BloodLine Podcast

Presenting a NEW BloodLine podcast, “FVIII Inhibitors: The Next Chapter.” In our third episode, we speak to community members and advocates about their hopes for the future of FVIII inhibitor treatment as well as local and nationwide resources available to FVIII inhibitor patients. “FVIII Inhibitors: The Next Chapter” is a three-part podcast series looking at the current and future state of living with hemophilia A with factor VIII inhibitors. Special, huge thanks to our guests: Justin Levesque Dr. Guy Young Sue Geraghty Liz Purvis Eric Lowe Janet Brewer and Benjamin Denman BloodLine—FVIII Inhibitors: The Next Chapter is produced by me, Patrick James Lynch, and Ryan Gielen. Written by Ryan Gielen. Edited by Josh Davis. Produced at BloodStream Media's Los Angeles studio, and mixed by Michael Capuano at Icemen Sound. For more information on the podcast, visit our website at www.BloodLinePod.com. This series was produced by Believe Limited in collaboration with Genentech, the makers of HEMLIBRA® (emicizumab-kxwh). What is HEMLIBRA? HEMLIBRA is a prescription medicine used for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adults and children, ages newborn and older, with hemophilia A with or without factor VIII inhibitors. What is the most important information I should know about HEMLIBRA? HEMLIBRA increases the potential for your blood to clot. Carefully follow your healthcare provider’s instructions regarding when to use an on-demand bypassing agent or factor VIII, and the dose and schedule to use for breakthrough bleed treatment. HEMLIBRA may cause serious side effects when used with activated prothrombin complex concentrate (aPCC; FEIBA®), including thrombotic microangiopathy (TMA), and blood clots (thrombotic events). If aPCC (FEIBA®) is needed, talk to your healthcare provider in case you feel you need more than 100 U/kg of aPCC (FEIBA®) total. How should I use HEMLIBRA? • Stop (discontinue) prophylactic use of bypassing agents the day before starting HEMLIBRA prophylaxis. • You may continue prophylactic use of factor VIII for the first week of HEMLIBRA prophylaxis. What should I know about lab monitoring? HEMLIBRA may interfere with laboratory tests that measure how well your blood is clotting and may cause a false reading. Talk to your healthcare provider about how this may affect your care. The most common side effects of HEMLIBRA include: redness, tenderness, warmth, or itching at the site of injection; headache; and joint pain. These are not all of the possible side effects of HEMLIBRA. Speak to your healthcare provider for medical advice about side effects. You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at (888) 835-2555. Please see the HEMLIBRA full Prescribing Information and Medication Guide for Important Safety Information, including Serious Side Effects, here: bit.ly/2kp959s HEMLIBRA® is a registered trademark of Chugai Pharmaceutical Co., Ltd., Tokyo, Japan. The Genentech logo is a registered trademark of Genentech, Inc. © 2019 Genentech USA, Inc. All rights reserved. EMI/053019/0107e 07/19

Presenting a NEW BloodLine podcast, “FVIII Inhibitors: The Next Chapter.” In our second episode, we learn about the ten-year journey to bring HEMLIBRA® (emicizumab-kxwh) to market and take a deep look at the clinical trials of HEMLIBRA. “FVIII Inhibitors: The Next Chapter” is a three-part podcast series looking at the current and future state of living with hemophilia A with factor VIII inhibitors. Special, huge thanks to our guests: Justin Levesque Dr. Guy Young Sue Geraghty Liz Purvis Eric Lowe Janet Brewer and Benjamin Denman BloodLine—FVIII Inhibitors: The Next Chapter is produced by me, Patrick James Lynch, and Ryan Gielen. Written by Ryan Gielen. Edited by Josh Davis. Produced at BloodStream Media's Los Angeles studio, and mixed by Michael Capuano at Icemen Sound. For more information on the podcast, visit our website at www.BloodLinePod.com. This series was produced by Believe Limited in collaboration with Genentech, the makers of HEMLIBRA® (emicizumab-kxwh). What is HEMLIBRA? HEMLIBRA is a prescription medicine used for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adults and children, ages newborn and older, with hemophilia A with or without factor VIII inhibitors. What is the most important information I should know about HEMLIBRA? HEMLIBRA increases the potential for your blood to clot. Carefully follow your healthcare provider’s instructions regarding when to use an on-demand bypassing agent or factor VIII, and the dose and schedule to use for breakthrough bleed treatment. HEMLIBRA may cause serious side effects when used with activated prothrombin complex concentrate (aPCC; FEIBA®), including thrombotic microangiopathy (TMA), and blood clots (thrombotic events). If aPCC (FEIBA®) is needed, talk to your healthcare provider in case you feel you need more than 100 U/kg of aPCC (FEIBA®) total. How should I use HEMLIBRA? • Stop (discontinue) prophylactic use of bypassing agents the day before starting HEMLIBRA prophylaxis. • You may continue prophylactic use of factor VIII for the first week of HEMLIBRA prophylaxis. What should I know about lab monitoring? HEMLIBRA may interfere with laboratory tests that measure how well your blood is clotting and may cause a false reading. Talk to your healthcare provider about how this may affect your care. The most common side effects of HEMLIBRA include: redness, tenderness, warmth, or itching at the site of injection; headache; and joint pain. These are not all of the possible side effects of HEMLIBRA. Speak to your healthcare provider for medical advice about side effects. You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at (888) 835-2555. Please see the HEMLIBRA full Prescribing Information and Medication Guide for Important Safety Information, including Serious Side Effects, here: bit.ly/2kp959s HEMLIBRA® is a registered trademark of Chugai Pharmaceutical Co., Ltd., Tokyo, Japan. The Genentech logo is a registered trademark of Genentech, Inc. © 2019 Genentech USA, Inc. All rights reserved. EMI/053019/0107e 07/19

Presenting a NEW BloodLine podcast, “FVIII Inhibitors: The Next Chapter.” In our first episode, we meet patients from around the country who live with hemophilia A with factor VIII inhibitors and hear about their journeys first hand. “FVIII Inhibitors: The Next Chapter” is a three-part podcast series looking at the current and future state of living with hemophilia A with factor VIII inhibitors. Special, huge thanks to our guests: Justin Levesque Dr. Guy Young Sue Geraghty Liz Purvis Eric Lowe Janet Brewer and Benjamin Denman BloodLine—FVIII Inhibitors: The Next Chapter is produced by me, Patrick James Lynch, and Ryan Gielen. Written by Ryan Gielen. Edited by Josh Davis. Produced at BloodStream Media's Los Angeles studio, and mixed by Michael Capuano at Icemen Sound. For more information on the podcast, visit our website at www.BloodLinePod.com. This series was produced by Believe Limited in collaboration with Genentech, the makers of HEMLIBRA® (emicizumab-kxwh). What is HEMLIBRA? HEMLIBRA is a prescription medicine used for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adults and children, ages newborn and older, with hemophilia A with or without factor VIII inhibitors. What is the most important information I should know about HEMLIBRA? HEMLIBRA increases the potential for your blood to clot. Carefully follow your healthcare provider’s instructions regarding when to use an on-demand bypassing agent or factor VIII, and the dose and schedule to use for breakthrough bleed treatment. HEMLIBRA may cause serious side effects when used with activated prothrombin complex concentrate (aPCC; FEIBA®), including thrombotic microangiopathy (TMA), and blood clots (thrombotic events). If aPCC (FEIBA®) is needed, talk to your healthcare provider in case you feel you need more than 100 U/kg of aPCC (FEIBA®) total. How should I use HEMLIBRA? • Stop (discontinue) prophylactic use of bypassing agents the day before starting HEMLIBRA prophylaxis. • You may continue prophylactic use of factor VIII for the first week of HEMLIBRA prophylaxis. What should I know about lab monitoring? HEMLIBRA may interfere with laboratory tests that measure how well your blood is clotting and may cause a false reading. Talk to your healthcare provider about how this may affect your care. The most common side effects of HEMLIBRA include: redness, tenderness, warmth, or itching at the site of injection; headache; and joint pain. These are not all of the possible side effects of HEMLIBRA. Speak to your healthcare provider for medical advice about side effects. You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at (888) 835-2555. Please see the HEMLIBRA full Prescribing Information and Medication Guide for Important Safety Information, including Serious Side Effects, here: bit.ly/2kp959s HEMLIBRA® is a registered trademark of Chugai Pharmaceutical Co., Ltd., Tokyo, Japan. The Genentech logo is a registered trademark of Genentech, Inc. © 2019 Genentech USA, Inc. All rights reserved. EMI/053019/0107e 07/19

In Part 3 of BloodLine’s Hemophilia and Young Adulthood Series - our final episode - eight members of the Hemophilia Association of New Jersey (HANJ) give their perspectives on DATING & INTIMACY, how hemophilia plays a role in a young adult’s FAMILY, and what they HOPE for the future of the hemophilia community. This conversation was recorded live on January 17th at the Madison Hotel in Morristown, New Jersey and was co-hosted by BloodStream Media’s Natalie and Patrick James Lynch. Series Sponsor: Shire. Visit bleedingdisorders.com to find useful tools and resources for managing life with a bleeding disorder. Patient Organization Partner: The Hemophilia Association of New Jersey (HANJ). Learn more about HANJ and their mission by visiting http://hanj.org. National Hemophilia Foundation’s Chapter Directory. Hemophilia Federation of America’s Member Organizations Search Platform.   BloodLine is a BloodStream Media podcast series featuring deep dives into the stories and topics that matter most to the bleeding disorders community. Subscribe to The BloodLine Podcast on iTunes (http://bit.ly/BloodLinePod) or visit BloodLinePod.com to stream or subscribe via links.  Find all of BloodStream Media’s podcasts for the bleeding disorders community by visiting BloodStreamMedia.com.  

In Part 2 of BloodLine’s Hemophilia and Young Adulthood Series, eight members of the Hemophilia Association of New Jersey (HANJ) discuss PUSHING LIMITS and finding boundaries, the need for EMOTIONAL SUPPORT, various forms of PAIN MANAGEMENT, and troubling topic of SUBSTANCE ABUSE. This conversation was recorded live on January 17th at the Madison Hotel in Morristown, New Jersey and was co-hosted by BloodStream Media’s Natalie and Patrick James Lynch.   Series Sponsor: Shire. Visit bleedingdisorders.com to find useful tools and resources for managing life with a bleeding disorder. Patient Organization Partner: The Hemophilia Association of New Jersey (HANJ). Learn more about HANJ and their mission by visiting http://hanj.org. BloodLine is a BloodStream Media podcast series featuring deep dives into the stories and topics that matter most to the bleeding disorders community. Subscribe to The BloodLine Podcast on iTunes (http://bit.ly/BloodLinePod) or visit BloodLinePod.com to stream or subscribe via links.  Find all of BloodStream Media’s podcasts for the bleeding disorders community by visiting BloodStreamMedia.com.

In Part 1 of BloodLine’s Hemophilia and Young Adulthood, eight members of the Hemophilia Association of New Jersey (HANJ) weigh in on the topics of IDENTITY as someone with a bleeding disorder; DISCLOSURE in school, professional, and social settings; and TRANSITIONS, such as those from high school to college, from college into the professional world, and from singledom to marriage. This conversation was recorded live on January 17th at the Madison Hotel in Morristown, New Jersey and was co-hosted by BloodStream Media’s Natalie and Patrick James Lynch. Series Sponsor: Shire. Visit bleedingdisorders.com to find useful tools and resources for managing life with a bleeding disorder. Patient Organization Partner: The Hemophilia Association of New Jersey (HANJ). Learn more about HANJ and their mission by visiting http://hanj.org. BloodLine is a BloodStream Media podcast series featuring deep dives into the stories and topics that matter most to the bleeding disorders community. Subscribe to The BloodLine Podcast on iTunes (http://bit.ly/BloodLinePod) or visit BloodLinePod.com to stream or subscribe via links.

The BloodLine Podcast presents: von Willebrand Disease (vWD), Part 3 - The Community & The Future Patient communities have started organizing and increasing educational opportunities for people living with vWD, thanks in large part to rising awareness of the disorder around the country and the world. This episode features some profound, challenging and inspiring stories of how the vWD community is connecting, growing and changing. You'll meet patients and clinicians and hear their stories, and their perspectives on the future of vWD treatment, management, and community-building. Stream or download the episode today by visiting www.BloodLinePod.com! BloodLine is a BloodStream Media podcast series featuring deep dives into the stories that matter most. This three-episode series focuses on von Willebrand Disease, and features stories of people affected by vWD alongside interviews with clinical experts.  The series is sponsored exclusively by Shire and is intended to reduce the marginalization of people w/ vWD, increase clinical and organizational focus on vWD, and to give a voice to the diverse experiences of patients and families affected by vWD.  For more information on living with von Willebrand Disease please visit BeyondTheBleed.com

The BloodLine Podcast presents: von Willebrand Disease (vWD), Part 2 - Life with vWD vWD affects patients and their families in numerous ways. This episode, the second of three in our long-form podcast series on vWD, features powerful patient stories on the various experiences of living with the vWD, including combating stigma and the reductive outlooks on vWD. The stories run the gamut from heart breaking to uplifting and inspiring, and they'll certainly be familiar to anyone who lives with vWD or loves someone with vWD.  Stream or download the episode today by visiting www.BloodLinePod.com! BloodLine is a BloodStream Media podcast series featuring deep dives into the stories that matter most. This three-episode series focuses on von Willebrand Disease, and features stories of people affected by vWD alongside interviews with clinical experts.  The series is sponsored exclusively by Shire and is intended to reduce the marginalization of people w/ vWD, increase clinical and organizational focus on vWD, and to give a voice to the diverse experiences of patients and families affected by vWD. For more information on living with von Willebrand Disease please visit BeyondTheBleed.com 

The BloodLine Podcast presents: von Willebrand Disease (vWD), Part 1 - Diagnosis & Management What is von Willebrand Disease (vWD), how is it managed, and what is the common perception of this condition? In this podcast episode, the first of three in a new long-form audio experience on vWD, you'll hear patients and clinicians from around the world share personal stories of diagnoses, learning about vWD, and learning to manage the condition.  Stream or download the episode today by visiting www.BloodLinePod.com! BloodLine is a BloodStream Media podcast series featuring deep dives into the stories that matter most. This three-episode series focuses on von Willebrand Disease, and features stories of people affected by vWD alongside interviews with clinical experts.  The series is sponsored exclusively by Shire and is intended to reduce the marginalization of people w/ vWD, increase clinical and organizational focus on vWD, and to give a voice to the diverse experiences of patients and families affected by vWD.  For more information on living with von Willebrand Disease please visit www.BeyondTheBleed.com