Podcasts about Willebrand

In this week's episode, we'll hear about new insights into PU.1-mutated agammaglobulinemia. Researchers show that haploinsufficiency of the master transcriptional regulator PU.1 causes agammaglobulinemia and dendritic cell deficiencies. These patients experience an array of infectious and non-infectious complications, but not leukemia. After that: venetoclax-based induction therapy in younger patients with AML. Venetoclax plus decitabine was associated with superior safety and non-inferior response rates compared to intensive chemotherapy. Is it time to consider lower-intensity therapy beyond older and unfit patients? Finally, a focus on venous thromboembolism. Researchers link BGAT, an enzyme pivotal to determining blood type, to risk of future VTE. They say high plasma levels of BGAT contribute to risk above and beyond what can be explained by von Willebrand factor and Factor VIII.Featured Articles:One hundred thirty-four germ line PU.1 variants and the agammaglobulinemic patients carrying themVenetoclax and decitabine vs intensive chemotherapy as induction for young patients with newly diagnosed AMLHisto–blood group ABO system transferase plasma levels and risk of future venous thromboembolism: the HUNT study

5éme épisode / 5, de la série sur la maladie de Willebrand. Episode 5 : Maladie rare – Vivre avec une maladie de Willebrand. Invité : Mr Nicolas Giraud, président d'honneur de l'Association Française des Hémophiles et référent Willebrand au sein de l'association, répond à vos questions. https://www.afh.asso.fr/page/3090093-accueil   1️⃣   Quelles sont les circonstances de découverte de la maladie de Willebrand ? [0'21 – 0'59]  ✔️ Dès la petite enfance, saignements de nez répétés. Pour plus d'informations, retrouvez notre page article : https://rarealecoute.com/maladie-de-willebrand/ 2️⃣   Comment s'est déroulé le diagnostic ? [1'00 – 2'25]  ✔️ Diagnostic posé vers 3-4 ans, après des signes inhabituels chez une aparentée (cousine). ✔️ Après orientation vers un centre spécialisé, toute la famille est diagnostiquée. 3️⃣   Quelle prise en charge a été proposée ? [2'26 -5'05]  ✔️ Interventions chirurgicales uniquement en centre spécialisé à Marseille. ✔️ Gestion des saignements difficile avant une meilleure organisation des soins. ✔️ Amélioration de la prise en charge, notamment depuis la mise en place des centres experts, avec un suivi régulier et un accès 24/7 aux spécialistes (carte d'urgence). 4️⃣   Quelles sont les motivations à devenir président d'honneur de l'Association Française des Hémophiles ? [5'05 – 6'11]  ✔️ L'engagement débute par l'implication familiale dans un comité local de l'AFH. ✔️ L'AFH est une communauté partageant des expériences similaires. ✔️ Sentiment d'appartenance et de compréhension mutuelle moteur pour un engagement profond. 5️⃣   Quels sont les actions de l'Association ? [6'11 – 8'38] ✔️ Création de la Commission Willebrand en 2007 pour soutenir et informer les patients. ✔️ Développement d'un programme d'éducation thérapeutique et de sensibilisation des professionnels de santé. ✔️ Collaboration avec d'autres commissions et implication internationale pour améliorer la prise en charge. ✔️Mise en place d'une ligne d'accompagnement accessible à tous les patients. 6️⃣   Quel message transmettre aux auditeurs ? [8'38 – 10'35]  ✔️ Pour les patients : ne pas hésiter à poser des questions et solliciter les centres spécialisés, même pour des cas moins graves. ✔️ Pour les professionnels : référer aux centres spécialisés en cas de doute.   L'équipe : Virginie Druenne – Ambassadrice RARE à l'écoute Cyril Cassard – Journaliste/Animation Hervé Guillot - Production Crédits : Sonacom ******************************************* À propos : "RARE à l'écoute" est un podcast dédié à la sensibilisation aux maladies rares et au soutien des personnes touchées par ces affections. Créé par un groupe passionné de professionnels de la santé, le podcast vise à informer les professionnels de santé et fournissant des informations sur les dernières avancées médicales et scientifiques dans le domaine des maladies rares, et inspirer les patients et leurs proches en partageant des histoires de courage et de persévérance. Contenu : 

Potential Medicaid cuts are looming that could affect our community. Hear how you can take action! We also have exciting news about a clinical trial for von Willebrand's disease and a special community story from Kayla Klein and her mother, Nancy Rodgers. Plus, Patrick has some fantastic updates from the WFH's Comprehensive Care Summit in Dubai.    Presenting Sponsor: Takeda, visit bleedingdisorders.com to learn more.   Show Notes: Subscribe: The BloodStream Podcast   Medicaid Cuts - Take Action Today!   Please call or email the offices you visited in March and remind your lawmakers that Medicaid is a lifeline: ask them to reject Medicaid funding cuts and other policies that would reduce coverage and disrupt care. For email, contact the staffer you met with at Washington Days (check your sent mail for the thank you notes). If you no longer have contact information for your lawmakers' offices, you can call the Capitol switchboard at 202.224.3121 and ask them to connect you. Say or email:   I am [calling/emailing] as a member of the bleeding disorders community and as a constituent to ask you to reject cuts to federal Medicaid funding. I am relying on you, as my Senator/Representative in Congress, to protect Medicaid from funding cuts and other policies that would reduce coverage and care.    Medicaid covers life-sustaining treatment and care for up to one-third of the bleeding disorders community. Without Medicaid, low-income people with bleeding disorders will have no access to the regular care they need to prevent or treat painful, debilitating, and potentially life-threatening bleeding episodes. People will experience preventable health complications – and overall healthcare costs will rise.   Please stand with the bleeding disorders community and so many others who rely on Medicaid, and reject cuts to this program that provides essential coverage to vulnerable individuals across the country.   ** Hemab Therapeutics Announces Start of Velora Pioneer, a Phase 1/2 Clinical Trial Investigating HMB-002 for the Treatment of Von Willebrand Disease: Press Release   More information about the vWD clinical trial participation Connect with BloodStream Media: BloodStreamMedia.com BloodStream on Facebook  BloodStream on X/Twitter

4éme épisode / 5, de la série sur la maladie de Willebrand. Episode 4 : Maladie rare – Prendre en charge une maladie de Willebrand Invité : Pr Antoine Rauch, PU-PH au sein de l'Institut d'hématologie et transfusion au CHU de Lille, clinicien du centre de référence coordonnateur de la maladie de Willebrand de la filière MHEMO et membre du groupe de rédacteurs du PNDS sur la maladie de Willebrand. https://biologiepathologie.chu-lille.fr/instituthematologie/  https://mhemo.fr/   1️⃣   Quels sont les enjeux de la prise en charge de la maladie de Willebrand ? [0'30 – 1'15]  ✔️ Une prise en charge par des professionnels des centres experts dédiés à la maladie. ✔️ Traitement personnalisé et adapté à la sévérité des symptômes en raison de l'hétérogénéité de la maladie.  Pour plus d'informations, retrouvez notre page article : https://rarealecoute.com/maladie-de-willebrand/ 2️⃣   Quels centres sont impliqués ? [1'16 – 2'38]  ✔️ Filière MHEMO regroupant les centres spécialisés pour les maladies hémorragiques rares. ✔️ Centres de référence, pôles d'expertise, assurant un rôle de recours et d'innovation. ✔️ Centres de compétences, structures de proximité pour le suivi des patients. 3️⃣   Quelle prise en charge proposer ? [2'39 -4'22]  ✔️ Traitement ponctuel pour stopper ou prévenir un saignement (chirurgie, accouchement). ✔️ Prévention des saignements graves par un traitement régulier, principalement pour les formes sévères (type 3). ✔️ Gestion spécifique de certains saignements (règles abondantes, hémorragies digestives) avec des traitements adjuvants. 4️⃣   Quels conseils et quels accompagnements préconiser pour les patients ? [4'22 – 5'06]  ✔️ Dépistage de l'anémie et d'une carence en fer. ✔️ AINS contre-indiqués. ✔️ Vaccins selon calendrier vaccinal, avec précautions  ✔️ Activité physique évaluée au cas par cas. 5️⃣   Quel suivi leur proposer ? [5'07 – 6'19]  ✔️ Adaptation du suivi en fonction de la sévérité clinique et de l'évolution du profil hémorragique. ✔️ Réévaluer périodiquement la sévérité du phénotype hémorragique, surtout pour les types 1 et 2. ✔️ Préparation pour les situations à risque (chirurgies, grossesses) afin d'assurer une prise en charge adaptée. 6️⃣   Quels sont les besoins non couverts et les perspectives de recherche dans la maladie de Willebrand ? [6'19 – 7'42]  ✔️ Faible recours à la prophylaxie en raison de l'hétérogénéité de la maladie et de la sous-estimation de son impact sur la qualité de vie. ✔️ Options thérapeutiques actuelles bien connues. ✔️ Développement de nouveaux traitements prophylactiques.   L'équipe : Virginie Druenne – Ambassadrice RARE à l'écoute Cyril Cassard – Journaliste/Animation Hervé Guillot - Production Crédits : Sonacom ***************************************** À propos : "RARE à l'écoute" est un podcast dédié à la sensibilisation aux maladies rares et au soutien des personnes touchées par ces affections. Créé par un groupe passionné de professionnels de la santé, le podcast vise à informer les professionnels de santé et fournissant des informations sur les dernières avancées médicales et scientifiques dans le domaine des maladies rares, et inspirer les patients et leurs proches en partageant des histoires de courage et de persévérance. Contenu : 

3ème épisode / 5, de la série sur la maladie de Willebrand. Episode 3 : Maladie rare – La maladie de Willebrand, le point de vue du gynécologue. Invitée : Dr Lise Duranteau, endocrinologue et gynécologue, cheffe du service de gynécologie médicale de l'hôpital Bicêtre du groupe hospitalier AP-HP Paris Saclay, et praticien référent de l'unité GYNHEMO rattachée au centre de référence des pathologies gynécologiques rares. https://hopital-bicetre.aphp.fr/gynecologie/gynecologie-medicale/    1️⃣   Dans quelles circonstances suspecter une maladie de Willebrand lors de consultations en gynécologie ? [0'32 – 2'02] ✔️ Règles abondantes dès les premières menstruations, souvent sous-estimées ou banalisées. ✔️Difficulté à évaluer l'abondance des saignements, en particulier chez les adolescentes. ✔️Importance d'une sensibilisation des jeunes filles et des professionnels de première ligne pour favoriser un diagnostic précoce. Pour plus d'informations, retrouvez notre page article : https://rarealecoute.com/maladie-de-willebrand/ 2️⃣   Quelle est la conduite à tenir en cas de suspicion de cette maladie rare ? [2'03 – 3'44] ✔️ Réaliser un bilan d'hémostase incluant dosage de l'antigène et de l'activité Willebrand. ✔️ En cas d'anomalie ou de forte suspicion clinique, orienter vers un centre expert d'hémostase. ✔️ Ne pas exclure le diagnostic même si le bilan est normal ; rechercher d'autres signes hémorragiques et antécédents familiaux. 3️⃣   Quels diagnostics différentiels évoquer d'un point de vue gynécologique ? [3'44 -5'58] ✔️ Chez une femme adulte : suspicion de lésions utérines (fibromes, polypes, adénomyose...), d'hypertrophie de l'endomètre... ✔️ Chez une adolescente : trouble du cycle menstruel, cause iatrogène... 4️⃣   Comment s'opère la coordination des soins entre gynécologue et médecin de l'hémostase ? [5'59 – 7'39] ✔️ Collaboration dès le diagnostic, puis suivi partagé et adapté sur le long terme. ✔️ Le centre d'hémostase assure le plus souvent l'annonce diagnostique, l'éducation thérapeutique, la remise de la carte de soins et d'urgence, l'enquête familiale. 5️⃣   Quels conseils transmettre aux patientes concernées ? [7'40 – 9'27] ✔️ Éducation thérapeutique : gestion des médicaments, des saignements, des antalgiques. ✔️ Suivi gynécologique et coordination avec le médecin de l'hémostase, notamment en cas de grossesse. ✔️ Accompagnement psychologique, si la qualité de vie est impactée.   L'équipe : Virginie Druenne – Ambassadrice RARE à l'écoute Cyril Cassard – Journaliste/Animation Hervé Guillot - Production Crédits : Sonacom *************************************** À propos : "RARE à l'écoute" est un podcast dédié à la sensibilisation aux maladies rares et au soutien des personnes touchées par ces affections. Créé par un groupe passionné de professionnels de la santé, le podcast vise à informer les professionnels de santé et fournissant des informations sur les dernières avancées médicales et scientifiques dans le domaine des maladies rares, et inspirer les patients et leurs proches en partageant des histoires de courage et de persévérance. Contenu :

Eine Musikfirma aus Paderborn erobert die Welt – so könnte man die Geschichte von IMAscore umschreiben. Das Studio, das mittlerweile weit mehr ist als nur eine Kompositionsschmiede, ist in der internationalen Freizeitparkwelt fest verankert. Inzwischen erstellt das Team aus NRW nicht nur Musik für Trailer und Filme, sondern bietet mit der Tochterfirma IMAmotion auch komplette Themendesigns an. Jüngst gelang es, mit der Beauftragung für die Musik des Epic-Universe-Themenparks in Orlando einen ganz großen Fisch an Land zu ziehen. Wir haben Chef Xaver Willebrand auf der IAAPA Expo Europe in Amsterdam getroffen und mit ihm über das Business gesprochen.

2ème épisode / 5, de la série sur la maladie de Willebrand. Episode 2 : Maladie rare – Diagnostiquer une maladie de Willebrand Invité : Pr Yohann Repessé, hématologue, chef du service d'hématologie biologique du CHU de Caen Normandie, coordonnateur du site constitutif du centre de référence de la maladie de Willebrand de la filière MHEMO, et membre du groupe de rédacteurs du PNDS sur la maladie de Willebrand. https://www.chu-caen.fr/centres/maladie-de-willebrand/  https://mhemo.fr/    1️⃣   Quelles sont les circonstances de diagnostic de la maladie de Willebrand ? [0'30 – 1'48] ✔️ Symptômes hémorragiques : épistaxis, gingivorragies, bleus faciles et saignements prolongés. ✔️ Bilan de coagulation, notamment avant une chirurgie ou du fait d'antécédents familiaux. Pour plus d'informations, retrouvez notre page article : https://rarealecoute.com/maladie-de-willebrand/ 2️⃣   Comment s'effectue le diagnostic de cette maladie rare ? [1'49 – 2'44] ✔️ Dosage du facteur Willebrand et de son activité : déficit de quantité ou de fonction. ✔️ Examens complémentaires pour qualifier plus finement la maladie. 3️⃣   Quels diagnostics différentiels écarter ? [2'44 -3'42] ✔️ Rares formes acquises de la maladie de Willebrand, hémophilie A et pseudo-maladie de Willebrand (anomalie des plaquettes). 4️⃣   Quels conseils génétiques proposer aux patients diagnostiqués ? [3'43 – 5'09] ✔️ Information sur la maladie et les risques de transmission. Nécessité d'une enquête familiale. 5️⃣   À qui adresser les patients atteints de la maladie de Willebrand ? [5'10 – 6'13] ✔️Orientation vers des centres experts pour le diagnostic, le suivi, et la prise en charge en cas de chirurgie ou d'accident.   L'équipe : Virginie Druenne – Ambassadrice RARE à l'écoute Cyril Cassard – Journaliste/Animation Hervé Guillot - Production Crédits : Sonacom *********************************************** À propos : "RARE à l'écoute" est un podcast dédié à la sensibilisation aux maladies rares et au soutien des personnes touchées par ces affections. Créé par un groupe passionné de professionnels de la santé, le podcast vise à informer les professionnels de santé et fournissant des informations sur les dernières avancées médicales et scientifiques dans le domaine des maladies rares, et inspirer les patients et leurs proches en partageant des histoires de courage et de persévérance. Contenu :

1er épisode / 5, de la série sur la maladie de Willebrand. Episode 1 : Maladie rare – Qu'appelle-t-on maladie de Willebrand ? Invitée : Pr Sophie Susen, chef de l'Institut d'hématologie et de transfusion du CHU de Lille, coordinatrice de la filière MHEMO, filière des maladies rares de l'hémostase, et du centre de référence coordonnateur de la maladie de Willebrand, qui ont contribué au PNDS sur la maladie de Willebrand. https://biologiepathologie.chu-lille.fr/instituthematologie/ https://mhemo.fr/    1️⃣   Qu'appelle-t-on maladie de Willebrand ? [0'32 – 2'31] ✔️ Déficit quantitatif ou qualitatif du facteur Willebrand, essentiel pour la coagulation sanguine. ✔️ Trois types principaux : I (déficit modéré), II (déficit fonctionnel) et III (déficit complet). ✔️ Elle touche environ 1 personne sur 1 000, les formes symptomatiques nécessitant un traitement sont plus rares, environ 1 personne sur 10 000. Pour plus d'informations, retrouvez notre page article : https://rarealecoute.com/maladie-de-willebrand/ 2️⃣   Quelle est la physiopathologie de cette maladie rare ? [2'32 – 3'42] ✔️ Anomalie génétique du gène du facteur Willebrand. ✔️La maladie se révèle par des saignements, à différents âges et dans diverses situations (saignements muqueux, postopératoires). ✔️ Le type III se manifeste dès l'enfance avec des saignements graves. 3️⃣   Quel tableau clinique doit faire suspecter la maladie de Willebrand ? [2'43 -4'59] ✔️ Saignements variés (muqueux, ORL, gynécologiques, gastro-intestinaux) et articulaires (formes graves). ✔️ Circonstances de découverte : symptômes de saignements, bilan de coagulation préopératoire, antécédents familiaux. 4️⃣   Quelle est l'utilité d'établir un score hémorragique pour les patients concernés ? [4'59 – 6'21] ✔️ Permet d'objectiver la fréquence des saignements, justifie une exploration approfondie et la recherche de la maladie de Willebrand. 5️⃣   À qui adresser les patients en cas de suspicion de la maladie de Willebrand ? [6'22 – 7'26] ✔️Orientation vers un centre de référence pour un diagnostic précis et une prise en charge adaptée.   L'équipe : Virginie Druenne – Ambassadrice RARE à l'écoute Cyril Cassard – Journaliste/Animation Hervé Guillot - Production Crédits : Sonacom ******************************************** À propos : "RARE à l'écoute" est un podcast dédié à la sensibilisation aux maladies rares et au soutien des personnes touchées par ces affections. Créé par un groupe passionné de professionnels de la santé, le podcast vise à informer les professionnels de santé et fournissant des informations sur les dernières avancées médicales et scientifiques dans le domaine des maladies rares, et inspirer les patients et leurs proches en partageant des histoires de courage et de persévérance. Contenu :

Le groupe sanguin pourrait influencer le risque de développer un cancer et la mortalité associée en raison de divers facteurs biologiques, immunologiques et génétiques. Plusieurs études ont exploré cette corrélation et ont mis en évidence des différences entre les groupes sanguins A, B, AB et O concernant certaines formes de cancer.1. Influence des antigènes du groupe sanguinLes groupes sanguins sont définis par la présence ou l'absence d'antigènes spécifiques (A, B, AB ou O) à la surface des globules rouges et d'autres cellules du corps, y compris celles des tissus épithéliaux, où se développent de nombreux cancers.- Le groupe A est associé à un risque accru de plusieurs cancers, notamment le cancer gastrique. Une étude a suggéré que l'antigène A pourrait favoriser l'adhésion de cellules cancéreuses et leur propagation.- Le groupe O, à l'inverse, semble offrir une protection relative contre certains types de cancer, notamment l'estomac et le pancréas.- Les groupes B et AB présentent des risques intermédiaires, bien que des études soient encore nécessaires pour confirmer ces associations.2. Lien avec les marqueurs inflammatoires et l'immunitéL'inflammation chronique est un facteur clé du développement tumoral. Le groupe sanguin pourrait influencer la réponse inflammatoire et le système immunitaire :- Les individus de groupe O auraient des niveaux plus bas de facteur von Willebrand, une protéine impliquée dans la coagulation et liée à l'inflammation. Cela pourrait expliquer leur risque moindre de thrombose et d'inflammation, deux éléments qui favorisent la croissance tumorale.- Les personnes de groupe A ou B peuvent avoir une plus grande susceptibilité aux maladies inflammatoires chroniques, qui sont des facteurs de risque pour certains cancers (comme les cancers du côlon et de l'estomac).3. Risque de métastases et survieCertaines recherches ont suggéré que le groupe sanguin pourrait aussi jouer un rôle dans la progression du cancer :- Le groupe O est souvent associé à une meilleure réponse immunitaire, ce qui pourrait limiter la progression des tumeurs.- Le groupe A, en revanche, pourrait favoriser une moindre détection des cellules tumorales par le système immunitaire, augmentant ainsi le risque de métastases.4. Études et conclusionsDes études épidémiologiques ont mis en évidence des différences significatives entre les groupes sanguins et le risque de certains cancers. Par exemple, une méta-analyse de 2015 a montré que le groupe A était plus fréquemment associé aux cancers digestifs, tandis que le groupe O présentait un risque réduit pour certains d'entre eux.Cependant, bien que des associations existent, le groupe sanguin ne constitue qu'un facteur parmi d'autres dans le développement du cancer, aux côtés de la génétique, du mode de vie et de l'environnement. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Today's podcast episode focuses on the management of complications associated with Waldenström's macroglobulinemia (WM), featuring expert insights from the 12th... The post Managing complications associated with WM: Bing-Neel syndrome, acquired von Willebrand disease, & more! appeared first on VJHemOnc.

Picture this: you're on the admit shift on a Tuesday morning, and your next patient is a 6-month-old Doberman for routine neutering. Is there anything you'd be particularly worried about before surgery? Is there anything you'd discuss with the client or any tests you'd speak to your vet about? Dobermans are a classic breed affected by von Willebrand's disease, which is a disease that sits somewhere between thrombocytopenia and coagulopathy. If they have it, bleeding is a very real risk. Thankfully, if we know beforehand, we can implement strategies to manage the patient's disease and prevent severe haemorrhage. That starts with understanding von Willebrand's disease and how it works, which is exactly what we're covering in this episode of the Medical Nursing Podcast. ---

 N-acetyl cysteine (NAC) shows promise for heart attack preventionHeart attacks and strokes are a leading cause of death in developed countries - accounting for ~20% of all deaths in the U.S. Frequently, heart attacks and strokes are caused by blood clots (blood platelets that form when they are not needed, causing a narrowing/blockage of blood vessels) formed through arterial thrombosis. Current antiplatelet agents (e.g., aspirin) are effective but can increase major bleeding risk. As such, there is a growing need to prevent arterial thrombosis different from antiplatelet agents.A recent study published in Arteriosclerosis, Thrombosis, and Vascular Biology investigated the potential of NAC as an agent to prevent arterial thrombosis. Utilizing both [cell-based] human blood models and mouse (in vitro) models, the research demonstrated that NAC significantly delayed and even prevented thrombus formation dose-dependently without increasing bleeding risks.Findings:*NAC treatment extended clot formation times by up to 3.7 times compared to controls in the human blood [cell] model.*NAC entirely inhibited platelet aggregation and occlusive clot formation at higher doses than the above point in the cell model.*A 400 mg/kg (via injection in rodents) dose of NAC in mice effectively prevented arterial occlusion post-injury.*Lower doses (200 mg/kg - via injection in rodents) of NAC reduced clot stability, suggesting working as both an acute and preventative clotting therapy.The study showed that NAC interferes with von Willebrand factor (a large protein crucial for blood clotting) activity. NAC acts against VWF rather than platelets to prevent clot formation. Thus, providing a safer alternative to traditional antiplatelet drugs that carry higher bleeding risks. Support the Show.

On this episode, Patrick James Lynch honors the late Neil Frick, Senior VP for Medical Programs at the National Bleeding Disorders Foundation, recognizing his invaluable two-decade contribution to the bleeding disorders community. We also discuss hemophilia B gene therapy with Dr. Mark Redding, focusing on unique clinical trial designs and the role of steroids. Additionally, Makenna Dietrich shares her journey in bleeding disorder advocacy. The episode includes updates from Star Therapeutics on subcutaneous therapy for von Willebrand disease and insights on closing racial health equity gaps in the US. We also invite you to help pick a new BloodStream “theme song”.    Presenting Sponsor: Takeda, visit bleedingdisorders.com to learn more.   Show Notes: Subscribe: The BloodStream Podcast   Hemophilia Uncensored Social Media: Instagram & TikTok    Star Therapeutics Presents Clinical Data for VGA039, a Subcutaneous Therapy for the Treatment of Von Willebrand Disease (VWD) How the U.S. can close longstanding racial health equity gaps Visit BEQVEZ.com to learn more about gene therapy, sign up for additional information, and listen to real patients who are now living differently.   It's a Whole New World Gene Therapy Segment brought to you by CSL Behring, which now has a first-of-its-kind hemophilia B treatment. Visit BeyondHemB.com or download B SUPPORT wherever you get your apps for more information.   Connect with BloodStream Media: BloodStreamMedia.com BloodStream on Facebook  BloodStream on Twitter   

In this week's podcast we'll discuss another step forward in stamping out high-risk myeloma. Then we'll hear about the plasmin-cleaved von Willebrand factor, or VWF, in microthrombosis. Finally we'll hear about new insights into the origins of sickle cell pain. Featured Articles:Daratumumab, carfilzomib, lenalidomide, and dexamethasone with tandem transplant for high-risk newlydiagnosed myelomaPlasmin-cleaved von Willebrand factor as a biomarker for microvascular thrombosisSickle cell disease iPSC-derived sensory neurons exhibit increased excitability and sensitization to patientplasma

About our guest … Dr. Lasky joined the Cure the Kids Foundation in 2017. He attended medical school at the University of Illinois in Chicago and did his pediatric residency at the University of Chicago. He completed his Pediatric Hematology Oncology fellowship at UCLA in 2006 and was director of the Pediatric Neuro-Oncology Program at UCLA until 2009 when he moved to Harbor-UCLA Medical Center in Torrance, CA, and was named Chief of the Division of Pediatric Hematology Oncology. While there, Dr. Lasky became involved with a number of clinical trials for patients with bleeding disorders (including hemophilia and von Willebrand disease) as well as sickle cell anemia. While continuing to have research interests in pediatric brain tumors and immunology, he also is interested in running and developing clinical trials for patients with bleeding disorders and sickle cell anemia. Dr. Lasky is a member of several professional societies including the Children's Oncology Group, Society for Neuro-Oncology, the American Society of Hematology, and the American Academy of Pediatrics. He enjoys watching sports, reading, music, and outdoor activities with his family. In September of 2022, Dr. Lasky is now the Medical Director at Cure 4 The Kids (C4K).

In this week's episode we'll discuss the findings from a study assessing the utility of free light chain mass spectrometry in AL amyloidosis, learn more about distinct single-cell RNA-sequencing signatures of bone marrow T cells of AML patients in remission after an allogeneic stem cell transplant, and discuss why von Willebrand factor clearance is critical for the protective effect of ADAMTS13 in mice with sickle cell anemia.Articles featured in this episode: Clearance of VWF by hepatic macrophages is critical for the protective effect of ADAMTS13 in sickle cell anemia mice Complete responses in AL amyloidosis are unequal: the impact of free light chain mass spectrometry in AL amyloidosisThe remission status of patients with AML post-alloSCT is associated with a distinct single-cell bone marrow T-cell signature 

“Men can have vWD and women can have hemophilia, I'll say it again -” Hanna is a passionate advocate within the Bleeding Disorders Community. In today's day and age - stating things that are true is important. Hanna has led the way since youth in progressing conversations, and acting as a voice for those unable to voice their struggle.    FLOW is straight talk about extreme periods, with new episodes the second Thursday of each month. Tune in for tips for self study, shared discoveries and to expand menstrual awareness.    Program Notes:   Guest + Links Mentioned in this Episode: Hanna Beary  Better You Know: https://www.cdc.gov/ncbddd/blooddisorders/women/materials/ NBDF's Victory for Women with Bleeding Disorders Bleeding DIsorders of the Heartland Bad Blood - Documentary Ricky Ray Relief Act National Library of Medicine: Ricky Ray Relief Act   How's Your Flow? We wanna know (Calendly link): https://calendly.com/flowtalk/flow-talk-period-pain-stories   HOST: Jessica RIchmond Website: jrich.online IG, @jessicalaurenrichmond  Twitter @geniuspills    HOST: Sarah Watson Website: sarahwatsonlpc.com Podcast: Behind The Bedroom Door Facebook: @sarahwatsonlpcsextherapy IG @swsxtherapy Twitter @swsextherapy   FLOW is sponsored by Takeda, the manufacturer of a treatment for adults with von Willebrand disease. To see if this treatment might be right for you and your needs, visit: https://ssshare.it/2rnK    Connect with BloodStream Media: Find all of our bleeding disorders podcasts on  BloodStreamMedia.com BloodStream on Facebook  BloodStream on Twitter    Check out Believe Limited's Other Work: BloodFeed: bloodfeed.com Bombardier Blood: bombardierblood.com Hemophilia: The Musical: breakingthroughhemophilia.com My Beautiful Stutter: mybeautifulstutter.com/ Stop The Bleeding!: stbhemo.com Teen Impact Awards: teenimpactawards.com The Science Fair: thesciencefair.org

In this episode of FLOW, join hosts Jessica and Sarah and Amy Board from BloodStream Media for an engaging conversation about the challenges and experiences of women with bleeding disorders. The impact of bleeding disorders on menstrual health is multifaceted and profound, affecting physical health, emotional well-being, and quality of life. Amy Board vividly brings out this impact through personal stories and experiences, offering listeners valuable insights into the world of diagnosis and treatment blockers for menstruators in the bleeding disorders community.  FLOW is straight talk about extreme periods, with new episodes the second Thursday of each month. Tune in for tips for self study, shared discoveries and to expand menstrual awareness.  Program Notes: Guest + Episode Links: MASAC Documents (via NHF) FAIR - Coalition for Women with Bleeding Disorders Study on Red Hair and Menstrual Bleeding Bloodstream Podcast Amy Board on Instagram   How's Your Flow? We wanna know (Calendly link): https://calendly.com/flowtalk/flow-talk-period-pain-stories   HOST: Jessica RIchmond Website: jrich.online IG, @jessicalaurenrichmond  Twitter @geniuspills    HOST: Sarah Watson Website: sarahwatsonlpc.com Podcast: Behind The Bedroom Door Facebook: @sarahwatsonlpcsextherapy IG @swsxtherapy Twitter @swsextherapy   FLOW is sponsored by Takeda, the manufacturer of a treatment for adults with von Willebrand disease. To see if this treatment might be right for you and your needs, visit: https://ssshare.it/2rnK    Connect with BloodStream Media: Find all of our bleeding disorders podcasts on  BloodStreamMedia.com BloodStream on Facebook  BloodStream on Twitter    Check out Believe Limited's Other Work: BloodFeed: bloodfeed.com Bombardier Blood: bombardierblood.com Hemophilia: The Musical: breakingthroughhemophilia.com My Beautiful Stutter: mybeautifulstutter.com/ Stop The Bleeding!: stbhemo.com Teen Impact Awards: teenimpactawards.com The Science Fair: thesciencefair.org  

What is Flooding? What is tranexamic acid? What is a chromogenic essay? What is an MMB? What is the PBAC? And Who would be the douchiest of all douchebags? Answers to all this and more on January's FLOW with Jeanette Jones.   Jeanette Jones is a menstrual health advocate and a connoisseur in tracking for improved healthcare. Jeanette is passionate about empowering individuals to take control of their menstrual health experience. Her down-to-earth approach and wealth of knowledge make her a valuable resource for anyone looking to gain a deeper understanding of their menstrual cycle and improve their healthcare decisions.   FLOW is straight talk about extreme periods, with new episodes the second Thursday of each month. Tune in for tips for self study, shared discoveries and to expand menstrual awareness.    Program Notes:   Guest Info: Jeannette Jones  Jeanette Jones Linkedin: https://www.linkedin.com/in/jeanette-jones-ok Menstrual Tracking Logs: https://www.hemophiliafed.org/resource/menstruation-tracking/ Tranexamic Acid info: https://www.ncbi.nlm.nih.gov/books/NBK532909/   How's Your Flow? We wanna know (Calendly link): https://calendly.com/flowtalk/flow-talk-period-pain-stories   HOST: Jessica RIchmond Website: jrich.online IG, @jessicalaurenrichmond  Twitter @geniuspills    HOST: Sarah Watson Website: sarahwatsonlpc.com Podcast: Behind The Bedroom Door Facebook: @sarahwatsonlpcsextherapy IG @swsxtherapy Twitter @swsextherapy   FLOW is sponsored by Takeda, the manufacturer of a treatment for adults with von Willebrand disease. To see if this treatment might be right for you and your needs, visit: https://ssshare.it/2rnK    Connect with BloodStream Media: Find all of our bleeding disorders podcasts on  BloodStreamMedia.com BloodStream on Facebook  BloodStream on Twitter    Check out Believe Limited's Other Work: BloodFeed: bloodfeed.com Bombardier Blood: bombardierblood.com Hemophilia: The Musical: breakingthroughhemophilia.com My Beautiful Stutter: mybeautifulstutter.com/ Stop The Bleeding!: stbhemo.com Teen Impact Awards: teenimpactawards.com The Science Fair: thesciencefair.org  

Gillian MacSpurr, an experienced running coach from the UK, joins the conversation to shed light on her personal journey with endometriosis. Her transformation from a non-athlete to a dedicated runner highlights the profound impact of movement on overall well-being. With her emphasis on personalized approaches to fitness, Gillian's insights resonate with FLOW's focus on self-advocacy and proactive healthcare decisions. Her story serves as an inspiration for individuals navigating reproductive health challenges as she showcases the power of listening to one's body and embracing a holistic approach to health and wellness!   FLOW is straight talk about extreme periods, with new episodes the second Thursday of each month. Tune in for tips for self study, shared discoveries and to expand menstrual awareness.    Program Notes:   Guest Info: GILLIAN MacSpurr Website: https://gmacspurr.com/links/ IG: https://www.instagram.com/gmacspurr_coaching/ Facebook: https://www.facebook.com/gmacspurrcoaching/   How's Your Flow? Calendly link: https://calendly.com/flowtalk/flow-talk-period-pain-stories   HOST: Jessica RIchmond Website: jrich.online IG, @jessicalaurenrichmond  Twitter @geniuspills    HOST: Sarah Watson Website: sarahwatsonlpc.com Podcast: Behind The Bedroom Door Facebook: @sarahwatsonlpcsextherapy IG @swsxtherapy Twitter @swsextherapy   FLOW is sponsored by Takeda, the manufacturer of a treatment for adults with von Willebrand disease. To see if this treatment might be right for you and your needs, visit: https://ssshare.it/2rnK    Connect with BloodStream Media: Find all of our bleeding disorders podcasts on  BloodStreamMedia.com BloodStream on Facebook  BloodStream on Twitter    Check out Believe Limited's Other Work: BloodFeed: bloodfeed.com Bombardier Blood: bombardierblood.com Hemophilia: The Musical: breakingthroughhemophilia.com My Beautiful Stutter: mybeautifulstutter.com/ Stop The Bleeding!: stbhemo.com Teen Impact Awards: teenimpactawards.com The Science Fair: thesciencefair.org  

Boston-based Sexvangelicals have made it their mission to cultivate self-compassion while navigating through the complexities of sex education in a religious context. Empower yourself with knowledge about menstruation and challenge the stigma in your religious community on this month's FLOW.   FLOW is straight talk about extreme periods, with new episodes the second Thursday of each month. Tune in for tips for self study, shared discoveries and to expand menstrual awareness.    Program Notes:   Guest Info: Sexvangelicals Website https://www.sexvangelicals.com/ IG: https://www.instagram.com/sexvangelicals/ Podcast: https://podcasts.apple.com/us/podcast/sexvangelicals/   How's Your Flow? Calendly link: https://calendly.com/flowtalk/flow-talk-period-pain-stories   HOST: Jessica RIchmond Website: jrich.online IG, @jessicalaurenrichmond  Twitter @geniuspills    HOST: Sarah Watson Website: sarahwatsonlpc.com Podcast: Behind The Bedroom Door Facebook: @sarahwatsonlpcsextherapy IG @swsxtherapy Twitter @swsextherapy   FLOW is sponsored by Takeda, the manufacturer of a treatment for adults with von Willebrand disease. To see if this treatment might be right for you and your needs, visit: https://ssshare.it/2rnK    Connect with BloodStream Media: Find all of our bleeding disorders podcasts on  BloodStreamMedia.com BloodStream on Facebook  BloodStream on Twitter    Check out Believe Limited's Other Work: BloodFeed: bloodfeed.com Bombardier Blood: bombardierblood.com Hemophilia: The Musical: breakingthroughhemophilia.com My Beautiful Stutter: mybeautifulstutter.com/ Stop The Bleeding!: stbhemo.com Teen Impact Awards: teenimpactawards.com The Science Fair: thesciencefair.org  

“I really think that if we got in there earlier, we could really shape things differently for (teens) and for those that care for (teens) too.”  This month, Flow with Dr. Abraham and effective strategies for discussing puberty with teens. Plus, get reminders of the power of early and often conversations and learn listening strategies for garnering severity of extreme symptoms: “...Often on the other side once we've made things better, that's when (teens) start to open up about how bad things really were.” - Maggie FLOW is straight talk about extreme periods, with new episodes the second Thursday of each month. Tune in for tips for self study, shared discoveries and to expand menstrual awareness.    Program Notes:   Guest: Dr. Maggie Abraham, The Gyn Space https://thegynspace.com/ IG: @the_gyn_space Email: info@thegynspace.com   How's Your Flow? Calendly link: https://calendly.com/flowtalk/flow-talk-period-pain-stories   HOST: Jessica RIchmond Website: jrich.online IG, @jessicalaurenrichmond  Twitter @geniuspills    HOST: Sarah Watson Website: sarahwatsonlpc.com Podcast: Behind The Bedroom Door Facebook: @sarahwatsonlpcsextherapy IG @swsxtherapy Twitter @swsextherapy   FLOW is sponsored by Takeda, the manufacturer of a treatment for adults with von Willebrand disease. To see if this treatment might be right for you and your needs, visit: https://ssshare.it/2rnK    Connect with BloodStream Media: Find all of our bleeding disorders podcasts on  BloodStreamMedia.com BloodStream on Facebook  BloodStream on Twitter    Check out Believe Limited's Other Work: BloodFeed: bloodfeed.com Bombardier Blood: bombardierblood.com Hemophilia: The Musical: breakingthroughhemophilia.com My Beautiful Stutter: mybeautifulstutter.com/ Stop The Bleeding!: stbhemo.com Teen Impact Awards: teenimpactawards.com The Science Fair: thesciencefair.org  

This episode covers von Willebrand disease.Written notes can be found at https://zerotofinals.com/medicine/haematology/vonwillebranddisease/ or in the haematology section of the 2nd edition of the Zero to Finals medicine book.The audio in the episode was expertly edited by Harry Watchman.

What if understanding your menstrual cycle was the key to unlocking your optimal health?  Join Jessica and Sarah as they dive into the fascinating world of the cervix's adjusting anatomy, the painful environment of menstruating with an extreme bleeding disorder, and the new reality of online access to providers / treatment (no matter where you are located). FLOW is straight talk about extreme periods, with new episodes the second Thursday of each month. Tune in for tips for self study, shared discoveries and to expand menstrual awareness.  Program Notes: How's Your Flow? Calendly link: https://calendly.com/flowtalk/flow-talk-period-pain-stories   HOST: Jessica RIchmond Website: jrich.online IG, @jessicalaurenrichmond  Twitter @geniuspills    HOST: Sarah Watson Website: sarahwatsonlpc.com Podcast: Behind The Bedroom Door Facebook: @sarahwatsonlpcsextherapy IG @swsxtherapy Twitter @swsextherapy   FLOW is sponsored by Takeda, the manufacturer of a treatment for adults with von Willebrand disease. To see if this treatment might be right for you and your needs, visit: https://ssshare.it/2rnK    Connect with BloodStream Media: Find all of our bleeding disorders podcasts on  BloodStreamMedia.com BloodStream on Facebook  BloodStream on Twitter    Check out Believe Limited's Other Work: BloodFeed: bloodfeed.com Bombardier Blood: bombardierblood.com Hemophilia: The Musical: breakingthroughhemophilia.com My Beautiful Stutter: mybeautifulstutter.com/ Stop The Bleeding!: stbhemo.com Teen Impact Awards: teenimpactawards.com The Science Fair: thesciencefair.org

This week in our hematological consultation series, we continue our discussion on von Willebrand disease (vWD), this time focusing on the type 2 subtypes and we also discuss management.In case you missed it, we recommend checking out episode 069 for Part I of this vWD series, covering taking a bleeding history and about Type 1 and Type 3 disease.Content: - What testing do we send for suspected vWD (refresher)- What to do if type 2 vWD is suspected?- What are the different subtypes of Type 2 vWD?- What is "platelet-type vWD"? - What is the approach to perioperative management? ** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodesLove what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast

We resume our hematological consultation series with an overview of von Willebrand disease, the most common inherited bleeding disorder. In this episode, we talk about the initial steps we should take to evaluate suspected von Willebrand disease (vWD) and how to differentiate the various subtypes. We will focus on vWD type 1 and 3! Be sure to tune in next week as we discuss vWD type 2 and management.Content: - Taking a bleeding history - What is von Willebrand factor? - What tests should we order for diagnosis? - What are the different types of vWD?- What is the DDAVP challenge? ** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodesLove what you hear? Tell a friend and leave a review on our podcast streaming platforms!Twitter: @TheFellowOnCallInstagram: @TheFellowOnCallListen in on: Apple Podcast, Spotify, and Google Podcast

Venuz Zamora is an accomplished stage manager with a spirited heart, and her dedication to solutions spills over onto the stage of her life where she manages idiopathic thrombocytopenic purpura (ITP).  Venus's story highlights the power of positive thinking and self-care: “I keep my platelets up with the power of positive thinking.” while also calling to attention the need for collaborative decision-making with medical professionals. FLOW is straight talk about extreme periods, with new episodes the second Thursday of each month. Tune in for tips for self study, shared discoveries and to expand menstrual awareness.    Program Notes:   What is ITP? https://my.clevelandclinic.org/health/articles/5726-immune-thrombocytopenia https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/idiopathic-thrombocytopenic-purpura-itp Books by Manly P Hall: https://www.prs.org/store/c2/Books_by_Manly_P._Hall.html   HOST: Jessica RIchmond Website: jrich.online IG, @jessicalaurenrichmond  Twitter @geniuspills    HOST: Sarah Watson Website: sarahwatsonlpc.com Podcast: Behind The Bedroom Door Facebook: @sarahwatsonlpcsextherapy IG @swsxtherapy Twitter @swsextherapy   FLOW is sponsored by Takeda, the manufacturer of a treatment for adults with von Willebrand disease. To see if this treatment might be right for you and your needs, visit: https://ssshare.it/2rnK    Connect with BloodStream Media: Find all of our bleeding disorders podcasts on  BloodStreamMedia.com BloodStream on Facebook  BloodStream on Twitter    Check out Believe Limited's Other Work: BloodFeed: bloodfeed.com Bombardier Blood: bombardierblood.com Hemophilia: The Musical: breakingthroughhemophilia.com My Beautiful Stutter: mybeautifulstutter.com/ Stop The Bleeding!: stbhemo.com Teen Impact Awards: teenimpactawards.com The Science Fair: thesciencefair.org  

DrBeen#61 Clotting in Severe COVID Patients May Be An Immune Pathology For the first time, this new study shows the possibility of autoreactive immune pathology leading to clotting in severe COVID patients. In Dr. Been's opinion, this mechanism may be behind the clotting found in patients with long COVID and vaccine injury as well. DrBeen: Medical Education Online https://www.drbeen.com/ FLCCC | Front Line COVID-19 Critical Care Alliance https://covid19criticalcare.com/ URL list from Friday, July 7, 2023 Generation of potentially inhibitory autoantibodies to ADAMTS13 in coronavirus disease 2019 - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10307883/ The ADAMTS13‐von Willebrand factor axis in COVID‐19 patients - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753796/ Physiology, Von Willebrand Factor - StatPearls - NCBI Bookshelf https://www.ncbi.nlm.nih.gov/books/NBK559062/ von Willebrand factor - Wikipedia https://en.wikipedia.org/wiki/Von_Willebrand_factor ADAMTS13 - Wikipedia https://en.wikipedia.org/wiki/ADAMTS13 Role of von Willebrand factor in the haemostasis - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159913/ The factor VIII/von Willebrand factor complex: basic and clinical issues - PubMed https://pubmed.ncbi.nlm.nih.gov/12826528/ Platelet α–granules: Basic biology and clinical correlates - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720568/ JCM | Free Full-Text | Age-Associated Increase in Thrombogenicity and Its Correlation with von Willebrand Factor https://www.mdpi.com/2077-0383/10/18/4190 Dynamics and Plasticity of Weibel-Palade Bodies in Endothelial Cells | Arteriosclerosis, Thrombosis, and Vascular Biology https://www.ahajournals.org/doi/10.1161/01.atv.0000209501.56852.6c Disclaimer: This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

I cared enough to make a change & because I could care enough, I could change the way things were & just my little ripple could have an impact. - Rep Jaime Churches Join us on Flow as we delve into the significance of conversations about menstruation, the transformative power of women in leadership roles, and the urgent need former fifth grade teacher Jaime Churches feels to help reluctant learners on the house floor. FLOW is straight talk about extreme periods, with new episodes the second Thursday of each month. Tune in for tips for self study, shared discoveries and to expand menstrual awareness.    Program Notes:   Guest: Representative Jaime Churches https://housedems.com/jaime-churches/ Social Media:    HOST: Jessica RIchmond Website: jrich.online IG, @jessicalaurenrichmond  Twitter @geniuspills    HOST: Sarah Watson Website: sarahwatsonlpc.com Podcast: Behind The Bedroom Door Facebook: @sarahwatsonlpcsextherapy IG @swsxtherapy Twitter @swsextherapy   FLOW is sponsored by Takeda, the manufacturer of a treatment for adults with von Willebrand disease. To see if this treatment might be right for you and your needs, visit: https://ssshare.it/2rnK    Connect with BloodStream Media: Find all of our bleeding disorders podcasts on  BloodStreamMedia.com BloodStream on Facebook  BloodStream on Twitter    Check out Believe Limited's Other Work: BloodFeed: bloodfeed.com Bombardier Blood: bombardierblood.com Hemophilia: The Musical: breakingthroughhemophilia.com My Beautiful Stutter: mybeautifulstutter.com/ Stop The Bleeding!: stbhemo.com Teen Impact Awards: teenimpactawards.com The Science Fair: thesciencefair.org  

Empowering menstruating individuals with knowledge and resources to confidently embrace their bodies is what FLOW is all about. This month, gain insights into how menstrual awareness can enable self-assured decision-making about your body. This month: Assess the latest advances in tackling heavy cycles, to help find relief for those with extreme periods…. Acknowledge the growing demand for diverse birth control methods and non-hormonal alternatives…. Realize the significance of challenging menstruation-related misconceptions and normalizing discussions on this natural bodily function. Plus: identify the avenues for private support and assistance with abortion services. FLOW is straight talk about extreme periods, with new episodes the second Thursday of each month. Tune in for tips for self study, shared discoveries and to expand menstrual awareness.    Program Notes:   Resources Mentioned in this Episode “What a Period is really like” with Cameron Esposito: https://www.youtube.com/watch?v=zeg3h5zbadc Keep Your Abortion Private: https://www.vpnmentor.com/blog/keep-your-abortion-private/   HOST: Jessica RIchmond Website: jrich.online IG, @jessicalaurenrichmond  Twitter @geniuspills    HOST: Sarah Watson Website: sarahwatsonlpc.com Podcast: Behind The Bedroom Door Facebook: @sarahwatsonlpcsextherapy IG @swsxtherapy Twitter @swsextherapy   FLOW is sponsored by Takeda, the manufacturer of a treatment for adults with von Willebrand disease. To see if this treatment might be right for you and your needs, visit: https://ssshare.it/2rnK    Connect with BloodStream Media: Find all of our bleeding disorders podcasts on  BloodStreamMedia.com BloodStream on Facebook  BloodStream on Twitter    Check out Believe Limited's Other Work: BloodFeed: bloodfeed.com Bombardier Blood: bombardierblood.com Hemophilia: The Musical: breakingthroughhemophilia.com My Beautiful Stutter: mybeautifulstutter.com/ Stop The Bleeding!: stbhemo.com Teen Impact Awards: teenimpactawards.com The Science Fair: thesciencefair.org  

Have you heard the myths that normalizing menstruation experiences is a taboo, or that it only happens to women, or that it's only an inconvenience? Don't believe it! Stephanie and Emily are here to bust those myths and share the truth about menstruation experiences. In this episode, you will be able to: Embrace a diverse range of menstruation experiences and tackle extreme situations with confidence. Learn tools to maintain mental well-being and manage symptoms during menstrual cycles. Foster open, empathetic conversations with others about menstruation to promote understanding. Recognize the crucial role of menstrual cycle tracking for overall health and wellness. Enhance teacher-student dialogue about menstruation, encouraging empathy and support in the learning environment. FLOW is straight talk about extreme periods, with new episodes the second Thursday of each month. Tune in for tips for self study, shared discoveries and to expand menstrual awareness.    Program Notes:   Guest Info / Resources Mentioned Cycle Chats https://www.cyclechats.com/  Cycle Chats Instagram https://www.instagram.com/cyclechats/ Cycle Chats Twitter https://twitter.com/cyclechats Cycle Chats Facebook https://www.facebook.com/CycleChats/   The Egg The Egg - A Short Story “RuPaul-blicans” https://time.com/6271330/instagram-turns-republican-anti-lgbtq-drag-queen/   HOST: Jessica RIchmond Website: jrich.online IG, @jessicalaurenrichmond  Twitter @geniuspills    HOST: Sarah Watson Website: sarahwatsonlpc.com Podcast: Behind The Bedroom Door Facebook: @sarahwatsonlpcsextherapy IG @swsxtherapy Twitter @swsextherapy   FLOW is sponsored by Takeda, the manufacturer of a treatment for adults with von Willebrand disease. To see if this treatment might be right for you and your needs, visit: https://ssshare.it/2rnK    Connect with BloodStream Media: Find all of our bleeding disorders podcasts on  BloodStreamMedia.com BloodStream on Facebook  BloodStream on Twitter    Check out Believe Limited's Other Work: BloodFeed: bloodfeed.com Bombardier Blood: bombardierblood.com Hemophilia: The Musical: breakingthroughhemophilia.com My Beautiful Stutter: mybeautifulstutter.com/ Stop The Bleeding!: stbhemo.com Teen Impact Awards: teenimpactawards.com The Science Fair: thesciencefair.org  

Sarah and Jessica discuss the recently proposed ban on period conversation in Florida, the reality of period pain that is as strong as a heart attack, and why education is life saving.   FLOW is straight talk about extreme periods, with new episodes the second Thursday of each month. Tune in for tips for self study, shared discoveries and to expand menstrual awareness.    Program Notes:   Period Talk Resources Foundation for Women & Girls with Bleeding Disorders Let's Talk Period   HOST: Jessica RIchmond Website: jrich.online IG, @jessicalaurenrichmond  Twitter @geniuspills    HOST: Sarah Watson Website: sarahwatsonlpc.com Podcast: Behind The Bedroom Door Facebook: @sarahwatsonlpcsextherapy IG @swsxtherapy Twitter @swsextherapy   FLOW is sponsored by Takeda, the manufacturer of a treatment for adults with von Willebrand disease. To see if this treatment might be right for you and your needs, visit: https://ssshare.it/2rnK    Connect with BloodStream Media: Find all of our bleeding disorders podcasts on BloodStreamMedia.com BloodStream on Facebook  BloodStream on Twitter    Check out Believe Limited's Other Work: BloodFeed: bloodfeed.com Bombardier Blood: bombardierblood.com Hemophilia: The Musical: breakingthroughhemophilia.com My Beautiful Stutter: mybeautifulstutter.com/ Stop The Bleeding!: stbhemo.com Teen Impact Awards: teenimpactawards.com The Science Fair: thesciencefair.org  

Jessica Foley, MD is a pediatric hematologist and oncologist with a passion for camp. Join Sarah and Jessica on FLOW as they deep dive into vWD diagnosis challenges, treatment options, and the joys of hemophilia camp - all in honor of March / Bleeding Disorders Awareness month.   FLOW is straight talk about extreme periods, with new episodes the second Thursday of each month. Tune in for tips for self study, shared discoveries and to expand menstrual awareness.    Program Notes:   vWD Resources NHF - National Hemophilia Foundation WFH - World Federation of Hemophilia  Foundation for Women & Girls with Bleeding Disorders Let's Talk Period   HOST: Jessica RIchmond Website: jrich.online IG, @jessicalaurenrichmond  Twitter @geniuspills    HOST: Sarah Watson Website: sarahwatsonlpc.com Podcast: Behind The Bedroom Door Facebook: @sarahwatsonlpcsextherapy IG @swsxtherapy Twitter @swsextherapy   FLOW is sponsored by Takeda, the manufacturer of a treatment for adults with von Willebrand disease. To see if this treatment might be right for you and your needs, visit: https://ssshare.it/2rnK    Connect with BloodStream Media: Find all of our bleeding disorders podcasts on BloodStreamMedia.com BloodStream on Facebook  BloodStream on Twitter    Check out Believe Limited's Other Work: BloodFeed: bloodfeed.com Bombardier Blood: bombardierblood.com Hemophilia: The Musical: breakingthroughhemophilia.com My Beautiful Stutter: mybeautifulstutter.com/ Stop The Bleeding!: stbhemo.com Teen Impact Awards: teenimpactawards.com The Science Fair: thesciencefair.org

Maryon is driven by injustice. She shares the story of a menopausal woman  “sectioned” (institutionalized) in the UK, her menopause experience dismissed repeatedly… How can awareness transform the lives of those experiencing menopause? …how about the lives of those who love someone experiencing menopause? Happy early Valentine's to all Menopausal menstruators - we love you so much! Join Sarah and Jessica on FLOW as they unpack the essential health benefits of Menopause Awareness with author and educator Maryon Stewart. Maryon is driven by injustice, having witnessed so many menopausal individuals with “no hope“.  FLOW is straight talk about extreme periods, with new episodes the second Thursday of each month. Tune in for tips for self study, shared discoveries and to expand menstrual awareness.    Program Notes:   Maryon Stewart  WEBSITE http://www.maryonstewart.com/book FACEBOOK @ms.maryonstewart TWITTER @maryonstewart IG @maryonstewartmenopause YOUTUBE: https://www.youtube.com/channel/UCNrg33q-OzFaPwV4V86irOg Order Maryon's Book: https://www.amazon.com/dp/1608686825/   HOST: Jessica RIchmond Website: jrich.online IG, @jessicalaurenrichmond  Twitter @geniuspills    HOST: Sarah Watson Website: sarahwatsonlpc.com Podcast: Behind The Bedroom Door Facebook: @sarahwatsonlpcsextherapy IG @swsxtherapy Twitter @swsextherapy   FLOW is sponsored by Takeda, the manufacturer of a treatment for adults with von Willebrand disease. To see if this treatment might be right for you and your needs, visit: https://ssshare.it/2rnK    Connect with BloodStream Media: Find all of our bleeding disorders podcasts on BloodStreamMedia.com BloodStream on Facebook  BloodStream on Twitter    Check out Believe Limited's Other Work: BloodFeed: bloodfeed.com Bombardier Blood: bombardierblood.com Hemophilia: The Musical: breakingthroughhemophilia.com My Beautiful Stutter: mybeautifulstutter.com/ Stop The Bleeding!: stbhemo.com Teen Impact Awards: teenimpactawards.com The Science Fair: thesciencefair.org  

“When we launched we realized how little people with periods knew about their own bodies” - determined to create a positive and welcoming space to focus on reproductive health, founder Robyn McLean started Hello Period Products - helloperiod.com.    Robyn offers FLOW a lesson on vaginal shape (shot glass, champagne flute, or lab dish?), unpacks sustainability challenges, and gives a peek into the New Zealand healthcare scene.   FLOW is straight talk about extreme periods, with new episodes the second Thursday of each month. Tune in for tips for self study, shared discoveries and to expand menstrual awareness.    Program Notes:   LINKS   Hello Period https://helloperiod.com/en-us Hello Period IG, @helloperiodco Hello Period Twitter, @thehellocup Hello Period Facebook, @helloperiodco   HOST: Jessica RIchmond Website: jrich.online IG, @jessicalaurenrichmond  Twitter @geniuspills    HOST: Sarah Watson Website: sarahwatsonlpc.com Podcast: Behind The Bedroom Door Facebook: @sarahwatsonlpcsextherapy IG @swsxtherapy Twitter @swsextherapy   FLOW is sponsored by Takeda, the manufacturer of a treatment for adults with von Willebrand disease. To see if this treatment might be right for you and your needs, visit: https://ssshare.it/2rnK    Connect with BloodStream Media: Find all of our bleeding disorders podcasts on BloodStreamMedia.com BloodStream on Facebook  BloodStream on Twitter    Check out Believe Limited's Other Work: BloodFeed: bloodfeed.com Bombardier Blood: bombardierblood.com Hemophilia: The Musical: breakingthroughhemophilia.com My Beautiful Stutter: mybeautifulstutter.com/ Stop The Bleeding!: stbhemo.com Teen Impact Awards: teenimpactawards.com The Science Fair: thesciencefair.org

This month Jessica and Sarah share clips from Civia Tamarkin's Birthright: A War Story. The Documentary is a call-to-action and offers access points to get informed and get involved in the fight. Focusing on the continued fight ahead, topics include: Trigger Laws, Pro-Roe Abortion Bans, Fetal Heartbeat Abortion Bans, Domestic Gag Rule, Contraception Deserts, and Catholic Healthcare.  FLOW is straight talk about extreme periods, with new episodes the second Thursday of each month. Tune in for tips for self study, shared discoveries and to expand menstrual awareness.    Program Notes: Birthright: A War Story Follow Along with FLOW's Hosts: Key Area Issues Begins Here www.birthrightfilm.com/key-issue-areas/catholic-healthcare   Abortion Resources and Content Abortion Fund Network - https://abortionfunds.org/ Planned Parenthood Abortion Information - https://www.plannedparenthood.org/learn/abortion    Book Reference Ejaculate Responsibly by Gabrielle Stanley Blair   HOST: Jessica RIchmond Website: jrich.online IG, @jessicalaurenrichmond  Twitter @geniuspills    HOST: Sarah Watson Website: sarahwatsonlpc.com Podcast: Behind The Bedroom Door Facebook: @sarahwatsonlpcsextherapy IG @swsxtherapy Twitter @swsextherapy   FLOW is sponsored by Takeda, the manufacturer of a treatment for adults with von Willebrand disease. To see if this treatment might be right for you and your needs, visit: https://ssshare.it/2rnK    Connect with BloodStream Media: Find all of our bleeding disorders podcasts on BloodStreamMedia.com BloodStream on Facebook  BloodStream on Twitter    Check out Believe Limited's Other Work: BloodFeed: bloodfeed.com Bombardier Blood: bombardierblood.com Hemophilia: The Musical: breakingthroughhemophilia.com My Beautiful Stutter: mybeautifulstutter.com/ Stop The Bleeding!: stbhemo.com Teen Impact Awards: teenimpactawards.com The Science Fair: thesciencefair.org

This talk goes over the most common causes of inhirted bleeding disorders. There are two major types of hemophilia – deficiency in factor VIII and IX – which predominant occur in men. Hemophilia A is deficiency of factor VIII and is the most common form of hemophilia treated with factor concentrate. Hemophilia B is less common but treatment principles are the same. There are multiple types of von Willebrand Disease as this is a complex molecular that both carries factor VIII and forms large multimers essential for platelet function. Mild forms of vWD can be treated by desmopressin but von Willebrand factor is needed for more severe types.

This month Jessica and Sarah Flow with Dr. Julia Jaffe, NYC based OB GYN and abortion provider: “There is not a single system of the body unaffected by pregnancy…and there is no other area in our society where we determine if someone should up their life at risk against their will.” FLOW is straight talk about extreme periods, with new episodes the second Thursday of each month. Tune in for tips for self study, shared discoveries and to expand your menstrual awareness. “I really felt proud to do this. These are people who really needed care. I felt nothing but a sense of pride to be able to help people who really did not have a lot of other places to go.” NYC based OBGYN and abortion provider Dr. Julia Jaffe delves into the reality of abortion.   FLOW is straight talk about extreme periods, with new episodes the second Thursday of each month. Tune in for tips for self study, shared discoveries and to expand menstrual awareness.    Program Notes:   Dr. Julia Jaffe, NYC Gramercy Gynecology https://www.gramercygynecology.com/julia-jaffe-gynecologist-new-york.html Dr. Jaffe, IG: https://www.instagram.com/millennialgyn/   Abortion Resources and Content Abortion Fund Network - https://abortionfunds.org/ Planned Parenthood Abortion Information - https://www.plannedparenthood.org/learn/abortion    HOST: Jessica RIchmond Website: jrich.online IG, @jessicalaurenrichmond  Twitter @geniuspills    HOST: Sarah Watson Website: sarahwatsonlpc.com Podcast: Behind The Bedroom Door Facebook: @sarahwatsonlpcsextherapy IG @swsxtherapy Twitter @swsextherapy   FLOW is sponsored by Takeda, the manufacturer of a treatment for adults with von Willebrand disease. To see if this treatment might be right for you and your needs, visit: https://ssshare.it/2rnK    Connect with BloodStream Media: Find all of our bleeding disorders podcasts on BloodStreamMedia.com BloodStream on Facebook  BloodStream on Twitter    Check out Believe Limited's Other Work: BloodFeed: bloodfeed.com Bombardier Blood: bombardierblood.com Hemophilia: The Musical: breakingthroughhemophilia.com My Beautiful Stutter: mybeautifulstutter.com/ Stop The Bleeding!: stbhemo.com Teen Impact Awards: teenimpactawards.com The Science Fair: thesciencefair.org

On the heels of National Coming Out Day, BloodStream is joined by Dr. Nathan Connell, Clinical Chief of Hematology at Brigham and Women's Faulkner Hospital to discuss LGBTQ+ health issues in the bleeding disorder community. Plus, Patrick reconnects with Annelise Ellis, longtime friend and fellow person with a bleeding disorder, as she shares with us her story of how von Willebrand disease impacted her first pregnancy, labor, and delivery.   Show Notes: Subscribe: The BloodStream Podcast   Presenting Sponsor: Takeda, visit bleedingdisorders.com to learn more.   Episode and Segment Sponsors:  Genentech, open enrollment is right around the corner and Genentech has resources to support you through this process. To learn more about these resources, visit www.HemophiliaAccess.com  CSL Behring, visit HemEvolution.com to learn more about gene therapy, or ProtraitsofProgress.com for a virtual photo exhibition chronicling hemophilia's history Connect with BloodStream Media: BloodStreamMedia.com BloodStream on Facebook  BloodStream on Twitter 

Jack Teter is the Regional Director of Government Affairs for Planned Parenthood (PPRM) and has dedicated his efforts to championing that abortion should be free, private and acccessible to all.   On this month's episode of FLOW, Jack shares insights into the legislation creation process and offers actionable advocacy advice (“Always Be Organizing” - “Vote Your Feelings”)! Join hosts Sarah and Jessica to normalize the conversation around reproductive health - and tune in for more of FLOW's Abortion is Healthcare series, throughout 2022.   Tune in for tips for self study, shared discoveries and to expand menstrual awareness. FLOW is straight talk about extreme periods, with new episodes the second Thursday of each month.   Program Notes:   Abortion Resources and Content Abortion Fund Network - https://abortionfunds.org/ Planned Parenthood Abortion Information - https://www.plannedparenthood.org/learn/abortion  HOST: Jessica RIchmond: Website: jrich.online IG, @jessicalaurenrichmond    HOST: Sarah Watson: Website: sarahwatsonlpc.com Podcast: Behind The Bedroom Door Facebook: @sarahwatsonlpcsextherapy IG, @swsxtherapy Twitter @swsextherapy   FLOW is sponsored by Takeda, the manufacturer of a treatment for adults with von Willebrand disease. To see if this treatment might be right for you and your needs, visit: https://ssshare.it/2rnK    Connect with BloodStream Media: Find all of our bleeding disorders podcasts on BloodStreamMedia.com BloodStream on Facebook  BloodStream on Twitter    Check out Believe Limited's Other Work: BloodFeed: bloodfeed.com Bombardier Blood: bombardierblood.com Hemophilia: The Musical: breakingthroughhemophilia.com My Beautiful Stutter: mybeautifulstutter.com/ Stop The Bleeding!: stbhemo.com Teen Impact Awards: teenimpactawards.com The Science Fair: thesciencefair.org

Does your head spin when you look at a von Willebrand panel? In this episode, Dr. Angela Weyand teaches us about the most typical presentations of VWD, how to interpret those pesky antigen and activity levels, and how DDAVP works for bleeds.

FLOW's Sarah and Jessica sit down with Dr. Ashley Brant - Ohio provider, OBGYN and Complex Family Planning Specialist. Dr. Brant joins the conversation to affirm that abortion is life-saving - part of FLOW's straight talk about abortion series. (Review helpful  treminology necessary to hold a conversation about abortion in Part 1: Abortion is Healthcare.) Upcoming episodes focus on: The Reality of Abortion, Abortion Adovacy, Reproductive Justice - and handling stress. Tune in for tips for self study, shared discoveries and to expand menstrual awareness. FLOW is straight talk about extreme periods, with new episodes the second Thursday of each month.   Program Notes:   Abortion Resources and Content Abortion Fund Network - https://abortionfunds.org/ Planned Parenthood Abortion Information - https://www.plannedparenthood.org/learn/abortion  Dr. Brant's recommended folks to follow across the country: Dr. Colleen McNicholas - (St Louis, MO) https://www.plannedparenthood.org/planned-parenthood-st-louis-region-southwest-missouri/who-we-are/press-releases/planned-parenthood-of-the-st-louis-region-and-southwest-missouri-announces-dr-colleen-mcnicholas-as-chief-medical-officer Yashica Robinson - (Huntsville, AL) https://www.aclu.org/bio/yashica-robinson-md Ghazaleh Moayedi - (Texas) https://www.thecmecenter.org/speaker/ghazaleh-moayedi-976923 Katie McHugh - https://www.katiemchughmd.com/about-us - https://www.instagram.com/ktmch/ HOST: Jessica RIchmond: Website: jrich.online IG, @jessicalaurenrichmond    HOST: Sarah Watson: Website: sarahwatsonlpc.com Podcast: Behind The Bedroom Door Facebook: @sarahwatsonlpcsextherapy IG, @swsxtherapy Twitter @swsextherapy   FLOW is sponsored by Takeda, the manufacturer of a treatment for adults with von Willebrand disease. To see if this treatment might be right for you and your needs, visit: https://ssshare.it/2rnK    Connect with BloodStream Media: Find all of our bleeding disorders podcasts on BloodStreamMedia.com BloodStream on Facebook  BloodStream on Twitter    Check out Believe Limited's Other Work: BloodFeed: bloodfeed.com Bombardier Blood: bombardierblood.com Hemophilia: The Musical: breakingthroughhemophilia.com My Beautiful Stutter: mybeautifulstutter.com/ Stop The Bleeding!: stbhemo.com Teen Impact Awards: teenimpactawards.com The Science Fair: thesciencefair.org

Women, girls, and those with the potential to menstruate (WGPPM) who live with hemophilia, have more difficulty getting a diagnosis and accessing adequate care than their biological male counterparts. But why? What research is underway to support the needs of these individuals? This episode takes a wide-lens approach to exploring the socio-cultural barriers and gender-related challenges facing WGPPM in the global hemophilia community.   Contributors: Dawn Rotellini Andra James, MD, MPH Connie Miller, PhD Tyler Buckner, MD Maureen Baldwin, MD, MPH Kristin Paulyson Nunez, M.S., C.G.C   Senior Advisor: Donna DiMichele, MD   Episode Advisors: Angela Weyand, MD Robert Sidonio, MD   Hosted by: Laurence Woollard   Links to learn more: Bercovitz RS. “A new hemophilia carrier nomenclature to define hemophilia in women and girls: Communication from the SSC of the ISTH”: Comment. J  Thromb Haemost 2022;20(7):1744-45. DOI: 10.1111/jth.15727   Chaudhury A, et al. Women and girls with haemophilia and bleeding tendencies: Outcomes related to menstruation, pregnancy, surgery and other bleeding episodes from a retrospective chart review. Haemophilia 2021;27(2):293-304. DOI: 10.1111/hae.14232   d'Oiron R, et al. Women and girls with haemophilia: Lessons learned. Haemophilia 2021;27(S3):75-81. DOI: 10.1111/hae.14094   DiMichele DM, et al. Severe and moderate haemophilia A and B in US females. Haemophilia 2014;20(2):e136-43. DOI: 10.1111/hae.12364   Fox L. Women and girls with hemophilia: Gender-based differences in comprehensive care. NHF Bleeding Disorders Conference 2019. [Online]. Available at: https://www.hemophilia.org/research/research-projects/women-and-girls-with-hemophilia-gender-based-differences-in-comprehensive-care   Kirtava A, et al. Trends in clinical management of women with von Willebrand disease: A survey of 75 women enrolled in haemophilia treatment centres in the United States. Haemophilia 2004;10:158-161. DOI: 10.1046/j.1351-8216.2003.00832.x    Malouin RA, et al. Practice Characteristics of Genetic Counselors Serving the North American Bleeding Disorders Community. [Poster]. World Federation of Hemophilia 2016 World Congress , May 2016.    Miller CH, et al. Women and girls with haemophilia receiving care at specialized haemophilia treatment centres in the United States. Haemophilia 2021;27(6):1037-44. DOI: 10.1111/hae.14403   Rajpurkar M, et al. Current challenges for men and women with mild-to-moderate haemophilia. Haemophilia 2021;27(S1):5-7. DOI: 10.1111/hae.14193   van Galen K, et al. European principles of care for women and girls with inherited bleeding disorders. Haemophilia 2021;27(5):837-47. DOI: 10.1111/hae.14379   van Galen KPM, et al. A new hemophilia carrier nomenclature to define hemophilia in women and girls: Communication from the SSC of the ISTH. J Thromb Haemost 2021;19(8):1883-87. DOI: 10.1111/jth.15397   Weyand AC, James PD. Sexism in the management of bleeding disorders. Res Pract Thromb Haemost 2020;5(1):51-4. DOI: 10.1002/rth2.12468   Show Notes: Presenting Sponsor: Sanofi Subscribe to the Global Hemophilia Report   Connect with the Global Hemophilia Report Global Hemophilia Report on LinkedIn Global Hemophilia Report on Twitter Global Hemophilia Report on Facebook   Connect with BloodStream Media: BloodStreamMedia.com BloodStream on Facebook  BloodStream on Twitter  Listen to the FLOW podcast

Flow's Sarah and Jessica sit down to discuss the fact that abortion is healthcare - and embark on a series of “straight talk about abortion” with part 1: Abortion Is Healthcare.  There are a myriad of medical situations in which pregnancy is a short-term experience. Review helpful terminology to engage in conversation. Upcoming episodes focus on: clinical situations that may call for abortion, necessary and currently missing reproductive health education, and current activism going on to support suffering menstruators.  Tune in for tips for self study, shared discoveries and to be part of the growing menstrual awareness movement! FLOW is straight talk about extreme periods, with new episodes the second Thursday of each month.   Program Notes:   Abortion Content and Resources This American Life - https://www.thisamericanlife.org/774/the-pink-house-at-the-center-of-the-world Shameless Mom Academy - https://shamelessmom.com/episode/amanda-kingsley-speaking-light-into-abortion/ Shout Your Abortion - https://shoutyourabortion.com/ Abortion Fund Network - https://abortionfunds.org/   HOST: Jessica RIchmond: Website: jrich.online IG, @jessicalaurenrichmond    HOST: Sarah Watson: Website: sarahwatsonlpc.com Podcast: Behind The Bedroom Door Facebook: @sarahwatsonlpcsextherapy IG, @swsxtherapy Twitter @swsextherapy   FLOW is sponsored by Takeda, the manufacturer of a treatment for adults with von Willebrand disease. To see if this treatment might be right for you and your needs, visit: https://ssshare.it/2rnK    Connect with BloodStream Media: Find all of our bleeding disorders podcasts on BloodStreamMedia.com BloodStream on Facebook  BloodStream on Twitter    Check out Believe Limited's Other Work: BloodFeed: bloodfeed.com Bombardier Blood: bombardierblood.com Hemophilia: The Musical: breakingthroughhemophilia.com My Beautiful Stutter: mybeautifulstutter.com/ Stop The Bleeding!: stbhemo.com Teen Impact Awards: teenimpactawards.com The Science Fair: thesciencefair.org

Flow's Sarah and Jessica dive into straight talk with Bethany and Marybec, aka Dr. Period Hackers! One part hematologist, one part LGBTQ+ sexuality researcher - Dr. Period Hackers is a powerhouse team sharing menstruation intel on Twitter. With a wide range of knowledge and advocacy routes to share, the FLOW team urges all to follow along @DrPeriodHackers journey.   Tune in for tips for self study, shared discoveries and to be part of the growing menstrual awareness movement! FLOW is  with straight talk about extreme periods; monthly episodes the second Thursday of each month!   Program Notes:   Dr. Period Hackers https://twitter.com/DrPeriodHackers https://twitter.com/bsamuelson_md https://twitter.com/MarybecGriffin   HOST: Jessica RIchmond: Website: jrich.online IG, @jessicalaurenrichmond    HOST: Sarah Watson: Website: sarahwatsonlpc.com Podcast: Behind The Bedroom Door Facebook: @sarahwatsonlpcsextherapy IG, @swsxtherapy Twitter @swsextherapy   FLOW is sponsored by Takeda, the manufacturer of a treatment for adults with von Willebrand disease. To see if this treatment might be right for you and your needs, visit: https://ssshare.it/2rnK    Connect with BloodStream Media: Find all of our bleeding disorders podcasts on BloodStreamMedia.com BloodStream on Facebook  BloodStream on Twitter    Check out Believe Limited's Other Work: BloodFeed: bloodfeed.com Bombardier Blood: bombardierblood.com Hemophilia: The Musical: breakingthroughhemophilia.com My Beautiful Stutter: mybeautifulstutter.com/ Stop The Bleeding!: stbhemo.com Teen Impact Awards: teenimpactawards.com The Science Fair: thesciencefair.org

Emergencies happen in hematology and oncology. This is a fact. But how do we manage these emergencies? Look no further. In this episode, we talk all about our fourth hematologic emergency: thrombotic thrombocytopenic purpura (TTP). Thrombotic thrombocytopenic purpura (TTP):- Be sure to check out episode 009 on thrombocytopenia for a general approach and differential!- New anemia and thrombocytopenia should raise concerns for TTP! Workup: - Peripheral smear - concern for schistocytes. Look at this first! Example of these cells from ASH image bank here- ADAMTS13 level - always draw ASAP before any intervention- Repeat CBC- Reticulocyte count - will have elevated retic count- Citrated platelet count - CMP- PT, PTT, INR- Fibrinogen- Haptoglobin - LDH- Viral serologies Clinical manifestations: - Fever, Anemia, Thrombocytopenia, Renal (AKI), Altered Mental Status- If you see this - the patient is in bad shapeMechanism:- Tiny blood clots form in the body, causing platelet shearing- Loss of ADAMTS13 - This protein normally is responsible for chopping up von Willebrand's factor (vWF)- In the absence of ADAMTS13, vWF multimers are extra long, therefore interacting with platelets/collagen more and causing activation of platelets and clotting system- This causes red blood cell shearing due to small vessel microthrombi (brain, kidneys, heart)- Cytokine release causes fevers Management:- Do not reflexively transfuse platelets; can make situation worse - PLASMIC Score: helps to stratify likelihood of TTP; MDCalc link (https://www.mdcalc.com/plasmic-score-ttp)Treatment: - Plasma exchange: replacing ADATMS13-deficient plasma with ADAMTS13-rich plasma- This is different than plasmapheresis, where we replace plasma with albumin- Steroids: 1mg/kg prednisone daily to stop auto-antibody (against ADAMTS13) production- Confirm with ADAMTS13 levels; if

FLOW's Jessica and Sarah sit down with Mimi Millard of DeLune!   DeLune's Whole Cycle support products use evidence-based research and the team is passionate about furthering clinical research into the period burden and the avoidance/endurance strategy that is common, but not normal!   Tune in for tips for self study, shared discoveries and to be part of the growing menstrual awareness movement! FLOW is  with straight talk about extreme periods; monthly episodes the second Thursday of each month!   Program Notes:   Flow with DeLune  www.Delune.co / use code FLOWPOD20 for 20% off! www.periodcramps.com / take the quiz, help the research study!   HOST: Jessica RIchmond: Website: jrich.online IG, @jessicalaurenrichmond    HOST: Sarah Watson: Website: sarahwatsonlpc.com Podcast: Behind The Bedroom Door Facebook: @sarahwatsonlpcsextherapy IG, @swsxtherapy   FLOW is sponsored by Takeda, the manufacturer of a treatment for adults with von Willebrand disease. To see if this treatment might be right for you and your needs, visit: https://ssshare.it/2rnK    Connect with BloodStream Media: Find all of our bleeding disorders podcasts on BloodStreamMedia.com BloodStream on Facebook  BloodStream on Twitter    Check out Believe Limited's Other Work: BloodFeed: bloodfeed.com Bombardier Blood: bombardierblood.com Hemophilia: The Musical: breakingthroughhemophilia.com My Beautiful Stutter: mybeautifulstutter.com/ Stop The Bleeding!: stbhemo.com Teen Impact Awards: teenimpactawards.com The Science Fair: thesciencefair.org

FLOW's Jessica and Sarah review a variety of extreme period representations in pop culture - namely television and film of the past quarter century. “Vulva, not vagina,” expelling period shame and how to ask for support - what do mensturaters learn from media representations of uterine health? FLOW's hosts ask: How have period representations changed since the horror film CARRIE? Why does Pixar's new movie TURNING RED cause upset in some mommy-circles? And how has premenstrual pain management been normalized in more recent television?  FLOW continues its mission to normalize conversation around menstruation with straight talk about extreme periods; monthly episodes available the second Thursday of each month!   Program Notes: PERIODS IN POP CULTURE TURNING RED: trailer https://www.youtube.com/watch?v=XdKzUbAiswE IT CROWD: “Aunt Irma” https://www.youtube.com/watch?v=VX7mMAyttSE&t=1s BLACKISH: first periods https://www.youtube.com/watch?v=CZynhPpJDv4 NO STRINGS ATTACHED: period playlist https://www.youtube.com/watch?v=pJFZLCoqB9w BIG MOUTH: everybody bleeds https://www.youtube.com/watch?v=NEbQ7CQPfNI   MORE LINKS MENTIONED IN THIS EPISODE Period Pain for Non-Menstruators: https://www.youtube.com/watch?v=Nl9LaisncLk Kotex - Red:https://globalnews.ca/video/6458598/kotex-uses-blood-like-liquid-in-new-ad-instead-of-the-usual-blue Free Bleeding: https://www.cosmopolitan.com/health-fitness/q-and-a/a44392/free-bleeding-marathoner-kiran-gandhi/ Menstruation for Plants (via Delune): https://www.delune.co/blogs/blog/fertilizing-your-plants-with-period-blood-how-to-do-it-and-if-you-should HOST: Jessica RIchmond: Website: jrich.online IG, @jessicalaurenrichmond    HOST: Sarah Watson: Website: sarahwatsonlpc.com Podcast: Behind The Bedroom Door Facebook: @sarahwatsonlpcsextherapy IG, @swsxtherapy   FLOW is sponsored by Takeda, the manufacturer of a treatment for adults with von Willebrand disease. To see if this treatment might be right for you and your needs, visit: https://ssshare.it/2rnK  Connect with BloodStream Media: Find all of our bleeding disorders podcasts on BloodStreamMedia.com BloodStream on Facebook  BloodStream on Twitter    Check out Believe Limited's Other Work: BloodFeed: bloodfeed.com Bombardier Blood: bombardierblood.com Hemophilia: The Musical: breakingthroughhemophilia.com My Beautiful Stutter: mybeautifulstutter.com/ Stop The Bleeding!: stbhemo.com Teen Impact Awards: teenimpactawards.com The Science Fair: thesciencefair.org

FLOW's Jessica and Sarah discuss a myriad of theologies and how they address menstruation… While extreme menstrual experiences can feel punishing, menstruation is not a punishment. Sarah and Jessica share contributions from Morgan Siggard and Dr. Perkins as they unpack the religious-shame associated with periods and the importance of working with different cultural practices in the doctor's office.  FLOW continues its mission to normalize conversation around menstruation - straight talk about extreme periods available on monthly episodes - released the second Thursday of each month! Program Notes: Menstruation and Religion Article: https://link.springer.com/chapter/10.1007/978-981-15-0614-7_11 Purity Culture - Erica Smith Sex Education: https://www.ericasmitheac.com/the-purity-culture-dropout-program CONTRIBUTORS: Morgan Siggard: https://www.instagram.com/morgansiggard Dr. Kerry-Anne Perkins: https://www.instagram.com/callmedoctor.p HOST: Jessica RIchmond: Website: jrich.online IG, @jessicalaurenrichmond  HOST: Sarah Watson: Website: sarahwatsonlpc.com Podcast: Behind The Bedroom Door Facebook: @sarahwatsonlpcsextherapy IG, @swsxtherapy FLOW is sponsored by Takeda, the manufacturer of a treatment for adults with von Willebrand disease. To see if this treatment might be right for you and your needs, visit: https://ssshare.it/2rnK  Connect with BloodStream Media: Find all of our bleeding disorders podcasts on BloodStreamMedia.com BloodStream on Facebook  BloodStream on Twitter  Check out Believe Limited's Other Work: BloodFeed: bloodfeed.com Bombardier Blood: bombardierblood.com Hemophilia: The Musical: breakingthroughhemophilia.com My Beautiful Stutter: mybeautifulstutter.com/ Stop The Bleeding!: stbhemo.com Teen Impact Awards: teenimpactawards.com The Science Fair: thesciencefair.org

Dr. Fred Bertino educates us on anticoagulation regimens for patients after deep venous interventions. --- CHECK OUT OUR SPONSOR RADPAD® Radiation Protection https://www.radpad.com/ --- EARN CME Reflect on how this Podcast applies to your day-to-day and earn AMA PRA Category 1 CMEs: https://earnc.me/NwME1W --- SHOW NOTES In this episode, pediatric interventional radiologist Dr. Fred Bertino joins our host Dr. Chris Beck to discuss new data on anticoagulation regimes before, during, and after venous stenting and/or mechanical thrombectomy. Dr. Bertino starts by reviewing the difference between the compositions of arterial versus venous clots. Arterial clots are formed as a response to endothelial injury and exposure of von Willebrand factor, so these clots are usually platelet-rich. On the other hand, venous clots are formed due to stasis, and these are usually platelet-poor. Therefore, antiplatelet therapy may not be ideal for venous clots. However, Dr. Bertino notes that stent placement can cause endothelial injury at the apposition points of the stent, so the treatment algorithm can become more complex in these cases. The doctors note that there are non-thrombotic diseases that require venous stenting, such as May Thurner syndrome. Dr. Bertino says that addressing this early in the pediatric population can be a safe way to prevent future DVT, as long as children are monitored carefully. Next, Dr. Bertino walks us through his preferred anticoagulation routine for stent placement. Four hours before the procedure, he starts with a dose of Factor Xa inhibitor (apixaban or rivaroxaban) to prevent in-stent thrombosis. The patient is maintained on heparin during the procedure. After the procedure, anticoagulation varies depending on whether a stent was placed, or solely mechanical thrombectomy was performed. Finally, the doctors discuss preferred anticoagulation for special scenarios such as covered stents (which can be more thrombophilic) and patients with malignancies. Dr. Bertino encourages IRs to reach out to their hematology colleagues to stay updated on anticoagulation research, as well as physical and occupational therapists to help patients form long-term DVT prevention plans. --- RESOURCES Find this episode on backtable.com to see the full library of resources mentioned by Dr. Fred Bertino.