Podcasts about Biochemistry

What if the symptoms you've learned to live with are actually your body trying to tell you something? In this episode, I am joined by VJ Hamilton, The Autoimmunity Nutritionist, to explore what can happen when we slowly drift away from optimal health and how we can begin finding our way back. We also dive into nutrient deficiencies, inflammation, gut and cellular health, nervous system regulation, and why rebuilding your health doesn't have to happen all at once.You're going to love this conversation, and you're going to want to share it with everyone you care about who also desires to look and feel their best too!Learn more about VJ Hamilton:VJ Hamilton, also known as The Autoimmunity Nutritionist, is the founder of The Autoimmune Nutrition Clinic and a Registered Nutritionist, specialising in reversing hair loss, particularly alopecia areata, and other autoimmune-related conditions. With a Medical Science degree (BSc) in Biochemistry & Immunology and certification from the Institute for Functional Medicine, VJ combines scientific expertise with lived experience to deliver evidence-based, personalised therapies.After losing significant amounts of hair to alopecia areata in her 20s, alongside battling psoriasis and post-viral chronic fatigue syndrome, VJ rebuilt her health and restored her hair naturally—remaining symptom-free for over nine years. Today, she helps clients worldwide through her signature programmes and her membership, The Root RESET™ Circle, guiding them to address root causes, calm inflammation, and promote healthy, lasting hair growth.VJ's expertise has been featured in Vogue, GQ, Cosmopolitan, and The Telegraph. She also hosts The Autoimmune Reset® Podcast, where she shares practical strategies for hair regrowth, skin health, and immune resilience.Connect with VJ Hamilton:Website: https://theautoimmunitynutritionist.com/Download the The Autoimmunity Recovery Plan: https://vjhamilton.kartra.com/page/TheAutoimmunityRecoveryPlanStep into your Radiance Sanctuary in the Membership https://www.theschoolofradiance.com/membershipFor more resources related to today's episode, click here for the podcast episode page: https://www.theschoolofradiance.com/podcasts Follow Rachel Varga Official on Instagram: https://www.instagram.com/rachelvargaofficial/ —Catch full episodes of The School of Radiance Podcast here on YouTube https://www.youtube.com/@RachelVargaOfficial —Subscribe to the YouTube channel here: https://www.youtube.com/@RachelVargaOfficial —Follow me here:Instagram: https://www.instagram.com/rachelvargaofficial/ Facebook: https://www.instagram.com/rachelvargaofficial/ Website: https://www.theschoolofradiance.com —FREE STUFF: Download my FREE Skincare Checklist, sign up for my FREE 30 minute biohack your way to clear skin and slowing aging training now, and my newsletter for promos and exclusive events just for you! https://www.theschoolofradiance.com/freebiesEveryone gets one FREE call! Book your free 15-minute call with Rachel Varga to see which options will help you achieve your skin radiance goals! https://rachelvarga.as.me/YourPersonalizedRadianceConsultation —Looking for Skincare products, Tutorials, booking YOUR private One-on-One, and the deep dive Radiance Membership?SHOP skincare: https://alwaysradiantskinshop.comBOOK your private One-on-One: https://rachelvarga.as.me/Initialconsultation REGISTER for Tutorials and/or Membership: https://theschoolofradiance.com As a disclaimer, please note that the information shared in this podcast and interview is not to be taken as medical advice, and it's always important to consult with your physician before making any lifestyle changes. Rachel disclaims any responsibility for inaccurate credentials of guests or information used that may cause harm.Thank you for tuning in to this episode of The School of Radiance with Rachel Varga (formerly The Rachel Varga Podcast and The Always Radiant Skin Podcast)!Rachel Vargainfo@theschoolofradiance.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9/16/26, Co-Host Brian Adams Dr. David Gottsegen: diagnosing, treating and living with Parkinson's. Also, the immunizations you and your kids need now. UMass Professors Margaret Stratton (Biochemistry) and Eric Strieter (Chemistry) —their new $1.3 million grant to search for the protein in your brain that makes memory --how your memory in yr brain works. Evolutionary Biologist from the Woods Hole Oceanographic Institute, Carolyn Tepolt, on invasive species and what do about them — turn green crabs into whiskey and delicious sauce? Democracy at a Crossroads: History, Power, and the Fight Ahead: A Conversation with Ken Burns https://movement.vote/register/8ky1p1vt/ with Larry Hott—a preview of their conversation and the Movement Voter Project event this evening.

What if the next battlefield isn't physical, but your brain?In this episode of Mayim Bialik's Breakdown, Dr. James Giordano (Professor Emeritus of Neurology and Biochemistry, Chair Emeritus of the Neuroethics Studies Program at Georgetown University Medical Center, served as the consulting neuroscientist on research into the original cases of Havana Syndrome) explores the rapidly evolving world of neuroscience, cognitive warfare, biowarfare, electromagnetic technologies, consciousness, and the ethical questions shaping the future of humanity.Dr. Giordano examines why he believes the threat of biowarfare deserves far more public attention, revealing examples of biological technologies that could potentially be used to target individuals and discussing how they may influence brain function, physiology, and perception.He also unpacks the history of covert CIA programs like MKUltra and Operation Artichoke, whose objectives included investigating whether people could be involuntarily controlled, hypnotized, or coerced into acting against their own will - including carrying out assassinations.We dive into the science behind electromagnetic frequencies, explaining how electromagnetic energy interacts with neurological systems, how these technologies have become dramatically smaller, more precise, and more portable, and their potential military applications, from disrupting drones and aircraft to crowd-control technologies.Dr. Giordano also explains how sound waves can disorient the nervous system, why symptoms such as headaches and dizziness may vary so widely between individuals, the controversial discussion surrounding microplastics and electrical conductivity, whether visual stimuli can disrupt neurological function, and how Faraday cages may protect against certain electromagnetic energies.Beyond emerging technologies, the discussion explores one of today's biggest questions: Is cognitive warfare already happening through social media algorithms? Dr. Giordano examines how information environments can shape perception, influence decision-making, and potentially become tools of modern conflict.The conversation expands into the frontiers of neuroscience and consciousness, asking whether some individuals possess neurological architectures that enable extraordinary cognitive abilities, how life experiences, trauma, and brain structure influence perception, why entheogens may facilitate profound spiritual experiences, whether neurophysiology can help explain reports of telepathy or remote viewing, and whether quantum processes could play a role in brain function and what those implications might be if they do.Finally, Dr. Giordano tackles the ethics of modern warfare itself: What is truly permissible in war conducted in the name of defense, freedom, or God? How do societies determine who the real enemies are? And why does he believe that when scientists lose their curiosity, they stop being scientists?Whether you're interested in neuroscience, military technology, psychology, consciousness, philosophy, national security, or the future of humanity, this conversation will challenge your assumptions and leave you questioning far more than you expected!For a limited time, get $250 off Cove Pure water filtration at http://www.covepure.com/breakdownEvery self-made person started somewhere. Yours starts free at https://www.shopify.com/breakdown.Go to https://helixsleep.com/breakdown to receive up to 30% off your Helix mattress.Visit https://drinkag1.com/BREAKDOWN and get a FREE AG1 Flavor Sampler and a FREE bottle of Vitamin D3 + K2 in your Welcome Kit with your first AG1 subscription order.Dr. James Giordano's book, Neurotechnology in National Security and Defense: Practical Considerations, Neuroethical Concerns: https://a.co/d/02ohTd4oFollow us on Substack for Exclusive Bonus Content: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://bialikbreakdown.substack.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠BialikBreakdown.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠YouTube.com/mayimbialik⁠⁠⁠See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What does it take to crack the code of protein production and why do some proteins stubbornly refuse to cooperate, despite the best efforts of scientists and engineers? Biotech's ambitions are often limited not by vision, but by the real-world bottlenecks of host cell lines and the unpredictability of post-translational modifications.Nathan Lewis, GRA Eminent Scholar at the Center for Molecular Medicine, Complex Carbohydrate Research Center, and Department of Biochemistry and Molecular Biology at the University of Georgia, has made a career out of asking impossible questions about glycosylation, cell line selection, and the hidden machinery at work inside every productive cell. He's moved beyond academic curiosity—translating discoveries into applications and even launching a company, Augment Biologics, that's taking glycoengineering from theory to practice.Topics discussed:A proximity proteomics approach to identify supporting machinery for challenging-to-express proteins like rituximab (02:36)Findings from expressing the full human secretome in CHO cells, and the correlation between host cell gene expression and protein productivity (05:00)Clarifying when host cell characteristics matter more than the protein construct itself (05:46)Emerging evidence that protein sequence and structure influence glycosylation patterns (contrary to previous dogma) (06:49)Engineering point mutations to precisely tune glycan features for improved therapeutic efficacy (09:25)The vision and activities of Augment Biologics in custom glycosylation control for drug discovery (10:32)The importance and barriers to open data sharing in bioprocessing, and thoughts on overcoming them (11:11)The shifting landscape as technology advances and the need for high-quality, annotated data (13:54)If this got you thinking about the data already sitting in your freezer, and what it would take to actually use it, start here. These four conversations dig into AI-ready data, actionable omics, hybrid-model digital twins, and the cell-engineering biology underneath it all.Episodes 263 - 264: Why AI and Automation Tools Won't Deliver Until Your Lab's Data Is Connected with David HardyEpisodes 173 - 174: Mastering Hybrid Model Digital Twins: From Lab Scale to Commercial Bioprocessing with Krist GernaeyEpisodes 169 - 170: Why Your DNA Is a Terrible Disease Predictor (And How Multi-Omics Changes Everything) with Mo JainEpisodes 77 - 78: Cell Factories Explained: How Synthetic Biology and AI Revolutionize Protein Production with Mauro TorresIf you'd rather follow the glycosylation thread, check Episodes 69 - 70: Glycoanalytics Explained with Róisín O'FlahertyConnect with Nathan Lewis:Website: www.lewislab.uga.edu LinkedIn: www.linkedin.com/in/nathanelewisFree 5-day email course, The CMC Failure Chain: the five recurring CMC mistakes that put your promising program at risk → Get it hereSupport the show

Dormant omics data are a goldmine for CMC innovation waiting to be unlocked. But legacy structures, poor annotation, and spreadsheet chaos hold most biotech teams back from the real breakthroughs.Nathan Lewis, GRA Eminent Scholar at the Center for Molecular Medicine, Complex Carbohydrate Research Center, and Department of Biochemistry and Molecular Biology at the University of Georgia, has a clear message: actionable data is now within reach thanks to hybrid modeling, advanced study design, and AI as a true scientific collaborator.Topics discussed:Rethinking the dogma: controlling protein glycosylation quality from the inside out, not just by bioprocess conditions (03:00)Nathan Lewis's journey into science and bioprocessing, from unexpected college choices to pivotal advances in CHO cell engineering (05:12)The evolution of omics in bioprocessing: why actionable insights, not just big datasets, should be the goal (10:49)Strategic advice for structuring, annotating, and making old and new datasets ready for AI and LLM analysis (17:34)The balance between mechanistic and machine learning models—when each makes sense, and why hybrid modeling is gaining ground (22:20)The current and future role of digital twins in process development and why foundation models and data consortia matter for scalability (26:24)Smart insight: The real revolution isn't in making new data, but in unlocking the value of what already exists. Advances in AI, hybrid modeling, and collaborative standards promise to turn decades-old data into a catalyst for innovation—enabling faster, smarter, and more reliable bioprocess development.If this got you thinking about the data already sitting in your freezer — and what it would take to actually use it — start here. These four dig into AI-ready data, actionable omics, hybrid-model digital twins, and the cell-engineering biology underneath it all.Episodes 263 - 264: Why AI and Automation Tools Won't Deliver Until Your Lab's Data Is Connected with David HardyEpisodes 173 - 174: Mastering Hybrid Model Digital Twins: From Lab Scale to Commercial Bioprocessing with Krist GernaeyEpisodes 169 - 170: Why Your DNA Is a Terrible Disease Predictor (And How Multi-Omics Changes Everything) with Mo JainEpisodes 77 - 78: Cell Factories Explained: How Synthetic Biology and AI Revolutionize Protein Production with Mauro TorresIf you'd rather follow the glycosylation thread, check Episodes 69 - 70: Glycoanalytics Explained with Róisín O'FlahertyConnect with Nathan Lewis:Website: www.lewislab.uga.edu LinkedIn: www.linkedin.com/in/nathanelewisFree 5-day email course, The CMC Failure Chain: the five recurring CMC mistakes that put your promising program at risk → Get it hereSupport the show

ReferencesGuerra,DJ.2026. Unpublished LecturesGenome Biol. 2019; 20: 249.Stem Cell Reports 2015. V 4, Issue 4, p561–568,14 AprilNPJ 2026. Aging. volume 12, Article number: 109Parker and Charles. 1939.We'll Meet Again. Vera Lynnhttps://music.youtube.com/watch?v=UzNxXya5jr0&si=GOTxoaHhnkthYemA

Dr. Jared Rutter, PhD, Professor of Biochemistry at the University of Utah and Howard Hughes Medical Institute Investigator, is a leading expert on mitochondria and metabolism. He explains how mitochondria produce the energy for your cells to work but also how they regulate cell growth and replication and thereby contribute to health and disease. We also discuss how mitochondria are linked to aging, cancer, and other diseases. Our conversation explores your metabolism as the composite of trillions of individual cells and points to new ways to improve health, avoid, and treat diseases. Show notes: https://go.hubermanlab.com/297-jared-rutter Pre-order Protocols: https://protocolsbook.com Thank you to our sponsors AG1: https://drinkag1.com/huberman Joovv: https://joovv.com/huberman BetterHelp: https://betterhelp.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00:00) Jared Rutter (00:02:29) Metabolism, Cells; Aging (00:08:36) Mitochondria, Origin & Cell Complexity (00:13:07) Sponsors: Joovv & BetterHelp (00:15:16) Mitochondria Genome, Inheritance (00:18:18) Mitochondria & Spatial Distribution; Cell-Specific Metabolism (00:25:59) Nutrient Energy, Hormones, Fat Cells (00:31:13) Glucose, ATP Conversion, Pyruvate (00:36:41) Cell Choice: Energy or Growth, Cancer; Virus (00:46:02) Sponsors: AG1 & Eight Sleep (00:48:36) Microbiome, Role of Humans (00:51:44) Molecule Discovery Process, MPC1, MPC2 (00:59:42) Cell Resource Sensing, Fasting, Glucagon, Fat Cells; Neurons, Heart (01:07:03) Cell Resource Allocation, MPC, Heart Failure; Disease (01:11:46) Sponsor: Function (01:13:24) Cell Size vs Fuel Balance, Cell Identity & Disease (01:20:43) MPC Discovery, Genetics, Model Systems (01:24:29) Lactate, Oxygen, Exercise; Energy Prioritization Hierarchy (01:31:32) Cancer, Mutations, Metabolism Changes & Warburg Effect (01:36:18) Cancer Challenges & Therapies (01:43:00) Therapy Combinations, Unique Cancer Mutations & Metabolism (01:48:31) Technology to Visualize Metabolism; Disease, Metabolism & Scents (01:56:34) Excess Energy & Mitochondria, Reactive Oxygen Species (02:01:12) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

ReferencesCancer Genet Cytogenet 1999 Mar;109(2):108-13. Nat Med. 2017 Jun; 23(6): 775–781.Guerra,DJ . 2026.Unpublished LecturesBMC Cancer 2020 volume 20, Article number: 882(2020Genome Biol. 2019; 20: 249.NPJ Aging 2026. volume 12, Article number: 109Anderson/Squire/Wakeman/Howe/Bruford 1972 Yes. Close to the Edge Lp.https://music.youtube.com/playlist?list=OLAK5uy_lYv_TpuiFzrPaTq69e0eJdT1XLZT2wyTU&si=hrvt6TwjEGrQ4Ji3

Bipolar disorder is often misunderstood as emotional volatility, but beneath its surface lies a profound biological complexity involving neurotransmitters, genetics, circadian rhythms, and even cellular energy systems. In this podcast, I explore the scientific roots of manic and depressive episodes, the brain structures affected, and why treatments like lithium and antipsychotics work at the molecular level. Through the lens of biology, we can see bipolar disorder not as a character flaw, but as a deeply physical condition - one that demands empathy...and continued scientific inquiry.

ReferencesStem Cells International 2020. Epigenetic Regulation of Stem Cell Fate https://doi.org/10.1155/2020/1047896Cancer Science   2014.June 105(9)Cancer Cell. 2026. Volume 44, Issue 2, 9 February: 251-253Genome Biol. 2019; 20: 249.Guerra,DJ.2026. Unpublished Lectures.Dobson& Rose..1972. Morning Dew Grateful Dead. 72'https://music.youtube.com/watch?v=jYR3sBmomgQ&si=-PdTMHXhXUfB_ti4

ReferencesBiochim Biophys Acta Mol Basis Dis. 2021 Mar 11;1867(6):166121.Guerra,DJ,2926, Unpublished LecturesKaukonen/Casady 1973. Burgers. Hot Tunahttps://open.spotify.com/album/0NWwuGPSfuj9H0OMUDikws?si=gF9B18EeSeSBvThyJAAFNQ

This CEO is Fighting Parkinson's And Other Neuro-Degenerative Diseases – Meet Gain Therapeutics GANX CEOGuest: Gene Mack, CEO, Gain TherapeuticsGuest's Bio: Gene Mack serves as Chief Executive Officer and President of Gain Therapeutics. He joined the Company in April 2024 and brings 25 years of experience in the life sciences sector spanning clinical research, financing and capital markets, investing, corporate strategy and business development. Prior to joining Gain, Gene was CFO at privately held Imcyse SA between 2021 and 2023. Previous to Imcyse, Gene was CFO at OncoC4, a privately held biotechnology company that spun out of Merck & Co's (MSD) $475 million acquisition of OncoImmune in 2020 where he had also been CFO. Before that, he has held the CFO role for several development- and commercial-stage biopharmaceutical companies, raising over $350 million in IPO and other equity transactions. Prior to his operational experience, Gene covered the biotechnology and life sciences sector as a senior publishing analyst at various investment banks, including Gruntal & Co, Lazard, Mizuho, and HSBC. Gene received both his B.S. in Biochemistry and M.B.A. in Finance from Fordham University.Company: Gain Therapeutics ($GANX)Company Description: Gain Therapeutics, a clinical-stage biotechnology company headquartered in Bethesda focused on developing novel allosteric small molecule therapies for neurodegenerative diseases.Under Gene's leadership, the company is advancing its lead candidate, GT-02287, with recent Phase 1b data presented at AD/PD 2026 demonstrating encouraging biomarker improvements, including reductions in DDC and glucosylsphingosine, as well as durable clinical outcomes through 150 days of treatment in Parkinson's disease.

ReferencesClin Dev Immunol. 2008 Mar 19;2008:416910Front Immunol. 2018 Apr 25:9:883Front Immunol. 2018 Jan 29:9:69Cell Mol Immunol. 2022 May 17;19(7):820–833Guerra,DJ.2026.Unpublished Lipid LecturesVivaldi, A. 1711. Concerto No.11 Op.3 'L'estro Armonico', 3 Balanas, Sinfoniettahttps://youtu.be/Z3ffgvn5XIg?si=fmWr1VaNxhnQZaSZFarrow, JO. 1970. What About Me? QMShttps://open.spotify.com/track/3sLOV0GZxECi1xcRVzSwaS?si=5a7b06abf35146a4

ReferencesSeminars in Cancer Biology2026.V 121. April. : 22-32MDPI Applied Sci. 2024. May.14(11) 4489Guerra,DJ.2026. Unpublished Lectures.Handel,GF. 1711. Lascia ch'io pianga aria from Rinaldohttps://youtu.be/EKo_EmfEPWs?si=kN5-LN8f7hgMAiwVBiber, HIF. 1676. Pasacaglia Violin Sonata https://youtu.be/sgcR183f8gA?si=LezG0WbhNccfHt1T

ReferencesMol Metab. 2021 Apr 20;50:101238Guerra, DJ.2026. Unpublished Lipid LecturesLennon/McCartney. 1968 Penny Lane Beatleshttps://open.spotify.com/track/1h04XMpzGzmAudoI6VHBgA?si=1d1f77be373b4da9Anderson, I.1969 Fat Man Jethro Tullhttps://open.spotify.com/track/5vEzhZ9iwk5XFUHBZuDjfI?si=ab4f6bedb7344873Hunter/Garcia. Wake of the Flood 1973. Grateful Deadhttps://open.spotify.com/album/4wIEQMHtdye4aeSc2FYxI0?si=vIci1F9AS86DMlwSZdDzuQ

ReferencesBMC Research Notes 2021 volume 14, Article number: 315 Guerra,DJ.2026.Unpublished LecturesMozart,WA.1791. Magic Flute aria Papagena duethttps://youtu.be/lP9V7_fevgQ?si=l4txAGL5Y_u3oTrj

ReferencesJ Lipid Res. 2016 Dec 29;58(1):216–225.Nature Communications.2017. volume 8, Article number: 503 Biomolecules 2021, 11(7), 1016.Guerra, DJ.2026. Unpublished Lectures.Stevens, C.1972.The Wind https://music.youtube.com/watch?v=1EjKJuaLZO0&si=UFUbtlH6mr2smFzzHendrix,J.1967. Wind Cries Maryhttps://open.spotify.com/track/5H6Jp0syB5yEPk7SWYdlmk?si=468f3a15830a4a29Leach, D.1965. Catch the Windhttps://open.spotify.com/track/505Pd7CPHoewIE3Io2EpWd?si=e83a43cd0ce34fcfHunter/Garcia.1977.Franklin's Tower Grateful Deadhttps://music.youtube.com/watch?v=55TOIJxKc74&si=6hIiA4v9J-FenCDCSinfield/McDonald.1969. I Talk to the Wind. King Crimsonhttps://music.youtube.com/watch?v=UlKrH07au6E&si=QSTSDYtg82A23b26

The conversation delves into the manipulation of cholesterol definitions and the impact of statins on health. It explores the changing narrative around cholesterol, the influence of big pharma, and the downsides of statins, providing a critical perspective on these topics. The conversation covers topics related to LP Little A, plaque reversal, the thrombotic theory of plaque formation, Alzheimer's and brain health, and blood pressure in relation to insulin resistance. The discussion emphasizes the impact of insulin resistance on plaque formation and the role of metabolism in reversing plaque. Additionally, it delves into the various theories of Alzheimer's and the influence of blood pressure guidelines on drug sales.TakeawaysManipulation of cholesterol definitionsStatins and their impact on health LP Little A is a rehashed version of LDLInsulin resistance is the major cause of plaque in arteriesChapters00:00 Manipulation of Cholesterol Definitions04:00 The Impact of Statins on Health25:39 Understanding LP Little A31:26 Plaque Reversal and Metabolism39:56 Thrombotic Theory of Plaque Formation42:31 Alzheimer's and Brain Health47:20 Blood Pressure and Insulin Resistance

ReferencesNature 2024. 626, pages411–418 Guerra, DJ.2026. Unpublished LecturesSinatra, F 1950-60 Nothing But the Besthttps://open.spotify.com/album/3i67sGIVw8EBlgfSRv3Lj2?si=Iw3QUGyqRQeMUeepLalgMA

ReferencesiScience 2026. Volume 29, Issue 3, 20 March 114859Journal of Advanced Research 2025.77. November 207-219 Guerra,DJ.2026.Unpublished Lectures.Leeuwen, RV.1969. Venus. Shocking Blue. https://youtu.be/dBjWwGYxcnU?si=j9tYgpO7doDZIjalBeethoven LV.1809. Piano Concerto V in E Flat. Op.73https://music.youtube.com/watch?v=3TiYGxOQDYw&si=OFTXHgid_vtrcfMH

ReferencesProtein Cell. 2021 Apr; 12(4): 240–260. Immune Science 2026. Volume 29, Issue 3, 20 March 114859Nature Chemical Biology 2022 volume 18, pages 470–481Guerra,DJ.2026. Unpublished LecturesSimon,P. 1966. Sounds of Silence album S&G.https://music.youtube.com/playlist?list=OLAK5uy_l1zPBX4IytOZWfqrKWceG__uYvGxPSWJ0&si=d4I6kyPmuJb9xhLh

ReferencesJ Lipid Res. 2012 Sep;53(9):1723–1737.Acta Pharm Sin B. 2015 Feb 25;5(2):135–144Semin Immunopathol. 2021 Jul 8;43(4):577–590Guerra,DJ.2026.Unpublished LecturesPage & Plant.1971.Battle of Evermore LZIVhttps://open.spotify.com/track/6KCjY5kHvgWaWcAV6BBzxO?si=4d4ae1f420394d8fSquire/Anderson/Howe.1971. All Good People. YEShttps://open.spotify.com/track/1WVMgdTBBD4kQ5j1IRl0tE?si=c2a5c3ebcb3e4096Schubert,F. 1824. String Quartet 14. in D. Minor. D.810. Death&the Maidenhttps://music.youtube.com/watch?v=NtBqvOM1CuE&si=R7bVLGXzdgVN1H1H

ReferencesAm J Clin Nutr. 1993 Nov;58(5 Suppl):800S-809SProtein Cell. 2021.12.4.249-260J of Experimental and Clinical Cancer Research 2022. V. 41. Paper # 303.Front Genet. 2019 Jun 4;10:472Guerra, DJ.2026.Unpublished Lectures.Kirwan/McVie/Welch/Scarrott.1972.Bare Trees.Fleetwood Mac. https://music.youtube.com/playlist?list=OLAK5uy_nr8AaADiPpe16ybU_hxVTH9k5zG8t2T6A&si=MecWBqZpotwPsKRbSchmelzer. JH. 1664. Romanesca. Violin Sonatae. https://music.youtube.com/playlist?list=OLAK5uy_k8TeNzQczMKnGy8h8DZ5Wgl_JEHxlc-m4&si=0ciYnURqzchC3p7l

GUEST:   https://leecarrollherbalist.com/  https://www.instagram.com/leecarrollherbalist/   MENTIONS:   https://en.wikipedia.org/wiki/Ergothioneine   https://en.wikipedia.org/wiki/Erinacine   https://www.sciencedirect.com/science/article/pii/S0006295223005257   https://en.wikipedia.org/wiki/Beta-glucan   MUSHROOM HOUR:   https://welcometomushroomhour.com   https://www.instagram.com/mushroomhourpodcast   https://tiktok.com/@welcome_to_mushroom_hour   Show Music courtesy of the one and only Chris Peck: https://peckthetowncrier.bandcamp.com/   TOPICS COVERED:   Herbal Medicine Industry   Importance of Ergothioneine   Fungal Receptors in the Human Body   Fungal Archaeology & EthnomycologyGourmet Ape Theory   Fiber & Beta-Glucans   Anti-Oxidants and Protein Turnover   Fungal Lifecycle and Innovation   Fungal Fermented Substrates   Distinguishing Different Mycelium-Based Medicinals   Assessing “Full Spectrum” Claims   Nuclear Magnetic Resonance Imaging   Bitter Molecule Receptors in the Heart   

Send us Fan MailToday we're releasing a new episode from a brand new series called the Boundless Body Radio Heritage Series! I wanted to do something extra special to celebrate 1,000 podcast episodes recorded here at Boundless Body Radio, a milestone that we hit on June 24, 2026!These episodes are actually not new, although they might be new to you! When we first got started back in October, 2020, I was so fortunate that so many incredible people said "YES" to being hosted on the show, however, we didn't have very many listeners at the time!Today, we get thousands of downloads every single month, and are usually included in the top 150 Fitness and Nutrition Podcasts on the Apple Podcast charts!To honor our amazing guests, I will be selecting one of those original episodes and posting them here on for this special series!As I was going through these episodes again, I remembered how valuable these conversations actually were. it was really striking how much the information these experts have shared has born out to be even more accurate several years later.The audio quality of a show was not as good back then as it is now, but I still really hope you enjoy these episodes, and find them relevant and helpful to you today!Cheers, thanks as always for listening, and I really hope you enjoy this episode of the Boundless Body Radio Heritage Series!Dr. Thomas Seyfried is a returning guest on our show! Be sure to check out his first appearance on Boundless Body Radio on episode 60, which one of the most fascinating discussions we've ever had, all about cancer as a metabolic disease! He was also hosted on episode 363 of our podcast.Thomas N. Seyfried received his Ph.D. in Genetics and Biochemistry from the University of Illinois, Urbana, in 1976. He was a Postdoctoral Fellow in the Department of Neurology at the Yale University School of Medicine and then served on the faculty as an Assistant Professor in Neurology. Other awards and honors have come from such diverse organizations as the American Oil Chemists Society, the National Institutes of Health, The American Society for Neurochemistry, the Ketogenic Diet Special Interest Group of the American Epilepsy Society, the Academy of Comprehensive and Complementary Medicine, and the American College of Nutrition.Dr. Seyfried has over 150 peer-reviewed publications and is the author of the book, Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer (Wiley, 1st ed., 2012).Find Dr. Seyfried at-https://foundationformetaboliccancertherapies.com/Movie, coming soon- CANCERREVOLUTION: A Cancer Science Documentary with Dr. Seyfried and former podcast guest Travis Christofferson.Find Boundless Body at-myboundlessbody.comFind Boundless Body at-myboundlessbody.comBook a session with us here! 

Quantum Scientist Patrick Coles Reveals How Tumors Protect Your Mitochondria From Toxic Overload Cancer might not be the enemy your doctor says it is. What if tumors are actually your body's emergency detox system, built on purpose to protect you from something far more dangerous? Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Patrick Coles, Ph.D., Chief Scientist at Normal Computing, where he develops novel computing hardware for AI applications. Previously a Staff Scientist at Los Alamos National Lab, Coles led their near-term quantum computing group and made significant contributions to quantum computing theory. He holds a Ph.D. in Chemical Engineering from UC Berkeley and a Master of Philosophy in Biochemistry from Cambridge, and he's currently developing a new theory for cancer and chronic disease, the subject of this conversation. His rare combination of hard physics and deep biochemistry gives him a radically different lens on one of medicine's most misunderstood diseases. Coles lays out his Toxin Sequestration Theory, a framework that reframes cancer tumors not as malignant accidents but as intentional storage vaults the body builds to sequester toxins, heavy metals, seed oils, mold, and excess glucose, away from healthy tissue and mitochondria. He and Dave connect the dots between this theory and chronic disease, biohacking fundamentals, and why chemotherapy itself behaves as a toxin that can backfire. They dig into oxalates, deuterium, linoleic acid, circadian biology, and the detox protocols that support the body's natural ability to shrink these toxic reservoirs. This conversation challenges the mainstream genetic theory of cancer, explores the metabolic theory popularized by Thomas Seyfried, and lands on a radical, functional medicine-aligned framework for anyone serious about longevity, anti-aging, and human performance. Dave and Coles also break down how sleep optimization, fasting, ketosis, and a carnivore approach to nutrition support the body's detox hierarchy, from fat tissue and the liver to moles, cysts, and eventually tumors themselves. This is essential listening for anyone serious about biohacking, functional medicine, mitochondria health, brain optimization, nootropics, and taking full control of their metabolism and longevity. You'll Learn: Why toxins may be the root cause of Alzheimer's, Parkinson's, autism, and most chronic disease How Toxin Sequestration Theory reinterprets tumors as the body's backup detox organs Why chemotherapy ranks among the most tissue-damaging toxins, and what happens when a tumor bursts The role of oxalates, deuterium, heavy metals, and seed oils in cancer cell hoarding Why moles, cysts, lipomas, and nodules may be minor versions of the same detox response How circadian rhythm, sleep, and light exposure affect the body's toxin excretion cycles What spontaneous tumor regression reveals about lowering your toxic burden Why tracking tumor progression matters no matter which treatment path you choose Thank you to our sponsors! - Download Dave's Free Peptide Guide at daveasprey.com/peptide-guide. - ZenBud | Dave's Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. - Timeline | Visit timeline.com/dave to learn more about Mitopure and get 20% off your first order for a limited time. - Just Thrive | Get a free 90-day supply of Digestive Bitters (a $90 value) when you start a 90-day Just Thrive Probiotic subscription at https://get.justthrivehealth.com/pages/asprey Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: toxin sequestration theory, cancer theory, Patrick Coles, quantum computing scientist, thermodynamic computing, Normal Computing, Los Alamos National Lab, chemotherapy toxicity, oxalates cancer, deuterium toxin, Stephanie Seneff, heavy metal detox, mycotoxins tumors, seed oils cancer, linoleic acid, oleic acid oxidation, lipid peroxidation, glucose toxicity, mitochondria downregulation, genetic theory of cancer, metabolic theory of cancer, Thomas Seyfried, spontaneous tumor regression, backup detox organ, circadian rhythm cancer, mold toxins, forever chemicals, microplastics, bile flow, activated charcoal binders, cholestyramine Resources: • Follow Patrick's Work At: https://www.instagram.com/patrickc_tst/ • Watch Gabby's Podcast At: https://www.youtube.com/@GabbyReece • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:58 – Introducing Patrick Coles 04:08 – Toxin Sequestration Theory 06:26 – Defining a Toxin 14:13 – Cancer as Backup Detox Organ 15:01 – History of the Theory 16:30 – Deuterium and Oxalates 21:31 – Cancer Theories Compared 28:06 – Chemotherapy and Toxic Overload 37:23 – Tiered Toxin Storage System 45:17 – Diet, Light, and Circadian Rhythm 50:39 – Detox Protocols and Binders See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Send us Fan MailThe biology of endogenous cannabinoids & history of cannabinoid-based therapeuticsTOPICS DISCUSSED:Anandamide vs 2-AG: The two major endocannabinoids with a shared arachidonic acid backbone but distinct head groups biological roles.On-demand production: Calcium-dependent enzymes release cannabinoids from membranes in response to neuronal activity patterns.Trafficking: Fatty acid binding proteins and extracellular microvesicles traffic endocannabinoids within and between cells.Adolescent THC: Global receptor activation during circuit wiring may contribute to cannabis use disorder and psychosis vulnerability in susceptible individuals.Enzyme inhibitors: Early FAAH clinical trial halted by off-target toxicity; MAGL inhibitors advancing in phase 2 for anxiety and addiction.Peripheral CB1: Liver receptors regulate metabolism; restricted antagonists aim to reduce weight without central psychiatric risks of the weight loss drug rimonabant.ABOUT THE GUEST: Nephi Stella, PhD is a professor at the University of Washington School of Medicine. He has studied endocannabinoid signaling for more than 25 years, focusing on therapeutic strategies that separate beneficial effects from side effects of cannabinoid-system modulation.Support the showSupport my work:Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.For all the ways you can support my efforts.

If you already know you need to change and somehow still don't, this conversation reveals what's actually running the show — and how to rewrite it. For over a century we were handed one story: your DNA is your destiny, life is survival of the fittest, and more requires struggle. Cell biologist Bruce H. Lipton — bestselling author of The Biology of Belief — spent his career proving it wrong. Cloning genetically identical stem cells into three different environments, he watched them become muscle, bone, and fat based not on their genes but on the world he grew them in. We are, he says, "skin-covered petri dishes," and our thoughts write the chemistry our cells swim in. In this conversation, Bruce H. Lipton and Celinne explore why 95% of your life runs on a subconscious program set before age seven. The three ways to actually rewrite it, and why "survival of the fittest" is a story rather than a law. You'll hear how a lifelong atheist followed his own science into the sacred. And what becomes possible when you stop living the inherited story and start creating from the one that's truly yours. ON THIS EPISODE: 00:00 Hear the synchronicity that brought this conversation together 03:44 Define consciousness the way a biologist actually means it 04:19 Discover the stem-cell experiment that proves environment, not genes, shapes you 09:08 Learn how every thought becomes love chemistry or fear chemistry 14:05 Meet your two minds, and why we were programmed before age seven 20:00 Confront the 95%: how much of your life runs on autopilot 24:53 Explore the art and science of change, and why knowing isn't enough 35:07 Get the three ways to actually rewrite a subconscious program 51:53 Reframe identity itself: "you are not the TV, you're the broadcast" KEY IDEAS: ✨ Genes don't run you — your perception does: Environment, not DNA, decides what a cell becomes, and your thoughts write the chemistry your cells swim in. You're not a victim of your biology; you're its author. ✨ 95% of your life is a program: Only about 5% of your day is conscious creation. The rest runs on subconscious programming installed before age seven, and more than 60% of it is self-limiting. As Bruce puts it, "you are living a different life than you think you are living." ✨ You can't think your way out — you rewrite it: Insight alone doesn't change behavior, which is why knowing isn't enough. Bruce names three ways to reprogram: self-hypnosis in theta, repetition and habituation, and energy psychology for rapid change. ✨ Survival of the fittest is a story, not a law: "Struggle is made up". A Victorian-era idea repeated until it felt like biology. Real evolution runs on consciousness and cooperation, which is why the future belongs to the most conscious. RESOURCES: Bruce H. Lipton, PhD: is an internationally recognized bestselling author and cellular biologist who has spent decades challenging scientific orthodoxy with a revolutionary message: genes don't control our destiny—our beliefs and environment do. As a senior research scientist at Stanford University's School of Medicine, his groundbreaking cloning experiments revealed the biochemical pathways by which the mind controls behavior and genetic activity, presaging today's revolutionary field of epigenetics. Dr. Lipton's research has been published in prestigious scientific journals including Science, Nature, Journal of Cell Biology, Developmental Biology, Biochemistry, and Experimental Cell Research. Translated into over 50 languages and with more than 500,000 copies sold, The Biology of Belief has become a global phenomenon. Bruce was named one of the world's most spiritually influential living people by the United Kingdom's Watkins Journal and received Japan's prestigious 2009 Goi Peace Award in honor of his scientific contribution to world harmony. Website | Facebook | Twitter X Beyond Darwin: How Epigenetics, Quantum Science, and Cooperation Shape Humanity's Future by Bruce H. Lipton, PhD, with Patricia King (BenBella Books, distributed by Simon & Schuster). For over a century, Darwin's "survival of the fittest" — life as competition — has shaped civilization. In Beyond Darwin, Lipton offers a paradigm-shattering synthesis built on three fields unknown to Darwin: epigenetics, quantum physics, and fractal geometry. It's the unified theory of Conscious Evolution, backed by hard science — from survival of the fittest to survival of the most conscious. Releases August 18, 2026. Pre-order the book. Celinne Da Costa is a podcast host, bestselling author, and executive coach for leaders navigating 'I've made it—now what?' She guides them to redesign their next act: more meaningful, more aligned, more fun... and led by their soul's truth. Website | LinkedIn | Substack | Instagram | Facebook

ReferencesArterioscler Thromb Vasc Biol. 2011 Nov 17;32(2):459–466Circulation2024.volume 150, Issue 1, 2 JulyPages 62-79Diabetol Metab Syndr. 2022 Aug 23;14(1):119.Metabolites. 2026 Jul 14;16(7):496.Br J Nutr. 2008 Nov;100(5):947-52Guerra,DJ.2026.Unpublished Lipid LecturesRosinni, G.1829. Guillermo Tell Overaturahttps://music.youtube.com/watch?v=sHQ1Date2v0&si=4vkJfKo6HtXYHMHjClapton/Sharpe. 1967. Tales of Brave Ulysses. Creamhttps://open.spotify.com/track/2mKY3LWyyLYgz3aFsHQk83?si=eb34e19bfdea45d5

ReferencesJournal of Clinical Lipidology 2022.Volume 16, Issue 4, July–August 472-482Guerra,DJ.2026. Unpublished Lipid LecturesBruce, J. 1965.Traintime Cream Wheels of Fire.https://music.youtube.com/watch?v=wX9muArmeFg&si=fgs8ZG-ejb8Oqrze

References J Clin Invest . 2011 Jul;121(7J Clin Med. 2023 Aug 4;12(15):5123 Guerra, DJ.2026. Unpublished LecturesBrowne, J.1972. Saturate Before Using lphttps://music.youtube.com/playlist?list=OLAK5uy_lJ1sFE8rdfS3vQyhFSQN5k0noGR_POBuo&si=kfAJaO1dc-t63DA-

ReferencesHorm Mol Biol Clin Investig.2023 Feb 17;44(3):295-303.Curr Opin Lipidol. 2017 Oct;28(5):397–402.J Atheroscler Thromb 2024 Sep 1;31(9):1263-1276.Atherosclerosis, 2005; 185, 191-200Org.Letters. 2018.Volume 20, Issue 2,Pages 333-336Guerra, DJ.2026. Unpublished LecturesMiller, S et al 1970.SMBVhttps://music.youtube.com/playlist?list=OLAK5uy_mMurbyyiMLz7bvTAJmI_j8sCs_e-NbvAM&si=KOOTFVnG4G1ZbWYm

ReferencesGuerra,DJ.2026. Unpublished LecturesSchubert. F. 1828. String Quintet in C Major D.956https://music.youtube.com/playlist?list=OLAK5uy_maiz4L5G8Q5ojuNn1qZn30aPbIRGM025Q&si=MnKSnqBqm3o9P0Ga

The FDA has approved the first mRNA flu shot: Moderna's mFlusiva – but immunologist Dr. Jessica Rose says it safety tests are flawed. “… You will find the safety data that definitively shows that more people died in the context of the mRNA-1010 injectable product than in the comparator group,” writes Dr. Rose. “You should know that the comparator group ALSO were given a flu vaccine – NOT A SALINE PLACEBO.” Reuters reports the approval covers adults 50 and older, based on a late-stage trial of more than 40,000 people that showed the shot was 26.6% more effective than a licensed standard-dose flu vaccine. But Dr. Rose says that no saline placebo was used, and the comparator group also received a flu vaccine – and that the data she's seen indicates high adverse reactions to the new shots. Dr. Kelly Victory, Chief of Emergency & Disaster Medicine at The Wellness Company, joins Wellness Company CEO Peter Gillooly to discuss RFK's push to split the childhood MMR vaccine into separate shots, new releases from Dr. Fauci's pandemic text messages, and TWC's research on Alpha-Gal. Dr. Jessica Rose is a Canadian researcher with a Bachelor's in Applied Mathematics and a Master's in Immunology from Memorial University of Newfoundland. She holds a PhD in Computational Biology from Bar Ilan University and completed postdoctoral research in Molecular Biology and Biochemistry. Follow at https://jessicasuniverse.com Dr. Kelly Victory is Chief of Emergency & Disaster Medicine at The Wellness Company and a trauma and emergency specialist with over 30 years of experience. Follow at https://x.com/DrKellyVictory Peter Gillooly is CEO of The Wellness Company. Through the organization's initiatives and products, he promotes patient-first care and individual control over health decisions. Learn more at https://drdrew.com/twc 「 SUPPORT OUR SPONSORS 」 • BIOPRO - BioPro+® is a natural formula of growth factors and peptides that support how you look, feel & perform. Learn more at ⁠https://drdrew.com/biopro⁠ • FATTY15 – The future of essential fatty acids is here! Strengthen your cells against age-related breakdown with Fatty15. Get 15% off a 90-day Starter Kit Subscription at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drdrew.com/fatty15⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ • PALEOVALLEY - "Paleovalley has a wide variety of extraordinary products that are both healthful and delicious,” says Dr. Drew. 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Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan's contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don't directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your options. 「 ABOUT THE SHOW 」 This show is for entertainment and/or informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment. 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ReferencesLipids.1982. 17, pages 551–557 Biochimica et Biophysica Acta (BBA) 1977- Lipids and Lipid Metabolism 486(3): 451-461Plant Physiol 1986 Oct;82(2):448-53Lipids 41, 739–747 (2006)Guerra, DJ.2026. Unpublished Lectures.Ungar et al. 1999. Ashokan Farewellhttps://music.youtube.com/watch?v=r9TcXmBNbtM&si=8YXv3K_RXgggy9wPTaylor, J. 1970. Sweet Baby Jameshttps://open.spotify.com/track/17PXXzOygMyXXUNLngVN5u?si=5544e583f0044dc6Hunter/Garcia.1970. Ripple. Grateful Deadhttps://open.spotify.com/track/4aQ8mFkZU6dmHaZOOKdscc?si=f0f9303fe3df49b8Tchaikovsky, PI. 1878. Violin Concerto in D Major OP. 35.https://music.youtube.com/watch?v=2CtUNOW6Xtk&si=U5dPlmzn9UNSwzrW

ReferencesBlood 2009 114:5481-5489Nature Reviews Urology2024. volume 21, 433–449 Front Biosci (Landmark Ed). 2024 Apr 11;29(4):148Guerra, DJ.2026.Unpublished Lectures.Hunter/Garcia/Lesh/Weir/Kreutzmann/Hart/Constanten/McKernan. 1969. The Eleven. Grateful Dead Live https://music.youtube.com/watch?v=c_WpX9s2_rQ&si=OhdOKy3p3iEUx-w6

Metastatic osteosarcoma remains a major clinical challenge, highlighting the need to better understand the molecular mechanisms that drive disease progression. In this talk, Moreno will present the use of an in vivo CRISPR interference (CRISPRi) screen to identify genes that promote osteosarcoma progression. She will focus on KLF5, a transcription factor that emerged as a key regulator in our studies, and discuss its potential as a therapeutic target for osteosarcoma.Marta Roman Moreno, PhD, is a postdoc fellow in the Sweet-Cordero Lab at UCSF. She has a BSc in Biochemistry from the University of Granada in Spain, and an MSc and PhD in Biomedical Research from the University of Navarra (Spain). The key focus of her work is to define key regulators of metastasis in osteosarcoma and determine the vulnerabilities that can diminish the survival of metastatic cells. Using mouse models, cell lines derived from patient samples (PDXs) and pooled in vivo CRISPR screens, she has been able to identify several potential genetic vulnerabilities in the context of metastatic osteosarcoma.

ReferencesSci. Signal. 2019;V. 12: 574 eaau2293J Periodontol. 2007. 78 (8): 1620-1626. Arch Dermatol . 2003 Dec;139(12):1577Am J Sports Med. 2014 Sep 22;42(12):2860–2868. Acta Biomed. 2019 Jan 29;90(3-S):61-65.Ageing Research Reviews 2023. Volume 86, April 10 1888Guerra, DJ.2026. Unpublished LecturesMozart, WA. 1775. Violin Concerto V. A Major. K 219. H Hahn.https://music.youtube.com/playlist?list=OLAK5uy_nbQFWxM0qMPo4MyuGxWwrP0QYDAXx7CoI&si=D6THgQwd6i6YYTZX

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Inside Dual Minds Integrative Psychiatry - Mind, Body & Biochemistry with Dr. Emily Cabrera & Phil George This week we're joined by Dr. Emily Cabrera, founder of Dual Minds Integrative Psychiatry, and Phil George, USAF (Ret.), clinical biochemist and wellness educator, for a conversation about what whole-person psychiatric care actually looks like. We dig into: Why trauma-informed, integrative care means treating mind, body, and spirit — not just symptoms How biochemistry and metabolic health connect to mental wellness Supporting veterans, first responders, and frontline healthcare workers Perinatal mental health and the realities new and expecting moms face Educational advocacy, IEPs, and navigating school systems for kids and families Busting common myths about psychiatric medication and metabolic health Whether you're a healthcare provider, a caregiver, or just curious about what integrative psychiatry really means, this episode is packed with insight from two people doing the work every day. Connecting with Emily & Phil at Dual Minds Integrative Psychology Phone: 508-233-8354 Email:  info@dualmindspsychiatry.com  Website: Home | Dual Minds Integrative Psychiatry https://dreamvisions7radio.com/paperclips-and-periods/ Connect with Kristin:  Facebook: Kristin Aurelia Instagram: kristinaurelia210   Connect with She Wise Wellness: Website: https://www.shewisewellness.com/ Website: www.shewisepublications.com Email: shewisepublications@gmail.com Instagram: https://www.instagram.com/she_wise_publications/ https://www.facebook.com/profile.php?id=100094044723450 YouTube: SHE Wise @survivingthehumanexperience https://www.youtube.com/channel/UCtYaqS-cL1WAFQKDadapxPQ

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VAERS stands for the 'Vaccine Adverse Effects Reporting System.' $ BTC 63,961 Block Height 961,091 Today's guest is Dr. Jessica Rose, PhD, MSc, BSc. Jessica is a Senior Fellow specializing in Computational Biology from Canada. She holds a Bachelor's Degree in applied mathematics and a master's degree in Immunology from Memorial University of Newfoundland, and a PhD in Computational Biology from Bar Ilan University. Dr. Rose has completed two post-doctoral degrees in Molecular Biology from the Hebrew University of Jerusalem, and in Biochemistry from the Technion Institute of Technology. She is best known for her contributions to public health and safety related to the COVID-19 injectable products, and her analyses of pharmacovigilance databases like VAERS. She joined me to discuss her analysis of the VAERS database and her critiques of the COVID-19 vaccine rollout and broader public health narratives. Key Topics: Analysis of the Vaccine Adverse Effects Reporting System (VAERS) Criticisms of COVID-19 mRNA injection data and safety Mechanisms of autoimmunity and potential side effects Data censorship and manipulation in scientific literature Historical context of vaccine liability and regulatory failures Strategies for immune optimization and health freedom Follow Jessica below. X- @JesslovesMJK https://jessicar.substack.com https://orcid.org/0000-0002-9091-4425 A huge thank you to Jessica for coming on the show! Check out my book ‘Choose Life' - https://bit.ly/4gGYqRE Pleb Service Announcements: Join 20 thousand Bitcoiners on @cluborange https://signup.cluborange.org/co/princey CONFERENCES: BTC HEL - 25th - 26th September 2026. - Helsinki https://btchel.com/ Use code BITTEN for - 10% My First Bitcoin. https://myfirstbitcoin.org/ Shills and Mench's: BITBOX - SELF CUSTODY YOUR BITCOIN - www.bitbox.swiss/bitten Use Code BITTEN THE MEETUP BREAKDWON - BITCOIN EVENTS UK - https://www.themeetupbreakdown.com/ SWAN BITCOIN - www.swan.com/bitten HODL EYEWEAR - Avoid Blue light! https://hodleyewear.com/partner/3/ PLEBEIAN MARKET - BUY AND SELL STUFF FOR SATS; https://plebeian.market/ @PlebeianMarket SATSBACK - Shop online and earn back sats! https://satsback.com/register/5AxjyPRZV8PNJGlM ALL FURTHER LINKS HERE - FOR DISCOUNTS AND OFFERS - https://vida.page/princey - https://linktr.ee/princey21m

In nature, enzymes are the catalysts that make much of biology work. They jumpstart chemical reactions that either wouldn't happen, or would happen super slowly. They break down food, build other molecules, extract energy, and more. What if we could harness evolution to engineer designer enzymes that do other specific jobs that benefit us?  Putting that idea into practice changed the game for chemistry, and earned Frances Arnold the Nobel Prize prize in 2018. She called it “directed evolution.” Today, thousands of labs use her methods to coax enzymes into doing things no one ever thought of. She joined Host Flora Lichtman in March 2026 to talk about where she sees this approach going in the future, and the personal evolution that brought her into science. Guest:  Dr. Frances Arnold is the Linus Pauling Professor of Chemical Engineering, Bioengineering and Biochemistry at the California Institute of Technology in Pasadena, California. Other episodes you may enjoy: Enzymes Are Taking On Our Plastic Problem Even Nobel Prize Winners Deal With Imposter Syndrome The transcript for this episode is available at sciencefriday.com. Subscribe to this podcast. Follow our show on Instagram, TikTok, Facebook, and Bluesky @scifri and sign up for our newsletters. Got a science question that's keeping you up at night? Call us: 877-472-4374 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Dr. Isaac Harris is an Associate Professor in the Department of Biochemistry and Biomolecular Sciences and the Center for Discovery in Cancer Research at McMaster University. Isaac's research examines the roles of antioxidants in health and disease, including how they are produced and used in cells. He is particularly interested in how cancer cells rely on antioxidant pathways to survive and grow. Isaac is working to understand why high-dose antioxidant supplements may sometimes promote cancer rather than prevent it, and whether blocking cancer cells' natural antioxidant systems could slow tumor growth. When he's not working, Isaac enjoys spending time with his wife and five-year-old daughter, doing things like coloring, playing outside, visiting the park, or eating ice cream. He also likes cooking, reading, relaxing, watching TV, and introducing his daughter to some of his favorite childhood shows like The Simpsons. He received his bachelor's of engineering degree in chemical engineering and PhD in molecular biology from the University of Toronto. Next, he conducted postdoctoral research at Harvard medical school before joining the faculty at the University of Rochester and Wilmot Cancer Institute in 2019. In 2024, he was awarded the Wilmot Community Outreach and Engagement (COE) Innovator Award. He very recently moved his lab and joined the faculty McMaster University. In this interview, Isaac shares more about his life and research.

Send us Fan MailPatrick Coles, Ph.D., is the Chief Scientist at Normal Computing, where he develops novel computing hardware for Artificial Intelligence (AI) applications. Previously, he was a Staff Scientist at Los Alamos National Lab (LANL), where he made important contributions to the theory of quantum computing.Patrick has a broad background, having done his PhD in Chemical Engineering at Berkeley and his MPhil in Biochemistry at Cambridge. Currently, Patrick is working on a new theory for cancer and chronic disease. His Toxin Sequestration Theory (TST) of cancer was featured on the cover of the Masters Of Health magazine.He regularly discusses TST in his Substack blogs and his YouTube channel. He is also passionate about the carnivore diet, which he's been doing for 19 months now.Find Patrick at-YT- @OxalateWarriorSubstack- @patrickcolesTW- @ColesThermoAIFind Boundless Body at-myboundlessbody.comBook a session with us here! 

Leyla Muedin, a registered dietitian nutritionist in New York City, discusses the growing shift from symptom-only “sick care” to a clinically grounded holistic approach to health and recovery. She argues that self-guided wellness routines can leave gaps when underlying medical issues, mental health conditions, substance use disorders, or trauma remain unaddressed, and emphasizes integrating evidence-based clinical evaluation (including labs and deficiency testing) with lifestyle practices. She explains how treating symptoms in isolation misses connections (e.g., stress, sleep, grief) and defines true holistic care as addressing physical, mental, emotional, relational, environmental, and purpose-related factors without rejecting medical treatment. Key components include consistent movement, individualized nutrition built on basics, nervous system regulation (sleep, nature, breathing, meditation/prayer), meaningful social connection, and a sense of purpose as clinically relevant to resilience.

A tiny molecule produced inside your body may play a major role in how well you circulate blood, manage inflammation, exercise, and age. In this episode of Sharkpreneur, Seth Greene interviews Nathan S. Bryan, Ph.D., Founder, Chairman, and CEO of Bryan Therapeutics, Inc., who explains nitric oxide's role in blood-vessel function, tissue oxygenation, inflammation, metabolism, and cellular energy, and shares his view on everyday habits that can affect the body's natural production. He also discusses the oral microbiome, dietary considerations, lifestyle practices, consumer education, and the research-based standards he believes people should use when evaluating nitric oxide-related products. Key Takeaways:→ Nitric oxide helps regulate blood flow, oxygen delivery, inflammation, metabolism, and cellular signaling. → Oral-care habits may affect the oral microbiome, which helps metabolize dietary nitrate.→ Green vegetables and beets may contain dietary nitrate.→ Product claims should be supported by scientific and clinical data. → Lifestyle habits influence nitric oxide production. Dr. Nathan S. Bryan earned his undergraduate Bachelor of Science degree in Biochemistry from the University of Texas at Austin and his doctoral degree from Louisiana State University School of Medicine in Shreveport, where he was the recipient of the Dean's Award for Excellence in Research. He pursued his postdoctoral training as a Kirschstein Fellow at Boston University School of Medicine's Whitaker Cardiovascular Institute. After a two-year post-doctoral fellowship, in 2006, Dr. Bryan was recruited to join the faculty at the University of Texas Health Science Center at Houston by Ferid Murad, M.D., Ph.D., 1998 Nobel Laureate in Medicine or Physiology. Dr. Bryan has been involved in nitric oxide research for the past 25 years and has made many seminal discoveries in the field, has dozens of issued patents, and has published more than 100 peer-reviewed scientific articles in some of the top science and medical journals. Dr. Bryan is a best-selling author and successful entrepreneur who has built a billion-dollar enterprise value portfolio of companies. Dr. Bryan is one of the most successful inventors and top revenue producers in the history of the University of Texas Health Sciences Center at Houston. He is currently the Founder, Chairman, and CEO of Bryan Therapeutics, Inc., a privately held, clinical-stage biotechnology company actively engaged in the discovery and development of nitric oxide-based therapies. BTI has active drug development programs in heart disease, Alzheimers' Disease, and topical drugs for diabetic ulcers and non-healing wounds. Dr. Bryan's consumer line of nitric oxide products is among the most innovative and successful on the market. Dr. Bryan is an international leader in molecular medicine and nitric oxide biochemistry. Connect With Nathan:Website: https://n1o1.com/https://bryantherapeutics.com/ Instagram: https://www.instagram.com/drnathansbryan X: https://x.com/drnitric LinkedIn: https://www.linkedin.com/in/drnathansbryan/ YouTube: https://www.youtube.com/@drnathansbryannitricoxide