Podcasts about lipids

A substance of biological origin that is soluble in nonpolar solvents

  • 648PODCASTS
  • 1,332EPISODES
  • 37mAVG DURATION
  • 5WEEKLY NEW EPISODES
  • May 27, 2025LATEST
lipids

POPULARITY

20172018201920202021202220232024

Categories



Best podcasts about lipids

Show all podcasts related to lipids

Latest podcast episodes about lipids

JACC Podcast
Insights From the INTERASPIRE Study | JACC Deep Dive

JACC Podcast

Play Episode Listen Later May 27, 2025 10:56


JACC focuses in again on Lipids in our June 3 issue, bringing critical insights into emerging targeted therapies. In the June 3 Deep Dive, editor-in-chief Harlan M. Krumholz, MD, SM, FACC, reviews the INTERASPIRE study by Ray et al, reviewing implications, key findings, and a thoughtful summary and analysis of the reviewer findings.

Boundless Body Radio
Clarifying the KETO-CTA Study with Dr. Adrian Soto-Mota, PhD!

Boundless Body Radio

Play Episode Listen Later May 21, 2025 67:02


Send us a textDr. Adrian Soto-Mota is a returning guest on our show! Be sure to check out episode 138 of Boundles Body Radio, which was part of a special series we did, featuring Dr. Nick Norwitz as the guest host!We also hosted Dr. Soto-Mota on episode 340, episode 419, and episode 599 of our show!Dr. Soto-Mota is a MD PhD & Specialist in Internal Medicine and Data Science researcher at the Unidad de Investigación de Emfermedades Metabólicas! Dr. Soto-Mota is passionate about studying low carbohydrate and ketogenic diets, and how they impact human metabolism.Dr. Soto-Mota earned his MD from the Universidad Nacional Autónoma de México, and earned his Ph.D. at Oxford. He has created many resources to help people successfully implement a low carbohydrate diet, and provides that help for both English and Spanish speaking individuals.He is the co-author of a 2022 paper titled The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets, and the co-author of the recent paper titled Plaque Begets Plaque, ApoB Does Not: Longitudinal Data From the KETO-CTA Trial- JACC Journal April 7, 2025, both of which were also co-authored by former guests Dr. Norwitz and Dave Feldman, who we hosted in episode 109 of Boundless Body Radio!Find Dr. Soto-Mota at-TW- @AdrianSotoMotaPlaque Begets Plaque, ApoB Does Not: Longitudinal Data From the KETO-CTA Trial- JACC Journal April 7, 2025Keto Cholesterol study SHOCKS scientific community | LMHRs & heart disease from the Nutrition Made Simple YouTube ChannelAnalyzing the KETO-CTA Study with Dr. Gil Carvalho 813 on Boundless Body Radio!Discussing Keto-CTA with Darius Sharpe with Dave Feldman and Darius SharpeFind Boundless Body at- myboundlessbody.com Book a session with us here!

Plant Based Eating Made Easy | Simple Strategies & Clear Nutrition Guidance to Transform Your Health | Dietitian, Plant Based
104 | Can Vegan and Plant-Based Diets Lower Cholesterol and LDL Lipid Levels?

Plant Based Eating Made Easy | Simple Strategies & Clear Nutrition Guidance to Transform Your Health | Dietitian, Plant Based

Play Episode Listen Later May 13, 2025 9:41 Transcription Available


Are you really wanting to improve your heart health, but feel lost on what to do? All you know is that you've been warned by your doctor to ‘change your diet'. But which one and how? There seem to be so many different ones out there, that it's confusing and overwhelming. So can a vegan diet or a plant-based one really help drop blood lipids, lower your risk of a heart attack and give you more time with loved ones?   Let's find out on today's podcast. In this episode, we'll see how effective a vegan or whole food plant-based diet can be and I'll also share the experience of some from my Community. So if you're ready to build better heart health naturally, meet me inside this episode!   Related Episodes: Ep. 90 | Her Cholesterol & Triglycerides Drop Within 3 Weeks & Husband's Diabetes Improves – Interview with Susan [Part 1]: https://www.plantnourished.com/blog/interview-with-susan-part-one   Ep. 91 | Weight Loss and Tips for Staying Plant-Based With a Busy Life - Interview With Susan [Part 2]: https://www.plantnourished.com/blog/91-interview-with-susan-part-two]     Contact -> healthnow@plantnourished.com Learn -> www.plantnourished.com Join -> Plant-Powered Life Transformation Course: www.plantnourished.com/ppltcourse Connect in the Facebook Community -> www.bit.ly/pbdietsuccess Apply -> Free Rapid Health Transformation Call: https://bit.ly/plantnourished Free Resource -> Quick Start Grocery Guide for Plant-Based Essentials: www.plantnourished.com/groceryguide     Have a question about plant-based diets that you would like answered on the Plant Based Eating Made Easy Podcast? Send it by email (healthnow@plantnourished.com) or submit it by a voice message here: www.speakpipe.com/plantnourished     [Plantbased Diet, Plant Based Eating, Cholesterol, Triglycerides, Heart Health, Cardiovascular Health, Heart Attacks, Strokes, How to Eat for Health]

Forever Young Radio Show with America's Natural Doctor Podcast
Episode 602: Ep 602 Muscle Soreness and Pain? Think PEA

Forever Young Radio Show with America's Natural Doctor Podcast

Play Episode Listen Later May 13, 2025 46:34


To help us unpack all the research and studies we have Dr. Stengler joining us today.In addition to authoring 30 books on health and several best-sellers such as “The Natural Physician's Healing Therapies,” “Prescription for Natural Cures,” “Prescription for Drug Alternatives,” and “Outside the Box Cancer Therapies,” Dr. Stengler has been published in several peer-reviewed medical journals such as The International Journal of Family & Community Medicine, Endocrinology & Metabolism International Journal, and Journal of Nutritional Health & Food Engineering.Dr. Stengler's, NMD. The newest book is called, The Holistic Guide to Gut Health. A comprehensive yet accessible approach to healing leaky gut and the many uncomfortable symptoms it causes. Dr Stengler is also the founder of The Stengler Center for Integrative Medicine.Talking Points:Palmitoylethanolamide (PEA), is a naturally occurring fatty acid derivative made in the body and found in small amounts in foods. Several human studies have demonstrated that PEA has broad-spectrum pain-relieving properties, anti-inflammatory effects, and nerve protection.PEA was first discovered in 1957 by scientists at Merck Sharp & Dohme, who isolated it from egg yolk, peanut meal, and soy lecithin. They found that PEA had anti-inflammatory properties in guinea pigs.However, PEA's role as a potential therapeutic agent was not widely recognized until 1993, when Rita Levi-Montalcini and her colleagues published research that suggested PEA has anti-inflammatory properties. Levi-Montalcini's group termed PEA an autocoid local injury antagonist (ALIA), and suggested that it acts locally to counteract injuryMultiple studies have demonstrated that PEA improves all sorts of pain. For example, a 2023 analysis of 11 studies found that PEA improved pain of various conditions, including muscle and joints, nerves, gynecological, and digestive. In terms of joint pain, a high-quality study demonstrated that PEA significantly reduced adult joint pain compared to placebo. Moreover, 8 clinical trials demonstrated that PEA was effective for low back pain, sciatica, and carpal tunnel syndrome. Even migraine headache pain was shown in published research to be improved with PEA.Lipid mediators help to balance the immune, nervous, and endocrine systems, affecting pain pathways related to inflammation. But unfortunately, due to changing diets, many of us do not get the nutrition and activity we need to make enough PEA ourselves.Supplemental PEA, by Levagen+ is properly formulated for optimal bioavailability, 75% more bioavailable to cell receptors than dietary forms. Levagen+ liposomal delivery of PEA has been clinically studied and shows benefits in joint pain, nerve pain, migraine, infections, sleep, and cognitive function.Learn more about Emerald Labs PEA+ Levagen Use the code: Forever and get 20% off your order. 

Doctor Warrick
EP385: What You Need to Know About Mono and Poly genics in Lipid Management

Doctor Warrick

Play Episode Listen Later May 10, 2025 10:30


Welcome to my podcast. I am Doctor Warrick Bishop, and I want to help you to live as well as possible for as long as possible. I'm a practising cardiologist, best-selling author, keynote speaker, and the creator of The Healthy Heart Network. I have over 20 years as a specialist cardiologist and a private practice of over 10,000 patients. In this podcast, Dr. Warrick Bishop, a cardiologist and CEO of the Healthy Heart Network, discusses the significance of genetics in cholesterol-related health issues. He explains the difference between monogenic and polygenic influences on lipid profiles, with monogenic abnormalities being linked to single genetic mutations that significantly impact cholesterol levels, such as familial hypercholesterolemia. In contrast, polygenic issues involve multiple small genetic variations that collectively affect cholesterol without causing as severe elevations.

CRTonline Podcast
Incremental Prognostic Value Of Calcium Detection On The Lipid-rich Plaque Vulnerability: Development And Validation Of An Artificial Intelligence Algorithm For Coronary Calcium Detection With Clinica

CRTonline Podcast

Play Episode Listen Later May 6, 2025 5:56


Incremental Prognostic Value Of Calcium Detection On The Lipid-rich Plaque Vulnerability: Development And Validation Of An Artificial Intelligence Algorithm For Coronary Calcium Detection With Clinica

The Superhumanize Podcast
Beyond Cholesterol: Dr. Ronald Krauss on Lipids, Inflammation, and the Hidden Codes of Heart Health

The Superhumanize Podcast

Play Episode Listen Later Apr 30, 2025 57:49


Welcome to The Superhumanize Podcast.I'm your host, Ariane Sommer and today, we're not just talking about heart health…We're decoding it.My guest is Dr. Ronald Krauss, one of the most influential voices in cardiovascular research today. A professor of medicine at UCSF and a pioneer in lipidology, Dr. Krauss has reshaped how we understand cholesterol, inflammation, and the subtle particles that move through our blood and, often, determine our fate.In this conversation, we go far beyond the standard cholesterol panel.We explore the deeper nuances like the size and density of LDL particles, the overlooked power of ApoB and Lp(a), and how refined carbohydrates, not saturated fats, may play a much larger role in cardiovascular risk than we've been led to believe.We also enter emerging frontiers:How the gut microbiome shapes the heart, how our genes can guide more precise therapies, and how personalized nutrition may become one of the most powerful tools for prevention in the years to come.This episode is not just for the curious, it's for those who sense there's more to the story of heart disease than numbers on a lab report.It's for those who believe science can be both evidence-based and visionary.And for those of us who know the body carries not just risk, but memory, intelligence, and code.Episode highlights:Why small, dense LDL particles are more dangerous than large onesThe role of ApoB and Lp(a) as underused but powerful heart health indicatorsHow metabolic syndrome and inflammation interconnect with lipid disordersThe surprising truth about saturated fat vs. refined carbsThe promise (and limitations) of personalized nutrition and genomicsHow physical activity and gut health shape lipid metabolismNew frontiers in the fight against dementia linked to cardiovascular functionResources mentioned:Dr. Krauss' Wikipedia page:https://en.wikipedia.org/wiki/Ronald_Krauss_(medical_researcher)Dr. Krauss' professional profiles:https://profiles.ucsf.edu/ronald.krausshttps://amecenter.ucsf.edu/people/ronald-krauss-md

Cholestérol : Et si votre foie était le vrai coupable ? La synthèse du cholestérol démystifiée

Play Episode Listen Later Apr 30, 2025 34:12 Transcription Available


❤️ Bonjour,Bienvenue dans ce nouvel épisode d'En Plein Cœur ! Aujourd'hui, on part à la découverte d'un organe clé dans la production du cholestérol : le foie.

Plant Based Briefing
1047: How Can I Lower My Triglycerides? By Thomas Campbell MD at NutritionStudies.org    

Plant Based Briefing

Play Episode Listen Later Apr 29, 2025 6:17


How Can I Lower My Triglycerides? “Going to the doctor for your fasting lipid panel results can be an exercise in confusion. You will get numbers for your total cholesterol, LDL cholesterol (“unhealthy” cholesterol), HDL cholesterol (“healthy” cholesterol), and triglycerides. Although the major emphasis in treating abnormal lipid panel results focuses on getting LDL cholesterol below a certain level, your doctor might also make recommendations about your HDL and triglycerides.” Listen to today's episode for details, written by Thomas Campbell, MD at NutritionStudies.org  #vegan #plantbased #plantbasedbriefing #lipid #triglycerides #cholesterol #cvd #cardiovasculardisease #lipidpanel   ======================== Original post: https://nutritionstudies.org/lower-triglycerides/  ========================== Related Episodes: 861: Eat Quinoa and Lower Triglycerides? https://plantbasedbriefing.libsyn.com/861-eat-quinoa-and-lower-triglycerides-by-dr-michael-greger-at-nutritionfactsorg  Related Episodes: use search feature at https://www.plantbasedbriefing.com/episodes-search     Search for cholesterol, heart disease ========================= The T. Colin Campbell Center for Nutrition Studies was established to extend the impact of Dr. Campbell's life changing research findings. For decades, T. Colin Campbell, PhD, has been at the forefront of nutrition education and research. He is the coauthor of the bestselling book, The China Study, and his legacy, the China Project, is one of the most comprehensive studies of health and nutrition ever conducted. Their mission is to promote optimal nutrition through science-based education, advocacy, and research. By empowering individuals and health professionals, we aim to improve personal, public, and environmental health. ====================== FOLLOW THE SHOW ON: YouTube: https://www.youtube.com/@plantbasedbriefing     Spotify: https://open.spotify.com/show/2GONW0q2EDJMzqhuwuxdCF?si=2a20c247461d4ad7 Apple Podcasts: https://podcasts.apple.com/us/podcast/plant-based-briefing/id1562925866 Your podcast app of choice: https://pod.link/1562925866 Facebook: https://www.facebook.com/PlantBasedBriefing   LinkedIn: https://www.linkedin.com/company/plant-based-briefing/   Instagram: https://www.instagram.com/plantbasedbriefing/     

Naturally Nourished
Episode 442: Why We Love Grassfed Whey + Announcing Our New Whey Protect!

Naturally Nourished

Play Episode Listen Later Apr 28, 2025 36:45


In this episode, we're talking all things grassfed whey—a supplement we recommend to nearly every client for good reason. From weight loss and lean body mass to metabolic and immune health, the benefits of whey are powerful and broad spectrum. We break down what whey protein is, how it's made, and why we choose to use a whey concentrate over an isolate. We dive into the synergistic compounds found only in whey concentrates that are low heat processed like lactoferrin, CLA, and immunoglobulins—and how they go beyond muscle to support immune resilience, gut lining integrity, and even antioxidant production via glutathione synthesis. We're thrilled to unveil Whey Protect—our upgraded version of Naturally Nourished Grassfed Whey, now with added serum bovine immunoglobulins to further support immunity and reduce inflammation. We touch on how our formula stacks up in purity compared to mainstream brands and discuss the Clean Label Project's recent findings on heavy metals in popular protein powders. Plus, we share our favorite ways to incorporate Whey Protect into your daily routine for optimal health! Also in this episode:  Whey Protect Now Available - use code NN Whey for 15% off!  Episode 288: Whey Protein: lactoferrin, immunoglobulins, BCAAs and more!  Episode 368 What's up with Armra Colostrum? Serum Bovine Immunoglobulins vs. Colostrum What is whey and how is it made?  Comparing whey concentrate to whey isolate Compounds that make whey a superfood Immunoglobulins (IgG, IgA, IgM) – Immune Defense & Gut Health Lactoferrin – Iron-Binding Protein with Antimicrobial Power Glycomacropeptides (GMPs) – Gut & Brain Health Serum Albumin – Antioxidant & Detox Support Growth Factors (IGF-1, TGF-β) – Muscle Growth & Tissue Repair Why are are adding Serum Bovine Immunoglobulins to Whey Protect Gut Health & Leaky Gut Repair Immune System Resilience Detoxification & Inflammation Control Recovery from exercise induced stress Whey and muscle protein synthesis, workout recovery & fat loss Whey Protein Supplementation Enhances Whole Body Protein Metabolism and Performance Recovery after Resistance Exercise: A Double-Blind Crossover Study The Effect of Whey Protein Supplementation on the Temporal Recovery of Muscle Function Following Resistance Training: A Systematic Review and Meta-Analysis Inulin-type fructans and whey protein both modulate appetite but only fructans alter gut microbiota in adults with overweight/obesity: A randomized controlled trial - PubMed Cocoa and Whey Protein Differentially Affect Markers of Lipid and Glucose Metabolism and Satiety Effects of whey protein and resistance exercise on body composition: a meta-analysis of randomized controlled trials  Whey and antioxidant production Whey Protein Supplementation Improves Nutritional Status, Glutathione Levels, and Immune Function in Cancer Patients: A Randomized, Double-Blind Controlled Trial Concerns with heavy metal toxicity & why you don't need to worry about this with Whey Protect!  Lead and cadmium found in muscle-building protein powders, report says | CNN 2024-25 Protein Powder Category Report How to use Whey Protect Banana Bolt Smoothie Matcha Green Smoothie Cinnamon Almond Keto Shake Cherry Vanilla Nirvana Smoothie How to Make a Keto Protein Shake and The Importance of Protein Easy Keto Green Smoothie (with super foods!) What makes Whey Protect Superior? Grass-fed, low-heat whey concentrate → Preserves bioactive compounds Contains ImmunoLin® serum bovine immunoglobulins → Supports immunity & gut health Rich in cysteine & glutathione → Powerful antioxidant support Boosts muscle growth & recovery → High leucine for optimal muscle synthesis Clean, third-party tested → No heavy metals or contaminants Sponsors for this episode:  Whey Protect: introducing our new Grassfed Whey with added serum bovine immunoglobulins to meet your protein goals and protect the body against infection, toxins, and regulate inflammatory response!   We saw the demands with sales increase of our GI Immune Builder and wanted to incorporate the therapeutic benefits of immunoglobulins in a daily easy to use product that can be used for enhanced immune function, metabolic results, and gut health.   Our Grassfed Whey has always been a top selling product in the Naturally Nourished line due to our quality sourcing and low heat processing to retain antioxidants and beneficial immune compounds such as lactoferrin and immunoglobulins. We wanted to ensure when you take our whey that you are providing your body with a shield of defense against pathogens (bacteria, virus, parasites, mold), toxins, and oxidative stress. Meet Whey Protect, our reformulated and enhanced Naturally Nourished Grassfed Whey.   We've added 350mg serum bovine immunoglobulins to each scoop to ensure you and your family receive a clinical impact to Protect you while helping you reach your daily protein goals with ease.    You're just a scoop a-WHEY from: Muscle gains  Immune resilience Improved bone density Gut health Lower toxicity Enhanced antioxidant status Reduced inflammation Weight loss with satiety and appetite regulation   Added Value at no added cost! We are thrilled to offer you this amazing upgrade at the same price, plus save during our launch sale! Use the code NNWHEY for 15% off    This episode is sponsored by Wild Foods, a company that puts quality, sustainability, and health first in all of their products. They have everything from coffee to turmeric to medicinal mushrooms, and every single product is painstakingly sourced from small farms around the globe. They take their mission seriously to fix the broken food system, and believe real food is medicine. They've partnered with us to give you guys an exclusive discount, so use the code ALIMILLERRD for 12% off your order at WildFoods.co! 

Biohacking Superhuman Performance
#329: How C60 Is Changing Aging: Energy, Brain Health, and Recovery Insights With Ian Mitchell

Biohacking Superhuman Performance

Play Episode Listen Later Apr 25, 2025 73:50


In this episode, we're going deep on Carbon 60—also known as C60 or buckyballs. If you've ever wondered how a molecule that started life as an industrial lubricant ended up a star player in the world of anti-aging, you're in for a treat. Ian and I talk about the original studies that blew everyone's minds (including a rat study where the animals lived nearly twice as long as expected!), and we discuss Ian's own hands-on research, from mouse models to dogs, horses, and even human applications.   What we discuss: C60 explained: origins, “buckyballs,” and research ... 00:08 C60 rat and mouse longevity studies ... 00:09 Lipid binding & targeted delivery ... 00:16 C60: antioxidant, adaptogen, mitochondrial effects ... 00:18 Athlete case study & performance benefits ... 00:25 Applications for fatigue, brain fog, metabolic issues ... 00:32 Autoimmune/inflammatory benefits & mitochondrial origins ... 00:34 Hair, scalp, and ovarian health ... 00:38 Neurodegeneration, glymphatics & brain serums ... 00:45 Optimizing cognition & cycling C60 ... 00:51 Safety notes: who should avoid and why ... 00:53 Product lineup & new developments ... 01:01 What to look for in C60 products ... 01:09   Our Amazing Sponsors: LVLUP - Neuro Re-Generate the world's first liposomal triple peptide formula, designed to support mental clarity, focus, and overall brain health. Visit www.lvluphealth.com and use code NAT10 for 10% off your order.   Peptide Pro App - When you're working with multiple peptides, timing and precision matter. From smart scheduling to real-time dose checklists, it keeps things organized and on track. Receive 50% off for the first month. Visit www.peptidepro.app to download the app and use code NATHALIE50 to get started today.   Wizard Sciences (Neural Rx) - designed to protect your brain long-term. With C60 (an antioxidant) and anti-inflammatory benefits, it combats oxidative stress and helps keep those brain cells healthy and happy. Plus, it supports mitochondrial efficiency, meaning more energy and focus for the long haul. Use code NAT15 at checkout to get 15% off your purchase. Visit wizardsciences.com.    Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

The Neuro Experience
Can Alzheimer's Be Prevented? The Role of Genetics, Hormones & Lifestyle Choices in Cognitive Health

The Neuro Experience

Play Episode Listen Later Apr 23, 2025 55:40


In this conversation with Dr. Heather Sandison, we explore what I consider to be one of medicine's most significant misunderstandings—that Alzheimer's disease, particularly in women, is an unstoppable fate. We examine the evidence behind cognitive decline, hormones, lifestyle interventions, and a framework for preventing and even reversing what was once considered irreversible.If you're interested in making evidence-based decisions about your brain health, understanding why traditional approaches have failed, or learning about the powerful role of lifestyle interventions in cognitive function, this episode provides both the scientific rationale and actionable strategies you need.Subscribe to The Neuroscience Experience for more conversations that challenge conventional thinking about brain health. I'm committed to bringing you insights that transform how we approach cognitive aging and performance. SponsorsA huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts:Hone Health – Take control of your hormones with at-home testing designed specifically for men. Get personalized insights and expert guidance to optimize your health and performance. Learn more at: https://honehealth.com/Momentous – Science-backed supplements trusted by elite athletes and experts. Whether you're looking to improve recovery, performance, or overall wellness, Momentous has you covered. Use code NEURO for 20% off your order: https://www.livemomentous.com/neuroTroscriptions – Unlock your cognitive potential with precision-dosed nootropics developed by medical experts. Whether you need more focus, clarity, or energy, Troscriptions offers innovative solutions.- Get 10% off: https://troscriptions.com/NEURO- https://troscriptions.com/discount/NEUROMAIL?utm_source=affiliate&utm_medium=email&utm_campaign=NeuroMail Episode Timestamps:  00:00 Why Are Women More Vulnerable to Alzheimer's? 06:13 The Role of Hormone Replacement Therapy 11:24 Understanding Alzheimer's Disease and Dementia 17:04 Alzheimer's Drugs vs. Lifestyle Interventions That Work 29:50 APOE Gene, Genetic Risk, Lipids, and Cholesterol in Alzheimer's 37:47 How the Ketogenic Diet Impacts Brain Health 41:11 GLP-1 Agonists and Their Role in Cognitive Health 44:30 How Infections Contribute to Cognitive Decline 48:00 Plasma Exchange and Alternative Therapies 52:09 Foundational Health Practices & Dual Task Exercise 54:17 Conclusion and Further Resources The Neuro Athletics Newsletter Instagram: @louisanicola_Twitter : @louisanicola_YouTube: @Louisa NicolaThe Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman

Mind & Matter
Cancer Biology: Metabolism, Mitochondria & Energy | Thomas Seyfried | 224

Mind & Matter

Play Episode Listen Later Apr 23, 2025 112:21


Send us a textShort Summary: Cancer's metabolic roots with Dr. Thomas Seyfried.About the guest: Thomas Seyfried, PhD is a professor of biology at Boston College. He has researched cancer metabolism, epilepsy, and lipid biochemistry for over 40 years.Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Transcript and other information on Substack.Episode Summary: Dr. Thomas Seyfried discusses the mitochondrial metabolic theory of cancer, challenging the dominant somatic mutation theory. He explores how cancer cells rely on fermentation due to defective oxidative phosphorylation, drawing on Otto Warburg's work. Seyfried explains how ketogenic diets and nutritional ketosis can starve cancer cells by limiting glucose and glutamine, while sharing evidence from nuclear transfer experiments and clinical studies. The conversation also covers environmental factors driving cancer and the importance of metabolic flexibility for prevention.Key Takeaways:Cancer is characterized by dysregulated cell growth, but Seyfried argues it stems from mitochondrial dysfunction, not just genetic mutations.Cancer cells ferment glucose & glutamine, unable to use fatty acids or ketones, making ketogenic diets a potential therapeutic tool.Nuclear transfer experiments show cancer traits reside in the cytoplasm, not the nucleus, challenging the somatic mutation theory.Environmental factors like processed foods, stress, and poor sleep disrupt mitochondrial function, increasing cancer risk.Seyfried's glucose-ketone index helps monitor metabolic states to manage cancer & chronic diseases.Cancer rates are rising in younger people, possibly due to obesity, inflammation, and environmental toxins.Metabolic flexibility, cycling between ketosis and carb-based states, may mimic ancestral patterns and reduce chronic disease risk.Related episode:M&M #215: Cancer Metabolism: Sugar, Fructose, Lipids & Fasting | Gary PattiSupport the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts

Sigma Nutrition Radio
Do Lipids Increase During Weight Loss? (SNP39)

Sigma Nutrition Radio

Play Episode Listen Later Apr 15, 2025 20:03


This is a segment from one of our Premium-exclusive AMA (ask me anything) episodes, where we answer questions submitted by Premium subscribers. To listen to the full episode, you'll need to be a Premium subscriber and access the episode on the private Premium feed. Questions Answered in This Episode [02:00] Why does the Mediterranean diet emphasize monounsaturated fats over polyunsaturated fats when the latter seem more beneficial for heart health? [08:48] What dietary patterns or foods best support strength and recovery in premenopausal women, especially on a plant-based diet? [20:33] Are there specific foods or supplements that help regenerate or protect connective tissue in conditions like EDS? [28:39] What does the current evidence say about the keto diet during cancer treatment, and are there specific cancers where it might be beneficial? [43:31] What are the biochemical processes behind fat loss, including fat mobilization, transport, and any potential short-term cardiovascular risks? [59:48] What is the most effective system for organizing, structuring, and retrieving accumulated knowledge over time? [1:10:37] Do you agree with Dr. Tom Dayspring that a significant percentage of people are hyper-absorbers of dietary cholesterol, making food cholesterol impactful for them? [1:14:35] Is consuming 2g of protein per pound of body weight safe if calorie intake is high and well-balanced? Links Subscribe to Sigma Nutrition Premium Go to sigmanutrition.com

Dietitian Dad
Ep 72: The “Lipid” Episode

Dietitian Dad

Play Episode Listen Later Apr 14, 2025 17:58


Are you aware of your lipid profile? You need to be..and Dietitian Dad (Mike) explains why in this informative episode. He looks at the latest studies on how to raise HDL (good cholesterol) levels as well as other recent studies around fat/cholesterol. Plus: a new restaurant just opened in his area and this set off a nerve..get ready for a rant! Enjoy and don't forget to leave a review!!

Barbell Shrugged
Physiology Friday: [Cholesterol] How to Read Bloodwork for Lipids, Triglycerides, and Fatty Acids w/ Anders Varner, Doug Larson, and Dan Garner Barbell Shrugged

Barbell Shrugged

Play Episode Listen Later Apr 11, 2025 44:22


In today's episode of Barbell Shrugged you will learn: What are lipids What is cholesterol The difference between HDL and LDL cholesterol Why there is no such thing as “good” or “bad” cholesterol What are the bloodwork numbers for optimal cholesterol What is the perfect ratio of HDL and LDL Ratios for Triglycerides to HDL for optimal health Mechanisms for regulating cholesterol in the liver Why saturated fats are not bad and how your body uses them Cholesterols role in testosterone production To learn more, please go to https://rapidhealthoptimization.com Connect with our guests: Anders Varner on Instagram Doug Larson on Instagram Coach Travis Mash on Instagram Dan Garner on Instagram

The blondEST
The Lipid Serum Glow-Up with Eduardo Perez

The blondEST

Play Episode Listen Later Apr 7, 2025 46:15


Savanna and Tyler are joined by Eduardo Perez, the genius Chief Science Officer behind Epicutis Skincare! From the roots of chia seeds and collagen-saving magic to groundbreaking studies on TSC and retinoids, they're spilling the sciencey tea. They dive deep into why Lipid Serum is basically liquid ibuprofen for your face, the truth about skincare innovation, and what's next for Epicutis (spoiler: new launch incoming

The Daily Apple Podcast
Custom Care, Real Relationships: How Concierge Medicine Changes the Game with Dr. Matt Kaeberlein

The Daily Apple Podcast

Play Episode Listen Later Apr 1, 2025 46:27


Send us a textImagine a healthcare experience where your doctor truly knows you, your concerns aren't rushed, and your wellness plan is as unique as you are. That's the heart of Concierge Medicine—a personalized, proactive approach that puts the focus back where it belongs: on you.In this episode taken from The Optispan Podcast with Dr. Matt Kaeberlein, we explore how deeper doctor-patient relationships, cutting-edge diagnostics, and tailored care are redefining what it means to stay healthy.What you'll learn:More time, more care – How longer, unrushed visits lead to better health outcomesBeyond the basics – The advanced tests and tools that provide a clearer picture of your well-being Surprisingly accessible – Why Concierge Medicine isn't just for the ultra-wealthy Designed for your lifestyle – From athletes to longevity seekers, how personalized care fits your needs 

MedEvidence! Truth Behind the Data

MedEvidence! Truth Behind the Data

Play Episode Listen Later Apr 1, 2025 9:02 Transcription Available


Send us a textCardiologist Dr. Michael Koren joins Kevin Geddings to discuss progress in the world of cholesterol management. Dr. Koren explains the importance of getting cholesterol - especially LDL cholesterol - under control and the potential benefits to heart attack and stroke risk. They discuss some of the problems with current therapies; they are highly effective but can introduce burdens to patients with the back-and-forth for multiple medications. Dr. Koren then reveals new medicatiosn being studied which may combine multiple cholesterol medications into a single pill, reducing barriers and  potentially improving outcomes.Be a part of advancing science by participating in clinical research.Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.comListen on SpotifyListen on Apple PodcastsWatch on YouTubeShare with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramX (Formerly Twitter)LinkedInWant to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.comMusic: Storyblocks - Corporate InspiredThank you for listening!

Grad Chat - Queen's School of Graduate Studies
Margot Smith (Geography) – An Astrobiologists’s study of lipids in spring waters up in the high Arctic

Grad Chat - Queen's School of Graduate Studies

Play Episode Listen Later Apr 1, 2025 29:07


The Arctic is host to cold, hypersaline, perennial springs that flow through 600m of permafrost.  I studied 44 samples from cores, sediments, filtrates and microbial mats from these springs. Surficial life at these springs has been studied for decades, but this is the first investigation that looks at the deep subsurface life. This is of interest as a Mars analogue site for deep subsurface life on Mars. For upcoming interviews check out the Grad Chat webpage on Queen’s University School of Graduate Studies & Postdoctoral Affairs website.

First Call Out Fitness Presents: Step by Step
EP3: Heart Health, Lipid Panels, & Bodybuilding

First Call Out Fitness Presents: Step by Step

Play Episode Listen Later Mar 31, 2025 59:55


The guys come together this month to discuss heart health, lipids, and mitigating the risks that come with bodybuilding.We aimed to be helpful and not to science-y so everyone can understand what we discussed today. We cover - risk factors to pay attention to, tests and scans to run, supplements to keep year round for heart and lipid health, and more."The Sensible Solutions Coaching Podcast" is raw, real, direct, applicable, and empathetic fitness coaching advisory - we aim to cut through the complexity and madness with free knowledge to help coaches, clients, and all fitness enthusiasts keep progress simple.It is the ONLY podcast you'll need to think, learn, laugh, and level up!If you learned something from this podcast episode, please leave us some stars, a review, or share us with a client or coaching friend.Happy coaching!@beoppositetraining @austinst8 @firstcalloutfitness @ericalper_firstcalloutfitness

High Yield Family Medicine
#30 - Lipid Disorders & Obesity

High Yield Family Medicine

Play Episode Listen Later Mar 27, 2025 29:26


Q-BANK: https://patreon.com/highyieldfamilymedicineIntro 0:35,Dyslipidemias 1:48,Statins 4:24,Statin side effects 6:22,Non-statin lipid lowering medications 8:17,Familial Hypercholesterolemia 11:45,Obesity 12:52,Weight loss medications 15:25,Bariatric surgery 19:04,Practice questions 22:19,

The Gaining Health Podcast
The Lipid Neighborhood with Josh Wageman PhD, DPT, CLS, CSCS

The Gaining Health Podcast

Play Episode Listen Later Mar 26, 2025 40:50


Curious about lipids? Do you know what to do with LPa and ApoB?Listen in this week as host Karli Burridge speaks with Josh Wageman, author of the newly released book titled: "The Home Security System and the Lipid Neighborhood: Un-Complicating Cholesterol and Cardiovascular Disease"It sounds like the start of a bad joke…or perhaps a confusingly awesome dream. A Physical Therapist, ex-collegiate track athlete, Ivy league grad, Youth Pastor, and some dude with a PhD start having a conversation about cholesterol. And then you realize all those guys are THE SAME GUY, and that guy takes you on a whimsical pilgrimage that results in YOU having a framework for NOT having heart attacks, strokes, and dementia. Employing a smorgasbord of metaphors, pictures, and catchphrases, The Home Security System and the Lipid Neighborhood serves as a valuable reference for clinicians and non-clinicians alike, bringing refreshing relatability to complex biochemical topics. Through a lipid-lens, you'll learn, laugh, and love your way through its pages…and in the end, you'll undoubtedly add “life to your years!”Available at: https://www.amazon.com/dp/B0DR33FPZF?ref_=pe_93986420_775043100On X: https://x.com/joshjwagemanInstagram Tag is @wagemanjosh and you're welcome to find Josh on LinkedIn and FacebookSupport the showThe Gaining Health Podcast will release a new episode monthly, every second or third Wednesday of the month. Episodes including interviews with obesity experts as well as scientific updates and new guidelines for the management of obesity.If you're a clinician or organization looking to start or optimize an obesity management program, and you want additional support and resources, check out the Gaining Health website! We offer a Roadmap to starting an obesity program or practice, pre-recorded Master Classes, digital resources including patient education materials and office forms, and much more! Check out our resources on our Gaining Health Shop! If you are loving this podcast, please consider supporting us on Patreon

Cardionerds
414. Case Report: Got Milky Blood? Hypertriglyceridemia Unveiled in a Case of Abdominal Pain – National Lipid Association

Cardionerds

Play Episode Listen Later Mar 25, 2025 77:42


CardioNerds co-founders Dr. Daniel Ambinder and Dr. Amit Goyal are joined by Dr. Spencer Weintraub, Chief Resident of Internal Medicine at Northwell Health, Dr. Michael Albosta, third-year Internal Medicine resident at the University of Miami, and Anna Biggins, Registered Dietitian Nutritionist at the Georgia Heart Institute. Expert commentary is provided by Dr. Zahid Ahmad, Associate Professor in the Division of Endocrinology at the University of Texas Southwestern. Together, they discuss a fascinating case involving a patient with a new diagnosis of hypertriglyceridemia. Episode audio was edited by CardioNerds Intern Student Dr. Pacey Wetstein. A woman in her 30s with type 2 diabetes, HIV, and polycystic ovarian syndrome presented with one day of sharp epigastric pain, non-bloody vomiting, and a new lower extremity rash. She was diagnosed with hypertriglyceridemia-induced pancreatitis, necessitating insulin infusion and plasmapheresis.   The CardioNerds discuss the pathophysiology of hypertriglyceridemia-induced pancreatitis, potential organic and iatrogenic causes, and the cardiovascular implications of triglyceride disorders. We explore differential diagnoses for cardiac and non-cardiac causes of epigastric pain, review acute and long-term management of hypertriglyceridemia, and discuss strategies for the management of the chylomicronemia syndrome, focusing on lifestyle changes and pharmacotherapy.  This episode is part of a case reports series developed in collaboration with the National Lipid Association and their Lipid Scholarship Program, with mentorship from Dr. Daniel Soffer and Dr. Eugenia Gianos. US Cardiology Review is now the official journal of CardioNerds! Submit your manuscript here. CardioNerds Case Reports PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls - Hypertriglyceridemia Cardiac sarcoidosis can present with a variety of symptoms, including arrhythmias, heart block, heart failure, or sudden cardiac death. The acute management of hypertriglyceridemia-induced pancreatitis involves prompt recognition and initiation of therapy to lower triglyceride levels using either plasmapheresis or intravenous insulin infusion +/- heparin infusion. Insulin infusion is used more commonly, while plasmapheresis is preferred in pregnancy.   Medications such as fibrates and omega-3 fatty acids can be used to maintain long-term triglyceride reduction to prevent the recurrence of pancreatitis, especially in patients with persistent triglyceride elevation despite lifestyle modifications. Statins can be used in patients for ASCVD reduction in patients with a 10-year ASCVD risk > 5%, age > 40 years old, and diabetes or diabetes with end-organ damage or known atherosclerosis. Consider preferential use of icosapent ethyl as an omega-3 fatty acid for triglyceride lowering if the patients fit the populations that appeared to benefit in the REDUCE IT trial.   Apply targeted dietary interventions within the context of an overall healthy dietary pattern, such as a Mediterranean or DASH diet. Limit full-fat dairy, fatty meats, refined starches, added sugars, and alcohol. Encourage high-fiber vegetables, whole fruits, low-fat or fat-free dairy, plant proteins, lean poultry, and fish. Pay special attention to the cooking oils to ensure the patient is not using palm oil, coconut oil, or butter when cooking. Instead, use liquid non-tropical plant oils. Initiate a very low-fat diet (< 5% of total daily calories from fat) for 1-4 weeks when TG levels are > 750 mg/dL.  Recommend and encourage patients to exercise regularly, with a minimum goal of 150 minutes/week of moderate-intensity aerobic activity. If weight loss is required, aim for more than >225 - 250 minutes/week.   Develop patient-centered and multidisciplinary stra...

Mind & Matter
Cancer Metabolism: Sugar, Fructose, Lipids & Fasting | Gary Patti | 215

Mind & Matter

Play Episode Listen Later Mar 19, 2025 105:17


Send us a textShort Summary: How dietary fructose affects the growth rate of cancer.About the guest: Gary Patti, PhD is a professor at Washington University in St. Louis, holding appointments in chemistry, medicine, and geneticsNote: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.Episode Summary: Nick Jikomes talks to Dr. Patti, exploring how cancer cells metabolize sugars like glucose and fructose, focusing on a recent study showing fructose indirectly boosts tumor growth in mice via liver-produced lipids called LPCs. The discussion covers cancer biology basics, Warburg effect, tumor microenvironments, and systemic metabolic impacts of cancer, while also touching on dietary implications, fasting, and the complexities of nutrient use in cancer progression.Key Takeaways:Cancer cells often rely heavily on glucose, excreting it as lactate even when oxygen is available (Warburg effect), but take up more than their mitochondria can handle.In a study, high fructose diets accelerated tumor growth in mice by 4x, not because cancer cells use fructose directly, but because the liver converts it to LPCs, which tumors use to build membranes.Tumors are not just cancer cells; they recruit healthy cells in their microenvironment, and their metabolic effects ripple across the entire body, altering distant tissues.Excessive fructose consumption may worsen tumor growth, but cutting it poses little risk and could benefit cancer patients, pending human studies.Fasting may reduce cancer initiation risk in animals, but its effect on existing tumors is less clear and could worsen wasting (cachexia) in late stages.The body tightly regulates blood glucose via the liver, so simply cutting dietary glucose won't starve tumors, highlighting cancer's metabolic adaptability.Related episode:M&M #200: Dietary Fats & Seed Oils in Inflammation, Colon CancerSupport the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts

Prevmed
Lipid Experts: LDL DOESN'T ALWAYS Clog Arteries - Ford Brewer MD MPH - PrevMed Health

Prevmed

Play Episode Listen Later Mar 16, 2025 114:36


Ready to reverse your chronic disease? Dr. Ford and the PrevMed staff are currently accepting new patients for a limited time. Book an appointment here: https://prevmedhealth.com/To ensure quality of care there are limited openings available so act quickly.

Healthy Looks Great on You
Cholesterol: Good vs. Bad

Healthy Looks Great on You

Play Episode Listen Later Mar 14, 2025 22:01


 You've gone to the doctor and had your cholesterol checked, but what do all those numbers mean? And is there anything you can do to lower your cholesterol without medications? I'm so glad you asked.  I'm Dr.Vickie Petz Kasper. If you're ready to take control of your health, you're in the right  place. Whether you're focused on prevention or you're trying to manage a condition. I'll give you practical steps to start your own journey toward better health because healthy looks great on you.  This is episode 1 64. Cholesterol, the Good versus the Bad. When I was about 26 years old, I had my cholesterol checked for the first time. Imagine my surprise when the number was 256.  Yikes. Now admittedly, the hospital where I was doing my residency had a fast food restaurant conveniently located right there in the cafeteria and my go-to: hamburgers and french fries. But also I have a strong family history of significantly elevated cholesterol.  The doctor said I could lower it some and I should diet and exercise and blah, blah, blah, blah, blah, blah, blah. But guess what? I eventually lowered my cholesterol to 156 without medication, and I'm going to tell you how you can do it too. But first, let's start at the beginning and go to mini medical school and learn exactly what is cholesterol. Technically we call it a lipid, which is sort of like a fat that circulates in your bloodstream. Structurally, these compounds make up parts of cell membranes and functionally they help regulate the transport across these membranes, so that's good. Right? Well, yes, we do need cholesterol to help move and store energy, produce hormones, and absorb vitamins. But you know, too much of a good thing. We'll get to that. Lipids don't dissolve in water, so they have to hitch a ride on proteins to travel through the blood, and when they get hitched, they change their name to lipoproteins. Now this is gonna sound familiar if you've ever had a lipid panel drawn.  HDL stands for high density lipoproteins and LDL stands for low density lipoproteins.  Where does it come from? Well, your body actually makes it in both the liver and small intestines. Then it's stored in the liver where it's converted to bile acids, so you can get rid of it. Is it bad or good? Well, that depends. HDL cholesterol reduces inflammation, prevents blood clots, and helps transport oxygen. And your body makes all of it that you need all of it. But here's the deal. Not only does your body make cholesterol, but we also eat it. Most of the cholesterol in the standard American diet comes from meat, eggs, cheese, and dairy products. Oh, well, who can afford eggs anyway? But seriously, cholesterol is sneaky. Rather than announcing its presence, it just slips through your blood vessels undetected, but it leaves a calling card and we call it plaque. This buildup in the wall of the arteries can lead to hardening of the arteries and therefore cardiovascular disease. Think about it. If a plaque gets big enough, it can compromise blood flow and cause a heart attack or stroke. And this can also happen with smaller plaques when a piece breaks off. I told you cholesterol is sneaky. Most people who have high cholesterol have no symptoms. We call it hyperlipidemia, and that's why you need to know your numbers and you need to know what they mean.  I guess all those burgers weren't helping me have healthy blood vessels when I was in my twenties.  But that's not the whole story. We could go to mini medical school and learn the difference between HDL and LDL cholesterol, or we could just call them good cop, bad cop. Because that kind of sums it up. The reason LDL cholesterol is the bad cop is because it causes a fatty buildup inside the arteries and that impairs blood flow and puts you at increased risk of a heart attack or stroke. You've seen those detective shows where they lock someone in an interrogation room and they just yell at 'em. No, it's not exactly the same, but I bet you'll remember now that LDL the bad cop cholesterol can make you have a heart attack. Now the good cop HDL cholesterol can actually lower your risk of heart disease and stroke. You know, it's the reassuring I'll be your friend cop. Picture the scene, bad cop is giving the suspect a really hard time and good cop comes in and sends the bad cop away.   Stick with me here. HDL, good cholesterol carries at least a little bit of the LDL or bad cholesterol out of the arteries where it causes damage and into the liver where it can be broken down and eliminated. So speaking in very general terms, you want your HDL cholesterol to be high and your LDL cholesterol to be low. We'll get to specific numbers in a sec. I do want to mention triglycerides. They are not the same thing as cholesterol, but they hang out together because you know, birds of a feather... When you have a lipid panel done, they often measure the whole flock, total cholesterol, HDL cholesterol, LDL, cholesterol and triglycerides. You've also probably heard about the ratio and yes, it's very important, but whose side are these triglycerides on anyway? Well, they're the most common type of FAT in the body. And like all things in our bodies, they have a purpose and that is to store excess energy from your diet. And yeah, that's the problem. Most of us have plenty of excess in our diet.  Hamburgers and french fries, or as Steve Martin said in the old Pink Panther movie, "Am barger." If you don't know that scene and that didn't make you laugh, please google it and watch a clip.  The bottom line is that high triglycerides combined with high LDL means fatty buildup in the walls of the arteries, and that increases the risk of heart attack and stroke. Okay, I hope you're convinced that Steve Martin is hysterical and you need to see the clip from the Pink Panther, and you need to get your cholesterol checked.  You are convinced, right? Don't believe me. The American Heart Association recommends that if you are over the age of 20, you should have your cholesterol checked and depending on your risk factors, every four to six years after that, until you get older and have an increased risk of. every dang thing. So now you've had your blood drawn and the doctor calls you with your results.  No. Oh yeah. Your results are now on the portal and you want to know what they mean.  I do have to tell you that context matters and you really should discuss the results with your doctor, but if you don't hear from them, I'll give you some generalities for people who do not already have cardiovascular issues, and by the way, you should fast for at least 12 hours before you go to the lab and get this. You shouldn't have the test done if you're sick or stressed. Stress affects cholesterol too. It wreaks havoc on your body in so many ways. First of all, people who are stressed often smoke more, drink more, sleep less, exercise less socially isolate and eat more junk. So there's that, but also our old friend Cortisol, the stress hormone also plays a role. Cortisol is our body's way of preparing us to physically respond to a threat. So it triggers the release of glucose and fatty acids into the bloodstream and muscles. So energy is available for slaying dragons   threatening our safety, and that's a good thing when there are dragons pulling up in your driveway. Not so much if you live in a constant state of stress. Of course, if you have prolonged stress, you'll have to go ahead and surrender that vein in your arm and get your lipids checked anyway, because when it comes to your numbers, you need to know. So let's get to those numbers. Total cholesterol should be below 200 milligrams per deciliter, and if it's between 201 and 239, that's considered borderline high cholesterol, and if it's above 240, that's just plain over the limit. Now, LDL cholesterol should be below 130 or even much lower than that if you are at risk of heart attack or stroke, HDL should ideally be above 60 and triglycerides below 150. Any numbers outside of these parameters should be taken seriously because you have a higher risk of cardiovascular disease, especially if you continue to eat ham ba burgers.  Now, let's say you do hear from your doctor's office. You know, the nurse calls and says you either need to take a cholesterol lowering medication like a statin or that you need to eat a low cholesterol diet and exercise. Thank you very much. But shouldn't we have a more detailed conversation about this result?  You bet. Your cholesterol is just one group of numbers. It's not the whole picture. Your risk of heart disease is impacted by other factors like smoking, high blood pressure, your family history, your age, and yes, of course your diet. And we are going to talk about a heart healthy diet in a bit. But first, let's discuss that conversation you're having with the nurse who calls from the doctor's office and said, we've sent in a prescription for a statin.  Hold up a minute. This literally happened to me last year. My total cholesterol was 202, a whopping two points above the normal range, and my ratio of good cholesterol to bad cholesterol was excellent. So I questioned this recommendation,  but what are the recommendations? Remember, I am board certified in lifestyle medicine, which is a subspecialty of conventional medicine. So we're not opposed to treatment with medication when indicated, but before we go firing off prescriptions, we should at least examine the indications. If your cholesterol is abnormal, and I would argue that mine is not thanks to some serious changes in my lifestyle and not my inherited tendencies, then you may need a cholesterol medication. Depending on your age and the likelihood of developing heart disease, but if you're not at risk for heart disease, then you might not need a medication, even if your cholesterol is high. At least not for now, because here's the deal, the number of your years only increases and age is a risk factor for heart disease, which by the way, is the number one killer of Americans. So let's say you are at risk and your cholesterol is high and your doctor wants you to take a medication quick pharmacology review. These medications can help the body make less cholesterol, which is one source. They can block the absorption of cholesterol from food, which is another source, and on top of that, they can actually help your body get rid of cholesterol faster. Sounds great. Right, and it can be, you should probably take medication if you have known heart disease, especially if you've actually had a heart attack or stroke. And because diabetes is such a big risk factor for cardiovascular disease, you may need to take a medication if you have type two diabetes, even if your cholesterol isn't high. And that's to prevent heart disease. Of course, you need to discuss all of this with your personal healthcare provider, and I recommend following their advice after you've had a conversation about options and risk. The most commonly prescribed class of medications are statins, but there are others. But can you lower your cholesterol without medications? I'm living proof  exercise helps raise your good cholesterol and lower your bad cholesterol, but you gotta do it regularly. Ideally, 30 minutes, five days a week, or if you wanna step it up a notch, 20 minutes of vigorous exercise three times a week. And remember, vigorous means you cannot have a conversation if you're talking, you are not exercising vigorously. You gotta be huffing and puffing to reach this level. So if you decide to stick with moderate, you can talk, but you can't sing. But here's the beauty of exercising - every little step in the right direction has immediate benefits, so you can start small and see results. Resistance training is great to build muscle strength and burn energy. You know, bands, weights, pushups, things like that. Or maybe you could start walking briskly. Or go to the gym and join a class for built-in accountability and social connections.   Let me give you a startling fact.  People who have a heart attack are four times more likely to die within three years if they don't have social connections. The older you get, the stronger the association. And if you're wondering how in the world that could be, it turns out the key is caring about others. When you value people in your life and you know they value you, you are more likely to make healthier choices like not smoking and positive relationships help manage stress and lower inflammation, and that damages blood vessels and also contributes to heart disease.  Sleep matters too. As part of an overall healthy lifestyle, you should aim for seven to nine hours per night and less than six hours a night is associated with higher cholesterol levels.  In the past, medical literature reported a positive association between drinking a glass of red wine and heart health. Turns out that's probably not true and moderate to heavy drinking  unquestionably raises your risk for heart disease. You know, if your liver's working overtime to get rid of alcohol, it's much less effective in dealing with cholesterol. Now, your Dr. may not have mentioned any of this except diet and exercise. So let's park there for a minute. A healthy weight is often associated with better numbers, but that isn't always true. Genetics also plays a big role, but whether you're at an ideal weight or overweight, changing your diet can have a huge impact on your cholesterol. In fact, depending on how much change you're willing to make, I would say that you can lower your cholesterol to a healthy level. And if you're interested in making healthy habit changes, you might want to go to my website Healthy Looks Great on you.com and sign up for Kickstart to Better Health. And for sure, you're going to want to stay tuned for an upcoming interview I have on Habit Change. Subscribe to this podcast. There's a link in the show notes or go to the website Healthy looks great on you.com. Either way, you should listen to your doctor. And make sure they listen to you as well. You may need medication to lower your cholesterol, and you may need to make lifestyle changes, especially if your numbers are going up in the wrong direction, even a little. But if you're motivated to do it without medications, let me harp on your diet. Hear me when I say this. When it comes to cholesterol or weight loss, diet matters more than exercise. Of course you should do both, but if you don't change your diet, exercise may not have the impact you're looking for. If you want to reduce the intake of cholesterol, stay away from trans fats, sometimes referred to as partially hydrogenated oils. They've basically been outlawed and banned anyway, but sometimes these transitions take some time to implement. Just make sure packaged pastries and things like margarine, which you shouldn't be eating anyway, don't have them. Avoid foods that are high in any kind of saturated fat.   Here's my top five list of foods that are high in cholesterol. Maybe we can find some hints about why my cholesterol was high eating in that fast food restaurant every day. Number one is red meat, beef, pork,  and especially processed meats like bacon, sausage, and hot dogs. Ah, remember what those hamburgers did to my cholesterol numbers. Number two is fried foods, and yes, I ordered french fries with my burgers. And fried foods are particularly bad when certain oils are used. Number three is sugar sweetened beverages and good grief. I drank a Coke with my burger and fries. No wonder my numbers were bad. Number four is sweets, pastries, pies, cakes, cookies, and ice cream. Yep. I probably ate that too. Number five is dairy, especially whole milk, cream, butter, and unfortunately cheese, which I also put on my burger. Good grief. I was daring my cholesterol to be high with all the foods from the naughty list. So what am I doing now? Well, I'm glad you asked. Here's a fun fact.  You really don't find cholesterol in plants. So eat plants, eat a lot of plants, eat different plants, eat plants that have different colors. Usually the darker, brighter the color, the more nutrients it has. Cholesterol's only found in processed foods, meat and dairy. But you wanna know what's only found in plants. Fiber and a high fiber diet is so important in lowering your cholesterol. It creates a healthy gut microbiome. Think of it like a sponge too, that soaks up cholesterol out of your bloodstream and helps remove it. Things like unprocessed oatmeal, whole wheat bread, whole grain brown rice, and popcorn. Also, beans, broccoli, sweet potatoes, apples, pears, oranges, grapes, all kinds of berries and nuts are on the good list. You didn't just ask me about eggs, did you? Goodness, that's a whole other conversation. And so is the other player in this conversation, triglycerides. But I will tell you that if you have high LDL cholesterol, you should at least limit your consumption of eggs. And the bottom line is that HDL cholesterol is your friend. It can help protect you from cardiovascular disease. And LDL Cholesterol levels should be low for heart health. That's easy to remember. H stands for high. L stands for low, and in some cases your doctor will want it really, really low. Below 70. So is cholesterol good or bad? The answer is yes. Cholesterol helps with cell membrane transport, absorption of vitamins, brain function, hormone production. But don't get the wrong idea. LDL cholesterol causes fatty buildup in the arteries, and that can be a huge threat to your health. So lower your bad cholesterol with medications if you need it, but definitely lower it with lifestyle changes because lower LDL is better for your health and healthy. Looks great on you.    The information contained in this podcast is for educational purposes only and is not considered to be a substitute for medical advice. You should continue to follow up with your physician or health care provider and take medication as prescribed. Though the information in this podcast is evidence based, new research may develop and recommendations may change 

MedEdTalks - Cardiology
Lipid Legends With Your Host Dr. Ronald Codario, Featuring Dr. Alan Brown: Lp(a) – What You Need to Know

MedEdTalks - Cardiology

Play Episode Listen Later Mar 14, 2025 31:43


In this podcast, expert clinicians will discuss the role of lipoprotein(a) [Lp(a)] in atherogenesis and emerging therapies that reduce Lp(a). To claim CE credit after listening to this episode, go to this link and check the "Already listened on another platform?" box: https://healio.com/cme/mededtalks/cardiology/20250303/5-lipid-legends-with-your-host-dr-ronald-codario

Question of the Week - From the Naked Scientists
How do skin creams penetrate the skin?

Question of the Week - From the Naked Scientists

Play Episode Listen Later Mar 7, 2025 4:55


Garth wants to know, given the skin can block water from passing through it, how do certain skin creams allege to permeate into our body? James Tytko took on the question with help from Richard Guy, Professor of Pharmaceutical Sciences at the University of Bath... Like this podcast? Please help us by supporting the Naked Scientists

FoodNavigator-USA Podcast
Lipid luminary: Environmentally conscious fats and oils take the spotlight under Checkerspot's new CEO

FoodNavigator-USA Podcast

Play Episode Listen Later Mar 3, 2025 19:50


Under John Krzywicki's leadership, US-based biotech company Checkerspot will refine its focus on using microalgae and precision fermentation to develop sustainable high value triglyceride fats and oils not easily sourced from nature at commercially relevant scale and cost

Brains and Gains with Dr. David Maconi
Aaron Straker + Bryan Boorstein - CGM, Cholesterol, Food Enjoyment, Low Volume

Brains and Gains with Dr. David Maconi

Play Episode Listen Later Mar 1, 2025 89:55


0:00- Intro1:00- CGM and Peter Attia's recommendations11:00- Lipids. LDL, ApoB24:00- Hedonic eating31:00- Our super power to manipulate weight33:00- Health ramifications of excess junk food37:00- Exercise “snacks” and intermittent exercising40:00- Levels of enjoyment from food49:00- Hunger and appetite55:30- Calorie cycling59:30- What it takes to maintain peak physique and performance1:01:00- Low volume training1:20:00- Aaron's PED update

MedEdTalks - Cardiology
Lipid Legends With Your Host Dr. Ronald Codario, Featuring Dr. James Underberg: Familial Hypercholesterolemia – Risk Assessment and Treatment

MedEdTalks - Cardiology

Play Episode Listen Later Feb 28, 2025 33:25


In this podcast, expert clinicians will assess the latest understanding regarding homozygous and heterozygous familial hypercholesterolemia (FH), risk assessment, and options for management. To claim CE credit after listening to this episode, go to this link and check the "Already listened on another platform?" box: https://healio.com/cme/mededtalks/cardiology/20250211/3-lipid-legends-with-your-host-dr-ronald-codario-featuring-dr-james-underberg Read More  

Forever Young Radio Show with America's Natural Doctor Podcast
Episode 586: Ep 586 Occasional muscle pain? Think PEA

Forever Young Radio Show with America's Natural Doctor Podcast

Play Episode Listen Later Feb 27, 2025 44:29


To help us unpack all the research and studies we have Dr. Stengler joining us today.In addition to authoring 30 books on health and several best-sellers such as “The Natural Physician's Healing Therapies,” “Prescription for Natural Cures,” “Prescription for Drug Alternatives,” and “Outside the Box Cancer Therapies,” Dr. Stengler has been published in several peer-reviewed medical journals such as The International Journal of Family & Community Medicine, Endocrinology & Metabolism International Journal, and Journal of Nutritional Health & Food Engineering.The newest book is called, The Holistic Guide to Gut Health. A comprehensive yet accessible approach to healing leaky gut and the many uncomfortable symptoms it causes. Dr Stengler is also the founder of The Stengler Center for Integrative Medicine.Talking Points:Palmitoylethanolamide (PEA), is a naturally occurring fatty acid derivative made in the body and found in small amounts in foods. Several human studies have demonstrated that PEA has broad-spectrum pain-relieving properties, anti-inflammatory effects, and nerve protection.PEA was first discovered in 1957 by scientists at Merck Sharp & Dohme, who isolated it from egg yolk, peanut meal, and soy lecithin. They found that PEA had anti-inflammatory properties in guinea pigs.However, PEA's role as a potential therapeutic agent was not widely recognized until 1993, when Rita Levi-Montalcini and her colleagues published research that suggested PEA has anti-inflammatory properties. Levi-Montalcini's group termed PEA an autocoid local injury antagonist (ALIA), and suggested that it acts locally to counteract injuryMultiple studies have demonstrated that PEA improves all sorts of pain. For example, a 2023 analysis of 11 studies found that PEA improved pain of various conditions, including muscle and joints, nerves, gynecological, and digestive. In terms of joint pain, a high-quality study demonstrated that PEA significantly reduced adult joint pain compared to placebo. Moreover, 8 clinical trials demonstrated that PEA was effective for low back pain, sciatica, and carpal tunnel syndrome. Even migraine headache pain was shown in published research to be improved with PEA.Lipid mediators help to balance the immune, nervous, and endocrine systems, affecting pain pathways related to inflammation. But unfortunately, due to changing diets, many of us do not get the nutrition and activity we need to make enough PEA ourselves.Supplemental PEA, by Levagen+ is properly formulated for optimal bioavailability, 75% more bioavailable to cell receptors than dietary formsLevagen+ liposomal delivery of PEA has been clinically studied and shows benefits in joint pain, nerve pain, migraine, infections, sleep, and cognitive function.Learn more about Emerald Labs PEA+ Levagen Use the code: Forever and get 20% off your order.

Performance Medicine Audio
Lipid Panels | Explain This Ep. 111 w/ Robin Riddle, FNP-C

Performance Medicine Audio

Play Episode Listen Later Feb 22, 2025 14:56


In this episode, Robin Riddle, FNP-C explains what a lipid panel is, what it measures, and how it is interpreted in integrative medicine.What did you think of this episode of the podcast? Let us know by leaving a review!Connect with Performance Medicine!Check out our new online vitamin store:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://performancemedicine.net/shop/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Sign up for our weekly newsletter: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://performancemedicine.net/doctors-note-sign-up/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@PMedicine⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@PerformancemedicineTN⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Performance Medicine⁠

Mayo Clinic Cardiovascular CME
Lipid Drugs: Part 2

Mayo Clinic Cardiovascular CME

Play Episode Listen Later Feb 18, 2025 12:26


Lipid Drugs: Part 2   Guest: Alicia A. Mickow, APRN, C.N.P., M.S.N Host: Stephen L. Kopecky, M.D.   In Part 2, we will explore potential side effects and barriers to prescribing these medications, considering various patient factors. If you missed Part 1 last week, we encourage you to listen to it first, as this episode serves as a continuation and conclusion of that discussion.   Topics Discussed: Side effects of these newer non-statin drugs Barriers to prescribing those drugs   Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices. LinkedIn: Mayo Clinic Cardiovascular Services Cardiovascular Education App: The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today! No CME credit offered for this episode. Podcast episode transcript found here.

Mayo Clinic Cardiovascular CME
Lipid Drugs: Part 1

Mayo Clinic Cardiovascular CME

Play Episode Listen Later Feb 11, 2025 11:15


Lipid Drugs: Part 1   Guest: Alicia A. Mickow, APRN, C.N.P., M.S.N Host: Stephen L. Kopecky, M.D.   In Part 1 of this two-part series, listeners will learn the challenges of managing patients who are statin-intolerant, the range of available treatment options, alternative dosing schedules, and strategies for introducing newer medications. Stay tuned for Part 2, where they will examine the side effects of these newer drugs and barriers to prescribing them.   Topics Discussed: What are the non-stain medications available and how are they different from statins? How do you decide which medication to use when patients are statin intolerant?   Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices. LinkedIn: Mayo Clinic Cardiovascular Services Cardiovascular Education App: The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today! No CME credit offered for this episode. Podcast episode transcript found here.

Pharmacy Podcast Network
Lipid Disturbances in Alzheimer's | Geriatric Pharmacy Focus

Pharmacy Podcast Network

Play Episode Listen Later Feb 10, 2025 50:52


Dr. Tamara Ruggles:  www.linkedin.com/in/tamara-ruggles-491882251 Dr. Josh Wageman:  linkedin.com/in/josh-wageman-48893445 The Home Security System and the Lipid Neighborhood: Un-Complicating Cholesterol and Cardiovascular Disease by Dr. Josh Wageman can be found on Amazon.com beginning February 18, 2025.

The CIRS Group Podcast
When fats matter: Up your lipids to get back your health!

The CIRS Group Podcast

Play Episode Listen Later Feb 5, 2025 15:03


For more information, visit https://thecirsgroup.com or subscribe to our newsletter to join us for our next live Q&A webinar! https://www.thecirsgroup.com/webinar CIRS, or Chronic Inflammatory Response Syndrome, is best treated with the Shoemaker Protocol. Research and clinical experience has shown that patients tolerate the protocol far better when they incorporate lipid replacement therapy. This means more supplements! But not all supplements are created equal. Today we'll cover the most often recommended lipids for you to consider when you start your healing journey. For more information, support, and resources in your own CIRS healing journey, visit TheCIRSGroup.com TIME STAMPS: 0:00 Intro and disclaimer 0:32 Why you start lipid replacement before you start binders 1:14 Side effects of binders that lipid replacement will help you with 3:00 How to know you're taking enough fats 4:02 How fats can impact your MMP9 level 4:52 The danger of taking too much lipid replacement 5:17 The lipid replacement options, starting with fish oils, Omaprem 6:39 Phosphatidylcholine 8:56 Plasmalogens 12:15 Do Neuro when you are in a “good place” 13:25 Consider staying on lipid replacement long term HELPFUL LINKS: Omaprem: https://www.nutritionwithjudy.com/shopping/inflammation/omaprem-spm-fatty-acids Fish Oils: https://shop.bioticsresearch.com/products/biomega-1000 Phosphatidylcholine: https://bodybio.com/products/bodybio-pc-phosphatidylcholine?variant=34379596136583&country=US¤cy=USD&utm_medium=product_sync&utm_source=google&utm_content=sag_organic&utm_campaign=sag_organic&utm_source=google&utm_medium=paid&utm_campaign=17855439090&utm_content=&utm_term=&tw_source=google&tw_adid=&tw_source=google&tw_adid=&tw_campaign=17855439090&gad_source=1&gclid=Cj0KCQiAkoe9BhDYARIsAH85cDMeyrEJAWstHbDJF9kLXOvoOkkwMRr9vNqqvEbSiUdYrXaJodENBlQaAkJsEALw_wcB Plasmalogens: Glia for repair (earlier in the protocol): https://prodrome.com/products/prodromeglia-softgel?variant=50891696930976 Neuro (to promote brain growth): https://prodrome.com/products/prodromeneuro-softgel?pr_prod_strat=jac&pr_rec_id=f4d553f7c&pr_rec_pid=7578764083360&pr_ref_pid=7578764214432&pr_seq=uniform&variant=50891105042592 The CIRS Group: Support Community: https://thecirsgroup.com Join us for our next live Q&A webinar! https://www.thecirsgroup.com/webinar Instagram: https://www.instagram.com/thecirsgroup/ Find Jacie for carnivore, lifestyle and limbic resources: Instagram: https://www.instagram.com/ladycarnivory YouTube: https://www.youtube.com/@LadyCarnivory Blog: https://www.ladycarnivory.com/ Order Jacie's book! https://a.co/d/8ZKCqz0 Find Barbara for business/finance tips and coaching: Website: https://www.actlikebarbara.com/ Instagram: https://www.instagram.com/actlikebarbara/ YouTube: https://www.youtube.com/@actlikebarbara Jacie is a Shoemaker certified Proficiency Partner, NASM certified nutrition coach, author, and carnivore recipe developer determined to share the life changing information of carnivore and CIRS to anyone who will listen. Barbara is a business and fitness coach, CIRS and ADHD advocate, speaker, and a big fan of health and freedom. Together, they co-founded The CIRS Group, an online support community to help people that are struggling with their CIRS diagnosis and treatment.

JACC Podcast
Long-Term Lipid Lowering With Evolocumab in Older Individuals

JACC Podcast

Play Episode Listen Later Feb 3, 2025 62:46


Section 1: Introduction (0:00 - 5:30) Dr. Valentin Fuster introduces a special issue on Prevention, covering societal and individual prevention aspects and key cardiovascular risk factors. He highlights issues like medication adherence, obesity, and the need for better education and healthcare systems. Section 2: Prevention in Society (5:30 - 35:30) Adherence to Medications The PURE trial shows low medication adherence (31% at follow-up) across 17 countries, despite technological advancements in diagnostics. Barriers include low health literacy and inadequate healthcare systems. Social Determinants of Health Social deprivation leads to worse cardiovascular outcomes, especially among sexual minorities in the U.S. The editorial calls for more equitable healthcare access and anti-stigma efforts. Environmental Factors: Aircraft Noise Higher aircraft noise exposure is linked to worse heart health, urging noise reduction policies for vulnerable populations. Section 3: Prevention in Individuals (35:30 - 55:30) Sedentary Behavior Even with exercise, high sedentary time (over 10.6 hours a day) increases cardiovascular risk. Reducing sedentary time can significantly lower heart disease risk. Intensive Lifestyle Interventions for Diabetes Weight loss and lifestyle changes improve cardiac biomarkers and reduce cardiovascular risk in type 2 diabetes patients. Section 4: Risk Factor Impacts (55:30 - 1:10:00) Hyperlipidemia & Obesity Hyperlipidemia and obesity management, including medications like semaglutide, play key roles in preventing cardiovascular disease. The 2024 ESC hypertension guidelines are also crucial in risk reduction.

Your Checkup
Good vs. Bad Cholesterol: A Patient's Guide to Understanding Your Lipid Profile

Your Checkup

Play Episode Listen Later Jan 27, 2025 27:07


Send us a message with this link, we would love to hear from you. Standard message rates may apply.This episode is a comprehensive episode designed to educate listeners about the complexities of cholesterol and its impact on cardiovascular health. The episode defines hyperlipidemia  detailing various types of lipids, including LDL, HDL, and triglycerides. The discussion covers recommended lipid screening guidelines, risk factors, and the importance of personalized risk assessment. By the end of this episode, listeners will have a deeper understanding of cholesterol and will be empowered to take proactive steps towards better heart health.Support the showProduction and Content: Edward Delesky, MD & Nicole Aruffo, RNArtwork: Olivia Pawlowski

The Medbullets Step 2 & 3 Podcast
Cardiovascular | Lipid-Lowering Drugs

The Medbullets Step 2 & 3 Podcast

Play Episode Listen Later Jan 12, 2025 15:51


In this episode, we review the high-yield topic ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Lipid-Lowering Drugs⁠ ⁠⁠⁠⁠⁠⁠⁠⁠from the Cardiovascular section at ⁠⁠⁠⁠⁠⁠Medbullets.com⁠⁠⁠⁠⁠⁠ Follow ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets Linkedin: https://www.linkedin.com/company/medbullets

NP Pulse: The Voice of the Nurse Practitioner (AANP)
135. Lipid Management with Dr. Colleen Walsh-Irwin

NP Pulse: The Voice of the Nurse Practitioner (AANP)

Play Episode Listen Later Jan 1, 2025 17:39


Dr. Colleen Walsh-Irwin joined NP Pulse to discuss updated treatment guidelines for hyperlipidemia and much more. Walsh-Irwin has been an NP for almost thirty years and runs a national program for evidence-based practice. In addition to discussing new medications for treating hyperlipidemia, Walsh-Irwin shares how she utilizes her own visual aides to help her patients understand their health issues and treatment.  And for all things Cardiovascular related, consider joining the AANP Community group: Cardiology Specialty Practice, which offers the opportunity to interactively collaborate with colleagues who share interest or clinical expertise on the subject. 

After Hours with Dr. Sigoloff
142. Richard Hirschman: The Embalmer Exposing Vaccine Injuries

After Hours with Dr. Sigoloff

Play Episode Listen Later Dec 29, 2024 85:17


In this conversation, Dr. Sam Sigoloff interviews Richard Hirschman, a trade embalmer, about the alarming discovery of unusual clots found in deceased individuals, particularly in relation to the COVID-19 pandemic. Hirschman shares his experiences and findings, detailing the characteristics of these clots, their potential links to amyloid proteins, and the implications for public health. The discussion highlights the role of embalmers in uncovering medical anomalies and raises concerns about the broader health impacts of these findings. In this segment of the conversation, Dr. Sam Sigoloff and Richard Hirschman delve into the perplexing phenomenon of clot formation in both veins and arteries, particularly in the context of COVID-19. They discuss the implications of autopsy findings, the unusual presence of amyloid clots, and the potential connections to vaccines. The dialogue also touches on the role of lipid nanoparticles and the broader implications of emergency use authorization in the context of public health and safety. In this conversation, Richard Hirschman and Dr. Sam Sigoloff delve into the alarming discovery of micro-clots in blood samples, potentially linked to vaccines and COVID-19. They discuss the challenges faced in medical research, the erosion of trust in the medical system, and the ethical dilemmas surrounding the reporting of vaccine-related injuries. The dialogue emphasizes the need for further investigation into the causes of these clots and a collective call to action for the medical community and society at large.TakeawaysRichard Hirschman has documented over 200 unusual clots since 2021.The clots are unlike anything seen prior to the pandemic.Amyloid proteins are being found in these clots, raising health concerns.The presence of amyloid in the bloodstream is alarming.There is a potential link between these clots and vaccine injuries.Embalmers are observing changes in blood that are not typical post-mortem clots.The clots are dense and do not fall apart like normal clots.There is a need for further research into the nature of these clots.The conversation highlights the importance of embalmers in medical discoveries.The findings could explain various health issues being reported post-vaccination. Autopsies typically focus on organ examination, not detailed vascular analysis.Clots are usually found in veins, not arteries, raising concerns about new findings.The presence of amyloid in clots suggests a significant change in clot composition post-COVID.Vaccine-induced thrombotic thrombocytopenia is a rare but concerning phenomenon.Lipid nanoparticles may play a role in abnormal clotting mechanisms.Emergency use authorization was declared amidst a perceived attack on public health.The presence of amyloid-like structures in blood raises questions about vaccine safety.Research indicates a potential link between spike proteins and abnormal clotting.The discussion highlights the need for further investigation into vaccine-related health issues.The conversation emphasizes the importance of transparency in medical research and public health policies. There is a significant presence of micro-clots in blood samples.Micro-clots may be linked to a new blood-borne amyloid clotting syndrome.Observation and documentation are crucial in identifying unusual medical phenomena.Medical research faces challenges in funding and peer review processes.Trust in the medical system has been severely impacted by COVID-19 protocols.The correlation between vaccines and abnormal clots is a growing concern.Ethical dilemmas arise when reporting potential vaccine injuries.Not everyone experiences the same reactions to vaccines, but harm does occur.A spiritual perspective is essential in addressing the current health crisis.Community leaders must advocate for truth and transparency in medical practices.lf you like my t-shirt please get one here:
XL
https://www.ebay.com/itm/166498979030?mkcid=16&mkevt=1&mkrid=711-127632-2357-0&ssspo=p4ex0znwsqu&sssrc=4429486&ssuid=p4ex0znwsqu&var=&widget_ver=artemis&media=COPYLarge
https://www.ebay.com/itm/166498976051?mkcid=16&mkevt=1&mkrid=711-127632-2357-0&ssspo=p4ex0znwsqu&sssrc=4429486&ssuid=p4ex0znwsqu&var=&widget_ver=artemis&media=COPYMedium
https://www.ebay.com/itm/166498969796?mkcid=16&mkevt=1&mkrid=711-127632-2357-0&ssspo=p4ex0znwsqu&sssrc=4429486&ssuid=p4ex0znwsqu&var=&widget_ver=artemis&media=COPYSmall
https://www.ebay.com/itm/166498972939?mkcid=16&mkevt=1&mkrid=711-127632-2357-0&ssspo=p4ex0znwsqu&sssrc=4429486&ssuid=p4ex0znwsqu&var=&widget_ver=artemis&media=COPYIf you would like to purchase better than grass fed and grass finished beef that will never get mRNA injections, never get growth hormones and never get antibiotics check out mycleanbeef.com/afterhoursAs always please like, share and follow. Please check out my Patreon account (https://www.patreon.com/Afterhourswithdrsigoloff). This is mostly to help with the legal fees. Please consider contributing but if you are unable to donate money please give prayers.truthforhealth.org for COVID illness and long haulers syndrome treatment protocols. If you have a vaccine injury (from any vaccine or have any injury that you think may have any relation to any vaccine) please report in their civilian equivalent to VAERS.Patreon: https://www.patreon.com/Afterhourswithdrsigoloff 
Email: afterhours@1791.com
Instagram: @afterhourswithdrsigoloff
Clouthub: @DrSigoloff
TruthSocial: @DrSigoloff
Rumble: https://rumble.com/c/AfterHoursWithDrSigoloff
Youtube: https://www.youtube.com/channel/UCQ_ng3WYVhnctCYq6Rom07g
Givesendgo: https://www.givesendgo.com/G37EN

Doctor Warrick
EP366: LDL is a Remnant or a Waste Product of Lipid Metabolism

Doctor Warrick

Play Episode Listen Later Dec 28, 2024 11:02


Welcome to my podcast. I am Doctor Warrick Bishop, and I want to help you to live as well as possible for as long as possible. I'm a practising cardiologist, best-selling author, keynote speaker, and the creator of The Healthy Heart Network. I have over 20 years as a specialist cardiologist and a private practice of over 10,000 patients. In this podcast, Dr. Warrick Bishop discusses the movement of lipids and lipoprotein particles in the body, emphasizing their role in delivering energy sources. He explains that dietary fats absorbed in the gut form chylomicrons, which enter the bloodstream and release triglycerides to tissues via the enzyme lipoprotein lipase. As triglycerides are removed, these particles become denser and transform into intermediate and low-density lipoproteins (IDL and LDL), which are remnants of energy delivery. The liver produces very low-density lipoproteins (VLDL) to perform a similar function.

Couch Talk w/ Dr. Anna Cabeca
World Menopause Day Lives Part 2

Couch Talk w/ Dr. Anna Cabeca

Play Episode Listen Later Dec 20, 2024 67:00


Menopause is one of those things no one really prepares you for, right? The sleepless nights, the cravings, the mood swings—it can feel like your body is running the show. That's why I sat down with two brilliant women, Cynthia Thurlow, a Functional Nutrition expert with over 15 million views on her TEDx talk about intermittent fasting, and Dani Williamson, a powerhouse in Integrative Medicine specializing in gut, thyroid, and hormone health, to talk about real, practical ways to make this phase of life not just manageable but empowering. From hormones to heart health to inflammation, they're sharing the stuff every woman needs to know to feel like herself again—maybe even better.   We chat about everything from creating a distraction-free sleep sanctuary to tackling inflammation and dialing in your hormones. These simple changes can make a huge difference, and you don't have to go through it alone—we're figuring it out together.   Cynthia breaks down the numbers every woman should know to protect her heart health (yes, it's about more than cholesterol), while Dani talks about the surprising ways stress wreaks havoc on your hormones. We're also getting into the hidden role of inflammation in menopause and how your diet and lifestyle choices can either fuel the fire or calm things down. Plus, there's an eye-opening conversation about setting boundaries to create space for what really matters—your health and happiness. Trust me, you'll leave this episode feeling inspired and ready to take charge!   If you're ready to feel your best, let's do this together! My Keto-Green 16 Challenge is coming up, and it's designed to help you reset after the holidays. Whether it's cravings, stress, or just needing a fresh start, this 16-day journey can boost your energy, mood, and more. Head over to dranna.com/challenge to join me—we're in this together!     Key Timestamps: [00:02:00] World Menopause Day series. [00:07:07] Inflammation and hormone imbalance. [00:10:22] Diet will heal or kill. [00:11:34] Alcohol as a sleep disruptor. [00:14:14] Bedroom sanctuary for menopause. [00:19:24] Menopause and its liberation. [00:21:48] EMF exposure and health risks. [00:26:34] The happiness hormone: pregnenolone. [00:30:10] Automate, eliminate, and delegate. [00:34:38] Women's heart health and menopause. [00:39:14] Insulin and triglyceride levels. [00:46:27] Lipid changes post-menopause. [00:51:48] Coronary artery calcification assessment. [00:53:39] Statins and heart health testing. [01:02:14] Low hormones and heart health. [01:03:17] Holiday heart and stroke risk. [01:06:18] Transforming your health journey.     Memorable Quotes: "Your diet will heal you or kill you. It is as simple as that. There is no in-between. And when you take the emotion out of food—which is what I have learned—you've just got to take the emotion out of it, and you've got to eat to live, not live to eat." [00:10:15] – Dani Williamson "Statistically, women are most likely to die from heart disease. That's why this conversation is so important. And certainly, we live longer than men... but if we don't take care of ourselves—you know, we are the caretakers for everyone else—if we are not taking care of ourselves, we are going to end up having a lower quality of life as we get older." [00:37:56] – Cynthia Thurlow     Links Mentioned: Keto-Green 16 Challenge: https://dranna.com/challenge Prevencio Tests: https://prevenciomed.com/   Connect with Dani Williamson: Website: https://daniwilliamson.com/ Instagram: https://www.instagram.com/daniwilliamsonwellness/ Facebook: https://www.facebook.com/DaniWilliamson YouTube: https://www.youtube.com/@DaniWilliamsonWellness TikTok: https://www.tiktok.com/@daniwilliamsonwellness   Connect with Cynthia Thurlow: Website: https://www.cynthiathurlow.com/ Instagram: https://www.instagram.com/cynthia_thurlow_/ Facebook: https://www.facebook.com/CHTWellness X/Twitter: https://x.com/_CynthiaThurlow TikTok: https://www.tiktok.com/@cynthia_thurlow_ Apple Podcast: Everyday Wellness with Cynthia Thurlow Spotify Podcast: Everyday Wellness with Cynthia Thurlow   Connect with Dr. Anna Cabeca: Website: https://drannacabeca.com/pages/show Instagram: https://www.instagram.com/thegirlfrienddoctor/ YouTube: https://www.youtube.com/@thegirlfrienddoctor TikTok: https://www.tiktok.com/@drannacabeca   Produced by Evolved Podcasting: www.evolvedpodcasting.com

Happily Hormonal
E177: Will DUTCH Hormone Testing Help Your PMS/PMDD Symptoms? Progesterone, GABA, Estrogen, and Cyclical Mood Changes with Dr Kelly Ruef

Happily Hormonal

Play Episode Listen Later Dec 16, 2024 33:31


Send us a textIn this episode, we discuss PMS (Premenstrual Syndrome) and PMDD (Premenstrual Dysphoric Disorder), along with the impact of hormonal imbalances on mood, energy, and overall well-being. I am joined by Dr. Kelly Ruef from Dutch, a naturopathic physician with a strong interest in biochemistry, biochemical pathways, and natural hormone pathways. She will explain how tools like the Dutch Test can help uncover what is happening beneath the surface and provide steps you can take to feel better.What You'll Learn in This Episode: -  The Role of Hormonal Fluctuations in PMS and PMDD*     We dive into why some women experience extreme symptoms during the luteal phase and the role hormones like progesterone and estrogen play in mood regulation. - The Connection Between Progesterone and GABA  Dr. Kelly explains how progesterone and its metabolites impact GABA, an inhibitory neurotransmitter that helps regulate anxiety, irritability, and sleep. We explore why low progesterone—or how your body processes it can lead to anxiety, irritability, and poor sleep. - Understanding Estrogen Dominance  Ever feel overly emotional, get headaches, or have heavy periods? These can all be signs of too much estrogen relative to progesterone. We also discuss how the balance between estrogen and progesterone plays a critical role. - The Paradoxical GABA Response  Dr. Kelly uncovers the phenomenon where some women experience increased anxiety and irritability during their luteal phase due to a paradoxical response to progesterone metabolites. - Why the Dutch Test is a Game Changer     Learn how this advanced hormone test provides a full picture of your hormonal health, helping uncover the root cause of your symptoms. - Cholesterol, Lipids, and Estrogen   Explore the surprising link between estrogen and lipid health and why low estrogen can affect cholesterol levels. Quick Tip:  Simple lifestyle changes, like getting better sleep, managing stress, and stabilizing blood sugar are powerful first steps to better hormonal health before diving into more advanced protocols. Connect with Dr Kelly Ruef on InstagramLET ME HELP YOU FIX THOSE HORMONES:FREE RESOURCESLove Your Liver GuideHormone Imbalance QuizCOURSE + COACHING (When you're ready to fix your hormones without the drama of figuring it out on your own)Disclaimer: Nothing in this podcast is to be taken as medical advice, please take informed accountability and speak to your provider before making changes to your health routine.This podcast is for women and moms to learn how to balance hormones naturally, to have better periods, increased fertility, to decrease PMS mood swings, and to increase energy without restrictive diet plans. You'll learn how to balance blood sugar, increase progesterone naturally, understand the root cause of estrogen dominance, irregular periods, PCOS, insulin resistance, hormonal acne, post birth-control syndrome, and conceive naturally. If you listen to any of the following shows, we're sure you'll like ours too! Pursuit of Wellness with Mari Llewellyn, Culture Apothecary with Alex Clark, Found My Fitness with Rhonda Patrick, Just Ingredients Podcast, Wellness Mama, The Dr Josh Axe Show, Are You Menstrual Podcast, The Model Health Show, Grounded Wellness By Primally Pure, Be Well By Kelly Leveque, The Freely Rooted Podcast with Kori Meloy, Simple Farmhouse Life with Lisa Bass

Real Science Exchange
The Dual Essentiality of Choline and Methionine with Dr. Heather White, University of Wisconsin-Madison

Real Science Exchange

Play Episode Listen Later Dec 3, 2024 45:53


This Real Science Exchange episode was recorded during a webinar, which was part of a series. Watch all the presentations from this series here: https://balchem.com/animal-nutrition-health/resources-categories/real-science-lecture-series/previous-lectures/page/10/Early in lactation, the cow is incapable of eating enough to meet her dramatically increased requirements. As the cow's intake decreases near calving, there are fewer nutrient contributions from dry matter intake and she must alter nutrient partitioning to meet her increased needs by mobilizing fat and muscle stores. (1:18)Triglycerides from fat stores are broken down into non-esterified fatty acids (NEFA) and glycerol. NEFA has two different fates in the postpartum cow: to the mammary gland as a precursor for milk fat synthesis, or to the liver to be oxidized for energy production. Glycerol enters the gluconeogenic pathway in the liver as a glucose precursor. (4:41)The capacity for the liver to use NEFA for energy is limited by the capacity of the TCA cycle. When the TCA cycle is at capacity, excess NEFA can either undergo incomplete oxidation to ketones or be repackaged back into triglycerides. If the capacity for other tissues to use ketones for energy is exceeded, then blood concentrations of ketones rise and negative outcomes from subclinical and clinical ketosis can occur. If triglycerides accumulate in the liver, negative outcomes associated with fatty liver can occur. Triglycerides can be transported out of the liver via very low-density lipoprotein (VLDL) export; however, VLDL export does not keep up with triglyceride concentration during the transition period in dairy cows, largely because of a limiting amount of phosphatidylcholine. (5:51)Dr. White describes a series of experiments in her lab using liver cells in culture to investigate the relationship between choline supplementation and VLDL export. As choline supplementation to the cell culture increased, so did VLDL export from the cells into the media. In addition, increasing choline supplementation to the cell culture also decreased cellular triglyceride content. (10:54)Using gene expression and radiolabeled tracers over a series of experiments, Dr. White's group found that as choline supplementation increased, so did complete oxidation of NEFA to energy. This was accompanied by decreased incomplete oxidation to ketone bodies and decreased accumulation of lipids in the liver cells. Glucose and glycogen were also increased with increasing choline supplementation to the cell culture, and a decrease in reactive oxygen species was observed. In addition, choline-supplemented cultures exhibited an increase in metabolic pathways associated with methionine regeneration and methyl donation. (15:29)Dr. White then details the complexity of the metabolic pathways that intersect between choline and methionine. In similar experiments supplementing cell cultures with increasing amounts of methionine and choline, there were no effects of methionine on lipid export, oxidative pathways, or glucose metabolism. The main benefit of methionine was a marked increase in glutathione production. It's important to note that no interactions between choline and methionine were observed in this series of experiments. (19:37)There seems to be a clear biological priority for different sets of pathways for choline and methionine. Choline seems to be influencing lipid, glucose, and oxidative pathways, while methionine is primarily serving its role as an essential amino acid for cellular protein structure and generation, acting as a methyl donor, and impacting inflammation. Importantly, both the choline and methionine results observed in cell culture are paralleled in transition dairy cow studies. (24:14)Dr. White's lab further investigated the impact of methionine on inflammation. When cells were challenged with LPS to provoke an inflammatory response, methionine mitigated the inflammatory response. Similar results have been observed in liver tissue samples of transition cows. Methionine mitigated inflammatory markers and increased glutathione but did not influence reactive oxygen species. Conversely, choline decreased reactive oxygen species but did not change glutathione. (27:47)Choline and methionine are both essential nutrients, there are biological priorities for them as methyl donors, and they are not mutually exchangeable. The lack of interaction between choline and methionine in vivo or in vitro supports the idea of different biological roles for these nutrients. (32:09)Dr. White takes questions from the webinar audience. (34:53)Please subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table.  If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll mail you a shirt.

Cardionerds
403. Cardio-Rheumatology: Treating Inflammation and Real-World Implementation of Therapies with Dr. Brittany Weber and Dr. Michael Garshick

Cardionerds

Play Episode Listen Later Nov 14, 2024 36:39


In this episode, CardioNerds Dr. Gurleen Kaur and Dr. Akiva Rosenzveig are joined by Cardio-Rheumatology experts, Dr. Brittany Weber and Dr. Michael Garshick to discuss treating inflammation, delving into the pathophysiology behind the inflammatory hypothesis of atherosclerotic cardiovascular disease and the evolving data on anti-inflammatory therapies for reducing ASCVD risk, with insights on real-world implementation. Show notes were drafted by. Dr. Akiva Rosenzveig. This episode was produced in collaboration with the American Society of Preventive Cardiology (ASPC) with independent medical education grant support from Lexicon Pharmaceuticals. CardioNerds Prevention PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls - Treating Inflammation Our understanding of the pathophysiology of atherosclerosis has undergone a few iterations from the incrustation hypothesis to the lipid hypothesis to the response-to-injury hypothesis and culminating with our current understanding of the inflammation hypothesis. Both the adaptive and innate immune systems play instrumental roles in the pathogenesis of atherosclerosis. After adequately controlling classic modifiable risk factors such as blood pressure, dyslipidemia, glucose intolerance, and obesity, systemic inflammation as assessed by CRP can be ascertained as CRP is associated with ~1.8-fold increased risk of cardiovascular events Although the most common side effect of colchicine is gastrointestinal intolerance, colchicine can induce lactose intolerance, so a lactose free diet may help ameliorate colchicine-induced GI symptoms. Anti-inflammatory therapeutics have shown promise in reducing cardiovascular risk but much more is to be learned with ongoing and future basic, translational, and clinical research. Show notes - Treating Inflammation What are the origins of the inflammatory hypothesis? The first hypothesis as to the pathogenesis of atherosclerosis was the incrustation hypothesis by Carl Von Rokitansky in 1852. He suggested that atherosclerosis begins in the intima with thrombus deposition.In 1856, Rudolf Virchow suggested the lipid hypothesis whereby high levels of cholesterol in the blood lead to atherosclerosis. He observed inflammatory changes in the arterial walls associated with atherosclerotic plaque growth, called endo-arteritis chronica deformans.In 1977, Russell Ross suggested the response-to-injury hypothesis, that atherosclerosis develops from injury to the arterial wall.In the 1990's the role of inflammation in ASCVD became more recognized. Both the adaptive and innate immune system are critical in atherosclerosis. Lipids and inflammation are synergistic in that lipid exposure is required but they translocate through damaged endothelium which occurs by way of inflammatory cytokines, namely within the NLRP3 inflammasome (IL-1, IL-6 etc.).Smooth muscle cells are also involved. They migrate to the endothelial region and secrete collagen to create the fibrous cap. They can also transform into macrophage-like cells to take up lipids and become foam cells. T, B, and K cells are also part of this milieu. In fact, neutrophils, macrophages and monocytes make up only a small portion of the cells involved in the atherosclerotic process. What are ways to individually optimize one's ASCVD risk?Ensure the patient is on appropriate antiplatelet therapy, lipid lowering therapy, blood pressure is well controlled, and the Hemoglobin A1c is well controlled. Smoking cessation is pivotal.If the patient has an elevated Lipoprotein (a), pursue more aggressive lipid lowering therapy. Targeted therapies may become available in the future. Assess the patient's systemic inflammatory risk as measured by C-Reactive Protein (CRP)