Podcasts about NAD

My guest this week is Amitay Eshel, the co-founder, and CEO of Young Goose, the biohacking skincare brand. After serving in leading roles in Israel's special forces community, he has held executive roles in the health, wellness, and beauty industry for over a decade.  Young Goose embodies his two passions, performance optimization, and skin health, with products that boost the functions of natural rejuvenation processes in the skin. We're discussing anti-aging, biohacking for the skin and whole body, and red light therapy.  Guest Offer: Save 20% on your purchase of Young Goose SkinCare:  http://bit.ly/YOUNGGOOSE20 Code: SUPERHUMAN20 Follow Amitay https://www.instagram.com/young_goose_skincare https://www.younggoose.com/   Sponsor: Thanks to our Episode Sponsor BiOptimizers. BiOptimizers make the only full-spectrum and most bioavailable Magnesium Supplement on the market called Magnesium Breakthrough – I use it every day and every night for brain benefits, to optimize my sleep, and much more. This month is also when they are offering huge discounts and free products on all qualifying orders! Just use my exclusive link: www.magnesiumbreakthrough.com/bionat and use discount code "bionat" to stock up and SAVE! That's www.magnesiumbreakthrough.com/bionat with promo code “bionat”   Show Notes: [04:30] How do you go from Green Beret to Red Light Therapy to Skincare line? .. [11:00] Can you look younger without optimizing your overall health?.. [19:15] Light therapy for anti-aging, longevity, medical purposes and more… [32:25] Red light masks for anti-aging… [37:00] Can red light affect the infrastructure underneath the skin?.. [41:05] Red light therapy for the brain and gut… [49:45] Red light for hair growth… [56:45] Let's talk about skincare… [62:15] NAD for health and skin… [73:40] Talking more about ingredients.. Chamomile to downregulate CD38.. Using fermented resveratrol, a polyphenol, and antioxidant. Ghk-cu for glycation and more… [79:30] Should all GHK-cu products be blue to be effective?.. [81:34] How do you figure out what products you should and shouldn't trust?.. [85:06] What results should we expect from skincare as far as a reversal of skin damage?.. [86:55] Damaging the skin in order to remodel your skin.. Is there a limit to the number of procedures you can do for improvement?.. [93:03] What is in the face mask that Amitay gave Nathalie?..

‘Learn to live with your pain.' How many times have you heard this statement? For people with chronic pain, this is common but unhelpful advice. Pain is more than just mechanical damage. Context and the expectations you have around it play a significant role in how you experience pain. Remember, it's possible to recover from pain. But you must be aware of the proper chronic pain treatment. Pain expert Dr Kal Fried joins us in this episode to discuss how pain is more complicated than we think. If we want to recover from pain, we must first understand how it works. He also shares the role of medication and lifestyle changes and how chronic pain treatments work differently for each person. What's important is to become active and involved in your recovery process. If you want to learn more about chronic pain treatment and how to break free from chronic pain, this episode is for you.  Here are three reasons why you should listen to the full episode: Learn how pain works and why it's more complicated than just a mechanical function of your body.  Understand how we can deal with and recover from pain through lifestyle changes and other chronic pain treatments.  Discover the importance of taking charge of your healing and recovery.  Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron!  A new programme, BOOSTCAMP, is coming this September to Peak Wellness! Pain Revolution  Programmes that came out from Pain Revolution: Brain Changer | Permission to Move  Exsurgo  Explain Pain by David Butler and Lorimer Moseley Connect with Dr Kal: Website | The Rehabilitation Medicine Group | Phone: +613 9555 7769 | Fax: +613 8738 1504 | Email     Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/. Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, Run Longer  Without Burnout & Injuries Have you struggled to fit in training in your busy life? Maybe you don't know where to start, or perhaps you have done a few races but keep having motivation or injury troubles? Do you want to beat last year's time or finish at the front of the pack? Want to run your first 5-km or run a 100-miler? ​​Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle?  Go to www.runninghotcoaching.com for our online run training coaching. Health Optimisation and Life Coaching If you are struggling with a health issue and need people who look outside the square and are connected to some of the greatest science and health minds in the world, then reach out to us at support@lisatamati.com, we can jump on a call to see if we are a good fit for you. If you have a big challenge ahead, are dealing with adversity or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, contact us at support@lisatamati.com. Order My Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Still, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books. Lisa's Anti-Ageing and Longevity Supplements  NMN: Nicotinamide Mononucleotide, an NAD+ precursor Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, is being dramatically decreased over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. Founded by scientists, NMN Bio offers supplements of the highest purity and rigorously tested by an independent, third party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful third party tested, NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of aging while designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health My  ‘Fierce' Sports Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection. Episode Highlights [04:10] Dr Kal's Career Dr Kal is trained as a sports and exercise physician. He oversees the medical needs of athletes and regular people.  Through his work and experience, he observed that the severity of injuries could not predict the outcome. There were cases of minor injuries leading to terrible outcomes and vice versa.  These experiences led him to learn more about the science of pain and work with the organisation Pain Revolution.   [06:52] Why Pain is Complicated We're taught that pain is mechanical. But, bodies do not produce pain, per se.  The body only produces electrical signals that our sensory nerves pick up.  Your pain response is dependent on how much danger your brain thinks you're in.  Injuries are not always proportionate to pain. Pain has physical, contextual and sociological contributing factors.  Listen to the full episode to hear two stories about people who ignored — and created! — pain based on their circumstances! [13:42] How Pain Works  Pain is more complicated than we think. Thresholds don't explain pain completely either.  Your context plays a significant role in how you perceive and experience pain. There are other factors that contribute to you experiencing more pain, such as stress, living through a pandemic, your beliefs and expectations.   [14:52] Responding to Pain Lisa shares how there are various kinds of pain in her life. These include the changes women undergo at different times in their cycles.  Learn to accept that there is a lot involved with pain. Understanding and acceptance will help you change your pain response. Pain can become a habit. Injuries create a direct channel to the brain, which can remain even after someone's body heals. This is called sensitisation. While there are medications designed to stop this direct channel, the best method is to develop habits for desensitising this pain pathway.   [21:09] The Role of Distractions and Neurotransmitters  We often experience higher levels of pain at night because nothing distracts us from the pain. This then leads to sleep deprivation and fatigue, creating a cycle of pain.  People naturally develop intuitive strategies like distracting themselves from pain.  You can transform your pain experience by manipulating your neurotransmitters through a re-adaptive program.  Through this process, you change people's thoughts and actions.  [23:51] Medication is Not Always the Answer for Chronic Pain Treatment The brain naturally contains morphine-like chemicals.   Pain medication doesn't work for everyone. Some people are pain-sensitive and medication-resistant.  Too much medication can also lead to addiction and negatively impact your health.  [28:50] The Hardships of People with Chronic Pain People find it easier to empathise with those whose sicknesses are visible.  People with chronic pain often end up in a vicious cycle of social breakdown because there's little understanding and compassion for the condition.  Not only that, pain makes people more irritable.  [31:06] Options for Chronic Pain Treatment Meditation as a chronic pain treatment is slowly becoming more mainstream in the medical profession.  One method will not work for everyone as people relate to different things. It's vital to build an individualised program for chronic pain treatment or management.  Remember that pain is not harmful. It's just a protective mechanism.  It's common to hear that we need to learn to live with the pain, but this may not be effective for everyone.  Tune in to the full episode to hear Dr Kal talk about his work with Pain Revolution and the graded exposure program.  [34:56] Find What Works for You  It's difficult for doctors to understand your situation and condition fully. It would be best for you to take charge of your health by doing your research.  Question treatments and methods. Don't blindly accept answers.  However, when you start to read online resources, you also need to be wary of false information.  Be careful how you interpret science and research.   [44:01] Seeking Science-Backed Treatments Your health is an interconnected system. Pain can be a signal for many things.  Become more involved in your health; start with lifestyle changes.  Be careful with placebo treatments. There are cases where sugar pills seem to work because the brain believes that they will.  Placebo treatments' effectiveness will wane eventually and lead people to seek more aggressive types of interventions.    What's most important is understanding what methods work, their benefits and safety concerns before applying anything. [47:24] The Pain Revolution Approach Learn how pain works. There are a lot of reliable resources available that you can consult.  Pain Revolution has an annual outreach cycling tour. They also have a two-year course for local pain educators. Dr Kal hopes for the community to grow and focus on non-interventional techniques for chronic pain treatment. Know that you can adapt to pain. There is a way to recover.     7 Powerful Quotes ‘I like to think of pain in terms of not causes but contributors. The physical side is important… but it's only one contribution of many.' ‘By just getting people to conceptualise their pain properly, we can make a difference.' ‘The best model exists for understanding pain is that anytime we feel pain, or for that matter, all the sensations we feel, which are essentially produced by our brain, there are a lot of things going on at the same time.' ‘When pain persists, it takes a lot less contribution from the physical component to produce the same pain. Sometimes, no contribution at all and people remain in pain.' ‘I think the key thing is to try and avoid being too passive in your own health because reliance on external fixes can be a problem. A lot can be achieved by lifestyle changes.' ‘The people who do well in things like pain or recovery from injuries are often the people who have elected not to listen to the things they have been told.'  ‘If you've got a problem, you just need to create that adaptation pathway for yourself, which doesn't just involve the injury.' About Dr Kal Dr Kal Fried is a proud member and Medical Director of Pain Revolution. Before being recruited, he was involved in the group's first Rural Outreach Tour in 2017. Dr Kal is an independent medico-legal examiner who has consulted with the Transport Accident Commission and WorkSafe as a medical advisor. He was admitted as a Fellow of the Australian College of Sports and Exercise Physicians in 1995. Ever since then, he's helped sporting teams at all levels and across disciplines.  From his experience, Dr Kal observed how the context of pain consistently predicted clinical outcomes. He often shares his findings and observations on pain science and chronic pain treatment on his website. He is also part of the Rehabilitation Medicine Group focused on creating re-adaptive programs for people in pain.  Interested to learn more about Dr Kal's work? Check out his website. You can also reach him on The Rehabilitation Medicine Group through phone (+613 9555 7769), fax (+613 8738 1504), and email.        Enjoyed This Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can learn more about pain and chronic pain treatment.  Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa The information contained in this show is not medical advice it is for educational purposes only and the opinions of guests are not the views of the show. Please seed your own medical advice from a registered medical professional

Le Book Club a désormais son livre ! Dans “Une bibliothèque féministe”, ouvrage collectif co-écrit par Agathe Le Taillandier et co-édité par l'Iconoclaste et Louie Media, 18 féministes qui incarnent nos féminismes contemporains racontent le livre féministe qui a changé leur vie. Adèle Haenel, Nadège Beausson-Diagne, Laura Nsafou, Mélissa Laveaux, Titiou Lecoq, Geneviève Fraisse, Rebecca Zlotowski, Marie Desplechin, Assa Traoré, Fatima Daas, Morgane Ortin, Camille Froidevaux-Metterie, Alice Coffin, Rebecca Amsellem, Pénélope Bagieu, Nina Bouraoui, Alice Zeniter, Laure Adler. Elles tournent avec Agathe les pages de leurs titres incontournables du féminisme. On navigue ainsi de Despentes à Audre Lorde en passant par Virginia Woolf et Alison Bechdel. "Une Bibliothèque féministe" est disponible en librairie ou en ligne comme sur le site de notre partenaire LesLibraires.fr, le portail de la librairie indépendante. À s'offrir pour enrichir votre propre bibliothèque, ou celles des personnes autour de vous ! Voir Acast.com/privacy pour les informations sur la vie privée et l'opt-out.

Dr Thomas Levy is a cardiologist and a lawyer and author of more than 13 books including his latest "Rapid Virus Recovery." In this podcast, we discuss ways to boost our immunity and protect ourselves from viruses. Our bodies are more capable than we think. If it has the correct nutrients, the human body can simultaneously recover from viruses and/or protect itself from them. We just need to make sure that we are supporting its innate abilities and Dr Levy gives us a list of things we can do to protect ourselves. He also shares that clinical recovery is often different from true recovery. Studies suggest that 40% of the novel virus-positive patients retain the virus — even after they think they've recovered!  If you want to learn more about how to achieve true recovery from disease and protect yourself, then this episode is for you! Here are three reasons why you should listen to the full episode: Understand how supporting your body's natural abilities, supported by vitamin C and hydrogen peroxide nebulisation, lead to true recovery from diseases.  Discover the concept of pathogen colonisation, where you may be clinically well but still harbor pathogens.  Learn why vaccines have side effects and what they do in your body.    Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron!  Episode 167: Curing the Incurable with Vitamin C with Dr Thomas Levy MD, JD   Get Dr Thomas Levy's books https://www.peakenergy.com/books.php and be sure to check out Rapid Virus Recovery  Download the Hidden Epidemic E-Book for free! Get Magnesium: Reversing Disease also for free download Free Download! Get Death By Calcium Canceling the Spike Protein - Striking Visual Evidence Hydrogen Peroxide Nebulization and Virus Resolution - Impressive Anecdotal Results Learn more about Dr Paul Marik's protocol for sepsis using vitamin C and steroids.  Check out this study published on the International Society for Orthomolecular Medicine about comparing levels of ascorbic acid in plasma and white blood cells from vitamin C supplementation with hydrocortisone.       Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/.   Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, Run Longer  Without Burnout & Injuries Have you struggled to fit in training in your busy life? Maybe you don't know where to start, or perhaps you have done a few races but keep having motivation or injury troubles? Do you want to beat last year's time or finish at the front of the pack? Want to run your first 5-km or run a 100-miler? ​​Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle?  Go to www.runninghotcoaching.com for our online run training coaching.   Health Optimisation and Life Coaching Are you struggling with a health issue and need people who look outside the square and are connected to some of the greatest science and health minds in the world? Then reach out to us at support@lisatamati.com, we can jump on a call to see if we are a good fit for you. If you have a big challenge ahead, are dealing with adversity or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, contact us at support@lisatamati.com.   Order My Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Still, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books.   Lisa's Anti-Ageing and Longevity Supplements  NMN: Nicotinamide Mononucleotide, an NAD+ precursor Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, is being dramatically decreased over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. Founded by scientists, NMN Bio offers supplements of the highest purity and rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful third-party tested NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of aging while designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health   My  ‘Fierce' Sports Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection.   Episode Highlights [02:22] Dr Thomas' Latest Book, Rapid Virus Recovery  Before the pandemic, Dr Thomas had been researching Vitamin C and hydrogen peroxide nebulisation.  He found that hydrogen peroxide is a natural product that the human body already produces in large amounts. The epithelial cells that line your lung airways produce hydrogen peroxide that acts as anti-pathogens.  In addition, the human body converts up to 5% of the oxygen you inhale into hydrogen peroxide. Dr Thomas shares that people can achieve a true recovery from the virus so much faster when we optimise our body's ability to protect and heal itself.  [06:37] Clinical Recovery Is Not True Recovery   The healthcare industry focuses on treatment methods that generate profit — hospitalisation, medication, therapy, and intubation. Even if you clinically get better from the virus, it does not mean that you have eliminated it from your body.   40% of novel virus positive patients become sick even after they recover from an acute episode.  All diseases involve excess oxidation, which stimulates the growth of new pathogens and toxins in your gut and cells.  [10:35] Is Hydrogen Peroxide Dangerous?  Hydrogen peroxide can kill pathogens both inside and outside the body.  Remember that many prescription drugs can be toxic when applied inappropriately and with the wrong dosage and concentration.  When nebulising 3% hydrogen peroxide, you can raise your blood oxygen level by 3% in around 1 minute.  Listen to the full episode to hear how a woman in Colombia treated twenty of twenty patients with advanced infection of the novel virus successfully in just five days!  [15:09] Don't Be Afraid, Let Your Body Heal Itself Don't be afraid of the novel virus — you can address it using easily-accessible methods.  Hydrogen peroxide nebulisation is not just for novel viruses — it can also help treat cancers. Dr Thomas shares how it can normalise the gut and cure tumours in the full episode. Cancers are caused by excess oxidative stress, which leads to chronic pathogen colonisation.  When you give your body more oxygen and nutrients, you give it the chance to heal itself. Utilise hydrogen peroxide nebulisation, hyperbaric oxygen treatments, and even vitamin C!  [24:40] How Vitamin C Works With Hydrogen Peroxide It's vital to remember to balance the effects of what you take — there are cases when you want pro-oxidant substances, like Vitamin C.  Dr Thomas shares that taking large amounts of Vitamin C can help the hydrogen peroxide break down.  This combination then leads to an oxidative effect that kills pathogens  Vitamin C can also produce more peroxide from which cells can mobilise iron. This iron then further supports the way Vitamin C and hydrogen peroxide work together.  Listen to the full episode to hear the in-depth explanation of how Vitamin C, hydrogen peroxide, and iron all work together.  [30:43] How Iron Works  All pathogens, cancers, and infections accumulate iron. The more iron you have, the more it can fuel pathogens.  However, iron key links can bring cancers and infections under control.  For people with too much iron, also called hemochromatosis, you can manage and mobilise iron levels with vitamin C therapies.  [33:37] Vitamin C Is Essential for Health Remember that inflammation means high oxidation levels in certain areas, which causes a depletion of Vitamin C.  Your body will fight against this inflammation using its antioxidants.  Dr Thomas argues that the immune system is all about supplying antioxidants in the form of Vitamin C.  If your cells, like macrophages, can't do their job due to a lack of Vitamin C, then you can help boost its cell absorption by combining a low dose of hydrocortisone with vitamin C.  [37:30] Vitamin C Can Also Be Used to Cure Sepsis  Dr Thomas shares that curing sepsis can be as easy as taking 12.5 to 25 grams of Vitamin C every six hours.  When you have high cortisol levels due to sepsis, you don't need to use cortisone.  You need Vitamin C to reduce the oxidised receptors and normalise your cortisol.  Cortisone is beneficial for those who have had their adrenal glands removed and can no longer produce cortisol on their own. [42:03] Vaccine Side Effects   Many vaccines use spike proteins instead of an inactivated virus, hoping to create antibodies to protect against the virus.  However, the spike protein can replicate on its own and, in many cases, be a toxin itself.  Different side effects often depend on the spike protein's binding site. For example, when it binds to the vascular endothelial, it can lead to blood clots.  Remember that once a pathogen enters and colonises your body, it will linger unless you eliminate them all. You can treat viruses, vaccine side effects, and even fungal infections with vitamin C and hydrogen peroxide.  [51:08] What Happens In The Body When There Are Spike Proteins  It's logical to think that having a lot of spike proteins in your body may deny the natural function of cells and their H2 receptors.  Side effects are not just dependent on spike protein's binding site — it can also be people's area of susceptibility to increased oxidative stress.  [55:00] How The Pandemic Will End  This pandemic can end faster when more people achieve true recovery using hydrogen peroxide nebulisation.  When people are afraid, they listen to only one narrative.  Take ownership of your health and figure out what's best for you   7 Powerful Quotes ‘Here's something that just about killed my extremely healthy 50-year-old best friend, and when is it going to hit me? So I understand the fear. However, you should understand... you don't have to have that fear because we have the information and the techniques to deal with it across the board.' ‘The healthcare industry is not the slightest bit interested in spending millions of dollars on research on something that will generate them nothing. Quite the contrary to generating nothing, it will take money out of their pocket and take away prolonged expensive hospitalisations, and antibiotics and intubations, and you name it.' ‘Actually, it shouldn't come as a surprise because your body has a mechanism if you support that mechanism for dealing with killing any pathogen you encounter. I mean, if the body didn't have that, we'd all be dead and we would have never survived as a species'. ‘If you don't do the legwork, and study for yourself, and figure out what's best for you, but instead, just walk into the doctor's office and say, “Here's my warm body, do whatever you think is best”, it's only you that's going to suffer.' ‘If you have a physician that doesn't have the time or inclination to talk with you and discuss things that you want clarification on, don't walk — run out of that office!' ‘Unless you have a specific biofilm-dissolving pathogen-killing intervention, such as hydrogen peroxide, but it's not the only thing that will do that, you're going to keep that colonisation for life. And this is why people have bowel disorders for life.' ‘Not everybody has that ability to do that or their willingness to do that. But you have to take responsibility for yourself. Nobody else can take that away from you. You really do have to put in the hard yards.'   About Dr Thomas Levy Dr Thomas Levy is a board-certified cardiologist and a bar-certified attorney. After practising adult cardiology for 15 years, he began to research the enormous toxicity associated with much dental work, as well as the pronounced ability of properly administered vitamin C to neutralise this toxicity. He has now written 11 books. Several of them address the wide-ranging benefits of Vitamin C and its capacity to neutralise toxins and resolve most infections, as well as its vital role in the effective treatment of heart disease and cancer. Others tackle the essential roles of dental toxicity and nutrition in disease and health. Recently inducted into the Orthomolecular Medicine Hall of Fame, Dr Levy continues to research the impact of the orthomolecular application of vitamin C and antioxidants in general on chronic degenerative diseases. His ongoing research involves documenting that all diseases are different forms and degrees of focal scurvy arising from increased oxidative stress, especially intracellular. Furthermore, they all benefit from protocols that optimise the antioxidant levels in the body.  He regularly gives lectures on this information at medical conferences around the world. If you want to learn more from Dr Levy, you may contact him at televymd@yahoo.com or through his website.    Enjoyed This Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you were inspired to do your hard yards, then leave us a review. You can also share this with your family and friends so they too can find true recovery from diseases. Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. The information contained in this show is not medical advice it is for educational purposes only and the opinions of guests are not the views of the show. Please seed your own medical advice from a registered medical professional. To pushing the limits, Lisa The information contained in this show is not medical advice it is for educational purposes only and the opinions of guests are not the views of the show. Please seed your own medical advice from a registered medical professional  

Please join authors Babken Asatryan and Anwar Chahal, and Associate Editor Ntobeko Ntusi as they discuss the Primer article "Inflammation and Immune Response in Arrhythmogenic Cardiomyopathy: State-of-the-Art Review." Dr. Carolyn Lam: Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the journal and its editors. We're your co-hosts, I'm Dr. Carolyn Lam, associate editor from the National Heart Center and Duke National University of Singapore. Dr. Greg Hundley: And I'm Dr. Greg Hundley, associate editor, director of the Pauley Heart Center at VCU Health at Richmond, Virginia. Well, Carolyn this week, our feature discussion, we're not going to go with one of our original articles, but we are going to feature a primer and a primer is a state of the art review article. The topic is going to be on arrhythmogenic cardiomyopathy and we'll be looking at the role of inflammation and the immune response in arrhythmogenic cardiomyopathy. But before we get to that feature, how about we grab a cup of coffee and talk about some of the other articles in the issue? Would you like to go first? Dr. Carolyn Lam: I would, because guess what? I'm going to be talking about prescription opioids. We know these are a major contributor to the ongoing epidemic of persistent opioid use. What do you think is the incidence after cardiac implantable electronic device procedures? Greg, let's start with a Greg Hundley quiz. I'll give you multiple choice, how about that? Do you think it is 1%, 10%, 25%. 50%? Dr. Greg Hundley: All right, Carolyn, I'm going to guess here. I'm going to go 10%. Dr. Carolyn Lam: Smart. Well, guess what? Today's paper actually gives us insight into that question, it's from Dr. Frankel from the hospital of the university of Pennsylvania and his colleagues, and these authors performed a retrospective cohort study using data from a national Administrative Claims Database from 2004 to 2018 of patients undergoing cardiac implantable electronic device procedures. Adult patients were included if they were opioid naive during the 180 day period before the procedure and did not undergo another procedure with anesthesia in the following 180 days. Dr. Carolyn Lam: Persistent opioid use, which is what we're interested in, was defined by filling an additional opioid prescription more than 30 days following the procedure. So, here's your answer. Of the more than 143,000 patients meeting these inclusion criteria, 11%, so you were right Greg, 11% filled an opioid prescription within 14 days of surgery. Among these patients, persistent opioid use occurred in 12.4% of patients, 30 to 180 days after surgery. The likelihood for developing persistent opioid use was increased for patients who had a history of drug abuse, pre-operative muscle relaxant or benzodiazepine use or opioid use in the prior five years. Also, patients who have prescribed more than 135 milligrams of oral morphine equivalence had a significantly increased risk of persistent opioid use. Dr. Carolyn Lam: Now, this is important because all physicians who perform cardiac implantable electronic device procedures and care for these patients should be aware of the risk of persistent opioid use. This is discussing in editorial by Dr. Kandil from UT Southwestern. Dr. Greg Hundley: Very interesting Carolyn, so connecting sometimes the prescription use of opioids after cardiac implantable electronic devices. Great presentation. Well, my first paper comes to us from the world of preclinical science and it's from our prior editor in chief Dr. Joseph Loscalzo from Brigham and Women's Hospital and the Harvard Medical School. So Carolyn, interferon gamma, producing CD4 positive and CD8 positive T-lymphocytes, have been identified as the predominant pathological cell subsets in human atherosclerotic plaques. Dr. Greg Hundley: While the immunological consequences of these cells have been extensively evaluated, their interferon gamma mediated metabolic effects on endothelial cells remains unknown. So Carolyn, the purpose of this study was to determine the metabolic consequences of the T-lymphocyte cytokine interferon gamma on human coronary artery endothelial cells. Dr. Carolyn Lam: Interesting. So what did Dr. Loscalzo and colleagues find? Dr. Greg Hundley: Right, Carolyn. So, the authors found that interferon gamma impairs endothelial glucose metabolism via altered tryptophan metabolism while depleting NAD plus, which results in a metabolic shift toward increased fatty acid oxidation, and therefore, Carolyn, this work suggests a novel mechanistic basis for pathologic T-lymphocyte endothelial interactions in atherosclerosis, mediated by interferon gamma, linking endothelial glucose, tryptophan, and fatty acid metabolism with NADH and ATP generation and their adverse endothelial functional consequences. Dr. Carolyn Lam: Oh, very nice, Greg. Thank you. The next paper describes a comprehensive characterization of cardiomyopathy caused by filament C truncating variance. Dr. Greg Hundley: Whoa. Okay, Carolyn. Now what is filamin-C? Dr. Carolyn Lam: I thought you may ask and I wasn't going to quiz you, see Greg? The filamin-C gene can cause a striated muscle protein that crosslinks actin and anchors cell membrane proteins to the cytoskeleton, sarcolemmal and sarcomere Z-disc. So, the co-corresponding authors of today's paper Drs. Mestroni and Taylor from University of Colorado, Denver Anschutz Medical Campus, analyzed longitudinal clinical data from an international multicenter cohort of 85 carriers of this filamin-C truncating variants. And this is what they found. Dr. Carolyn Lam: First, the cardiomyopathy associated with filimin-C truncating variants appeared to be a disease with heterogeneous phenotypic presentation, ranging from typical dilated cardiomyopathy to arrhythmogenic, right ventricular cardiomyopathy, and with frequently overlapping forms. Dr. Carolyn Lam: Number two, left ventricular ejection fraction was associated with the risk of death, either all cause or non-arrhythmic, heart transplantation, or LVAD, but not with the risk of sudden cardiac death or major ventricular arrhythmias, highlighting the need for alternative strategies of stratification of the arrhythmic risk in these patients with the filimin-C truncating variant cardiomyopathy. Dr. Carolyn Lam: And number three, this cardiomyopathy was associated with a high risk of ventricular arrhythmias with frequencies of life-threatening ventricular arrhythmias, not significantly different from things like Lamin and desmoplakin cardiomyopathy. Dr. Greg Hundley: Well, Carolyn, just fantastic. My next paper comes to us from Professor Lena Claesson-Welsh from Uppsala University and Carolyn, palmdelphin belongs to the family of paralemmin proteins implicated in cytoskeletal regulation and single nuclide polymorphisms in the palmdelphin locus that result in reduced expression are strong risk factors for development of calcific aortic valve stenosis, and predict the severity of the disease. Dr. Carolyn Lam: Wow, interesting. Palmdelphin, great. So tell us, what did they find and what are the clinical implications please? Dr. Greg Hundley: Right, Carolyn, great question. So first, calcific aortic valves stenosis patients with the single nucleotide polymorphism RS754 3130 express reduce palmdelphin levels in valve endothelial cells, which shows hallmarks of palmdelphin deficiency, such as loss of cytoplasmic RanGAP1, altered nuclear morphology and nuclear rest of P53 of P21. Carolyn, second, gene-regulatory changes affecting actin reorganization, are detected in seemingly healthy regions of calcifying bowels, in agreement with disturbed actin-dependent processes, being an early event, instigating the calcific process. And so Carolyn, the take home message is that palmdelphin is prominently expressed in endothelial cells and the presence of the palmdelphin single nucleotide polymorphism correlated both with a Barrett endothelium and calcific aortic valve stenosis suggesting that endothelial cell dysfunction is essential in development of calcific aortic valve disease. Dr. Carolyn Lam: Oh, wow, wow. Thank you for translating that into the clinical implication. Thanks Greg. Let's maybe discuss what else is in today's issue. There's a prospective piece by Dr. Kirchof entitled “In Patients With Recently Diagnosed Atrial Fibrillation, Think Anticoagulation And Rhythm Control.” There's an exchange of letters between Drs. Liao and Hakala regarding the article Cardiovascular Risk Factor Trajectory Since Childhood And Cognitive Performance In Midlife, The Cardiovascular Risk In Young Finns, study. Dr. Greg Hundley: And Carolyn, I've got a research letter from Professor Ramin entitled “Association Between Sarcomeric Variants In Hypertrophic Cardiomyopathy In Myocardial Oxygenation, Insights From A Novel Oxygen-Sensitive CMR Approach.” Well, how about now we get onto that primer feature discussion relating to arrhythmogenic cardiomyopathy? Dr. Carolyn Lam: Yay. All right, let's go, Greg. Dr. Greg Hundley: Well, listeners, we are now onto our feature discussion and this week we've got a different aspect to the feature discussions. We're going to work through a review article and what we call as a primer. It's one of our state-of-the-art family of publications, where we take a topic and perform a review on a new evolutionary concept that might be occurring in a particular field. This week, we are going to discuss arrhythmogenic cardiomyopathy and we have with us two of the authors of this primer, Dr. Babken Asatryan from Bern, Switzerland and also Dr. Anwar Chahal from Lancaster, Pennsylvania. And of course, as always, we invite one of our associate editors and we have with us this week Ntobeko Ntusi from South Africa. Welcome gentlemen and Babken, let's start with you. Can you give us just a little bit of review regarding arrhythmogenic cardiomyopathy? We hear that term as opposed to arrhythmogenic right ventricular cardiomyopathy, and then maybe also, what are the underlying fundamental histopathologic and pathophysiologic findings associated with this disease? Dr. Babken Asatryan: Thank you, Greg. It's really an absolute pressure being here and thank you for your invitation again. So arrhythmogenic cardiomyopathic is genetically-determined heart disease and the common cause of sudden cardiac death in individuals younger than 40 years of age, it's characterized pathologically by fibrosis and/or fibro fatty infiltration of the myocardium. This infiltration provides a substrate for electrical and stability and leads to ventricular arrhythmias ranging from isolated premature ventricular contractions to sustain ventricular tachycardia and ventricular fibrillation. Live ventricular arrhythmias are cardio manifestations of the orthogenic cardiomyopathy, and they typically occur at early stages of the disease, preceding pathological and functional abnormalities. We call that a concealed stage of the disease. Dr. Babken Asatryan: The typical form for arrhythmogenic cardiomyopathy, which has been previously termed as arrhythmogenic right ventricular cardiomyopathy, primarily affects the right ventricle and has been recognized for decades. Following implementation of postmortem autopsy, increased use of contrast, enhanced cardiac MRI, and improved understanding of the genotype phenotype correlations, more recently cases with more pronounced left ventricular involvement have been discovered as well as cases with biventricular involvement of the disease. Dr. Babken Asatryan: Nowadays, we believe that around 60% of cases have also left ventricular involvement, even if they're diagnosed based on the 2010 task force criteria for arrhythmogenic cardiomyopathy. Causative variants in desmosomal genes are identified in about 60% of patients with typical arrhythmogenic right ventricular cardiomyopathy. Dr. Babken Asatryan: Recently, there have been studies reporting non-desmosomal gene variants in patients with arrhythmogenic right ventricular cardiomyopathy, as well as in those left ventricular and biventricular forms of the disease. But the left ventricular form is quite new to us, so we are learning a lot every day about this disease. Dr. Babken Asatryan: The pathogenesis of this condition appears to be quite complex. We know that these pathogenic variant in desmosomal genes can initiate several pathways and these could be gene dependent. What we do know, that these eventually lead to fibrosis and fibro fatty infiltration of the myocardium, which is the hallmark feature of arrhythmogenic cardiomyopathy. Dr. Greg Hundley: And patients present generally when, in terms of lifespan? Dr. Babken Asatryan: So, patients present in between 30 to 40 years of age, there's a typical presentation for arrhythmogenic cardiomyopathies but young presentations are also common nowadays, particularly. So, programs in families, they usually present 30 to 40 years of age. But in families, we do discover patients who have typical arrhythmogenic right ventricular cardiomyopathy or left and right ventricular involvement were younger at age, but they still need the criteria. Dr. Greg Hundley: And then when we diagnose this condition, do we also need to think about, at least clinically, looking for other affected individuals within a family? Dr. Babken Asatryan: Absolutely. So most of the arrhythmogenic biventricular cardiomyopathy, arrhythmogenic left ventricular cardiomyopathy cases are autosomal dominant diseases. So, this means if an individual carries a pathogenic variant in one of the genes responsible for the condition, the likelihood that the first degree family members will carry the same variant is about 50%. The disease however, presents with reduced penetrance and variable expressivity. Some of the family members may have just arrhythmias and others may develop arrhythmias and structural heart disease. And some of the individuals who carry pathogen occurrence in desmosomal are the genes responsible for the condition may not show phenotype at all. So, that makes the decision-making in families quite challenging. Dr. Greg Hundley: Very nice. Well, thank you so much Babken and now, we're going to turn to one of your co-authors, Anwar and Anwar, in this primer, you start to present a new sort of theme, that inflammation actually may play a role in this disease, at least in terms of adverse events. Can you describe a little bit what your team was thinking here and what took you in this direction and what are some of the research that you've revered here that supports this new line of thinking?   Dr. Anwar Chahal: Thanks, Greg and Ntobeko, for first, the kind invitation to come on this podcast. I must add that I normally listen to the podcast and very much enjoy it, so it's a great honor and privilege for us. Dr. Anwar Chahal: Let me contextualize it, I think it's important to think about what are problems are when we evaluate cases, whether that's the program or the family members, and try to determine what's actually going on. There's been a number of changes over the last 15 years that really evolve around a better understanding and the availability of multimodality imaging, which has altered the way we evaluate these cases. If you look at the 2010 taskforce criteria, for example, they talk about volumetric changes and injection fractions by echo or MRI, and even ventriculogram synapse on fluoroscopy, which I don't think many people do anymore, but they don't mention gadolinium enhancement, and there is an updated version that will come out and talk about that, and the advantages of MRI and even contrast-enhanced CT, and now 18F-FDG, CT PET imaging. Dr. Anwar Chahal: So, the patient journey and the problem that we face is that actually some people present with very unusual features, chest pain, troponin rise, undergo coronary angiography, normal coronary arteries, or unobstructed coronary arteries. We put them through MRI scanners and we see a little bit of gadolinium enhancement. We follow them over the next five years or so, and it develops into taskforce criteria, positive ARVC. So, that's the sort of clinical angle where we've started to see this. Dr. Anwar Chahal: As we put people through scanners, we see the hearts lights up on PET scanners, pretty reproducibly and reliably, that tells us that there's some inflammation there. We look back into the literature and actually very, very early work that was done, autopsy-based, some of it endomyocardial biopsy-based describing lymphocytic infiltrates. Usually that's dry, as you say, or sterile, but there have been reports of even viral pathogens. Dr. Anwar Chahal: That's where it stirred this debate up for us about whether there's this signal that we're seeing there, what is it? What's actually going on? It raises a question, we recognize the other mechanisms, the fiber fatty replacement, the apoptotic pathways, that contribute to that. But there's such variable expressivity with this disease. It's a difficult disease to pin down and it raises a question. What are these other effect modifiers? Is there something else that we do not recognize? And that's really what's driven this. Dr. Anwar Chahal: Our group of co-authors are leaders in the field. Some of them are colleagues in veterinary medicine, Dr. Anna Geltser, and we work together on boxer dog patients. So, she is a practicing vet and a scientist, and has lots of boxer dogs with arrhythmogenic cardiomyopathy. We've been looking at how we could utilize that as a model to test some of the findings that we have in humans and pioneering work really by Bob Hamilton in Toronto, in this paper where they described anti-DSG2 antibodies, which were found not only in humans, whatever the underlying genotype, but also in boxer dogs with arrhythmogenic cardiomyopathy. And that's been followed up with work from Europe, describing anti-heart antibodies, anti-intercalated disk antibodies. Dr. Anwar Chahal: It doesn't really matter what the genotype is, but we're seeing these antibodies there and we're seeing these positive scans indicating inflammation. So the big question is, is this inflammation of primary insult or is it secondary? Is it that the heart in somebody with a genetic cardiomyopathy is predisposed, maybe the remodeling is affected. Bob Hamilton thinks this is probably the best explanation to explain why, whatever the genotype, that these antibodies were positive, that actually that myocardium becomes exposed. The epitope of DSG is now exposed to the immune system, which mounts an antibody response, and hence you see the rise in these antibodies, but it's possible it could it be primary as well. With COVID, and this is a bit of a stretch, so just bear with me there, with COVID we've been recognizing that there's myocardial injury. Dr. Anwar Chahal: There's not as much myocarditis as we expected, but there's been, with virus SARS-CoV-2, we know regular human coronavirus is a recognized cause of viral myocarditis. So, the question really arose are we going to see a lot more of this myocarditis? In our lab discussion, it was, "Well, do you think we're going to see something similar in that we've seen with arrhythmogenic cardiomyopathy, these genetically predisposed individuals are more likely to get invaded? Now, we haven't really seen that with COVID and I won't delve too much into it, but going back to the classical viral infections that we see with myocarditis, here's a really, really interesting biological link. Most of them invade through the desmosome, so with SARS-CoV-2, we see the ACE2 receptors as the way the virus really invades. But with these regular coxsackie virus, for example, parvovirus, a lot of them invade through the desmosome, and that's where we thought, here's a link. Dr. Greg Hundley: Very nice. Ntobeko, you see a lot of papers come across your desk. What attracted you to this group of investigators and this particular review article? Dr. Ntobeko Ntusi: Thank you very much, Greg. I want to start by congratulating Babken, and Anwar for a really fantastic submission, which as an associate editor, was an absolute pleasure to handle. There really are six things that stood out for me about this article. The first one really relates to the question that you ask Babken, which relates to the nomenclature and people have traditionally thought of this is a disease of the right ventricle. I think it's now timely to consider a clear change in nomenclature, that recognizes not only right ventricular involvement, but also left ventricular involvement. And the common finding of biventricular disease in patients with ACM. Dr. Ntobeko Ntusi: The second really important contribution for me from this primer was that we've always thought of arrhythmogenic cardiomyopathies as a genetic disorder with abnormalities in the genes, encoding components of the desmosome. Many groups recently, including our own group that described novel mutations for arrhythmogenic cardiomyopathy in adhering to poultry and other genes outside of the desmosome are showing that the genetic underpinnings are much wider. But the key contribution here is really the consideration of the centrality of inflammation to the pathogenesis of this disease. Anwar has spoken to some length about that, so I won't rehash those comments, but for me, what is key for future work in this area is really to clarify whether the inflammation, as in with many other forms of cardiovascular disease, is merely an epiphenomenon, or whether it plays a critical role in the causal pathway for the phenotypes that we see. Dr. Ntobeko Ntusi: The next important feature for me was the review of the literature and evidence in the association with myocarditis. So, we've seen lots of case reports and small case series showing young people presenting with myocarditis and meeting either the Dallas criteria histologically, or the Lake Louise criteria on imaging, and then subsequent genetic testing confirming the diagnosis of an arrhythmogenic cardiomyopathy. I thought for the first time with quite a compelling review of the link between these two. Dr. Ntobeko Ntusi: The fourth important contribution relates really to the contribution of imaging modalities, both in diagnostics, but critically in risk stratification for this clinical entity. And for me, the importance of cardiovascular magnetic resonance, either with planimetric mapping or late gadolinium enhancement to really add to our ability to predict future events. Dr. Ntobeko Ntusi: Then there's been quite a number of publications in the last five years that have clarified our understanding of the at risk patient with arrhythmogenic cardiomyopathy who's likely to suffer a sudden cardiac death event. This tends to be somebody who was young, who was male, who has a history of documented non-sustained ventricular tachycardia or a history of syncope and on ECG, quite extensive T wave inversion. So again, this is nicely reviewed, and we think about those as candidates who'll benefit from implantation of an ICD. Dr. Ntobeko Ntusi: Then I thought for me, the last really nice contribution from this piece was the review of advancing our understanding of the hot phase. So in all forms of heart muscle disease, we speak of the presentation of patients with the chest pain syndrome, with a troponin leak, but unobstructed coronaries. On further investigation, we don't really find any other evidence of an inflammatory event. We call this a hot phase. And in some case reports in small case series, endomyocardial biopsy has revealed the association of these, whether in TCM, HCM, or arrhythmogenic cardiomyopathy with lymphocytic infiltration. I thought this was all very nicely reviewed. Dr. Ntobeko Ntusi: So, the question that really left me with having read this review, was whether in the future, we may actually need to consider targeting inflammatory pathways as a therapeutic target in this heart muscle disorder. Thanks Greg. Dr. Greg Hundley: Yes. Thanks so much in Ntobeko. You've really led us to the next question that I'm going to ask both Babken and Anwar, you've discussed where do you feel this field is moving and what is the next study or series of studies we need to perform. Babken, first you, and then Anwar. Babken, what do you think is the next study to be performed in this space? Dr. Babken Asatryan: I so much agree with Ntobeko, that perhaps understanding better what can be targeted in these patients, in order to prevent development of phenotype or least to prevent cardiac events, is perhaps the most important next step. In our first figure, we have summarized this potential mechanisms, involving inflammation leading to with arrhythmogenic cardiomyopathy in these patients. We have also highlighted the potential mechanisms that perhaps in the future can be targeted. This could include both targeting the inflammatory cytokines, as well as the primary agents that cause the myocardial inflammation in patients, depending on the results that we will receive over the next years and perhaps animal models should be the next step to better understand how similar arrhythmogenic cardiomyopathy phenotype, where inflammatory contributors to the phenotype are important. And then we can understand whether this can be the same in humans as well. Dr. Greg Hundley: Very nice. And Anwar, do you have anything to add? Dr. Anwar Chahal: Yes. So, agree with that. I guess I would add what are we doing to try to help decipher this? So some of the work that we're doing, I mentioned earlier with the boxer dog patients, who have arrhythmogenic cardiomyopathy. So some of the aspects that we're actually looking at is taking swab cells to see if we can phenotype as a alternative tender myocardial biopsy. And one of the co-authors, Angeliki Asimaki, really pioneered that as a alternative tool because the desmosis are ubiquitous and this may help us phenotype patients better. But also, we want to look at using that as a tool in the pheno copies of arrhythmogenic cardiomyopathy. So we would advocate, re-phenotyping people as well as possible and trying to use some of these techniques. Dr. Anwar Chahal: The next thing we're really looking at is antibody based tools, either working with collaborators, who've already described these antibodies such as anti-DSG2, anti-heart antibody, and anti-skeletal disc to see if we can develop those and perhaps identify others in both human and ox models. And that will then hopefully open the way for us to develop therapeutics that may be able to target those and address that, and maybe use these antibodies as markers to see disease progression, or halting of disease. Dr. Greg Hundley: Very nice. Well listeners, we want to thank Dr. Babken Asatran from Bern, Switzerland, Anwar Chalal from Lancaster, Pennsylvania, and our own associate editor, Ntobeko Ntusi from South Africa, really helping us see this new scientific consideration regarding the potential role of inflammation in causal pathways of adverse manifestations of arrhythmogenic cardiomyopathy. Well, on behalf of Carolyn and myself, we want to wish you a great week and we will catch you next week on the run. This program is copyright of the American Heart Association, 2021. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more visit ahajournals.org.

Are you facing an obstacle that you fear you can't overcome, or a milestone you can't seem to reach? Don't let this emotion trap you; everyone experiences difficulties when starting something new. Face the challenge head-on! Conquering will make you stronger. And what better way to challenge yourself than by running a marathon?   This week, Angie and Trevor Spencer from the Marathon Training Academy join us for a conversation on all things marathon running. They share their experiences about their running journey and the marathoning community they created. Angie discusses how she got into marathoning and how it led to their podcast. They also recount their most memorable marathons and the lessons that they learned along the way. Finally, we learn the value of facing challenges, staying in the present, and paying attention to our overall health.  If you want to overcome life's obstacles and know how to train for a marathon, this episode is for you.    Here are three reasons why you should listen to the full episode: Learn more about Marathon Training Academy and how Angie and Trevor can help you train for a marathon.  Discover how you can keep challenging yourself.  Understand that we're all built differently.    Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron!  Harness the power of NAD and NMN for anti-aging and longevity with NMN Bio.  A new programme, BOOSTCAMP, is coming this September to Peak Wellness!  Listen to my other Pushing the Limits episodes:  #8: Dean Karnazes - The Road to Sparta #183: Sirtuins and NAD Supplements for Longevity with Dr Elena Seranova #189: Understanding Autophagy and Increasing Your Longevity with Dr Elena Seranova Newest Episode with Dean Karnazes  A Runner's High: My Life in Motion by Dean Karnazes Marathon Maniacs 50 States Marathon Club Spartan Race Spartan Up Podcasts Can You Endure? Lisa Tamati and Joe de Sena The Spartan Way by Joe de Sena Marathon Training Academy: Website | Podcast | Instagram | Twitter | Facebook      Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/.   Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, Run Longer  Without Burnout & Injuries Have you struggled to fit in training in your busy life? Maybe you don't know where to start, or perhaps you have done a few races but keep having motivation or injury troubles? Do you want to beat last year's time or finish at the front of the pack? Want to run your first 5-km or run a 100-miler? ​​Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle?  Go to www.runninghotcoaching.com for our online run training coaching.   Health Optimisation and Life Coaching If you are struggling with a health issue and need people who look outside the square and are connected to some of the greatest science and health minds in the world, then reach out to us at support@lisatamati.com, we can jump on a call to see if we are a good fit for you. If you have a big challenge ahead, are dealing with adversity or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, contact us at support@lisatamati.com.   Order My Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Still, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books.   Lisa's Anti-Ageing and Longevity Supplements  NMN: Nicotinamide Mononucleotide, an NAD+ precursor Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, is being dramatically decreased over time. What is NMN? 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Manufactured in an ISO9001 certified facility Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health My  ‘Fierce' Sports Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection.   Episode Highlights [05:43] About Marathon Training Academy Inspired by Angie's experiences with marathons, Angie and Trevor started Marathon Training Academy back in 2010. Marathon Training Academy helps people learn how to train for a marathon. They also provide tips, strategies, and principles on how to run marathons well.  To date, the show has over 10.8 million downloads.  [08:15] Angie's Marathoning Career Angie shares that we need to be careful about comparing our accomplishments to others.  At first, she started running to lose weight. After giving birth to her second child, Angie signed up for her first 5k race.  Then, she decided she needed a bigger challenge, so she signed up for her first marathon.  Although the experience itself was miserable, Angie knew that she wanted to experience the feeling of finishing a marathon again.  Her personal experiences paved the way for Marathon Training Academy. She wanted to teach others how to train for a marathon so that they won't get injured.  [14:19] Learning How to Train for a Marathon to Avoid Mistakes Many runners think they don't need coaches, but it's essential to have guidance.   Seek good advice on how to train for a marathon so you can reduce injuries.  Being part of a community can also help you avoid costly mistakes.   [16:14] Marathon Training Academy's Growth They started in 2010, around the second wave of podcasting. Back then, many people were still not aware of what podcasts are.  We're now in the fourth wave of podcasting, where even news agencies and TV shows have podcasts.  Trevor shared that connecting with their audience helped build the community from the start.  So, they would do shout-outs during their episodes. They are also active on social media.   Angie and Trevor also recognise the value of their audience's time. So, they try to keep their episodes short while giving out as much valuable information as possible. [20:31] Angie's Journey Towards 50 Marathons in 50 States Angie first heard about running challenges when she encountered the Marathon Maniacs. You can get into this club if you do two races in two weeks or three in 90 days.  At first, she thought that she wasn't up to the challenge, but she proved herself wrong. We often make excuses about not being able to do something. If you surround yourself with people taking on these big challenges, you push yourself as well.  She then challenged herself to run 50 races in 50 states. This endeavour took 12 years. Trevor shares that Angie ran her 50th marathon the fastest. This achievement only proves that age can't stop you from challenging yourself.   [24:47] We're All Different We're all built differently, so don't feel pressured to do back-to-back marathons. Find what works best for you and your health.  Don't be caught up in the misconception that running marathons can slim you down.  Also, don't compare yourself to others — focus on yourself and your progress.  [29:10] Angie and Trevor's Most Memorable Races Trevor's favourite race was the Jungfrau Marathon in Switzerland because of the views. He talks more about the experience in the full episode. Meanwhile, Angie loves the Loch Ness Marathon in Scotland. She also enjoys several other races in the US.  Trevor shares that his toughest race was a 50k race in Montana. He admits that he wasn't able to train for it.  On the other hand, Angie's toughest race is the Leadville Trail Marathon. Located in Colorado, this race starts at 10,000 feet and continues to go up.  [34:23] Lessons Learned from Running Marathons Marathons can teach you a lot about life. As people, we're continuously changing and evolving.  Running accomplishments are good. However, you need to take care of your overall health as you train for a marathon.  We also have to learn how to appreciate the present and the challenges that come with it. Doing hard things prepares you for the struggles ahead. Marathoning teaches you to have a singular focus to reach your goals. [38:50] How Running Marathons Builds Resilience When you do hard things, it becomes easier to push through the obstacles in life. This idea is called obstacle immunity. It's important to acknowledge difficult situations, but don't let that stop you. Instead, use these emotions to fuel you.  Once you overcome a challenge, your horizon expands. You see the other battles you can overcome.  [43:59] How Angie and Trevor Balances Life Angie shares that being self-employed helps them find the time to run and train for a marathon.  They also try to include their children in the marathoning journey.    7 Powerful Quotes from This Episode ‘Running is putting one step in front of the other and then being open to learning.' ‘I think doing things in community makes it so much richer.' ‘A lot of times we make excuses why we can't do something and sometimes, it seems very valid at the moment. But it's all a matter of priorities.' ‘For most of us, it is about you versus you. I think that's the beautiful thing about this sport. That we can all do this together but it's actually each of our journeys.' ‘It is important to have goals and everything, but I think it's also important to just look at your overall health.' ‘If I can't be happy now, I'm not going to be happy in the future. If I accomplish these goals, there's always going to be something else to chase.' ‘Having done hard things in the past prepares you for those challenges that you never wanted to take on in the first place.'   About Angie and Trevor Angie and Trevor Spencer started the Marathon Training Academy Podcast in 2010 to empower and inspire people to achieve better health with marathons. The show shares simple and actionable tips on how to train for a marathon.  Angie delved into the world of marathons after having her second child. However, she was plagued by training injuries. So, she was determined to find a better way to train for a marathon. Thus, the Marathon Training Academy was born.  She has since run 66 marathons with a PR of 3:19:55. She is also a Registered Nurse and a USATF Level 1 and RRCA Level 2 certified running coach. Meanwhile, Trevor is the manager and producer of the Marathon Training Academy. He has completed 17 marathons, one 50k, 21 half-marathons, and a Spartan Trifecta. Want to learn more about Marathon Training Academy? Check out their website and listen to their episodes on Apple Podcasts, Stitcher, and Spotify.  You can also reach out to them on Twitter, Instagram, and Facebook.            Enjoyed This Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends to inspire them to seek challenges and teach them why it's crucial to train for a marathon well. Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You can also tune in on Apple Podcasts. To pushing the limits, Lisa   Transcript Of The Podcast  Welcome to Pushing the Limits, the show that helps you reach your full potential with your host Lisa Tamati, brought to you by lisatamati.com.  Lisa Tamati: Hi, everyone. Lisa Tamati here at Pushing the Limits. Welcome back to the show. Today, I have Trevor and Angie from the Marathon Training Academy in the United States, really well-known podcasters and run coaches. So our equivalent, over in the States. But these guys have been going for a long time and doing fantastic things. I heard their podcast when I was looking for information on my friend Dean Karnazes's latest book and listened to the podcast. I thought these guys are really rock stars, so I reached out to them. I have them on the show today so really exciting. They're in Montana in the United States, and they've got some great ideas and great information for you. This is one for the runners out there, and we get into all sorts of topics as well. Really, really exciting.  Before we head on over to the show, just want to let about our epigenetics program. We'd love you to come and do our flagship program about epigenetics to help you understand your genetics and how to optimise. This is really the future of personalised health is understanding what your genes are doing. All your health professionals should be personalising everything to your own genetics, and this information is pretty damn valuable. If you want to have a user manual for your own body, understand what food you should have, what types of exercise you'll benefit mostly from, your mood and behaviour, your hormones, what predispositions you have, all this fantastic information that you'll get about yourself when you go through this program.  Then, we can help you actually put it into place so how do you actually... Because it's great to get information and reports. A lot of the DNA reports that you get, you basically get 'Oh, that's nice' and it's a report and you stick it in your top drawer because you don't know what to do with it. But that's what we help you with. It's really powerful information that can really change your life. It certainly changed mine and changed my approach to different areas in what I do, what I eat, what times I do things, the way I set up my entire day, all of these things are affected. Head on over to lisatamati.com, hit the 'Work with Us' button and you'll see our Peak Epigenetics Program there.  We've also got BOOSTCAMP coming up on the first of September. You'll be listening to this after that so this round will have already started but we will be running this eight-week live webinar program again. We'd love you to come and check it out if you want to upgrade your life in all areas, understand how your biology works, understand everything that can help you achieve high performance, help you with health journeys, a really intimate small group of people who are wanting to upgrade their lives. Make sure you check that out. You can go to peakwellness.co.nz. I'll say that again, peakwellness.co.nz/boostcamp.  Lastly, before we head to the show, don't forget our NMN supplements. nmnbio.nz is where you'll find out all the information about this longevity and anti-aging supplement by Dr Elena Seranova, a molecular biologist, really powerful supplement that has been doing some amazing things for me, and my life, and my family's health, and turning back the clock, basically. It's up-regulating your sirtuin genes, which are your longevity genes, helping with the NAD levels in your cells which are... Every single cell needs NAD and these deplete as we get older, so check out the science behind it, check out the information. There's two podcast episodes that I've done with Dr Elena also on Pushing the Limits, go and check those out if you want to do a deep dive into it. Head on over to nmnbio.nz.  Right. Now, just before we head over to the show, I want you also to maybe follow us on Twitter, on Instagram, on YouTube. Especially our YouTube channel. If you can go and subscribe to our YouTube channel, that really supports the show. All of the shows are actually put up on YouTube. Just, if you search for Lisa Tamati when you go to YouTube, you'll come up with my channel and make sure you subscribe. There's a ton of videos on there. We've got about 600, I think, including all my documentaries as well. Make sure you check that out and we'll head on over to the show with Trevor and Angie.  Hi, everyone and welcome back to Pushing the Limits. This week, I have Trevor and Angie from the Marathon Training Academy. It's super exciting to have you guys. Welcome to the show.  Angie: Thanks so much, Lisa. It's great to be here.  Trevor: Yeah, we're excited about this.  Lisa: Yeah, well, I found you actually through a mutual friend, Dean Karnazes, who I know you've had on the show a couple of times. Dean's been a huge influence in my life as you can possibly imagine. I owe him so much both as a role model and as a friend. He's done lots of things for us. He's a wonderful guy, so shout out to Dean, who I think has just got out of lockdown in Australia. He was intending to run around Australia and that's been curtailed because of the bloody COVID thing. Yeah, shout out to Dean. Thanks for introducing us. I just loved your show so I thought, 'Well, I got to have you guys on.'  You guys are running coaches, and you have three kids. Let's start there. Tell us a little bit about your training academy, and what you do, and your podcast, and all that sort of good stuff. Trevor: Yeah, awesome. Well, thanks for the opportunity to be on the podcast here. I'll introduce myself. This is Trevor. I am America's most okay-est runner.  Angie: I thought you were gonna say laziest.  Trevor: Laziest? No.  Lisa: That's me.  Trevor: Angie is my better half. She's actually the running coach. I'm more like the business guy behind the scenes. We started in 2010. We launched the Marathon Training Academy podcast because we figured, 'Hey, maybe Angie had some knowledge and experience running a couple marathons, maybe people would benefit from learning how to do it.' We launched it and have been pretty much releasing content consistently for the last 11 years. It is not easy, as you know.  Lisa: No it is not. It is so, so impressive to keep going for that long. We've been going five and a half years, and I thought I was ancient and the podcast basically. So amazing. You've got a huge following and a huge... You're telling me some of your download stats and I'm like, 'I'm embarrassed.' You guys are rock stars.  Trevor: I guess we've been fortunate in the beginning when we've launched. I don't think there was a lot of competition for what we were talking about there. At least in the US, on iTunes, there was podcasts where people would carry a recorder out when they ran and they would just dictate breathing really heavy into the mic and stuff. There wasn't a whole lot of prescriptive training advice, which is what we tried to do. When we tell stories and we do race recaps and take people with us as we go racing around the country. But we try to be prescriptive: sharing lots of tips and strategies and principles.  Angie's also a registered nurse as well as being a running coach, so that appealed to people. It just took off in the beginning. We got lucky. I guess it was dumb luck. I don't know, but we started connecting with people right away. Folks would email us from all over the world. We just had a great audience ever since. I just checked the numbers today. Our show's been downloaded 10.8 million times since we started.  Lisa: That is insane. I got a long way to go to catch up to you guys. You guys are rock stars. Angie, you are a legend in the running space. You've already done 50 marathons in 50 states, for one thing. Tell us a bit about your career.  Angie: Well, I definitely don't feel like a legend. I guess that's when you are the person who is doing it all you always kind of feel like, 'Wow.' I kind of feel there's still so much that could be accomplished. There's always that comparison trap we can fit ourselves into. There's always someone who can run faster unless you're Eliud Kipchoge. There's always somebody who's done more crazy challenges. I think that's a dangerous field to start comparing yourself to other people, but I will say that I started running off and on when I was a teenager. I didn't have a great motivation. It was more about trying to lose weight. When I didn't see instant results, then I would kind of give it up and be like, 'Oh, this isn't working.'  But I do feel I really finally became a runner in my late 20s. We'd moved across the country. It was a move that I really didn't want to make. It was for work, and I had two little kids at home. I just felt I was stuck, and I needed a new challenge. Kind of on a whim, I signed up for a 5k race and they say the 5k is the gateway drug to long-distance running. In my case, it was. It was a completely miserable race. It was hot and humid and I'm not a good hot weather runner, but I felt there was a spark inside me. This is something that really fired me up. It wasn't about beating other people. In fact, I had a very, very average time but I just kind of felt like, 'Wow, I bet you I can get better at this.'  I'd never considered myself an athlete before. I never played any sports, so running was something, it was just kind of me against me. I decided I need a bigger challenge, so I signed up for my first marathon. At the time, I didn't have any friends who are runners. They probably would have advised me against it, actually. I don't know anyone who had ever done a marathon before. In fact, at the time, we were so poor that I could either afford the race registration or a new pair of shoes. My mom actually paid for my race registration, so I consider her my first official sponsor.  I'm training for this marathon on my own. Long story short, I do everything wrong. I just run. I don't do any kind of recovery or cross-training or strength training. I'm getting injured, dealing with back pain, and IT band pain, and all the things, but I was stubborn enough that I kept going and was able to finish the marathon. Although it felt completely gruelling at times, just when I crossed the finish line, it really... I was like, 'Wow, I know I'm going to do this again.' That kind of just started my journey. I actually, after that first marathon, had to take three months off of running because my IT band was so bad. Had knee pain. The whole nine yards.  That's when I started doing yoga and kind of discovered like, 'Wow, I can really start to learn more about my body, not ignore these signals that it's sending me.' There are some areas that need to be strengthened and I think that kind of sowed the seeds for what became Marathon Training Academy. Because I wanted to help people have a better experience than I did the first time: have the knowledge, have the information to not get injured and not have to do things the hard way.  I went on to run my second marathon training much smarter and was able to break four hours for the first time, which was a huge goal of mine. I think that's kind of when Trevor mentioned wanting to start a podcast about marathon training. I was like, 'I don't feel like I know enough. Who's going to listen to us? We're just sitting in our living room recording this thing.' I had very low aspirations for where it was going to go, but he had the vision. We stuck with it and just have had a very wonderful, gracious audience. We've just been able to meet so many amazing people throughout the years. I think that's been the most rewarding part of it.  Lisa: That's amazing. Trevor, your wife's bit of a superstar, from what it sounds, but she's very humble.  Trevor: She's amazing. She puts me to shame. She does everything that you're supposed to do, that your coach tells you, that you see on your training plan, doesn't miss a day, doesn't miss a workout. I do 25% of my training plan. Lisa: That's brilliant though. But I love the fact that you... Like me, when I started running, I had no idea what the hell I was doing. I just put one foot in front of the other. I was hopeless, and I was slow. I'm still slow 25 years later. Genetically speaking, not the most gifted person in the world but very, very stubborn. That's all you need with running. I love that you are all about the everyday runner. We have a running coaching arm of our company as well,  and we are very much into that holistic approach to running too, with the strengths, and the immobility, and the mindset, and the nutrition, and all of that sort of stuff.  I had no idea about that back in the day and I just bumbled along, running long because that's what you did, isn't it? If you're going to run long, you run long. What the hell is strength training? What do I need that for? I think we know we've both bumbled into the space and this is the key thing, I think, from your story. That when you just keep going, and keep going, and keep going, you suddenly find yourself looking back on, 'Holy heck, I've done a lot. I've done some pretty amazing things.'  It's just like running is putting one step in front of the other and then being open to learning, getting good coaching so that you... because I like what you said, Angie, about making mistakes and then not wanting other people to make them. That is just the motivation for what we do too because I reinvented the entire wheel, and you don't need to. Do you find a lot of runners come and they don't think they need a coach for starters? Most people only come to you when they're injured. Is that happens to you guys as well?  Angie: Yeah, I think often, there is part of human nature, and I think certain personality types who are more driven to like, 'I'm going to do this myself and I'm stubborn. I'm going to see this through.' Yeah, maybe they've tried a few times to hit a specific time goal that they have, and they realise, 'Wow, it's not going in the direction that I thought it should be going or the injury issues.'  I think people's knowledge and information, it's better now. There's so much more out there that a lot of people who are probably smarter than I was are like, 'Hey, I can probably cut out the injury part, and I can get good advice and good help in the beginning and make this so much a better journey.' I think also for me, I went alone for the first few years. Just being part of the community makes it so much more special, and I think the running community is just amazing. You meet the best people and have conversations with people like you. I think doing things in community makes it so much richer.  Lisa: Oh, man. I could learn so much from you guys. I think you've got a really good approach to it. Trevor, looking back into podcast space, because you say you're the businessman behind the amazing lady, got any tips for a podcaster? Because obviously you guys are doing something right. You started off in this space like... You've grown this massively. I know what goes into it. When you come to it a bit later, it's been a bit harder, for sure. What have you learned on that journey from a community-building point of view? Because I feel we've still got work to do in that space, and I'm always keen to learn from people who are so successful.  Trevor: Well, one thing, when Angie was talking and she was telling the story of when I pitched the podcast idea to her, one thing she didn't tell you was her first response was, because this was 2010, actually '09 when I pitched the idea. Her first response was, 'What's a podcast?'  Angie: Totally ignorant.  Lisa: Yeah, we still get people not knowing what the hell a podcast is.  Trevor: Yeah, so I think getting in early, obviously, was a big help to us. Kind of to be on the front end of a trend. We actually started in what was called the second wave of podcasting. Podcasting got going in earnest around '06, so they say that was the first wave. And then around 2010 was the second wave. There's a lot more shows starting and now, we might be in the fourth wave of podcasting now where almost every major company has a podcast, every news agency and every late-night TV show host.  It's definitely a more crowded space. But on the other hand, there are still people, like you said, who'd never heard of a podcast. More and more people are coming to the medium, downloading shows. Podcasts is becoming more mainstream. I know here, at least in the US, it's not unusual to hear people on TV talking about podcasts, just in anywhere you look, you can see subscribe to my podcast. It's cool to see the cultural awareness rise since we've started.  But I think in terms of tips on growing the show and community, one thing that helped us in the beginning, and still helps us, is hearing from listeners, featuring their stories. At the top of our show, every episode, we do shout outs where kind of like a virtual high five. People are, like all of us, people like to hear their name in a podcast. It just makes them feel... Yeah, lights them up. It puts a smile on their face, and we try to do that a lot where we engage the audience that way. Then, the off-podcast stuff too is also important like our social media stuff and all that. Yeah, building community. Angie: We also kind of try to keep in top of mind like, 'What's in it for the listener?' Because at the end of the day, people only have so much brain space and time. They're going to keep listening to shows that they feel you're giving them good value and that they connect to you in some way. I think just keeping that listener focus and stuff. No one wants to hear about a dissertation of what we've been doing for the last week in-depth. They want to get to know us a little bit, but they also want to know that we care about their needs and everything and what's top of mind. I think that's been helpful as well.  Trevor: Yeah, I edit our show judiciously. Oh, yeah. I spend way too much time. I'm just a perfectionist with it. I haven't been able to outsource that yet, so I edit our show and I'm like, I don't know what the word is, I'm just a stickler when it comes to audio quality. Also like Angie said, I know people's time is important, so if we go down a certain path in the conversation that I think is not pertinent enough, I'll just cut it. I'll take that one-hour episode then maybe sometimes cut it down to 40 minutes.  Angie: He has to edit out all my ‘likes' and ‘you knows', all my verbal clutter. It takes about half of the content away. Lisa: It's so much work. It's just so much work but I love that you do that, and you're a perfectionist. I'm technically completely disabled. I have a team of people behind me doing a lot of stuff, but we can still improve and get better. I love the meandering type of conversations that we have. Let's go and talk a little bit about... For start, Angie, I do have to ask you about your 50 marathons in 50 states, like our friend Dean. How did that come about and when did this become a challenge?  Angie: Well, sometimes things just kind of sneak up on you. I think it was my fourth marathon and it was before the race. I was sitting around talking to a couple ladies and they had these shirts on that said: 'Marathon Maniacs.' I was like, 'What do those shirts mean? What's a marathon maniac?' They're like, 'Oh, it's a club where you have to run a certain number of marathons to be able to get in.' I was like, 'Oh, how many?' They said, 'Well, you have to do two in two weeks or three in ninety days.' I was like, 'What?' That's crazy. That's a maniac.' I was like, 'I could never do that.' I said that I could never do that, and they're like, 'Oh, you could if you really wanted to.'  That just kind of stuck with me. I was like, a lot of times we make excuses why we can't do something, and sometimes, it seems very valid at the moment. But it's all a matter of priorities. That stuck with me. I'm like, 'Could I do that?' Later that fall, I did end up doing three marathons in that 90-day space, and I became a marathon maniac. When you surround yourself with people who are doing all these big challenges... I would joke that I was like a baby maniac because there was people who had done three, four, five hundred marathons in the club that you would see at these races.  Then, of course, I heard about the 50 state club. People who run a marathon in each of the 50 states. I thought, 'Wow, that would be cool. I already have a few states under my belt. Why not?' It doesn't have to be anything like Dean Karnazes doing it in 50 days. No one cares how long it takes and everything. Both Trevor and I love to travel. It seemed like a really great way to be able to explore our very diverse country and see all these amazing places, get to run. It just kind of started that way, and it took me 12 years to finish all 50 states. But it's about the journey and not the destination.  Lisa: Absolutely and that is a really... It rolls off the tongue really beautifully. Yeah. I've done a marathon in every state, 50 states.  Trevor: Here's what's cool, Lisa. I don't know if Angie is going to tell you this but she actually ran her last marathon fastest. That was her fastest marathon. That's what's so cool about our sport: that even though you get older, you can still improve in so many ways. Her very 50th state was in Hawaii. She ran 319, qualified for Boston by 20 minutes and that was at age 41. She was 10 years older but ran an hour faster than when she started.  Lisa: I love it. Go, the oldie. I'm way older than you, so I can say that. I totally agree. Endurance is one of those things. I read a statistic once said a 19-year-old and a 64-year-old are on the same level of endurance or something. You peak around 48 as far as endurance goes and I'm like, 'Yeah, amen to that.' I have similar stories. I did my best performances in my 42, 43, around that age were my peak performances. I'm way after that now, so things have slid off a little bit. Of course, it's what's going on in your life. I've had a few other dramas in my life. There's reasons for things slipping off, but I love that. 319 is an incredible time. That's just amazing. Angie: I still can't believe I did that. Was that me? I don't know. It was just one of those days where everything comes together, and you can never predict that.  Trevor: In Hawaii to boot.  Lisa: Yeah, isn't it really hot in Hawaii? Isn't that really difficult to do?  Angie: It was January so it was cooler, but it was hot compared to what I was used to. Lisa: Amazing. Trevor, how many did you do of those states? You did a few of them?  Trevor: I have. I think I'm up to 17 marathons. I'm actually doing my 18th in about 10 days from now.  Angie: But he's done a lot of half marathons. A lot of the time where I'd be doing a marathon, he would do the half marathon so he's probably run in most of those states as well.  Lisa: I study genetics, right? We have a epigenetics and functional genomics arm to our business. Everybody is genetically different. When people listen to you and go, 'My god. She's amazing. She's run 50 marathons in 50 states.' I want people to not take away from that that they should be doing back-to-back marathons because even though yeah, that's really cool to have these challenges, we're not all genetically set up for that. We need to respect that sometimes. It's been fascinating, this journey of learning about genetics.  When I did my genetics, it came back... Actually, I'm really not suited to the super long-distance running. I was like, 'What? Is that why I've got all these health problems?' Actually, my body is more set up... That doesn't mean I can't ever do an ultramarathon again, but it does mean if that if I want to have longevity and health for a long time which I do now, because I'm 50 so I want to make sure that I stay on top of things, then I shouldn't be doing back to back ultras.  That my body is much more suited to doing shorter and high-intensity sort of workouts and lots of yoga and Pilates and things as well.  I just want people to take away from there, everybody is different. For some people like my husband, he can run super super long, and it's genetically good for him to do that. For me, not so much. One of the other things that I've found within our running coaching, and we get a lot of ladies, we're probably about 70% ladies in our run coaching community. A lot of them are in their 30s, 40s, 50s. It's not the best weight loss thing, is it?  Angie: I could gain weight while running marathons and even watching what I'm eating so yeah, it is definitely. It's tricky.  Lisa: Yeah, it's not. For people to understand, if you're wanting to do a weight loss program, that would be a completely different program that I'd set you than if you're wanting to do marathons for the challenge of doing a marathon. Because there is this misconception that yeah, 'I run a marathon and I get really thin and slim.' No. I got fatter doing marathons. When I ran through New Zealand, I put on weight, and I was running 70-odd kilometres a day. Then, I put on my... I'm like, 'The hell is this about?' Everybody is different. Respect your genes. Respect your body. And as Angie said at the beginning of this podcast, compare yourself only to yourself. Unless you're in the Olympics, then, you probably compare yourself to the others. But for most of us, it is about you versus you. I think that's the beautiful thing about this sport. That we can all do this together but it's actually each of our journeys.  Just interrupting the program briefly to let you know that we have a new patron program for the podcast. Now, if you enjoy Pushing the Limits, if you get great value out of it, we would love you to come and join our patron membership program. We've been doing this now for five and a half years and we need your help to keep it on air. It's been a public service free for everybody, and we want to keep it that way. But to do that we need like-minded souls who are on this mission with us to help us out. So if you're interested in becoming a patron for Pushing the Limits podcast, then check out everything on patron.lisatamati.com. That's patron.lisatamati.com. We have two patron levels to choose from. You can do it for as little as 7 dollars a month, New Zealand, or 15 dollars a month if you really want to support us. We are grateful if you do. There are so many membership benefits you're going to get if you join us: everything from workbooks for all the podcasts, the strength guide for runners, the power to vote on future episodes, webinars that we're going to be holding, all of my documentaries, and much, much more. So check out all the details: patron.lisatamati.com. And thanks very much for joining us.  Lisa: Trevor, what was your favourite race that you've done?  Trevor: Oh, thanks for asking. There's this marathon I love to talk about. You've probably heard of it. It's the Jungfrau Marathon in Switzerland. That's such a beautiful place. It's almost unreal. Otherworldly how beautiful it is.  Angie: Probably like New Zealand actually. Really beautiful.  Trevor: I've heard it's nice there too. Well, I haven't been in New Zealand yet, unfortunately. As of right now, Switzerland is my favourite place that I've run. They say that when, for those Lord of the Rings nerds who might be listening, when Tolkien, after World War I, was marching through the Lauterbrunnen Valley in Lauterbrunnen, Switzerland. He sees this amazing place and that was the inspiration for Rivendale in the book, in the movies.  Lisa: They did it there first. Trevor: Yep, exactly. Lisa: Then, we came to New Zealand to film it ‘cause it was even better.  Trevor: What's cool about that marathon is it's just pretty much all up this mountain until you get to this 7,000 feet elevation. It's pretty much a lot of power hiking. Yeah, exactly. It's pretty much a thousand... It's pretty much a lot of power hiking after the second half, which is fine because I felt like I was still making progress. But people were throwing up on the side of the trail, and I was fine because I was just I'm just power hiking. I was kind of used to it. That's been my favourite marathon thus far. Plus I had the Alps horns, Swiss Alps horns and stuff. Very transcendent.  Lisa: It was so special. I lived in Austria for 13 years and would go over to Switzerland regularly. Austria and Switzerland are very similar. And just absolutely beautiful. I really miss the beauty of the place, and the culture, and the traditions, and the cool boating. All of those sorts of things. Yeah, it's pretty special. What about you Angie? What's your favourite race?  Angie: I don't know. It's hard to hard to pick one. I would say my favourite international race was the Loch Ness marathon in Scotland. Just going around Loch Ness the lake and just incredibly beautiful. Just the chance to be able to be there and be in the country and see so many amazing things. But I don't know. There's a lot of races that I love here in the US as well. Boston is a very iconic special race. The Marine Corps marathon is really moving. Yeah, Washington, DC. Then, my home state is Montana. I've gotten to do a couple marathons there. Of course, I'm a little biased, but I love the mountains there. Lisa: Absolutely. For both of you, what was your toughest race? Have you ever not made the finish line?  Trevor: Thankfully, no.  Angie: Actually that one race that they closed the finish line. Trevor: Oh, yeah. I remember the marathon in... That was an Austria fact in 2019. They had to shut the course down because of the weather. I think that for me, the toughest race was 50k in Montana. I was probably undertrained because I'm so lazy, and I ended up taking lots of breaks. Angie: Like laying on the ground. Trevor: But I finished before the cut off and I wasn't dead last. Lisa: You take whatever you can get when you go to the bottom of the barrel. That's not much... If you get across the finish line... Trevor: Exactly. It was on the Continental Divide Trail so there's a lot of elevation. How about you, Angie? Angie: There have been a lot of marathons where I finished feeling, or even ultras, that was dragging a body part behind me but I was too stubborn to quit kind of thing. But I think, probably the most difficult one was the Leadville Trail Marathon in Leadville, Colorado because it starts at 10,000 feet and it just goes up from there. There was a section, a one-mile section to get up to Hope Pass, which was the highest point, and it took me 30 minutes to go a mile. I would just walk a few feet, just breathe, gasp for air, pretend like you're taking a picture because you're embarrassed at your pace. That was very challenging because I was not... We were living in sea level basically. To go and do that not being acclimated, it was challenging. Then, to look to the side of the trail and like, 'If I make a misstep, I'm going to fall off this mountain and die.' One of those where I finished and I was just like, 'So thankful to be alive.'  Lisa: Sounds pretty damn scary. What do you think are the biggest learnings from all of these races in this journey that you've been on for however long you've been running for? What what are some of the biggest takeaways? Do you think this crosses over into daily life, and to your businesses, and to the work you do, and stuff like that, and challenges in your home life, and stuff?  Angie: Yeah, I would say the marathon and any long-distance running is a great metaphor for life because you have to look at the long picture. Like you were saying earlier, we're always changing and evolving as people, and we have to keep that in mind. I've kind of through the years, through some trial and error, my goal is to be a strong healthy runner for life. Being healthy through that lifespan is way more important than any one race for me. I think that it's very important like we see people who are taking on these challenges.  It is important to have goals and everything but I think it's also important to just look at your overall health. Is your sleep, is your nutrition, is your overall strength, are your relationships good? How is your mental, and your emotional, your spiritual life? All those things go hand in hand. I think that at some point, running accomplishments are only going to be so satisfying if those other things aren't in place. That's been a big thing for me. I tend to be really goal-oriented person. Always looking to the future like, 'When this happens, I'm going to be happy and be satisfied.'  I finally came to the realisation that if I can't be happy right now, in the imperfect, the way life is if I can't be happy now, that I'm not going to be happy in the future. If I accomplish these goals, there's always going to be something else to chase. That's been something that I've been thinking about lately of just how to really appreciate the present. I think that really goes into running or whatever people's goals are because there's going to be a lot of the present that is challenging and that we don't want to go through. I think it's important to do hard things, take on hard challenges. But there's going to be a lot of hard things that find us that we don't want to have to deal with, that we're going to be forced to wrestle with. I think that having that long-term goal and having done hard things in the past prepares you for those challenges that you never wanted to take on in the first place.  Lisa: Yeah, when you've been struggling, going back to the genetics, you probably got a dopamine thing where you have to be chasing dopamine all the time. I know I've got that gene called the DRD2 gene where I don't have a heck of a lot of receptors for dopamine, so I'm always chasing a mission. Just coming to understand that about yourself, it's like, 'Aha. That's why I tend to...' Like my brother said to me once, 'Why are you always on a mission? Why can't you just sit on a beach and enjoy the day?' ‘It's like asking a table not to be flat. That's who I am. I get up and I'm missioning all day, every day.' And I'm like you, Angie. I'm trying to change the talk in my head to being present.  Sometimes, when you are going through challenges and life keeps chucking them at us at the moment, you don't want to be in the now. One of the big things that I really miss because I'm not doing ultras anymore, is having that single focus, one goal. Life was purely about being a selfish athlete who's just got on a mission. I don't have the luxury of that now with things in life. I miss it. I miss it terribly. That simplicity of life where you've got just one big huge goal and you're doing your work and stuff. But this is the one thing, and then when you're actually in the race, that's what I found beautiful about racing, you're not thinking about the mortgage and the what's going on in the family or anything else because you're just like, [imitates heavy breathing], ‘Got to get up this hill.'  Angie: To the next aid station.  Lisa: Right in the moment. For so much of my life, I know that I'm in the future or the past and that's really learning to be in the now without having that single singular focus. Really wise words, Angie, I think. Trevor, what would you say that running has bought to your mental resilience and toughness and ability to cope with things?  Trevor: Well, I know running marathons makes a lot of other stuff seem easier. Yeah. I remember how tough my first half marathon was, and I thought I was going to die because I was pretty much a non-runner previous to meeting Angie. After I did my first full marathon, then a half seemed a walk in the park. It seemed so easy even though they're still challenging, especially if you're trying to race a half marathon. We've had Joe de Sena on our podcast a couple of times. He's the founder of the Spartan Race. Lisa: Yeah, I've been on his show. Awesome.  Trevor: Oh, Cool. Yeah. He's a scary guy. I always remember something he talks about in his book, Spartan Up and that's obstacle immunity. When you make yourself do hard things, you become immune to obstacles in life. You can just push through them, hurdle over them. But it's when you're playing it safe, when you're afraid to get out of your comfort zone, sign up for that challenge, that marathon, or whatever your challenges is, it's this when you get more timid and hard things seem harder than they really are. It's all in our heads.  Lisa: Ah, that's gold. Obstacle immunity. That's going on my Instagram today. Thanks, Joe. Because it is. When somebody or when someone tells you can't do something, that's just for me like, 'Oh, we'll see. I don't agree with you. We'll find out.' That's really served me well. The more that you realise when people tell you can't do something, and then you go and do it, that's just other people's limiting beliefs. This is an all areas, certainly in the medical space and with story with my mum that my listeners know about. If I'd listened to everybody telling me I can't do something, we would never be where we are now. I think you have this mentality. You have, 'Oh, obstacle? How do I get around that? What else can I do?' Rather than, 'Oh, obstacle. I have to stop and sit down and cry and that's it.' I think that mentality is brilliant. Obstacle immunity. Hear, hear. I love it. Angie: It doesn't mean that you don't feel those hard feelings as you get over the obstacle. I think it's important to acknowledge that it's hard and take time to feel that frustration or that sadness or that disappointment. But I think also acknowledging those emotions helps you get over the obstacle too because you're not fighting your emotions then. You're using those and using that to fuel your fire or to just do what needs to be done. Lisa: What I think is beautiful too is when you look back and you've overcome challenges that makes you stronger for the next challenge. You lift your horizon up every time. You get to the end of your first half marathon. For five minutes, you go, 'I never ever want to do that again because that hurts so much.' Then the next day, you're on the internet, 'What is the next one? Where's the next challenge?' You can see runners do this over and over again. I just laugh now when they say 'I'm never doing that again.' Because it's usually until the pain wears off and they're off on the next mission.  It is like lifting your horizon every time. It's not something that stays out there permanently either, by the way. You build yourself up to marathon, ultramarathon, whatever your goal is. Then if you don't do it for a while, I can tell you as someone who's not doing ultras now, your world starts to shrink back in as to what you are capable of doing. For me, I'm thinking, 'Can I do a half marathon?' That's what I would like at the moment with a load that I've got on, which is a lot, 'Can I get back to that stage?' My focus has been on CrossFit and other things.  My body's changed considerably, for the better I'd say, but when it comes to going back long, whoa. I've got to push that horizon back out again. It doesn't stay permanent. In other words, it's a constant work battle really to keep it. When you're getting older, you've also got that aspect coming into it too, trying to keep things at bay. I had Dean on the podcast last week and we were talking about that because we're both somewhat north of 40. It's like, 'Yeah, things aren't quite working like they used to do. I'm like, 'Yeah, I'm working on that. I've got all these things for you, Dean.' 'Some great longevity stuff. Come try this and do that.'  That's sort of an interesting path to go down to because you start to think, 'Well, I can keep my fitness to the best that I can by keeping up with the current research, and the knowledge, and stuff, and doing the best things, and prioritising things like sleep.' You can have a massive impact on your body, and it's not just about the training I think is what I'm... Yeah. Guys, you've also got three kids. Three kids, busy life, running marathons. Most people can't, I can't do that. How do you find the time?  Angie: Well, we are very fortunate that now we are self-employed. We kind of can design our own schedules, and I think that's a big advantage to the training because some days, it happens at a certain time. Some days, it has to be pushed around a bit because of appointments, kids, things that we've got going on and everything. We've also tried to include our kids in the journey. Especially when they were young, they would travel with us a lot and they got to go to so many of the states that we travelled to. We tried to expand their horizons as well.  Now that they're older and everything, sometimes, he travels, he's going to Italy next week. I'll stay home with the kids, and then I'll go somewhere in September. It's just about making it work and making sure the family is supportive. It's not like your family has to be your biggest fans because there's only a certain level that your family is going to get it. Like our kids could pretty much care less that we do marathons. They're like, 'So what?'  Lisa: Yeah, yeah. Yeah, I know. I hear you.  Angie: 'What are you making for dinner, Mom? I don't care that you just ran a race.' You know that kind of thing? Lisa: They're very good at bringing you back down to earth, family. I've got brothers and yeah. 'You ran across the Sahara? Oh, yeah. Whatever.' 'Oh, you wrote a book? Oh, that's cool. I'll never read it.'  Angie: 'What's it about?' 'Okay.'  Trevor: That's cruel.  Lisa: But that's family, that keeps you keeps you grounded. 'Oh, would've been nice to get a pat on the back.' They're not like that at all. Very supportive actually, but when we were younger, that was definitely the case. Probably vice versa because my brother does surfing and I'm always like, 'Oh, yeah, are you just riding 20-foot waves? That's cool.' Now, I'm sort of like, 'Oh, Wow. That's pretty awesome. Go guys.'  You guys have been epic today. Thank you so much for being on the show. I really appreciate it. I thank your podcast. And tell everybody where they can find you: Where's the best home to find you on the internet and Instagram and all those sort of good places and how to connect? Trevor: No problem. Yeah, thank you so much for the opportunity to be on the podcast, and if anybody wants to find this, you can just go to marathontrainingacademy.com. If you are looking for our podcast, if you just type in marathon training, we usually just come up as the first result, but it's called The Marathon Training Academy podcast. We're on Instagram, @MarathonAcademy.  Lisa: Wonderful. I will put all those in the show notes. Thank you very much guys for your time today. It's been absolutely wonderful chatting with you.  Angie: Thank you so much. Trevor: Likewise. Thank you.  That's it this week for Pushing the Limits. Be sure to rate, review, and share with your friends, and head over and visit Lisa and her team at lisatamati.com   

Už 155 let uplyne od narození zakladatele moderní Číny a jejího prvního prezidenta Sunjatsena. Zemřel dřív, než mohl své ideály uvést do života. Nad jeho významem se v pořadu Portréty zamyslí historik Jan Adamec.

Alan Cash got curious about why our energy pathways fail us. Armed with an MS in physics, he's found himself innovating commercial production methods for oxaloacetate, a metabolite in the citric acid cycle that sits squarely within our mitochondria and are fundamental in producing the ATP that fuel every energy-requiring process in the body. In this episode, we review the nitty gritty details of energy production from the perspective of how oxaloacetate (brand names Benagene and Jubilance) can impact us from the systemic perspective. We don't typically discuss one commercial product on our show, but we have many patients using oxaloacetate and wanted to give a much more complete picture than we can in a clinic visit. Taking oxaloacetate has been shown to decrease NF-kB activation, reduce fasting glucose by ~25% (research from the late 1960's), increase NAD to NADH ratios, increase AMPK, decrease emotional symptoms of PMS (as the product Jubilance) and favorably shift cellular redox. Preliminary data from Mr Cash's current research is showing reduction in fatigue for CFS/ME patients. Remarkably, oral oxaloacetate seems to be able to cross the blood brain barrier (it's a very small molecule!) and can decrease brain glutamate levels. Most remarkably, taking exogenous oxaloacetate can mimic caloric restriction and has increased the lifespan of laboratory animals. It's been used in doses ranging from 100 to 6000mg daily (like for glioblastoma) and has been well-tolerated even at high doses. It's important to know that the commercial products Benagene and Jubilance contain the same ingredients: 100mg of oxaloacetate stabilized by 150mg of vitamin C. To answer another common question, there's no mechanism to turn oxaloacetate into the undesirable 'oxalate' compound in the human body. This tiny molecule really can pack a molecular and anti-inflammatory punch- listen in to find out more! Resources: https://benagene.com/ https://jubilance.com/ Oxaloacetate to reduce emotional symptoms in PMS: placebo-controlled, cross-over clinical trial with 48 women (2020): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073356/ Safety and target engagement profile of two oxaloacetate doses (500mg & 1000mg twice daily) in 15 Alzheimer's patients (2021) showed the higher dose increased frontal & frontoparietal brain glucose & glutathione per FDG PET scanning despite no changes in serum levels or cognitive scoring. https://pubmed.ncbi.nlm.nih.gov/32715609/ Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation & stimulates neurogenesis (2014) in mice injected with 1-2g/kg once daily dosing x 1-2 weeks. https://pubmed.ncbi.nlm.nih.gov/25027327/ Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans (roundworms) by 25% median & 13% maximal lifespan through an AMPK/FOXO-dependent pathway (2009). https://onlinelibrary.wiley.com/doi/10.1111/j.1474-9726.2009.00527.x Oxaloacetate: A novel neuroprotective for acute ischemic stroke (2012) via modulation of the glutamate pathway which would also be applicable for other types of brain injury, like TBI (traumatic brain injury). https://pubmed.ncbi.nlm.nih.gov/22085530/ Neuroprotective effect of oxaloacetate in a focal brain ischemic model in the rat (2015) through pathways of glutamate scavenging. https://pubmed.ncbi.nlm.nih.gov/24807461/ Neuroprotective effects of oxaloacetate in closed head injury in rats is mediated by its blood glutatmate scavenging activity (2009). https://pubmed.ncbi.nlm.nih.gov/19543002/ Effect of alpha-ketoglutarate & oxaloacetate on brain mito DNA damage & seizures (2003). https://pubmed.ncbi.nlm.nih.gov/12749815/ Oxaloacetate acid supplementation as a mimic of caloric restriction: https://benthamopen.com/contents/pdf/TOLSJ/TOLSJ-3-22.pdf

In our fast-paced world, everyone feels pressured to be the best and to do their best. It's easy to succumb to worry and anxiety during this time. This week, a superstar athlete encourages us to reframe pressure as an opportunity. You may not be involved in the sports world, but you can still learn from it. For our guest, overcoming high-pressure situations boils down to two things: trusting in the preparation you've done and taking things one step at a time.  Retired All Blacks player Conrad Smith joins us in this episode to talk about his experiences in the sporting world. He gives us a glimpse into his childhood and how he transitioned in and out of professional rugby. It's easy to make sports your whole identity if you're not careful, and Conrad details how athletes can avoid this trap. He also shares how we can equip ourselves to handle high-pressure situations. If you want to hear about Conrad's tales with the All Blacks and know how to be better at dealing with being pressured, this episode is for you.    Here are three reasons why you should listen to the full episode: Gain insights on the dangers of being too immersed in a sports bubble.  Learn how you can deal with feeling pressured. Understand the importance of adaptability in our fast-changing world. Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron!  A new program, BOOSTCAMP, is coming this September at Peak Wellness! All Blacks  International Rugby Players    Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/.   Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, Run Longer  Without Burnout & Injuries Have you struggled to fit in training in your busy life? Maybe you don't know where to start, or perhaps you have done a few races but keep having motivation or injury troubles? Do you want to beat last year's time or finish at the front of the pack? Want to run your first 5-km or run a 100-miler? ​​Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle?  Go to www.runninghotcoaching.com for our online run training coaching.   Health Optimisation and Life Coaching If you are struggling with a health issue and need people who look outside the square and are connected to some of the greatest science and health minds in the world, then reach out to us at support@lisatamati.com, we can jump on a call to see if we are a good fit for you. If you have a big challenge ahead, are dealing with adversity or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, contact us at support@lisatamati.com.   Order My Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Still, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books.   Lisa's Anti-Ageing and Longevity Supplements  NMN: Nicotinamide Mononucleotide, an NAD+ precursor Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, is being dramatically decreased over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. Founded by scientists, NMN Bio offers supplements of the highest purity and rigorously tested by an independent, third party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful third party tested, NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of aging while designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health   My  ‘Fierce' Sports Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection.   Episode Highlights [02:59] Conrad's Childhood Conrad's family used to move around until they settled at New Plymouth when he was six. His family was very close, as his parents always made time for him and his siblings.  They were also supportive of both his academics and sports. Conrad spent most of his childhood playing sports and helping out on their family farm.  [09:03] Conrad as a Young Sportsman  Conrad wasn't initially an overachiever when it comes to sports.  During his time at school, rugby didn't take up a huge portion of his life. Conrad didn't feel pressured to play, unlike most kids involved in sports today.  He's very grateful that he was able to finish his law degree before he started playing professionally.  [11:44] The Dangers of the Sports System Nowadays, there's an obsession with finding talent and training them hard from a young age.  The rationale behind this is to give these kids the best chances of success. However, Conrad is sceptical about this approach. He believes that balancing life and sports is crucial, especially because sports is a short-term career. Many athletes end up going bankrupt or developing depression because they don't have a life outside of playing sports. [16:26] Staying Grounded When you're in a sports bubble, it's easy to lose touch with reality. If you're handling a high-paying sports career, you can forget how real people live. Athletes need to stay grounded and not tie their identity with their sports. This way, they can land on their feet after the bubble bursts.  The challenge is to find other things that you enjoy and avoid the trap of coaching after your playing career ends.  [29:39] On Career Transitions With the rapid changes in the world, we need to adapt to stay relevant.  It takes courage to change your career.  However, you can always find support when you open up to the people around you.   [33:06] Mental Health in Sports  All athletes feel pressured with their sports—what's important is how they deal with it.  When you look at being pressured differently, you can see it as an opportunity.   There's no quick fix for handling high-pressure situations. It's essential to find what works for you. [36:38] How to Deal with Feeling Pressured  Preparation is critical to help overcome feeling pressured.  If you have done the prep work, all that's left for you to do is execute.  Don't get overwhelmed by the bigger picture. Instead, focus on the minute details. You need to be at the top of your game if you're playing in the Rugby World Cup. Listen to the full episode to hear how Conrad overcomes being pressured! [45:21] Conrad's Experiences with the All Blacks Conrad was playing for the Wellingtons when he was picked to play for the All Blacks. His fellow players and coaches told him not to feel pressured and encouraged him to have fun.  For Conrad, being an All Black never lost its glow. He acknowledges what the team means for the country.  He believes that the All Blacks continues to perform well because the players uphold the team's legacy. In particular, their jersey means so much to Conrad. Find out why when you tune in to the full episode!  [52:51] The Future of Rugby Now working as a lawyer in the player association, Conrad speculates that women's rugby will see tremendous growth in the coming years.  The women's rugby players are more motivated by the sport. They want to reach more women and girls through it.  Since this women's rugby is still a relatively small industry, there's not much effort to commercialise yet.  This can be an advantage. It's similar to how small but nimble companies can overtake big industries. [59:56] Conrad's Advice to Parents and Children It is much more harmful to shelter your children from sports. As you get serious about sports, remember to stay grounded and balanced. Connect with the real world as much as you can.  Lastly, be open to opportunities and changes.    7 Powerful Quotes ‘I think it's fine to keep a balance, and to play other sports, and to experience, just live a normal life. I think you can still excel.' ‘You have a crazy number of bankruptcy, crazy number of rates of depression because they haven't learned to live outside of their sport.' ‘You have a lot of retired players that feel like they have to coach because they think it's all they know. The challenge, I suppose is, then of being careful not to fall into that trap.' ‘Whatever you decide that you want to be, you can become.' ‘The bigger the moments and the bigger the pressure, it's the funny thing, it's the more important that you focus on the smaller, minute detail.' ‘If you break it down into one more step, just one more, and then you just keep going and keep going. Then, invariably, that mindset or that thing that's in your head passes and then you're back in the game.' ‘If it's a conversation you're just having in your own mind, you will never get anywhere. You just need to open up about it.'   About Conrad Conrad Smith was a long-time player of New Zealand's All Blacks and helped lead the team to the 2011 and 2015 Rugby World Cups. He is widely known as “The Snake” for his ability to slip through tackles. At 38, he captained the Wellington-based Hurricanes in the Southern Hemisphere's Rugby league, then retired after the 2015 World Cup.  He now serves as legal counsel and project manager for International Rugby Players, the global representative body for the sport. He is also the high-performance manager for Pau, a French club that competes in the Top 14, the highest in the country's domestic league.  Find out more about Conrad and his work at International Rugby Players.    Enjoyed This Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends, so they can learn what to do when they feel pressured.  Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa     Transcript Of The Podcast Welcome to Pushing the Limits, the show that helps you reach your full potential, with your host Lisa Tamati, brought to you by lisatamati.com.  Lisa Tamati: Lisa Tamati speaking. Welcome back to Pushing the Limits. This week, I have Conrad Smith, the famous, famous All Black, who many of you Kiwis at least will know, a superstar athlete. And we share information about his career, and what it's like to be in the World Cup, and lots of exciting stuff. Also, what it's like to be post-career now, retiring, some of the issues that he sees around young athletes. Really lovely and interesting conversation with the amazing Conrad Smith who's also a lawyer as well as an All Black. Talk about an overachiever.  Before we get on to the show, just want to remind you, we have our epigenetics flagship program that we're running constantly. So if anybody wants to find out what the genes are all about, and how to optimise your food, your exercise, your lifestyle, your chronobiology, your mood and behaviour, all these things to your specific genes, and get the blueprint and the user manual for your body, then please come and check out what we do. Head on over to lisatamati.com, hit the ‘Work with Us' button, and then you'll see our Peak Epigenetics program. That will take you over to our site where you can find out all about that. Or you can always reach out to me, and I can send you a little bit of a video, and maybe jump on a call to explain how it all works. It's a really powerful and awesome program. We've taken hundreds and hundreds of people through this program, and it's really been life-changing for so many, including myself and my family. So if you're wanting to find out about that, just head on over to lisatamati.com and hit the work with us button.  Also, just wanted to let you know that I do a lot of motivational speaking, corporate speaking. I would love if anyone knows, or organising a conference, or team workshop, or anything like that, please reach out to me: lisa@lisatamati.com if you're interested in finding out about my speaking programs. Also, we do corporate wellness programs on that front as well. How can you upgrade your life and be the best version of you can be at work and at home? That's what we're all about. So thanks for that letting me do that little plug.  Now, we're going to be going over to Conrad Smith who's just been moved back to New Plymouth. I've had the privilege of meeting him a number of times and working on a couple of things. So I hope you enjoy this conversation. Now, over to Conrad.  Well, hi everyone and welcome back to Pushing the Limits this week with Lisa Tamati. I am really excited for today's conversation. I've teamed up with another amazing superstar, a top athlete for you guys to enjoy learning from today. I have Conrad Smith. Conrad, welcome to the show.  Conrad Smith: Thank you, Lisa. Thank you for the introduction.  Lisa: You hardly need an introduction especially to people living in New Zealand. A legendary All Black. You played for how many years? I think it's 2004? Conrad: 15 years. Lisa: 15 as an All Black, as a winger. You've been a captain of the Hurricanes. You've been, I don't know, Player of the Year and Sportsman of the Year in Wellington. Your accolades are such a huge list, Conrad. You're blushing already, I can see. But really, an incredible athletic career and you were also talented as a cricketer, I understand. Conrad: When I was a little fella, when I was little fella. I was too little for rugby so I played more cricket, but yeah.  Lisa: And then you grew. Conrad: I was a New Zealander. New Zealand kid back then. Yeah, then I grew up. That's right.  Lisa: Yeah. Then you grew up and you were big enough to take on the big boys. Say, Conrad, give us a little bit of a feel like where you grew up. And how much of an influence did your childhood have on what you ended up doing with your rugby career? Conrad: Yeah. So I was actually born down Hawera. My father was a policeman so we moved around with him a little bit in the early years, and then moved to New Plymouth when I was about six. We're a very, very close family. He gave a lot of time. My mom and dad would always make time for the kids: a couple older brothers, younger sister. Yeah, it was a great childhood. A lot of sport was played but we all did pretty well academically, which my parents laughed at because both of them never made it. They did poorly in school. Really, really supportive parents in terms of... It's funny, I probably took it for granted then, but I don't ever remember my parents either not being there or having to work.  Everything we did, we always were supported. And they were there, whether it was just drive us there, or coach our teams, or try and help us with our homework. I think that was what I've, like I said, took for granted but now, being older, I realise how important that was and why we're still such a close family, and my brothers are my best mates, and my sister is. We still meet. Yeah we still, obviously. We're all sort of have moved around the world but we're sort of pretty close together again. I suppose I try to be now with my own family like my dad was to me. Yeah, so those were the luckiest break in my head, I suppose. I always say people talk about luck, especially in sport but for me, it was just the family I was born into and the sport I had as a young fella.  Lisa: Yeah. Now, that's brilliant. And you had a couple of kids yourself?  Conrad: Yeah, yeah. Now, we've got two of them, just about to go off to school. Luca is my seven, and we had him in New Zealand, and then our daughter was actually born over in France while I was over there for four or five years. She's come back with us. Lisa: Growing up in the... You grew up in the 80s, I grew up in the 70s. Showing my age, yeah. But I think in the 80s, it was still very much like an outdoorsy lifestyle, like that good Kiwi kid upbringing, especially in Taranaki because we both come from here. Having that being outdoors in nature all day, as kids, we never came home before dark, sort of thing. Was it the same in your household?  Conrad: Yeah, for sure and like I say to all the brothers, they were pretty influential in what I did. I just sort of hung around, tail off them but very much, we were always out. I just think of my childhood, it was all about playing sport, finding areas to play sport. You'd sort of get pushed out, and as we try and play inside, then we'd get pushed out to the garden and we'd ruin the garden or ruin the lawn. We're just constantly finding places to do what guys do with a ball and you can do anything. Then, the wider family were farming so my dad was on the farm. He sort of got kicked off by his older brother, but that was a family farm.  So we would eat out that way and that's that Douglas from Stratford on the way there with my mom in there. That's been in the family for three or four generations and that would be where we're kids. We'd help with haymaking, we'd help with carving, we'd help all sorts. That was pretty much my favourite holiday, and the same as all of us kids would be to go spend some time there and help on the farm. That was just a childhood, yeah. You just know what friends to do and always outside, didn't matter if it was raining and cold as it often is at most parts. We just put a coat on and carry on.  Lisa: Oh, man that just takes me back to my childhood, and I often think, 'Man, I want to go back.' What happened to that simple life that we had when we were kids? You're very lucky to have such wonderful parents, obviously. It's such a cool family. You also went off into university and became a lawyer, as you do, as an All Black. A slight overachiever there, Conrad. Did you always want to be a lawyer apart from wanting to be an All Black?  Conrad: As I sort of said before, I wasn't a huge overachiever on the sport front. Well, I went to Francis Douglas; it's not a huge sporting school. We had sporting teams, but that wasn't very much. Part of it, you were there to study, you were there to get an education, and I enjoyed it. I enjoyed school. I think it is a great school, and a lot of my mates now are still from the mates I made in my school years, and yeah. So I didn't mind class and I never had a... I suppose leaving high school as it was when I was going to go to university, my brothers had both done that. That was sort of a thing to do.  Law was, yeah. It was something. I enjoyed English history. Those sort of subjects at school in Wellington wasn't too far. I sort of wanted to go down to meet my brothers down there and that was the scarfie life was. But he sort of talked me out of it just because he... I think he'd done about four years by that stage, and flying down, and getting himself back and forth was pretty tough. They sort of said, 'Well, if you have to, go closer to home.' and that was when I ended up in Wellington and I really enjoyed law and rugby.  Yeah like I say, sport was great, but it was two nights a week. It wasn't taking over my life as I know it does to a lot of kids nowadays. They make academies, and whatnot, and maybe talk about whether that's a good thing or a bad thing. But yeah, I was able to finish a full law degree and luckily, that sort of perfectly dovetailed into when I started playing professionally. Yeah, it was just sort of fortunate for me in terms of the way it all worked out and the timing. That's something I was very grateful for, obviously. Lisa: Yeah, yeah. Because right now, like your career, your playing career at least is over, you've got something to do. You've got a qualification. If we dive into that subject a little bit, so a lot of the young guys now are coming through and they're sort of getting picked out early along the way. What sort of dangers do you see with that system?  Conrad: Yeah, I do worry about it,  and I've spoken about it before. Because it's not just in rugby. It's in all sports. There's sort of a real obsession towards identifying talent young. Then the excuses, are you giving them the best chance of success? So we're gonna do all the work with them, and specialise them, and make them concentrate on the sport. But firstly, I don't know if that actually helps them with their sport a whole lot. I think it's fine to keep a balance, and to play other sports, and to experience, just live a normal life. I think you can still excel. But the other thing is that if it doesn't work out or even if it works out, sports are short term industry. You know, I know that that's not forever, and when you get to the back end of that, if you're purely invested in one sport when the time runs out, you got to rebuild a lot of the... Yeah and that's a real problem.  And you don't need to look far to find a lot of evidence about that. We've been afoot and looking at American sports because they've been professional a lot longer than we have. Some of the statistics is just shocking. And people would think that they paid so much money, the athletes in those sports in America that they should be able to live literally after... They could do whatever they want. Theoretically, they have enough money just to retire but the statistics are not that at all. You have a crazy number of bankruptcy, crazy number of rates of depression because they haven't learned to live outside of their sport. That's sort of been taken away from them because they're placed into their sport so young, and then just cut, and there's no real assistance around that.  So yeah, that's an extreme example and we're nowhere near at that stage here with the way the academies and that are set up. I know most of the people involved are very mindful of the things I've just talked about. Lisa: That's pretty...just open that conversation now. Conrad: Yeah. I just think there's a lot to be said around leading young people. I look at myself and from that period of development where maybe nowadays, I'd been in an academy, I was lead to play multiple... I played cricket, I played basketball, I ran, I did, God knows, all these things, and who's to say what lessons I learned from those other sports that I actually used in rugby? Because there's so much that you can pick up and also being able to study.  For me to have a degree, the benefits that gave me to deal with injuries, to deal with all the downsides of sport because I had a background and the education. It's really helpful. You relax a lot more. You get a perspective on the sorts of things that if you're just wrapped up in a sport and you get an injury, man that's tough. You can't do what you would like to do. Where do you turn? But I think if you've had a bit of an education, and it doesn't have to be a law degree, but if you've got some other life or other opportunities and options that you can turn to in those times, and it gives you perspective and a sense of reality, and you don't get so caught up in that, so yeah. I know it is appreciated. I just think it may be still underrated by a lot of the people that are setting up these academies and things for the young sportsmen.  Lisa: Yeah, and that's a good conversation to have and just be open about. Because you're one injury away from ending your career at any time. And then, to build... that's like building a sort of a house on a foundation of saying if you haven't got something else and you haven't got the life skills, if I just look at the opposite extreme with my sport where you have... When I started, just a bunch of weirdos doing crazy stuff, right? There's no structure, and there was no support. There was no knowledge, but it taught me that I had to go and market myself. I had to go and push everything that... Even when I represented New Zealand, I had to buy my own singlet to wear at the thing. Get a little... I'm getting here and do all of the things. So you had to market yourself, present yourself, become a speaker, do all of this sort of stuff in order to... So through that, you learn a lot of life skills anyway and then it was never a professional sport, in a sense. I managed to live off my sport for a number of years, but that was an exceptionally... That just because I found ways to do that but it wasn't a pathway that anybody could follow. But it taught me to fight. I remember having this conversation with my brother, Dawson, who I know was one of your heroes when you were a little feller. My brother, Dawson, was a Hurricanes player and Super Rugby in Taranaki and international as well. When I came back from Australia, and I came back to New Zealand, and I was raising money to go to Death Valley, which was a big race for me, he was like, 'Why are you in the media? Where you want to be? I used to hide from the damn media.' And I'm like, 'Yeah, but you got everything given to you, mate. You got all your clothes, all your gear, you got stuff gifted to you left, right, and centre. You've actually got no idea what another sport is.' That structure, that framework is not there. And that's good and it's bad.  When you have everything laid on for you, but you haven't had to fight in society for your things... Because I've talked to a lot of rugby clubs actually around the country to all the younger guys. Everything is laid out for them. They have to fight. They've got a lot of pressure as far as performance and all that sort of stuff goes, but the rest of life is sort of taken care of. So it's something to be wary of. I think you got young ones and going up through this system is to just think about, 'What is the fallback option here? What else are they going to do when their career is over?' Because it can be very short, and not everybody reaches the stardom that you did. Not everyone gets to play for the All Blacks' 94 games or... Conrad: We talked about the bubble. They use that term a lot within sports. So you come into this bubble. When you stay in that bubble, you lose touch with reality. You're actually... I know because I've seen it, and I'd use that same terminology and say, 'Come on and talk to the guys. I've got to get out of the bubble.' It was always a thing of because people would... And you'd see it with people that get drawn into a sporting career and if they're doing really well. And you're right. It's only in New Zealand that it's probably only really rugby. There are other sports now that get paid really well, but they have to head overseas so... You're thrown into a lifestyle where everything is laid on and you don't actually... You forget how the real people live and the real life is, and that the bubble bursts, and it all comes about, and this is what I'm saying: The more time you spend in that bubble, when it bursts, the harder it is. The fall can really take a lot of getting used to it and some people don't.  Unfortunately, even the guys I have played with, I've got as many stories of guys who are struggling, still struggling as the guys who fell on their feet. I don't think anyone does straight away, even myself. People will say ‘You handled it well.' I've been retired just over three years and I knew. Everyone seemed to me it's at least two years before you even... There's still things you struggle with it. And that was spot on. It just takes a lot of time to understand that you're never going to get up in the morning and have that same drive. You're very lucky that when you're as a sportsman or woman to have that drive. Just do the same thing. But you got to find something else, and it will never replace that and it's not meant to, but it's a challenge for everyone. Those life experiences during that sporting career are so important so that when the bubble bursts, when you come out of it, it's just a little bit easier to find your feet. Because otherwise, that is tough, and it's a bit of a worry.  Lisa: Yeah yeah exactly. Just on even from that identity of being this athlete and you had a singular purpose. Pretty much every day when you got up, it was to train and it was to be the best for the next game or the next whatever. And that gets taken away and then the complexity of life comes in. Yeah? I retired from doing ultramarathons at 48. It's a sport where you can go a lot longer, and I've got mates that are still in their 60s and 70s doing it. But what I do see often in the ultra running community is they don't know anything else so, 'I'm going to stick with what I know and I'm just going to beat the crap out of my body until it falls into the ground.' Rather than going, 'Hang on a minute. This is no longer conducive to what I really want for me.' And reassessing. With rugby, you're forced to because physically, at 48, you wouldn't be able to keep up with a 20-year-old.  There's that whole, have you struggled? I know I've struggled with that whole identity. Like, 'Who the hell am I if I'm not that hardass athlete and I'm not able to do what I used to do?' Because I still get it in the running scene, 'Oh, a marathon must be... you must do that before breakfast.' I'm like, 'Yeah, no. That's not...' Now, a 5K's quite long. You know what I mean? So your horizon comes back in. So I've spent decades pushing my horizon out to be able to go longer, longer, longer, bigger. Then, life happens. In my case it was mum and that was the end of the career. It was high time; it was overdue. But that whole, you just had the rug pulled out from under you, and your identity is tied up in that performance. Have you found that a struggle?  Conrad: Yeah. Yeah, I think. Like I say, everyone does. You're lying if you say people do it easy. Again, I think a lot of the work, hopefully, athletes that handle it better have thought about that work during their career and they don't... We were given some great support while I was playing, particularly, within the All Blacks, guys like Gilbert Enoka with the background. And the whole mental side of not just the game, but of life, in terms of keeping...being grounded, keeping perspective. Part of that was your identity and not letting rugby define you. We used to say that you're a person that plays rugby, you're not a rugby player. It has this other life. You're actually... I play rugby because I like playing. Maybe that's not who I am. That's what the public sees, and I think if you get a handle on that while you're playing, then you understand that when rugby is taken away but that's not part of... ‘That's what I used to do. Now, I'm not doing it anymore but I'm still the person I've been this whole way. Now, my journey carries on.'  Like I say, that's easier said than done. There's people that become the rugby player. That's all they are, and so that's the real challenge. For me, it was about just finding other challenges. And I think anyone in terms of rugby or any sport yourself, you find other challenges, it gives you... You realise your own identity and you find other things to do that give you fulfilment. I think aligned with that is the whole... When I think of rugby players, a lot of them who find the identity in rugby, they then just go on to coaching, and this is a real problem, and it might... I don't think that's just with the sport of rugby, but you have a lot of retired players that feel like they have to coach because they think it's all they know.  The challenge, I suppose is, then of being careful not to fall into that trap. It was easier for me. I studied. I used to be a lawyer. I'm sure I could go back and do that. Maybe not as a lawyer, but there are other skills that I have. That's a really hard message, but it's a really important message to give all sportsmen. To rugby players, I'm always telling them, 'You don't have to stay in rugby, you know. You played, you finished, you don't have to coach.' There's going to be hundreds and thousands of players finishing career and they think they have to coach. But their skills are transferable to hundreds of different professions and things that will pay them well. You can keep being yourself.  Even for me, I've stayed within rugby but it's not coaching. I'm working with the Players Association, International Players Association and that suits me. That's my skill set: a bit of the law, the analytical side of me that I've always had. And I think that was important. It's sort of my process of moving away from that identity as just 'Conrad Smith, the rugby player.' It's important to find other things that challenge me and that I enjoy. Lisa: Just interrupting the program briefly to let you know that we have a new patron program for the podcast. Now, if you enjoy Pushing the Limits, if you get great value out of it, we would love you to come and join our patron membership program. We've been doing this now for five and a half years and we need your help to keep it on air. It's been a public service free for everybody and we want to keep it that way. But to do that we need like-minded souls who are on this mission with us to help us out. So if you're interested in becoming a patron for Pushing the Limits podcast, then check out everything on patron.lisatamati.com. That's patron.lisatamati.com. We have two patron levels to choose from. You can do it for as little as 7 dollars a month, New Zealand, or 15 dollars a month if you really want to support us. We are grateful if you do.There are so many membership benefits you're going to get if you join us: everything from workbooks for all the podcasts, the strength guide for runners, the power to vote on future episodes, webinars that we're going to be holding, all of my documentaries, and much, much more. So check out all the details: patron.lisatamati.com. And thanks very much for joining us.  Lisa: That's awesome and thanks for sharing that because I think that's... Being able to openly have these conversations because there are a lot of athletes in lots of different sports struggling with this whole process of... Your career is so short, and you're not a has-been. I asked myself these conversations, and most especially in the beginning is, 'You're nothing now. You're a has-been now. You can't do it.' And being embarrassed about that, instead of going, 'Hang on a minute. I'm still pretty fricking epic and I do other stuff.' Now, that's freed up a huge piece of my brain and my daily power and energy to then go and attack other massive projects.  There's so many things in the world that you can take on. It's all up to you to develop a certain passion. And I think it's not even just in the sports realm. I see people who are in careers that got friends and careers, they don't want to be there anymore but they studied it, they became it, they did it. whatever it was. Now, they're like, 'Is that it?' It doesn't have to be it, no. We live in a day and age where we can actually go and retrain. In fact, we have to be adaptable and flexible in this day and age if we want to keep up because the world is changing so fast. So many jobs are going to be gone and whole industries.  As a jeweller in a previous life, that industry got destroyed, really. If you weren't in the big game with big brands and Chinese mass production and stuff like that and you're an artisan, a person who made one-off pieces, you're struggling now unless you really got the top massive diamonds and God knows what. Everyone else is struggling, so you have to go, 'Okay, that industry's change. I'm going to have to adapt, change, go with it, overcome it, improvise, and keep developing.' I think that's the message that we're getting here is you don't box yourself in. don't just be that one-trick pony. That's not, and Conrad is now an advocate, he's a father, he's a speaker.  Whatever you decide that you want to be, you can become. And you're not just Conrad, the All Black. I think that's a really important transition for everybody to go through. Even if you're a policeman or a teacher and you don't want to do that anymore or whatever the case is. Conrad: Yeah, and it takes a bit of courage. Like I said before, it's easier said than done a lot of the time. And that's what people just need that encouragement. Especially with finances and people suddenly are, 'I've got a mortgage on a house. I don't want to change career because there might be a layer where I'm not earning money.' But yeah, I just think that's... You come back to some questions about who you are, who you want to be, and you've got to be... You'll be happy doing what you're doing. So I just think all the help you can get from people around you, that's where you'll draw the energy, I think. If it's a conversation you're just having in your own mind, you will never get anywhere. You just need to open up about it, speak to people close to you, and I think that's generally where the answers come from.  Lisa: Yeah. I think that's gold. On that point, how big is mental health in your work? Do you do a lot around supporting mental health, and that sort of thing, and helping people transition, and all that sort of jazz?  Conrad: Yeah, absolutely. More and more, it's a complex field. When you talk about players in the game, in the sport of rugby, it's really difficult. We were starting to appreciate the pressures I think that sportsmen and women are under in these fields. It's a lot of… it draws that back on what we were talking about before. You're in a bubble and you do lose perspective and so not as the... The challenge is to help these young, these kids that are in these bubbles to speak different, and keep living, and look at sport as this amazing opportunity, and not feel the pressure. Well, maybe saying not feeling the pressure is the wrong way to put it because it's natural, but to feel the pressure and find a way to deal with that, a healthy way to deal with it. Again, I look back on my career and you're playing for the All Blacks, you're playing World Cups, it's easy to talk about pressure. There was never times that I didn't know how to deal with it, and that was from the sport I had, and maybe the background, and my upbringing. But it was easily... You just channel that and see and look at it differently and decide. Look at the opportunity that every time you feel pressure, you get it, it's as simple as just changing the perspective of things rather than the pressure of, ‘You have to win'. ‘I'm an All Black, I want to win because…' Whatever. ‘I've got a country behind me,' and suddenly, it's a burden that's lifted and yeah, you flipped it and you're puffing out your chest, and you want to do it. If it doesn't come off, it's a game. There's more important things, absolutely, around. But yeah, like I keep saying, it's not easy for everyone and there's people that understand that better. The challenge is getting through to people of different backgrounds, and different cultures, and different ages.  Lisa: Yeah with different problems.  Conrad: Yeah. I'm saying that because I know what works for me, but I know a 17-year-old young Samoan boy who's playing rugby, I don't know for the Highlanders, I might not be able to connect with him. The things that worked for me won't work for him. That's what I'm trying to say. Or the female swimmer who's doing, training for an Olympics. We're all different, and the challenge is finding a way for everyone to deal with that pressure and to be mentally healthy through a sports career. Lisa: I love that approach and just coming off the back of the Olympics. It was just wonderful to watch our amazing athletes doing amazing things. Lisa Carrington just blows me away. She's mentally just insane. But I love that thing of the challenge versus threat. I think this is a really important thing to do. When you're feeling overwhelmed and overburdened and like the whole world of pressure is on me, you going out and something the World Cup, were you able, even in those extreme pressure moments, to turn that into an opportunity and not a threat? Because that does change the physiology. Like when you're running on the paddock on those days, those couple of times in your life where it's just been horrifically big pressure, how did you physically and mentally cope there?  Conrad: Yeah, I think we've spent a lot of time, and everyone did, preparing for that World Cup. Again, as All Blacks, you have to spend a lot of time because you know the pressure that comes with and the expectation that comes with being an All Black in New Zealand. But even more so a World Cup, a home World Cup, when we hadn't won, I think 2011. A lot of our preparation time wasn't just being on the field with how we're going to play but was how to deal with that pressure. For me, it was just constantly turning it around so that it was never a moment I even... I can look back and think of times in the game where the team was under pressure and it would be perceived as... Even in that final hour, the team struggled a bit with the pressure, but if I'm being honest, our preparation never let us feel that way. We were dealing with that all the time.  We just were focused on doing our job. We talked so much about whatever comes our way, we were going to adapt and deal with it and that's what you just had to keep doing. You never sort of stop, and you'll notice yourself, you just don't let yourself stop and think about that. I think if you've got to that stage, it's too late. If you're having to go through a process of. 'How do I deal with this?' It's probably too late. You've already, hopefully, got a process in place where you're just, it's just instinctively, you're just channelling that, focusing on little details. Because you know whatever the pressure, that's not going to influence you unless you need it. You just focus on the small tasks and you get through 80 minutes of rugby like that, keep a smile on your face. Lisa: Pull your focus into the job at hand instead of the: 'Oh my god. Everyone's watching me. Everyone's pressuring. Hang on a minute I've just got to pass this ball right now.' You're breaking it down into little tiny... Conrad: We all have little trigger words and I know we've talked about this: ‘Be in the now.' Be in the now, which is like just what you're talking about. It's not thinking about the mistake you might have just made, the ball you drop, the tackle you missed, and it's not worrying, and you're not thinking about the World Cup, you're going to win at the end of this game. Because you can't do anything. Right now. ‘Right now. Right now, I'm going to catch this next ball.' Look up, keep looking, keep calling, whatever it is. It's as simple as a little thing like that that just keeps you in tune with the moment and not letting you get overwhelmed by the bigger picture. Yeah, massively important, obviously. The bigger the moments and the bigger the pressure, it's the funny thing, it's the more important that you focus on the smaller, minute detail.  Lisa: I love it. I said try to forget the consequences of what you're doing. You've done the preparation. You've done the work. You've done everything that you possibly can. You're standing on the start line, in my case, a race, then letting go of the outcome because you've done what you can do. And now, it's up to the whatever happens in the next few hours or days, in my case. So this was no longer just in your hands then. Because the gods have a thing to say about it as well. Sometimes, if you try and control the uncontrollable, then you'll drive yourself to madness, whereas if you can go, 'I've done the stuff that I was responsible for. I've put the work and I've done the preparation. I know my strategies. I know my pacing. I know whatever it is I'm doing. I got that right. Okay. I'm going to keep my eye on the ball here. But I'm going to let go of the outcome now.' Because when you let go of the outcome, then that pressure goes and you're in that...  Being in that now is a really powerful message to people. Because when you're in the past or the future, you're either worrying about the future, or you're regretting what's happened in the past, or it's a load for you to carry. In the moment, when you're under pressure, all you can cope with is that second right now. The next minute. That's it. When I was running long distances, I would break it down into: 'What's the next power pole? I just got to get to the next power pole. If I can't even get that far, I'm just gonna take one more step.' You can always take one more step, right? If you break it down into one more step, just one more, and then you just keep going and keep going. Then, invariably, that mindset or that thing that's in your head passes, and then you're back in the game.  Conrad: That's funny, you sound... because someone I remember that came and spoke to the team when we were outside joined the team in 2004, and we had Amish Carter came and spoke with the team. It was before the 2007 World Cup and obviously, that World Cup didn't end well, but some of what he said, I still remember it. He was talking about his Olympic performances, and he said, and I think one of the questions from the players was about we're talking: the nerves and the pressure. And I remember him saying that he wasn't nervous. He wasn't nervous when he got to the start line just for the reasons you said. He said: ‘Because then, I'd backed on my prep, I'd done everything I needed to do. Now, it was just a matter of going out and doing that. You can't do anymore.' It's funny that when I looked, especially towards into my career, the only times I would feel nervous normally, on the start of a week. So if we play the game on a Saturday, and that was because I'm nervous thinking of all the things I've got to do on the Monday, Tuesday. But by the Friday, I would have this real sense of calm. I'd have a smile and I'll be like, 'Right now, it's time to do it.' It's funny because people, it's the opposite. They're not thinking about a game on Monday, Tuesday, but they were getting nervous on before a game starts thinking, 'You must be even worse.' But yeah, that was the way I could explain it is that we're really... I was nervous thinking about the game but now, I've done all that. This is the path I've taken. This is the training I've done for this game. Now, I'm ready to... I'm going to go and do it and see if it works. Lisa: Yeah, this is the reward phase. This is actually what you've been preparing for all along, so this is the time when you actually should be enjoying it. It wasn't always that easy especially when you're doing a couple hundred K's somewhere because sometimes it's not that pleasant. But you've done the work to get to the start line and the times where I am being nervous is when I hadn't done the work.  Conrad: Exactly. I think of some... I don't like admitting it but normally, with All Blacks, you always have checked every box but there were games, I'd go back even the Hurricanes or Club Games and that's the ones where I'd be nervous because I'd be thinking... ‘I haven't really... now this week. I probably haven't done…' Then, you get nervous but actually the bigger the occasion, the preparation is normally good.  Lisa: You took it seriously and yeah, yeah. I've come stuck on some short races where I've had my ass handed to me because I went in with the... That's just the short race, and oh my god. Had my ass handed to me. So yeah, always respect every distance or every game. I think it's key. What's it actually like, Conrad, to be... The first time that you put on that All Blacks jersey? Because it's every little boy and now, little girl's dream too. What's it actually like to put on that sort of thing for the first time? Can you remember?  Conrad: Yeah for sure. It's pretty special. I do think I was really lucky the way it panned out for me in terms of... It happened really quickly. I'd play. I hadn't even played the Super Rugby game. I hadn't played for the Hurricanes. When it started, I had a really... I was playing for the Wellington Lions. We made the final, and then I was picked, fortunately. So the coaching staff that had come in wanted to pick some new younger players and I was one of those. That was very much sort of out of the blue. Then, I was starting the following week. So I played a final. The team was picked. We assembled the end of that following week. We flew to Italy, and then I was playing.  But that was great in hindsight because it didn't let me overthink that. It was sort of okay, and I just was like, 'Right.' Little bit like what I said before, 'I'm just going to enjoy it.' Admittedly there were people around me. Graham Henry, Ryan Smith, Steve Hansen, great coaches, and Gilbert Enoka that were giving me those messages. Just telling me, 'We're picking you in the first game. Just go and enjoy it. Just keep doing what you're doing. We love what you're doing.' So those messages for a young guy were perfect. I didn't actually question that. Yeah, I just took the jersey. I was still sort of pinching myself how quickly it happened. But yeah, then there I was playing and yeah, it was an amazing experience.  I'm glad to say it never really diminished. I was lucky to play for over a decade, and it was always special putting on the jersey. The team does a great job, I think, of respecting the jersey, acknowledging how important it is to their country, what we mean to everyone, and staying grounded, and all that good stuff about acknowledging the connection that you have with the young men and women who are dreaming to being All Black, wishing they were there, would give anything to be in your place. So you're always aware of that, and so it never loses its glow. Then I put my jersey on.  Brian Hoyer who was a big part of the team when I joined the team, he said ‘When you put the jersey on, you shouldn't be able to fit outside the doorway.' You grow that big. I'm not using the words and I always... For me, I was normally marking someone bigger than me or normally not the biggest in the room but I always felt that. That I have to turn sideways to get out the door but that was the sort of feeling and you hear that even today: The way you sort of, you grow in the jersey. Lisa: You're carrying the manner and the tradition of that, and the reputation of that, and the hopes of a nation, basically, on your shoulders, which can be either a load or it can be like, 'Wow, how lucky am I that I get to stand on the shoulders of those who have gone before?' Basically and like you said, 'Yeah, I can't fit through the door because I'm just filled with all that.'  Okay, just a very quick anecdote. I was running through in the Gobi Desert at one point and we were running through these slot canyons. These really crazy. It was hot. One guy died out there that day which was really terrible. I was running through there and I was chasing down this American woman who was in front of me and I was second. I'm like, 'I've got to plan something here if I want to beat this person in front of me that I was chasing down through these canyons.'  So I started singing the Maori Battalion song to myself and I started to... like my ancestors, and my tradition there, my heritage like, 'I'm going to bloody beat you, American. Yeah. I'm gonna chase you down, and I'm singing away to myself running along through this canyon.' I beat her, right. It was awesome. I just went dashing past her, and I beat her. But it was just like, 'Wow.' It's just like you're pulling out stuff that you... It's not just you. You're like your ancestors and your heritage, and they're powering you. So I imagine it's a bit the same with the All Blacks jersey.  Conrad: Yeah. It's powerful stuff. Like, and it's all about creating something bigger than you. There's no doubt the history of things or like you say, in individual sports. As soon as you can create that connection to a greater cause. Actually, in the All Blacks, it's actually easy. I say this when I talk to other sports teams around how they create the identity. But the All Blacks had it handed to them because they have 130 years of whatever it is of this amazing performance, of this history, this black jersey that this country that's mad obsessed with them, great air of success and also, this idea that we do unite. We're the flagship of New Zealand. Rightly or wrongly, that's the way we're saying and you got to embrace that.  The fact that every time an All Black teams practice, it's a culture we have in New Zealand. This great collection of men who are representing the country. You capture that in the right way, and it counts as something. The field is 00 but I always felt... Yeah, when we got it right, we're straight away. That's worth some points at least on the board. It's something special that the All Blacks do have, and to the credit of the team, the whole time, I was involved. I know that it's carrying on that the way they connect and acknowledge that, it's really well done. It's the reason that the team continues to perform well. Lisa: And it does it empower whole generations. Like I said to my brother Dawson, my dad wanted him to be an All Black, and he wanted him to meet all those milestones along the way. I remember like... We lost my dad last year, as people know, if they listened to my podcast. I said to my brother the other day, 'Dawson,' because he went to the game up at the park, at Pukekura Park and they had the 25-year anniversary for the Ranfurly Shield because he was on the Ranfurly Shield team. He was excited to go to the Ranfurly Shield thing, and I remember that being the proudest moment of my dad's life. Of all the things that my dad got to do and see, all of their kids, I said to Dawson, 'You gave him the highest point in his life was when you came home with that Ranfurly Shield, and you're a part of that Taranaki Team. That was, for him, the pinnacle.'  That's beautiful because that is just like... Especially when you've lost somebody... And Dawson's like, to be able to go and celebrate that Ranfurly Shield with his old mates and reminisce on those times. That stays with you to the end: those special moments that you get, and that camaraderie that comes with it, and all of that sort of stuff. He gave my dad a precious gift really by being a part of that team. Dad was just so proud.  Dawson said to me once, 'Lisa, you could run across every fricking desert in the world and it would still not mean as much as that Ranfurly Shield.' And I said, 'You're damn right, and that's okay.' Because he was right in that. It's okay because he loved rugby, and he loved rugby teams, and the rugby world. My dad played, what do you call that? Fifth-grade rugby until he was 45 and he only quit because people were telling him he was too old, and then he played touch for another 10 years. He was a legend. A legend.  You're carrying all that on your shoulders. There are five and six-year-old kids looking at you on screen like you did with Daws back then. Like, 'Oh, these big Taranaki players and stuff.' That's just beautiful. I had that just wanting to represent New Zealand in something because I couldn't be in All Blacks because back then, we didn't have women playing rugby, much to my dad's disappointment. Actually watching the girls at the sevens in the Olympics, oh, I just fell in love with that team. They were just epic. Ruby Tui is my new bloody hero. She's just amazing. I think she's just epic. But just to watch the camaraderie of those girls and the performance that they put on, I'm glad that women now have the chance to do that tough stuff too. Because that's pretty special as well: seeing girls going there and giving it everything, just going hard.  Conrad: You speak to the Black Ferns, the women's rugby, it's growing so much not just in New Zealand, but around the world and that's pretty exciting, especially for Fifteens and the opportunity it's giving so many young women. Yeah and so for myself, that's really refreshing now with international rugby and the Player Association and we deal with both men and women's. The joy I hear working in women's rugby, seriously, compared to men's, especially men's Fifteens, it's a lot of established... Careful with my words, but it's just so hard. To put it simply, it's so hard to get things done even if you agree there's so much.  Whereas in the women's game, it's so refreshing. There's just an openness and the enthusiasm. They just, 'Yep. Let's get that done and this.' You will see, women's rugby going to go great in the next few years, and it's because of... In the men's game, I don't like to say it, but it might not have anywhere near the same growth or evolution just because it's... Lisa: Stayed in the old ways. It obviously breaks everything, isn't it?  Conrad: The money, the money at that level is so big that there's so much at stake. That's just what grinds along, whereas the women's game, they're not... Obviously, they're trying to commercialise on the game, but it's crumbs compared to the men's for things at the moment. But they'll catch up at a huge rate because they're just open about... Like at the moment, they're motivated by having fun, being patient, at getting the product out, getting more and more women and girls playing the game.  Lisa: That's amazing and isn't that though that's a really good analogy for everything in the world? Like that the big old institutions or big bureaucracies are going to be struggling in the future, I think. Completely off-topic but from the governments, to the big corporations, to the big institutions are going to be struggling against these young, nimble, small, exponentially powered technology-based companies and the rate of change that's coming that these big state, old bureaucratic, not just talking about rugby here, but governments and things are actually going to be on the backfoot shortly.  I always think of that Kodak, the company Kodak that used to be the biggest player in the world and photography, right? They didn't go with digital evolution, then they went under. Because they were too busy trying to protect what they already had, they actually discovered digital photography. They started it, but they didn't pursue it because they thought, 'Oh, that's going to be a threat to our current existing business.' That mindset is when you get overtaken by the young upstarts that come along with enthusiasm and they can, on a company-wide level, they're smaller. They're nimble. They can make decisions quicker. They can move faster. I see this in all areas happening. Hopefully, in the right way it'll brush off as well, but the girls certainly are next level.  Conrad: They're great. And I've got to know a few of them, a few of the Black Ferns. Lisa: Can you help me out with Ruby? I want to get in with Ruby. Conrad: That is such great Kiwi so yeah, more than happy. She'd love to chat. Lisa: Woohoo. Okay. I know she's pretty busy right now. Everybody in the world wants to see her right now. And the other girls, they're just amazing. Conrad, as we wrap it up now in a minute because I know you got to go, but what is it that you want to get across? So if we highlighted a couple of points now, if you were talking to your children, you've got two kids, what do you want them to do in the future? Or what would you, if you were talking to some young kids out there that want to have a life in the sporting world? What's some last parting wisdom or for the parents of those kids?  Conrad: Yeah, I think if you're speaking to parents, the first thing is the value of sport, I think. I just worry a little bit. I know I'm working in rugby, and there's some crazy things being said about the potential harms of playing a contact sport. But honestly, I've had the benefit of seeing, digging a lot deeper into that and that is not at all as clear as it's conveyed because of the sensationalism of journalism. Kids are kids. They love playing. If I leave my boy and his next-door neighbour, they're gonna wrestle; they're gonna fight. There's no harm in playing.  But on the flip side, the harm of not playing sport, of sheltering them, of thinking, of sitting in a lounge with a Coke and a bag of lolly is better for a kid than going and playing rugby because he might knock his head. That's so far from the truth. That would be my wish for parents' young kids. Just play sport but... And then, I suppose, if it's to reflect on what we've talked about, when the kid means getting serious about a sport, it would be to keep you balanced, to not lose sight. If you're put in a bubble because it's a performance bubble, then that's all well and good but now, it's a bubble and you need to step out of that every chance you get and connect with the real world as much as you can.  Unfortunately, there are dangers and there are risks when you are totally invested into a sport. The crazy thing is sport is a great thing. It should be enjoyed and if you're even not enjoying it, it's not hard just to talk to someone and step outside your sport to reconnect with the people in the real world. Then, that should give you back your love of the game, and then you'll go well and be like Lisa and I and have a life where you've had a sport that you've loved, and it's given you amazing opportunities, and literally meet great people, and you still come out of it, and you're still happy, and still meet people but doing different things. Lisa: This is gold. Conrad, thank you so much for your time today. I really appreciate it. I'm looking forward to doing our speaking gig together shortly and that's going to be exciting. I'm just really glad to have made your acquaintance and I think that you have such a level approach, level-headed approach to this whole thing and gave us some great insights today on what it is to be an All Black, but also what it is to come out the other side and gave us some really good perspective. So thanks for your time today, Conrad. Conrad: Pleasure, Lisa.  That's it this week for Pushing the Limits. Be sure to rate, review, and share with your friends, and head over and visit Lisa and her team at lisatamati.com.   

Chaos a napätie v bezpečnostných zložkách vnímajú veľmi kriticky bývalí politickí lídri Peter Weiss (SDĽ) a Béla Bugár (Most-Híd). V relácii Ide o pravdu podporili snahy koalície bojovať proti korupcii, a obnoviť dôveru v právny štát. Bugár a Weiss sa dotkli aj najnovšej snahy maďarskej vlády nakupovať nehnuteľnosti v strednej Európe. Nákupy by mala realizovať štátom zriadená Nadácia na ochranu vybudovaného dedičstva, a realizovali by sa aj na území Slovenska. Obaja bývalí politici sa zhodli na potrebe urýchlene prijať novú legislatívu, ktorá by nákupom nehnuteľností cudzím štátom na slovenskom území zabránila.

Après 2 ans d'attente à cause du COVID-19, la COP26 va enfin avoir lieu dès ce dimanche 31 octobre à Glasgow. Sélectionnée en mars 2020 pour ce mandat, Nadège Carlier, Bruxelloise de 25 ans fera partie de la délégation belge. À ce titre, elle participera aux réunions journalières de la délégation et y portera la voix des jeunes. En tant que jeune déléguée ONU pour le Climat, le rôle de Nadège, avec son homologue néerlandophone Reine Spiessens, est de porter la voix des jeunes belges au sein de la COP.

Après 2 ans d'attente à cause du COVID-19, la COP26 va enfin avoir lieu dès ce dimanche 31 octobre à Glasgow. Sélectionnée en mars 2020 pour ce mandat, Nadège Carlier, Bruxelloise de 25 ans fera partie de la délégation belge. À ce titre, elle participera aux réunions journalières de la délégation et y portera la voix des jeunes. En tant que jeune déléguée ONU pour le Climat, le rôle de Nadège, avec son homologue néerlandophone Reine Spiessens, est de porter la voix des jeunes belges au sein de la COP.

Nadège WUESTENBERGHS / La police mène une action, les contrôles prendront plus de temps si vous prenez l'avion.

When was the last time you got up and ran? Simply jogging around the neighbourhood during the weekends to keep fit may be daunting for some. Now, imagine the sheer amount of dedication, endurance, and resilience ultramarathoning requires. This type of long-distance running is an activity that tests the limits of human endurance. You might think running a thousand miles is impossible, but today's guest continues to prove others wrong. He's on a mission to exceed his limits and inspire others to do the same. Dean Karnazes joins us in this episode to get up close and personal about his experiences in ultramarathoning. He candidly shares the highs and lows, the triumphs and defeats. We also find out the importance of failure and finding magic in misery.  If you're interested in discovering how you can build your character, embrace pain and failure, and get inspired to push your limits, then this episode is for you.    Here are three reasons why you should listen to the full episode: Discover how to cope with the ups and downs of ultramarathoning. Learn about the importance of pain and failure. Get inspired by Dean's valuable takeaways from his career.   Get Customised Guidance for Your Genetic Make-Up For our epigenetics health program all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/. You can also join their free live webinar on epigenetics.   Online Coaching for Runners Go to www.runninghotcoaching.com for our online run training coaching. You can also join our free live webinar on runners' warm-up to learn how a structured and specific warm-up can make a massive difference in how you run.   Consult with Me If you would like to work with me one to one on anything from your mindset, to head injuries,  to biohacking your health, to optimal performance or executive coaching, please book a consultation here: https://shop.lisatamati.com/collections/consultations   Order My Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Still, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: http://relentlessbook.lisatamati.com/ For my other two best-selling books, Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books.   My Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection.   Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron!  Harness the power of NAD and NMN for anti-aging and longevity with NMN Bio.  A new program, BOOSTCAMP, is coming this September at Peak Wellness!  Listen to my other Pushing the Limits episodes:  #8: Dean Karnazes - The Road to Sparta #183: Sirtuins and NAD Supplements for Longevity with Dr Elena Seranova #189: Understanding Autophagy and Increasing Your Longevity with Dr Elena Seranova Connect with Dean: Website Books by Dean Karnazes:  Ultramarathon Man: Confessions of an All-Night Runner A Runner's High: My Life in Motion Dean's other books   Episode Highlights [05:21] Dean's Lockdown Experience in Australia Dean was supposed to go on a 1000-mile run across New South Wales.  After boarding a jet to Australia, he found that the pandemic situation was getting worse.  And so, Dean and Pat Farmer will be doing their run in a military base instead. Although he's quarantined inside a hotel room, Dean always stays moving and does bodyweight exercises to remain active. It was challenging to go from California, where 80% have been vaccinated, to Australia, which is still in lockdown. [11:18] Chronological and Biological Age Chronologically, Dean is closer to 60 than 50 years old. There are various ways to test your biological age, like C-reactive proteins and inflammation. Tune in to the full episode to learn more about what else goes into calculating your biological age. [14:17] Dean's Greek Heritage Dean's mother is from Ikaria, a Blue Zones with the highest concentration of centenarians worldwide. People in Ikaria live long, healthy lives. They don't pay attention to time and live in a strong community. Therefore, they are not prone to stress. Dean doesn't have any back, muscle, or joint pain. [18:50] Know What Your Body is Built For People are built to run at different speeds and distances. Various factors affect what you're optimised to do.  What's important is knowing the things that are optimal for your health. Dean has run over 300 traditional marathons in his career. He has also seen people well past their 70s who are still physically able and active. [22:04] What is A Runner's High About? A Runner's High is about the changes that he, the world, and ultramarathoning has undergone. Ultramarathoning impacts the people closest to you. Dean wanted to write a true and honest story about his reflections over the past three decades.  [24:00] Running the Western States Endurance Run This 100-mile trail race starts in Sierra Nevada, California. Dean first did this race in 1994. To him, this was an unforgettable experience. Going back after 13 times, Dean found that watching his dad and son crew for him and seeing how things changed over time was transformative for him. Dean recounts his experiences in detail in A Runner's High. [25:54] The Surprises of Parenting Kids grow faster than parents can adjust to them growing up.  Dean describes his son Nick as dichotomous, recounting how he would complain about his roommates being slobs while his own room is a mess. Nick volunteered to crew for him. Dean thought Nick would be irresponsible. Nick surprised Dean; he was much more responsible than Dean's dad. It's a parent's burden to accept that their child is now a self-sufficient, capable adult. [29:58] Did Dean's Career and Fame Affect His Family? Ultramarathoning has always been a family affair for Dean.  He would take his family to where his marathons are. Dean's kids had the opportunity to travel to different places from a young age. Fans that come up to him asking for autographs and selfies are decent people. [34:44] Dealing with Pain and Failure When you're in pain, it's difficult to interact with others. Dean admits that it can be tough when his fans come up to chat with him during this time. He commits to setting aside his ego and always gives 100% in everything he does, including ultramarathoning and interacting with fans. [40:44] The Value of Failing Success builds character, but failure more profoundly so. The emotional range that comes with failure makes one a better human. Don't shy away from hitting rock bottom because you'll be missing out on a profound character-building opportunity. In the end, it's a matter of perspective. Most people will applaud the distance that you run, whether you come in first or not. [44:49] Ultramarathoning is Achieving the Impossible Dean initially thought there was trickery involved in ultramarathoning. The moments that stuck to Dean in his career weren't victories or crossing finish lines.  What stuck to him were the moments when he was on the verge of giving up but persisted through difficulty. [48:04] The Importance of Character Ultramarathoning teaches you to be resilient through the tough times. Running doesn't hurt when you're doing it right. Some people try to avoid difficult things and pain, while others embrace them. We've built our world around comfort, but somehow we're still miserable. However, the more struggle you experience, the more strength you build. [53:21] Dean's Biggest Takeaways From Ultramarathoning To Dean, it's the little moments that are the most priceless. Ultramarathoning is a journey, a passion, and a commitment. Staying true to yourself is valuable, simple, and magical. [56:11] Forming Connections Through Books Writing is laborious, but the motivation it brings to people makes it worthwhile. Dean dictates the things he wants to write on his phone while running.  Running clears Dean's thoughts. To him, motion stirs emotion. A singularity of purpose is achieved when focusing on a specific goal or mission.   7 Powerful Quotes from This Episode ‘Some people are built to run far and slow, and other people are built to run quick and short.' ‘In school, you get the lesson and you take the test. In parenting, you take the test, and then you get the lesson.' ‘What can you do other than just do your best? You're human. All of us can only just do our best.' ‘When I stand on the starting line, I'm going to give it my all. I'm not going to leave anything on this course. I'm just going to be the best that Dean can be. I'm going to try my hardest and the only way I'm going to fail is if I don't try my hardest and don't give it my all.' ‘I think bold failures build character. I have to be honest. Success builds character, but so does failure and in a more profound way.' ‘We've built our world around comfort: having every comfort available and removing as much discomfort and pain as we can. And I think, in a way, we're so comfortable, we're miserable.' ‘I'm just a runner, but that's who I am and I'm staying true to that. I'm going to do that to the grave. And I think in that, there's a simplicity and I think there's some magic in that.'   About Dean Dean Karnazes is a renowned ultramarathon runner. Among his many accomplishments, he has run 50 marathons in 50 days on 50 consecutive days, gone across the Sahara Desert in 120-degree temperatures, and ran 350 miles without sleep. He has also raced and competed in all seven continents twice. Dean has carried the Olympic Torch twice. He appeared on the covers of Runner's World, Outside, and Wired, and has been featured in TIME, People, GQ, and Forbes. He was named one of the "Top 100 Most Influential People in the World". Men's Fitness has also labelled him as one of the fittest men in the world. To top it off, Dean is also a New York Times bestselling author and a much sought-after speaker and panellist in running and athletic events worldwide.  If you want to learn more about Dean, his incredible adventures and his achievements, you may visit his website.   Enjoyed This Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can find inspiration from Dean's stories on ultramarathoning and the lessons he learned along the way. Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You can also tune in on Apple Podcasts. To pushing the limits, Lisa   Trasncript Of The Podcast Welcome to Pushing the Limits, the show that helps you reach your full potential, with your host Lisa Tamati, brought to you by lisatamati.com. Lisa Tamati: Good day, everyone. Welcome back to Pushing the Limits, your host Lisa Tamati here. Today, I have one of my longtime friends and a guy who has had a massive influence in my life both as a role model and as someone who has facilitated me with a lot of help with my books and so on. He's a worldwide legend. He is Dean Karnazes. He is the author of four books. And he has a new one out called the Runner's High, which I was excited to give me an excuse to chat to my buddy, and see what he's been up to, and to talk everything, ultramarathon running. We talk a whole lot about getting older in ultramarathon running, and the difficulties, and we talk about life in general and longevity, and the beauty of the sport. He's an incredible ambassador for our sport. He's done so much. He's brought so many people into the sport worldwide and he's an incredible human being. He's actually stuck in lockdown in Australia right at the moment as we were recording this and was about to do a race ride around Australia with my other friend, Pat Farmer. Another incredible human being. These guys are just next level crazy, and bloody COVID has ripped everything so they're now down to doing thousand-mile race around a military base in Australia in New South Wales. But in true ultramarathon form, where there's a will, there's a way. And when there's an obstacle, you find a way around it. Improvise, adapt, and overcome as my friend Craig Harper always says. So that's what these guys have been doing. So I hope you enjoy this episode with Dean Karnazes. Without him, I wouldn't have my books. He is a very generous and caring person as well as being an incredible athlete. Before we head over to the show, just want to remind you, we have our BOOSTCAMP live webinar series coming up starting on the first of September 2021. If you're listening to this later on, we will be doing these on an ongoing basis. And actually, we have planned to set up a mastermind that goes the year long. I don't know how long it's gonna take us to get organised but that is our goal. We're all about helping each other upgrade our lives and be the best versions of ourselves that we can be. This one's called BOOSTCAMP. This eight-week-long webinar series that Neil and I are doing. This is a live series where you hang out with us once a week for an hour and get a lot of great information: the latest science, the latest biohacking, the latest longevity, everything about mental toughness, resilience, everything that's going to basically upgrade your life and help you be a better human. The stuff that we've spent years and decades actually studying, learning, and doing. So I hope you get to enjoy this with us. You can head on over to peakwellness.co.nzboostcamp. That's B-O-O-S-T camp. BOOSTCAMP, not boot camp. We won't be making you run around doing anything. We're just going to be having wonderful chats and education. A lot of lectures and a lot of fun to be had along the way. And, I think, what's most important is you'll be networking with like-minded individuals. They say that you are the sum total of the five people that you hang out with most. And make those five people, in this case, it will be a few more, some top-quality people who are all on a mission the same as you are. So if you want to come and join us, that's BOOSTCAMP. We also have our epigenetics program. If you want to know all about your genetics, and how to upgrade your life through your genes, understanding what your genes do, if you're dealing with a difficult health journey, and you don't know where to go to next, this is a very good place to start. This is our flagship program that we've been running for years now. We've taken hundreds and hundreds of people through this program. And it's really an incredible all-encompassing program that looks at your food, your exercise types, what time of the day to do different things, your mood and behaviour, and lots, lots more. So come and check that out at lisatamati.com and hit the ‘Work with Us' button then you'll see our Peak Epigenetics program there if you're interested in doing that. Right. Now, over to the show with Dean Karnazes who's sitting in lockdown in Australia. Well. Hi, everyone and welcome to the show. Today, I have my very good friend and absolute legend of ultramarathoning, Dean Karnazes, with me. Dean, welcome to the show, again. Repeat offender. Dean Karnazes: Oh, it's so nice to be back on with you. Thank you for having me. We always have such lively conversations. I love it. Lisa: We do, right? I just absolutely enjoy your company. Whenever I've had the chance to spend a little bit of time with you, it's been absolute gold whether it's been on the podcast, or interviewing you, or hanging out with you on the Gold Coast like we did last year. That was absolutely awesome. Dean, you've just brought out another book. Another amazing book called Runner's High, and that's why we had to get you back on, because I want to share about all this book. But before we get into the book, you're sitting in lockdown in Australia. Tell me what is going on there. Dean: It's a long story but it started with a run across Australia with Pat Farmer. So from Western Australia to the East Coast, and that was the original idea; it was 5,000 kilometres. And this was six months ago when the world was going in a better direction, and over the past six months, boy, the world has done just the opposite. And we, like you, are a fighter and we kept saying we're going to persevere the same... Well, the run across Australia got mixed to a run across New South Wales, a thousand-mile run across New South Wales. And we kept thinking, 'This is going to happen. This is going to happen.' I boarded the plane, I flew to Australia with 10 people on the huge jet, yeah. And when I get to Australia, I realise how bad the situation is here. And every day, I turn on the news. It's getting worse, it's getting worse as I'm in quarantine, and then finally Pat called me a couple days ago and said, 'We can't do the thousand-mile run now. We could still the thousand-mile run. It's just going to be contained within a military base because we need to stay in our own bubble.' And I thought 'Oh.' Lisa: He has flown away from America to Australia to run around the military base. It sounds a bit like being tactic stuff. Dean: Oh, yeah. And not only the... To sit in quarantine. To your point, I've been in our hotel room for 12 days now, waiting to get out, yeah. Lisa: For someone like you... You're just like me. Obviously, you're even more extreme than me. It must be torture. I just can't comprehend being in a room. This must be awful for you. Dean: Don't remind me, but yeah. Basically, from the moment I get up, I'm staying active. We both know the importance of movement. So from the moment my head leaves the pillow, I'm not sitting down ever. Even right now, I'm pacing back and forth in this room, and I'm doing bodyweight exercises just constantly, at least throughout the day. Lisa: I used to... If I was travelling and I was stuck in a hotel room somewhere in a dangerous city or whatever, I'd put on something running on TV and run along with them. I was doing the Boston Marathon in Budapest in a hotel room one day. Just run along the spot. Doesn't matter. You got to do something to keep active, so I can imagine it being a bit of a mission for you. So my heart goes out to you and hang in there for two more days. And all my love, please, to Pat Farmer. I love the guy. He's just amazing. We got to hang out when we're in the Big Red Run together, which I failed spectacularly, by the way. I had a back injury that walked me out in the middle of that race. But one of the big advantages of that run was actually getting to meet Pat Farmer because he's an absolute legend of the sport. So you two together would be a really powerful combination. I'm really sad that he's not going to go right around Australia because imagine the people that would have come out and enjoyed meeting you two. Dean: Oh, he pulled all the strings. He's very well connected in political circles and the Australian Army is crazy for us. So we had 13 Army personnel and they're setting up a tent city every night, and they're cooking for us. It was amazing but COVID had other plans. Lisa: Oh, bloody COVID. It's wrecking every damn thing. Hey, but it's ultramarathon runner and Pat Farmer who has run from the North Pole to the South Pole, people. Absolute crazy guy. Obstacle? Find a way around it. Obstacle? Find a way around. And that's what you guys are doing, and you have to be flexible. That's a good lesson for this day and age because we're all having to be very, very flexible right now, and adapt to a hell of a lot of change, and being able to cope in different situations. So I bet you guys would just find a way through it and it will be another incredible story at the end of the day. Dean: I think the world needs it. As controversial as the Olympics were, I think it was an amazing thing, and it's so scaled back, right? But still, people are stuck in their house and now, what are they doing? They're watching the Olympics. They're getting energised, and they're thinking about the future so yeah, thank you. It's been a very emotional journey for me to leave a place... Where I live in California, we're over 80% vaccinated. So to leave a place where there was no masks then come here, it's been eye-opening and challenging. Lisa: You should have Pat go to you and run around California. You got it backwards. I have no doubt that you guys will just find a way through, and you'll make it epic, anyway. Say you get given lemons, you make lemonade. Dean: Yeah well, at least we're staying in military barracks, and we're basically running. Every day, we're staying in the same place so logistically, it'll be easier. Lisa: Yeah. Oh my god, you guys just don't stop. I admire you guys so much, and I was saying to you last year, when we're in the Gold Coast, 'I've hit the wall at about 48 but to be honest, I had a pretty hit on, full-on war with my body and....' But you guys just seem to keep going, and going, and going. I had Mum as well so I did have an excuse, guys. But pretty highly, it was a stressful last five years. But you just seem to... Because how old are you now, Dean, if you don't mind sharing? Dean: Yeah. Well, when anyone would ask my age, I would say, 'Are you talking about my chronological age or my biological age?' Lisa: Well, your chronological because biological, you're probably 20 years younger. Because I definitely am. That's my take on it. Dean: Chronologically I'm closer to 60 than 50. Lisa: Exactly. Have you actually ever had your biological age done? Because that's an interesting thing. Dean: Yeah, I had a couple. There's a lot of good ways you can test it, and I've had it done a couple different times. One, I was about I was in my late 30s. And then on another, I was older than my actual chronological age. Lisa: Which one was that? Dean: It was post ultramarathon. So after racing, we spoke about C-reactive protein earlier and inflammation. And that was one of the biomarkers that they used in calculating your biological age. So when I looked at the results, I said, 'Hold it. How did you arrive at that figure?' And they gave me all the markers they looked at, and I said, 'Well, look. This is wildly elevated because just four days ago, I just ran a hundred miles.' Lisa: Exactly. And C-reactive protein, if you've just had a cold, if you've just hit like we were talking about my dad before and sepsis and his C-reactive protein was just through the roof. So that makes sense that they would be out. There's a whole clock, which is the methylation markers, which is a very good one. I've done just one very basic one that came out at 34. I was pretty pleased with that one. At the end of the day, I think if you can keep all your inflammatory markers like your homocysteine and C-reactive protein generally under control, keep your albumin levels high, they are pretty good markers. Albumin is one that is looking at, it's a protein that your liver makes, and that's a very important one. And if you albumin starts to go too low, that's one sign that things aren't going to good. So keep an eye on all those. I love studying all this longevity stuff because I plan to live to 150 at least, and I don't think that that's unrealistic now as long as I don't get run over by a bus or something. With the stuff that's coming online and the technology that's coming, we're going to be able to turn back the clock on some pretty advanced stuff already. Now, my mum's on more than me because obviously, her needs are a bit greater than mine. I can't afford for us to be on all the top stuff. But yeah, I'm very excited. We don't need to age like our grandparents have aged. We're gonna have... And someone like you, Dean, who's lived a good healthy life, apart from pushing the hell out of your body, and I'll talk about that in a sec, but I think you've got the potential to live to 150, especially because you're Greek. You come from stock. Dean: And my mom is from one of the Blue Zones. An island called Ikaria and I've been there and I've met... Ikaria, the island she's from, has the highest concentration of centenarians anywhere on Earth. Lisa: Oh my gosh. So you're going to live to 200 then. Dean: Well, the beautiful thing about these people is that not only are they over 100, they still have a high quality of life. They're still mobile; they're self-sufficient. Mentally and cognitively, they're sharp as a tack. They're active. The one thing that they have that we don't have the luxury of is the complete absence of stress. They don't pay attention to time. Lisa: That's, I think, a crucial point. Stress is a killer in so, so many ways. Dean: Even the fact that we have mortgages, and we have payments, rent, all those sort of things, I think, contribute to obviously, to stress. And fitting in with new society. It's much more of a sense of community in these villages where everyone is part of it. They all take care of each other, so it's a different lifestyle. Lisa: I think, definitely when you're actually living the old way of being out in the sunshine, from the time you get up to the end of the day, you're working outside and on the ground, in the land, hands in the dirt, all of that sort of stuff really... Because I studied lots about circadian rhythms and how our eyes, for example, you see sunshine early in the morning. That resets your circadian rhythms, sets the clock going for the day. Your adenosine starts to build up over the day. You get tired at about 14 to 16 hours later. All of these things that we've... as modern-day humans, we've taken ourselves out of the old way of living and put ourselves into this artificial comfortable environment. But this is upsetting all our ancient DNA, and that's why that's leading to problems. And then, of course, we've got this crazy life with technology, and the stuff we have to do, and work. Just like stress, what it does to the gut, the actual microbiota in the gut, and how much it affects your gut health. And of course, gut health affects everything. Your brain and your gut talk all the time. All these stuff so I think if we can harness the cool stuff of the technology coming, plus go back and start respecting as much as possible our ancient DNA, and then eating our ancestors did as best we can with these depleted soils, and pesticides, and glyphosates, and God knows what's in the environment, but doing the best we can, then we've got a good chance of actually staying around on this planet and still be running ultramarathons or at least marathons when you're a hundred plus. I don't think that that's unrealistic anymore, and that excites me. So I'm always learning on that front. Dean: But I want to be that guy that's running a marathon when you say a hundred. That's my ambition now. Lisa: I'll keep you up on the latest stuff then. What you need to be aware of. Dean: I don't have any... People say, ‘You must have arthritis, or back pain, or knee pain, or joint pain.' I don't have any of those things. I don't know why but I just... I'm so happy. I get up every morning and feel fresh. Lisa: That's absolutely amazing. I think one of the amazing things with you is that... Because I studied genetics, and I looked at my genes. And actually doing really long bouts of exercise with my combination of genetics and my cardiovascular system, especially I've got a very weak glycocalyx, which is the lining of your endothelial cells. Bear with me people. This means that if I do a lot of oxidative damage, which you do, of course, when you're running, that's pretty damaging to my lining of my blood vessel. So I've got to be a little more careful and take a lot of antioxidant support. But having that inflammation means I can now take steps to mitigate that so that I can still do what I love to do. And that's really key. It's hitting stuff off at the pass and there's so much we can do now and that's really, really exciting. But I've gone completely off topic because we should be talking about your book. Dean: No, I think it's very relevant because I think that some people are built to run far and slow and other people are built to run quick and short. Lisa: Yeah. I do and I agree and it's not just about your fast-twitch fibres. It is also about your methylation and your detox pathways, your hormonal pathways, your cardiovascular genes. All of these things do play a role, and that's why there's no one size fits all. And that's why we don't all have to be Dean Karnazes or Pat Farmer. You know what I mean? Not everybody is built for that or should be doing that, and that's okay as well. And working out what is optimal for your health is the key thing. Having role models like you guys is just mind-blowing because it does lift your perception of what the human body is capable of. That leads the way for others, and to follow, and to test out their personal limits. I think that's important too. Dean: Well, I've run over 300 traditional marathons. And you go to the Boston Marathon, you go to these big marquee marathons, the New York City Marathon, and you see people in their 70s and 80s that, compared to their peers, are off the charts. You say, 'Well, that running is gonna be bad for you.' I don't subscribe to that. Lisa: I've done what, 70-odd thousand K's. Not as much as you have. And I don't have any knee pain. I don't have any back pain because I keep my core strong and that's despite having accidents with my back and having no discs. Because I keep myself fit and healthy. I have had some issues with hormones and kidney function because when we... You would have been rhabdomyolysis, no doubt a few times. Dean: Minor, minor, but I have. Yeah. Every ultra runner has, yeah. Lisa: Yeah, so things that. You've got to just keep an eye on and make sure you don't... You look after your kidneys otherwise and do things to mitigate the damage. Because yeah there are certain things that damage. But life damages you. Like living, breathing is damaging. It's causing oxidative stress. So you've got to weigh up the pros and cons, but having an active physical life outdoors, and having adventures, and being curious and excited, and being involved in the world, that's got to be beneficial for you. So when do you actually start with this big adventure with Pat? Dean: It's on the 14th of August, so in about a week. Yep. They finish on the 24th, yeah. Lisa: Oh, I'd like to get you both back on at the end of it to give me a rundown, have a go. That will be cool. Dean, let's just pivot now and let's talk a little bit about your book. Because you brought out some incredible books over the years. You're world-famous. You're a New York Times bestselling author. You've been named by the Times magazine as one of the most hundred influential people of the world. That's just insane. And now, you're brought out Runner's High. What's different about this story? Dean: Well, my first book was Ultramarathon Man, and that was kind of a coming-of-age book. It was about me learning about this crazy universe of ultramarathon and people doing things that I thought was impossible. And Runner's High is five books later and three decades later. How am I still doing it? And how have I changed? How has the sport of ultramarathoning changed? How has the world changed? And that was the book. And it was also a very personal book and that... You're an ultramarathoner, and you know ultramarathon is an island. If you start running these long distances it impacts everyone in your life including your family. Very much for your family. The book, it is not really about running. It's funny. People read it and they say, 'Wow. It's amazing but it's storytelling.' And you and I are both good storytellers, and that was what I just set out to write a book that was true and honest, and it was enjoyable for the reader. And yeah, it's doing really well in New Zealand, actually. Lisa: It must be doing well around the world. And this one is very... It's really real, and genuine, and raw. No holds barred. No barred... What do you call it? No... How do you say that? It's very much a real and it's a love letter to, basically, like you say, to running. And you're actually revisiting the Western States, a race that you've done how many times? 13 times or something? But coming back in your 50s, late 50s to do this again in 2018. It was a bit of a tough road, shall we say. Can you tell us a little bit about that part of the journey and why Western States are so special to you? Dean: Yeah. The Western States 100 mile endurance run is in the Sierra Nevada, California. And it was the first 100-mile trail race, and I first did it back in 1994. So your first is always your best. It's kind of this amazing experience that you have, and you just never forget it. I can recall literally conversations I had in that race in 1994. I can recall what people were wearing. I can recall where I saw my parent. I recall it. It gets impressed upon your mind. So my synapses just absorbed it. So going back here after 13 goes at it and thinking, 'Wow, is this going to be a stale experience? Or what is it going to be like?' And it ended up being quite magical and quite transformative in my career as well as... I learned a lot about my father and my son, and I wrote a lot about that in the book, and watching them crew for me, and how things have changed over time. It wasn't a good race. I don't want to be a spoiler but I think good races don't make good stories. Good races, you pop the champagne, yeah, it's boring. You high five at the finish, you have some champagne, and all this good. When things go to shit, that's an interesting story. Lisa: Yeah, absolutely. I've got three books full of things turning to shit. And I think it's beautiful that you talk about your dad or what a crazy guy he is, and your son coming and how your son was actually... Like you didn't know whether he was up to crewing for you really because he's a young man. He wasn't going to take this seriously because you need your crew to be on form. How do he actually do when he was out there? Dean: Yeah. There's a saying that in school, you get the lesson and you take the test. In parenting, you take the test and then you get the lesson. You're just like, 'Boy I screwed that one up.' You lose track of your kids, especially when they go off to uni. Lisa: Just interrupting the program briefly to let you know that we have a new patron program for the podcast. Now, if you enjoy Pushing the Limits, if you get great value out of it, we would love you to come and join our patron membership program. We've been doing this now for five and a half years and we need your help to keep it on air. It's been a public service free for everybody and we want to keep it that way. But to do that we need like-minded souls who are on this mission with us to help us out. So if you're interested in becoming a patron for Pushing the Limits podcast, then check out everything on patron.lisatamati.com. That's patron.lisatamati.com. We have two patron levels to choose from. You can do it for as little as 7 dollars a month, New Zealand, or 15 dollars a month if you really want to support us. We are grateful if you do. There are so many membership benefits you're going to get if you join us: everything from workbooks for all the podcasts, the strength guide for runners, the power to vote on future episodes, webinars that we're going to be holding, all of my documentaries, and much, much more. So check out all the details: patron.lisatamati.com. And thanks very much for joining us. Dean: As a parent, your kids grew up quicker than you adjust to them growing up, and I always treat them as a guy that needs his diaper change kind of thing even though he's 20 years old now. Nick was just such a dichotomous individual because he complained to me when he came home from uni that his roommates were such slobs. I said, 'How do you like living with three other guys?' He's like, 'It's great. They're my best friends, but they're such slobs.' Every every time I walked past his room, I'd look in his room, and it was a Tasmanian devil had gone through it. ‘Your room is such a mess.' When he volunteered the crew for me at Western States, claiming he knew how to do it, even though the last time he'd done it, he was nine years old, and he didn't do anything. At this time, he was actually driving a vehicle. He was the most important support I had during this kind of foot race. And I just thought that it was gonna be a horrible experience. That he'd be irresponsible, he wouldn't show up, and this, and that. At least it was just the opposite. He was the most responsible, so much more responsible than my dad. So much more capable. My dad's been doing this for 30 years, and my son who's never done it was so much better than my dad. He showed me a new side of him that I'd never seen. Lisa: That's him growing up, I suppose? Dean: Yeah. I think every parent that's got a kid is kind of nodding their head as they're hearing this because they can relate. Lisa: Yeah. Yeah. Yeah. And I think kids, sometimes when they can be a kid, they'll be a kid. They'll be the irresponsible... But when you actually put them on the spot and expect something from them, sometimes, they come to the party if you're lucky, and actually step up to the line, and actually do a good job, and obviously, Nicholas did that. Dean: Yeah. I think it's more the burden of the parent to accept and to realise that this little baby is self-sufficient and capable. Let go of the fact that they once were so dependent on you. They're not anymore. They have their own life, and they can navigate their way through the world. Lisa: It must be pretty hard to let go. What do you think it's been like for them having such a famous, crazy, extreme athlete dad? Was it hard for both of them? Because I can imagine you were away a lot. You're doing dangerous, crazy, amazing things. Everybody knows you. You're extremely well known when you go anywhere. How did that affect the family in general? Dean: It's funny. My kids have never known me as anything different. They've always known me as this ultramarathoner, and it's always been a family affair for me. My kids, they've been to Australia, they've been to Europe multiple times, South America, all over North America. I have taken them with me. I once ran 50 marathons in all of the 50 US states in 50 days, and they were along. Yeah. How many kids... My son was nine, my daughter was 11. How many kids ever, how many people ever get to see all of the states of America, let alone when you're that age? So I think that they just accept me for what I am. Sometimes I get the fan thing where people come up to me like at a restaurant. Like, 'Oh, can you sign this or that?' And it's always good people. The people that come up to me in an airport and say, 'Hey, I really admire you. Can we do a selfie?' They're decent people. Like I want to go have a glass of wine with this guy or this lady. It's not like I'm a rock star or movie star where I have all the crazy people chasing around. The people who chase me around are my peers. People I really admire myself. Lisa: Or other runners. You know what? Something I've always admired about you, too, was that you always gave every single person time of day despite... And when we did that speaking gig together last year on the Gold Coast, I was really nervous, to be honest, because I was like, 'I'm on the stage with someone who is a superstar, and I'm little me.' Right? I'm sort of like, 'How the hell am I on stage with you? Because no one's gonna be interested in what the hell I've got to say when you're standing next to...' It's like some superstar, and you're standing on the stage with them, and you've got to do... It was quite difficult in a way because everybody wanted to... The line for your books was just two hours long. The line from mine was two people long. Dean: You carried yourself beautifully. I thought together, we were a great pair. We complemented each other. Lisa: You are a gentleman. You would always straight to me and make sure that I was included, which was fantastic. I saw you. Like you take the time for every single person. You are present with everybody, and that's a really hard thing to do. It's not so hard in a book signing, but it's bloody hard in the middle of a hundred-miler or a hundred K-er or when you were half-dead, dragging yourself into a checkpoint, and somebody wants a signature from you or a selfie, and you're trying to just get your stuff together. I found that difficult on my level of stuff. Because when I enter in New Zealand, I found that really difficult. I'd have people coming out on the road with me all the way through. And in that preparation, I thought that would be cool. In the reality of the day-to-day grind, did you know when you're... Because I was running up to 70K's a day. I was in a world of pain and hurt most of the time, and just struggling to keep going, and very, very breakable, you feel like. And then, you'd have people coming out and now it's been maybe 2, 3, 4 or 5K's with you, and they're full of beans, and they want you to be full of beans and full of energy, and give them the greatest advice in their 5K's when you're half dead. I found that really, really hard because I'm actually, believe it or not, quite introverted and when I'm running, I go in. How do you deal with it? How do you deal with that without being... Because you don't want to be rude. You don't want to be disrespectful to anybody, God forbid. But there were times on that run when I just literally had to say to my crew, 'I can't cope right now. I'm in a world of pain. I need some space.' And they have to sort of politely say, 'Sorry, she's not in a good space.' How do you deal with that? Dean: Well, it's amazing that we're having this conversation because there are not a lot of people that can relate intimately to what you just said. Because most people will never be in that position but what.. I experienced exactly you've experienced. When running 50 marathons in 50 days or running, I ran across America as well. When you're in a world of hurt, you've got this protective shell on, and you don't want to be social, and then I'd have groups of college kids show up with my book. Like 'Oh my god. Karnazes, you're such a great influence, and we love your book.' And 'Let's order a pizza.' I just feel like I just want to crawl into a mummy bag and hide and you just got to turn it on. Lisa: You've got to step up fine. Dean: Yeah, they're so happy to see you, and they want to see you on. They don't want to see you like this groveler just dying. They want to see you strong and engaging, and it's really tough sometimes. Yeah. It's definitely really tough sometimes. Lisa: Yeah, and that's why I admire that you managed to do that most of the time. You turn it on no matter in what shape you were. If I were to pull it out whereas, to be honest, a couple of times, I just couldn't. I'm just like, 'I'm done guys.' Remember on the run through New Zealand that one time? This was not with fans. I was running for CanTeen, the kids with cancer. I was in an immeasurable world of hurt one night after running for, God knows how long I've been out there, 1200 K's or something at the stage. I had a 13-year-old boy was sent into my room to give me a pep talk. He was dying of cancer or had cancer, and he was here to give me a pep talk because I was crying. I wasn't able to get up and run the next day. And he came in and told me how much it meant to him, and to his peers, and what it meant to him that I was undertaking this journey. That was a real lesson. Like, 'Oh, get over yourself. You're not dying, okay? You're not a 13 year old with cancer. You just have to run another 70 K's tomorrow. So what?' That's a good perspective. I did get up the next morning and go again and that was like, 'Here, come on.' Some funny but really touching moments. You are human and it's very easy when you go to a speaking engagement or whatever to be what you meant to be, a professional. But it's bloody hard when the chips are down and you're in the middle of a race to do that. So I really always did admire that about you. What I also admired was that it didn't matter whether you came first or last in a race. With the Western States, it was a struggle. You never shied away from the fact that today might not have been your day, and you're having a bad day, and you weren't embarrassed about that. I've had races with Pat Farmers, a classic one in the middle of the Big Red Run where I was just falling to pieces. I was going through some personal trauma at the time, and my back went out. Yeah, I was just at a bad place. And I was embarrassed because I failed at a race at that stage. I was in that mindset. Now, I look back and go 'Give yourself a break.' How do you cope with that? How do you... Like when you don't do what the fans expect you to do on that day? Dean: To me, it's your ego. Yeah, it is such an ego thing. And let's be honest, when you're a public figure, your failures are public. You don't fail in silence. You just kind of DNF and walk away and live the race another day. You DNF and people are taking pictures of you, and it's on the internet. I always got crowded. But in the end, I just... What can you do other than just do your best? You're human. All of us can only just do our best. So my commitment now is like, ‘When I stand on the starting line, I'm going to give it my all. I'm not going to leave anything on this course. I'm just going to be the best that Dean can be. I'm going to try my hardest and the only way I'm going to fail is if I don't try my hardest and don't give it my all.' And when you go with that mindset, no matter what happens, you're doing yourself a service. Lisa: Yeah, and you're a winner. This is such a powerful message, I think, for young people listening because often, we don't even try because we don't want to risk embarrassing ourselves, and risk failure, and risk looking like an idiot. And what you're saying is just forget your ego, set that to the side, and go, 'I'm going to give it all today, and if it isn't enough, it isn't enough and that's fine. I'll learn something out of it. And it's a journey that I'm on. And I'm going to be the best I can be today.' That's such a powerful story of perspective, and resilience, and leaving the ego at the door. I did struggle with that when I was younger because I had some pretty spectacular failures, and they really hurt. They really hurt where you take a long time to sort of go, 'Do I want to do that again in the public eye?' So to speak. And you've just always just been 'If it was a good day, it was a good day, and on to the next one if it was a bad day.' Dean: Yeah, I think bold failures build character. I have to be honest. Success builds character, but so does failure and in a more profound way. I lean into every emotion that I have. Either success or failure, sorrow or regret. All those things that happen when you have a bad race or a bad day. I want that full emotional range. It just makes you a better human, I think. Not to shy away from those deep lows where you're just crushed. I think that people that try to avoid that are really missing out. Yeah, yeah, it's painful and it hurts but it builds your character in a profound way. Lisa: Wow. That is so deep, actually. Because we're often taught push down your emotions, and keep them in a box, and be a professional, and keep going, and keep calm and carry on type thing. And it has its place as far as when you're in the middle of a race, you've got to keep your shit together, and compartmentalise stuff, and be able to function. But I think it's also very important to experience the pain, the grief, the pain, or whatever you're going through, and the happiness. It's another thing. I would get to the end of a race and it didn't matter how well I'd done, and what I've just achieved, and how difficult it was. I remember doing one in the Himalayas and a friend coming up to me afterwards and it was 220K race, extreme altitude, hell of a journey to get there, all sorts of obstacles. I get to the finish line and he's just like, 'Wow, you're amazing. It's incredible. I can't believe what you just did. If I hadn't seen it, I wouldn't have believed it.' And I just went, 'Oh no. Someone else was faster, and there's a longer race.' You know what I mean? And I didn't integrate it. And he just went, 'Oh, for crying out loud. Can't you just take this one to the bank and actually bank it as being a success and a huge win?' And I really took that to heart. And now, I pat myself on the back when I do even a little thing good because it reinforces that neural pathway in my brain that tells me, 'This was great because I just got a little reward' rather than, 'You're never good enough.' Because that was what I was telling myself before. No matter what I did, it wasn't enough. And now, flip that script around to go, 'Hey, you managed to do your shoelaces and get to the end of the road today. Well, done.' And it's the thought of it. Dean: It is, completely. My son said something to me that was along that same vein during the Western States. I said, ‘Nicholas…' This is maybe a mile 60 or 70 of a hundred-mile run. I said, 'My race is crap. I'm not having a good race.' And he looked at me, said, 'Dad, you're running a hundred miles. To most people, that's enough.' And I put it in perspective. That although I'm with all these super elite athletes, you're not doing that... To most people that hear about anyone running a hundred miles, they don't care if you came in first or last. A hundred miles? They don't care if my time was 15 hours or 50 hours. They're just so inspired. Yeah, blown away by it. Yeah. Lisa: Exactly, And I think that puts it because when we hang out... Because you are the sum total of the people that you hang out with, the top five, as the saying goes. And that can have negative connotations as well as positive. It can be the fact that you think if you're hanging out with the five top guys in the world, then you are going to be not looking too good. But if you're hanging out with just the average person, and you're doing something this long and this incredible, for most people, that's just like, 'Huh? Humans can do that?' I did a speaking engagement yesterday in Auckland and the people were like, 'But that's humanly impossible.' I go, 'It actually isn't, and there's actually thousands of us that do the stuff.' And then, they're like, 'What? I don't get it.' Dean: That was it. That was the same reaction I had when I heard about someone running a hundred mile like that. They're, 'Oh, there's trickery.' I thought there's trickery. I thought there's hotels, or just campgrounds, or something. The guy said, 'The gun goes off and you just run, and you stop when you cross the finish line.' I couldn't wrap my head around it. Lisa: Until you did it. Dean: Until you did it. Exactly, yeah. Lisa: And you built yourself up to it, and this is the thing. It's a combination of so much and it's that journey isn't it? So I think what we're talking about is it being this incredible life journey that you go on within an ultramarathon and within the training of our ultramarathon. It's like living an entire life in short. You're going through the highs, and the lows, and everything in between. And it's long, and it's hard, and it's awesome, and it's amazing, and you meet incredible people. It's everything that you go through in life but just on an intensive timescale, I feel like. And it's just a beautiful experience to go through, especially with the value of hindsight. Sometimes, in the middle of it, mile 70 of a hundred-mile race, it's not looking too flash. Dean: Well, but I mean, to that point, when we reflect back on moments that we remember, at least me, it's not the victories. It's not the crossing the finish line first to me. It's always that time where I thought, 'I'm done. This is it. I can't get out of this chair. I'm trashed.' And somehow getting through that really, really tough moment and carrying on. That's what sticks with you. It's pretty weird, at least with me. Those are the moments that reflect back on my career. It's those horrible moments that I somehow persisted. Lisa: When you look back, you're proud of yourself and you know that when... One of the biggest values, and I've seen this with my story with Mum and, unfortunately, recently with my dad, is that when the shit hits the fan, like it did in those two situations, I knew that I could step up to do everything within my power and that I was a fighter. I knew that I was a fighter, and then I knew that I would fight to the bitter end, whatever the outcome was. And that's a really good thing to know about yourself. Because you need to know that when things are down, what character do you have? Who are you when all the niceties of our world have gone? What are you capable of? And you learn to be able to function when everyone else is gone. And that's a really powerful lesson that ultramarathoning teaches you, I think, in decades of the sort of hard work. And that's why athletes, I think... When you're employing athletes or you going into business with other athletes, you're more likely to have someone who's willing to fight through the tough times than if you just get someone who hasn't ever experienced any sort of discomfort in their life. Then they're not liable to be able to push through and be as resilient. I think that's what I'm trying to say. Dean: I agree with you completely. And I often wonder if people have those character, those values, and that's what draws them to ultra running or if ultrarunning instils those values. I remember coming home from a run one time, and my neighbour was fetching up the morning paper. He saw me running back to my house and I'd, I don't know, I'd run 30 or 40 kilometres, and he said to me, 'Doesn't running hurt?' And I said to him, 'It doesn't if you're doing it right.' And he looked at me, 'I do everything to avoid difficult things.' And I'm like, ‘And I embrace it.' It's just a different mindset. Lisa: And if you have the mindset of wanting to always avoid all sorts of pain in life, then you're not going to experience very much. And when you're in a tough situation, you won't be able to cope because you won't have experienced any sort of pain. So the more that you had to struggle, the more strength you develop from that. The old proverb: 'Strength comes from struggle' is valid in all walks of life. So unfortunately, this is the way the world is set up. If you seek comfort all the time, you're actually going to be in deeper shit somewhere along the way and not able to help yourself because you haven't learned to fight, and you haven't learned to push through and to deal with a certain level of discomfort and a certain level of pain. And I think that's a really, really valuable thing to do. Every day, I try to experience some sort of discomfort or pain: whether it's cold, whether it's pushing myself mentally, intellectually, whether it's pushing myself physically, doing some intense extreme exercise, or whatever the case may be. Every day, I try to do something that it scares the shit out of me or pushes me in some way because then, I know that I haven't gone backwards that day. I've probably learned something, and gone forward, and I've strengthened my body and my mind in some sort of way, shape, or form. Dean: Yeah, but I think you're an exception. I think most people just try to take the path of least resistance and avoid difficult things and avoid pain. I think we've built our world around comfort: having every comfort available and removing as much discomfort and pain as we can. And I think, in a way, we're so comfortable, we're miserable. Lisa: Exactly. That's exactly the problem. Because by actually experiencing a little bit of pain, by doing your push-ups, going for your run, doing your pull-ups, whatever the case is, being outside and digging the garden and doing stuff that is a bit unpleasant, it actually makes your body stronger, and it makes you mentally stronger. If we all sit on the couch and watch Netflix all day every day and eat chips, what's going to happen to us? We're going to destroy our health. We're going to just be so... And this is... I think I'm scared for the younger generation, that they haven't actually... We grew up. We're roughly the same age. You're a couple years older. I grew up in the 70's where we were outside, doing something all day, every day. We came in at night time for a feed and went to bed. That was our childhood, and that was just a beautiful way to grow up. We were cold. We were hungry. We were tired. We were happy. Dean: We were playing, right? We were exercising. I remember riding my bike just everywhere. I never thought of it as exercise. It was playing. Kids don't play that way anymore, unfortunately. Lisa: It's a scary thing for them because we need to teach them. Because again, it goes back to sort of respecting our ancient DNA and that's what I think... That's another thing that ultramarathoning does, or even trekking, or adventuring in any sort of way, shape, or form. It's that we've come from stock that used to have to build their own houses, cut down their own trees, chase animals, whatever the case was, just to survive. And then, we now have it all laid on for us. We're in lovely houses. We've got light all day or night. We've got food every street corner. And our ancient DNA isn't just set up for that. This is where all the problems come. We could go on a complete rant, which I often do on this podcast. But coming back to your story in your Runner's High, what do you think now looking back at this incredibly long and prolific career and this incredible journey that you've been on so far, and I do think that you still got miles and miles to go. What are some of the biggest lessons that you've learned along the way on the thirty-odd year journey that you've been? What are the biggest takeaways from ultramarathon running? Dean: I think that it's the little moments that are the most priceless. It's not the moments where... I write about meeting with First Lady Michelle Obama. Yeah, that was great. It was amazing, and incredible, and everything else, but it's the little moments of having a moment with a crew member or your family that you just you reflect on and laugh about. So it's those things to me that are most priceless. The other thing with ultramarathoning that I've certainly learned is that it's a journey. To me, it's a passion and it's something I've committed my life to. And staying true to the person you are, there's value in that. Even though it's just running, Lisa. It's nothing hugely intellectual. I'm not winning Nobel prizes. I'm just a runner, but that's who I am and I'm staying true to that. I'm going to do that to the grave. And I think in that, there's a simplicity and I think there's some magic in that. Lisa: Oh, absolutely. You know what you're born to do. You say it's only running but actually, you're a teacher; you're an author; you're a person who empowers others. You're doing all of that in the framework of running. So you do a heck of a lot more than just running for me. You've influenced an entire generation worldwide. I hope you know. Without you, ultramarathon running would not be where it is today. So I think you know a little bit more than just running yourself. This is the power of books, and this is the power of storytelling. And it's the power of having such a unique character that is so charismatic and draws people in. And those are all the things that you've managed to take. You could have just been a silent runner who just did his thing and went away again, but you've chosen to share your journey with the world. And that's just gold because that just gives people an insight into what they can do. It's all about... when I read your books, I'm getting something for me. And everybody who's reading those books, that's actually, 'Yes, we talk. We're hearing Dean's story.' But we're actually going, 'Huh. Maybe I could do that. Maybe I could try that. Oh, yeah I've experienced that.' This is the conversation that are going on in people's heads when they read those stories, and that's why they have such an intimate connection with you. And why, even though it's weird when people come up and ask you for an autograph or any of that, they feel like they know you, and they do know you. Dean: I've got a message from a guy. Yeah, I know. Every time I think, 'Wow, this is really laborious, writing these books. And maybe it's my last book.' I got a message from a guy a couple days ago and he said, 'I was planning on reading a couple chapters of your new book before I went to bed.' And he said five hours later, 'I finished the last page.' And then, he said, 'And then I got up. I just had to go running.' Wow. Then the book worked if it motivated him to read the whole thing in one sitting and get up and go running, then it's worthwhile. Lisa: Absolutely. And you know when you read, I read books ferociously, and the list is long. I'm usually reading about 10 books at a time. And when I'm reading, I am distilling the world's top people and their entire experience, I get to absorb within the space of 10, 15 hours of reading their book. That's a good return on investment. If I want to download someone's experience, or knowledge, or whatever the case is, then reading books is just such a powerful way to do it and listening to podcasts as well. Because that's another way that you can do it without having to... You can be out and about, driving, or running, or whatever and absorbing some new information. And I think we're just so lucky to have access to all of this. It's just incredible. Dean: It is and it's a pity if you don't take advantage of that because you're so wise and educated. That conversation we had before the podcast, it's amazing how... It's amazing. Your knowledge base and how you developed your knowledge base. Well, you've absorbed the best of the best and what they're thinking and the research they've done. Lisa: Exactly. All you're doing is you're absorbing it from the best scientists, the best doctors, the best athletes, the best executives, the best business people, and then, you get to share it, teach it. This is the other thing. If I learn something in the morning, I'm teaching it in the afternoon. Usually it's to my poor husband or my mother. I'm teaching it and then, I often build into my programs, or it comes out in my webinars, or whatever. And you're basically just regurgitating stuff that you've learned, but it's powerful when you put it into the perspective of your experience and you change it. You learn it, you teach it. You learn it, you teach it. And that's a such a cool way to share, and get that information out there into the world, and actually help the world on your little corner of the earth and what you're doing. And that's what I love to do and that's the power of what your books are all about. So yeah, I commiserate with you. Getting a book out is a bloody long, hard journey. People don't realise how hard it is to write a book. Give me a bloody hundred miler any day over writing a book. In fact, give me ten hundred milers over any day because it's such a long process, isn't it? Dean: Well, I do a lot of my writing while I'm running actually. So I dictate into my phone now. Because we have some of our clearest thoughts while we're running. Before, I used to think, 'God, why didn't I write that down? How did that go again?' Now, I just dictate as I'm running and then come home, put in an earbud, and just type up my notes. Lisa: I haven't done variations of that. I do end up stopping on my runs and just writing a quick note. I haven't actually dictated. I have to start adapting that because maybe that'll make it easy because you're damn right. When I'm actually at the computer, there's distractions. There's a hundred windows open; there's notifications coming all the time, and I really find it hard to sit down and write. It is sometimes best if you could just dictate into something, so I'll have to give that a crack next time. Dean: I think motion stirs emotion. Lisa: Yeah, it does and it clears the mind. That's one thing I miss now that I'm not doing the ultras, personally, at the moment. It's that singularity of purpose. That cleanness the mind had before of this one goal. And I'm watching my husband's preparing for a hundred miler in November. And just watching everything in his whole day, and he has the luxury of doing this because we haven't got kids and stuff, but everything in his whole day is centred around his training and getting to that hundr

Dr. Chris Shade, PhD, founder, and CEO of Quicksilver Scientific, is in the studio today for an in-depth exploration on all things immunity, metabolism, and detoxification.  Dr. Shade is a world-renowned brainbox on mercury, environmental toxicities, neuroinflammation, immune dysregulation, and human detoxification. Imagine your biology class on steroids, and you're somewhere close to this man's capacity to educate the complexities of the body's internal relationship to the external landscape.  Aside from sharing copious amounts of wisdom, he also formulated Quicksilver Scientific, an out-of-this-world range of advanced liposomal supplements that support vital health functions. I turned to their protocol when detoxing my body from metals, and their 30-day-detox was a lifeline during my exodus from California to Texas.  If you're looking to upgrade your supplement cabinet, head to quicksilverscientific.com and use code “STOREY10” for 10% off sitewide.  10:43 — Inside The 30-Day Reset Maintaining ketosis while eating what you want Detoxification and metabolism and why both are important NAD building  Understanding the nanoparticle delivery of mTOR blockers.  What causes a leaky liver Why fasting is healing    31:44 — Cellular Health How cells communicate with the nucleus  Inside the extracellular matrix Treating mitochondria as membrane How consciousness affects biology  Adrenal and mitochondria support  Advantages of deuterium depleted water   How geography affects tap water quality    57:12 — What's Trending in Health & Wellness  How losing taste and smell  is connected to zinc Metabolic health as a key part of immune health Why people who intermittent fast deal with virus better   01:19:04 — The Gut & the Immune System  What is a leaky gut Controlling your microbiome  Why water fasting will cure your gut issues Detoxing from glyphosate  How Astaxanthin makes you beautiful  Bowel cleansing to clean your GI    01:42:44 — Heavy Metals 101 Common sources of mercury and why it's bad Metal exposure through food  Toxic cookware  The ultimate mold detox  How to prepare your body for conceiving  NAD for resistance to EMF More about this episode. Watch on YouTube   Connect with Luke on social media to learn how to take your lifestyle to the next level, plus catch exclusive live interviews & events: INSTAGRAM - @lukestorey // instagram.com/lukestorey/ FACEBOOK - facebook.com/MrLukeStorey/ TWITTER - @MrLukeStorey // twitter.com/MRLUKESTOREY YOUTUBE - youtube.com/c/LukeStorey THIS SHOW IS BROUGHT TO YOU BY: PaleoValley. The ultimate on-the-road snack you can trust. These beef sticks are 100% grass-fed, grass-finished, and sourced from small, domestic farms in the U.S. They use real, organic spices to flavor beef sticks vs conventional spices sprayed with pesticides or "natural flavors" often made from GMO corn. They also ferment their beef sticks which creates natural occurring probiotics which are great for gut health. Try them for yourself! Head to paleovalley.com and use the code “Luke” for 15% off.    AND...   CACAO BLISS. Back in the day, I used to have to take about 50 ingredients to make an elixir or a smoothie. 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Nad slovami sv. Ignáca Brjančaninova - Pole 1 - s. 46-49. - Filokalia Live - pravidelné online stretnutia prostredníctvom ZOOM. Zámerom je spoznávanie a osvojovanie umenia duchovného života štúdiom učenia svätých otcov. Pondelkové stretnutia sú venované úvodu do duchovného života podľa manuálu sv. Ignáca Brjančaninova - Pole. Kto by mal záujem o zakúpenie tejto publikácie, nájde ju v ponuke Filokalie, jej vlastnenie však nie je pro toto štúdium nevyhnutné. Štvrtkové stretnutia sú venované uvažovaniu nad dielom Evergetinos. Ide o rozsiahlu zbierku výrokov a krátkych príbehov zo života púštnych otcov, ktorá bola zostavená mníchom Pavlom v 11. storočí. Každá kapitola dáva dôkladné vysvetlenie predstavenej témy a postupne čitateľa sprevádza od položenia základných kameňov duchovného život až po jeho výšiny. Stretnutia sa konajú každý pondelok a štvrtok o 20.00 hod. V prípade záujmu sa môžete zaregistrovať a e-mailom Vám bude zaslaný Zoom link pre vstup na stretnutie.  

How do you handle stressful situations? Everyone's built a little different — some people can take their hits on the chin and come out smiling. But not everyone can take those hits. The pandemic has taken its mental toll on so many people. Others might still be struggling with past traumas and dealing with anxiety. Their situation keeps them in a state of constant worry and hypervigilance. That state of mind doesn't only harm their mental and emotional health — it can make them sick and more prone to physical diseases. More than ever, it's time to begin mental healing from past traumas, so we can better cope with our daily stresses.  Dr Don Wood joins us again in this episode to talk about the TIPP program and how it facilitates mental healing. He explains how our minds are affected by traumas and how these can affect our health and performance. If we want to become more relaxed, we need to learn how to go into the alpha brainwave state. Since mental healing is not an immediate process, Dr Don also shares some coping strategies we can use in our daily lives.  If you want to know more about how neuroscience can help you achieve mental healing, then this episode is for you.    Here are three reasons why you should listen to the full episode: Learn how trauma can put you in a constant state of survival and affect your performance and daily life.  Understand that it's not your fault. Achieving mental healing will require you to learn how to go into an alpha brainwave state.  Discover healthy habits that will keep you from entering survival mode.   Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron!  A new program, BOOSTCAMP, is coming this September at Peak Wellness! Listen to other Pushing the Limits episodes:  #183: Sirtuin and NAD Supplements for Longevity with Dr Elena Seranova #189: Understanding Autophagy and Increasing Your Longevity with Dr Elena Seranova  #199: How Unresolved Trauma Prevents You from Having a Healthy Life With Dr Don Wood Check out Dr Don Wood's books:  Emotional Concussions: Understanding How Our Nervous System is Affected By Events and Experiences Throughout Our Life You Must Be Out Of Your Mind: We All Need A Reboot   Connect with Dr Don Wood: Inspired Performance Institute I Facebook I LinkedIn     Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/.   Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, Run Longer  Without Burnout & Injuries Have you struggled to fit in training in your busy life? Maybe you don't know where to start, or perhaps you have done a few races but keep having motivation or injury troubles? Do you want to beat last year's time or finish at the front of the pack? Want to run your first 5-km or run a 100-miler? ​​Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle?  Go to www.runninghotcoaching.com for our online run training coaching.   Health Optimisation and Life Coaching If you are struggling with a health issue and need people who look outside the square and are connected to some of the greatest science and health minds in the world, then reach out to us at support@lisatamati.com, we can jump on a call to see if we are a good fit for you. If you have a big challenge ahead, are dealing with adversity, or want to take your performance to the next level and learn how to increase your mental toughness, emotional resilience, foundational health, and more, then contact us at support@lisatamati.com.   Order My Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Still, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. 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Manufactured in an ISO9001 certified facility Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health   My  ‘Fierce' Sports Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection.   Episode Highlights [06:05] The Pandemic-Induced Mental Health Crisis The pandemic forced many people into a state of freeze mode, not the typical fight or flight response.  As people get out of freeze mode, there will be a rise in mental health issues.  Teenagers are robbed of the opportunity to develop social and communication skills during this time.  [08:24] How Dr Don Wood Started Studying Traumas Dr Don's wife grew up in a household with an angry father who instilled fear. He used to think that she would be less anxious when they started to live together, but she struggled with mental healing.  She had an inherent belief that misfortune always follows good things. Her traumas and fears also led to a lot of health issues.  She also was hyper-vigilant, which she used as a protective mechanism. However, this prevented her from being relaxed and happy. A person's environment can dictate whether they go into this hyper-vigilant state, but genetics can also play a factor.  [15:42] How Trauma Affects the Brain Trauma is caused by a dysregulation of the subconscious. If your brain is in survival mode, it will access data from the past and create physiological responses to them. These emotions demand action, even when it is no longer possible or necessary. This dysregulation prevents you from living in the present and initiating mental healing.  In this state, people can be triggered constantly, which interferes with their day-to-day life.  [21:07] The Role of the Subconscious Your conscious mind only takes up around 5%, while the subconscious takes up 95%. Your subconscious mind cannot tell the difference between real and imagined.  In survival mode, people will keep replaying the past and think about different scenarios and decisions.  You're left stuck because the subconscious mind only lives in the now. It does not have a concept of time.  This process is the brain trying to protect you. [25:04] What Happens When You're Always in Survival Mode Being in survival mode will take a physical toll since it's constantly activating the nervous system, increasing cortisol and adrenaline. When you're in this state, your body and mind cannot work on maintenance and recovery. It is more focused on escaping or fixing perceived threats. Over time, this will affect your immune system and make you sick.  To truly achieve mental healing, you need to get to the root cause of your problems.  However, you also have to develop coping strategies to manage your day-to-day activities.  [30:18] Changing Your Brainwave State Traumatic events are usually stored in a beta brainwave state. Changing your response to traumatic events starts with going into an alpha brainwave state.  The beta state is usually from 15 - 30 hertz, while the alpha is lower at 7 - 14 hertz. Anything below that is the delta state, usually when you're in deep meditation or sleep. People who have trouble sleeping are usually in that beta state, which keeps processing information.  It's only in the delta state that your mind and body start the maintenance phase. This phase helps not only with mental healing but also physical recovery.  Learn more about Lisa and Dr Don's personal experiences with these brainwave states in the full episode!  [34:30] Mental Healing and Physical Recovery Starts with the Brain Recovery is about genetics and the environment. In sleep, your mind will always want to deal with the threats first. It can only get to the delta state once it finishes processing these dangers. Your risk for developing sickness and depression rises if your brain can't do maintenance. Living in the beta state will make it difficult to focus.  [41:40] It's Not Your Fault If you have a lot of trauma, you are predisposed to respond in a certain way. It's not your fault.  There's nothing wrong with your mind; you just experienced different things from others.  Dr Don likened this situation to two phones having a different number of applications running.  Predictably, the device that runs more applications will have its battery drained faster.  [44:05] Change How You Respond Working on traumas requires changing the associative and repetitive memory, which repeats responses to threats. You cannot change a pattern and get mental healing immediately—it will take time.  That's the reason why Dr Don's program has a 30-day recovery phase dedicated to changing your response pattern.  Patterns form because the subconscious mind sees them as a beneficial way of coping with traumas.  This function of your subconscious is how addictions form.  [47:04] Why We Can Be Irrational The subconscious lives only in the present. It does not see the future nor the past.  It will want to take actions that will stop the pain, even if the actions are not rational.  At its core, addiction is all about trying to stop the pain or other traumatic experiences.  Survival mode always overrides reason and logic because its priority is to protect you. [50:57] What to Do When You're in Survival State In this survival state, we're prone to movement or shutting down completely.  The brain can stop calling for emotions to protect you, and this is how depression develops.  When in a depressed state, start moving to initiate mental healing. Exercise helps burn through cortisol and adrenaline.  Once your mind realises there's no action required for the perceived threats, the depression will lift.   [53:24] Simple Actions Can Help There's nothing wrong with you.  Don't just treat the symptom; go straight to the issue.  Don't blame genetics or hormonal imbalances for finding it hard to get mental healing. Find out why.  Also, seek things that will balance out your hormones. These can be as simple as walking in nature, taking a break, and self-care.  [56:04] How to Find a Calming Symbol Find a symbol that will help you go back into the alpha brainwave state.  Lisa shares that her symbol is the sunset or sunrise, and this helps her calm down. Meanwhile, Dr Don's are his home and the hawk.  Having a symbol communicates to all parts of your brain that you're safe.  [59:58] The Power of Breathing  Stress may lead to irregular breathing patterns and increase your cortisol levels and blood sugar. Breathing exercises, like box breathing, can also help you calm down because the brain will take higher oxygen levels as a state of safety.  If you're running out of oxygen, your brain will think you're still in danger.  Make sure that you're breathing well. It's also better to do nasal breathing.    7 Powerful Quotes ‘The purpose of an emotion is a call for an action. So the purpose of fear is to run.' ‘People who have a lot of trauma have trouble sleeping. Because not only is their mind processing what it experienced during the day, it's also taking some of those old files saying “Well, okay, let's fix that now. Right. Let's get that.”' ‘I was getting maximum restorative sleep. So an injury that I would have that could heal in two or three days, my teammates would two or three weeks. Because they were living in these, which I didn't know, a lot of my friends were dealing with trauma: physical, emotional, sexual abuse.' ‘There's nothing wrong with anybody's mind. Everybody's mind is fine except you are experiencing something different than I experienced so your mind kept responding to it, and mine didn't have that.' ‘That dysregulation of the nervous system. That's what we want to stop because that is what is going to affect health, enjoyment of life, and everything else.' ‘I talked about addiction as a code. I don't believe it's a disease. Your mind has found a resource to stop pains and your subconscious mind is literal. It doesn't see things as good or bad, or right or wrong.' ‘If there's a survival threat, survival will always override reason and logic because it's designed to protect you.'   About Dr Don Dr Don Wood, PhD, is the CEO of The Inspired Performance Institute. Fueled by his family's experiences, he developed the cutting-edge neuroscience approach, TIPP. The program has produced impressive results and benefited individuals all over the world.  Dr Wood has helped trauma survivors achieve mental healing from the Boston Marathon bombing attack and the Las Vegas shooting. He has also helped highly successful executives and world-class athletes. Marko Cheseto, a double amputee marathon runner, broke the world record after completing TIPP. Meanwhile, Chris Nikic worked with Dr Wood and made world news by becoming the first person with Down Syndrome to finish an Ironman competition. Interested in Dr Don's work? Check out The Inspired Performance Institute. You can also reach him on Facebook and LinkedIn.    Enjoyed This Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can learn steps to mental healing. Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa   Transcript Of Podcast Welcome to Pushing the Limits, the show that helps you reach your full potential with your host Lisa Tamati, brought to you by lisatamati.com.  Lisa Tamati: Hi, everyone and welcome back to Pushing the Limits. Today, I have Dr Don Wood who, you may recognise that name if you listen to the podcast regularly. He was on the show maybe a couple of months ago, and he is the CEO and founder of The Inspired Performance Institute. He's a neuroscience guy, and he knows everything there is to know about dealing with trauma and how to get the mind back on track when you've been through big, horrible life events or some such thing. Now, when we talked last time, he shared with me his methodology, the work that he's done, how he can help people with things like addictions as well and depression, and just dealing with the stresses of life, whether they be small stressors or big stressors.  We got to talking about my situation and the stuff that I've been through in the last few years, which many of you listeners know, has been pretty traumatic. From losing babies, to losing my dad, to mom's journey. So I was very privileged and lucky to have Dr Don Wood actually invite me to do his program with him. We share today my stories, how I went with that, and he explains a little bit more in-depth the neuroscience behind it all and how it all works. So if you're someone who's dealing with stress, anxiety, PTSD, depression, if you want to understand how the brain works and how you can help yourself to deal with these sorts of things, then you must listen to the show. He's an absolutely lovely, wonderful person.  Now, before we get over to the show, I just love you all to do a couple of things for me. If you wouldn't mind doing a rating and review of the show on Apple, iTunes or wherever you listen to this, that would be fantastic. It helps the show get found. We also have a patron program, just a reminder if you want to check that out. Come and join the mission that we're on to bring this wonderful information to reach to people.  Also, we have our BOOSTCAMP program starting on the first of September 2021. If you listen to this later, we will be holding these on a regular basis so make sure you check it out. This is an eight-week live webinar series that my business partner, my best buddy, and longtime coach Neil Wagstaff and I will be running. It's more about upgrading your life and helping you perform better, helping you be your best that you can be, helping you understand your own biology, your own neuroscience, how your brain works, how your biology works. Lots of good information that's going to help you upgrade your life, live longer, be happier, reduce stress, and be able to deal with things when life is stressful. God knows we're all dealing with that. So I'd love you to come and check that out. You can go to peakwellness.co.nz/boostcamp.  I also want to remind you to check us out on Instagram. I'm quite active on Instagram. I have a couple of accounts there. We have one for the podcast that we've just started. We need a few more followers please on there. Go to @pushingthelimits for that one on Instagram, and then my main account is @lisatamati, if you want to check that one out. If you are a running fan, check us out on Instagram @runninghotcoaching and we're on Facebook under all of those as well. So @lisatamati, @pushingthelimits, and @runninghotcoaching.  The last thing before we go over to Dr Don Wood, reminder check out, too, our longevity and anti-aging supplement. We've joined forces with Dr Elena Seranova and have NMN which is nicotinamide mononucleotide, and this is really some of that cooler stuff in the anti-aging, and longevity space. If you want to check out the science behind that, we have a couple of podcasts with her. Check those out and also head on over to nmnbio.nz. Right. Over to the show with Dr Don Wood.  Hi, everyone and welcome back to Pushing the Limits. Today, I have a dear, dear friend again who's back on the show as a repeat offender, Dr Don Wood. Dr Don Wood: I didn't know I was a repeat offender. Oh, I'm in trouble. That's great.  Lisa: Repeat offender on the show. Dr Don, for those who don't know, was on the show. Dr Don is a trauma expert and a neuroscientist, and someone who understands how the brain works, and why we struggle with anxiety, and depression, and post-traumatic stress disorder. We did a deep dive last time, didn't we, into the program that you've developed. Since then, everyone, I have been through Dr Don's pro program. He kindly took me through it. Today, I want to unpack a little bit of my experiences on the other side, s the client, so to speak. Talk about what I went through.  Dr Don, so firstly, welcome to the show again. How's it all over in your neck of the woods? Dr Don: Well, it's awesome over here in Florida. COVID is basically non-existent. Oh, yeah. Well, in terms of the way people are treating it, that's for sure. Very few people you see in masks now, everything is pretty much wide open. You can't even get reservations at restaurants. It's unbelievable. The economy is exploding here. There's so much going on. Yeah, I know the rest of the country, a lot of different places are still struggling with whether they're going to put mask mandates back on and all this kind of stuff but Florida seems to be doing very well.  Lisa: Well, I'm very glad to hear that because any bit of good news in this scenario is good because this keeps coming and biting everybody in the bum.  Dr Don: I know. Especially down there. You guys are really experiencing quite severe lockdowns and things, right? Lisa: Yeah and Australia, more so. Australia has gone back into lockdown. I've got cousins in Sydney who are experiencing really hard times in Melbourne and we've stopped the trans-Tasman bubble at the moment. Trans-Tasman was open for business, so to speak, with Australians being able to come to New Zealand without quarantine, but it's been shut down again. So yeah, we're still struggling with it, and the economy is still struggling with it but actually, in our country, we've been very lucky that we've managed to keep it out because they've had such tight controls on the borders. But yes, it's a rocky road for everybody, and it's not over yet, I think. Dr Don: Looks like it's going to continue, and that's creating a lot of stress.  Lisa: Oh, yeah, perfect.  Dr Don: This is what I've said. I think we're coming up to a tsunami of mental health issues because a lot of people have gone into freeze mode as opposed to fight or flight. Some people are in fight or flight. You're hearing about that on airlines: people just losing it, and getting mad, and fighting with flight attendants and passengers, and you see a lot of that. But I think that's obviously not the majority. I think most people are in that mode of just get through this, do what they ask, don't cause any waves, and just get this over with. So that's a freeze mode, and I think when people come out of freeze, you're going to start to see some of these mental health issues.  Lisa: Yes, I totally agree and I'm very concerned about the young people. I think that being hit very hard especially in the places that have the hardest lockdowns. If you're going through puberty, or you're going through teenagehood, or even the younger kids, I think, they're going to be affected massively by this because it's going to be a big before and after sort of situation for them.  Dr Don: And just the social. When we were teenagers, social was everything, I suppose. Learning how to communicate, and talk, and get along with other people, and good and bad. There were always struggles in school with learning how to get along with everybody but that is just sort of squashed. It's going to be fascinating to see when they do a study on the real true results of this pandemic. It's going to be a lot different than many people think.  Lisa: Yes, and I think the longer you ignore stuff, is we're going to see it's not just the people are unfortunately dying and being very sick from the actual COVID, but the actual effects on society are going to be big. That's why talking about the topic that we're talking about today, dealing with anxiety, and dealing with stress, and being able to actually fix the problem instead of just managing the problem, which I know you're big on.  So let's dive in there, and let's recap a little bit. Just briefly go back over your story, how you got to here, and what your method sort of entails in a helicopter perspective. Dr Don: Yeah, basically how I developed this was really because of the life that my wife led first and my daughter. My wife grew up in a very traumatic household with a very angry father that created tremendous fear. So everybody was... Just constant tension in that household. When I met her, I just realised how this was so different than my life. My life was in the complete opposite: very nurturing, loving. So I didn't experience that. I thought when she started moving in and we got married at 19, we were very young, that this would all stop for her. Because now, she's living in my world, my environment, and it didn't.  She just kept continuing to feel this fear that something was going to go wrong and nothing is going to go right. She struggled with enjoying things that were going well. I would say to her, 'We've got three beautiful children. We've got a beautiful home. Everything's going pretty good; nothing's perfect. You have your ups and downs, but it's generally a pretty good life.' She couldn't enjoy that because as a child, whenever things were going okay, it would quickly end and it would end, sometimes violently. So the way she was protecting herself is don't get too excited when things are going well because you'll get this huge drop. So that was what she was doing to protect herself. I just had a lady come in here a couple months ago, who very famous athlete is her husband: millionaires, got fame, fortune, everything you want, but she had a lot of health issues because of trauma from her childhood. When I explained that to her, she said, 'That's me. Your wife is me. I should be enjoying this, and I can't get there. I want to. My husband can't understand it.' But that's really what was going on for her too. Lisa: So it's a protective mechanism, isn't it? To basically not get too relaxed and happy because you've got to be hyper-vigilant, and this is something that I've definitely struggled with my entire life. Not because I had a horrible childhood. I had a wonderful childhood but I was super sensitive. So from a genetic perspective, I'm super sensitive. I have a lot of adrenaline that makes me code for, for want of a better description, I'm very emotionally empathetic but it also makes me swung by emotional stimuli very much. So someone in my environment is unhappy, I am unhappy. I'm often anxious and upset. My mum telling me she took me to Bambi. You know the movie Bambi? From Disneyland? She had to take me out of theatre. I was in distraught.  That's basically me. Because Bambi's mother got killed, right? I couldn't handle that as a four-year-old, and I still can't handle things. Things like the news and stuff, I protect myself from that because I take everything on. It's even a problem and in our business service situations because I want to save the world. I very much take on my clients' issues. I'm still learning to shut gates afterwards, so to speak, when you're done working with someone so that you're not constantly... So there's a genetic component to this as well.  Dr Don: Absolutely. So yours was coming from a genetic side but that's very, very common amongst people who have had a traumatic childhood. They're super sensitive.  Lisa: Yes. Hyper-vigilant.  Dr Don: Hyper-vigilant. That was my wife. She was constantly looking for danger. We'd come out of the storage and go: 'Can you believe how rude that clerk was?' 'What do you mean she was rude? How was she rude?' ‘You see the way she answered that question when I asked that, and then the way she stuffed the clothes in the bag?' And I'm like, 'Wow.' I never saw her like that. She was looking for it because that's how she protected herself because she had to recognise when danger was coming. So it was protection, and I hadn't experienced that so that made no sense to me; it made perfect sense to her.  Lisa: Yeah, and if someone was rude to you, you would be just like, 'Well, that's their problem, not my problem, and I'm not taking it on.' Whereas for someone your wife and for me... I did have a dad who was  a real hard, tough man, like old-school tough. We were very much on tenterhooks so when they came home, whether he was in a good mood today or not in a good mood. He was a wonderful, loving father but there was that tension of wanting to please dad. Mum was very calm and stable, but Dad was sort of more volatile and just up and down. It was wonderful and fun and other times, you'd be gauging all of that before he even walked in the door. That just makes you very much hyper-vigilant to everything as well.  Then, you put on, on top of that, the genetic component. You've got things like your serotonin and your adrenaline. So I've got the problem with the adrenaline and a lack of dopamine. So I don't have dopamine receptors that stops me feeling satisfaction and... Well, not stops me but it limits my feeling of, 'Oh, I've done a good job today. I can relax.' Or of reward. And other people have problems, I don't have this one, but with a serotonin gene, which is they have dysregulation of their serotonin and that calm, and that sense of well-being and mood regulation is also up and down. While it's not a predisposition that you'll definitely going to have troubles because you can learn the tools to manage those neurotransmitters and things like nutrition and gut health and all that aspect. Because it's all a piece of that puzzle, but it's really just interesting, and it makes you much more understanding of people's differences.  Why does one person get completely overwhelmed in a very trivial situation versus someone else who could go into war and come back and they're fine? What is it that makes one person? Then you got the whole actual neuroscience circuitry stuff, which I find fascinating, what you do. Can you explain a little bit what goes on? Say let's just pick a traumatic experience: Someone's gone through some big major trauma. What is actually going on in the brain again? Can we explain this a little bit?  Dr Don: Yeah, this is one of the things that... When I did my research, I realised this is what's causing the dysregulation: is your subconscious your survival brain is fully present in the moment all the time. So everything in that part of our brain is operating in the present. which is what is supposed to be, right? They say that that's the key, that success and happiness is live in the present. Well, your survival brain does that. The problem comes in is that only humans store explicit details about events and experiences. So everything you've seen, heard, smelled, and touched in your lifetime has been recorded and stored in this tremendous memory system. Explicit memory.  Animals have procedural memory or associative memory. We have that memory system too. So we have both. They only have procedural, associative. So they learn through repetition, and they learn to associate you with safety and love, but they don't store the details about it. But we store all the details about these events and experiences. So this is where this glitch is coming in. If you've got the survival brain, which is 95% of everything that's going on, operating in the present, accessing data from something that happened 10 years ago because something looks like, sounds like, smells like it again, it's creating a response to something that's not happening. It's looking at old data and creating a physiological response to it, and the purpose of an emotion is a call for an action. So the purpose of fear is to run, to escape a threat. But there's no threat. It's just information about the threat. That disrupts your nervous system and then that creates a cascade of chemical reactions in your body because your mind thinks there's an action required. Lisa: This is at the crux of the whole system really, isn't it? This is this call for action to fix a problem that is in the past that cannot be fixed in the now. So if we can dive a little bit into my story, and I'm quite open on the show. I'm sharing the good, the bad, and the ugly. When I was working with Dr Don, I've been through a very, very traumatic few years really. Lost my dad, first and foremost, last July, which was the biggest trauma of my life. And it was a very difficult process that we went through before he died as well. And there's a lift, as you can imagine, my brain in a state of every night nightmares, fighting for his life, he's dying over, and over, and over, and over again.  Those memories are intruding into my daily life, whereas in anything and at any time, I could be triggered and be in a bawling state in the middle of the car park or the supermarket. Because something's triggered me that Dad liked to to buy or Dad, whatever the case was, and this was becoming... It's now a year after the event but everything was triggering me constantly. Of course, this is draining the life out of you and interfering with your ability to give focus to your business, to your family, to your friends, every other part of your life. I'd also been through the trauma of bringing Mum back from that mess of aneurysm that everyone knows about. The constant vigilance that is associated with bringing someone back and who is that far gone to where she is now, and the constant fear of her slipping backwards, and me missing something, especially in light of what I'd been through with my father. So I'd missed some things, obviously. That's why he ended up in that position and through his own choices as well.  But this load, and then losing a baby as well in the middle, baby Joseph. There was just a hell of a lot to deal with in the last five years. Then, put on top of it, this genetic combination of a hot mess you got sitting before you and you've got a whole lot of trauma to get through. So when we did the process, and I was very, super excited to do this process because it was so intrusive into my life, and I realised that I was slowly killing myself because I wasn't able to stop that process from taking over my life. I could function. I was highly functional. No one would know in a daily setting, but only because I've got enough tools to keep my shit together. so to speak. But behind closed doors, there's a lot of trauma going on.  So can you sort of, just in a high level, we don't want to go into the details. This is a four-hour program that I went through with Dr Don. What was going on there. and what did you actually help me with?  Dr Don: So when you're describing those things that were happening to you, what was actually happening to your mind is it was not okay with any of that. It wanted it to be different, right? So it was trying to get you into a state of action to stop your father from dying: Do it differently. Because it kept reviewing the data. It was almost looking at game tape from a game and saying 'Oh, had we maybe run the play that way, we would have avoided the tackle here.' So what your mind was saying 'Okay, run that way.' Well, you can't run that way. This is game tape. Right? But your mind doesn't see it as game tape. It sees it as real now, so it's run that way. So it keeps calling you into an action.  And especially with your dad because you were thinking about, 'Why didn't I do this?' Or 'Had I just done this, maybe this would have happened.' What your mind was saying is, 'Okay, let's do it. Let's do that.' What you just thought about. But you can't do that. It doesn't exist. It's information about something that happened but your mind sees it as real. That's why Hollywood have made trillions of dollars because they can convince you something on the screen is actually happening. That's why we cry in a movie or that's why we get scared in a movie. Because your mind, your subconscious mind cannot tell the difference between real or imagined. So that's actually happening.  You were just talking about the movie with Bambi, right? When you were little. 'Why is nobody stopping this from happening?' So your mind was not okay with a lot of these things that were happening, and it kept calling you to make a difference. That's what I never understood my wife doing. That before I really researched this, my wife would always be saying, 'Don't you wish this hadn't have happened?' Or 'Don't you wish we hadn't done this?' What I didn't understand at the time, because I used to just get like, 'Okay, whatever.' She'd go, 'Yeah, but wouldn't it have been better?' She wanted to get me into this play with her, this exercise. Lisa: This is going on in her head. Dr Don: Because it's going on in her head, and she's trying to feel better. So she's creating these scenarios that would make her feel like, 'Well, if I had just done that, gosh that would have been nice, thinking about that life.' And her mind seeing that going, 'Oh, that would be nice. Well, let's do that. Yes.' So she was what if-ing her life. And it was something that she did very early as a child because that's how she just experienced something traumatic with her father. In her mind, she'd be going, 'Well, what if I had to just left 10 minutes earlier, and I had have escaped that?' Or 'What if I hadn't done this?' So that's what she was doing. It made no sense to me because I hadn't experienced her life, but that's what she was doing. Her mind was trying to fix something. It's never tried to hurt you. It was never, at any point, trying to make you feel bad. It was trying to protect you. Lisa: Its job is to protect you from danger and it sees everything as you sit in the now so it's happening now. I love that analogy of these... What was it? Two-thirds of the car or something and... Dr Don: So goat and snowflake? Lisa: Goat and snowflake. And they're going off to a meeting and they're late. And what does the goat says to snowflake or the other way around? Dr Don: So snowflake, which is your conscious mind, your logical reasonable part of your mind, there's only 5, says the goat 95%, which is your subconscious mind. Who runs into a traffic jam says, 'Oh, we're going to be late. We should have left 15 minutes earlier.' To which goat replies 'Okay, let's do it. Let's leave 15 minutes earlier because that would solve the problem.'  Lisa: That analogy is stuck in my head because you just cannot... It doesn't know that it's too late and you can't hop into the past because it only lives in the now. This is 95% of how our brain operates. That's why we can do things like, I was walking, I was at a strategy meeting in Auckland with my business partner two days ago. We were walking along the road and he suddenly tripped and fell onto the road, right? My subconscious reacted so fast, I grabbed him right, and punched him in the guts. I didn't mean to do that but my subconscious recognised in a millimeter of a second, millionth of a second, that he was falling and I had to stop him. So this is a good side of the survival network: stopping and falling into the traffic or onto the ground.  But the downside of it is that brain is operating only in the now and it can't... Like with my father, it was going 'Save him. Save him. Save him. Why are you not saving him?' Then that's calling for an action, and then my body is agitated. The cortisol level's up. The adrenaline is up, and I'm trying to do something that's impossible to fix. That can drive you to absolute insanity when that's happening every hour, every day. Dr Don: Then that's taking a physical toll on your body because it's activating your nervous system, which is now, the cortisol levels are going up, adrenaline, right? So when your mind is in that constant state, it does very little on maintenance. It is not worried about fixing anything; it's worried about escaping or fixing the threat, because that's the number one priority.  Lisa: It doesn't know that it's not happening. I ended up with shingles for two months. I've only just gotten over it a few weeks ago. That's a definite sign of my body's, my immune system is down. Why is it down? Why can that virus that's been sitting dormant in my body for 40-something years suddenly decide now to come out? Because it's just becoming too much. I've spent too long in the fight or flight state and then your immune system is down. This is how we end up really ill.  Dr Don: We get sick. I was just actually having lunch today with a young lady and she's got some immune system issues. And I said, 'Think about it like the US Army, US military is the biggest, strongest military in the world. But if you took that military and you spread it out amongst 50 countries around the world fighting battles, and then somebody attacks the United States, I don't care how big and strong that system was, that military system was. It's going to be weakened when it gets an attack at the homefront.' So that's what was happening. So all of a sudden, now that virus that it could fight and keep dormant, it lets it pass by because it's like, 'Well, we can let that go. We'll catch that later. Right now, we got to go on the offensive and attack something else.' Lisa: Yeah, and this is where autoimmune, like your daughter experienced... Dr Don: About the Crohn's? Yep.  Lisa: Yep. She experienced that at 13 or something ridiculous? Dr Don: 14, she got it. Then she also got idiopathic pulmonary hemosiderosis which is another lung autoimmune disorder where the iron in the blood would just cause the lungs to release the blood. So her lungs just starts filling up with blood. They had no idea what caused it, that's the idiopathic part of it, and they just basically said, ‘There's no cure. She just needs to live close to a hospital because she'll bleed out if she has another attack.' Only 1 in 1.2 million people ever get that. So it's very rare so there's no research being done for it. They just basically say, ‘If you get it, live close to a hospital.' That's the strategy. Lisa: That's the way of fixing it.  Dr Don: And so both of those are autoimmune, and ever since we've gone to the program, she's hasn't had a flare-up of either one of those. Because I think our system is directly now able to address those things.  Lisa: Yeah, and can calm down. I think even people who haven't got post-traumatic stress like I've had or whatever, they've still got the day to day grind of life, and the struggle with finances, and the mortgage to be paid, and the kids to feed, and whatever dramas we're all going through. Like we talked about with COVID and this constant change that society is undergoing, and that's going to get faster and more. So this is something that we all need to be wary of: That we're not in this. I've taught and learned a lot about the coping and managing strategies, the breathing techniques, and meditation, the things, and that's what's kept me, probably, going. Dr Don: Those are great because they're... Again, that's managing it but it's good to have that because you've got to get to the root of it, which is what we were working on. But at the same time, if you don't have any coping, managing skills, life gets very difficult. Lisa: Yeah, and this is in-the-moment, everyday things that I can do to help manage the stress levels, and this is definitely something you want to talk about as well. So with me, we went through this process, and we did... For starters, you had to get my brain into a relaxed state, and it took quite a long time to get my brainwaves into a different place. So what were we doing there? How does that work with the brainwave stuff?  Dr Don: Well, when we have a traumatic event or memory, that has been stored in a very high-resolution state. So in a beta brainwave state because all your senses are heightened: sight, smell, hearing. So it's recording that and storing it in memory in a very intense state. So if I sat down with you and said, 'Okay, let's get this fixed.' And I just started trying to work directly on that memory, you're still going to be in a very high agitated state because we're going to be starting to talk about this memory. So you're going to be in a beta brainwave state trying to recalibrate a beta stored memory. That's going to be very difficult to do.  So what we do is, and that's why I use the four hours because within that first an hour and a half to two hours, we're basically communicating with the subconscious part of the brain by telling stories, symbols with metaphors, goat and snowflake, all the stories, all the metaphors that are built-in because then your brain moves into an alpha state. When it's in alpha, that's where it does restoration. So it's very prepared to start restoring. And then, if you remember, by the time we got to a couple of the traumatic memories, we only work on them for two or three minutes. Because you're in alpha, and so you've got this higher state of beta, and it recalibrates it into the same state that it's in. So if it's in alpha, it can take a beta memory, reprocess it in alpha, takes all the intensity out of it.  Lisa: So these brain waves, these beta states, just to briefly let people know, so this is speed, and correct me if I'm wrong, but it's the speed at which the brain waves are coming out. So in beta, like you'd see on ECG or something, it's sort of really fast. I think there's a 40 day... Dr Don: It's 15 to 30 hertz. Lisa: 15 to 30 hertz and then if you're in alpha, it's a lot lower than that? Dr Don: 7 to 14. Lisa: 7 to 14, and then below that is sort of when you're going into the sleep phase, either deep meditative or asleep. Dr Don: You're dreaming. Because what it's doing in dreaming is processing. So you're between 4 and 7 hertz. That's why people who have a lot of trauma have trouble sleeping. Because not only is their mind processing what it experienced during the day, it's also taking some of those old files saying, 'Well, okay, let's fix that now. Right. Let's get that.' That's where your nightmares are coming from. It was trying to get you into a processing to fix that. but it couldn't fix it. So it continues, and then when you go below 4 hertz, you go into delta. Delta is dreamless sleep and that's where the maintenance is getting done.  Lisa: That's the physical maintenance side more than the... Dr Don: Physical maintenance. Yeah, because that's not processing what it experienced anymore. What it's really now doing is saying, 'Okay, what are the issues that need to be dealt with?' So if you're very relaxed and you've had a very... Like me, right? I played hockey, so I had six concussions, 60 stitches, and never missed a hockey game. The only reason now that I understand I could do that is because I'm getting two or three times more Delta sleep than my teammates were. Lisa: Physical recuperative sleep.  Dr Don: Yeah, I was getting maximum restorative sleep. So an injury that I would have that could heal in two or three days, my teammates would two or three weeks. Because they were living in these, which I didn't know, a lot of my friends were dealing with trauma: physical, emotional, sexual abuse. I didn't know that was going on with my friends. Nobody talked about it. I didn't see it in their homes, but they were all dealing with that.  Lisa: So they are not able to get... So look, I've noticed since I've been through the program. My sleep is much better, and sometimes I still occasionally dream about Dad. But the positive dreams, if that makes sense. They're more Dad as he as he was in life and I actually think Dad's come to visit me and say, ‘Hi, give me a hug' rather than the traumatic last days and hours of his life, which was the ones that were coming in before and calling for that action and stopping me from having that restorative sleep.  I just did a podcast with Dr Kirk Parsley who's a sleep expert, ex-Navy SEAL and a sleep expert that's coming out shortly. Or I think by this time, it will be out, and understanding the importance, the super importance of both the delta and... What is the other one? The theta wave of sleep patterns, and what they do, and why you need both, and what parts of night do what, and just realising...Crikey, anybody who is going through trauma isn't experiencing sleep is actually this vicious cycle downwards. Because then, you've got more of the beta brainwave state, and you've got more of the stresses, and you're much less resilient when you can't sleep. You're going to... have health issues, and brain issues, and memory, and everything's going to go down south, basically.  Dr Don: That's why I didn't understand at the time. They just said 'Well, you're just super healthy. You heal really fast.' They had no other explanation for it. Now, I know exactly why. But it had nothing to do with my genetics. It had to do with my environment. Lisa: Just interrupting the program briefly to let you know that we have a new patron program for the podcast. Now, if you enjoy Pushing the Limits if you get great value out of it, we would love you to come and join our patron membership program. We've been doing this now for five and a half years and we need your help to keep it on here. It's been a public service free for everybody, and we want to keep it that way but to do that, we need like-minded souls who are on this mission with us to help us out. So if you're interested in becoming a patron for Pushing the Limits podcast, then check out everything on patron.lisatamati.com. That's patron.lisatamati.com.  We have two patron levels to choose from. You can do it for as little as 7 dollars a month, New Zealand or 15 dollars a month if you really want to support us. So we are grateful if you do. There are so many membership benefits you're going to get if you join us. Everything from workbooks for all the podcasts, the strength guide for runners, the power to vote on future episodes, webinars that we're going to be holding, all of my documentaries, and much, much more. So check out all the details: patron.lisatamati.com, and thanks very much for joining us.  Dr Don: That's, at the time, we just thought it was all, must have been genetics. But I realised now that it was environment as well. So maybe a genetic component to it as well, but then you take that and put that into this very beautiful, nurturing environment, I'm going to sleep processing in beta what I experienced that day and then my mind basically, at that point, is 'What do we need to work on? Not much. Let's go. Let's start now doing some maintenance.' Because it wants to address the top of item stuff first. What is it needs to be taken care of right now? Right? Those are the threats.  Once it gets the threats processed, then it can then start working on the things that are going to be the more long-term maintenance. So then it'll do that. But if it never gets out of that threat mode, it gets out for very little time. Then, if you're getting 30 minutes of delta sleep at night and I'm getting two hours, it's a no-brainer to figure out why I would heal faster.  Lisa: Absolutely, and this is independent of age and things because you've got all that that comes into it as well. Your whole chemistry changes as you get older and all this. There's other compounding issues as it gets more and more important that you get these pieces of the puzzle right.  Do you think that this is what leads to a lot of disease, cancers, and things like that as well? There's probably not one reason. There's a multitude of reasons, but it's definitely one that we can influence. So it's worth looking at it if you've got trauma in your life. People were saying to me 'Oh my God, you don't look good.' When you start hearing that from your friends, your people coming up to you and going, 'I can feel that you're not right.' People that are sensitive to you and know you very well, and you start hearing that over and over, and you start to think, 'Shit, something's got real. Maybe I need to start looking at this.'  Because it's just taking all your energy your way, isn't it, on so many levels. The restorative side and the ability to function in your life, and your work, and all of that, and that, of course, leads into depressive thoughts and that hyper-vigilant state constantly. That's really tiresome rather than being just chill, relax, enjoying life, and being able to... Like one of the things I love in my life is this podcast because I just get into such a flow state when I'm learning from such brilliant... Dr Don: You're in alpha. Lisa: I am. I am on it because this is, 'Oh. That's how that works.' And I just get into this lovely learning in an alpha state with people because I'm just so excited and curious. This is what I need to be doing more of. And less of the, if you'd see me half an hour ago trying to work out the technology. That's definitely not an alpha state for me. Dr Don: That's where they said Albert Einstein lived. Albert Einstein lived in alpha brainwave state. That's why information just float for him because there was no stress. He could then pull information very easily to float into. But if you're in a high beta brainwave state, there's too much activity. It has trouble focusing on anything because it's multiple threats on multiple fronts. So when we have a traumatic event, that's how it's being recorded. If you remember, what we talked about was there's a 400 of a millionth of a second gap in between your subconscious mind seeing the information and it going to your consciousness. So in 400 millionths of a second, your subconscious mind has already started a response into an action even though your conscious mind is not even aware of it yet.  Lisa: Yeah. Exactly what I did with rescuing my partner with the glass falling off the thing. I hadn't reached that logically. Dr Don: It's funny because that's one of the things that I talked about ,which is sort of, give us all a little bit of grace. Because if you've had a lot of trauma, you're going to respond a certain way. How could you not? If your mind's filtering into all of that, of course you're going to respond with that kind of a response because your mind is prone to go into that action very, very quickly. So we can give ourselves a little bit of grace in understanding that of course, you're going to do that, right? And not beat ourselves up.  Because you know what I talked about with everybody, there's nothing wrong with anybody. There's nothing wrong with anybody's mind. Everybody's mind is fine except you are experiencing something different than I experienced so your mind kept responding to it, and mine didn't have that. So you had multiple... Think about we have a hundred percent of our energy on our phone when we wake up in the morning, right? Fully powered up. You fire the phone up and eight programs open up, right? And mine has one.  Lisa: Yeah. You're just focusing on what you need to. Dr Don: Then noon comes, and you're having to plug your phone back in because you're out of energy.  Lisa: That's a perfect analogy. You're just burning the battery. My all is a hundred windows open in the back of my brain that is just processing all these things and so now, I can start to heal. So having gone through this process with you, like you said, we worked on a number of traumatic experiences, and I went through them in my mind. And then you did certain things, made me follow with my eyes and track here, and my eyes did this, and then, we pulled my attention out in the middle of the story and things. That helped me stay in that alpha state, brainwave state as I probably now understand while I'm still reliving the experience. That's sort of taking the colour out of it so that it's now sort of in a black and white folder. Now, it can still be shared, and it hasn't taken away the sadness of... Dr Don: Because it is sad that these things happen but that's not the response for an action which is that fear or anger, right? That dysregulation of the nervous system. That's what we want to stop, because that is what is going to affect health, enjoyment of life and everything else.  Lisa: Wow, this is so powerful. Yeah, and it's been very, very beneficial for me and helped me deal. For me, it also unfolded. Because after the four hour period with you, I had audiotapes and things that are meditations to do every day for the next 30 days. What were we doing in that phase of the recovery? What were you targeting in those sort of sessions?  Dr Don: So if you remember what we talked about, we have two memory systems. The explicit memory is what we worked on on that four hours. That's detail, events, and experiences. Once we get the mind processing through that, then we have to work on the same memory animals have, which is that associative repetitive memory. So you've built a series of codes on how to respond to threats, and that has come in over repetition and associations. So the audios are designed to start getting you now to build some new neural pathways, some new ways to respond because your mind won't switch a pattern instantly. It can switch a memory instantly, but a pattern is something that got built over a period of time. So it's like a computer. If I'm coding on my computer, I can't take one key to stop that code. I have to write a new code. Yeah, so what we're doing over the 30 days is writing new code. Lisa: Helping me make new routines and new habits around new neural pathways, basically.  Dr Don: You don't have that explicit memory interfering with the pathways. Because now, it's not constantly pulling you out, going back into an action call. It's basically now able to look at this information and these codes that got built and say, 'Okay, what's a better way? So do we have a better way of doing it?' Or 'Show me that code. Write that code.' If that code looks safer, then your mind will adopt that new code. Lisa: This is why, I think for me, there was an initial, there was definitely... Like the nightmares stopped, the intrusive every minute, hour triggering stopped, but the process over the time and the next... And I'm still doing a lot of the things and the meditations. It's reinforcing new habit building. This is where... Like for people dealing with addictions, this is the path for them as well, isn't it?  Dr Don: Yeah. Because I talked about addiction as a code. I don't believe it's a disease. Your mind has found a resource to stop pains, and your subconscious mind is literal. It doesn't see things as good or bad, or right or wrong. It's literal. 'Did that stop the pain? Let's do that.' Because it's trying to protect you. So if you've now repeated it over and over, not only have you stopped the pain, but you've built an association with a substance that is seen as beneficial. Lisa: Because your brain sees it as medicine when you're taking, I don't know, cocaine or something. It sees it as essential to your life even though you, on a logical level, know that, ‘This is destroying me and it's a bad thing for me.' Your subconscious goes, 'No, this is a good thing and I need it right now.' Dr Don: Because it's in the present, when does it want the pain to stop? Now. So it has no ability to see a future or a past. Your subconscious is in the moment. So if you take cocaine, the logical part of your brain goes, 'Oh, this is going to create problems for me. I'm going to become addicted.' Right? Your subconscious goes, ‘Well, the pain stopped. We don't see that as a bad thing.' I always use the analogy: Why did people jump out of the buildings at 911? They weren't jumping to die. They were jumping to live because when would they die? Now, if they jump, would they die? No. They stopped the death. So even jumping, which logically makes no sense, right? But to the subconscious mind, it was going to stop the pain now.  Lisa: Yeah, and even if it was two seconds in the future that they would die, your brain is going...  Dr Don: It doesn't even know what two seconds are.  Lisa: No. It has no time. Isn't it fascinating that we don't have a time memory or understanding in that part of the brain that runs 95% of the ship?  Dr Don: It's like what Albert Einstein said, ‘There's no such thing as time.' So it's like an animal. If an animal could communicate and you say, 'What time is it?' That would make no sense to an animal. 'What do you mean? It's now.' 'What time is it now?' 'Now. Exactly.' Lisa: It's a construct that we've made to... Dr Don: Just to explain a lot of stuff, right? When something happens.  Lisa: Yeah, and this is quite freeing when you think of it. But it does make a heck of a lot of sense. So people are not being destructive when they become drug addicts or addicted to nicotine, or coffee, or chocolate. They're actually trying to stop the pain that they're experiencing in some other place and fix things now. Even though the logical brain... Because the logical brain is such a tiny... Like this is the last part of our evolution, and it's not as fully...  We can do incredible things with it at 5%. We've made the world that we live in, and we're sitting here on Zoom, and we've got incredible powers. But it's all about the imagination, being able to think into the future, into the past, and to make correlations, and to recognise patterns. That's where all our creativity and everything, or not just creativity, but our ability to analyse and put forth stuff into the world is happening. But in actual, we're still like the animals and the rest of it. We're still running at 95%, and that's where we can run into the problems with these two.  Dr Don: Because you got two systems. You got a very advanced system operating within a very primitive system, and it hasn't integrated. It's still integrating, right? So if there's a survival threat, survival will always override reason and logic, because it's designed to protect you. So there's no reason and logic that will come in if there's a survival threat. It's just going to respond the way it knows, does this Google search, 'What do we know about this threat? How do we know to protect ourselves, and we'll go instantly into survival mode.' Again, there's the reason and logic. Why would you jump out of a building, right? If you applied reason and logic, you wouldn't have jumped, right? People will say, 'Well, but they still jumped.' Yes, because reason and logic didn't even come into the process. It was all about survival.  Lisa: Yeah. When the fire is coming in it was either... Dr Don: 'Am I going to die out now or I'm going to move and not die now?'  Lisa: Yeah, and we're also prone to movement when we're in agitation and in an agitated state, aren't we? Basically, all of the blood and the muscles saying, 'Run, fight, do something. Take action.' Dr Don: That's why when people get into depression, it's the absence of those emotions.  Lisa: Yeah, and people feel exhaustion.  Dr Don: Yeah. The mind kept calling for an action using anger, for example, but you can't do the action because it's not happening, so it shuts down to protect you and stops calling for any emotion, and that's depression. So the key to get out of depression is actions. It's to get something happening. So in a lot of people who are depressed, what do I tell them to do? 'Start moving. Start exercising. Get out. Start doing things.' Right?  Lisa: So I run ultras. Dr Don: Exactly. Perfect example, right?  Lisa: Yeah, because I was. I was dealing with a lot of shit in my life at the time when I started doing ultra-marathons. To run was to quiet the pain and to run was to be able to cope and to have that meditative space in order to work through the stuff that was going on in my life. And I know even in my husband's life, when he went through a difficult time, that's when he started running. So running can be a very powerful therapeutic, because there is a movement, and you're actually burning through the cortisol and the adrenaline that's pouring around in your body. Therefore, sitting still and that sort of things was just not an option for me. I had to move. And it explains what, really. It's calling the movement. Like it was a movement because I couldn't fix the other thing.  Dr Don: That's what they'll tell you to do. To get out of depression is to move. What I say is the way to get out of depression is to get your mind to resolve what it's been asking for. Lisa: It's going a little deeper.  Dr Don: Yeah. So it's going down and saying, 'Okay, why has it been getting you angry and now, it shut down from the anger?' Because it's been trying to get you in your situation. 'Don't let Dad die. Don't let this happen.' Right? So because you couldn't do it, it just shuts down. Makes perfect sense but when we get to the resolution that there is no action required, there's no need for the depression anymore. The depression will lift because there's no more call for an action.  Lisa: I can feel that in me, that call. Anytime that anything does still pop up, I sort of acknowledge the feeling and say, 'There is no call for action here. This is in the past. This is a memory.' So I do remind myself that when things do still pop up from time to time now, as opposed to hourly. I go, 'Hey, come back into the now. This is the now. That was the then that's calling for an action. This is why you're doing thing.' Even that understanding

Budete-li hledat mezi českými spisovateli osud, na kterém by se daly popsat složité zákruty druhé poloviny 20. století, nemůžete minout dramatika a prozaika Milana Jariše. Nad jeho životem se v pořadu Portréty zamyslí historik Eduard Burget z Ústavu pro českou literaturu Akademie věd.

Budete-li hledat mezi českými spisovateli osud, na kterém by se daly popsat složité zákruty druhé poloviny 20. století, nemůžete minout dramatika a prozaika Milana Jariše. Nad jeho životem se v pořadu Portréty zamyslí historik Eduard Burget z Ústavu pro českou literaturu Akademie věd.

Nad slovami sv. Ignáca Brjančaninova - Pole 1 - s. 43-46. - Filokalia Live - pravidelné online stretnutia prostredníctvom ZOOM. Zámerom je spoznávanie a osvojovanie umenia duchovného života štúdiom učenia svätých otcov. Pondelkové stretnutia sú venované úvodu do duchovného života podľa manuálu sv. Ignáca Brjančaninova - Pole. Kto by mal záujem o zakúpenie tejto publikácie, nájde ju v ponuke Filokalie, jej vlastnenie však nie je pro toto štúdium nevyhnutné. Štvrtkové stretnutia sú venované uvažovaniu nad dielom Evergetinos. Ide o rozsiahlu zbierku výrokov a krátkych príbehov zo života púštnych otcov, ktorá bola zostavená mníchom Pavlom v 11. storočí. Každá kapitola dáva dôkladné vysvetlenie predstavenej témy a postupne čitateľa sprevádza od položenia základných kameňov duchovného život až po jeho výšiny. Stretnutia sa konajú každý pondelok a štvrtok o 20.00 hod. V prípade záujmu sa môžete zaregistrovať a e-mailom Vám bude zaslaný Zoom link pre vstup na stretnutie.  

Nad městem Bochov, zhruba mezi Karlovými Vary a Toužimí, najdeme velmi pozoruhodné místo – jedná se o pozůstatky pozdně gotického hradu Hartenštejn z 15. století. Krom zříceniny jako takové se zde nachází také opravená vyhlídková věž, zvaná Karlovarská.

Od pondelka sa prvých päť našich okresov zafarbí do čiernej farby covid automatu. Obmedzenia sa tak dotknú aj očkovaných - zakázané sú večierky, svadobné oslavy a mení sa aj fungovane reštaurácii. Je možné, že sa do čierna sfarbí celé Slovensko? O aktuálne situácii sa rozprávame s matematikom z Veda pomáha Richardom Kollárom. Podľa neho sa s covidom stretne do 2 mesiacov takmer každý. „Všetci občania Slovenska sa v najbližších dvoch mesiacoch stretnú s koronavírusom. Dostanú sa k nim vírusové častice, každý ich vdýchne. Tí, ktorí majú silnú imunitnú reakciu po očkovaní alebo prekonaní si to ani nevšimnú,” hovorí v podcaste. V druhej časti podcastu sa pozrieme na kupčenie s bakalárskymi či magisterskými prácami. Nadácia Zastavme korupciu fenomén podrobila analýze a hovorí, že takto nečestne môže na našich vysokých školách absolvovať 15 percent študentov. A práce za peniaze im majú dokonca písať zamestnanci vysokých škôl!  Obchodovanie so záverečnými prácami nadácia preverovalo formou mystery shoppingu, teda vydávali sa za študentov so záujmom o kúpu vysokoškolskej práce. Preverili tak dvadsiatku webových ponúk. S akými výsledkami? Predstaví ich Martin Suchý z Nadácie Zastavme korupciu. Moderuje Denisa Hopková. Spolupracoval Jaroslav Barborák.

We are living through multiple crises. Not only are we going through the COVID-19 pandemic, but there is also a hidden epidemic going on. Over the years, people have become more obese. In 2013, only 34% of our population was within a healthy BMI range, and this statistic is falling exponentially over the years. We need to take action now because obesity is not about how you look — it's about real health consequences.  Dr Katherine Sowden joins us in this episode to talk about women's and public health. She explains how obesity changes our bodies and causes various diseases and cancers. She shares that it's often not even people's fault. There's a range of factors that encourage this epidemic. Exacerbating the socioeconomic and cultural factors is the food industry. Dr Katherine emphasises that we need to start educating ourselves on our health. Only then can we make better choices to prevent these diseases. If you want to know more about taking preventive measures against cancer and other diseases, this episode is for you.    Here are three reasons why you should listen to the full episode: Learn about the current state of public health and how to be a proactive patient. Discover the ways obesity can lead to an increased risk of cancer, particularly in women. Know how you can make better health choices to avoid developing cancer.   Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron!  A new program, BoostCamp, is coming this September at Peak Wellness! Listen to other Pushing the Limits episodes with Dr Elena Seranova:  #183: Sirtuin and NAD Supplements for Longevity  #189: Understanding Autophagy and Increasing Your Longevity   Connect with Dr Katherine: Auckland Women's Gynaecology I Ormiston Specialists I Email   Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/.   Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, Run Longer  Without Burnout & Injuries Have you struggled to fit in training in your busy life? Maybe you don't know where to start, or perhaps you have done a few races but keep having motivation or injury troubles? Do you want to beat last year's time or finish at the front of the pack? Want to run your first 5-km or run a 100-miler? ​​Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle?  Go to www.runninghotcoaching.com for our online run training coaching.   Health Optimisation and Life Coaching If you are struggling with a health issue and need people who look outside the square and are connected to some of the greatest science and health minds in the world, then reach out to us at support@lisatamati.com, we can jump on a call to see if we are a good fit for you. If you have a big challenge ahead, are dealing with adversity, or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, then contact us at support@lisatamati.com.   Order My Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again, but I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books.   Lisa's Anti-Ageing and Longevity Supplements  NMN: Nicotinamide Mononucleotide, an NAD+ precursor Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, is being dramatically decreased over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. Founded by scientists, NMN Bio offers supplements of the highest purity and rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful, third party tested, NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of ageing while designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health   My  ‘Fierce' Sports Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection.   Episode Highlights [04:06] The Current State of Women's Health One of the most significant issues in women's health is the normalisation of obesity.  This situation comes from a lack of understanding of the importance of nutrition and movement to our health.  Endometrial cancer is a progressive order that is caused by having too much estrogen. One of its leading causes is obesity.  Obesity can also decrease fertility since it affects the ovulatory cycle by affecting the production of progesterone.  Before, we used to see endometrial cancer affecting women over 40, but now there are cases as young as under 20.  [07:59] Effects of Obesity Women's relative risk for endometrial cancer is one if they have a normal BMI. However, when they're in the range of 30-35 and over 40, this is raised to 2.5 and 7.1 respectively.  There are now many obese young women who are in this constant state of a hyper estrogenic environment.  The definitive treatment of this cancer is hysterectomy, making a huge impact on women's choice for reproduction.    In addition, obesity can increase the risk of breast cancer too. [10:43] What Changes Does Obesity Make?  Obesity leads to an abnormally high aromatase gene expression, which is in charge of estrogen production.  With obesity, the body converts more of the androgen peripheral tissue into estrogen too.  This problem does not apply only to women. Obese men also have hormone issues and tend to have feminine features. [14:04] How the Food Industry Affects Our Health One of the main drivers of the obesity epidemic is the wide availability of obesogenic food.  Lower-income families tend to consume more of these foods since they are cheaper than healthier options.  We can remove taxes on fruits and vegetables to help address the problems in the food industry — as other countries have done.  Even if junk foods seem cheap, these are costing the country more. Public health will collapse as more young people develop diseases.  Obesity doesn't just cause cancer — it can also lead to diabetes and heart disease.  [16:19] What Needs to Change?  The market needs to change to make healthy foods more accessible. The food industry also needs to assess the way they use additives and preservatives.  It's not totally our fault that we're obese. This epidemic is driven by socioeconomic and cultural factors, in addition to the food industry.  Widespread normalisation of a high BMI is also harmful since people don't understand its consequences.  While doctors can help treat your diseases with pills and surgeries, it will always come with risks. It's your responsibility to prevent hospitalisation. Medication should not be your first and only option.  [23:19] Start with Educating Yourself Preventing disease progression starts at an early stage.  Some medical interventions may not be the cure to fix your health. There is a need for a holistic approach to health.  In public health settings, most doctors only have 20 minutes to get to know a patient. This amount of time does not give them a complete picture of what the patient needs.  Personalised health care starts with self-education. Do your research so you can ask specific questions to your doctor within the limited timeframe given to you. Dr Katherine shares that not only does obesity have compounding effects on health, it can also affect surgeries! Learn more about this in the complete episode.   [31:13] How Obesity has Risen Over the Years Even if our lifespans have increased because of medicine, people are also dying earlier because of diseases.  A study in New Zealand found that the standardised incidence of endometrial cancer used to be 1.9 per 100,000 population in 1996.  This rate increased to 24.2 in 2012, with the Pacific Islanders' at 46.06.  In 2013, around 34% of the population were within the range of a healthy BMI. This percentage has decreased sharply over the years.  Preventing cancers, such as endometrial cancers, starts with losing weight and changing lifestyles.  [37:05] Start Early It's more difficult to reverse cancers and diseases than taking preventive measures.  Diseases and cancers don't happen overnight. It's the result of malignant states developing over time.  Not all cancers are preventable, but we can decrease our chances of developing them, especially with estrogen-dependent cancers.  [40:20] Stop the Vicious Cycle Nowadays, it's commonly seen as politically incorrect to discuss obesity. Remember that our physical states impact our health, whether we like to hear them or not.  Understand the consequences of obesity. These include the increased likelihood of infertility, cancer risk, diabetes, dementia, heart disease, and many more illnesses.  Start with adopting lifestyle changes in terms of nutrition and movement.  Eating unhealthy foods can cause a vicious cycle of degrading health, both physically and mentally.  You can also seek more personalised healthcare from health coaches and other allied health professionals.    7 Powerful Quotes ‘We tax cigarettes, we take alcohol. Why aren't we taxing some of this junk food? It is of no benefit to people whatsoever.' ‘We need to do something and even if it is unpopular. So for example, taxing sugary food and drinks. It's got to be worthwhile.' ‘We can do operations that do amazing things, and really cure people of cancer, and improve their quality of life, but equally it shouldn't be the first option.' ‘But I think we've always got to look at the patient as a whole person. The least invasive cure, the better.' 'The more people we can keep out of the hospital, the better because it means we can deliver quality personalised health care.' ‘The more you can educate yourself, the better. So that when you get that 20 minutes in the public system, you've got the questions to ask, you know what you're going in for.' ‘It's also seen as politically incorrect to discuss obesity. But it's not politically incorrect. That's factual and it's a crisis. We need to stop pussyfooting around it.'   About Katherine Dr Katherine Sowden is a highly respected gynaecologist and has been the Clinical Lead in Counties Manukau Health since 2014. She is also a Consultant Gynaecologist in Auckland Women's Gynaecology and Ormiston Specialist Centre.  Dr Katherine is a fellow of the Royal Australian and New Zealand College of Obstetricians and Gynaecologists. She is currently the departmental lead for non-tertiary gynaecological oncology and focuses on the management of premalignant gynaecological conditions.  She provides a wide range of gynaecology services. You can find out more about her practice in Auckland Women's Gynae and Ormiston Specialists.  You can also reach Katherine by email.       Enjoyed This Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can make better health choices to prevent cancer. Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa

Už 125 let uplynulo 11. října od narození slovenského politika Jána Ursínyho – muže, kterému se v roce 1946 podařilo na Slovensku porazit komunisty. Proč se na něj zapomnělo? Nad tím v pořadu Portréty přemýšlí slovenský publicista Ján Bábik. „Byl to demokrat každým coulem,“ říká o Ursínym publicista Ján Bábik.

Už 125 let uplynulo 11. října od narození slovenského politika Jána Ursínyho – muže, kterému se v roce 1946 podařilo na Slovensku porazit komunisty. Proč se na něj zapomnělo? Nad tím v pořadu Portréty přemýšlí slovenský publicista Ján Bábik. „Byl to demokrat každým coulem,“ říká o Ursínym publicista Ján Bábik.

durée : 02:00:01 - Le 5/7 - Xavière Guerlay, Flore Talamon et Nadège Buquet sont les invitées du 5/7

durée : 00:06:49 - L'invité de 6h20 - par : Mathilde MUNOS - Publication de la BD "Lanceurs d'alerte" aux éditions Delcourt : Flore Talamon autrice de la BD et Nadège Buquet, coprésidente de l'association "La Maison des lanceurs d'alerte" sont les invitées du 6h20.

Už pri jej zvolení viaceré organizácie venujúce sa ochrane a právam detí bili na poplach. Novovzniknutý úrad, ktorý má hájiť záujmy tých najmenších, bol totiž obsadený politickou nominantkou strany Smer - Vierou Tomanovou. Jej funkcia v role detskej ombudsmanky sa po rokoch chýli ku koncu a pri zhodnocovaní jej práce sa vynárajú viaceré pochybnosti, či jej pôsobenie bolo skutočne v mene detí alebo v mene presadzovania vlastných záujmov. O Viere Tomanovej aj jej prípadnej nástupkyni sa Jana Maťková rozprávala so Xéniou Makarovou z Nadácie Zastavme korupciu, ktorá činnosť úradu komisára pre deti dlhodobo detailne sleduje. Zdroj zvukov: TASR, SME, Youtube/Komisár pre deti - Spomínané v podcaste: Rozhovor s možnou kandidátkou na detskú ombudsmanku Katarínou Hatrákovou. Diel investigatívnej relácie Cez čiaru o Viere Tomanovej a jej odporúčaní na konkrétneho súkromného advokáta. Odporúčanie: Rada sa občas vrátim do hudobnej minulosti a počúvam interpretov a interpretky, ktoré som doteraz obchádzala. V poslednom období mi tak učarovala stará tvorba Sade a Erykah Badu.  Je príjemná, upokojujúca, miestami až ezoterická. A som zvedavá aj na vaše tipy - čo ďalšie z hudobnej histórie treba poznať a vypočuť si? Napíšte nám na dobrerano@sme.sk alebo do Podcastového klubu denníka SME na Faceboku. - Ak máte pre nás spätnú väzbu, odkaz alebo nápad, napíšte nám na dobrerano@sme.sk  –  Všetky podcasty denníka SME nájdete na sme.sk/podcasty  –  Podporte vznik podcastu Dobré ráno a kúpte si digitálne predplatné SME.sk na sme.sk/podcast  –  Odoberajte aj denný newsletter SME.sk s najdôležitejšími správami na sme.sk/brifing –  Ďakujeme, že počúvate podcast Dobré ráno.

Nad grą „Akademia Superbohaterów” pracowałem dwa lata. W tym nagraniu wyjaśniam jak ten proces wyglądał i opowiadam o zasadach gry. Grę można zamówić w sklepie Fundacji Nauka. To Lubię – www.sklep.naukatolubie.pl. Do koszyka możecie też dołożyć książkę o polskich naukowcach.

NAD is a supplement. Similar to testosterone, if we are not producing enough, we want to supplement it. Well, NAD enhances the ability of Vitamin B3 to support cellular healing in the body. This is a naturally occurring element in the body in which production can decrease for several reasons. Substance abuse or any abuse the body suffers could potentially erode the production of this in our body, as well as aging. I am talking with Mike Godfrey and Stephanie Rose who are working together on a research project entitled “Perceptions of Mental Health and Recovery after Receiving NAD Treatment: A different Approach for Recovery and Withdrawal.” Although I do not support an abstinent-only approach, NAD seems to be a route for those that want abstinence. Withdrawal is painful no matter how you slice it, and when it comes to stimulants there has previously been no help, or harm-reductive approach, to detoxing. NAD is not only being used to detox people from stimulants but for those who are ready to leave their MAT (suboxone/methadone) behind, as well as alcohol. Not everyone is going to want to move into abstinence but for those that are interested in that route, NAD seems to get people to a place where they can step into sobriety with a mind that is thinking clearer than otherwise would be possible. Since doing this interview I have been taking NAD, I have not experienced any noticeable shift in my thinking or behaving. However, it should be noted that I didn't take any tests to see the level of NAD I was producing, so it very well may have been a wash. I do have an MRI coming up in Dec for my MS, if I have significant shrinking in my legions or if it aids in any way I can detect, I will definitely let you know. The center doing the research is Incura in North Little Rock Arkansas. https://incura.life/ @incura.life on Instagram Dr. Stephanie Rose bio https://uca.edu/healthsci/facultystaff/rose/ Questions: Would you try NAD if you were in a position to face detoxing? Where do you see NAD treatment, taking the information you have heard here, being able to offer benefit. Is NAD offered in your treatment facility? The Recover Yourself approach is a path to your total wellness: Physical, Emotional, and Spiritual (however you define that). If you have pain or a major diagnosis, spiritual misgivings, or are easily emotionally disrupted, you are not whole. We give up on ourselves so easily. As children, we lived under the influence of our parents and that, for many, continues from one relationship to another. There is a you that you will be, which you have never known, that you can Recover To. Contact me when you are ready to step into that. o Patreon https://www.patreon.com/RecoverYourself o Instagram https://www.instagram.com/martinjon/ o Facebook https://www.facebook.com/MartinJonRecoveryMentor o LinkedIn https://www.linkedin.com/in/martinjonarts/ o Link Tree https://linktr.ee/martinjon o Venmo: MartinJon_Garcia --- Send in a voice message: https://anchor.fm/martinjon/message Support this podcast: https://anchor.fm/martinjon/support

Dr. Ken Starr is an authority in the field of Addiction Medicine and Wellness. Since founding the Ken Starr MD Wellness Group in 2012 after the overdose death of his brother, he has been committed to helping patients achieve lasting sobriety and improve the quality of their lives. Dr. Starr utilizes medications, supplements, traditional and non-traditional therapies that help people overcome chemical dependency and live the lives they know are possible.Dr. Starr's passion about NAD therapy has enabled his clinic to become the most experienced provider of NAD treatments on the West Coast. He has introduced nutritional IV Infusions into the practice so all patients can affordably and comfortably work towards their wellness goals.Dr. Starr is board certified in both Addiction Medicine and Emergency Medicine. He takes a personal and compassionate interest in each of his patients and is easily available for patients and their families at all times.Listen and subscribe to the Roscoe's Wetsuit Neuro Podcast:Apple Podcasts: https://podcasts.apple.com/us/podcast/roscoes-wetsuit-neuro-podcast/id1478352736Spotify: https://open.spotify.com/show/0E8Ui8JNpkjA9LDqbfXnb5Stitcher: https://www.stitcher.com/show/roscoes-wetsuitYouTube: https://www.youtube.com/channel/UCoDsVTNVrQztFeRMzIU72_wwww.roscoeswetsuitneuro.com

Raspberries, ellagic acid reveal benefits in two studies Oregon State University, October 1, 2021.    Articles that appeared recently in the Journal of Berry Research report that raspberries and compounds present in the fruit could help support healthy body mass and motor function, including balance, coordination and strength.   In one study, Neil Shay and colleagues at Oregon State University fed mice a high fat, high sugar diet plus one of the following: raspberry juice concentrate, raspberry puree concentrate, raspberry fruit powder, raspberry seed extract, ellagic acid (a polyphenol that occurs in a relatively high amount in raspberries), raspberry ketone, or a combination of raspberry ketone and ellagic acid. Additional groups of animals received a high fat, high sugar diet alone or a low fat diet.   While mice that received the high fat and sugar diet alone experienced a significant increase in body mass, the addition of raspberry juice concentrate, raspberry puree concentrate or ellagic acid plus raspberry ketone helped prevent this effect. Of note, mice that received raspberry juice concentrate experienced gains similar to those of animals given a low fat diet. "We hope that the findings from this study can help guide the design of future clinical trials," Dr Shay stated.   In another study, Barbara Shukitt-Hale, PhD, and her associates at Tufts University's Human Nutrition Research Center on Aging gave 19 month old rats a control diet or a diet enhanced with raspberry extract for 11 weeks. Psychomotor behavior was assessed during week 7 and cognitive testing was conducted during weeks 9-10.   Animals that received raspberry performed better on psychomotor coordination and balance, and had better muscle tone, strength and stamina than those that received a control diet. "These results may have important implications for healthy aging," stated Dr Shukitt-Hale. "While further research in humans is necessary, animal model studies are helpful in identifying deficits associated with normal aging."       Massage doesn't just make muscles feel better, it makes them heal faster and stronger Harvard University, October 6, 2021 Massage has been used to treat sore, injured muscles for more than 3,000 years, and today many athletes swear by massage guns to rehabilitate their bodies. But other than making people feel good, do these "mechanotherapies" actually improve healing after severe injury? According to a new study from researchers at Harvard's Wyss Institute for Biologically Inspired Engineering and John A. Paulson School of Engineering and Applied Sciences (SEAS), the answer is "yes." Using a custom-designed robotic system to deliver consistent and tunable compressive forces to mice's leg muscles, the team found that this mechanical loading (ML) rapidly clears immune cells called neutrophils out of severely injured muscle tissue. This process also removed inflammatory cytokinesreleased by neutrophils from the muscles, enhancing the process of muscle fiber regeneration. The research is published in Science Translational Medicine. "Lots of people have been trying to study the beneficial effects of massage and other mechanotherapies on the body, but up to this point it hadn't been done in a systematic, reproducible way. Our work shows a very clear connection between mechanical stimulation and immune function. This has promise for regenerating a wide variety of tissues including bone, tendon, hair, and skin, and can also be used in patients with diseases that prevent the use of drug-based interventions," said first author Bo Ri Seo, Ph.D., who is a Postdoctoral Fellow in the lab of Core Faculty member Dave Mooney, Ph.D. at the Wyss Institute and SEAS. Seo and her coauthors started exploring the effects of mechanotherapy on injured tissues in mice several years ago, and found that it doubled the rate of muscle regeneration and reduced tissue scarring over the course of two weeks. Excited by the idea that mechanical stimulation alone can foster regeneration and enhance muscle function, the team decided to probe more deeply into exactly how that process worked in the body, and to figure out what parameters would maximize healing. They teamed up with soft robotics experts in the Harvard Biodesign Lab, led by Wyss Associate Faculty member Conor Walsh, Ph.D., to create a small device that used sensors and actuators to monitor and control the force applied to the limb of a mouse. " The device we created allows us to precisely control parameters like the amount and frequency of force applied, enabling a much more systematic approach to understanding tissue healing than would be possible with a manual approach," said co-second author Christopher Payne, Ph.D., a former Postdoctoral Fellow at the Wyss Institute and the Harvard Biodesign Lab who is now a Robotics Engineer at Viam, Inc.  Once the device was ready, the team experimented with applying force to mice's leg muscles via a soft silicone tip and used ultrasound to get a look at what happened to the tissue in response. They observed that the muscles experienced a strain of between 10-40%, confirming that the tissues were experiencing mechanical force. They also used those ultrasound imaging data to develop and validate a computational model that could predict the amount of tissue strain under different loading forces. They then applied consistent, repeated force to injured muscles for 14 days. While both treated and untreated muscles displayed a reduction in the amount of damaged muscle fibers, the reduction was more pronounced and the cross-sectional area of the fibers was larger in the treated muscle, indicating that treatment had led to greater repair and strength recovery. The greater the force applied during treatment, the stronger the injured muscles became, confirming that mechanotherapy improves muscle recovery after injury. But how? Evicting neutrophils to enhance regeneration To answer that question, the scientists performed a detailed biological assessment, analyzing a wide range of inflammation-related factors called cytokines and chemokines in untreated vs. treated muscles. A subset of cytokines was dramatically lower in treated muscles after three days of mechanotherapy, and these cytokines are associated with the movement of immune cells called neutrophils, which play many roles in the inflammation process. Treated muscles also had fewer neutrophils in their tissue than untreated muscles, suggesting that the reduction in cytokines that attract them had caused the decrease in neutrophil infiltration. The team had a hunch that the force applied to the muscle by the mechanotherapy effectively squeezed the neutrophils and cytokines out of the injured tissue. They confirmed this theory by injecting fluorescent molecules into the muscles and observing that the movement of the molecules was more significant with force application, supporting the idea that it helped to flush out the muscle tissue. To pick apart what effect the neutrophils and their associated cytokines have on regenerating muscle fibers, the scientists performed in vitro studies in which they grew muscle progenitor cells (MPCs) in a medium in which neutrophils had previously been grown. They found that the number of MPCs increased, but the rate at which they differentiated (developed into other cell types) decreased, suggesting that neutrophil-secreted factors stimulate the growth of muscle cells, but the prolonged presence of those factors impairs the production of new muscle fibers. "Neutrophils are known to kill and clear out pathogens and damaged tissue, but in this study we identified their direct impacts on muscle progenitor cell behaviors," said co-second author Stephanie McNamara, a former Post-Graduate Fellow at the Wyss Institute who is now an M.D.-Ph.D. student at Harvard Medical School (HMS). "While the inflammatory response is important for regeneration in the initial stages of healing, it is equally important that inflammation is quickly resolved to enable the regenerative processes to run its full course." Seo and her colleagues then turned back to their in vivo model and analyzed the types of muscle fibers in the treated vs. untreated mice 14 days after injury. They found that type IIX fibers were prevalent in healthy muscle and treated muscle, but untreated injured muscle contained smaller numbers of type IIX fibers and increased numbers of type IIA fibers. This difference explained the enlarged fiber size and greater force production of treated muscles, as IIX fibers produce more force than IIA fibers. Finally, the team homed in on the optimal amount of time for neutrophil presence in injured muscle by depleting neutrophils in the mice on the third day after injury. The treated mice's muscles showed larger fiber size and greater strength recovery than those in untreated mice, confirming that while neutrophils are necessary in the earliest stages of injury recovery, getting them out of the injury site early leads to improved muscle regeneration. "These findings are remarkable because they indicate that we can influence the function of the body's immune system in a drug-free, non-invasive way," said Walsh, who is also the Paul A. Maeder Professor of Engineering and Applied Science at SEAS and whose group is experienced in developing wearable technology for diagnosing and treating disease. "This provides great motivation for the development of external, mechanical interventions to help accelerate and improve muscle and tissue healing that have the potential to be rapidly translated to the clinic." The team is continuing to investigate this line of research with multiple projects in the lab. They plan to validate this mechanotherpeutic approach in larger animals, with the goal of being able to test its efficacy on humans. They also hope to test it on different types of injuries, age-related muscle loss, and muscle performance enhancement. "The fields of mechanotherapy and immunotherapy rarely interact with each other, but this work is a testament to how crucial it is to consider both physical and biological elements when studying and working to improve human health," said Mooney, who is the corresponding author of the paper and the Robert P. Pinkas Family Professor of Bioengineering at SEAS. "The idea that mechanics influence cell and tissue function was ridiculed until the last few decades, and while scientists have made great strides in establishing acceptance of this fact, we still know very little about how that process actually works at the organ level. This research has revealed a previously unknown type of interplay between mechanobiology and immunology that is critical for muscle tissue healing, in addition to describing a new form of mechanotherapy that potentially could be as potent as chemical or gene therapies, but much simpler and less invasive," said Wyss Founding Director Don Ingber, M.D., Ph.D., who is also the Judah Folkman Professor of Vascular Biology at (HMS) and the Vascular Biology Program at Boston Children's Hospital, as well as Professor of Bioengineering at SEAS.   Vitamin E could help protect older men from pneumonia University of Helsinki (Finland), October 7 2021.    An article that appeared in Clinical Interventions in Aging reported a protective role for vitamin E against pneumonia in older men.   For the current investigation, Dr Harri Hemilä of the University of Helsinki, Finland analyzed data from the Alpha-Tocopherol Beta-Carotene (ATBC) Cancer Prevention Study conducted in Finland. The trial included 29,133 men between the ages of 50 to 69 years who smoked at least five cigarettes daily upon enrollment. Participants received alpha tocopherol (vitamin E), beta carotene, both supplements, or a placebo for five to eight years.   The current study was limited to 7,469 ATBC participants who started smoking at age 21 or older. Among this group, supplementation with vitamin E was associated with a 35% lower risk of developing pneumonia in comparison with those who did not receive the vitamin.  Light smokers who engaged in leisure time exercise had a 69% lower risk compared with unsupplemented members of this subgroup. The risk in this subgroup of developing pneumonia by age 74 was 12.9%.   Among the one-third of the current study's population who quit smoking for a median period of two years, there was a 72% lower risk of pneumonia in association with vitamin E supplementation. In this group, exercisers who received vitamin E experienced an 81% lower pneumonia risk.   Dr Hemilä observed that the benefit for vitamin E in this study was strongest for older subjects—a group at higher risk of pneumonia.   "The current analysis of individual-level data suggests that trials on vitamin E and pneumonia on nonsmoking elderly males are warranted," he concluded.       Toxic fatty acids to blame for brain cell death after injury New York University, October 7, 2021 Cells that normally nourish healthy brain cells called neurons release toxic fatty acids after neurons are damaged, a new study in rodents shows. This phenomenon is likely the driving factor behind most, if not all, diseases that affect brain function, as well as the natural breakdown of brain cells seen in aging, researchers say. Previous research has pointed to astrocytes—a star-shaped glial cell of the central nervous system—as the culprits behind cell death seen in Parkinson's disease and dementia, among other neurodegenerative diseases. While many experts believed that these cells released a neuron-killing molecule to "clear away" damaged brain cells, the identity of this toxin has until now remained a mystery. Led by researchers at NYU Grossman School of Medicine, the new investigation provides what they say is the first evidence that tissue damage prompts astrocytes to produce two kinds of fats, long-chain saturated free fatty acids and phosphatidylcholines. These fats then trigger cell death in damaged neurons, the electrically active cells that send messages throughout nerve tissue. Publishing Oct. 6 in the journal Nature, the study also showed that when researchers blocked fatty acid formation in mice, 75 percent of neurons survived compared with 10 percent when the fatty acids were allowed to form. The researchers' earlier work showed that brain cells continued to function when shielded from astrocyte attacks.  "Our findings show that the toxic fatty acids produced by astrocytes play a critical role in brain cell death and provide a promising new target for treating, and perhaps even preventing, many neurodegenerative diseases," says study co-senior author Shane Liddelow, Ph.D. Liddelow, an assistant professor in the Department of Neuroscience and Physiology at NYU Langone Health, adds that targeting these fats instead of the cells that produce them may be a safer approach to treating neurodegenerative diseasesbecause astrocytes feed nerve cells and clear away their waste. Stopping them from working altogether could interfere with healthy brain function. Although it remains unclear why astrocytes produce these toxins, it is possible they evolved to destroy damaged cells before they can harm their neighbors, says Liddelow. He notes that while healthy cells are not harmed by the toxins, neurons become susceptible to the damaging effects when they are injured, mutated, or infected by prions, the contagious, misfolded proteins that play a major role in mad cow disease and similar illnesses. Perhaps in chronic diseases like dementia, this otherwise helpful process goes off track and becomes a problem, the study authors say. For the investigation, researchers analyzed the molecules released by astrocytes collected from rodents. They also genetically engineered some groups of mice to prevent the normal production of the toxic fats and looked to see whether neuron death occurred after an acute injury. "Our results provide what is likely the most detailed molecular map to date of how tissue damage leads to brain cell death, enabling researchers to better understand why neurons die in all kinds of diseases," says Liddelow, also an assistant professor in the Department of Ophthalmology at NYU Langone. Liddelow cautions that while the findings are promising, the genetic techniques used to block the enzyme that produces toxic fatty acids in mice are not ready for use in humans. As a result, the researchers next plan is to explore safe and effective ways to interfere with the release of the toxins in human patients. Liddelow and his colleagues had previously shown these neurotoxic astrocytes in the brains of patients with Parkinson's, Huntington's disease, and multiple sclerosis, among other diseases.   Clinical trial for nicotinamide riboside: Vitamin safely boosts levels of important cell metabolite linked to multiple health benefits University of Iowa Health Care, October 3, 2021   In the first controlled clinical trial of nicotinamide riboside (NR), a newly discovered form of Vitamin B3, researchers have shown that the compound is safe for humans and increases levels of a cell metabolite that is critical for cellular energy production and protection against stress and DNA damage.   Studies in mice have shown that boosting the levels of this cell metabolite -- known as NAD+ -- can produce multiple health benefits, including resistance to weight gain, improved control of blood sugar and cholesterol, reduced nerve damage, and longer lifespan. Levels of NAD+ diminish with age, and it has been suggested that loss of this metabolite may play a role in age-related health decline.   These findings in animal studies have spurred people to take commercially available NR supplements designed to boost NAD+. However, these over-the-counter supplements have not undergone clinical trials to see if they work in people.   The new research, reported in the journal Nature Communications, was led by Charles Brenner, PhD, professor and Roy J. Carver Chair of Biochemistry at the University of Iowa Carver College of Medicine in collaboration with colleagues at Queens University Belfast and ChromaDex Corp. (NASDAQ: CDXC), which supplied the NR used in the trial. Brenner is a consultant for ChromaDex. He also is co-founder and Chief Scientific Adviser of ProHealthspan, which sells NR supplements under the trade name Tru NIAGEN®.   The human trial involved six men and six women, all healthy. Each participant received single oral doses of 100 mg, 300 mg, or 1,000 mg of NR in a different sequence with a seven-day gap between doses. After each dose, blood and urine samples were collected and analyzed by Brenner's lab to measure various NAD+ metabolites in a process called metabolomics. The trial showed that the NR vitamin increased NAD+ metabolism by amounts directly related to the dose, and there were no serious side effects with any of the doses.   "This trial shows that oral NR safely boosts human NAD+ metabolism," Brenner says. "We are excited because everything we are learning from animal systems indicates that the effectiveness of NR depends on preserving and/or boosting NAD+ and related compounds in the face of metabolic stresses. Because the levels of supplementation in mice that produce beneficial effects are achievable in people, it appears than health benefits of NR will be translatable to humans safely."   The next step will be to study the effect of longer duration NR supplementation on NAD+ metabolism in healthy adults, but Brenner also has plans to test the effects of NR in people with diseases and health conditions, including elevated cholesterol, obesity and diabetes, and people at risk for chemotherapeutic peripheral neuropathy.   Prior to the formal clinical trial, Brenner conducted a pilot human study -- on himself. In 2004, he had discovered that NR is a natural product found in milk and that there is pathway to convert NR to NAD+ in people. More than a decade of research on NR metabolic pathways and health effects in mice and rats had convinced him that NR supplementation had real promise to improve human health and wellness. After consulting with UI's institutional review board, he conducted an experiment in which he took 1 gram of NR once a day for seven days, and his team analyzed blood and urine samples using mass spectrometry. The experiment showed that Brenner's blood NAD+ increased by about 2.7 times. In addition, though he reported immediate sensitivity to flushing with the related compound niacin, he did not experience any side effects taking NR.   The biggest surprise from his metabolomic analysis was an increase in a metabolite called NAAD, which was multiplied by 45 times, from trace levels to amounts in the micromolar range that were easily detectable.   "While this was unexpected, I thought it might be useful," Brenner says. "NAD+ is an abundant metabolite and it is sometimes hard to see the needle move on levels of abundant metabolites. But when you can look at a low-abundance metabolite that goes from undetectable to easily detectable, there is a great signal to noise ratio, meaning that NAAD levels could be a useful biomarker for tracking increases in NAD+ in human trials."   Brenner notes this was a case of bidirectional translational science; having learned something from the initial human experiment, his team was able to return to laboratory mice to explore the unexpected NAAD finding in more detail.   Brenner's mouse study showed that NAAD is formed from NR and confirmed that NAAD levels are a strong biomarker for increased NAD+ metabolism. The experiments also revealed more detail about NAD+ metabolic pathways.   In particular, the researchers compared the ability of all three NAD+ precursor vitamins -- NR, niacin, and nicotinamide -- to boost NAD+ metabolism and stimulate the activity of certain enzymes, which have been linked to longevity and healthbenefits. The study showed for the first time that oral NR is superior to nicotinamide, which is better than niacin in terms of the total amount of NAD+ produced at an equivalent dose. NR was also the best of the three in stimulating the activity of sirtuin enzymes. However, in this case, NR was the best at stimulating sirtuin-like activities, followed by niacin, followed by nicotinamide.   The information from the mouse study subsequently helped Brenner's team design the formal clinical trial. In addition to showing that NR boosts NAD+ in humans without adverse effects, the trial confirmed that NAAD is a highly sensitive biomarker of NAD+ supplementation in people.   "Now that we have demonstrated safety in this small clinical trial, we are in a position to find out if the health benefits that we have seen in animals can be reproduced in people," says Brenner, who also is co-director of the Obesity Research and Education Initiative, professor of internal medicine, and a member of the Fraternal Order of Eagles Diabetes Research Center at the UI.   Protecting the ozone layer is delivering vast health benefits Montreal Protocol will spare Americans from 443 million skin cancer cases National Center for Atmospheric Research, October 7, 2021 An international agreement to protect the ozone layer is expected to prevent 443 million cases of skin cancer and 63 million cataract cases for people born in the United States through the end of this century, according to new research. The research team, by scientists at the National Center for Atmospheric Research (NCAR), ICF Consulting, and U.S. Environmental Protection Agency (EPA), focused on the far-reaching impacts of a landmark 1987 treaty known as the Montreal Protocol and later amendments that substantially strengthened it. The agreement phased out the use of chemicals such as chlorofluorocarbons (CFCs) that destroy ozone in the stratosphere. Stratospheric ozone shields the planet from harmful levels of the Sun's ultraviolet (UV) radiation, protecting life on Earth. To measure the long-term effects of the Montreal Protocol, the scientists developed a computer modeling approach that enabled them to look to both the past and the future by simulating the treaty's impact on Americans born between 1890 and 2100. The modeling revealed the treaty's effect on stratospheric ozone, the associated reductions in ultraviolet radiation, and the resulting health benefits.  In addition to the number of skin cancer and cataract cases that were avoided, the study also showed that the treaty, as most recently amended, will prevent approximately 2.3 million skin cancer deaths in the U.S. “It's very encouraging,” said NCAR scientist Julia Lee-Taylor, a co-author of the study. “It shows that, given the will, the nations of the world can come together to solve global environmental problems.” The study, funded by the EPA, was published in ACS Earth and Space Chemistry. NCAR is sponsored by the National Science Foundation. Mounting concerns over the ozone layer Scientists in the 1970s began highlighting the threat to the ozone layer when they found that CFCs, used as refrigerants and in other applications, release chlorine atoms in the stratosphere that set off chemical reactions that destroy ozone. Concerns mounted the following decade with the discovery of an Antarctic ozone hole. The loss of stratospheric ozone would be catastrophic, as high levels of UV radiation have been linked to certain types of skin cancer, cataracts, and immunological disorders. The ozone layer also protects terrestrial and aquatic ecosystems, as well as agriculture. Policy makers responded to the threat with the 1987 Montreal Protocol on Substances that Deplete the Ozone Layer, in which nations agreed to curtail the use of certain ozone-destroying substances. Subsequent amendments strengthened the treaty by expanding the list of ozone-destroying substances (such as halons and hydrochlorofluorocarbons, or HCFCs) and accelerating the timeline for phasing out their use. The amendments were based on Input from the scientific community, including a number of NCAR scientists, that were summarized in quadrennial Ozone Assessment reports. To quantify the impacts of the treaty, the research team built a model known as the Atmospheric and Health Effects Framework. This model, which draws on various data sources about ozone, public health, and population demographics, consists of five computational steps. These simulate past and future emissions of ozone-destroying substances, the impacts of those substances on stratospheric ozone, the resulting changes in ground-level UV radiation, the U.S. population's exposure to UV radiation, and the incidence and mortality of health effects resulting from the exposure. The results showed UV radiation levels returning to 1980 levels by the mid-2040s under the amended treaty. In contrast, UV levels would have continued to increase throughout this century if the treaty had not been amended, and they would have soared far higher without any treaty at all.  Even with the amendments, the simulations show excess cases of cataracts and various types of skin cancer beginning to occur with the onset of ozone depletion and peaking decades later as the population exposed to the highest UV levels ages. Those born between 1900 and 2040 experience heightened cases of skin cancer and cataracts, with the worst health outcomes affecting those born between about 1950 and 2000. However, the health impacts would have been far more severe without the treaty, with cases of skin cancer and cataracts rising at an increasingly rapid rate through the century.  “We peeled away from disaster,” Lee-Taylor said. “What is eye popping is what would have happened by the end of this century if not for the Montreal Protocol. By 2080, the amount of UV has tripled. After that, our calculations for the health impacts start to break down because we're getting so far into conditions that have never been seen before.” The research team also found that more than half the treaty's health benefits could be traced to the later amendments rather than the original 1987 Montreal Protocol. Overall, the treaty prevented more than 99% of potential health impacts that would have otherwise occurred from ozone destruction. This showed the importance of the treaty's flexibility in adjusting to evolving scientific knowledge, the authors said. The researchers focused on the U.S. because of ready access to health data and population projections. Lee-Taylor said that the specific health outcomes in other countries may vary, but the overall trends would be similar. “The treaty had broad global benefits,” she said.     What is Boron? The trace mineral boron provides profound anti-cancer effects, in addition to maintaining stronger bones. Life Extension, September 2021 Boron is a trace mineral found in the earth's crust and in water. Its importance in human health has been underestimated. Boron has been shown to have actions against specific types of malignancies, such as: Cervical cancer: The country Turkey has an extremely low incidence of cervical cancer, and scientists partially attribute this to its boron-rich soil.1 When comparing women who live in boron-rich regions versus boron-poor regions of Turkey, not a single woman living in the boron-rich regions had any indication of cervical cancer.2(The mean dietary intake of boron for women in this group was 8.41 mg/day.)  Boron interferes with the life cycle of the human papillomavirus (HPV), which is a contributing factor in approximately 95% of all cervical cancers.1  Considering that HPV viruses are increasingly implicated in head and neck cancers,3,4 supplementation with this ultra-low-cost mineral could have significant benefits in protecting against this malignancy that is increasing in prevalence. Lung cancer: A study conducted at the University of Texas MD Anderson Cancer Center between 1995 and 2005 found that increased boron intake was associated with a lower risk of lung cancer in postmenopausal women who were taking hormone replacement therapy. Prostate cancer: Studies point to boron's ability to inhibit the growth and spread of prostate cancer cells.  In one study, when mice were exposed to boric acid, their tumors shrank by as much as 38%.6 One analysis found that increased dietary boron intake was associated with a decreased risk of prostate cancer.7 Several human and animal studies have confirmed the important connection between boron and bone health. Boron prevents calcium loss,8 while also alleviating the bone problems associated with magnesium and vitamin D deficiency.9 All of these nutrients help maintain bone density. A study in female rats revealed the harmful effects a deficiency in boron has on bones, including:10 Decreased bone volume fraction, a measure of bone strength, Decreased thickness of the bone's spongy inner layer, and Decreased maximum force needed to break the femur. And in a study of post-menopausal women, supplementation with3 mg of boron per day prevented calcium loss and bone demineralization by reducing urinary excretion of both calcium and magnesium.8 In addition to its bone and anti-cancer benefits, there are nine additional reasons boron is an important trace mineral vital for health and longevity. It has been shown to:1 Greatly improve wound healing, Beneficially impact the body's use of estrogen, testosterone, and vitamin D, Boost magnesium absorption, Reduce levels of inflammatory biomarkers, such as high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor α (TNF-α), Raise levels of antioxidant enzymes, such as superoxide dismutase (SOD), catalase, and glutathione peroxidase, Protect against pesticide-induced oxidative stress and heavy-metal toxicity, Improve the brain's electrical activity, which may explain its benefits for cognitive performance, and short-term memory in the elderly, Influence the formation and activity of key biomolecules, such as S-adenosyl methionine (SAM-e) and nicotinamide adenine dinucleotide (NAD+), and Potentially help ameliorate the adverse effects of traditional chemotherapeutic agents. Because the amount of boron varies in the soil, based on geographical location, obtaining enough boron through diet alone can be difficult. Supplementing with low-cost boron is an effective way to maintain adequate levels of this overlooked micronutrient.

Obvinení vyšetrovatelia NAKA budú pokračovať vo svojej práci. Oznámil to dnes dočasne poverený policajný prezident Štefan Hamran. Zároveň ohlásil veľké policajné čistky a polícia podľa neho potrebuje očistu - tá spočíva v odpolitizovaní a odstránení nominantov. Vyriešia personálne zmeny situáciu v polícii? Pýtali sme sa bývalého funkcionára NAKA Petra Chudého.  A na slová šéfa polície sme sa pozreli aj so šéfkou Nadácie Zastavme korupciou Zuzanou Petkovou. V Česku dnes začali parlamentné voľby. Bez ohľadu na výsledky, problémom ešte môže byť český prezident. Miloš Zeman má totiž problém s poverením zostaviť vládu v prípade, ak by voľby vyhrala koaličná strana. Politológ Jiří Pehe ale tvrdí, že aj na Zemana majú politici páky. Moderuje Denisa Hopková. Spolupracoval Branislav Dobšinský.

If you want to work towards success, you need to start living a life that's indistractable.  We know we need to be focused. Yet, how many times a day do you get distracted from doing your most important work? It's easy to get sucked into hours of scrolling through social media or mindlessly skipping channels. These external triggers often take the blame when we get distracted. However, did you know that a more dangerous form of distraction is one where we think we're being productive? The secret is that the opposite of distraction isn't focus: it's traction. Behavioural designer Nir Eyal joins us to talk about how to form good habits and break bad ones. He discusses the four steps to becoming indistractable and staying on top of your goals. We also learn how to change our mindsets around self-limiting beliefs and pessimistic thoughts. Finally, Nir shares his expertise in creating effective habit-forming products and building an engaged community.   You have the power to become indistractable. Tune in if you want to know about how to create a distraction-free life!  Here are three reasons why you should listen to the full episode: Discover the four steps you need to take to become indistractable. Understand the true meaning of distractions and why we need to let go of limiting beliefs.  Learn how to make habit-forming products and services along with a strong community engagement. Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron!  Harness the power of NAD and NMN for anti-aging and longevity with NMN Bio.  A new program, BOOSTCAMP, is coming this September at Peak Wellness!  Listen to other Pushing the Limits episodes with Dr Elena Seranova:  #183: Sirtuin and NAD Supplements for Longevity  #189: Understanding Autophagy and Increasing Your Longevity   Connect with Nir: Website I Twitter I LinkedIn Books by Nir:  Hooked: How to Build Habit-Forming Products Indistractable: How to Control Your Attention and Choose Your Life Steven Kotler and The Flow Collective Mindset by Carol Dweck Factfulness by Hans Rosling Peter Diamandis and his books Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/. Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, Run Longer  Without Burnout & Injuries Have you struggled to fit in training in your busy life? Maybe you don't know where to start, or perhaps you have done a few races but keep having motivation or injury troubles? Do you want to beat last year's time or finish at the front of the pack? Want to run your first 5-km or run a 100-miler? ​​Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle?  Go to www.runninghotcoaching.com for our online run training coaching. Health Optimisation and Life Coaching If you are struggling with a health issue and need people who look outside the square and are connected to some of the greatest science and health minds in the world, then reach out to us at support@lisatamati.com, we can jump on a call to see if we are a good fit for you. If you have a big challenge ahead, are dealing with adversity, or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, then contact us at support@lisatamati.com. Order My Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again. Despite their words, I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books. Lisa's Anti-Ageing and Longevity Supplements  NMN: Nicotinamide Mononucleotide, an NAD+ precursor Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, is being dramatically decreased over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. Founded by scientists, NMN Bio offers supplements of the highest purity and rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful, third party tested, NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of aging while designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health My  ‘Fierce' Sports Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection. Episode Highlights [04:57] Nir's Background As a behavioural designer, Nir helps companies build products and services that encourage individuals to develop healthy habits. The same strategy and technology addictive platforms like Facebook use can help people form good habits.  Nir has written Hooked to help people build good habits. Meanwhile, Indistractable teaches people how to break bad habits. People often know what to do to create a better life but don't take action. As such, Nir believes that learning to be indistractable is the skill of the century. [06:25] On Indistractable: Understanding Distractions The opposite of distraction isn't focus; it's traction.  Traction is any action that will bring you closer to your goals and values.  Therefore, distraction is any action that will pull you away from your goals and values.  The most dangerous form of distraction is the one where we think we're being productive.  We often prioritise the urgent and easy work over the hard and important ones.  [10:40] Social Media and Addiction There's a widespread belief that social media will make you addicted. But in reality, this is learned helplessness.  When people believe that they're addicted, they often don't do anything about it.  There's nothing wrong with social media. The problem is how we use it.  We are not powerless against technology.  [13:22] How to Gain Back Control People don't accomplish a goal because they quit early and don't feel like doing the work. We often blame our distractions on external forces. However, around 90% of these are due to internal triggers.  Internal triggers are uncomfortable emotions that we want to escape. We do this by distracting ourselves.  In reality, time management is about pain management.  [17:43] Letting Go of Limiting Beliefs Nir warns against anchoring our autonomy on neurotransmitters. When we believe we have a specific nature, we limit our agency. Before labelling yourself a certain way, do the work.  People find success when they act before they make excuses.  Believing in ego depletion is also harmful. Find out why in the full episode!  [24:49] The Indistractable Model: Steps One and Two The first strategy to becoming indistractable is mastering your internal triggers through visualisation.  Don't envision the outcome. Doing so can be harmful because it makes you feel like you've already done the work.  Visualise what you'll do when you're tempted to go off track. The second step is to make time for traction. You can't call something a distraction unless you know what you're distracted from.  Having a to-do list can be harmful; plan daily schedules instead.  [27:44] The Indistractable Model: Steps Three and Four The third step is to decrease external triggers.  Finally, prevent distractions with pacts or pre-commitments.  [30:40] What You Should Measure  We have a lot of self-limiting beliefs. You need to distinguish whether these are things you cannot do or just ones you don't want to do.  When doing something, the consistency of your actions contributes more to your success than the intensity.  Understand that accomplishing your goals takes time.  Instead of looking at your output, learn to measure your progress through your inputs, such as time and effort.    [37:57] Be Willing to Put in the Hard Work  There's no magic pill for our problems and goals. Everything takes time and work.  Keep showing up and doing the hard work.  We now have access to so much information; you just need to get out there and learn.  Remember that if you're looking for distraction, it will come.  [41:58] Adapting to Changes Around Us All new things have consequences. The good thing is, we humans are highly adaptable. In the same vein, you have the power to adapt and control how you consume ‘addictive' social media. Not the other way around.  Nir believes that the world is getting better. However, good news does not get much media coverage.  Try to be more optimistic. Only then can you seek solutions to problems and not resign yourself to the situation. You don't need to worry about everyone's problems. Your human capital is best directed toward issues where you can make the easiest and most significant impact. [50:48] How to Make Habit-Forming Products Use habit-forming products frequently and soon. It should be something that you use within a week or less.  First, tap into internal triggers and specify which uncomfortable emotion your product wants to solve.  Second, reduce friction. Make your product as easy as possible to use.  Third, create variable rewards. Uncertainty is what excites people and gets them hooked. Finally, it helps to make people invest in the experience. Listen to the full episode to dive deeper into making habit-forming products!   [55:19] The 3 C's of Engagement Fostering engagement can be done through content, community, and conversation.  Curate content that will give value to others.  Empower people to help one another so you can create a strong-knit community.  Lastly, have conversations with people to share knowledge and wisdom.  7 Powerful Quotes from This Episode ‘The opposite of distraction is not focus. If you look at the origin of the word, the opposite of distraction is traction. You'll notice that both traction and distraction end in the same six letters, a-c-t-i-o-n.' ‘Traction, by definition, is any action that pulls you towards what you said you were going to do. Things that you do with intent. Things that move you closer to your values and help you become the kind of person you want to become.' ‘We have this model in our heads: traction, distraction, internal, external, right? Now we know that the four big parts of the Indistractable model. So now, we work our way around these four steps like the points on a compass.' ‘One of my life mantras is: “Consistency over intensity”. I think that's how we change.'  ‘We want that instant relief. We want that instant solution. Look, the things that are worth having in life, they take time.' ‘What's going to lead us out of our problems is not running away from these problems, not throwing up our hands and giving up. But rather, engaging with these problems, right?' ‘[Habit-forming products] appreciate in value, meaning they get better and better the more we interact with them because of what I call stored value.' About Nir Nir Eyal writes, consults, and teaches about the intersection of psychology, technology, and business. He helps companies create behaviours that benefit the users and educates people on building healthful habits in their lives. Nir previously taught as a Lecturer in Marketing at the Stanford Graduate School of Business and the Hasso Plattner Institute of Design. He is the bestselling author of Hooked: How to Build Habit-Forming Products and Indistractable: How to Control Your Attention and Choose Your Life. He also shares his insights with his newsletter at Nir and Far and has written for Psychology Today, The Atlantic, TechCrunch, and the Harvard Business Review.  Nir is also an active investor in habit-forming technologies, such as Eventbrite, Kahoot!, and Anchor.fm.  Interested in learning more about Nir's work? You check out his website. You can also reach him on Twitter and LinkedIn.        Enjoyed This Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so that they can learn what it takes to form good habits and become indistractable.  Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa

W Libanie trwa kryzys, który według Banku Światowego jest jednym z najgorszych od połowy XIX wieku. Wartość libańskiego funta w ostatnich latach spadła nawet o 90% co sprawiło, że przeciętny Libańczyk ma trudności z dostępem do jedzenia, wody, usług medycznych i lekarstw. Na te problemy nakłada się kryzys energetyczny. Kraj importuje całość swojego paliwa, ale przez niską wartość funta dystrybutorzy nie są w stanie zapewnić nieprzerwanych dostaw. A wielu Libańczyków zależnych jest od agregatów prądotwórczych napędzanych olejem napędowym. W sukurs Libańczykom przychodzi Hezbollah, który w porozumieniu z Iranem zapewnia dostawy ropy, która trafić ma do szpitali, prywatnych przedsiębiorstw a nawet domów. Czy to poprawi sytuacje w kraju? Jak do tej inicjatywy odnosi się nowy rząd budowany przez miliardera Nadżiba Mikatiego? Co w Libanie chce ugrać Iran? O tym rozmawiamy z Marcinem Krzyżanowskim, ekspertem do spraw Iranu.  29 września w czarnomorskim kurorcie Soczi doszło do spotkania prezydenta Erdogana z rosyjskim prezydentem Władimirem Putinem. Turecki przywódca zapowiadał, że będzie się podczas niego starał zacieśnić stosunki Ankary z Moskwą, a także omówić bieżąca sytuację i kolejne kroki działań tych dwóch krajów w Syrii. Czy Ankara, zgodnie ze swoimi obietnicami, zakupi kolejne rosyjskie systemy obronne S-400? Z jaką reakcją międzynarodową będzie musiała się w związku z tym liczyć? Czy Turcja jest rozczarowana szeroko rozumianym Zachodem i Sojuszem Północnoatlantyckim?  O tym rozmawiamy z doktorem Karolem Wasilewskim z Polskiego Instytutu Spraw Międzynarodowych.  24 września w Irbilu, stolicy irackiego Kurdystanu, odbyła się konferencja, na której 300 przywódców kurdyjskich i sunnickich wezwało, by Bagdad przyłączył się do tzw. porozumień abrahamowych normalizujących relacje z Izraelem. W ciągu ostatniego roku swoje stosunki z państwem żydowskim unormowały Zjednoczone Emiraty Arabskie, Bahrajn, Maroko i Sudan, ku niezadowoleniu Palestyńczyków, którzy czują się porzuceni przez arabskich partnerów. Czy Irak chce i może poprawić stosunki z Izraelem? Dlaczego oba kraje jeszcze tego nie dokonały? O tym opowiada nam Krzysztof Płomiński, były ambasador RP w Iraku.

Neopodstatnené väznenie a možno aj trestné stíhanie a obvinenie. Takto vidí bratislavský krajský súd počínanie policajnej inšpekcie, bratislavského okresného prokurátora aj sudcu, ktorí obvinili a poslali do väzby štyroch vyšetrovateľov NAKA a zastupujúceho šéfa Inšpekcie. Čo to vlastne znamená? A môže v prípade vyšetrovateľov ešte zasiahnuť aj generálny prokurátor Žilinka, a tak ako pri Pčolinskom, či Haščákovi, využiť paragraf 363? Mal by sa teraz napríklad Boris Kollár ospravedlniť za svoje výroky o Čurilovskej mafii? Braňo Závodský sa rozprával s advokátom vyšetrovateľov NAKA Petrom Kubinom a Xéniou Makarovou z Nadácie Zastavme korupciu.

Welcome to the Siim Land podcast I'm your host Siim Land and our guest today is Dr. Elena Seranova. Elena has a Ph.D. in Stem Cell Biology and Autophagy from the University of Birmingham. She also has an MSc in Translational Neuroscience and is the founder of NMN Bio. In this episode we talk about the details of the process of autophagy and how does it work. Timestamps: How Elena Became an Autophagy Researcher 01:05 What Is Autophagy 04:00 Why Is Autophagy Important 06:25 When Is Autophagy Not Good 11:11 What Activates Autophagy 12:12 How to Measure Autophagy 16:50 NAD+ Role in Autophagy 26:55 What Increases NAD+ Levels 30:20 Negative Effects of NAD+ 31:35 NAD and Aging 36:35 Best Ways to Activate Autophagy 41:21 Melatonin and Autophagy 45:10 Trehalose and Autophagy 46:30 And much more Self Decode is a genetics decoding company. You can get personalized health recommendations based on your DNA and the latest scientific research. They have numerous different DNA reports for different areas of focus like weight loss, longevity, gastrointestinal health, cognition, and even mood. Recently Self Decode came out with their 2.0 software that incorporates artificial intelligence in generating DNA reports. It's the most advanced and comprehensive consumer DNA service in the world. You can get a 10% discount with the code SIIM at get.selfdecode.com/siim Head over to get.selfdecode.com/siim and use the code SIIM for a 10% discount on your personalized DNA reports. Here are the links to the podcast on all platforms Link to the Audio Podcast on iTunes and Stitcher Link to the podcast on Spotify Link to the podcast on CastBox Watch the Biohacking Bootcamp Videos on Patreon This episode is sponsored by BiOptimizers. They're giving the listeners of this podcast an exclusive offer on one of their best-selling products. It's called Magnesium Breakthrough and is the most full-spectrum magnesium supplement out there. Most supplements contain only 1 or 2 forms of magnesium... when in reality there are at least 7 that your body needs and benefits from. Magnesium is the master mineral that governs virtually all physiological processes in the body.  With volume discounts combined with our custom 10% coupon code, SIIM10, you can save up to 40% off select packages of Magnesium Breakthrough! That's an AMAZING value. And I promise that deal is ONLY available on this specific website,  Click Here to Support the Show on Patreon!   Show Notes Elena Seranova Twitter NMN Bio Website Lucas Aoun's Natural Testosterone Optimization Course 10% OFF The Immunity Fix on Amazon Get Magnesium Breakthrough for a 10% Discount! Use Code SIIM for 10% Off Self Decode Use Code SIIM for a 10% Discount on the KAATSU Bands My New Book Stronger by Stress My NEW BOOK Metabolic Autophagy Metabolic Autophagy Audiobook Metabolic Autophagy Master Class Total Sleep Optimization Video Course Get the FULL GUIDE to INTERMITTENT FASTING FREE BOOK Get the Metabolic Autophagy Program Keto Adaptation Manual Book Watch the Biohacking Bootcamp Videos on Patreon Body Mind Empowerment Handbook Keto Fit Program Keto // IF Program Stay Empowered Siim          

Calling all health nerds, biohackers and beauty aficionados! In this fascinating episode, leading functional medicine expert Dr. Will Cole, sits down with Dr. Charles Brenner, a research pioneer in the area of nicotinamide adenine dinucleotide (NAD+). NAD+ is fundamental to the creation of energy in every cell of your body.  NAD+ regulates pivotal cellular processes that are key to looking and feeling our best. Getting your NAD+ levels optimized can help you maintain vibrant energy levels and that youthful glow. Tune in to learn the exciting science behind NAD+ and discover why it is so vitally important to the cellular health of our bodies. Listen in as Dr. Brenner discusses the best ways to boost your NAD+ levels naturally. Learn more: www.drwillcole.com/podcast   Redefine aging today by visiting Tru Niagen    Produced by Dear Media

A big question that anti-aging pragmatists, holistic health practitioners, and biohackers ask is...What is the safest, most effective, and most practical way to supplement NAD+?NAD+ itself is not orally bioavailable, if you want to supplement it directly you need to get it injected intravenously, right in your bloodstream. Which is pricey (about $600) and needs to be done in a NAD clinic by a professional. Fortunately, there are several other ways to supplement NAD+ that are a lot more practical and economical.

As the saying goes, trust your gut — and this isn't only figuratively. One of the most overlooked aspects of health is our digestive system. We tend to ignore and underestimate the symptoms we experience around our gut. But with its link to our brains, our guts play a much more significant role in our overall health. The simple act of eating healthy foods can completely turn your life around. Kirsty Wirth joins us in this episode to share how reexamining gut health impacted her and her son's life. She talks about the road to recovery, specifically her family undergoing fecal microbial transplant (FMT). Kirsty highlights the importance of in-depth gut health testing, cutting out junk foods, and consuming healthy foods. She further discusses the two types of fermented food and how we can incorporate it into our diet. If you're having trouble with your digestive system and want to know which healthy foods to choose, this episode is for you.    Here are three reasons why you should listen to the full episode: Learn how an undiagnosed gut issue can lead to an autism spectrum misdiagnosis. Discover the importance of eating healthy foods when looking after your microbiome. Find out the two types of fermented food and their effects on the body.   Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron!  Harness the power of NAD and NMN for anti-aging and longevity with NMN Bio.  A new program, BOOSTCAMP, is coming this September at Peak Wellness!  Listen to my other Pushing the Limits episodes:  #170: The Search for the Perfect Protein and Why So Many of Us Are Deficient with Dr David Minkoff #183: Sirtuins and NAD Supplements for Longevity with Dr Elena Seranova #189: Understanding Autophagy and Increasing Your Longevity with Dr Elena Seranova Connect with Kirsty: Instagram I Facebook I Email  Kultured Wellness Get your Kultured Wellness starter culture here! Join a Kultured Wellness Programme today! Kulturing Kuriosity podcast Lifespan: Why We Age – and Why We Don't Have To by Dr David Sinclair   Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/.   Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, Run Longer  Without Burnout & Injuries Have you struggled to fit in training in your busy life? Maybe you don't know where to start, or perhaps you have done a few races but keep having motivation or injury troubles? Do you want to beat last year's time or finish at the front of the pack? Want to run your first 5-km or run a 100-miler? ​​Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle?  Go to www.runninghotcoaching.com for our online run training coaching.   Health Optimisation and Life Coaching If you are struggling with a health issue and need people who look outside the square and are connected to some of the greatest science and health minds in the world, then reach out to us at support@lisatamati.com, we can jump on a call to see if we are a good fit for you. If you have a big challenge ahead, are dealing with adversity, or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, then contact us at support@lisatamati.com.   Order My Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again, but I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books.   Lisa's Anti-Ageing and Longevity Supplements  NMN: Nicotinamide Mononucleotide, an NAD+ precursor Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, is being dramatically decreased over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. Founded by scientists, NMN Bio offers supplements of the highest purity and rigorously tested by an independent, third-party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful, third-party tested, NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of aging while designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health   My  ‘Fierce' Sports Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection.   Episode Highlights [04:55] The Story Behind Kultured Wellness Kirsty started Kultured Wellness because of her personal experience and what her son went through.  She started having tummy upsets from age two onwards. She would constantly swing between constipation and diarrhea.  Acquiring viral encephalitis at age 13 and being hospitalised for a week was a landmark time in Kirsty's life. Gut problems became a constant issue from then on. Her husband, who is a nurse, told her constant diarrhea is not normal. So, she dabbled with various diets but didn't stick with them. It's not until they found out about her son's conditions that Kirsty took concrete action. [09:55] Kirsty's Son's Autism Spectrum Diagnosis At 13 months, Noah suffered from infections and tummy troubles. Fortunately, his recovery progressed well. But at 18 months, Noah became completely non-verbal, underwent behavioural changes, and suffered from constant diarrhea. The paediatrician said that Noah's condition was normal. However, his condition only worsened.  Then, Noah was diagnosed with autism. This gave them funding for treatment and support. [13:56] Discovery of an Underlying Gut Issue The possibility that Kirsty passed on her diarrhea issue to Noah was always at the back of her mind. They found a doctor who listened to their suspicion that Noah has an underlying condition.  After testing Noah's stool sample, they discovered that he had Clostridium difficile, a type of antibiotic-resistant bacteria. This bacteria releases endotoxin that compromises the gut and the blood-brain barrier. They found that the endotoxin in Noah's body had attached to the brain receptors responsible for socialisation and learning. [17:21] Undergoing Fecal Microbial Transplant (FMT) Kirsty and her two children participated in a research study in Canada. There, they underwent a fecal microbial transplant. Their guts were flushed with antibiotics to get rid of everything, including the Clostridium difficile. These were then replaced with donors' microbes.  Kirsty's children were the youngest people to undergo FMT. While they were there, Noah started becoming more sociable. Not everyone needs to undergo FMT to recover their gut. There are now many ways to modulate the gut, one of which is eating healthy foods. Tune in to the full episode to hear more about Noah's recovery and development as a teen! [25:42] Getting Diagnosed with PANDAS PANDAS is an autoimmune neurological condition associated with an antigen. Both Kirsty and Noah got diagnosed with it. It stands for Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections. Listen to the full podcast to learn more about PANDAS and how Kirsty acquired it! [33:13] Looking After Your Microbiome Test, don't guess. Get a comprehensive stool analysis. Kirsty uses two tests for her clients. You need to be intentional in choosing healthy foods. Include fermented and nourishing food for your gut. Also, remember that diets do not work. No amount of willpower can go against our primal built-in set point. [46:10] Two Types of Fermented Food and Their Effect on the Body The first is the wild type. This includes histamine-forming foods or lactate-forming metabolites. Our gut has microbes that consume histamine and help us not develop histamine issues. The second is uncultured ferment. These are specific ferments in a controlled environment with specifically chosen strains. People struggling with lactate-forming metabolites should choose D-lactate bacteria strains.  These strains break down and down-regulate histamines without causing reactions. [48:50] Incorporating Fermented Healthy Foods into Your Diet You can start with small amounts of uncultured ferment to build out your microbiome.  Then, you can start dabbling with wild ferments. Kirsty develops cultures with nine different strains that have efficacy for autoimmune, neurological, and digestive conditions. Kultured Wellness offers a starter culture that you make yourself. Listen to the full episode to know the ingredients and the procedure! [53:05] On Probiotics and Digestive Enzymes One capsule of probiotics in the market has around 3 million CFU or colony-forming units.  Meanwhile, a cup of Kultured Wellness yoghurt has 41 billion CFU. The absence of digestive enzymes and stomach acid is a major problem today. Fermented food helps with this problem because it has already been pre-digested from the fermenting process.  Fermented food doesn't require a robust amount of digestive enzymes. In fact, it supports the excretion of stomach acid. [57:06] Parting Advice  Be curious and try your best to connect with your body. You're in a state of fight or flight all the time when you're unwell. We should not be focusing on DNA; it's the microbes that affect our DNA. Being curious, taking responsibility, owning it, and wanting more for yourself is crucial.   7 Powerful Quotes ‘I have seen how important your gut is and how it can completely change the pathway of your life. It can completely change who you are as a person.' ‘You don't just suddenly wake up one day and you've got cognition issues; that's coming from somewhere.' ‘So the first thing is just test, don't guess... We [can] really find out what is happening in our gut, and we can find out what it is doing to the rest of our body.' ‘If you want to make change, you've got to front up to make the change.' ‘If they don't include fermented foods and they don't include nourishing foods for their gut, they're relying on willpower. No one can get anywhere with willpower.' ‘It's what everyone finds hard and doesn't know, is that you should never rely on willpower. Diets will never work.' ‘DNA is not what we should be focusing on. It's actually the microbes and those fungi and viruses that make up our whole body that actually interacts through that.'   About Kirsty Kirsty Wirth is the founder of Kultured Wellness and an expert in cultures, gut health, and probiotics. Kultured Wellness is a company dedicated to providing knowledge and healthy foods for optimum gut health. As an integrative health coach, Kirsty's area of interest is in how lifestyle, environment, and diet can impact gut health and the immune system. Drawing on her background and years of research, Kirsty educates people on the root cause behind underlying conditions. Her mission is to spread the word about the benefits of healthy foods, particularly fermented food in nourishing the gut's microbiome. If you want to learn more about Kultured Wellness, you may visit their website. You can reach out to Kirsty on Instagram and Facebook. You can also send her an email at mailto:info@kulturedwellness.com.     Enjoyed This Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can be inspired to eat healthy foods for their gut health.  Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa  

Australia's decision to cancel its French submarine contract in favour of partnering with the US and the UK on nuclear-powered boats has provoked local and international controversy. The decision has implications for US, Chinese, European and Southeast Asian diplomacy and defence policies. Richard McGregor, the Lowy Institute's Senior Fellow for East Asia, talks with three experts: Bilahari Kausikan, the former head of the Singapore Foreign Ministry, Yun Sun, of the Stimson Centre in Washington DC, and Nadège Rolland, of the National Bureau of Asia Research in the United States.

Nadège est avec un homme depuis 7 ans. Ce dernier cloisonne toute sa vie. A tel point qu'après tout ce temps, Nadège n'existe pas pour la famille de cet homme. Bien qu'il reconnaisse qu'ils n'ont rien à voir ensemble et qu'il n'a pas un comportement élégant avec Nadège, il n'arrive pas à la quitter. Nadège aussi a essayé, en vain. Chaque soir, en direct Caroline Dublanche accueille les auditeurs pour 2h30 d'échanges et de confidences. Pour participer, contactez l'émission au 09 69 39 10 11 (prix d'un appel local) ou sur parlonsnous@rtl.fr .

Health optimisation often involves a good diet, sleep, and exercise. But do we know how to implement practices that are compatible with our bodies? For some people, intense exercise can lead to more oxidative stress and inflammation! Not only that, some of us take medication and pills to treat pain and hormones, but are these really helping?   Small actions today can lead to big problems in the future.     Kashif Khan from The DNA Company joins us in this episode to talk about how understanding our DNA can help us make better choices for our health. Diseases can be prevented with healthy habits. But before you try any DNA testing, you should understand the nuances within the genetic industry. With Kashif's advice, you can learn to choose a provider that can help you take actionable steps. If you want to know more about the science behind DNA testing for health optimisation, then this episode is for you!   Get Customised Guidance for Your Genetic Make-Up For our epigenetics health programme, all about optimising your fitness, lifestyle, nutrition and mind performance to your particular genes, go to  https://www.lisatamati.com/page/epigenetics-and-health-coaching/.   Customised Online Coaching for Runners CUSTOMISED RUN COACHING PLANS — How to Run Faster, Be Stronger, Run Longer  Without Burnout & Injuries Have you struggled to fit in training in your busy life? Maybe you don't know where to start, or perhaps you have done a few races but keep having motivation or injury troubles? Do you want to beat last year's time or finish at the front of the pack? Want to run your first 5-km or run a 100-miler? ​​Do you want a holistic programme that is personalised & customised to your ability, goals, and lifestyle?  Go to www.runninghotcoaching.com for our online run training coaching.   Health Optimisation and Life Coaching If you are struggling with a health issue and need people who look outside the square and are connected to some of the greatest science and health minds in the world, then reach out to us at support@lisatamati.com, we can jump on a call to see if we are a good fit for you. If you have a big challenge ahead, are dealing with adversity, or want to take your performance to the next level and want to learn how to increase your mental toughness, emotional resilience, foundational health, and more, then contact us at support@lisatamati.com.   Order My Books My latest book Relentless chronicles the inspiring journey about how my mother and I defied the odds after an aneurysm left my mum Isobel with massive brain damage at age 74. The medical professionals told me there was absolutely no hope of any quality of life again, but I used every mindset tool, years of research and incredible tenacity to prove them wrong and bring my mother back to full health within three years. Get your copy here: https://shop.lisatamati.com/collections/books/products/relentless. For my other two best-selling books Running Hot and Running to Extremes, chronicling my ultrarunning adventures and expeditions all around the world, go to https://shop.lisatamati.com/collections/books.   Lisa's Anti-Ageing and Longevity Supplements  NMN: Nicotinamide Mononucleotide, an NAD+ precursor Feel Healthier and Younger* Researchers have found that Nicotinamide Adenine Dinucleotide or NAD+, a master regulator of metabolism and a molecule essential for the functionality of all human cells, is being dramatically decreased over time. What is NMN? NMN Bio offers a cutting edge Vitamin B3 derivative named NMN (beta Nicotinamide Mononucleotide) that can boost the levels of NAD+ in muscle tissue and liver. Take charge of your energy levels, focus, metabolism and overall health so you can live a happy, fulfilling life. Founded by scientists, NMN Bio offers supplements of the highest purity and rigorously tested by an independent, third party lab. Start your cellular rejuvenation journey today. Support Your Healthy Ageing We offer powerful, third party tested, NAD+ boosting supplements so you can start your healthy ageing journey today. Shop now: https://nmnbio.nz/collections/all NMN (beta Nicotinamide Mononucleotide) 250mg | 30 capsules NMN (beta Nicotinamide Mononucleotide) 500mg | 30 capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 250mg | 30 Capsules 6 Bottles | NMN (beta Nicotinamide Mononucleotide) 500mg | 30 Capsules Quality You Can Trust — NMN Our premium range of anti-ageing nutraceuticals (supplements that combine Mother Nature with cutting edge science) combats the effects of aging while designed to boost NAD+ levels. Manufactured in an ISO9001 certified facility Boost Your NAD+ Levels — Healthy Ageing: Redefined Cellular Health Energy & Focus Bone Density Skin Elasticity DNA Repair Cardiovascular Health Brain Health  Metabolic Health   My  ‘Fierce' Sports Jewellery Collection For my gorgeous and inspiring sports jewellery collection, 'Fierce', go to https://shop.lisatamati.com/collections/lisa-tamati-bespoke-jewellery-collection.   Here are three reasons why you should listen to the full episode: Discover how our bodies are a whole system of processes and how our genes can be affected by many factors such as lifestyle and behaviour. Learn the differences in DNA testing companies and how you can get the best value out of your reports. Understand how to boost your immunity and prevent diseases!      Resources Gain exclusive access and bonuses to Pushing the Limits Podcast by becoming a patron!  Harness the power of NAD and NMN for anti-aging and longevity with NMN Bio.  A new program, BoostCamp, is coming this September at Peak Wellness! Past episodes with Dr Mansoor Mohammed: Episode 181 - Understanding Your Genetic Hormone Pathways Episode 160 - Understanding Your Own DNA   Connect with Kashif: LinkedIn I Twitter I Facebook      Know how you can change your lifestyle based on your genes. Learn more on The DNA Company.  Tiny Habits by Dr. BJ Fogg Books by Peter Diamandis and Steven Kotler The Future Is Faster Than You Think  Bold Abundance    Episode Highlights [04:09] Understanding What Your DNA Means Every process in your body is being driven by genetic instructions. Kashif's company set out to make these instructions more actionable for their clients. You can do a quick online search of ‘DNA testing near me' and get many hits, but you won't get the results you want out of these. Many of our diseases are preventable; consistently making the wrong choices can lead us to develop these illnesses.     Those choices will not be the same for everyone. You can look at your genetics to see what the right choices are for you.  [08:11] Know What You're Testing For Most companies offering DNA testing tend to make conclusions based on a single gene. However, the body is more complex than that.  Many of these DNA tests don't really dive deep into your health. To make their business model profitable, many businesses in the genetic industry sell their patient's data to pharmaceutical companies. The genetic industry has been used as a data collection machine. Kashif's vision for their company is to turn this situation around and derive key insights for their consumers.  [12:35] The Role of Hormones in Health  Kashif observes that their company has had the biggest impact on women's healthcare.  This is due to the massive gap between what women need and what is provided by traditional healthcare.  There is a widespread belief that women are supposed to have hormone-related issues like PMS. However, this should not be the case. Tune in to the full episode to find out how Kashif helped pinpoint his niece's hormone issues using DNA testing and analysis. [19:26] Covering Up the Symptoms The healthcare industry tends to look at a problem in isolation and try to treat it with medication.  Treating hormonal issues is not as simplistic as prescribing pills for the hormones a patient lacks. Listen to the full episode to hear more insights on this topic! For instance, we're led to believe that women are prone to breast cancer when they reach menopause. However, this condition is preventable.      [24:01] Applying AI to DNA Testing Kashif's company found it challenging to train clinicians to interpret results from DNA testing.  To remedy this problem, they are using AI technology to create personalised reports and recommendations.  As a result, their reports are now much more comprehensive. It even analyses your mood and behaviour—crucial factors when it comes to dealing with your health. [30:05] Understanding Your Mood and Behaviour   Lisa's high adrenaline and lack of dopamine receptors manifest in an action-oriented behaviour.  Kashif shares that having low dopamine receptors can also lead to addiction or depression. That's because you are predisposed to not experience reward and pleasure.  Curious to know how your genes affect your mood? Find out how DNA testing can shed a light on this in the full episode!  You can view your gene expressions two-fold: a weakness and a superpower. For instance, you may think that you are irritable. But that also makes you detail-oriented. [35:50] Change Takes Effort Kashif's company is focused on solving and preventing problems.  People may get great recommendations, but the real challenge lies in implementation and change.  Community and accountability are important to help people stay on track. Group accountability with people in similar situations can increase motivation and persistence.  [42:21] Prevention is the Key The current healthcare system is based on a reactive model rather than a preventive one.  Diseases can be prevented; we don't need to reach a point of crisis until we take action.  In the US, the Center for Disease Control created a Diabetes Prevention Program, the first of its kind in the country.  [47:31] Health at the Cellular Level Diseases are born from inflammation, which is based on cellular health. Cellular health depends on the body's capacity for detoxification and oxidative stress.  Simple activities like golfing can have long term effects. Kashif shares that golfers may be in danger of inhaling pesticides in golf courses.  Exercise may work for some people. However, people with weaker SOD2 are prone to oxidative stress and more toxicity in the blood.  Your genetics will dictate what kind and how much exercise you should do. Listen to the full episode to learn more! [56:34] The Future of Healthcare  Beyond DNA testing and analysis, it's important to have someone knowledgeable on your end. They can help patients get the most value out of the reports. New technologies tend to go through different phases. These involve deception, disruption, dematerialisation, demonetisation, and democratisation.  The technology in the genetic industry is becoming more accessible. It is now near the latter phases of technology development.    7 Powerful Quotes ‘We didn't go study DNA. There's enough science out there already. We studied people. We said, “Let's start at what's wrong with this person? What are they expressing as a symptom? Let's drill down genetically to see where is the system failing.”' ‘Of all the things we do, female hormone health is where we had the biggest impact. Not because we're the greatest, but because it's the worst experience in current healthcare.' ‘The DNA world looks at things in terms of disease. So you can speak at it that way. But there's so much more to it than that if you know how to interpret it.' ‘We believe coaching is primarily around accountability. So we have coaches we train that understand the reports, that can help.' ‘We're all coming out of the same model, I suppose this reactive healthcare model. Really, we're inventing the future of healthcare.‘ ‘That's only then when you have that persistence and the resilience to actually go through with these changes that you're actually going to get new results.' ‘This reactive system that we're living in at the moment and the current model is just bloody bandaids on festering wounds.'   About Kashif Kashif Khan is the founder and CEO of The DNA Company, a functional genomics company. They help people understand their unique genetic code and how to unlock their physical potential. If you're looking for ‘DNA testing near me', their company is the one to call. They ensure actionable advice through a comprehensive genomic profile.  Kashif is also the co-founder and CEO of Younutrients. Their company provides supplement formulations personalised to people's unique needs. In addition, he is also an investor and serial entrepreneur. He has helped build, scale, and run several businesses across different industries. He has advised early-stage startups and Fortune 500 companies including the Royal Bank of Canada and Cirque du Soleil.  Interested in Kashif's work? Check out The DNA Company.  You can also reach out to Kashif on LinkedIn, Twitter, and Facebook.          Enjoyed This Podcast? If you did, be sure to subscribe and share it with your friends! Post a review and share it! If you enjoyed tuning in, then leave us a review. You can also share this with your family and friends so they can be inspired to search for ‘DNA testing near me' and optimise their health.  Have any questions? You can contact me through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts. To pushing the limits, Lisa

Pro Fighter Elias “The Spartan” Theodorou joins The Eben Flow for a deep dive into cannabis as medicine for athletes. Elias is the only professional athlete to have successfully obtained a Therapeutic Use Exemption (TUE) for cannabis. In this episode we discuss how he (and a roundtable of medical professionals) navigated numerous flaming hoops, USADA, and other institutional regulatories in order to achieve this groundbreaking agreement. We also break down the fundamentals of “performance enhancing drugs”, question the advice of “experts” and muse on NFT's. Enjoy!For more from this Legend follow Elias on Instagram: @eliastheodorouAnd, on twitter: @eliastheodorou Join The Power Tribe on Patreon! This Sunday, September 26, 2021 @12pm PST LIVE Group Breath Work and Yoga session! Would love to see you there. For BONUS Eben Flow content: Breath Work, Guided Meditations, Yoga, 1-on-1 Coaching! Head over to: www.patreon.com/edsbritton Check out an exclusive offer for my listeners from biOptimizers! Just go to www.bloodsugarbreakthrough.health/ebenflow and use the code Ebenflow10 to save 10 percent when you try Blood Sugar Breakthrough.October 7-9, 2021 in Austin, Texas I am joining Joe DiStefano at his epic event The Gathering by Runga Life! This is a WORLD CLASS Wellness Immersion. Breath Work, Meditation, Hyperbaric Chambers, Vitamin IV's, NAD+, Ice Tubs, Epic Workouts & MORE! Check it all out at www.rungalife.com/the-gathering Get bonus content on Patreon See acast.com/privacy for privacy and opt-out information.

In paranoid times like these, I'm relieved that I've been invested in my immunity defense for the past 25 years. I'm sharing everything I did to cure myself of the big C that's (still) got everyone up in arms (and we all thought this would only last two weeks!). I'm continuing my health protocol, which I lay out in the episode. Pretty much everything I mention is linked (and there are a couple of exclusive discounts in there for you too). I invite you to listen, do your research, and equip your body as YOU choose. The last time I checked, that was still a human right.   Viruses aside, I also dig into other ponderings from the community, giving my insights into biohacking, mercury lightbulbs, circumcision, and so much more.    02:59 —Vincent asks: I'm looking to build a biohacking lab and researching various PEMF, mats, and scalar wave devices. Would love recommendations from this community on what biofeedback devices I should consider adding to my lab. Higher Dose infrared mat (large and small)  The RASHA - listen to ep 309: The RASHA: Quantum Space Travel: The Key to Consciousness Expansion W/ Dr. Jere Rivera Dugenio The Biocharger - listen to ep.195: BioCharger: Harnessing the Healing Power of The Cosmos AmpCoil - listen to ep 98: Ampcoil: The Power of Biofeedback + PEMF for Lyme Autoimmune W/ Aaron Geneva Bigalow EMF protection with Blu Shield, Somavedic and FLFE  Magnetico Mattress Pads for under beds (use code luke10 Nuerocoustic sound therapy with the VIBE Bed and Nucalm- listen to ep.322: Good Vibrations: Bioharmonics and Sound Healing W/Dr Vibe Feat. Dr. Steven Schwartz  And ep. 265: Maximum Meditation W/ NuCalm: The Ultimate Stress Relief System w/ Jim Poole  Brain Tap Nanovi - Think of it like an inhalable antioxidant I use the Lucia Light (use code lukestorey10) for a completely natural psychedelic-Esque journey An absolute non-negotiable for me is ice baths. I have Morozko Forge Ice Bath (use code luke150 or luke500). Listen to ep.351: Chill Out: The Ice Bath Revolution W/ Morozko Forge's Jason Stauffer and Adrienne Jezick Sauna Space single person sauna (use code luke5) and Clearlight multi-person sauna (mention luke) Red-light therapy. I use Joovv Red Light Therapy. Listen to ep.169 The Biohacking Superpowers of Red Light Therapy W/ JOOVV OxyHealth Hyperbaric Oxygen Chamber (use code luke)  07:40 — Barbara and Natalie ask: Can you advise on natural ways to heal spider bites and repel mosquitos? The anti-infection and anti-inflammatory properties in Ozonated oil from global healing (use code LUKESTOREY) Hista-Aid from Quicksilver Scientific, for the histamine reaction to the bite Since moving to Texas, I've been using Allicin, a garlic extract. I take one cap in the morning, one in the evening.  Bug Block from American Botanical Pharmacy is the strongest natural product on the market I've found.    10:00 — Rex asks: If circumcision is a “satanic ritual” are colonoscopies also?  Ep. 308: Ending Infant Trauma:  Dangers of Hospital Birth, Ultrasound Circumcision W/ Jeanice Barcelo Ep192: ​​The War Against Boys: Ending Torture of Circumcision in America  Watch: American Circumcision  Gravity colonics to eliminate toxins Colon cleansing using calcium bentonite clay and activated charcoal.    15:25 — Lincoln asks: When you use a Defender Shield product, what is the external battery I should plug my phone into so I avoid EMF?  Defender Shield for phone Any large capacity phone battery will work, but this is the one I use  Avoid using your phone and computer device when plugged in as they produce more EMF   18:46 —Christine asks: Is there still mercury in incandescent bulbs?  Be careful with CFL bulbs and fluorescent tubes because of the blue and flickering light  Why fluorescent and LED bulbs are bad for the environment and your health   21:55 —Bailey asks: Do you feel that doing good things with the intent of getting back goodwill, in fact, brings bad karma? How selfless acts for others helped me during my recovery Savoring acts of generosity for yourself   28:15 — The community asks: How do I deal with viral infections, building immunity, and protect myself from spike proteins? I get asked these questions a lot and have covered the topic in-depth with various experts. Listen to ep. 304: Don't Fear The Virus: Your Body's Immunity and Humanity's Awakening W/ Dr. Zach Bush Ep. 276: Plandemic Power Play: Challenging The Media Big Pharma Virus Narrative w/ Dr. Rashid Buttar  Ep. 299: Shot In the Dark: Blowing the Whistle On the Vacc!ne Industry + Cov!d W/ Robert F Kennedy Jr Ep. 273: Solving the Wuhan 5G Covid-19 Mystery W/ Dr. Thomas Cowan Check out what I have to say on my current views on the plandemic, lockdowns, quack scenes, and spike protein shedding on my telegram channel at lukestorey.com/telegram  Free tools require willpower and nothing else. Prayer, faith, meditation, human touch and connection, mindfulness, breathwork, sunlight, hot and cold exposure, sleep hygiene, light gazing, movement  Steps I took to cure my virus last year Rectal and ear canal ozone therapy with Longevity Resources. Ozone injections are also a good idea. Glutathione and high dose vitamin C. I used Mitozen glutathione, high-dose melatonin, and NAD suppositories. Listen to ep. 367: Not Just For Sleep: Melatonin | The Master Molecule + Next Level Biohacks w/ Dr. John Lieurance Quantum energy devices such as FLFE, Leela Infinity Bloc and Somavedic  Hyperbaric oxygen chamber treatments for immunity, blood flow, and oxygen saturation of the blood plasma. I have the Oxyhealth Vitearis 300 which was a big investment but you can rent them now.   Colon cleansing with oxy powder from Global Healing for detox Oregano oil by North American Herb and Spice for anti-viral and anti-bacterial.  Resistor ozonated oil capsules for gut health, mitochondrial function, and immunity  Ultimate igg from Just Thrive Quercetin from global healing for immune and respiratory response Pure Encapsulations Calcium D-glucarate for detox  Raw dandelion leaf to protect from spike proteins  C-60 from Purple Power for systemic inflammation reduction “The One” by Quicksilver Scientific QQ and CO-Q-10 from which is a product they call ' the one'. Both are incredible for mitochondria, which is where we get ATP energy to fight illness and recover quickly.  Infrared saunas. Sauna Space for infrared light therapy benefits and Clearlight for its relaxed, group-friendly setting.  HigherDOSE infrared mat for immunity Naked sun time for immunity and vitamin D production Biocharger and AmpCoil immunity and anti-infection programs. Zinc and Boron from Upgraded Formulas. They do mail order testing to check what you're deficient in.  Quicksilver Scientific liposomal d3/k2  High dose reishi mushroom extract from Longevity Power for immunity and nervous system balance.  High dose systemic enzymes from Bioptimizers to prevent blood clotting. Serrapeptase enzyme is also great for clotting and breaking down spike proteins. Schizandra berry extract from Surthrival for its high shikimate content, which breaks down spike proteins. As does fennel, star anise tea, pine oil (Aka Hinoka Blood Purifier.) (stock up at Shen Blossom) Methylene blue from Troscriptions for antiviral properties Patrick Flannagins MegaHydrate, a super-powerful anti-oxidant  NAC ( N-Acetylcysteine ) helps you produce glutathione. It just got banned from the FDA so stock up!  Activated charcoal from Quicksilver Scientific's “Ultra Binder” (activated charcoal). Shilajit for minerals. PristineHydro makes a great powder.   Molecular hydrogen tablets from Water and Wellness  and Vital Reaction 7% inhaler  for antioxidant/inflammation reduction   1:02:16 — Caleb asks: My family is getting together all the items for nebulizing peroxide for lung infections (Dr. David Brownstein). Do you know of any high-quality Lugol's iodine?” I use the Unoseks portable nebulizer] American Biotech Labs Silver Biotics Immune System Support Iodine from Upgraded Formulas  Glutestat by MitoZen I'm intrigued by Hydroxychloroquine and  Ivermectin, although I have not taken them personally myself. Please be aware, that these are only available by prescription.       More about this episode. Watch it on YouTube. Connect with Luke on social media to learn how to take your lifestyle to the next level, plus catch exclusive live interviews & events: INSTAGRAM - @lukestorey // instagram.com/lukestorey/ FACEBOOK - facebook.com/MrLukeStorey/ TWITTER - @MrLukeStorey // twitter.com/MRLUKESTOREY YOUTUBE - youtube.com/c/LukeStorey   THIS SHOW IS BROUGHT TO YOU BY: MAGNESIUM BREAKTHROUGH. According to the American Psychological Association, chronic stress is linked to the six leading causes of death. When most people think of stress, they think of their job, traffic, tense relationships, current events, things like that. But the root of so much of the stress we experience comes down to a deficiency in one overlooked nutrient — magnesium. So, if you're ready to help your body deal with stress, instead of putting a band-aid on it after the fact, you're going to want some Magnesium Breakthrough. You can use the code “luke10” for 10% off at www.bioptimizers.com/luke   AND... Eaton Hemp - The CBD industry is all about trust, and with so many brands out there just slapping labels on products it is important to know where your products come from. I love Eaton Hemp because they're transparent about where everything comes from–an organic farm in upstate NY where you get the goodness of clean soil. Head to eatonhemp.com and use the code: “LUKE” for 20% off all products.    AND…   BodyBio PC  Lays a foundation for health by addressing the health of your cells and your cell membrane. With a unique full-spectrum phospholipid complex with all the phospholipids that make up the cell membrane (PC, PS, PE, PI). It heals and repairs our cell membrane from the damage that toxins have caused, enabling better brain function, cognition, memory, liver support, microbiome support, and skin health. Go to BodyBio.com and use the code “luke20 “for 20% off all products HELP SUPPORT THIS SHOW! Love the Show? You'll really love Luke's Master Market Online Store!  It's a win-win! Get direct links to all of Luke's hand-picked biohacking and health products all in one place, exclusive discounts, and support the show by making purchases through the web store >> SHOP NOW.   Other ways to support:  SUBSCRIBE >> Apple Podcasts + Stitcher + Google Podcasts + Spotify LEAVE APPLE PODCASTS REVIEW >> Simple step-by-step instructions SHARE >> Spread the word! Tell your family, friends, neighbors, and all your social pals   Resources Join me on Telegram for the uncensored content big tech won't allow me to post. It's free speech and free content: www.lukestorey.com/telegram

NAD stands for Nicotinamide Adenine Nucleotide. It is essential to the creation of energy in the body and coordinating cellular processes. It's a critical coenzyme found in every cell in your body. Tom Ingoglia's life changed when he was infected with Lyme disease because he experienced adverse drug reactions that spiraled into drug addiction. But his rock bottom was losing half his family in the same week. Tom dedicated himself to healing over eight years, found intravenous NAD⁺ therapy, and miraculously regained his health. He went on to spearhead IV NAD therapies in the clinic he created.   ------------------------ If you're looking to improve your hair wellness and get thicker, stronger and longer hair, make sure to check out https://fullyvital.com ------------------------ Topics of Discussion: - How Did Tom Find NAD? - Why Is NAD So Important For Anti-Aging and Health? - What Happens To NAD Levels As We Get Older - How Is NAD Made In the Body? - How Can You Get NAD From External Sources - Who Are The NAD Pioneers? - What's Tom's Involvement with NAD - Where to Get Some NAD Patches That You Can Try Out (use discount code FARAZ15) Check out the detailed show notes at https://antiaginghacks.net/nad

Nourish your body from the inside out to live a long, happy, and healthy life. Dr. Anna breaks down the science behind longevity and explores the key supplements to promote health and reduce inflammation, how to reduce and avoid the toxins and endocrine disruptors we face everyday in our lives, and why love is the best medicine of all. [0:15] Longevity begins in the womb. What we do for our health matters for generations. In the past episode Dr. Anna talked about a number of different treatments that were meant to help maintain a pregnancy, but instead resulted in a plethora of negative effects generations down the line. [1:05] There are age reversal techniques that everyone can do that can have tremendous genetic and generational positive benefits. [1:40] The healthier we are as a community and with our relationships the longer we live with a high quality of life. Love, laugh, and give is a great mindset to start your day and end your life with. [3:50] Treatments can have generational effects. Endocrine disruptors like Diethylstilbestrol (DES) were touted as a wonderful, universal drug for pregnant mothers but resulted in numerous negative effects. [4:50] Dr. Anna recently attended the Da Vinci 50 conference and Dr. Gregory Church recommended that the FDA should require third generational animal studies before releasing a medication out to the public. Most medications today do not meet that standard. [6:30] Protect yourself from toxic overload and hormone disruptors. In many places, disruptors can even be found in tap water. [7:30] Another key area that affects our longevity is our epigenetics. If you don't have your 23andMe health yet, it can be a good idea to get it. Knowing how well you methylate will determine the best types of supplementation for you. [8:40] You also need to pay attention to toxin exposure. Things like fireproof treated fabric can be absorbed through the skin, and particular GMOs can cause issues. [10:05] Anything with PCBs is considered highly toxic. Dioxin, a byproduct from chloride containment processes, can linger in the environment for years and diminishes the production of thyroid hormones. [10:50] A recent patient came to Dr. Anna with low testosterone. Before dealing with the symptom, it's important to address the cause of the problem. Her approach was to do an endocrine toxicity screen and address the thyroid issues. [12:40] If you're suffering from low testosterone, we have to ask where the testosterone is going. Is it being converted to estrogen? Is it becoming dihydrotestosterone? These could result in either man boobs or hair loss, so it's important to understand what is going on. [13:55] Most of us haven't been aware of the potent complication of endocrine disruptors. We are seeing an overall increase of infertility, early menopause, and early andropause. [14:20] Phthalates are very common in the plastic drinking bottles we use. Avoiding BPAs is also important, which are found in plastics as well as metal food containers. The rule of thumb is to reduce our exposure to toxins as much as possible. [17:30] Off-Gassing of chemicals can also occur in your shower curtain and dry cleaning bag. Switching to a natural fiber shower curtain is an easy, quick fix. [18:00] Even something as innocuous as the receipts you get at the store have BPAs on them. Cashiers should think seriously about using gloves while handling receipts all day. [19:10] Seek out products that have the FDA-certified Organic label. The reverse should be the norm, where foods are labeled as grown with pesticides, but that's the reality we live in. [20:55] Heavy metals are major endocrine disruptors. Mercury from fish, and lead in air pollution, all impact fertility and cause complications in pregnancy. Dr. Anna often tests patients for heavy metals and recommends natural chelators. Vitamin C and certain foods like garlic, ginger, broccoli sprouts, and more help reduce toxic heavy metals in the body. [27:00] Chromosome maintenance and repair will improve all the downstream symptoms. Telomere erosion and genetic errors age us rapidly. Natural aging can be accelerated through life and environmental stresses like smoking, high blood sugar, high blood pressure, and inflammation. [27:50] Inflammation accelerates aging universally, from your hair to your skin to your brain cells. Mitochondria are the powerhouses of the cell, and when they are functioning poorly for a number of different reasons, it leads to rapidly declining energy and fatigue. [29:15] Anyone with autoimmune issues is affected by rapid aging. The lower your basal metabolic rate, the more unhealthy you are. [30:30] Glucose regulation is the number one recommendation from experts in longevity. Keeping your glucose levels steady throughout the day with a diet like Keto Green will certainly help. Especially for women going through menopause, a stable blood sugar and a habit of fasting can drastically improve the quality of your life. [34:10] Sticking with the Keto Green lifestyle leads to more benefits the longer you persist. [34:40] Maintaining a stable glucose level and avoiding the peaks and valleys of snacking and card heavy meals throughout the day is a true hack for longevity. [34:55] If you're a poor methylator because of your genetics, you will age faster if you don't intervene. [36:20] We live in a climate-controlled world, and exposing yourself to extreme temperatures can have a major positive impact on your metabolism. Cold plunges have been used for thousands of years to improve performance. [37:10] Supplements can also promote longevity. Things like turmeric, green tea extract, and resveratrol increase antioxidants in the body and promote healthy aging. [39:10] DHEA levels are something you should also try to keep high. Supporting the adrenal gland can help your body produce its own DHEA and keep your levels in the optimal range. [40:35] MNM is a precursor to NAD, a powerful anti-inflammatory and supports the mitochondria. [41:25] Dr. Anna breaks down her daily supplementation regimen which can be found in her Super Woman packs. [45:15] Another supplement mentioned during the conference is spermidine. Certain exercises can help you increase your flow of this natural longevity-promoting substance. [46:40] Stem cell injections have also shown anti-aging effects. As more science is produced supporting those results, the more likely it will be the future of anti-aging treatment. [48:10] If we have an unhealthy gut, we are unhealthy. Keeping the gut as healthy as possible is crucial to hormone balance and longevity. [48:25] Gratitude, meditation, being out in nature, and getting a good night's sleep are all components of a long, healthy lifestyle. [49:25] Most of the time, it's the things we say no to that make the most difference in your life. [49:50] Love is the best medicine. Love, laugh, and give is the mantra that Dr. Anna lives by and recommends others to do as well.       Mentioned in this Episode: youtube.com/thegirlfrienddoctor dranna.com/show     Always seek the advice of your own physician or qualified health professional before starting any treatment or plans. Information found here and results are provided for informational purposes only and are not intended to replace a one-on-one relationship with a qualified healthcare professional and are not intended as medical advice.

If you thought melatonin was just for sleeping and getting a solid tan, think again. I had the pleasure of getting the intel on the miracle of melatonin from Dr. John Lieurance, who uses this natural substance and extensive scientific research to create MitoZen, a curated portfolio of suppositories, nasal sprays, and CBD products that enhance the absorption of nutrients in the body. I have a stash that gets me through the day and salvages my brain and body turning to pulp during my travels.  We discuss the melatonin health benefits you've never heard about, how to combat low melatonin levels, why it should be a priority, and why the delivery of nutrients is crucial to its efficacy. Plus: how MitoZen helped him integrate his plant medicine journeys on the 3D plane. Get ready to be floored by Dr. John Lieurance's knowledge, scientific background, and mind-blowing product, MitoZen, which you can try at a discount when you head to mitozen.com/luke.  05:50 —Dr. John Lieurance's Pain-to-Purpose Journey  The concept of his practice and How a personal wrist injury led to him discovering diagnostic ultrasounds    18:45 — The MitoZen Origin Story  The health benefits of rapé, the Amazonian tobacco  Creating ritual and intentionality for health routines My first rapé experience in Costa Rica How MitoZen supports the parasympathetic nervous system Why oxytocin is in the ZEN spray  Why suppositories are better than IVs    09:15 — Melatonin 101  Melatonin and autism Melatonin as the ultimate stress protector Aerobic glycolysis: the inefficient way of making energy  Take a melatonin deep dive: melatoninbook.com Why your suntan is a reflection of your internal health  Building up melatonin with astaxanthin and chaga tea Why melatonin decreases with age  The effects of taking high dose melatonin Using melatonin during the day Ozone therapy (check out episode #350 with Ian Mitchell)  Detoxing heavy metals with melatonin  EMF and melatonin  The travel hacker kit that saves me from jetlag   01:34:05 — Melatonin Biohacks How to decalcify the pineal gland Fasting and NAD  Glutathione suppository for virus and brain protection  How MitoZen helped him integrate a plant experience  Ketamine, body work, and healing (check out episode #335 with Dr. Joy Kong) Functional cranial release therapy  Michael Rice and Joe Dispenza's influences and teachings  More about this episode. Watch it on YouTube. Connect with Luke on social media to learn how to take your lifestyle to the next level, plus catch exclusive live interviews & events: INSTAGRAM - @lukestorey // instagram.com/lukestorey/ FACEBOOK - facebook.com/MrLukeStorey/ TWITTER - @MrLukeStorey // twitter.com/MRLUKESTOREY YOUTUBE - youtube.com/c/LukeStorey   THIS SHOW IS BROUGHT TO YOU BY: MAGNESIUM BREAKTHROUGH. If you're having trouble falling or staying asleep, one of the best things you can possibly do is start getting enough magnesium. Most magnesium supplements use only the two cheapest synthetic forms. However, Magnesium Breakthrough by BiOptimizers uses the seven unique forms of magnesium that you must get if you want to experience its calming, sleep-enhancing effects. Simply take two capsules before you go to bed and you'll be amazed by how much better you sleep. And how much more rested you feel when you wake up! You can use the code “LUKE10” at magbreakthrough.com/luke to save 10%.   AND...   WATER AND WELLNESS. I take my water very seriously and use Water and Wellness to ensure my H2O is pure, toxin-free, and mineral-rich. Their team has crafted a portfolio backed by decades of research and phenomenal results. My house is set up with their RO countertop water filter, AquaTru, and my cupboards are stocked with Quinton to keep me hydrated and healthy daily. Head to waterandwellness.com/storey and use the code “Storey10” for 10% off all products.    AND…   INSIDETRACKER. When you do what you love – like running, racing, enjoying the great outdoors – you want to do it for life. InsideTracker can help. InsideTracker was founded in 2009 by leading scientists in aging, genetics, and biometrics. Using their patented algorithm, InsideTracker analyzes your body's data to provide you with a clear picture of what's going on inside you, and to offer you science-backed recommendations for positive diet and lifestyle changes. Then InsideTracker tracks your progress every day, every step of the way toward reaching your performance goals, and toward living a longer, healthier life. You can get 25% off the entire InsideTracker store for a limited time by going to: insidetracker.com/luke.     HELP SUPPORT THIS SHOW! Love the Show? You'll really love Luke's Master Market Online Store!  It's a win-win! Get direct links to all of Luke's hand-picked biohacking and health products all in one place, exclusive discounts, and support the show by making purchases through the web store >> SHOP NOW.   Other ways to support:  SUBSCRIBE >> Apple Podcasts + Stitcher + Google Podcasts + Spotify LEAVE APPLE PODCASTS REVIEW >> Simple step-by-step instructions SHARE >> Spread the word! Tell your family, friends, neighbors, and all your social pals   Resources Website: mitozen.com/luke for a 5% discount  Join me on Telegram for the uncensored content big tech won't allow me to post. It's free speech and free content: www.lukestorey.com/telegram   Related Shows Episode #350: “The Ultimate Ozone Show: The Miracle Molecule For Radical Health Energy w/ Ian Mitchell” Episode #335: “Stem Cell Healing & Ketamine Therapy w/ Dr. Joy Kong” 

Matt Kaeberlein is globally recognized for his research on the biology of aging and is a previous guest on The Drive. In this episode, Matt defines aging, the relationship between aging, chronic inflammation, and the immune system, and talks extensively about the most exciting molecules for extending lifespan. He discusses the current state of the literature of testing rapamycin (and rapalogs) in animals and humans, including Matt's Dog Aging Project, and provides insights into how we can improve future trials by conceptualizing risk, choosing better endpoints, and working with regulators to approve such trials. He also examines the connection between aging and periodontal disease, biomarkers of aging, and epigenetic clocks. Finally, they explore some of the biological pathways involved in aging, including mTOR and its complexes, sirtuins, NAD, and NAD precursors. We discuss: The various definitions of aging [3:25]; The relationship between disease and the biology of aging [16:15]; Potential for lifespan extension when targeting diseases compared to targeting biological aging [22:45]; Rapamycin as a longevity agent and the challenges of targeting the biology of aging with molecules [32:45]; Human studies using rapalogs for enhanced immune function [39:30]; The role of inflammation in functional declines and diseases of aging [50:45]; Study showing rapalogs may improve the immune response to a vaccine [56:15]; Roadblocks to studying gero-protective molecules in humans [1:01:30]; Potential benefits of rapamycin for age-related diseases—periodontal, reproductive function, and more [1:12:15]; Debating the ideal length and frequency of rapamycin treatment for various indications like inflammation and longevity [1:21:30]; Biomarkers of aging and epigenetic clocks [1:29:15]; Prospects of a test that could calculate biological age [1:37:45]; The Dog Aging Project testing rapamycin in pet dogs [1:42:30]; The role of the mTOR complexes [1:58:30]; mTor inhibitor called Torin2, mitochondrial disease and other potential pathways [2:09:45]; Catalytic inhibitors, sirtuins, and NAD [2:19:15]; NAD precursors: help or hype? [2:28:15]; and More. Learn more: https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/MattKaeberlein2  Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.  

Drs. Dawson, Mallin and Goodman discuss the longevity benefits of fasting mimickers, including Metformin, NAD and rapamycin, plus Dr. Mallin makes a compelling case for giving NAD to your pet worms and mice. This was recorded at our spring Wild Health Summit. We'll be doing it again this fall! Sign up at wildhealthsummit.com.