Podcasts about lipids

Send us a textImagine a healthcare experience where your doctor truly knows you, your concerns aren't rushed, and your wellness plan is as unique as you are. That's the heart of Concierge Medicine—a personalized, proactive approach that puts the focus back where it belongs: on you.In this episode taken from The Optispan Podcast with Dr. Matt Kaeberlein, we explore how deeper doctor-patient relationships, cutting-edge diagnostics, and tailored care are redefining what it means to stay healthy.What you'll learn:More time, more care – How longer, unrushed visits lead to better health outcomesBeyond the basics – The advanced tests and tools that provide a clearer picture of your well-being Surprisingly accessible – Why Concierge Medicine isn't just for the ultra-wealthy Designed for your lifestyle – From athletes to longevity seekers, how personalized care fits your needs 

Send us a textCardiologist Dr. Michael Koren joins Kevin Geddings to discuss progress in the world of cholesterol management. Dr. Koren explains the importance of getting cholesterol - especially LDL cholesterol - under control and the potential benefits to heart attack and stroke risk. They discuss some of the problems with current therapies; they are highly effective but can introduce burdens to patients with the back-and-forth for multiple medications. Dr. Koren then reveals new medicatiosn being studied which may combine multiple cholesterol medications into a single pill, reducing barriers and  potentially improving outcomes.Be a part of advancing science by participating in clinical research.Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.comListen on SpotifyListen on Apple PodcastsWatch on YouTubeShare with a friend. Rate, Review, and Subscribe to the MedEvidence! podcast to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramX (Formerly Twitter)LinkedInWant to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.comMusic: Storyblocks - Corporate InspiredThank you for listening!

The guys come together this month to discuss heart health, lipids, and mitigating the risks that come with bodybuilding.We aimed to be helpful and not to science-y so everyone can understand what we discussed today. We cover - risk factors to pay attention to, tests and scans to run, supplements to keep year round for heart and lipid health, and more."The Sensible Solutions Coaching Podcast" is raw, real, direct, applicable, and empathetic fitness coaching advisory - we aim to cut through the complexity and madness with free knowledge to help coaches, clients, and all fitness enthusiasts keep progress simple.It is the ONLY podcast you'll need to think, learn, laugh, and level up!If you learned something from this podcast episode, please leave us some stars, a review, or share us with a client or coaching friend.Happy coaching!@beoppositetraining @austinst8 @firstcalloutfitness @ericalper_firstcalloutfitness

Q-BANK: https://patreon.com/highyieldfamilymedicineIntro 0:35,Dyslipidemias 1:48,Statins 4:24,Statin side effects 6:22,Non-statin lipid lowering medications 8:17,Familial Hypercholesterolemia 11:45,Obesity 12:52,Weight loss medications 15:25,Bariatric surgery 19:04,Practice questions 22:19,

Curious about lipids? Do you know what to do with LPa and ApoB?Listen in this week as host Karli Burridge speaks with Josh Wageman, author of the newly released book titled: "The Home Security System and the Lipid Neighborhood: Un-Complicating Cholesterol and Cardiovascular Disease"It sounds like the start of a bad joke…or perhaps a confusingly awesome dream. A Physical Therapist, ex-collegiate track athlete, Ivy league grad, Youth Pastor, and some dude with a PhD start having a conversation about cholesterol. And then you realize all those guys are THE SAME GUY, and that guy takes you on a whimsical pilgrimage that results in YOU having a framework for NOT having heart attacks, strokes, and dementia. Employing a smorgasbord of metaphors, pictures, and catchphrases, The Home Security System and the Lipid Neighborhood serves as a valuable reference for clinicians and non-clinicians alike, bringing refreshing relatability to complex biochemical topics. Through a lipid-lens, you'll learn, laugh, and love your way through its pages…and in the end, you'll undoubtedly add “life to your years!”Available at: https://www.amazon.com/dp/B0DR33FPZF?ref_=pe_93986420_775043100On X: https://x.com/joshjwagemanInstagram Tag is @wagemanjosh and you're welcome to find Josh on LinkedIn and FacebookSupport the showThe Gaining Health Podcast will release a new episode monthly, every second or third Wednesday of the month. Episodes including interviews with obesity experts as well as scientific updates and new guidelines for the management of obesity.If you're a clinician or organization looking to start or optimize an obesity management program, and you want additional support and resources, check out the Gaining Health website! We offer a Roadmap to starting an obesity program or practice, pre-recorded Master Classes, digital resources including patient education materials and office forms, and much more! Check out our resources on our Gaining Health Shop! If you are loving this podcast, please consider supporting us on Patreon

CardioNerds co-founders Dr. Daniel Ambinder and Dr. Amit Goyal are joined by Dr. Spencer Weintraub, Chief Resident of Internal Medicine at Northwell Health, Dr. Michael Albosta, third-year Internal Medicine resident at the University of Miami, and Anna Biggins, Registered Dietitian Nutritionist at the Georgia Heart Institute. Expert commentary is provided by Dr. Zahid Ahmad, Associate Professor in the Division of Endocrinology at the University of Texas Southwestern. Together, they discuss a fascinating case involving a patient with a new diagnosis of hypertriglyceridemia. Episode audio was edited by CardioNerds Intern Student Dr. Pacey Wetstein. A woman in her 30s with type 2 diabetes, HIV, and polycystic ovarian syndrome presented with one day of sharp epigastric pain, non-bloody vomiting, and a new lower extremity rash. She was diagnosed with hypertriglyceridemia-induced pancreatitis, necessitating insulin infusion and plasmapheresis.   The CardioNerds discuss the pathophysiology of hypertriglyceridemia-induced pancreatitis, potential organic and iatrogenic causes, and the cardiovascular implications of triglyceride disorders. We explore differential diagnoses for cardiac and non-cardiac causes of epigastric pain, review acute and long-term management of hypertriglyceridemia, and discuss strategies for the management of the chylomicronemia syndrome, focusing on lifestyle changes and pharmacotherapy.  This episode is part of a case reports series developed in collaboration with the National Lipid Association and their Lipid Scholarship Program, with mentorship from Dr. Daniel Soffer and Dr. Eugenia Gianos. US Cardiology Review is now the official journal of CardioNerds! Submit your manuscript here. CardioNerds Case Reports PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls - Hypertriglyceridemia Cardiac sarcoidosis can present with a variety of symptoms, including arrhythmias, heart block, heart failure, or sudden cardiac death. The acute management of hypertriglyceridemia-induced pancreatitis involves prompt recognition and initiation of therapy to lower triglyceride levels using either plasmapheresis or intravenous insulin infusion +/- heparin infusion. Insulin infusion is used more commonly, while plasmapheresis is preferred in pregnancy.   Medications such as fibrates and omega-3 fatty acids can be used to maintain long-term triglyceride reduction to prevent the recurrence of pancreatitis, especially in patients with persistent triglyceride elevation despite lifestyle modifications. Statins can be used in patients for ASCVD reduction in patients with a 10-year ASCVD risk > 5%, age > 40 years old, and diabetes or diabetes with end-organ damage or known atherosclerosis. Consider preferential use of icosapent ethyl as an omega-3 fatty acid for triglyceride lowering if the patients fit the populations that appeared to benefit in the REDUCE IT trial.   Apply targeted dietary interventions within the context of an overall healthy dietary pattern, such as a Mediterranean or DASH diet. Limit full-fat dairy, fatty meats, refined starches, added sugars, and alcohol. Encourage high-fiber vegetables, whole fruits, low-fat or fat-free dairy, plant proteins, lean poultry, and fish. Pay special attention to the cooking oils to ensure the patient is not using palm oil, coconut oil, or butter when cooking. Instead, use liquid non-tropical plant oils. Initiate a very low-fat diet (< 5% of total daily calories from fat) for 1-4 weeks when TG levels are > 750 mg/dL.  Recommend and encourage patients to exercise regularly, with a minimum goal of 150 minutes/week of moderate-intensity aerobic activity. If weight loss is required, aim for more than >225 - 250 minutes/week.   Develop patient-centered and multidisciplinary stra...

Send us a textShort Summary: How dietary fructose affects the growth rate of cancer.About the guest: Gary Patti, PhD is a professor at Washington University in St. Louis, holding appointments in chemistry, medicine, and geneticsNote: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere. Full transcript and other information on Substack.Episode Summary: Nick Jikomes talks to Dr. Patti, exploring how cancer cells metabolize sugars like glucose and fructose, focusing on a recent study showing fructose indirectly boosts tumor growth in mice via liver-produced lipids called LPCs. The discussion covers cancer biology basics, Warburg effect, tumor microenvironments, and systemic metabolic impacts of cancer, while also touching on dietary implications, fasting, and the complexities of nutrient use in cancer progression.Key Takeaways:Cancer cells often rely heavily on glucose, excreting it as lactate even when oxygen is available (Warburg effect), but take up more than their mitochondria can handle.In a study, high fructose diets accelerated tumor growth in mice by 4x, not because cancer cells use fructose directly, but because the liver converts it to LPCs, which tumors use to build membranes.Tumors are not just cancer cells; they recruit healthy cells in their microenvironment, and their metabolic effects ripple across the entire body, altering distant tissues.Excessive fructose consumption may worsen tumor growth, but cutting it poses little risk and could benefit cancer patients, pending human studies.Fasting may reduce cancer initiation risk in animals, but its effect on existing tumors is less clear and could worsen wasting (cachexia) in late stages.The body tightly regulates blood glucose via the liver, so simply cutting dietary glucose won't starve tumors, highlighting cancer's metabolic adaptability.Related episode:M&M #200: Dietary Fats & Seed Oils in Inflammation, Colon CancerSupport the showAll episodes, show notes, transcripts, etc. at the M&M Substack Affiliates: Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Readwise: Organize and share what you read. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. KetoCitra—Ketone body BHB + potassium, calcium & magnesium, formulated with kidney health in mind. Use code MIND20 for 20% off any subscription. MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils or artificial ingredients. Use code MIND for 20% off. For all the ways you can support my efforts

Ready to reverse your chronic disease? Dr. Ford and the PrevMed staff are currently accepting new patients for a limited time. Book an appointment here: https://prevmedhealth.com/To ensure quality of care there are limited openings available so act quickly.

 You've gone to the doctor and had your cholesterol checked, but what do all those numbers mean? And is there anything you can do to lower your cholesterol without medications? I'm so glad you asked.  I'm Dr.Vickie Petz Kasper. If you're ready to take control of your health, you're in the right  place. Whether you're focused on prevention or you're trying to manage a condition. I'll give you practical steps to start your own journey toward better health because healthy looks great on you.  This is episode 1 64. Cholesterol, the Good versus the Bad. When I was about 26 years old, I had my cholesterol checked for the first time. Imagine my surprise when the number was 256.  Yikes. Now admittedly, the hospital where I was doing my residency had a fast food restaurant conveniently located right there in the cafeteria and my go-to: hamburgers and french fries. But also I have a strong family history of significantly elevated cholesterol.  The doctor said I could lower it some and I should diet and exercise and blah, blah, blah, blah, blah, blah, blah. But guess what? I eventually lowered my cholesterol to 156 without medication, and I'm going to tell you how you can do it too. But first, let's start at the beginning and go to mini medical school and learn exactly what is cholesterol. Technically we call it a lipid, which is sort of like a fat that circulates in your bloodstream. Structurally, these compounds make up parts of cell membranes and functionally they help regulate the transport across these membranes, so that's good. Right? Well, yes, we do need cholesterol to help move and store energy, produce hormones, and absorb vitamins. But you know, too much of a good thing. We'll get to that. Lipids don't dissolve in water, so they have to hitch a ride on proteins to travel through the blood, and when they get hitched, they change their name to lipoproteins. Now this is gonna sound familiar if you've ever had a lipid panel drawn.  HDL stands for high density lipoproteins and LDL stands for low density lipoproteins.  Where does it come from? Well, your body actually makes it in both the liver and small intestines. Then it's stored in the liver where it's converted to bile acids, so you can get rid of it. Is it bad or good? Well, that depends. HDL cholesterol reduces inflammation, prevents blood clots, and helps transport oxygen. And your body makes all of it that you need all of it. But here's the deal. Not only does your body make cholesterol, but we also eat it. Most of the cholesterol in the standard American diet comes from meat, eggs, cheese, and dairy products. Oh, well, who can afford eggs anyway? But seriously, cholesterol is sneaky. Rather than announcing its presence, it just slips through your blood vessels undetected, but it leaves a calling card and we call it plaque. This buildup in the wall of the arteries can lead to hardening of the arteries and therefore cardiovascular disease. Think about it. If a plaque gets big enough, it can compromise blood flow and cause a heart attack or stroke. And this can also happen with smaller plaques when a piece breaks off. I told you cholesterol is sneaky. Most people who have high cholesterol have no symptoms. We call it hyperlipidemia, and that's why you need to know your numbers and you need to know what they mean.  I guess all those burgers weren't helping me have healthy blood vessels when I was in my twenties.  But that's not the whole story. We could go to mini medical school and learn the difference between HDL and LDL cholesterol, or we could just call them good cop, bad cop. Because that kind of sums it up. The reason LDL cholesterol is the bad cop is because it causes a fatty buildup inside the arteries and that impairs blood flow and puts you at increased risk of a heart attack or stroke. You've seen those detective shows where they lock someone in an interrogation room and they just yell at 'em. No, it's not exactly the same, but I bet you'll remember now that LDL the bad cop cholesterol can make you have a heart attack. Now the good cop HDL cholesterol can actually lower your risk of heart disease and stroke. You know, it's the reassuring I'll be your friend cop. Picture the scene, bad cop is giving the suspect a really hard time and good cop comes in and sends the bad cop away.   Stick with me here. HDL, good cholesterol carries at least a little bit of the LDL or bad cholesterol out of the arteries where it causes damage and into the liver where it can be broken down and eliminated. So speaking in very general terms, you want your HDL cholesterol to be high and your LDL cholesterol to be low. We'll get to specific numbers in a sec. I do want to mention triglycerides. They are not the same thing as cholesterol, but they hang out together because you know, birds of a feather... When you have a lipid panel done, they often measure the whole flock, total cholesterol, HDL cholesterol, LDL, cholesterol and triglycerides. You've also probably heard about the ratio and yes, it's very important, but whose side are these triglycerides on anyway? Well, they're the most common type of FAT in the body. And like all things in our bodies, they have a purpose and that is to store excess energy from your diet. And yeah, that's the problem. Most of us have plenty of excess in our diet.  Hamburgers and french fries, or as Steve Martin said in the old Pink Panther movie, "Am barger." If you don't know that scene and that didn't make you laugh, please google it and watch a clip.  The bottom line is that high triglycerides combined with high LDL means fatty buildup in the walls of the arteries, and that increases the risk of heart attack and stroke. Okay, I hope you're convinced that Steve Martin is hysterical and you need to see the clip from the Pink Panther, and you need to get your cholesterol checked.  You are convinced, right? Don't believe me. The American Heart Association recommends that if you are over the age of 20, you should have your cholesterol checked and depending on your risk factors, every four to six years after that, until you get older and have an increased risk of. every dang thing. So now you've had your blood drawn and the doctor calls you with your results.  No. Oh yeah. Your results are now on the portal and you want to know what they mean.  I do have to tell you that context matters and you really should discuss the results with your doctor, but if you don't hear from them, I'll give you some generalities for people who do not already have cardiovascular issues, and by the way, you should fast for at least 12 hours before you go to the lab and get this. You shouldn't have the test done if you're sick or stressed. Stress affects cholesterol too. It wreaks havoc on your body in so many ways. First of all, people who are stressed often smoke more, drink more, sleep less, exercise less socially isolate and eat more junk. So there's that, but also our old friend Cortisol, the stress hormone also plays a role. Cortisol is our body's way of preparing us to physically respond to a threat. So it triggers the release of glucose and fatty acids into the bloodstream and muscles. So energy is available for slaying dragons   threatening our safety, and that's a good thing when there are dragons pulling up in your driveway. Not so much if you live in a constant state of stress. Of course, if you have prolonged stress, you'll have to go ahead and surrender that vein in your arm and get your lipids checked anyway, because when it comes to your numbers, you need to know. So let's get to those numbers. Total cholesterol should be below 200 milligrams per deciliter, and if it's between 201 and 239, that's considered borderline high cholesterol, and if it's above 240, that's just plain over the limit. Now, LDL cholesterol should be below 130 or even much lower than that if you are at risk of heart attack or stroke, HDL should ideally be above 60 and triglycerides below 150. Any numbers outside of these parameters should be taken seriously because you have a higher risk of cardiovascular disease, especially if you continue to eat ham ba burgers.  Now, let's say you do hear from your doctor's office. You know, the nurse calls and says you either need to take a cholesterol lowering medication like a statin or that you need to eat a low cholesterol diet and exercise. Thank you very much. But shouldn't we have a more detailed conversation about this result?  You bet. Your cholesterol is just one group of numbers. It's not the whole picture. Your risk of heart disease is impacted by other factors like smoking, high blood pressure, your family history, your age, and yes, of course your diet. And we are going to talk about a heart healthy diet in a bit. But first, let's discuss that conversation you're having with the nurse who calls from the doctor's office and said, we've sent in a prescription for a statin.  Hold up a minute. This literally happened to me last year. My total cholesterol was 202, a whopping two points above the normal range, and my ratio of good cholesterol to bad cholesterol was excellent. So I questioned this recommendation,  but what are the recommendations? Remember, I am board certified in lifestyle medicine, which is a subspecialty of conventional medicine. So we're not opposed to treatment with medication when indicated, but before we go firing off prescriptions, we should at least examine the indications. If your cholesterol is abnormal, and I would argue that mine is not thanks to some serious changes in my lifestyle and not my inherited tendencies, then you may need a cholesterol medication. Depending on your age and the likelihood of developing heart disease, but if you're not at risk for heart disease, then you might not need a medication, even if your cholesterol is high. At least not for now, because here's the deal, the number of your years only increases and age is a risk factor for heart disease, which by the way, is the number one killer of Americans. So let's say you are at risk and your cholesterol is high and your doctor wants you to take a medication quick pharmacology review. These medications can help the body make less cholesterol, which is one source. They can block the absorption of cholesterol from food, which is another source, and on top of that, they can actually help your body get rid of cholesterol faster. Sounds great. Right, and it can be, you should probably take medication if you have known heart disease, especially if you've actually had a heart attack or stroke. And because diabetes is such a big risk factor for cardiovascular disease, you may need to take a medication if you have type two diabetes, even if your cholesterol isn't high. And that's to prevent heart disease. Of course, you need to discuss all of this with your personal healthcare provider, and I recommend following their advice after you've had a conversation about options and risk. The most commonly prescribed class of medications are statins, but there are others. But can you lower your cholesterol without medications? I'm living proof  exercise helps raise your good cholesterol and lower your bad cholesterol, but you gotta do it regularly. Ideally, 30 minutes, five days a week, or if you wanna step it up a notch, 20 minutes of vigorous exercise three times a week. And remember, vigorous means you cannot have a conversation if you're talking, you are not exercising vigorously. You gotta be huffing and puffing to reach this level. So if you decide to stick with moderate, you can talk, but you can't sing. But here's the beauty of exercising - every little step in the right direction has immediate benefits, so you can start small and see results. Resistance training is great to build muscle strength and burn energy. You know, bands, weights, pushups, things like that. Or maybe you could start walking briskly. Or go to the gym and join a class for built-in accountability and social connections.   Let me give you a startling fact.  People who have a heart attack are four times more likely to die within three years if they don't have social connections. The older you get, the stronger the association. And if you're wondering how in the world that could be, it turns out the key is caring about others. When you value people in your life and you know they value you, you are more likely to make healthier choices like not smoking and positive relationships help manage stress and lower inflammation, and that damages blood vessels and also contributes to heart disease.  Sleep matters too. As part of an overall healthy lifestyle, you should aim for seven to nine hours per night and less than six hours a night is associated with higher cholesterol levels.  In the past, medical literature reported a positive association between drinking a glass of red wine and heart health. Turns out that's probably not true and moderate to heavy drinking  unquestionably raises your risk for heart disease. You know, if your liver's working overtime to get rid of alcohol, it's much less effective in dealing with cholesterol. Now, your Dr. may not have mentioned any of this except diet and exercise. So let's park there for a minute. A healthy weight is often associated with better numbers, but that isn't always true. Genetics also plays a big role, but whether you're at an ideal weight or overweight, changing your diet can have a huge impact on your cholesterol. In fact, depending on how much change you're willing to make, I would say that you can lower your cholesterol to a healthy level. And if you're interested in making healthy habit changes, you might want to go to my website Healthy Looks Great on you.com and sign up for Kickstart to Better Health. And for sure, you're going to want to stay tuned for an upcoming interview I have on Habit Change. Subscribe to this podcast. There's a link in the show notes or go to the website Healthy looks great on you.com. Either way, you should listen to your doctor. And make sure they listen to you as well. You may need medication to lower your cholesterol, and you may need to make lifestyle changes, especially if your numbers are going up in the wrong direction, even a little. But if you're motivated to do it without medications, let me harp on your diet. Hear me when I say this. When it comes to cholesterol or weight loss, diet matters more than exercise. Of course you should do both, but if you don't change your diet, exercise may not have the impact you're looking for. If you want to reduce the intake of cholesterol, stay away from trans fats, sometimes referred to as partially hydrogenated oils. They've basically been outlawed and banned anyway, but sometimes these transitions take some time to implement. Just make sure packaged pastries and things like margarine, which you shouldn't be eating anyway, don't have them. Avoid foods that are high in any kind of saturated fat.   Here's my top five list of foods that are high in cholesterol. Maybe we can find some hints about why my cholesterol was high eating in that fast food restaurant every day. Number one is red meat, beef, pork,  and especially processed meats like bacon, sausage, and hot dogs. Ah, remember what those hamburgers did to my cholesterol numbers. Number two is fried foods, and yes, I ordered french fries with my burgers. And fried foods are particularly bad when certain oils are used. Number three is sugar sweetened beverages and good grief. I drank a Coke with my burger and fries. No wonder my numbers were bad. Number four is sweets, pastries, pies, cakes, cookies, and ice cream. Yep. I probably ate that too. Number five is dairy, especially whole milk, cream, butter, and unfortunately cheese, which I also put on my burger. Good grief. I was daring my cholesterol to be high with all the foods from the naughty list. So what am I doing now? Well, I'm glad you asked. Here's a fun fact.  You really don't find cholesterol in plants. So eat plants, eat a lot of plants, eat different plants, eat plants that have different colors. Usually the darker, brighter the color, the more nutrients it has. Cholesterol's only found in processed foods, meat and dairy. But you wanna know what's only found in plants. Fiber and a high fiber diet is so important in lowering your cholesterol. It creates a healthy gut microbiome. Think of it like a sponge too, that soaks up cholesterol out of your bloodstream and helps remove it. Things like unprocessed oatmeal, whole wheat bread, whole grain brown rice, and popcorn. Also, beans, broccoli, sweet potatoes, apples, pears, oranges, grapes, all kinds of berries and nuts are on the good list. You didn't just ask me about eggs, did you? Goodness, that's a whole other conversation. And so is the other player in this conversation, triglycerides. But I will tell you that if you have high LDL cholesterol, you should at least limit your consumption of eggs. And the bottom line is that HDL cholesterol is your friend. It can help protect you from cardiovascular disease. And LDL Cholesterol levels should be low for heart health. That's easy to remember. H stands for high. L stands for low, and in some cases your doctor will want it really, really low. Below 70. So is cholesterol good or bad? The answer is yes. Cholesterol helps with cell membrane transport, absorption of vitamins, brain function, hormone production. But don't get the wrong idea. LDL cholesterol causes fatty buildup in the arteries, and that can be a huge threat to your health. So lower your bad cholesterol with medications if you need it, but definitely lower it with lifestyle changes because lower LDL is better for your health and healthy. Looks great on you.    The information contained in this podcast is for educational purposes only and is not considered to be a substitute for medical advice. You should continue to follow up with your physician or health care provider and take medication as prescribed. Though the information in this podcast is evidence based, new research may develop and recommendations may change 

In this podcast, expert clinicians will discuss the role of lipoprotein(a) [Lp(a)] in atherogenesis and emerging therapies that reduce Lp(a). To claim CE credit after listening to this episode, go to this link and check the "Already listened on another platform?" box: https://healio.com/cme/mededtalks/cardiology/20250303/5-lipid-legends-with-your-host-dr-ronald-codario

Garth wants to know, given the skin can block water from passing through it, how do certain skin creams allege to permeate into our body? James Tytko took on the question with help from Richard Guy, Professor of Pharmaceutical Sciences at the University of Bath... Like this podcast? Please help us by supporting the Naked Scientists

Marilyne est physicienne et dirige le laboratoire de performances intégrées au design (LIPID) à l'EPFL qui travaille sur les technologies durables de la construction, en particulier l'apport de lumière naturelle dans les bâtiments. Abordée dans un premier temps sous l'aspect purement optique, elle explore aujourd'hui une approche psychophysiologique de la lumière sur les humains. Un parcours qui mélange avec audace la science et l'expérience sensible pour rallier les énergies autour de projets éthiques et novateurs.Le conseil lecture de Marilyne :Nexus : Une brève histoire des réseaux d'information, de l'âge de pierre à l'IA, Yuval Noah Harari, 2024Propos recueillis par Dimitri Kasparian et Cyril VeillonProduction: Archizoom / Communication: Solène Hoffmann / Direction artistique et montage: Marie Geiser / Jingle et musique: Cédric Liardet

Under John Krzywicki's leadership, US-based biotech company Checkerspot will refine its focus on using microalgae and precision fermentation to develop sustainable high value triglyceride fats and oils not easily sourced from nature at commercially relevant scale and cost

0:00- Intro1:00- CGM and Peter Attia's recommendations11:00- Lipids. LDL, ApoB24:00- Hedonic eating31:00- Our super power to manipulate weight33:00- Health ramifications of excess junk food37:00- Exercise “snacks” and intermittent exercising40:00- Levels of enjoyment from food49:00- Hunger and appetite55:30- Calorie cycling59:30- What it takes to maintain peak physique and performance1:01:00- Low volume training1:20:00- Aaron's PED update

In this podcast, expert clinicians will assess the latest understanding regarding homozygous and heterozygous familial hypercholesterolemia (FH), risk assessment, and options for management. To claim CE credit after listening to this episode, go to this link and check the "Already listened on another platform?" box: https://healio.com/cme/mededtalks/cardiology/20250211/3-lipid-legends-with-your-host-dr-ronald-codario-featuring-dr-james-underberg Read More  

To help us unpack all the research and studies we have Dr. Stengler joining us today.In addition to authoring 30 books on health and several best-sellers such as “The Natural Physician's Healing Therapies,” “Prescription for Natural Cures,” “Prescription for Drug Alternatives,” and “Outside the Box Cancer Therapies,” Dr. Stengler has been published in several peer-reviewed medical journals such as The International Journal of Family & Community Medicine, Endocrinology & Metabolism International Journal, and Journal of Nutritional Health & Food Engineering.The newest book is called, The Holistic Guide to Gut Health. A comprehensive yet accessible approach to healing leaky gut and the many uncomfortable symptoms it causes. Dr Stengler is also the founder of The Stengler Center for Integrative Medicine.Talking Points:Palmitoylethanolamide (PEA), is a naturally occurring fatty acid derivative made in the body and found in small amounts in foods. Several human studies have demonstrated that PEA has broad-spectrum pain-relieving properties, anti-inflammatory effects, and nerve protection.PEA was first discovered in 1957 by scientists at Merck Sharp & Dohme, who isolated it from egg yolk, peanut meal, and soy lecithin. They found that PEA had anti-inflammatory properties in guinea pigs.However, PEA's role as a potential therapeutic agent was not widely recognized until 1993, when Rita Levi-Montalcini and her colleagues published research that suggested PEA has anti-inflammatory properties. Levi-Montalcini's group termed PEA an autocoid local injury antagonist (ALIA), and suggested that it acts locally to counteract injuryMultiple studies have demonstrated that PEA improves all sorts of pain. For example, a 2023 analysis of 11 studies found that PEA improved pain of various conditions, including muscle and joints, nerves, gynecological, and digestive. In terms of joint pain, a high-quality study demonstrated that PEA significantly reduced adult joint pain compared to placebo. Moreover, 8 clinical trials demonstrated that PEA was effective for low back pain, sciatica, and carpal tunnel syndrome. Even migraine headache pain was shown in published research to be improved with PEA.Lipid mediators help to balance the immune, nervous, and endocrine systems, affecting pain pathways related to inflammation. But unfortunately, due to changing diets, many of us do not get the nutrition and activity we need to make enough PEA ourselves.Supplemental PEA, by Levagen+ is properly formulated for optimal bioavailability, 75% more bioavailable to cell receptors than dietary formsLevagen+ liposomal delivery of PEA has been clinically studied and shows benefits in joint pain, nerve pain, migraine, infections, sleep, and cognitive function.Learn more about Emerald Labs PEA+ Levagen Use the code: Forever and get 20% off your order.

In this episode, Robin Riddle, FNP-C explains what a lipid panel is, what it measures, and how it is interpreted in integrative medicine.What did you think of this episode of the podcast? Let us know by leaving a review!Connect with Performance Medicine!Check out our new online vitamin store:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://performancemedicine.net/shop/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Sign up for our weekly newsletter: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://performancemedicine.net/doctors-note-sign-up/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@PMedicine⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@PerformancemedicineTN⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠YouTube: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Performance Medicine⁠

Róisin McGuigan, Commissioning Editor, Nucleic Acid Insights, speaks to Ketaki Deshmukh, Senior Scientist, Novo Nordisk, about advanced characterization tools for LNPs, challenges in extrahepatic delivery, scalability issues, and the potential impact of AI and machine learning (ML) on future LNP development.

Lipid Drugs: Part 2   Guest: Alicia A. Mickow, APRN, C.N.P., M.S.N Host: Stephen L. Kopecky, M.D.   In Part 2, we will explore potential side effects and barriers to prescribing these medications, considering various patient factors. If you missed Part 1 last week, we encourage you to listen to it first, as this episode serves as a continuation and conclusion of that discussion.   Topics Discussed: Side effects of these newer non-statin drugs Barriers to prescribing those drugs   Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices. LinkedIn: Mayo Clinic Cardiovascular Services Cardiovascular Education App: The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today! No CME credit offered for this episode. Podcast episode transcript found here.

Lipid Drugs: Part 1   Guest: Alicia A. Mickow, APRN, C.N.P., M.S.N Host: Stephen L. Kopecky, M.D.   In Part 1 of this two-part series, listeners will learn the challenges of managing patients who are statin-intolerant, the range of available treatment options, alternative dosing schedules, and strategies for introducing newer medications. Stay tuned for Part 2, where they will examine the side effects of these newer drugs and barriers to prescribing them.   Topics Discussed: What are the non-stain medications available and how are they different from statins? How do you decide which medication to use when patients are statin intolerant?   Connect with Mayo Clinic's Cardiovascular Continuing Medical Education online at https://cveducation.mayo.edu or on Twitter @MayoClinicCV and @MayoCVservices. LinkedIn: Mayo Clinic Cardiovascular Services Cardiovascular Education App: The Mayo Clinic Cardiovascular CME App is an innovative educational platform that features cardiology-focused continuing medical education wherever and whenever you need it. Use this app to access other free content and browse upcoming courses. Download it for free in Apple or Google stores today! No CME credit offered for this episode. Podcast episode transcript found here.

Dr. Tamara Ruggles:  www.linkedin.com/in/tamara-ruggles-491882251 Dr. Josh Wageman:  linkedin.com/in/josh-wageman-48893445 The Home Security System and the Lipid Neighborhood: Un-Complicating Cholesterol and Cardiovascular Disease by Dr. Josh Wageman can be found on Amazon.com beginning February 18, 2025.

For more information, visit https://thecirsgroup.com or subscribe to our newsletter to join us for our next live Q&A webinar! https://www.thecirsgroup.com/webinar CIRS, or Chronic Inflammatory Response Syndrome, is best treated with the Shoemaker Protocol. Research and clinical experience has shown that patients tolerate the protocol far better when they incorporate lipid replacement therapy. This means more supplements! But not all supplements are created equal. Today we'll cover the most often recommended lipids for you to consider when you start your healing journey. For more information, support, and resources in your own CIRS healing journey, visit TheCIRSGroup.com TIME STAMPS: 0:00 Intro and disclaimer 0:32 Why you start lipid replacement before you start binders 1:14 Side effects of binders that lipid replacement will help you with 3:00 How to know you're taking enough fats 4:02 How fats can impact your MMP9 level 4:52 The danger of taking too much lipid replacement 5:17 The lipid replacement options, starting with fish oils, Omaprem 6:39 Phosphatidylcholine 8:56 Plasmalogens 12:15 Do Neuro when you are in a “good place” 13:25 Consider staying on lipid replacement long term HELPFUL LINKS: Omaprem: https://www.nutritionwithjudy.com/shopping/inflammation/omaprem-spm-fatty-acids Fish Oils: https://shop.bioticsresearch.com/products/biomega-1000 Phosphatidylcholine: https://bodybio.com/products/bodybio-pc-phosphatidylcholine?variant=34379596136583&country=US¤cy=USD&utm_medium=product_sync&utm_source=google&utm_content=sag_organic&utm_campaign=sag_organic&utm_source=google&utm_medium=paid&utm_campaign=17855439090&utm_content=&utm_term=&tw_source=google&tw_adid=&tw_source=google&tw_adid=&tw_campaign=17855439090&gad_source=1&gclid=Cj0KCQiAkoe9BhDYARIsAH85cDMeyrEJAWstHbDJF9kLXOvoOkkwMRr9vNqqvEbSiUdYrXaJodENBlQaAkJsEALw_wcB Plasmalogens: Glia for repair (earlier in the protocol): https://prodrome.com/products/prodromeglia-softgel?variant=50891696930976 Neuro (to promote brain growth): https://prodrome.com/products/prodromeneuro-softgel?pr_prod_strat=jac&pr_rec_id=f4d553f7c&pr_rec_pid=7578764083360&pr_ref_pid=7578764214432&pr_seq=uniform&variant=50891105042592 The CIRS Group: Support Community: https://thecirsgroup.com Join us for our next live Q&A webinar! https://www.thecirsgroup.com/webinar Instagram: https://www.instagram.com/thecirsgroup/ Find Jacie for carnivore, lifestyle and limbic resources: Instagram: https://www.instagram.com/ladycarnivory YouTube: https://www.youtube.com/@LadyCarnivory Blog: https://www.ladycarnivory.com/ Order Jacie's book! https://a.co/d/8ZKCqz0 Find Barbara for business/finance tips and coaching: Website: https://www.actlikebarbara.com/ Instagram: https://www.instagram.com/actlikebarbara/ YouTube: https://www.youtube.com/@actlikebarbara Jacie is a Shoemaker certified Proficiency Partner, NASM certified nutrition coach, author, and carnivore recipe developer determined to share the life changing information of carnivore and CIRS to anyone who will listen. Barbara is a business and fitness coach, CIRS and ADHD advocate, speaker, and a big fan of health and freedom. Together, they co-founded The CIRS Group, an online support community to help people that are struggling with their CIRS diagnosis and treatment.

Section 1: Introduction (0:00 - 5:30) Dr. Valentin Fuster introduces a special issue on Prevention, covering societal and individual prevention aspects and key cardiovascular risk factors. He highlights issues like medication adherence, obesity, and the need for better education and healthcare systems. Section 2: Prevention in Society (5:30 - 35:30) Adherence to Medications The PURE trial shows low medication adherence (31% at follow-up) across 17 countries, despite technological advancements in diagnostics. Barriers include low health literacy and inadequate healthcare systems. Social Determinants of Health Social deprivation leads to worse cardiovascular outcomes, especially among sexual minorities in the U.S. The editorial calls for more equitable healthcare access and anti-stigma efforts. Environmental Factors: Aircraft Noise Higher aircraft noise exposure is linked to worse heart health, urging noise reduction policies for vulnerable populations. Section 3: Prevention in Individuals (35:30 - 55:30) Sedentary Behavior Even with exercise, high sedentary time (over 10.6 hours a day) increases cardiovascular risk. Reducing sedentary time can significantly lower heart disease risk. Intensive Lifestyle Interventions for Diabetes Weight loss and lifestyle changes improve cardiac biomarkers and reduce cardiovascular risk in type 2 diabetes patients. Section 4: Risk Factor Impacts (55:30 - 1:10:00) Hyperlipidemia & Obesity Hyperlipidemia and obesity management, including medications like semaglutide, play key roles in preventing cardiovascular disease. The 2024 ESC hypertension guidelines are also crucial in risk reduction.

Send us a message with this link, we would love to hear from you. Standard message rates may apply.This episode is a comprehensive episode designed to educate listeners about the complexities of cholesterol and its impact on cardiovascular health. The episode defines hyperlipidemia  detailing various types of lipids, including LDL, HDL, and triglycerides. The discussion covers recommended lipid screening guidelines, risk factors, and the importance of personalized risk assessment. By the end of this episode, listeners will have a deeper understanding of cholesterol and will be empowered to take proactive steps towards better heart health.Support the showProduction and Content: Edward Delesky, MD & Nicole Aruffo, RNArtwork: Olivia Pawlowski

Darshan H. Brahmbhatt, Podcast Editor of JACC: Advances, discusses a recently published original research paper on Preventive Lipid-Lowering Therapy and Interactions With Health Care in Patients Who Develop Premature Coronary Artery Disease.

In this podcast, expert clinicians will review the role of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors in reducing low-density lipoprotein cholesterol (LDL-C) and reducing cardiovascular risk. https://healio.com/cme/mededtalks/cardiology/20250102/4-lipid-legends-with-your-host-dr-ronald-codario-featuring-dr-peter-toth-pcsk9-inhibition

In this episode, we review the high-yield topic ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Lipid-Lowering Drugs⁠ ⁠⁠⁠⁠⁠⁠⁠⁠from the Cardiovascular section at ⁠⁠⁠⁠⁠⁠Medbullets.com⁠⁠⁠⁠⁠⁠ Follow ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Medbullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on social media: Facebook: www.facebook.com/medbullets Instagram: www.instagram.com/medbulletsofficial Twitter: www.twitter.com/medbullets Linkedin: https://www.linkedin.com/company/medbullets

BUFFALO, NY- January 7, 2025 – A new #research perspective was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 22 on December 9, 2024, entitled “Nuclear lipid droplets: a novel regulator of nuclear homeostasis and ageing.” In this article, Dr. Konstantinos Palikaras from the National and Kapodistrian University of Athens and Dr. Nektarios Tavernarakis from the University of Crete explore how tiny fat droplets, known as nuclear lipid droplets (nLDs), accumulate in the nucleus of cells as we age. Unlike regular lipid droplets, which store energy in the cytoplasm, these nuclear droplets may weaken the nucleus by disrupting critical cellular processes. The authors suggest that excessive buildup of nLDs could lead to nuclear instability and may be linked to metabolic conditions such as fatty liver disease, obesity-related disorders, and premature aging. This highlights the potential role of nLDs in cellular aging and age-related diseases. Previous research by the authors using Caenorhabditis elegans (C. elegans), a model organism commonly used to study aging, revealed the role of ATGL-1, an enzyme that regulates fat storage in the nucleus. When functioning properly, ATGL-1 helps maintain a healthy lipid balance. However, when it becomes inactive or overwhelmed, fat droplets build up around the nuclear lamina, making it more difficult for the cell to function properly. “These findings establish excessive nuclear lipid deposition as a key hallmark of aging, with profound implications for nuclear processes such as chromatin organization, DNA repair, and gene regulation.” The authors emphasize that lifestyle interventions, such as caloric restriction and better insulin regulation, can significantly reduce harmful nLD buildup, reinforcing the role of healthy metabolism in slowing cellular aging. They also call for further studies to understand how nLDs behave in human experimental models, particularly in patients with conditions like metabolic syndrome and progeria. A deeper understanding of these processes could lead to treatments designed to preserve cell health and delay age-related diseases. In summary, by presenting nuclear lipid droplets as potential therapeutic targets, this research perspective presents a new path for exploring treatments aimed at combating age-related diseases driven by lipid dysregulation. DOI - https://doi.org/10.18632/aging.206175 Corresponding authors - Konstantinos Palikaras - palikarask@med.uoa.gr, and Nektarios Tavernarakis - tavernarakis@imbb.forth.gr Video short - https://www.youtube.com/watch?v=vuSLuDk8Xjk Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206175 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, ATGL-1, HLH-30/TFEB, lipid droplet, non-linear optical phenomena, nucleus About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Dr. Colleen Walsh-Irwin joined NP Pulse to discuss updated treatment guidelines for hyperlipidemia and much more. Walsh-Irwin has been an NP for almost thirty years and runs a national program for evidence-based practice. In addition to discussing new medications for treating hyperlipidemia, Walsh-Irwin shares how she utilizes her own visual aides to help her patients understand their health issues and treatment.  And for all things Cardiovascular related, consider joining the AANP Community group: Cardiology Specialty Practice, which offers the opportunity to interactively collaborate with colleagues who share interest or clinical expertise on the subject. 

In this conversation, Dr. Sam Sigoloff interviews Richard Hirschman, a trade embalmer, about the alarming discovery of unusual clots found in deceased individuals, particularly in relation to the COVID-19 pandemic. Hirschman shares his experiences and findings, detailing the characteristics of these clots, their potential links to amyloid proteins, and the implications for public health. The discussion highlights the role of embalmers in uncovering medical anomalies and raises concerns about the broader health impacts of these findings. In this segment of the conversation, Dr. Sam Sigoloff and Richard Hirschman delve into the perplexing phenomenon of clot formation in both veins and arteries, particularly in the context of COVID-19. They discuss the implications of autopsy findings, the unusual presence of amyloid clots, and the potential connections to vaccines. The dialogue also touches on the role of lipid nanoparticles and the broader implications of emergency use authorization in the context of public health and safety. In this conversation, Richard Hirschman and Dr. Sam Sigoloff delve into the alarming discovery of micro-clots in blood samples, potentially linked to vaccines and COVID-19. They discuss the challenges faced in medical research, the erosion of trust in the medical system, and the ethical dilemmas surrounding the reporting of vaccine-related injuries. The dialogue emphasizes the need for further investigation into the causes of these clots and a collective call to action for the medical community and society at large.TakeawaysRichard Hirschman has documented over 200 unusual clots since 2021.The clots are unlike anything seen prior to the pandemic.Amyloid proteins are being found in these clots, raising health concerns.The presence of amyloid in the bloodstream is alarming.There is a potential link between these clots and vaccine injuries.Embalmers are observing changes in blood that are not typical post-mortem clots.The clots are dense and do not fall apart like normal clots.There is a need for further research into the nature of these clots.The conversation highlights the importance of embalmers in medical discoveries.The findings could explain various health issues being reported post-vaccination. Autopsies typically focus on organ examination, not detailed vascular analysis.Clots are usually found in veins, not arteries, raising concerns about new findings.The presence of amyloid in clots suggests a significant change in clot composition post-COVID.Vaccine-induced thrombotic thrombocytopenia is a rare but concerning phenomenon.Lipid nanoparticles may play a role in abnormal clotting mechanisms.Emergency use authorization was declared amidst a perceived attack on public health.The presence of amyloid-like structures in blood raises questions about vaccine safety.Research indicates a potential link between spike proteins and abnormal clotting.The discussion highlights the need for further investigation into vaccine-related health issues.The conversation emphasizes the importance of transparency in medical research and public health policies. There is a significant presence of micro-clots in blood samples.Micro-clots may be linked to a new blood-borne amyloid clotting syndrome.Observation and documentation are crucial in identifying unusual medical phenomena.Medical research faces challenges in funding and peer review processes.Trust in the medical system has been severely impacted by COVID-19 protocols.The correlation between vaccines and abnormal clots is a growing concern.Ethical dilemmas arise when reporting potential vaccine injuries.Not everyone experiences the same reactions to vaccines, but harm does occur.A spiritual perspective is essential in addressing the current health crisis.Community leaders must advocate for truth and transparency in medical practices.lf you like my t-shirt please get one here:
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Welcome to my podcast. I am Doctor Warrick Bishop, and I want to help you to live as well as possible for as long as possible. I'm a practising cardiologist, best-selling author, keynote speaker, and the creator of The Healthy Heart Network. I have over 20 years as a specialist cardiologist and a private practice of over 10,000 patients. In this podcast, Dr. Warrick Bishop discusses the movement of lipids and lipoprotein particles in the body, emphasizing their role in delivering energy sources. He explains that dietary fats absorbed in the gut form chylomicrons, which enter the bloodstream and release triglycerides to tissues via the enzyme lipoprotein lipase. As triglycerides are removed, these particles become denser and transform into intermediate and low-density lipoproteins (IDL and LDL), which are remnants of energy delivery. The liver produces very low-density lipoproteins (VLDL) to perform a similar function.

Menopause is one of those things no one really prepares you for, right? The sleepless nights, the cravings, the mood swings—it can feel like your body is running the show. That's why I sat down with two brilliant women, Cynthia Thurlow, a Functional Nutrition expert with over 15 million views on her TEDx talk about intermittent fasting, and Dani Williamson, a powerhouse in Integrative Medicine specializing in gut, thyroid, and hormone health, to talk about real, practical ways to make this phase of life not just manageable but empowering. From hormones to heart health to inflammation, they're sharing the stuff every woman needs to know to feel like herself again—maybe even better.   We chat about everything from creating a distraction-free sleep sanctuary to tackling inflammation and dialing in your hormones. These simple changes can make a huge difference, and you don't have to go through it alone—we're figuring it out together.   Cynthia breaks down the numbers every woman should know to protect her heart health (yes, it's about more than cholesterol), while Dani talks about the surprising ways stress wreaks havoc on your hormones. We're also getting into the hidden role of inflammation in menopause and how your diet and lifestyle choices can either fuel the fire or calm things down. Plus, there's an eye-opening conversation about setting boundaries to create space for what really matters—your health and happiness. Trust me, you'll leave this episode feeling inspired and ready to take charge!   If you're ready to feel your best, let's do this together! My Keto-Green 16 Challenge is coming up, and it's designed to help you reset after the holidays. Whether it's cravings, stress, or just needing a fresh start, this 16-day journey can boost your energy, mood, and more. Head over to dranna.com/challenge to join me—we're in this together!     Key Timestamps: [00:02:00] World Menopause Day series. [00:07:07] Inflammation and hormone imbalance. [00:10:22] Diet will heal or kill. [00:11:34] Alcohol as a sleep disruptor. [00:14:14] Bedroom sanctuary for menopause. [00:19:24] Menopause and its liberation. [00:21:48] EMF exposure and health risks. [00:26:34] The happiness hormone: pregnenolone. [00:30:10] Automate, eliminate, and delegate. [00:34:38] Women's heart health and menopause. [00:39:14] Insulin and triglyceride levels. [00:46:27] Lipid changes post-menopause. [00:51:48] Coronary artery calcification assessment. [00:53:39] Statins and heart health testing. [01:02:14] Low hormones and heart health. [01:03:17] Holiday heart and stroke risk. [01:06:18] Transforming your health journey.     Memorable Quotes: "Your diet will heal you or kill you. It is as simple as that. There is no in-between. And when you take the emotion out of food—which is what I have learned—you've just got to take the emotion out of it, and you've got to eat to live, not live to eat." [00:10:15] – Dani Williamson "Statistically, women are most likely to die from heart disease. That's why this conversation is so important. And certainly, we live longer than men... but if we don't take care of ourselves—you know, we are the caretakers for everyone else—if we are not taking care of ourselves, we are going to end up having a lower quality of life as we get older." [00:37:56] – Cynthia Thurlow     Links Mentioned: Keto-Green 16 Challenge: https://dranna.com/challenge Prevencio Tests: https://prevenciomed.com/   Connect with Dani Williamson: Website: https://daniwilliamson.com/ Instagram: https://www.instagram.com/daniwilliamsonwellness/ Facebook: https://www.facebook.com/DaniWilliamson YouTube: https://www.youtube.com/@DaniWilliamsonWellness TikTok: https://www.tiktok.com/@daniwilliamsonwellness   Connect with Cynthia Thurlow: Website: https://www.cynthiathurlow.com/ Instagram: https://www.instagram.com/cynthia_thurlow_/ Facebook: https://www.facebook.com/CHTWellness X/Twitter: https://x.com/_CynthiaThurlow TikTok: https://www.tiktok.com/@cynthia_thurlow_ Apple Podcast: Everyday Wellness with Cynthia Thurlow Spotify Podcast: Everyday Wellness with Cynthia Thurlow   Connect with Dr. Anna Cabeca: Website: https://drannacabeca.com/pages/show Instagram: https://www.instagram.com/thegirlfrienddoctor/ YouTube: https://www.youtube.com/@thegirlfrienddoctor TikTok: https://www.tiktok.com/@drannacabeca   Produced by Evolved Podcasting: www.evolvedpodcasting.com

In this episode of the Poultry Nutrition Blackbelt Podcast, Dr. Peter Ferket from N.C. State University continues exploring lipid matrix microencapsulation technology. He shares significant findings on improved nutrient absorption, reduced vitamin dosages, and enhanced feed efficiency. Dr. Ferket also emphasizes the technology's applications for broiler breeders, including increased egg production and healthier progeny. Tune in now on all major platforms."Broiler breeders delivered four more eggs per hen and improved progeny robustness with lipid matrix technology."Meet the guest: Dr. Peter Ferket, William Neal Reynolds Distinguished Professor at N.C. State University holds a B.S. and M.S. in Animal and Poultry Science from the University of Guelph and a Ph.D. in Animal Nutrition from Iowa State University. He is also a member of the Poultry Science Association. Dr. Ferket conducts nutrition and metabolism research and education programs related to enhancing productivity and health and the formulation and manufacture of quality feeds. Click here to read the full research article!What you'll learn:(00:00) Highlight(01:24) Introduction(02:47) Technology basics(04:21) Nutrient time-release(06:09) Lipid encapsulation(06:55) Performance gains(09:09) Future research(12:44) Closing thoughtsThe Poultry Nutrition Blackbelt Podcast is trusted and supported by innovative companies like:* Kerry- BASF- Anitox- Poultry Science Association- Kemin

Send us a textIn this episode, we discuss PMS (Premenstrual Syndrome) and PMDD (Premenstrual Dysphoric Disorder), along with the impact of hormonal imbalances on mood, energy, and overall well-being. I am joined by Dr. Kelly Ruef from Dutch, a naturopathic physician with a strong interest in biochemistry, biochemical pathways, and natural hormone pathways. She will explain how tools like the Dutch Test can help uncover what is happening beneath the surface and provide steps you can take to feel better.What You'll Learn in This Episode: -  The Role of Hormonal Fluctuations in PMS and PMDD*     We dive into why some women experience extreme symptoms during the luteal phase and the role hormones like progesterone and estrogen play in mood regulation. - The Connection Between Progesterone and GABA  Dr. Kelly explains how progesterone and its metabolites impact GABA, an inhibitory neurotransmitter that helps regulate anxiety, irritability, and sleep. We explore why low progesterone—or how your body processes it can lead to anxiety, irritability, and poor sleep. - Understanding Estrogen Dominance  Ever feel overly emotional, get headaches, or have heavy periods? These can all be signs of too much estrogen relative to progesterone. We also discuss how the balance between estrogen and progesterone plays a critical role. - The Paradoxical GABA Response  Dr. Kelly uncovers the phenomenon where some women experience increased anxiety and irritability during their luteal phase due to a paradoxical response to progesterone metabolites. - Why the Dutch Test is a Game Changer     Learn how this advanced hormone test provides a full picture of your hormonal health, helping uncover the root cause of your symptoms. - Cholesterol, Lipids, and Estrogen   Explore the surprising link between estrogen and lipid health and why low estrogen can affect cholesterol levels. Quick Tip:  Simple lifestyle changes, like getting better sleep, managing stress, and stabilizing blood sugar are powerful first steps to better hormonal health before diving into more advanced protocols. Connect with Dr Kelly Ruef on InstagramLET ME HELP YOU FIX THOSE HORMONES:FREE RESOURCESLove Your Liver GuideHormone Imbalance QuizCOURSE + COACHING (When you're ready to fix your hormones without the drama of figuring it out on your own)Disclaimer: Nothing in this podcast is to be taken as medical advice, please take informed accountability and speak to your provider before making changes to your health routine.This podcast is for women and moms to learn how to balance hormones naturally, to have better periods, increased fertility, to decrease PMS mood swings, and to increase energy without restrictive diet plans. You'll learn how to balance blood sugar, increase progesterone naturally, understand the root cause of estrogen dominance, irregular periods, PCOS, insulin resistance, hormonal acne, post birth-control syndrome, and conceive naturally. If you listen to any of the following shows, we're sure you'll like ours too! Pursuit of Wellness with Mari Llewellyn, Culture Apothecary with Alex Clark, Found My Fitness with Rhonda Patrick, Just Ingredients Podcast, Wellness Mama, The Dr Josh Axe Show, Are You Menstrual Podcast, The Model Health Show, Grounded Wellness By Primally Pure, Be Well By Kelly Leveque, The Freely Rooted Podcast with Kori Meloy, Simple Farmhouse Life with Lisa Bass

In this episode of The Poultry Nutrition Blackbelt Podcast, Dr. Peter Ferket from N.C. State University shares his expertise on lipid matrix microencapsulation technology. This groundbreaking approach enhances vitamin stability, boosts bioavailability, and optimizes feed efficiency, addressing critical challenges in poultry nutrition. Tune in now to this essential discussion, available on all major platforms."Lipid matrix encapsulation safeguards nutrients, reducing degradation caused by moisture, heat, and other environmental factors."Meet the guest: Dr. Peter Ferket, William Neal Reynolds Distinguished Professor at N.C. State University holds a B.S. and M.S. in Animal and Poultry Science from the University of Guelph and a Ph.D. in Animal Nutrition from Iowa State University. He is also a member of the Poultry Science Association. Dr. Ferket conducts nutrition and metabolism research and education programs related to enhancing productivity and health and the formulation and manufacture of quality feeds. Click here to read the full research article!What you'll learn:(00:00) Highlight(01:17) Introduction(05:22) Lipid matrix microencapsulation(06:29) Vitamin & mineral stability(07:17) Bioavailability advantages(08:51) Feed handling improvements(10:55) Long-term nutrient efficacy(11:34) Closing thoughtsThe Poultry Nutrition Blackbelt Podcast is trusted and supported by innovative companies like:* Kerry- Poultry Science Association- Kemin- BASF- Anitox

In this episode of Longevity Roadmap, Buck Joffrey presents a case study of a 70-year-old patient with optimal metabolic health but elevated LDL and APOB levels, emphasizing the importance of aggressive lipid management in preventing coronary artery disease. Buck also explores the genetic factors related to Alzheimer's risk and the implications of lipid levels on cognitive health, advocating for proactive treatment strategies. 00:00 - Introduction to Longevity Roadmap 03:08 - Case Study: A 70-Year-Old Patient's Health 12:07 - Understanding Lipid Management and Atherosclerosis 19:49 - Genetic Factors in Alzheimer's Risk and Lipid Management

This Real Science Exchange episode was recorded during a webinar, which was part of a series. Watch all the presentations from this series here: https://balchem.com/animal-nutrition-health/resources-categories/real-science-lecture-series/previous-lectures/page/10/Early in lactation, the cow is incapable of eating enough to meet her dramatically increased requirements. As the cow's intake decreases near calving, there are fewer nutrient contributions from dry matter intake and she must alter nutrient partitioning to meet her increased needs by mobilizing fat and muscle stores. (1:18)Triglycerides from fat stores are broken down into non-esterified fatty acids (NEFA) and glycerol. NEFA has two different fates in the postpartum cow: to the mammary gland as a precursor for milk fat synthesis, or to the liver to be oxidized for energy production. Glycerol enters the gluconeogenic pathway in the liver as a glucose precursor. (4:41)The capacity for the liver to use NEFA for energy is limited by the capacity of the TCA cycle. When the TCA cycle is at capacity, excess NEFA can either undergo incomplete oxidation to ketones or be repackaged back into triglycerides. If the capacity for other tissues to use ketones for energy is exceeded, then blood concentrations of ketones rise and negative outcomes from subclinical and clinical ketosis can occur. If triglycerides accumulate in the liver, negative outcomes associated with fatty liver can occur. Triglycerides can be transported out of the liver via very low-density lipoprotein (VLDL) export; however, VLDL export does not keep up with triglyceride concentration during the transition period in dairy cows, largely because of a limiting amount of phosphatidylcholine. (5:51)Dr. White describes a series of experiments in her lab using liver cells in culture to investigate the relationship between choline supplementation and VLDL export. As choline supplementation to the cell culture increased, so did VLDL export from the cells into the media. In addition, increasing choline supplementation to the cell culture also decreased cellular triglyceride content. (10:54)Using gene expression and radiolabeled tracers over a series of experiments, Dr. White's group found that as choline supplementation increased, so did complete oxidation of NEFA to energy. This was accompanied by decreased incomplete oxidation to ketone bodies and decreased accumulation of lipids in the liver cells. Glucose and glycogen were also increased with increasing choline supplementation to the cell culture, and a decrease in reactive oxygen species was observed. In addition, choline-supplemented cultures exhibited an increase in metabolic pathways associated with methionine regeneration and methyl donation. (15:29)Dr. White then details the complexity of the metabolic pathways that intersect between choline and methionine. In similar experiments supplementing cell cultures with increasing amounts of methionine and choline, there were no effects of methionine on lipid export, oxidative pathways, or glucose metabolism. The main benefit of methionine was a marked increase in glutathione production. It's important to note that no interactions between choline and methionine were observed in this series of experiments. (19:37)There seems to be a clear biological priority for different sets of pathways for choline and methionine. Choline seems to be influencing lipid, glucose, and oxidative pathways, while methionine is primarily serving its role as an essential amino acid for cellular protein structure and generation, acting as a methyl donor, and impacting inflammation. Importantly, both the choline and methionine results observed in cell culture are paralleled in transition dairy cow studies. (24:14)Dr. White's lab further investigated the impact of methionine on inflammation. When cells were challenged with LPS to provoke an inflammatory response, methionine mitigated the inflammatory response. Similar results have been observed in liver tissue samples of transition cows. Methionine mitigated inflammatory markers and increased glutathione but did not influence reactive oxygen species. Conversely, choline decreased reactive oxygen species but did not change glutathione. (27:47)Choline and methionine are both essential nutrients, there are biological priorities for them as methyl donors, and they are not mutually exchangeable. The lack of interaction between choline and methionine in vivo or in vitro supports the idea of different biological roles for these nutrients. (32:09)Dr. White takes questions from the webinar audience. (34:53)Please subscribe and share with your industry friends to invite more people to join us at the Real Science Exchange virtual pub table.  If you want one of our Real Science Exchange t-shirts, screenshot your rating, review, or subscription, and email a picture to anh.marketing@balchem.com. Include your size and mailing address, and we'll mail you a shirt.

In this controversial episode, Melanie dives into the research and health claims behind the growing-in-popularity Carnivore Diet, including the claim it can help prevent kidney stones. Blog: Why is Evidence Based Nutrition So Important?  Blog: Can Too Much Protein Cause Kidney Stones?   Ermer T, Nazzal L, Tio MC, Waikar S, Aronson PS, Knauf F. Oxalate homeostasis. Nat Rev Nephrol. 2023 Feb;19(2):123-138. Hu FB. Plant-based foods and prevention of cardiovascular disease: an overview. The American Journal of Clinical Nutrition. 2003;78(3):544S-551S. Mohamadi A, Shiraseb F, Mirzababaei A, et al. Circulating Inflammatory Markers May Mediate the Relationship between Healthy Plant-Based Diet and Metabolic Phenotype Obesity in Women: A Cross-Sectional Study. International Journal of Clinical Practice. 2022;2022(1):8099382. Suarez-Lledo V, Alvarez-Galvez J Prevalence of Health Misinformation on Social Media: Systematic Review. J Med Internet Res 2021;23(1):e17187 Turner KM, Keogh JB, Meikle PJ, Clifton PM. Changes in Lipids and Inflammatory Markers after Consuming Diets High in Red Meat or Dairy for Four Weeks. Nutrients. 2017 Aug 17;9(8):886. Wilson HE, Moe SM. You are what you eat: should it be all meat? FR-PO1072. Abstract of a poster presented at the American Society of Nephrology Kidney Week 2024; October 25, 2024;San Diego, California. (referenced in Docwire News) Zhangling Chen, Jean-Philippe Drouin-Chartier, Yanping Li, Megu Y. Baden, JoAnn E. Manson, Walter C. Willett, Trudy Voortman, Frank B. Hu, Shilpa N. Bhupathiraju; Changes in Plant-Based Diet Indices and Subsequent Risk of Type 2 Diabetes in Women and Men: Three U.S. Prospective Cohorts. Diabetes Care 1 March 2021; 44 (3): 663–671.   Submit a question for Melanie to answer on the podcast! Connect with The Kidney Dietitian! Work with Us! |  Instagram | Facebook | Pinterest | Facebook Group | Newsletter www.thekidneydietitian.org All information in this podcast is meant for educational purposes only and should not be used in place of advice from a medical professional.  

To help us unpack all the research and studies we have Dr. Stengler joining us today.In addition to authoring 30 books on health and several best-sellers such as “The Natural Physician's Healing Therapies,” “Prescription for Natural Cures,” “Prescription for Drug Alternatives,” and “Outside the Box Cancer Therapies,” Dr. Stengler has been published in several peer-reviewed medical journals such as The International Journal of Family & Community Medicine, Endocrinology & Metabolism International Journal, and Journal of Nutritional Health & Food Engineering.Dr. Stengler's, NMD. The newest book is called, The Holistic Guide to Gut Health. A comprehensive yet accessible approach to healing leaky gut and the many uncomfortable symptoms it causes. Dr Stengler is also the founder of The Stengler Center for Integrative Medicine.Talking Points:Palmitoylethanolamide, is a naturally occurring fatty acid derivative made in the body and found in small amounts in foods. Several human studies have demonstrated that PEA has broad-spectrum pain-relieving properties, anti-inflammatory effects, and nerve protection.PEA was first discovered in 1957 by scientists at Merck Sharp & Dome, who isolated it from egg yolk, peanut meal, and soy lecithin. They found that PEA had anti-inflammatory properties in guinea pigs.However, PEA's role as a potential therapeutic agent was not widely recognized until 1993, when Rita Levi-Montalcini and her colleagues published research that suggested PEA has anti-inflammatory properties. Levi-Montalcini's group termed PEA an autocoid local injury antagonist (ALIA), and suggested that it acts locally to counteract injuryMultiple studies have demonstrated that PEA improves all sorts of pain. For example, a 2023 analysis of 11 studies found that PEA improved pain of various conditions, including muscle and joints, nerves, gynecological, and digestive. In terms of joint pain, a high-quality study demonstrated that PEA significantly reduced adult joint pain compared to placebo. Moreover, 8 clinical trials demonstrated that PEA was effective for low back pain, sciatica, and carpal tunnel syndrome. Even migraine headache pain was shown in published research to be improved with PEA.Lipid mediators help to balance the immune, nervous, and endocrine systems, affecting pain pathways related to inflammation. But unfortunately, due to changing diets, many of us do not get the nutrition and activity we need to make enough PEA ourselves. Learn more about Emerald Labs PEA+ LevagenUse the code: Forever and get 20% off your order.

Does the triglyceride to HDL ratio really matter? Cardiologist lipid expert explains the TG:HDL ratio and what you really need to worry about. https://dralo.net/links

In this episode, CardioNerds Dr. Gurleen Kaur and Dr. Akiva Rosenzveig are joined by Cardio-Rheumatology experts, Dr. Brittany Weber and Dr. Michael Garshick to discuss treating inflammation, delving into the pathophysiology behind the inflammatory hypothesis of atherosclerotic cardiovascular disease and the evolving data on anti-inflammatory therapies for reducing ASCVD risk, with insights on real-world implementation. Show notes were drafted by. Dr. Akiva Rosenzveig. This episode was produced in collaboration with the American Society of Preventive Cardiology (ASPC) with independent medical education grant support from Lexicon Pharmaceuticals. CardioNerds Prevention PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls - Treating Inflammation Our understanding of the pathophysiology of atherosclerosis has undergone a few iterations from the incrustation hypothesis to the lipid hypothesis to the response-to-injury hypothesis and culminating with our current understanding of the inflammation hypothesis. Both the adaptive and innate immune systems play instrumental roles in the pathogenesis of atherosclerosis. After adequately controlling classic modifiable risk factors such as blood pressure, dyslipidemia, glucose intolerance, and obesity, systemic inflammation as assessed by CRP can be ascertained as CRP is associated with ~1.8-fold increased risk of cardiovascular events Although the most common side effect of colchicine is gastrointestinal intolerance, colchicine can induce lactose intolerance, so a lactose free diet may help ameliorate colchicine-induced GI symptoms. Anti-inflammatory therapeutics have shown promise in reducing cardiovascular risk but much more is to be learned with ongoing and future basic, translational, and clinical research. Show notes - Treating Inflammation What are the origins of the inflammatory hypothesis? The first hypothesis as to the pathogenesis of atherosclerosis was the incrustation hypothesis by Carl Von Rokitansky in 1852. He suggested that atherosclerosis begins in the intima with thrombus deposition.In 1856, Rudolf Virchow suggested the lipid hypothesis whereby high levels of cholesterol in the blood lead to atherosclerosis. He observed inflammatory changes in the arterial walls associated with atherosclerotic plaque growth, called endo-arteritis chronica deformans.In 1977, Russell Ross suggested the response-to-injury hypothesis, that atherosclerosis develops from injury to the arterial wall.In the 1990's the role of inflammation in ASCVD became more recognized. Both the adaptive and innate immune system are critical in atherosclerosis. Lipids and inflammation are synergistic in that lipid exposure is required but they translocate through damaged endothelium which occurs by way of inflammatory cytokines, namely within the NLRP3 inflammasome (IL-1, IL-6 etc.).Smooth muscle cells are also involved. They migrate to the endothelial region and secrete collagen to create the fibrous cap. They can also transform into macrophage-like cells to take up lipids and become foam cells. T, B, and K cells are also part of this milieu. In fact, neutrophils, macrophages and monocytes make up only a small portion of the cells involved in the atherosclerotic process. What are ways to individually optimize one's ASCVD risk?Ensure the patient is on appropriate antiplatelet therapy, lipid lowering therapy, blood pressure is well controlled, and the Hemoglobin A1c is well controlled. Smoking cessation is pivotal.If the patient has an elevated Lipoprotein (a), pursue more aggressive lipid lowering therapy. Targeted therapies may become available in the future. Assess the patient's systemic inflammatory risk as measured by C-Reactive Protein (CRP)

Choosing the right supplements for you can be challenging - and sometimes expensive. But some supplements pack more punch per dollar than others! Jared's mission is always to teach you to master natural supplements and part of that is knowing where you can get the most bang for your buck. On this episode of Vitality Radio, Jared begins a new series where he shares three supplements that cost less than 50 cents a day but are incredibly effective for some of the biggest health concerns people have. You'll learn about creatine, selenium, and chromium, and their benefits for muscle health, prevention of neurodegenerative disease, cardiovascular health, cancer prevention, hormone balance, insulin resistance, and overall metabolic health, so that you can decide if these affordable supplements are right for you and your budget.Products:NutraBio Creatine MonohydrateSunwarrior Active CreatineNatural Factors SelenoExcell SeleniumVital 5 Ultimate Vitality MultiNatural Factors Chromium GTFAdditional Information:#408: Creatine for More Than Muscle - Mitochondria, Brain, Heart, Gut, Skin Health, and More!#347: Thyroid Health: Why Your Doctor Might Be Looking at the Wrong Numbers With Dr. Todd CameronVisit the podcast website here: VitalityRadio.comYou can follow @vitalitynutritionbountiful on Instagram, or Vitality Radio and Vitality Nutrition on Facebook. Join us also in the Vitality Radio Podcast Listener Community on Facebook. Shop the products that Jared mentions at vitalitynutrition.com. Let us know your thoughts about this episode using the hashtag #vitalityradio and please rate and review us on Apple Podcasts. Thank you!Just a reminder that this podcast is for educational purposes only. The FDA has not evaluated the podcast. The information is not intended to diagnose, treat, cure, or prevent any disease. The advice given is not intended to replace the advice of your medical professional.

Become a member of The Metabolic Initiative to access exclusive ad-free episodes and earn CMEs: https://membership.metabolicinitiative.comIn this episode, we're sharing a presentation from Metabolic Health Summit 2024 that dives into a groundbreaking experiment titled "Oreo vs. Statin," by researcher-educator Nick Norwitz, PhD. What started as a personal journey with metabolic health turned into a captivating exploration of the lipid energy model and lean mass hyper responders. Dr. Norwitz shares the dramatic results of his unorthodox study, where a diet consisting primarily of Oreos led to a jaw-dropping 70% reduction in LDL cholesterol. We discuss the implications of his findings, the challenges he's faced in the scientific community, and the importance of asking uncomfortable questions in pursuit of knowledge. This episode is an opportunity to watch an engaging lecture filled with scientific awe, unexpected results, and a call to action for more open-minded discussions in metabolic health!Dr. Nick Norwitz has a mission to “Make Metabolic Health Mainstream.” He graduated Valedictorian from Dartmouth College in 2018, majoring in Cell Biology and Biochemistry. He then completed his PhD in Metabolism at the University of Oxford in 2021, before attending Harvard Medical School to complete his MD. Dr. Norwitz enthusiasm for the field of Metabolism derives from a personal struggle with severe Inflammatory Bowel Disease that left him physically emaciated, mentally depleted, and emotionally fragmented. In desperation, he found that a ketogenic diet put his disease into remission where conventional approaches had failed.Special thanks to the sponsor of this episode: Genova Connect, powered by Genova Diagnostics offers easy access to advanced lab tests. Receive 15% off any of their tests with code metaboliclink at https://gdx.net/themetaboliclinkLearn more about Dr. Norwitz here: https://www.nicknorwitz.comIn every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!You can find us on all your major podcast players here and full episodes are also up on our Metabolic Health Summit YouTube channel!Find us on social: Instagram Facebook YouTube LinkedIn Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.

When discussing cardiovascular health, few topics stir as much debate as cholesterol, particularly in relation to low-carb and ketogenic diets. Recently, there's been significant attention given to a proposed model that suggests high LDL cholesterol may not pose the same cardiovascular risk in certain individuals, specifically those labeled as “lean mass hyper-responders.” This raises important questions: Is it possible that high cholesterol might not be dangerous for everyone? Or are we witnessing a dangerous misinterpretation of the science? In this episode, we break down the ideas behind the “lipid energy model” and explore how it has been framed in the context of low-carbohydrate and ketogenic diets. While proponents claim this model sheds light on how some people can have elevated LDL without increasing heart disease risk, critics warn that miscommunication and oversimplification of these ideas are leading many down a dangerous path. With real-world health decisions hanging in the balance, it's crucial to carefully examine what the science truly says about cholesterol, inflammation, and heart disease. Join us as we dive into the evidence with Dr. Gary McGowan. We'll dissect what the current research supports, what remains speculative, and how social media has amplified both the promising and problematic aspects of this model. If you've ever wondered about the impact of high cholesterol on heart disease risk in the context of ketogenic or low-carb diets, this episode is essential listening. Timestamps 02:27 What are the “Lean Mass Hyper Responder” phenotype and the “Lipid Energy Model” 27:29 Looking at recent publications and the “KETO Trial” 47:06 Public communication and misinterpretation 51:18 Clinical implications of diet-induced dyslipidemia 55:14 Responsibility in scientific communication 57:30 Real-world examples of poor communication or misinterpretation 01:13:27 Ethical concerns with the promotion of the model 01:25:59 Final thoughts Related Resources Go to episode page Join the Sigma email newsletter for free Subscribe to Sigma Nutrition Premium Enroll in the next cohort of our Applied Nutrition Literacy course Find Dr. McGowan at: Triage Method Instagram: @drgarymcgowan Papers discussed in this episode: Norwitz et al., 2022 – The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets Norwitz et al., 2021 – Elevated LDL Cholesterol with a Carbohydrate-Restricted Diet: Evidence for a “Lean Mass Hyper-Responder” Phenotype KETO Trial: Budoff et al., 2024 – Carbohydrate Restriction-Induced Elevations in LDL-Cholesterol and Atherosclerosis

Buck interviews Dr. Dennis Hughes, a concierge physician with a special interest in lipidology. They discuss the complexities of cholesterol, the importance of understanding lipid profiles, and the role of various lipoproteins in cardiovascular health. Dr. Hughes emphasizes the need for modern medicine to move beyond outdated notions of 'good' and 'bad' cholesterol, advocating for a more nuanced understanding of lipid management. The discussion also covers key lab tests, the significance of apolipoprotein B, and the future of pharmacotherapy in lipid management. 04:51 Understanding Cholesterol: Beyond Good and Bad   08:25 Key Lab Tests for Lipid Management   11:12 The Role of Apolipoprotein B in Cardiovascular Health   14:44 The Complexities of HDL and Its Functions   19:11 The Misconceptions Around LDL and HDL Ratios   34:42 Pharmacotherapy: Statins and Beyond

Send us a textFull version available on Substack and YouTube.About the guest: Nick Norwitz, PhD received his PhD in Physiology at Oxford University and is finishing his MD degree at Harvard Medical School. He is also an independent content creator focused on making metabolic health mainstream.Episode summary: Nick and Dr. Norwitz discuss: blood lipids & cholesterol; high cholesterol levels and what they can mean for different people; the “lean mass hyper-responder” phenotype to carb restriction; ketogenic & carnivore diets; public trust in medical & science institutions; n=1 (“n of one”) science experiments; and more.Related episodes:M&M 158: Ketosis & Ketogenic Diet: Brain & Mental Health, Metabolism, Diet & Exercise, Cancer, Diabetes | Dominic D'AgostinoIS #1: Seed Oils, Chronic Disease, Diet & Religious Cults, Mainstream Medicine vs. Independent Research | Tucker Goodrich*This content is never meant to serve as medical adviceSupport the showAll episodes (audio & video), show notes, transcripts, and more at the M&M Substack Affiliates: MASA Chips—delicious tortilla chips made from organic corn and grass-fed beef tallow. No seed oils, artificial ingredients, etc. Use code MIND for 20% off. SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount. Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off. Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase. Learn all the ways you can support my efforts

Welcome to my podcast. I am Doctor Warrick Bishop, and I want to help you to live as well as possible for as long as possible. I'm a practising cardiologist, best-selling author, keynote speaker, and the creator of The Healthy Heart Network. I have over 20 years as a specialist cardiologist and a private practice of over 10,000 patients. In this podcast, Dr. Warrick Bishop discusses the significance of vitamin K, particularly its roles in blood coagulation and bone health. Vitamin K is a fat-soluble vitamin essential for blood clotting and is administered to newborns to prevent bleeding complications. The conversation highlights the two forms of vitamin K: K1, found in green leafy vegetables, and K2, which has various subtypes and is involved in bone mineralization through the protein osteocalcin. Dr. Bishop explains how vitamin K helps regulate the balance between osteoblasts (bone-building cells) and osteoclasts (bone-resorbing cells), thereby impacting conditions like osteoporosis and aortic valve disease.

Ray improved mental health, mental clarity, joint pain, and weight loss (90lbs) on a carnivore diet. Instagram: @carnivoreray_ Twitter: @carnivoreray YouTube: carnivoreray Timestamps: 00:00 Trailer. 00:48 Introduction. 08:23 Video went viral unexpectedly. 10:30 Carnivore diet improved health beyond just weight. 15:20 Newsweek interview. 19:19 Lipid model. 22:07 Diabetes intervention. 23:49 Smooth transition to carnivore. 26:56 Carnivore diet misrepresented by extreme examples. 30:36 Society's diet habits influenced by modern lifestyle. 33:37 Carnivore diet life-changing. 36:23 Quitting loan officer career for social media. 38:07 "Don't give a rip." 40:54 Internet feedback anonymous and harsh. 45:46 Weight regain. 48:18 Where to find Carnivore Ray. See open positions at Revero: https://jobs.lever.co/Revero/ Join Carnivore Diet for a free 30 day trial: https://carnivore.diet/join/ Carnivore Shirts: https://merch.carnivore.diet Subscribe to our Newsletter: https://carnivore.diet/subscribe/ . ‪#revero #shawnbaker #Carnivorediet #MeatHeals #HealthCreation   #humanfood #AnimalBased #ZeroCarb #DietCoach  #FatAdapted #Carnivore #sugarfree  ‪

Today, I am excited to share the first class in a series of lipid masterclasses with the amazing Dr. Thomas Dayspring! Dr. Dayspring is certified in internal medicine and clinical epidemiology and is a fellow of the American College of Physicians and the National Lipid Association. He was previously the Educational Director of a nonprofit organization and has served as the Chief Academic Advisor for two major cardiovascular labs.  Due to the in-depth nature of my discussions with Dr. Dayspring over several sessions, each lasting nearly six hours, it seemed logical to present these masterclasses in segmented chunks to make them easier to understand. In our first class today, we dive into the fundamentals, exploring what lipids are and how lipids and fatty acids are classified. We cover the physiology and transportation of cholesterol and the role of apoptosis, apo-proteins, and apo-lipoproteins, unravel the differences between HDL, LDL, IDL, and VLDL, and explain how to calculate LDLs and triglycerides for assessing metabolic health. Dr. Dayspring also shares his preferences regarding lab values and the indicators that provide information to help him determine the early risk of cardiovascular disease. We get into some detailed aspects of physical chemistry in this episode, so I highlight the main clinical points throughout our conversation to make it more understandable. Be sure to join Dr. Dayspring and me for our next episode in the lipid masterclass series. IN THIS EPISODE YOU WILL LEARN: What are lipids, and why are they important? Dr. Dayspring explains what triglycerides are. How lipids get absorbed and transported throughout the body What lipoproteins are, and how they get classified How cholesterols get calculated The impact of triglycerides on cholesterol levels and cardiovascular health How high triglyceride levels can indicate early insulin resistance or increased ASCVD risk What is the role of HDL particles? How metabolic syndrome impacts cardiovascular health Bio: Thomas Dayspring MD is a Fellow of both the American College of Physicians and the National Lipid Association and is certified in internal medicine and clinical lipidology. After practicing in New Jersey for 37 years, in 2012, he moved to Virginia. He served as an educational director for a nonprofit cardiovascular foundation and until mid-2019 as a Chief Academic Advisor for two major CV laboratories. Since then, he has served as a virtual cardiovascular / lipidology educator. Career-wise he has given over 4000 domestic (in all 50 states) and several international lectures, including over 600 CME programs on atherothrombosis, lipids/lipoproteins (and their treatment), vascular biology, biomarker testing, and women's cardiovascular issues. He has authored several manuscripts and lipid textbook chapters and performed several podcasts. For several years he was an Associate Editor of the Journal of Clinical Lipidology. He was the recipient of the 2011 National Lipid Association's Presidents Award for services to clinical lipidology and the 2023 Foundation of NLA Clinician/Educator Award. He has over 34K followers on his educational Twitter (X) feed (@Drlipid). He has Gold Heart Member status as a professional member of the American Heart Association and serves as a Social Media Ambassador for the European Atherosclerosis Society and the National Lipid Association. Connect with Cynthia Thurlow Follow on Twitter, Instagram & LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Connect with Dr. Thomas Dayspring Twitter (@DrLipid) LinkedIn