Break Nutrition Show

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Raphael Sirtoli is the co-founder of www.breaknutrition.com and hosts the Break Nutrition podcast to take a deep dive into the science behind nutrition and medical studies. He’s joined by recurring co-host Gabor Erdosi - the ‘adipocyte Jedi’ of the Lower Insulin Facebook group - to review papers exp…

BreakNutrition

  • Mar 25, 2020 LATEST EPISODE
  • infrequent NEW EPISODES
  • 1h 7m AVG DURATION
  • 45 EPISODES


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Latest episodes from Break Nutrition Show

Minisode Nutrita Pro - 1

Play Episode Listen Later Mar 25, 2020 12:47


In this minisode, we talk about Nutrita Pro and how you can reach your health goal. => https://nutrita.app

Episode 44 - The Carnivore Diet With Travis Statham

Play Episode Listen Later Apr 6, 2019 69:55


In this episode Travis and I talk about the carnivore diet. Will the diet just come and go? Or is it going to find its place in our mainstream culture in the near future?

Episode 43 - Roundtable chat at LowCarb Denver 2019

Play Episode Listen Later Mar 20, 2019 72:51


Episode 43 is a wide-ranging roundtable discussion taking place at of LowCarb Denver 2019. It includes Shawn Baker of carnivore fame, Dave Feldman and Siobhan Huggins of cholesterolcode.com, Nick Mailer and Nutrita's co-founder Raphael Sirtoli.

Episode 42 - Dr.D’Agostino On Keto, Cancer, Insulin Resistance And...dogs!

Play Episode Listen Later Mar 17, 2019 33:32


In this episode Dominic and I talk about keto diets, cancer metabolism and metabolic therapies, what insulin resistance really is and how keto diets are saving dogs with cancer

Episode 41 - Dr.Ken Ford on AI, ketosis, evolution and better science

Play Episode Listen Later Apr 4, 2018 84:16


Dr.Ford’s bio is impressive. He’s the Founder and Chief Executive Officer of the Florida Institute for Human & Machine Cognition (IHMC), a not-for-profit research institute providing a “new model for interdisciplinary research”. In addition to... a PhD in Computer Science an honorary doctorate from the University of Bordeaux in France he served as the Associate Center Director and Director of NASA’s Center of Excellence in Information Technology he was picked by George Bush and confirmed by the US Senate to serve on the National Science Board (NSB), which is part of the National Science Foundation (NSF) that advises the President and Congress on policy issues he was Chair of the NASA Advisory Council until 2011 and was awarded NASA’s highest honor, their Distinguished Public Service Medal he also supports the Office of the Director of National Intelligence (ODNI) as a member of the Advanced Technology Board (ATB) Check out the episode on breakNutrition: https://breaknutrition.com/episode-41-dr-ken-ford-on-ai-ketosis-evolution-and-better-science/

Episode 40 -Epigenetics with Fabien Delahaye

Play Episode Listen Later Feb 24, 2018 63:50


Short summary: Raphael talks to Fabien Delahaye about epigenetics, what epigenetic mechanisms reveal about fetal growth, and finally how to best interpret scientific studies.

Episode 39 - Weikko Jaross tells us about mitochondria

Play Episode Listen Later Feb 15, 2018 53:41


Short summary: Raphael talks to Weikko Jaross about understanding the mitochondria in our cells as key to our health and how his health tracking app MitoCalc reflects that knowledge.

Episode 38 - Fatty pancreas, fatty liver and diabetes

Play Episode Listen Later Feb 6, 2018 48:47


Raphael and Gabor talk about what it means, healthwise, to have a fatty pancreas; can caloric restriction reverse a fatty pancreas? Is calorie restriction a ‘stunt’ or a sustainable solution?

Episode 37- George Henderson takes us a tour of public health research

Play Episode Listen Later Jan 27, 2018 81:09


Raphael talks to George Henderson about his public health research, drug addiction, food addictions, cholesterol, and heart disease risk on very low-carb diets.

Episode 36 - Metabolic Syndrome series Chapter 2

Play Episode Listen Later Jan 23, 2018 51:29


Raphael and Gabor talk about leptin, how it manage energy use and distribution throughout the body, how much it overlaps with insulin in these tasks and how it plays into the development of Metabolic Syndrome.

Episode 35 - Luis Villasenor the founder of KetoGains

Play Episode Listen Later Jan 19, 2018 84:51


Episode 35 - Luis Villasenor the founder of KetoGains by BreakNutrition

Episode 34 - Metabolic Syndrome series Chapter 1

Play Episode Listen Later Jan 9, 2018 62:03


Raphael and Gabor introduce Metabolic Syndrome; what is it? who pioneered it? why insulin resistance lies at its heart? A 2017 study comparing measures and estimations insulin resistance is reviewed.

Episode 33 - Nick Mailer tightens nutrition’s loose philosophy screws

Play Episode Listen Later Jan 3, 2018 102:16


Raphael talks to Nick Mailer who explains how philosophy can be a god-send to the barely-a-science field of nutrition, notorious for lax standards and logical fallacies.

Episode 32 - Dr.Feinman gives the Low-Carb 2017 State of the Union

Play Episode Listen Later Dec 28, 2017 87:23


Short summary: Raphael talks to Prof Feinman about the state of low-carb in 2017 and what can be done to improve nutrition research.

Episode 31 - Richard Morris joins Gabor & Raphael for a nutrition nerd safari

Play Episode Listen Later Dec 25, 2017 113:35


In episode 31 Raphael, Gabor and Richard go on a nutrition nerd safari

Episode 30 - Amy Berger on the Protein question

Play Episode Listen Later Dec 18, 2017 64:54


In episode 30 I talk to Amy about the best and the worst advice given by the low-carb community regarding protein recommendations

Episode 29 - Steven Hamley zooms in & out on dietary patterns affecting our health

Play Episode Listen Later Dec 11, 2017 61:42


In episode 29 I I talk to Steven about the AHA’s dietary recommendations, insulin resistance and factors in the liver mediating the latter.

Episode 28 - Amber O’Hearn says meat heals & birds fly

Play Episode Listen Later Nov 24, 2017 58:57


In episode 28 I I talk with Amber about carnivory, protein needs and what birds can teach us about our context dependent dietary needs.

Episode 27 - Adipocytes and insulin resistance

Play Episode Listen Later Nov 5, 2017 68:47


In episode 27 Gabor and I talk about how the morphology of fat cells may soon be used to predict people’s location the spectrum of metabolic dysfunction.

Episode 26 – Dr.Bikman: well behaved fat and good insulin signaling FTW

Play Episode Listen Later Oct 29, 2017 56:23


In episode 26 Dr.Bikman and I talk about the how insulin signaling and the different kinds of adipose play into metabolic disease

Episode 25 - Larry & Kay Lynne Diamond: education is power

Play Episode Listen Later Oct 3, 2017 93:27


Short summary: In episode 25 I discuss the empowering effect of educating oneself on the science of health and nutrition with Larry and Kay Lynne Diamond.

Episode 24 - Tucker and Gabor on Seed Oils vs Refined Carbs - Part 2

Play Episode Listen Later Sep 18, 2017 90:21


In episode 24 Gabor and I talk to Tucker Goodrich about the negative effects of omega-6 seed oils on our health and how they compared to refined flours.

Episode 23 - Tucker Goodrich dishes on seed oils

Play Episode Listen Later Sep 3, 2017 74:52


In episode 23 I talk to Tucker Goodrich about the negative effects of omega-6 seed oils on our health.

Episode 22 - Dietary (in)sanity with Dr.Ede

Play Episode Listen Later Aug 28, 2017 74:59


In episode 22 I talk to psychiatrist and nutritionist Dr.Georgia Ede about how our diet affects mental health.

Episode 21 - Measuring Acetyl-CoA in a live rat, for the sake of metabolism

Play Episode Listen Later Aug 17, 2017 44:17


Short summary: In episode 21 Gabor and I explore how measuring hepatic acetyl-CoA in live rats advances our understanding of metabolism.

Episode 20 - Sweet, sweet insulin and you

Play Episode Listen Later Aug 7, 2017 67:56


In episode 20 Gabor and I explore the ways in which fructose potentiates the release of insulin and the molecular basis for your ‘sweet tooth’.

Episode 19 - Marty Kendall on nutrient dense diets

Play Episode Listen Later Jul 6, 2017 65:25


In episode 19 Marty Kendall and I talk about nutrient dense diets and explore why some recommendations are more or less trustworthy

Episode 18 - Peter Ballerstedt PhD: better nutrition through sustainable agriculture

Play Episode Listen Later Jun 27, 2017 70:20


In episode 18 Peter Ballerstedt and I talk about how sustainable agricultural practices can help people feed themselves better

Episode 17 - Dr.Shawn Baker lifts like a crane and eats like a lion

Play Episode Listen Later Jun 16, 2017 68:35


In episode 17 I talk to Dr.Shawn Baker about carnivorous diets and athletic performance, the diets myths surrounding them, and micronutrient needs on all-meat diets

Episode 16 - The curious case of Dr. Ted Naiman

Play Episode Listen Later Jun 8, 2017 55:44


In episode 16 I talk to Ted Naiman

Episode 15 - how do mTORC2 and ChREBP-β keep the fat cycle going?

Play Episode Listen Later May 24, 2017 73:53


In episode 15 Gabor and I review two studies looking at liver health by linking the process of de novo lipogenesis, with the activity of mTORC2, ChREBP-β and SREBP1c.

Episode 14 - Freezing your fat off

Play Episode Listen Later May 14, 2017 66:41


In episode 14 Gabor and I review a study from 2015 paper looking at the knock-on effects of adapting to cold temperatures in terms of insulin sensitivity and the behavior of fat tissue.

Episode 13 - What happens to fructose-fed monkeys?

Play Episode Listen Later May 1, 2017 80:09


Short summary: In episode 13 Gabor and I review a 2011 study looking at the metabolic consequences of rhesus monkeys being fed a grain-based diet supplemented with 500mL of fructose loaded Kool-Aid a day over a year.

Episode 12 - Decoding Cholesterol with Dave Feldman

Play Episode Listen Later Apr 21, 2017 61:36


Short summary: I talk to engineer Dave Feldman about what his dietary self-experiments taught him cholesterol in human physiology. His “N = 1” experimentation is not only very interesting and rigorous but most importantly, it cannot be explained by current mainstream notions in lipidology. We also discuss the implications that this may have for cardiovascular disease.

Episode 11 - Obesity: a bird’s eye view

Play Episode Listen Later Apr 20, 2017 65:17


Short summary: In episode 11 Gabor selects 2 papers on the physiology of migrating birds that fatten up for their voyage and we discuss what this can tell us about human obesity. The first paper is from 2002 by Bairlein and is called “How to get fat: nutritional mechanisms of seasonal fat accumulation in migratory songbirds” http://www.ncbi.nlm.nih.gov/pubmed/12008967. The second is called “Adipose energy stores, physical work, and the metabolic syndrome: lessons from hummingbirds” http://www.ncbi.nlm.nih.gov/pubmed/16351726 and is by Hargrove et al. from 2005.

Episode 10 - Medical uses of ketogenic and low carb diets with Ellen Davis

Play Episode Listen Later Apr 17, 2017 61:33


Short summary: With guest Ellen Davis we discuss the many medical applications of ketogenic and low carb diets, all of which is explored in depth in her 3 books “Fighting Cancer with a Ketogenic Diet”, “The Ketogenic Diet for Type 1 Diabetes” and “Conquering Type 2 Diabetes with a Ketogenic Diet”.

Episode 9 – Amy Berger’s new book “The Alzheimer’s Antidote”, gluconeogenesis and exogenous ketones

Play Episode Listen Later Apr 9, 2017 80:45


In her new book “The Alzheimer’s Antidote”, Amy Berger explains how improving one’s metabolism through a well-formulated low-carb high-fat diet is a worthwhile strategy to manage the disease. We then discuss how ‘excess protein’ is an overblown concern when it comes keeping adequately low blood sugar by not excessively stimulating gluconeogenesis. Lastly, we discuss the right and wrong reasons to sell and use exogenous ketones.

Episode 8 - Starch digestibility and limitations of the glycemic response

Play Episode Listen Later Apr 6, 2017 51:24


In episode 8 of the Break Nutrition show we discuss 2 papers which explore the glycemic, insulin and incretin responses and how the digestibility of starch as well as the apportioning of endogenous vs exogenous glucose comes into play. The paper from 2012 is “Slowly and rapidly digestible starchy foods can elicit a similar glycemic response because of differential tissue glucose uptake in healthy men” http://www.ncbi.nlm.nih.gov/pubmed/22990033. The paper from 2015 is “Plasma glucose kinetics and response of insulin and GIP following a cereal breakfast in female subjects: effect of starch digestibility” http://www.ncbi.nlm.nih.gov/pubmed/25852025.

Episode 7 - How processed starches affect metabolic responses

Play Episode Listen Later Mar 21, 2017 73:32


In Episode 7 of the Break Nutrition show we discuss how changes in the cellular structure of starchy tubers and grains arising from certain types of food processing can disrupt our glycemic and insulin responses.

Episode 6 - why bariatric surgery improves metabolic parameters quickly

Play Episode Listen Later Mar 8, 2017 56:32


In Episode 6 of the Break Nutrition Show we discuss why bariatric surgery improves metabolic parameters quickly

Episode 5 - how enlarged adipocytes overloaded with lipids lead to insulin resistance

Play Episode Listen Later Feb 24, 2017 77:30


The Break Nutrition Show provides a unique format to explore diet and health topics by alternating between in-depth technical discussions of specific research papers and shorter lay-friendly episodes on general health and nutrition questions

Episode 4 - The rate at which sugar is absorbed by the gastro intestinal system affects obesity

Play Episode Listen Later Feb 21, 2017 77:30


In Episode 4 of the Break Nutrition Show we discuss why the rate at which you absorb sugar may affect obesity, diabetes and general metabolic health

Episode 3 - Affecting fat loss in rodents by caloric restriction, knocking out insulin genes

Play Episode Listen Later Feb 18, 2017 78:31


In Episode 3 of the Break Nutrition show we discussed rodent studies showing an insulin gene dosage-dependent effect on adiposity, the interplay between caloric restriction & circulating insulin, as well as how incretin hormones affect fat loss dynamics"

Episode 2 - Trafficking fatty acids properly to avoid ectopic fat deposition

Play Episode Listen Later Feb 8, 2017 53:02


In Episode 2 of the BreakNutrition Show we talked about how dysregulated cycling of fat between fat cells, the liver and the fat we eat can lead to obesity

Episode 1 - Linking dysregulated adipocyte fat flow to diabetes

Play Episode Listen Later Feb 8, 2017 61:40


In Episode 1 of the BreakNutrition Show we talked about how how dysregulated fat flow from fat cells can drive the creation of new glucose in the liver and lead to diabetes

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