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GUEST: https://leecarrollherbalist.com/ https://www.instagram.com/leecarrollherbalist/ MENTIONS: https://en.wikipedia.org/wiki/Ergothioneine https://en.wikipedia.org/wiki/Erinacine https://www.sciencedirect.com/science/article/pii/S0006295223005257 https://en.wikipedia.org/wiki/Beta-glucan MUSHROOM HOUR: https://welcometomushroomhour.com https://www.instagram.com/mushroomhourpodcast https://tiktok.com/@welcome_to_mushroom_hour Show Music courtesy of the one and only Chris Peck: https://peckthetowncrier.bandcamp.com/ TOPICS COVERED: Herbal Medicine Industry Importance of Ergothioneine Fungal Receptors in the Human Body Fungal Archaeology & EthnomycologyGourmet Ape Theory Fiber & Beta-Glucans Anti-Oxidants and Protein Turnover Fungal Lifecycle and Innovation Fungal Fermented Substrates Distinguishing Different Mycelium-Based Medicinals Assessing “Full Spectrum” Claims Nuclear Magnetic Resonance Imaging Bitter Molecule Receptors in the Heart
Send us Fan MailToday we're releasing a new episode from a brand new series called the Boundless Body Radio Heritage Series! I wanted to do something extra special to celebrate 1,000 podcast episodes recorded here at Boundless Body Radio, a milestone that we hit on June 24, 2026!These episodes are actually not new, although they might be new to you! When we first got started back in October, 2020, I was so fortunate that so many incredible people said "YES" to being hosted on the show, however, we didn't have very many listeners at the time!Today, we get thousands of downloads every single month, and are usually included in the top 150 Fitness and Nutrition Podcasts on the Apple Podcast charts!To honor our amazing guests, I will be selecting one of those original episodes and posting them here on for this special series!As I was going through these episodes again, I remembered how valuable these conversations actually were. it was really striking how much the information these experts have shared has born out to be even more accurate several years later.The audio quality of a show was not as good back then as it is now, but I still really hope you enjoy these episodes, and find them relevant and helpful to you today!Cheers, thanks as always for listening, and I really hope you enjoy this episode of the Boundless Body Radio Heritage Series!Dr. Thomas Seyfried is a returning guest on our show! Be sure to check out his first appearance on Boundless Body Radio on episode 60, which one of the most fascinating discussions we've ever had, all about cancer as a metabolic disease! He was also hosted on episode 363 of our podcast.Thomas N. Seyfried received his Ph.D. in Genetics and Biochemistry from the University of Illinois, Urbana, in 1976. He was a Postdoctoral Fellow in the Department of Neurology at the Yale University School of Medicine and then served on the faculty as an Assistant Professor in Neurology. Other awards and honors have come from such diverse organizations as the American Oil Chemists Society, the National Institutes of Health, The American Society for Neurochemistry, the Ketogenic Diet Special Interest Group of the American Epilepsy Society, the Academy of Comprehensive and Complementary Medicine, and the American College of Nutrition.Dr. Seyfried has over 150 peer-reviewed publications and is the author of the book, Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer (Wiley, 1st ed., 2012).Find Dr. Seyfried at-https://foundationformetaboliccancertherapies.com/Movie, coming soon- CANCERREVOLUTION: A Cancer Science Documentary with Dr. Seyfried and former podcast guest Travis Christofferson.Find Boundless Body at-myboundlessbody.comFind Boundless Body at-myboundlessbody.comBook a session with us here!
Quantum Scientist Patrick Coles Reveals How Tumors Protect Your Mitochondria From Toxic Overload Cancer might not be the enemy your doctor says it is. What if tumors are actually your body's emergency detox system, built on purpose to protect you from something far more dangerous? Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Patrick Coles, Ph.D., Chief Scientist at Normal Computing, where he develops novel computing hardware for AI applications. Previously a Staff Scientist at Los Alamos National Lab, Coles led their near-term quantum computing group and made significant contributions to quantum computing theory. He holds a Ph.D. in Chemical Engineering from UC Berkeley and a Master of Philosophy in Biochemistry from Cambridge, and he's currently developing a new theory for cancer and chronic disease, the subject of this conversation. His rare combination of hard physics and deep biochemistry gives him a radically different lens on one of medicine's most misunderstood diseases. Coles lays out his Toxin Sequestration Theory, a framework that reframes cancer tumors not as malignant accidents but as intentional storage vaults the body builds to sequester toxins, heavy metals, seed oils, mold, and excess glucose, away from healthy tissue and mitochondria. He and Dave connect the dots between this theory and chronic disease, biohacking fundamentals, and why chemotherapy itself behaves as a toxin that can backfire. They dig into oxalates, deuterium, linoleic acid, circadian biology, and the detox protocols that support the body's natural ability to shrink these toxic reservoirs. This conversation challenges the mainstream genetic theory of cancer, explores the metabolic theory popularized by Thomas Seyfried, and lands on a radical, functional medicine-aligned framework for anyone serious about longevity, anti-aging, and human performance. Dave and Coles also break down how sleep optimization, fasting, ketosis, and a carnivore approach to nutrition support the body's detox hierarchy, from fat tissue and the liver to moles, cysts, and eventually tumors themselves. This is essential listening for anyone serious about biohacking, functional medicine, mitochondria health, brain optimization, nootropics, and taking full control of their metabolism and longevity. You'll Learn: Why toxins may be the root cause of Alzheimer's, Parkinson's, autism, and most chronic disease How Toxin Sequestration Theory reinterprets tumors as the body's backup detox organs Why chemotherapy ranks among the most tissue-damaging toxins, and what happens when a tumor bursts The role of oxalates, deuterium, heavy metals, and seed oils in cancer cell hoarding Why moles, cysts, lipomas, and nodules may be minor versions of the same detox response How circadian rhythm, sleep, and light exposure affect the body's toxin excretion cycles What spontaneous tumor regression reveals about lowering your toxic burden Why tracking tumor progression matters no matter which treatment path you choose Thank you to our sponsors! - Download Dave's Free Peptide Guide at daveasprey.com/peptide-guide. - ZenBud | Dave's Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. - Timeline | Visit timeline.com/dave to learn more about Mitopure and get 20% off your first order for a limited time. - Just Thrive | Get a free 90-day supply of Digestive Bitters (a $90 value) when you start a 90-day Just Thrive Probiotic subscription at https://get.justthrivehealth.com/pages/asprey Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: toxin sequestration theory, cancer theory, Patrick Coles, quantum computing scientist, thermodynamic computing, Normal Computing, Los Alamos National Lab, chemotherapy toxicity, oxalates cancer, deuterium toxin, Stephanie Seneff, heavy metal detox, mycotoxins tumors, seed oils cancer, linoleic acid, oleic acid oxidation, lipid peroxidation, glucose toxicity, mitochondria downregulation, genetic theory of cancer, metabolic theory of cancer, Thomas Seyfried, spontaneous tumor regression, backup detox organ, circadian rhythm cancer, mold toxins, forever chemicals, microplastics, bile flow, activated charcoal binders, cholestyramine Resources: • Follow Patrick's Work At: https://www.instagram.com/patrickc_tst/ • Watch Gabby's Podcast At: https://www.youtube.com/@GabbyReece • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:58 – Introducing Patrick Coles 04:08 – Toxin Sequestration Theory 06:26 – Defining a Toxin 14:13 – Cancer as Backup Detox Organ 15:01 – History of the Theory 16:30 – Deuterium and Oxalates 21:31 – Cancer Theories Compared 28:06 – Chemotherapy and Toxic Overload 37:23 – Tiered Toxin Storage System 45:17 – Diet, Light, and Circadian Rhythm 50:39 – Detox Protocols and Binders See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Send us Fan MailThe biology of endogenous cannabinoids & history of cannabinoid-based therapeuticsTOPICS DISCUSSED:Anandamide vs 2-AG: The two major endocannabinoids with a shared arachidonic acid backbone but distinct head groups biological roles.On-demand production: Calcium-dependent enzymes release cannabinoids from membranes in response to neuronal activity patterns.Trafficking: Fatty acid binding proteins and extracellular microvesicles traffic endocannabinoids within and between cells.Adolescent THC: Global receptor activation during circuit wiring may contribute to cannabis use disorder and psychosis vulnerability in susceptible individuals.Enzyme inhibitors: Early FAAH clinical trial halted by off-target toxicity; MAGL inhibitors advancing in phase 2 for anxiety and addiction.Peripheral CB1: Liver receptors regulate metabolism; restricted antagonists aim to reduce weight without central psychiatric risks of the weight loss drug rimonabant.ABOUT THE GUEST: Nephi Stella, PhD is a professor at the University of Washington School of Medicine. He has studied endocannabinoid signaling for more than 25 years, focusing on therapeutic strategies that separate beneficial effects from side effects of cannabinoid-system modulation.Support the showSupport my work:Good Chemistry: Personalized, science-based health consulting. Work with Dr. Nick Jikomes directly.Affiliate Partners: Visit this link to see my affiliate partners and get discounts codes for products & services to support health.For all the ways you can support my efforts.
The FDA has approved the first mRNA flu shot: Moderna's mFlusiva – but immunologist Dr. Jessica Rose says it safety tests are flawed. “… You will find the safety data that definitively shows that more people died in the context of the mRNA-1010 injectable product than in the comparator group,” writes Dr. Rose. “You should know that the comparator group ALSO were given a flu vaccine – NOT A SALINE PLACEBO.” Reuters reports the approval covers adults 50 and older, based on a late-stage trial of more than 40,000 people that showed the shot was 26.6% more effective than a licensed standard-dose flu vaccine. But Dr. Rose says that no saline placebo was used, and the comparator group also received a flu vaccine – and that the data she's seen indicates high adverse reactions to the new shots. Dr. Kelly Victory, Chief of Emergency & Disaster Medicine at The Wellness Company, joins Wellness Company CEO Peter Gillooly to discuss RFK's push to split the childhood MMR vaccine into separate shots, new releases from Dr. Fauci's pandemic text messages, and TWC's research on Alpha-Gal. Dr. Jessica Rose is a Canadian researcher with a Bachelor's in Applied Mathematics and a Master's in Immunology from Memorial University of Newfoundland. She holds a PhD in Computational Biology from Bar Ilan University and completed postdoctoral research in Molecular Biology and Biochemistry. Follow at https://jessicasuniverse.com Dr. Kelly Victory is Chief of Emergency & Disaster Medicine at The Wellness Company and a trauma and emergency specialist with over 30 years of experience. Follow at https://x.com/DrKellyVictory Peter Gillooly is CEO of The Wellness Company. Through the organization's initiatives and products, he promotes patient-first care and individual control over health decisions. Learn more at https://drdrew.com/twc 「 SUPPORT OUR SPONSORS 」 • BIOPRO - BioPro+® is a natural formula of growth factors and peptides that support how you look, feel & perform. Learn more at https://drdrew.com/biopro • FATTY15 – The future of essential fatty acids is here! Strengthen your cells against age-related breakdown with Fatty15. Get 15% off a 90-day Starter Kit Subscription at https://drdrew.com/fatty15 • PALEOVALLEY - "Paleovalley has a wide variety of extraordinary products that are both healthful and delicious,” says Dr. Drew. "I am a huge fan of this brand and know you'll love it too!” Get 15% off your first order at https://drdrew.com/paleovalley • THE WELLNESS COMPANY - Counteract harmful spike proteins with TWC's Signature Series Spike Support Formula containing nattokinase and selenium. Learn more about TWC's supplements at https://twc.health/drew • CHAPTER - For free and unbiased Medicare help, dial (218) 521-2472 to speak with my trusted partner, Chapter, or go to https://askchapter.org/drdrew Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan's contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don't directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your options. 「 ABOUT THE SHOW 」 This show is for entertainment and/or informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment. Executive Producers • Kaleb Nation - https://kalebnation.com • Susan Pinsky - https://x.com/firstladyoflove Content Producer • Emily Barsh - https://x.com/emilytvproducer Learn more about your ad choices. Visit megaphone.fm/adchoices
Time for Pat's weekly chat with Professor Luke O'Neill, professor of biochemistry in the School of Biochemistry and Immunology at Trinity College Dublin and this week Pat and Professor O'Neil are looking at the persecution of Dr Anthony Fauci by the Trump administration.
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ReferencesFront Physiol. 2023 May 4;14:1167873.Liver Int. 2023 Nov;43(11):2351-2364.Biochem Soc Trans. 2022 Feb 28;50(1):1–11Front Biosci (Landmark Ed) 2024 Apr 11;29(4):148Guerra, DJ.2026. Unpublished LecturesMcQuin/Dylan/white/Parsons et al. 1969. Dr Byrds and Mr. Hyde lp Byrdshttps://music.youtube.com/playlist?list=OLAK5uy_mi9872sGl841pIcpxRs0c6MbrtKDqPMtM&si=5eJftnGenkOQ9SEO
ReferencesImmunity. 2019 Jan 15;50(1):37–50Sci. Signal.2019. 26 Mar : Vol. 12, Issue 574, eaau2293Biochim Biophys Acta. 2010 Oct 1;1813(4):616–622.Clin Exp Med. 2026 Jan 4;26(1):64Guerra, DJ.2026. Unpublished LecturesLennon/McCartney.1968. Dear Prudence Beatles White Albumhttps://open.spotify.com/track/5NQYyej46WQkgCbnzGD21W?si=05c7823c4eec4a7a
ReferencesBiochim Biophys Acta. 2014 Oct 29;1851(4):340–355 Phytomedicine.2025 Nov:147:157173. Clin Exp Med. 2026 Jan 4;26(1):64ABB.2025. June V768. Article# 110384Guerra, DJ.2026. Unpublished LecturesMozart, WA. 1782. Symphony 35 (Haffner) in D Major. K.385https://music.youtube.com/watch?v=AUnKeRz5n0c&si=edeBrj1Qj3v1MuaeLenon/McCartney. 1968. I Will Beatles White Albumhttps://music.youtube.com/watch?v=p-abNGP1BK4&si=amqXgN5z1ZRZD-IH
Inside Dual Minds Integrative Psychiatry - Mind, Body & Biochemistry with Dr. Emily Cabrera & Phil George This week we're joined by Dr. Emily Cabrera, founder of Dual Minds Integrative Psychiatry, and Phil George, USAF (Ret.), clinical biochemist and wellness educator, for a conversation about what whole-person psychiatric care actually looks like. We dig into: Why trauma-informed, integrative care means treating mind, body, and spirit — not just symptoms How biochemistry and metabolic health connect to mental wellness Supporting veterans, first responders, and frontline healthcare workers Perinatal mental health and the realities new and expecting moms face Educational advocacy, IEPs, and navigating school systems for kids and families Busting common myths about psychiatric medication and metabolic health Whether you're a healthcare provider, a caregiver, or just curious about what integrative psychiatry really means, this episode is packed with insight from two people doing the work every day. Connecting with Emily & Phil at Dual Minds Integrative Psychology Phone: 508-233-8354 Email: info@dualmindspsychiatry.com Website: Home | Dual Minds Integrative Psychiatry https://dreamvisions7radio.com/paperclips-and-periods/ Connect with Kristin: Facebook: Kristin Aurelia Instagram: kristinaurelia210 Connect with She Wise Wellness: Website: https://www.shewisewellness.com/ Website: www.shewisepublications.com Email: shewisepublications@gmail.com Instagram: https://www.instagram.com/she_wise_publications/ https://www.facebook.com/profile.php?id=100094044723450 YouTube: SHE Wise @survivingthehumanexperience https://www.youtube.com/channel/UCtYaqS-cL1WAFQKDadapxPQ
ReferencesInt J Clin Exp Pathol.2022 Sep 15;15(9):373–379Int Urogynecology J.2021 May;32(5):1299-1306Cureus 2020.12(8): e10047. doi:10.7759/cureus.10047UroInt 2015;95(2):227-32.Guerra, DJ. 2026. Unpublished Lectures Hunter/Garcia 1971. Goin Down the Road/Not Fade Away. Grateful Dead livehttps://open.spotify.com/track/4jQERwmCWGi44lPt8Zl2Oz?si=33cf3ed439ea417f Bruch. M. 1877. Violin Concerto 2. D Minor. Opus 44. https://music.youtube.com/watch?v=HwPD-aCqlTY&si=RtiB0NBMM3MWQMyQ
ReferencesTrends in Cell Biology, March 2016, Vol. 26, No. 3 Biochim Biophys Acta Mol Cell Res 2024 Oct;1871(7):119766. Cell Biochem Biophys 2024 Sep;82(3):2079-2094. Guerra,DJ.2026.Unpublished LecturesStills, S. 1967. Bluebird. Buffalo Springfieldhttps://open.spotify.com/track/5RXjEF5tqZFAsiPXZrcpnu?si=3bfa2380210d4248Betts, D. 1972, Blue Sky. Allman Brothershttps://open.spotify.com/track/6iX1QW1gGIVNEItnqyvFfH?si=8ba5edaaf9344a2cBerlin, I. 1926. Blue Skies Doris Dayhttps://open.spotify.com/track/6MOH6MyP3mtFIUuZrMYQNc?si=1a9c471b627a4012Miller, S.1976. Fly Like an Eaglehttps://open.spotify.com/track/3e0FzZjTXOUtiJGSClOBrI?si=eb404527fa6a49b9
VAERS stands for the 'Vaccine Adverse Effects Reporting System.' $ BTC 63,961 Block Height 961,091 Today's guest is Dr. Jessica Rose, PhD, MSc, BSc. Jessica is a Senior Fellow specializing in Computational Biology from Canada. She holds a Bachelor's Degree in applied mathematics and a master's degree in Immunology from Memorial University of Newfoundland, and a PhD in Computational Biology from Bar Ilan University. Dr. Rose has completed two post-doctoral degrees in Molecular Biology from the Hebrew University of Jerusalem, and in Biochemistry from the Technion Institute of Technology. She is best known for her contributions to public health and safety related to the COVID-19 injectable products, and her analyses of pharmacovigilance databases like VAERS. She joined me to discuss her analysis of the VAERS database and her critiques of the COVID-19 vaccine rollout and broader public health narratives. Key Topics: Analysis of the Vaccine Adverse Effects Reporting System (VAERS) Criticisms of COVID-19 mRNA injection data and safety Mechanisms of autoimmunity and potential side effects Data censorship and manipulation in scientific literature Historical context of vaccine liability and regulatory failures Strategies for immune optimization and health freedom Follow Jessica below. X- @JesslovesMJK https://jessicar.substack.com https://orcid.org/0000-0002-9091-4425 A huge thank you to Jessica for coming on the show! Check out my book ‘Choose Life' - https://bit.ly/4gGYqRE Pleb Service Announcements: Join 20 thousand Bitcoiners on @cluborange https://signup.cluborange.org/co/princey CONFERENCES: BTC HEL - 25th - 26th September 2026. - Helsinki https://btchel.com/ Use code BITTEN for - 10% My First Bitcoin. https://myfirstbitcoin.org/ Shills and Mench's: BITBOX - SELF CUSTODY YOUR BITCOIN - www.bitbox.swiss/bitten Use Code BITTEN THE MEETUP BREAKDWON - BITCOIN EVENTS UK - https://www.themeetupbreakdown.com/ SWAN BITCOIN - www.swan.com/bitten HODL EYEWEAR - Avoid Blue light! https://hodleyewear.com/partner/3/ PLEBEIAN MARKET - BUY AND SELL STUFF FOR SATS; https://plebeian.market/ @PlebeianMarket SATSBACK - Shop online and earn back sats! https://satsback.com/register/5AxjyPRZV8PNJGlM ALL FURTHER LINKS HERE - FOR DISCOUNTS AND OFFERS - https://vida.page/princey - https://linktr.ee/princey21m
ReferencesBiomedicines 2023, 11(7), 1804BMC Biology2011. 9:85The Journal of Urology2017. V. 197, Issue 1, January 159-166European Urology Focus, 2025; 10, 893-897J Biol Chem 2017 292: 20481-Guerra, DJ.2026.Unpublished LecturesLennon/McCartney/Harrison1965. Help Beatleshttps://music.youtube.com/playlist?list=OLAK5uy_lJlBwY8J0ezSODyk5eXLUlq8wCBVGybD4&si=nYgyiNCykvSnWRR3
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In nature, enzymes are the catalysts that make much of biology work. They jumpstart chemical reactions that either wouldn't happen, or would happen super slowly. They break down food, build other molecules, extract energy, and more. What if we could harness evolution to engineer designer enzymes that do other specific jobs that benefit us? Putting that idea into practice changed the game for chemistry, and earned Frances Arnold the Nobel Prize prize in 2018. She called it “directed evolution.” Today, thousands of labs use her methods to coax enzymes into doing things no one ever thought of. She joined Host Flora Lichtman in March 2026 to talk about where she sees this approach going in the future, and the personal evolution that brought her into science. Guest: Dr. Frances Arnold is the Linus Pauling Professor of Chemical Engineering, Bioengineering and Biochemistry at the California Institute of Technology in Pasadena, California. Other episodes you may enjoy: Enzymes Are Taking On Our Plastic Problem Even Nobel Prize Winners Deal With Imposter Syndrome The transcript for this episode is available at sciencefriday.com. Subscribe to this podcast. Follow our show on Instagram, TikTok, Facebook, and Bluesky @scifri and sign up for our newsletters. Got a science question that's keeping you up at night? Call us: 877-472-4374 Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Dr. Isaac Harris is an Associate Professor in the Department of Biochemistry and Biomolecular Sciences and the Center for Discovery in Cancer Research at McMaster University. Isaac's research examines the roles of antioxidants in health and disease, including how they are produced and used in cells. He is particularly interested in how cancer cells rely on antioxidant pathways to survive and grow. Isaac is working to understand why high-dose antioxidant supplements may sometimes promote cancer rather than prevent it, and whether blocking cancer cells' natural antioxidant systems could slow tumor growth. When he's not working, Isaac enjoys spending time with his wife and five-year-old daughter, doing things like coloring, playing outside, visiting the park, or eating ice cream. He also likes cooking, reading, relaxing, watching TV, and introducing his daughter to some of his favorite childhood shows like The Simpsons. He received his bachelor's of engineering degree in chemical engineering and PhD in molecular biology from the University of Toronto. Next, he conducted postdoctoral research at Harvard medical school before joining the faculty at the University of Rochester and Wilmot Cancer Institute in 2019. In 2024, he was awarded the Wilmot Community Outreach and Engagement (COE) Innovator Award. He very recently moved his lab and joined the faculty McMaster University. In this interview, Isaac shares more about his life and research.
Send us Fan MailPatrick Coles, Ph.D., is the Chief Scientist at Normal Computing, where he develops novel computing hardware for Artificial Intelligence (AI) applications. Previously, he was a Staff Scientist at Los Alamos National Lab (LANL), where he made important contributions to the theory of quantum computing.Patrick has a broad background, having done his PhD in Chemical Engineering at Berkeley and his MPhil in Biochemistry at Cambridge. Currently, Patrick is working on a new theory for cancer and chronic disease. His Toxin Sequestration Theory (TST) of cancer was featured on the cover of the Masters Of Health magazine.He regularly discusses TST in his Substack blogs and his YouTube channel. He is also passionate about the carnivore diet, which he's been doing for 19 months now.Find Patrick at-YT- @OxalateWarriorSubstack- @patrickcolesTW- @ColesThermoAIFind Boundless Body at-myboundlessbody.comBook a session with us here!
ReferencesLife Sci Alliance. 2024 Nov 22;8(2):e202402957Guerra, DJ. 2026. Unpublished Lectures.David & Linda LaFlamme 1969 Hot Summer Day. It's a Beautiful Day. https://open.spotify.com/track/2366X46R7gugVVazKbjmHf?si=aa27358472224098Bach, JS.1721. Brandenburg Concerto 3 in G Major BWV 1048.https://music.youtube.com/watch?v=Czsd13Mmcg0&si=zTrdfnW5BaniiwrhVivaldi, A. 1720. Summer G Minor RV 315https://music.youtube.com/watch?v=g65oWFMSoK0&si=TVTiExtCniDo52R3
ReferencesSensors (Basel). 2015 May 5;15(5):10481–10510.Arterioscler Thromb Vasc Biol . 2019 Feb;39(2):294-302.BMC Biochem. 2017 Sep 11;18:13.Open Biol . 2020 Oct;10(10):200128J Clin Invest. 2016 Jun 20;126(7):2419–2421Guerra, DJ. 2026. Unpublished LecturesBeethoven, LV. 1808 Symphony 6 in F Major. Op.68.https://music.youtube.com/watch?v=xWDIwsfgQnE&si=S29yakb1FSO7wnvJBerry, C. 1956. Roll Over Beethoven https://open.spotify.com/track/5ZGQVgXZiqnXNmhV0C49Tf?si=5e90e68b347d41c0
Leyla Muedin, a registered dietitian nutritionist in New York City, discusses the growing shift from symptom-only “sick care” to a clinically grounded holistic approach to health and recovery. She argues that self-guided wellness routines can leave gaps when underlying medical issues, mental health conditions, substance use disorders, or trauma remain unaddressed, and emphasizes integrating evidence-based clinical evaluation (including labs and deficiency testing) with lifestyle practices. She explains how treating symptoms in isolation misses connections (e.g., stress, sleep, grief) and defines true holistic care as addressing physical, mental, emotional, relational, environmental, and purpose-related factors without rejecting medical treatment. Key components include consistent movement, individualized nutrition built on basics, nervous system regulation (sleep, nature, breathing, meditation/prayer), meaningful social connection, and a sense of purpose as clinically relevant to resilience.
ReferencesSci Rep. 2022 May 18;12(1):8289.Mol Biol Cell. 2009 Mar 1;20(5):1454–1463. Cells. 2020 Sep; 9(9): 2125.Mol Biomed. 2025 Oct 22;6:83Guerra, DJ.2026. Unpublished LecturesSpringsteen, B. 1976. Blinded by the Light. Manfred Mannhttps://music.youtube.com/watch?v=33ptulhhQPg&si=j0k63w6aEsQ9Jg9fPage/Plant.1973. Over the Hills Led Zepplinhttps://open.spotify.com/track/2eDdFHgqNJltzlvlZFVDWd?si=3e466d97fa364802Tempchin, j. 1972 Peaceful Easy Feeling. Eagles. https://open.spotify.com/track/40h65HAR8COEoqkMwUUQHu?si=3fa71f3dee3344b9Petty, T. 1989 I Won't Back Downhttps://open.spotify.com/track/7gSQv1OHpkIoAdUiRLdmI6?si=3500edc1f25f49bb
ReferencesProc Natl Acad Sci U S A. 2004 Jul 28;101(32):11803–11808.International Urogynecology Journal (2020) 31:1495–1496Sci Rep. 2022 May 18;12(1):8289.Guerra, DJ.2026. Unpublished LecturesZappa, F. 1966. You're Probably Wondering Why I'm here. Mothers of Invention. Freak Out.lphttps://open.spotify.com/track/6K7nz8CasqgyDGnkZOZuw8?si=ce2e3d2358d041c2
A tiny molecule produced inside your body may play a major role in how well you circulate blood, manage inflammation, exercise, and age. In this episode of Sharkpreneur, Seth Greene interviews Nathan S. Bryan, Ph.D., Founder, Chairman, and CEO of Bryan Therapeutics, Inc., who explains nitric oxide's role in blood-vessel function, tissue oxygenation, inflammation, metabolism, and cellular energy, and shares his view on everyday habits that can affect the body's natural production. He also discusses the oral microbiome, dietary considerations, lifestyle practices, consumer education, and the research-based standards he believes people should use when evaluating nitric oxide-related products. Key Takeaways:→ Nitric oxide helps regulate blood flow, oxygen delivery, inflammation, metabolism, and cellular signaling. → Oral-care habits may affect the oral microbiome, which helps metabolize dietary nitrate.→ Green vegetables and beets may contain dietary nitrate.→ Product claims should be supported by scientific and clinical data. → Lifestyle habits influence nitric oxide production. Dr. Nathan S. Bryan earned his undergraduate Bachelor of Science degree in Biochemistry from the University of Texas at Austin and his doctoral degree from Louisiana State University School of Medicine in Shreveport, where he was the recipient of the Dean's Award for Excellence in Research. He pursued his postdoctoral training as a Kirschstein Fellow at Boston University School of Medicine's Whitaker Cardiovascular Institute. After a two-year post-doctoral fellowship, in 2006, Dr. Bryan was recruited to join the faculty at the University of Texas Health Science Center at Houston by Ferid Murad, M.D., Ph.D., 1998 Nobel Laureate in Medicine or Physiology. Dr. Bryan has been involved in nitric oxide research for the past 25 years and has made many seminal discoveries in the field, has dozens of issued patents, and has published more than 100 peer-reviewed scientific articles in some of the top science and medical journals. Dr. Bryan is a best-selling author and successful entrepreneur who has built a billion-dollar enterprise value portfolio of companies. Dr. Bryan is one of the most successful inventors and top revenue producers in the history of the University of Texas Health Sciences Center at Houston. He is currently the Founder, Chairman, and CEO of Bryan Therapeutics, Inc., a privately held, clinical-stage biotechnology company actively engaged in the discovery and development of nitric oxide-based therapies. BTI has active drug development programs in heart disease, Alzheimers' Disease, and topical drugs for diabetic ulcers and non-healing wounds. Dr. Bryan's consumer line of nitric oxide products is among the most innovative and successful on the market. Dr. Bryan is an international leader in molecular medicine and nitric oxide biochemistry. Connect With Nathan:Website: https://n1o1.com/https://bryantherapeutics.com/ Instagram: https://www.instagram.com/drnathansbryan X: https://x.com/drnitric LinkedIn: https://www.linkedin.com/in/drnathansbryan/ YouTube: https://www.youtube.com/@drnathansbryannitricoxide
ReferencesFree Radic Biol Med. 2021 Jul; 170: 59–69Biomolecules.2021 Feb; 11(2): 195. Immunol Res. 2020 Feb;68(1):28-38J Biol Chem. 2019 Jun 7;294(23):9213-9224Guerra, DJ. 2026. Unpublished Lectures.Hunter/Garcia.1976. Mission in the Rain. Reflections.https://music.youtube.com/watch?v=-BcsVsCEnMU&si=WdVHhRTSG5IOieW5Schubert, F. 1822. Symphony 8 in B Minor D.759.unfinished.https://music.youtube.com/watch?v=3tisvEpblig&si=vT6dC45z6oNOhk9O
Luke O'Neill, School of Biochemistry and Immunology at TCD
References J Biol Chem. 2005 Dec 2;280(48):40012-24.Current Opinion in Biotechnology 2023. V. 84, December 103011Guerra, DJ.2026. Unpublished LecturesLennon/McCartney. 1968. Rocky Racoon Beatles. White Album.https://open.spotify.com/track/1ITQbrueGLl581a25XXm9c?si=132387de1dda41b5Hunter/Garcia. 1975. Cruel White Water https://open.spotify.com/track/6IzZ1u1D2hW5cv6KPxaKcO?si=3e859cb45a884d64
ReferencesNat Metab. 2023 Aug 23;5(8):1275–1289Current Opinion in Biotechnology 2023Volume 84, December Org Lett. 2019 Dec 6;21(23):9372-9376.Dalton Trans. 2011 May 21;40(19):5228-35Guerra, DJ.2026. Unpublished LecturesHolly. B.1957. That'll Be the Dayhttps://open.spotify.com/track/4UcHTV3TjlThmMlZgOG4Kr?si=febeb64a4a0e415c
ReferencesJ Pharm Bioallied Sci. 2019 May; 11(Suppl 2):S135–S139J Oral Microbiol.2017; 9(1): 1400858.) Biomed Pharmacother 2024 Jan:170:116092.Science Advances. 2026. 19 Jun Vol 12, Issue 25. eadz3612 Guerra, DJ.2026. Unpublished Lectures.Bach, JS. 1717-1723. Violin Concertihttps://music.youtube.com/playlist?list=PLyWPWZ3LhbCUF3Bpv5XAknuLmdgCtAvZR&si=XeROf8BUuWBdS1Bx
Osteosarcoma Webinar Series: Dr. Jing Huang is a Senior Investigator and Head of the Cancer and Stem Cell Epigenetics Group in the Laboratory of Cancer Biology and Genetics at the National Cancer Institute (NCI). He received his bachelor's degree in Biochemistry from Peking University and his Ph.D. in Biochemistry and Biophysics from the University of Rochester, followed by postdoctoral training in cancer epigenetics at the Wistar Institute.Dr. Huang joined the NCI as a Principal Investigator in 2008 and earned tenure in 2016. His laboratory investigates transcriptional and epigenetic regulation in cancer and stem cells, with a major focus on the oncogenic driver RUNX2 in osteosarcoma. His ultimate goal is to develop novel therapeutic strategies and translate laboratory discoveries into clinical advances for osteosarcoma patients.
In this episode, we review the high-yield topic of Apolipoproteins from the Biochemistry section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
In this episode, we review the high-yield topic of Chromatin Structure from the Biochemistry section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
ReferencesGuerra, DJ.2026. Unpublished LecturesGut Microbes. 2022; 14(1): 2073785.Oral Microbiol Immunol. 2006 April 21(2):84-92 1647-6017J Periodontal Res. 2018 Jun; 53(3):403–413.Eur J Microbiol Immunol (Bp). 2011 Mar; 1(1): 41–58J Cell Mol Med. 2023 Apr 5;27(9):1290–1295.Whitfield and Strong; Starr, E.1970 War.https://music.youtube.com/watch?v=hZJRJpbGkG4&si=LbsesLhQxWROu7o6Vivaldi, A. 1720 Concerto for 3 violins RV 551.https://music.youtube.com/watch?v=AiK1WYzt9sY&si=TgTeBHcpo7QXzcq_Lee, A. 1971. I'd Love to Change the World. Ten Years Afterhttps://music.youtube.com/watch?v=98Q8QsEc6sI&si=fpuxrSnqrsfKChVX
Brewing beer is easy. Four simple ingredients, and a process so straightforward that the earliest beers were brewed by accident when wet grains started to germinate and ferment. But brewing consistently high-quality beer is a different challenge, and the modern brewing process extends far beyond the simple equation of beer = water + malt + hops + yeast. Differentiating your product in a competitive market is a challenge that all brewers face. Doing all of this on a tight budget is a major challenge for many brewers today. While costs can be cut to an extent by purchasing cheaper ingredients, this comes at the risk of reducing product quality, consistency, or flavor.Through careful optimization of each step of the brewing process, you can improve yields and efficiency, allowing you to continue to use the high-quality ingredients that define your brand. In this presentation, you will discover the full range of tools available in the Brewer's Toolkit. Learn how to use nutrients, enzymes, process aids, flavor additions, specific yeast strains and inactive specific yeast products to improve beer quality and brewing efficiency.Eric Abbott has a B.Sc. in Biochemistry, a M.Sc. in Botany, and 20 years of experience in the beverage industry. Since 2017, Eric has brought experience as a brewer, R&D scientist, and technical sales manager to the Lallemand Brewing technical team. As the main point of contact for brewing technical support and troubleshooting, Eric is keenly aware of the challenges that brewers face everyday. In collaboration with the Lallemand Brewing innovation team, Eric works to develop new products and resources to help brewers to improve product quality and increase brewing efficiency. Eric is a father of three daughters in the Montreal area, and he enjoys kayaking on the Rivière de Milles Iles, when it is not frozen.Join us in person for CBP Connects TampaDecember 7-9, 2026Come get inspired, leave with actionable strategies: https://cbpconnects.com/
In this episode, we review the high-yield topic of Trace Metals from the Biochemistry section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
ReferencesPNAS. 2003 Apr 29;100(10):5578–5580Discov Immunol. 2024 Nov 19;3(1):kyae016Cell Metabolism 2025. 37, 9, 2 September : 1835-1851.e10Guerra,DJ.2026. Unpublished LecturesHunter/Garcia et al. 1971. Skull and Roses Live lp. Grateful Deadhttps://music.youtube.com/playlist?list=OLAK5uy_lemewpf4G7qsRIA4YFF78p1WBGSnUCQhQ&si=OjnbWHGb99dRev-V
In this episode, we review the high-yield topic of Reverse Transcription from the Biochemistry section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
In this episode, we review the high-yield topic of Amino Acids from the Biochemistry section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
ReferencesPNAS. 2011. May 24| vol. 108 | no. 21 .E118–E127 Discov Immunol. 2024 Nov 19;3(1):kyae016Cureus. 2025 Sep26;17(9):e93294Cell Reports Medicine 2022. Volume 3, Issue 3, 15 March 100543Discov Immunol. 2024 Nov 19;3(1):kyae016.Guerra, DJ. 2026 Unpublished LecturesMcQuinn,ParsonsKelly, Hillman, Dylan, Haggard.1968.Sweetheart of the Rodeo .lp .Byrdshttps://music.youtube.com/playlist?list=OLAK5uy_kejb97oJ9VJCssjIxpz2YeHK9htTy-wz0&si=XNJafnmA_B64KHcs
ReferencesGuerra, DJ.2026. Unpublished LecturesMcClean, D. 1971 American Piehttps://open.spotify.com/track/1fDsrQ23eTAVFElUMaf38X?si=05a7bcbf872c4220
In this episode, we review the high-yield topic of Ethanol Metabolism from the Biochemistry section.Follow Medbullets on social media:Facebook: www.facebook.com/medbulletsInstagram: www.instagram.com/medbulletsofficialTwitter: www.twitter.com/medbullets
Biochemist Suzanne Pfeffer is an expert on the molecular roots of Parkinson's disease. Her work focuses on mutated proteins linked to Parkinson's risk. She's discovered, for instance, that drugs inhibiting one of the proteins can help neurons regrow primary cilia and stave off cell death, reversing disease progression. Since similar drugs are in clinical trials, her findings bring great hope for people with a subtype of Parkinson's and hopefully can be linked to earlier detection through warning signs like REM sleep disruptions and loss of smell. “This is precision medicine,” Pfeffer tells host Russ Altman of the future of Parkinson's disease on this episode of Stanford Engineering's The Future of Everything podcast. Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your question. You can send questions to thefutureofeverything@stanford.edu. Episode Reference Links: Stanford Profile: Suzanne Pfeffer Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / Facebook Chapters: (00:00:00) Introduction Russ Altman introduces guest Suzanne Pfeffer, a professor of biochemistry at Stanford University. (00:03:25) Path into Parkinson's Research How Pfeffer's protein work led to a life-changing work on Parkinson's disease. (00:05:28) Parkinson's Primer The various causes and the effects of the disease on the brain and body. (00:10:26) Lewy Bodies and Dementia How Lewy bodies, synuclein, and dementia relate to Parkinson's disease. (00:11:56) Molecular Trafficking Pfeffer breaks down the effects of LRRK2 and GBA mutations in the brain. (00:16:10) Early Disease Changes Some of the early changes in the body and how they show up as symptomatically. (00:20:04) Current Treatments The limitations of symptom-focused treatments. (00:21:46) Treating Earlier Opportunities for slowing or reversing disease progression when detected earlier. (00:22:32) Targeting LRRK2 Current research on disease treatment & trial challenges. (00:27:33) The Value of Basic Science Why curiosity-driven research can unexpectedly lead to disease breakthroughs. (00:29:33) Future In a Minute Rapid-fire Q&A: biomarkers, brain donation, and better Parkinson's treatments. (00:31:52) Conclusion Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
ReferencesDiscov Immunol. 2024 Nov 19;3(1):kyae016Cell Reports2015 Volume 13, Issue 1p132-144October 06, Guerra. DJ.2026.Unpublished Lectures.Hayward/Pinder/Thomas/Edge.1969. To Our Children's Children Moody Blueshttps://music.youtube.com/playlist?list=OLAK5uy_nUbo_GZxI3GafKmIJazCD_XP1LSA5bRX4&si=sFMKnz_osf0rlmmu
ReferencesDiscov Immunol. 2024 Nov 19;3(1):kyae016Cell Metab. 2012 Jun 6;15(6):813-26. Dev Comp Immunol . 2020 Aug:109:103694. Guerra, DJ.2026. Unpublished LecturesMozart, WA. 1791. String Quintet in E-flat major, K. 614.https://music.youtube.com/watch?v=hEFu9iV0Zxw&si=xmWnzWorPG9Xtqzy
#028 This week, Melissa and Jam travel even further down the rabbit hole of hair chemistry. How does our hair get damaged? How do we curl, straighten, and perm our hair? What's going on there at the molecular level? Let's find out! References from this episode Biochemistry, Edition 4 - Garret and Grisham Making waves: The chemistry of hair perms - Christine Herman, Chemistry & Engineering News How Did the 80s Get Hair So Big? - American Chemical Society The Chemistry of Hair - C. S. Whewell, Ph.D., F.R.I.C., F.T.I. The Science of Curls - Leidamarie Tirado-Lee Support this podcast on Patreon Buy Podcast Merch and Apparel Check out our website at chemforyourlife.com Watch our episodes on YouTube Find us on Instagram, Twitter, and Facebook @ChemForYourLife Thanks to our monthly supporters Sara Hull Dog Day Dan Bri . Summer Alden Amanda Raymond Kyle McCray Justine Ash Vince W Julie S. Heather Ragusa Autoclave Dorien VD Scott Beyer Jessie Reder J0HNTR0Y Cullyn R Erica Bee Elizabeth P Rachel Reina Letila Katrina Barnum-Huckins Suzanne Phillips Venus Rebholz Jacob Taber Brian Kimball Kristina Gotfredsen Timothy Parker Steven Boyles Chris Skupien Chelsea B Avishai Barnoy Hunter Reardon Support this podcast on Patreon Buy Podcast Merch and Apparel Check out our website at chemforyourlife.com Watch our episodes on YouTube Find us on Instagram, Twitter, and Facebook @ChemForYourLife Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Send us Fan MailSpencer Feldman is a multiple patent-holding inventor, master formulator, detoxification expert, and founder of RemedyLink. For more than 20 years, Spencer has researched and developed detoxification protocols and wellness products focused on helping people reduce toxic burden, support the body's natural detox pathways, and optimize long-term health.His work in detoxification and alternative health has helped shape an entire segment of the wellness industry — particularly in the areas of environmental medicine, heavy metals, biofilms, chronic illness support, and detox protocols.After struggling with his own health challenges, Spencer became obsessed with understanding why so many people remain chronically sick despite modern medicine.Today, Spencer is known for simplifying complex health concepts into fascinating, practical conversations that deeply resonate with podcast audiences. He combines scientific depth, unconventional thinking, personal experience, and highly actionable insights in a way that makes listeners rethink how health actually works.He is the author of the book Notes Of a Master Formulator- Principles and Protocols for Detoxification, Microbiome, and Environmental MedicineFind Spencer at-https://remedylink.com/Find Boundless Body at-myboundlessbody.comBook a session with us here!
Episode Highlights With KatieWhy the traditional biochemical model of the body is incomplete...and why the body is electric firstThe shocking amount of energy your body generates each day (about your own body weight in ATP!)Why 90–95% of chronic diseases have mitochondrial dysfunction at the rootHow your mitochondria act not just as powerhouses but as quantum batteries, antennas, and information hubsThe surprising sources of electrons that create cellular voltage...including sunlight, melanin, movement, structured water, and the earth itselfHow infrared light charges your “quantum battery,” while artificial blue light breaks it downWhy hydration with minerals is essential for building cellular charge (and why plain water can ake things worse)The nutrients mitochondria require to function: phospholipids, healthy fats, CoQ10, copper, B-vitamins, carnitine, creatine, and moreWhat redox really means and why redox balance must come before detoxHow a collapse in redox leads to the Cell Danger Response, chronic symptoms, and stalled healingThe many ways modern life drains voltage: lack of sunlight, EMFs, stress, toxins, blue light, poor sleep, dehydration, and circadian disruptionSimple daily strategies to restore voltage...starting with light, minerals, movement, grounding, and sleepHow tools like red/near-infrared light, PEMF, BioCharger, sauna, cold therapy, Juvent, and vibration plates support mitochondrial energyResources MentionedRed light therapyPEMF matBioChargerSaunasPower Plate vibration plateCold plungeJuventJustine ClassThe Body ElectricDr courtney hunt insta and websiteYour spark is light classMineral podcast seriesWater structure pitcher affiliate linkRebounder on amazon