Podcasts about Sharma

In this episode of the Epigenetics Podcast, we talked with Kunal Rai from MD Anderson Cancer Center about his work on active DNA demethylation and its role in cancer progression. A major part of the conversation covers his postdoctoral work on active DNA demethylation. He describes how he identified an AID-MBD4-based mechanism, later supported by GAD45, and how this work showed a role for DNA demethylation in early neuronal differentiation and in colon cancer initiation. We then discuss his move into his own lab and his work on melanoma progression. He explains how he used broad epigenomic profiling, chromatin state analysis, and 3D chromatin methods to study enhancers and chromatin organization, and how these approaches helped reveal changes linked to cancer progression. Another topic is his work on epigenetic regulators such as RNF2 and KMT2D. He describes findings on polycomb and trithorax-related factors, including tumor-suppressive roles for KMT2D in melanoma and lung cancer, and how KMT2D loss affects cell phenotype and metabolism. Finally, we talk about lab organization, collaboration, and newer technologies. He says his group works across multiple cancer types and increasingly includes immunology, single-cell methods, spatial epigenomics, and clinical translation, while still using ChIP-seq, CUT&RUN, and CUT&Tag where appropriate. References Fiziev, P., Akdemir, K. C., Miller, J. P., Keung, E. Z., Samant, N. S., Sharma, S., Natale, C. A., Terranova, C. J., Maitituoheti, M., Amin, S. B., Martinez-Ledesma, E., Dhamdhere, M., Axelrad, J. B., Shah, A., Cheng, C. S., Mahadeshwar, H., Seth, S., Barton, M. C., Protopopov, A., Tsai, K. Y., … Rai, K. (2017). Systematic Epigenomic Analysis Reveals Chromatin States Associated with Melanoma Progression. Cell reports, 19(4), 875–889. https://doi.org/10.1016/j.celrep.2017.03.078 Terranova, C. J., Tang, M., Maitituoheti, M., Raman, A. T., Ghosh, A. K., Schulz, J., Amin, S. B., Orouji, E., Tomczak, K., Sarkar, S., Oba, J., Creasy, C., Wu, C. J., Khan, S., Lazcano, R., Wani, K., Singh, A., Barrodia, P., Zhao, D., Chen, K., … Rai, K. (2021). Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy. Cell reports, 36(3), 109410. https://doi.org/10.1016/j.celrep.2021.109410 Related Episodes Epigenetic Signatures During Aging and Cancer (Alena van Bömmel) Epigenetic Mechanisms in Breast Cancer (Luca Magnani) The Effect of Histone Demethylases on Gene Expression and Cancer Cell Stability (Johnathan Whetstine) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com

Time Stamps:00:01:00 Intros00:00:35 Asha Sharma's NEW XBOX Is Treating Its Players Like 1st Class Gamers | Here's WHY It Matters!0045:00 The Games Media Is MAD That Gamers Are NOT Excited For Wolverine After The Previews Went LIVE!01:37:00 Outros and Special Message To The Community

TIME STAMP INFO:00:00:35 Intros00:07:00 Gears Of War E-Day Is One Of The MOST Important Moves Asha Sharma Has Made | Here's WHY!00:30:00 Asha Sharma Visited Bethesda and Saw The Elder Scrolls VI | XBOX's Next BIG Console Exclusive?01:07:00 Outros

In this episode with Sweekriti, we discuss her research on low back pain and using nudges to decrease low value care. We explore:The definition of a patient “nudge” and clinician “nudge"How to help people with LBP in the community before presenting to emergency departmentFurther research in managing low back painReducing alerts in EMR

In today's Daily Fix:Xbox CEO Asha Sharma has seen a "live playthrough" of The Elder Scrolls 6, and she teased not only the "scale and grandeur," but also the game's possible subtitle. She censored it with eight asterisks, which sent the internet into a frenzy trying to decode what it could possibly mean — likely a location, as is the trend with previous entries like The Elder Scrolls V: Skyrim. In other news, Ghost of Yōtei is getting a new expansion as part of a Complete Edition. The new story content, Echoes of Sekigahara, will be accompanied by a new survival mode. And finally, Disney has announced a Kingdom Hearts panel at their upcoming D23 fan convention. The panel will livestream this Friday at 4:30pm PT.

Twórcy Clair Obscur mówią, dlaczego uparli sięprzy pudełku, mimo że zarabiali na nim mniej, Unity buduje Netfliksowi własnąwersję silnika, ankieta na 3800 graczach pokazuje, przy której ocenie naSteamie połowa odbiorców odpada — a na koniec plan Ashy Sharmy, w którym Xboxma dogonić Sony i Nintendo na marżach do 2030 roku, plus wyciekłe dokumentypokazujące, jak zamierza to zrobić. 

What if belonging did not require us to arrive with all the answers?In this episode of Hearth 2 Heart, Gayathri Shukla sits down with Shivika Sharma, Investment Advisor at Sharma Wealth, Richardson Wealth, for a conversation about the pressure to appear knowledgeable, the dreams we quietly learn to dismiss, and what that reveals about the intserction between money and belonging.Together, Gayathri and Shivika explore a pattern that reaches far beyond simple financial planning. They consider the inherited ideas of responsibility and success that shape our choices—and what becomes possible when we ask not only what is practical, but what we genuinely want.The conversation also connects with the upcoming launch of The Fires We Lit: Illustrated Stories of Women Reimagining the Rules, where Sharma Wealth is one of the sponsors. Like the stories in the anthology, Shivika invites listeners to question prescribed paths, reclaim the ability to dream, and imagine a future that feels like their own.Resources mentioned:Sharma Wealth, Richardson WealthThe Fires We Lit LaunchCampfire Kinshipwww.campfirekinship.com

In this episode of That's So Hindu, Mat McDermott speaks with Ranjna Sharma, whose family members in Ireland assisted victims' families in the aftermath of the bombing of Air India flight 182, in 1985. She shares her family's connection to the aftermath in Ireland, reflections on the impact of terrorism, and insights on the ongoing repercussions within diaspora communities. This conversation highlights the importance of remembrance, reconciliation, and understanding the roots of violence in the Khalistan movement. Hosted on Acast. See acast.com/privacy for more information.

In this episode of That's So Hindu, Mat McDermott speaks with Ranjna Sharma, whose family members in Ireland assisted victims' families in the aftermath of the bombing of Air India flight 182, in 1985. She shares her family's connection to the aftermath in Ireland, reflections on the impact of terrorism, and insights on the ongoing repercussions within diaspora communities. This conversation highlights the importance of remembrance, reconciliation, and understanding the roots of violence in the Khalistan movement. Hosted on Acast. See acast.com/privacy for more information.

Whoa, Shuhei!  We’ve got a lot to talk about.  Stack it up and feel the power of a superior sextet!  Join Tricky, Matt, Alex, Yield, Darrell and Joe as they discuss, among other things, Buckshot Roulette, Dinoblade, Mercenaries 2: World in Flames, and Palworld.  What’s more, we delve into the most recent PlayStation Network outage, and we ponder Xbox CEO Asha Sharma’s admission that Game Pass has not “provided meaningful growth” (for Microsoft).  After what seemed like a rather rosy start for Sharma, she seems to be cleaning up quite the mess.  Who wants all that stress?  Former Xbox executives Phil Spencer and Sarah Bond absorbed game companies like Pac-Man — or Ms. Pac-Man — devoured pellets and adopted a multiplatform publishing strategy.  Sharma cited multiplatform sales as failing to meet internal expectations.  With rumors swirling that Microsoft wants to spin off its Xbox gaming division, we wonder how Sharma can turn this around the Xbox brand. And if you think that’s all, then you’ve got another thing coming!  As usual, the news is full of surprises.  We hit the high notes, and we hit the low notes, but we’ll always bring the banter.  What are you waiting for? Dive in! As always, the opinions fly fast and heavy! Look out for this super-sized show, as the seemingly smallest conversation veers off into a multiverse of chit-chat. Sounds cool, huh? That’s the fancy way of saying “derailment.” And there’s plenty of that to go around! Let’s dance, Heroes of the XMB! In a bit of big news that would make the Teenage Mutant Ninja Turtles proud, iHeartRadio, Pandora and Spotify host episodes of Trophy Whores. It's a tremendous honor for the show to be part of three massive and respected entertainment communities, and Proven Gamer have only the fans to thank for pushing the podcast to soaring heights. The Trophy Whores work hard to put out a quality weekly show, but they owe so much love to their listeners, who keep the show strong and growing. If you want to support the show via Patreon, then check out our page, which shares the tiers for all of our Patrons! We appreciate your support (and your ears)! Please subscribe to the Trophy Whores feed in iTunes, Google Play, TuneIn, IHeartRadio, Stitcher, or RSS and please leave a review. We won't give you cookies, but it will help us make the show better. You can find us on Twitter: @TrophyWhores and @ProvenGamer You can also email us at TrophyWhores. If you wish, you can always download the show here – Trophy Whores 725 – Six-Way Melee

This week, host Daniel Raimi brings Ishan Sharma on the podcast to discuss the beginnings of the geologic hydrogen industry. Sharma, director and founder of a fund at Renaissance Philanthropy that seeks to grow hydrogen into a competitive energy provider, draws upon the trajectories of sectors such as oil and gas—and newer additions, like geothermal energy—to argue that with enough investment, the abundant hydrogen gas trapped beneath the Earth's surface could be a major player in the energy game. As hydrogen is a natural output of common chemical reactions, such as the interaction of iron and water, there's no shortage of the resource; the issue is how to find it. While interest in geologic hydrogen is ramping up, the industry faces feasibility issues related to incomplete public information, lack of understanding about the subsurface world, and regulatory voids—however, Sharma believes this low-carbon source has a bright future. References and recommendations: Chimaera Fund; https://www.renaissancephilanthropy.org/chimaera-fund “Designing a Life That Matters” episode of the “Hidden Brain” podcast; https://www.hiddenbrain.org/podcast/designing-a-life-that-matters/ “Odd Lots” podcast from Bloomberg; https://www.bloomberg.com/oddlots “Ministry for the Future” book; https://www.hachettebookgroup.com/titles/kim-stanley-robinson/the-ministry-for-the-future/9780316300162/ Subscribe to stay up to date on podcast episodes, news, and research from Resources for the Future: https://www.rff.org/subscribe/

Send us Fan MailAnne Huntington Sharma explains how leaders can honor a company's history while still making the difficult decisions required for its next chapter. Drawing from her path from “center number 17” to President and CEO of Huntington Learning Center, she explores succession, franchise growth, digital transformation, and the discipline of evolving only when change creates measurable value.Show NotesThe Strategic FocusThis conversation examines what it takes to lead a second generation company with credibility, patience, and strategic clarity, especially when the business must preserve a proven model while adapting to new technology, changing customer expectations, and a complex franchise network.Key TakeawaysLegacy leadership requires more than inheritance; it demands outside experience, operational credibility, and the humility to build a team with deeper expertise than your own.Successful transformation begins with a real market need, followed by careful testing, franchisee input, and consistent communication before broad implementation.Succession is not a single event but a long process built on trust, role clarity, honest dialogue, and a shared understanding of what the business will need next.Franchising can create scalable impact and recurring revenue, but only when the model is repeatable, the founder can relinquish control, and franchisees have meaningful forums for feedback.Guest Contact & ConnectAnne Huntington Sharma is President, CEO, and Board Member of Huntington Learning Center, where she leads strategy, partnerships, innovation, and the continued evolution of a nearly 50 year education brand.Website: https://huntingtonhelps.com/LinkedIn: https://www.linkedin.com/in/anne-huntington-sharma/Instagram: https://www.instagram.com/huntingtonhelps/Facebook: https://www.facebook.com/HuntingtonHelpsJoin the proveHER community and explore the companion blogcast for deeper insights, practical tools, and continued conversations with women building influential, enduring businesses.---Subscribe and ReviewIf you loved this episode, drop us a review, share it with a badass woman in your life, and subscribe to Badass Women in Business wherever you get your podcasts.Stay badass. Stay bold. Build it your way.Keep up with more content from Aggie and Cristy here:Facebook: Empowered Women Leaders  Instagram: @badass_women_in_businessLinkedIn: ProveHer - Badass Women in BusinessWebsite: Badasswomeninbusinesspodcast.comAthena: athenaac.com

Venkee Sharma is the Executive Chairman of Aquatech, a global leader in water and critical metals technology.Topics:Aquatech's “superpower”Seizing opportunities in lithiumThe TeamAquatech's view of the marketDLEThe op-ex challengeBelievers in brineThe future of battery gradeFans of the SmackoverDifferent customers – different problemsSelling solutions not technologyA family cultureThe White Silver ProjectPearlRapid fire

07-25-26 Girl Talk with Dr. Vedica Sharma, and Proto Hologram by

TIME STAMP INFO:00:00:35 Intros00:07:00 Introducing XBOX Backward Compatibility on PC. XBOX Continues To Deliver On Their Promise On Game Preservation. 00:47:00 Project Helix's New Direction Has EVERYONE Talking | How Will Asha Sharma "Rethink" Its Development? 01:29:00 Outros

Ep. 215 - Kimberly sits down with author, speaker, and mind-set coach Jaikishaan Sharma. After losing his job, buying a home, and welcoming a newborn daughter, Jackishan suffered a life-altering accident when he was hit by a speeding car as a pedestrian. Doctors gave him just a 5% chance of ever walking again. Paralyzed from the waist down, Jackishan plunged into financial hardship, severe depression, and suicidal ideation. However, a single transformative moment with his young daughter sparked a inner shift. Through intense mindset work, journaling, formal and informal mindfulness, water therapy, and sheer determination, Jackishan went from paralyzed in a wheelchair to standing back up on his feet. Today, he shares his roadmap to help others break through physical and emotional trauma. Chapter Timestamps: 1:48 – The Perfect Storm (Job Loss, New Baby & Mortgage) 5:19 – The Accident & Diagnosis 7:13 – Inpatient Rehab, Financial Stress & Depression 12:00 – Forgiving the Driver & Finding Healing 17:41 – The Turning Point & Mindset Work 25:15 – Journaling, Mindset Shifts & Keeping the Wheelchair 28:10 – The First Sign of Recovery (The Moving Toe) 29:54 – Priming, Mindfulness & Visualizations 33:58 – Standing Up & Surprising the Doctor 38:31 – The Emotional Breakdown & Gratitude for Family 42:18 – Walking Again & Transitioning Off the Wheelchair 43:40 – Finding Purpose & Helping Others Online 47:44 – Trauma Coaching & From Wheelchair to Dream Chair 51:24 – Redefining Success & Final Words of Wisdom 53:12 – Outro & Where to Connect Follow Jaikishaan Sharma: https://www.instagram.com/jaikishaansharma/ Follow Kimberly: https://www.instagram.com/kimberlylovi/

Support ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Boss Rush on Patreon⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.Xbox's reset era continues as CEO Asha Sharma makes difficult but necessary changes to the company's studio lineup, leadership, and franchise strategy, reshaping the brand around its biggest strengths.On this episode of the Boss Rush Podcast, Corey Dirrig discusses what Sharma's studio-management overhaul could mean for the teams behind Fallout, Halo, and more. He also examines PlayStation's evolving approach to physical media and live-service games, the changing stewardship of major franchises, and the tension between creative ambition and financial reality. This and more on the Boss Rush Podcast, part of ⁠the Boss Rush Network⁠.Email us your ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠questions and topic ideas to the podcast here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.Join the ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Boss Rush Network Community Discord⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.Follow the Boss Rush Network on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠X/Twitter⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Bluesky⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠LinkedIn⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Threads⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, and ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.Thanks for your continued support of the Boss Rush Podcast and the Boss Rush Network! If you listen on podcast services, leave us a 5 star rating and a nice review or comment. If you're listening to this episode on YouTube, subscribe to the channel, like the video, leave a comment, and hit the bell so you don't miss an episode posting. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Visit our website for more great content⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ from Boss Rush and our community.

ThePrintPod: Ankit Sharma: Boy with fauji dreams grew up in alleys of North East Delhi, killed before big IB promotion

CarneyShow 07.16.26 Dr Vedica Sharma, Nihaar Sinha, Brendan Wiese, Alex Stone by

Whoa, Shuhei!  We’ve got a lot to talk about.  Stack it up and feel the power of a tremendous trio!  Join Tricky, Alex and Yield as they discuss, among other things, Hellblade: Senua’s Sacrifice, Furi, and Assassin’s Creed Black Flag Resynced.  What’s more, we lament significant layoffs within XBOX Game Studios as part of a “reset” of the division, and we delve into Sony’s continued silence against fallout for aggressively pushing an all-digital future.  As we have continually said, Sony need to clarify if the discontinuation of discs covers all games published for PlayStation consoles.  As you might imagine, Sony’s announcement has caused a firestorm of chatter on the Internet.  And Sony are certainly taking their lumps.  Despite a wide proliferation of digital sales, we all know people who have sworn allegiance to physical media — and they will die on that hill. And if you think that’s all, then you’ve got another thing coming!  As usual, the news is full of surprises.  We hit the high notes, and we hit the low notes, but we’ll always bring the banter.  What are you waiting for? Dive in! As always, the opinions fly fast and heavy! Look out for this super-sized show, as the seemingly smallest conversation veers off into a multiverse of chit-chat. Sounds cool, huh? That’s the fancy way of saying “derailment.” And there’s plenty of that to go around! Let’s dance, Heroes of the XMB! In a bit of big news that would make the Teenage Mutant Ninja Turtles proud, iHeartRadio, Pandora and Spotify host episodes of Trophy Whores. It's a tremendous honor for the show to be part of three massive and respected entertainment communities, and Proven Gamer have only the fans to thank for pushing the podcast to soaring heights. The Trophy Whores work hard to put out a quality weekly show, but they owe so much love to their listeners, who keep the show strong and growing. If you want to support the show via Patreon, then check out our page, which shares the tiers for all of our Patrons! We appreciate your support (and your ears)! Please subscribe to the Trophy Whores feed in iTunes, Google Play, TuneIn, IHeartRadio, Stitcher, or RSS and please leave a review. We won't give you cookies, but it will help us make the show better. You can find us on Twitter: @TrophyWhores and @ProvenGamer You can also email us at TrophyWhores. If you wish, you can always download the show here – Trophy Whores 723 – Sharma Resets XBOX

Sanjeev Sharma explains his S&P 500 prediction for 2026 (0:35) LLMs, AI effects, and semis (10:40)Show Notes:S&P 500 Will Be Around 6,300 By The End Of 2026S&P 500: 7,000 Target For 2025 - Sanjeev SharmaEpisode transcriptsFor full access to analyst ratings, stock quant scores and dividend grades, subscribe to Seeking Alpha Premium at seekingalpha.com/subscriptions

ThePrintAM: Ankit Sharma murder case: Why did Delhi court convict Tahir Hussain?

Prachi Sharma shares how her mother's cooking influenced her to save the recipes.

IN CLEAR FOCUS: Guest Anne Huntington Sharma, CEO of Huntington Learning Center, explores brand stewardship in an age of AI-led disruption. Discover how a nearly 50-year-old heritage brand is reinventing its identity to connect with millennial parents while preserving accumulated trust. Learn about balancing franchise collaboration with compliance, integrating artificial intelligence tools like agentic tutors, and leveraging both physical and digital experiences to drive results.

Tonight's questions: Will the PS6's price affect hardware sales? What advancements could next-gen consoles introduce? Should Xbox Game Pass change its pricing? Are gaming protests effective? How long will Nintendo manufacture Switch 1 for? Which studio should spin off from Sony? What is the meaning of Sharma's role in the Fed? What is your favorite Ace Combat 8? Which game has excessive lore? What hobby could replace gaming for you? Thanks as always to Shawn Daley for our intro and outro music. Follow him on Soundcloud: https://soundcloud.com/shawndaleyWhere to find Throwdown Show:Website: https://audioboom.com/channels/5030659Twitch: https://www.twitch.tv/throwdownshowX: https://x.com/ThrowdownShowYouTube: https://www.youtube.com/throwdownshowDiscord: https://discord.gg/fdBXWHTTwitter list: https://twitter.com/i/lists/1027719155800317953

Dr. Vishal Sharma, VP of Clinical Education & Operations at Spear Education shares his thoughts on: DSOs failing at clinical education Education as a performance & retention lever $3,500 per day associate production To learn more about Spear Education visit: https://www.speareducation.com/ You can also contact Dr. Sharma via email: vsharma@speareducation.com or on LinkedIn: https://www.linkedin.com/in/dr-vishal-sharma-78527543/  

Xbox just got torched, and the math says new games can't win.Jen and Eric (two for TWIG this week) break down the biggest restructuring in Xbox history: 4,800 jobs cut, Asha Sharma unwinding Phil Spencer's entire studio buying spree, and King and Minecraft pulled in to report directly to her. Is this the setup for an Activision Blizzard 2.0 spin-out? Then they dig into fresh Newzoo data on why only 6% of the market is open to new IP, why forever games keep winning, and how growth has become an ARPU story instead of a new-player story.Topics Covered:• Microsoft cuts 4,800 jobs and 20% of Xbox's workforce• Sharma's memo and the "apex predator" restructuring playbook• King and Minecraft reporting straight to Sharma• Compulsion and Double Fine go independent with their IP• Helen Chang named Xbox's first COO, and what a single P&L signals• The spin-out theory and Activision Blizzard 2.0• Game Pass is stuck at 30 million and devaluing the $80 game• Why only 6% of the market is open to new IP• 60% of revenue coming from games five years or older• Growth as an ARPU story in the West and China• Last War, Whiteout Survival and Kingshot are proving the UA arbitrage gameCHAPTERS:00:00 - Werlcome & Agenda01:57 - World Cup Keeper Highlights03:35 - Kress's New Setup & Family Updates05:42 - NYT Games Shill07:30 - Xbox Rumors to Reality10:51 - Layoffs & Studio Shuffles13:26 - GamePass Stalls at 30 Mil14:45 - King, Mobile, and Minecraft Blindspots19:40 - Vanity Metrics Reality Check21:52 - COO PnL and Platform Model Critique24:22 - Booty Portfolio Shrinks & Next Steps25:46 - Gamepass Devalues Games27:01 - Publishers abandon Xbox28:25 - Spinout and Activision 2.030:04 - Microsoft & King Strategy32:29 - Embracer Parallel Lessons36:14 - Easy Cuts & Creative's Hard Work46:28 - Pipeline Worries for New Hits50:27 - ARPU & GTA Monetization53:11 - Mobile UA Arbitrage Reality54:58 - What Could Save the Industry

With the plurality of Hinduism in mind, The Bloomsbury Handbook of Hindu Ethics focuses on the human, sociological and situational ethical framework underpinning Hindu ethics. Chapters go beyond the traditional classical sources-such as the Vedas, epics, mythological narratives and Dharmasastra texts-to include lesser known vernacular based moral texts, as well as contemporary sources from organizations, intellectuals and movements of religious, social and political nature.Going beyond only theological and philosophical discussions, this handbook presents a truly multidisciplinary approach to Hindu ethics. This book will benefit not only scholars and students within religious studies and philosophy, but also those from sociology, history, theology, law, anthropology and literature. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

With the plurality of Hinduism in mind, The Bloomsbury Handbook of Hindu Ethics focuses on the human, sociological and situational ethical framework underpinning Hindu ethics. Chapters go beyond the traditional classical sources-such as the Vedas, epics, mythological narratives and Dharmasastra texts-to include lesser known vernacular based moral texts, as well as contemporary sources from organizations, intellectuals and movements of religious, social and political nature.Going beyond only theological and philosophical discussions, this handbook presents a truly multidisciplinary approach to Hindu ethics. This book will benefit not only scholars and students within religious studies and philosophy, but also those from sociology, history, theology, law, anthropology and literature. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/south-asian-studies

TIME STAMPS:00:00:01 Community Guest Intros00:00:35 Asha Sharma On Resetting XBOX For A Stronger Future | This Changes Everything!00:55:00 Playstation's Move Away From ALL Physical Media Is More Concerning Then Gamers Realize. A FULL Breakdown On Why It Will Be VERY Bad For Consumers and Retailers!01:57:00 Panel Outros and Special Message to the Community!

TIME STAMP INFO:00:00:01 Intros00:00:35 XBOX's Asha Sharma Announces BIG Changes For XBOX Game Studios | NO Studios Are Being Closed!0045:00 Bethesda will be overhauled, as part of today's Xbox changes, to focus on key franchises going forward: Fallout, The Elder Scrolls, Doom, Quake and Wolfenstein01:37:00

TIME STAMP INFO:00:00:01 Intros00:00:35 BREAKING NEWS: XBOX CEO, Asha Sharma Has Announced What s Happening With The BIG XBOX Reset!01:11:00 Outros Video

Dr. Niraj Sharma of Cardinal Spine and Pain Medicine joins us to discuss non-surgical treatment options for low back pain, neck pain, herniated discs, spinal stenosis, pinched nerves, and other problems. Ray Graf hosts.

Growing up, we didn't see enough people who looked like us on screen and the representation we did get was often stereotypical and wasn't one we recognised ourselves in which is why this episode means a lot to me as I sit down with the cast and director of a new British South Asian film called Never Had a Chance. Never Had A Chance is an award-winning British Asian film set in the heart of the Punjabi community in Hounslow, West London. It is directed by Jazz Bhalla and stars Tina Sharma and Amar Chaggar. The film follows Ravi (Amar Chaggar), a young man navigating the weight of his past while trying to build a future. When a new connection offers a glimpse of something more stable and meaningful, he finds himself at a crossroads but those closest to him threaten to pull him back into the life he's trying to leave behind.In this episode we talk about:

In this episode, Mimi Banks of MB Social is joined by Aditi Sharma. Aditi shares her inspiring journey from growing up in her mother's salon to founding QOAT Hair, a professional hair care brand. She discusses lessons learned from her career at L'Oreal, the importance of community in entrepreneurship, and the future of professional beauty. Follow QOAT on Instagram @qoathair TikTok @qoathairInstagram: https://www.instagram.com/beautybizshow/See omnystudio.com/listener for privacy information.

Host Gautam Bhattacharyya welcomes barrister Chinmayi Sharma of Three Verulam Buildings for this episode of Spotlight on… Chinmayi reflects on her path into the legal profession, the mentors and career highlights that have shaped her journey, and what South Asian heritage means to her personally. The conversation also explores the evolution of India's legal market and its potential as an arbitration hub.

The AI boom is tossing equities around like tiny boats. Today on the show, Katie Martin and Rob Armstrong ask investor Ruchir Sharma how to ride it all out. Sharma is the chair of Rockefeller International and the author of What Went Wrong with Capitalism. The show was recorded at the FT Weekend Festival in New York. Also they go long quality stocks that are out of the tech spotlight and short sharks. For a free 30-day trial to the Unhedged newsletter go to: https://www.ft.com/unhedgedoffer.You can email Robert Armstrong and Katie Martin at unhedged@ft.com.Read a transcript of this episode on FT.com Hosted on Acast. See acast.com/privacy for more information.

Sometimes V-fib doesn't respond to the shock at all. Sometimes it converts and comes right back. Those are two completely different problems.In this episode, Sarah breaks down the science behind why defibrillation fails, how to recognize the difference between refractory and recurrent V-fib, and respond when shocks aren't working. You'll learn how to start approaching the electrical storm at the bedside — that means understanding transthoracic impedance, optimizing your pad placement, and knowing when to reach for double sequential defibrillation.Topics discussed in this episode:Refractory vs. recurrent V-fibThe physiology of ventricular fibrillation and re-entry tachycardiasMisconceptions about defibrillationTransthoracic impedance and how to reduce itAnterior-lateral vs. anterior-posterior pad placementDouble sequential defibrillation: evidence and objectionsKey findings from the DOSE VF trialAmerican Heart Association. (2025). 2025 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation.Cheskes, S., Dorian, P., Feldman, M., McLeod, S., Scales, D. C., Pinto, R., Turner, L., Morrison, L. J., Drennan, I. R., & Verbeek, P. R. (2020). Double sequential external defibrillation for refractory ventricular fibrillation: The DOSE VF pilot randomized controlled trial. Resuscitation, 150, 178–184. https://doi.org/10.1016/j.resuscitation.2020.02.010D. Hasegawa, A. Sharma, Y. I. Lee, & R. Sato. (2023). A systematic review and meta-analysis of esmolol for refractory ventricular fibrillation and pulseless ventricular tachycardia. Chest, 164(4 Suppl.), A1568. https://doi.org/10.1016/j.chest.2023.07.1077International Liaison Committee on Resuscitation. (2025). 2025 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations (CoSTR).Mentioned in this episode:CONNECT

In this episode of the Optimal Body Podcast, Doc Jen and Doctor Dom welcome running expert Doctor of physical therapy Vikash Sharma to discuss how to run safely and effectively. They cover key topics like avoiding the "too much, too quickly" trap, using walk-run intervals for beginners, and following the 10% rule for mileage progression. Dr. Sharma also shares valuable advice on strength training exercise (especially calf and hip work), managing common running injuries and pain, and choosing the right footwear. Plus, there's helpful guidance for women returning to running postpartum. A must-listen for anyone looking to run smarter! Zulu Weighted Vest: Upgrade your everyday movement with the ZULU Weighted Vest — designed to increase calorie burn, naturally engage your core, and improve posture with every step. Perfect for walks, workouts, and daily errands. Use code OPTIMAL for 20% off at checkout. Needed Discount: Jen trusted Needed Supplements for fertility, pregnancy, and beyond! Support men and women's health with vitamins, Omega-3, and more. Used by 6,000+ pros. Use code OPTIMAL for 20% off at checkout! Dr Sharma's Resources: Perfect Stride Website Dr Sharma on IG Perfect Stride on IG Perfect Stride on YT Perfect Stride on FB We Think You'll Love: Free Week of Jen Health Jen's Instagram Dom's Instagram YouTube Channel For full show notes and resources visit https://jen.health/podcast/465 What You'll Learn: 4:13 Dr. Sharma shares his personal history with running, which started in middle school and became a lifelong passion. 8:19 Dr. Sharma explains that the most common reason for running injuries is doing "too much, too quickly" without proper adaptation. 10:08 Recommendations for beginners include... Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Is it off-screen chemistry, or is it just good marketing? Hosts Sanjana Basker and Tyler McCall open with the Brett Goldstein and JLo Office Romance press tour—and what it means when a man manifests his lifelong crush into a co-starring role. Then scholar and author Nisha Sharma joins to talk about her research on dark romance and reproductive coercion, including how the genre’s relationship to consent has shifted alongside the political landscape, and whether dark romance could do better without losing what makes it so compelling. Plus: a listener voicemail sends Sanj and Tyler deep into Off Campus territory. Office Romance starring JLo and Brett Goldstein is streaming now on Netflix—clearly we’ll be discussing. Nisha Sharma, author of The Letters We Keep, is studying the intersection of law, politics, and culture in romance fiction. Her Substack post on dark romance and reproductive coercion tees up this episode’s conversation. A few dark romances for discussion: Lights Out by Navessa Allen, Brynn Weaver and Allie Oleander’s work, and Nobody’s Baby But Mine by Susan Elizabeth Phillips. It’s time for the Off Campus discourse! The correct answer to listener Lacey's question is Dean Di Laurentis. See omnystudio.com/listener for privacy information.