Podcasts about phd

Your blindspots and biases block your success and happiness. Here's how to navigate that. Dr Kirstin Ferguson AM is an award-winning leadership expert, author and columnist, ranked among the top 50 management thinkers in the world. Her career began in the Royal Australian Air Force and includes roles as CEO of a global consultancy and Acting Chair of the ABC. She holds a PhD in leadership and culture, writes the popular 'Got a Minute?' column in The Sydney Morning Herald and The Age, and is a Member of the Order of Australia.  In this episode we talk about: The concept of blindspotting – what it is and how to do it The power of intellectual humility and how to practice it The difference between seekers and knowers – and when each mindset is useful The three major thinking traps How to disentangle ego from identity, manage defensiveness, and turn feedback into growth The role of curiosity in finding truth, building psychological safety, and leading more effectively How to "read the room" in workplaces, relationships, and global contexts  The key to good leadership The importance of modeling uncertainty as a leader Join Dan's online community here Follow Dan on social: Instagram, TikTok Subscribe to our YouTube Channel To advertise on the show, contact sales@advertisecast.com or visit https://advertising.libsyn.com/10HappierwithDanHarris Thanks to our sponsors:  AT&T:   Happy Holidays from AT&T. Connecting changes everything. Function:  Visit www.functionhealth.com/Happier or use the gift code Happier25 for a $25 credit towards your membership.

Patreon | Episodes | Subscribe | Spotify | YouTube | Newsletter | Contact | Swag! | CME Show Segments Intro Case: Jeremy Wearable devices inaccuracies Ideal blood pressure measurement Diagnosis and workup Management and fixed-dose combination pills Case: Jolene and pregnancy Outro Credits Written and Produced by: Deborah Gorth MD, PhD Infographic and Cover Art by: Deborah Gorth MD, PhD and Meryl Gorth RD, MPH Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP    Reviewer: Emi Okamoto MD Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP Technical Production: PodPaste Guest: Jordana Cohen MD, MSCE Disclosures Financial Relationships disclosed for Dr. Jordana Cohen: Wolters Kluwer (Royalties or Patent Beneficiary) and National Institutes of Health (Grant or research support) Sponsor: FIGS We've teamed up with FIGS, and now Curbsiders listeners can get 15% off. Just go to WearFIGS.com and use code FIGSRX.   Sponsor: MasterClass MasterClass always has great offers during the holidays, sometimes up to as much as 50% off. Head over to masterclass.com/CURB for the current offer. Sponsor: Quince Go to Quince.com/curb for free shipping on your order and 365-day returns.

Sarah is back from Mexico, and she has tales to tell! It was a White Lotus scenario with a little jellyfish run-in on the side. Susie watched The Stringer documentary about the Napalm Girl Pulitzer Prize winning photograph, and the recent controversy about who took the picture. We learn about a 30 year study on the language used in obituaries, and what it can teach us about societal values, what matters to us, and what influences changes over time. We discuss a theft of a Fabergé egg and the unusual means the thief used to take it.Brain Candy Podcast Website - https://thebraincandypodcast.com/Brain Candy Podcast Book Recommendations - https://thebraincandypodcast.com/books/Brain Candy Podcast Merchandise - https://thebraincandypodcast.com/candy-store/Brain Candy Podcast Candy Club - https://thebraincandypodcast.com/product/candy-club/Brain Candy Podcast Sponsor Codes - https://thebraincandypodcast.com/support-us/Brain Candy Podcast Social Media & Platforms:Brain Candy Podcast LIVE Interactive Trivia Nights - https://www.youtube.com/@BrainCandyPodcast/streamsBrain Candy Podcast Instagram: https://www.instagram.com/braincandypodcastHost Susie Meister Instagram: https://www.instagram.com/susiemeisterHost Sarah Rice Instagram: https://www.instagram.com/imsarahriceBrain Candy Podcast on X: https://www.x.com/braincandypodBrain Candy Podcast Patreon: https://www.patreon.com/braincandy (JOIN FREE - TONS OF REALITY TV CONTENT)Brain Candy Podcast Sponsors, partnerships, & Products that we love:Head to https://airdoctorpro.com and use promo code CANDY to get UP TO $300 off today!Cancel your unwanted subscriptions and reach your financial goals faster at https://rocketmoney.com/braincandy today.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today we're honored to welcome Stan Lai, one of the world's most celebrated playwrights and theatre directors. He has been called by one critic ‘the major contemporary Asian playwright of his time, perhaps of all time' and by the BBC ‘the best Chinese-language playwright and director in the world'. Stan's Website @Stanlai99 on Instagram Stan on YouTube Born in the U.S. and raised in both America and Taiwan, Stan earned his PhD from UC Berkeley before launching a groundbreaking career in Taiwan that now spans over 40 acclaimed plays, including masterpieces like A Dream Like a Dream and Secret Love in Peach Blossom Land. He's also the co-founder of the Wuzhen Theatre Festival and Huichang Theatre Village in China, and his Shanghai venue, Theatre Above, is dedicated entirely to his work.Stan joins us today to discuss his new book, CreativitRy: Asia's Iconic Playwright Reveals the Art of Creativity, coming in November 2025 from Anthem Press — a transformative guide that blends memoir, Buddhist philosophy, and practical methods for unlocking the creative potential that lives within each of us. https://a.co/d/56PRqeG5 QuestionsThe Source of CreativityStan, you've said that CreativitRy explores “where creativity lives — within each and every one of us.” How did your own creative process as a playwright and director lead you to this realization, and what inspired you to put these ideas into book form?From Stage to Page — Translating Art into InsightYour plays are known for their emotional depth and philosophical reach. How was writing about creativity — in prose rather than in performance — a different kind of creative act for you?Buddhist Wisdom and Creative FlowYou describe the book as rooted in Buddhist thought, guiding readers to unlock creativity through introspection rather than productivity hacks. How do mindfulness and spiritual awareness shape your own approach to artistic creation?Creativity as Education — A New FrontierCreativitRy is being adopted as the foundational text for a new Department of Creative Studies at major Chinese universities. How did that initiative come about, and what does it say about the growing importance of creativity in education and society today?The Universality of the Creative JourneyYou've been praised by artists like Ang Lee and Jack Ma for bridging the arts, business, and human growth. What do you hope readers — whether they're artists, entrepreneurs, or students — will take away from CreativitRy about living a truly creative life?Stan, as we close, what's one piece of advice you'd offer to someone who feels disconnected from their creativity — someone who wants to rediscover that creative energy in everyday life?Thanks to our sponsor, White Cloud Coffee — fueling creative conversations everywhere. Listeners, enjoy 10% off your first order at whitecloudcoffee.com.And be sure to download your free e-book of Your World of Creativity when you visit

Tasha Eurich shares why pushing through sometimes isn't enough–and how to bounce back stronger than ever.— YOU'LL LEARN — 1) The hidden costs of “grit gaslighting” 2) How to know when you've hit your “resilience ceiling” 3) The three needs that unlocks the best version of yourselfSubscribe or visit AwesomeAtYourJob.com/ep1066 for clickable versions of the links below. — ABOUT TASHA — Dr. Tasha Eurich is an organizational psychologist, researcher, and New York Times best-selling author (Shatterproof, Insight, Bankable Leadership). She helps people thrive in a changing world by becoming the best of who they are and what they do. With a PhD in Industrial-Organizational Psychology, Tasha is the principal of The Eurich Group, a boutique consultancy that helps successful executives succeed when the stakes are high. As an author and sought-after speaker in the self-improvement space, Tasha is a candid yet compassionate voice. Pairing her scientific grounding with 20+ years of experience on the corporate front lines, she reveals the often-surprising secrets to success and fulfillment in the 21st century. • Book: Shatterproof: How to Thrive in a World of Constant Chaos (And Why Resilience Alone Isn't Enough) • Quiz: The Resilience Ceiling Quiz • Website: TashaEurich.com— RESOURCES MENTIONED IN THE SHOW — • Book: Give and Take: Why Helping Others Drives Our Success by Adam Grant • Book: Resilient: How to Grow an Unshakable Core of Calm, Strength, and Happiness by Rick Hanson and Forrest Hanson • Book: Team of Rivals: The Political Genius of Abraham Lincoln by Doris Kearns Goodwin • Book: The Great Gatsby by F. Scott Fitzgerald • Study: Need Crafting• Website: World Uncertainty Index • Past episode: 1065: Harvard's Stress Expert Shares Top Resilience Tools with Dr. Aditi Nerurkar— THANK YOU SPONSORS! — • Vanguard. Give your clients consistent results year in and year out with vanguard.com/AUDIO• Quince. Get free shipping and 365-day returns on your order with Quince.com/Awesome• Cashflow Podcasting. Explore launching (or outsourcing) your podcast with a free 10-minute call with Pete.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Grab a copy of Dr. Ingrid Clayton's book here — https://amzn.to/48Semw4Want to listen on Audible? Get a free Premium Plus trial here: https://www.amazon.com/hz/audible/mlp(As an Amazon associate, I receive a small commission on purchases made through the links on this channel. Thanks for making this show possible!)Ingrid Clayton, PhD, is a writer and clinical psychologist in private practice in Los Angeles, California. She's the author of Fawning: a powerful to the often-overlooked piece of the fight-flight-freeze reaction to trauma, Believing Me: Healing from Narcissistic Abuse and Complex Trauma, where she uncovers her personal experience of childhood trauma from a psychologist's perspective, and Recovering Spirituality: Achieving Emotional Sobriety in Your Spiritual Practice. Ingrid is a regular contributor to Psychology Today, where her article “What is Self-Gaslighting?” is considered an essential read!With a Masters in transpersonal psychology and a PhD in clinical psychology, Ingrid has a holistic approach to psychotherapy, incorporating trauma-informed modalities like Somatic Experiencing, EMDR, and other experiential ways of working with the nervous system. Ingrid has been using a relational approach to therapy since 2004, bringing her whole self to the work—including her personal experience, intuition, and education. This enables her to be in real connection and collaboration with her clients.✖️✖️✖️Support the Show: Patreon.com/PreacherBoys✖️✖️✖️If you or someone you know has experienced abuse, visit courage365.org/need-help✖️✖️✖️CONNECT WITH THE SHOW:preacherboyspodcast.comhttps://www.youtube.com/@PreacherBoyshttps://www.facebook.com/preacherboysdoc/https://twitter.com/preacherboysdochttps://www.instagram.com/preacherboyspodhttps://www.tiktok.com/@preacherboyspodTo connect with a community that shares the Preacher Boys Podcast's mission to expose abuse in the IFB, join the OFFICIAL Preacher Boys Facebook Group: https://www.facebook.com/groups/1403898676438188/✖️✖️✖️The content presented in this video is for informational and educational purposes only. All individuals and entities discussed are presumed innocent until proven guilty through due legal process. The views and opinions expressed are those of the speakers.✖️✖️✖️Music by Lou Ridley — “Bible Belt” | Used with permission under license.This episode is sponsored by/brought to you by BetterHelp. Give online therapy a try at betterhelp.com/PreacherBoys and get on your way to being your best self.Support this podcast at — https://redcircle.com/preacher-boys-podcast/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Dr. Sonia Contera is an Associate Professor of Biological Physics at the University of Oxford Physics Department, and a Research Fellow of Green Templeton College. She is also the author of the recently released book Nano comes to Life. Sonia is a physicist who is interested in biology and the mechanics of biology across different space and time scales. She develops experiments and techniques to understand the physics that allow biological systems to build nano-scale molecules into cells, organs, tissues, and organisms. Projects in Sonia's lab include studying and treating pancreatic tumors, understanding heart arrhythmias, and investigating the physics of plant growth. When she's not doing science, Sonia likes to relax and do nothing. She also enjoys spending time with people she loves, talking to people, cycling, walking, exploring art, and learning new languages. Sonia received her bachelor's degree in physics from the Autonomous University of Madrid. She attended graduate school at Beijing Languages and Culture University and subsequently worked as a researcher at the Czech Academy of Sciences. Sonia was then awarded a Japanese Government Monbushō scholarship to attend Osaka University where she received her PhD in Applied Physics. Next, Sonia was awarded an E.U. Fellowship to Japan at the Institute of Scientific and Industrial Research SANKEN at Osaka University. Prior to coming to Oxford in 2003, she served as a Research Assistant Professor at the Interdisciplinary Nanoscience Centre at the University of Aarhus in Denmark. In 2008, Sonia founded the Oxford Martin Institute of Nanoscience for Medicine at the Oxford Martin School. In our interview, Sonia shares more about her life and science.

John Anderson speaks with James Orr to examine the deeper moral, cultural, and institutional pressures shaping Britain and the wider Western world. Drawing on political philosophy, social analysis, and recent events, Orr challenges the prevailing assumption that economic management and procedural politics can sustain a stable society. He argues that questions of identity, belonging, and shared obligation now sit at the centre of national renewal. This conversation traces the erosion of social trust, the limits of rights-based politics, and the consequences of demographic and cultural fragmentation. It is a measured discussion that reorients political debate toward the moral and cultural foundations required for long-term national stability, rather than short-term policy adjustments. Dr. Orr holds a PhD and MPhil in Philosophy of Religion from the University of Cambridge and a BA in Classics from Oxford. He is a political philosopher, writer, and commentator whose work focuses on conservatism, political theology, identity, and the cultural preconditions of liberal democracy, with particular attention to Britain's institutional and civilisational inheritance.

JonRobert Tartaglione, PhD, studies & teaches influence. He is a psychologist, behavioral scientist & the founder & CEO of a consulting practice called influence 51. In this episode, we unpack persuasion, perception & arguing on the internet and explore what it really takes to change someone's mind. If you like this episode, you'll also like episode 309: HOW DID THE MEDIA BECOME SUCH A BIASED, STRESS-INDUCING CIRCUS? Guest:https://www.facebook.com/jonrobert.tartaglione https://www.instagram.com/probablytat/ https://www.linkedin.com/in/jonrobert-tartaglione-ph-d-21b26770/https://x.com/PolPsyTat https://influence51.com/  Host:  https://www.meredithforreal.com/  https://www.instagram.com/meredithforreal/ meredith@meredithforreal.comhttps://www.youtube.com/meredithforreal  https://www.facebook.com/meredithforrealthecuriousintrovert  Sponsors: https://www.jordanharbinger.com/starterpacks/ https://www.historicpensacola.org/about-us/  00:00 — The question no one asks01:42 — Why this story matters now03:18 — Meeting JonRobert05:06 — What most people misunderstand07:02 — The moment everything shifted09:21 — How power actually works11:08 — Systems hiding in plain sight13:47 — When incentives shape behavior16:05 — Following the money18:12 — What surprised him most20:44 — The quiet pressure points23:01 — Where people lose agency25:26 — The illusion of choice27:58 — Why good people comply30:14 — This wasn't accidental32:41 — How narratives get enforced35:09 — Who benefits from silence37:42 — The cost of speaking up40:06 — When resistance becomes personal42:33 — The moment of reckoning45:02 — Why fear is effective47:29 — The psychology underneath50:11 — How normalization happens52:46 — What history keeps repeating55:21 — The warning signs we ignore58:04 — This pattern feels familiar01:00:33 — When people finally notice01:03:07 — Why it feels overwhelming01:05:52 — Reclaiming critical thinking01:08:36 — What accountability would look like01:11:14 — The role of individual courage01:14:02 — Why hope isn't naive01:16:41 — What comes next01:19:08 — The question listeners should sit with01:21:30 — Final reflectionsRequest to join my private Facebook Group, MFR Curious Insiders https://www.facebook.com/share/g/1BAt3bpwJC/

After 450 episodes, the podcast takes a new direction as host Dr. Debi shares the deeply personal story behind the Post Betrayal Transformation® (PBT®) Certification Program—the only research-based program for healing from betrayal using the Five Stages from Betrayal to Breakthrough.  What You'll Learn  The Personal Journey  How childhood betrayal and later spousal betrayal led to a transformative healing journey  The decision to pursue a PhD in Transpersonal Psychology while barely functioning  Discovering the Five Stages of Betrayal Recovery through rigorous research and personal implementation  The vulnerable choice to share this private story to help others heal  The Research Behind PBT  Why there was no deep-dive study on the lived experience of betrayal  How the "Fab 14" women contributed to groundbreaking research  The moment a study chair recognized a documented process in the findings  Moving from theory to proven methodology through personal experience  Physical and Emotional Healing  Understanding Post Betrayal Syndrome®  symptoms and their impact  How healing affects sleep, immune system, weight, and overall wellbeing  Why traditional therapy often keeps people stuck in the same patterns  The difference between staying in Stage 3 (quicksand) versus moving to Stages 4 and 5  The Certification Program  Why teaching coaches and practitioners creates exponential healing  How the certification includes personal healing work before teaching others  Real transformations: new businesses, restored health, rebuilt relationships  The vision of reaching thousands through trained practitioners rather than one-on-one work  Impact on Different Professions  Life Coaches: Helping clients who can't focus or move forward  Business Coaches: Supporting entrepreneurs who can't sell or promote themselves  Health Coaches: Understanding why clients sabotage healthy protocols  Leadership Coaches: Addressing trust issues that lead to micromanaging  Parents: Becoming role models of resilience for their children  Key Takeaways  Betrayal is uniquely traumatic—it shatters trust and creates physical symptoms  Healing is possible through a structured, research-based approach  The Five Stages can shorten decades of pain into a manageable healing journey  Transformation creates access to a version of yourself you didn't have before  Sharing your story, despite vulnerability, can create mass healing  Memorable Quotes  "Get out of the way. Your ego and pride are preventing people from healing."  "This work can shorten someone's pain by decades."  "Stage 3 is quicksand—it's where most people get stuck."  "Nothing was as painful for me as betrayal, and nothing feels better than transforming from it."  Resources Mentioned  PBT®  (Post Betrayal Transformation®) Certification Program  The PBT®  Institute  Previous TEDx talks: "Stop Sabotaging Yourself" and "Do You Have Post Betrayal Syndrome?"  Book: Trust Again  About Post Betrayal Syndrome®  Post Betrayal Syndrome includes symptoms such as:  Sleep disruption and fatigue  Weakened immune system  Weight gain (especially around midsection)  Inability to focus or concentrate  Emotional overwhelm and triggers  Who This Episode Is For  Anyone who has experienced betrayal (family, partner, friend, coworker)  Coaches, therapists, counselors, and practitioners wanting to help betrayal survivors  Health and wellness professionals whose clients are stuck or self-sabotaging  Anyone interested in trauma recovery and transformation  People seeking to turn their pain into purpose  Next Steps  If you're interested in the PBT®  Certification Program or want to learn more about the Five Stages from Betrayal to Breakthrough, visit the PBT®  Institute or reach out with questions and comments. 

This week we're introducing you to Pulling the Thread, hosted by writer Elise Loehnen, who explores life's big questions with today's leading thinking, experts and luminaries: Why do we do what we do? How can we understand and love ourselves better? What would it look like to come together and build a more meaningful world? In today's episode we're joined by James Hollis, PhD is a Jungian analyst who is still in private practice in Washington D.C. Hollis started his career as a professor of humanities before a midlife crisis brought him to his knees—and to the Jung Institute in Zurich. The author of 19 books, Hollis is one of the best interpreters of Carl Jung’s work, making it accessible for all of us who want to understand how complexes, archetypes, synchronicities, and the shadow drive our lives. To hear more episode of Pulling the Thread, follow wherever you get your podcasts or head to: https://lemonada.lnk.to/PullingTheThreadfd MORE FROM JAMES HOLLIS, PhD: Why Good People Do Bad Things: Understanding Our Darker Selves Finding Meaning in the Second Half of Life: How to Finally, Really Grow Up A Life of Meaning: Relocating Your Center of Spiritual Gravity The Broken Mirror: Refracted Visions of Ourselves James Hollis’s Website RELATED EPISODES: Connie Zweig, “Embracing the Shadow” Satya Doyle Byock, “Navigating Quarterlife” Terry Real, “Healing Male Depression” Niobe Way, PhD, “The Critical Need for Deep Connection” See omnystudio.com/listener for privacy information.

This week we're introducing you to Pulling the Thread, hosted by writer Elise Loehnen, who explores life's big questions with today's leading thinking, experts and luminaries: Why do we do what we do? How can we understand and love ourselves better? What would it look like to come together and build a more meaningful world? In today's episode we're joined by James Hollis, PhD is a Jungian analyst who is still in private practice in Washington D.C. Hollis started his career as a professor of humanities before a midlife crisis brought him to his knees—and to the Jung Institute in Zurich. The author of 19 books, Hollis is one of the best interpreters of Carl Jung’s work, making it accessible for all of us who want to understand how complexes, archetypes, synchronicities, and the shadow drive our lives. To hear more episode of Pulling the Thread, follow wherever you get your podcasts or head to: https://lemonada.lnk.to/PullingTheThreadfd MORE FROM JAMES HOLLIS, PhD: Why Good People Do Bad Things: Understanding Our Darker Selves Finding Meaning in the Second Half of Life: How to Finally, Really Grow Up A Life of Meaning: Relocating Your Center of Spiritual Gravity The Broken Mirror: Refracted Visions of Ourselves James Hollis’s Website RELATED EPISODES: Connie Zweig, “Embracing the Shadow” Satya Doyle Byock, “Navigating Quarterlife” Terry Real, “Healing Male Depression” Niobe Way, PhD, “The Critical Need for Deep Connection” See omnystudio.com/listener for privacy information.

This week we're introducing you to Pulling the Thread, hosted by writer Elise Loehnen, who explores life's big questions with today's leading thinking, experts and luminaries: Why do we do what we do? How can we understand and love ourselves better? What would it look like to come together and build a more meaningful world? In today's episode we're joined by James Hollis, PhD is a Jungian analyst who is still in private practice in Washington D.C. Hollis started his career as a professor of humanities before a midlife crisis brought him to his knees—and to the Jung Institute in Zurich. The author of 19 books, Hollis is one of the best interpreters of Carl Jung’s work, making it accessible for all of us who want to understand how complexes, archetypes, synchronicities, and the shadow drive our lives. To hear more episode of Pulling the Thread, follow wherever you get your podcasts or head to: https://lemonada.lnk.to/PullingTheThreadfd MORE FROM JAMES HOLLIS, PhD: Why Good People Do Bad Things: Understanding Our Darker Selves Finding Meaning in the Second Half of Life: How to Finally, Really Grow Up A Life of Meaning: Relocating Your Center of Spiritual Gravity The Broken Mirror: Refracted Visions of Ourselves James Hollis’s Website RELATED EPISODES: Connie Zweig, “Embracing the Shadow” Satya Doyle Byock, “Navigating Quarterlife” Terry Real, “Healing Male Depression” Niobe Way, PhD, “The Critical Need for Deep Connection” See omnystudio.com/listener for privacy information.

This week we're introducing you to Pulling the Thread, hosted by writer Elise Loehnen, who explores life's big questions with today's leading thinking, experts and luminaries: Why do we do what we do? How can we understand and love ourselves better? What would it look like to come together and build a more meaningful world? In today's episode we're joined by James Hollis, PhD is a Jungian analyst who is still in private practice in Washington D.C. Hollis started his career as a professor of humanities before a midlife crisis brought him to his knees—and to the Jung Institute in Zurich. The author of 19 books, Hollis is one of the best interpreters of Carl Jung’s work, making it accessible for all of us who want to understand how complexes, archetypes, synchronicities, and the shadow drive our lives. To hear more episode of Pulling the Thread, follow wherever you get your podcasts or head to: https://lemonada.lnk.to/PullingTheThreadfd MORE FROM JAMES HOLLIS, PhD: Why Good People Do Bad Things: Understanding Our Darker Selves Finding Meaning in the Second Half of Life: How to Finally, Really Grow Up A Life of Meaning: Relocating Your Center of Spiritual Gravity The Broken Mirror: Refracted Visions of Ourselves James Hollis’s Website RELATED EPISODES: Connie Zweig, “Embracing the Shadow” Satya Doyle Byock, “Navigating Quarterlife” Terry Real, “Healing Male Depression” Niobe Way, PhD, “The Critical Need for Deep Connection”See omnystudio.com/listener for privacy information.

This week we're introducing you to Pulling the Thread, hosted by writer Elise Loehnen, who explores life's big questions with today's leading thinking, experts and luminaries: Why do we do what we do? How can we understand and love ourselves better? What would it look like to come together and build a more meaningful world? In today's episode we're joined by James Hollis, PhD is a Jungian analyst who is still in private practice in Washington D.C. Hollis started his career as a professor of humanities before a midlife crisis brought him to his knees—and to the Jung Institute in Zurich. The author of 19 books, Hollis is one of the best interpreters of Carl Jung’s work, making it accessible for all of us who want to understand how complexes, archetypes, synchronicities, and the shadow drive our lives. To hear more episode of Pulling the Thread, follow wherever you get your podcasts or head to: https://lemonada.lnk.to/PullingTheThreadfd MORE FROM JAMES HOLLIS, PhD: Why Good People Do Bad Things: Understanding Our Darker Selves Finding Meaning in the Second Half of Life: How to Finally, Really Grow Up A Life of Meaning: Relocating Your Center of Spiritual Gravity The Broken Mirror: Refracted Visions of Ourselves James Hollis’s Website RELATED EPISODES: Connie Zweig, “Embracing the Shadow” Satya Doyle Byock, “Navigating Quarterlife” Terry Real, “Healing Male Depression” Niobe Way, PhD, “The Critical Need for Deep Connection” See omnystudio.com/listener for privacy information.

This week we're introducing you to Pulling the Thread, hosted by writer Elise Loehnen, who explores life's big questions with today's leading thinking, experts and luminaries: Why do we do what we do? How can we understand and love ourselves better? What would it look like to come together and build a more meaningful world? In today's episode we're joined by James Hollis, PhD is a Jungian analyst who is still in private practice in Washington D.C. Hollis started his career as a professor of humanities before a midlife crisis brought him to his knees—and to the Jung Institute in Zurich. The author of 19 books, Hollis is one of the best interpreters of Carl Jung’s work, making it accessible for all of us who want to understand how complexes, archetypes, synchronicities, and the shadow drive our lives. To hear more episode of Pulling the Thread, follow wherever you get your podcasts or head to: https://lemonada.lnk.to/PullingTheThreadfd MORE FROM JAMES HOLLIS, PhD: Why Good People Do Bad Things: Understanding Our Darker Selves Finding Meaning in the Second Half of Life: How to Finally, Really Grow Up A Life of Meaning: Relocating Your Center of Spiritual Gravity The Broken Mirror: Refracted Visions of Ourselves James Hollis’s Website RELATED EPISODES: Connie Zweig, “Embracing the Shadow” Satya Doyle Byock, “Navigating Quarterlife” Terry Real, “Healing Male Depression” Niobe Way, PhD, “The Critical Need for Deep Connection”See omnystudio.com/listener for privacy information.

This week we're introducing you to Pulling the Thread, hosted by writer Elise Loehnen, who explores life's big questions with today's leading thinking, experts and luminaries: Why do we do what we do? How can we understand and love ourselves better? What would it look like to come together and build a more meaningful world? In today's episode we're joined by James Hollis, PhD is a Jungian analyst who is still in private practice in Washington D.C. Hollis started his career as a professor of humanities before a midlife crisis brought him to his knees—and to the Jung Institute in Zurich. The author of 19 books, Hollis is one of the best interpreters of Carl Jung’s work, making it accessible for all of us who want to understand how complexes, archetypes, synchronicities, and the shadow drive our lives. To hear more episode of Pulling the Thread, follow wherever you get your podcasts or head to: https://lemonada.lnk.to/PullingTheThreadfd MORE FROM JAMES HOLLIS, PhD: Why Good People Do Bad Things: Understanding Our Darker Selves Finding Meaning in the Second Half of Life: How to Finally, Really Grow Up A Life of Meaning: Relocating Your Center of Spiritual Gravity The Broken Mirror: Refracted Visions of Ourselves James Hollis’s Website RELATED EPISODES: Connie Zweig, “Embracing the Shadow” Satya Doyle Byock, “Navigating Quarterlife” Terry Real, “Healing Male Depression” Niobe Way, PhD, “The Critical Need for Deep Connection”See omnystudio.com/listener for privacy information.

This week we're introducing you to Pulling the Thread, hosted by writer Elise Loehnen, who explores life's big questions with today's leading thinking, experts and luminaries: Why do we do what we do? How can we understand and love ourselves better? What would it look like to come together and build a more meaningful world? In today's episode we're joined by James Hollis, PhD is a Jungian analyst who is still in private practice in Washington D.C. Hollis started his career as a professor of humanities before a midlife crisis brought him to his knees—and to the Jung Institute in Zurich. The author of 19 books, Hollis is one of the best interpreters of Carl Jung’s work, making it accessible for all of us who want to understand how complexes, archetypes, synchronicities, and the shadow drive our lives.To hear more episode of Pulling the Thread, follow wherever you get your podcasts or head to: https://lemonada.lnk.to/PullingTheThreadfd MORE FROM JAMES HOLLIS, PhD: Why Good People Do Bad Things: Understanding Our Darker Selves Finding Meaning in the Second Half of Life: How to Finally, Really Grow Up A Life of Meaning: Relocating Your Center of Spiritual Gravity The Broken Mirror: Refracted Visions of Ourselves James Hollis’s Website RELATED EPISODES: Connie Zweig, “Embracing the Shadow” Satya Doyle Byock, “Navigating Quarterlife” Terry Real, “Healing Male Depression” Niobe Way, PhD, “The Critical Need for Deep Connection” Learn more about your ad choices. Visit podcastchoices.com/adchoicesSee omnystudio.com/listener for privacy information.

This week we're introducing you to Pulling the Thread, hosted by writer Elise Loehnen, who explores life's big questions with today's leading thinking, experts and luminaries: Why do we do what we do? How can we understand and love ourselves better? What would it look like to come together and build a more meaningful world? In today's episode we're joined by James Hollis, PhD is a Jungian analyst who is still in private practice in Washington D.C. Hollis started his career as a professor of humanities before a midlife crisis brought him to his knees—and to the Jung Institute in Zurich. The author of 19 books, Hollis is one of the best interpreters of Carl Jung’s work, making it accessible for all of us who want to understand how complexes, archetypes, synchronicities, and the shadow drive our lives.To hear more episode of Pulling the Thread, follow wherever you get your podcasts or head to: https://lemonada.lnk.to/PullingTheThreadfd MORE FROM JAMES HOLLIS, PhD: Why Good People Do Bad Things: Understanding Our Darker Selves Finding Meaning in the Second Half of Life: How to Finally, Really Grow Up A Life of Meaning: Relocating Your Center of Spiritual Gravity The Broken Mirror: Refracted Visions of Ourselves James Hollis’s Website RELATED EPISODES: Connie Zweig, “Embracing the Shadow” Satya Doyle Byock, “Navigating Quarterlife” Terry Real, “Healing Male Depression” Niobe Way, PhD, “The Critical Need for Deep Connection” See omnystudio.com/listener for privacy information.

Send us a textMetabolic effects of soybean oil and linoleic acid on obesity, fatty liver, and liver function.Topics Discussed:Historical trends in soybean oil use: Consumption increased dramatically since the 1960s due to farming subsidies, now providing over 10% of calories for many Americans, far exceeding the 1-2% required biologically.Soybean oil's effects in mice: Diets with 8-10% linoleic acid cause obesity, fatty liver, and diabetes over weeks, unlike coconut oil diets; effects persist even after diet switch unless combined with fasting.Role of HNF4 protein: This conserved liver transcription factor binds linoleic acid, regulating gene expression for metabolism; variants shift between carbohydrate and fat processing, with imbalances linked to fatty liver and cancer.Oxylipins from linoleic acid: Conversion in liver drives obesity; mice unable to produce them resist weight gain on soybean oil, suggesting these metabolites are key culprits.Vitamin B1 & soybean oil: Diets deplete B1 in liver and blood, contributing to obesity; supplementation with B1 analogs prevents weight gain, unlike beef tallow diets which preserve B1 levels.Gut & microbiome impacts: Soybean oil alters gut bacteria, potentially reducing B1 production and increasing permeability, leading to inflammation; farm animals fed soybean meal pass effects to consumers.Broader health implications: Reanalysis of old human studies questions linoleic acid's heart benefits; focus on reducing processed foods and seed oils, while noting olive oil's advantages from historical contexts.Practical Takeaways:Limit processed foods and seed oils like soybean to reduce linoleic acid intake, aiming for 1-2% of calories; read labels and opt for olive oil or home-cooked meals.Incorporate intermittent fasting, such as 12-16 hours without eating daily, to help reverse obesity effects from high-linoleic diets, based on mouse reversibility studies.Choose grass-fed or naturally fed animal products to avoid indirect soybean oil exposure from feed, potentially preserving nutrient levels like vitamin B1.Monitor diet when traveling or changing habits, as shifts in oil types can affect medication metabolism via liver enzymes.About the guest: Frances Sladek, PhD is a professor whose research focuses on the nuclear receptor HNF4 and the health impacts of dietary fats, particularly soybean oil.*Not medical advice.Support the showAffiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

This week we're introducing you to Pulling the Thread, hosted by writer Elise Loehnen, who explores life's big questions with today's leading thinking, experts and luminaries: Why do we do what we do? How can we understand and love ourselves better? What would it look like to come together and build a more meaningful world? In today's episode we're joined by James Hollis, PhD is a Jungian analyst who is still in private practice in Washington D.C. Hollis started his career as a professor of humanities before a midlife crisis brought him to his knees—and to the Jung Institute in Zurich. The author of 19 books, Hollis is one of the best interpreters of Carl Jung’s work, making it accessible for all of us who want to understand how complexes, archetypes, synchronicities, and the shadow drive our lives. To hear more episode of Pulling the Thread, follow wherever you get your podcasts or head to: https://lemonada.lnk.to/PullingTheThreadfd MORE FROM JAMES HOLLIS, PhD: Why Good People Do Bad Things: Understanding Our Darker Selves Finding Meaning in the Second Half of Life: How to Finally, Really Grow Up A Life of Meaning: Relocating Your Center of Spiritual Gravity The Broken Mirror: Refracted Visions of Ourselves James Hollis’s Website RELATED EPISODES: Connie Zweig, “Embracing the Shadow” Satya Doyle Byock, “Navigating Quarterlife” Terry Real, “Healing Male Depression” Niobe Way, PhD, “The Critical Need for Deep Connection”See omnystudio.com/listener for privacy information.

¿Qué tangos se escuchaban en Medellín antes de la muerte de Gardel? ¿De qué manera fue usado el bambuco como defensa conservadora de la blancura en los años 50 frente a la música tropical costeña? ¿Qué papel jugaron las emisoras locales de Medellín en la guerra de las textileras Coltejer y Fabricato? ¿Cómo suena la MEMORIA de una ciudad? La etnomusicóloga Carolina Santamaría Delgado nos cuenta sobre su investigación sobre la escucha y la música popular en Medellín a mediados del siglo XX y sobre cómo los sonidos configuraron la identidad cultural de la región. En Medellín se cruzaron ritmos del Caribe, México, Argentina y Estados Unidos. La ciudad se convirtió en un centro de la industria cultural colombiana a partir de los años 50, con el surgimiento de grandes conglomerados como RCN y Caracol. Santamaría aborda la tensión entre las visiones de músicos bogotanos como Emilio Murillo, defensor de la música como emblema nacional, y antioqueños como Gonzalo Vidal, quien priorizaba la formación académica europea. La investigadora cuestiona el mito de que la muerte de Gardel convirtió a Medellín en ciudad tanguera, señalando que ya existía una CULTURA DE ESCUCHA arraigada en mercados y espacios populares como Guayaquil antes de 1935. “La escucha no es necesariamente una cosa pasiva. Al momento de escuchar también hay una acción, hay un hacer”. CAROLINA SANTAMARÍA DELGADO Maestra en Música de la Pontificia Universidad Javeriana, MA y PhD en Etnomusicología de la Universidad de Pittsburgh. Es formada en estudios culturales y estudios latinoamericanos. Desde el 2003 colabora frecuentemente con el sello discográfico académico Smithsonian Folkways Recordings. Ha sido Tinker visiting professor en el Teresa Lozano Long Institute of Latin American Studies en la Universidad de Texas.

Nicola Longo MD, PhD, and Mark Roberts, MDNicola Longo MD, PhDProfessor and Vice Chair of Human Genetics,Allen and Charlotte Ginsburg Chair in Precision Genomic Medicine,Division of Clinical Genetics, Department of Human Genetics,University of California at Los Angeles (UCLA), Los Angeles, CA, USAMark Roberts, MDProfessor and Consultant Neurologist,University of Manchester, Manchester, UKResearch Lead for Adult Metabolic Medicine at Salford Care Organisation, Manchester, UKDrs.Longo and Roberts discussed the current status of gene therapies in rare neuromuscular disorders in this eight-part podcast series. This is derived from the symposium that was presented at World Symposium 2025 in San Diego, California on February 4th through 7th, 2025 and is intended for healthcare professionals only.This podcast includes information about investigational compounds that do not yet have a regulatory approval or authorization for a specific indication. The safety and efficacy of the agents under investigation have not been established and contents of this podcast shall not be used in any manner to directly or indirectly promote or sell the product for unapproved uses. The views, thoughts, and opinions expressed in this presentation belong solely to the author and are subject to change without notice. The contents of this presentation do not constitute an endorsement of any product or indication by Astellas.In this part, Dr. Roberts will discuss lessons learned from gene therapy trials.Mark Roberts, MDWhen we think about the challenges of actually doing clinical trials with these gene therapies, there's a huge development stage in terms of picking the right viral vector with the right surface receptor. That's a major piece of work. That can often take years. The preclinical work is obviously very important as indeed is understanding the natural history because it's really not practical to do placebo-controlled trials of gene therapies.In contrast to other studies, when we turn to phase 1 and phase 2, you'll notice that the patient numbers are often quite small. One is having to think carefully about surrogate measurements of response. Especially when in phase 3 studies, we may be thinking about withdrawing the existing, for example, enzyme replacement therapy because we believe the gene therapy will then be effective.That's just a few snapshots of where we've come and there's a lot more work to be done.In the next part, Dr. Longo will discuss the current treatment landscape and limitations in lysosomal disorders.

Nicola Longo MD, PhD, and Mark Roberts, MD Nicola Longo MD, PhDProfessor and Vice Chair of Human Genetics,Allen and Charlotte Ginsburg Chair in Precision Genomic Medicine,Division of Clinical Genetics, Department of Human Genetics,University of California at Los Angeles (UCLA), Los Angeles, CA, USAMark Roberts, MDProfesor and Consultant Neurologist,University of Manchester, Manchester, UKResearch Lead for Adult Metabolic Medicine at Salford Care Organisation, Manchester, UKDrs. Longo and Roberts discuss the current status of gene therapies in rare neuromuscular disorders in this eight-part podcast series. This is derived from the symposium that was presented at World Symposium 2025 in San Diego, California on February 4th through 7th, 2025 and is intended for healthcare professionals only. This podcast includes information about investigational compounds that do not yet have a regulatory approval or authorization for a specific indication. The safety and efficacy of the agents under investigation have not been established and contents of this podcast shall not be used in any manner to directly or indirectly promote or sell the product for unapproved uses. The views, thoughts, and opinions expressed in this presentation belong solely to the author and are subject to change without notice.The contents of this presentation do not constitute an endorsement of any product or indication by Astellas. In this part, Dr. Roberts will discuss vectors, different strategies, modes of administration and targets in gene replacement therapies.Mark Roberts, MDNow in the broader sense, gene replacement therapy seeks to actually deliver genetic material directly into the host cell to influence gene expression. In the most simple idea, one of course has a vector, this is most commonly but not exclusively a virus, which can then be given intravenously for example, and can hope to potentially correct the condition within the individual cells using novel transgenes. Suitable candidate conditions for this as examples of genetic conditions are now well understood. And crucially, this applies not only towards some more recessive, but dominant and even accident conditions.Across the piece, one can see for example, mitochondrial problems, spinal muscular atrophy as is well known, X-linked myotubular myopathy, Duchenne muscular dystrophy, a very common condition affecting one in 3000 male individuals, Pompe disease of course, an important focus of the meeting here, but other very common conditions, for example, cystic fibrosis, immunological conditions and perhaps obviously very crucial in early work on gene therapy, hemophilia.Let's now think about the approaches to gene therapy. One can seek to work at the DNA level and gene replacement. In essence, one is trying to put a new transgene through into the nucleus that will ultimately be transcribed and translated and produce the important functional protein that is lost. Gene editing which is a very exciting new technology or CRISPR technology actually seeks to actually modify in vivo the actual mutations that are responsible for the pathogenic production of abnormal proteins and correcting these and actually producing a more normalized protein.But of course there are also RNA approaches where one seeks to actually repair the mRNA transcripts copied from the mutated gene. For example, this may be a novel approach that could be extremely useful in myotonic dystrophy, a multisystem condition. When we talk about the viral vectors, predominantly we're talking about viruses. Those such as adenoviruses and AAV viruses which have the virtue of not integrating into the host genome or at least not in a large amount, and those which deliberately seek to integrate into host genome such as retroviral or lentiviral systems that may be particularly useful for ex vivo systems.There are of course other ways to get genetic payloads into the nucleus, various polymers, nanoparticles and even cell penetrating peptides. Nanoparticles in particular is certainly on the ascendant. That being said, in a recent review of the clinical trials in gene therapy, it was certainly the viral vectors that stood out both in direct gene replacement with lentivirus and AAV, but also actually as delivery systems, for example, for gene editing. An example of what one is seeking to do with AAV, so of course one seeking to remove the native DNA, insert the new transgene directly into the vector and of course keen to make sure that there's a high transmission into the capsid producing a recombinant AAV, which then can be given as a treatment and hopefully produce a therapeutic increase in the functional protein that is deficit in the disorder.In the next part, Dr. Roberts will discuss immune responses and other safety concerns related to gene therapies.

Nicola Longo MD, PhD, and Mark Roberts, MDNicola Longo MD, PhDProfessor and Vice Chair of Human Genetics,Allen and Charlotte Ginsburg Chair in Precision Genomic Medicine,Division of Clinical Genetics, Department of Human Genetics,University of California at Los Angeles (UCLA), Los Angeles, CA, USAMark Roberts, MDProfesor and Consultant Neurologist,University of Manchester, Manchester, UKResearch Lead for Adult Metabolic Medicine at Salford Care Organisation, Manchester, UKDrs. Longo and Roberts discuss the current status of gene therapies in rare neuromuscular disorders in this 8-part podcast series. This is derived from the symposium that was presented at World Symposium 2025 in San Diego, California on February 4th-7th 2025 and is intended for healthcare professionals only.This podcast includes information about investigational compounds that do not yet have a regulatory approval or authorization for a specific indication. The safety and efficacy of the agents under investigation have not been established and contents of this podcast shall not be used in any manner to directly or indirectly promote or sell the product for unapproved uses.The views, thoughts, and opinions expressed in this presentation belong solely to the author and are subject to change without notice. The contents of this presentation do not constitute an endorsement of any product or indication by Astellas. In this part, Dr. Roberts will discuss immune responses and other safety concerns related to gene therapies.Mark Roberts, MDUndoubtedly, the immune system is a major issue in these patients. It would be fantastic if we could immunotolerize our patients and indeed prevent the rejection of the therapy. We've talked about the fact that these are viral vectors and of course there may be high seroprevalence of antibodies to these viral vectors, and it's very important in the pre-screening of patients who might be eligible to understand that at the beginning. These of course can have developed over the years and of course can be part of immunological memory and therefore extremely difficult and probably impractical to actually shift.On giving the treatment though as I think we're all aware there is this problem of the innate immunity and potential therefore for acute toxicities and then a learned or adaptive response with cytotoxic T cells and antibodies which may of course become high tighter neutralizing antibodies and potentially antibodies not only against the viral vector, even the functional protein, even the transgene are all theoretical possibilities with time. The capsid, the transgene, and even the protein product can all potentially induce an immunological event. Of course, all of these would lead to both potential patient changes and then a lack of efficacy of the treatment.Indeed, there have been some serious and indeed fatal problems in the gene therapy development program as I think we're all aware. Though many of these are thankfully been overcome. Spinal muscular atrophy has a gene therapy which is licensed, but there were early patients who actually had significant problems. A patient of just 6 months of age who developed kidney failure, two other patients who actually developed liver failure.In Duchenne muscular dystrophy, a very common condition, again there were significant issues and crucially in these patients who all have cardiomyopathy, it was heart failure and cardiac arrest that were big concerns and pulmonary edema and this was seen even with a CRISPR-based technology and is perhaps is best known but has been addressed the excellent myotubular myopathy patients, four patients died and crucially quite a long time after the gene therapy emphasizing the need to monitor these patients extremely carefully and these patients died of cholestatic liver failure albeit that they had a degree of liver dysfunction.That's changed our screening of course of patients, we're now all looking in myotubular patients for liver involvement and Rett syndrome as well. Now these immunoprophylaxis treatment regimes to hopefully try and reduce the immunological reaction against the gene are certainly evolving.This is just a summary of some of the other immunosuppressive regimes used in other disorders, for example, spinal muscular atrophy, but Pompe and MPS as examples of LSDs. Certainly these regimes will continue to evolve and are going to be very important in seeking to make sure that these treatments are effective. It reminds me somewhat of what's happened with enzyme replacement therapy that the use of these immunological strategies in infants has revolutionized the utility of those treatments in early patients.In the next part, Dr. Roberts will discuss lessons learned from gene therapy trials.

Nicola Longo MD, PhD, and Mark Roberts, MDDrs. Longo and Roberts discussed the current status of gene therapies in rare neuromuscular disorders in this eight-part podcast series. This is derived from the symposium that was presented at World Symposium 2025 in San Diego, California on February 4th through 7th, 2025, and is intended for healthcare professionals only.This podcast includes information about investigational compounds that do not yet have a regulatory approval or authorization for a specific indication. The safety and efficacy of the agents under investigation have not been established and contents of this podcast shall not be used in any manner to directly or indirectly promote or sell the product for unapproved uses. The views, thoughts, and opinions expressed in this presentation belong solely to the author and are subject to change without notice. The contents of this presentation do not constitute an endorsement of any product or indication by Astellas.In this part, Doctors Roberts and Longo will discuss treatment with gene therapies.Question: Can one administer AAV-mediated gene therapy repeatedly?Mark Roberts, MDI think the traditional view would have been no. One can think of gene therapy as a silver bullet. Hopefully, it will reach its target. But if it's not effective, that bullet has been shot, the immunological response has occurred, and it means redosing, at least with that particular vector, may become difficult. But this situation is changing and evolving as we have better understanding of immunological modulation for repeat testing. We were discussing this yesterday evening, weren't we, Professor Longo?Nicola Longo MD, PhDCorrect. Basically, the current AAV-based gene therapy cannot be readministered. It is either effective, or it doesn't work. The other thing is that even though in theory, one could utilize a different AAV vector with different immunogenicity, there is many times cross-reactivity among the different adenovirus, adeno-associated viruses. Now, there are approaches in animal models in which you give a strong immune suppression to prevent the creation of the immune response against the adeno-associated virus, and at least in the animal model, it has been possible to give some of the gene therapy repeatedly.The second approach that is being tested is with gene correction therapy, in which by using an RNA guide and the CRISPR/Cas9 system delivered by lipid nanoparticles, you basically correct some of the effective genetic information. Obviously, since this is done by lipid nanoparticles and not by an AAV, the immunity that you create is really not there. You can give this one repeatedly, and in theory, it can be given more than one time. But again, you are absolutely correct. The current gene therapy cannot be given twice, and either it works or it doesn't work.Question:vWill gene-therapy-treated patients be able to go back to the standard of care or enzyme replacement therapy?Mark Roberts, MDI think when we're talking to patients about the potential benefits of gene therapy and the amelioration of the requirement to have these infusions on a regular basis of ERT, the hope is that will work, but they need to be reassured that we can potentially go back to the ERT. Gene therapy is an important treatment, but we don't know the destination of the patient at the beginning, and we have to make it available to them to go back to ERT.One of the crucial questions, of course, though, is the basis of the immunological reaction that perhaps prevented the gene therapy being effective. If it's against the viral vector, well, okay. If it's against the transgene, not great. If it's against the functional protein, that becomes more difficult. It is somewhat, I think at this time, to be fair to say to patients, think of gene therapy as a trial treatment. It is somewhat a leap of faith and an important observation, of course, for the patient community, but just be aware there may be downsides.Nicola Longo MD, PhDThey totally agree with Dr. Roberts. In general, they should be able to go back to enzyme replacement therapy if the gene therapy is not effective. However, what we are starting to appreciate is that we need to understand the immune response, not just to the enzyme replacement therapy, but also to gene therapy. What this field is doing is forcing geneticists to deal with the immune response. I feel that historically has not been dealt together. The two things need to be integrated. The advantage of the gene therapy is that the protein is produced endogenously. There should be the development of some degree of tolerance with time in the body towards the endogenous continuous production of a protein.Now, will that happen all the time? I still do not know. Again, we need to understand much better what is the integration of the immune system with the response to gene therapy in the ongoing clinical trials.

Nicola Longo MD, PhD, and Mark Roberts, MDDrs. Longo and Roberts discuss the current status of gene therapies in rare neuromuscular disorders in this eight-part podcast series. This is derived from the symposium that was presented at WORLDSymposium 2025 in San Diego, California on February 4th-7th 2025 and is intended for healthcare professionals only.This podcast includes information about investigational compounds that do not yet have a regulatory approval or authorization for a specific indication. The safety and efficacy of the agents under investigation have not been established and contents of this podcast shall not be used in any manner to directly or indirectly promote or sell the product for unapproved uses.The views, thoughts, and opinions expressed in this presentation belong solely to the author and are subject to change without notice. The contents of this presentation do not constitute an endorsement of any product or indication by Astellas. In this part, Dr. Longo will discuss the current treatment landscape and limitations in lysosomal disorders.Nicola Longo MD, PhDWhat I want to do today, is just place gene replacement therapy within the current landscape of lysosomal storage disorder treatment therapy. Gene therapy obviously has the potential of treating lysosomal disorder to correct the root cause of lysosomal storage disorder. The gene is defective, and what happen is that you can potentially either fix the gene or bypass the lack of the genetic product. But there are already therapies that are existing and are functioning. Obviously, in many cases, the lysosomal disorder is caused by defective production of an enzyme, which is defective.We can either replace the enzyme with enzyme replacement therapy, or provide chaperone for specific mutations that retain the synthesis of the enzyme, that however is not very functional. Another avenue that it is being reported is the utilization of substrate reduction therapy. A substrate accumulates, you prevent the synthesis of the substrate to reduce the accumulation of toxic material. What we know now is that this is not enough to produce many lysosomal disorders. In many cases, the lysosomal disorder result sometime in impairment of intracellular trafficking, and sometime in the function of other organelles.At the end, it results in the activation of the macrophagic system and inflammation. Already we have some therapy acting at this level. The end result of lysosomal storage disorder, there will be cell suffering and cell death, leading to a progression of the disease, and morbidity and mortality. Now, what therapy do we have available already? Obviously, hematopoietic stem cell transplantation has been around for quite some time.It has been the same thing that we do with gene therapy, except that instead of reintroducing the gene of the subject, we place gene of a subject who is not affected of the disease. This therapy has been proven effective in cases of MPS-1 and alpha-mannosidosis. But in many cases this has to be given way before symptoms start to be affected.Enzyme replacement therapy has been around for quite some time, starting with Gaucher disease, and now that it is available for a list of diseases that are there, so it's like Fabry, Gaucher, Pompe, different types of mucopolysaccharidosis, alpha-mannosidosis, acid lipase deficiency, 1 neuronal ceroid lipofuscinosis, and Niemann-Pick type A and B.Obviously the advantage of this therapy, they give back the enzyme that it is defective. But the disadvantage that many time they cannot enter specialized areas such as the brain. There is already the second generation of enzyme replacement therapy that it is available. With this second generation, some of the newer drugs are more effective in terms of cellular uptake, or in terms of having a prolonged half-life and prolonged activity.Then there are pharmacological chaperone therapy, and the one which is FDA approved is migalastat for Fabry disease, under study is ambroxol for Gaucher disease. The disadvantage of this therapy that only a selected number of mutations respond to this therapy.Substrate reduction therapy has been introduced for Gaucher disease many years ago with miglustat, and it was followed by eliglustat. Both of them are effective, and some of them more effective than other, simply because of the fewer side effects of eliglustat as compared to miglustat. But at the same time, eliglustat does not pass the blood brain barrier.Finally, the newer agents that are already administered, N-acetyl-L-leucine and arimoclomol, both approved for Niemann-Pick type C, they act more on the downstream effect of the lysosomal storage disorder, either by stabilizing neuronal cell activity or by reducing the inflammation that is present in the brain.In the next part, Dr. Longo will discuss gene replacement therapy in lysosomal disorders.

Higher education is about transformation: research shows that the most well-prepared graduates are those who have experienced changes in how they think about and experience the world around them. Combined with flexible information-seeking and evaluation skills, learning ways to break information bubbles is essential for dealing with today's challenging, complex information environment. Jack Mezirow's transformative learning theory, which frames how adults think about and interact with the world around them, offers a way forward. In Information Literacy and Critical Thinking: Using Perspective Transformation to Break Information Bubbles (2025, ALA) Amanda Nichols Hess invites academic librarians to consider critical librarianship, pedagogy, and information literacy instruction in tandem with transformative learning theory, demonstrating tangible ways to integrate these concepts into their practice. Readers will discover an overview of critical library pedagogy and transformative learning theory, showing how reflection and action lie at the core of both ideas; in-depth exploration of the ten phases of the perspective transformation process and how they relate to key facets of critical librarianship, critical pedagogy, and critical information literacy; important theoretical and research viewpoints that elucidate perspective transformation; real-world scenarios modelling how one's own praxis can support learners; and a myriad of ideas, reflection questions, opportunities for action, and additional resources to spur readers to look beyond their own information bubbles and facilitate environments where learners can do the same. Guest: Amanda Nichols Hess, PhD, is the coordinator of instruction and research help at Oakland University in Rochester, Michigan. She holds a PhD in educational leadership, an education specialist certificate in instructional technology, and a Master of Science in information. Amanda's research focuses on information literacy, instructional design, online learning, and the intersections of these topics—particularly in library-centric professional learning. Her work has been published in College & Research Libraries, Communications in Information Literacy, Journal of Academic Librarianship, and portal: Libraries and the Academy, among other venues. In addition to editing and authoring books for ACRL and ALA Editions, Amanda also authored Transforming Academic Library Instruction (Rowman & Littlefield, 2019). Host: Dr. Michael LaMagna is the Information Literacy Program & Library Services Coordinator and Professor of Library Services at Delaware County Community College. Learn more about your ad choices. Visit megaphone.fm/adchoices

From July 1, 2022: When a Russian missile recently struck a TV tower in Kyiv, near Babyn Yar, the site of Nazi mass murders during the Holocaust, some saw the attack as a potent symbol of the tragic occurrence of violence in Ukraine. To talk through the historical significance of the attack, Lawfare Managing Editor Tyler McBrien sat down with Maksym Rokmaniko, an architect, designer, entrepreneur, and director at the Center for Spatial Technologies in Kyiv, and Linda Kinstler, a PhD candidate in the rhetoric department at UC Berkeley.In her recent New York Times essay, the Bloody Echoes of Babyn Yar, Linda wrote, "the current war in Ukraine is so oversaturated with historical meaning, it is unfolding on soil that has absorbed wave after wave of the dead, where soldiers do not always have to dig trenches in the forest because the old ones remain."Linda's writing has appeared in the New York Times, the Washington Post, the Atlantic and Jewish Currents, where she recently reported on the Babyn Yar Holocaust Memorial center. Linda is also the author of Come to This Court and Cry: How the Holocaust Ends, which is out in the U.S. on August 23rd, from Public Affairs.Tyler, Linda and Maksym discuss the history of Babyn Yar as a sight and symbol, the role of open source investigative techniques and forensic modeling in the documentation of war crimes, the battle over historical narratives, memorialization and memory, as well as the limits of the law in achieving justice for victims of negation and genocide.To receive ad-free podcasts, become a Lawfare Material Supporter at www.patreon.com/lawfare. You can also support Lawfare by making a one-time donation at https://givebutter.com/lawfare-institute.Support this show http://supporter.acast.com/lawfare. Hosted on Acast. See acast.com/privacy for more information.

John Nelson earned a PhD in New Testament and Christian Origins from the University of Edinburgh in 2023. He writes for the Substack Behind the Gospels.His thesis is the first book-length study of Jesus' physical appearance in the Gospels. He runs a weekly Substack called "Behind the Gospels" which aims to make Biblical studies accessible to all.Timestamps:0:00 - Was Jesus Really Born on Christmas Day?2:51 - Are the Birth Narratives Attempts at History?6:34 - Where Was Jesus Actually Born?16:19 - Were the Birth Narratives Added Later?20:54 - Was Mary Really a Virgin?32:57 - Why Does Nobody Else Mention the Virgin Birth?37:39 - Was Jesus a Product of Adultery? 42:22 - Was Jesus Born in a Manger?48:07 - Who Are the Magi?54:05 - Was the Star Really a Star?01:00:03 - Did Herod Really Order a Slaughter of Infants?01:06:26 - Is the Christmas Story Anti-Imperial?01:13:13 - Are Christmas Trees a Pagan Idol?01:16:12 - John's Book and the Upcoming Tour

Timeline Mitopure Gummies — The #1 Urolithin A supplement for energy and healthy aging, now in delicious strawberry gummies. Get 20% off at timeline.com/vanessa What if the real driver of skin aging isn't wrinkles or sun damage — but "zombie" senescent cells hiding in your skin? In this episode of the Optimal Protein Podcast, Vanessa sits down with Dr. Alessandra Zonari, PhD — a stem cell biologist and longevity scientist — for a fascinating deep dive into the new peptide science behind skin aging, inflammation, and biological age. BOOST YOUR COLLAGEN & ELASTIN with RED LIGHT THERAPY! Save 25% on all Tone Lux Red Light therapy with the code HOLIDAY25! Learn more about the  TONE LUX Crystal red light therapy mask and the brand new accessory the TONE LUX CONTOUR for the neck and décollete You'll discover: What senescent "zombie" skin cells actually are — and why they don't just age themselves, but affect the surrounding tissue How inflammation in the skin can quietly accelerate collagen breakdown and visible aging Why skin aging speeds up during fat loss, perimenopause, and menopause How scientists are now measuring the biological age of skin, not just how it looks The surprising role of peptides in signaling skin cells to behave more youthfully Why some common "anti-aging" approaches may miss the real drivers of aging What makes lip skin biologically different — and why it tends to age faster than the rest of the face Why nighttime repair, autophagy, and even red light therapy may matter more than you think This conversation goes far beyond skincare routines. It explores the mechanisms of aging at the cellular level, how lifestyle choices influence skin health, and why skin may be one of the most overlooked markers of longevity. If you're interested in skin health, peptides, collagen, inflammation, fat loss, or aging well, this episode will completely change how you think about your skin. Mentioned in this episode: OneSkin is powered by the breakthrough peptide OS-01, the first ingredient proven to reduce skin's biological age. I use the OS-01 Face and Eye formulas daily—they've transformed my skin's smoothness, firmness, and glow. Visit oneskin.co/VANESSA and use code VANESSA for 15% off your first purchase. Vanessa discusses how red light therapy supports mitochondrial health, muscle recovery, circulation, and skin health as part of an evidence-based approach to fat loss and metabolic optimization. Explore the Tone LUX red light therapy collection at

Who's in the Room?: A Guide to Public Relations from the Black Professional Perspective (Kendall Hunt Publishing, 2025) has been created to serve as a resource that is both an academic and industry text in public relations practice. The book focuses on growth and empowerment in public relations through the implementation of inclusionary practices. It is centered in the voice of the Black public relations professional. Featuring contributions of pioneers and the experiences of current trailblazers, the book explores themes of access, representation, and accountability in the field. The authors examine the nuanced challenges and triumphs of navigating the field as Black professionals. They offer guidance for students and new professionals, as well as actionable recommendations for organizations and individuals seeking to become more equitable and inclusive. Jamila Cupid, Ph.D. is a university professor who trains university students in the practice of public relations. She built her career as a public relations and digital media professional, with expertise in research and strategy, working in New York City and Washington, DC for several years. She earned a BA in English from Boston University, then an MA in Human Communication and PhD in Mass Communication and Media Studies with a certificate in International Communication from Howard University. In addition to her industry experience and academic training in the United States, she has studied and conducted research in the Caribbean and South America. She examines international, intercultural, and multicultural public relations in the areas of campaigns, branding, organizational structure, crisis management, relationship building, and social media. Joell Myescha is an award-winning public relations executive, media strategist, and founder of Morris Street Media, a firm known for high-impact campaigns and storytelling that center underrepresented voices. With over 20 years of experience, she has led successful PR and content initiatives across TV, film, and digital media, including the 2024 PBS GOSPEL Live! campaign, which earned a Silver Anthem Award. Her work blends creative vision with strategic execution, focusing on social justice, cultural impact, and audience engagement. A graduate of Boston University, she holds a BA in International Relations. Reighan Gillam is Associate Professor in the Department of Latin American, Latino, and Caribbean Studies at Dartmouth College. Her research examines the ways in which Afro-Brazilian media producers foment anti-racist visual politics through their image creation. She is the author of Visualizing Black Lives: Ownership and Control in Afro-Brazilian Media (University of Illinois Press). Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/african-american-studies

Who's in the Room?: A Guide to Public Relations from the Black Professional Perspective (Kendall Hunt Publishing, 2025) has been created to serve as a resource that is both an academic and industry text in public relations practice. The book focuses on growth and empowerment in public relations through the implementation of inclusionary practices. It is centered in the voice of the Black public relations professional. Featuring contributions of pioneers and the experiences of current trailblazers, the book explores themes of access, representation, and accountability in the field. The authors examine the nuanced challenges and triumphs of navigating the field as Black professionals. They offer guidance for students and new professionals, as well as actionable recommendations for organizations and individuals seeking to become more equitable and inclusive. Jamila Cupid, Ph.D. is a university professor who trains university students in the practice of public relations. She built her career as a public relations and digital media professional, with expertise in research and strategy, working in New York City and Washington, DC for several years. She earned a BA in English from Boston University, then an MA in Human Communication and PhD in Mass Communication and Media Studies with a certificate in International Communication from Howard University. In addition to her industry experience and academic training in the United States, she has studied and conducted research in the Caribbean and South America. She examines international, intercultural, and multicultural public relations in the areas of campaigns, branding, organizational structure, crisis management, relationship building, and social media. Joell Myescha is an award-winning public relations executive, media strategist, and founder of Morris Street Media, a firm known for high-impact campaigns and storytelling that center underrepresented voices. With over 20 years of experience, she has led successful PR and content initiatives across TV, film, and digital media, including the 2024 PBS GOSPEL Live! campaign, which earned a Silver Anthem Award. Her work blends creative vision with strategic execution, focusing on social justice, cultural impact, and audience engagement. A graduate of Boston University, she holds a BA in International Relations. Reighan Gillam is Associate Professor in the Department of Latin American, Latino, and Caribbean Studies at Dartmouth College. Her research examines the ways in which Afro-Brazilian media producers foment anti-racist visual politics through their image creation. She is the author of Visualizing Black Lives: Ownership and Control in Afro-Brazilian Media (University of Illinois Press). Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

From day one of COVID, guest James Lyons-Weiler, Phd, has been saying that using PCR tests "as the primary driver of pandemic policy would guarantee a tidal wave of false positives, distort epidemiology, and weaponize diagnostic noise as public fear." He was absolutely right, and yet "public health" has not yet learned its lesson and threatens to make a mess of it again with avian flu. Luckily, Dr. Lyons-Weiler has a plan. Tune in!Reference Linkshttps://informedchoicewa.substack.com/https://popularrationalism.substack.com/p/avian-flu-pandemic-or-pandemoniumhttps://ipak-edu.org/https://ipaknowledge.org/https://publichealthpolicyjournal.com/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Documentary "If You Tell Anyone"-The Brett Allan Show If You Tell Anyone… is a Documentary written and produced by Norman Fried, PhD; Nathan Spiteri, and Dean Love.   This film is based on the true-life story of Australian born author/actor Nathan Spiteri, adapted from his memoir Toy Cars; One Man's Journey from Trauma to Triumph. Raped at the age of 8 years old by a man in a public locker room, Nathan endured five years of repeated abuse. His abuser kept him quiet by telling him… “If you tell anyone, I'll kill you and I'll kill your whole family.” As in all abusive relationships, Nathan was groomed and manipulated to believe that what was happening to him was his own fault.  Nathan was unable to tell anyone about what had happened to him for 25 years. As a result, his adult life spiraled into addictions to alcohol, drugs and sex. He became suicidal before finally breaking down and telling someone what had happened to him.   Nathan is now able to tell his story through the artistic structure of this documentary. The film explores the arch of transformation that young Nathan underwent as he discovered a more redemptive way of living and healing. Through real footage of trauma therapy sessions, Nathan and Dr. Norman Fried describe how healing from child sex abuse is possible.   The goal of the film is to inspire other abuse victims to speak up and to get the help they need; while also helping parents and other caretakers recognize the dangers and symptoms of a child who may be being sexually abused.   This is a powerful and cautionary story about the complexities of childhood trauma and its aftermath, starring Nathan Spiteri and Norman Fried, and directed by three-time Emmy Award winning documentary filmmaker Dean Love.   Learn more about Nathan Spiteri HERE.   Nathan Spiteri's TEDx Talk can be found HERE. Learn more about your ad choices. Visit megaphone.fm/adchoices

You've probably heard of the Talmud–but what is it really, and how do/can contemporary Jews relate to this crucial text? In this session, Rabbinic Intern Rebecca Thau will discuss all things Talmud with Rabbi Ethan Tucker, PhD, President and Rosh Yeshiva at Hadar.A renowned expert in Jewish law,  Rabbi Tucker was ordained by the Chief Rabbinate of Israel and earned a doctorate in Talmud and Rabbinics from the Jewish Theological Seminary and a B.A. from Harvard College. Co-founder of Kehilat Hadar and winner of the first Grinspoon Foundation Social Entrepreneur Fellowship, Rabbi Tucker was named one of America's Top 50 Rabbis by Newsweek in 2011 and 2012. He is the co-author of Gender Equality and Prayer in Jewish Law and hosts the podcast Responsa Radio.

We celebrate the birth of Jesus as well as a great 2025 MLB Season (if you are a Dodgers fan).

In this first episode of The Dance between Experience and Expertise, Tara and Jamie discuss how to prepare fro a PhD enrolment.

#ThisMorning | #Aging in Place: Growing #Older at #Home | Erin Harrell, PhD., National Institute on Aging | #Tunein: broadcastretirementnetwork.com #Aging, #Finance, #Lifestyle, #Privacy, #Retirement, #Wellness

Who's in the Room?: A Guide to Public Relations from the Black Professional Perspective (Kendall Hunt Publishing, 2025) has been created to serve as a resource that is both an academic and industry text in public relations practice. The book focuses on growth and empowerment in public relations through the implementation of inclusionary practices. It is centered in the voice of the Black public relations professional. Featuring contributions of pioneers and the experiences of current trailblazers, the book explores themes of access, representation, and accountability in the field. The authors examine the nuanced challenges and triumphs of navigating the field as Black professionals. They offer guidance for students and new professionals, as well as actionable recommendations for organizations and individuals seeking to become more equitable and inclusive. Jamila Cupid, Ph.D. is a university professor who trains university students in the practice of public relations. She built her career as a public relations and digital media professional, with expertise in research and strategy, working in New York City and Washington, DC for several years. She earned a BA in English from Boston University, then an MA in Human Communication and PhD in Mass Communication and Media Studies with a certificate in International Communication from Howard University. In addition to her industry experience and academic training in the United States, she has studied and conducted research in the Caribbean and South America. She examines international, intercultural, and multicultural public relations in the areas of campaigns, branding, organizational structure, crisis management, relationship building, and social media. Joell Myescha is an award-winning public relations executive, media strategist, and founder of Morris Street Media, a firm known for high-impact campaigns and storytelling that center underrepresented voices. With over 20 years of experience, she has led successful PR and content initiatives across TV, film, and digital media, including the 2024 PBS GOSPEL Live! campaign, which earned a Silver Anthem Award. Her work blends creative vision with strategic execution, focusing on social justice, cultural impact, and audience engagement. A graduate of Boston University, she holds a BA in International Relations. Reighan Gillam is Associate Professor in the Department of Latin American, Latino, and Caribbean Studies at Dartmouth College. Her research examines the ways in which Afro-Brazilian media producers foment anti-racist visual politics through their image creation. She is the author of Visualizing Black Lives: Ownership and Control in Afro-Brazilian Media (University of Illinois Press). Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/communications

Join the So Money Members Club today and get your first two months FREE. Offer expires December 31.In this Ask Farnoosh episode, Farnoosh answers listener questions on the tax implications of receiving Bitcoin as a gift, including how cost basis and capital gains work when you sell, plus smart ways to negotiate benefits beyond salary at a small business, from retirement matches to bonuses and potential equity alternatives. She also offers guidance for PhDs entering a competitive job market, shares practical ways to invest in your health for long-term financial wellbeing, and explains when withdrawals from a whole life insurance policy may be taxable. Hosted on Acast. See acast.com/privacy for more information.

I continue to research human communication and find the vast majority of everything we communicate is subjective. We are seldom discussing facts and right, wrong, black, white issues. They may feel so to us, but if pressed we'd need to admit that what we are arguing or advocating for is not fact. The topic or issue is not unanimously proven. But it's efficient to just cite our perspective as truth. It takes time and effort to really understand and consider all sides. So I sat down with an expert on this concept. Wendy K. Smith has a PhD in organizational behavior from Harvard and is the Dana J. Johnson Professor of Management and faculty director of the Women's Leadership Initiative at University of Delaware. She is an expert on organizational paradoxes, exploring how leaders and individuals effectively respond to contradictory, yet interdependent demands. She spends her time continually working to better manage the paradoxes of life that we all face. Wendy is co-author of the book,"Both/And Thinking: Embracing Creative Tensions to Solve Your Toughest Problems.” This topic is of utmost importance to me as I continue to see our world in conflict and people more isolated. Sign up for your $1/month trial period at shopify.com/kevin Go to shipstation.com and use code KEVIN to start your free trial. Learn more about your ad choices. Visit megaphone.fm/adchoices

Independent Veteran candidate, retired Army Lieutenant Colonel, PhD, ultra-marathon champion, and living kidney donor Matt Cavanaugh is a damn impressive leader. And he joins Independent Americans host Paul Rieckhoff from Colorado's 5th district for an unfiltered, high-energy conversation on why “America is not okay” and why he believes voters are trapped in another “Alien vs. Predator” election where, if either major party wins, the people lose. From NORAD's backyard in the shadow of Pikes Peak, he makes the case that his home turf—majority independent, home to five military bases and Team USA—is the best district in America for an independent veteran Congressional candidate to break through.​ Cavanaugh explains why his campaign logo features a buffalo and how American bison running straight into the storm became his metaphor for political courage in a district that's ready to send an independent veteran to Congress. He tears into gerrymandering, shutdowns that burned billions, and a political class that left every newborn with six-figure national debt stapled to their birth certificate, while calling for a new generation of “rational vertebrates” with the backbone to stand up for Article One of the Constitution.​ Matt and Paul also fly into Matt's living kidney donation—why he voluntarily gave a kidney at Walter Reed to a stranger in Seattle, how that transplant chain saved eight lives and saves taxpayers far more than it costs, and how serving others from combat to transplantation to running for office is his answer to these “times that try men's souls.” Paul opens the episode with a rapid-fire breakdown of Trump's marijuana order and “war dividend” troop checks, the Trump–Kennedy Center rename push, the rising risk of war near Venezuela, Ukraine's 1,390th day of full-scale war, and major movement on extremism inside the Coast Guard, plus culture, sports, and hope—from Avatar and SpongeBob to Football Friday picks, polar bears, skiing with kids, and New York City marathon memories. It's a fierce and fun way to close out a wild week.  Because every episode of Independent Americans with Paul Rieckhoff breaks down the most important news stories--and offers light to contrast the heat of other politics and news shows. It's independent content for independent Americans. In these trying times especially, Independent Americans is your trusted place for independent news, politics, inspiration and hope. The podcast that helps you stay ahead of the curve--and stay vigilant. -WATCH video of this episode on YouTube now. -Learn more about his campaign for Congress. -Get a copy of his book Best Scar Wins and take a  minute and read more about his experience of becoming a kidney donor. -Learn more about Paul's work to elect a new generation of independent leaders with Independent Veterans of America. -Join the movement. Hook into our exclusive Patreon community of Independent Americans. Get extra content, connect with guests, meet other Independent Americans, attend events, get merch discounts, and support this show that speaks truth to power.  -Check the hashtag #LookForTheHelpers. And share yours.  -Find us on social media or www.IndependentAmericans.us.  -And get cool IA and Righteous hats, t-shirts and other merch now in time for the holidays.  -Check out other Righteous podcasts like The Firefighters Podcast with Rob Serra, Uncle Montel - The OG of Weed and B Dorm.  Independent Americans is powered by veteran-owned and led Righteous Media. Spotify • Apple Podcasts • Amazon Podcasts  Ways to watch: YouTube • Instagram  X/Twitter • BlueSky • Facebook  Ways to listen:Social channels: Learn more about your ad choices. Visit megaphone.fm/adchoices

Watch every episode ad-free & uncensored on Patreon: https://patreon.com/dannyjones John Vervaeke, PhD is a philosopher and cognitive scientist. He is an associate professor and award-winning lecturer at the University of Toronto, teaching in the Department of Psychology. His work and research is far-ranging, including topics such as human intelligence, rationality, wisdom, and AI. SPONSORS https://hexclad.com/danny - Get up to 50% off during Hexclad's Holiday sale! https://mizzenandmain.com - Use code DANNY20 for 20% off. https://shopify.com/dannyjones - Sign up for your one-dollar-per-month trial & start selling today. https://whiterabbitenergy.com/?ref=DJP - Use code DJP for 20% off. EPISODE LINKS John's YouTube channel:  @johnvervaeke Awakening From the Meaning Crisis: https://a.co/d/hDXSVBs https://johnvervaeke.com FOLLOW DANNY JONES https://www.instagram.com/dannyjones https://twitter.com/jonesdanny OUTLINE 00:00 - The meaning crisis 05:37 - Jordan Peterson 13:19 - The cognitive continuum theory 20:20 - Flow state & higher consciousness 32:22 - The universal cognitive dimension 36:40 - Biological function of flow state 46:19 - The art of human memory 50:12 - AI & the biometric economy 1:02:44 - Social media nudging & stealing elections 1:09:30 - AI griefbots 1:17:31 - Why AI can't replace love 1:23:55 - Fear of death drives the human psyche 1:32:37 - What happens when we die? 1:38:17 - "Third man" experiences & sensed presences 1:46:20 - What dreams are trying to tell you 1:58:35 - Precognition 2:07:39 - Consciousness: The Holy Grail of cognitive science 2:22:28 - Why humans have higher consciousness than other beings 2:27:29 - What we've replaced religion with 2:33:38 - Intellectual reason vs. religion Learn more about your ad choices. Visit podcastchoices.com/adchoices

What if confidence, not talent, was the real driver of performance?   In this episode of The High Performance Mindset, we reveal why confidence is a business strategy, not a soft skill. Our national research shows 81% of workers are drawn to organizations that prioritize confidence and when confidence is low, productivity, culture, and retention suffer.   If you are a leader, this matters.  

In this episode I am joined by Dr Judith Shoemaker and Dr Karen Gellman. They talk about Postural Rehabilitation and why horses may not respond to treatment. It is often due to underlying imbalances and they discuss different areas you'll want to look at. Free webinar about Postural Rehabilitation.About the Guests: Judith M. Shoemaker, DVM, is well known practitioner and educator in integrative veterinary medicine and therapy. A 1980 graduate of the University of Georgia College of Veterinary Medicine, Dr. Shoemaker's 32 year experience in clinical practice focuses on holistic medicine and therapy, utilizing chiropractic, acupuncture, state of the art dentistry and farriery, and multiple other complementary modalities. Licensed in 16 states, she provides comprehensive maintenance, therapeutic management and consultation for top competitors, and companion animals, in the US and internationally. Dr. Karen Gellman holds DVM and PhD degrees from Cornell University in animal locomotion biomechanics. She has advanced training and certification in veterinary acupuncture and veterinary chiropractic, and has practiced these and other holistic modalities since 1995. She teaches about posture, biomechanics and holistic therapies to veterinarians world wide, is research director of Maximum Horsepower Research and practices holistic veterinary medicine in New York State, and on a consulting basis. In 2024, Dr. Gellman revived the popular Postural Rehabilitation program, with co-teachers Dr. Judith Shoemaker and Alexander Teacher Elizabeth Reese, offering Postural Rehabilitation Professional training online for equine professionals and Postural Rehabilitation for Horses for riders and horse enthusiasts. About the Host:Karen Rohlf, author and creator of Dressage Naturally, is an internationally recognized clinician who is changing the equestrian educational paradigm. She teaches students of all disciplines and levels from around the world in her clinics and the Dressage Naturally virtual programs. Karen is well known for training horses with a priority on partnership, a student-empowering approach to teaching, and a positive and balanced point of view. She believes in getting to the heart of our mental, emotional, and physical partnership with our horses by bringing together the best of the worlds of dressage and partnership-based training.  Karen's passion for teaching extends beyond horse training. Her For The Love Of The Horse: Transform Your Business program is a result of her commitment to helping heart-centered equine professionals thrive so that horses may have a happier life in this industry. Resource Links: FREE Postural Rehabilitation Webinar with Dr Gellman: https://dnkarenr.krtra.com/t/xY1hza5wq0rK AUDIOBOOK Dressage Naturally: https://go.dressagenaturally.net/book-audio-573092 Naturally VIDEO CLASSROOM: https://dnc.dressagenaturally.net/ Ask a question or leave a message for the pod: https://www.speakpipe.com/AskKarenAnything How To Create A Happy Athlete course: https://go.dressagenaturally.net/hats...

Michael P. Masters, PhD, is a professor of biological anthropology at Montana Technological University and the author of several books exploring the hypothesis that alien visitors may be human time travelers from the future. The most recent titles are "The Extratempestrial Model," a work of nonfiction, and the novel "Revelation: The Future Human Past." www.idflyobj.com/books-%26-merchwww.youtube.com/@MichaelPMasterswww.idflyobj.com Download the app or ask Perplexity anything at https://pplx.ai/rogan. This video is sponsored by BetterHelp. Visit https://BetterHelp.com/JRE This episode is brought to you by Monster Ultra. Zero Sugar, Flavor Unleashed. Visit https://monsterenergy.com to learn more. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Full Show Notes: BenGreenfieldLife.com/nicknorwitz In this episode with Dr. Nick Norwitz, you’ll get to discover how a Harvard-trained MD/PhD used a simple, eyebrow-raising experiment with Oreos to challenge conventional thinking on cholesterol, metabolism, and the stories told about health. We dive into his now-viral “Oreo experiment,” where adding Oreos to a ketogenic diet dropped his LDL cholesterol faster and more effectively than a high-intensity statin—an unexpected outcome that opens the door to deeper questions about lipid markers, risk factors, and how the body actually processes dietary fats. Nick Norwitz MD PhD is a researcher-educator whose mission is to “Make Metabolic Health Mainstream.” He graduated Valedictorian from Dartmouth College, majoring in Cell Biology and Biochemistry, before completing his PhD in Metabolism at the University of Oxford and his MD at Harvard Medical School. Nick has made a name for himself as a clinical research and metabolic health educator, speaking and writing on topics ranging from brain health, the microbiome, mental health, muscle physiology, mitochondrial function, cholesterol and lipids, and so on. Episode Sponsors: CAROL Bike: The science is clear—CAROL Bike is your ticket to a healthier, more vibrant life. And for a limited time, you can get $100 off yours with the code BEN. Don't wait any longer, join over 25,000 riders and visit carolbike.com/ben today. LVLUP Health: I trust and recommend LVLUP Health for your peptide needs as they third-party test every single batch of their peptides to ensure you’re getting exactly what you pay for and the results you’re after! Head over to lvluphealth.com/BGL and use code BEN15 for a special discount on their game-changing range of products. Muse: Muse S Athena combines clinical-grade EEG and fNIRS technology to train your brain in real time while tracking sleep with 86% expert-level accuracy. Get 15% off at choosemuse.com/BENGREENFIELD or use code BENGREENFIELD at checkout. LeelaQ: Not only do LeelaQ’s products neutralize EMFs, increase ATP production, optimize HRV, and improve blood flow, but they've been third-party proven to do so in placebo-controlled double-blind studies. Visit leelaq.com and use code BEN10 for 10% off. BlockBlueLight: BlockBlueLight BioLights are the only lights extensively tested and recommended by building biologist Brian Hoyer as truly flicker-free, ultra-low EMF, and circadian-friendly, with three modes (day, evening, night) that support natural rhythms and optimize sleep quality. Get 10% off your first order at blockbluelight.com/Ben (discount autoapplied at checkout).See omnystudio.com/listener for privacy information.

We're discussing the feedback from Sooz Review of Jaws, and why people are real worked up about it. We learn about a woman who changed her gender on LinkedIn only to get a 400% increase in page views, so obviously we're mad about it. Sarah explains why drones are being used in warfare and it feels more dangerous than you'd think. Susie describes a study that had a man dressed as Batman entering a subway car, and the surprising effect it had on passengers, but the real surprise was the conclusions it gave scholars. We learn about a man who is wearing ridiculous pants to win a jeans contest for absolutely no reason, and Sarah cannot quit laughing at him. Plus, we hear about a trial where a mistress was fined almost $2M for breaking up a marriage, while the man was not held accountable in any way.Brain Candy Podcast Website - https://thebraincandypodcast.com/Brain Candy Podcast Book Recommendations - https://thebraincandypodcast.com/books/Brain Candy Podcast Merchandise - https://thebraincandypodcast.com/candy-store/Brain Candy Podcast Candy Club - https://thebraincandypodcast.com/product/candy-club/Brain Candy Podcast Sponsor Codes - https://thebraincandypodcast.com/support-us/Brain Candy Podcast Social Media & Platforms:Brain Candy Podcast LIVE Interactive Trivia Nights - https://www.youtube.com/@BrainCandyPodcast/streamsBrain Candy Podcast Instagram: https://www.instagram.com/braincandypodcastHost Susie Meister Instagram: https://www.instagram.com/susiemeisterHost Sarah Rice Instagram: https://www.instagram.com/imsarahriceBrain Candy Podcast on X: https://www.x.com/braincandypodBrain Candy Podcast Patreon: https://www.patreon.com/braincandy (JOIN FREE - TONS OF REALITY TV CONTENT)Brain Candy Podcast Sponsors, partnerships, & Products that we love:Get $35 off Aura's best-selling Carver Mat frames - named #1 by Wirecutter - by going to https://auraframes.com and using promo code BRAINCANDY at checkout.For 20% off your order, head to https://reliefband.com and use code BRAINCANDYSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Bret Weinstein, PhD, is an evolutionary biologist, author, and co-host of “The DarkHorse Podcast” with his wife, biologist Heather Heying. They are the co-authors of “A Hunter-Gatherer's Guide to the 21st Century: Evolution and the Challenges of Modern Life.”www.bretweinstein.netwww.youtube.com/@DarkHorsePodwww.penguinrandomhouse.com/books/618153/a-hunter-gatherers-guide-to-the-21st-century-by-heather-heying-and-bret-weinstein/ Download the app or ask Perplexity anything at https://pplx.ai/rogan Get a free welcome kit with your first subscription of AG1 at https://drinkag1.com/joerogan Try ZipRecruiter FOR FREE at https://ziprecruiter.com/rogan Learn more about your ad choices. Visit podcastchoices.com/adchoices