inhibitors podcasts

Game Changer: Are CGRP Inhibitors the New First Line for Migraine Prevention?

Play Episode Listen Later May 7, 2025 12:29

Drs. VanderPluym and Starling review the updated position statement from the American Headache Society indicating that CGRP-targeting migraine therapies should be considered as a first-line option.

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Breast Cancer — Year in Review Series on Relevant New Datasets and Advances

Research To Practice | Oncology Videos

Play Episode Listen Later May 7, 2025 59:31

Featuring perspectives from Prof Rebecca A Dent and Dr Nancy U Lin, including the following topics: Introduction: A New Paradigm for Triple-Positive Breast Cancer? (0:00) CDK4/6 Inhibitors for HR-Positive, HER2-Negative Breast Cancer (10:06) Oral Selective Estrogen Receptor Degraders for HR-Positive, HER2-Negative Breast Cancer (21:17) Treatment of PIK3CA/PTEN/AKT-Mutated Breast Cancer (31:34) Antibody-Drug Conjugates (ADCs) for HR-Positive, HER2-Negative Breast Cancer (38:41) ADCs for HER2-Positive Breast Cancer (46:30) HER2-Targeting Tyrosine Kinase Inhibitors for HER2-Positive Breast Cancer (53:26) ADCs for Advanced Triple-Negative Breast Cancer (58:29) CME information and select publications

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Chronic Lymphocytic Leukemia | Paolo Ghia, MD, PhD

Research To Practice | Oncology Videos

Play Episode Listen Later May 3, 2025 32:31

Year in Review: Clinical Investigator Perspectives on the Most Relevant New Datasets and Advances in Chronic Lymphocytic Leukemia | Faculty Presentation 1: Current Role of Covalent Bruton Tyrosine Kinase Inhibitors and Bcl-2 Inhibitors in Chronic Lymphocytic Leukemia (CLL) — Paolo Ghia, MD, PhD CME information and select publications

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418 Maleic Acid-Based Corrosion Inhibitors: Expanding the Water Treatment Toolbox with Mike Standish

Scaling UP! H2O

Play Episode Listen Later May 2, 2025 57:45

Corrosion control is fundamental to the success of any water treatment program, but how often do we question the limitations of the tools we rely on? In this episode of Scaling UP! H2O, host Trace Blackmore welcomes back returning guest Mike Standish, Vice President of Water Additives at MFG Chemical, to explore the evolving role of maleic acid-based corrosion inhibitors in industrial water treatment. Drawing on decades of expertise, Mike shares practical insights into when — and when not — to use these innovative solutions to meet today's complex challenges. Understanding the Corrosion Control Toolbox Mike Standish opens the conversation by reframing corrosion control strategies through the lens of a toolbox analogy. With limited primary approaches — from phosphate-based to organic and metal-based chemistries — the success of corrosion management depends on matching the right tool to the right application. Mike stresses the importance of avoiding overcomplication and focusing on the fundamental chemical pathways for mild steel protection. Organic vs. Inorganic Approaches The discussion turns to the critical differences between organic and inorganic inhibitors. While inorganic phosphates remain cost-effective mainstays, organic phosphonates, including maleic acid-derived materials, offer advantages in high pH, high hardness, and oxidizing environments. Mike emphasizes that “organic” in water treatment bears no relation to natural or sustainable products, a frequent misconception among newcomers to the industry. Why Maleic Acid-Based Inhibitors Matter Maleic acid phosphonates distinguish themselves with exceptional oxidant stability, a feature increasingly necessary as continuous halogenation becomes standard practice. Mike explains the chemistry behind maleic acid derivatives and how the ability to tailor molecular structures creates flexibility for specific field conditions — such as scaling tendencies, pH control, and calcium carbonate formation risks. Best Practices for Application and Measurement Field success with maleic acid-based inhibitors hinges on proper dosage and testing. Mike shares lessons from real-world trials, emphasizing that underfeeding is a common mistake that compromises corrosion rates. Accurate differentiation between orthophosphate and phosphonate concentrations is vital for precise monitoring, and bench testing must closely simulate real-world surface-to-volume ratios to yield reliable predictions. The Future of Corrosion Control In a forward-looking discussion, Mike predicts that industry consolidation will trigger a second wave of entrepreneurial water treatment companies. His vision underscores the ongoing need for technical excellence, adaptability, and innovation in corrosion management practices as the industry evolves. This episode challenges water treatment professionals to rethink their corrosion strategies with a sharper, more informed approach. Maleic acid-based inhibitors are not a universal solution, but when applied thoughtfully, they offer powerful advantages for specific operational demands. Explore more episodes, challenge your assumptions, and lead the way in advancing our industry's standards of technical excellence. Don't forget to subscribe to Scaling UP! H2O for more expert insights in water treatment. Stay engaged, keep learning, and continue scaling up your knowledge! Timestamps 02:50 – Trace Blackmore shares a recap from previous episode. He also shares about the AWT Innovation Award 06:40 - Water You Know with James McDonald 08:00 - Upcoming Events for Water Treatment Professionals 12:38 - Welcoming back guest Mike Standish, Vice President of Water Additives – MFG Chemical 15:10 – The Value of True Industry Knowledge vs. Surface Information 23:10 – Starting the Technical Discussion: The Corrosion Control Toolbox Analogy 26:07 – Explanation of anodic vs. Cathodic protection mechanisms 37:35 – Situational Applications: When to use maleic acid-based inhibitors 40:11 – Lessons learned from field trials on dosage and corrosion control 41:28 – Importance of Accurate modeling and Surface-to-volume ratios Quotes “You going to get more than you can give” – Mike Standish “Picking the right tool for the right job” – Mike Standish "Stepping away from work for a mission trip doesn't just help others—it helps you gain a new perspective." – Mike Standish “You can't just throw a new additive into a system and hope for the best. You need data, understanding of limits, and clear expectations.” “There's going to be a second generation of AWT companies as industry consolidation continues.” Connect with Mike Standish Phone: (615) 207- 3018 Email: mike.standish@radicalpolymers.com Website: https://www.radicalpolymers.com/ LinkedIn: https://www.linkedin.com/in/mike-standish-7890627/ Click HERE to Download Episode's Discussion Guide Guest Resources Mentioned Mild Steel Corrosion Control using a Maleic-Based Inhibitor Purposely Built – Introduction of a New Copolymer for Multifunctional Applications Technical Paper Scaling UP! H2O Resources Mentioned AWT (Association of Water Technologies) Scaling UP! H2O Academy video courses Submit a Show Idea The Rising Tide Mastermind Legionella Awareness Resources 417 How To Live a Life of Significance: Insights from Aaron Walker 014 The One with Mike Standish 223 Pinks and Blues: Phosphonate Replacements 350 Polymer Perspectives: Understanding Copolymer Innovations in Water Treatment 176 The One About Tagged Polymer Technologies Water You Know with James Question: What do you call the large-diameter tube in firetube boilers where the combustion of fuel takes place? 2025 Events for Water Professionals Check out our Scaling UP! H2O Events Calendar where we've listed every event Water Treaters should be aware of by clicking HERE.

BTK Inhibitors in Multiple Sclerosis Treatment - Part 3

Neurology Minute

Play Episode Listen Later Apr 29, 2025 2:16

In the final part of this three-part series, Dr. Justin Abbatemarco and Dr. Jiwon Oh discuss how to address questions related to BTK Inhibitors with patients. Show reference: https://www.nejm.org/doi/full/10.1056/NEJMoa2415985 https://www.nejm.org/doi/full/10.1056/NEJMoa2415988

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Ep. 250 "It's an Exciting Time for Psoriasis"

Psound Bytes

Play Episode Listen Later Apr 29, 2025 30:18

"It's an exciting time. We're not just managing chronic disease. We're reimaging its trajectory" per dermatologist Dr. Mona Shahriari, Central Connecticut Dermatology and NPF Medical Board member as she discusses the latest from the AAD Annual Meeting like head-to-head studies between IL-17 and IL-23 inhibitors, early intervention for psoriasis, use of GLP-1's, new TYK2 and oral IL-23, and high impact sites with moderator Archie Franklin.

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BTK Inhibitors in Multiple Sclerosis Treatment - Part 2

Neurology Minute

Play Episode Listen Later Apr 28, 2025 3:54

In part two of this three-part series, Dr. Justin Abbatemarco and Dr. Jiwon Oh discuss the clinical trial data available in both the relapsing and progressive cohorts. Show reference: https://www.nejm.org/doi/full/10.1056/NEJMoa2415985 https://www.nejm.org/doi/full/10.1056/NEJMoa2415988

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