Podcasts about Metabolomics

  “Your DNA

In today's episode of The Root Cause Medicine Podcast, Dr. Lauren Hernandez and Dr. Devan Szczepanski join Dr. Kate Kresge to explore: 1. How to identify early signs of chronic illness in children 2. Why traditional pediatric testing often misses crucial health markers that could prevent chronic conditions 3. The "Triangle of Health" framework for pediatric functional medicine 4. How to use genetic testing to determine the most appropriate formula and dietary choices for infants and young children 5. Why conventional approaches to ADHD, anxiety, and digestive issues may be missing underlying genetic and metabolic factors Dr. Lauren Hernandez and Dr. Devan Szczepanski are pioneering practitioners at NuWell Medicine, where Dr. Hernandez serves as CMO of KidsWell, their specialized pediatric service line. With vast backgrounds in pediatric medicine, they have developed an innovative "triangle of health" approach that combines comprehensive blood work, metabolic, gut microbiome analysis, and genomic testing to provide personalized care for children. Their work has transformed traditional pediatric practice by incorporating functional medicine principles and precision testing to address chronic childhood conditions before they become severe health challenges. Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide

Could an essential fatty acid discovered in Navy dolphins unlock the secret to healthier aging? In this episode of Longevity Roadmap, Dr. Stephanie Venn-Watson reveals the groundbreaking science behind C15, an essential fatty acid linked to longevity and reduced disease risk. Learn how metabolomics uncovered the connection between higher C15 levels and healthier dolphins—and why this matters for humans. Dr. Venn-Watson explains how C15 deficiency can accelerate aging, increase the risk of fatty liver disease, and contribute to cellular fragility syndrome and ferroptosis, a newly discovered form of cell death linked to iron overload. We dive into clinical trials on C15 supplementation, its impressive health benefits, and why this saturated fat may be a game-changer for nutrition and aging. Discover why dolphin research is reshaping our understanding of essential fatty acids and why C15 could be the key to addressing the silent epidemic of C15 deficiency. Whether you're interested in longevity, epidemiological studies, or cutting-edge clinical trials, this episode offers actionable insights into the future of health and nutrition. Curious to learn more? Grab Dr. Venn-Watson's new book, The Longevity Nutrient: The Unexpected Fat That Holds the Key to Healthy Aging, and explore the groundbreaking science behind C15 and its potential to revolutionize your health: https://fatty15.com/ Ready to experience the benefits of C15 yourself? Dr. Venn-Watson is offering our audience an exclusive 20% off your first order at: fatty15.com/LONGEVITYROADMAP

Send us a textDr. Dimitris Tsoukalas MD, PhD is a Board-Certified Family Physician, the Scientific Director of the Metabolomic Medicine® Medical Group, President of European Institute of Molecular Medicine, and an Associate Member of the World Academy of Sciences.Dr. Dimitris Tsoukalas is a medical doctor and scientific director of Metabolomic Medicine® medical group, with clinics in Athens Greece and , Milan Italy. He is a pioneer in the prevention and treatment of autoimmune and chronic conditions such as Hashimoto's thyroiditis, rheumatoid arthritis, diabetes, systemic lupus erythematosus, multiple sclerosis, psoriasis, Crohn's disease, and ulcerative colitis, using Metabolomic Analysis®.Metabolomic Analysis® detects deficiencies in micronutrients and the metabolic causes of autoimmune and chronic diseases. He is also the author of the best-selling book How to Live 150 Years in Health.He has published more than 50 scientific studies and is a keynote speaker at international medical conferences for the detection of metabolic disorders and micronutrient deficiencies related to preventing and treating autoimmune and chronic diseases.Find Dr. Tsoukalas at-https://www.drtsoukalas.com/Find Boundless Body at- myboundlessbody.com Book a session with us here!

Dr. Boros holds a Doctor of Medicine (M. D.) degree from the Albert Szent-Györgyi School of Medicine, Szeged, Hungary and is a retired Professor of Pediatrics, Endocrinology and Metabolism of the University of California Los Angeles (UCLA) School of Medicine. Dr. Boros is the co-inventor of the stable isotope-based dynamic metabolic profiling (SIDMAP) technology, which is a functional biochemistry tool used for detailed biochemical and deutenomics related drug testing, library screening, lead optimization and in vitro and in vivo phenotype profiling. The core technology involves studying natural and disease/drug induced variations in stable non-radiating stable 13C (carbon) and 2H (deuterium) isotope distribution patterns and cross talk among metabolites in living systems. He also established mitochondrial quantum vacuum as the prime driving force of all life related energy producing biochemical events. These occur via the quantum destabilization of hydrogen ions, i. e. protons, in structured water of mitochondrial nano-confinements that are compromised by deuterium; hence the regulation of deuterium (deutenomics, human deutenome project) is a critical process to maintain health and longevity.Dr. Boros trained as a house staff in his medical school in gastroenterology after receiving a research training fellowship from the Hungarian Academy of Sciences.  Dr. Boros was a visiting Scholar at the Essen School of Medicine in Germany and also worked as a Research Scientist at the Ohio State University, Department of Surgery.  Dr. Boros is the recipient of the C. Williams Hall Outstanding Publication Award from the Academy of Surgical Research of the United States (1997), the Richard E. Weitzman Memorial Research Award from the University of California (2001), the Excellence in Clinical Research Award from the General Clinical Research Center at the Harbor-UCLA Medical Center (2004) and Public Health Impact Investigator Award of the United States Food and Drug Administration (2011).  Dr. Boros serves as an associate editor for the journals Springer Nature- Scientific Reports, Medicine, Pancreas, Molecules and Metabolomics.SHOWNOTES:

☕ Coffee & Gut Microbiome

When you hear the word “metabolism,” you might think of calories or basal metabolic rate—the energy your body needs to survive. But metabolism is much more than that. It's a complex network of processes influenced by your diet, lifestyle, sleep, exercise, and stress, impacting nearly every part of your physical and mental health. This week, we hear from an academic researcher whose groundbreaking work in metabolomics sheds light on the deeper science of metabolism and its far-reaching implications for health and wellness. Listen and learn: Why metabolism is about more than just calories The hidden complexities of your digestive system and its impact on health How artificial intelligence is transforming scientific research into metabolism The exciting future of vaccines and their role in metabolic health Why fears surrounding GMO foods are often based on myths, not facts How metabolomics is paving the way for innovative health interventions Link ABOUT OUR GUEST Oliver Fiehn is a professor of molecular and cellular biology at the University of California, Davis, and director of the Fiehn Lab and the West Coast Metabolomics Center. A pioneer in metabolomics, he has authored over 450 publications and is renowned for advancing analytical chemistry and bioinformatics to study metabolism in health and disease.  Like the Show? Leave us a review Check out our YouTube channel  

We're witnessing an exciting shift in how we understand gut health and disease—and it's all thanks to the powerful metabolites produced by the microbiome, like short-chain fatty acids (SCFAs) and secondary bile acids. In today's episode, Dr. Tom Fabian shares groundbreaking insights into how these postbiotics influence intestinal barrier integrity, immune balance, and even muscle regeneration. These compounds are also connected to key processes like glucose metabolism and healthy aging. What's truly fascinating is how this science is opening up new frontiers in treating IBS, metabolic conditions, and chronic gut issues. With the upcoming launch of Diagnostic Solution Laboratories' StoolOMX test, an add-on to the GI-MAP, we now have a tool to measure these metabolites in clinical practice, making personalized and effective treatments more attainable. This is a pivotal moment in functional medicine that you don't want to miss. ~DrKF FOLLOW ALONG WITH THE CONVERSATION! Get the Updated GI-MAP® Guide with StoolOMX™ Insights! The new GI-MAP® Guide now includes StoolOMX™ insights on bile acids and short-chain fatty acids, enhancing your understanding of IBS, IBD, and gut motility. Refine treatment strategies and optimize patient care with this essential resource. Download now! https://tinyurl.com/5ehysjp7 Check out the show notes at https://tinyurl.com/2t55s3y3 for the full list of links and resources. GUEST DETAILS Thomas Fabian, PhD, CNTP Email: tom.fabian@diagnosticsolutionslab.com Dr. Fabian is a leading expert on the role of the microbiome in health, immune function, chronic disease, and aging. As a translational scientist, his primary focus is on the clinical application of microbiome research in the integrative and functional medicine space. He received his PhD in molecular biology from the University of Colorado, Boulder, and has worked as a biomedical researcher in the biotechnology industry, and more recently, as a consultant in the microbiome testing field. Currently, Dr. Fabian serves a consultant and science advisor with Diagnostic Solutions Laboratory, and he is also a Science Advisory Board member with Designs for Health. In addition, he is certified as a Nutrition Therapy Practitioner by the Nutrition Therapy Institute in Denver. THANKS TO OUR SPONSOR Diagnostic Solutions Laboratory: https://www.diagnosticsolutionslab.com/ Phone: 877-485-5336 CONNECT WITH DrKF Want more? Join our newsletter here: https://www.drkarafitzgerald.com/newsletter/ Or take our pop quiz and test your BioAge! https://www.drkarafitzgerald.com/bioagequiz YouTube: https://tinyurl.com/hjpc8daz Instagram: https://www.instagram.com/drkarafitzgerald/ Facebook: https://www.facebook.com/DrKaraFitzgerald/ DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: https://tinyurl.com/yx4fjhkb Younger You book: https://tinyurl.com/mr4d9tym Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw

Commentary by Dr. Jan Leerink.

In this episode of the Smarter Not Harder Podcast, the HOMeHOPe team recaps the key health trends and significant moments of 2024. Featuring Jodi Duval, Dr. Ted Achacoso, Boomer Anderson, and Dr. Scott Sherr, the discussion covers complex adaptive systems, metabolomics, the FDA's stance on MDMA, and the rise and challenges of GLP-1s in obesity management. They also delve into the evolving mental health landscape, the role of GABA, and the advancements in AI.  Join us as we delve into: + The evolving world of psychedelics + Health and technology trends on the rise + Building a global community of health professionals + The crossroads of disease treatment & health optimization This episode is for you if: - You're fascinated by the role of AI in advancing healthcare - You're intrigued by the evolution of mental health discourse post-COVID - You're keen to explore metabolomics and health optimization medicine - You're interested in understanding the impact of psychedelics in medical practice You can also find this episode on… YouTube: https://youtu.be/UkwDpJ-ztJQ Find more from Smarter Not Harder: Website: https://troscriptions.com/blogs/podcast | https://homehope.org Instagram: @troscriptions | @homehopeorg Get 10% Off your purchase of the Metabolomics Module by using PODCAST10 at https://www.homehope.org Get 10% Off your Troscriptions purchase by using POD10 at https://www.troscriptions.com Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.

Join us as we explore the **7 Pillars of Health**, a comprehensive framework that integrates various innovative health disciplines including Metabolomics, Epigenetics, Bioenergetics, the Gut Immune System, Exposomics, Evolutionary Biology and Chronobiology. Dr. Jill Carnahan and Dr. Ten Achacoso share their expertise and provide actionable insights on how these pillars work together to create a robust and resilient health system.

Have you ever felt like your skin has lost its vitality, no matter how many products you try? The answer might not be on the surface—it could be deep within your cells.In this episode of Biohacking Beauty, I'm joined by Dr. Scott Sherr and we'll uncover how mitochondrial dysfunction, often caused by hidden lifestyle imbalances, could be silently accelerating skin aging. From diminishing elasticity to a dull complexion, your skin's struggles may all trace back to cellular health.Dr. Sherr and I also explore how HBOT and advanced supplements like methylene blue work synergistically to optimize cellular health, reduce oxidative stress, and boost energy production. We talk about the power of troches and other approaches to address stress, inflammation, and mitochondrial function in ways that typical supplements can't.If you're interested in cutting-edge strategies that go beyond skincare to truly impact your cellular health and longevity, this episode is for you.Dr. Scott Sherr is a thought leader in the fields of hyperbaric medicine and metabolomics, integrating science-backed treatments for enhanced cellular and mitochondrial function. As co-founder of the Health Optimization Medicine and Practice (HOME|HOPE) nonprofit, he educates practitioners on leveraging metabolomics for personalized, whole-body wellness strategies.We Also Discuss:(00:01) Conducting Health Optimization and Biohacking(08:18) Precision Skincare and Metabolomics(19:16) Understanding Mitochondrial Function and Dysfunction(28:14) Hyperbaric Oxygen Therapy for Anti-Aging(40:27) Benefits of Trochies for Precision Dosage(46:26) Methylene Blue and Trochies Discussion(59:07) Optimizing Health and Performance StacksLearn More AboutYoung GooseUse code PODCAST10 to get 10% off your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/ Learn More About Dr. Scott SherrWebsite: https://www.hyperbaricmedicalsolutions.com/ Instagram: https://www.instagram.com/hmshbot Youtube: https://www.youtube.com/user/HyperbaricMS

The NIEHS Superfund Research Program (SRP) is hosting a Risk e-Learning webinar series focused on using artificial intelligence (AI) and machine learning to advance environmental health research. The series will feature SRP-funded researchers, collaborators, and other subject-matter experts who aim to better understand and address environmental health issues by applying AI and machine learning approaches to complex issues. Recent advances in AI and machine learning methods show promise to improve the accuracy and efficiency of environmental health research. Over the course of three sessions, presenters will discuss how they use AI and machine learning approaches to improve chemical analysis, characterize chemical risk, understand microbial ecosystems, develop technologies for contaminant removal, and more. In the third and final session, ML & AI Applications to Understand Omics, Metabolomics, & Immunotoxicity and Optimize Bioengineering Using Datasets, Models, and Mass Spectrometry, speakers will discuss how they apply machine learning and artificial intelligence tools to analyze mass spectrometry and microscopy data and optimize models for understanding metabolomics, metabolite pathways, and immunotoxicology To learn about and register for the other sessions in this webinar series, please see the SRP website. Grace Peng, Ph.D., is a co-coordinator of the National Institutes of Health (NIH) Common Fund's Bridge to Artificial Intelligence (Bridge2AI) program, bridging the gap between the biomedical, behavioral and bioethics research communities and the data science/AI communities through a consortium of diverse experts to set the stage for widespread adoption of AI/ML in medicine. Dr. Peng will give an overview of the Bridge2AI program and introduce one of their projects at the University of California San Diego — Trey Ideker, Ph.D. Dr. Ideker will discuss the cell maps for AI (CM4AI) functional genomics project, one of four major data generation projects under the Bridge2AI program. The goal of the project is to provide a comprehensive map of human cellular components through generation of major spatial proteomics datasets. John Efromson, M.S., will present on Ramona Optic, Inc.'s Multi-Camera Array Microscope [MCAM(TM)], which is used to automate imaging and computer vision analysis of zebrafish and greatly improves previous throughput and analysis capabilities. Multiple applications of machine learning will be discussed, including behavioral pose estimation and phenotyping, morphological analysis, and cell counting and fluorescence quantification, as well as how these distinct analyses can be used together for pharmacology, toxicology, and neuroscience research. Speakers:Grace C.Y. Peng, Ph.D., Division of Discovery Science and Technology (Bioengineering), National Institute of Biomedical Imaging and Bioengineering and Trey Ideker, Ph.D., University of California San DiegoJohn Efromson, M.S., Ramona OpticsForest White, Ph.D., Massachusetts Institute of Technology (MIT)Moderator: Hunter Moseley, Ph.D., University of Kentucky To view this archive online or download the slides associated with this seminar, please visit http://www.clu-in.org/conf/tio/SRP-ML-AI3_112224/

The NIEHS Superfund Research Program (SRP) is hosting a Risk e-Learning webinar series focused on using artificial intelligence (AI) and machine learning to advance environmental health research. The series will feature SRP-funded researchers, collaborators, and other subject-matter experts who aim to better understand and address environmental health issues by applying AI and machine learning approaches to complex issues. Recent advances in AI and machine learning methods show promise to improve the accuracy and efficiency of environmental health research. Over the course of three sessions, presenters will discuss how they use AI and machine learning approaches to improve chemical analysis, characterize chemical risk, understand microbial ecosystems, develop technologies for contaminant removal, and more. In the third and final session, ML & AI Applications to Understand Omics, Metabolomics, & Immunotoxicity and Optimize Bioengineering Using Datasets, Models, and Mass Spectrometry, speakers will discuss how they apply machine learning and artificial intelligence tools to analyze mass spectrometry and microscopy data and optimize models for understanding metabolomics, metabolite pathways, and immunotoxicology To learn about and register for the other sessions in this webinar series, please see the SRP website. Grace Peng, Ph.D., is a co-coordinator of the National Institutes of Health (NIH) Common Fund's Bridge to Artificial Intelligence (Bridge2AI) program, bridging the gap between the biomedical, behavioral and bioethics research communities and the data science/AI communities through a consortium of diverse experts to set the stage for widespread adoption of AI/ML in medicine. Dr. Peng will give an overview of the Bridge2AI program and introduce one of their projects at the University of California San Diego — Trey Ideker, Ph.D. Dr. Ideker will discuss the cell maps for AI (CM4AI) functional genomics project, one of four major data generation projects under the Bridge2AI program. The goal of the project is to provide a comprehensive map of human cellular components through generation of major spatial proteomics datasets. John Efromson, M.S., will present on Ramona Optic, Inc.'s Multi-Camera Array Microscope [MCAM(TM)], which is used to automate imaging and computer vision analysis of zebrafish and greatly improves previous throughput and analysis capabilities. Multiple applications of machine learning will be discussed, including behavioral pose estimation and phenotyping, morphological analysis, and cell counting and fluorescence quantification, as well as how these distinct analyses can be used together for pharmacology, toxicology, and neuroscience research. Speakers:Grace C.Y. Peng, Ph.D., Division of Discovery Science and Technology (Bioengineering), National Institute of Biomedical Imaging and Bioengineering and Trey Ideker, Ph.D., University of California San DiegoJohn Efromson, M.S., Ramona OpticsForest White, Ph.D., Massachusetts Institute of Technology (MIT)Moderator: Hunter Moseley, Ph.D., University of Kentucky To view this archive online or download the slides associated with this seminar, please visit http://www.clu-in.org/conf/tio/SRP-ML-AI3_112224/

Matters Microbial #61: All In Due Time–How Bacteria Wake from Dormancy October 17, 2024 Today, Dr. Paul Carini, of the Environmental Science department of the University of Arizona, joins the #QualityQuorum to discuss how soil bacteria can become dormant, “wake up,” and why that is more relevant than you might suppose. Host: Mark O. Martin Guest: Paul Carini Subscribe: Apple Podcasts, Spotify Become a patron of Matters Microbial! Links for this episode A lovely essay about the “Cultivation Conundrum”:  why so many microbes in nature cannot be grown in the laboratory. The “uncultivated majority” is often called “microbial dark matter,” described here.   An essay about the scale of microbiology with some fascinating facts. Arizona Culture Collection project by Dr. Carini and colleagues. Dilution to extinction technique An overview of sporulation, including some fascinating variations. A description of Arthrobacter A description of Bradyrhizobium An essay explaining PCA plots An essay about intrinsically disordered proteins A very nice video about working in Dr. Carini's lab.  HIGHLY RECOMMENDED. Dr. Carini's faculty website. Dr. Carini's fascinating laboratory website. Dr. Carini's Substack page, where he explores many microbiological ideas. Intro music is by Reber Clark Send your questions and comments to mattersmicrobial@gmail.com

It's time to light up our mouths! In today's episode, we cover research and information centered around the impact of mitochondrial function on oral health and oral diseases along with photobiomodulation research on how red and blue light therapy can impact oral health.​​As we know from our past episodes with biological dentists (shoutout to Dr. Kelly Blodgett and Dr. Dominik Nischwitz), the impact of your oral health is not relegated to just your oral cavity  — it literally impacts every system and every organ in your body. Optimizing your oral health may be the easiest and most effective way to improve your systemic health!​​I will also be officially introducing BioLight newest (and potentially most impactful) product to date: the Illume sonic toothbrush! The Illume incorporates red and blue LEDs that allows you to irradiate your teeth, gums and other oral tissues. There are many research-backed benefits of red and blue light for oral health: anti-inflammatory, pro-circulatory, mitochondrial-boosting, anti-bacterial/anti-microbial (i.e. improving oral microbiome), enamel erosion-mitigating, biofilm- and bad breath-reducing and much more! If you found the information in today's episode particularly interesting and/or compelling, please share it with a family member, friend, colleague and/or anyone that you think could benefit and be illuminated by this knowledge. Sharing is caring :)As always, light up your health! - Key Points: [00:00] Introduction to Red Light Therapy & Podcast Overview[00:13] Mitochondrial Triad: Red Light Therapy, Methylene Blue, and C60[00:36] Special Announcement: BioLight's New Product[01:06] Benefits of BioLight's New Device for Daily Use[01:21] Upcoming Methylene Blue Product Launch[02:09] Addressing Common Issues with Methylene Blue[02:49] Previews of the Exciting New Features Coming in September[03:03] BioLight Illume: A New Sonic Toothbrush with Red and Blue LEDs[03:36] Benefits of Red and Blue Light for Oral Health[04:13] Comparison of Illume Toothbrush vs. Guardian+[04:40] Features of the BioLite Illume Sonic Toothbrush[05:47] Red and Blue Light: Benefits for Oral Microbiome and Health[07:07] Oral Health and Systemic Wellness[07:33] Introduction to Holistic Dentistry and Upcoming Guests[08:22] BioLight Illume: A Tool for Everyday Wellness[09:06] Mitochondrial Function and Oral Health: Scientific Insights[10:38] The Role of Mitochondria in Oral Health and Disease[12:26] Periodontitis: Link to Systemic Diseases[13:41] Mitochondrial Dynamics and Oral Health[17:40] Mitophagy and Mitochondrial Biogenesis[19:58] Oxidative Stress and Mitochondrial Function[20:34] Metabolomics and Mitochondrial Dysfunction[20:58] Mitochondrial Function in Oral Health [23:41] Biological Dentistry & Mitochondria [25:20] Benefits of Red Light Therapy for Oral Health [27:26] Pre-, During, and Post-Procedure Red Light Therapy[29:15] Low-Level Laser Therapy vs. LED Red Light Therapy [31:26] Red Light Therapy's Role in Reducing Enamel Erosion[34:24] Canker Sore & Orthodontic Treatment Benefits [36:46] Antibacterial Effects of Red and Blue Light [38:59] Red Light as Preventative Care [39:59] Blue Light Therapy for Teeth Whitening & Antimicrobial Effects [40:09] Blue Light Therapy Benefits[41:02] Summary of Red & Blue Light Therapy[42:01] Comparing Guardian+ and Illume Toothbrush[43:24] Low and Slow Approach for Illume[44:43] Practical Benefits of Red and Blue Light in Toothbrush[45:29] Future Conversations on Biological Dentistry[46:00] Personal Red Light Therapy Practices[47:12] Brightness of Illume Toothbrush[47:57] Guardian for Intense Oral Issues[49:01] Listener Questions and Future Content[49:38] Discount for Illume Toothbrush Pre-Orders[50:22] Oral Health and Mitochondrial Health - Introducing the BioLight Illume! BioLight's patent-pending technology brings the power of red and blue LEDs into a sonic toothbrush. Now your mouth can receive the many benefits of red and blue light!   For the month of September, preorder your Illume toothbrush with a 15% discount — simply use discount code "preorder"   To light up your smile, click here - Dr. Mike's #1 recommendations: Water products: Water & Wellness Grounding products: Earthing.com EMF-mitigating products: Somavedic Blue light-blocking glasses: Ra Optics - Stay up-to-date on social media: Dr. Mike Belkowski: Instagram LinkedIn   BioLight: Website Instagram YouTube Facebook

Dr. Stephanie Venn-Watson is the CEO of Seraphina Therapeutics. A seasoned veterinary epidemiologist and public health scientist, Stephanie previously served at the World Health Organization and U.S. Navy. With a life-long mission of helping people (and our fellow animals) age better, Stephanie's award-winning approach to improving human and animal health has been featured on NPR, BBC, CBS, and National Geographic. In her time as CEO, Seraphina Therapeutics has been recognized for its extensive research and education on pentadecanoic acid (C15:0).Stephanie received her B.S. in Animal Physiology and Neuroscience from UC San Diego, D.V.M. from Tufts University, M.P.H. from Emory University, and was a National Research Council Associate with the Armed Forces Medical Intelligence Center. She is an Albert Schweitzer Fellow for Life. SHOWNOTES:

Have you ever wondered if there was a way to gain deep insights into your body's unique needs and optimize your health? The answer may lie in the cutting-edge field of metabolomics.   In today's episode of the Longevity Podcast, Dr. Paniz Jasbi, the co-founder of Theriome, and I discuss how their groundbreaking Aristotle test is revolutionizing the way we approach health and wellness. From assessing mitochondrial function and nutritional status to identifying potential disease risks and guiding personalized interventions, the Aristotle test is a game-changer for precision medicine. Overall, we discuss this test's ability to offer valuable insights for dealing with complex health issues, recovering from illness, or optimizing your athletic performance.   Dr. Paniz Jasbi founded Theriome in 2022. Integrating the theory of –omics sciences, Theriome seeks to innovate personalized wellness by analyzing the totality of systems biology—from the genome to the metabolome, and everything in between.   Use code NAT to save when ordering the Theriome metabolomic test for 10% off. Shop here: https://therio.me/      Thank you to our sponsors for making this episode possible: Vitali: Visit https://www.vitaliskincare.com/discount/Nathalie20 and use code Nathalie20 to save on your order. Mitopure: Use code NAT10 for 10% off your order at https://www.timelinenutrition.com/shop/nutrition Berkeley Life: Consumers may register and place an order using my code NIDDBL for 10% off at berkeleylife.com   Find more from Dr. Paniz Jasbi:  Website: https://therio.me/    Instagram: @theriometest   Book: Theriome and the Aristotle Test   Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ  Join Nat's Membership Community: https://www.natniddam.com/bsp-community  Sign up for Nats Newsletter: https://landing.mailerlite.com/webforms/landing/i7d5m0  Instagram: https://www.instagram.com/nathalieniddam/  Website: www.NatNiddam.com    Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance  What We Discuss:  04:30 Understanding the Omics 09:58 Leveraging AI in Metabolomics 19:25 The Microbiome and ILIA Test 23:35 Exploring Spermidine and Other Metabolites 45:41 The Importance of Directly Assessing Mitochondrial Function 50:08 The Implications of Disease Enrichment Analysis 52:56 The Importance of Access to Personal Health Information 01:07:24 The Accessibility and Affordability of the Test  

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Iñigo San-Millán is an internationally renowned applied physiologist and a previous guest on The Drive. His research and clinical work focuses on exercise-related metabolism, metabolic health, diabetes, cancer metabolism, nutrition, sports performance, and critical care. In this episode, Iñigo describes how his work with Tour de France winner Tadej Pogačar has provided insights into the amazing potential of elite athletes from a performance and metabolic perspective. He speaks specifically about lactate levels, fat oxidation, how carbohydrates in food can affect our lactate and how equal lactate outputs between an athlete and a metabolically unhealthy individual can mean different things. Next, he discusses how Zone 2 training boosts mitochondrial function and impacts longevity. He explains the different metrics for assessing one's Zone 2 threshold and describes the optimal dose, frequency, duration, and type of exercise for Zone 2. Additionally, he offers his thoughts on how to incorporate high intensity training (Zone 5) to optimize health, as well as the potential of metformin and NAD to boost mitochondrial health. Finally, he discusses insights he's gathered from studying the mitochondria of long COVID patients in the ICU. We discuss: The amazing potential of cyclist Tadej Pogačar [2:00]; Metrics for assessing athletic performance in cyclists and how that impacts race strategy [7:30]; The impact of performance-enhancing drugs and the potential for transparency into athletes' data during competition [16:15]; Tadej Pogačar's race strategy and mindset at the Tour de France [23:15]; Defining Zone 2, fat oxidation, and how they are measured [26:00]; Using fat and carbohydrate utilization to calculate the mitochondrial function and metabolic flexibility [35:00]; Lactate levels and fat oxidation as it relates to Zone 2 exercise [39:15]; How moderately active individuals should train to improve metabolic function and maximize mitochondrial performance [51:00]; Bioenergetics of the cell and what is different in elite athletes [56:30]; How the level of carbohydrate in the diet and ketogenic diets affects fuel utilization and power output during exercise [1:07:45]; Glutamine as a source for making glycogen—insights from studying the altered metabolism of ICU patients [1:14:15]; How exercise mobilizes glucose transporters—an important factor in diabetic patients [1:20:15]; Metrics for finding Zone 2 threshold—lactate, heart rate, and more [1:24:00]; Optimal Zone 2 training: dose, frequency, duration, and type of exercise [1:40:30]; How to incorporate high intensity training (Zone 5) to increase VO2 max and optimize fitness [1:50:30]; Compounding benefits of Zone 2 exercise and how we can improve metabolic health into old age [2:01:00]; The effects of metformin, NAD, and supplements on mitochondrial function [2:04:30]; The role of lactate and exercise in cancer [2:12:45]; How assessing metabolic parameters in long COVID patients provides insights into this disease [2:18:30]; The advantages of using cellular surrogates of metabolism instead of VO2 max for prescribing exercise [2:25:00]; Metabolomics reveals how cellular metabolism is altered in sedentary individuals [2:33:00]; Cellular changes in the metabolism of people with diabetes and metabolic syndrome [2:38:30]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

On this episode of JHLT: The Podcast, the JHLT Digital Media Editors explore two studies from the May issue of The Journal of Heart and Lung Transplantation. Digital Media Editor David Schibilsky, MD, a cardiothoracic surgeon from Freiburg, Germany, hosts this episode.   First, Dr. Schibilsky and Digital Media Editor Erika Lease, MD, interview their first guest, Helen A. Hannan, the podcast's first-ever undergraduate pre-medical guest, from the University of Michigan. Helen was the lead author on the study “Racial and Gender Disparities in Transplantation of Hepatitis C+ Hearts and Lungs.” The study noted that prior research in utilization of kidneys from donors with Hepatitis C had shown disparities due to gender and education—and wanted to see if this was the case in heart and lung donors as well.   Drs. Schibilsky and Lease chat with Helen about the findings of the study, including some of the interesting differences shown between heart and lung recipients, and the ramifications for better patient discussions at the clinical level.   Next, Dr. Schibilsky and Digital Media Editor Marty Tam, MD, interview their next guest, Lauren Truby, MD, of the University of Texas Southwestern Medical Center in Dallas. Dr. Truby is the podcast's first return guest, having appeared on the show near the end of 2021. This time, she's featured as first author on the study “Metabolomic profiling during ex situ normothermic perfusion before heart transplantation defines patterns of substrate utilization and correlates with markers of allograft injury.” The paper explores cardiac metabolism of donor hearts during recovery using an ex situ normothermic perfusion system (NRP).   Dr. Truby provides an in depth look at the project's logistics—which she calls a “labor of love”—its multi-point findings, and what's next in this line of research.   Follow along at www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt.   Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.    

We know that there are a billion people in the world with undiagnosed obstructive sleep apnea (OSA) and that it simply isn't practical to have every person undergo a sleep study. Are there other methods that might be more efficient identifying those at the highest risk of OSA? Dr. Laura Castillo is a chemist who has studied biological matrices to identify biomarkers for obstructive sleep apnea. Her research involves analyzing sweat and she has found that there are specific markers for those with severe OSA and those without any OSA. Dr. David Gozal has been working in this field for many years and has published extensively. He has also studied urine proteomics as a method to identify sleep disordered breathing in children.

BUFFALO, NY- April 9, 2024 – A new #researchpaper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 6, entitled, “CMS121: a novel approach to mitigate aging-related obesity and metabolic dysfunction.” Modulated by differences in genetic and environmental factors, laboratory mice often show progressive weight gain, eventually leading to obesity and metabolic dyshomeostasis. The geroneuroprotector CMS121 has a positive effect on energy metabolism in a mouse model of type 2 diabetes. In this new study, researchers Alcir L. Dafre, Saadia Zahid, Jessica Jorge Probst, Antonio Currais, Jingting Yu, David Schubert, and Pamela Maher from Salk Institute for Biological Studies, National University of Sciences and Technology (NUST) and Federal University of Santa Catarina investigated the potential of CMS121 to counteract the metabolic changes observed during the ageing process of wild type mice. “This comprehensive analysis aimed to further understand how CMS121 influences the metabolic landscape, paving the way for potential therapeutic applications beyond its established geroneuroprotective benefits.” Control or CMS121-containing diets were supplied ad libitum for 6 months, and mice were sacrificed at the age of 7 months. Blood, adipose tissue, and liver were analyzed for glucose, lipids, and protein markers of energy metabolism. The CMS121 diet induced a 40% decrease in body weight gain and improved both glucose and lipid indexes. Lower levels of hepatic caspase 1, caspase 3, and NOX4 were observed with CMS121 indicating a lower liver inflammatory status. Adipose tissue from CMS121-treated mice showed increased levels of the transcription factors Nrf1 and TFAM, as well as markers of mitochondrial electron transport complexes, levels of GLUT4 and a higher resting metabolic rate. Metabolomic analysis revealed elevated plasma concentrations of short chain acylcarnitines and butyrate metabolites in mice treated with CMS121. “The diminished de novo lipogenesis, which is associated with increased acetyl-CoA, acylcarnitine, and butyrate metabolite levels, could contribute to safeguarding not only the peripheral system but also the aging brain. By mimicking the effects of ketogenic diets, CMS121 holds promise for metabolic diseases such as obesity and diabetes, since these diets are hard to follow over the long term.” DOI - https://doi.org/10.18632/aging.205673 Corresponding authors - Pamela Maher - pmaher@salk.edu and Alcir L. Dafre - alcir.dafre@ufsc.br Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205673 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts About Aging-US Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer's diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases. Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

In this episode of the Smarter Not Harder Podcast, Dr. Ted Achacoso, a pioneer in Health Optimization Medicine and Practice (HOMe/HOPe), dives into the revolutionary perspective of health as an active, ongoing process rather than simply the absence of disease. *Join us as we delve into:* + The Cell Danger Response (CDR): How it drives our body's reactions to stress, both internal and external. + Multi-omics approaches: The tools (like clinical metabolomics) that uncover imbalances before major diseases manifest. + Evolutionary medicine: Understanding our health needs in the modern world based on how our bodies evolved. + The importance of balance: Fine-tuning nutrition, inflammation, and other key systems for true health, not just feeling "not sick" This episode is for you if: - You're interested in proactive approaches to health and longevity. - You want to understand the cutting-edge science behind optimizing your well-being. - You're frustrated with traditional medical approaches that focus solely on treating symptoms. - You're curious about how your environment, diet, and even mindset influence your health at the cellular level.

I'm excited to share a little bit about the upcoming Hack Your Health event that I'll be speaking at. Please join me in welcoming Robin Switzer, the CEO of the event. At the Hack Your Health event, I'm going to share fascinating information about the following topics: 1. Cancer 2. The autoimmune disease epidemic 3. The heart's response to nutrition 4. Metabolomics Metabolomics allows a practitioner to look deeper at your biochemistry beyond a standard blood test. Metabolomics provides a bigger picture and is a better strategy for creating health than the standard healthcare model. It can help predict your risk for chronic illnesses like diabetes two decades before they develop. Misdiagnosis is a common problem people experience when seeking answers about their symptoms. Metabolomics can help reduce misdiagnosis by looking at specific biomarkers to understand precisely what the problem is. The Hack Your Health event will be held in Austin, TX, May 31-June 2. A general admission ticket is $299.00, but it's discounted to $249.00 for the Dr. Berg community. The goal of the event is to educate as many people as possible! The Hack Your Health event aims to educate people about more than just diet! I hope to see you there.

Is genetic testing a future key indicator for achieving optimal skin health? With the emergence of cutting-edge software, we now can minimize the guesswork regarding our generic insights. However, it is not a foolproof system… yet, as there is a vital difference between data-driven health solutions and faulty tests. In this episode of the Biohacking Beauty podcast, Amitay, CEO of Young Goose, catches up with Joe Cohen, the founder of Self Decode, to discuss the evolution of personal health optimization through data analysis and technology. Hear from Joe as he recounts his own experiences with self-experimentation and how it paved the way for improved health.Listen as Amitay and Joe discuss the intricacies of genetic testing and metabolomics, as well as how important real-time data can craft individualized health strategies. Joe Cohen is recognized as a biohacker and entrepreneur who has helped over 150,000+ customers achieve optimal health using the most advanced genetic analysis. What we discuss: (1:30) Growing up with health problems and biohacking (15:22) Experimenting with your health and trusting the data(23:23) What is Self Decode and how it can help identify opportunities in your health(31:49) The snipping of genetic code and why you should proceed with caution(37:02) Why supplements are not the answer to your health problems(43:50) The dimensions of mapping your goals and using genetic testing to achieve them(53:38) How genetic testing can impact skin health(1:06:57) Metabolomics and amino acids, and the role they play in your health(1:19:12) Health education and the gap within the healthcare systemTo learn more about Young Goose:Use code PODCAST10 to get 10% off your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/Instagram: @young_goose_skincareTo learn more about Joe Cohen:Instagram: https://www.instagram.com/mrbiohacker/?hl=enSelf Decode: https://selfdecode.com/?utm_source=Instagram&utm_medium=joe_social&utm_campaign=linkinbio&nab=1&utm_referrer=https%3A%2F%2Flinktr.ee%2FResources:Spermidine research: https://www.longevitybioresearch.org/Spermidine in health and disease: https://www.science.org/doi/10.1126/science.aan2788

Dan Kalish, DC, IFMCP, is the founder of the Kalish Institute For Functional Medicine, an online practice implementation training program dedicated to building Integrative and Functional Medicine practices through clinical and business courses. He has trained over 7,000 practitioners in building successful functional medicine practices. The Kalish Institute teaches clinical application and patient communication techniques through a hands-on, case-based approach.  Dr. Kalish has published a research study on his clinical methods with the Mayo Clinic and is the author of three books on functional medicine.   Together Dr. Kalish and I discuss metabolomics and organic acids testing. He simplifies the complex concepts of organic acids testing, who it would be best for, and how practitioners can incorporate these concepts into their practice. He highlights the four main areas that are included in metabolomic and organic acids tests, the key markers of the tests, and the main deficiencies that are better addressed by these tests over a micronutrient panel.  Our conversation touches on the Krebs cycle, carnitine deficiencies, and practitioner limitations in understanding various pathways. Dan offers recommendations for practitioners to sequentially structure a supplement program and shares information regarding panels, tests that indicate healthy neurotransmitter function, and cortisol insights.  His approach is practical, inspiring, and encouraging for practitioners who are interested in metabolomics and organic acids testing and need to know where to start. I'm your host, Evelyne Lambrecht, thank you for designing a well world with us. Key Takeaways: [2:28] Dr. Kalish offers an overview of his journey in this field and his passion for teaching it to other practitioners. [4:19] The four main areas that are included in metabolomic and organic acids tests, and common patient issues and symptoms that indicate the need for the test. [8:44] Key markers in the test, including lactic and pyruvic acids, and main deficiencies that are addressed in this test versus a micronutrient panel. [13:42] Overcoming the practitioner's limitations of understanding the intricacies of various pathways, including Dan's favorite pathway beta-oxidation. [19:25] Potential underlying reasons and resulting defects for carnitine deficiencies. [22:34] The most relevant steps in the Krebs cycle in a metabolomic test. [25:04] Common results and recommendations from the individual markers of the metabolomic test. [31:08] The critical role of supplementing with B vitamins in the Krebs cycle. [34:18] Timelines for realizing expected results in patients and the longevity of the vitamin effectiveness. [37:56] Dan's recommendations for practitioners to sequentially structure a supplement program. [40:15] Markers on organic acids and metabolomic tests that indicate healthy neurotransmitter function and cortisol. [44:25] The full salivary adrenal panel covers three tests and three body systems including HPA analysis or salivary cortisol testing, GI testing, and organic acids testing. [45:35] Determining whether high neurotransmitter markers are clearance issues or issues of being too high starts with acquiring the learning of markers. [51:12] Final questions regarding quinolinic acid and other organic acids. [56:00] How to connect with Dr. Kalish, his changed perspective on microbiome health, and his go-to supplements and health practices.   Episode Resources: Dr. Dan Kalish Design for Health Resources: Designs for Health Spotlight™ Functional Wellness Tests Webinar: Spotlight Suite Functional Wellness Tests Blog: Optimizing Micronutrient Status for Energy Metabolism Research Blog: B Vitamins and Overall Stress Response Research Blog: The Latest on Magnesium for Healthy Blood Sugar Support Science Update: Recent Review Explores Potential Relationship Between Magnesium Status and Cardiometabolic Health Visit the Designs for Health Research and Education Library which houses medical journals, protocols, webinars, and our blog.

Dr. Eric Berg is a well-respected pioneer in keto and low-carb circles. He's a man who's been there almost from the beginning. So, rather than just cover old ground, we venture into the controversies and pushback from those industries that are threatened by the metabolic health movement.  As it turns out, it seems the rise of keto threatens the economic biases and informational control exerted by powerful food companies. Who knew?In our conversation, we venture into the heart of the global dietary debate, where the tension between corporate interests and individual health is palpable.  Dr. Berg breaks down the complexities of the battle. On one side, the protein-centric ketogenic diet. On the other, the corporate-backed dietary guidelines that favor grains and sugars. The implications are vast. We touch on public health, the medical establishment, and of course, Big Pharma.Finally, our conversation looks to the future of health and nutrition, with Metabolomics and personalized medicine taking center stage. Dr. Berg advances the revolutionary idea that healthcare should enhance our natural vitality, not merely manage disease. -------------Connect with Dr. Eric BergWebsiteLinkTreeTwitter ===================== Chances are, you wouldn't be listening to this podcast if you didn't need to change your life and get healthier. So take action right now. Book a call with Dr. Ovadia's team. One small step in the right direction is all it takes to get started. How to connect with Stay Off My Operating Table:Twitter: Dr. Ovadia: @iFixHearts Jack Heald: @JackHeald5 Learn more: Learn more about Dr. Ovadia's personalized health coaching Get Dr. Ovadia's book Stay Off My Operating Table on Amazon. Take Dr. Ovadia's metabolic health quiz: iFixHearts visit Dr. Ovadia's website: Ovadia Heart Health visit Jack Heald's website: CultYourBrand.com Theme Song : Rage AgainstWritten & Performed by Logan Gritton & Colin Gailey(c) 2016 Mercury Retro Recordings

Join me, Dr. Mike T Nelson, on the Flex Diet Podcast, where we explore the intricate connections between gut health and exercise performance. In this conversation with Dr. Sarah Campbell, we expand upon the influence of antibiotics on aerobic performance, delving into how hydration and different types of water can impact your gut microbiota. We also discuss the often-overlooked oral microbiome, examining its interactions with pre-workout supplements and mouthwashes, and consider environmental factors such as fluoride on our internal ecosystems. Tune in for a blend of personal insights and scientific discussions as I share updates from my time in El Cuyo, Mexico, and Dr. Campbell teases her upcoming adventures in Peru.For Dr Campbell's top 4 takeaways, go to https://miketnelson.com/flex4. Special thanks to Flex Diet Podcast sponsor LMNT. Choose LMNT for all your hydration needs. Check out https://drinklmnt.com/mikenelson.Episode Chapters:(0:00:01) - Gut Health and Exercise Performance(0:14:12) - Water, Microbiome, and Oral Health(0:22:12) - Oral Microbiome Studies and Findings(0:29:04) - Human Performance and Antibiotics Study(0:37:48) - Exploring Antibiotics and Performance Impact(0:47:13) - Troubles and Triumphs in Experimental Design(0:55:45) - Consumer Grade Gut Microbiome TestingConnect with Dr. Campbell:Dr. Campbell @ RutgersReferenced links:Flex Diet Podcast Episode 127: The Effect of Antibiotics on Muscle Mass, Aerobic/Cardiovascular Performance, and More – An Interview with Dr Sara CampbellAntibiotics and Aerobic Capacity by Paul Buono

In this podcast, we're going to talk about plant-based meat. Plant-based meat is marketed as clean meat. People are gravitating to these fake meats because of claims that real meat causes cancer and other chronic diseases. The studies that were used to draw these conclusions were food questionnaires and observational studies. Out of 800 studies on the topic, researchers claiming that meat was bad only focused on 17. An evaluation of the studies linking red meat to cancer by the Annals of Internal Medicine concluded that the evidence linking red meat consumption to cancer and cardiovascular disease is too weak to recommend that we eat less of it. New guidelines say we don't need to change our meat habits. No significant link between meat consumption and heart disease, diabetes, or cancer has been found. Plant-based meat is full of ultra-processed ingredients like seed oils, soy, modified food starches, and GMO ingredients. Claims that plant-based meat is identical to real meat are completely false. Metabolomic studies have shown key differences in 171 out of 190 compounds in fake meat compared to real meat.

Aging itself stands as the paramount driver of disease. As functional practitioners, the question arises: How can we assess biological age to make precise corrections that foster both healthspan and lifespan? Enter the era of omics, where metabolomics emerges as an exceptional tool with transformative potential. I'm thrilled to welcome back Dr. Betsy Redmond, longtime friend and the senior education specialist at Diagnostic Solutions Laboratory, to New Frontiers to lead us on this discussion.Together, we'll take a deep dive into specific metabolites and pathways intricately linked to aging, mood, inflammation, and gut health and you'll hear about equol, a rising star on the postbiotic scene. We'll even unravel some surprising insights from my own test results! Be sure to grab a copy of the Sample Report and pull up a seat for this fascinating discussion packed with valuable takeaways for yourself and your practice. ~DrKF You'll find it all at www.drkarafitzgerald.com/fxmed-podcast/

In this episode of the Smarter Not Harder Podcast, host Boomer Anderson is joined by guest Dr. Ted Achacoso to give one-cent solutions to life's $64,000 questions that include: What is the importance of understanding clinical metabolomics and measuring nutrient levels in the optimization of health, and how does this counter fear-based narratives surrounding multivitamin use and cancer risk? How does viewing health and illness at the right level, and understanding the role of vitamins, minerals, and cofactors in cancer treatment challenge conventional wisdom and contribute to a new perspective on health and wellness? How can a shift in mindset from the notion that supplements don't work to recognizing their essential role for overall health, as well as the concept of the body as a self-regulating ecosystem, encourage a fresh, informed approach to health?   What We Discuss: (0:04:03) - The need to understand clinical metabolomics levels for better health decisions   (0:18:21) - The survival instinct of cells and their link to cancer, and the use of vitamins and minerals in cancer treatment   (0:22:44) - The surprising truth of studies, emphasizing the role of education and the necessity to understand how studies work    (0:29:23) - Health optimization medicine and how body wisdom can be used for optimal health, and the importance of listening to our bodies and understanding individual needs through clinical metabolomics   Find more from Smarter Not Harder: Website: https://troscriptions.com/blogs/podcast | https://homehope.org Instagram: @troscriptions | @homehopeorg   Get 10% Off Your Purchase of the Metabolomics Module by using PODCAST10 at https://www.homehope.org   Get 10% Off your Troscriptions purchase by using POD10 at https://www.troscriptions.com   Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram.  

In this episode, we delve into the journey of Boomer Anderson, the CEO of Smarter Not Harder Inc., as he shares his transition from the fast-paced world of Wall Street to becoming a leading figure in the realm of health optimization. He provides invaluable tips for managing jet lag, drawing on his experiences traveling the globe. He emphasizes the importance of understanding one's individual biochemistry and tailoring approaches to health and wellness accordingly. We also discuss the concept of metabolomics, shedding light on how analyzing metabolic processes can guide personalized health decisions. Then we explore the latest sleep formula from Troscriptions, called Tro Zzz, and breakdown the fascinating ingredients in this unique formula.If curiosity killed the cat, Boomer's 9 lives expired decades ago. Boomer is an entrepreneur, husband, podcast host, health optimization practitioner, investor, and retired BBQ champion. Boomer is the CEO of Smarter Not Harder, Inc. makers of Troscriptions. He is also the CEO of Health Optimization Medicine and Practice, a 501(c)3 non-profit focused on educating doctors and practitioners on how to optimize for health rather than treat disease. In his own Health Optimization Practice, Boomer works with entrepreneurs leveraging large swaths of data and health technology. He also serves as a Strategic Advisor to Welldium and is a TEDx Speaker.CEO, Smarter Not Harder Inc. makers of TroscriptionsCEO, Health Optimization Medicine and PracticeTEDx SpeakerSHOW NOTES:0:51 Welcome to the show!2:40 Today's Takeaways5:58 Boomer Anderson's Bio7:13 Welcome him to the podcast8:19 How he crashed and burned on Wall Street15:52 Subjective vs Objective Biofeedback18:31 His lowest hanging fruit20:18 What is Metabolomics?27:48 Top Tips for Jet Lag32:33 * Private MD Labs *34:42 Blue Cannatine36:37 Supplement & Tool Graveyard38:51 * BiOptimizers MEGA Sale *40:52 Minimum Effective Metrics44:23 First Night Effect46:12 When & how to use supplements48:49 Troscriptions Formulations53:03 Santa Claus & Amanita Mushrooms1:01:18 Honokiol, Adenosine & GABA1:04:48 Bioindividual approach to sleep1:09:08 Words of caution1:12:20 Effects of Alcohol & Sleep1:16:20 Buccal troche absorption methods1:20:11 His final piece of advice1:21:33 Thanks for tuning in!RESOURCES:Troscriptions: Instagram, TikTok, Website, LinkedIn, X, YouTubeDiscount Code: BIOHACKERBABESHOMeHOPe: Instagram, Website, LinkedIn, X, YouTubeBoomer Anderson: Instagram, LinkedIn Private MD Labs - With Private MD Labs, you can order your labs online without having to visit a doctor or answer any uncomfortable questions. It's super easy, and during Cyber Monday, you can get either a lifetime package for $699 or simply order any of their tests at 27% off.BiOptimizers - Discount code: BIOHACKERBABES10Support this podcast at — https://redcircle.com/biohacker-babes-podcast/donationsAdvertising Inquiries: https://redcircle.com/brands

Dr. Arthur M. Lee provides an overview of the results of his study, "Circulating Metabolomic Associations with Neurocognitive Outcomes in Pediatric CKD," on behalf of his colleagues.

Wellness + Wisdom | Episode 585 Is laser therapy the solution to chronic pain? Forrest Smith, CEO and Co-Founder of Kineon Labs, joins Josh Trent on the Wellness + Wisdom podcast, episode 585, to share how photobiomodulation can revolutionize chronic pain healing, why chronic pain is a sign of inflammation, and how laser and red light therapy work for healing joint pain and damaged tissue. "If you've got a fire in your kitchen and the house is burning down, you have inflammation and pain in your joints. The pain is the signal, the sound coming from that fire alarm. The fire in the kitchen is the inflammation. And what we see people doing with with opiates and anti-inflammatory drugs, is taking the batteries out of the fire alarm so that they can't hear this anymore but the fire's still going." - Forrest Smith 10% Off Kineon Red light therapy for fast relief from joint pain and inflammation 10% Off with code "JOSH10" The MOVE+ Pro is a safe, non-invasive, enhanced light therapy device. The next generation of laser light technology to help relieve joint pain, reduce inflammation, and stimulate the healing of damaged tissues. The combination of highly-targeted LED and laser technology allows the light to reach deeper into the joint, for more effective results. Each of the three modules has 8 x deep red (650nm) LEDs and 10 x Infrared (808nm) laser diodes. In a single 5-minute session, MOVE+ Pro activates and increases blood flow, reducing inflammation and pain — our customers report an 80% reduction in pain within 1-4 weeks. In This Episode, Forrest Smith Uncovers: [01:30] LED + Laser Light Technology for Chronic Pain Forrest Smith Kineon - 10% off with code "JOSH10" 525 Red Light Therapy For Seasonal Affective Disorder (SAD) | Brian Richards Why we should listen to our pain instead of numbing it with drugs. The reason why older people don't trust new technology. How the healthcare system should focus on prevention. Dementia is caused by inflammation. [10:40] How to Measure Physical Pain Lauren Colletti The tests you can take to optimize your health. WAVi Brain Scan Why standard pain measurement is subjective. Electromagnetic scans are currently the most efficient tool to measure pain. The technology Kineon has developed and why they believe silicon photomultiplier is the future. [18:30] Chronic Pain = Chronic Inflammation 581 Healthspan Revolution: Game-Changing Biomarker Blood Testing (SiPhox) | Michael Dubrovsky How lack of movement is correlated to depression and chronic anxiety. Why pain is just a signal of chronic inflammation. How traumatic tissue damage causes local chronic inflammation. What the shear strength test measures. [25:45] The Science of Photobiomodulation Why people shouldn't correlate their pain with their age. The difference between getting sunlight and photobiomodulation. How most red light therapy devices are not efficient in treating joint pain. The relation between blood vessels and inflammation. Why very high and very low oxidative stress is not good for you. [33:45] The Benefits of Laser Therapy The difference between chronic and acute inflammation. 388 Dr. Jud Brewer | Unwinding Anxiety: New Science Shows How to Break the Cycles of Worry and Fear to Heal Your Mind Why the dosage of photobiomodulation devices is important. The purpose of photobiomodulation panels. How Kineon helps you remodel soft tissue and increase your cell stems. [41:50] How Kineon Changes Lives How they monitor tissue healing with Kineon. The short-term and long-term effects of using the device. Exercise brings oxidative stress to your body in a healthy amount. Why Forrest loves hearing the stories of people whose life was changed using Kineon. How they stay true to their mission. [51:00] Are You Self-Sabotaging Your Wellness Journey? 541 Genetic Liberation: How To Increase Your Vitality With The Secrets of “MANNA” Unlocked How we unconsciously sabotage ourselves. Why medical professionals love using Kineon. How healing yourself can help heal the world. How chronic pain takes away your power. [01:00:30] How to Use Kineon for Best Results Solving problems takes energy. Dr. Tim Brown How Kineon helps heal edema. Why remodeling soft tissue takes time. How often you should use Kineon to achieve results. Laser therapy increases collagen production and helps heal scars. [01:09:15] Healing Scar Tissue with Laser Therapy How Kineon can heal your old tissue damage. Why the blood flow in old scars is lower. You can measure blood flow using your phone and Kineon. Unpacking if technology can potentially heal on a level we never even imagined. Many behavioral pathologies are based on metabolic health. [01:17:05] Laser Technology Evolution for Health + Wellness How remote photobiomodulation works. The new Kineon device using Metabolomics that will be released soon. Why laser technology is getting cheaper. The reason why Forrest sees laser therapy as an alternative to pharmaceuticals. [01:22:05] The Current Situation in China Why Josh believes China is a focal point for demonic energy in the world. Forrest's experience living in China for 20 years. Why he enjoys living in Mexico now. What has been happening in China since the pandemic. How ghost cities were created in China. [01:35:00] Creating a Change in The World Why Forrest is optimistic about the future of technology. How the overload of information makes it more difficult to filter it. Turning optimism into empowerment and using information to change the world. Why Kineon provides a money-back guarantee and customer support. Leave Wellness + Wisdom a Review on Apple Podcasts Limited Edition: Gold Pumpkin Spice from Organifi Save 20% with code "WELLNESSFORCE" on everyone's favorite Fall treat is here! Pumpkin Spice is more than just a taste phenomenon: it's a portal directly into the nostalgia of fall. With Gold Pumpkin Spice, that taste can also help promote relaxation and restful sleep, nourish the body, and support nightly recovery from a hard day's work.  Click HERE to order your Organifi today including the Green, Red, and traditional Gold! Are You Stressed Out Lately? Take a deep breath with the M21™ wellness guide: a simple yet powerful 21 minute morning system that melts stress and gives you more energy through 6 science-backed practices and breathwork. Click HERE to download for free. Biohack Your Mind & Body with Plunge Ice Baths!Save $150 on your PLUNGE order with code "WELLNESSFORCE" As seen on Shark Tank, Plunge's revolutionary Cold Plunge uses powerful cooling, filtration, and sanitation to give you cold, clean water whenever you want it, making it far superior to an ice bath or chest freezer. *Review The Wellness + Wisdom Podcast & WIN $150 in wellness prizes! *Join The Facebook Group Power Quotes From The Show Tissue Damage Affects The Heart "There was a 3,500 player study with the NFL players. 50% had ACL tears, 50% didn't. The 50% that had the ACL tears had a greater than 50% increase in severe cardiovascular disease. You have increased chronic inflammation in that joint almost forever after that traumatic tissue damage that you have with the injury and then the surgery. And it impacts and impairs your cardiovascular endothelial tissue." - Forrest Smith Healthcare Is Actually Semi-Care "The most profitable way to run a pharmaceutical company is to keep people in a state of semi-health, provide them some benefits, but never get them well. The pharmaceutical industry has spent billions of dollars developing different solutions that would keep people in that most profitable role of the commercialization, which is in semi-health and semi-sickness. That's the most valuable customer to have. What's not a valuable customer to have is somebody that you can provide preventative measures to." - Forrest Smith Inflammation Impacts Your Entire Body "When you measure the temperature of the muscle above the unhealthy joint, it's 1 to 2 degrees colder than the one above the healthy joint. That's severely impacting the amount of oxygen and blood delivery to that tissue. Local inflammation impacts degrading tissue, tearing down your cartilage, making you have worse outcomes from a mobility standpoint. And then you go regional and you look at the muscle tissue and it's getting worse blood delivery, worse oxygen delivery. And you go systemic and you look at endothelial cardiovascular tissue and the sheer strength is dropping. This is something that's impacting you across all of these different parts of your body." - Forrest Smith Movement + Mental Health "When you can't or don't move, your joints just get worse and worse. And it's extremely highly correlated to depression, increased chronic anxiety, and a lot of neurological impacts because of lack of movement." - Forrest Smith Photobiomodulation Research Photobiomodulation (PBM) research - a comprehensive database Photobiomodulation or low-level laser therapy The Efficacy of Photobiomodulation Therapy in Improving Tissue Resilience and Healing of Radiation Skin Damage Photobiomodulation—Underlying Mechanism and Clinical Applications Is It Time to Consider Photobiomodulation As a Drug Equivalent? Photobiomodulation for the treatment of neuroinflammation: A systematic review of controlled laboratory animal studies Shining light on the head: Photobiomodulation for brain disorders Links From Today's Show  Forrest Smith Kineon - 10% off with code "JOSH10" 525 Red Light Therapy For Seasonal Affective Disorder (SAD) | Brian Richards Lauren Colletti WAVi Brain Scan 581 Healthspan Revolution: Game-Changing Biomarker Blood Testing (SiPhox) | Michael Dubrovsky 388 Dr. Jud Brewer | Unwinding Anxiety: New Science Shows How to Break the Cycles of Worry and Fear to Heal Your Mind 541 Genetic Liberation: How To Increase Your Vitality With The Secrets of “MANNA” Unlocked Dr. Tim Brown Josh's Trusted Products | Up To 40% Off Shop All Products BREATHE - 33% off with the code “PODCAST33” Organifi –20% off with the code ‘WELLNESSFORCE' SiPhox - Save 10% with code "JOSH" Holy Hydrogen - Save $100 with code "JOSH" SinuSonic - Save 15% with "JOSH15" QI-Shield EMF Device- 20% off with the code "JOSH" SimplyO3 - Save 10% with "JOSH10" SEED Synbiotic - 30% off with the code "JOSHTRENT" BON CHARGE - 15% off with the code "JOSH15" MANNA Vitality - 20% off with the code "JOSH20" Mendi.io - 20% off with the code "JOSH20" SpectraSculpt - 15% off with the code "JOSH15" SaunaSpace - 10% off with the code "JOSH10" Cured Nutrition CBD - 20% off with the code "WELLNESS FORCE" PLUNGE - $150 off with the code “WELLNESSFORCE" LiftMode - 10% off with the code "JOSH10" MitoZen – 10% off with the code “WELLNESSFORCE” Adapt Naturals - Save 15% with code "WELLNESSFORCE" Paleovalley – 15% off with the link only NOOTOPIA - 10% off with the code "JOSH10" Activation Products - 20% off with the code “WELLNESSFORCE” SENSATE - $25 off with the code "JOSH25" BiOptimizers - 10% off with the code "JOSH10" ION - 15% off with the code ‘JOSH1KS' Feel Free from Botanic Tonics - $40 off with the code "WELLNESS40" Essential Oil Wizardry - 10% off with the code "WELLNESSFORCE" ALIVE WATERS - 33% off your first order with the code "JOSH33" DRY FARM WINES - Get an extra bottle of Pure Natural Wine with your order for just 1¢ Drink LMNT – Zero Sugar Hydration: Get your free LMNT Sample Pack, with any purchase Earth Runner Shoes - Save 10% with code "JOSH10" Free Resources M21 Wellness Guide - Free 3-Week Breathwork Program with Josh Trent Join Wellness + Wisdom Community About Forrest Smith Forrest Smith is the CEO of Kineon Labs. He is a dynamic entrepreneur and esteemed leader in the tech hardware industry, bringing to the table an impressive 20-year track record of creating and scaling successful startups. His career trajectory at Kineon Labs stands as a testament to his unwavering optimism and innovative approach in the field of health and wellness technology. An avid sports enthusiast, Forrest's competitive spirit was honed on the fields of Atlanta, where he played various sports and continues to actively participate in rugby matches and CrossFit training. This athletic passion was the catalyst for the conception of the Knee+ enhanced light therapy device, a key offering from Reviiv Light that embodies his commitment to health and fitness. From the age of 14, Forrest has cultivated a deep fascination for Chinese culture and language, a passion that has grown into fluency and profound professional expertise in the Asian market. His 18 years of experience in startup creation and executive management in Asia have been marked by considerable success. In 2000, Forrest embarked on his first entrepreneurial journey in China with a fabric-sourcing company, which was later acquired in 2002. Over the next decade, he demonstrated his exceptional aptitude for business development and leadership, founding and directing a series of companies, including Source Pro Asia, August Vale, and Illumitron. Each venture flourished under his guidance, leading to acquisition by larger corporations, such as Wilway Holdings and Cooper Lighting. Website Instagram Facebook YouTube Listen To The Latest Episodes... Don't Miss New Episodes: Follow Wellness + Wisdom on Spotify  

The word metabolomics may not mean much to you right now, but it may just be the future of medicine. Today's guest is here to demystify this emerging field of science and show how it can help usher in a more precise version of personalized medicine.This is the Story of Theriome with Dr. Paniz Jasbi.EPISODE VIDEO HIGHLIGHTSWatch the Entire EpisodeThe Power of Metabolomics in Personalized HealthcareMetabolomics Testing Redefined: The Evolution of the AristotleConsumer and Medical Community Response to Theriome's Metabolomics TestThe Aristotle Test: A Deep Dive Into Your Health DataTransparency, Technology, and Trust in Health TestingUnlocking the Potential of AI for Better HealthcareTaking Microbiome Testing to the Next LevelTheriome's Role in Shaping the Future of HealthCONNECT WITH DR. PANIZ JASBIWebsite - TheriomeInstagramFacebook YouTubeLinkedInTikTokCONNECT WITH INNOVATIVE MEDICINE Website Instagram Facebook YouTube CONNECT WITH CASPAR SZULC Instagram Twitter LinkedIn LEARN ABOUT NADOVIM - A BREAKTHROUGH IN BRAIN HEALTHDoctor-formulated, clinically-tested true NAD+ supplement for focus, concentration and cognitive support. Visit our website and save 10% on your first order by using coupon code NADOVIM10. Website Instagram Facebook 'YOUR HEALTH. YOUR STORY.' PODCAST Follow us on Spotify Follow us on iTunes Subscribe on ...

In this episode, Jonathan is joined by Brian Van Tine, Professor of Medicine in medical oncology and Professor of Paediatrics at the Washington University School of Medicine (WUSM) in St. Louis, Missouri, USA, to provide an overview of his clinical interest in soft tissue and bone sarcomas. The pair explore immunotherapy, specifically monoclonal antibodies and immune checkpoint blockade, and further dive into metabolomics and its relevance to oncology.   Use the following timestamps to navigate the content in this episode:  (00:00)-Introduction  (03:50)-Brian's inspiration for pursuing oncology  (04:43)-The rare tumour world and sarcomas  (06:13)-Immunotherapy trials (09:21)-Treatment options for advanced alveolar soft part sarcoma  (13:52)-Genetic mutations in malignant diseases  (17:13)-Argininosuccinate synthetase 1 (22:49)-Metabolomics (25:55)-Anthracycline-associated cardiotoxicity in patients with soft tissue sarcoma  (28:40)-Treatments available for soft tissue tumours  (31:49)-Three wishes

My guests today are movement specialist and head of programming at XPT/Fitlab, Mr. PJ Nestler, and CEO of PN Medical, which developed the breathing tool Breather Fit, Mr. Mark Carbone. We talk about all things breathing and have a well-rounded conversation about best practices for breathing on your own or if you have a device. We learn how we should breathe when we are recovering from an athletic performance or dealing with stress. PJ and Mark's deep understanding of breathing, and how to incorporate techniques into your day-to-day life, provide so many useful takeaways, no matter what your objectives are. Enjoy! Show Sponsors: Quince: Go to Quince.com/gabby for free shipping on your order and 365-day returns.  Vionic: Use code GABBY at checkout for 15% off your entire order at www.vionicshoes.com when you log into your account. 1 time use only. Connect with Mark: Website: PN Medical - Home of The Breather and Breather Fit Bio: Mark loves "10x Thinking"​ and "what if"​ and "why not"​ people. He's passionate about the future of Digital Health and working towards breakthrough solutions to further the medical industry in Metabolomics, Pulmonary Therapy and Speech Pathology. He's an inventor, business builder, technologist, and a blessed husband and father. He is the CEO of PN Medical, makers of intelligent medical devices for the pulmonary and speech fields. He serves as lead inventor overseeing creation of their new device and software, Breather 2. He's also chief visionary, recruiter, deal maker, and leader of the company. He received his BA from UCF and MBA from Rollins College. Mark is also a Lifework Leadership alum, founder of the Rollins Business Journal, Dream Builder, medical device inventor, was VP of the Rollins MBA Alumni Board, soccer player, and nominated as Most Influential Businessman by the Orlando Business Journal. Connect with PJ: @coachpjnestler  Websites: XPTLife.com Fitlab.com Bio: Meet Coach PJ Nestler, a human performance specialist with over a decade of experience preparing top athletes for competition. His life mission is to help athletes and coaches realize their true potential. With a passion for sports and a commitment to excellence, PJ has become a leader in sports performance training. He has trained dozens of athletes from the NFL, NHL and MLB and has worked extensively with over 100 fighters, including multiple Brazilian Jiu-Jitsu World Champions and Top 10 ranked UFC fighters. Through the application of his progressive training philosophy and unique approach to every situation, Coach PJ continues to raise the bar for fitness professionals. He has emerged as a sought-after expert in human performance and trainer education.  Connect with Gabby @gabbyreece | Linktree For the full show notes visit gabriellereece.com/podcast The Gabby Reece Show talks to top experts with the goal of extracting the best information you will need to navigate the universe of health, fitness, relationships, parenting, and business. Gabby keeps it simple but gets to the heart of the conversation with the hopes of providing you with realistic takeaways. Learn more about your ad choices. Visit megaphone.fm/adchoices

Metabolomics is a scientific study that provides real-time snapshots of our physiology and health. This revolutionary field offers a unique insight into our bodies, enabling us to understand our health and nutritional habits like never before. In this episode of the Biohacking Beauty podcast, host Amitay Eshel, the CEO of Young Goose, is joined by Dr. Paniz Jasbi, Founder and Chief Science Officer of Theriome, a biotech company that leverages innovative science, cutting-edge technology, and advanced bioinformatics for breakthroughs in health and wellness research. We explore the revolution of personalized medicine through metabolomics. Dr. Jasbi shares his work at Theriome and how the Aristotle metabolomics test is paving the way for a brighter future for health, including the intricate connection between our unique metabolomic blueprints, health, and skin vitality.What we discuss:03:23 - What is Metabolomics Testing?13:06 - How does a metabolomics test give you personalized health recommendations from big data?22:47 - What is the basis of good integumentary health (overall health of the skin, hair, nails, and teeth)?30:55 - What does the information from the Environmental Toxin Exposure Score give us insight into?39:00 - The future of metabolomics testing45:12 - The future of metabolomics and health and beauty57:00 - How to get the Aristotle test?To learn more about Young Goose:Website: https://www.younggoose.com/Instagram: @young_goose_skincareGet 20% off your first purchase by using code PODCAST20 at www.younggoose.comTo learn more about Dr. Paniz Jasbi:Twitter: https://twitter.com/DrJasbiWebsite: https://shop.mytheriome.com/

This week my guest is Dr. Paniz Jasbi, CEO of Theriome, a trailblazing company at the forefront of metabolomics research. In this conversation, we delve deep into the world of metabolomics, uncovering the fascinating science behind how metabolism impacts every facet of our health, far beyond the narrow lens of weight loss. Join us as Dr. Jasbi takes us on a journey through the groundbreaking work of Theriome, shedding light on how their pioneering research is revolutionizing our understanding of human health. From decoding the intricacies of metabolic pathways to exploring the potential applications in precision medicine, this episode promises to expand your horizons on the pivotal role metabolism plays in our well-being. If you're curious about the cutting-edge science that's reshaping the future of healthcare and the profound implications it holds for your own health journey, don't miss this insightful conversation with Dr. Paniz Jasbi. It's time to rethink what metabolism truly means for our overall health. Connect with Dr. Jasbi https://therio.me/pages/about-us  info@therio.me  Instagram @theriometest Facebook @Theriome LinkedIn @theriome Connect with Liz Instagram @motherhoodunstressed hello@motherhoodunstressed.com Web: https://www.motherhoodunstressed.com 

Zenith All Natural Fat Burning Supplement Buy Zenith here Awakendnation.com/integrativematt Extra Zenith information: https://www.youtube.com/watch?v=igEyMcaCZDw https://www.youtube.com/watch?v=FSSZ-USzz3k https://www.youtube.com/watch?v=y9mkWri8TAw   Magnesium Breakthrough Use Code : integrativethoughts10 for 10% OFF https://bioptimizers.com/shop/products/magnesium-breakthrough   Just Thrive: Use Code ITP15 for 15% off https://justthrivehealth.com/discount/ITP15   Therasage: Use Code Coffman10 for 10% off https://www.therasage.com/discount/COFFMAN10?rfsn=6763480.4aed7f&utm_source=refersion&utm_medium=affiliate&utm_campaign=6763480.4aed7f   Nootopia: Use Code IntegrativeThoughts10 for 10% OFF https://nootopia.com/   Sleep Breakthrough: Use Code IntegrativeThoughts10 for 10% OFF https://bioptimizers.com/shop/products/sleep-breakthrough   Integrative Thoughts My Instagram: @integrativematt My Website: Integrativethoughts.com   Guest: Paniz Jasbi   Dr. Paniz Jasbi, PhD, is a leading figure in the realm of personalized medicine, pioneering breakthroughs in multi-omic testing and revolutionizing our understanding of biological health. Over the last decade, Dr. Jasbi has dedicated his research to exploring the intricate details of metabolism, genetics, and the microbiome. His transformative "Human Atlas Project" has paved the way for early disease detection, efficient and personalized treatment strategies, and a major shift towards proactive health maintenance. Rooted in a deep commitment to helping individuals gain access to critical health information on a molecular level, Dr. Jasbi's work stands at the forefront of a healthcare revolution. His innovations continue to guide us into the future of medicine, changing the face of healthcare and enhancing individual lives on a global scale. Website: https://therio.me/  Instagram: https://www.instagram.com/theriometest/ Facebook: https://www.facebook.com/Theriome/

E309– Inner Voice – a Heartfelt Chat with Dr. Foojan. In this episode, Dr. Foojan Zeine chats with Dr. Marcello (Giuseppe) Tanca. He has a Ph.D. In Neuroscience and is a Clinical Psychologist. He joins us from the Italian island of Sardinia, where he currently lives and works in his private practice performing: Psychodiagnosis, Psychotherapy, and Neuroscientific research. He was a visiting researcher at Stanford University, before going back to Italy to teach “Neuroscience and Psychodiagnosis” at the Psychotherapy Specialization School in Cagliari-Italy. As a researcher, he studies, in particular, the relationship between inflammatory processes and psychological/psychiatric symptoms. With research groups in the biomedical field that use cutting-edge approaches (such as Metabolomics and Artificial Neural Networks), he published research in international scientific journals, focused on “PANS”: "Pediatric Acute-Onset Neuropsychiatric Syndrome". PANS is a syndrome supported by the presence of an immune pathogenetic, based on dysregulation of the immune system, with its inflammatory correlates. Today we will be talking about his latest book, written in Italian, "Neuro-Inflammation and Dysfunction of Mental Processes - an introduction to the Importance of a new study perspective in Neuroscience". You may contact him at marcellotanca@hotmail.it Check out my website: www.FoojanZeine.com. Remember to Subscribe, Listen, Review, and Share! Find me on these sites: *iTunes (https://itunes.apple.com/us/podcast/i...) *Google Play (https://play.google.com/music/m/Inpl5...) *Stitcher (https://www.stitcher.com/s?fid=185544...) *YouTube (https://www.youtube.com/DrFoojanZeine ) Platforms to Like and Follow: *Facebook (https://www.facebook.com/DrFoojanZeine/) *Instagram (https://www.instagram.com/Dr.FoojanZe...) *Twitter (https://www.twitter.com/DrZeine/) *LinkedIn (https://www.linkedin.com/in/DrFoojanZ...)

Working towards breakthrough solutions to further the medical industry in Metabolomics, Pulmonary Therapy, and Speech Pathology. He's an inventor, business builder, technologist, and a blessed husband and father. He is the CEO of PN Medical, a maker of intelligent medical devices for the pulmonary and speech fields. He serves as lead inventor overseeing the creation of their new device and software, Breather 2. He's also the chief visionary, recruiter, deal maker, and leader of the company. He received his BA from UCF and MBA from Rollins College. Mark is also a Lifework Leadership alum, founder of the Rollins Business Journal, Dream Builder, medical device inventor, VP of the Rollins MBA Alumni Board, soccer player, and nominated as Most Influential Businessman by the Orlando Business Journal.

In this episode of the Smarter Not Harder podcast, we are joined by Dr. Ted Achacoso, the founding pioneer of the clinical practice of health optimization, medicine and practice and the Chief Science Officer of Smarter, Not Harder Inc. Listen along as Dr. Ted and host Boomer Anderson discuss metabolomics, your metabolome, genetic testing, and the health optimization medicine and practice framework.   What we discussed:   00:22 - About Dr. Ted Achacoso 4:00 - Why DNA isn't as important as we think 8:03 - Dangers of detoxification or genetic-based diets 10:00 - Nature vs. Nurture 15:30 - How metabolites help trace back autoimmune diseases 17:53 - Health Optimization Medicine and Practice  24:00 - Understanding the cell danger response 26:42 - The importance of Metabolomics 32:00 Quality vs Quantity of Life 34:28 - How metabolomics fits into the overall health optimization medicine practice 52:11 - What Made Dr. Ted formalize Health Optimization Medicine Education?   This podcast is brought to you by Health Optimization and Practice and Troscriptions, both founded by Smarter Not Harder Inc.    Get 10% Off Your Purchase of Metabolomics Module by using PODCAST10 at  https://www.homehope.org   Get 10% Off your Trosciptions purchase by using POD10 at https://www.troscriptions.com   Get daily content from the hosts of Smarter Not Harder by following @troscriptions on Instagram. 

Dr. Neil Kelleher is the Walter and Mary Elizabeth Glass Professor of Chemistry, Molecular Biosciences, and Medicine at Northwestern University. Neil is a protein biochemist. He weighs and analyzes proteins found in the human body, and he develops technology that allows scientists to measure new things. When he's not doing science, Neil likes to play basketball, and he has also been an avid golfer since he was young. He received his B.A. in chemistry from Pacific Lutheran University and his Ph.D. in chemistry from Cornell University. He conducted postdoctoral research at Harvard Medical School before joining the faculty at the University of Illinois in Urbana-Champaign. In 2010, he joined the faculty at Northwestern University. Neil has received numerous awards and honors over the course of his career, including the Biemann Medal of the American Society for Mass Spectrometry, the Presidential Early Career Award in Science and Engineering, the Camille Dreyfus Teacher-Scholar Award, the Cottrell Scholars Award, the Burroughs Wellcome Award in the Pharmacological Sciences, a CAREER award from the National Science Foundation, and others. In addition, he has received the Pittsburgh Conference Achievement Award, the Pfizer Award in Enzyme Chemistry, and the A.F. Findeis Award in Measurement Science from the American Chemical Society, Division of Analytical Chemistry. Neil was also a Becman Fellow, a Sloan Fellow, a Packard Fellow, a Searle Scholar, and a Fulbright Scholar. In our interview, Neil shares more about his life and science.

My guest this episode is Dr. Peter Attia, M.D., who trained at Stanford University School of Medicine, Johns Hopkins Hospital and the National Institutes of Health (NIH). Dr. Attia is host of The Drive podcast and is a world expert on behavioral approaches, nutritional interventions, supplementation and pharmacological techniques to improve lifespan, healthspan and athletic performance. We discuss how best to evaluate your health status using routine blood work, body scans and regular tests of physical strength and endurance. Dr. Attia explains what he uses with his patients to “back-cast” their health goals as a way to design their exercise and nutritional programs. We also discuss hormone modulation and replacement therapy for both men and women. We explain how cholesterol and related factors contribute to cardiovascular disease risk and how to monitor and mitigate that risk. Dr. Attia details various supplementation, nutrition, exercise and prescription approaches useful to people in every decade of life to improve vitality, reduce their risk of disease and increase the number of years sustaining peak cognitive and physical health.  Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman Thesis: https://takethesis.com/huberman InsideTracker: https://insidetracker.com/huberman Helix Sleep: https://helixsleep.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Assessing Health Status & Improving Vitality  (00:02:51) Momentous Supplements  (00:03:46) Thesis, InsideTracker, Helix Sleep  (00:07:29) Lifespan: Bloodwork & Biomarkers Testing, The “4 Horseman of Disease”  (00:11:51) Healthspan: Functional Testing, Cognitive & Emotional States  (00:13:59) Blood Testing: Best Frequency  (00:16:01) DEXA Scan: Lean Mass & Fat, Bone Mineral Density & Osteoporosis  (00:22:33) Bone Mineral Density & Age-Related Decline, Strength Training, Corticosteroids  (00:29:24) Osteopenia & Osteoporosis Diagnosis, Strength Training (00:31:03) AG1 (Athletic Greens) (00:32:16) Back-casting: Defining Your “Marginal Decade”  (00:38:31) All-Cause Mortality: Smoking, Strength, VO2 max  (00:44:43) Attia's Rule of Supplementation, “Centenarian Decathlete” Physical Goals (00:49:24) Importance of Exercise, Brain Health, MET hours  (00:55:23) Nicotine & Cognitive Focus (01:03:12) Menstruation, PMS & Menopause  (01:10:10) Hormone Replacement Therapy, Menopause & Breast Cancer Risk (01:22:06) Estrogen, Progesterone & Testosterone Therapies in Women (01:26:35) Hormone Replacement Therapy in Men, SHBG & Testosterone, Insulin (01:37:23) Clomid, Pituitary, Testosterone & Cholesterol, Anastrozole, HCG (01:47:46) Fadogia Agrestis, Supplements, Rapamycin  (01:52:06) Testosterone Replacement Therapy & Fertility  (01:59:26) Total Testosterone vs. Free Testosterone (02:02:51) Cholesterol & Dietary Cholesterol, Saturated Fat, LDL & HDL, Apolipoprotein B (02:17:42) Apolipoprotein B, Diet, Statins & Other Cholesterol Prescriptions  (02:25:15) Cardiovascular Disease, Age & Disease Risk  (02:28:53) Peptides, Stem Cells, BPC157, PRP (Platelet-Rich Plasma), Injury Rehabilitation  (02:37:40) Metabolomics & Exercise  (02:40:44) GLP-1 & Weight Loss  (02:47:06) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter, Huberman Lab Clips Title Card Photo Credit: Mike Blabac Disclaimer

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Josh Rabinowitz is a Professor of Chemistry and Integrative Genomics at Princeton University, where his research focuses on developing a quantitative, comprehensive understanding of cellular metabolism through the study of metabolites and their fluxes. In this episode, Josh focuses the discussion on three main topics: metabolomics, NAD (and its precursors), and cancer metabolism. The metabolomics discussion starts with a broad definition of metabolism, metabolites, and fluxomics before diving deep into glucose metabolism, lactate as a fuel, movement of lactate, and the regulation of these substrates. He then gives a detailed explanation of the electron transport chain and Krebs cycle and their implications with respect to both drugs and nutrition while also explaining how NAD is central to the process of energy generation. He then discusses the age-related decline in NAD and what current literature says about efforts to increase NAD through intravenous or oral supplementation with the precursors NMN and NR, including whether doing so provides any advantage to lifespan or healthspan. Finally, Josh ends the conversation talking about cancer metabolism and how one particular intersection between cancer metabolism and immunotherapy might provide a hopeful outlook on the future of cancer treatment. We discuss: Josh's background and unique path to becoming a research scientist at Princeton [3:30]; What sparked Josh's early interest in metabolism [11:15]; Metabolomics 101: defining metabolites and how they are regulated [16:30]; Fluxomics: metabolism as a system in action [26:00]; The Randle Hypothesis: glucose and fatty acids compete as substrates for oxidation [33:30]; The important role of lactate as an alternate fuel [36:30]; Fasting lactate levels as a potential early indicator of metabolic dysfunction [48:00]; The beauty of the Krebs cycle and the role of NAD in energy production [53:15]; How the drug metformin acts on complex I of the electron transport chain [1:05:00]; The difference between NADH and NADPH [1:08:45]; NAD levels with age, and the efficacy of supplementing with intravenous NAD [1:10:45]; The usefulness of restoring NAD levels and efficacy of oral supplementation with NAD precursors NR and NMN [1:22:15]; Exploring the hypothesis that boosting NAD levels is beneficial [1:32:30]; Cancer metabolism and the intersection with immunotherapy [1:39:00]; Making cancer a chronic disease: exploiting the metabolic quirks of cancer, augmenting the immune system, and more [1:46:15]; The challenge of treating pancreatic cancer [1:50:30]; Epithelial cancers that might respond to metabolic approaches to therapy [1:56:30]; Josh's hopeful outlook on the future of cancer treatment [1:59:00]; Nutritional approaches to cancer attenuation [2:00:15]; What makes Princeton University special [2:06:15]; More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Episode Description: Iñigo San-Millán is an internationally renowned applied physiologist and a previous guest on The Drive. His research and clinical work focuses on exercise-related metabolism, metabolic health, diabetes, cancer metabolism, nutrition, sports performance, and critical care. In this episode, Iñigo describes how his work with Tour de France winner Tadej Pogačar has provided insights into the amazing potential of elite athletes from a performance and metabolic perspective. He speaks specifically about lactate levels, fat oxidation, how carbohydrates in food can affect our lactate and how equal lactate outputs between an athlete and a metabolically unhealthy individual can mean different things. Next, he discusses how Zone 2 training boosts mitochondrial function and impacts longevity. He explains the different metrics for assessing one's Zone 2 threshold and describes the optimal dose, frequency, duration, and type of exercise for Zone 2. Additionally, he offers his thoughts on how to incorporate high intensity training (Zone 5) to optimize health, as well as the potential of metformin and NAD to boost mitochondrial health. Finally, he discusses insights he's gathered from studying the mitochondria of long COVID patients in the ICU. We discuss: The amazing potential of cyclist Tadej Pogačar [3:00]; Metrics for assessing athletic performance in cyclists and how that impacts race strategy [8:30]; The impact of performance-enhancing drugs and the potential for transparency into athletes' data during competition [17:00]; Tadej Pogačar's race strategy and mindset at the Tour de France [24:00]; Defining Zone 2, fat oxidation, and how they are measured [26:45]; Using fat and carbohydrate utilization to calculate mitochondrial function and metabolic flexibility [35:45]; Lactate levels and fat oxidation as it relates to Zone 2 exercise [40:00]; How moderately active individuals should train to improve metabolic function and maximize mitochondrial performance [51:45]; Bioenergetics of the cell and what is different in elite athletes [57:30]; How the level of carbohydrate in the diet affects fuel utilization and power output during exercise [1:08:30]; Glutamine as a source for making glycogen—insights from studying the altered metabolism of ICU patients [1:15:00]; How exercise mobilizes glucose transporters—an important factor in diabetic patients [1:21:00]; Metrics for finding Zone 2 threshold—lactate, heart rate, and more [1:25:00]; Optimal Zone 2 training: dose, frequency, duration, and type of exercise [1:41:15]; How to incorporate high intensity training (Zone 5) to increase VO2 max and optimize fitness [1:51:15]; Compounding benefits of Zone 2 exercise and how we can improve metabolic health into old age [2:01:45]; The effects of metformin, NAD, and supplements on mitochondrial function [2:05:15]; The role of lactate and exercise in cancer [2:13:30]; How assessing metabolic parameters in long COVID patients provides insights into this disease [2:19:00]; The advantages of using cellular surrogates of metabolism instead of VO2 max for prescribing exercise [2:25:45]; Metabolomics reveals how cellular metabolism is altered in sedentary individuals [2:33:45]; Cellular changes in the metabolism of people with diabetes and metabolic syndrome [2:39:15]; and More. Sign Up to Receive Peter's Weekly Newsletter Connect With Peter on Twitter, Instagram, Facebook and YouTube