for our weekly Q&A to hello@wellness-scoop.com. Order your copy of Ella's new book: ⁠⁠⁠⁠⁠⁠Quick Wins: Healthy Cooking for Busy Lives⁠⁠⁠⁠⁠⁠ Pre-order your copy of Rhi's upcoming book: ⁠⁠⁠⁠⁠⁠The Fibre Formula⁠⁠⁠⁠ Learn more about your ad choices. Visit podcastchoices.com/adchoices

Your gray hair, thinning lashes, brain fog, and that low energy feeling after 30 might all trace back to one thing: falling NAD and stressed mitochondria. This episode breaks down what actually happens inside your cells as NAD declines, and what you can do about it using specific compounds from mushrooms, olive oil, and even chocolate. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Subscribe and save $15 on Wonderfeel by going to: https://getwonderfeel.com/product/wonderfeel-youngr-nmn/?utm_source=Dave&utm_medium=podcast&utm_campaign=episode2Host Dave Asprey sits down with Baran Dilaver, CEO and co-founder of Wonderfeel Biosciences, to unpack the real science behind NAD, mitochondrial energy, and long-term longevity. Baran is an entrepreneur and inventor who previously led multiple start-ups as CEO and COO, collaborated with leading scientists and medical experts, and developed award-winning products. A UC Berkeley economics graduate and former scholarship athlete, he now focuses on translating cutting-edge bioscience into practical tools that enhance people's lives. They break down how NAD powers mitochondria, why your body strategically allocates cellular energy away from peak cognitive performance as you age, and how stress accelerates that decline. You'll hear the differences between niacinamide, NR, and NMN, the FDA confusion around NMN, and why raising NAD is about cellular repair, resilience, and metabolic function, not just “more energy.” The conversation goes deep on hydroxytyrosol, the powerful olive oil polyphenol that acts as a CD38 inhibitor, and ergothioneine, a mushroom-derived antioxidant with its own receptor in the human body that can accumulate in damaged tissues. Baran shares the origin story that pushed him to research ergothioneine, along with anecdotal observations from long-term users reporting improvements in sleep, focus, energy, thicker hair, reduced gray hair, and even eyelash regrowth. You'll also hear Dave's practical take on ketosis, fasting, supplements, and metabolism, why he prefers NAD precursors over IV NAD for most people, how methyl donors affect NAD IV tolerance, and why Wonderfeelbuilt a creatine chocolate bar sweetened with allulose to stay keto-friendly and diabetic-friendly. This is biohacking grounded in mechanism, from mitochondria and neuroplasticity to anti-aging strategy and smarter supplementation. You'll Learn: • What NAD does in the body and why oral NAD itself is not effective • How niacinamide, NR, and NMN compare as NAD precursors • Why mitochondria control energy allocation, cognition, and resilience • How hydroxytyrosol may support NAD longevity through CD38 inhibition • What ergothioneine is, why it comes from mushrooms, and why the body has a receptor for it • What long-term users commonly report: better sleep, clearer thinking, stronger energy, and cosmetic shifts • Why Dave prefers supplements over NAD IVs in most cases • How allulose differs from other sweeteners and why it matters for metabolism • Why creatine supports brain energy and how heat changes absorption strategy Thank you to our sponsors! • MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order • Branch Basics | Get 15% off at https://branchbasics.com/DAVE15 with code DAVE15 • Timeline | Go to timeline.com/Dave for 20% off• OneSkin | Try OneSkin at https://www.oneskin.co/DAVE and use code DAVE for 15% off Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: NAD supplementation, NMN benefits, NR vs NMN, nicotinamide mononucleotide, mitochondrial function, CD38 inhibition, hydroxytyrosol olive oil, ergothioneine mushrooms, mushroom antioxidant benefits, Alzheimer's prevention strategies, brain fog after 30, mitochondrial energy production, anti aging supplements, longevity compounds, fertility mitochondrial health, NAD IV vs oral NMN, creatine for brain health, allulose sweetener benefits, keto friendly chocolate, GLP 1 natural support, biohacking longevity, neuroplasticity support, metabolism optimization, fasting and NAD levels, ketosis and mitochondria, supplement regulation FDA, functional medicine longevity, Dave Asprey biohacking, Wonderfeel NMN Resources: • Wonderfeel Website: https://getwonderfeel.com/product/wonderfeel-youngr-nmn/?utm_source=Dave&utm_medium=podcast&utm_campaign=episode2• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 - Introduction 01:13 - What Is Wonderfeel 05:31 - NAD and NMN Explained 09:41 - FDA Status of NMN 13:50 - Supplements vs Pharmaceuticals 16:48 - How NAD Powers Mitochondria 25:46 - NAD Benefits and Effects 30:57 - Hydroxytyrosol 35:03 - Ergothioneine 41:55 - Alzheimer's and Brain Health 44:10 - Vitamin D and K2 46:15 - Sustainable Packaging 49:26 - Creatine Bars 51:43 - Allulose Deep Dive 59:28 - Inflammation Research 01:02:15 - Supplement Regulation See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Get access to more than 200 episodes of my premium podcast (The Aliquot) when you sign up as a FoundMyFitness Premium Member Many symptoms attributed to aging are also consistent with chronic inflammatory stress and impaired NAD metabolism. Dr. Charles Brenner explains the mechanisms, the human data, and what interventions actually move the needle. He also cuts through the crowded world of NAD boosters, including oral NAD pills, NMN, NR, and NAD IV drips, clarifying what actually raises NAD in humans and what emerging research suggests about NR for lowering inflammation and improving recovery. Timestamps: (00:00) Introduction (05:36) Why disease states disrupt NAD levels (10:20) How coronavirus infection impacts NAD levels (13:34) Can diet and supplements artificially inflate NAD levels? (15:27) Why blood NAD might not show the full picture (16:59) How obesity and insulin resistance drain NAD resources (19:40) Does poor sleep disrupt NAD levels? (20:32) The anti-inflammatory effects of nicotinamide riboside (NR) (25:17) Can a single lifestyle change restore NAD? (28:01) Cognitive benefits of NAD precursors (31:37) Should you measure your NAD levels? (34:37) Does exercise boost NAD—and if so, which type? (36:39) Can NAD precursors speed exercise recovery? (39:14) Is acute sleep loss enough to lower NAD? (40:46) Does NR supplementation during pregnancy benefit offspring? (45:21) Safety of nicotinamide riboside during pregnancy (47:27) Could NR supplementation support fertility? (48:37) Shift work and jet lag—can NAD precursors help? (51:19) Morning or night—when should you take NR? (54:20) NAD supplements vs. precursors—what actually boosts NAD? (58:07) NAD IV drips—real benefits or just hype? (59:15) Oral vs. IV nicotinamide riboside—what's more effective? (1:00:44) Do oral NAD supplements genuinely raise NAD levels? (1:02:37) NMN vs. NR—does being 'one step closer' really matter? (1:05:44) Does the gut microbiome influence NAD production? (1:08:22) Could NR supplementation enhance immune function? (1:11:41) Can NR supplementation improve peripheral artery disease? (1:16:05) Can NR realistically reduce liver fat? (1:21:12) Does NR supplementation give athletes a recovery edge? (1:22:57) What's a safe dosage for nicotinamide riboside? (1:25:00) Resveratrol and pterostilbene—beneficial pairing or pointless stack? (1:26:35) NAD precursor supplements—why sourcing matters (1:28:48) Do NAD precursors increase cancer risk? (1:34:34) Is NR worth supplementing for healthy individuals? (1:38:56) From enzyme nerd to NAD pioneer (Brenner's origin story) (1:43:26) Simplifying NAD's role in energy and repair (1:50:13) Why DNA repair depends heavily on NAD (1:52:03) The PARP/NAD-consumption mechanism (1:54:42) NAD's role in gene regulation (1:57:02) Why NAD shortages hit the brain hardest Show notes are available by clicking here Watch this episode on YouTube

Boosting a Natural Molecule (NAD+) Reverses Alzheimer's Brain Damage in New Study University of Oslo & Ullevaal University Hospital (Norway), February 8, 2026   One of the key drivers of brain dysfunction in Alzheimer's disease (AD) is the protein tau. Under normal conditions, tau helps maintain the internal structure of neurons, supporting the transport systems that allow nerve cells to function properly. In Alzheimer's disease, however, tau becomes abnormally modified and begins to clump together. These aggregates interfere with normal cellular transport, damage neurons, and ultimately contribute to memory impairment. Now, an international team of scientists has identified a previously unrecognized way to protect the brain from this degeneration. Their research shows that increasing levels of the naturally occurring molecule NAD⁺ can counteract neurological damage linked to Alzheimer's disease.  Previous research has suggested that boosting NAD⁺ using precursor compounds such as nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN) can produce beneficial effects in animal models of AD and in early-stage clinical studies. However, the biological processes responsible for these effects have remained poorly understood,” explains first author Alice Ruixue Ai. The new study reveals that NAD⁺ works through a previously unidentified RNA-splicing pathway. This pathway is regulated by a protein called EVA1C, which plays an essential role in the process of RNA splicing. RNA splicing allows a single gene to produce multiple isoforms of a protein, and one isoform may show distinctive effects on the other isoforms. Its dysregulation is one of the most recently acknowledged risk factors for AD.        

In this episode, Prof Chapman explains why there is currently no proven treatment that can reliably increase egg numbers or embryo yield in an IVF cycle, despite bold claims about supplements and therapies. He unpacks the limits of current science, addresses popular compounds like NMN, and emphasizes why lifestyle factors, realistic expectations, expert care, and emotional support matter far more than chasing unproven solutions. The discussion also explores what truly separates an excellent IVF clinic from a technically good one, personalized care, honest guidance, and support through repeated setbacks. Explore the 'Prof. Michael Chapman - The IVF Journey' Facebook Page, your reliable destination for cutting-edge insights and guidance within the realm of In Vitro Fertilization (IVF). Don't miss out on the IVF Journey podcast; stay informed with the latest episode updates. Tune in for expert discussions and valuable information on navigating the intricate path of IVF.

Most people think they go into your body and make all new tissue… but in actuality, they are a delivery mechanism of growth factors. I call them the ultimate traffic cop. In this episode, the host converses with Dr. Jesse Morse, a physician specializing in regenerative and anti-aging medicine. They delve into the intricacies of stem cells and their various sources, including bone marrow, fat, and donor tissue.  Dr. Morse highlights the role of exosomes and growth factors in the healing process. The discussion also focuses on the prevention and treatment of Achilles tendon tears, emphasizing the importance of blood supply, proper diagnosis, and innovative therapies. Additionally, they explore the benefits and applications of various peptides, including BPC 157, TB 500, and MotC, for enhancing healing, anti-aging, and overall health. Dr. Morse also addresses the significance of nutrition and detoxification in maintaining optimal health and preventing injuries. Dr. Jesse Morse is a Miami-based, double board-certified physician in Family and Sports Medicine who specializes in regenerative medicine, injury recovery, and longevity. Since shifting from traditional sports medicine in 2020, he has focused on non-surgical approaches to tendon and ligament injuries using therapies like PRP, stem-cell–based treatments, exosomes, and peptides, alongside functional and anti-aging strategies centered on mitochondrial health, immune support, toxin reduction, and personalized recovery—helping everyone from active adults to high-performance athletes restore function and prevent major injuries like Achilles tears while educating widely online. Connect with him on: Instagram: https://www.instagram.com/drjessemorse/ — Sports medicine, regenerative medicine & insights Linktree (aggregated links to socials & resources): https://linktr.ee/DrJesseMorse   Supplements, Compounds & Peptides Collagen (protein / connective tissue support): https://www.ncbi.nlm.nih.gov/books/NBK507922/ Vitamin C (collagen activation / antioxidant): https://ods.od.nih.gov/factsheets/VitaminC-HealthProfessional/ Creatine (muscle & mitochondrial support): https://ods.od.nih.gov/factsheets/Creatine-HealthProfessional/ BPC-157 (peptide – tendon & gut healing): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504390/ TB-500 / Thymosin Beta-4 (peptide – tissue repair): https://pubmed.ncbi.nlm.nih.gov/22674782/ GHK-Cu (copper peptide – skin, joints, stem-cell signaling): https://pubchem.ncbi.nlm.nih.gov/compound/GHK-Cu MOTS-c (mitochondrial peptide): https://pubmed.ncbi.nlm.nih.gov/25174616/ SS-31 / Elamipretide (mitochondrial peptide): https://pubmed.ncbi.nlm.nih.gov/29515116/ Thymosin Alpha-1 (immune modulation peptide): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367996/ LL-37 (antimicrobial / immune peptide): https://pubmed.ncbi.nlm.nih.gov/15184378/ 5-Amino-1MQ (NNMT inhibitor / fat loss): https://pubchem.ncbi.nlm.nih.gov/compound/5-Amino-1MQ N-Acetylcysteine (NAC – liver & detox support): https://www.ncbi.nlm.nih.gov/books/NBK537183/ Glutathione (antioxidant / detox): https://ods.od.nih.gov/factsheets/Glutathione-HealthProfessional/ NAD⁺ / NMN / NR (mitochondrial & anti-aging support): NMN: https://pubchem.ncbi.nlm.nih.gov/compound/Nicotinamide-mononucleotide NR: https://pubchem.ncbi.nlm.nih.gov/compound/Nicotinamide-riboside Regenerative & Injection Therapies PRP – Platelet-Rich Plasma: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990861/ Bone Marrow–Derived Stem Cells (BMAC): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630382/ Adipose-Derived Stem Cells: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416130/ Amniotic / Placental Tissue Products: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124018/ Exosomes (cell signaling vesicles): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8465611/ Ultrasound-Guided Injections: https://radiopaedia.org/articles/musculoskeletal-ultrasound-guided-injection Needle Tenotomy (scar-tissue disruption): https://pubmed.ncbi.nlm.nih.gov/30428129/ Detox, Blood & Environmental Interventions Sauna (heat detox & cardiovascular benefit): https://www.health.harvard.edu/staying-healthy/saunas-and-your-health Binders – Modified Citrus Pectin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452227/ GI Detox / Toxin Binders (general concept): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654245/ Heavy Metal Chelation (DMPS concept): https://pubmed.ncbi.nlm.nih.gov/12198644/ Mercury Toxicity: https://www.cdc.gov/mercury/index.html Microplastics in Humans: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068600/ EBOO Therapy (ozone-based blood filtration): https://pubmed.ncbi.nlm.nih.gov/36681461/ Therapeutic Plasma Exchange (TPE): https://www.ncbi.nlm.nih.gov/books/NBK557561/ INUSpheresis (advanced plasma filtration): https://pubmed.ncbi.nlm.nih.gov/37324197/ Medications & Drug Classes Mentioned Corticosteroids (Prednisone – tendon risk): https://medlineplus.gov/druginfo/meds/a601102.html Fluoroquinolone Antibiotics (tendon rupture risk): https://www.fda.gov/drugs/drug-safety-and-availability/fda-updates-fluoroquinolone-antibiotics GLP-1 Agonists (Semaglutide / Tirzepatide / Retatrutide discussion): Semaglutide: https://pubmed.ncbi.nlm.nih.gov/36421543/ Tirzepatide: https://pubmed.ncbi.nlm.nih.gov/35220624/ Nutrition & Food-Related Mentions Protein Intake & Muscle Health: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566799/ American Gluten vs European Wheat: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8799814/ Seed Oils & Inflammation (discussion topic): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196963/ Dairy & Inflammation (contextual mention): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122229/ Key Mechanisms & Concepts Poor Blood Supply in Achilles Tendon (Watershed Zone): https://pubmed.ncbi.nlm.nih.gov/17021202/ Mitochondrial Dysfunction & Aging: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843959/ Stem Cells as "Medicinal Signaling Cells": https://pubmed.ncbi.nlm.nih.gov/25784997/   Show Notes 00:00 Introduction to Exosomes and Stem Cells 01:01 Dr. Morse's Background and Transition to Regenerative Medicine 02:03 Achilles Tendon Tears: Causes and Prevention 05:02 Preventative Measures and Treatments for Achilles Injuries 10:26 The Role of Nutrition in Tendon Health 12:53 Peptides and Their Impact on Tendon Health 15:50 Stem Cells: Misconceptions and Applications 20:52 Comparing Stem Cell Sources and Their Potency 29:52 The Controversy of International Stem Cell Treatments 34:04 Cleaning Toxins from Your Blood 34:19 The Toxic Burden in Our Environment 35:57 Practical Detox Methods 37:47 Mercury and Heavy Metal Testing 44:47 The Problem with American Gluten 46:49 Underrated Peptides for Health 53:42 Growth Hormone and Anti-Aging 01:03:34 Advanced Blood Cleaning Techniques 01:04:51 Conclusion and Contact Information   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

He quit Amazon, then launched One TikTok Shop SKU to 7-figures. Our guest breaks down content systems, creator outreach, FBT, cash flow, and scaling his product into the US.

NAD has become one of the most talked-about molecules in longevity medicine—showing up in supplements, IV clinics, lab testing, and bold claims about aging and healthspan. But what does the science actually show?In this episode of The Trip Lab, we take a clear, evidence-based look at NAD and use it as a lens to explore the broader field of longevity medicine. We break down what NAD does in the human body, why it's linked to the hallmarks of aging, and why declining NAD is often a signal of cumulative cellular stress rather than a simple deficiency.We also dive into the realities of NAD testing, the limitations of blood-based biomarkers, and what clinical trials of NR and NMN supplementation have—and have not—demonstrated so far. Along the way, we unpack why longevity research is both exciting and vulnerable to overhype, and why translating aging biology into meaningful human outcomes takes time.This episode is for anyone curious about longevity medicine who wants clarity without hype—and a better framework for thinking about promise versus proof.

Carolina Reis Oliveira, PhD and co-founder of OneSkin (code: BIOHACKINGBRITTANY), exposes why so many "anti-aging" products quietly inflame your skin, accelerate cellular aging, and wreck your barrier — and what a true longevity-first skincare routine looks like instead. We unpack senescent "zombie cells", exosome facials, NAD+ creams, rating apps like EWG and Yuka, and how to choose products that are both clean and clinically effective without overloading your skin. As a mom and longevity nerd, I also ask her how women can simplify their routines without sacrificing results, especially when we're juggling babies, work, and sleep. Join my 12 Holiday Rituals Giveaway for a chance to win part of $5,500+ USD in wellness prizes. Open until December 24th! WE TALK ABOUT:  02:00 - Why OneSkin started by testing popular "anti-aging" creams on real human skin 10:35 - What senescent "zombie cells" are and why they act like rotten apples inside your skin 14:15 - Why OneSkin keeps its OS-01 peptide topical (not oral) and what that means for safety vs. supplements 17:45 - Exosome facials, plant stem cell exosomes, and how to tell if what's in the vial is actually still active 19:15 - NAD, NMN, niacinamide and so-called "mitochondria" creams — what the data really shows on skin aging 25:55 - The kinds of clinical tests and lab data Carolina looks for before she'll trust a formula 31:05 - Exactly where OneSkin fits into your routine with vitamin C, retinol, eye creams and exfoliants 34:05 - Non-comedogenic formulas, coconut oil breakouts and how OneSkin formulates for acne-prone skin 39:15 - How to actually use a gua sha for lymph drainage, jaw tension and lip lines  40:35 - The future of longevity: Shifting from "anti-aging" to extending women's healthspan and vitality into our 70s and 80s 43:40 - Hormone therapy, prevention and why "just get used to it, you're getting old" is a dangerous narrative 45:40 - How to spot longevity greenwashing in both skincare and supplements RESOURCES: Free gift: Download my hormone-balancing, fertility-boosting chocolate recipe. Explore my luxury retreats and wellness events for women. Shop my faves: Check out my Amazon storefront for wellness essentials. OneSkin's website (code: BIOHACKINGBRITTANY) and Instagram Join my 12 Holiday Rituals Giveaway before December 24th LET'S CONNECT: Instagram, TikTok, Facebook Shop my favorite health products Listen on Spotify, Apple Podcasts, YouTube Music

Thank you for joining us for our 2nd Cabral HouseCall of the weekend!   I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Sheena: Hi Dr. C! Hope you and your team are all well. I've been a long time follower and am trying my best to incorporate all the different ways to stay healthy by following the Rain Barrel protocol. When it comes to detoxing, besides exercise and the 7-21 day detox, I dry brush, rebound and now, would like to start invest in a IF sauna. My question is, even though dry brushing and rebounding is only 5-15 mins, do I still need to do it if I get a sauna? I'm trying to save time anywhere I can. Also, regarding IF sauna, which do you prefer? The Thera360? Or Higher Dose IF Sauna Blanket? I've listened to all your podcasts that review them and they both sound great. But is there a "better" one between the two? Thanks in advance for your answer!                                                                                                                                        Kirsty: Hi Stephen, I recently came across some information suggesting that resveratrol might be estrogenic. I was hoping you could clarify whether that's true. I've been taking it alongside NMN, but now I'm a bit concerned it might not be as beneficial as I initially thought. Thanks so much for all you do, I love and trust your information. Kirsty             Tricia: Good morning Dr Cabral - I have a problem that I just can't see to conquer and I know if I don't I will never reach my health goals. Every night at 8pm like clockwork I want to eat. It doesn't matter what time I have dinner or what I eat for dinner. I believe it might be a habit but I can't seem to break it. I will use strong willpower for a few months start to lose weight and feel great and then my willpower gives in and I'm back to a snack at 8pm then my health start to spiral. It makes me sad that I can't win this battle. I listen to you everyday and you have helped me SO much. I just can't seem to break this vicious cycle. Do you have any advice? I go to bed early because I get up at 4:00am so I try to eat dinner at 4:30pm. Thank you!                                                                                                                                                              Tricia: Hi it is me again. I also do well with routine and I remember on one of your podcast you mentioned you tend to eat the same foods during the week to keep it simple. Do you mind sharing your meal plan for during the week. I need simple and routine. Also, on Monday do you still do a reset day most weeks? Thank you for taking the time to record these podcasts.                                                                                        Amy: I'm interested in getting the food sensitivity test for my 6 year old daughter. Is it something I can use for her (is there an age restriction)? Is it an at home urine test? Thank you         Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right!   - - - Show Notes and Resources: StephenCabral.com/3572 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

On this episode of Vitality Radio, Jared dives deep into one of the most fascinating frontiers in functional nutrition—brain energy. He unpacks how ATP fuels your mind, why BDNF acts like “fertilizer for neurons,” and how lifestyle stressors, toxins, and poor sleep can dim your mental lightbulb. From there, he explores the natural tools that can reignite focus, memory, and long-term cognitive vitality. You'll hear how powerhouse nutrients can support mitochondrial performance, boost brain-derived neurotrophic factor, and promote sharper thinking—without the crash of caffeine or pharmaceuticals. Jared wraps up with three practical, results-driven protocols: one for focus and ADHD support, one for immediate memory and cognition, and one for long-term prevention of cognitive decline. Each stack can be customized to fit your individual goals so you can think clearer, focus longer, and age smarter—naturally.Brain Boosting Protocol CollectionShop the collection! Bundle and save - no code needed, just add to your cart to get:Buy 2 at 10% offBuy 3-4 at 15% offBuy 5+ at 25% offAdditional Information:Brain Boosting Protocol Blog Post#335: The Latest Research on Preventing and Reversing Dementia and Alzheimer's with Dr. Dale Bredesen#570: Liquid Yoga & Mind Fuel: Harnessing Mushrooms and Herbs for Focus and Calm#511: Unraveling NAD+ and NMN for Longevity and Anti-AgingVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

This episode originally aired as #511 on 2/22/25 and we are bringing it to you again! NAD+, NMN, NR, Longevity…these buzz words have been making the rounds, but what do they mean and why are they important? On this episode of Vitality Radio, Jared breaks it down as he discusses how all of these factor into anti-aging. You'll learn how NAD+ is essential for energy production, DNA repair, and more - and how you can boost your body's production of it by supplementing with NMN. The conversation delves into the roles of sirtuins in cellular health, metabolism, inflammation, cognition, and overall aging. Products:Vitality Nutrition Vital NMNAdditional Information:#497: The Vital Role of Glutathione and How to Deliver it to Your Cells with Dr. Nayan PatelVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful and @vitalityradio on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

In this Huberman Lab Essentials episode, my guest is Dr. David Sinclair, PhD, a professor of genetics at Harvard Medical School and a leading expert on the biology of aging. We discuss the cellular and molecular mechanisms of aging—and how specific behaviors, such as fasting, regular exercise and NAD⁺-boosting compounds like NMN, can activate the body's natural longevity pathways. This discussion highlights how lifestyle choices profoundly influence the aging process and may even slow or reverse key aspects of biological aging. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AGZ by AG1: https://drinkagz.com/huberman David: https://davidprotein.com/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps (0:00) David Sinclair (0:20) Longevity, Anti-Aging, Aging as a Disease (2:27) Causes of Aging; Epigenome & Genes (4:53) CD & Scratches Analogy, DNA, Silencing & Expressing Genes (6:44) Physical Appearance & Aging (7:36) Sponsor: David (8:54) Childhood Development & Aging, Horvath Clock, Accelerate Aging (11:30) Rates of Puberty & Aging, Growth Hormone (12:37) Body Size & Longevity; Epigenetics (13:07) Fasting, Calorie Restriction & Longevity, Sirtuins, Insulin & Glucose (16:31) Tool: Skip a Meal (17:07) Longer Fasts & Autophagy, “Deep Cleanse” (18:07) Sponsor: AGZ by AG1 (19:36) Fasting, Fluids, Electrolytes (20:16) Sirtuins, Glucose, mTOR & Fasting; Leucine, Tool: Pulsing Behaviors (24:24) Breaking a Fast, Tools: Do Your Best; Transitions (27:00) Sirtuins, NAD, NMN Supplementation (29:04) Sponsor: Eight Sleep (31:10) Iron & Senescent Cells; Personalize Medicine (32:40) Tool: Blood Markers, CRP (34:50) Tool: Aerobic & Resistance Exercise (35:55) Estrogen, Fasting & Fertility; Aging & Rejuvenation (38:20) Acknowledgements Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Upgrade your week in just 10 minutes with D(AI)ve Asprey's essential rundown on what matters most in longevity, biohacking, AI health tech, and medical freedom. This episode covers: • Apple Cider Vinegar Myth Busted A weight-loss study just got retracted. ACV will not melt fat, but it may blunt glucose spikes or ease digestion when diluted in water before carb-heavy meals. Skip the shots and protect your teeth. Source: https://www.sciencedaily.com/releases/2025/10/251001092216.htm • NMN Is Back The FDA reversal puts NMN back on shelves as a clean NAD precursor. Dave explains why quality, cycling, and stacking with anti-inflammatory strategies make the difference. Source: https://www.prnewswire.com/news-releases/renue-by-science-celebrates-fda-reversal-confirming-nmn-is-lawful-for-use-in-dietary-supplements-302573317.html • Poor Sleep Ages Your Brain Machine learning MRI studies show poor sleep makes your brain biologically older and raises dementia risk. Dave shares the three dials to track (deep sleep, REM, resting heart rate) and the three biggest levers to fix them. Source: https://www.sciencedaily.com/releases/2024/10/241023171543.htm • Psilocybin for Lasting Reset New research finds a single guided dose can unlock plasticity, ease pain patterns, and lift mood for weeks. Dave outlines safe protocols, integration steps, and why it is a strategic reset tool, not a party trick. Source: https://www.sciencedaily.com/releases/2025/06/250616040215.htm • AI Detects Cancer Earlier A new AI tool called DOLPHIN can find hidden genetic markers to flag cancer risk sooner. Pairing high tech scans with low tech terrain fixes like sleep, muscle, and insulin control is the prevention model that works. Source: https://www.sciencedaily.com/releases/2025/10/251001092206.htm All source links provided for easy reference to the original reporting and research above. This is essential listening for fans of biohacking, hacking human performance, functional medicine, and longevity who want actionable tools from Host Dave Asprey and a guest who embodies what it means to age with energy, clarity, and vitality. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Apple cider vinegar, weight loss myths, NMN supplements, NAD precursors, cellular energy, sleep and dementia, brain aging, deep sleep optimization, REM sleep, psilocybin therapy, BDNF, neuroplasticity, pain relief, mood reset, AI cancer detection, early cancer screening, biohacking news, longevity science, Dave Asprey, Human Upgrade podcast Thank you to our sponsors! Screenfit | Get your at-home eye training program for 40% off using code DAVE https://www.screenfit.com/dave. LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser. Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave. Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Introduction 0:18 — Story 1: Apple Cider Vinegar and Weight Loss 1:49 — Story 2: NMN is Back in Supplements 3:31 — Story 3: Sleep and Brain Health 5:39 — Story 4: Psilocybin and Lasting Relief 7:49 — Story 5: AI Tool DOLPHIN for Early Cancer Signals 9:48 — Conclusion & Weekly Roundup See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Learn how to slow, and even reverse, your biological age with cutting-edge science on the molecule that controls your longevity. Host Dave Asprey sits down with Dr. Leonard Guarente, an MIT PhD and one of the most respected longevity researchers in the world, to reveal how NAD+, sirtuins, and DNA methylation clocks can help you hack aging, upgrade your mitochondria, and extend your healthspan. This episode gives you the real science, proven by over 250 studies, behind supplements, nutrition, and biohacking tools that actually work for brain optimization, metabolism, and human performance. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR You'll learn why NAD+ is a master regulator of mitochondrial health, how DNA methylation clocks accurately measure biological age, and why boosting sirtuin activity improves resilience, neuroplasticity, and recovery. Dr. Guarente shares insider strategies from decades of functional medicine research, including nootropics, targeted supplements, fasting protocols, and diet adjustments from carnivore to Mediterranean that can shift your metabolism toward longevity. Dave and Dr. Guarente explore advanced biohacks like cold therapy, sleep optimization, and ketosis, plus how to balance these interventions with your genetics, lifestyle, and health goals. You'll also hear about the surprising role of homocysteine in brain aging, how to use lab testing to guide your longevity plan, and why resilience is the ultimate measure of health. You'll learn: • How emotional repression affects brain function, metabolism, and decision-making • Tools for nervous system regulation and emotional healing that drive high performance • Why most people fail without emotional intelligence and internal safety • How somatic awareness can optimize your energy, focus, and relationships • The science of fear, trauma release, and how to turn discomfort into growth • How to coach yourself out of stress, shame, and negative self-talk Whether you want to sharpen your brain, protect your heart, or upgrade your energy systems, this is a masterclass in smarter not harder biohacking for a longer, higher-performing life.Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: NAD+ supplementation, Sirtuin activation, DNA methylation clocks, Biological age testing, Mitochondrial biogenesis, Epigenetic reprogramming, Pterostilbene benefits, Nicotinamide riboside (NR), Nicotinamide mononucleotide (NMN), Homocysteine reduction, Oxidative stress repair, Superoxide dismutase (SOD) activation, Functional medicine longevity, Healthspan optimization, Resveratrol bioavailability, Menopause mitochondrial support, Phenylbutyrate and protein folding, High-fat diet longevity studies, Neurodegenerative disease biohacking, INCHIANTI aging study Thank you to our sponsors! Screenfit | Get your at-home eye training program for 40% off using code DAVE https://www.screenfit.com/dave. Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. Resources: • Elysium Website. Use code ‘UPGRADE25' for 25% off the first month of a monthly subscription to any Elysium supplement: https://www.elysiumhealth.com/ • Dave Asprey's Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Introduction to NAD & Sirtuins 0:59 — Intro 7:04 — Animal vs Human Aging Studies 10:07 — Discovery of Sirtuins 14:43 — NAD's Role in Aging 15:34 — Resveratrol vs Pterostilbene 23:13 — Timing NAD Supplementation 36:34 — Diet & Lifestyle Factors 50:05 — Elysium's Basis & Signal 1:00:03 — Future Clinical Trials 1:05:14 — Psychology of Aging & Wrap-Up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The Silent Killer of the Mind: What You Don't Know About Alzheimer's Could Be Hurting You Already What if the path to Alzheimer's doesn't begin in your 70s—but is already unfolding in your 30s, 40s, or even earlier? In this powerful conversation with Dr. Robert Love, we expose one of the most misunderstood, underestimated health threats of our generation—Alzheimer's disease—and what you can do today to not only prevent it, but potentially reverse its early effects. I've had some of the best minds on this show, but Dr. Love stands out. He's not just brilliant—he's a world-class communicator on a mission to bring hope, tools, and clarity to one of the scariest topics out there: losing your mind. Dr. Love pulls back the curtain on the real causes of Alzheimer's—and it's not just genetics. It's inflammation. It's sugar. It's chronic stress. It's poor sleep. He explains how our modern lifestyle is sabotaging our brain health decades before symptoms appear. And here's what hit me hard: your inflammation levels at age 40 are one of the strongest predictors of your Alzheimer's risk at 70. That's not fear—that's a wake-up call. But the best part? We're not powerless. From simple lifestyle shifts to breakthrough supplements like lion's mane and curcumin, Dr. Love shows us the map to protecting the most vital organ we've got—our brain. We also dive into cutting-edge science that isn't just about prevention—it's about reversal. Dr. Love shares promising new treatments and even clinical results from his medical clinic where Alzheimer's symptoms have improved or stabilized through non-drug protocols. He gives us a first-hand account of a patient who went from disoriented and forgetful to alert, clear, and sharp—all within six months. I'm telling you, this isn't science fiction. This is the new frontier of brain health. Beyond the data and science, what really resonated with me was this: so much of what protects the brain is also what builds a better life—quality sleep, exercise, meaningful learning, low stress, good food, and strong relationships. Dr. Love reminds us that joy, curiosity, and purpose aren't just nice-to-haves—they're biological armor for your brain. And if you're young and thinking this episode doesn't apply to you? Think again. The decisions you make today will echo into the quality of your future decades. Key Takeaways: Alzheimer's starts decades before symptoms appear—your 40s matter Inflammation is one of the biggest risk factors for cognitive decline Sleep, gut health, stress, and sugar all have massive impacts on brain aging Supplements like lion's mane, curcumin, and NMN can support neurogenesis Alzheimer's symptoms can be improved or reversed with lifestyle interventions Your lifestyle is not just shaping your body—it's shaping your brain This one is a must-listen. Share it with someone you love. This information can change lives. — Max Out