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What if the health of your brain decades from now is being shaped by what you are doing today? We tend to think about Alzheimer's and cognitive decline as problems that show up later in life, once memory starts slipping or confusion becomes noticeable. But many of the factors associated with brain decline can begin much earlier. Blood sugar, insulin resistance, sleep, inflammation, muscle mass, exercise, social connection, oral health, and even the medications you regularly take may all influence the environment your brain is aging in. This matters because brain health gives you more areas to act on than most people realize. You can pay attention to metabolic markers before they become major problems, build and preserve muscle, protect your sleep, stay socially connected, take care of your oral microbiome, and understand which emerging therapies actually have evidence behind them. The earlier you start thinking about your brain this way, the more opportunity you have to influence how well it functions later. Dr. David Perlmutter is a board-certified neurologist, six-time New York Times bestselling author, and internationally recognized expert in brain health, nutrition, and neurodegenerative disease. His latest book, Brain Defenders, explores microglia, the brain's immune cells, and how their function may influence conditions including Alzheimer's and Parkinson's. His work focuses on giving people practical ways to protect brain health through metabolism, lifestyle, and emerging neuroscience. What's Discussed: (05:51) What research suggests about slowing or even improving cognitive decline in people already diagnosed with Alzheimer's through intensive lifestyle intervention. (10:47) Why Alzheimer's should not be viewed as purely genetic and how lifestyle and metabolic health can influence risk even when genetic predispositions are present. (12:19) How loneliness and social isolation may affect brain health through stress, cortisol, oxytocin, inflammation, and changes in the brain's immune cells. (20:50) Why the biological conditions associated with cognitive decline may begin in your 40s and 50s, decades before memory problems become obvious. (30:34) How exercise supports the brain through BDNF, irisin, and other chemicals released during muscle activity, and why both cardio and strength training matter. (38:00) Why restorative sleep is an active period for memory consolidation and brain recovery, and how fragmented sleep can undermine brain health even when you spend eight hours in bed. (1:04:34) What the science currently says about NAD, NR, NMN, and IV NAD for mitochondrial function, biological aging, and cognitive health. (1:12:04) How periodontal disease, the oral microbiome, and frequent use of certain antibacterial mouthwashes may affect nitric oxide, metabolism, and long-term brain health. (1:23:05) What emerging research says about GLP-1 drugs for Parkinson's and Alzheimer's, and why using or microdosing them specifically for brain protection is still ahead of the evidence. (1:33:25) Why homocysteine and fasting insulin are two blood markers worth paying attention to when assessing metabolic and long-term brain health. Thank You to Our Sponsors! Magic Mind: Head over to magicmind.com/jen and use code JEN at checkout. Momentous: Ready to try supplements that actually do what they claim? Head to livemomentous.com and use code JEN for 35% off your first subscription. Therasage: Visit therasage.com and use code JEN to get 15% off your order. Your skin Prolon: Prolon is offering listeners 30% off sitewide plus a $40 bonus gift when you subscribe to their 5-Day Program! Just visit prolonlife.com/JENNIFERCOHEN and use code JENNIFERCOHEN to claim your discount and your bonus gift. Tru Niagen®: For supplements that are rigorously tested, third-party verified, and actually deliver what's on the label, head to truniagen.com Find more from Jen Cohen: Website: jennifercohen.com Instagram: @therealjencohen Books: jennifercohen.com/books Speaking: jennifercohen.com/speaking-engagements Find more from Dr. David Perlmutter: Website: drperlmutter.com Instagram: @davidperlmutter Facebook: David Perlmutter M.D. YouTube: @davidperlmutterMD LinkedIn: David Perlmutte, MD Book: Brain Defenders
Dr David Sinclair is a geneticist, professor at Harvard Medical School, and author. Can human aging actually be reversed? What happens if we treat aging as a disease rather than an inevitability? And how close are scientists to turning age-reversal experiments into medicines that could radically extend our lives? Expect to learn how scientists can reset the age of cells without causing cancer, whether resveratrol and NAD supplements actually work, why three meals a day plus snacks might be marketing, the best exercise protocol for longevity, whether GLP-1s are legitimate longevity drugs, and much more... Sponsors: See discounts for all the products I use and recommend: https://chriswillx.com/deals Get a free bottle of D3K2, an AG1 Welcome Kit, and more when you first subscribe at https://ag1.info/modernwisdom Get up to 20% off Timeline's leading longevity and cellular health supplement at https://timeline.com/modernwisdom Get 160+ lab tests for just $365 and save an extra $25 at https://functionhealth.com/modernwisdom Get 35% off your first subscription on the best supplements from Momentous at https://livemomentous.com/modernwisdom Get ChatGPT to explore ideas, solve problems, and learn faster at https://chatgpt.com Extra Stuff: Get my free reading list of 100 books to read before you die: https://chriswillx.com/books Try my productivity energy drink Neutonic: https://neutonic.com/modernwisdom Episodes You Might Enjoy: #577 - David Goggins - This Is How To Master Your Life: lnkfi.re/SN-Goggins #712 - Dr Jordan Peterson - How To Destroy Your Negative Beliefs: lnkfi.re/SN-Peterson #700 - Dr Andrew Huberman - The Secret Tools To Hack Your Brain: lnkfi.re/SN-Huberman - Get In Touch: Instagram: https://www.instagram.com/chriswillx Twitter: https://www.twitter.com/chriswillx YouTube: https://www.youtube.com/modernwisdompodcast Email: https://chriswillx.com/contact - Learn more about your ad choices. Visit megaphone.fm/adchoices
Try TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/discount/davetubeTry Suppgrade Labs: https://shopsuppgradelabs.com/Try Longevity Gummies: https://www.timeline.com/partners/dave-aspreyMost people see the physical decline of aging as an inevitable process that can only be managed with medications, but this video cuts through that assumption by explaining that the smartest minds in science, including multiple Nobel Prize winners, have identified a single root cause of aging tied to a specific molecule called NAD+. You'll also learn:Why your body actively destroys NAD+ faster as you age, and why that's the real driver of fatigue and brain fogHow the gap between NAD+ production and destruction widens every year, quietly draining your cellular energyThe early signs your NAD+ levels are already too low, from slow-healing skin to workouts that take days to recover fromWhat actually flips your body's NAD+ production back on, and the exact order of diet, fasting, exercise, and supplementation that makes it workTry Danger Creatine: https://dangercoffee.com/products/danger-creatineTry TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/discount/davetubeTry Suppgrade Labs: https://shopsuppgradelabs.com/Thank you to our sponsors!ECHO Water | Go to http://echowater.com/daveand use code DAVE10 for 10% off your ECHO Flask.Viome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:00:00 – The Aging Molecule01:03 – The War Within Your Cells03:28 – Builder vs. Demolition Crew04:34 – NAD+ and Brain Function06:00 – Root Cause Over Symptoms08:31 – Fixing the Imbalance10:10 – Fasting for NAD+11:30 – The REHIT Protocol12:37 – The Supplementation StepConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Full show notes: https://bengreenfieldlife.com/504 In this solosode, you'll get the latest research on three questions I keep getting asked. First, seed oils: a brand-new randomized controlled trial put 52 adults on either a low or a typical Western intake of linoleic acid for 12 weeks, and the results are important less for what they found than for what they didn't. You'll hear why arachidonic acid didn't move, why EPA dropped instead, what that does to your inflammatory balance, which seed oils I still think are worth avoiding, and the one dietary adjustment that matters most if seed oils are part of your diet. You'll also learn the surprisingly small amount of strength training that delivers the biggest longevity payoff, according to a 30-year study of more than 147,000 people, plus why pairing it with cardio is the single best exercise combination for blood pressure. I break down concurrent training, the interference effect between AMPK and mTOR, and when combining strength and cardio in one session helps you versus when it holds you back. Finally, I answer a listener question on peptides with six practical rules for stacking them safely, including which ones should never share a syringe, which ones cancel each other out at the receptor, and an honest look at how thin the human evidence really is behind the popular Wolverine stack. Episode Sponsors: Young Goose: Cutting-edge skincare that supports your skin's cellular health. Visit younggoose.com and use code BGF10 for 10% off. ULTRA: A clean, nicotine-free, caffeine-free pouch that delivers smooth, sustained energy and focus using clinically backed nootropics and adaptogens, without the jitters or crash. Visit takeultra.com and use code BENGREENFIELD for 15% off. ButcherBox: Premium, responsibly sourced protein delivered to your door, from 100% grass-fed beef to pasture-raised chicken and wild-caught seafood. New customers get a free protein for a year, plus $20 off the first box and free shipping, at ButcherBox.com/BEN. Larine: A better-for-you chewing gum that uses nano-hydroxyapatite, the same mineral your tooth enamel is made of, to support stronger teeth and fresher breath. Visit BuyLarine.com/BEN to get up to 50% off your order. Nuchido: Nuchido TIME+ is a science-backed supplement that optimizes your body's NAD metabolism across multiple pathways to support energy, cognition, recovery, and vitality. Visit BenGreenfieldLife.com/Nuchido and use code BEN20 to save 20%.See omnystudio.com/listener for privacy information.
MAPS BOGO: https://mapsbogo.com Buy one get one free — mix and match any of the top 10 most popular programs (Anabolic, Aesthetic, Performance, 15 Minutes, Anywhere, Symmetry, Starter, Muscle Mommy, Powerlift, 40+) for $157. In this episode the guys break down why being fat and fit is objectively better than being skinny and unfit across every major health metric — longevity data, energy levels, pain and injury risk, and hormone health. They cover the research showing fit overweight individuals have similar or better mortality outcomes than normal weight but unfit people, why frailty is actually one of the highest risk categories in medicine, and why the look people chase by restricting often leads to worse health and worse aesthetics. They also get into Hadi Choopan's legendary pyramid squat session on the Smith machine working up to 500 pounds and back down, Rho Nutrition's liposomal creatine solving the digestion issue for people who can't handle regular creatine, Procter and Gamble acquiring Thorne and what it signals about where the wellness industry is heading, Philip Morris buying food companies in the 1970s and applying their addiction science to processed food, Crisp Power protein pretzels and why the combination of high protein and fiber produces unusual satiety, an Anthropic study where scientists planted a thought in Claude's neural network and it became aware something was wrong, and Myspace relaunching with a no-algorithm model led by the brothers who say they originally conceived the idea behind Facebook. Then they answer questions submitted through Instagram. SPONSORS Crisp Power (protein pretzels): https://www.crisppower.com/mindpump Code: MINDPUMP for 10% off. 28g protein per bag, high fiber, zero added sugar, vegan. Rho Nutrition (liposomal creatine, NAD+ and Glutathione): https://www.rhonutrition.com/discount/MINDPUMP Code: MINDPUMP for 20% off everything. Paleo Valley (grass-fed fermented meat sticks): https://paleovalley.com/mindpump 15% off automatically applied at checkout, no code needed. LINKS Mind Pump Store: https://mindpumpstore.com Maps Fitness Products: https://mapsfitnessproducts.com Instagram: @mindpumpmedia 0:00 - Intro 1:54 - Being fat and fit is better than being skinny and unfit — the data breakdown 5:18 - Why frailty is one of the highest risk categories in all of medicine 11:55 - Metabolic flexibility, muscle as storage and why fitness is the real multiplier 19:42 - Does looking better actually make you happier? What the data says 27:10 - Hadi Choopan's legendary pyramid squat session — 500 pounds on the Smith machine 33:18 - Greatest gym feats — the guys share their own legendary training moments 39:40 - Rho liposomal creatine — solving the digestion problem for people who can't handle regular creatine 41:32 - Procter and Gamble acquires Thorne — what it signals about the wellness industry 45:23 - Philip Morris bought food companies in the 1970s and applied their addiction science to processed food 53:34 - Crisp Power protein pretzels — why the protein and fiber combination creates unusual satiety 55:03 - Claude's neural network study — AI became aware something was planted inside it 1:01:35 - Myspace is relaunching with no algorithms — and the founders' connection to the Facebook story 1:04:36 - Q&A: What AB exercises are actually worth doing? 1:07:39 - Q&A: If muscle memory is real, why not do an aggressive cut and regain muscle after? 1:09:47 - Q&A: How to bulletproof the QL and lower back 1:11:10 - Q&A: Should you eat before a 5am workout?
This Friday, I had to play back an all-time favorite. I was honored and grateful to bring you a conversation that I recorded in person with Gurudev Sri Sri Ravi Shankar at the Art of Living Center in Los Angeles. Gurudev Sri Sri Ravi Shankar is a leader of an international movement with more than 50 million followers who do breathwork every single morning. He has worked for 40 years as a global ambassador for peace at the highest levels. I did his breathwork exercises every morning without fail for five years while fixing my mind, body and nervous system, and I have a huge amount of respect for his work in the world. It was a joy to chat with him in person and his childlike curiosity, enthusiasm for teaching, and deep understanding of the world are echoed in every word of this episode. Gurudev is a true visionary, so I am grateful that he set aside time to talk with me so I could share his wisdom with you. Thank you to our sponsors! -Qualia | If you want to take the guesswork out of maintaining high NAD+ levels as you age, go to www.qualialife.com/daveNAD to get clinically proven Qualia NAD+ backed by a 100 day money back guarantee and code DAVENAD at checkout gets you an extra 15% off.-Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade.-iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVEDave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Sri Sri Ravi Shankar, Dave Asprey, Art of Living, Sudarshan Kriya, breathwork, pranayama, meditation, non-dual consciousness, gut feeling intuition, biohacking, quantum physics consciousness, Nobel Prize physics, curiosity and childlike wonder, skepticism vs cynicism, scientific temper, dogmatism, veterans PTSD breathwork, SKY campus happiness program, violence prevention, community building, dating apps romance, Elon Musk Mars, computer chip brain implant, duality and consciousness, equanimity, ego and inner voice, spirituality and science, yoga philosophy, guru interview, positive energy radiation, transcending fear Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 - Trailer01:11 - Curiosity & Skepticism03:42 - Reality, Physics & Illusion06:34 - Non-Dual Consciousness08:37 - Origins of Breathwork13:36 - Trusting Your Gut Feeling14:28 - Violence, Peace & Veterans19:54 - Romance & Dating Apps23:44 - Science Behind Meditation27:27 - Fear of the UnknownSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
To Support the work of Apologia -Our newest sponsor is Dominion Wealth Strategists! -Get the NAD treatment Jeff is on, go to Ion Layer and put “IONAPOLOGIA” into the coupon code and get $100 off your first three months! -Check out Amtac Blades and use code APOLOGIA in the check out for 5% off! -You can get in touch with Heritage Defense and use coupon code “APOLOGIA” to get your first month free! -For some Presip Blend Coffee Check out our Store. -Check out the Ezra Institute
For several years, Kim Constable woke at approximately 3:45 or 4 a.m. almost every morning. Because she was running a rapidly growing company, managing a worldwide team, raising four children and constantly thinking about the next idea, she did not initially see it as a problem. She assumed her brain was simply ready to work. The early mornings were productive—but behind that productivity, Kim was exhausted. As she moved further into perimenopause, the disrupted sleep became increasingly difficult to ignore. She began experiencing night sweats, headaches, racing thoughts, frequent nighttime bathroom trips and the deeply frustrating feeling of being exhausted while still unable to fall or remain asleep. In this candid episode, Kim shares the personal story of how menopause changed her sleep and the research journey she began in an attempt to understand it. She discusses her experience with HRT, the roles she believes estrogen and progesterone played in her symptoms and what happened after she had a Mirena coil fitted and was no longer taking oral progesterone. Kim also explains why she returned to her menopause doctor to discuss her sleep and anxiety. The episode then moves into Kim's exploration of GLP-1s and emerging peptide research. She shares the changes she personally noticed in her sleep after beginning a GLP-1 and describes what she observed while investigating DSIP and ipamorelin. Inside this episode: • Why Kim treated years of 4 a.m. waking as productivity rather than a symptom • How perimenopause disrupted her sleep over time • Night sweats, headaches, racing thoughts and repeated bathroom trips • The impact of living and working under sustained pressure • Kim's personal experience with HRT, estrogen and progesterone • What changed after having a Mirena coil fitted • Why low blood sugar and going to bed hungry sometimes affected her sleep • The mistake Kim and Ryan made by taking NAD+ at night • How Kim discovered delta sleep-inducing peptide, or DSIP • What she personally observed through her Oura Ring • Why DSIP did not feel like a conventional sleeping tablet • Kim's exploration of ipamorelin and the changes she noticed in her night sweats • Why personal experience should never be mistaken for medical evidence or a protocol This is an honest, unscripted conversation about one of the most disruptive—and often misunderstood—parts of perimenopause and menopause. Kim's experience is individual. Nothing in this episode should be interpreted as medical advice, a treatment recommendation or evidence that another person will experience the same results. This podcast is for educational and informational purposes only. Kim is not a doctor or licensed medical practitioner. Nothing discussed is a recommendation to purchase, reconstitute, dose, administer or use any research product. Research products supplied by Verified Vials are intended strictly for laboratory research and are not for human consumption or medical use. Always speak with an appropriately qualified healthcare professional about persistent sleep disruption, menopause symptoms, HRT or any health-related decision. ✨ Follow Kim Constable online for more real talk and daily motivation:
Accredited investors wanting to participate in our Catalina Island + Bodega Bay opportunities visit somerscapital.com/investIn this episode, Rich Somers sits down with Dr. Nathan Bryan, a nitric oxide scientist, to break down why this molecule plays such an important role in blood flow, energy, brain function, and longevity. Dr. Bryan explains his perspective on how declining nitric oxide production may contribute to brain fog, high blood pressure, erectile dysfunction, and other age-related health problems, while sharing ways people can support healthy nitric oxide production.They also dive into sleep, mouth breathing, nasal breathing, exercise, fasting, diet, NAD+, NMN, and the everyday habits that may be affecting your energy and performance. Dr. Bryan shares the routines he personally uses, why he believes blood flow is foundational to feeling and performing your best, and what people should understand about optimizing their health as they get older.Use code RICH at www.n1o1.com for 10% off our nitric oxide products. Connect with Rich on Instagram: @rich_somers
NAD supplements, IVs, and patches are everywhere — and for a lot of women they do nothing or make things worse. Liz Roman and Becca Chilczenkowski explain why: an enzyme called CD38 consumes NAD and gets more active the more inflamed you are, so a big IV dose in an inflamed body can drive inflammation, anxiety, and autoimmune flares instead of energy. Inside: what NAD actually does, the three mitochondrial genes that decide if it works, NR vs NMN, and the 663-Dalton reason patches don't absorb. *** CONNECT:
It's official: AHSOKA Season 2 releases on January 20, 2026! The reveal was made at D23 (i.e. the Disney convention), and along with the release date, they also blessed us with the first trailer for the show!This was a jampacked trailer featuring, Force Ghost Anakin Skywalker, flashbacks of Anakin and Ahsoka during the Clone Wars (who is that guy wielding the teal lightsaber?!), Ezra and Zeb reunion, B-WINGS!, space battles, NIGHTSISTERS, and the bluest daddy of them all: THRAWN.It' a lot more than we were expecting and changed our plans from discussing THE NINTH JEDI. Today we return after a small vacation to discuss all the vibes from this trailer, what we liked, what we're dubious about, and most important of all: is Thrawn's wig better this time around?• • •TRIAD Of The FORCE is a STAR WARS+ podcast hosted by Gus, Nani, Nad, & Chase—Puerto Rican and queer creators sharing deep dives, and heartfelt conversations from a galaxy far, far away. Featured on the STAR WARS CELEBRATION Podcast Stage (2022 & 2023), we explore STAR WARS, fantasy, comic books, and other POP-culture media honestly. We engage in inclusive commentary across film, TV, books, comics, and beyond with humor, critical analysis, and cultural perspective (without the toxicity).Follow TRIAD Of The FORCE at:BlueSky: https://bsky.app/profile/triadoftheforce.bsky.socialInstagram: https://www.instagram.com/triadoftheforce/YouTube: https://www.youtube.com/c/TriadoftheForce/If you like us, get some merch and help the channel:TeePublic: https://www.teepublic.com/user/triad-of-the-force• • •Acknowledgement: The Intro and Outro music is the Triad of the Force Theme, composed and performed by Grushkov with full permission for use by Grushkov (https://linktr.ee/Grushkov).• • •This channel is not affiliated in any way with Lucasfilm Ltd. LLC, The Walt Disney Company, or any of their affiliates or subsidiaries.
Save Up To $600: SUNLIGHTEN.COM/DAVETry TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/discount/davetubeTry Suppgrade Labs: https://shopsuppgradelabs.com/Most people see chronic fatigue and brain fog as permanent conditions caused by getting older, but this video cuts through that misconception by explaining that these symptoms are actually the direct result of damaged mitochondria piling up inside your cells because a specific longevity switch called mitophagy has been turned off. You'll also learn:Why mitophagy, not aging, controls fatigue and brain fogHow damaged mitochondria pile up when this switch turns offThe early signs your mitophagy switch is underperformingWhat actually flips mitophagy back onTry Danger Creatine: https://dangercoffee.com/products/danger-creatineTry TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/discount/davetubeTry Suppgrade Labs: https://shopsuppgradelabs.com/Thank you to our sponsors!PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off.Viome | Check it out at viome.com and use code 16DAVE for 16% off. It's time to stop guessing and start knowing your body.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:00:00 – The Longevity Switch00:59 – Mitochondria: Power Plants02:14 – What Is Mitophagy04:05 – How Stress Blocks It05:36 – Exercise Extremes07:29 – NAD+ and Silent Damage08:59 – Reversing It: Fasting10:27 – REHIT and Cold Exposure12:02 – The Supplement StackConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
To Support the work of Apologia -Our newest sponsor is Dominion Wealth Strategists! -Get the NAD treatment Jeff is on, go to Ion Layer and put “IONAPOLOGIA” into the coupon code and get $100 off your first three months! -Check out Amtac Blades and use code APOLOGIA in the check out for 5% off! -You can get in touch with Heritage Defense and use coupon code “APOLOGIA” to get your first month free! -For some Presip Blend Coffee Check out our Store. -Check out the Ezra Institute
Full show notes: https://bengreenfieldlife.com/blackseedoil In this episode with Dr. Michael Murray, one of the most respected figures in natural medicine and the formulator of ThymoQuin®, you'll discover the science behind black seed oil: what thymoquinone actually is, why the full spectrum of the seed's compounds matters more than chasing a single active ingredient, and why it may be the most powerful adaptogen yet measured for lowering cortisol, dropping the stress hormone 22 to 44% in stressed people. You'll hear how it supports your gut by calming harmful bacteria without wiping out the good ones, the surprising dose range where it helps rather than harms your microbiome, and its effects on inflammation, metabolic health, blood pressure, blood sugar, sleep, and candida. Dr. Murray also explains what makes his USP-monographed ThymoQuin different from ordinary black seed oil, why keeping free fatty acids low keeps it active, how to spot adulterated products, and the simple daily protocol he follows himself at 68. It's a grounded, myth-busting look at one of the oldest plant medicines on earth. Episode Sponsors: Just Thrive: The Gut Essentials Bundle pairs a probiotic clinically proven to arrive 100% alive in your gut with Digestive Bitters, 12 science-backed herbs that support digestion and GLP-1 production. Visit justthrivehealth.com/BEN and save 20% with code BEN, or get a full refund if you don't notice a difference. Tecton Ketones: Bioidentical D-beta-hydroxybutyrate (BHB), the same ketone your body makes in ketosis, for clean cognitive support and stable energy with no conversion step. Visit tectonketones.com/ben and use code BEN for 16% off your first order. Young Goose: Cutting-edge skincare that supports your skin's cellular health. Visit younggoose.com and use code BGF10 for 10% off. Sunlighten: Patented infrared sauna technology delivering near-, mid-, and far-infrared wavelengths to reduce inflammation, boost mitochondrial function, and enhance detox and recovery. Save up to $1,600 at get.sunlighten.com/ben with code BEN. Nuchido: Nuchido TIME+ is a science-backed supplement that optimizes your body's NAD metabolism across multiple pathways to support energy, cognition, recovery, and vitality. Visit BenGreenfieldLife.com/Nuchido and use code BEN20 to save 20%. BON CHARGE: A holistic wellness brand whose products help you sleep better, recover faster, balance hormones, and reduce inflammation. Go to boncharge.com/GREENFIELD and use code GREENFIELD to save 15%.See omnystudio.com/listener for privacy information.
Charles Brenner breaks down what the science actually says about NAD+, separating established findings from the claims commonly made in the longevity space. He explains why NAD levels in tissues may matter more than blood measurements, how metabolic stress, alcohol, inflammation, and other conditions can disrupt the NAD system, and how nicotinamide riboside (NR) compares with niacin, nicotinamide, and NMN. The conversation also covers research on exercise recovery, peripheral artery disease, skin health, infection, and wound healing, along with the limitations of current human evidence. Brenner explains why he advises against IV and subcutaneous NAD+, discusses concerns around NMN quality, and challenges popular sirtuin-centered theories of anti-aging while emphasizing the importance of reproducible human research. Charles Brenner is an NAD metabolism researcher whose work focuses on cellular bioenergetics, vitamin B3 biology, metabolic stress, and the pathways that regulate NAD production and utilization throughout the body. Now based at the University of Helsinki, his research has examined how the NAD system responds to conditions ranging from metabolic and liver disease to mitochondrial dysfunction, inflammation, and neurological stress. His work has also helped advance research into nicotinamide riboside as an NAD precursor and its potential applications in human health. Brenner takes an evidence-first approach to longevity science, distinguishing findings supported by controlled human studies from promising but still unproven mechanisms, animal research, and anecdotal claims. Brenner Lab — Charles Brenner, PhD https://www.brennerlab.net/ Niagen NR Clinical Studies — Niagen Bioscience https://www.niagenbioscience.com/pages/clinical-studies Nicotinamide Riboside for Peripheral Artery Disease — Mary M. McDermott et al. https://pubmed.ncbi.nlm.nih.gov/38871717/ This is the PAD study discussed in the episode where NR improved six-minute walking performance. NOPARK: Nicotinamide Riboside in Early Parkinson's Disease — Haukeland University Hospital / Norwegian Research Team https://clinicaltrials.gov/study/NCT03568968 This is the 400-participant, 52-week Parkinson's trial discussed in the transcript. Effects of Nicotinamide Riboside in Long COVID — Chao-Yi Wu, Edmarie Guzmán-Vélez, Charles Brenner et al. https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370%2825%2900567-X/fulltext This is the Long COVID study Brenner references when discussing cognition, fatigue, sleep, and symptom recovery. NAD+ Metabolome in Alcohol-Related Liver Disease — Richard Parker, Charles Brenner et al. https://pubmed.ncbi.nlm.nih.gov/32766477/ This is the human alcohol-related liver disease research Brenner discusses when explaining disturbed liver NAD metabolism. Nicotinamide for Skin-Cancer Chemoprevention — Andrew C. Chen et al. https://pubmed.ncbi.nlm.nih.gov/26488693/ This is the major Australian study relevant to Brenner's discussion of oral nicotinamide and skin cancer protection. Charles Brenner on NAD+, NR vs. NMN & NAD IVs — Dr. Rhonda Patrick / FoundMyFitness https://www.foundmyfitness.com/episodes/charles-brenner Dr. Mike specifically references Brenner's appearance with Rhonda Patrick during the episode. Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:58 NAD Basics Explained 02:22 Cellular Role of NAD 03:21 Proven Benefits and Trials 05:24 Inflammation Markers Deep Dive 09:19 Athletes Recovery and VO2 Max 13:52 Does NAD Decline With Age 20:10 Skin NAD and UV Damage 23:40 Who Should Take NR 27:56 Niacin vs NR vs NMN 32:28 NMN Conversion and Quality 35:37 IV and Injection Warnings 42:18 Dosing Timing and Alcohol 46:50 Addiction Claims and Dream Trials 51:39 Parkinsons and Long COVID Data 55:03 Sinclair Critique Revisited 57:05 Stacking Supplements and Metformin 59:58 Wrap Up and Where to Follow The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
Charles Brenner breaks down what the science actually says about NAD+, separating established findings from the claims commonly made in the longevity space. He explains why NAD levels in tissues may matter more than blood measurements, how metabolic stress, alcohol, inflammation, and other conditions can disrupt the NAD system, and how nicotinamide riboside (NR) compares with niacin, nicotinamide, and NMN. The conversation also covers research on exercise recovery, peripheral artery disease, skin health, infection, and wound healing, along with the limitations of current human evidence. Brenner explains why he advises against IV and subcutaneous NAD+, discusses concerns around NMN quality, and challenges popular sirtuin-centered theories of anti-aging while emphasizing the importance of reproducible human research. Charles Brenner is an NAD metabolism researcher whose work focuses on cellular bioenergetics, vitamin B3 biology, metabolic stress, and the pathways that regulate NAD production and utilization throughout the body. Now based at the University of Helsinki, his research has examined how the NAD system responds to conditions ranging from metabolic and liver disease to mitochondrial dysfunction, inflammation, and neurological stress. His work has also helped advance research into nicotinamide riboside as an NAD precursor and its potential applications in human health. Brenner takes an evidence-first approach to longevity science, distinguishing findings supported by controlled human studies from promising but still unproven mechanisms, animal research, and anecdotal claims. Brenner Lab — Charles Brenner, PhD https://www.brennerlab.net/ Niagen NR Clinical Studies — Niagen Bioscience https://www.niagenbioscience.com/pages/clinical-studies Nicotinamide Riboside for Peripheral Artery Disease — Mary M. McDermott et al. https://pubmed.ncbi.nlm.nih.gov/38871717/ This is the PAD study discussed in the episode where NR improved six-minute walking performance. NOPARK: Nicotinamide Riboside in Early Parkinson's Disease — Haukeland University Hospital / Norwegian Research Team https://clinicaltrials.gov/study/NCT03568968 This is the 400-participant, 52-week Parkinson's trial discussed in the transcript. Effects of Nicotinamide Riboside in Long COVID — Chao-Yi Wu, Edmarie Guzmán-Vélez, Charles Brenner et al. https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370%2825%2900567-X/fulltext This is the Long COVID study Brenner references when discussing cognition, fatigue, sleep, and symptom recovery. NAD+ Metabolome in Alcohol-Related Liver Disease — Richard Parker, Charles Brenner et al. https://pubmed.ncbi.nlm.nih.gov/32766477/ This is the human alcohol-related liver disease research Brenner discusses when explaining disturbed liver NAD metabolism. Nicotinamide for Skin-Cancer Chemoprevention — Andrew C. Chen et al. https://pubmed.ncbi.nlm.nih.gov/26488693/ This is the major Australian study relevant to Brenner's discussion of oral nicotinamide and skin cancer protection. Charles Brenner on NAD+, NR vs. NMN & NAD IVs — Dr. Rhonda Patrick / FoundMyFitness https://www.foundmyfitness.com/episodes/charles-brenner Dr. Mike specifically references Brenner's appearance with Rhonda Patrick during the episode. Show Notes 00:00 Welcome to the Hart2Heart Podcast 00:58 NAD Basics Explained 02:22 Cellular Role of NAD 03:21 Proven Benefits and Trials 05:24 Inflammation Markers Deep Dive 09:19 Athletes Recovery and VO2 Max 13:52 Does NAD Decline With Age 20:10 Skin NAD and UV Damage 23:40 Who Should Take NR 27:56 Niacin vs NR vs NMN 32:28 NMN Conversion and Quality 35:37 IV and Injection Warnings 42:18 Dosing Timing and Alcohol 46:50 Addiction Claims and Dream Trials 51:39 Parkinsons and Long COVID Data 55:03 Sinclair Critique Revisited 57:05 Stacking Supplements and Metformin 59:58 Wrap Up and Where to Follow The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being. Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart
Let's kick things off by answering the big question: What exactly is KPV? KPV is a small peptide consisting of just three amino acids, lysine-proline-valine. It's a fragment of the larger peptide alpha-melanocyte-stimulating hormone (α-MSH), which is involved in skin pigmentation and immune function. KPV is naturally found in the body and is known for its anti-inflammatory properties, but it has a more specific action on inflammation-related pathways that contribute to various health conditions. This peptide has been gaining popularity due to its potential in reducing inflammation, improving skin health, and supporting overall wellness, particularly in individuals with chronic conditions. Read the Full Episode Transcript: https://pepties.com/kpv-benefits/ Related Links/Products Mentioned: Peptide Podcast Partners Page https://pepties.com/partners/ Buy Peptides online at BioLongevity Labs: Use our link and enter COUPON CODE: PEPTIDEPODCAST at checkout to receive 15% off your total order: https://go.biolongevitylabs.com/SH5C Momentous Supplements (we use Creatine, Vital Aminos, Whey Protein) https://crrnt.app/MOME/OqGQOxGA LMNT – More Salt, Not Less. https://elementallabs.refr.cc/default/u/johnjavit Thorne Supplements (we use Omega-3 with CoQ10, Red Yeast Rice, Zinc) https://get.aspr.app/SH1KvW Organifi Creatine and Shilajit Gummies http://rwrd.io/rlbkajm?c MitoZen (methylene blue for Cognitive Function, Anti-Aging, Mental Clarity) https://www.mitozen.com/ref/cnlwiztypt/ For skin and hair health (Copper Tripeptide-1) Visit Luminose by Entera for an exclusive offer for Peptide Podcast listeners! ** Promo code PEPTIDEPODCAST at checkout for 10% off an order or 10% off the first month of a subscribe-and-save. ** https://www.enteraskincare.com/?rfsn=8906839.f93c72 NAD+ Push Patch: https://www.pushpatch.com/
My síce bežíme za Nadáciu Dobrý skutok, ale čerpať z toho budú aj naše dievčatá. Pre mňa je to totiž čas oddychu, po ktorom sa vraciam do rodiny oddýchnutá. Janko teraz oddych nepotrebuje. Ako som sa dozvedela, má obdobie, keď je s nimi rád.
Kiedyś Tatry tętniły… przemysłem. Jak to możliwe? „Kompletnie nie kojarzymy dziś Tatr z tym, że tu był przemysł”. A był! Bo skąd wzięła się choćby nazwa Kuźnice? Od kuźni „Młot Anny”. Nad doliną szła łuna z płonącego pieca. Na górskich szlakach pod cienką warstwą ziemi do dziś kryje się niesamowita historia. Warstwa czasu. Dziś znów przyglądamy się śmieciom, ale nie tym współczesnym, lecz historycznym. Czy powinny podlegać ochronie? Zastanawiamy się nad tym razem z Pawłem Skawińskim, dawnym dyrektorem TPN oraz leśnikami z Obwodu Kuźnice. Szukamy pod nogami zielonej szlaki i śladów po dawnej drodze górniczej. Posłuchaj kolejnego odcinka podcastu „Z miłości do gór” w ramach nowej serii „Świadomi Tatr”. W jej ramach powstaną aż 42 odcinki. Scenariusz, nagrania, montaż: Bartek Solik ___ Projekt realizowany jest w ramach Funduszy Europejskich na Infrastrukturę, Klimat i Środowisko FENX.01.05 Ochrona przyrody i rozwój zielonej infrastruktury, Typ FENX.01.05.4 Rozwój zdolności i usprawnianie zarządzania obszarami chronionymi Bazy edukacyjnej w parkach narodowych, Priorytet FENX.01 Wsparcie sektorów energetyka i środowisko.
What is the Glow Stack, and why are BPC-157, TB-500, GHK-Cu and NAD+ attracting so much attention in recovery, menopause and longevity research? In this episode, Kim Constable shares the personal story behind her introduction to peptides and the four-compound combination she refers to as the Glow Stack. As Kim moved further into menopause, she noticed that her body was no longer recovering as it once had. Her joints hurt, her gluteal tendinopathy became increasingly painful, training felt harder and she frequently woke feeling tired, stiff and inflamed. After discovering GLP-1s and experiencing changes in her own joint pain, digestion and brain fog, Kim began researching the wider world of peptides. Her early research led her to BPC-157 and TB-500, followed later by GHK-Cu and NAD+. Kim shares the changes she personally noticed after combining these compounds, including changes in recovery, strength, sleep, energy, skin, nail growth and hair growth. She then moves beyond her own experience to explain what each compound is being investigated for. Inside this episode: • How menopause affected Kim's recovery, joints and energy • Why she first began researching BPC-157 and TB-500 • What BPC-157 is being studied for in relation to tissue repair and blood-vessel formation • How TB-500 may support the migration of repair cells through damaged tissue • Why GHK-Cu is being investigated for collagen, inflammation and skin structure • The role NAD+ plays in cellular energy and ATP production • How the four compounds may work together rather than performing the same job • The changes Kim personally noticed in her skin, hair, nails, recovery and strength • Why personal experience is not the same as clinical evidence • The limitations of the existing research, particularly where human trials are limited • Potential risks, individual reactions and the importance of regular blood testing • Why hormone health and HRT may still form the foundation of menopause support • Why a compound that appears helpful for one woman may not suit another Kim explains the science using a construction-site analogy: BPC-157 may help create the pathways, TB-500 may support the cellular vehicles travelling through them, GHK-Cu may provide the rebuilding instructions and NAD+ supplies the energy needed to power the work. This episode is an accessible introduction for women who are curious about peptide research but want the mechanisms, limitations and personal experiences explained in straightforward language. This podcast is for educational and informational purposes only. Kim is not a doctor or licensed medical practitioner, and nothing discussed should be interpreted as medical advice, a treatment recommendation or a personal protocol. Nothing in this episode is a recommendation to purchase, reconstitute, dose, administer or use any research product. Research products supplied by Verified Vials are intended strictly for laboratory research and are not for human consumption or medical use. Always consult an appropriately qualified healthcare professional about your individual health. ✨ Follow Kim Constable online for more real talk and daily motivation:
In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Allen Bookatz, and Jodi Duval explore one of the most overlooked causes of declining cellular energy: the structural breakdown of the mitochondrial membrane. While many people invest in premium longevity supplements like NAD+, NMN, and CoQ10 to improve energy production, emerging research suggests these compounds cannot overcome a damaged mitochondrial membrane. The team explains how age-related phosphatidylcholine depletion weakens the mitochondrial lipid bilayer, causing proton leakage, oxidative stress, and reduced ATP production, even when the biochemical machinery appears intact. From membrane lipidomics and clinical metabolomics to phosphatidylcholine replacement and methylation support, this discussion reframes mitochondrial health through the lens of structural integrity rather than simply adding more fuel. Join us as we delve into: The Leaky Mitochondria Problem: Why declining phosphatidylcholine causes proton leaks that reduce ATP production and accelerate mitochondrial aging. Why NAD+, NMN & CoQ10 Sometimes Fail: How expensive mitochondrial supplements cannot restore energy when the mitochondrial membrane itself has become structurally compromised. Pathogenesis vs. Salutogenesis: Why Health Optimization Medicine focuses on building the biology of health instead of simply preventing disease. Clinical Metabolomics & Membrane Lipidomics: How measuring functional biomarkers provides deeper insight into cellular health than conventional blood tests alone. Phosphatidylcholine Replacement Therapy: Why rebuilding mitochondrial membranes with pharmaceutical-grade phosphatidylcholine, methyl donors, and chronobiology may improve bioenergetics. The Prevention Paradigm Shift: Why optimizing membrane integrity may become a foundational strategy for supporting healthy aging and cellular resilience. This episode is for you if: You are taking NAD+, NMN, CoQ10, or other mitochondrial supplements but still struggle with fatigue or poor recovery. You want to understand why mitochondrial membrane health may be more important than simply increasing energy substrates. You are interested in clinical metabolomics, membrane lipidomics, and the future of precision lifestyle medicine. You want to learn how phosphatidylcholine and methylation support contribute to healthy mitochondrial function. You can also find this episode on… YouTube: Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products
What does the science actually say about living longer, aging better, and maintaining peak performance? In this episode, Michael Linares, CEO of Longevity Farms, explores the emerging research behind cellular health, mitochondrial function, NAD+, and evidence-based approaches to optimizing longevity. With over 15 years of experience as a personal trainer and nurse educator, Michael has dedicated his career to understanding human physiology, recovery, and the biological mechanisms that influence aging. Through Longevity Farms, he combines education and targeted supplementation to help individuals support energy, resilience, and long-term wellness. In this conversation, we explore: · The key factors that influence healthy aging and longevity. · Why mitochondrial health is essential for energy, recovery, and cellular function. · The role of NAD+ in supporting the body's aging process. · How emerging longevity science is changing the way we approach wellness and performance. · Practical strategies for improving healthspan and maintaining vitality over time. Whether you're interested in biohacking, cellular optimization, or simply aging with more energy and resilience, this episode offers a closer look at the science shaping the future of longevity. Connect with Michael Linares through Instagram and Longevity Farms. Episode also available on Apple Podcasts: https://apple.co/38oMlMr
LeeAnne went to Nashville questioning whether she still had it in her to build again. She came home with something she did not expect: certainty.This episode is the honest version of what happened inNashville - not a highlight reel. Before the conference even started, there was a 4am blowout in the hotel room that could have derailed the whole trip. It did not. Because ten years out from her ostomy, LeeAnne has learned that these moments are not the story. They are just part of living a full life.At the conference, something shifted. She sat in roomswhere scientists talked about longevity in a way that finally connected all the dots - why aging starts inside your cells before it shows up in the mirror, why small daily habits matter more than any single intervention, and why communityis not a nice extra but an actual driver of health outcomes. She watched John - 67 years old, recently retired - decide he wants to take better care of himself and be part of what she is building. And she left knowing her direction.Longevity is not just your health. It is your financial future. It is your marriage. It is how you function every single day. That iswhat this episode is really about.In this episode:- The honest reason she and John went to Nashville - and thequestion she was carrying going in- The 4am ostomy blowout in the hotel room that could havederailed everything - and did not- What she heard from scientists about longevity, NAD+, and why aging starts in your cells- The data point about community that deserves more attention than it gets- Watching John at 67 decide he wants to get healthier and build alongside her- Why longevity is not just a health conversation - it isfinancial, relational, and daily- The BioAge longevity event - what it is and how to register- What she came home certain about after five days of questioningI went in questioning. I came out answered. I know my direction. I know where I am going.Connect with LeeAnne:- Instagram: @leeannehayden- Website: leeannehayden.com- BioAge Longevity Event: Register here - Tuesday August 18,approximately 30 minutes, free:https://us06web.zoom.us/meeting/register/uKtldVrNTvKnrBGSOVKCtg
Exosomes have become one of the most talked-about ingredients in advanced skincare, but the conversation around them can get confusing fast. Some people hear “cellular messaging” and worry about DNA. Others see plant exosomes, stem cell claims, growth factors, or vampire facial comparisons and assume all exosome products are working the same way.The problem is that the word “exosome” does not tell you enough. Exosomes are messengers, and the message depends on the source. A plant-derived exosome, a mesenchymal-derived exosome, and a platelet-derived exosome are not carrying the same type of signal for the skin. So before you trust the trend, it helps to understand what kind of message your skin is actually receiving.In this Biohacking Beauty Q&A, we break down the biggest questions listeners have been asking about exosomes. We get into why exosomes do not change your DNA, what microRNA messaging means, why consistency matters, how plant exosomes compare to human-derived options, why platelet-derived exosomes may be especially relevant for skin repair, and what makes Vampire Exosomes® different from other exosome serums.What's Discussed:03:05 Whether exosomes can change your DNA or transfer genetic material.07:08 How exosomes work through microRNA messaging instead of changing your genome.09:21 Why exosome messages do not stick around forever and need consistency.11:02 Where exosomes come from and why the source of the message matters.13:45 Why plant exosomes may offer some benefits, but may not be the strongest fit for skin repair.21:34 How mesenchymal-derived and platelet-derived exosomes differ in their relationship to skin repair.27:29 What makes Vampire Exosomes® different from other exosome serums, including dose, NAD support, barrier support, and batch verification.32:25 How Vampire Exosomes® compares to a vampire facial and why topical exosomes work differently.Listen to this episode of Biohacking Beauty to understand what exosomes actually are, what questions to ask before buying an exosome product, and why the source, dose, formula, and proof matter as much as the word “exosome” itself.Find more from Young Goose:Use code PODCAST10 to get 10% OFF your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comYoung Goose Vampire Exosomes® https://www.younggoose.com/products/vampire-exosomesInstagram: @young_goose_skincare
Send us Fan MailI'm back after brain surgery and I'm choosing to come back talking about longevity, beauty, and the quality of life we all deserve. James Stroll joins me to explain why living longer is becoming mainstream, why access may widen over time, and why a longer life has to mean more than just lasting longer. • James's longevity origin story after losing his grandmother • Why he writes books to keep people in the conversation • How RAADFest and the internet helped longevity explode into the mainstream • Whether longevity is only for wealthy people and how prices can drop over time • NAD protocols, gene therapy, and the “early adopter” technology curve • The question nobody can dodge: who are you at 125 • Moving from survival mode into creativity and building “heaven on earth” • What “gospel” means as “good news” and why he uses spiritual language • How spiritual resilience and anti-aging science can support the same goal • Why he wants people to have a real choice about lifespan and healthspan If you'd like the podcast or video cast to go somewhere, you know, Rotarianpod at gmail.com. Of course, I always tell you tell others about the show so they can join in on all the fun. And, you know, if you know somebody that I should know about, again, same address, Rotarianpod at gmail.com. Support the showJoin me as I talk to those "amazing people turning their Actions 2 Impact all over the world. #BE THE CHANGE
Welcome to Quick Hits — where we bring you the most impactful moments from past episodes in under 15 minutes. Today's clip comes from one of our most replayed conversations. If you want the full episode, check the link in the description below. Listen to the full episode Listen on iTunes What actually works when it comes to anti-aging skincare, and what is simply expensive marketing in a very attractive bottle? In this quick hits clip Karen sits down with Amitay Eshel, co-founder and CEO of Young Goose. Amitay explains why effective anti-aging skincare is about much more than moisturizing the surface of the skin. Healthy, resilient skin depends on cellular energy, mitochondrial function, ingredient stability, internal hydration, damage repair and the skin's ability to respond to stress. We also explore how common skincare ingredients such as vitamin C, hyaluronic acid, retinol, NAD, NMN, collagen and spermidine actually work, along with why stronger treatments are not always better. If your bathroom cabinet is overflowing with products but your skin is still dry, dull, irritated or changing rapidly during menopause, this conversation will help you understand what your skin may actually need. In The Full Episode, You'll Learn How vitamin C and hyaluronic acid influence skin rejuvenation Why the stability of vitamin C matters as much as the ingredient itself Why topical skincare cannot fully compensate for poor internal hydration How mitochondrial health affects skin quality and muscle strength How cellular energy influences the skin's ability to repair damage Why stronger concentrations of retinol are not always more effective How skincare ingredients can degrade before they ever reach your skin Why encapsulation is used to protect sensitive ingredients such as NMN How collagen and NAD work differently when ingested versus applied topically Why spermidine is being studied and used in advanced skincare formulas How menopause affects collagen, hydration, pigmentation and skin resilience Why personalized skincare is more effective than following a generic routine When laser resurfacing may be helpful Why frequent aggressive treatments may damage the skin barrier How targeted skincare may improve wrinkles, pigmentation and visible aging Get 10% off your order with Young Goose here. Sponsors Get 20% off your Cozy Earth Bed Sheet with coupon code HORMONES Are you in perimenopause or postmenopause and struggling with symptoms—but not getting the support you deserve? At Midlife Solutions, we specialize in hormone optimization for women in midlife. Our all-female clinical team offers telehealth care across all 50 U.S. states, with the ability to prescribe bioidentical estrogen, progesterone, testosterone, and thyroid medication. Book your FREE Hormone Discovery Call Find out what's really driving your symptoms and what your next best steps are. Visit the website: https://karenmartel.com Shop the Midlife Solutions Store Over-the-counter bioidentical hormone creams and oils — no prescription needed. Including: • Progesterone • Estrogen Face Cream • Vaginal Moisturizer and more! Take the Hormone Quiz Discover hidden hormone imbalances that could be driving your symptoms. Get personalized results (and yes, they may surprise you). Women's Peptide Weight Loss Program Clinically guided, hormone-aware weight loss for midlife women. Midlife RESET HRT Program A complete, supportive approach to hormone replacement therapy in midlife. Your host: Karen Martel Certified Hormone Specialist, Transformational Nutrition Coach, & Weight Loss Expert Karen's Facebook Karen's Instagram
It's Just Bodybuilding Podcast collab @ThinkBIGBodybuilding APR Health Solutions Peptides: www.aprhealthsolutions.com - code nyleOptimize HRT Clinic: https://members.optimize-hp.com - code nyleMerch: https://www.aykons.com/nylePlease share this episode if you liked it. To support the podcast, the best cost-free way is to subscribe and please rate the podcast 5* wherever you find your podcasts. Thanks for watching.To be part of any Q&A, follow trensparentpodcast or nylenayga on instagram and watch for Q&A prompts on the story https://www.instagram.com/trensparentpodcast/Huge Supplements (Protein, Pre, Defend Cycle Support, Utilize GDA, Vital, Astragalus, Citrus Bergamot): https://www.hugesupplements.com/discount/NYLESupport code 'nyle' 10% off - proceeds go towards upgrading content productionYoungLA Clothes: https://www.youngla.com/discount/nyleCode ‘nyle' to support the podcastLet's chat about the Podcast:Instagram: https://www.instagram.com/trensparentpodcast/TikTok: https://www.tiktok.com/@transparentpodcastPersonalized Bodybuilding Program: https://www.nylenaygafitness.comRP Hypertrophy Training App: rpstrength.com/nyle (code nyle)00:00:00 Intro00:02:38 Origin Stories: Entering the Bodybuilding World00:08:18 The Stigma: Bodybuilding 20 Years Ago00:10:35 Joining the Dark Side: Our First Cycles00:18:55 What We'd Change About Our Early Cycles00:20:43 The Era of Fake Gear & Underground Labs00:26:30 Winstrol Hairlines & Injection Horrors00:36:29 Old School Simplicity vs. Modern Complexity00:40:27 The Cost of Growth: Is Bodybuilding Pay-to-Win?00:46:07 Cruising, Coming Off & The Clomid Blues00:47:52 Hardcore Training vs. Modern Exercise Science00:59:58 Generic vs. Pharma Grade Growth Hormone01:07:39 Managing Drug Tolerance & Halo Mood Swings01:10:50 Extreme Eating & Bodybuilding Digestion01:12:05 Cycle Titration & Front-Loading Strategies01:18:25 Finding the Pharmacological Sweet Spot01:29:23 Worst Preps & The Danger of Megadosing01:35:12 Misusing Clenbuterol & Ephedrine01:37:02 Mitochondrial Enhancers: SLU-PP-332 & NAD+01:41:26 Peak Week Myths & The Power of Consistency01:47:38 The Wolverine Stack: BPC-157 & TB-50001:54:09 GLP-1 Agonists & Appetite Suppression02:01:48 The Peptide Hype Cycle02:05:50 Top 3 Compounds for the Apocalypse02:11:24 Protecting Kidney & Heart Health02:13:53 Our Favorite Cutting Cycles02:16:15 The Origin of the Pro Wall02:22:03 What the New Generation Does Better02:24:05 How Much Gear Does It Take to Turn Pro?02:27:18 Controlling Hemoglobin & Hematocrit02:30:20 Wildest Bulks & The Lasagna Diet02:35:14 Musical Tangents: The Velvet Underground02:37:13 Co-Host Pet Peeves02:41:07 Dusty's Brotox Protocol02:44:12 The Craziest Cycles We've Ever Heard Of02:46:30 Overrated Bodybuilding Trends02:48:27 Partying vs. Bodybuilding Discipline02:53:05 Final Message to the World
Send us Fan MailA 27 year old woman went to a longevity clinic in the Bronx for an NAD IV drip. Minutes later she was in cardiac arrest. She died a few hours after that. The person who ran the clinic held a medical license from the Dominican Republic, not the United States.Dr. Kevin White talks with Dr. Matt Kaeberlein, a researcher who studies why and how we age, about what that story actually tells us. His answer isn't really about NAD. It's about certainty. Kaeberlein has never seen evidence that NAD infusions help anyone, and the field's founding claim, that NAD declines with age and needs replacing, is now being questioned by the same scientists who study it. Clinics keep selling it with total confidence anyway.That same pattern shows up everywhere they go in this conversation. Kaeberlein now chairs Montana's expanded Right To Try review board, which lets biotech companies test experimental therapies on real patients once they clear a phase one safety bar, outside the usual FDA process. He explains why that could produce safety data the field has never had, and why he'd reject any therapy pitched without a real scientific rationale behind it, no matter how confidently it's sold."You don't want to listen to the people who are telling you with a hundred percent certainty, do this. And by the way, you know, buy my longevity latte." — Matt KaeberleinThey also compare LinAge2, a biological age calculator built from standard bloodwork with decades of mortality data behind it, to the consumer epigenetic age tests sold directly to the public. Kaeberlein's problem with the popular tests has nothing to do with the underlying science. It's that nobody selling them will publish the error bars, so a 20 year gap on your result could mean everything or nothing. You can't run statistics on a number you're not allowed to check.Along the way they cover why rapamycin, the drug most associated with Kaeberlein's name, might not even be his top pick anymore. A company spun out of his lab, Aura Biomedical, has found longevity molecules that also protect against radiation damage. And a new epigenetic instability test from Irena Conboy's company, Generation Lab, measures something closer to biological chaos than biological age.Follow The Daily Apple and leave a review to help more people find the show. Instagram: @KevinWhiteMDYouTube: @KevinWhiteMD Prime Health Associates
A healthy 27-year-old walked into a Bronx wellness center for an NAD+ "longevity infusion" — and was dead within the hour. The man holding the needle wasn't licensed to practice medicine anywhere in the US. Robert Lufkin MD breaks down the Elizabeth Baron case: what actually happened, what NAD+ can and can't do based on the real evidence, why the billion-dollar med spa industry operates like the Wild West, and the three-license checklist that can protect you before anyone puts a needle in your arm.Chapters:00:00 — Introduction: Death After an Anti-Aging IV Drip00:44 — What Happened in the Bronx: The Elizabeth Baron Case01:58 — What's Actually in the Bag: NAD+ Explained02:56 — No Randomized Trial Evidence for IV NAD+03:38 — The Wild West: Inside the Unregulated Med Spa Boom04:02 — A Pattern of Med Spa Deaths and Injuries04:54 — The Three Licenses: Person, Building, Bottle06:19 — The Honest Caveat: Cause of Death Still Pending07:17 — The Takeaway: Fundamentals Beat the DripKey takeaways:NAD+ is real biology — a coenzyme central to energy production and DNA repair — but no randomized trial has ever shown an IV NAD+ drip slows aging in humans.IV NAD+ is legal yet not FDA approved for any specific application, and the marketing has sprinted far ahead of the evidence.An IV bypasses every natural checkpoint in your body. Treat it like surgery on your blood.Before any injection or infusion, verify three licenses: the person, the building, and the bottle. If a clinic can't answer instantly, walk out.The fundamentals that actually move healthspan — muscle, metabolic health, sleep, blood pressure, blood sugar — cost almost nothing and have mountains of evidence.Sources & reporting:NY Daily News — Bronx clinic death and arrestNY Post — arraignment coverageArina Cadariu MD, MPH — "Nobody Is Counting"NY Post — inside the unregulated med spa industryNewser — case roundupCBS News New York — the three licenses
Are you spending money on NAD+ precursors, IV drips, or cold plunges only to remain chronically fatigued? In Episode 191 of the Inflammation Nation Podcast, Dr. Steven Noseworthy dissects why high-tech biohacking shortcuts fail complex cases, why basic energy balance and calorie deficits are often overlooked, and the pathobiology behind the Cell Danger Response (CDR) and the pyruvate bottleneck.Key Topics Covered:- Too Simple, Often Overlooked: Why energy balance, caloric deficits, and iron-deficiency anemias must be evaluated before advanced protocols.- The Cell Danger Response (CDR): How mitochondria intentionally shift out of ATP production and into biological self-defense when sensing oxidative stress, heavy metals, or stealth infections (like EBV).- The Pyruvate Bottleneck: Why impaired Pyruvate Dehydrogenase (PDH) enzyme kinetics force cells to shunt fuel into anaerobic lactate, driving post-exertional muscle soreness, brain fog, and exercise intolerance.- Perfusion & Glutathione Buffers: Why forcing ATP synthesis in an oxygen-deprived or glutathione-depleted environment generates unbuffered free radicals and causes post-exertional crashes.- The Bioenergetic Restoration Hierarchy: The step-by-step clinical framework to safely unblock metabolic capacity and rebuild resilience.Chapters00:00 Introduction to Fatigue and Biohacking03:02 Understanding Fatigue and Its Complexity06:32 The Cell Danger Response and Mitochondrial Fatigue07:54 Too Simple, Often Overlooked: Calorie Balance and Anemia10:14 Pyruvate Blockade and Energy Production17:45 Physiological Obstacles in Chronic Fatigue32:49 Strategic Framework for Addressing Chronic FatigueWork Directly with Dr. Noseworthy:Request a Private 1-on-1 Discovery Consultation over Zoom:https://www.drnoseworthy.com/contact#ChronicFatigue #Hypothyroid #Mitochondria #NAD #MetabolicHealth #PostExertionalMalaise #FunctionalMedicine #RootCauseMedicine #InflammationNation
MAPS BOGO: https://mapsbogo.com Buy one get one free — mix and match any of the top 10 most popular programs (Anabolic, Aesthetic, Performance, 15 Minutes, Anywhere, Symmetry, Starter, Muscle Mommy, Powerlift, 40+) for $157. In this episode the guys break down exactly how women over 30 can lose fat and build the body they actually want. They cover why the methods that worked in your 20s are no longer effective, why life stress is actually the biggest enemy (not age), and why building muscle and getting stronger is the single thing that changes everything. They walk through the three key steps — feeding the gains with whole foods and enough calories, making strength the goal rather than the scale or the mirror, and replacing cardio with walking — and back it all up with real client stories including a woman running 25 miles a week and lifting 5 days a week who was stuck at 24% body fat, and how Adam helped Katrina achieve the best body of her life eating 700-800 more calories than ever while doing zero cardio. MAPS BOGO: https://mapsbogo.com Recommended combo for this episode: MAPS Muscle Mommy followed by MAPS Powerlift — buy one get one free for $157. SPONSORS Rho Nutrition (liposomal NAD+ and Glutathione): https://www.rhonutrition.com/discount/MINDPUMP Code: MINDPUMP for 20% off everything. Liposomal delivery means it actually absorbs vs. standard capsules. LINKS Mind Pump Store: https://mindpumpstore.com Maps Fitness Products: https://mapsfitnessproducts.com Instagram: @mindpumpmedia SPOTIFY TIMESTAMPS 0:00 - Intro 2:18 - How women over 30 can lose fat and build the body they actually want 2:37 - Why the old methods stopped working — it's not age, it's accumulated stress 4:40 - The real enemy: more stress, more responsibilities, less time and worse sleep 7:14 - Why the methods that worked in your 20s were never actually effective long term 11:02 - The one thing that makes the biggest difference — building muscle and getting stronger 13:48 - Why muscle shifts your metabolism, hormones and insulin sensitivity in your favor 16:03 - Step 1: Feed the gains — why eating more whole food is non-negotiable 20:47 - Step 2: Make strength your goal — the specific lifts that move the needle most 22:25 - Step 3: No cardio — why walking beats running for body composition 24:39 - Why walking beats cardio for women managing high stress loads 25:36 - Client story: woman running 25 miles a week, stuck at 24% body fat — what happened next 27:35 - Katrina's story — best body of her life on zero cardio and 700 more calories a day 30:32 - MAPS Muscle Mommy and MAPS Powerlift — the best 6-month combo for this approach
What happened to all those Balance of Nature commercials we used to hear? What are the pros and cons of male circumcision? Do women wearing thongs get more vaginal infections? Controversy over statins for seniors; An avocado a day may keep the cardiologist away; Major study flags frailty risks with GLP-1 drugs for seniors; Unlicensed doctor arrested after patient dies following NAD+ infusion; Short video “reels” may harm brain centers responsible for attention, executive function.
"If you don't get those foundational behaviors down, there ain't nothing a peptide's gonna do for you,” says Rachele Pojednic, Ph.D. Pojednic is a professor of Sports Nutrition and Exercise Physiology at Stanford University and is the Chief Science Officer at Restore. Her work examines nutrition, supplementation and physical activity interventions on muscle physiology, performance and recovery, as well as muscle related chronic disease, with a particular focus on women. Pojednic holds a Certified Strength and Conditioning Specialist (CSCS) certification from National Strength and Conditioning Association (NSCA) and is board certified Health Coach from the National Board of Health and Wellness Coaches (NBHWC). She has a particular passion for science communication and has been a consultant and writer for many prominent news outlets, including NPR, Time, The Washington Post, and Popular Science. Show notes: 00:00 - The difference between science & wellness 06:30 - The big vs. little levers of health 08:40 - What we do & don't know about peptides 11:45 - A study on supplement stacking gone wrong 13:55 - Next-gen peptides (BPC-157 & more) 18:20 - All about NAD, NR, & NMN 29:57 - Creatine for muscle & brain health 33:48 - Looking at leucine & amino acid profile in protein 36:48 - Why fasting advice for women often backfires 40:24 - Stop chasing perfection 43:45 - How to use wearables & lab testing 50:13 - Bridging science & wellness Referenced in the episode: For more about Pojednic, visit her website: https://www.rachelepojednic.com/ mindbodygreen's creatine brain supplement: https://shop.mindbodygreen.com/products/creatine-brain mindbodygreen's whey protein: https://shop.mindbodygreen.com/products/clear-whey-protein We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices
To Support the work of Apologia -Our newest sponsor is Dominion Wealth Strategists! -Get the NAD treatment Jeff is on, go to Ion Layer and put “IONAPOLOGIA” into the coupon code and get $100 off your first three months! -Check out Amtac Blades and use code APOLOGIA in the check out for 5% off! -You can get in touch with Heritage Defense and use coupon code “APOLOGIA” to get your first month free! -For some Presip Blend Coffee Check out our Store. -Check out the Ezra Institute
Our kidneys do an incredible job filtering our blood every hour of every day. Most of us have two kidneys, and each one has about a million microscopic filters called glomeruli. Unlike the filters in our HVAC system, though, these filters cannot be replaced. But they do their work so well and unobtrusively that most of us don't even think about our kidney function. Although 37 million Americans have kidney trouble, the majority are unaware of their situation. Two tests could reveal how well the kidneys are working. What are they, and how often should you ask about them? At The People's Pharmacy, we strive to bring you up‑to‑date, rigorously researched insights and conversations about health, medicine, wellness and health policies and health systems. While these conversations intend to offer insight and perspective, the content is provided solely for informational and educational purposes. Please consult your healthcare provider before making any changes to your medical care or treatment. How You Can Listen You could listen through your local public radio station or get the live stream at 7 am EST on Saturday, August 8, 2026, through your computer or smart phone (wunc.org). Here is a link so you can find which stations carry our broadcast. If you can't listen to the broadcast, you may wish to hear the podcast later. You can subscribe through your favorite podcast provider, download the mp3 using the link at the bottom of the page, or listen to the stream on this post starting on August 10, 2026. What Are the Two Tests That Reveal Kidney Trouble? Chronic conditions like high blood pressure and diabetes put a strain on the kidneys. They are very common problems that signal the need for kidney function monitoring. Our guest expert, Dr. Samir Parikh, suggests that all of us should know our numbers. One is derived from the level of creatinine in the blood. This is normally part of a basic metabolic panel. Usually, the panel results will include a number for the estimated glomerular filtration rate (EGFR) calculated from the value for blood creatinine. The other crucial test is a urine test for protein. Keeping Kidneys Healthy by Staying Properly Hydrated One of the simplest tactics to keep kidneys healthy is to provide them with enough liquid. We get some fluid from the food we eat, which may be one reason eating fruits and vegetables seems to be good for us. They are full of water! We also need to drink fluid, and plain water is probably the best choice. It would be smart to use thirst as a guideline and make sure to drink when thirsty. We do avoid overdoing water consumption, though, as overloading the kidneys with more fluid than they can handle is dangerous as well. Medicines That Are Hard on the Kidneys We mentioned to Dr. Parikh the experience of an older friend, a devoted runner, who discovered that taking ibuprofen after a run reduced the likelihood of having to get up overnight to urinate. He reminded us and our listeners that nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, naproxen, celecoxib or meloxicam can be hard on the kidneys. That doesn't mean we shouldn't ever take such pain relievers, but perhaps we should try not to make it a habit. When we asked about other medicines that might be tough on the kidneys, he mentioned PPIs. Proton pump inhibitors such as omeprazole (Prilosec) or esomeprazole (Nexium) are often used to treat heartburn or other digestive symptoms. Regular use can put a strain on the kidneys, although the gastroenterologist recommending the medicine might not warn you of that side effect. We asked about environmental toxins and learned that heavy metals such as lead or arsenic can harm the kidneys along with other organs. We should make sure that the food we eat and the water we drink are not contaminated with such compounds. The Possible Benefits of Vitamin B Dr. Parikh has been studying how the kidneys respond to the B vitamin nicotinamide. The preliminary work he and his colleagues have done so far is promising. However, they have not conducted clinical trials to find out whether the vitamin could help people with early kidney disease. Because kidneys work so hard, they need a lot of energy to be produced by the mitochondria in their cells. Those mitochondria need NAD+ (nicotinamide adenine dinucleotide) to function at their best. Providing additional nicotinamide appears to help (Nature Reviews. Nephrology, Feb. 2020). One to three grams a day appears to be safe and may be beneficial. Medications That Can Promote Kidney Health Some medicines initially developed for other conditions are proving to be helpful in treating kidney disease. In particular, these include diabetes drugs known as SGLT2 inhibitors like dapagliflozin (Farxiga) or empagliflozin (Jardiance). They help slow the decline of kidney function (New England Journal of Medicine, Nov. 4, 2022). GLP-1 agonists may also be familiar because they too are used to treat diabetes. Medications such as semaglutide (Ozempic, Rybelsus, Wegovy) and tirzepatide (Mounjaro, Zepbound) have made headlines as weight loss and diabetes meds, but they also can reduce the risk of kidney failure and other bad outcomes (Lancet. Diabetes & Endocrinology, Jan. 2025). The benefits of these types of drugs should give us hope that we can go from slowing the progression of kidney disease to stopping it in its tracks Taking Care of Your Kidneys We asked Dr. Parikh what we should be doing to care for our kidneys and keep them healthy. He urged us once again to know our numbers: most importantly, the numbers from the two tests we discussed, blood creatinine and urine protein. Other numbers that are important for kidney are our blood pressure and, for those with diabetes, HbA1c. In addition to paying attention to all those numbers, we need to embrace a lifestyle that will help keep them where they belong. That means following a heart-healthy diet, staying physically active and getting adequate sleep. This Week’s Guest Samir M. Parikh, M.D., FASN, is Professor of Internal Medicine and Pharmacology and Chair of Internal Medicine at the University of Texas Southwestern. He holds the Donald W. Seldin Distinguished Chair in Internal Medicine and the Ruth W. and Milton P. Levy, Sr., Chair in Molecular Nephrology. Dr. Samir Parikh, University of Texas Southwestern Listen to the Podcast The podcast of this program will be available Monday, August 10, 2026, after broadcast on Aug. 8. This week's podcast has additional information on a possible role for sodium bicarbonate (baking soda) for kidney function. We also discussed medical silos, and how that leads to gastroenterologists overlooking the kidney risks from PPIs. Also, what should prospective kidney donors consider? You can stream the show from this site and download the podcast for free. Download the mp3, or listen to the podcast on Apple Podcasts or Spotify.
What's the difference between hard-hitting marketing and misleading pricing claims? In this episode, we unpack a recent NAD decision involving Harry's and Gillette that explores the boundaries of comparative advertising, including when advertisers can rely on regular retail prices instead of temporary promotional discounts and how far they can go with aggressive language like “you're getting ripped off.” The decision reinforces that comparative pricing claims must be grounded in prices consumers regularly pay, while also signaling that sharp, hyperbolic rhetoric may be permissible when it doesn't cross the line into false or misleading advertising. For brands engaged in competitive marketing, the case offers valuable guidance on striking the right balance between persuasive messaging and legal compliance. Hosted by Simone Roach. Based on a blog post by Gonzalo E. Mon.
I'm a biohacker with a peptide fridge, and right now I am injecting absolutely nothing. That is probably not what you expected me to say. The internet makes it look like the goal is more compounds, stacked higher, forever. It is not. The goal is to use the right tool for a specific window, then come off it. In this solo episode I open my actual fridge. I walk through every peptide I have run recently, the real dose, why it went in, why it came out, and why I am on a full break right now. I cover my injury repair pair BPC-157 and TB-500, my body composition experiments with AOD-9604 and a Retatrutide microdose, my beauty and longevity layer with GHK-Cu and NAD nasal spray, and my brain and mood pair Selank and Semax. Then I explain why I am cycled off everything, and how to build your own stack for a female body instead of copying mine. This is my personal experience for education, not medical advice, and peptides are provider territory. If you want me to help you build and sequence your own stack around your goals and your labs, you can book a free call here. Join The LongHer Life Longevity Community for women-specific guidance on peptides, hormones, and longevity. Timestamps: 02:20 - The confession: a biohacker with a peptide fridge, injecting nothing right now 02:55 - Why more is not better, and who is really selling you peptides forever 04:04 - Work with me one on one: free 15-minute calls for women worldwide 05:11 - Foundations first: hitting 140 g of protein a day and creatine 06:39 - Two years postpartum, building muscle, and my genetics 07:57 - Sleep and recovery: my new Oura Ring and tracking HRV 08:43 - Where my peptide year started: a wake surfing knee injury 09:35 - BPC-157: how it works, my dose, and doubling it to heal my knee 11:17 - Who BPC-157 is for, injecting near the injury, and breastfeeding 12:41 - TB-500: the classic repair partner, my loading dose, and tapering off 13:58 - Body composition peptides: AOD-9604 and Retatrutide microdosing 14:25 - AOD-9604: gentle fat metabolism, my 300 mcg fasted dose, who it suits 18:46 - Retatrutide explained: the triple agonist people call GLP-3 22:25 - Why I would buy Retatrutide now and store it in your fridge 24:56 - Serious weight loss vs my 0.5 mg microdose, and the nausea I felt 28:02 - The GLP muscle and nutrient warning every woman needs to hear 29:18 - GHK-Cu: the copper beauty peptide for skin, hair, and nails 30:47 - Managing the GHK-Cu skin reaction, and when to take a break 32:24 - NAD nasal spray: energy, focus, and longevity the gentle way 35:22 - Selank: my favorite calming peptide for anxiety and stress 37:45 - Semax: the focus peptide, and how I pair the two 39:04 - Why I am cycled off everything right now: the full deload 43:53 - How to build your own stack without copying mine 44:38 - Labs and supplements I am running: SiPhox, Function Health, Needed 45:44 - Start gentle, stay at 3 to 5 peptides, and cycle off 46:27 - Free peptide sources and my digital peptide planner 48:18 - Close: work with me, and why the break is the protocol Resources: Work with me one-on-one: book a free 15-minute call. The Her Stack Planner to track your doses, timing, and cycles. My Peptide Source Guide with vetted sources for Canada, the US, and global, plus supplies. Join The LongHer Life Longevity Community. Products mentioned: AgelessRx for the NAD nasal spray and GHK-Cu cream. Code: BIOHACKINGBRITTANY. SiPhox Health at-home blood testing in Canada. Code: BRITTANY20. NiaHealth at-home labs in Canada. Function Health labs in the US. Needed prenatals and omegas. Code: BIOHACKINGBRITTANY. Oura Ring for sleep and HRV tracking. Let's connect: Instagram and TikTok @biohackingbrittany, and Facebook. Shop everything I use at biohackingbrittany.com. Listen on Spotify, Apple Podcasts, and YouTube Music. This is for educational purposes only. This is not medical advice.
Connect with us via text! The future of skin care is being shaped by ingredients that promise everything from cellular repair to regenerative results, but which ones are truly worth the hype? This week we welcome Michael Q. Pugliese, third-generation CEO of Circadia, accomplished skin care formulator, and award-winning educator, to break down the emerging ingredients and technologies redefining professional aesthetics. From PDRN, exosomes, NAD+, and 5-ALA to the growing focus on skin resilience, recovery, and circadian biology, Michael separates science from speculation while sharing the trends every professional should have on their radar before they become mainstream.Follow DERMASCOPE:Instagram: @dermascopeFacebook: facebook.com/dermascopePinterest: @dermascopeTikTok: @dermascopeYoutube: @dermascopeFollow Michael:Instagram: @pugliese.michaelFollow Circadia:Instagram: @circadiaFacebook: facebook.com/circadiaAdditional Links:Visit our website.Learn more about this podcast.Subscribe to the magazine.Read the August 2026 issue.
First, let's break down what BPC-157 actually is. BPC stands for Body Protection Compound, and the 157 refers to the specific amino acid sequence that makes up this peptide. It's a synthetic peptide derived from a protein found in our stomach, specifically in gastric juice. This peptide has been shown to have a range of healing properties, particularly related to tissues like the gut, muscles, and tendons. The reason BPC-157 is getting attention in the realm of acid reflux and gastrointestinal issues is because of its potent regenerative abilities. Some studies suggest it could promote healing in the gastrointestinal tract, reduce inflammation, and improve the gut barrier—key factors for people dealing with acid reflux. Read the Full Episode Transcript: https://pepties.com/acid-reflux-relief-with-bpc/ Related Links/Products Mentioned: Peptide Podcast Partners Page https://pepties.com/partners/ Buy Peptides online at BioLongevity Labs: Use our link and enter COUPON CODE: PEPTIDEPODCAST at checkout to receive 15% off your total order: https://go.biolongevitylabs.com/SH5C Momentous Supplements (we use Creatine, Vital Aminos, Whey Protein) https://crrnt.app/MOME/OqGQOxGA LMNT – More Salt, Not Less. https://elementallabs.refr.cc/default/u/johnjavit Thorne Supplements (we use Omega-3 with CoQ10, Red Yeast Rice, Zinc) https://get.aspr.app/SH1KvW Organifi Creatine and Shilajit Gummies http://rwrd.io/rlbkajm?c MitoZen (methylene blue for Cognitive Function, Anti-Aging, Mental Clarity) https://www.mitozen.com/ref/cnlwiztypt/ For skin and hair health (Copper Tripeptide-1) Visit Luminose by Entera for an exclusive offer for Peptide Podcast listeners! ** Promo code PEPTIDEPODCAST at checkout for 10% off an order or 10% off the first month of a subscribe-and-save. ** https://www.enteraskincare.com/?rfsn=8906839.f93c72 NAD+ Push Patch: https://www.pushpatch.com/
How does a skin scientist evaluate a worth-it product? What ingredients are too good to be true? This week, we're partnering with our friends at Parëva Beauty to learn the answers to these questions directly from the founder Smitha Rao — a scientist who's spent nearly two decades formulating over 200 products for brands like StriVectin and Olaplex before launching her own line. Smitha breaks down what's actually happening with buzzy ingredients like exosomes and NAD+, what “clinically proven” really means, and the informed difference between anti-aging and skin longevity.Tune in to hear:What biotech skincare actually means, and why Smitha says “the future is biology, not chemistry”How exosomes work to help skin regenerate its own collagen — and why not all exosome technologies are created equalNAD+ and NMN, decoded: why you keep seeing these phrases pop-up on skincare labelsThe questions to ask before trusting any “clinically proven” claim The biggest mistake even savvy INCI-label readers make when building a routine, according to SmithaSmitha's take on the ingredients having a moment that she's most skeptical ofAn inside look at Parëva's latest launch, the GFP12 Collagen Eye Serum
What can you actually do to support your egg quality before your next IVF cycle? I'm honored to share this s episode of IVF In Your Pocket, hosted by Alexandra Geary-Stock where we go over my whole-body approach to egg quality, from supplements and rapamycin to red light therapy, ovarian PRP, and yes, even EDM music. Whether you're just starting to try to conceive or gearing up for your next embryo transfer, I think you'll loave this episode because we're talking about practical, accessible steps you can start today. In this episode, we cover: Dr. Aimee's head-to-toe framework for supporting egg quality (mental health, sleep, nutrition, relationships, uterine health, exercise) Why "support" egg quality is a better mindset than "improve" it Reducing microplastic exposure in everyday products Her go-to supplement stack: OVA NAD+ and CoQ10 (and why less is more) Using rapamycin as an anti-aging aid for egg quality Peptides, growth hormone, and GLP-1 for body inflammation Red light therapy and ovarian PRP explained Dr. Aimee's top 5 accessible tips to support egg quality Resources: Read the full show notes on Dr. Aimee's website Find Alexandra Geary-Stock's therapy practice and podcast (IVF in Your Pocket) here. Do you have questions about IVF? Click here to join Dr. Aimee for The IVF Class. The next live class call is on Monday, August 17th at 4pm PST, where Dr. Aimee will explain IVF and there will be time to ask her your questions live on Zoom. Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org. Other ways to connect with Dr. Aimee and The Egg Whisperer Show: Subscribe to my YouTube channel for more fertility tips!Subscribe to the newsletter to get updates Related Phrases egg quality, supporting egg quality, IVF tips, Dr. Aimee, Egg Whisperer, fertility doctor, OVA NAD, CoQ10, rapamycin, egg quality supplements, ovarian PRP, red light therapy, peptides for fertility, GLP-1 fertility, NAD infusions, microplastics fertility, embryo quality, euploid embryo, IVF cycle prep, trying to conceive tips
In this episode, Dr. Tony breaks down the Cell Danger Response, the research behind why a child's cells shut down energy production, and why that shutdown is actually the nervous system doing exactly what it's designed to do when it senses ongoing threat. He explains why supplements, red light therapy, and NAD+ can feed the cell the raw materials for energy, but none of it holds if the nervous system is still stuck broadcasting danger.You'll learn about the three stages of subluxation, why an upper cervical brainstem subluxation can send a global distress signal to every cell in the body, and why movement, the neurosensory motor system, and the exhausted cerebellum are quietly draining more energy than anything else. This is the missing piece in the mitochondria, microbiome, and methylation conversation: movement.-----Links & Resources:Register for the free Breaking the Cycle of School Struggles Webinar HERE-----Key Topics & Timestamps: 00:00 Why the mitochondrial energy conversation is missing something 02:00 What Dr. Tony sees in every Perfect Storm case history 07:00 Why exhausted kids collapse instead of moving through the world 11:00 What the research says about the brain, mitochondria, and autism 13:00 The real question: not how to make more energy, but where it's going 20:00 What is the Cell Danger Response? 22:00 The three stages of subluxation and nervous system dysregulation 24:00 Why supplements and red light therapy don't hold without this fix 29:00 The missing "M word": movement, proprioception, and the cerebellum 36:00 How INSiGHT Scans and neurospinal EMG find the root cause-- Follow us on Socials: Instagram: @pxdocsFacebook: Dr. Tony Ebel & The PX Docs NetworkYoutube: The PX DocsFor more information, visit PXDocs.com to read informative articles about the power of Neurologically-Focused Chiropractic Care.Find a PX Doc Office near me: PX DOCS DirectoryTo watch Dr. Tony's 30 min Perfect Storm Webinar: Click Here
Ivana Korčoka platí Progresívne Slovensko. To Slováci vedeli a nebol dôvod to skrývať. Prečo však bývalý minister potrebuje dostávať peniaze za svoju činnosť cez manželkinu eseročku, z ktorej nedávno vystúpil? Na stole je otázka transparentnosti financovania príjmov zo straníckych peňazí – alebo ako hovoria v Smere v prípade Michala Fica – transformácie štátnych peňazí. O manželkách, partnerkách a rodinných príslušníkoch, za ktorých sa skrývajú politici, a o netransparentnom vyplácaní peňazí pre Ivana Korčoka sa s moderátorkou podcastu Dobré ráno Janou Krescanko Dibákovou rozprávala spolupracovníčka Nadácie Zastavme korupciu Xénia Makarová. Zdroje zvukov: Youtube/Denník N, Youtube/Progresívne Slovensko, Markíza, Facebook/Ján Mažgút Odporúčanie: Každý víkend sa na Slovensku hrajú stovky futbalových zápasov. Viete, kedy a kde nastúpi mužstvo z vášho mesta či dediny? Špeciálna príloha s kompletným vyžrebovaním jesennej časti futbalových súťaží. Od Niké ligy po šiestu ligu. Už dnes v denníkoch SME a Korzár. – Všetky podcasty denníka SME nájdete na sme.sk/podcasty – Odoberajte aj audio verziu denného newslettra SME.sk s najdôležitejšími správami na sme.sk/brifingSee omnystudio.com/listener for privacy information.
Here is the link for the event in Illinois on August 4th, 2026 To Support the work of Apologia -Our newest sponsor is Dominion Wealth Strategists! -Get the NAD treatment Jeff is on, go to Ion Layer and put “IONAPOLOGIA” into the coupon code and get $100 off your first three months! -Check out Amtac Blades and use code APOLOGIA in the check out for 5% off! -You can get in touch with Heritage Defense and use coupon code “APOLOGIA” to get your first month free! -For some Presip Blend Coffee Check out our Store. -Check out the Ezra Institute
What if the fatigue, poor sleep, and slow healing you've chalked up to "just getting older" actually trace back to one molecule you stopped making enough of at 40? Melatonin isn't just a sleep aid. It's your mitochondria's master antioxidant, and its levels fall off a cliff right when you need it most. In today's episode, Dr. John Lieurance joins me to break down why that drop matters so much for energy, detox, and brain health. He shares the research behind super-physiological melatonin dosing, why suppositories outperform oral and IV delivery, and how melatonin clears heavy metals from the brain. We talk about his health crisis, root causes of enlarged prostate, and the peptides he uses for skin and tissue repair. We also dig into mold detox, craniosacral therapy, and heart rate variability as a longevity marker. "400 times more melatonin is secreted by the lining of your gut, triggering microbiome swarming that stimulates the good bacteria to proliferate and inhibit the bad bacteria." ~ Dr. John Lieurance In This Episode: - Addressing prostate inflammation at the Advanced Rejuvenation clinic - Mitochondrial stress from endogenous and exogenous toxins - Airways, dura and the glymphatic system - Fascia, acupuncture and frequency medicine - The Warburg effect and melatonin intersect - How melatonin supports heavy metal detoxification - Melatonin and Heart Rate Variability (HRV) - Health benefits of MitoSkin and GHK-Cu Copper - Mold toxicity and detox strategies Products & Resources Mentioned: Dr. John Lieurance's Book: Melatonin Miracle Molecule: https://a.co/d/04I0Zc2L MitoZen Supplements: Science-backed supplements for NAD+, sleep, immune support, cellular energy, and detoxification: https://www.mitozen.com/ Fresh-Pressed Olive Oil: Try a full-size $39 bottle for just $1 to cover shipping at https://getfreshwendy.com Tru Energy Skincare Bio Adaptive Hydration Oil: Try the oil and save up to $197 at trytruenergy.com/wendy5 Organifi Collagen: Save 20% with code MYERSDETOX at https://organifi.com/myersdetox Heavy Metals Quiz: Check your toxicity score and receive a free video series on how to detox your body. Take the quiz at https://heavymetalsquiz.com About Dr. John Lieurance: Dr. John A. Lieurance, ND, DC, DABCN, is a Sarasota-based naturopathic physician, chiropractic neurologist, author, and educator with nearly 30 years of experience in functional medicine, regenerative medicine, and neurological care. He is the founder of Advanced Rejuvenation and serves as Scientific Advisor and Chief Formulator for MitoZen Scientific, where he focuses on mitochondrial health, advanced delivery systems, melatonin, NAD+, and methylene blue. Dr. Lieurance is widely known for his work with Functional Cranial Release, regenerative therapies, and his research-driven approach to supporting cellular energy, brain health, and whole-body vitality. You can learn more about his work at https://www.advancedrejuvenation.us/ and buy his supplement line at https://www.mitozen.com/ Disclaimer The Myers Detox Podcast was created and hosted by Dr. Wendy Myers. This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast, including Wendy Myers and the producers, disclaims responsibility for any possible adverse effects from using the information contained herein. The opinions of guests are their own, and this podcast does not endorse or accept responsibility for statements made by guests. This podcast does not make any representations or warranties about guests' qualifications or credibility. Individuals on this podcast may have a direct or indirect financial interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.
We're living in truly crazy times, and things that would not even be remotely controversial ten years ago now bring ire to certain parts of society. A while ago, the idea of Christopher Nolan filming an adaptation of THE ODYSSEY would bring universal interest, but now any perceived ""woke" decision brings multitudes of vitriol and "discourse".Today we take a look at this film on it's own merits, and see how a myth that has evolved through centuries is recontextualized for our day and age. Join us as we aura farm with Agamemnon and take a journey with Odysseus to Ithaca as we encounter war, trauma, acceptance, and forgiveness on 70mm IMAX (none of us saw it on this format). • • •TRIAD Of The FORCE is a STAR WARS+ podcast hosted by Gus, Nani, Nad, & Chase—Puerto Rican and queer creators sharing deep dives, and heartfelt conversations from a galaxy far, far away. Featured on the STAR WARS CELEBRATION Podcast Stage (2022 & 2023), we explore STAR WARS, fantasy, comic books, and other POP-culture media honestly. We engage in inclusive commentary across film, TV, books, comics, and beyond with humor, critical analysis, and cultural perspective (without the toxicity).Follow TRIAD Of The FORCE at:BlueSky: https://bsky.app/profile/triadoftheforce.bsky.socialInstagram: https://www.instagram.com/triadoftheforce/YouTube: https://www.youtube.com/c/TriadoftheForce/If you like us, get some merch and help the channel:TeePublic: https://www.teepublic.com/user/triad-of-the-force• • •Acknowledgement: The Intro and Outro music is the Triad of the Force Theme, composed and performed by Grushkov with full permission for use by Grushkov (https://linktr.ee/Grushkov).• • •This channel is not affiliated in any way with Lucasfilm Ltd. LLC, The Walt Disney Company, or any of their affiliates or subsidiaries.
Another day, another press conference with very few answers about the weekend shooting in Seattle. Guest: Chris Elder is a 20-year Navy veteran running for Washington's 44th Legislative District. // Guest: Michelle Bennett is Mercer Island’s police chief but now she’s running for Washington’s 5th Legislative District. // Guest: UW Professor Matt Kaeberlein discusses the health benefits of NAD+ supplements.
Here is the link for the event in Illinois on August 4th, 2026 To Support the work of Apologia -Our newest sponsor is Dominion Wealth Strategists! -Get the NAD treatment Jeff is on, go to Ion Layer and put “IONAPOLOGIA” into the coupon code and get $100 off your first three months! -Check out Amtac Blades and use code APOLOGIA in the check out for 5% off! -You can get in touch with Heritage Defense and use coupon code “APOLOGIA” to get your first month free! -For some Presip Blend Coffee Check out our Store. -Check out the Ezra Institute
In this episode the guys break down how to reverse osteopenia and osteoporosis — explaining the difference between the two, why 43% of adults over 50 have low bone mass, and why this is actually very fixable. They cover the four key steps: getting stronger (not just lifting weights), eating enough to build, taking key nutrients like calcium, vitamin D and magnesium, and being consistent because bone adapts more slowly than muscle. They also discuss why GLP-1 users are showing up with osteopenia and why it's not the drug's fault, Sal's experience with Rho Nutrition's liposomal curcumin and why it's dramatically reducing his jiu jitsu inflammation, Adam's deep dive into the solar panel scam with PG&E buying his energy at $0.08 and selling it back at $0.48, creatine accelerating recovery from brain injuries and concussions in kids, protein Doritos macro breakdown, noninvasive brain stimulation improving explosive power, AI agents buying robot dogs for themselves, and whether Dune or Star Wars came first. Then they coach live callers submitted through mplivecaller.com. MAPS Upper Lower: https://mapsupperlower.com Code: LAUNCH for 40% off. Male and female programs, workout videos, exercise demos and live coaching with Cole. Mind Pump Fitness Coaching: https://mindpumpfitnesscoaching.com 1.9 NASM CEUs SPONSORS Rho Nutrition (liposomal curcumin, NAD+ and Glutathione): https://www.rhonutrition.com/discount/MINDPUMP Code: MINDPUMP for 20% off everything. Sal discusses the liposomal curcumin on air — dramatic reduction in jiu jitsu inflammation within 4 days. Liposomal delivery is the key difference. Zbiotics Pre-Alcohol: https://zbiotics.com/MINDPUMP26 Code: MINDPUMP26 for 15% off first purchase. World's first genetically engineered probiotic. Breaks down acetaldehyde in the gut before it causes issues. Discussed on air — now available at Bev Mo. Butcher Box: https://butcherbox.com/mindpump No code needed. Free ribeyes for a year, or free ground beef or chicken breasts in every order for life, plus $20 off first box. LINKS Submit a live caller question: https://mplivecaller.com Mind Pump Store: https://mindpumpstore.com Maps Fitness Products: https://mapsfitnessproducts.com Instagram: @mindpumpmedia 0:00 - Intro 2:14 - How to reverse osteopenia and osteoporosis — why it's more fixable than people think 4:55 - Who gets this — not just the elderly, also fit people who under-eat 12:11 - Step 1: Get stronger — why lifting weights without getting stronger does nothing for bones 15:46 - Step 2: Eat to build — why GLP-1 users are showing up with osteopenia and why it's not the drug's fault 20:00 - Step 3: Key nutrients — calcium, vitamin D and magnesium and why supplements alone won't fix it 22:27 - Step 4: Be consistent — bones adapt slower than muscle, 1-2% gain per year is a big win 24:13 - Rho Nutrition liposomal curcumin — Sal's jiu jitsu inflammation gone in 4 days 26:35 - Adam's solar panel PG&E rage — buying energy at $0.08 and selling it back at $0.48 43:27 - Creatine and brain injury recovery — children's concussion study shows dramatic improvement 47:33 - Protein Doritos macro breakdown and the creatine cereal prediction 51:38 - Noninvasive brain stimulation improves explosive power — no exercise required 56:01 - AI agents buying robot dogs for themselves — Tony Robbins story 59:24 - Did Dune or Star Wars come first? The sci fi rabbit hole 1:03:03 - Caller: Derek (California) 60 day check-in — 5 pounds gained, bench up 30 pounds, gets MAPS Upper Lower 1:16:18 - Caller: Beth (Georgia) — 59-year-old NFL exec, too lean, over-exercising, needs to eat more and slow down 1:30:31 - Caller: Liz (Ohio) — Birthday caller, bike tripper, wants to gain muscle, gets Muscle Mommy 1:43:08 - Caller: Kimberly (Minnesota) — professor, runner, feels bulky on top, gets coaching referral
Why Oral and IV Glutathione Never Actually Reach Your Cells (The Delivery Breakthrough Changing Everything) Most of the supplements you're taking aren't failing you, they're failing to ever reach the cells that need them, and almost nobody selling them wants you to know that. This episode hands you the delivery breakthrough that actually gets it there. Use code DAVE for a discount at aurowellness.com/dave Host Dave Asprey sits down with Dr. Nayan Patel, a pharmacist, researcher, and founder of Auro Wellness, whose work centers on solving one of biohacking's most stubborn problems: getting nutrients past the bloodstream and into the cells that actually need them. He holds 14 patents in delivery technology, partners in the high-end longevity clinic Unlimited Life, and has spent over two decades studying glutathione, the master antioxidant his own research helped bring into modern biohacking. Dave and Dr. Patel break down a 2011 University of Texas study showing that oral and liposomal glutathione are completely broken down into raw amino acids before absorption, meaning none of it reaches the bloodstream as glutathione, a pattern that holds true even for IV administration. They dig into new brain-imaging research showing topical glutathione crossing into neural tissue within 20 minutes, why senescent "zombie cells" may be directly tied to glutathione shortfalls, and why NAD, despite its reputation as the ultimate longevity molecule, is actually dependent on glutathione to do its job. They also cover the real purity ceiling on GHK-copper peptides, safe upper limits for glycine and NAC before they start working against you, a topical alcohol protocol that clears acetaldehyde without triggering a breathalyzer, and why oxidative stress from GLP-1 use is quietly driving one of the drug class's least-discussed side effects. You'll Learn: Why oral, liposomal, and even IV glutathione never actually reach your cells intact, and what a 2011 UT study proved about it How topical glutathione was shown to cross into brain tissue within 20 minutes, and what that means for neurological aging Why senescent "zombie cells" may be directly linked to glutathione shortfalls, and how one longevity clinic reversed markers by 70% in a year Why NAD isn't the "ultimate longevity drug" it's marketed as, and its actual dependent relationship with glutathione The real purity ceiling on GHK-copper peptides, and why 73% is currently the best available anywhere Safe upper limits for glycine and NAC, and the oxalate crystal and Parkinson's-like risks of overdoing either one A topical alcohol protocol that clears acetaldehyde fast enough to beat a breathalyzer Why GLP-1 drugs are quietly driving oxidative stress, and what most patients are missing to counter it Thank you to our sponsors! - PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off. - OneSkin | Get 15% off OneSkin with the code DAVE at https://www.oneskin.co/DAVE #oneskinpod - Caldera + Lab | A small habit with big results. Go to CalderaLab.com/DAVE and use code DAVE for 20% off your first order. - Fatty15 is on a mission to support Healthy Aging for All, including all ages and stages of life. You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com and using code DAVE at checkout Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: glutathione, Nayan Patel, Ora Wellness, glutathione absorption, transdermal delivery, senescent cells, zombie cells, cellular aging, GHK-copper peptide, NAD, NAD supplements, NAC, glycine, GlyNAC, oxalate crystals, alcohol metabolism, acetaldehyde, GLP-1, semaglutide, oxidative stress, heavy metal detox, mercury toxicity, BPC-157, biohacking, longevity, functional medicine Resources: • Get A Discount On Auro Wellness Products - Use code DAVE: aurowellness.com/dave • Learn More About Dr. Patel's work at: http://aurowellness.com/dave• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:43 – Episode Intro 03:16 – Glutathione Basics 07:34 – Senescent Cells 11:07 – Cellular Delivery Science 14:20 – GlyNAC Precursors 21:37 – Amino Acid Ratios 25:18 – GHK Copper Peptide 28:41 – Purity & Manufacturing 31:34 – Glutathione vs. NAD 33:49 – Absorption Studies 37:51 – Heavy Metals & Toxins 42:35 – Alcohol & Glutathione 47:43 – Mortality & Reincarnation 49:54 – GLP-1s & Anhedonia 53:25 – Future of Peptides See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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