Podcasts about Mass spectrometry

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Best podcasts about Mass spectrometry

Latest podcast episodes about Mass spectrometry

An Unexpected Fight: A pediatric cancer podcast

Claire L. Carter, Ph.D., is an Assistant Member of the Center for Discovery and Innovation; Assistant Professor of Pathology at Hackensack Meridian School of Medicine; and Co-Director of the Mass Spectrometry and Analytical Pharmacology Shared Resource at the NCI-designated Georgetown Lombardi Comprehensive Cancer Center.Dr. Carter completed her Ph.D. in Chemistry at the University of Birmingham, UK, under the supervision of Professor Josephine Bunch. She then moved to the US for a postdoctoral appointment at the University of Maryland Baltimore, where she worked on normal tissue radiation injury. At the Hackensack Meridian Center for Discovery and Innovation, Dr. Carter has built a translational pediatric neuro-oncology research program in partnership with Dr. Derek Hanson, Director of Pediatric Neuro-oncology, Joseph M. Sanzari Children's Hospital, Hackensack University Medical Center.Dr. Carter possesses a rare translational background that combines expertise in bioanalytical chemistry, clinical histopathology and biomedical science. Her group are using next generation imaging techniques to develop a deep understanding of the biological and transitional states of tumor cells as shaped by their spatiotemporal location within patient tumors and preclinical models. Their focus is on targeting lipid signaling and metabolism for less toxic and more efficacious treatments in highly aggressive pediatric brain tumors. In addition to using mass spectrometry imaging for intratumoral pharmacokinetic/pharmacodynamic (PK/PD) studies to identify more efficacious treatment regimens that can be rapidly translated into clinic gain.You can also get involved with the Gold Ribbon Kids Cancer Foundation or the National Pediatric Cancer Foundation through fundraising, volunteering, promoting awareness, or contributing to pediatric cancer research. Visit goldribbon-kids.org or nationalpcf.org for more informationTo contact Tiffany, please email info@goldribbon-kids.orgTo contact Kelly, please email kgoddard@nationalpcf.orgSupport the show

Clinical Chemistry Podcast
Clonality Determination by Detecting Unmodified Monoclonal Serum Free Light Chains Using On-Probe Extraction Coupled with Liquid Chromatography-High-Resolution Mass Spectrometry

Clinical Chemistry Podcast

Play Episode Listen Later Jan 2, 2025 9:55


Analytically Speaking
Ep. 32: Don't skip seminar…you might miss a life-changing event

Analytically Speaking

Play Episode Listen Later Jan 2, 2025 49:10


In this episode, podcast co-hosts Dr. Dwight Stoll and Dr. James Grinias talk with Dr. Benjamin Garcia. Dr. Garcia is the Raymond H. Wittcoff Distinguished Professor and Head of the Department of Biochemistry and Molecular Biophysics in the School of Medicine at Washington University in St. Louis. His research interests primarily focus on the development of mass spectrometry-based proteomic approaches for the analysis of post-translational modifications of proteins (PTMs) and modified proteomes. His group specializes in high-throughput and quantitative analysis of many classes of modified proteins, especially epigenetic histone PTMs. He is a prolific author and scientific leader, with an h-index approaching 120. He has received a LOT of awards to date, but we sat down with him at the Eastern Analytical Symposium where he was recognized for his recent EAS Award for Outstanding Achievement in Mass Spectrometry. In the conversation we talk about the origins of Dr. Garcia's interests in analytical science, mass spectrometry, and biomedical research, and he shares his thoughts about the current state and near future for technologies used for biomolecule separations including peptides, proteins, and oligonucleotides. We also discuss Dr. Garcia's highly impactful efforts to promote participation in the analytical sciences by people from all backgrounds, and he shares some thoughts about the “to-do list” for his upcoming term as chair of the ACS Division of Analytical Chemistry.

Contaminated Site Clean-Up Information (CLU-IN): Internet Seminar Video Archives
Advancing Environmental Health Research with Artificial Intelligence and Machine Learning: Session III — ML & AI Applications to Understand Omics, Metabolomics, & Immunotoxicity and Optimizing Bioengineering Using Datasets, Models, &

Contaminated Site Clean-Up Information (CLU-IN): Internet Seminar Video Archives

Play Episode Listen Later Nov 22, 2024


The NIEHS Superfund Research Program (SRP) is hosting a Risk e-Learning webinar series focused on using artificial intelligence (AI) and machine learning to advance environmental health research. The series will feature SRP-funded researchers, collaborators, and other subject-matter experts who aim to better understand and address environmental health issues by applying AI and machine learning approaches to complex issues. Recent advances in AI and machine learning methods show promise to improve the accuracy and efficiency of environmental health research. Over the course of three sessions, presenters will discuss how they use AI and machine learning approaches to improve chemical analysis, characterize chemical risk, understand microbial ecosystems, develop technologies for contaminant removal, and more. In the third and final session, ML & AI Applications to Understand Omics, Metabolomics, & Immunotoxicity and Optimize Bioengineering Using Datasets, Models, and Mass Spectrometry, speakers will discuss how they apply machine learning and artificial intelligence tools to analyze mass spectrometry and microscopy data and optimize models for understanding metabolomics, metabolite pathways, and immunotoxicology To learn about and register for the other sessions in this webinar series, please see the SRP website. Grace Peng, Ph.D., is a co-coordinator of the National Institutes of Health (NIH) Common Fund's Bridge to Artificial Intelligence (Bridge2AI) program, bridging the gap between the biomedical, behavioral and bioethics research communities and the data science/AI communities through a consortium of diverse experts to set the stage for widespread adoption of AI/ML in medicine. Dr. Peng will give an overview of the Bridge2AI program and introduce one of their projects at the University of California San Diego — Trey Ideker, Ph.D. Dr. Ideker will discuss the cell maps for AI (CM4AI) functional genomics project, one of four major data generation projects under the Bridge2AI program. The goal of the project is to provide a comprehensive map of human cellular components through generation of major spatial proteomics datasets. John Efromson, M.S., will present on Ramona Optic, Inc.'s Multi-Camera Array Microscope [MCAM(TM)], which is used to automate imaging and computer vision analysis of zebrafish and greatly improves previous throughput and analysis capabilities. Multiple applications of machine learning will be discussed, including behavioral pose estimation and phenotyping, morphological analysis, and cell counting and fluorescence quantification, as well as how these distinct analyses can be used together for pharmacology, toxicology, and neuroscience research. Speakers:Grace C.Y. Peng, Ph.D., Division of Discovery Science and Technology (Bioengineering), National Institute of Biomedical Imaging and Bioengineering and Trey Ideker, Ph.D., University of California San DiegoJohn Efromson, M.S., Ramona OpticsForest White, Ph.D., Massachusetts Institute of Technology (MIT)Moderator: Hunter Moseley, Ph.D., University of Kentucky To view this archive online or download the slides associated with this seminar, please visit http://www.clu-in.org/conf/tio/SRP-ML-AI3_112224/

Contaminated Site Clean-Up Information (CLU-IN): Internet Seminar Audio Archives
Audio for "Advancing Environmental Health Research with Artificial Intelligence and Machine Learning: Session III — ML & AI Applications to Understand Omics, Metabolomics, & Immunotoxicity and Optimizing Bioengineering Using Datasets, M

Contaminated Site Clean-Up Information (CLU-IN): Internet Seminar Audio Archives

Play Episode Listen Later Nov 22, 2024


The NIEHS Superfund Research Program (SRP) is hosting a Risk e-Learning webinar series focused on using artificial intelligence (AI) and machine learning to advance environmental health research. The series will feature SRP-funded researchers, collaborators, and other subject-matter experts who aim to better understand and address environmental health issues by applying AI and machine learning approaches to complex issues. Recent advances in AI and machine learning methods show promise to improve the accuracy and efficiency of environmental health research. Over the course of three sessions, presenters will discuss how they use AI and machine learning approaches to improve chemical analysis, characterize chemical risk, understand microbial ecosystems, develop technologies for contaminant removal, and more. In the third and final session, ML & AI Applications to Understand Omics, Metabolomics, & Immunotoxicity and Optimize Bioengineering Using Datasets, Models, and Mass Spectrometry, speakers will discuss how they apply machine learning and artificial intelligence tools to analyze mass spectrometry and microscopy data and optimize models for understanding metabolomics, metabolite pathways, and immunotoxicology To learn about and register for the other sessions in this webinar series, please see the SRP website. Grace Peng, Ph.D., is a co-coordinator of the National Institutes of Health (NIH) Common Fund's Bridge to Artificial Intelligence (Bridge2AI) program, bridging the gap between the biomedical, behavioral and bioethics research communities and the data science/AI communities through a consortium of diverse experts to set the stage for widespread adoption of AI/ML in medicine. Dr. Peng will give an overview of the Bridge2AI program and introduce one of their projects at the University of California San Diego — Trey Ideker, Ph.D. Dr. Ideker will discuss the cell maps for AI (CM4AI) functional genomics project, one of four major data generation projects under the Bridge2AI program. The goal of the project is to provide a comprehensive map of human cellular components through generation of major spatial proteomics datasets. John Efromson, M.S., will present on Ramona Optic, Inc.'s Multi-Camera Array Microscope [MCAM(TM)], which is used to automate imaging and computer vision analysis of zebrafish and greatly improves previous throughput and analysis capabilities. Multiple applications of machine learning will be discussed, including behavioral pose estimation and phenotyping, morphological analysis, and cell counting and fluorescence quantification, as well as how these distinct analyses can be used together for pharmacology, toxicology, and neuroscience research. Speakers:Grace C.Y. Peng, Ph.D., Division of Discovery Science and Technology (Bioengineering), National Institute of Biomedical Imaging and Bioengineering and Trey Ideker, Ph.D., University of California San DiegoJohn Efromson, M.S., Ramona OpticsForest White, Ph.D., Massachusetts Institute of Technology (MIT)Moderator: Hunter Moseley, Ph.D., University of Kentucky To view this archive online or download the slides associated with this seminar, please visit http://www.clu-in.org/conf/tio/SRP-ML-AI3_112224/

Bringing Chemistry to Life
The metrology aspects of PFAS

Bringing Chemistry to Life

Play Episode Listen Later Aug 21, 2024 33:55


Early in her career, Dr. Jessica Reiner realized that she cared more about ensuring the accuracy of the measurements she was making than making the measurements themselves. This realization, combined with experience in working with PFAS, led to her current role as Research Chemist at the National Institute of Standards and Technology (NIST).Join us to hear an insider's perspective on the PFAS topic, with a deep dive into the analytical methods used to detect, quantify, and identify PFAS species. Jessica and her team use LC-MS, anion exchange chromatography, and other orthogonal methods in their work and they focus on creating, validating, and maintaining reference materials (RM) and standard reference materials (SRM) that are used to help ensure that PFAS measurements are accurate and comparable with those made in other laboratories around the world. From challenges around defining a PFAS, to creating a stable, ultra-low concentration standard, to detecting ultra-high concentrations PFAS, Jessica provides an ace analytical chemist's perspective grounded in the metrology of it all.As always, and in addition to the great science, you'll get to learn about Jessica's personal career path, the ups and downs of her work, and hear her advice for career development. Related episodes: Season 4, Ep.2: The father of green chemistrySeason 2, Ep.7: Fresh urban waterSeason 1, Ep.3: There's chemistry in the air!Bonus content!Access bonus content curated by this episode's guest by visiting www.thermofisher.com/chemistry-podcast for links to recent publications, podcasts, books, videos and more.View the video of this episode on www.thermofisher.com/chemistry-podcast.A free thank you gift for our listeners! Request your free Bringing Chemistry to Life t-shirt on our episode website.Use code 0chemRcks in August, and BCTLisn3R in September. We read every email so please share your questions and feedback with us! Email helloBCTL@thermofisher.com

Everything Kratom
S14 E23 - Analyzing Kratom using GC-MS... what does that mean, though?

Everything Kratom

Play Episode Listen Later Jun 12, 2024 12:18


Today, I talk about what I found when looking into the process of analyzing kratom through Gas Chromatography and Mass Spectrometry, or GC-MS, methods that I have often seen cited as ways to understand the makeup of kratom. ❗️DISCLAIMER: The information and topics discussed in this show is not intended as medical advice or endorsement of Kratom use. Kratom has not been approved by the FDA. The opinions expressed herein are solely those of the host or the guest(s) and should not be construed as personal or medical recommendations. Always consult a healthcare professional before making any decisions about substance use, and ensure compliance with local laws. The producers and host of this show assume no liability for any actions taken in reliance on the content provided. ❗️ *** HAPPY HIPPO Discount ***: Coupon code EVERYTHINGKRATOM at checkout, or click on this link - ⁠⁠https://happyhippoherbals.com/r?id=ul2k1j⁠⁠ & ETHA Natural Botanicals Discount - Coupon code EVERYTHINGKRATOM at checkout, or click on this link - ⁠https://ethalivefully.com/discount/EVERYTHINGKRATOM?aff=243⁠⁠ Please support this podcast with a small monthly donation here! ⁠⁠https://anchor.fm/everything-kratom/support ⁠⁠ Thank you all so much for listening! Available wherever you get your podcasts: YouTube Channel: ⁠⁠https://www.youtube.com/channel/UCUsCC1nBchi_xMX9wRyQ_nA⁠⁠ Spotify -⁠⁠ https://open.spotify.com/show/2fO3Xsx1BbNUs2rpXiQs3s⁠⁠ Google Podcasts - ⁠⁠https://www.google.com/podcasts?feed=aHR0cHM6Ly9hbmNob3IuZm0vcy82OWUxMzZjNC9wb2RjYXN0L3Jzcw==⁠⁠ Apple Podcasts - ⁠⁠https://podcasts.apple.com/us/podcast/everything-kratom/id1584592399⁠⁠ Pocket Casts -⁠⁠ https://pca.st/mql8q14u⁠⁠ RadioPublic - ⁠⁠https://radiopublic.com/everything-kratom-WzkkBK⁠⁠ Overcast - ⁠⁠https://overcast.fm/itunes1584592399/everything-kratom⁠⁠ Reason - ⁠⁠https://reason.fm/podcast/everything-kratom?user=16e32b81-d623-4dcd-a000-623566fdc41a⁠⁠ Website: ⁠⁠https://everythingkratom279311648.wordpress.com⁠⁠ --- Send in a voice message: https://podcasters.spotify.com/pod/show/everything-kratom/message Support this podcast: https://podcasters.spotify.com/pod/show/everything-kratom/support

RTÉ - Drivetime
Fascinating research on the Scent of Parkinsons and how it can improve services for patients

RTÉ - Drivetime

Play Episode Listen Later May 13, 2024 6:01


Novel research into Parkinson's Disease and how it can be diagnosed by scent will be presented on Wednesday evening in Maynooth University. Professor Perdita Barran who is is Chair of Mass Spectrometry in the Department of Chemistry at The University of Manchester, will explain the fascinating story of her research.

Brain Biohacking with Kayla Barnes
NAD+ Optimization with Dr. Jin-Xiong She

Brain Biohacking with Kayla Barnes

Play Episode Listen Later Apr 26, 2024 58:20


Today I am speaking with Dr. Jin-Xiong She about all thing NAD+, we discuss what it is, how to measure your NAD+ levels, what impact your NAD+ levels have on your health and longevity, how to optimize your NAD+ levels and so much more! Use code KAYLA to save on all NAD+ optimization products ! About Dr. Dr. Jin-Xiong She Dr. Jin-Xiong She received his college education in China and PhD degree in France.  After a short postdoctoral training at the University of Florida (UF), he was quickly promoted to Assistant Professor, Associate Professor, Full and Endowed Professor.  He served as Division Chief of Experimental Pathology and Director of Research of the UF's world-class Diabetes Center.  Dr. She was recruited in 2002 to be the Georgia Research Alliance Eminent Scholar in Genomic Medicine at the Medical College of Georgia.  He was the founding Director of the Center for Biotechnology and Genomic Medicine, Professor of the Departments of Obstetrics and Gynecology and Department of Health Technologies as well as the director of two core research facilities for Augusta University (Genomics, Proteomics & Mass Spectrometry). In his long academic career, he has authored over 400-peer reviewed papers with an H-Index of 76 and over 19,000 citations, secured over $100 million in research grants, has been invited to speak globally.  He mentored a large number of doctoral students, post-docs and faculty members. Dr. She is one of the 20 “Georgia Top Medical Researchers”.  He served as President of the Chinese Geneticists in America and President of the American Diabetes Association's council on Immunology, transplantation and Immunogenetics among other honors.  Dr. She is a serial entrepreneur and has founded or co-founded multiple companies in the US and China. He is the founder and CEO of Jinfiniti Precision Medicine, a company dedicated to optimizing healthspan through biomarker testing and precision nutraceuticals. More information can be found on Jin-Xiong She' LinkedIn Profile and Jin-Xiong She's Google Scholar Profile. Boying DunPhD, co-Founder & Chief Innovation OfficerBob ThordarsonChief Technology OfficerMichael HeckPhD, CLIA Clinical Laboratory Director

Life Science Success
Dr. Mohit Jain Unveils Next-Gen Tech in Drug Discovery & Therapy

Life Science Success

Play Episode Listen Later Apr 6, 2024 34:38


In this episode of Life Science Success, host Don Davis has a conversation with Dr. Mohit Jain, a physician scientist with extensive experience in physiology, biomedicine, and mass spectrometry. Dr. Jain shares his unique journey from clinical training to leading breakthroughs in mass spectrometry and computational biology. He discusses the inception of Sapient Bio, a company that leverages mass spectrometry to unlock new horizons in drug discovery and patient diagnosis by analyzing thousands of molecules in the human body. They explore the future of medicine, emphasizing personalized therapy and the potential to diagnose diseases like diabetes and Alzheimer's years in advance. Dr. Jain also sheds light on the challenges and opportunities in biotech, the impact of computational biology, and the pivotal role of Sapient Bio in pioneering the field of drug discovery. The conversation concludes with Dr. Jain's reflections on leadership, inspiration, concerns, and what excites him about his work, offering deep insights into the promising future of life sciences.   Key Highlights:  01:23 Introducing Dr. Mohit Jain: A Multifaceted Scientist 02:04 The Journey to Sapient Bio: Unraveling Dr. Jain's Career Path 03:39 The Evolution of Mass Spectrometry and Its Impact on Health 06:45 Sapient Bio: Democratizing Access to Advanced Technologies 13:33 Challenges and Opportunities in Leading a Biotech Company 16:54 The Future of Drug Discovery and Personalized Medicine 23:47 Sapient Bio's Differentiation and Future Prospects 29:24 Leadership Insights and Personal Reflections from Dr. Jain    

Blood Podcast
Free light chain mass spectrometry in diagnosis and monitoring of AL amyloidosis; T cells of AML patients in remission have distinct RNA signatures; and protective effect of ADAMTS13 in sickle cell mice depends on von Willebrand factor clearance

Blood Podcast

Play Episode Listen Later Mar 28, 2024 22:34


In this week's episode we'll discuss the findings from a study assessing the utility of free light chain mass spectrometry in AL amyloidosis, learn more about distinct single-cell RNA-sequencing signatures of bone marrow T cells of AML patients in remission after an allogeneic stem cell transplant, and discuss why von Willebrand factor clearance is critical for the protective effect of ADAMTS13 in mice with sickle cell anemia.Articles featured in this episode: Clearance of VWF by hepatic macrophages is critical for the protective effect of ADAMTS13 in sickle cell anemia mice Complete responses in AL amyloidosis are unequal: the impact of free light chain mass spectrometry in AL amyloidosisThe remission status of patients with AML post-alloSCT is associated with a distinct single-cell bone marrow T-cell signature 

The Addiction Podcast - Point of No Return
Michael Gray Fentanyl and the Poisoning of America

The Addiction Podcast - Point of No Return

Play Episode Listen Later Mar 14, 2024 44:22


Michael Gray is the CEO of Actus Analytical, Inc., which develops spectroscopy solutions for public safety compliance, illicit drug detection, agricultural productivity, and other applications. Michael and his wife Nancy founded The Actus Foundation, a 501(c)(3) charitable organization, in 2018. The Actus Foundation advocates for solutions to treating the entirety of the overdose epidemic problem in America, including the largely forgotten constituency of intermittent users. He founded, with partner Ed Kobilis in 2019, the Fentanyl Awareness Coalition - a coalition of tens of thousands of advocates in the US. Michael is a popular speaker, offering unique analyses and suggestions for creative solutions to a new problem, i.e., an old problem with a recently altered paradigm. Michael walks participants through the murky world of the drug problem clarifying the threat and dispelling myths. The Actus Foundation also advocates for the mentally ill, striving to deliver the message that mental illness is a disease the entire family suffers, and suffers in isolation; there are no well-worn paths to solutions available to those in chronic states of mental illness. For all our success in medical science – diagnostic practices, treatment/care and patient advocacy – our nation has left behavioral science in the stone age. Our practice of psychiatric care – diagnostic practices, treatment/care and patient advocacy – is the ugly stepchild hidden in the attic as the country proudly displays her medical science wonders to the world. In addition to advocacy, Mr. Gray is offering his 35 years of professional expertise in the world of scientific instrumentation as another element of his work on behalf of the victims of overdose. As the Interdict Law and other legislative activity considers nascent technological advances in the ability to detect illicit drugs at the street level, Michael adds his professional expertise to that debate. With experience in the areas of Infrared Spectroscopy and Mass Spectrometry, Michael is participating in the development and deployment of portable testing for narcotics, at the field level, as a means of confirming suspected illegal substances and protecting First Responders. HELP SUPPORT OUR FIGHT AGAINST ADDICTION. DONATE HERE: https://www.patreon.com/theaddictionpodcast   PART OF THE GOOD NEWS PODCAST NETWORK. AUDIO VERSIONS OF ALL OUR EPISODES: https://theaddictionpodcast.com CONTACT US: The Addiction Podcast - Point of No Return theaddictionpodcast@yahoo.com Intro and Outro music by: Decisions by Kevin MacLeod is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/by/4.0/ Source: http://incompetech.com/music/royalty-free/index.html?isrc=USUAN1100756 Artist: http://incompetech.com/

DMPK Insights
DMPK Insights #6: Protein Mass Spectrometry: Advancing the Bioanalysis of Biotherapeutics and Biomarkers

DMPK Insights

Play Episode Listen Later Mar 6, 2024 39:33


In this podcast, Scott and John will discuss the LC-MS techniques that have been applied for the bioanalysis of biotherapeutics.The episode explores the following:The impact that mass spectrometry is having in the biotherapeutics and biomarker spaceThe rationale behind the use of LC-MS for certain biomarkers and how sensitive LC-MS assays can be developed (and the practical limits for lower limits of quantification that can be achieved)Developments in mass spectrometry that are expected to benefit the analysis of biomarkers and for biotherapeuticsSpeaker:John Mehl – Consultant John Mehl is currently consulting and previously worked as a director at GSK, leading the Protein MS group within the Bioanalysis, Immunogenicity and Biomarkers (BIB) department, Collegeville, PA. The group developed LC-MS assays for quantitative & qualitative analysis of biopharmaceuticals, protein & small molecule biomarkers and for the determination of in vivo protein turnover kinetics to support preclinical and clinical studies. Prior to joining GSK, John worked for BMS where he was a Sr. Principal Scientist focused on biomarker & large molecule quantification and characterization using MS.  John has a PhD degree in analytical chemistry from Vanderbilt University, postdoctoral training in protein MS from MIT and an MBA in business management from Temple University.  Before joining BMS, John worked for Merck in different analytical research areas including proteomics, small molecule DMPK, large molecule immunoassay method development and vaccine and biologics protein characterization, spanning both discovery and regulated laboratories.  He has published extensively on the use of hybrid LC-MS for both large and small molecule quantification.Stay tuned for more podcasts in our Pharmaron DMPK Insights Series!

BTBA presents: 生技來一刻
新型態細胞療法:當免疫細胞遇上點擊化學 ft. 蕭世嘉博士

BTBA presents: 生技來一刻

Play Episode Listen Later Jan 16, 2024 75:11


無數科學家們研究並開發新的治療方法來對付癌症,這個令人聞之色變的疾病。從早期的非專一性的化學和放射線治療,到約西元 2000 年出現的標靶療法 (targeted therapy),以及過去十年開始興盛的免疫療法 (immunotherapy) 等,每一步都是跟癌症對抗的重要里程碑。而從 2017 年 FDA 核准六款 CAR-T (Chimeric Antigen Receptor T-cell) 細胞療法之後,CAR-T 細胞療法成為癌症研究和治療的一大主流方向。與此同時,目前核准的 CAR-T 療法需要從病人身上取得 T 細胞,改造後放回病人體內,高度客製化的要求導致療程的費用高昂;另外,目前的療法使用病毒將遺傳物質帶入取出的 T 細胞,以表達特定受體,但並非所有細胞都能承受這樣的改造流程,種種原因限制了 CAR-T 療法在臨床治療的影響力。 針對這些現有療法的不足,蕭世嘉博士創辦的育世博公司另闢蹊徑,將點擊化學(此技術獲2022年諾貝爾化學獎)應用在免疫細胞改造,避免了一些免疫細胞經病毒改造後失去活性的限制,並成功開發兩款改造 T 細胞進入臨床試驗。 想知道一般免疫細胞為何需要做專一性抗體修飾,育世博的抗體細胞連結技術 (Antibody Cell Conjugate, ACC) 和之前的改造方法相比還有何優勢,以及創辦新公司需要考慮哪些因素,千萬不要錯過這集精彩的訪談!  

#ExpertAnswers - an InsideScientific Podcast
#ExpertAnswers: Jeffrey Silva and Matthew Stokes on Mass Spectrometry-Based Proteomics

#ExpertAnswers - an InsideScientific Podcast

Play Episode Listen Later Jan 2, 2024 17:47


Experts from Cell Signaling Technology answer questions from a recent webinar on mass spectrometry-based proteomics.

Science with a Twist
Decoding Cellular Secrets: Advances in Mass Spectrometry Technology

Science with a Twist

Play Episode Listen Later Dec 21, 2023 19:31


Revolutionizing Biomedical Research with Mass SpectrometryJoshua J. Coon discusses the transformative role of mass spectrometry in biomedical research. This technology, as he explains, allows for the precise weighing of molecules, providing critical insights into their identity and quantity. Coon's lab utilizes mass spectrometry to analyze complex biological systems, such as cells and tissues, identifying over 10,000 molecules in a single sample. This capability has significant implications for understanding genetic and lifestyle influences on molecular behavior in organisms. Coon's work exemplifies how a fundamental scientific tool can lead to profound discoveries in disease mechanisms and potential treatments. Linking Unknown Proteins to Disease: A New FrontierCoon highlights a groundbreaking project where his team investigates proteins of unknown function, particularly those involved in metabolism and located in mitochondria. By creating cell lines with each lacking a different protein and then using mass spectrometry to analyze the resulting molecular changes, they can infer relationships between known and unknown proteins. This approach has led to identifying the functions of several proteins and linking them to specific human disorders. This research is not only pioneering in its method but also crucial in laying the groundwork for new therapies, as understanding protein functions can lead to targeted drug development. Personal Journey: From Rural Roots to Research LeaderJoshua J. Coon shares his personal journey, beginning in rural Michigan, where his early interests in science and woodworking led him to the field of mass spectrometry. His path took him through the University of Florida for his PhD and the University of Virginia for postdoctoral studies, culminating in leading his research group at the University of Wisconsin-Madison. Joshua emphasizes the joy of training the next generation of scientists, with his lab producing over 50 PhD students and postdocs who are now contributing significantly to science globally. This insight not only sheds light on Coon's professional achievements but also highlights his role in mentoring and shaping future scientific leaders.

Clinical Chemistry Podcast
Sensitive Blood-Based Detection of HIV-1 and Mycobacterium tuberculosis Peptides for Disease Diagnosis by Immuno-Affinity Liquid Chromatography–Tandem Mass Spectrometry: A Method Development and Proof-of-Concept Study

Clinical Chemistry Podcast

Play Episode Listen Later Dec 1, 2023 9:13


Stuff You Missed in History Class
Unearthed! in Autumn 2023, Part 2

Stuff You Missed in History Class

Play Episode Listen Later Oct 18, 2023 37:14 Transcription Available


Part two of our autumn 2023 edition of Unearthed! includes potpourri, repatriations, shipwrecks, art, and a few perfect October entries. Research:  “Early humans deliberately made mysterious stone 'spheroids'.” PhysOrg. 9/10/2023. https://phys.org/news/2023-09-early-humans-deliberately-mysterious-stone.html Alutiiq Museum. “Archaeologists Recover 3,000-year-old Weavings from Ancestral Alutiiq Settlement.” Alaska Native News. 8/26/2023. https://alaska-native-news.com/archaeologists-recover-3000-year-old-weavings-from-ancestral-alutiiq-settlement/69558/ Australian National Maritime Museum. “Exploring South Australia's oldest shipwreck.” Phys.org. 8/15/2023. https://phys.org/news/2023-08-exploring-south-australia-oldest-shipwreck.html Barker, Christopher. “Stolen van Gogh Painting Worth Millions Returned in an Ikea Bag.” Smithsonian. 9/14/2023. https://www.smithsonianmag.com/smart-news/dutch-art-detective-recovers-a-van-gogh-stolen-in-2020-180982896/ BBC News. “Man finds 8,000-year-old dolphin bones in back garden.” 7/31/2023. https://www.bbc.com/news/uk-scotland-tayside-central-66361506 BBC News. “Tiny Roman dog remains found during Oxford archaeological dig.” 7/25/2023. https://www.bbc.com/news/uk-england-oxfordshire-66294261 Beazley, Jordan. “ANU museum to hand back stolen 2,500-year-old vase to Italy.” The Guardian. 9/13/2023. https://www.theguardian.com/artanddesign/2023/sep/14/anu-to-return-2500-year-old-vase-to-italy-after-link-to-art-trade-exposed Bebber, Michelle R. et al. “Atlatl use equalizes female and male projectile weapon velocity.” Scientific Reports. 8/16/2023. https://www.nature.com/articles/s41598-023-40451-8 Beimfohr, Chelsea. “109-year-old survivor of Tulsa Race Massacre pens new book, speaks at King Center.” Atlanta News First. 9/26/2023. https://www.atlantanewsfirst.com/2023/09/27/109-year-old-survivor-tulsa-race-massacre-pens-new-book-speaks-king-center/ Ben Crump. “Ben Crump and Family of Henrietta Lacks Announce Settlement.” https://bencrump.com/press/family-of-henrietta-lacks-announce-settlement/ Binswanger, Julia. “Forgotten Winnie-the-Pooh Sketch Found Wrapped in an Old Tea Towel.” Smithsonian. 8/28/2023. https://www.smithsonianmag.com/smart-news/winnie-the-pooh-sketch-wrapped-tea-towel-180982800/ Briseida MEMA. “Archaeologists uncover Europe's oldest stilt village.” Phys.org. 8/11/2023. https://phys.org/news/2023-08-archaeologists-uncover-europe-oldest-stilt.html British Library Medieval Manuscripts Blog. “Showing Elizabeth I in a new light.” 7/15/2023. https://blogs.bl.uk/digitisedmanuscripts/2023/07/showing-elizabeth-i-in-a-new-light.html British Library Press Office. “British Library researcher throws new light on Elizabeth I.” July 2023. https://www.bl.uk/press-releases/2023/july/British-Library-researcher-throws-new-light-on-Elizabeth-I?utm_source=twitter&utm_medium=social&utm_campaign=press&utm_content=camdens_annals#:~:text=Helena%20Rutkowska%2C%20DPhil%20student%20at,to%20explore%20hundreds%20of%20previously Cell Press. “Ancient metal cauldrons give us clues about what people ate in the Bronze Age.” 8/18/2023. https://phys.org/news/2023-08-ancient-metal-cauldrons-clues-people.html Chappell, Bill. “Iconic female artist's lost painting is found, hundreds of years after it was created.” NPR. 9/25/2023. https://www.npr.org/2023/09/25/1201501653/artemisia-gentileschi-susanna-and-the-elders Cin, Muharrem. “Makeup materials from Roman era unearthed in ancient city of Aizanoi in Türkiye.” Andalou Agency. 9/24/2023. https://www.aa.com.tr/en/culture/makeup-materials-from-roman-era-unearthed-in-ancient-city-of-aizanoi-in-turkiye/2999909 Delgado, Maria Jesus. “Oldest hunter-gatherer basketry in southern Europe, 9,500 years old, discovered in Cueva de los Murciélagos, Albuñol (Granada, Spain).” EurekAlert. 9/28/2023. https://www.eurekalert.org/news-releases/1003066 Dowell, Stuart. “Ghoulish remains of ‘vampire child' found in ‘grave of the damned'.” The First News. 8/7/2023. https://www.thefirstnews.com/article/ghoulish-remains-of-vampire-child-found-in-grave-of-the-damned-40397 Efford M, Taft S, Morin J, George M, George M, Cavers H, et al. (2023) Archaeology demonstrates sustainable ancestral Coast Salish salmon stewardship over thousands of years. PLoS ONE 18(8): e0289797. https://doi.org/10.1371/journal.pone.0289797 Flavell, Julie. “The Dog Who Served on Both Sides of the American Revolution.” Smithsonian Magazine. 8/25/2023. https://www.smithsonianmag.com/history/the-dog-who-served-on-both-sides-of-the-american-revolution-180982781/ Gillett, Francesca. “Ancient 2,000-year-old Roman shipwreck found off coast of Italy.” BBC News. 7/28/2023. https://www.bbc.com/news/world-europe-66337902 Gorski, “119-year overdue book returned by WVU Library.” 12WBOY. 7/27/2023. https://www.wboy.com/news/monongalia/west-virginia-university/library-book-returned-and-it-was-only-119-years-overdue/ Handwerk, Brian. “Famed 5,300-Year-Old Alps Iceman Was a Balding Middle-Aged Man With Dark Skin and Eyes.” Smithsonian. 8/16/2023. https://www.smithsonianmag.com/science-nature/famed-5300-year-old-alps-iceman-was-a-balding-middle-aged-man-with-dark-skin-and-eyes-180982744/ Hanson's. “Panko game made to aid suffragettes a century ago found during house clearance.” 7/18/2023. https://hansonsauctioneers.co.uk/panko-game-made-to-aid-suffragettes-a-century-ago-found-during-house-clearance/ Jarus, Owen. “2,200-year-old remains of sacrificed giant panda and tapir discovered near Chinese emperor's tomb.” LiveScience. 8/18/2023. https://www.livescience.com/archaeology/2200-year-old-remains-of-sacrificed-giant-panda-and-tapir-discovered-near-chinese-emperors-tomb Kent State University. “Atlatl weapon use by prehistoric females equalized the division of labor while hunting, experimental study shows.” 8/18/2023. https://phys.org/news/2023-08-atlatl-weapon-prehistoric-females-equalized.html Kindy, Dave. “Piece of wood found at garage sale was part of the sunken USS Maine.” Washington Post. 9/17/2023. https://www.washingtonpost.com/history/2023/09/17/uss-maine-mast-arlington-cemetery/ Kuta, Sarah. “‘Perfectly Preserved' Glassware Recovered From 2,000-Year-Old Shipwreck.” Smithsonian. 7/27/2023. https://www.smithsonianmag.com/smart-news/glassware-2000-year-old-roman-shipwreck-180982615/ Kuta, Sarah. “See Underwater Wreckage From the Battle of Midway in Stunning Detail.” Smithsonian. 9/22/2023. https://www.smithsonianmag.com/smart-news/battle-of-midway-shipwreck-photos-180982938/ Lawson-Tancred, Jo. “A Virginia Museum Repatriated a Nigerian Sculpture and Received a High-Tech Replica in Return. Could the Exchange Shape Future Restitutions?” ArtNet. 7/7/2023. https://news.artnet.com/art-world/chrysler-museum-factum-foundation-high-tech-facsimile-restitution-2332938 Lawson-Tancred, Jo. “A Woman Bought a $4 Painting at a Thrift Store for Its Frame. Now, It's Been Revealed as an N.C. Wyeth, Worth as Much as $250,000.” ArtNet. 9/6/2023. https://news.artnet.com/market/thrift-store-buy-nc-wyeth-2355493 Lawson-Tancred, Jo. “Two 10th-Century Stone Idols, Which Were Stolen From a Temple in India and Found in a Garden Shed in the U.K., Will Be Repatriated.” ArtNet. https://news.artnet.com/art-world/10th-century-idols-found-in-garden-shed-returned-to-india-2335670 Massachusetts Institute of Technology. “Ancient Amazonians intentionally created fertile 'dark earth.'” Science Daily. 9/20/2023. https://www.sciencedaily.com/releases/2023/09/230920152306.htm Max Planck Institute of Geoanthropology. “The scent of the afterlife unbottled in new study of ancient Egyptian mummification balms.” Science Daily. 8/31/2023. https://www.sciencedaily.com/releases/2023/08/230831121651.htm Mayorquin, Orlando. “Overdue Book Is Returned to a Library After Nearly 120 Years.” New York Times. 7/9/2023. https://www.nytimes.com/2023/07/09/us/massachusetts-overdue-book-119-years.html net. “Strange burial of 9th-century teenager reveals tragic story.” https://www.medievalists.net/2023/08/strange-burial-of-9th-century-teenager-reveals-tragic-story/ Miller, Ken. “Researchers exhume seven sets of remains in search for Tulsa Race Massacre victims.” The Oklahoman. 10/2/2023. https://www.oklahoman.com/story/news/2023/10/02/tulsa-race-massacre-oklahoma-seven-graves-exhumed/71036617007/ MOLA Headland. “An Unusual Burial and a Tragic Story from Early Medieval Cambridgeshire.” 8/14/2023. https://molaheadland.com/an-unusual-burial-and-a-tragic-story-from-early-medieval-cambridgeshire/ Nowakowski, Teresa. “Historians Discover ‘Remarkably Intact' Shipwreck, Undisturbed Beneath Lake Michigan for 142 Years.” Smithsonian. 9/6/2023. https://www.smithsonianmag.com/smart-news/archaeologists-discover-an-almost-entirely-intact-142-year-old-shipwreck-in-lake-michigan-180982848/ Nowakowski, Teresa. “The Netherlands Repatriates Nearly 500 Looted Artifacts to Sri Lanka and Indonesia.” Smithsonian. 7/11/2023. https://www.smithsonianmag.com/smart-news/netherlands-repatriation-sri-lanka-indonesia-180982514/ Osborne, Margaret. “Archaeologists Uncover Oldest Evidence of ‘Curry' Outside of India.” Smithsonian. 7/24/2023. https://www.smithsonianmag.com/smart-news/archaeologists-uncover-oldest-evidence-of-curry-outside-of-india-180982589/ Parker, Christopher. “4,000-Year-Old Cemetery Discovered Beneath Future Rocket Launch Pad in U.K.” Smithsonian. 8/1/2023. https://www.smithsonianmag.com/smart-news/bronze-age-cemetery-rocket-launch-uk-180982633/ Parker, Christopher. “Divers Pull Wreckage of Tuskegee Airman's Plane From the Depths of Lake Huron.” Smithsonian. 9/5/2023. https://www.smithsonianmag.com/smart-news/divers-haul-engine-of-tuskegee-airmans-plane-from-lake-huron-180982845/ Parker, Christopher. “Manchester Museum Returns 174 Artifacts to Indigenous Australians.” Smithsonian. 9/7/2023. https://www.smithsonianmag.com/smart-news/manchester-museum-returns-174-artifacts-to-indigenous-austrailians-180982853/ Pendergraff, Gavin. “State archaeologist provides another update on excavation work in Tulsa.” KTUL. 9/14/2023. https://ktul.com/news/local/state-archaeologist-provides-another-update-on-excavation-work-in-tulsa Pittalà, Maria Gaetana Giovanna et al. “Count Dracula Resurrected: Proteomic Analysis of Vlad III the Impaler's Documents by EVA Technology and Mass Spectrometry.” Anal. Chem. 2023, 95, 34, 12732–12744. Publication Date: August 8, 2023. https://doi.org/10.1021/acs.analchem.3c01461 Potter, Lisa. “Daughters breastfed longer, and women accumulated greater wealth in ancient California matriarchal society.” EurekAlert. 7/12/2023. https://www.eurekalert.org/news-releases/995404 Public Library of Science. “Stone Age artists carved detailed human and animal tracks in rock art in Namibia.” 9/13/2023. PhysOrg. https://phys.org/news/2023-09-stone-age-artists-human-animal.html Ritter, Moira. “Detailed mosaic floor — with Medusa's face — unearthed in ancient Roman villa.” Miami Herald. 7/27/2023. https://www.miamiherald.com/news/nation-world/world/article277706663.html#storylink=cpy Royal Collection Trust. “Lost Artemisia Gentileschi Painting Rediscovered in the Royal Collection.” 9/24/2023. https://www.rct.uk/about/press-office/press-releases/lost-artemisia-gentileschi-painting-rediscovered-in-the-royal#/ Schrader, Adam. “British Museum Director Hartwig Fischer Will Step Down, Leaving the Unresolved Parthenon Marbles Debate to His Successor.” ArtNews. 7/28/2023. https://news.artnet.com/art-world/british-museum-director-hartwig-fischer-step-down-next-year-2342951 Schuster, Ruth. “Synagogue From Late Second Temple Period Found by Black Sea in Russia.” Haaretz. 8/16/2023. https://www.haaretz.com/archaeology/2023-08-16/ty-article-magazine/synagogue-from-late-second-temple-period-found-by-black-sea-in-russia/00000189-fae4-d0b9-a5a9-ffef91b90000 Shaw, Garry. “‘Thunder floor' found at ancient Andean site in Peru.” The Art Newspaper. 7/18/2023. https://www.theartnewspaper.com/2023/07/18/ancient-dance-floor-sounding-platform-andes-peru-archaeological-discovery Solly, Meilan. “Hidden for 400 Years, Censored Pages Reveal New Insights Into Elizabeth I's Reign.” Smithsonian. 7/18/2023. https://www.smithsonianmag.com/smart-news/hidden-for-400-years-censored-pages-reveal-new-insights-on-elizabeth-is-reign-180982554/ Sullivan, Will. “Archaeologists Uncover Notched Logs That May Be the Oldest Known Wooden Structure.” Smithsonian. 9/22/2023. https://www.smithsonianmag.com/smart-news/archaeologists-uncover-notched-logs-that-may-be-the-oldest-known-wooden-structure-180982942/ Sullivan, Will. “Henrietta Lacks' Family Settles Lawsuit Over the Use of Her Cells Without Consent.” Smithsonian. 8/2/2023. https://www.smithsonianmag.com/smart-news/henrietta-lacks-family-settles-lawsuit-over-the-use-of-her-cells-without-consent-180982644/ The History Blog. “14th c. shipwreck cannon may be oldest in Europe.” 9/13/2023. http://www.thehistoryblog.com/archives/68252 The History Blog. “2,000-year-old synagogue found in southern Russia.” 8/16/2023. http://www.thehistoryblog.com/archives/68050 The History Blog. “8-year-old finds 1,800-year-old silver denarius in school sandbox.” http://www.thehistoryblog.com/archives/68120 The History Blog. “Giant panda found in Western Han imperial tomb.” 8/6/2023. http://www.thehistoryblog.com/archives/67972 University of Geneva. “New discoveries on the wreck of Antikythera.” 7/24/2023. https://phys.org/news/2023-07-discoveries-antikythera.html University of Gothenburg. “Shipboard cannon found off the Swedish coast may be the oldest in Europe.” EurekAlert. 9/13/2023. https://www.eurekalert.org/news-releases/1001404 University of Montreal. “New evidence of plant food processing in Italy during Neanderthal-to-Homo sapiens period.” Phys.org. 6/29/2023. https://phys.org/news/2023-06-evidence-food-italy-neanderthal-to-homo-sapiens.html University of Southampton. “Archaeologists reveal largest palaeolithic cave art site in Eastern Iberia.” Science Daily. 9/11/2023. https://www.sciencedaily.com/releases/2023/09/230911141015.htm University of Valencia. “Pigment production adapted to cultural changes and availability of mineral resources 40,000 years ago in Ethiopia.” PhysOrg. 9/11/2023. https://phys.org/news/2023-09-pigment-production-cultural-availability-mineral.html Walls, Alex. “Salmon bones confirm sustainable chum fishery for 2,500 years under Tsleil-Waututh Nation.” PhysOrg. 8/30/2023. https://phys.org/news/2023-08-salmon-bones-sustainable-chum-fishery.html Watts, Rachel. “Divers find long-lost artifact from sunken Empress of Ireland in St. Lawrence River.” CBC. 9/9/2023. https://www.cbc.ca/news/canada/montreal/divers-find-long-lost-artifact-from-sunken-empress-of-ireland-quebec-compass-platform-1.6959176 Weiwei Wang et al. ,Earliest curry in Southeast Asia and the global spice trade 2000 years ago.Sci. Adv.9,eadh5517(2023).DOI:10.1126/sciadv.adh5517 Yirka, Bob. “Arrowhead housed at Bern History Museum found to be made from meteoritic iron.” Phys.org. 7/31/2023. https://phys.org/news/2023-07-arrowhead-housed-bern-history-museum.html Yirka, Bob. “Placement of ancient hidden lamps, skulls in cave in Israel suggests Roman-era practice of necromancy.” Phys.org. 7/14/2023. https://phys.org/news/2023-07-placement-ancient-hidden-lamps-skulls.html    See omnystudio.com/listener for privacy information.

Stuff You Missed in History Class
Unearthed! in Autumn 2023, Part 1

Stuff You Missed in History Class

Play Episode Listen Later Oct 16, 2023 40:58 Transcription Available


In part one of our Autumn 2023 edition of Unearthed!, we have some oldest things, books and letters, projects specifically related to gender, edibles and potables, and animals.  Research:  “Early humans deliberately made mysterious stone 'spheroids'.” PhysOrg. 9/10/2023. https://phys.org/news/2023-09-early-humans-deliberately-mysterious-stone.html Alutiiq Museum. “Archaeologists Recover 3,000-year-old Weavings from Ancestral Alutiiq Settlement.” Alaska Native News. 8/26/2023. https://alaska-native-news.com/archaeologists-recover-3000-year-old-weavings-from-ancestral-alutiiq-settlement/69558/ Australian National Maritime Museum. “Exploring South Australia's oldest shipwreck.” Phys.org. 8/15/2023. https://phys.org/news/2023-08-exploring-south-australia-oldest-shipwreck.html Barker, Christopher. “Stolen van Gogh Painting Worth Millions Returned in an Ikea Bag.” Smithsonian. 9/14/2023. https://www.smithsonianmag.com/smart-news/dutch-art-detective-recovers-a-van-gogh-stolen-in-2020-180982896/ BBC News. “Man finds 8,000-year-old dolphin bones in back garden.” 7/31/2023. https://www.bbc.com/news/uk-scotland-tayside-central-66361506 BBC News. “Tiny Roman dog remains found during Oxford archaeological dig.” 7/25/2023. https://www.bbc.com/news/uk-england-oxfordshire-66294261 Beazley, Jordan. “ANU museum to hand back stolen 2,500-year-old vase to Italy.” The Guardian. 9/13/2023. https://www.theguardian.com/artanddesign/2023/sep/14/anu-to-return-2500-year-old-vase-to-italy-after-link-to-art-trade-exposed Bebber, Michelle R. et al. “Atlatl use equalizes female and male projectile weapon velocity.” Scientific Reports. 8/16/2023. https://www.nature.com/articles/s41598-023-40451-8 Beimfohr, Chelsea. “109-year-old survivor of Tulsa Race Massacre pens new book, speaks at King Center.” Atlanta News First. 9/26/2023. https://www.atlantanewsfirst.com/2023/09/27/109-year-old-survivor-tulsa-race-massacre-pens-new-book-speaks-king-center/ Ben Crump. “Ben Crump and Family of Henrietta Lacks Announce Settlement.” https://bencrump.com/press/family-of-henrietta-lacks-announce-settlement/ Binswanger, Julia. “Forgotten Winnie-the-Pooh Sketch Found Wrapped in an Old Tea Towel.” Smithsonian. 8/28/2023. https://www.smithsonianmag.com/smart-news/winnie-the-pooh-sketch-wrapped-tea-towel-180982800/ Briseida MEMA. “Archaeologists uncover Europe's oldest stilt village.” Phys.org. 8/11/2023. https://phys.org/news/2023-08-archaeologists-uncover-europe-oldest-stilt.html British Library Medieval Manuscripts Blog. “Showing Elizabeth I in a new light.” 7/15/2023. https://blogs.bl.uk/digitisedmanuscripts/2023/07/showing-elizabeth-i-in-a-new-light.html British Library Press Office. “British Library researcher throws new light on Elizabeth I.” July 2023. https://www.bl.uk/press-releases/2023/july/British-Library-researcher-throws-new-light-on-Elizabeth-I?utm_source=twitter&utm_medium=social&utm_campaign=press&utm_content=camdens_annals#:~:text=Helena%20Rutkowska%2C%20DPhil%20student%20at,to%20explore%20hundreds%20of%20previously Cell Press. “Ancient metal cauldrons give us clues about what people ate in the Bronze Age.” 8/18/2023. https://phys.org/news/2023-08-ancient-metal-cauldrons-clues-people.html Chappell, Bill. “Iconic female artist's lost painting is found, hundreds of years after it was created.” NPR. 9/25/2023. https://www.npr.org/2023/09/25/1201501653/artemisia-gentileschi-susanna-and-the-elders Cin, Muharrem. “Makeup materials from Roman era unearthed in ancient city of Aizanoi in Türkiye.” Andalou Agency. 9/24/2023. https://www.aa.com.tr/en/culture/makeup-materials-from-roman-era-unearthed-in-ancient-city-of-aizanoi-in-turkiye/2999909 Delgado, Maria Jesus. “Oldest hunter-gatherer basketry in southern Europe, 9,500 years old, discovered in Cueva de los Murciélagos, Albuñol (Granada, Spain).” EurekAlert. 9/28/2023. https://www.eurekalert.org/news-releases/1003066 Dowell, Stuart. “Ghoulish remains of ‘vampire child' found in ‘grave of the damned'.” The First News. 8/7/2023. https://www.thefirstnews.com/article/ghoulish-remains-of-vampire-child-found-in-grave-of-the-damned-40397 Efford M, Taft S, Morin J, George M, George M, Cavers H, et al. (2023) Archaeology demonstrates sustainable ancestral Coast Salish salmon stewardship over thousands of years. PLoS ONE 18(8): e0289797. https://doi.org/10.1371/journal.pone.0289797 Flavell, Julie. “The Dog Who Served on Both Sides of the American Revolution.” Smithsonian Magazine. 8/25/2023. https://www.smithsonianmag.com/history/the-dog-who-served-on-both-sides-of-the-american-revolution-180982781/ Gillett, Francesca. “Ancient 2,000-year-old Roman shipwreck found off coast of Italy.” BBC News. 7/28/2023. https://www.bbc.com/news/world-europe-66337902 Gorski, “119-year overdue book returned by WVU Library.” 12WBOY. 7/27/2023. https://www.wboy.com/news/monongalia/west-virginia-university/library-book-returned-and-it-was-only-119-years-overdue/ Handwerk, Brian. “Famed 5,300-Year-Old Alps Iceman Was a Balding Middle-Aged Man With Dark Skin and Eyes.” Smithsonian. 8/16/2023. https://www.smithsonianmag.com/science-nature/famed-5300-year-old-alps-iceman-was-a-balding-middle-aged-man-with-dark-skin-and-eyes-180982744/ Hanson's. “Panko game made to aid suffragettes a century ago found during house clearance.” 7/18/2023. https://hansonsauctioneers.co.uk/panko-game-made-to-aid-suffragettes-a-century-ago-found-during-house-clearance/ Jarus, Owen. “2,200-year-old remains of sacrificed giant panda and tapir discovered near Chinese emperor's tomb.” LiveScience. 8/18/2023. https://www.livescience.com/archaeology/2200-year-old-remains-of-sacrificed-giant-panda-and-tapir-discovered-near-chinese-emperors-tomb Kent State University. “Atlatl weapon use by prehistoric females equalized the division of labor while hunting, experimental study shows.” 8/18/2023. https://phys.org/news/2023-08-atlatl-weapon-prehistoric-females-equalized.html Kindy, Dave. “Piece of wood found at garage sale was part of the sunken USS Maine.” Washington Post. 9/17/2023. https://www.washingtonpost.com/history/2023/09/17/uss-maine-mast-arlington-cemetery/ Kuta, Sarah. “‘Perfectly Preserved' Glassware Recovered From 2,000-Year-Old Shipwreck.” Smithsonian. 7/27/2023. https://www.smithsonianmag.com/smart-news/glassware-2000-year-old-roman-shipwreck-180982615/ Kuta, Sarah. “See Underwater Wreckage From the Battle of Midway in Stunning Detail.” Smithsonian. 9/22/2023. https://www.smithsonianmag.com/smart-news/battle-of-midway-shipwreck-photos-180982938/ Lawson-Tancred, Jo. “A Virginia Museum Repatriated a Nigerian Sculpture and Received a High-Tech Replica in Return. Could the Exchange Shape Future Restitutions?” ArtNet. 7/7/2023. https://news.artnet.com/art-world/chrysler-museum-factum-foundation-high-tech-facsimile-restitution-2332938 Lawson-Tancred, Jo. “A Woman Bought a $4 Painting at a Thrift Store for Its Frame. Now, It's Been Revealed as an N.C. Wyeth, Worth as Much as $250,000.” ArtNet. 9/6/2023. https://news.artnet.com/market/thrift-store-buy-nc-wyeth-2355493 Lawson-Tancred, Jo. “Two 10th-Century Stone Idols, Which Were Stolen From a Temple in India and Found in a Garden Shed in the U.K., Will Be Repatriated.” ArtNet. https://news.artnet.com/art-world/10th-century-idols-found-in-garden-shed-returned-to-india-2335670 Massachusetts Institute of Technology. “Ancient Amazonians intentionally created fertile 'dark earth.'” Science Daily. 9/20/2023. https://www.sciencedaily.com/releases/2023/09/230920152306.htm Max Planck Institute of Geoanthropology. “The scent of the afterlife unbottled in new study of ancient Egyptian mummification balms.” Science Daily. 8/31/2023. https://www.sciencedaily.com/releases/2023/08/230831121651.htm Mayorquin, Orlando. “Overdue Book Is Returned to a Library After Nearly 120 Years.” New York Times. 7/9/2023. https://www.nytimes.com/2023/07/09/us/massachusetts-overdue-book-119-years.html net. “Strange burial of 9th-century teenager reveals tragic story.” https://www.medievalists.net/2023/08/strange-burial-of-9th-century-teenager-reveals-tragic-story/ Miller, Ken. “Researchers exhume seven sets of remains in search for Tulsa Race Massacre victims.” The Oklahoman. 10/2/2023. https://www.oklahoman.com/story/news/2023/10/02/tulsa-race-massacre-oklahoma-seven-graves-exhumed/71036617007/ MOLA Headland. “An Unusual Burial and a Tragic Story from Early Medieval Cambridgeshire.” 8/14/2023. https://molaheadland.com/an-unusual-burial-and-a-tragic-story-from-early-medieval-cambridgeshire/ Nowakowski, Teresa. “Historians Discover ‘Remarkably Intact' Shipwreck, Undisturbed Beneath Lake Michigan for 142 Years.” Smithsonian. 9/6/2023. https://www.smithsonianmag.com/smart-news/archaeologists-discover-an-almost-entirely-intact-142-year-old-shipwreck-in-lake-michigan-180982848/ Nowakowski, Teresa. “The Netherlands Repatriates Nearly 500 Looted Artifacts to Sri Lanka and Indonesia.” Smithsonian. 7/11/2023. https://www.smithsonianmag.com/smart-news/netherlands-repatriation-sri-lanka-indonesia-180982514/ Osborne, Margaret. “Archaeologists Uncover Oldest Evidence of ‘Curry' Outside of India.” Smithsonian. 7/24/2023. https://www.smithsonianmag.com/smart-news/archaeologists-uncover-oldest-evidence-of-curry-outside-of-india-180982589/ Parker, Christopher. “4,000-Year-Old Cemetery Discovered Beneath Future Rocket Launch Pad in U.K.” Smithsonian. 8/1/2023. https://www.smithsonianmag.com/smart-news/bronze-age-cemetery-rocket-launch-uk-180982633/ Parker, Christopher. “Divers Pull Wreckage of Tuskegee Airman's Plane From the Depths of Lake Huron.” Smithsonian. 9/5/2023. https://www.smithsonianmag.com/smart-news/divers-haul-engine-of-tuskegee-airmans-plane-from-lake-huron-180982845/ Parker, Christopher. “Manchester Museum Returns 174 Artifacts to Indigenous Australians.” Smithsonian. 9/7/2023. https://www.smithsonianmag.com/smart-news/manchester-museum-returns-174-artifacts-to-indigenous-austrailians-180982853/ Pendergraff, Gavin. “State archaeologist provides another update on excavation work in Tulsa.” KTUL. 9/14/2023. https://ktul.com/news/local/state-archaeologist-provides-another-update-on-excavation-work-in-tulsa Pittalà, Maria Gaetana Giovanna et al. “Count Dracula Resurrected: Proteomic Analysis of Vlad III the Impaler's Documents by EVA Technology and Mass Spectrometry.” Anal. Chem. 2023, 95, 34, 12732–12744. Publication Date: August 8, 2023. https://doi.org/10.1021/acs.analchem.3c01461 Potter, Lisa. “Daughters breastfed longer, and women accumulated greater wealth in ancient California matriarchal society.” EurekAlert. 7/12/2023. https://www.eurekalert.org/news-releases/995404 Public Library of Science. “Stone Age artists carved detailed human and animal tracks in rock art in Namibia.” 9/13/2023. PhysOrg. https://phys.org/news/2023-09-stone-age-artists-human-animal.html Ritter, Moira. “Detailed mosaic floor — with Medusa's face — unearthed in ancient Roman villa.” Miami Herald. 7/27/2023. https://www.miamiherald.com/news/nation-world/world/article277706663.html#storylink=cpy Royal Collection Trust. “Lost Artemisia Gentileschi Painting Rediscovered in the Royal Collection.” 9/24/2023. https://www.rct.uk/about/press-office/press-releases/lost-artemisia-gentileschi-painting-rediscovered-in-the-royal#/ Schrader, Adam. “British Museum Director Hartwig Fischer Will Step Down, Leaving the Unresolved Parthenon Marbles Debate to His Successor.” ArtNews. 7/28/2023. https://news.artnet.com/art-world/british-museum-director-hartwig-fischer-step-down-next-year-2342951 Schuster, Ruth. “Synagogue From Late Second Temple Period Found by Black Sea in Russia.” Haaretz. 8/16/2023. https://www.haaretz.com/archaeology/2023-08-16/ty-article-magazine/synagogue-from-late-second-temple-period-found-by-black-sea-in-russia/00000189-fae4-d0b9-a5a9-ffef91b90000 Shaw, Garry. “‘Thunder floor' found at ancient Andean site in Peru.” The Art Newspaper. 7/18/2023. https://www.theartnewspaper.com/2023/07/18/ancient-dance-floor-sounding-platform-andes-peru-archaeological-discovery Solly, Meilan. “Hidden for 400 Years, Censored Pages Reveal New Insights Into Elizabeth I's Reign.” Smithsonian. 7/18/2023. https://www.smithsonianmag.com/smart-news/hidden-for-400-years-censored-pages-reveal-new-insights-on-elizabeth-is-reign-180982554/ Sullivan, Will. “Archaeologists Uncover Notched Logs That May Be the Oldest Known Wooden Structure.” Smithsonian. 9/22/2023. https://www.smithsonianmag.com/smart-news/archaeologists-uncover-notched-logs-that-may-be-the-oldest-known-wooden-structure-180982942/ Sullivan, Will. “Henrietta Lacks' Family Settles Lawsuit Over the Use of Her Cells Without Consent.” Smithsonian. 8/2/2023. https://www.smithsonianmag.com/smart-news/henrietta-lacks-family-settles-lawsuit-over-the-use-of-her-cells-without-consent-180982644/ The History Blog. “14th c. shipwreck cannon may be oldest in Europe.” 9/13/2023. http://www.thehistoryblog.com/archives/68252 The History Blog. “2,000-year-old synagogue found in southern Russia.” 8/16/2023. http://www.thehistoryblog.com/archives/68050 The History Blog. “8-year-old finds 1,800-year-old silver denarius in school sandbox.” http://www.thehistoryblog.com/archives/68120 The History Blog. “Giant panda found in Western Han imperial tomb.” 8/6/2023. http://www.thehistoryblog.com/archives/67972 University of Geneva. “New discoveries on the wreck of Antikythera.” 7/24/2023. https://phys.org/news/2023-07-discoveries-antikythera.html University of Gothenburg. “Shipboard cannon found off the Swedish coast may be the oldest in Europe.” EurekAlert. 9/13/2023. https://www.eurekalert.org/news-releases/1001404 University of Montreal. “New evidence of plant food processing in Italy during Neanderthal-to-Homo sapiens period.” Phys.org. 6/29/2023. https://phys.org/news/2023-06-evidence-food-italy-neanderthal-to-homo-sapiens.html University of Southampton. “Archaeologists reveal largest palaeolithic cave art site in Eastern Iberia.” Science Daily. 9/11/2023. https://www.sciencedaily.com/releases/2023/09/230911141015.htm University of Valencia. “Pigment production adapted to cultural changes and availability of mineral resources 40,000 years ago in Ethiopia.” PhysOrg. 9/11/2023. https://phys.org/news/2023-09-pigment-production-cultural-availability-mineral.html Walls, Alex. “Salmon bones confirm sustainable chum fishery for 2,500 years under Tsleil-Waututh Nation.” PhysOrg. 8/30/2023. https://phys.org/news/2023-08-salmon-bones-sustainable-chum-fishery.html Watts, Rachel. “Divers find long-lost artifact from sunken Empress of Ireland in St. Lawrence River.” CBC. 9/9/2023. https://www.cbc.ca/news/canada/montreal/divers-find-long-lost-artifact-from-sunken-empress-of-ireland-quebec-compass-platform-1.6959176 Weiwei Wang et al. ,Earliest curry in Southeast Asia and the global spice trade 2000 years ago.Sci. Adv.9,eadh5517(2023).DOI:10.1126/sciadv.adh5517 Yirka, Bob. “Arrowhead housed at Bern History Museum found to be made from meteoritic iron.” Phys.org. 7/31/2023. https://phys.org/news/2023-07-arrowhead-housed-bern-history-museum.html Yirka, Bob. “Placement of ancient hidden lamps, skulls in cave in Israel suggests Roman-era practice of necromancy.” Phys.org. 7/14/2023. https://phys.org/news/2023-07-placement-ancient-hidden-lamps-skulls.html    See omnystudio.com/listener for privacy information.

History Fix
Ep. 30 Dracula: How the Real Life Brutality of Vlad the Impaler Inspired the World's Most Famous Vampire

History Fix

Play Episode Listen Later Oct 8, 2023 32:32


Send us a Text Message.Picture a vampire. Yeah, you're picturing Dracula. That's Dracula. I mean unless you're a Twilight fan, then maybe you're picturing Robert Pattinson's fine self. But no, chances are you're picturing the title character from Bram Stoker's 1897 novel “Dracula” about a vampire named Count Dracula who moves from Transylvania to England in search of new victims of his undead curse. This character, who basically invented the genre of vampires in fiction, was loosely based on, at least named after, a 15th century Romanian prince named Vlad III AKA Vlad the Impaler AKA Vlad Dracula. But did you know, besides the name and the fact that they were both savage, blood-thirsty killers, Vlad Dracula and Count Dracula don't really have all that much in common? Let's fix that. Sources: National Geographic "Vlad the Impaler's thirst for blood was an inspiration for Count Dracula" by Juan Jose Sanchez ArreseigorArs Technica "Scientists find evidence that Vlad the Impaler shed bloody tears" by Jennifer OueletteACS Publications "Count Dracula Resurrected: Proteomic Analysis of Vlad III the Impaler's Documents by EVA Technology and Mass Spectrometry"Time Magazine "Bram Stoker Claimed that Parts of Dracula Were Real. Here's What We Know About the Story Behind the Novel" nosweatshakespeare.com "Dracula: An Overview"Encyclopedia Britannica "Ottoman Empire"Oregon State University Libraries "The Gutenberg Press"Support the show! Buy Me a CoffeeVenmo @Shea-LaFountaine

DMPK Insights
DMPK Insights #5: Mass Spectrometry Imaging - Past, Present and Future

DMPK Insights

Play Episode Listen Later Sep 21, 2023 30:38


In this podcast, Josephine Bunch, Principal Research Scientist and Co-Director of the National Centre of Excellence in Mass Spectrometry (NiCE-MSI) at NPL,  talks about her work, and in particular her involvement in the Cancer Research UK Grand Challenge Programme.  The episode explores the following:Recent innovations in MSI Challenges associated with analyzing ever more complex moleculesLabel-free vs labelled imagingHardware and software improvements and how these affect the industryCombining imaging techniques to extract maximum informationExciting developments for the future, including personalized medicine and the innovative technologies that will make this a realitySpeaker:Josephine Bunch, Ph.D. - Principal Research Scientist and Co-Director of the National Centre of Excellence in Mass Spectrometry Imaging (NiCE-MSI) at NPLJosephine completed a Ph.D. in mass spectrometry imaging at Sheffield Hallam University, followed by a post-doc appointment at the University of Sheffield. Josephine then led a research group at the University of Birmingham, where she also lectured in Chemistry and Imaging. Josephine is currently based at the National Physics Laboratory where she is Co-Director of the National Centre of Excellence in Mass Spectrometry Imaging (NiCE-MSI) and is also Chair of Biomolecular Mass Spectrometry at Imperial College London.  She is currently leading the Cancer Research UK Grand Challenge programme – a fascinating project that aims to deliver new insights into cancer and cancer treatments using the latest mass spectrometry imaging techniques. Stay tuned for more podcasts in our Pharmaron DMPK Insights Series!

The Drug Discovery World Podcast
How is mass spectrometry advancing drug discovery?

The Drug Discovery World Podcast

Play Episode Listen Later Sep 7, 2023 30:36


Today's episode is titled, “How is mass spectrometry advancing drug discovery?", which covers two articles written for Volume 23, Issue 3 – Summer 2022 of DDW. They are called “Native mass spectrometry: Drug discovery's new kid on the block”, and “Addressing the developability gap in pharma”. In the first article, you will hear from Id-leer Liko, klee-tos Sokratous & Miguel Silva at OMass Therapeutics. In the second article, you will hear from Susan Darling, Senior Director, CE and Biopharma, SCIEX and Todd Stawicki, Senior Global Marketing Manager, Biopharma, SCIEX.

Spectrum | Deutsche Welle
Tears of blood & the real-life Dracula

Spectrum | Deutsche Welle

Play Episode Listen Later Aug 26, 2023 16:21


Do you wear Crocs? Because that's the material Italian researchers used to see if the Prince of Walachia (aka 'Vlad the Impaler') was plagued by a rare condition called hemolacria.

JALM Talk Podcast
Pediatric Reference Value Profiling of Essential Trace and Toxic Elements in Healthy Children and Adolescents Using High-Resolution and Triple Quadrupole Inductively Coupled Plasma Mass Spectrometry

JALM Talk Podcast

Play Episode Listen Later Jun 30, 2023 13:54


Clinical Chemistry Podcast
Tissue Mass Spectrometry: How Solid Is Our Future?

Clinical Chemistry Podcast

Play Episode Listen Later Jun 28, 2023 16:01


People Behind the Science Podcast - Stories from Scientists about Science, Life, Research, and Science Careers
708: Tales of Ion Detection: The Making of a Mass Spectrometry Mastermind - Dr. Charles Hohenberg

People Behind the Science Podcast - Stories from Scientists about Science, Life, Research, and Science Careers

Play Episode Listen Later May 15, 2023 44:23


Dr. Charles Hohenberg is a Professor of Physics at Washington University in St. Louis. In the lab, Charles does mass spectrometry of noble gases like Krypton and Xenon. He designed and built his own mass spectrometer which is one of the best in the world. With this instrument, Charles measures noble gas isotope ratios in various sources. A major focus is studying meteorite samples to understand early solar system processes. Charles has always been a tinkerer, and he often spends his free time working on various projects around the house. For example, one of Charles' hobbies is woodworking. He built his own kitchen table and several other pieces of furniture. He received his PhD in Physics from the University of California, Berkeley and has been on the faculty at Washington University since 1970. Charles has received many awards and honors during his career, including election as Fellow of the Meteoritical Society and a Fellow of the St. Louis Academy of Science. He has been awarded the NASA Principal Investigators Award, the NASA Exceptional Achievement Award, and recently the James B. Eads Award honoring engineering or technology from the St. Louis Academy of Science. Charles is here with us today to tell us all about his journey through life and science.

Clinical Chemistry Podcast
Multiplexing Homocysteine into First-Tier Newborn Screening Mass Spectrometry Assays Using Selective Thiol Derivatization

Clinical Chemistry Podcast

Play Episode Listen Later May 5, 2023 8:17


The Drug Discovery World Podcast
Mass spectrometry and CRISPR are pillars of drug discovery

The Drug Discovery World Podcast

Play Episode Listen Later Mar 16, 2023 31:38


This is the latest episode of the free DDW podcast, “Mass spectrometry and CRISPR are pillars of drug discovery”. It covers two articles written for Volume 23, Issue 1 – Winter 2021/22 of DDW. They are called “How ASMS offers more than seeing what sticks” and “CRISPR screening in the third dimension”. In the first article, Dr. Zack Gurard-Levin, Chief Scientific Officer at SAMDI Tech, breaks down three critical components to consider to ensure a successful affinity selection mass spectrometry (ASMS) drug discovery programme. In the second article, Rosie Bryan & Carlos le Sage from Horizon Discovery, explain how CRISPR-Cas9 technology has become a gold standard for functional genomics. You can also find The Drug Discovery World Podcast on Spotify, Google Play and Apple Podcasts.      

Altasciences
Issue 30 — The Evolution and Advancement of LCMS in Drug Development

Altasciences

Play Episode Listen Later Feb 13, 2023 36:42


In this issue, we describe the numerous benefits of incorporating a stable isotope labelled internal standard for quantitative liquid chromatography-mass spectrometry, and detail recent advances in MS technology. Several case studies are presented, which exemplify novel bioanalytical workflows that are required to meet the challenges faced in both non-clinical and clinical development, across a variety of drug classes. - 0:42 Introduction - 5:33 The Case for Stable Isotope Labelled Internal Standards for LCMS Quantitation - 8:34 Recent Innovations in Mass Spectrometry - 15:38 Case Study: Dried Blood Microsampling - 17:14 Case Study: Anti-Epileptic Drug Panel - 19:17 Case Study: COVID-19 Neutralizing Monoclonal Antibody - 21:16 Case Study: Differential Mobility Spectrometry (DMS) - 23:49 Case Study: Bioequivalence - 26:22 Case Study: Oligonucleotides - 33:57 Conclusion Click here to download a readable, PDF version of Issue 13: https://www.altasciences.com/sites/default/files/2022-12/The-Altascientist-issue-30-LCMS.pdf About Altasciences: Altasciences is an integrated drug development solution company offering pharmaceutical and biotechnology companies a proven, flexible approach to preclinical and clinical pharmacology studies, including formulation, manufacturing, and analytical services. For over 25 years, Altasciences has been partnering with sponsors to help support educated, faster, and more complete early drug development decisions. Altasciences' integrated, full-service solutions include preclinical safety testing, clinical pharmacology and proof of concept, bioanalysis, program management, medical writing, biostatistics, clinical monitoring, and data management, all customizable to specific sponsor requirements. Altasciences helps sponsors get better drugs to the people who need them, faster.

New Matter: Inside the Minds of SLAS Scientists
Lab of the Future | Mass Spectrometry Methods in High-Throughput Screening with Maaike Bras

New Matter: Inside the Minds of SLAS Scientists

Play Episode Play 27 sec Highlight Listen Later Jan 30, 2023 19:58 Transcription Available


In continuing our Lab of the Future series, we're joined by Maaike Bras, scientist assay development (Pivot Park Screening Centre), for a detailed discussion on the applications of mass spectrometry methods in high-throughput screening. For a transcript of this episode, please visit this episode's page on Buzzsprout.Key Learning Points: How mass spectrometry can be used for high-throughput screeningHow deep learning and other data mining/analysis methods are improving mass spectrometry What mass spectrometry advancements are being made to enhance the lab of the future Mass spectrometry advantages for affinity-based assays compared to other assays methodsNew from SLAS - the Lab of the Future Short Course on Demand!SLAS has recently launched Lab of the Future, a new short course on demand offering to educate new laboratory technologies and applications to make any laboratory more advanced!To learn more about the Lab of the Future short course including availability, pricing and the instructors, visit:https://www.slas.org/education/slas-short-courses/lab-of-the-future/Stay connected with SLASOnline at www.slas.orgFacebookTwitter @SLAS_OrgLinkedInInstagram @slas_orgYouTubeAbout SLASSLAS (Society for Laboratory Automation and Screening) is an international professional society of academic, industry and government life sciences researchers and the developers and providers of laboratory automation technology. The SLAS mission is to bring together researchers in academia, industry and government to advance life sciences discovery and technology via education, knowledge exchange and global community building.  For more information about SLAS, visit www.slas.org.SLAS publishes two peer-reviewed and MEDLINE-indexed scientific journals, SLAS Discovery and SLAS Technology.Upcoming SLAS Events: SLAS 2023 Microscales Innovation in Life Sciences Symposium September 14-15, 2023 La Jolla, CA, USA SLAS 2023 Sample Management Symposium October 12-13, 2023 Washington, D.C., USA SLAS 2023 Data Sciences and AI Symposium November 14-15, 2023 Basel, Switzerland SLAS2024 International Conference and Exhibition February 3-7, 2024 Boston, MA, USA

Clinical Chemistry Podcast
Neutral-Coating Capillary Electrophoresis Coupled with High-Resolution Mass Spectrometry for Top-Down Identification of Hemoglobin Variants

Clinical Chemistry Podcast

Play Episode Listen Later Jan 13, 2023 11:52


The Anti-Doping Podcast
90 - Investigating Ion Mobility-Mass Spectrometry for Anti-Doping - Chris Chouinard, PhD

The Anti-Doping Podcast

Play Episode Listen Later Nov 15, 2022 36:17


Dr. Chris Chouinard is an Assistant Professor in the Department of Chemistry at Clemson University. In this episode, we discuss Chris's career, his PCC-funded research investigating the development and potential applications of ion mobility-mass spectrometry for anti-doping, and how his work may impact anti-doping and other fields.

Clinical Chemistry Podcast
Identifying Clinically Relevant Bacteria Directly from Culture and Clinical Samples with a Handheld Mass Spectrometry Probe

Clinical Chemistry Podcast

Play Episode Listen Later Nov 11, 2022 21:11


People Behind the Science Podcast - Stories from Scientists about Science, Life, Research, and Science Careers
679: Pioneering Advanced Mass Spectrometry for Proteomics and Metabolomics - Dr. Neil Kelleher

People Behind the Science Podcast - Stories from Scientists about Science, Life, Research, and Science Careers

Play Episode Listen Later Oct 24, 2022 39:17


Dr. Neil Kelleher is the Walter and Mary Elizabeth Glass Professor of Chemistry, Molecular Biosciences, and Medicine at Northwestern University. Neil is a protein biochemist. He weighs and analyzes proteins found in the human body, and he develops technology that allows scientists to measure new things. When he's not doing science, Neil likes to play basketball, and he has also been an avid golfer since he was young. He received his B.A. in chemistry from Pacific Lutheran University and his Ph.D. in chemistry from Cornell University. He conducted postdoctoral research at Harvard Medical School before joining the faculty at the University of Illinois in Urbana-Champaign. In 2010, he joined the faculty at Northwestern University. Neil has received numerous awards and honors over the course of his career, including the Biemann Medal of the American Society for Mass Spectrometry, the Presidential Early Career Award in Science and Engineering, the Camille Dreyfus Teacher-Scholar Award, the Cottrell Scholars Award, the Burroughs Wellcome Award in the Pharmacological Sciences, a CAREER award from the National Science Foundation, and others. In addition, he has received the Pittsburgh Conference Achievement Award, the Pfizer Award in Enzyme Chemistry, and the A.F. Findeis Award in Measurement Science from the American Chemical Society, Division of Analytical Chemistry. Neil was also a Becman Fellow, a Sloan Fellow, a Packard Fellow, a Searle Scholar, and a Fulbright Scholar. In our interview, Neil shares more about his life and science.

The Addiction Podcast - Point of No Return
Michael Gray - Fentanyl and the Poisoning of America

The Addiction Podcast - Point of No Return

Play Episode Listen Later Oct 6, 2022 44:22


Michael Gray is the CEO of Actus Analytical, Inc., which develops spectroscopy solutions for public safety compliance, illicit drug detection, agricultural productivity, and other applications. Michael and his wife Nancy founded The Actus Foundation, a 501(c)(3) charitable organization, in 2018. The Actus Foundation advocates for solutions to treating the entirety of the overdose epidemic problem in America, including the largely forgotten constituency of intermittent users. He founded, with partner Ed Kobilis in 2019, the Fentanyl Awareness Coalition - a coalition of tens of thousands of advocates in the US.  Michael is a popular speaker, offering unique analyses and suggestions for creative solutions to a new problem, i.e., an old problem with a recently altered paradigm. Michael walks participants through the murky world of the drug problem clarifying the threat and dispelling myths.    The Actus Foundation also advocates for the mentally ill, striving to deliver the message that mental illness is a disease the entire family suffers, and suffers in isolation; there are no well-worn paths to solutions available to those in chronic states of mental illness. For all our success in medical science – diagnostic practices, treatment/care and patient advocacy – our nation has left behavioral science in the stone age. Our practice of psychiatric care – diagnostic practices, treatment/care and patient advocacy – is the ugly stepchild hidden in the attic as the country proudly displays her medical science wonders to the world.   In addition to advocacy, Mr. Gray is offering his 35 years of professional expertise in the world of scientific instrumentation as another element of his work on behalf of the victims of overdose. As the Interdict Law and other legislative activity considers nascent technological advances in the ability to detect illicit drugs at the street level, Michael adds his professional expertise to that debate. With experience in the areas of Infrared Spectroscopy and Mass Spectrometry, Michael is participating in the development and deployment of portable testing for narcotics, at the field level, as a means of confirming suspected illegal substances and protecting First Responders.

The Smart 7
NASA trials a real life “Armageddon”, Dolphins have Wingmen, The Woman who could Smell Parkinson's Disease and Muse drop an NFT Album…

The Smart 7

Play Episode Listen Later Sep 25, 2022 17:18


The Smart 7 is a daily podcast that gives you everything you need to know in 7 minutes, at 7 am, 7 days a week... With over 10 million downloads and consistently charting, including as No. 1 News Podcast on Spotify, we're a trusted source for people every day. If you're enjoying it, please follow, share, or even post a review, it all helps... Today's episode includes the following guests: Jacob Rees-Mogg - Secretary of State for Business, Energy and Industrial StrategyCharles McAllister - Director of UK Onshore Oil and GasNick Danby - Anti-fracking activistElena Adams - DART Mission System Engineer Joy Milne - Retired nurseProf Perdita Barran - Professor of Mass Spectrometry at the University of ManchesterJames Jopling - Director of Parkinson's UKSunanda Sharma - Scientist on the Perseverance ProjectEmma Chereskin - Marine mammal scientist at The University of BristolJack Peart - Archeology studentWill Guyatt - Technology reporter In Ireland? Why not try our Ireland Edition? Contact us over at Twitter or visit www.thesmart7.com Presented by Jamie East, written by Olivia Davies and produced by Daft Doris. Hosted on Acast. See acast.com/privacy for more information.

The Smart 7 Ireland Edition
NASA trials a real life “Armageddon”, Dolphins have Wingmen, The Woman who could Smell Parkinson's Disease and Muse drop an NFT Album…

The Smart 7 Ireland Edition

Play Episode Listen Later Sep 25, 2022 17:29


The Smart 7 Ireland Edition is the daily news podcast that gives you everything you need to know in 7 minutes, at 7am, 7 days a week… Consistently appearing in Ireland's Daily News charts, we're a trusted source for people every day. If you're enjoying it, please follow, share or even post a review, it all helps… Today's episode includes references to the following guests: Jacob Rees-Mogg - UK Secretary of State for Business, Energy and Industrial StrategyCharles McAllister - Director of UK Onshore Oil and GasNick Danby - Anti-fracking activistElena Adams - DART Mission System Engineer Joy Milne - Retired nurseProf Perdita Barran - Professor of Mass Spectrometry at the University of ManchesterJames Jopling - Director of Parkinson's UKSunanda Sharma - Scientist on the Perseverance ProjectEmma Chereskin - Marine mammal scientist at The University of BristolJack Peart - Archeology studentWill Guyatt - Technology reporter Contact us over at Twitter or visit www.thesmart7.com Presented by Ciara Revins, written by Oliva Davies and Liam Thompson and produced by Daft Doris. Hosted on Acast. See acast.com/privacy for more information.

Foundry UMC
Lord, Do You Not Care? - July 17th, 2022

Foundry UMC

Play Episode Listen Later Jul 18, 2022 28:26


Lord, Do You Not Care? A guest sermon preached by Stacey Cole Wilson at Foundry UMC July 10th, 2022. “Living The Questions” series.         Text: LUKE 10:38-42 Stacey Cole Wilson is the Executive Minister of Beloved Community for the Baltimore-Washington Conference of The United Methodist Church. She is a wife, mother, ordained minister, igniter of social change, and a champion for human rights. She received a call into ministry as a youth and is a believer that the greatest gift of God is unconditional love. Before joining the Conference Staff, Dr. Wilson served as the Lead Pastor of Good Hope Union UMC in Silver Spring, MD (2012-2016), the Pastor of Mount Winans United Methodist Church in Baltimore (2007- 2012), and as the Associate Pastor of Linthicum Heights United Methodist Church in Linthicum, Maryland (2003-2007). As a writer and minister, she has received national acclaim for her prayers and litanies published in the award-winning Africana Worship Book; and, she has been honored to receive and share the Word of God nationally and internationally for the glory of God and upbuilding of the nations. She has served as Wesley Theological Seminary's Commencement Preacher/Speaker at the National Cathedral in Washington, D.C., Princeton University Chapel's Guest Preacher for their Rev. Dr. Martin Luther King, Jr. Service of Recommitment, and United Theological Seminary's Distinguished Doctoral Alum of the Year. As an ardent believer in education and community service, Dr. Wilson serves on the Board of Governors for Wesley Theological Seminary, is an executive member of the Northeastern Jurisdiction United Methodist Volunteers in Mission (NEJUMVIM), is a member of the International Coaching Federation (ICF) and is a founding member and chaplain of the Female Clergy Support Group of Maryland among many other committees, boards and agencies. Stacey earned her undergraduate degree in Chemistry from Morgan State University and has worked professionally as a Senior Analytical Chemist specializing in Petroleum and Materials Characterization via Mass Spectrometry, X-Ray Fluorescence (XRF), and X-Ray Diffraction (XRD). She has earned a Master of Divinity degree from Wesley Theological Seminary and a Doctor of Ministry degree from the United Theological Seminary with an emphasis on Collaborative Community-Church Partnerships. She is a distinguished Foundations of Church Leadership Duke Divinity Fellow, Lewis Fellow, Lewis Community Leaders Fellow, Transition in Ministry (TiM) Excellence Fellow, and was a participant in The Joseph Engle Preaching Roundtable (3 Yr. Program) at Princeton Theological Seminary in NJ. She is the daughter of Gary and Pearl Cole; wife of International Music Producer and Pastor Wayne Wilson; and, mother of two great joys in her life, Ava, and Christian Wilson. https://foundryumc.org/archive

New Matter: Inside the Minds of SLAS Scientists
The State of What Is - A Lesson in Mass Spectrometry with Michelle Dubuke, Ph.D.

New Matter: Inside the Minds of SLAS Scientists

Play Episode Listen Later Jul 18, 2022 30:15


We're joined by Mass Spectrometry (Mass Spec) expert, Michelle Dubuke, Ph.D.,  to learn all about mass spec! From learning the practical applications of mass spec to how researchers are using the tool to discover new insight into biological aging and cancer development, Dubuke breaks it all down to showcase how expansive mass spec is.About Michelle Dubuke:Michelle Dubuke is currently the Manager, Field Application Scientist at Seer. Dubuke is a mass spectrometrist and protein biochemist focused on translational Precision Medicine workflows. Her previous experience was in varied areas of mass spectrometry, including small molecule LC-MS/MS, targeted and untargeted proteomics, DESI imaging, and intact protein analysis in an academic core facility. She has an established publication record in protein biochemistry, bottom-up proteomics, and targeted metabolomics. About SLAS:SLAS (Society for Laboratory Automation and Screening) is an international professional society of academic, industry and government life sciences researchers and the developers and providers of laboratory automation technology. The SLAS mission is to bring together researchers in academia, industry and government to advance life sciences discovery and technology via education, knowledge exchange and global community building.  For more information about SLAS, visit www.slas.org.SLAS publishes two peer-reviewed and MEDLINE-indexed scientific journals, SLAS Discovery and SLAS Technology. For more information about SLAS and its journals, visit www.slas.org/publications.Registration is now open for the 2022 AI Data Pipelines for Life Sciences Symposium in Seattle, WA, September 26-27.This two-day symposium will allow participants to explore how AI data pipelines are integrated into the life sciences. Attendees will learn about MLOPS, applications, techniques, and architectures of data and their uses in the life sciences. The SLAS 2022 Bio Entrepreneurship Symposium will allow emerging bio entrepreneurs, start-up companies, academics and those considering bio-entrepreneurship to explore the start-up ecosystem. Register by visiting: https://www.slas.org/events-calendar/slas-2022-bio-entrepreneurship-symposium/attend/register/

COMPLEXITY
Sara Walker on The Physics of Life and Planet-Scale Intelligence

COMPLEXITY

Play Episode Listen Later Jul 2, 2022 82:23 Very Popular


What is life, and where does it come from? These are two of the deepest, most vexing, and persistent questions in science, and their enduring mystery and allure is complicated by the fact that scientists approach them from a myriad of different angles, hard to reconcile. Whatever else one might identify as universal features of all living systems, most scholars would agree life is a physical phenomenon unfolding in time. And yet current physics is notorious for its inadequacy with respect to time. Life appears to hinge on information transfer — but, again, what do we mean by “information,” and what it is relationship to energy and matter? If humankind can't settle fundamental issues with these theoretical investigations, we might be missing other kinds of life (and mind) — not just in outer space, but here on Earth, right beneath our noses. But new models that suggest a vastly wider definition of life offer hope that we might — soon! — not only learn to recognize the biospheres and technospheres of other living worlds, but notice other “aliens” at home, and even find our place amidst a living cosmos.Welcome to COMPLEXITY, the official podcast of the Santa Fe Institute. I'm your host, Michael Garfield, and every other week we'll bring you with us for far-ranging conversations with our worldwide network of rigorous researchers developing new frameworks to explain the deepest mysteries of the universe.This week on the show, we speak with SFI External Professor Sara Walker (Twitter, Google Scholar), Deputy Director of The Beyond Center at ASU, where she acts as Associate Professor in half a dozen different programs. In this conversation, we discuss her pioneering research in the origins of life and the profound and diverse implications of Assembly Theory — a new kind of physics she's developing with chemist Leroy Cronin and a team of SFI and NASA scholars.  Sara likes to speculate out loud in public conversation, so strap in for an unusually enthusiastic, animated, and free-roaming conversation at the very bleeding edge of science. And be sure to check out our extensive show notes with links to all our references at complexity.simplecast.com.If you value our research and communication efforts, please subscribe, rate and review us at Apple Podcasts or Spotify, and consider making a donation — or finding other ways to engage with us — at santafe.edu/engage.Thank you for listening!Join our Facebook discussion group to meet like minds and talk about each episode.Podcast theme music by Mitch Mignano.Follow us on social media:Twitter • YouTube • Facebook • Instagram • LinkedInMentioned Papers:Intelligence as a planetary scale processby Adam Frank, David Grinspoon & Sara WalkerThe Algorithmic Origins of Lifeby Sara Imari Walker & Paul C. W. DaviesBeyond prebiotic chemistry: What dynamic network properties allow the emergence of life?by Leroy Cronin & Sara WalkerIdentifying molecules as biosignatures with assembly theory and mass spectrometryby Stuart Marshall, Cole Mathis, Emma Carrick, Graham Keenan, Geoffrey Cooper, Heather Graham, Matthew Craven, Piotr Gromski, Douglas Moore, Sara Walker & Leroy CroninAssembly Theory Explains and Quantifies the Emergence of Selection and Evolutionby Abhishek Sharma, Dániel Czégel, Michael Lachmann, Christopher Kempes, Sara Walker, Leroy CroninQuantum Non-Barking Dogsby Sara Imari Walker, Paul C. W. Davies, Prasant Samantray, Yakir AharonovThe Multiple Paths to Multiple Lifeby Christopher P. Kempes & David C. Krakauer Other Related Videos & Writing:SFI Seminar - Why Black Holes Eat Informationby Vijay BalasubramanianMajor Transitions in Planetary Evolutionby Hikaru Furukawa and Sara Imari Walker2022 Community Lecture: “Recognizing The Alien in Us”by Sara WalkerSara Walker and Lee Cronin: The Alien Debateon The Lex Fridman ShowIf Cancer Were Easy, Every Cell Would Do ItSFI Press Release on work by Michael LachmannThe Ministry for The Futureby Kim Stanley RobinsonRe: Wheeler's delayed choice experimentWikipediaOn the SFI “Exploring Life's Origins” Research ProjectComplexity Explorer's Origins of Life Free Open Online CourseChiara Marletto on Constructor TheorySimon Saunders, Philosopher of Physics at OxfordRelated SFI Podcast Episodes:Complexity 2 - The Origins of Life: David Krakauer, Sarah Maurer, and Chris Kempes at InterPlanetary Festival 2019Complexity 8 - Olivia Judson on Major Energy Transitions in Evolutionary HistoryComplexity 17 - Chris Kempes on The Physical Constraints on Life & EvolutionComplexity 40 - The Information Theory of Biology & Origins of Life with Sara Imari Walker (Big Biology Podcast Crossover)Complexity 41 - Natalie Grefenstette on Agnostic Biosignature DetectionComplexity 68 - W. Brian Arthur on Economics in Nouns & Verbs (Part 1)Complexity 80 - Mingzhen Lu on The Evolution of Root Systems & Biogeochemical CyclingAlien Crash Site 015 - Cole MathisAlien Crash Site 019 - Heather GrahamAlien Crash Site 020 - Chris KempesAlien Crash Site 021 - Natalie Grefenstette

Outliving Cancer
The Metabolic Basis of Disease

Outliving Cancer

Play Episode Listen Later May 17, 2022 17:10


Today on Outliving Cancer, Dr. Nagourney introduces colleague and research collaborator Dr. Paulo D'Amora on using quantitative Mass Spectrometry in identifying metabolic signatures to determine a predisposition to disease.    

The Rabbit Hole
#26 - Chemist & Mass Spectrometry Expert Dr. Guido Verbeck

The Rabbit Hole

Play Episode Listen Later Mar 22, 2022 154:02


Dr. Guido F. Verbeck, Professor of Chemistry and Biochemistry at the University of North Texas, is an expert is mass spectrometry, specifically instrument design and development. Dr. Verbeck was a Proctor & Gamble Fellow at Texas A&M University, and Postdoctoral fellow at Oak Ridge National Laboratory. He has developed mass spectrometers over the past 20 years, and has been a member of the analytical community for 25 years. In this, he has developed many stand-off chemical detectors, and performed field work for the analysis of biomarkers (breast cancer, respiratory distress), airborne chemical weapons (Dugway S/K Challenge), and illicit drugs. - Connect with Dr. Guido and Nathan via: https://rabbit.is/26/ --- Send in a voice message: https://anchor.fm/2052/message

BTBA presents: 生技來一刻
Faculty as Entrepreneurs II 學者創業專訪 II – Empowering Clinical Diagnostics with Mass Spectrometry質譜儀上的洞燭先機ft. Dr. Cheng-Chih Richard Hsu徐丞志博士

BTBA presents: 生技來一刻

Play Episode Listen Later Mar 16, 2022 50:53


BTBA Podcast 生技來一刻「Faculty as Entrepreneurs-學者創業訪談」系列旨在將生技產業概述的格局放大到由學術研究、藥廠及生技公司串連起的整個生態系,讓我們可以從多面向角度來了解整個生醫製藥、生物技術產業;藉由連線訪談橫跨學術及業界領域的專家來了解基礎醫學研究與臨床應用的連結整合,破除一些學術界與新創產業的迷思,希望能幫助更多學術期刊上的重要研究找到一條實際應用的產業出路。 學者創業訪談系列第二集,把焦點拉回台灣的學術及生醫產業環境生態,邀請到目前在國立台灣大學化學系擔任副教授的徐丞志博士(Dr. Cheng-Chih Richard Hsu)一起來探討分享,他是如何將他實驗室的質譜鑑定及分析化學的技術應用到醫療檢測上,「將學術界的研究成果轉譯到臨床上的實際應用」這樣子的新興觀念在實際操作層面上,目前台灣的環境有哪些因素要考量、及有哪些問題需要一步步的解決。 Time Stamps: 講者求學、職涯經驗分享 (3:37) 回台展開教授職涯後面臨的挑戰 (6:30) 學術研究領域的規劃及創業藍圖的結合 (14:07) 公司草創過程及團隊營運模式 (19:25) 學術人的思維及創業家的視野 (22:42) 團隊合作的重要性 (23:53) 創業家所需要具備的心胸及眼光 (29:10) 台灣學界、業界環境對學者創業的支持及資源 (32:56) 年輕教授的創業規劃 (41:01) Day-to-day life 及十年前、十年後 (42:15) 對全球台灣生技人的勉勵 (45:15)

BioInnovation Spotlight
Quantifying Epigenetic Modifiers with Mass Spectrometry, with Moritz Voelker-Albert of EpiQMAx

BioInnovation Spotlight

Play Episode Listen Later Oct 21, 2021 12:31


Epigenetics is the study of the changes that occur on top of the DNA without changing the genome sequence. These still affect the expression of our genes, and thereby shape our phenotype. Like the genome, epigenetic traits can be inherited. But unlike the genes, epigenetic traits are flexible and can be lost or regained and are influenced by our lifestyle. This makes them a tantalizing pharmaceutical target. EpiQMAx is a spin-out from https://www.lmu.de/en/ (LMU University) based on an idea from Prof. Axel Imhof, Dr. Moritz Voelker-Albert and Dr. Victor Solis who have worked in the Histone Modifications group at the https://www.en.bmc.med.uni-muenchen.de/index.html (BioMedical Center in Munich). Backed up by their knowledge and experience on mass spectrometry and epigenetic modifications, their goal is to contribute to the development of epigenetic drugs, together with the pharmaceutical industry. In this episode of BioInnovation Spotlight, we talk to Moritz Voelker-Albert about how EpiQMAx came about, how epigenetics can be used to inform us on our health, and his future plans for the company.

HardwareX Podcasts
The Journey of HardwareX with co-Editor-in-chief (Todd Duncombe, PhD)

HardwareX Podcasts

Play Episode Listen Later Oct 12, 2021 17:38


In this episode of HardwareX podcasts, we talk to Todd Duncombe who is the co-Editor-in-Chief of HardwareX. Todd is a Postdoctoral researcher at the renowned ETH Zurich, Department of BioSystems Science and Engineering in Basel, Switzerland. He has published several impactful papers and inventions on Droplet Microfluidic, Analytical Chemistry, Mass Spectrometry, MEMS, and Electrokinetic Transport. He developed assays to streamline biomanufacturing pathways and combinatorial screening, often improvising the techniques in mass spectrometry and electrophoresis. Todd also has been an active member of Tekla Labs. This episode was recorded, edited, and produced by Santosh Pandey from Iowa State University. The music is provided by Lesfm from Pixabay (Title: Uplifting Corporate and Inspiring (IG version 60s)).

Test Tubes and Cauldrons
Episode 24: The Poison Path

Test Tubes and Cauldrons

Play Episode Listen Later Sep 3, 2021 52:35


Poisons are a natural wonder and phenomena, one that should be handled with care, but have so much use within and outside of the occult. Yet, as with many things falling under the umbrella of left hand path, it is often demonized, seen as dark, ill-willed, and incapable of doing good. Join the hosts today as we discuss what the poison path is, misconceptions surrounding it, and how it actually requires having a hand in the benevolent and baneful realms.Come discuss in our Discord! https://discord.gg/kJthJyxTBcResources:Articles and Papers:Poison as medicine: https://www.amnh.org/explore/news-blogs/on-exhibit-posts/the-power-of-poison-poison-as-medicineAnimal Toxins and Therapeutic Treatment for Neurological Disease: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829052/A Constructive Approach on Lethal Plants for Medicine: https://toxicology.imedpub.com/a-constructive-approach-on-lethal-plants-formedicinal-use.php?aid=23639Books:The Witches' Ointment by Thomas HatsisThe Poison Trials by Alisha RankinViridarium Umbris: the pleasure garden of shadow & Veneficium: Magic by Daniel SchulkeWitchcraft and the Poison Path by Daniel Schulke.Pharmakognosis trilogy by Dale PendellWant to learn more about separations? See the links below!Introduction to Chromatography: https://chem.libretexts.org/Courses/ProvidenceCollege/CHM331AdvancedAnalyticalChemistry1/11%3AAnIntroductiontoChromatographic_SeparationsIntroduction to Mass Spectrometry: https://chem.libretexts.org/Courses/Purdue/Purdue%3A_Chem_26200%3A_Organic_Chemistry_II_(Wenthold)/Chapter_11%3A__IR_and_Mass_Spectrometry/11.06%3A_Introduction_to_Mass_SpectrometryMass Spec applications in biological research: https://iubmb.onlinelibrary.wiley.com/doi/full/10.1002/bmb.2004.494032020331

Alien Crash Site
What to look for, when we don't know what we're looking for? #019 with Heather Graham

Alien Crash Site

Play Episode Listen Later Sep 3, 2021 54:28


Learn more about everything referenced in this episode by clicking the links below:Identifying Molecules as Biosignatures with Assembly Theory and Mass Spectrometry.Generalized Stoichiometry and Biogeochemistry for Astrobiological Applications.Time TeamElemental CyclesDNA has Four Bases. Some Viruses Swap in a FifthBennuHayabusa MissionAlien Crash Site Episode 015, with Cole Mathis on Assembly Theory.Determination of AzimuthAtlantis Dispatch 001, in which we contemplate the meaning of “past” life.Viking missions84001IsuaBob Hazen

Renata Newborn Screening Podcast
Was mass spectrometry the right technique to screen large populations?

Renata Newborn Screening Podcast

Play Episode Listen Later Jun 17, 2021 32:04


No one really knew whether mass spectrometry was up to the task of population screening. Could the instruments cope with the tens-of-thousands of dried blood spots that needed to be analyzed every year? In the mid 1990s, Dr. Mike Morris began working with newborn screening labs around the world to try and answer these questions.

Renata Newborn Screening Podcast
The application of tandem mass spectrometry to NBS for amino acids and acylcarnitines - An interview with David Millington

Renata Newborn Screening Podcast

Play Episode Listen Later Apr 22, 2021 28:10


For the 30 years following Dr. Robert Guthrie's invention of a PKU screening test newborn screening tests were limited in number. That all changed when biochemists at Duke University first applied tandem mass spectrometry to solve a puzzling clinical case. The result changed the way the newborn screening community thought about adding new screening tests.

Cell Culture Dish Podcast
Optimizing Protein Expression and Purification using Mass Spectrometry Analysis

Cell Culture Dish Podcast

Play Episode Listen Later Dec 17, 2020 31:24


In this podcast, we conducted a panel discussion with experts from Peak Proteins on common protein challenges and the use of mass spec to overcome expression and purification issues. We also discussed how mass spec can also be utilized in working with complex proteins and in-process modifications.