Podcasts about pathogenic microbes

In this episode, we explore the role of probiotics in managing histamine levels and mast cell activation syndrome (MCAS), particularly in the context of rebuilding the gut microbiome. We discuss which probiotic strains could contribute to symptoms (in the short term) due to their histamine-producing properties, such as Lactobacillus casei and Lactobacillus reuteri, and we highlight beneficial strains that degrade histamine, including Lactobacillus plantarum. Topics: 1. Introduction to Histamine and Mast Cell Activation - Overview of histamine and mast cell activation syndrome (MCAS) - Understanding histamine production 2. Breakdown of White Blood Cells (WBCs) - Origin of WBCs from hematopoietic stem cells in the bone marrow - Categories of WBCs: granulocytes, monocytes, and lymphocytes 3. Examination of Granulocytes - Neutrophils: Role in bacterial infections - Eosinophils: Role in allergic reactions and parasitic infections - Basophils: Involvement in inflammatory and allergic responses through histamine release - Mast Cells: Similarities to basophils, maturation in tissues, and histamine release 4. Examination of Agranulocytes - Monocytes: Phagocytic function and differentiation into macrophages and dendritic cells - Lymphocytes: - T cells: Subtypes and their functions (helper T cells, cytotoxic T cells, regulatory T cells) - B cells: Antibody-mediated immunity - NK cells 5. Mast Cells vs. Basophils - Location and function comparison - Importance in histamine production 6. Mast Cell Activation Syndrome (MCAS) - Triggers of MCAS (infections, environmental exposures, dietary factors, genetic predispositions) - Focus on addressing root causes (lyme?, mold?, candida?, SIBO?, ...) 7. Probiotic Use in the Context of MCAS - Probiotics and pathogenic microbes in the context of mast cell activation 8. Example: Candida and Mast Cell Interaction - Recognition of Candida by mast cells through pattern recognition receptors (PRRs) - Activation pathways and release of histamine and other inflammatory mediators 9. Probiotics and Histamine Production - Probiotic strains that produce histamine - Lactobacillus casei, - Lactobacillus reuteri, - Lactobacillus bulgaricus... - Probiotic strains that do not produce histamine and/or degrade histamine - Bifidobacterium infantis, - Bifidobacterium longum, - Bifidobacterium bifidum, - Bifidobacterium breve, - Lactobacillus plantarum, - Lactobacillus rhamnosus, - Lactobacillus gasseri, - Lactobacillus salivarius Thank you to our episode sponsors: ⁠⁠⁠Liver Medic⁠⁠⁠⁠ Use code Chloe20 to save 20% on ⁠⁠⁠⁠⁠"Leaky Gut Repair"⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠Brendan's YouTube Channel⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠https://x.com/livermedic⁠⁠⁠⁠⁠ Tremetes, LLC Use code CHLOE15 to get 15% off Tremetes' Turkey Tail Thanks for tuning in! Get Chloe's Book Today! "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠75 Gut-Healing Strategies & Biohacks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠" Follow Chloe on Instagram ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@synthesisofwellness⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Follow Chloe on TikTok @chloe_c_porter Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠synthesisofwellness.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to purchase products, subscribe to our mailing list, and more! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.29.221010v1?rss=1 Authors: Yao, G., Zhang, W., Yang, M., Yang, H., Wang, J., Zhang, H., Wei, L., Xie, Z., Li, W. Abstract: Microbes play important roles in human health and disease. The interaction between microbes and hosts is a reciprocal relationship, which remains largely under-explored. Current computational resources lack manually and consistently curated data to connect metagenomic data to pathogenic microbes, microbial core genes, and disease phenotypes. We developed the MicroPhenoDB database by manually curating and consistently integrating microbe-disease association data. MicroPhenoDB provides 5677 non-redundant associations between 1781 microbes and 542 human disease phenotypes across more than 22 human body sites. MicroPhenoDB also provides 696,934 relationships between 27,277 unique clade-specific core genes and 685 microbes. Disease phenotypes are classified and described using the Experimental Factor Ontology (EFO). A refined score model was developed to prioritize the associations based on evidential metrics. The sequence search option in MicroPhenoDB enables rapid identification of existing pathogenic microbes in samples without running the usual metagenomic data processing and assembly. MicroPhenoDB offers data browsing, searching and visualization through user-friendly web interfaces and web service application programming interfaces. MicroPhenoDB is the first database platform to detail the relationships between pathogenic microbes, core genes, and disease phenotypes. It will accelerate metagenomic data analysis and assist studies in decoding microbes related to human diseases. MicroPhenoDB is available through http://www.liwzlab.cn/microphenodb and http://lilab2.sysu.edu.cn/microphenodb. Copy rights belong to original authors. Visit the link for more info

Paul Jackson, Division Leader of the Biosciences and Biotechnology Division at Lawrence Livermore National Lab, presents a brief history of antibiotic use and discusses the medical and public policy factors that are, in part, responsible for increased antibiotic resistance in pathogenic microbes. He and biology teacher Frankie Tate then introduce a new generation of antimicrobial compounds that are derived from the bacteria's own genes that may be clinically useful to treat infections caused by antibiotic resistant pathogens. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 24518]

Paul Jackson, Division Leader of the Biosciences and Biotechnology Division at Lawrence Livermore National Lab, presents a brief history of antibiotic use and discusses the medical and public policy factors that are, in part, responsible for increased antibiotic resistance in pathogenic microbes. He and biology teacher Frankie Tate then introduce a new generation of antimicrobial compounds that are derived from the bacteria's own genes that may be clinically useful to treat infections caused by antibiotic resistant pathogens. Series: "Lawrence Livermore National Lab Science on Saturday" [Science] [Show ID: 24518]