Podcasts about Nicotinamide

Today, I'm joined by Teo Soleymani, MD—a double board-certified dermatologist, fellowship-trained Mohs and facial reconstructive surgeon, and an expert in all things skin cancer—plus, he's as entertaining as he is knowledgeable. If you've ever wondered whether you should slather on sunscreen religiously, or if embracing more sunlight is actually good for you, we're here to offer the clarity and nuance that's so often missing from the conversation. Listeners of this podcast can receive 15% off of SunPowder when you go to sunpowder.co/discount/NAT15 (it's .co not .com or else you won't find it).   What we discuss: Sun exposure: fear vs. benefits debate ... 00:06:38 Genetics vs. sun in driving skin cancer risk ... 00:09:04 Types of skin cancer explained ... 00:10:38 HPV, environmental toxins, and non-UV causes ... 00:22:35 Burning vs. safe sun—practical advice ... 00:21:24 Sunscreen: mineral vs. chemical, what matters ... 00:36:01 Problems with spray sunscreens ... 00:40:45 Melanin, UV damage, and skin aging ... 00:13:40 Melasma: hormones and stubborn pigmentation ... 00:47:19 Estrogen, collagen, and topical supplements ... 00:49:18 Astaxanthin and polypodium—internal sun protection ... 00:56:01 Nicotinamide: strong evidence for cancer prevention ... 01:04:11 Sunpowder supplement: trials and benefits ... 01:07:43 Laser resurfacing and reduced cancer risk ... 01:12:33 Genetics, immune health, and testing limits ... 01:15:31 Where to find Sunpowder + connect with Teo ... 01:18:53   Our Amazing Sponsors: LVLUP - Neuro Re-Generate the world's first liposomal triple peptide formula, designed to support mental clarity, focus, and overall brain health. Visit www.lvluphealth.com and use code NAT for 20% off your order. Qualia - Senolytic - Clinically tested formula with 9 plant-based, vegan ingredients designed to help your body clear out zombie cells—so you can feel younger, faster. Visit qualialife.com/nathalie and use promo code NATHALIE to save 15% Young Goose L.A.D.R. Serum -  Powered by light-activated DNA repair enzymes, NAD+, and collagen peptides, it reverses damage while you go about your life. Sunlight? Red light therapy? It all helps this serum work smarter, not harder. Visit YoungGoose.com—use code NAT10 to get started, or 5NAT if you're an existing customer. Future-proof your face.   More from Nat:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group   More from Teo Soleymani: Website: www.californiadermatology.com and https://sunpowder.co/discount/NAT15 Instagram: @teosoleymanimd Instagram: @drinksunpowder  

In this episode of fx Medicine by BioCeuticals, host Lisa Costa-Bir speaks with naturopathic physician and nootropic expert Dr Greg Kelly about the evolving role of nootropics in supporting cognitive performance. Greg shares how plant-based and nutritional compounds - including bacopa (Bacopa monnieri), saffron (Crocus sativus), gotu kola (Centella asiatica), alpinia (Alpinia galanga), L-theanine, and nicotinamide riboside - can enhance focus, memory, motivation, and mental energy. The conversation explores how these agents work through key pathways such as acetylcholine signalling, neuroplasticity, and mitochondrial function. Greg also unpacks the concept of brain resource depletion, the impact of modern distractions, and why nootropics are just as relevant for healthy individuals as they are for those with cognitive challenges. He offers practical guidance on stacking, cycling, and how to support non-responders by returning to foundational naturopathic principles like sleep, nutrition, and stress management. This episode is packed with practical, science-backed takeaways for anyone looking to optimise focus, memory, motivation, and overall cognitive performance - whether in clinical practice or everyday life. Covered in this episode: (00:57) Welcome Greg Kelly (02:02) What are nootropics? (05:05) Why do we become depleted? (12:23) L-theanine (17:51) Bacopa (24:25) Saffron (30:01) Gingko (33:17) Alpinia & Ginger (37:29) Gotu Kola (40:29) Nicotinamide riboside (44:19) Chronic stress and brain damage (46:45) Are nootropics essential for some patients? (51:30) Safety issues (55:22) Thanks and final remarks Find today's transcript and show notes here: https://www.bioceuticals.com.au/education/podcasts/nootropics-beyond-caffeine-power-up-your-brain-with-lisa-costa-bir-and-dr-greg-kelly Sign up for our monthly newsletter for the latest exclusive clinical tools, articles, and infographics: https://login.bioceuticals.com.au ***DISCLAIMER: The information provided on fx Medicine by BioCeuticals is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.***

NR may just be a waste of money, safe but ineffective. NMN seems similarly useless in humans, but it may not even be safe.

The metabolism of NAM may deplete our methylation capacity, interfering with the normal metabolism of hormones and neurotransmitters, and produce a neurotoxic compound in the process.

In this episode of the Heal Nourish Grow podcast, Dr. Chris Rhodes, a nutrition scientist, discusses his journey into the fields of longevity and fasting. He explains the significance of autophagy and shares his personal experiences with fasting. Dr. Rhodes also introduces Mimio, a product designed to mimic the benefits of fasting at the molecular level, and discusses the clinical studies that support its efficacy. The conversation delves into the science behind Mimeo's ingredients and their roles in promoting healthspan and longevity. Visit Mimio to learn more and get an awesome discount! Takeaways Fasting can activate longevity bio programs within our cells. Autophagy is a crucial process for cellular health and longevity. GLP-1 drugs like Ozembic may positively impact longevity pathways. Mimeo is designed to mimic the benefits of fasting without actual fasting. Clinical studies show Mimeo can improve metabolic health markers. The formulation of Mimeo includes powerful anti-aging molecules. Nicotinamide plays a key role in cellular energy and metabolism. Using Mimeo can enhance the benefits of shorter fasting periods. Maintaining a balance between mTOR activation and fasting pathways is essential for health. https://youtu.be/CidbXEJcj3k Episode transcript Cheryl McColgan (00:00.834)Hey everyone. Welcome to the Heal Nourish Grow Podcast. I don't even know the name of my own podcast. It's loving my words today. But anyway, I'm really excited about today's guest. I'm here with Dr. Chris Rhodes and he is a nutrition scientist. I'll let him better describe himself, but you will have heard his full bio, of course, before this, but I always like to start out, Dr. Rhodes, with just having you kind of share in your own words, what brought you into this space? What made you passionate about working with Mimeo Health and the technology there. Like what led you to this point? Dr. Chris Rhodes (00:32.962)Yeah, great question. Really happy to be here, Cheryl. Thanks for having me on. really got me interested into the longevity space, the healthy aging space, and eventually the fasting space was coming out of college. I got my BS in biochemistry from Leroy LaMaria Mount University, but like a lot of college kids didn't really know what I wanted to do there. So to try and figure that out, took an immunology fellowship at Stanford, just kind of pouring through all the research I could get my hands on going to all these seminars, and eventually came across the longevity research. And I thought that was so fascinating because it was this thing that used to be relegated to myth and legend, right? It was like Ponce de Leon and the Fountain of Youth. And now it's this very active, very rigorous area of scientific research with a ton of funding and a ton of companies and a ton of government and scientific attention on it. And it's one of those things that helps with everything, right? If you can solve aging, then you can pretty much also solve disease because by and large, most young folks don't get disease. really see that aging is something that's an underlying factor in every disease that happens. So if you can tackle these fundamental issues of aging at the cellular level and really slow that process down, then you can not only potentially enhance lifespan but also healthspan at the same time, which I think is what we're all really going for, living our lives as well as possible and as best health as possible for as long long as we can. When you're in the healthy aging and longevity space, eventually you come across fasting because fasting is one of the only ways that we know of to reliably extend lifespan and health span helps to treat, prevent, or delay most major diseases. And the reason why that was so fascinating to me is because it does all of that without actually adding anything into the system, right? So it's not this superfood or this wonder drug that's doing al...

In this conversation, Buck and Dr. Nicola Conlon delve into the significance of NAD (Nicotinamide Adenine Dinucleotide) in aging and longevity. Dr. Conlon explains the role of NAD in cellular energy production, its decline with age, and the consequences of this decline on cellular repair and overall health. They discuss the importance of NAD in activating sirtuins, which are crucial for longevity, and explore the limitations of direct NAD infusions. The conversation concludes with insights into NAD precursors like NMN and NR, which can help increase NAD levels in the body.  Dr. Conlon is offering our listeners a special 20% discount on first purchase at www.nuchido.com. Use the code SAPIO20.

Send us a textIn this thought-provoking episode, I have the pleasure of hosting Dr. Chris Rhodes, the CEO and Co-Founder of Mimio Health. A trailblazer in the field of biomimetics and regenerative health, Dr. Rhodes shares his groundbreaking research on fasting, longevity, and tapping into the body's evolutionarily conserved mechanisms. With years of expertise and a passion for pushing the boundaries of human biology, he unveils how his work is redefining health optimization for the modern world.Our conversation dives deep into the science behind fasting and the revolutionary approach of biomimetic supplementation. Dr. Rhodes explains how Mimio Health's innovative formulation recreates the benefits of a 36-hour fast, activating metabolic pathways to enhance cellular health, longevity, and resilience—all without caloric restriction. From understanding the role of key metabolites like spermidine and nicotinamide to exploring the intersections of fasting, exercise, and mental clarity, this episode offers a masterclass in harnessing the power of biology to thrive in today's environment.This episode is a must-listen for anyone curious about unlocking their body's innate potential for healing and renewal. Dr. Rhodes' insights shed light on how fasting mimetics can improve everything from metabolic health to biological age, while also empowering listeners to take charge of their own well-being. Whether you're new to fasting or looking to optimize your health with cutting-edge science, this conversation will leave you inspired to explore what's possible when we align with the natural brilliance of our biology. Tune in and take the first step toward unlocking your full potential!Looking to discover your science and optimize your life?APPLY FOR HEALTH OPTIMIZATION COACHINGhttps://coaching.knowyourphysio.org/Links Mentioned in Today's Episode:Click HERE to save on BiOptimizers MagnesiumKey Points From This Episode:Evolutionarily preserved mechanisms [00:00:11]Fasting and longevity research [00:08:06]Hormetic stress and fasting benefits [00:12:00]Psychological benefits of fasting [00:16:00]Alternate day fasting benefits [00:21:23]Fasting mimetic supplement Mimio [00:37:09]Exercise and regenerative mechanisms [00:45:06]Autophagy activation by spermidine [00:47:01]Appetite suppression and metabolism [00:54:16]Exogenous ketone esters in formulations [01:01:13]Power of self-healing [01:09:08]PeopleDr. Chris RhodesLinkedIn Official WebsiteDave PetrinoLinkedInBooks and ReferencesElegans ResearchResource on C. elegansSpermidine and AutophagyResearch Article: Study on Spermidine and AutophagyHormetic Stress MechanismsNIH Resource: Hormesis in BiologySupport the show

There are people on TikTok and elsewhere are selling injections of NAD. Nicotinamide adenine dinucleotide is an energy molecule that some feel is the key to slowing the aging process. Normally, people take supplements like NMN and nicotinamide riboside to boost cellular NAD. Those supplements do have their share of clinical research but what about injecting NAD directly into the body? Preliminary research suggests cancer cells need NAD to grow so what does this mean for intravenous NAD treatments? When I tried to tell people about this on TikTok, my video was banned. While NAD shots may be one day be proven safe, until that happens, I feel this message needs to get out in the hopes that it helps those who has a history of cancer. If you have a history of cancer, please speak to your physician before supplementing with NAD via injections.   Supplement Facts Coffee Mug: https://joecannon.creator-spring.com/listing/supplement-facts-mug   Nicotinamide riboside research https://supplementclarity.com/podcast/nicotinamide-ribososide-human-studies-review-podcast-69/     NMN & NR videos https://youtube.com/playlist?list=PLmliBwDoqUP-KJu7BoXCVIaEWUQeIZfxg   Consultations  https://supplementclarity.com/private-consultations/     Get My Rhabdo Book   Education is the best defense against getting rhabdomyolysis. I've been teaching about rhabdo for over 10 years. If you are in the US, you can order my book directly from me. Purchase My Rhabdo Book Order on Amazon       Connect With Me Joe-Cannon.com SupplementClarity.com YouTube     About Me   For over 30 years I've been sorting nutrition facts from fiction, busting myths and helping people understand dietary supplements using clinical research as my litmus test.    I have an MS in exercise science and a BS in biology & chemistry. I've written several books, including Rhabdo, the first book about exercise-induced rhabdomyolysis.   Disclaimer   Episodes are for information only. I'm NOT a medical doctor. NO medical advice is given or implied. ALWAYS consult your physician for the best health advice for you. I participate in the Amazon Associates program which means if you click on a link to amazon and make a purchase, I may make a small commission at no extra cost to you.    

HEALTH NEWS   ·         Drinking plenty of water helps with a variety of conditions from obesity to migraines, researchers find ·         Nicotinamide riboside reduces airway inflammation in COPD ·         Food additive carrageenan could disrupt intestinal barrier and increase risk of type 2 diabetes ·         Should postmenopausal women eat soy? Researchers dispel myth about soy and cancer ·         Ultraprocessed food intake and psoriasis ·         Reduced vitamin K levels associated with increased abdominal obesity and other cardiovascular disease risk factors  

Soy, Ginko, Stress, Nicotinamide riboside, Norepinephrine, Peripheral neuropathy, autonomic nervous system sympathetic

Too busy to read the Lens? Listen to our weekly summary here! In this week's episode we discuss: Subconjunctival triamcinolone provides modest improvements in post-operative cataract surgery complications.  High chronic stress, as measured by allostatic load, proves to be associated with a higher risk for glaucoma.  Nicotinamide riboside, a form of vitamin B3, is a promising mitigator of pathological glaucomatous changes secondary to glucocorticoid exposure.  

In this episode, we explore Nicotinamide Mononucleotide (NMN), a molecule that's generating buzz in the world of longevity science. We'll delve into the science behind NMN, how it works in the body, and why it might be a key player in future anti-aging therapies. From cellular aging to enhancing both lifespan and healthspan, we'll uncover the potential of NMN in supporting everything from reproduction to DNA repair, cognitive function, and metabolic health.Starting with why this topic is crucial in our quest for longevity, we'll discuss how NMN functions as a direct precursor to NAD+, a molecule vital for cellular repair and reducing inflammation. We'll also explore how NMN supports mitochondrial function, protects against oxidative stress, and aids in DNA repair. Additionally, we'll cover the latest research on NMN's impact on metabolic health, cognitive function, and cardiovascular health, along with its role in delaying or reversing cellular senescence, a key driver of aging and age-related diseases.Whether you're new to this concept or looking to deepen your knowledge, this episode offers valuable insights into the ever-evolving world of longevity science. Don't miss this deep dive into how NMN might be a game-changer for your health and vitality.DISCLAIMER: The content in this podcast and related website is not intended to be a substitute for medical advice. It is not intended to be used to diagnose or treat, instead, it is designed to help educate and inspire. Always seek the advice of a professional medical practitioner or qualified health practitioner. Never ignore or disregard advice given to you based on information in this podcast or related website and do not delay in seeking medical advice.RESOURCES: Grab all the links and resources mentioned in this episode at https://www.nicolegoodehealth.com/the-goode-health-podcast/episode-53Mentioned in this episode:Join the Waitlist for Nicole's Book "Optimal YOU": https://www.nicolegoodehealth.com/optimal-you-book

As a dermatologist who treats skin cancers, I can't stress enough how important it is to understand skin cancers and how to prevent them. Skin cancers are one of the most common types of cancer, but with the right knowledge and actions, it's also one of the easiest to prevent and treat.  Regular check-ups, protecting your skin from the sun, and knowing your treatment options are key to keeping your skin healthy. If you have any concerns about your skin or need advice on how to treat or prevent skin cancer, it's important to talk to a dermatologist. Don't miss this week's podcast with Dr. Abigail Waldman, where she covers common and rare skin cancers, prevention and treatment methods. Key Takeaways: - The majority of skin cancers have a good prognosis when treated with surgery. - Sun exposure during childhood and cumulative sun exposure increase the risk of skin cancer. - Starting good sun protection habits early is really important for keeping your skin healthy in the long run - Discussing treatment options and preventive measures with a dermatologist is crucial. - Mohs surgery is considered the 'gold standard' for skin cancer treatment especially on the head and neck area. - If you need advice on how to treat or prevent skin cancer, it's important to talk to a dermatologist.  Check out Dr. Mina's top picks for skin care here. Download the free eBook 'Skincare Myths Busted' here. In This Episode: (9:52) Importance of Sun Protection (11:46) Nicotinamide and Sun Damage (13:49) How to Get Vitamin D (16:11) Laser Treatment for Pre-cancers and Early Skin Cancers (18:39) Merkel Cell Carcinoma (22:08 )Radiation Therapy for Skin Cancer (26:56) Overview of Mohs Surgery (34:33) Top Three Takeaways Dr. Abigail Waldman Abigail H. Waldman, MD, FAAD Director, Mohs and Dermatologic Surgery Center Director, Mohs Surgery, VA Boston Healthcare System Assistant Professor, Harvard Medical School Dermatology Leadership Title Director, Mohs and Dermatologic Surgery Center Director, Mohs Surgery, VA Boston Healthcare System Follow Dr. Waldman here: https://www.instagram.com/abby.waldmanmd/ https://www.youtube.com/@doctor-abby https://www.tiktok.com/@drabby6?_t=8otzFxFpbUF&_r=1 Follow Dr. Mina here:- https://instagram.com/drminaskin https://www.facebook.com/drminaskin https://www.youtube.com/@drminaskin For more great skin care tips, subscribe to The Skin Real Podcast or visit www.theskinreal.com Baucom & Mina Derm Surgery, LLC Email - scheduling@atlantadermsurgery.com Contact - (404) 844-0496 Instagram - https://www.instagram.com/baucomminamd/ Thanks for listening! The content of this podcast is for entertainment, educational, and informational purposes and does not constitute formal medical advice.

A groundbreaking study reveals that the over-the-counter supplement nicotinamide riboside can significantly improve walking ability in patients with peripheral artery disease (PAD). Participants in a six-month trial experienced a remarkable increase in walking distance, while those taking a placebo saw a decline. This affordable and accessible supplement offers new hope for millions living with this debilitating condition, potentially revolutionizing treatment options. #nicotinamide_riboside #peripheral_artery_disease #PAD #clinical_trial #vitamin_B3 McDermott, M.M., Martens, C.R., Domanchuk, K.J. et al. Nicotinamide riboside for peripheral artery disease: the NICE randomized clinical trial. Nat Commun 15, 5046 (2024). https://doi.org/10.1038/s41467-024-49092-5 nicotinamide riboside, peripheral artery disease, PAD, walking endurance, clinical trial, NAD, energy metabolism, muscle function, blood flow, DNA repair, randomized controlled trial, placebo, gastrocnemius, satellite cells, supplement, vitamin B3, over-the-counter, chronic leg disease, treatment options, exercise, rehabilitation, patient outcomes, quality of life, cost-effectiveness, healthcare, geriatrics, cardiology --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

A groundbreaking study reveals that the over-the-counter supplement nicotinamide riboside can significantly improve walking ability in patients with peripheral artery disease (PAD). Participants in a six-month trial experienced a remarkable increase in walking distance, while those taking a placebo saw a decline. This affordable and accessible supplement offers new hope for millions living with this debilitating condition, potentially revolutionizing treatment options. #nicotinamide_riboside #peripheral_artery_disease #PAD #clinical_trial #vitamin_B3 McDermott, M.M., Martens, C.R., Domanchuk, K.J. et al. Nicotinamide riboside for peripheral artery disease: the NICE randomized clinical trial. Nat Commun 15, 5046 (2024). https://doi.org/10.1038/s41467-024-49092-5 nicotinamide riboside, peripheral artery disease, PAD, walking endurance, clinical trial, NAD, energy metabolism, muscle function, blood flow, DNA repair, randomized controlled trial, placebo, gastrocnemius, satellite cells, supplement, vitamin B3, over-the-counter, chronic leg disease, treatment options, exercise, rehabilitation, patient outcomes, quality of life, cost-effectiveness, healthcare, geriatrics, cardiology --- Support this podcast: https://podcasters.spotify.com/pod/show/ralph-turchiano/support

In this illuminating episode of [Series Title], we dive deep into the world of Nicotinamide Adenine Dinucleotide (NAD+) and explore the roles of its related compounds, Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN). These molecules are gaining attention for their potential to enhance cellular health and longevity.Join us as we unravel the science behind NAD+, a crucial coenzyme found in every cell of your body that plays a vital role in energy production, DNA repair, and metabolism. We'll break down the importance of NAD+ in maintaining cellular function and how its levels impact overall health and aging.Our expert panel, including biochemists, gerontologists, and researchers, will explain how NR and NMN, precursors to NAD+, are used to boost NAD+ levels. We'll discuss the latest research on how these compounds might help mitigate age-related decline, support cognitive function, and improve metabolic health.'Through engaging interviews and case studies, we'll explore the potential benefits and limitations of NAD+ supplementation. We'll also address common questions about safety, efficacy, and the best practices for integrating these supplements into your health regimen.Discover the fascinating world of NAD+ and its precursors, and learn how they could play a role in optimizing your health and longevity. Tune in to gain a comprehensive understanding of these powerful molecules and their impact on your well-being.

The longevity research world is exploding right now, it's so exciting and the technology is advancing in leaps and bounds and we are able now to discover faster than ever before thanks to AI and co to test more molecules that can impact human health than ever before in the history of mankind. What would have taken years now takes weeks or months. In this episode I talk to Michael Antonelli CEO and founder of Healthgevity. Michael is a master formulator who has spent decades in the anti-ageing and longevity space learning at the feet of many masters and who is at the forefront of working with companies at the cutting edge in peptide and bioactive ingredient development. All his formulations are science backed with clinical research and I was excited to learn about something of these novel molecules Introduction to Healthgevity and its CEO, Michael Antonelli Overview of Healthgevity's approach: merging clinical research, AI, and medical expertise Exploring the importance of longevity in today's society Michael Antonelli's journey and motivation behind founding Healthgevity The role of cutting-edge science in developing longevity supplements How Healthgevity collaborates with clinical practitioners and doctors Deep dive into Healthgevity's science-backed formulations Examples of specific ingredients and their benefits in promoting longevity The impact of AI in optimizing formulations and personalizing supplementation Addressing common misconceptions about longevity supplements Future prospects and advancements in the longevity industry   BIO   Throughout a career spanning over 17 years, Michael passionately devoted himself to pioneering methods aimed at enhancing longevity, optimizing healthspan, and elevating overall quality of life. His focus revolves around collaborating with leading healthcare professionals, researchers, and other likeminded healthcare leaders to create natural solutions that elevate patient outcomes. Michael utilizes his past experiences that integrates a diverse range of therapies and services, spanning from precision diagnostics to practice management strategies, hormone optimization, nutritional supplements, and leveraging peptides. Previous roles included Chief Innovation Officer, Executive Director, and Business Development for leading companies within the healthcare industry before founding Healthgevity. His expertise extends beyond conventional approaches, emphasizing holistic well-being and personalized care as essential components to any successful medical practice. By championing novel methodologies and innovative technologies, Michal facilitates transformative changes within the healthcare landscape, fostering advancements that positively impact both practitioners and the individuals they serve.  Michael continues to remain dedicated to the pursuit of innovative strategies that enhance health and vitality while reshaping the paradigms of healthcare.   Some of the products mentioned in this podcast:   CARDIO NAD+ Vascular health and aging are the most important health care problem in the world today. Healthy aging requires healthy arteries and a healthy heart. Cardio NAD+ is a state-of-the-art solution which uses the most novel ingredients available to help optimize cardiovascular health. As one of the most important systems in your body, we have designed this combination to be synergistic to the many different areas of cardiovascular health while demonstrating cardioprotective effects including the emerging connection between NAD+ and heart health. Featured Supportive Benefits: Improves net NAD+ status by supporting both its synthesis and limiting its degradation Supports healthy blood pressure Improves vascular aging and endothelial function Supports healthy fibrinolytic activity and clotting function Promotes healthy circulation and blood flow Inhibits platelet & red blood cell aggregation Decreases blood viscosity Supports clinical measures of inflammation Supports healthy blood sugar and insulin levels Inhibits lipid peroxidation Supports healthy lipid metabolism Demonstrated reduction in various independent cardiovascular risk factors   Resolve+ Resolve+ contains numerous compounds that have been found to reduce the inflammatory response by targeting a variety of mechanisms.  Acmella oleracea ("jambu") is sourced from Sardinia, Italy and rich in alkylamides mainly represented by spilanthol. Its flowers are widely used in folk medicine to treat toothache due to tingling, numbness, and local anesthesia caused in the mouth.  Acmella oleracea has been shown to be active in fatty acid amide hydrolase (FAAH) inhibition the enzyme responsible for the degradation of fatty acid amides and cannabinoid type 2 (CB2) activation.  There are almost 100 studies suggesting the supportive potential for anti-inflammatory, antioxidant, and analgesic effects of Acmella. Studies reported in this review confirmed activities of Acmella, postulating that transcription factors of the nuclear factor-κB family (NF-κB) trigger the transcription iNOS and COX-2 and several other pro-inflammatory mediators, such as IL-6, IL-1β, and TNF-α. Curcumin, a natural polyphenolic compound derived from turmeric (Curcuma longa L.), has been well documented to exhibit various health benefits. There have been many claims on the health benefits of curcumin on neurological, cardiovascular, lung, metabolic, and liver function, mainly through its anti-inflammatory and antioxidant properties. Despite its promising potential, the clinical application of curcumin has been limited due to its low bioavailability. To enhance curcumin absorption, we are the first to feature Theracurmin Super® 85X, a proprietary curcumin utilizing the latest technology that transforms standard curcumin into an amorphous structure. Theracurmin Super® 85X uses the latest technology to transform regular curcumin particles into a more bioavailable structure. This is done by splitting curcumin particles' crystal structure amorphous, therefore, making it easily absorbed and bioavailable to maximize its supportive potential. Tetrahydrocurcumin (4-HC) is the key bioactive derivative of curcumin, it's also given credibility as the engine behind all that curcumin brings to the table. With a newfound ability to extract and isolate the compound, research has even seen tetrahydrocurcumin outperform its parent compound in several tests of its capabilities. Researchers have also confirmed that 4-HC attenuated pro-inflammatory indicators like interleukin-1, interleukin-6, TNF-⍺, and prostaglandin E2.  After reviewing the data, we found many advantages to infuse tetrahydrocurcumin as CurcuPrime® stacked with Theracurmin Super® 85X into Resolve+. Quercetin is a well-known studied dietary flavonoid ubiquitously present in various vegetables. Quercetin is known for its antioxidant activity in radical scavenging and anti-allergic properties characterized by stimulation of immune system, antiviral activity, inhibition of histamine release, decrease in pro-inflammatory cytokines, leukotrienes creation, and suppresses interleukin IL-4 production.  Multiple studies have confirmed its supportive potential as an immune modulator and its ability to support a healthy inflammatory response. It can improve the Th1/Th2 balance, and restrain antigen specific IgE antibody formation However, chemical instability, poor water solubility and low bioavailability of quercetin greatly limit its applications which is why a phytosome technology which we feature in resolve is the preferred delivery system to overcome these limitations.  This enhanced form of quercetin has been shown to be as much as 20 times better absorbed than other quercetin options.  Casperome®  boswellia phytosome is a potent extract made from the resin of Boswellia serrata trees and is also referred as Indian frankincense. Boswellia extracts have been demonstrated to be effective in the management of various inflammatory response functions including those that occur in the bowel, joints, bones, respiratory airways and in the brain. The mechanism of action that involves the modulation of the natural inflammatory response both acting on prostanoid synthesis (mPGE2S) and protein degradation (caspases), and transcription factors (Nf-κB).  We have selected Casperome® which is a highly standardized in boswellic acids to match the natural composition of boswellia, formulated with phytosome technology to achieve optimized absorption and has been validated by over 10 human studies. Perilla frutescens is an annual herb belonging to the mint family (Lamiaceae). It is mainly produced in countries like China, Japan, India, Thailand and Korea. Recently, Perilla is gaining more attention because of its medicinal benefits and phytochemical contents. The functional compounds of Perilla Seed Extract are flavonoid Aglycons – polyphenols such as Luteolin, Apigenin, Chrysoeriol, and Rosemarinic Acid. Studies have shown that Perilla seed polyphenols regulate allergic and inflammatory response due to its 5-lipoxygenase inhibitory activity and suppression potential of histamine release from mast cells. AstraGin® is a natural compound derived from the roots of two traditional Chinese herbs: Panax notoginseng and Astragalus membranaceous which contain astragaloside I, II, IV and ginsenoside Rb1. AstraGin® has been shown to provide full-spectrum gut support through enhanced absorption, microbiota and immune cell viability, and supporting a health. AstraGin® has been shown in numerous studies to increase the absorption of peptides, amino acids, fatty acids, vitamins, and phytonutrients by up regulating the absorption specific mRNA and transporters, such as SGLT1, CAT1, and GLUT4. Additionally, AstraGin® was shown to reduce intestinal inflammatory biomarker MPO, the pro-inflammatory cytokines IL-6, IL-17, and IL-1β in ulcerative colitis patients. Prime Gut Health Prime Gut Health was created because the digestive system is the foundation of getting and staying healthy. There are many benefits to an optimal digestive system such as a healthy immune system and the protection against harmful viruses, bacteria, fungi, and yeast. The ingredients selected in Prime Gut Health work together to help restore gut homeostasis and GI barrier function.    There are many benefits to taking Prime Gut Health, including:  Supports healthy GI barrier function*   Helps restore gut homeostasis* Binds and neutralizes bacterial toxins in the gut*  Promotes a healthy immune system and respiratory health* Supports digestive health and gut discomfort*  Increased nutrient absorption*  Supports gut inflammation especially within the intestinal wall*  Promotes a healthier GI environment* Promoted regularity and healthy bowel function*    WHAT MAKES PRIME GUT HEALTH SO IMPACTFUL? ImmunoLin® is the branded ingredient serum-derived bovine immunoglobulin/protein isolate (SBI) with over 40 human studies demonstrating its clinical efficacy in digestive and immune health.   SBI has been shown to be a broad-spectrum modulator of the immune system by targeting excessive or imbalanced immunity.* In addition, ImmunoLin® works by binding, neutralizing, and removing pathogenic bacteria, viruses, and other gut irritants that can lead to inflammation.* It also helps to repair the gut lining and restore gut homeostasis.*   Tributyrin (as CoreBiome®) is a postbiotic and the most important short-chain fatty acid (SCFA) for supporting digestive, gut, immune and gastrointestinal health. CoreBiome® is a unique butyrate formula intended to pass intact through the stomach and small intestine to deliver butyrate right where it's needed—the colon.  CoreBiome® supports: Delivery of butyrate to the colon where it helps maintain the integrity of your intestinal lining* Helps repair the gut lining and restore gut homeostasis*  Tight junctures in the intestinal lining*  Regularity and regulation of a normal inflammatory response* Sporebiotics:  Soil-based probiotics have been touted for their stability, ability to improve digestion, stimulate the immune system, and help maintain a healthy gut microbiota. Bacillus coagulans SNZ 1969®, Bacillus subtilis SNZ 1972 and Bacillus clausii SNZ 1971 are supported with an over 50 year history of use and over 30 human studies covering gut health, gastrointestinal discomfort, immunity against GI tract pathogens, inhibition of food borne pathogens, inhibition of bacteria causing dental carries and gingivitis along with bacterial vaginosis. AstraGin® is a 100% natural compound derived from the roots of two traditional Chinese herbs: Panax notoginseng and Astragalus membranaceous,  containing astragaloside I, II, IV and ginsenoside Rb1. AstraGin® enhances nutrient absorption by up-regulating nutrient transporters, such as CAT1, SGLT1, and FR. AstraGin® restores gut wall integrity by triggering an anti-inflammatory response and activating the mTOR pathway for rapid intestinal stem cell migration and differentiation in the inflamed intestinal mucosal barrier (epithelial cell and tight junction). AstraGin® promotes gut ecosystem homeostasis by the symbiotic effect of restoring gut wall integrity and increasing microbiota-immunity communication.  AstraGin® activates the immune system through the symbiotic effect of improved gut wall integrity and enhanced microbiota-immunity communication. AstraGin® demonstrated in a recent published human clinical trial, to improve upon a number of measurable factors relating to gut health making it an ideal addition into Prime Gut Health.  PrimeTime  Prime Time is a comprehensive blend of 12 key natural ingredients shown to have a role in supporting age management powered by industry leading 10mg's of spermidine per serving.  Prime Time has been formulated with ingredients to mimic fasting and catalyze your body's natural ability to rid itself of aged cells.  Various publications demonstrate the potential this formula will have in your longevity protocols as Prime Time was formulated to support:   Epigenetic aging*  Boosting autophagy and promote cellular renewal*  Fasting* Memory, cognition, and brain health* Cardiovascular health* Beauty from within* Mitochondria*  WHAT MAKES PRIME TIME SO IMPACTFUL? Spermidine Spermidine, a natural polyamine, plays a critical role in molecular and cellular interactions involved in various physiological and functional processes. Spermidine has been shown to modulate aging, suppress the occurrence and severity of age-related diseases, and prolong lifespan.  The concentration of spermidine declines with age, and exogenous spermidine supplementation reverses age- associated adverse changes and supports health span. Given that it interacts with various molecules, spermidine influences aging through diverse mechanisms.  Autophagy is the body's way of cleaning out damaged cells, to regenerate newer, healthier cells and is the main mechanism of spermidine. In addition, spermidine exerts its effects through other mechanisms, including anti-inflammation, histone acetylation reduction, lipid metabolism and regulation of cell growth and signaling pathways. Nicotinamide mononucleotide  Nicotinamide mononucleotide, a naturally occurring molecule present in all species.  NMN is rapidly absorbed and converted to NAD+, which evidence shows declines as we age.  In numerous studies, supplementation has increased NAD+ biosynthesis, suppressed age-related adipose tissue inflammation, enhanced insulin secretion and insulin action, improved mitochondrial function, and improves neuronal function in the brain among much more. Epigallocatechin-3-gallate (EGCG)  Epigallocatechin-3-gallate (EGCG) is the major catechin in green tea.  There is consistency in the literature about the beneficial role of green tea on senescence-related mechanisms, thanks to its scavenging properties against reactive oxygen species (ROS) and reactive nitrogen species (RNS) and its ability to stimulate autophagy  Alpha-ketoglutarate (AKG) Alpha-ketoglutarate (AKG) is a molecule involved in several metabolic and cellular pathways that declines with age. It works as an energy donor, a precursor in amino acid production, and a cellular signaling molecule, and it is a regulator of epigenetic processes.  Dihydroquercetin (Taxifolin)  Dihydroquercetin is a powerful antioxidant of plant origin that can protect cells from the harmful effects of free radicals and protect cell membranes against damage Apigenin Apigenin is a natural bioactive plant polyphenol with antioxidant, anti-inflammatory and immune system boosting properties.  It also helps to support against oxidative stress for better cellular function. Studies have shown that apigenin prevents excessive loss of NAD+ by reducing the amount of circulating CD38, allowing NAD+ stores to remain at higher, more youthful levels. Luteolin Luteolin is a flavonoid naturally found in plants. Flavonoids like luteolin have been found to have beneficial effects on human health by reducing oxidative stress.   Trimethylglycine (TMG) Trimethylglycine (TMG) is an amino acid derivative that occurs in plants and has been shown to support methylation which, in turn, supports the homocysteine levels. Taking TMG along with NMN provides the ideal balance for NAD+ production in the body.  Resveratrol  Resveratrol is part of a group of compounds called polyphenols, which act as antioxidants to protect the body against age-related conditions.The anti-aging mechanisms of resveratrol are mainly modulating oxidative stress, relieving inflammatory reaction, improving mitochondrial function, and regulating apoptosis. Resveratrol is considered for the prevention and support of aging and age-related diseases as it mimics the effects of calorie restriction.  Pterostilbene Pterostilbene is a phenolic compound in the same family as resveratrol and is present in small amounts in a large variety of foods and beverages like blueberries or red wine. Multiple studies confirm pterostilbene's remarkable anti-aging effects. Cell and animal studies have shown that pterostilbene can extend the lifespan of various animal models of human longevity by regulating three major pathways linked to longevity: mammalian target of rapamycin (mTOR), AMP-activated protein kinase (AMPK), and sirtuins Bergamot Bergamot (Citrus bergamia) is a type of citrus fruit native to Italy. It has been shown that bergamot juice exerts antioxidant, cardioprotective properties and antisenescence effects.  AstraGin®  AstraGin® is a natural compound derived from the roots of two traditional Chinese herbs: Panax notoginseng and Astragalus membranaceous. AstraGin® increases the absorption of peptides, amino acids, fatty acids, vitamins, and phytonutrients by up-regulating absorption-specific m RNA and transporters such as SGLT1, CAT1, and GLUT4. Check out all the healthgevity products in our shop.    Personalised Health Optimisation Consulting with Lisa Tamati Lisa offers solution focused coaching sessions to help you find the right answers to your challenges. Topics Lisa can help with:  Lisa is a Genetics Practitioner, Health Optimisation Coach, High Performance and Mindset Coach. She is a qualified Ph360 Epigenetics coach and a clinician with The DNA Company and has done years of research into brain rehabilitation, neurodegenerative diseases and biohacking. She has extensive knowledge on such therapies as hyperbaric oxygen,  intravenous vitamin C, sports performance, functional genomics, Thyroid, Hormones, Cancer and much more. She can assist with all functional medicine testing. Testing Options Comprehensive Thyroid testing DUTCH Hormone testing Adrenal Testing Organic Acid Testing Microbiome Testing Cell Blueprint Testing Epigenetics Testing DNA testing Basic Blood Test analysis Heavy Metals  Nutristat Omega 3 to 6 status and more  Lisa and her functional medicine colleagues in the practice can help you navigate the confusing world of health and medicine . She can also advise on the latest research and where to get help if mainstream medicine hasn't got the answers you are searching for whatever the  challenge you are facing from cancer to gut issues, from depression and anxiety, weight loss issues, from head injuries to burn out to hormone optimisation to the latest in longevity science. Book your consultation with Lisa    Join our Patron program and support the show Pushing the Limits' has been free to air for over 8 years. Providing leading edge information to anyone who needs it. But we need help on our mission.  Please join our patron community and get exclusive member benefits (more to roll out later this year) and support this educational platform for the price of a coffee or two You can join by going to  Lisa's Patron Community Or if you just want to support Lisa with a "coffee" go to  https://www.buymeacoffee.com/LisaT to donate $3   Lisa's Anti-Aging and Longevity Supplements  Lisa has spent years curating a very specialized range of exclusive longevity, health optimizing supplements from leading scientists, researchers and companies all around the world.  This is an unprecedented collection. The stuff Lisa wanted for her family but couldn't get in NZ that's what it's in her range. Lisa is constantly researching and interviewing the top scientists and researchers in the world to get you the best cutting edge supplements to optimize your life.   Subscribe to our popular Youtube channel  with over 600 videos, millions of views, a number of full length documentaries, and much more. You don't want to miss out on all the great content on our Lisa's youtube channel. Youtube   Order Lisa's Books Lisa has published 5 books: Running Hot, Running to Extremes, Relentless, What your oncologist isn't telling you and her latest "Thriving on the Edge"  Check them all out at  https://shop.lisatamati.com/collections/books   Perfect Amino Supplement by Dr David Minkoff Introducing PerfectAmino PerfectAmino is an amino acid supplement that is 99% utilized by the body to make protein. PerfectAmino is 3-6x the protein of other sources with almost no calories. 100% vegan and non-GMO. The coated PerfectAmino tablets are a slightly different shape and have a natural, non-GMO, certified organic vegan coating on them so they will glide down your throat easily. Fully absorbed within 20-30 minutes! No other form of protein comes close to PerfectAminos Listen to the episode with Dr Minkoff here:    Use code "tamati" at checkout to get a 10% discount on any of their devices.   Red Light Therapy: Lisa is a huge fan of Red Light Therapy and runs a Hyperbaric and Red Light Therapy clinic. If you are wanting to get the best products try Flexbeam: A wearable Red Light Device https://recharge.health/product/flexbeam-aff/?ref=A9svb6YLz79r38   Or Try Vielights' advanced Photobiomodulation Devices Vielight brain photobiomodulation devices combine electrical engineering and neuroscience. To find out more about photobiomodulation, current studies underway and already completed and for the devices mentioned in this video go to www.vielight.com and use code “tamati” to get 10% off     Enjoyed This Podcast? If you did, subscribe and share it with your friends! If you enjoyed tuning in, then leave us a review and share this with your family and friends. Have any questions? You can contact my team through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts.  To pushing the limits, Lisa and team

CANCER. It's a scary word. And when it comes to skin cancer, the fear is no different. May is Skin Cancer Awareness Month and this time is dedicated to educating people about skin cancers of all kinds. Did you know that globally, between 2 and 3 million cases of non-melanoma skin cancers are diagnosed each year? That's a staggering number, and it means that the chances of being diagnosed with skin cancer are higher than you might think. Be sure to listen to this week's podcast episode featuring Dr. Emily Ruiz, where we talk about non-melanoma skin cancers, tips for preventing skin cancer, and available treatment options. Key Takeaways: - Skin cancer is the most common type of cancer in the world, with basal cell carcinoma and squamous cell carcinoma being the most prevalent forms. - Sun protection is crucial in preventing skin cancer, including wearing protective clothing, using sunscreen, and avoiding midday sun exposure. - The Skin Cancer Champions online community provides support and resources for patients with skin cancer, including information on treatment options and connecting with others. - Other prevention methods include taking nicotinamide supplements and using chemo creams to remove damaged skin. - Early detection and treatment of skin cancer is important for better outcomes, and regular check-ups with a dermatologist are recommended for high-risk individuals. In This Episode: (6:50) Understanding the Different Types of Skin Cancer (9:50) How Do You Get Skin Cancer (11:48) Prevention Methods for Skin Cancer (20:00) Skin Cancer Champions ( 25:22) Nicotinamide   (30:30) Tips for People who have been Diagnosed with Skin Cancer Get Dr. Mina's free PDF on How to create Healthy Skin Habits here. Download the free eBook 'Skincare Myths Busted' here. Emily Ruiz, MD, MPH, is an Associate Physician at the Mohs and Dermatologic Surgery Center at Dana-Farber/Brigham and Women's Cancer Center, an Associate Professor in Dermatology at Harvard Medical School, Director of the High-Risk Skin Cancer Clinic at Dana Farber/Brigham and Women's Hospital, and Program Director of the Micrographic Surgery and Dermatologic Oncology Fellowship. Dr. Ruiz received her undergraduate degree from Duke University, medical degree from New York University School of Medicine, and Master of Public Health Degree from Harvard School of Public Health. She completed an internship in internal medicine at New York University School of Medicine, dermatology residency at Albert Einstein College of Medicine, and fellowship in Micrographic Surgery and Dermatologic Oncology at Brigham and Women's Hospital. Skin Cancer Champions is an online forum for those diagnosed with non-melanoma skin cancers. It's a place where you can find accurate information, connect with others who are on a similar journey, and feel supported every step of the way.  Follow Dr. Mina here:-  https://instagram.com/drminaskin https://www.facebook.com/drminaskin https://www.youtube.com/@drminaskin For more great skin care tips, subscribe to The Skin Real Podcast or visit www.theskinreal.com Baucom & Mina Derm Surgery, LLC Email - scheduling@atlantadermsurgery.com  Contact - (404) 844-0496 Instagram - https://www.instagram.com/baucomminamd/ Thanks for listening! The content of this podcast is for entertainment, educational, and informational purposes and does not constitute formal medical advice.

How do two common supplements stack up against glaucoma, the leading cause of irreversible vision loss in the world?

Nicotinamide mononucleotide is a molecule that is produced naturally in the human body. NMN plays a key role in cellular energy production and DNA repair. NMN is derived from ribose, nicotinamide, nicotinamide riboside and niacin. In addition, a number of our bodies' enzymes use NMN to generate nicotinamide adenine dinucleotide (NAD). NMN is a key molecule for biohacking, as it contributes to improving the body's health and wellness at the cellular level.Relevant links:Buy NMN Here: https://geneticlabsaustralia.com?sca_ref=5628401.fsVlAhEkGm Check Out My Website For Coaching, Recommended Products and Much More:https://www.boostyourbiology.com/ Chapters00:00 Introduction and Personal Journey03:01 Benefits of NMN Supplementation05:00 Dosage and Timing of NMN06:24 Science Behind Boosting NAD Levels08:13 Combining NMN with Other Compounds10:26 Importance of Stable Blood Sugar Levels11:14 Decline of NAD Levels with Age12:31 Mitochondrial Function and Energy13:00 Use Cases and Customer Feedback15:35 Effects of NMN on Testosterone Levels19:45 TGA Approval Process21:46 Ensuring High Quality NMN22:13 Product Launch and Considerations23:12 Customer Demand and Product Prioritization25:16 International Distribution26:46 Strict Quality Control in Australia26:54 Popular Products: NMN and Berberine28:09 Upcoming Products: Fisetin and Urolithin A29:16 Reasons for Purchasing NMN30:11 Proper Storage of NMN31:16 Medication Interactions32:50 Dosage Recommendations for NMN34:10 Combining NMN with Polyphenol-Rich Foods35:37 Aging is Negotiable36:03 Natural Sources of NMN37:11 Coffee and NAD Levels38:21 Moderate Coffee Consumption39:13 Alcohol and NAD Levels40:09 NMN for Athletic Performance41:29 NMN and Endurance42:15 Discussion on Coffee and NMN42:25 Conclusion and Contact InformationDisclaimer:The information provided in this podcast episode is for entertainment purposes and is NOT MEDICAL ADVICE. The products presented and discussed in this podcast are explicitly only relevant to those who reside in the US. The statements and discussions held within this episode, are NOT approved by the TGA. If you have any questions about your health, contact a medical professional. This content is strictly the opinions of Lucas Aoun and is for informational and entertainment purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult with their doctors or qualified health professionals regarding specific health questions. Neither Lucas Aoun nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this content. All consumers of this content especially taking prescription or over-the-counter medications should consult their physician before beginning any nutritional, supplement or lifestyle program. Hosted on Acast. See acast.com/privacy for more information.

In this episode, we dive deep into the fascinating world of fasting with Dr. Chris Rhodes, the co-founder and CEO of Mimio Health. Dr. Rhodes shares insights into the transformative power of fasting and sheds light on the research behind calorie restriction, offering listeners a glimpse into the potential keys to a healthier and longer live. We also explore the concept of fasting mimicking, the breakdown of mTOR vs AMPK, and the powerful ingredients that make Mimio a unique and effective tool in the pursuit of health optimization.Dr. Chris Rhodes is the co-founder and CEO of Mimio Health. He has a PhD in nutrition and has always been fascinated by how we eat affects our health and longevity. Inspired by the power of fasting to enhance lifespan, he spent years researching the human body's response to a 36 hour fast and how it could unlock our built-in longevity bio-programs.Mimio is a biomimetic supplement, derived from bioidentical molecules to the most powerful metabolites produced by our own bodies during a prolonged 36-hour fast, clinically shown to support a wide range of health benefits including enhanced energy, mood, memory and cognition, metabolism, balance to dietary inflammation, and healthy aging.SHOW NOTES:0:53 Welcome to the show!1:44 Dr. Chris Rhodes' Bio2:45 Welcome him to the podcast!3:28 About Mimio4:03 Dr. Chris' background4:54 Fasting for Longevity & Healthspan6:4 Research on Caloric Restriction10:16 Why is mimicking fasting helpful?11:28 His experience with fasting14:44 Longevity & Social Connection14:39 mTOR vs AMPK17:00 Rapamycin: Mechanism of Action18:58 Hormetic Stress & AMP-Kinase20:45 Mimio's Ingredient Sourcing23:59 C.Elegans for Life Extension25:10 *Filter Optix*27:48 The Biomimetic Approach28:28 Mimio Key Ingredients30:47 Nicotinamide & NAD33:45 Dosing structure of Mimio36:30 *Magnesium Breakthrough*38:18 What is Spermidine?43:18 OEA (Oleic Acid)45:29 Optimal duration for fasting47:55 PEA Fatty Acids52:18 Biological Age Testing54:29 Best practices for Mimio57:01 His final piece of advice59:55 Thanks for tuning in!RESOURCES:Website: www.MimioHealth.com - Save 20% with code BHBABES20IG: @mimiohealthIG: @thatnutritiondrFilter Optix Blue-Blocking Glasses: filterpoptix.com/biohackerbabes - code: BIOHACKERBABES to save 15% offMagnesium Breakthrough: Bioptimizers.com/biohackerbabes - code: biohackerbabes10Support this podcast at — https://redcircle.com/biohacker-babes-podcast/donationsAdvertising Inquiries: https://redcircle.com/brands

Nicotinamide mononucleotide (NMN) is often touted as the frontier of anti-aging supplements, promising not just more years of life, but better quality ones.  With bold claims of enhancing lifespan and slowing down aging, to improving physical performance, body composition, and brain health, NMN has captured the attention of both consumers and scientists. But how much truth is there to these claims?  In this episode, I'll explore the molecule NMN, its benefits, the research supporting it, and whether or not it stands up to the hype.  Whether you're a skeptic or a hopeful believer in the search for the fountain of youth, listen to this podcast to learn about the potential of NMN supplements. Timestamps: 0:00 - Please leave a review of the show wherever you listen to podcasts and make sure to subscribe! 2:19 - What is NMN and Why Is It Important? 5:31 - What Does Current Research Say About NMN? 9:52 - Can NMN Really Improve Your Physical Performance and Body Composition? 12:12 - Legion One-on-One Coaching: https://www.muscleforlife.show/vip 13:53 - Is NMN Anti-Aging? Can NMN Supplements Stop or Reverse Aging? 16:57 - Do NMN Supplements Improve Cognition and Brain Health? 21:15 - Are NMN Supplements Worth the Hype? Mentioned on the Show: Legion One-on-One Coaching: https://www.muscleforlife.show/vip

Thousands of Australians see a chiropractor for relief from back pain, headaches or stiffness.There has been a level of controversy surrounding the profession since its inception in the 19th century.But looking beyond the field's storied history, where does the evidence stand now on chiropractic?Got a health question? Shoot us a line @ABCHealth on Instagram, or send a voice memo to thatrash@abc.net.au. We'd love to hear from you!Looking for COVID-19 updates? Don't panic, they've moved over to The Health ReportReferences: Evidence-Based Practice and Chiropractic CareBenefits and harms of spinal manipulative therapy for the treatment of chronic low back pain: systematic review and meta-analysis of randomised controlled trialsAnatomical Sciences in Chiropractic Education: A Survey of Chiropractic Programs in AustraliaA Phase 3 Randomised Trial of Nicotinamide for Skin-Cancer Chemoprevention

Dr. Marc Grossman has been looking into NMN - Nicotinamide Mononucleotide - which is considered to be an anti-aging supplement. Can NMN reverse aging? NMN is a NAD (Nicotinamide adenine dinucleotide) precursor. Studies are starting to show that NMN may increase energy, improve cognitive function, and boost metabolism. It appears to have benefits on the cellular level.Nicotinamide Mononucleotide (NMN) is available on the website, or should be available soon.Dr. Marc Grossman is a Holistic Optometrist and Acupuncturist. Check out  https://www.naturaleyecare.com/ to find the supplements described in this episode and a wealth of vision knowledge.

Here Dr Seranova talks about the supplements she takes, and a couple that she does not. Also sleeping and a hack for getting better deep sleep. The new brain supplement that Dr Seranova talks about is now available. Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK.

Here Dr Seranova talks about her diet and exercise and how she thinks about these. Some links are affiliate links so we will earn a commission when they are used to purchase products. Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK.

On this episode of the Zenhard Podcast Jared and Tomas sits down with Jason Yerrington, owner and operator of Ohana Academy in San Antonio TX, and we explore the world of Jiujitsu and how it pertains to mindset. We touch on multiple subjects ranging from Winning World Championships, and surviving cancer via a juice cleanse. You are not going to want to miss this NAD- ⁠https://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide Gordan Ryan https://en.wikipedia.org/wiki/Gordon_Ryan Mikey Musumeci https://en.wikipedia.org/wiki/Mikey_Musumeci

Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK.

Here Dr Seranova answers some questions on the paper from the first interview (https://youtu.be/fsuhtgKUZRg). Particular topics we discuss, mitochondria fragmentation, de novo pathway in neurons, difference between NR & NMN. Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK.

Here Dr Seranova talks through her latest paper on the impact of NAD precursors (NR & NMN) on autophagy in human neuron Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK.

On this episode of the Zenhard Podcast Jared sits down  with Jerry Rodriguez, owner and operator of Body Concepts Med Spa in San Antonio TX, and we explore the world of Biohacking. How the use of peptides and designer drugs can affect your health and your wellbeing. We also go over Longevity and how Biohacking plays a role in the new wellness. We also touch on the entrepreneurial spirit, and how that drive impacts our lives.  NAD- https://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide NMN-https://en.wikipedia.org/wiki/Nicotinamide_mononucleotide Ipamorelin - https://en.wikipedia.org/wiki/Ipamorelin HRV - https://my.clevelandclinic.org/health/symptoms/21773-heart-rate-variability-hrv Whoop - https://www.whoop.com/us/en/ EMF - NIEHS on EMF

HEALTH NEWS   ·         Blueberries could help protect against metabolic syndrome effects ·         Nicotinamide riboside prevents hearing loss progression in mice ·         6+ hours/day of sedentary leisure time linked to doubling in fibroids risk  ·         Sit all day? Periodic squatting exercises may help preserve your brain power ·         Lycopene, lutein supplements show skin protection from within against UV radiation  ·         Bee propolis has 9 surprising health benefits

I'm joined by Dr. Chris Rhodes from Mimio, where we embark on a fascinating exploration into the intricacies of fasting. Discover how Mimio Health has ingeniously crafted a supplement that awakens fasting pathways, all without the necessity of adhering to strict dietary constraints.   Our discussion spans a multitude of topics, including the myriad advantages of fasting, how Mimio facilitates the attainment of these fasting benefits, the unique ingredients that comprise Mimio's formula, the sustainability aspect of supplements, and an array of other captivating insights. I talk about:  06:10 - Importance of cellular health and its impact on future disease 12:50 - Mimio and the holistic approach to longevity 19:30 - Longevity research and the role of fasting 22:30 - Challenges and considerations surrounding fasting recommendations 29:40 - Fasting-like molecules extend lifespan in model organisms 37:40 - Nicotinamide and spermidine for holistic health benefits 48:20 - Unique formulation and bioavailability of Mimio 52:35 - Timing and usage of Mimio for maximum benefits 56:05 - Consistency and benefits of lifelong Mimio use 1:07:00 - The need for more research in supplement formulations   Sponsors: Try BiOptimizers products (including magnesium, sleep breakthrough powder and digestive enzymes) and use my discount code BIOHACKINGBRITTANY for 10% off! Try AG1 and get a FREE 1-year supply of Vitamin D AND 5 free AG1 Travel Packs with your first purchase.   Resources: Try my Hormone Balancing Chocolate recipe! It's delicious and your body and hormones will thank you. My Ebb and Flow Cycle Guide solves all your hormone problems. Confused on what to eat and do during each phase of your cycle? Download it now for all the answers on cycle syncing and hormone balancing.  Visit Mimio's website and use my discount code BIOHACKINGBRITTANY   Let's Connect: Instagram, TikTok, Facebook Shop my favorite health products Listen on Spotify, Apple Podcasts, Google Podcasts

Discover the secret to youthful, radiant skin as we unpack our newest revolutionary product, Amplifying Essence, with Young Goose co-founder Anastasia. We reveal the synergy between internal cellular health and topical skincare, and how this harmony is embodied in Amplifying Essence.Welcome to another episode of the Biohacking Beauty podcast brought to you by Young Goose Skincare! In this episode, host Amitay Eshel, the CEO of Young Goose, is joined by Anastasia, Young Goose co-founder and the mastermind behind Young Goose's revolutionary newest product, Amplifying Essence. As we all strive for radiant, healthy skin, it's vital to understand the science behind the skincare products we use. In this episode, we discuss the key ingredients and benefits of the Amplifying Essence. These include Aerobic Complex, NAD+ Precursor Nicotinamide, Extremolyte Ection, and Jojoba Milk. The aerobic complex stimulates oxygen uptake in the skin, restoring its youthful processes and rebuilding its function. The NAD boosting properties of Nicotinamide improve the skin's cellular health, offering visible results. Extremolyte Ectoine offers protection against blue light emissions, toxins, and pollution while providing unparalleled hydration benefits.Visit www.younggoose.com and get 20% off your first purchase by using code PODCAST20. If you're a returning customer get 10% off your next purchase by using code PODCAST10. What we discuss:(0:04:07) - Exploring Young Goose's New Amplifying Essence(0:07:12) - What is an Essence(0:15:37) - The Importance of Oxygen in Skincare(0:21:00) - Aerobic Complex in Ampligying Essence(0:23:00) - Nicotinamide as a Precursor to NAD+(0:30:19) - Understanding NAD and Ectoine in Skincare(0:35:46) - Protecting your Skin from Blue Light(0:42:00) - What is Jojoba Milk(0:45:18) - Homeostatic versus Clean SkincareTo learn more about Young Goose:Website: https://www.younggoose.com/Instagram: @young_goose_skincareGet 20% off your first purchase by using code PODCAST20 at www.younggoose.com

Many of the therapies we go through during breast cancer treatment leave us feeling powerless, anxious and crappy. I think that at least some of that anxiety comes from thinking that you don't have a part to play in your treatment but that's not really the case. In this Tuesday Terrain Talk episode, we explore the potential roles of specific supplements like berberine, exogenous ketones, niacinamide, and even the ancient practice of fasting, and how they might support or interact with radiation therapy. With each supplement comes a world of research, potential benefits, and necessary precautions. Are these supplements and practices truly beneficial? Can they enhance the outcomes of radiation therapy or help manage its side effects? Find out the answers and gain insights that bridge the gap between science and actionable knowledge. This episode promises a blend of expertise, cutting-edge research, and actionable insights that might just change how you approach your treatments. If you, or someone you know, is on a journey with breast cancer, this episode is a must-listen. Referred to in this episode: Berberine Anti-cancer mechanisms of berberine- A review Ketogenic diet in the treatment of cancer – Where do we stand? The Role of Nicotinamide in Cancer Chemoprevention and Therapy Metabolic Terrain Institute of Health Practitioner Directory

Nicotinamide adenine dinucleotide, also known as NAD+, is found in every cell in the body and is a coenzyme thats required for generating energy. Intravenous NAD helped Dr Anthony Gustin recover from mold illness but they were uncomfortable, so he created electrically powered NAD patches under his brand ION Layer. You get a slow release of NAD into the bloodstream all day long without the nausea and time requirement of an IV. In this episode we also talk about ketosis and polyunsaturated fatty acids. I ask his thoughts about living in northern latitudes (as he just moved to Oregon), eating seasonally and locally, cold exposure, sugar, homesteading, and more. Dr Anthony Gustin's website: https://dranthonygustin.com/ His podcast: https://itunes.apple.com/WebObjects/MZStore.woa/wa/viewPodcast?id=1341848099 My website: www.matt-blackburn.com Mitolife products: www.mitolife.co Music by George Henner https://georgehenner.bandcamp.com/

Episode 60 - Sam Going Natty :) HGH Peptides, Topical BPC157 & TB500, Meat is now Good for you, Exercise to Lower Anxiety, Nicotinamide Banned, Synthetic Gasoline Show Sponsors www.thetriggeredbrand.com - 15% Off Code - tmt15 www.ultimategymtowel.com - 25% Off Code - tmt25 Test Your Levels Links https://taplink.cc/testyourlevels Youtube Channel - https://www.youtube.com/channel/UCZwSsvti-iVhah5fyfbKwbg Instagram - https://www.instagram.com/testyourlevels/ TikTok - https://www.tiktok.com/@testyourlevels? Sam Stolts Links http://bit.ly/sam-stolt-links Youtube Channel - https://www.youtube.com/channel/UCAOWpCd7-DhAGs8BR3y8_HQ Instagram - https://www.instagram.com/sam.stolt/ TikTok - https://www.tiktok.com/@sam.a.stolt? #MensHealthPodcast #TestosteronePodcast #BodybuildingPodcast

ACD with Jeff Yu! - AAD highlights - Nicotinamide doesn't work in txp pts - Spinosad for scabies Find Jeff Yu on Twitter: @patchtestYu Luke's PDPC course and the Intermountain Derm Society meeting: https://registration.socio.events/e/idspdpc23/promo-codes/ATTENDEE Connect with us! - Web: https://dermaspherepodcast.com/ - Twitter: @DermaspherePC - Instagram: dermaspherepodcast - Facebook: https://www.facebook.com/DermaspherePodcast/ - Check out Luke and Michelle's other podcast, SkinCast! https://healthcare.utah.edu/dermatology/skincast/ Luke and Michelle report no significant conflicts of interest… BUT check out our friends at: - Kikoxp.com(a social platform for doctors to share knowledge) - https://www.levelex.com/games/top-derm (A free dermatology game to learn more dermatology!)

Over the years, I've noticed that people veer away from supplements with complicated-sounding names like nicotinamide riboside (NR). That could be what's kept people in the dark so much about this specific form of vitamin B3. I have to admit that I ignored it for a while, when research papers began emerging several years ago, as well. But the health and fitness benefits are too good to ignore, which is why I decided it was time to write a guide covering what it is, how you might benefit from using it, how much to use, and a few other details about NR. You'll quickly see how it could be helpful for you or someone you know. What is Nicotinamide Riboside (NR)? Nicotinamide Riboside (NR) is a naturally occurring form of vitamin B3. As a precursor to nicotinamide adenine dinucleotide (NAD+), a critical coenzyme found in all living cells, NR maintains cellular energy and supports various biological processes.Canto, C., Menzies, K. J., & Auwerx, J. (2015). NAD+ metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus. Cell metabolism, 22(1), 31-53. https://doi.org/10.1016/j.cmet.2015.05.023 NAD+ is essential for cellular metabolism, DNA repair, and proper functioning of the mitochondria, the "powerhouses of the cell." As we age, our NAD+ levels naturally decline, contributing to various age-related health issues.Verdin, E. (2015). NAD+ in aging, metabolism, and neurodegeneration. Science, 350(6265), 1208-1213. https://doi.org/10.1126/science.aac4854 Research suggests that supplementation with NR may help boost NAD+ levels and combat these effects, improving overall health and well-being.Rajman, L., Chwalek, K., & Sinclair, D. A. (2018). Therapeutic potential of NAD-boosting molecules: the in vivo evidence. Cell metabolism, 27(3), 529-547. https://doi.org/10.1016/j.cmet.2018.02.011 You get trace levels of NR from dietary sources, such as milk, yeast, and some vegetables, but to consume NR at therapeutic levels, you need to supplement with it. Unlike other forms of vitamin B3, such as niacin and nicotinamide, NR maintains a better safety profile and produces fewer side effects.Conze, D., Brenner, C., & Kruger, C. L. (2019). Safety and metabolism of long-term administration of NIAGEN (nicotinamide riboside chloride) in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults. Scientific Reports, 9(1), 9772. https://doi.org/10.1038/s41598-019-46120-z Fitness and Performance Benefits NR supplementation can improve muscle function, increase endurance, and enhance cellular energy production, making it a valuable supplement, especially for aging athletes. Improved Muscle Function One of the key benefits of NR supplementation is its positive impact on muscle function. An animal study found that NR supplementation increased muscle strength and improved exercise capacity. This is believed to result from NR's role in boosting nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme involved in various cellular processes, including energy metabolism and mitochondrial function.Trammell SA, Schmidt MS, Weidemann BJ, et al. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun. 2016;7:12948. doi: 10.1038/ncomms12948 By enhancing NAD+ levels, NR supplementation may help promote muscle health and function, making it a valuable addition to any fitness regimen. Increased Endurance NR supplementation increases endurance performance, too. Another animal study demonstrated that supplementation with NR increased endurance due to the activation of sirtuin 1 (SIRT1), a protein critical in regulating energy metabolism and mitochondrial biogenesis.Cantó, C., Houtkooper, R. H., Pirinen, E., Youn, D. Y., Oosterveer, M. H., Cen, Y., ... & Sauve, A. A. (2012). The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metabolism, 15(6), 838-847.

Nicotinamide mononucleotide (NMN) is very popular in the world of anti-aging. NMN has been shown to raise cellular NAD levels. NAD is an energy molecule we make less of as we age. In theory, raising NAD levels in cells using NAD booster supplements like nicotinamide mononucleotide may help slow aging. NMN is also being investigated as a drug which is why some people feel it may be banned one day.  In this episode, let's review a study showing NMN lowers triglyceride levels - and its drawbacks.  See the video of this episode along with the references. https://youtu.be/sK2OI_w4hLc    Order My Rhabdo Book Rhabdomyolysis is a painful and serious side effect of exercise that you need to know about. Unfortunately, most have never heard of rhabdo and unfortunately have ended up in the hospital because of it. Some people even needed dialysis and still, others have become terrified to exercise again.  Education is the best defense. I've been teaching about rhabdo for over 10 years. If you are in the US, you can order it directly from me. Purchase My Rhabdo Book Order on Amazon   Connect with me: Joe-Cannon.com SupplementClarity.com YouTube   About I have an MS in exercise science and a BS in biology & chemistry. I've been helping people understand dietary supplements for over 20 years using an evidence-based approach and have written several books, including Rhabdo, the first book about exercise-induced rhabdomyolysis.   Disclaimer: Episodes are for information only. I'm NOT a medical doctor. NO medical advice is given or implied. ALWAYS consult your doctor for the best health advice for you. I participate in the Amazon Associates program.

Nicotinamide riboside, a form of niacin (vitamin B3) is a popular antiaging supplement due to its ability to raise cellular NAD levels. In this episode we discuss the study linking nicotinamide riboside to the development of cancer, specifically triple negative breast cancer and the spread of cancer to the brain. Does this supplement cause cancer?   Study: A bioluminescent-based probe for in vivo non-invasive monitoring of nicotinamide riboside uptake reveals a link between metastasis and NAD+ metabolism https://pubmed.ncbi.nlm.nih.gov/36371959/   Updated Nov 18 press release from Univ of Missouri: https://showme.missouri.edu/2022/insight-to-popular-supplements-potential-role-in-cancer-progression/   NR and NMN Videos: NR Videos https://youtu.be/QOqcrtw3CFs https://youtu.be/Rfw1l1xzXms https://youtu.be/JBWXtvn2H6I https://youtu.be/PinhYoGP080   NMN videos https://youtu.be/l28BrR8uBMQ https://youtu.be/agYXZaKLeZw https://youtu.be/sK2OI_w4hLc https://youtu.be/VWgiO_cIl70 https://youtu.be/zmzGs3zAygg https://youtu.be/ef41FY7BLEg https://youtu.be/TFZOGIaTMzc https://youtu.be/5T5sWC4F1Mc =========== Order My Rhabdo Book Rhabdomyolysis is a painful and serious side effect of exercise that you need to know about. Education is the best defense. I've been teaching about rhabdo for over 10 years. If you are in the US, you can order it directly from me.  Purchase My Rhabdo Book Order on Amazon ========================= Connect with me: Joe-Cannon.com SupplementClarity.com YouTube =========== About I have an MS in exercise science and a BS in biology & chemistry. I've been helping people understand dietary supplements for over 20 years using an evidence-based approach and have written several books including Rhabdo, the first book about exercise-induced rhabdomyolysis.  Disclaimer: Episodes are for information only. I'm NOT a medical doctor. NO medical advice is given or implied. ALWAYS consult your doctor for the best health advice for you. I participate in the Amazon Associates program.

Nicotinamide is a B3 vitamin critical for our cells. Recent studies have shown a reduction in the number of pre-cancers and skin cancers in individuals who take this vitamin. Listen in as I chat with Dr. Hari Nadiminti on all things nicotinamide and learn about the vitamin company, Doctamin, which he co-founded to provide high quality supplements to individuals.   @doctor.nadiminti doctamin.com nejm.org/doi/full/10.1056/nejmoa1506197  

The author of one of my all-time favorite books recently released her second book, which was like Christmas coming early for me! Luckily, I had also met her before at an anti-aging conference and we have stayed in touch throughout the years. So I knew I had to Dr. Sandra Kaufmann on The Red Light Report for some amazing conversation about anti-aging and longevity strategies, especially as it relates to supplements and adjuvants —  topics that she is considered a bonafide expert. In her newest book, Aging Solutions, Dr. Kaufmann covers 28 different agents that she has found to be the most efficacious and backed by science, according to her rigorous research. We cover many agents from both of her books along with Dr. Kaufmann's skincare routine and other longevity hacks she as implemented over the years, including red light therapy!Dr. Sandra Kaufmann began her academic career in the field of cellular biology, earning a Master's Degree from the University of Connecticut in Tropical Ecology and Plant Physiology. Turning to medicine, she received her medical Degree at the University of Maryland, and completed a residency and fellowship at Johns Hopkins in the field of pediatric anesthesiology. She has been the Chief of Pediatric Anesthesia at the Joe DiMaggio Children's Hospital for 9 years, a nationally recognized center of excellence.Dr. Kaufmann's avid interest in the science of anti-aging begun many years ago as an intense hobby. Utilizing her knowledge in cell biology, human pharmacology and physiology, this hobby has now become a main focus. The project represents years of non-clinical research leading to the first ever, comprehensive theory of aging. She has now released two books on longevity: The Kaufmann Protocol: Why We Age and How to Stop it, and just recently in 2022, Aging Solutions. This conversation could have easily gone on for hours and hours, as Dr. Kaufmann is a wealth of knowledge in some of my favorite topics and is fun to listen and learn from. I know you will all enjoy learning from her like I did and, if so, I highly recommend you check out BOTH of her books. They are simply amazing resources of anti-aging/longevity information. As always, light up your health! - Dr. Mike Belkowski & Dr. Sandra Kaufmann discuss the following: 3:16 - Her reasoning for jumping into anti-aging and longevity 3:29 - RAADfest - October 2022 in San Diego 8:05 - Supplements vs. adjuvants 9:27 - How people confuse deficiency with longevity 10:57 - Bioavailability and resveratrol  12:15 - Bringing natural remedies back into the light 15:00 - The five basic agents of the Panacea 15:27 - Astaxanthin and its benefits for free radical scavenging 16:33 - The blood-brain barrier 16:53 - Nicotinamide and why it's crucially important for longevity 17:42 - Anti-inflammatories for longevity 18:05 - Glycation 19:15 - Eye health and vision 19:50 - Carnosine eyedrops 21:35 - Eye health and red light therapy 22:38 - Goggles vs. no goggles with red light therapy 25:46 - Supplements and adjuvants she is most excited about 27:10 - Spermidine and how it prevents DNA damage 29:34 - The mitochondrial transition permiability pore 31:36 - Fisetin for longevity 33:22 - Senescent cells (zombie cells) 36:41 - Metformin vs. berberine 38:44 - Glycation and how to defeat it 39:05 - How her diet doesn't affect her good lab results 42:41 - Her anti-aging and longevity regiment 46:06 - Skin health 51:46 - UV exposure to the skin 54:25 - Starting treatments earlier vs. later 59:08 - Micronutrient deficiencies and getting older 1:00:09 - Newfound discoveries - Watch this episode on YouTube - Where to Learn More From & About Dr. Sandra Kaufmann:   Website: KaufmannProtocol.com   Instagram: @KaufmannAntiAging   - Books written by Dr. Sandra Kaufmann:   Aging Solutions (2022)   The Kaufmann Protocol (2017)   - Check out the Kindle version of Red Light Therapy Treatment Protocols eBook, 4th Edition - To learn more about red light therapy and shop for the highest-quality red light therapy products, visit https://www.biolight.shop - Stay up-to-date on social media: Instagram YouTube

Videos : Found on Youtube 1. BlackRock: The Most Evil Business In The World 2. This company owns the world (and it's our fault) – BlackRock   Canadian Study Gives More Evidence Cancer Is A Lifestyle Disease Largely Caused By Food Cancer Control Alberta, Alberta Health Services and University of Calgary, July 22, 2022 Shockingly, worldwide cancer rates are predicted to rise to 1-in-2 women and 1-in-3 men will be diagnosed with some form of cancer. It is so common already, in fact, that it getting cancer is more common than getting married or having a first baby. In reality, one can significantly reduce the likelihood of getting cancer by making lifestyle changes. According to a recently published study out of Canada, the total proportion of cancer rates which can be attributed to lifestyle and environmental factors is quite high, nearing 41%. Regarding the methods used in the study: We estimated summary population attributable risk estimates for 24 risk factors (smoking [both passive and active], overweight and obesity, inadequate physical activity, diet [inadequate fruit and vegetable consumption, inadequate fibre intake, excess red and processed meat consumption, salt consumption, inadequate calcium and vitamin D intake], alcohol, hormones [oral contraceptives and hormone therapy], infections [Epstein-Barr virus, hepatitis B and C viruses, human papillomavirus, Helicobacter pylori], air pollution, natural and artificial ultraviolet radiation, radon and water disinfection by-products) by combining population attributable risk estimates for each of the 24 factors that had been previously estimated.  The list above essentially outlines the wide range of personal choices we know can increase the risk of cancer, mainly pointing out that food causes cancer. Along with exercise, and common avoidable environmental factors, cancer is somewhat preventable. Overall, we estimated that 40.8% of incident cancer cases were attributable to exposure to the 24 factors included in the analysis (Table 2). Tobacco smoking was responsible for the greatest cancer burden, accounting for an estimated 15.7% of all incident cancer cases (2485 cases), followed by physical inactivity and excess body weight, which were responsible for an estimated 7.2% and 4.3% of incident cancer cases, respectively. All other exposures of interest were estimated to be responsible for less than 4.0% of incident cancer cases each. Brain imaging reveals how mindfulness program boosts pain regulation University of Wisconsin-Madison, July 28, 2022 Research at the University of Wisconsin–Madison's Center for Healthy Minds has isolated the changes in pain-related brain activity that follow mindfulness training—pointing a way toward more targeted and precise pain treatment. The study, published in The American Journal of Psychiatry, identified pathways in the brain specific to pain regulation on which activity is altered by the center's eight-week Mindfulness Based Stress Reduction course. These changes were not seen in participants who took a similar course without the mindfulness instruction—important new evidence that the brain changes are due to the mindfulness training itself, according to Joseph Wielgosz. The study is the first to demonstrate pain-related brain changes from a standardized mindfulness course that is widely offered in clinical settings. Around one-third of Americans experience pain-related problems, but common treatments—like medications and invasive procedures—don't work for everyone and, according to Wielgosz, have contributed to an epidemic of addiction to prescription and illicit drugs. Popular with patients and promising in its clinical outcomes, mindfulness training courses like MBSR have taken a central place in the drive for a more effective approach to pain management. By practicing nonjudgmental, “present-centered” awareness of mind and body, participants can learn to respond to pain with less distress and more psychological flexibility—which can ultimately lead to reductions in pain itself. The study also looked at longer-term mindfulness training. Intriguingly, practice on intensive meditation retreats was associated with changes in the neural signature for influences that shape pain indirectly—for example, differences in attention, beliefs and expectations, factors that often increase the perceived levels of distress in non-meditators. These findings help show the potential for mindfulness practice as a lifestyle behavior. Optimistic Women More Likely to Live Past 90 Harvard University, July 23, 2022 Turns out that focusing on the good things really is the recipe for a longer life. A new study from Harvard University, published in the Journal of the American Geriatrics Society, found that higher levels of optimism were positively associated with longer lifespan, with the most optimistic women even living past 90 years old across a variety of racial and ethnic groups. This study included over 150,000 postmenopausal women across a variety of diverse socio-economic and ethnic groups in the United States. These women, aged 50-79, enrolled in the study and were followed for a period of up to 26 years. The results of this study found that the 25% of subjects who were the most optimistic were more likely to have a 5.4% longer lifespan, and a 10% greater likelihood of living beyond 90 years of age compared to the 25% who were the least optimistic. The authors noted that while social structure factors can affect optimism, there is still reason to look on the bright side of life, regardless of these factors, finding that being optimistic is scientifically significant for longer lifespan and overall longevity. According to Hayami Koga, a PhD candidate in the Department of Social and Behavioral Sciences at Harvard T.H. Chan School of Public Health, this new research concluded that “There's value to focusing on positive psychological factors, like optimism, as possible new ways of promoting longevity and healthy aging across diverse groups.” The research from Harvard noted that women who were the most optimistic were 10% more likely to celebrate their 90th birthday than the least optimistic. Based on total demographics, however, the highest vs. lowest optimism quartile in the Women's Health Initiative study is broken down as follows: Overall – Associated with 5.4% longer lifespan White women – 5.1% longer lifespan Black women – 7.6% longer lifespan Hispanic/Latina women – 5.4% longer lifespan Asian women – 1.5% longer lifespan This data shows that Black women have the highest longevity rates (at 7.6%) compared to other demographics specifically when optimism is brought into play. Maintaining a positive outlook and optimism are undeniably large parts of the equation when it comes to living a long life, but there are other factors and lifestyle choices that come into play to ensure not only healthy lifespan, but healthy quality of life. These factors include: A healthy diet —It has always been important to maintain a healthy diet to benefit overall health. While the Mediterranean diet, which emphasizes fruits and vegetables along with healthy fats and whole grains, is known for its health benefits, the Japanese diet is also a great option, with adherence to this diet being associated with a longer lifespan.  Maintaining a healthy weight—Keeping the number on the scale in a healthy range with a combo of diet and exercise is a large aspect of staying healthy. Nutrients—Targeted nutrients can also help support your longevity efforts. These nutrients include: Nicotinamide riboside: A precursor of NAD+, and a form of vitamin B3 that can fight general fatigue, support cellular energy production, and even contribute to anti-aging. Resveratrol: Skip the wine! Resveratrol has potent anti-aging properties, including fighting free radicals and mimicking calorie restricting diets that are key to longevity. Curcumin: The golden spice is knowing for its anti-inflammatory benefits, and with that, its ability to benefit whole-body health. Working to keep your joints and your brain healthy, it's a no brainer that this extract will keep you as young as you feel. Managing stress—Keeping stress at bay is crucial to living a long and healthy life. There's even evidence that managing stress can “un-gray” your hair! And who wouldn't feel optimistic about that? Is Vitamin E Good for PCOS? Nanjing University of Chinese Medicine, July 25, 2022 Can women with polycystic ovary syndrome (PCOS) get pregnant? The answer is: yes…but it can be more challenging than for women without this hormone imbalance condition. For reproductive-age women, the hallmark of PCOS is high androgen levels (the “male” hormone), which can lead to irregular periods and difficulty getting pregnant. But, as daycares full of babies conceived with a little “help” can attest, there are options. A new study published in BMC Women's Health suggests that vitamin E may be helpful for women with PCOS undergoing ovulation induction. According to the study, women with polycystic ovary syndrome undergoing ovulation induction who received vitamin E had lower levels of oxidative stress and required lower doses of human menopausal gonadotropin. In addition to potentially supporting fertility, vitamin E has many other health benefits for women with PCOS: it also helps maintain healthy levels of insulin, triglycerides and LDL. In addition to the BMC Women's Health publication, placebo-controlled studies have shown the benefits of vitamin E for women with PCOS, especially regarding their reproduction and fertility. In the retrospective study from BMC Women's Health, 321 women with PCOS underwent ovulation induction. 105 received 100 mg/d of vitamin E during the follicular phase 106 received 100 mg/d of vitamin E during the luteal phase 110 did not receive vitamin E The results? Those who took vitamin E showed improved resistance to oxidative damage, healthy endometrium thickness, and decreased hMG dosage for healthy ovulation. Total darkness at night is key to success of breast cancer therapy — Tulane study Tulane University, July 25, 2022 Exposure to light at night, which shuts off nighttime production of the hormone melatonin, renders breast cancer completely resistant to tamoxifen, a widely used breast cancer drug, says a new study by Tulane University School of Medicine cancer researchers. The study, “Circadian and Melatonin Disruption by Exposure to Light at Night Drives Intrinsic Resistance to Tamoxifen Therapy in Breast Cancer,” published in the journal Cancer Research, is the first to show that melatonin is vital to the success of tamoxifen in treating breast cancer. “In the first phase of the study, we kept animals in a daily light/dark cycle of 12 hours of light followed by 12 hours of total darkness (melatonin is elevated during the dark phase) for several weeks,” says Hill. “In the second study, we exposed them to the same daily light/dark cycle; however, during the 12 hour dark phase, animals were exposed to extremely dim light at night (melatonin levels are suppressed), roughly equivalent to faint light coming under a door.” Melatonin by itself delayed the formation of tumors and significantly slowed their growth but tamoxifen caused a dramatic regression of tumors in animals with either high nighttime levels of melatonin during complete darkness or those receiving melatonin supplementation during dim light at night exposure. These findings have potentially enormous implications for women being treated with tamoxifen and also regularly exposed to light at night due to sleep problems, working night shifts or exposed to light from computer and TV screens. “High melatonin levels at night put breast cancer cells to ‘sleep' by turning off key growth mechanisms. These cells are vulnerable to tamoxifen. But when the lights are on and melatonin is suppressed, breast cancer cells ‘wake up' and ignore tamoxifen,” Blask says. A Cup of Cranberries a Day Keeps Dementia Away University of East Anglia (UK), July 26, 2022 While aging is inevitable, cognitive decline doesn't have to be. A recent study from the University of East Anglia found some “berry” good news about a way to help support and maintain brain function: cranberry intervention. According to the study, having the equivalent of one cup of fresh cranberries a day can improve memory, neuronal functioning, and vascular health, enhancing blood flow to the brain. And as a sweet bonus, researchers found the red fruit also helps lower LDL (low-density lipoprotein) cholesterol levels, which can build up in the arteries and result in a higher risk for cardiovascular disease and Alzheimer's. “Cranberries are rich in these micronutrients [flavonoids, anthocyanins and proanthocyanidins] and have been recognized for their antioxidant and anti-inflammatory properties,” the authors said. The researchers from the University of East Anglia performed a placebo-controlled study of parallel groups of healthy 50 to 80-year-olds adults to assess the effects of freeze-dried cranberry powder on cognition, brain function and biomarkers for brain cell signaling. The results revealed that taking cranberry extract for 12 weeks improved memory of everyday events (visual episodic memory) and enhanced blood circulation to certain parts of the brain (regional brain perfusion) compared to the placebo group. Better blood flow means essential nutrients such as oxygen and glucose reach areas of the brain associated with memory consolidation and retrieval.

Dr Steve, Dr Scott and Tacie discuss: Nicotinamide to prevent skin cancer Testosterone and quality of life How "terlits" flush Important cholesterol parameters Adult chickenpox Juul vapes banned ... why? Myasthenia gravis The results of Steve's CT scan Please visit: stuff.doctorsteve.com (for all your online shopping needs!) simplyherbals.net  (now with NO !vermect!n!) (JUST KIDDING, Podcast app overlords! Sheesh!) Also don't forget: Cameo.com/weirdmedicine (Book your old pal right now while he's still cheap! "FLUID!") noom.doctorsteve.com (the link still works! Lose weight now before swimsuit season is over!) CHECK US OUT ON PATREON!  ALL NEW CONTENT! Robert Kelly, Mark Normand, mystery guests! Stuff you will never hear on the main show ;-) Learn more about your ad choices. Visit podcastchoices.com/adchoices

Video: 1. Jonathan Pie: The World's End 2. New Rule: OK, Zoomer | Real Time with Bill Maher (HBO) 3. Forget the Great Reset. Embrace the Great Escape. – Zach Weissmueller of ReasonTV (8:20 4. An Imminent Threat from Artificial Intelligence | Aidan Gomez | TEDxOxford   Study finds people who practice intermittent fasting experience less severe complications from COVID-19 Intermountain Healthcare, July 7, 2022 Intermittent fasting has previously shown to have a host of health benefits, including lowering the risk of diabetes and heart disease. Now, researchers from Intermountain Healthcare have found that people who regularly fast are less like to experience severe complications from COVID-19. In a new study published this week in BMJ Nutrition, Prevention & Health, Intermountain researchers found that COVID-19 patients who practiced regular water-only intermittent fasting had lower risk of hospitalization or dying due to the virus than patients who did not. “Intermittent fasting has already shown to lower inflammation and improve cardiovascular health. In this study, we're finding additional benefits when it comes to battling an infection of COVID-19 in patients who have been fasting for decades,” said Benjamin Horne, Ph.D., director of cardiovascular and genetic epidemiology at Intermountain Healthcare. They identified 205 patients who had tested positive for the virus. Of those, 73 said they regularly fasted at least once a month. Researchers found that those who practiced regular fasting had a lower rate of hospitalization or death due to coronavirus. “Intermittent fasting was not associated with whether or not someone tested positive COVID-19, but it was associated with lower severity once patients had tested positive for it,” Dr. Horne said. Fasting reduces inflammation, especially since hyperinflammation is associated with poor COVID-19 outcomes. In addition, after 12 to 14 hours of fasting, the body switches from using glucose in the blood to ketones, including linoleic acid. “There's a pocket on the surface of SARS-CoV-2 that linoleic acid fits into—and can make the virus less able to attach to other cells,” he said. Low CoQ10 levels linked with neurodegeneration: Study University of Tokyo , July 4, 2022 Researchers have found low levels of CoQ10 in people with multiple system atrophy, and suggested supplementation could help. The study , published in JAMA Neurology, shows a link between low levels of blood coenzyme Q10 (CoQ10) and patients with multiple system atrophy (MSA).  The data backs recent hypotheses that CoQ10 deficiency could be linked with development of the neurodegenerative disorder, and that supplementation could be beneficial for MSA sufferers, the team said. The study included 44 Japanese patients with MSA (average age of 64) and 39 Japanese control patients (average age 60). CoQ10 has properties similar to vitamins, but since it is naturally synthesized in the body it is not classed as such. With chemical structure 2,3-dimethoxy-5-methyl-6-decaprenyl-1,4-benzoquinone, it is also known as ubiquinone because of its ‘ubiquitous' distribution throughout the human body. The coenzyme is concentrated in the mitochondria – the ‘power plants' of the cell – and plays a vital role in the production of chemical energy by participating in the production of adenosince triphosphate (ATP), the body's co-called ‘energy currency'. A role beyond the mitochondria is also acknowledged, with CoQ10 acting as a potent antioxidant. The coenzyme plays an important role in preserving levels of vitamin E and vitamin C. They found plasma levels of CoQ10 were significantly lower in MSA patients, regardless of age, sex and Coenzyme Q2, polyprenyltransferase (COQ2) genotype. COQ2 is a protein coding gene which plays a part in the biosynthesis of CoQ10, Dr Tsuji explained. Gardening can cultivate better mental health University of Florida, July 6, 2022 Many longtime gardeners will tell you that the garden is their happy place. New research suggests that many people may indeed reap mental health benefits from working with plants — even if they've never gardened before. In a study published in the journal “PLOS ONE,” University of Florida scientists found that gardening activities lowered stress, anxiety and depression in healthy women who attended twice-weekly gardening classes. None of study participants had gardened before. Our study shows that healthy people can also experience a boost in mental wellbeing through gardening,” said Charles Guy, principal investigator on the study and a professor emeritus in the UF/IFAS environmental horticulture department. Thirty-two women between the ages of 26 and 49 completed the study. All were in good health, which for this experiment meant screening for factors such as chronic health conditions, tobacco use and drug abuse, and having been prescribed medications for anxiety or depression. Half of the participants were assigned to gardening sessions, while the other half were assigned to art-making sessions. Both groups met twice a week for a total eight times. The art group served as a point of comparison with the gardening group. “Both gardening and art activities involve learning, planning, creativity and physical movement, and they are both used therapeutically in medical settings. This makes them more comparable, scientifically speaking, than, for example, gardening and bowling or gardening and reading,” Guy explained. Given the relatively small number of participants and the length of the study, the researchers were still able to demonstrate evidence of what medical clinicians would call the dosage effects of gardening — that is, how much gardening someone has to do to see improvements in mental health. Vitamin B3 reduces the risk of skin cancer University of Sydney, July 5, 2022 Research published in the New England Journal of Medicine offers new hope to those at high risk of developing the most common types of skin cancer. The study found that a form of vitamin B3 significantly decreased the chance of high-risk patients developing non-melanoma skin cancer. Nicotinamide, the active form of vitamin B3, was found to reduce the rate of non-melanoma skin cancer by 23 percent. Commonly available in over-the-counter supplements, it has been found to be very well tolerated without unfavorable side effects. 12-month study points to reduced skin cancer risk with vitamin B3 Lab and animal studies have already shown nicotinamide to hold promise in preventing skin cancers, particularly the most common, non-melanoma variety that are the subject of this latest human study. But even though it was suspected that taking vitamin B3 could reduce skin cancer risk, the results were surprisingly dramatic. The 12-month study involved 386 healthy subjects, all with a history of at least two non-melanoma skin cancers over the past five years, making them at risk for further skin cancers. Subjects were assigned to one of two groups: one receiving 500 mg of nicotinamide twice-daily and the other receiving only a placebo. After 12 months, the rate of new non-melanoma skin cancers was reduced by 23 percent in those receiving the nicotinamide supplement compared to subjects receiving the placebo. It is unusual for a single, natural change to have such a significant impact. An Avocado A Day Helps Keep Bad Cholesterol At Bay Penn State University, July 7, 2022 An avocado a day helps keep bad cholesterol away, a new study reveals. Researchers from Penn State have found that eating an avocado daily for six months decreased unhealthy cholesterol levels. The “healthy” fats in avocados also had no negative effect on a person's belly fat or waist circumference, though it didn't lead to any weight loss either. Previous studies have pointed to the benefits of eating avocados for losing weight, but the current study  is the largest to date that looks at multiple health effects of avocados. “While the avocados did not affect belly fat or weight gain, the study still provides evidence that avocados can be a beneficial addition to a well-balanced diet,” says Penny Kris-Etherton, an Evan Pugh University Professor of Nutritional Sciences at Penn State, in a university release. “Incorporating an avocado per day in this study did not cause weight gain and also caused a slight decrease in LDL cholesterol, which are all important findings for better health.” Doing good deeds helps socially anxious people relax Simon Fraser University (Canada) July 1, 2022  Being busy with acts of kindness can help people who suffer from social anxiety to mingle more easily. This is the opinion of Canadian researchers Jennifer Trew of Simon Fraser University and Lynn Alden of the University of British Columbia, in a study published in Springer's journal Motivation and Emotion. Sufferers from social anxiety are more than just a little shy. Dealings with others might make them feel so threatened or anxious that they often actively avoid socializing. Although this protects them from angst and possible embarrassment, they lose out on the support and intimacy gained from having relationships with others. They have fewer friends, feel insecure when interacting with others, and often do not experience emotional intimacy even in close relationships. Performing acts of kindness to the benefit of others is known to increase happiness and may lead to positive interactions and perceptions of the world at large. The present study investigated if, over time, the pro-social nature of kindness changes the level of anxiety that socially anxious people experienced while interacting with others, and helped them to engage more easily. It extends previous findings by Alden and Trew about the value that doing good deeds holds to socially anxious people. Undergraduate students who experience high levels of social anxiety were enrolled in the study. The 115 participants were randomly assigned into three groups for the four-week intervention period. One group performed acts of kindness, such as doing a roommate's dishes, mowing a neighbour's lawn, or donating to a charity. The second group was only exposed to social interactions and was not asked to engage in such deeds, while the third group participated in no specific intervention and simply recorded what happened each day. A greater overall reduction in patients' desire to avoid social situations was found among the group who actively lent a helping hand. The findings therefore support the value of acts of kindness as an avoidance reduction strategy. It helps to counter feelings of possible rejection and temporary levels of anxiety and distress. It also does so faster than was the case for the participants who were merely exposed to social interactions without engaging in good deeds.

It's incredible how you can have a conversation with someone that's almost 2 hours long, and still feel like you could keep talking! Joel Greene is the CEO of VEEP Nutrition, author of The Immunity Code, and one of the original proponents for prioritizing the gut microbiome (to mention just a few of his many accolades). Joel grew up in the projects, raised by a single mom and surrounded by violence. His upbringing made him resilient, fearless, and determined to learn as much as he could about as much as he could! Our conversation is part philosophical and part scientific and some of the many topics that we cover today include how you can train your insulin sensitivity (and why you should), why you should set aside time for stillness every day, and what you can do to keep your muscles young. This episode is filled with powerful insights from start to finish and you'll walk away with a whole new appreciation for your gut microbiome and a whole lot of knowledge about how to live better and age better!Key Points From This Episode:Introducing today's guest, Joel Greene!An overview of the 16 Personalities personality test, and the value of understanding your personality type.The harsh challenges that Joel experienced growing up, and how they have shaped him into the person he is today.The role that God plays in Joel's life.Why Joel prioritizes rest and stillness.Joel explains the correlation between physical health and productivity.Nicotinamide mononucleotide; why Joel takes this supplement first thing in the morning.Joel explains how his Immunity Code diet works, and the benefits of it.Insulin sensitivity; what it is and the importance of training it. Joel's approach to bringing down his cortisol levels.The value of pre-load meals. A new way to think about carbohydrates.How the bacteria in your gut affect your reactions to certain foods.Commonalities versus bio-individualities; Joel's thoughts on the problem of emphasizing the latter.Understanding the gut microbiome.Factors that indicate how your gut microbiome is functioning.Reasons for my imminent move to Uruguay.Supplements that are helpful for managing stress.Muscles that we lose as we age, and how to slow down the aging process.Exploring the first law of thermodynamics in relation to calories.Links Mentioned in Today's Episode:BiOptimizersJoel Greene on InstagramJoel Greene on LinkedInVEEP NutritionThe Immunity CodeAndrés PreschelEnneagram Test16 PersonalitiesKnow Your Physio PodcastSupport the show

Diets high in fiber associated with less antibiotic resistance in gut bacteria United States Department of Agriculture, May 10, 2022 Healthy adults who eat a diverse diet with at least 8-10 grams of soluble fiber a day have fewer antibiotic-resistant microbes in their guts, according to a study published by Agricultural Research Service scientists and their colleagues in mBio. Microbes that have resistance to various commonly used antibiotics such as tetracycline and aminoglycoside are a significant source of risk for people worldwide, with the widely held expectation that the problem of antimicrobial resistance (AMR)—the term that refers to bacteria, viruses, and fungi that are resistant to antibiotics—is likely to worsen throughout the coming decades.  In this study, the researchers were looking for specific associations of the levels of antibiotic resistance genes in the microbes of the human gut with both fiber and animal protein in adult diets. The researchers found regularly eating a diet with higher levels of fiber and lower levels of protein, especially from beef and pork, was significantly correlated with lower levels of antimicrobial resistance genes (ARG) among their gut microbes. Those with the lowest levels of ARG in their gut microbiomes also had a greater abundance of strict anaerobic microbes, which are bacteria that do not thrive when oxygen is present and are a hallmark of a healthy gut with low inflammation. Bacterial species in the family Clostridiaceae were the most numerous anaerobes found. The strongest evidence was for the association of higher amounts of soluble fiber in the diet with lower levels of ARGs. Soluble fiber, as its name suggests, dissolves in water and is the main type of fiber found in grains like barley and oats; legumes like beans, lentils and peas, seeds (like chia seeds) and nuts; and some fruits and vegetables like carrots, berries, artichokes, broccoli and winter squash. Probiotics stop menopause-like bone loss in mice Emory and Georgia State universities, May 6, 2022 Probiotic supplements protected female mice from the loss of bone density that occurs after having their ovaries removed, researchers at Emory University School of Medicine and Georgia State University have shown  The findings suggest that probiotic bacteria may have potential as an inexpensive treatment for post-menopausal osteoporosis. However, clinical evidence that probiotics can have a lasting effect on the mix of bacteria in the body is limited. Emory and Georgia State researchers found that in mice, the loss of estrogen increases gut permeability, which allows bacterial products to activate immune cells in the intestine. In turn, immune cells release signals that break down bone. Probiotics both tighten up the permeability of the gut and dampen inflammatory signals that drive the immune cells, the team found. Researchers led by Pacifici treated female mice twice a week with Lactobacillus rhamnosus GG (LGG), a type of bacteria found in some yogurts, or with a commercially available mix of eight strains of bacteria known as VSL#3. Good nutrition positively affects social development, research shows University of Pennsylvania, May 6, 2022  Proper nutrition during childhood can positively affect a child's social behaviors and development. It's a unique take on a field that often focuses on how poor diet negatively influences early childhood development. For this study, the scientists analyzed a sample of 1,795 3-year-old children from Mauritius, an island off the eastern coast of Africa with a population of about 1.3 million people. They focused on four aspects of physical health related to nutrition and four indicators of social development. Physical health factors included anemia expressed by low hemoglobin levels, reflecting iron deficiency; angular stomatitis revealed by cracked lips and a lack of vitamin B2 and niacin; and insufficient protein intake indicated by thin or sparse hair and hair discoloration.  The researchers considered a child with just one of the quartet as “suffering from nutritional deficits.” However, children with more malnutrition indicators showed more impaired social behavior. Social interactions studied included friendliness, extent of verbalization, active social play and exploratory behavior.  Examining the relationship between these components after the fact, they teased out a neurocognitive link between nutrition and comprehensive social behavior. It's a connection undiscovered to this point. “The bigger message is give children good nutrition early on,” Liu said. “Not only will it enhance cognitive function but, importantly, promote good social behavior,” which is essential to brain development and intelligence. “In the same study,” Raine said, “we've shown that children with positive social behavior, eight years later, they have higher IQs.” Diabetes almost doubles risk of death from COVID University of Aberdeen, May 10, 2022 People with diabetes were almost twice as likely to die with COVID and almost three times as likely to be critically or severely ill compared to those without diabetes. However, the study conducted by researchers from the University of Aberdeen, which reviewed data from hundreds of thousands of people from all over the world, also found that good management of the condition can mitigate against the risks.  Specifically, the collaboration with King's College, London, found that while diabetes presents a significant risk of severe illness and death with COVID, good control of blood sugar in these patients can significantly reduce this risk.  The researchers reviewed findings from 158 studies that included more that 270,000 participants from all over the world to determine how COVID affects people living with diabetes.  Eating nuts linked to lower risk of colon cancer Seoul National University College of Medicine (Korea), May 6, 2022 Eating nuts has been linked to a number of health benefits, such as a reduced risk of obesity, diabetes and heart disease. Now, new findings from South Korea suggest that a nut-rich diet may also reduce a person's risk of colon cancer.  The researchers found a reduction in this risk for both men and women. Eating a serving of nuts three or more times a week appeared to have a big effect on risk. In the study, a serving of nuts was considered to be 15 grams (0.5 ounces). That's a smaller amount than what's considered a serving in the United States (A serving in the U.S. is 28 g, or 1 oz.) Although the researchers included many types of nuts in their analysis, peanuts were the most widely consumed nuts among people in the study. This may be due to the availability of peanuts in South Korea, the researchers said. The researchers found that men who reported eating three or more servings of nuts a week had a 69 percent lower risk of colon cancer than those who reported eating no nuts. Women who ate three or more servings had an 81 percent lower risk than those who ate no nuts, according to the study. Nicotinamide riboside repairs features of Alzheimer's disease NIH's National Institute on Aging, May 6, 2022 Researchers have found that an NAD+ precursor helped mice with features of Alzheimer's disease perform better on learning and memory tests… The brain's usual DNA repair activity is impaired in Alzheimer's disease, leading to inflammation and dysfunction. A compound that the brain needs to regulate DNA repair and other key signalling pathways is known as nicotinamide adenine dinucleotide (NAD+). Because NAD+ declines with age, scientists have wondered whether boosting the level of NAD+ could help ageing brain cells (neurons) to function better. One way to increase the cellular level is by giving an NAD+ precursor compound, such as nicotinamide riboside (NR). NR is a form of vitamin B3. The team found that the NR-treated mice had less DNA damage, lower levels of neuron damage and death, increased production of new neurons, and lower brain inflammation than control mice. Mice who received NR had reduced tau in their brains, too, but amyloid-beta levels were unchanged. The NR-treated mice performed better than control mice on many learning and memory tests, such as a water maze. In addition, NR-treated mice had better muscle strength and endurance than controls. The research team also tested human cells from people with and without Alzheimer's disease. As in the mouse studies, NR decreased DNA damage in the cells from people with Alzheimer's. Videos: 1. Sensational Charge Against Global Pharma Lobby, Government Hints At Vax Lobby Role In W.H.O Report (4:55) 2. ‘Zelensky is a puppet'; Col. Douglas Macgregor upsets Fox host. (2:18) 3. The Clinton & Gates Foundation were brokers for Big Pharma (4:43)

TCA peels for acanthosis nigricans – Allergen alternatives: Rubbers and plants – Fibroblasts and AD – Tacrolimus swish-and-spit – Nicotinamide for NMSC prevention Connect with us! - Web: https://dermaspherepodcast.com/ - Twitter: @DermaspherePC - Instagram: dermaspherepodcast - Facebook: https://www.facebook.com/DermaspherePodcast/ - Check out Luke and Michelle's other podcast, SkinCast! https://healthcare.utah.edu/dermatology/skincast/ Luke and Michelle report no financial conflicts of interest… BUT check out our friends at: Kikoxp.com (a social platform for doctors to share knowledge) https://www.levelex.com/games/top-derm (A free dermatology game to learn more dermatology!)

Nicotinamide riboside shows promise in Parkinson disease trial   Haukeland University Hospital  (Norway), March 7 2022.    The March 1, 2022 issue of Cell Metabolism reported findings from a randomized, double-blind trial that revealed a benefit for nicotinamide riboside (NR, a form of vitamin B3) among men and women with Parkinson disease. Nicotinamide riboside is a precursor of nicotinamide adenine dinucleotide (NAD), a coenzyme involved in metabolism whose levels decline during aging. “A growing body of evidence supports that boosting cellular levels of nicotinamide adenine dinucleotide (NAD) may confer neuroprotective effects in both healthy aging and neurodegeneration,” Brage Brakedal and colleagues wrote. The trial included 30 newly diagnosed Parkinson disease patients who had not received treatment for the disease. Half of the participants received 500 milligrams NR twice daily and the remainder received a daily placebo for thirty days. Upon enrollment and at the end of the study, participants received MRI and PET scans of the brain, and cerebrospinal fluid, skeletal muscle and blood cells were analyzed for metabolites. Gene expression in muscle and blood cells, and serum and cerebrospinal fluid biomarkers of mitochondrial dysfunction and inflammation were also analyzed at these time points.   (NEXT)   GlyNAC supplementation extends life span in mice   Baylor College of Medicine, March 7, 2022   For over two decades, Sekhar has studied natural aging in older humans and aged mice. His work contributes to providing a better understanding of how glutathione deficiency, increased oxidative stress, mitochondrial dysfunction and multiple additional hallmark defects of aging contribute to the aging process and how they can be reversed with GlyNAC supplementation. "Energy is the currency of life and is generated by mitochondria. However, aging is associated with mitochondrial malfunction, and this could affect energy availability. When we discovered that GlyNAC supplementation can correct mitochondrial defects in aging, we asked an important question: Could GlyNAC supplementation from a younger age extend length of life?" said Sekhar. "To answer this question, we worked with healthy, normal laboratory mice."   (NEXT)   Common houseplants can improve air quality indoors   University of Birmingham UK, March 7 2022   Ordinary potted house plants can potentially make a significant contribution to reducing air pollution in homes and offices, according to new research led by the University of Birmingham . During a series of experiments monitoring common houseplants exposed to nitrogen dioxide (NO2) – a common pollutant – researchers calculated that in some conditions, the plants could be able to reduce NO2 by as much as 20 per cent. The researchers tested three houseplants, easy to maintain and not overly expensive to buy. They included Peace lily (Spathiphyllum wallisii), Corn plant (Dracaena fragrans) and fern arum (Zamioculcas zamiifolia). Each plant was put, by itself, into a test chamber containing levels of NO2 comparable to an office situated next to a busy road. Over a period of one hour, the team calculated that all the plants, regardless of species, were able to remove around half the NO2 in the chamber. The performance of the plants was not dependent on the plants' environment, for example whether it was in light or dark conditions, and whether the soil was wet or dry.   (NEXT)   Nuts may help lower teenagers' risk of metabolic syndrome   University of Texas, March 5, 2022   Modest consumption of nuts every day is associated with an improved cardiovascular risk profile among adolescents, a new analysis of a large national database shows. T Adolescents who ate at least 12.9 grams (g) per day of nuts -- the equivalent of eating a small handful three times per week -- had less than half the odds of non-eaters for developing metabolic syndrome. This syndrome is a cluster of clinical features that heightens the risk of early heart disease and type 2 diabetes. "The surprising finding," said the study's lead investigator Roy Kim, MD, MPH, an assistant professor of pediatrics at the University of Texas Southwestern Medical Center, "is that, in spite of what we know about their health benefits, the majority of teens eat no nuts at all on a typical day." More than 75% of all teens reported eating no nuts at all. The researchers discovered that metabolic syndrome risk decreased with each additional gram per day of nut intake, but only up to 50 g/day (about 1.8 ounces), when the benefit tapered off. Kim theorized that at higher intakes, any benefits may have been offset by eating too many calories.   (NEXT)   Garlic sprouted for five days has improved antioxidant potential   Medical News Today, 1 March 2022   "Sprouted" garlic - old garlic bulbs with bright green shoots emerging from the cloves - is considered to be past its prime and usually ends up in the garbage can. Scientists are reporting in ACS' Journal of Agricultural and Food Chemistry that this type of garlic has even more heart-healthy antioxidant activity than its fresher counterparts. Sprouted garlic has received much less attention. When seedlings grow into green plants, they make many new compounds, including those that protect the young plant against pathogens. Kim's group reasoned that the same thing might be happening when green shoots grow from old heads of garlic. Other studies have shown that sprouted beans and grains have increased antioxidant activity, so the team set out to see if the same is true for garlic.   TONIGHT, ON The Progressive Commentary Hour MY GUEST IS, Edward Dowd, Edward Dowd is a consultant for Symphonic Capital, a US and German financial firm analyzing risk management performance for S&P 500 market opportunities, where he advises on market and risk strategies. He is also a former managing director for large cap growth equities at Blackrock -- one of the world's top three corporate and banking asset holders.