The Metabolomist podcast

In this episode, Alice Limonciel and Cristina Legido-Quigley discuss the relevance of lipidomics in obesity and neurology, monitoring dietary intervention with lipidomics, and the contribution of exploring sex differences to precision medicine.

In this episode, Alice Limonciel and Audrey Le Gouellec discuss how metabolomics provided a new understanding of cystic fibrosis, what metabolomics will bring to the medicine of tomorrow, and what we, as a community, need to do to get there.

In this episode, Alice Limonciel and Sandi Azab discuss where metabolomics can provide maximum impact in epidemiology. They explore the surprising metabolic sex differences in childhood obesity that already exist in children under the age of five, discuss how to apply the fundamentals of epidemiology when designing metabolomics studies, and touch upon the importance of investigating ethnic diversity in precision medicine.

In this episode, Alice Limonciel and Marc-Emmanuel Dumas discuss metabolites as the messengers of the microbiome towards the host, the added value of investigating multiple measures of the phenotype in the context of liver disease, and how machine learning and AI will impact the field in the near future.

In this episode, Alice Limonciel and Vadim Gladyshev discuss the use of omics in aging research, the place of metabolomics in a field largely dominated by DNA methylation, how aging research can impact all of biomedical research, and the reversibility of aging markers in various models.

In this episode, Alice Limonciel and Sabine Bahn discuss how to improve the tools for diagnosing and treating patients with mental illness, from depression to schizophrenia and bipolar disorder. Together, they discuss the relevance of omics to provide much needed physical diagnosis of these conditions, and the impact of metabolomics in this field.

In this episode, Alice Limonciel and Robert Nagourney discuss the benefits of looking into phenotype rather than genotype when studying cancer, how metabolomics contributes to the patient's journey through personalized medicine, and the ways that survival prediction can be interpreted.

In this episode, Alice Limonciel and Haley Chatelaine discuss the benefits of using metabolomics to study multiple diseases, the fascinating world of fat-soluble vitamins and their absorption in patients with metabolic syndrome. This episode was created in collaboration with the Early Career Members (ECM) of the Metabolomics Association of North America (MANA) and begins with a conversation about life as an early career scientist with Arpana Vaniya and Nicole Prince, who are restively chair and vice-chair of MANA-ECM.

In this episode, Alice Limonciel and Sapna Sharma discuss how to make the most of the omic data already generated in cohort studies, the place of metabolomics in multi-omics strategies, and how to go beyond associations and towards causal relationships and their implications for medicine.

In this episode, Alice Limonciel and Karel Kalecký discuss what to look out for when planning a metabolomics experiment with brain tissue samples from biobanks, what characterizes Parkinson's and Alzheimer's disease at the metabolic level, and his experience navigating biological interpretation as a computer scientist turned metabolomist.

In this episode, Alice Limonciel and Gary Patti discuss the applications of flux metabolomics to the study of cancer, the benefits of various biological models, and the potential of nutritional intervention to study and influence cancer metabolism.

In this episode, Alice Limonciel and Rachel Kelly discuss the relevance of metabolomics to the field of epidemiology, the challenges in combining metabolomic studies for large meta-analyses, and the application of metabolomics to create metabotypes of asthma.

In this episode, Alice Limonciel and Jennifer Kirwan talk about what stands in the way of new applications of metabolomics in the clinics, the importance of quality assurance and quality control (QA/QC), and how this can affect your experiments all the way to the interpretation of the biology.

In this episode, Alice and David Wishart talk about the many ways that clinical practice and clinical research will benefit from a broader application of metabolomics, how databases support the metabolomics field, and why we need to keep developing better tools to support data analysis and interpretation.

In this episode, Alice and Robert Ahrends talk about the importance of standardization and quantification in lipidomics, how to analyze and interpret lipidomic datasets, and how lipids are much more that structural or energy storage molecules.

In this episode, Alice talks to Prof. emer. Hannelore Daniel about the joint evolution of nutrition research and omics, common misconceptions about the microbiome, and the influence of diet and exercise on the metabolome.

In this episode, Alice talks to Prof. Karsten Suhre about the added value of combining genomics with metabolomics, tips and tricks to find confounders, and the power of computing metabolite ratios.

This episode features exclusive interviews collected at the 2022 Metabolomics Society conference in Valencia, Spain.

In this episode, Alice talks to Dr. Julie Courraud about the importance of project planning, the use of metabolomics in the clinics, and the pitfalls to avoid when you begin in the field.

In this introductory episode Alice talks about what drove her to create The Metabolomist and what you can expect in the first set of episodes featuring her as your host.

In this episode, Alice talks to Jan Krumsiek about the intrinsic differences between the female and male metabolomes, developing open-access bioinformatic tools, and how data-driven analyses can bring us closer to the biology.

In this episode, Alice talks to Gabi Kastenmüller about how knowledge is power for data stratification, the importance of teamwork in a metabolomics project, and her team's effort to maintain data and bioinformatic tools available for the community.