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In this episode, I'm joined by board-certified dermatologist Dr. Dustin Portela to break down the skincare trends, treatments, and products that are dominating social media. We discuss what a simple, effective skincare routine should look like, the truth about peptides, growth factors, exosomes, and collagen supplements, and how to separate evidence based skincare from online hype. We also rate some of today's most viral skincare trends, including beef tallow, red light therapy, NAD, snail mucin, at home microneedling, plasma pens, and salmon DNA facials, while discussing what actually works, what's overhyped, and what may not be worth your time or money. If you've ever wondered whether the latest skincare craze lives up to the claims, this episode is for you. Topics Discussed: → What does an effective skincare routine actually look like? → Are peptides, growth factors, and exosomes worth the investment? → How do sleep, exercise, and lifestyle habits affect skin aging? → How can you spot misleading skincare advice on social media? → Which viral skincare trends actually work, and which are overhyped?
You already know something has changed - the energy crashes, the slow recovery, the brain fog that wasn't there ten years ago. Most people assume that's just aging. But it's NOT. Nobel Prize-winning research has identified a single molecule that controls how fast your body breaks down, and more importantly, exactly why yours is being destroyed faster than it's being rebuilt. The fix isn't complicated, but the order you do it in matters. In this video, Dave breaks down what this molecule is, why your body is actively working against it, and the exact protocol (diet, fasting, exercise, and supplementation) to restore it before the gap gets any wider.Thank you to our sponsors!Gatlan | Book your free consultation at www.gatlan.com/DAVEViome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:0:00 – The Longevity Switch0:47 – Why Mitochondria Matter2:28 – What Mitophagy Is2:46 – How Mitophagy Works4:18 – What Shuts It Off8:54 – The Damage Compounds9:22 – How to Turn It Back On10:31 – Signal 1: Fasting11:48 – Signal 2: Exercise (REHIT)12:30 – Signal 3: Cold Exposure13:22 – Signal 4: NAD+14:29 – Signal 5: Urolithin A and SpermidineConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
In this episode the guys break down the six best lifts for athletic fitness — the movements that translate directly to real world performance, sport and everyday life. They cover lunges and sled work, the standing overhead press, trap bar deadlift, one arm rows with rotation and pull ups, hanging leg raises done correctly, and band and cable chops for rotational power. They also reminisce about their worst business failures — Sal's second studio location that cost him 75K to break the lease, Adam's mobile car detailing hustle, Justin's app build, and Doug's story of losing his entire Japan savings to a fraudulent investment group that got raided by the IRS mid-call. Then they answer questions from Instagram on Bulgarian split squat imbalances, swapping exercises in MAPS 15 Powerlift, which program fixes imbalances and unlocks squat depth, and how to pair sprint intervals with strength training. No BS 6-Pack Formula: https://nobs6pack.comCode: 6PACK for 50% off. Full ab building system with two phase blueprints and video demos by Sal. $28.50 after discount. SPONSORS Rho Nutrition (liposomal creatine, NAD+ and Glutathione): https://www.rhonutrition.com/discount/MINDPUMP Code: MINDPUMP for 20% off everything. Liposomal creatine discussed on air as the fix for people who experience bloating from regular creatine. Paleo Valley (grass-fed fermented meat sticks): https://paleovalley.com/mindpump 15% off automatically applied at checkout, no code needed. Our Place (non-toxic cookware): https://fromourplace.comCode: MINDPUMP for 10% off sitewide. Always Pan replaces eight pieces of cookware, forever chemical free, 100 day trial with free returns. LINKS Mind Pump Store: https://mindpumpstore.comMaps Fitness Products: https://mapsfitnessproducts.com Instagram: @mindpumpmedia 0:00 - Intro 2:28 - 6 best lifts for athletic fitness 3:25 - Lunges and sled work — triple extension, split stance and why sled is the most accessible power exercise 8:09 - Standing overhead press — the squat of the upper body and how it reveals your whole body strength 10:22 - Trap bar deadlift — why athletic coaches prefer it over conventional for most sports 14:38 - One arm rows with rotation and pull ups — pulling strength and the rotational component most programs miss 16:31 - Hanging leg raises — how to do them correctly and why they matter for every athletic movement 18:25 - Band and cable chops — rotational and anti-rotational power for sport 21:15 - Worst business failures — studios, apps, car detailing and Doug's IRS raid story 50:13 - Rho liposomal creatine solving the bloating problem for women 51:43 - Justin's Yellowstone trip and the bear world grizzly feeding park 59:25 - Paleo Valley fermentation process and the Truckee cabin bear break-in story 1:01:22 - Q&A: Bulgarian split squat imbalances — how to even out a weaker leg 1:04:41 - Q&A: Swapping exercises in MAPS 15 Powerlift with weaker lift variations 1:05:47 - Q&A: Best MAPS program for fixing imbalances and unlocking squat depth 1:07:40 - Q&A: How to pair sprint intervals with strength training correctly
There are some ugly truths about the vet industry…Recorded right after The Life Stylist's 10th anniversary, in this episode, Alyson and I get into holistic pet care, fear of death, and what John Gray's research on the male prefrontal cortex explains about it.Plus: holistic pet care that won't bankrupt you, a painless NAD+ injector pen, Lumios bulbs that finally solved the LED problem, a marine collagen with pearl powder that actually dissolves, and moving beyond the fear of dying.Get the Animal Power book and deck, plus a free guided drumming shamanic journey to meet your power animal, at alysoncharles.com/animalpower.Visit lukestorey.com/zeocharge and use code LUKE for 10% offVisit lukestorey.com/myvitalc and use code STOREY for $30 off your first orderVisit ionlayer.com/luke and use code LUKE to get 20% off NAD+ patches and pensVisit lukestorey.com/raoptics and use code LUKE for 10% offVisit igniton.com/luke and use code LUKE for 15% offVisit piquelife.com/luke 15% off for life when you subscribeVisit foursigmatic.com/luke and use code LUKE for 10% offVisit lukestorey.com/lyma and use code LUKE10 for 10% off the LYMA Laser (not valid on LYMA Laser PRO)Visit solyn.com and use code LUKE for 10% offYou'll learn:[0:00] Introduction[13:48] The Sedona Airbnb closet incident and why men's brains shut down under stress[25:52] Is the vet industry designed to create lifetime customers?[50:15] Most LED lights are toxic; Lumios cracked the code on bulbs[57:17] The marine collagen with pearl powder that dissolves and tastes incredible[1:10:09] Move beyond the fear of dying and embrace death as another experience[1:23:05] Viewing the birth-death portal as a single act of creation[1:31:36] Bearing witness at my father's hospital bedside and the nobility of dying[1:54:03] If fear doesn't exist in the source field, what does that mean for our exit?Resources Mentioned:LiteWater Scientific Deuterium-Depleted Water | WebsiteBEAM Minerals Advanced Canine Mineral & Electrolyte Replenishment Set | WebsiteQuinton Marine Plasma | WebsiteENERGYbits Algae Tablets | WebsiteSaunaSpace Firelight Infrared Sauna | WebsiteLiving Silica | WebsiteAxiom H2 Super-Saturated Hydrogen Rich Water Bottle | WebsiteAlitura | WebsiteYoung Goose (Use code LUKE10 for 10% off) | WebsiteCopper GHK+ Facial Serum with Cycloastragenol (Use code STOREY10 for 10% off) | WebsiteFull show notes at lukestorey.com/674Related The Life Stylist Episodes:Relationship Expert Reveals the Secrets That Make Romance Last Forever w/ Dr. John Gray | PodcastDeuterium Depletion: The Most Powerful Health Hack You've Never Heard Of W/ Dr. Que Collins & Dr. László Boros | PodcastDemystifying The Myths & Magic of Zeolite: Detoxing Metals, Mold, & Mycotoxins Safely | PodcastGet Minerals In & Toxins Out to Power Your Mitochondria, Hormones, & Brain | PodcastAlgae Unleashed! Spirulina + Chlorella For Detox, Anti-Aging, & Max ATP Power | PodcastCircadian Light Masterclass: Debunking Sunglasses, Sunbathing & Blue-Light Hysteria w/ Matt Maruca | PodcastThis Laser Technology Will Revolutionize Skin Treatments Forever w/ Lucy Goff | PodcastHow to Die: Facing Our Death Phobia & Embracing Our Elders w/ Stephen Jenkinson | PodcastFind more from Alyson:Alyson Charles Storey | Website | Instagram | Facebook | X | TikTok | YouTubeCeremony Circle Podcast | Spotify or AppleFind more from Luke:Luke Storey | Instagram |
To read the The Rape Gang Inquiry Report To Support the work of Apologia -Our newest sponsor is Dominion Wealth Strategists! -Get the NAD treatment Jeff is on, go to Ion Layer and put “IONAPOLOGIA” into the coupon code and get $100 off your first three months! -Check out Amtac Blades and use code APOLOGIA in the check out for 5% off! -You can get in touch with Heritage Defense and use coupon code “APOLOGIA” to get your first month free! -For some Presip Blend Coffee Check out our Store. -Check out the Ezra Institute
What if aging isn't simply your body “wearing out”… but your body losing the ability to repair itself? In this episode, Dr. Andrew Salzman joins Dr. Josh Axe to explain why chronic inflammation, leaky gut, and depleted NAD may quietly drain the very energy your cells need to heal, think, move, and survive. Uncover what's really going on in your body with advanced biomarker testing for hormones, thyroid, and metabolism— plus a 1-hour consultation with a Senior Health Advisor! → http://mybloodwork.com Thank you to our sponsors! Sunlighten Sauna: https://get.sunlighten.com/axepodcast Manukora Manuka Honey: https://manukora.com/axe Caraway Home: carawayhome.com/drjoshaxe (Use code DRJOSHAXE) for an exclusive discount Watch The Dr. Josh Axe Show every Monday & Thursday on YouTube: https://www.youtube.com/@drjoshaxe?sub_confirmation=1
Most of us have heard that we need to exercise more, but today, exercise physiologist Dr Stacy Sims digs into what kind of training actually moves the needle for women — and why longer, slower workouts may be leaving results on the table. We get into the real difference between high-intensity interval training and sprint interval training, why the Norwegian 4x4 is one of the most efficient tools for building VO2 max, how to structure a full week of training across just three days, and why your wearable's heart rate zones are probably misleading you more than helping you. WHAT YOU'LL LEARN Why high-intensity and sprint interval training are not the same thing — and why the distinction matters What the Norwegian 4x4 actually is and why it's so effective for VO2 max How to combine strength, sprint, and cardio work into just three sessions a week Why resistance training and high-intensity work should be prioritised over Zone 2 if you're short on time The truth about BDNF, brain health, and why you need both a seed and the miracle grow Why wrist-worn heart rate monitors consistently fail during high-intensity efforts What Zone 2 actually is — and why most people are training too hard to be in it Why 10,000 steps is a marketing figure, not a science target Why "Zone Zero" has no basis in exercise physiology VALUABLE RESOURCES Watch the full podcast here: https://youtu.be/2SWU8_KDFmc Take the BioSyncing Quiz to help you understand what's actually happening in your body — and how to fix it.
Get ready for new taxes, Seattle. Rantz exclusive: Seattle lost 41 police officers with patrol staffing at just 868, with reason to celebrate and worry. Media is pretending that there’s no reason to suspect vandalism at Reflection Pool. // Guest: UW Professor Matt Kaeberlein discusses the health benefits of NAD+ supplements. // New York times reporter Maggie Haberman claims that the media is too easy on Trump.
Book a free consultation call with Robert Sikes to break through your keto or low carb plateau: https://www.ketobodybuilding.com/callMost supplements look good on the label and still fail where it counts: absorption, results, and real health.In episode 895 of the Savage Perspective Podcast, host Robert Sikes talks with Marc Macaluso about why bioavailability matters more than the supplement label. This edited conversation dives straight into Marc's work building a longevity supplement company and explains liposomal delivery, vitamin D, magnesium, NAD support, mushrooms, quercetin, hyaluronic acid, inflammation, thyroid health, and why many products underdeliver. They also cover blood work, manufacturing, and what honest wellness should look like for people who want better health, better energy, and a longer life.Find Marc Macaluso and TMW Longevity on Instagram at https://www.instagram.com/tmw.longevity/Learn more at https://tmwlongevity.com/Get Keto Brick: https://www.ketobrick.com/Subscribe to the podcast: https://open.spotify.com/show/42cjJssghqD01bdWBxRYEg?si=1XYKmPXmR4eKw2O9gGCEuQ
"I am your father". Darth Vader's iconic phrase that cemented itself in pop-culture history, and Vader as one of the all-time most famous father in history. However, this begs the question: who is the best father in Star Wars?Today we celebrate Father's Day and ponder that question. Are some of the dad's we'd think would be bad dads or are they actually pretty good? Who are our favorite Star Wars dads?Most importantly, we categorize everyone between Dad, Father, and Daddy (trust us, it makes sense).• • •TRIAD Of The FORCE is a STAR WARS+ podcast hosted by Gus, Nani, Nad, & Chase—Puerto Rican and queer creators sharing deep dives, and heartfelt conversations from a galaxy far, far away. Featured on the STAR WARS CELEBRATION Podcast Stage (2022 & 2023), we explore STAR WARS, fantasy, comic books, and other POP-culture media honestly. We engage in inclusive commentary across film, TV, books, comics, and beyond with humor, critical analysis, and cultural perspective (without the toxicity).Follow TRIAD Of The FORCE at:BlueSky: https://bsky.app/profile/triadoftheforce.bsky.socialInstagram: https://www.instagram.com/triadoftheforce/YouTube: https://www.youtube.com/c/TriadoftheForce/If you like us, get some merch and help the channel:TeePublic: https://www.teepublic.com/user/triad-of-the-force• • •Acknowledgement: The Intro and Outro music is the Triad of the Force Theme, composed and performed by Grushkov with full permission for use by Grushkov (https://linktr.ee/Grushkov).• • •This channel is not affiliated in any way with Lucasfilm Ltd. LLC, The Walt Disney Company, or any of their affiliates or subsidiaries.
Naděje na stabilizaci situace na Blízkém východě přinesly pokles cen ropy i zemního plynu. Podle energetického analytika Jiřího Gavora však trhy stále nevěří, že je krize zažehnána. „Situace zdaleka není dořešena. Naděje je, ale konflikt může vypuknout znovu,“ říká. Jak moc ovlivňuje energetický trh dění na Blízkém východě a co by znamenal návrat íránské ropy na světové trhy?
He carried two copies of ApoE4, the highest genetic risk factor for Alzheimer's disease, went through medical school knowing exactly what his LDL of 700 meant, decided the experts were wrong, and then published the case report to prove it. In this episode, Louisa sits down with Dr. Nick Norwitz, PhD researcher and metabolic scientist, for one of the most scientifically dense conversations on brain health, cholesterol biology, and Alzheimer's prevention ever recorded on this show. They cover why the phospholipid form of DHA reaches the brain more effectively than standard fish oil, how ApoE4 carriers burn through omega-3s differently and what to do about it, the lithium orotate data that sold out supplement shelves worldwide, and why GSK-3 beta, the enzyme that phosphorylates tau, may be the most under appreciated target in Alzheimer's research today. Then Dr. Nick Norwitz lays out the case that challenges the "LDL is always the enemy" consensus: why metabolically healthy individuals may not benefit from aggressive lipid-lowering therapy, what his viral coronary CT angiogram showed after seven years of 700+ cholesterol, why the EZPAVE trial headlines don't hold up under scrutiny, and what GLP-1s are doing inside the brain completely independent of weight loss. You'll also hear about the sardine diet experiment, the omega-3 thermogenesis connection, ketones as misfolded protein clearance agents, creatine for depression, retatrutide and PCSK9, BPC-157 risks, and what Dr. Nick Norwitz believes is coming in Alzheimer's gene therapy within the next decade. *Reduce your risk of Alzheimer's with my science-backed protocol for women 30+:*https://go.neuroathletics.com.au/youtube-sales-page Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. _____ *TOPICS DISCUSSED*(00:00:00) Intro: The ApoE4 Paradox and the Case Report That Broke the Internet (00:00:57) Why Standard Omega-3 Supplements Fail and What to Take Instead (00:05:13) DHA and the Phospholipid Carrier: How It Crosses the Blood-Brain Barrier (00:10:19) ApoE4 Explained: Risk, Genetics, and Why Nick Is Optimistic (00:17:38) Why ApoE4 Carriers Burn Through DHA Faster and Need More (00:20:31) Women, Omega-3s, Menopause, and Brain Insulin Resistance (00:21:41) Statins, Sex Differences, and the DHA-Blood Sugar Connection (00:26:01) Statins and Dementia: What the Data Actually Say (00:32:24) Tau, GSK-3 Beta, Lithium Orotate, and Targeting Alzheimer's Pathology (00:42:19) The Glymphatic System, 40Hz Devices, and Sleep as Brain Clearance (00:45:21) Gene Editing, Prime Editing, and the Future of ApoE4 Therapy (00:49:33) Nick's Case Report: 700 LDL, Zero Plaque, and Seven Years of Data (00:55:10) The EZPAVE Trial: Why the Headlines Don't Hold Up (01:00:33) KetoneIQ: Ketones for Brain Energy and Focus (01:01:29) Cheers Health: Supporting Liver Function and Cognitive Recovery (01:03:54) If Not LDL, What Causes Heart Disease in Metabolically Healthy People? (01:12:05) The Oreo Experiment and the Sardine Diet: Self-Experiments in Metabolism (01:19:10) Ketones, Women's Brains, and Clearing Misfolded Proteins (01:21:08) The Full Brain Health Protocol: Omega-3s, Creatine, NAD, Lithium, and More (01:24:01) GLP-1s for the Brain: Independent of Weight, Targeting Amyloid and Tau (01:25:28) Peptides: BPC-157 Risks, Retatrutide, MOTS-c, and What's Worth Watching (01:29:02) Why Nick Is Controversial And Why He Doesn't Mind _______ *Thank you to our sponsors*Fenix Health Science: fenixhealthscience.com Use code NEUROEXPPulsetto: https://pulsetto.tech/pages/NEURO or use Code NEURO for some off your orderFunction Health: https://www.functionhealth.com/louisanicolaBASED Bodyworks: https://basedbodyworks.com/ and use code NEURO for 20% offKetoneIQ: https://ketone.com/NEURO for 30% OFFCheers Health: https://CheersHealth.com/NEURO or use code NEURO for 20% off _______ I'm Louisa Nicola - clinical neurophysiologist - Alzheimer's prevention specialist - founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention.If you're committed to optimizing your brain- reducing Alzheimer's risk - and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0Instagram: https://www.instagram.com/louisanicola_/Twitter : https://twitter.com/louisanicola_ Learn more about your ad choices. Visit megaphone.fm/adchoices
He carried two copies of ApoE4, the highest genetic risk factor for Alzheimer's disease, went through medical school knowing exactly what his LDL of 700 meant, decided the experts were wrong, and then published the case report to prove it. In this episode, Louisa sits down with Dr. Nick Norwitz, PhD researcher and metabolic scientist, for one of the most scientifically dense conversations on brain health, cholesterol biology, and Alzheimer's prevention ever recorded on this show. They cover why the phospholipid form of DHA reaches the brain more effectively than standard fish oil, how ApoE4 carriers burn through omega-3s differently and what to do about it, the lithium orotate data that sold out supplement shelves worldwide, and why GSK-3 beta, the enzyme that phosphorylates tau, may be the most under appreciated target in Alzheimer's research today. Then Nick lays out the case that challenges the "LDL is always the enemy" consensus: why metabolically healthy individuals may not benefit from aggressive lipid-lowering therapy, what his viral coronary CT angiogram showed after seven years of 700+ cholesterol, why the EZPAVE trial headlines don't hold up under scrutiny, and what GLP-1s are doing inside the brain completely independent of weight loss. You'll also hear about the sardine diet experiment, the omega-3 thermogenesis connection, ketones as misfolded protein clearance agents, creatine for depression, retatrutide and PCSK9, BPC-157 risks, and what Nick believes is coming in Alzheimer's gene therapy within the next decade. Reduce your risk of Alzheimer's with my science-backed protocol for women 30+:https://go.neuroathletics.com.au/youtube-sales-page Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. _____ TOPICS DISCUSSED 00:00 Intro: The ApoE4 Paradox and the Case Report That Broke the Internet 00:57 Why Standard Omega-3 Supplements Fail and What to Take Instead 05:13 DHA and the Phospholipid Carrier: How It Crosses the Blood-Brain Barrier 10:19 ApoE4 Explained: Risk, Genetics, and Why Nick Is Optimistic 17:38 Why ApoE4 Carriers Burn Through DHA Faster and Need More 20:31 Women, Omega-3s, Menopause, and Brain Insulin Resistance 21:41 Statins, Sex Differences, and the DHA-Blood Sugar Connection 26:01 Statins and Dementia: What the Data Actually Say 32:24 Tau, GSK-3 Beta, Lithium Orotate, and Targeting Alzheimer's Pathology 42:19 The Glymphatic System, 40Hz Devices, and Sleep as Brain Clearance 45:21 Gene Editing, Prime Editing, and the Future of ApoE4 Therapy 49:33 Nick's Case Report: 700 LDL, Zero Plaque, and Seven Years of Data 55:10 The EZPAVE Trial: Why the Headlines Don't Hold Up 01:00:33 KetoneIQ: Ketones for Brain Energy and Focus 01:01:29 Cheers Health: Supporting Liver Function and Cognitive Recovery 01:03:54 If Not LDL, What Causes Heart Disease in Metabolically Healthy People? 01:12:05 The Oreo Experiment and the Sardine Diet: Self-Experiments in Metabolism 01:19:10 Ketones, Women's Brains, and Clearing Misfolded Proteins 01:21:08 The Full Brain Health Protocol: Omega-3s, Creatine, NAD, Lithium, and More 01:24:01 GLP-1s for the Brain: Independent of Weight, Targeting Amyloid and Tau 01:25:28 Peptides: BPC-157 Risks, Retatrutide, MOTS-c, and What's Worth Watching 01:29:02 Why Nick Is Controversial And Why He Doesn't Mind _______ Thank you to our sponsors Fenix Health Science: fenixhealthscience.com Use code NEUROEXP Pulsetto: https://pulsetto.tech/pages/NEURO or use Code NEURO for some off your order Function Health: https://www.functionhealth.com/louisanicola BASED Bodyworks: https://basedbodyworks.com/ and use code NEURO for 20% off KetoneIQ: https://ketone.com/NEURO for 30% OFF Cheers Health: https://CheersHealth.com/NEURO or use code NEURO for 20% off _______ I'm Louisa Nicola - clinical neurophysiologist - Alzheimer's prevention specialist - founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain- reducing Alzheimer's risk - and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ Learn more about your ad choices. Visit megaphone.fm/adchoices
Leveling Up: Creating Everything From Nothing with Natalie Jill
What if the supplements you've been taking to feel better are actually the reason you feel worse? That's exactly what happened to me, and it sent me down a rabbit hole that led to one of the most important conversations I've had about my own health. Today I'm sitting down with my close friend and personal doctor, Dr. Sabrina Solt, a regenerative medicine physician and peptide expert who has been in this field for over a decade. We start with the question that started everything for me: why was I wired at 3am, crashing every afternoon, and reacting to the exact supplements I thought were helping? Dr. Solt breaks down the cortisol-prolactin connection that most doctors never test for, explains why elevated cholesterol in midlife women is often a protective response rather than a red flag, and walks us through the inflammation markers that actually tell the full story of what's happening inside the body. Then we go deep on what she calls the upstream-downstream problem, the real reason why things like methylated B vitamins, NAD drips, and glutathione pushes can backfire so badly in certain women, and what to do instead. She explains the genetic piece around MTHFR and COMT variations, why "more" is rarely the answer, and what supporting downstream clearance actually looks like in practice. From there, we get into peptides. Dr. Solt gives a grounded, clinical breakdown of BPC-157, TB-500, KPV, the copper peptide GHKCU, growth hormone releasing peptides, and the serious cautions around GLP microdosing gone wrong. She also shares her vision for what medicine could look like if doctors were equally fluent in peptides and pharmaceuticals. This is the conversation I've been wanting to bring to you for a long time. Dr. Sabrina Solt is one of the most precise and brilliant minds I know, and she does not hold back. WE GO DEEP ON: The cortisol-prolactin connection most doctors never test Why high cholesterol isn't always the villain (and what MPO reveals) The upstream-downstream mistake making "healthy" habits backfire Why NAD and glutathione drips can be dangerous for some people A no-BS peptide breakdown: BPC-157, TB-500, KPV, copper peptides, and more The truth about GLP microdosing and its risks What to fix before you ever try a peptide Catch the full episode on YOUTUBE HERE: https://bit.ly/MidlifeConversationsYouTube Learn More About Sabrina Solt Instagram ➜ http://www.instagram.com/drsolt Website ➜ http://www.stemcelltherapypro.com/ Peptide Membership Website ➜ https://dr-solts-peptide-corner.circle.so/forms/dfdcc2cd Thank you to our show sponsors: QUANTUM UPGRADE: Try Quantum Upgrade completely free for 15 days—no credit card required. Use code NATALIEJILL at checkout on https://quantumupgrade.io/start TIMELINE: Timeline is offering 20% off your order of Mitopure! Go to https://timeline.com/NATALIEJILL Free Gifts for being a listener of Midlife Conversations! Mastering the Midlife Midsection Guide: https://theflatbellyguide.com/ Age Optimizing and Supplement Guide: https://ageoptimizer.com Connect with me on social media! Instagram: www.Instagram.com/Nataliejllfit Facebook: www.Facebook.com/Nataliejillfit For advertising inquiries: https://www.category3.ca/ Disclaimer: Information provided in the Midlife Conversations podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before making any changes to your current regimen. Information provided in this podcast and the use of any products or services related to this podcast does not create a client-patient relationship between you and the host of Midlife Conversations or you and any doctor or provider interviewed and featured on this show. Information and statements may have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease. Advertising Disclosure: Some episodes of Midlife Conversations may be sponsored by products or services discussed during the show. The host may receive compensation for such advertisements or if you purchase products through affiliate links. Opinions expressed about products or services are those of the host and/or guests and do not necessarily reflect the views of any sponsor. Sponsorship does not imply endorsement of any product or service by healthcare professionals featured on this podcast.
Most of us assume that if we look healthy on the outside, our heart is fine on the inside, but today, preventive cardiology dietitian Michelle Routhenstein explains why that's exactly the assumption that gets women into trouble, especially through perimenopause and beyond. We get into the two numbers your doctor probably isn't checking, ApoB and Lp(a), the first five diet changes Michelle makes with clients to bring down high cholesterol numbers, why stretching may be doing as much for your arteries as it does for your joints, and why blood pressure, not HRV, deserves far more of your attention as you move through this life stage. WHAT YOU'LL LEARN ● Why heart disease can silently progress in women who look and feel healthy ● What ApoB and Lp(a) actually measure, and why they matter more than LDL and HDL alone ● The first five diet changes to lower high ApoB or non HDL cholesterol ● Why saturated fat, fiber, and gut health all influence your cholesterol numbers ● Why blood pressure, not HRV, deserves more of your attention in perimenopause ● How menopause hormone therapy really affects your cardiovascular risk ● The minerals your heart needs to keep beating and pumping properly TIMESTAMPS 00:00 Heart Disease Risk in Women: ApoB, Lp(a), and the Tests Your Doctor Isn't Running 10:18 The Hidden Inflammation Driving Your Heart Disease Risk (And How to Test for It) 19:29 The Truth About Saturated Fat and Cholesterol After 40 22:19 The First Five Diet Changes to Lower High ApoB or Non HDL Cholesterol 29:24 Bloating, Gut Health and Thyroid: The Hidden Heart Disease Risks in Perimenopause 39:41 Why Stretching Might Be Protecting Your Arteries, Not Just Your Joints 51:48 Does Menopause Hormone Therapy Actually Protect Your Heart? VALUABLE RESOURCES • Take the BioSyncing Quiz to help you understand what's actually happening in your body — and how to fix it.
What if fatigue, brain fog, slow recovery, and burnout aren't simply a lack of motivation—but a reflection of what's happening deep within your cells? In this Wellness Illuminated episode of Light Body Radio, Dr. Lara May explores the fascinating world of mitochondrial health, cellular energy production, and the role peptides can play in supporting resilience, healing, and healthy aging. You'll learn how the body creates ATP—the cellular energy currency that powers every process in the body—and why mitochondrial function is essential for everything from brain health and detoxification to recovery and repair. Dr. Lara also breaks down the relationship between NAD+, methylene blue, mitochondrial signaling, and why more isn't always better when it comes to supporting energy pathways. This episode offers a practical, science-informed look at how cellular energy impacts overall health and what it means to support your body intelligently rather than simply chasing more energy. © Light Body Radio-Podcast, 2026. All rights reserved. This podcast features background music by ScottHolmes Music. We have obtained the necessary licenses for the use of this music. Our license was renewed on May 7, 2024, and we have been using ScottHolmes Music since 2017. Unauthorized use or distribution of this podcast, including but not limited to the background music, is strictly prohibited and may result in legal action. For more information or to request permissions, please contact scott@scottholmesmusic.com.
MOTS-c is encoded by mitochondrial DNA, which makes it quite unique compared to most peptides, which are usually encoded by nuclear DNA. This peptide helps our bodies adapt to stress, regulate energy production, and maintain metabolic balance—especially when it comes to burning fat and improving overall endurance. Read the Full Episode Transcript: https://pepties.com/mitochondrial-support-from-mots-c/ Related Links/Products Mentioned: Peptide Podcast Partners Page https://pepties.com/partners/ Buy Peptides online at BioLongevity Labs: Use our link and enter COUPON CODE: PEPTIDEPODCAST at checkout to receive 15% off your total order: https://go.biolongevitylabs.com/SH5C Momentous Supplements (we use Creatine, Vital Aminos, Whey Protein) https://crrnt.app/MOME/OqGQOxGA LMNT – More Salt, Not Less. https://elementallabs.refr.cc/default/u/johnjavit Thorne Supplements (we use Omega-3 with CoQ10, Red Yeast Rice, Zinc) https://get.aspr.app/SH1KvW Organifi Creatine and Shilajit Gummies http://rwrd.io/rlbkajm?c MitoZen (methylene blue for Cognitive Function, Anti-Aging, Mental Clarity) https://www.mitozen.com/ref/cnlwiztypt/ For skin and hair health (Copper Tripeptide-1) Visit Luminose by Entera for an exclusive offer for Peptide Podcast listeners! ** Promo code PEPTIDEPODCAST at checkout for 10% off an order or 10% off the first month of a subscribe-and-save. ** https://www.enteraskincare.com/?rfsn=8906839.f93c72 NAD+ Push Patch: https://www.pushpatch.com/
I'm joined by Dr. Lauren Colenso-Semple to unpack the rapidly growing world of wellness peptides — from BPC-157 and CJC-1295 to Ipamorelin, Tesamorelin, NAD, and the so-called “fat-burning” and “healing” peptides taking over social media. We discuss what peptides actually are, why they've become so popular, and how legitimate medical therapies have blurred into a largely unregulated wellness industry.We also break down the claims being made about popular peptides marketed for fat loss, recovery, anti-aging, and performance enhancement, while taking a closer look at what evidence truly exists (and what doesn't). Dr. Lauren shares important insight into the safety concerns, marketing tactics, and cultural obsession with optimization that are fueling this trend online.If you've been curious about peptides or wondering whether the internet hype matches the science, this episode will help you think more critically before jumping on the trend.Check out Dr. Lauren Colenso-Semple's work here: https://www.drlaurencs.com/
Northam is a small town approximately 100KM East of Perth. During WW2 it supported the US Navy's 7th Fleet operating out of Fremantle. The nearby locality of Springhill housed the bunkers of the '7 Naval Ammunition Depot' (7 NAD) storing ordnance the US, British and Dutch submarines needed to take the war to the Japanese. Torpedoes, shells, small arms and explosives were housed there and shipped by rail to the port at Fremantle. 7 NAD was one of three US Naval Ammunition Depots throughout Australia, the others being at Mount Coot-tha, Brisbane and Newington, Sydney.
Try TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/Try Suppgrade Labs: https://shopsuppgradelabs.com/If you're eating clean, taking the right supplements, and still feel exhausted and mentally foggy - the problem isn't your protocol. Your body has a built-in cellular cleanup system that determines whether any of those inputs actually work, and right now it's almost certainly switched off. In this video, I break down what that system is, how chronic stress and all-day eating suppress it without you ever feeling it, and the specific compounds that flip the longevity switch back on through independent biological pathways that nothing else touches.Thank you to our sponsors!ECHO Water | Go to http://echowater.com/daveand use code DAVE10 for 10% off your ECHO Flask.EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:0:00 – The Longevity Switch0:47 – Why Mitochondria Matter2:28 – What Mitophagy Is2:46 – How Mitophagy Works4:18 – What Shuts It Off8:54 – The Damage Compounds9:22 – How to Turn It Back On10:31 – Signal 1: Fasting11:48 – Signal 2: Exercise (REHIT)12:30 – Signal 3: Cold Exposure13:22 – Signal 4: NAD+14:29 – Signal 5: Urolithin A and SpermidineConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
You don't die of old age. You die of the diseases aging causes — and Dr. Sandra Kaufmann says we can fight back.In this episode of Transparent with Tina, longevity physician Dr. Sandra Kaufmann breaks down the science of aging in a way that actually makes sense. From the 7 Tenets of Aging to cutting-edge tools like exosomes, NAD+, NMN, and senolytics — this conversation will change how you think about your body, your health, and your future.We go deep on:
What if the secret to overcoming chronic fatigue, brain fog, and cellular aging lies within your mitochondria? In this episode of The Better Life, host Dr. Mary Ann Pinkston sits down with international speaker, researcher, and cellular medicine expert Dr. Gordon Crozier from the Crozier Clinic. Together, they dive deep beneath the surface of traditional medicine to explore how integrative, evidence-based approaches can truly revitalize your health. If you’ve been slamming methylated B vitamins for MTHFR mutations but still feel completely exhausted, this conversation is the missing piece of your puzzle. What You’ll Learn in This Episode: The Truth About NAD+: Why this vital cellular coenzyme is essential for DNA repair, intense detoxification, and mitochondrial energy. NAD+ vs. Precursors: The difference between raw IV NAD+ (and why it causes nausea) versus cutting-edge precursors like NMN and True Niagen. The Magic of Methylene Blue: How this powerful antiviral compound works in concert with NAD+ to supercharge the electron transport chain—and why you must take structured breaks from it. Deep-Dive Methylation: Why methylation goes far beyond MTHFR, impacting hormone breakdown, breast and prostate cancer prevention, and neurodegenerative risks. Natural NAD+ Boosters: How everyday habits like proper weight management, targeted protein intake, and consistent exercise naturally elevate your levels. The Danger of "Supplement Overload": Why less is often more, and the hidden risks of buying non-third-party tested supplements off the shelf. Important Safety Note: Dr. Crozier explains why compounding quality matters and highlights critical contraindications for Methylene Blue, including SSRIs (Serotonin Syndrome risk) and G6PD deficiencies. Connect with the Experts: Find Dr. Gordon Crozier: Learn more about his practice, research, and social media at CrozierClinic.com. Find Dr. Mary Ann Pinkston: Access past episodes, resources, and links discussed in today's show at drpbetterlife.com. See omnystudio.com/listener for privacy information.
To read the The Rape Gang Inquiry Report To Support the work of Apologia -Our newest sponsor is Dominion Wealth Strategists! -Get the NAD treatment Jeff is on, go to Ion Layer and put “IONAPOLOGIA” into the coupon code and get $100 off your first three months! -Check out Amtac Blades and use code APOLOGIA in the check out for 5% off! -You can get in touch with Heritage Defense and use coupon code “APOLOGIA” to get your first month free! -For some Presip Blend Coffee Check out our Store. -Check out the Ezra Institute
Ketamine Therapy, MDMA, Psilocybin, and the Science of Psychedelic Assisted Healing Most people struggling with depression, anxiety, and trauma have never felt safe in their nervous system, and the treatments they have been prescribed are making that worse. This episode breaks down the neuroscience of psychedelic therapy, why ketamine is the safest and most accessible starting point, how MDMA triggers a BDNF dependent pathway that repairs trauma all the way down to the epigenetic code, and why your antidepressant may be blocking the very brain states required for real healing. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Order Dr. Rabin's Book ‘A Simple Guide to Being Alive': https://apolloneuro.com/pages/a-simple-guide-to-being-alive Host Dave Asprey sits down with Dr. Dave Rabin, MD, PhD, a senior research scientist at the Florida Institute for Human and Machine Cognition, Executive Director of The Board of Medicine, and co-founder and Chief Medical Officer of Apollo Neuroscience. Dr. Rabin received his MD and PhD in neuroscience from Albany Medical College and specialized in psychiatry at the University of Pittsburgh Medical Center. He has spent 20 years studying chronic stress and non-invasive therapies for treatment-resistant illness, and his primary research on MDMA assisted therapy for severe PTSD has demonstrated that trauma can be reversed at the epigenetic level, offering a genuine path to a cure. His upcoming book A Simple Guide to Being Alive publishes June 1, 2026 and is a science-backed manual for anyone who has ever felt overwhelmed by the modern world. Dave and Dr. Rabin break down why nearly 50% of people prescribed psychiatric medication never achieve remission, why SSRIs and SNRIs physically block the brain states required for emotional healing, and why the FDA rejected MDMA therapy after three trials showed an 88% response rate. They dig into the exact BDNF pathway that makes MDMA and ketamine so transformative, how psychedelics amplify safety learning in the amygdala at the molecular level, and why trauma passes down up to 14 generations through epigenetic code that can now be measured and repaired. They also cover why your breathing rate at the doctor's office is already a stress signal nobody is reading, how your smartphone puts your nervous system into a chronic fear state before you even get out of bed, and why ketamine is the right starting point for anyone curious about psychedelic therapy right now. You'll Learn: Why nearly 50% of psychiatric patients never get better and what treatment-resistant actually means How ketamine therapy works, why it is legal in every state, and why it is the safest place to start The exact BDNF pathway through which MDMA repairs fear extinction in the amygdala How MDMA assisted therapy produces measurable epigenetic repair of the cortisol receptor gene damaged by trauma Why SSRIs and SNRIs block the insula mediated brain states required for real emotional healing Why combining serotonergic psychedelics with SSRIs puts you at risk of life-threatening serotonin syndrome Why trauma passes down up to 14 generations and what you can do to stop the cycle now Why smartphones put your nervous system into a toxic overstimulation state before the day even starts How the FDA rejected MDMA therapy after 88% of patients responded and who paid to make that happen Thank you to our sponsors! - Qualia | If you want to take the guesswork out of maintaining high NAD+ levels as you age, go to www.qualialife.com/daveNAD to get clinically proven Qualia NAD+ backed by a 100 day money back guarantee and code DAVENAD at checkout gets you an extra 15% off. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE - OneSkin | For a limited time, try OneSkin with 15% off at oneskin.co/DAVE. - LMNT | Right now you can get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at drinkLMNT.com/dave Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dave Rabin, Dr. Dave Rabin, Apollo Neuroscience, A Simple Guide to Being Alive, ketamine therapy, MDMA assisted therapy, psilocybin therapy, psychedelic assisted therapy, treatment-resistant depression, treatment-resistant mental illness, BDNF pathway, fear extinction amygdala, vagus nerve activation, trauma epigenetics, cortisol receptor gene, epigenetic repair, serotonin syndrome, SSRI alternatives, MDMA BDNF, ketamine BDNF, nervous system safety, autonomic nervous system, parasympathetic nervous system, generational trauma, trauma self-trust, MAPS MDMA trial, FDA MDMA rejection, pharmaceutical interference MDMA, breathing rate stress, smartphone nervous system, Apollo Neuro wearable, Board of Medicine, theboardofmedicine.org, insula cortex, psychedelic safety protocol, ketamine legal therapy, MDMA 88 percent, bottom-up learning psychedelics, trauma fractured self-trust, 14 generations trauma, stress breathing range Resources: • Order Dr. Rabin's Book ‘A Simple Guide to Being Alive': https://apolloneuro.com/pages/a-simple-guide-to-being-alive • Purchase Dr. Fotuhi's New Book The Invincible Brain: https://a.co/d/0iHCgPpL • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 01:34 – Dave Rabin Introduction 05:01 – Psychedelics and Psychiatry 08:35 – Psychedelic Safety and Dosing 14:53 – Serotonin Syndrome Warning 21:17 – Vagus Nerve and Safety 27:36 – Smartphones and Chronic Stress 34:18 – Defining Trauma 38:00 – Trauma and Epigenetics 40:23 – MDMA Cortisol Gene Repair 44:44 – Therapy vs. Medicine Alone 49:15 – FDA MDMA Rejection 55:35 – Ketamine Personal Experience 59:15 – Closing and Book Recommendation See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
NAD is everywhere right now: supplements, injections, podcast topics, longevity clinics. And I'll be honest, when something gets this trendy, I get skeptical. But NAD is different. This is actually something I've been watching closely for nearly 25 years, and the science has finally caught up.Here's what most people don't realize: the exhaustion, the brain fog, the slower recovery you've been chalking up to "just getting older"? That's often your NAD levels in freefall, and it's happening earlier than you think.On this episode, I'm breaking down what NAD actually does inside your cells, why most supplements on the market are quietly failing you, and what I looked for when I finally designed my own formula — Gundry MD Elevate NAD+. I spent years waiting to make one until I could develop an NAD supplement that delivered you real results. On this episode, you'll learn: What the "second baseman" is, and why it is the most important player in your cellular health (3:09)All about the French Paradox and its connection to NAD research (4:32)What fasting and strength training have in common that no one talks about (6:15)The dirty secret about most NMN supplements on the market (7:35)3 reasons your NAD gets depleted (and what a well-designed formula like Gundry MD Elevate NAD+ actually does about it) (15:25)The checklist I use to evaluate any NAD supplement (17:41)What age should you actually start thinking about NAD support (12:21)What real NAD support looks like in practice (hear my personal story) (10:57)A special thank you for being part of our podcast family, use code PODCAST25 for 25% off your purchase of my brand-new NAD supplement. Code valid until 4/9/27 on all regular priced items. My Account and subscription price excluded. Can not be combined with other offers. Does not apply to bundles, devices and digital products.For full show notes and transcript: https://drgundry.com/Gundry-MD-NAD-SupplementThank you to our sponsors! Check them out: Take your water to the next level with the AquaTru water purifier, go to aquatruwater.com and enter code “GUNDRY20” at checkout for 20% off.Get $20 off your first box plus a free year of protein, like sirloin or ribeye at ButcherBox.com/GUNDRY.Visit Juvent.com/GUNDRY and use code GUNDRY at checkout to get an extra $300 off your Juvent Micro-Impact Platform.Get a quote today at Progressive.com.Shop my new air filter, Homekind Total Air! Use code CLEANAIR for 10% off. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Today we're exploring the intersection of genetics and environmental health. Our guest specializes in how estrogen mimicking chemicals in our everyday environment can disrupt the body and impact long-term wellness. We'll be diving into why we're seeing rising health issues like obesity and fertility, depression, cancer, even the feminization of males, as well as what you can do about it. This is the Story of Estrogenics with Dr. Anthony Jay. EPISODE VIDEO HIGHLIGHTS ▪ Watch the Entire Episode CONNECT WITH DR. ANTHONY JAY▪ Website - AJ Consulting Company ▪ Instagram ▪ YouTube ▪ Purchase the Book - Estrogeneration: How Estrogenics Are Making You Fat, Sick, and InfertileLEARN MORE ABOUT US▪ Subscribe on YouTube ▪ ‘Your Health. Your Story.' Podcast: Follow on Spotify, Apple Podcasts, and Instagram ▪ Follow our podcast host, Caspar Szulc on Instagram ▪ Sign up for Caspar's newsletter LEARN MORE ABOUT NADOVIM Doctor-formulated, clinically-tested NAD+ supplement. Visit our website and save 10% on your first order by using code NADOVIM10. Disclaimer: The content presented on the podcast is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.
GLP-1 agonists, like semaglutide (brand names Ozempic and Wegovy), are peptides that mimic this natural hormone. They're typically used for managing type 2 diabetes and, more recently, for weight loss. These peptides work by enhancing insulin secretion when glucose levels are elevated, slowing down gastric emptying, and reducing appetite. They also help lower blood pressure and stabilize blood sugar and cholesterol levels. Most recently they've been approved for improving cardiovascular health. Read the Full Episode Transcript: https://pepties.com/glp-1-microdosing/ Related Links/Products Mentioned: Peptide Podcast Partners Page https://pepties.com/partners/ Buy Peptides online at BioLongevity Labs: Use our link and enter COUPON CODE: PEPTIDEPODCAST at checkout to receive 15% off your total order: https://go.biolongevitylabs.com/SH5C Momentous Supplements (we use Creatine, Vital Aminos, Whey Protein) https://crrnt.app/MOME/OqGQOxGA LMNT – More Salt, Not Less. https://elementallabs.refr.cc/default/u/johnjavit Thorne Supplements (we use Omega-3 with CoQ10, Red Yeast Rice, Zinc) https://get.aspr.app/SH1KvW Organifi Creatine and Shilajit Gummies http://rwrd.io/rlbkajm?c MitoZen (methylene blue for Cognitive Function, Anti-Aging, Mental Clarity) https://www.mitozen.com/ref/cnlwiztypt/ For skin and hair health (Copper Tripeptide-1) Visit Luminose by Entera for an exclusive offer for Peptide Podcast listeners! ** Promo code PEPTIDEPODCAST at checkout for 10% off an order or 10% off the first month of a subscribe-and-save. ** https://www.enteraskincare.com/?rfsn=8906839.f93c72 NAD+ Push Patch: https://www.pushpatch.com/
In a world dominated by indie horror films like Obsession and Backrooms, where does Star Wars stand? A couple of weeks ago, an article was published where Damon Lindelof talked about his canceled Star Wars movie, saying it would have been about the fight between nostalgia and reinvention. This film was the colloquially named by fandom, NEW JEDI ORDER, staring Rey portrayed once again by Daisey Ridley and directed by Sharmeen Obaid-Chinoy.What are the implications of the themes Damon Lindelof talked about his script for this film and Star Wars as a whole? Is there a chance that his ideas will be incorporated into Simon Kinberg's alleged X, XI, XII Trilogy?Today we discuss the current state of Star Wars and speculate what Rey's journey could look like in a potential new-Sequel Trilogy. Is the Protestant Reformation of Star Wars upon us?• • •TRIAD Of The FORCE is a STAR WARS+ podcast hosted by Gus, Nani, Nad, & Chase—Puerto Rican and queer creators sharing deep dives, and heartfelt conversations from a galaxy far, far away. Featured on the STAR WARS CELEBRATION Podcast Stage (2022 & 2023), we explore STAR WARS, fantasy, comic books, and other POP-culture media honestly. We engage in inclusive commentary across film, TV, books, comics, and beyond with humor, critical analysis, and cultural perspective (without the toxicity).Follow TRIAD Of The FORCE at:BlueSky: https://bsky.app/profile/triadoftheforce.bsky.socialInstagram: https://www.instagram.com/triadoftheforce/YouTube: https://www.youtube.com/c/TriadoftheForce/If you like us, get some merch and help the channel:TeePublic: https://www.teepublic.com/user/triad-of-the-force• • •Acknowledgement: The Intro and Outro music is the Triad of the Force Theme, composed and performed by Grushkov with full permission for use by Grushkov (https://linktr.ee/Grushkov).• • •This channel is not affiliated in any way with Lucasfilm Ltd. LLC, The Walt Disney Company, or any of their affiliates or subsidiaries.
When is a “100%” claim not as clear as it seems? In this episode, we unpack a recent NAD decision examining how consumers interpret absolute claims and why advertisers should be cautious when using “100%” messaging in marketing. The case highlights NAD's continued focus on consumer takeaway, substantiation, and context, emphasizing that even simple, seemingly straightforward claims can convey broader messages than advertisers intend. As regulators, self-regulatory bodies, and plaintiffs increasingly scrutinize absolute and unqualified representations, the decision offers valuable guidance for companies looking to balance compelling marketing with defensible advertising claims. Hosted by Simone Roach. Based on a blog post by Gonzalo E. Mon.
When summer skin starts looking dull, congested, tired, or slower to recover, it is easy to blame the obvious things: heat, sweat, sunscreen, long days outside, or the wrong moisturizer. So the conversation usually stays on the surface. Use SPF. Cleanse better. Switch to lighter products. Add antioxidants. But before we treat summer skin like another product problem, there is a deeper question worth asking: what is the sun doing to the cell before you ever see the damage in the mirror?In this episode of Biohacking Beauty, I want to take the sun conversation past burns, wrinkles, and dark spots. I'm walking through what UV exposure does to the systems your skin depends on to keep up with summer: cellular energy, NAD, mitochondrial function, and DNA repair. Because the skin does not only need protection from the sun. It also needs enough repair capacity to deal with the damage that gets through.Young Goose's Skin Under the Sun campaign is active from June 15 through June 28 at younggoose.comWhat's Discussed:(01:50) The light-activated repair tool humans lost.(06:10) Why NAD matters for skin energy and repair.(10:15) How UV exposure increases oxidative stress and disrupts NAD supply.(16:44) What UV-induced DNA lesions are and why CPDs matter.(22:21) Why L.A.D.R. serum was built around light-activated repair-inspired science.(31:52) Why the sun is one of the biggest controllable inputs into biological skin aging.(35:43) The five protocol-level moves for supporting skin through summer.Listen to this episode of Biohacking Beauty to understand what UV is doing under the surface and how to build a smarter summer protocol around protection, energy, and repair.Resources Mentioned:Age-Associated Changes in Oxidative Stress and NAD+ Study: journals.plos.org/plosone/article/FASEB study on how methylene blue delays cellular senescence cells: faseb.onlinelibrary.wiley.com/doi/Find more from Young Goose:Use code PODCAST10 to get 10% OFF your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincare
Leveling Up: Creating Everything From Nothing with Natalie Jill
Don't miss the free live hydrogen workshop with Kashif. Save your seat at https://midlifeconversations.com/hydrogen What if every biohack you've tried has been missing the one piece that actually makes it work? Red light, peptides, cold plunges, NAD, wellness IVs. You've tried some of them. Some worked. Some didn't. And here's the maddening part: your friend is thriving on the same protocol that made you feel worse. That's not random, and you're not broken. There's a reason, and it's rooted in your unique biology in ways most practitioners never explain. In this episode, I sit down with Kashif Khan, founder of The DNA Company and someone I genuinely call my health guru. Kashif healed himself from a cascade of chronic conditions including eczema so severe his eye was sealed shut, psoriasis, gut issues, migraines, and depression, all by going deep into functional genomics rather than accepting diagnoses and prescriptions. He now runs what may be the largest functional medicine clinic in the country by volume, working with the most complex cases imaginable. We cover what red light actually does inside your mitochondria and how you can completely overdo it, the real reason peptides cause side effects when used without proper sequencing, why 89% of your cholesterol score has nothing to do with food, and the one molecule Kashif keeps coming back to no matter who the patient is. We also go deep on why hydrogen tablets and bottles are not doing what you think they're doing and what the research actually shows it takes to move the needle. This is one of those conversations that makes you rethink everything. Listen all the way through. WE GO DEEP ON: Why the same biohack transforms your friend but wrecks you What red light really does inside your cells and how to overdo it Why peptide order matters more than peptide choice Why 89% of your cholesterol score has nothing to do with food Why hydrogen has peer-reviewed studies on every chronic disease Hydrogen tablets vs. breathing: a tablet equals about 20 seconds How to rebuild the 70% of mitochondria you've lost since your 50s Cold plunges, saunas, PEMF, and wellness IVs: what's worth it and what isn't Catch the full episode on YOUTUBE HERE: https://bit.ly/MidlifeConversationsYouTube Learn More About Kashif Khan Instagram ➜ https://www.instagram.com/kashkhanofficial Website ➜ https://midlifeconversations.com/hydrogen Free Gifts for being a listener of Midlife Conversations! Mastering the Midlife Midsection Guide: https://theflatbellyguide.com/ Age Optimizing and Supplement Guide: https://ageoptimizer.com Connect with me on social media! Instagram: www.Instagram.com/Nataliejllfit Facebook: www.Facebook.com/Nataliejillfit For advertising inquiries: https://www.category3.ca/ Disclaimer: Information provided in the Midlife Conversations podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before making any changes to your current regimen. Information provided in this podcast and the use of any products or services related to this podcast does not create a client-patient relationship between you and the host of Midlife Conversations or you and any doctor or provider interviewed and featured on this show. Information and statements may have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease. Advertising Disclosure: Some episodes of Midlife Conversations may be sponsored by products or services discussed during the show. The host may receive compensation for such advertisements or if you purchase products through affiliate links. Opinions expressed about products or services are those of the host and/or guests and do not necessarily reflect the views of any sponsor. Sponsorship does not imply endorsement of any product or service by healthcare professionals featured on this podcast.
What Causes Cancer? The Truth Most Doctors Don't Talk AboutIn this episode of Intellectual Medicine, Dr. Stephen Petteruti explores the relationship between cancer, metabolism, sugar, insulin, body fat, and prostate cancer progression. He discusses the Warburg theory, which suggests that cancer may begin with dysfunctional mitochondrial metabolism, and compares it with the later focus on genetic causes of cancer. While he argues that the idea of “starving cancer” by eliminating sugar is too simplistic, he also emphasizes that metabolic health plays a real role in cancer risk and progression.The episode focuses heavily on prostate cancer, which Dr. Petteruti describes as unique compared with other cancers. He argues that conventional approaches often overlook the environment in which cancer develops, including excess body fat, high insulin, elevated blood sugar, inflammation, and poor metabolic health. He also discusses tests such as fasting insulin, hemoglobin A1c, and continuous glucose monitoring, as well as the importance of nutritional and behavioral change. The episode closes with a warning against extreme diets, oversimplified supplement advice, and one-size-fits-all cancer theories.Timestamps:(00:00) What Causes Cancer?(01:02 )The Warburg Theory(02:14) Genetics vs. Metabolism(04:22) Why “Starving Cancer” Is Too Simplistic(05:42) Body Fat, Insulin, and Prostate Cancer(08:30) Tests That May Help Assess Metabolic Health(10:47) Food, Weight Loss, and Cancer Risk(13:42) The Anti-Cancer Lifestyle(15:04) Toxins, Viruses, and Parasites(16:15) NAD, Mitochondria, and Supplement Caution(17:33) Growth Hormone, IGF-1, and Cancer Risk(19:12) Why Extreme Dieting Is Not the AnswerEnjoy the podcast? Subscribe and leave a 5-star review on your favorite platforms.Dr. Stephen Petteruti is a board-certified physician specializing in longevity-focused, integrative medicine. He works with men navigating prostate cancer, testosterone, and hormone health, aging, and performance using proactive, evidence-informed strategies grounded in real clinical practice. His approach prioritizes preserving function, strength, and quality of life while helping patients make clear, informed decisions beyond reactive, fear-driven care.Book: Fight Cancer Like a Man: https://tinyurl.com/FightLikeAManBookDr. Steve's email newsletter: https://drstephenpetteruti.substack.com/subscribePodcast show notes : https://www.intellectualmedicine.com/podcast-notesMember exclusive content: https://tinyurl.com/DrPetterutiMemberLearn more: https://www.drstephenpetteruti.com/ Learn more: https://www.intellectualmedicine.com/ Connect with Dr. Petteruti on:Instagram: https://www.instagram.com/dr.stephenpetteruti/ Facebook: https://www.facebook.com/dr.stephenpetteruti Disclaimer:The content presented in this video reflects the opinions and clinical experience of Dr. Stephen Petteruti and is intended for informational and educational purposes only. It is not medical advice and should not be used as a substitute for professional diagnosis, treatment, or guidance from your personal healthcare provider. Always consult your physician or qualified healthcare professional before making any changes to your health regimen or treatment plan.
Chad Hyams and Bob Stewart host Mike Linares, an expert in health and longevity. Delve into aging, fatigue, brain fog, and the science behind reversing the aging process. Explore lifestyle strategies and supplements like NMN and NAD. Mike discusses the benefits and limitations of popular health trends such as cold plunges, saunas, and red light therapy, providing practical advice on living healthier. Discover the potential of fasting, glutathione, and stem cells. Mike Linares, a successful YouTube educator, shares insights from his work with Longevity Farms and Rejuvenate Peptides. Connect with Mike https://simplenursing.com/author/mike-linares/ https://www.instagram.com/mike.linares/?hl=en ---------- Connect with the hosts: • Ben Kinney: https://www.BenKinney.com/ • Bob Stewart: https://www.linkedin.com/in/activebob • Chad Hyams: https://ChadHyams.com/ • Book one of our co-hosts for your next event: https://WinMakeGive.com/speakers/ More ways to connect: • Join our Facebook group at www.facebook.com/groups/winmakegive • Sign up for our weekly newsletter: https://WinMakeGive.com/sign-up • Explore the Win Make Give Podcast Network: https://WinMakeGive.com/ Part of the Win Make Give Podcast Network
Today, we're talking about sermorelin peptide therapy, an emerging peptide therapy option that's gaining attention for its potential benefits in anti-aging, muscle health, and overall vitality. Whether you've heard about it before or are learning about it for the first time, this episode will break down exactly what sermorelin is, how it works, and why some people are turning to it for a boost in their health. Read the Full Episode Transcript: https://pepties.com/sermorelin/ Related Links/Products Mentioned: Peptide Podcast Partners Page https://pepties.com/partners/ Buy Peptides online at BioLongevity Labs: Use our link and enter COUPON CODE: PEPTIDEPODCAST at checkout to receive 15% off your total order: https://go.biolongevitylabs.com/SH5C Momentous Supplements (we use Creatine, Vital Aminos, Whey Protein) https://crrnt.app/MOME/OqGQOxGA LMNT – More Salt, Not Less. https://elementallabs.refr.cc/default/u/johnjavit Thorne Supplements (we use Omega-3 with CoQ10, Red Yeast Rice, Zinc) https://get.aspr.app/SH1KvW Organifi Creatine and Shilajit Gummies http://rwrd.io/rlbkajm?c MitoZen (methylene blue for Cognitive Function, Anti-Aging, Mental Clarity) https://www.mitozen.com/ref/cnlwiztypt/ For skin and hair health (Copper Tripeptide-1) Visit Luminose by Entera for an exclusive offer for Peptide Podcast listeners! ** Promo code PEPTIDEPODCAST at checkout for 10% off an order or 10% off the first month of a subscribe-and-save. ** https://www.enteraskincare.com/?rfsn=8906839.f93c72 NAD+ Push Patch: https://www.pushpatch.com/
Shahayra Majumder and Jonathan Chizever - Hydrate IV Bar Madison, WI On Focusing on What Really Matters: "They're passionate about their health, which is your only wealth at the end of the day." What good is money if you're spending your time hurting and not able to enjoy this great gift of life that we have all been given? Health is arguably the most important thing to focus on, to make sure you can do the things you want to do. Whether that is growing a business or enjoying time with friends. Shahayra and Jonathan set out to help boost the health of the midwest by starting a Hydrate IV Bar franchise in Madison, Wisconsin. Through our candid conversation you will learn what is a IV bar, why do people get IV drips and how they started this business in the IV drip world. Learn how they identified a gap in the Midwest's wellness market, navigated the highly regulated and rapidly evolving IV bar industry, and brought a community-focused approach to health and hydration. Are you curious about how IV therapy went from hospital wards to vibrant wellness lounges? Or what it takes to build a franchise rooted in both science and local values? This conversation will open your eyes to the business challenges, customer stories, and passion that drive this growing trend. Shahayra and Jonathan share some great insights into franchise selection, the science behind vitamin infusions, building a winning team, and the power of connection within a unique new “third space” for health-minded people. Listen as they explain the power of IV drips and how they can help you in your health and life journey. Enjoy! Visit Shahayra and Jonathan at: https://hydrateivbar.com/locations/madison/ Sponsors: Calls On Call Extraordinary Answering Service, phone answering for small businesses: https://callsoncall.com Some videos have been recorded with Riverside: https://www.riverside.fm/?utm_campaign=campaign_5&utm_medium=affiliate&utm_source=rewardful&via=james-kademan Podcast Overview: 00:00 Bringing IV therapy to Madison 05:39 Navigating Franchise Regulations 07:47 IV therapy goes mainstream in Tokyo 12:50 Curated med spa offerings 14:44 Choosing Hydrate IV Bar for Madison 19:02 Starting with franchise questions 20:37 Building a Health-Focused Community 24:53 Benefits of Vitamin D Supplementation 27:55 Challenges with supplement patents 32:20 Functional medicine consultations at Hydrate 34:08 Patient advocacy and safe care 39:05 Frequency of sessions per week 41:33 Supplements and their credibility 47:04 Choosing the right location 48:42 Optimizing franchise location space 52:48 Hiring nurses for IV procedures 56:16 Spa services and mobile options Podcast Transcription: Jonathan Chizever [00:00:00]: This gentleman with Parkinson's started supplementing the NAD with us, and the results we're seeing are just, like, amazing. He's not perfect in running marathons, but he's walking around without his hunch in his cane. I check in with his wife the next day, like, hey, how's he doing? And she's like, I couldn't believe it. I woke up and I walk out and he was up before me, which is rare. And he's sitting in his chair in the living room, giant smile plastered across his face. And. And it's like, what's going on? And then I see him get out of the chair, stand up with no cane, no hunch, and he's like, I feel better than I felt in a long time because of something that we all. James Kademan [00:00:41]: You have found authentic business adventures business program that brings you the struggle stories and triumphant successes of business owners across the land. Downloadable audio episodes can be found in the podcast link found@drawincustomers.com we are locally unwritten by the bank of Sun Prairie, and today we're welcoming, preparing to learn from Sahara and Jonathan of the Hydrate IV bar. So, Sahara, Jonathan, how are you guys doing today? Jonathan Chizever [00:01:06]: Wonderful. Excited to be here. James Kademan [00:01:08]: Yeah. Shahayra Majumder [00:01:08]: Woot, woot. James Kademan [00:01:09]: Let's talk about Hydrate IV bar. I don't know what in the world an IV bar is, and I bet a lot of people don't either. So let's just start with what is an IV bar? Jonathan Chizever [00:01:18]: Happy to tell them you want to go or want me to go? Shahayra Majumder [00:01:20]: Um, yeah, I'll kick it off if you want to add in, if there's anything that I miss. But have you ever had an IV before? James Kademan [00:01:28]: I had. Yes. I had a saline IV thing when I had a. A gut thing, a stress gut thing Shahayra Majumder [00:01:35]: way back when, probably in the hospital. James Kademan [00:01:37]: Yeah. Yeah. Not a fan. Shahayra Majumder [00:01:39]: Yeah. James Kademan [00:01:41]: Not a fan of being in the hospital. Shahayra Majumder [00:01:42]: Yeah, right. Yeah, I. A lot of people are used to thinking about IVs being something that you get in the hospital or at urgent care in an emerg situation. But an IV bar actually takes those services outside of an emergency situation and lets you be a little more proactive about rapidly rehydrating your body. James Kademan [00:02:04]: All right. Shahayra Majumder [00:02:05]: For your different health and wellness goals. There's lots that we can do with supplementing things that you might be deficient in or if you're just feeling certain ailments that could be improved with additional vitamin supplements, meditation, or hydration. That's usually why people come to an IV bar. For me, it's been more of a proactive thing. I realized as I started doing IVs on a regular basis, I felt more energy. I was getting sick less. I didn't really let anything get me down as much. Like during cold and flu season. Shahayra Majumder [00:02:49]: Yeah. Anything that you would add to that, Jonathan Chizever [00:02:52]: I think that sums it up. Great. Yeah. James Kademan [00:02:54]: All right. How do you get in the IV bar business? Shahayra Majumder [00:02:58]: You take that one. Jonathan Chizever [00:03:01]: So we both, in our travels, neither of us are from Madison. I've been here 10 years. Sahara's been here seven. And we've both, in our travels and living other places, seen this as a more established concept in other places. And, you know, in the Midwest, whether it's fashion trends or wellness modalities, we're generally the last to get just about everything. And so here we are. And so, you know, IVs have saved us in numerous occasions from feeling bad, and really, until we got in the business, didn't yet understand how much it can make you feel good in a consistent and proactive sense. But we just saw this as a market that makes so much sense for it, because, you know, what people traditionally associate it with is hangovers, at least in the selective sense, which it is phenomenal for, I've heard, at least. Jonathan Chizever [00:03:54]: But. But beyond that, you know, like, the founder of our brand, she got into this. She was a Broncos cheerleader, and she noticed all the guys in the team are doing these IVs routinely, all the time. And that was part of her origin story of getting into this. And so athletes love it, and athletes have been ahead of the curve and, you know, taking advantage of this. So for athletics and drinking Madison, we have a lot of bubbles, and turns out. James Kademan [00:04:24]: Yeah, yeah. Jonathan Chizever [00:04:25]: So. And then beyond that, we also have a very vibrant wellness scene. You know, we have a population that likes to take care of themselves. And, I mean, in so many ways, it made sense, but it was something that we saw being severely underserved. So it wasn't like we wanted to start a business. And we're like, what business do we do? It was like we noticed that there was a gap in the availability of these types of services in a place that it makes so much sense to have them. And the rest kind of naturally came from there. James Kademan [00:04:55]: Right on. So did you hunt down a franchise, or did you get introduced to the franchise? And you're like, yes, that's what we want. Shahayra Majumder [00:05:03]: Little column A, little column B. I did interview, like, every franchise under the sun doing IV stuff. James Kademan [00:05:09]: All in the IV stuff. Shahayra Majumder [00:05:10]: Yes. James Kademan [00:05:11]: Okay, how many are we talking here? Shahayra Majumder [00:05:12]: Oh, my God. I think I Started talking to folks in September of 2024, and then we signed our franchise agreement February of 25. So, yeah, I mean, that gives you a little gauge. It took me months and months of. James Kademan [00:05:27]: So just talking like, I don't know how many franchise I've seen. Are we talking five? We talking 50? Jonathan Chizever [00:05:32]: Oh, no, I'd say a dozen and a half maybe. Shahayra Majumder [00:05:35]: Yeah, maybe closer to like the 20 or 30. Jonathan Chizever [00:05:37]: Wow. Shahayra Majumder [00:05:39]: Yeah, franchise franchises. And there are a few that dominate the market. There are a few that are bigger. But what's interesting is this industry, it's very highly regulated, but the regulations are different state to state. So if you know a little bit about franchising, you know that franchises have to be registered in every single state. And some states are harder to get registered in. And so I talked to a lot of the folks that I was able to get their franchisees on the phone and get honest opinions about the kind of support they're receiving, how the market has received them. I particularly talk to folks in the Midwest or familiar with the Midwest because, you know, the market in the Midwest is not going to be what it is in, you know, Nashville, Tennessee, for example, where you're getting a lot more tourism and. James Kademan [00:06:38]: Yeah, sober me up. Sober me up. ...
Andrew Huberman takes it. Peter Attia has been talking about it for years. Every serious longevity researcher has an opinion on it. And by age 40 to 60, your levels have already dropped by 50%. NAD+ is one of the most important molecules in your body. It powers energy production in every cell, repairs DNA damage every single day, and activates the cellular pathways that regulate aging, inflammation, and metabolic function. The biology is not hype. But the way most people are taking it right now almost guarantees it is doing nothing. And Dr. G is done watching people waste their money on the wrong molecule in the wrong form at the wrong dose. In this episode, you will learn: • Why you cannot raise your cellular NAD+ levels by swallowing NAD+ directly, what happens to the molecule in your digestive tract, and the precursors that actually work • The clinical research on NR vs NMN, which one has more published human trial data, which one the longevity research community is most excited about, and why sublingual delivery changes everything • Why the serving sizes on most NAD+ labels are set to make the price look reasonable rather than match the research, and what a therapeutic dose actually looks like Plus the specific brands Dr. G uses and trusts, and how to test your own intracellular NAD+ levels before and after to see if your stack is actually working. Timestamps: 0:00 - NAD+ Drops 50% Between Ages 40 and 60 — Here's Why That Matters 1:37 - What NAD+ Actually Does in Every Cell of Your Body 2:15 - The Fatigue, DNA Damage & Accelerated Aging Tied to NAD+ Decline 3:39 - The Real Question: Is What You're Buying Actually Doing Anything? 4:09 - Why You Cannot Raise NAD+ by Swallowing NAD+ Directly 4:59 - The Three Precursors That Actually Work: Niacin, NR & NMN Explained 6:49 - NR vs. NMN: What the Latest 2026 Research Actually Says 7:34 - Why Most NAD+ Products on the Market Are Dangerously Underdosed 9:06 - Who Should Actually Be Taking NAD+ Precursors (And Who Can Wait) 10:14 - Dr. G's Clinical Recommendation: Sublingual NMN, Proper Dosing & Resveratrol Stacking 11:28 - How to Test Your NAD+ Levels Before and After Supplementing 11:42 - The Brands Dr. G Recommends Learn more about your ad choices. Visit megaphone.fm/adchoices
Vita Bella Health Membership: https://vitabella.com/membership/Follow Phil Vella (CEO of Vita Bella Health) on IG: @phillyvzAccredited Investors: Catalina Island deal closes soon. Join waitlist: somerscapital.com/investRich Somers sits down with Phil Vella, CEO of Vita Bella Health, to talk about the future of health, hormones, peptides, GLP-1s, and the massive shift happening in human performance. Phil breaks down why testosterone can be the foundation for men's health, how peptides and NAD+ are being used for energy, recovery, and longevity, and why weight-loss drugs like semaglutide and tirzepatide are only the beginning of what he calls the “biology boom.”They also dive into the dangers of chasing quick fixes, the risks of gray-market peptides, and why true health still comes back to discipline, muscle, nutrition, and building the right foundation. From anti-aging and hormone optimization to masculinity, leadership, and becoming a stronger man, this episode explores what the next era of health could look like and what people need to know before jumping in.Connect with Rich on Instagram: @rich_somersInterested in joining The 7 Figure Creator Mastermind? Visit www.the7figurecreator.com to book a free intro call.Interested in joining our Boutique Hotel Mastermind? Visit www.somerscapital.com/mastermind to book a free call.
KRISTIN BAVER is a Star Wars legend. Kristin is a journalist who has been the editor-in-chief of StarWars.com since 2024. Not only that, but she hosted This Week! In Star Wars, and served as the inspiration for KB-68 in Adam Christopher's Shadow Of The Sith as well as Kitrin Braves in The Rise And Fall Of The Galactic Empire by Dr. Chris Kempshall. Additionally, she is an accomplished author who has written Skywalker: A Family at War, and The Art of Star Wars: The High Republic: Volume I, and Volume II. Most recently, she authored The Art of Star Wars: THE ACOLYTE, a book which like many of the rest of The Art Of... series, chronicles production art, character and vehicle designs, planets, storyboards, and other breathtaking work from the series. Today, we're so very privileged to talk to Kristin about her career and work on this wonderful book which showcases so much incredible art from this amazing show.The Acolyte was a show we enjoyed deeply and despite its untimely end, we continue to celebrate it with Kristin through the work of so many incredible artists!Thank you to ABRAMS for facilitating this interview!• • •TRIAD Of The FORCE is a STAR WARS+ podcast hosted by Gus, Nani, Nad, & Chase—Puerto Rican and queer creators sharing deep dives, and heartfelt conversations from a galaxy far, far away. Featured on the STAR WARS CELEBRATION Podcast Stage (2022 & 2023), we explore STAR WARS, fantasy, comic books, and other POP-culture media honestly. We engage in inclusive commentary across film, TV, books, comics, and beyond with humor, critical analysis, and cultural perspective (without the toxicity).Follow TRIAD Of The FORCE at:BlueSky: https://bsky.app/profile/triadoftheforce.bsky.socialInstagram: https://www.instagram.com/triadoftheforce/YouTube: https://www.youtube.com/c/TriadoftheForce/If you like us, get some merch and help the channel:TeePublic: https://www.teepublic.com/user/triad-of-the-force• • •Acknowledgement: The Intro and Outro music is the Triad of the Force Theme, composed and performed by Grushkov with full permission for use by Grushkov (https://linktr.ee/Grushkov).• • •This channel is not affiliated in any way with Lucasfilm Ltd. LLC, The Walt Disney Company, or any of their affiliates or subsidiaries.
Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember
Join Liz Cruz M.D. and Tina Nunziato, Certified Holistic Nutrition Consultant, as they discuss the very hot topic of NAD. Hear why it's stuch a hot topic, learn what it is and how to increase it naturally. Also, if you're interested in supplementing it, find out the best way to do so and cut through all the noise. Mid-podcast commercial was on the Delicate Detox. Please check out this link for more information: https://drlizcruz.com/collections/supplements/products/dr-liz-cruz-delicate-detoxWatch us on YouTube: https://youtu.be/0HKitj7G6jUDr. Cruz is a Board Certified Gastroenterologist who practices in Phoenix, AZ. Along with her wife Tina Nunziato, a Certified Holistic Nutritionist, they have helped tens of thousands of individuals get well from a more holistic standpoint. They focus on issues such as constipation, diarrhea, acid reflux, heartburn, gas, bloating, food sensitivities, IBS, Crohn's disease, and diverticulitis in addition to a person's general overall health. They do this by teaching about real food, water, digestive enzymes, probiotics, detox, greens, electrolytes, food sensitivity testing, and so much more. If you're struggling with finding the answers to your issues, tired of not feeling well, and sick of taking over the counter and prescription medicines, schedule a FREE 30 minute phone consult at www.drlizcruz.com.
Every fibroblast inside your dermis right now is asking 200 to 2,000 mitochondria to power its work in real time, and those mitochondria are descendants of a free-living bacterium swallowed by a larger cell 2 billion years ago. As you age, those mitochondria run slower and your cells build fewer of them to replace the ones that fail.In this solo episode, Young Goose co-founder Amitay Eshel breaks down the two sides of mitochondrial decline that drive skin aging and explains why the science-led skincare category has spent the last decades addressing only one of them.The first side of skin aging is where most skincare brands have built their products around. The other side is the one almost no skincare on the market is formulating for, and it is where the next chapter of skin longevity is being written.If you have outgrown the antioxidant-and-peptide era of skincare and want to understand what is actually happening underneath your skin as it ages, this episode is for you.What's Discussed:(01:35) The 2-billion-year-old contract inside every skin cell that is now fraying.(04:10) Why skin is one of the most mitochondria-dense organs in your body.(08:20) The 2012 paper that showed NAD drops by half between 35 and 70.(13:15) How a refugee fired in 1933 figured out the chemistry your cream still runs on.(16:30) The second half of the decline almost no skincare addresses.(19:45) The master regulator that decides whether your cells can hire.(24:00) The two columns of mitochondrial biology and why most brands only work in one.(32:10) Why this is a ten-year strategy, not a two-week one.Resources Mentioned:Download the Cellular Energy Protocol: https://www.younggoose.com/pages/the-mitochondrial-skin-stackAge-Associated Changes in Oxidative Stress and NAD+ Study: journals.plos.org/plosone/article/FASEB study on how methylene blue delays cellular senescence cells: faseb.onlinelibrary.wiley.com/doi/Find more from Young Goose:Use code PODCAST10 to get 10% OFF your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincare
In this episode the guys break down exactly how to look your best this summer with 30 days or less. They debate personal strategies — carb and water manipulation, peak week bodybuilding tactics, creatine loading, blood flow restriction training for arms and calves, building your abs instead of just leaning out, training rear delts and upper back for the beach, tibialis training for better looking legs, and why switching to whole foods alone will make you look visibly different in 30 days. MAPS Summer Sale — https://mapsfitnessproducts.com Code: SUMMER40 — 40% off everything (programs, bundles, mods & guides) — June 1–14 only SPONSOR Rho Nutrition (liposomal NAD+ & Glutathione) — https://www.rhonutrition.com/discount/MINDPUMP Code: MINDPUMP — 20% off everything. NAD+ raises your baseline energy without stimulants. LINKS Mind Pump Store: https://mindpumpstore.com Maps Fitness Products: https://mapsfitnessproducts.com Instagram: @mindpumpmedia 0:00 - Intro 2:02 - Adam's 30-day strategy — push carbs and volume, then taper and peak the final week 9:12 - Creatine loading for muscle fullness — why the scale going up is actually good 10:05 - Spray tans, haircuts and the real reason bodybuilders tan up 13:19 - Sal's strategy — build your abs instead of just leaning out, rear delts & upper back 20:44 - Blood flow restriction for arms and calves — a quarter inch of size in 30 days 22:10 - Justin's strategy — eliminate the extras, clean up the diet, rows and cleans for the yoke 23:43 - Why switching to whole foods alone makes you look visibly better in 30 days
Drag by 2 PM? In this Supplement Ingredient Series episode, Nurse Doza breaks down NAD+, the coenzyme your cells use to make energy (ATP), and why levels dip with age and stress. He explains how NAD+ injections at home through SHED's provider-guided telehealth program offer a convenient way to support steady all-day energy, sharper focus, and less brain fog. Try it with code DOZA40 for 40% off. Featured Partner: SHED SHED is a telehealth provider that ships physician-reviewed NAD+ at-home injection kits, so you can keep a consistent NAD+ routine without booking a clinic IV drip — exactly the kind of convenient, repeatable protocol Nurse Doza describes in this episode. Always follow the dosing and technique guidance from your SHED provider.
To Support the work of Apologia -Our newest sponsor is Dominion Wealth Strategists! -Get the NAD treatment Jeff is on, go to Ion Layer and put “IONAPOLOGIA” into the coupon code and get $100 off your first three months! -Check out Amtac Blades and use code APOLOGIA in the check out for 5% off! -You can get in touch with Heritage Defense and use coupon code “APOLOGIA” to get your first month free! -For some Presip Blend Coffee Check out our Store. -Check out the Ezra Institute
What happens when a data-driven nutrition scientist sits down with one of the wellness world's biggest advocates for whole-food living and tackles some of the most controversial nutrition debates head-on? In this powerful and nuanced conversation, Darin Olien welcomes naturopathic doctor, researcher, educator, and science communicator Dr. Matthew Nagra for an evidence-based exploration of plant protein, muscle growth, fiber, seed oils, saturated fat, nutrition misinformation, social media influencers, and the future of nutritional science. Together they unpack why outcomes matter more than mechanisms, why plant proteins perform just as well as animal proteins for strength and muscle gain, the truth about seed oils and omega-6 fats, the overwhelming evidence supporting fiber consumption, and how people can learn to evaluate nutrition claims more critically in a world flooded with misinformation. This episode is a masterclass in scientific literacy, critical thinking, and practical nutrition. What You'll Learn Why plant protein performs just as well as animal protein for muscle growth The difference between nutrition mechanisms and real-world outcomes How social media amplifies nutrition misinformation Why Dr. Nagra began challenging viral dietary myths The strongest evidence supporting plant-based nutrition What the research actually says about seed oils The truth behind omega-6 to omega-3 ratios Why beef tallow isn't the miracle food social media claims How fiber may be the most important nutrient most people ignore What the Plant-Based Diet Index reveals about longevity The Stanford twin study and what it found about plant-based diets How to become more scientifically literate in a confusing nutrition landscape Chapters 00:00:00 – Welcome to SuperLife 00:00:33 – Sponsor: Tru Niagen and the science of NAD+ 00:02:37 – Introducing Dr. Matthew Nagra 00:03:22 – Why nutrition misinformation spreads so easily 00:05:15 – Matthew's mission to bring scientific literacy to nutrition 00:06:27 – Seeing the real-world consequences of viral health advice 00:07:03 – Why social media nutrition myths affect actual patients 00:08:06 – The evolution of nutrition science over the last decade 00:08:32 – Plant protein versus animal protein: where the debate began 00:09:17 – Essential amino acids and protein quality explained 00:09:40 – Why combining plant foods solves amino acid concerns 00:09:57 – Digestibility scores and the reality of protein absorption 00:10:36 – The landmark vegan versus omnivore muscle growth studies 00:11:15 – Why outcomes matter more than mechanisms 00:11:44 – The exercise analogy that explains nutrition science 00:12:30 – Social media fearmongering around lectins, oxalates, and plants 00:13:05 – Do nutrition influencers actually believe what they promote? 00:14:27 – The dangers of extreme dietary ideology 00:15:19 – Health misinformation versus harmless misinformation 00:16:01 – Why poor dietary choices can take decades to show consequences 00:16:27 – Sponsor: Fatty15 00:20:08 – Human adaptability and delayed health consequences 00:21:29 – Darin's vision for a more plant-forward future 00:22:17 – Plant-based momentum, backlash, and social narratives 00:23:14 – Media influence and public confusion around nutrition 00:24:14 – Why "just eat more plants" remains powerful advice 00:25:09 – How Matthew helps people understand scientific research 00:25:45 – "Doctor Nagra cured my science illiteracy" 00:26:12 – The power of live nutrition debates 00:27:16 – Why real-time debates reveal weak arguments 00:27:43 – Today's hottest nutrition controversies 00:28:07 – Ultra-processed foods and the growing nuance in the discussion 00:29:01 – What actually makes a food ultra-processed? 00:29:29 – Saturated fat, butter, and beef tallow 00:29:55 – The Minnesota Coronary Experiment controversy 00:31:13 – Cherry-picking studies versus evaluating the full body of evidence 00:32:03 – Why polyunsaturated fats continue to show benefits 00:32:38 – The strongest arguments for eating more plants 00:33:01 – Why fiber may be the most powerful nutrient in nutrition 00:33:42 – Patreon break 00:35:15 – The Plant-Based Diet Index explained 00:35:51 – Swapping animal protein for plant protein and reducing mortality risk 00:36:31 – Matthew's personal journey into plant-based nutrition 00:37:28 – Losing weight and improving asthma through dietary change 00:38:23 – Going fully plant-based and staying consistent 00:39:02 – The influence of Earthlings and animal ethics 00:40:14 – Commitment, discipline, and lifestyle change 00:41:05 – Following the evidence wherever it leads 00:42:08 – Being wrong, learning, and improving scientific understanding 00:42:49 – The joy of dissecting studies and uncovering nuance 00:43:39 – Checking bias and evaluating animal-food research fairly 00:45:37 – Environmental contaminants and modern food systems 00:45:58 – Matthew's 40,000-word seed oil review 00:46:48 – How seed oils are actually processed 00:47:26 – Bleaching, refining, and common misconceptions 00:47:58 – Omega-6 fats and inflammation myths 00:48:43 – The omega-6 to omega-3 ratio debate 00:49:24 – Why increasing omega-3s matters more than avoiding omega-6s 00:50:08 – Hexane, chemical extraction, and seed oil safety 00:51:11 – Beef tallow's resurgence and why it's happening 00:52:07 – What the evidence says about saturated fat 00:52:50 – Chocolate, stearic acid, and cardiovascular health 00:55:27 – New research on plant-based diets and biological aging 00:55:56 – Meeting Stanford researcher Christopher Gardner 00:56:33 – The Stanford twin study on plant-based eating 00:57:23 – Common criticisms of the twin study 00:58:03 – Funding accusations and scientific credibility 00:59:12 – Matthew's daily routine and nutrition habits 01:00:03 – How he tracks new nutrition research every morning 01:00:47 – Training, recovery, and building muscle on plants 01:02:13 – Soccer, strength training, and athletic performance 01:03:10 – Lane Norton, nutrition debates, and professional disagreement 01:04:22 – The future of nutrition communication and public education 01:05:00 – Final thoughts on evidence, health, and helping people think critically Thank You to Our Sponsors Truniagen: Go to www.truniagen.com and use code DARINOLIEN20 at checkout for 20% off Fatty15: Get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com/DARIN and using code DARIN at checkout. Join the SuperLife Community Get Darin's deeper wellness breakdowns — beyond social media restrictions: Weekly voice notes Ingredient deep dives Wellness challenges Energy + consciousness tools Community accountability Extended episodes Join for $7.49/month → https://patreon.com/darinolien Find More from Dr. Matthew Nagra Website: drmatthewnagra.com Instagram: @dr.matthewnagra Book an Appointment Here! Download: Free Cholesterol Guide Find More from Darin Olien: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Platform & Products: superlife.com New Show: Roadmap to Happiness Key Takeaway "The most valuable nutrition skill in today's world may not be knowing what to eat—it's knowing how to think. In an age of viral misinformation, cherry-picked studies, and extreme dietary tribes, the ability to evaluate evidence, understand nuance, and focus on real-world outcomes becomes a superpower. The strongest dietary patterns consistently point in the same direction: more whole plant foods, more fiber, less dogma, and a commitment to following the evidence wherever it leads."
In an era where longevity and anti-aging advice are everywhere, it can be difficult to separate meaningful science from marketing hype. What actually works when it comes to living longer, feeling better, and maintaining peak performance as we age? In this episode, Michael Linares joins the podcast to share his insights… Michael is the CEO of Longevity Farms, a wellness company dedicated to helping people optimize performance, recovery, and long-term health. Through evidence-based supplementation, education, and a focus on cellular wellness, Michael and his team aim to help individuals improve their energy, resilience, and overall quality of life as they age. Hit play to learn more about: The "holy grail" of longevity optimization. Why mitochondrial health plays a critical role in healthy aging. The connection between cellular energy production and overall wellness. How to boost NAD, and why it matters. Michael's passion for longevity was shaped by more than 15 years of experience as a personal trainer and nurse educator, where he developed an interest in human physiology and the science of aging. Inspired by conversations with his brother Joe Linares, a firefighter-paramedic and fitness enthusiast, he began exploring emerging research on longevity and the biological processes that influence how we age. Connect with Michael: Instagram Longevity Farms Website
Today's episode starts with one of the biggest cliffhangers in recent Rizzuto Show history: Riz finally gets the results from his sleep study. Will he officially become a CPAP guy? Is he about to start "microdosing life support" every night? Or will doctors somehow discover an entirely new category of terrible sleep? The crew weighs in with equal parts concern, medical expertise they definitely don't have, and relentless roasting.Things somehow spiral into a discussion about waking up twenty times a night, cortisol overload, testosterone levels, hormone therapy, NAD shots, and the possibility that everyone on the show is slowly becoming a science experiment. Basically, if you've ever hit your 40s and wondered what happened, this conversation is for you.Then it's on to movie theater controversy as Alamo Drafthouse sparks outrage by replacing their old-school paper ordering system with QR code phone ordering. The crew debates whether phones belong anywhere near a movie screen, whether glowing screens ruin the experience, and if Elijah Wood might be the most passionate movie theater defender on Earth.Meanwhile, Riz and his wife are considering a rare date night at the movies, leading to a surprisingly intense discussion about movie choices, theater etiquette, and whether anyone should ever be playing a game on their phone during a film.In Crap On Celebrities, the gang dives into music festival drama as performers start dropping out of the America 250 celebration while Vanilla Ice somehow remains standing. There's also talk about Riot Fest's loaded lineup, Tom Morello's latest festival announcement, Violet Grohl's debut album, Willie Nelson making chart history, and upcoming movies that might actually be worth leaving the house for.The entertainment world doesn't escape unscathed either. The crew discusses Brad Pitt family drama, Nicolas Cage changing his name to avoid riding the Coppola family coattails, Toy Story 5 preparing to emotionally destroy an entire generation again, and the strange reality that kids today would rather stare at a tablet than play with actual toys.Then comes one of the day's biggest debates: the Mount Rushmore of arena rock. Queen, Journey, Van Halen, Bon Jovi, AC/DC, KISS, Led Zeppelin, Aerosmith, U2, and more all enter the argument as the crew tries to determine which bands truly deserve arena rock immortality.Add in celebrity birthdays, bizarre movie facts, festival announcements, old concert memories, and enough sarcasm to power a small city, and you've got another completely normal day with The Rizzuto Show.If you're looking for a daily comedy show packed with ridiculous conversations, pop culture commentary, music news, and the kind of friendship that only comes from years of roasting each other on the radio, this episode delivers.The Rizzuto Show remains the daily comedy show where sleep studies become comedy material, movie theater policies become national debates, and arena rock rankings become blood feuds.Thanks for making us part of your daily comedy show routine.Follow The Rizzuto Show → https://linktr.ee/rizzshow for more from your favorite daily comedy show.Connect with The Rizzuto Show Comedy Podcast online → https://1057thepoint.com/RizzShowHear The Rizz Show daily on the radio at 105.7 The Point | Hubbard Radio in St. Louis, MO.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
How CD38, PARP, and Leaky Gut Are Destroying Your NAD Levels | Dr. Andrew Salzman Your NAD is being drained by two hidden enzymes, your gut may be the starting point of every aging process in your body, and creatine does something to your mitochondria that has nothing to do with muscle. This episode rewrites what you thought you knew about longevity, anti-aging biology, and how your body actually produces and delivers energy at the cellular level. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Explore all of Wonderfeel's products at: getwonderfeel.com/dave They are gifting a complimentary 7-day Youngr™ supply (mini pouch) with every order across any of their products. The code will be DAVE, and the campaign will be active through June 6th. Host Dave Asprey sits down with Dr. Andrew Salzman, a physician, inventor, and biomedical entrepreneur with more than 30 years of experience in drug discovery and development. An alumnus of Harvard Medical School, Yale University, and Columbia University, Dr. Salzman has authored more than 170 scientific publications and holds 50 patents. He invented the original clinical-stage PARP-1 inhibitor, leading to the world's first clinical treatment for raising NAD levels and fighting cancers caused by the BRCA1 and BRCA2 genes. Genentech licensed his breakthrough technology for $600 million. His research into gastrointestinal microbiota, autoimmune disease, oxidative stress, and mitochondrial ATP production now forms the foundation of how millions of patients get treated worldwide. Dr. Salzman names the two biggest NAD drains in your body, CD38 and PARP, and explains why taking NMN or NR alone is like filling a bathtub with the drain wide open. He breaks down the formulation science behind pairing NAD precursors with CD38 blockers like hydroxytyrosol alongside PARP-reducing antioxidants like ergothioneine, and delivers a paradigm-shifting explanation of creatine as an energy distribution network inside your cells. Rather than a simple muscle supplement, creatine acts as a high-speed ATP shuttle that carries energy from your mitochondria to the precise location and moment your brain, gut, and heart need it most. You'll Learn: Why NAD declines with age and which two enzymes are primarily responsible for draining it How CD38 rises with inflammation rather than NAD levels, and what that means for your supplement strategy Why creatine is one of the most underrated anti-aging and brain optimization supplements available How creatine functions as a spatial and temporal energy delivery network for your brain, gut, and heart Why the gut may be the origin point of the entire aging process and how that cascade unfolds decade by decade How leaky gut drives systemic inflammation, crashes NAD, and accelerates biological aging throughout the body What controls tight junction integrity and how ATP, butyrate, creatine, and fasting all play a role Why most creatine supplements fail to absorb properly and what to look for in a high-quality source How to rebuild your microbiome in three to four weeks through diet alone, without antibiotics Why walking immediately after a meal may be doing more harm than good to your gut lining Thank you to our sponsors! - Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. - KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off - Pique | Go to Piquelife.com/dave for 20% off. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. Andrew Salzman, NAD depletion, CD38 inhibition, PARP inhibition, NMN supplements, creatine ATP shuttle, leaky gut aging, tight junction integrity, inflammaging, lipopolysaccharide gut, flagellin toxin, butyrate gut healing, ergothioneine, hydroxytyrosol, peroxynitrite, superoxide mitochondria, creatine energy distribution, gut origin of aging, NAD bathtub analogy, BRCA PARP inhibitor, Wonderfeel, creatine monohydrate, intestinal permeability, microbiome butyrate, selective digestive decontamination, TMAO nitric oxide Resources: • Explore all of Wonderfeel's products at: getwonderfeel.com/dave • Order Youngr™: getwonderfeel.com/dave• Order ChocoCreatin™: getwonderfeel.com/dave• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 01:12 – Introduction & BRCA Background 02:19 – DNA Damage & PARP 04:38 – Free Radicals & Oxidative Stress 11:37 – NAD & Antioxidant Defense 12:34 – CD38 & NAD Depletion 23:31 – The Gut-Aging Hypothesis 30:05 – ATP, Creatine & Energy Distribution 36:41 – Creatine as Energy Shuttle 51:09 – Microbiome & Gut Repair 59:21 – TMAO & Nitric Oxide Interference 1:03:52 – Flagellin & Gut Inflammation Research 1:09:45 – FDA & Pharmaceutical Incentives 1:16:05 – Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
In this episode the guys break down exactly when you should NOT add weight to the bar, including when you've already reached your strength ceiling, when your form isn't perfect, when you feel any pain or discomfort, after a bad night of sleep, and when you're in a calorie deficit. They also get into a study showing exercise variety predicts longevity better than exercise volume, Sal's experience with a new peptide called 5-amino-1MQ through MPHormones, TMG as a creatine-stacking supplement, and the story of Pope John Paul II's assassination attempt and the remarkable forgiveness that followed. Then they coach live callers submitted through mplivecaller.com. Sarah Beth from Mississippi on reverse dieting as a petite woman, Chelsea from Australia on training through pregnancy, Sandy from Connecticut with a 30-day check-in update, and Parker from Georgia on how to structure progression as an intermediate lifter returning to consistency. MAPS 15 BOGO — https://maps15bogo.com Buy 1 get 1 FREE — limited time (all 7 MAPS 15 programs same price) SPONSORS Rho Nutrition (liposomal NAD+ & Glutathione) — https://www.rhonutrition.com/discount/MINDPUMP Code: MINDPUMP — 20% off sitewide. Liquid liposomal delivery for cellular energy, recovery & oxidative stress support. Huel — https://huel.com/MINDPUMP Code: MINDPUMP — 15% off (new customers only). Ready-to-Drink: 35g protein, 7g fiber, 27 vitamins & minerals, no artificial sweeteners. Black Edition Powder: 40g protein. Complete nutrition for chaotic days. LMNT (electrolytes) — https://drinklmnt.com/MindPump Free 8-count sample pack with any purchase — no code needed. Citrus Salt, Raspberry Salt, Watermelon Salt & Orange Salt (2 of each). Submit a live caller question: https://mplivecaller.com Mind Pump Store: https://mindpumpstore.com Maps Fitness Products: https://mapsfitnessproducts.com Instagram: @mindpumpmedia 0:00 - Intro 2:40 - When you should NOT add weight to the bar — the full breakdown 5:23 - Reason #1: You've already hit your strength ceiling — what that looks like 11:07 - Reason #2: Your form isn't perfect — the leverage math that makes this critical 14:01 - Reason #3: You feel anything that isn't right — why every injury had a warning sign 16:19 - Reason #4: You had a bad night of sleep — the #1 predictor of injury in the data 17:47 - Reason #5: You're in a calorie deficit — why ramping intensity during a cut backfires 23:34 - Exercise variety study — more types of exercise = better longevity than more volume 29:01 - 5-amino-1MQ peptide — Sal's NP Hormones experience, NAD & energy 37:32 - TMG (betaine) — stacking with creatine for strength, power & body recomposition 41:03 - Pope John Paul II assassination attempt — forgiveness, redemption & Billy Graham story 50:08 - Meal replacement shakes as a fat loss strategy — when and how to use them correctly 56:03 - Reverse bands — why band-assisted pressing feels so different from band-resistant 1:01:38 - Caller: Sarah Beth (Mississippi) — petite woman, reverse diet, how high should she go? 1:20:35 - Caller: Chelsea (Australia) — 18 weeks pregnant, lost motivation, identity crisis 1:32:02 - Caller: Sandy (Connecticut) — 30-day check-in, big strength gains, community & letting people in 1:57:58 - Caller: Parker (Georgia) — intermediate lifter returning to consistency, how to structure progression
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