Podcasts about mcas

Listen and subscribe to Money Making Conversations on iHeartRadio, Apple Podcasts, Spotify, www.moneymakingconversations.com/subscribe/ or wherever you listen to podcasts. New Money Making Conversations episodes drop daily. I want to alert you, so you don’t miss out on expert analysis and insider perspectives from my guests who provide tips that can help you uplift the community, improve your financial planning, motivation, or advice on how to be a successful entrepreneur. Keep winning! Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Sahra S. Halpern. Interview Purpose The purpose of this interview is to educate small business owners—especially entrepreneurs of color—about equitable access to capital, alternative lending pathways, and how to become “capital ready.” Sahra Halpern, President and CEO of the Business Consortium Fund (BCF), explains how mission‑driven lending fills the gap left by traditional banks and helps small businesses survive, grow, and ultimately graduate into mainstream financing. The conversation also aims to demystify lending, reduce fear around capital, and encourage entrepreneurs to build trusted financial relationships before entering moments of crisis. Core Themes Discussed 1. Why Small Businesses Are Turned Down by Banks Halpern explains that many small businesses are rejected by banks not because they lack potential, but because banks operate under strict underwriting and regulatory requirements. These systems often fail to account for resilience, experience, contracts, and future growth. BCF exists to serve as a bridge—supporting businesses where banks cannot and preparing them to eventually return as qualified borrowers. 2. Capital Curious vs. Capital Ready A key distinction introduced in the interview is the difference between businesses that are “capital curious” and those that are “capital ready.” Many entrepreneurs know they need funding but lack: Financial organization Clear projections Proper documentation A capital strategy BCF provides technical assistance to help businesses prepare for financing instead of setting them up to fail. 3. Mission‑Driven Lending and Community Impact Halpern frames lending as an ecosystem, not a transaction. When small businesses succeed: Business owners gain stability Employees gain jobs Communities grow stronger Large corporations benefit from more diverse and capable supply chains BCF focuses on long‑term economic impact, not short‑term profit. 4. CDFIs vs. SBA Loans The interview draws a clear distinction between Community Development Financial Institutions (CDFIs) like BCF and government entities such as the SBA. Key differences highlighted: SBA programs shift based on political administrations SBA underwriting has tightened in recent years CDFIs are nonprofit, mission‑aligned, and relationship‑driven CDFIs look at the whole entrepreneur, not just credit scores 5. The Danger of Merchant Cash Advance Loans Halpern strongly warns against Merchant Cash Advance (MCA) loans, which are often marketed as fast solutions but carry extremely high interest rates and long‑term consequences. She explains that: MCAs disqualify borrowers from future SBA refinancing They often trap business owners in cycles of expensive debt CDFIs like BCF can help refinance and escape these loans A real‑world case study (The Cut Buddy / Shark Tank entrepreneur) illustrates how BCF helped refinance over $1M in predatory debt and save a growing business. 6. Relationships Matter More Than Transactions Both Halpern and McDonald emphasize the importance of building lender relationships early, not only when cash flow is tight. BCF underwrites the entire business and the entrepreneur, rather than seizing control of a contract or revenue stream, as some factoring companies do. Power comes from having options—and informed decision‑making. Key Takeaways Banking rejection is not the end of the road Small businesses must prepare themselves to be capital ready CDFIs serve as critical bridges between entrepreneurs and traditional banks Fast money often leads to expensive, dangerous debt Merchant cash advances should be avoided whenever possible Mission‑driven lenders look at the whole entrepreneur, not just numbers Strong lender relationships protect businesses during uncertainty Capital should empower growth—not take control of your company Notable Quotes “Just because a bank says no doesn’t mean that’s the end of your road.” “We’re not just looking at your credit score—we’re looking at you as a whole entrepreneur.” “Capital readiness is not about desperation; it’s about preparation.” “If you’re sitting on a merchant cash advance loan right now, you are not stuck.” “Nothing makes me happier than seeing clients realize their dreams and grow into multimillion‑dollar businesses.” “You should talk to multiple lenders—but you should always understand the real cost of the money.” Conclusion Sahra Halpern’s interview serves as a practical roadmap and a cautionary lesson for small business owners navigating today’s uncertain economic landscape. It reinforces that access to capital is about strategy, education, and relationships, not just approval or rejection. The conversation encourages entrepreneurs to reclaim power, avoid predatory financing, and partner with institutions that are committed to their long‑term success and community impact. #SHMS #BEST #STRAWSupport the show: https://www.steveharveyfm.com/See omnystudio.com/listener for privacy information.

Listen and subscribe to Money Making Conversations on iHeartRadio, Apple Podcasts, Spotify, www.moneymakingconversations.com/subscribe/ or wherever you listen to podcasts. New Money Making Conversations episodes drop daily. I want to alert you, so you don’t miss out on expert analysis and insider perspectives from my guests who provide tips that can help you uplift the community, improve your financial planning, motivation, or advice on how to be a successful entrepreneur. Keep winning! Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Sahra S. Halpern. Interview Purpose The purpose of this interview is to educate small business owners—especially entrepreneurs of color—about equitable access to capital, alternative lending pathways, and how to become “capital ready.” Sahra Halpern, President and CEO of the Business Consortium Fund (BCF), explains how mission‑driven lending fills the gap left by traditional banks and helps small businesses survive, grow, and ultimately graduate into mainstream financing. The conversation also aims to demystify lending, reduce fear around capital, and encourage entrepreneurs to build trusted financial relationships before entering moments of crisis. Core Themes Discussed 1. Why Small Businesses Are Turned Down by Banks Halpern explains that many small businesses are rejected by banks not because they lack potential, but because banks operate under strict underwriting and regulatory requirements. These systems often fail to account for resilience, experience, contracts, and future growth. BCF exists to serve as a bridge—supporting businesses where banks cannot and preparing them to eventually return as qualified borrowers. 2. Capital Curious vs. Capital Ready A key distinction introduced in the interview is the difference between businesses that are “capital curious” and those that are “capital ready.” Many entrepreneurs know they need funding but lack: Financial organization Clear projections Proper documentation A capital strategy BCF provides technical assistance to help businesses prepare for financing instead of setting them up to fail. 3. Mission‑Driven Lending and Community Impact Halpern frames lending as an ecosystem, not a transaction. When small businesses succeed: Business owners gain stability Employees gain jobs Communities grow stronger Large corporations benefit from more diverse and capable supply chains BCF focuses on long‑term economic impact, not short‑term profit. 4. CDFIs vs. SBA Loans The interview draws a clear distinction between Community Development Financial Institutions (CDFIs) like BCF and government entities such as the SBA. Key differences highlighted: SBA programs shift based on political administrations SBA underwriting has tightened in recent years CDFIs are nonprofit, mission‑aligned, and relationship‑driven CDFIs look at the whole entrepreneur, not just credit scores 5. The Danger of Merchant Cash Advance Loans Halpern strongly warns against Merchant Cash Advance (MCA) loans, which are often marketed as fast solutions but carry extremely high interest rates and long‑term consequences. She explains that: MCAs disqualify borrowers from future SBA refinancing They often trap business owners in cycles of expensive debt CDFIs like BCF can help refinance and escape these loans A real‑world case study (The Cut Buddy / Shark Tank entrepreneur) illustrates how BCF helped refinance over $1M in predatory debt and save a growing business. 6. Relationships Matter More Than Transactions Both Halpern and McDonald emphasize the importance of building lender relationships early, not only when cash flow is tight. BCF underwrites the entire business and the entrepreneur, rather than seizing control of a contract or revenue stream, as some factoring companies do. Power comes from having options—and informed decision‑making. Key Takeaways Banking rejection is not the end of the road Small businesses must prepare themselves to be capital ready CDFIs serve as critical bridges between entrepreneurs and traditional banks Fast money often leads to expensive, dangerous debt Merchant cash advances should be avoided whenever possible Mission‑driven lenders look at the whole entrepreneur, not just numbers Strong lender relationships protect businesses during uncertainty Capital should empower growth—not take control of your company Notable Quotes “Just because a bank says no doesn’t mean that’s the end of your road.” “We’re not just looking at your credit score—we’re looking at you as a whole entrepreneur.” “Capital readiness is not about desperation; it’s about preparation.” “If you’re sitting on a merchant cash advance loan right now, you are not stuck.” “Nothing makes me happier than seeing clients realize their dreams and grow into multimillion‑dollar businesses.” “You should talk to multiple lenders—but you should always understand the real cost of the money.” Conclusion Sahra Halpern’s interview serves as a practical roadmap and a cautionary lesson for small business owners navigating today’s uncertain economic landscape. It reinforces that access to capital is about strategy, education, and relationships, not just approval or rejection. The conversation encourages entrepreneurs to reclaim power, avoid predatory financing, and partner with institutions that are committed to their long‑term success and community impact. #SHMS #BEST #STRAWSee omnystudio.com/listener for privacy information.

Chronic Pain, Neuroplasticity, and the Brain's Role in Healing with Dr. Aaron ParkerWhat if chronic pain isn't always a sign of ongoing tissue damage, but rather a learned pattern within the brain and nervous system? In this episode of the Neuroveda Podcast for Complex Health, Gillian Ehrlich sits down with licensed clinical psychologist Dr. Aaron Parker to discuss Pain Reprocessing Therapy (PRT), an evidence-based approach designed to help the brain unlearn chronic pain and persistent symptoms. Together, they explore the neuroscience behind neuroplastic pain, why symptoms can continue long after an injury has healed, and how the brain's interpretation of bodily sensations can influence our experience of pain. The conversation examines the relationship between chronic pain, nervous system regulation, trauma, inflammation, concussion recovery, IBS, migraine, mast cell activation syndrome (MCAS), and long COVID. Dr. Parker explains the concept of somatic tracking, the role of fear and safety in symptom persistence, and how retraining the brain's response to pain can lead to meaningful recovery. Gillian also draws parallels between modern neuroscience and Ayurvedic concepts of intelligence and regulation within the body, creating a fascinating bridge between ancient wisdom and contemporary research. Whether you're living with chronic symptoms, supporting a loved one, or working in healthcare, this episode offers valuable insight into one of the most promising emerging approaches to chronic pain and symptom recovery.In this episode:• What Pain Reprocessing Therapy (PRT) is and how it works• The neuroscience of chronic and neuroplastic pain• Somatic tracking and nervous system regulation• Chronic pain, post-concussion syndrome, IBS, migraine, MCAS, and long COVID• The relationship between emotions, stress, and physical symptoms• How PRT complements other therapeutic approaches• Emerging research on chronic pain recovery and brain plasticity About Our GuestDr. Aaron Parker is a licensed clinical psychologist in Washington State with a background in brain injury rehabilitation and clinical psychology. He has served as an attending psychologist in the University of Washington Department of Rehabilitation Medicine at both Harborview Medical Center and UW Medical Center, where he continues to maintain a clinical faculty appointment. Dr. Parker has supervised psychology trainees, presented research at national conferences, and provides services to accident victims experiencing post-concussion syndrome and post-traumatic stress disorder through the Washington OSIC Concussion TBI Clinic. In his private practice, he specializes in chronic pain, concussion recovery, and neuroplastic symptom treatment, including Pain Reprocessing Therapy.

If you've been doing everything right and still not getting better, this episode was made for you.Dr. Stephanie Canestraro sits down with her colleague and friend, Dr. Christine Schaffner, a naturopathic doctor, bioregulatory medicine expert, and founder of the Sensitive Stack.  She has spent her career on the cutting edge of what it actually takes to heal the patients who fall through every crack in conventional and even functional medicine.At the center of this conversation is a concept that changes everything: sensitivity is a symptom, not a diagnosis. The rising epidemic of mast cell activation syndrome (MCAS), histamine intolerance, long COVID, and chronic multisystem illness isn't happening in a vacuum. It's a signal from the terrain, the extracellular matrix, the autonomic nervous system, the fascia,  that the body's innate intelligence has been blocked. Dr. Christine explains the foundational principles of bioregulatory medicine, which emerged from Switzerland, Austria, and Germany, and why its approach to regulation, terrain theory, and interference fields offers a roadmap that functional medicine alone often misses.One of the most overlooked and most impactful areas they cover is the dental connection. Root canals, amalgam fillings, cavitations, and hidden jaw infections are among the most common interference fields Dr. Christine sees in chronically ill patients. A dead tooth is a chronic infection, and that infection has direct access to the vagus nerve, the lymphatic system, and the organ meridians mapped on the dental chart. Dr. Stephanie shares her own experience supporting a close family member who went from severe anxiety and heart palpitations to calm and functional — simply by removing one infected root canal. Both doctors discuss how to approach dental interventions safely, why preparation and the right biological dentist matter, and how to mitigate the healing response that can follow.The conversation goes deep on hormones, the menstrual cycle, and chronic illness, territory that rarely gets the clinical attention it deserves. Dr. Christine explains what she calls the "luteal phase flare," the week before a woman's period when progesterone drops, prostaglandins rise, and the immune system wakes up to everything it suppressed during the potential implantation window. For women with Lyme disease, mold illness, parasites, or MCAS, this is often the hardest week of the month and it doesn't have to be. They also cover estrogen dominance, beta-glucuronidase, zearalenone (the mold mycotoxin that mimics estrogen), and the liver's central role in hormone metabolism and detoxification.Dr. Christine also shares her own deeply personal journey, navigating a lawsuit, rebuilding her practice, and facing a diagnosis of a 3.2 centimeter pituitary macroadenoma that required brain surgery. In the two weeks between diagnosis and the operating table, she leaned entirely into energy medicine, coherence healings, meditation, and intention work. Her surgeon later told her he'd be studying her tumor for a long time because for its size, it came out unusually easily. Her story is a testament to what's possible when you apply everything you teach.✦ In this episode:• Bioregulatory medicine explained and why it goes beyond functional medicine• Terrain theory vs. germ theory, and what Louis Pasteur said on his deathbed• The extracellular matrix, lymphatic stagnation, and where disease actually begins• Interference fields: scars, hidden infections, and dental toxicity blocking your healing• Root canals, cavitations, and amalgams as chronic infections connected to your organs• MCAS, histamine intolerance, and why sensitivity is a symptom, not a root cause• The luteal phase flare: why women with chronic illness feel worse before their period• Estrogen dominance, zearalenone mold toxin, and beta-glucuronidase• Long COVID, post-vaccine immune dysregulation, and TH1/TH2 immune imbalance• 5G, EMFs, voltage-gated calcium channels, and cell membrane destabilization• Motherwort, hawthorn, and lemon balm as natural calcium channel stabilizers• Dr. Christine's pituitary tumor diagnosis, brain surgery, and healing journey• The Sensitive Stack: Dr. Christine's new program for sensitive, hard-to-treat patients✦ Find Dr. Christine Schaffner:Website: drchristineschaffner.comThe Sensitive Stack: available at her website and on InstagramInstagram: @drchristineschaffner✦ About Dr. Stephanie Canestraro:Dr. Stephanie is a chiropractor, functional medicine practitioner, and chronic illness survivor. What Happens in Vagus explores root-cause healing through the nervous system, bioregulatory medicine, and the extraordinary intelligence of the human body.Let us know your thoughts on this episode hereFor any further information, feel free to email us at info@vagusclinic.com.  Our team is happy to help.  We offer 20-minute complimentary health calls, and you can sign up for one here.

MCAS or histamine intolerance? Discover the 2 MCAS mindsets that can make or break recovery.

Get personalized root-cause care with Empower Functional Health.Learn more at empowerfunctionalhealth.com_____MCAS is often treated like a food problem. But if your “safe food” list keeps getting smaller, restriction may no longer be the solution.In this episode, Judy Cho explains why mast cell activation syndrome is not just about histamine, why food reactions can be a sign of a deeper immune threshold problem, and why the goal is not to fear more foods. The goal is to understand why the body is reacting in the first place.What is MCASCauses of MCAS and histamine flaresMast cell symptomsMast cell activation syndrome, root causeMast cells and the nervous system, stress responseHigh histamine foodsHistamine liberator foodsDAO-blocking foods, the DAO enzymeSupplements, medication supports for MCAS, histaminesMCAS, histamine testingHistamine flares because of Carnivore._____EPISODE RESOURCESMCAS ArticleMCAS Article 2Dr. Tania Dempsey InterviewMCAS studies 1, 2, 3 Personalized Health Plan (symptoms)GI Map stool testComplete Wellness Panel_____WEEKLY NEWSLETTER

What happens when the original voices behind Bendy Bodies come back together 200 episodes later? In this special milestone episode, Dr. Linda Bluestein reunites with her original co-host, dance medicine specialist Jennifer Milner, and the very first guest ever featured on the podcast, Dr. Moira McCormack. Long before hypermobility became a topic of widespread discussion, Dr. McCormack was asking important questions. A former Royal Ballet dancer, former Lead Physiotherapist for The Royal Ballet, and pioneering researcher, she was among the earliest clinicians investigating joint hypermobility in dancers and the challenges that often accompany it. Together, they reflect on more than two decades of progress in our understanding of hypermobility, Ehlers-Danlos syndromes (EDS), and Hypermobility Spectrum Disorders (HSD), while exploring the many misconceptions that still persist today. The conversation goes far beyond flexibility. Dr. McCormack explains why many hypermobile dancers must work harder, recover more strategically, and develop greater body awareness than their peers. The discussion also dives into the often-overlooked multisystem effects of hypermobility, including fatigue, pain, dysautonomia, gastrointestinal symptoms, and mast cell activation syndrome (MCAS). Drawing on decades of experience working with elite dancers and hypermobile patients, Dr. McCormack shares practical insights on injury prevention, individualized rehabilitation, hands-on assessment, and the art of teaching movement with patience and precision. Whether you're a dancer, athlete, parent, teacher, clinician, or someone navigating hypermobility yourself, this episode offers both a fascinating look at how far the field has come and a roadmap for where we still need to go. Most importantly, it reminds us that success in a hypermobile body isn't about having the most flexibility. It's about developing the control, strength, awareness, and resilience to use that flexibility well. Key Takeaways • This episode reunites the same three people who launched Bendy Bodies with Episode 1, creating a full-circle conversation 200 episodes later. • Hypermobile dancers often work harder behind the scenes than audiences realize. Fatigue, recovery, and injury prevention are frequently bigger challenges than flexibility itself. • Flexibility without control can increase injury risk. Strength, stability, motor control, and body awareness are essential for long-term success. • Hypermobility can affect far more than the joints, contributing to symptoms involving the nervous system, gastrointestinal tract, immune system, and cardiovascular system. • Rehabilitation is rarely one-size-fits-all. Hypermobile individuals often benefit from individualized assessment, hands-on treatment, and slower, more deliberate progression. • Teachers, parents, and healthcare professionals play a critical role in recognizing early warning signs and supporting healthy development in young dancers. • One of the most powerful injury-prevention strategies may be surprisingly simple: learning to master posture and alignment before adding movement. • Moira also honors the influence of the late Professor Rodney Grahame, with whom she conducted her early research and met frequently to discuss joint hypermobility, connective tissue disorders, and the many unanswered questions that continue to shape the field today. Find the episode transcript here. Go to AirDoctorPro.com and use promo code BENDY_ to get UP TO $300 off today! Want more Jennifer Milner? Instagram: @jennifer.milner Website: https://www.jennifer-milner.com/ Want more Dr. Moira McCormack? https://iseh.co.uk/member/moira-mccormack Want more Dr. Linda Bluestein, MD? Website: https://www.hypermobilitymd.com/ YouTube: https://www.youtube.com/@bendybodiespodcast Instagram: ⁠⁠⁠⁠https://www.instagram.com/hypermobilitymd/⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠https://www.facebook.com/BendyBodiesPodcast⁠⁠⁠⁠ X: ⁠⁠⁠⁠https://twitter.com/BluesteinLinda⁠⁠⁠⁠ LinkedIn: ⁠⁠⁠⁠https://www.linkedin.com/in/hypermobilitymd/⁠⁠⁠⁠ Newsletter: ⁠⁠⁠⁠https://hypermobilitymd.substack.com/ Shop my Amazon store ⁠⁠⁠ https://www.amazon.com/shop/hypermobilitymd Dr. Bluestein's Recommended Herbs, Supplements and Care Necessities: https://us.fullscript.com/welcome/hypermobilitymd/store-start Want to learn more about the UVA EDS Center? For Appointments and Questions: RUVAEDSCenter@uvahealth.org UVA EDS: https://www.uvahealth.com/healthy-practice/advancing-care-through-ehlers-danlos-clinic UVA EDS FAQ: https://www.uvahealth.com/support/eds/faq UVA Pediatric Integrative Medicine: https://childrens.uvahealth.com/specialties/integrative-health Thank YOU so much for tuning in. We hope you found this episode informative, inspiring, useful, validating, and enjoyable. Join us on the next episode for YOUR time to level up your knowledge about hypermobility disorders and the people who have them. Join YOUR Bendy Bodies community at ⁠⁠https://www.bendybodiespodcast.com/⁠⁠. YOUR bendy body is our highest priority!⁠⁠ Learn more about Human Content at ⁠⁠⁠http://www.human-content.com⁠⁠⁠ Podcast Advertising/Business Inquiries: ⁠⁠⁠sales@human-content.com⁠⁠⁠ Part of the Human Content Podcast Network FTC: This video is not sponsored. Links are commissionable, meaning I may earn commission from purchases made through links Learn more about your ad choices. Visit megaphone.fm/adchoices

What happens when the original voices behind Bendy Bodies come back together 200 episodes later? In this special milestone episode, Dr. Linda Bluestein reunites with her original co-host, dance medicine specialist Jennifer Milner, and the very first guest ever featured on the podcast, Dr. Moira McCormack. Long before hypermobility became a topic of widespread discussion, Dr. McCormack was asking important questions. A former Royal Ballet dancer, former Lead Physiotherapist for The Royal Ballet, and pioneering researcher, she was among the earliest clinicians investigating joint hypermobility in dancers and the challenges that often accompany it. Together, they reflect on more than two decades of progress in our understanding of hypermobility, Ehlers-Danlos syndromes (EDS), and Hypermobility Spectrum Disorders (HSD), while exploring the many misconceptions that still persist today. The conversation goes far beyond flexibility. Dr. McCormack explains why many hypermobile dancers must work harder, recover more strategically, and develop greater body awareness than their peers. The discussion also dives into the often-overlooked multisystem effects of hypermobility, including fatigue, pain, dysautonomia, gastrointestinal symptoms, and mast cell activation syndrome (MCAS). Drawing on decades of experience working with elite dancers and hypermobile patients, Dr. McCormack shares practical insights on injury prevention, individualized rehabilitation, hands-on assessment, and the art of teaching movement with patience and precision. Whether you're a dancer, athlete, parent, teacher, clinician, or someone navigating hypermobility yourself, this episode offers both a fascinating look at how far the field has come and a roadmap for where we still need to go. Most importantly, it reminds us that success in a hypermobile body isn't about having the most flexibility. It's about developing the control, strength, awareness, and resilience to use that flexibility well. Key Takeaways • This episode reunites the same three people who launched Bendy Bodies with Episode 1, creating a full-circle conversation 200 episodes later. • Hypermobile dancers often work harder behind the scenes than audiences realize. Fatigue, recovery, and injury prevention are frequently bigger challenges than flexibility itself. • Flexibility without control can increase injury risk. Strength, stability, motor control, and body awareness are essential for long-term success. • Hypermobility can affect far more than the joints, contributing to symptoms involving the nervous system, gastrointestinal tract, immune system, and cardiovascular system. • Rehabilitation is rarely one-size-fits-all. Hypermobile individuals often benefit from individualized assessment, hands-on treatment, and slower, more deliberate progression. • Teachers, parents, and healthcare professionals play a critical role in recognizing early warning signs and supporting healthy development in young dancers. • One of the most powerful injury-prevention strategies may be surprisingly simple: learning to master posture and alignment before adding movement. • Moira also honors the influence of the late Professor Rodney Grahame, with whom she conducted her early research and met frequently to discuss joint hypermobility, connective tissue disorders, and the many unanswered questions that continue to shape the field today. Find the episode transcript here. Go to AirDoctorPro.com and use promo code BENDY_ to get UP TO $300 off today! Want more Jennifer Milner? Instagram: @jennifer.milner Website: https://www.jennifer-milner.com/ Want more Dr. Moira McCormack? https://iseh.co.uk/member/moira-mccormack Want more Dr. Linda Bluestein, MD? Website: https://www.hypermobilitymd.com/ YouTube: https://www.youtube.com/@bendybodiespodcast Instagram: ⁠⁠⁠⁠https://www.instagram.com/hypermobilitymd/⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠https://www.facebook.com/BendyBodiesPodcast⁠⁠⁠⁠ X: ⁠⁠⁠⁠https://twitter.com/BluesteinLinda⁠⁠⁠⁠ LinkedIn: ⁠⁠⁠⁠https://www.linkedin.com/in/hypermobilitymd/⁠⁠⁠⁠ Newsletter: ⁠⁠⁠⁠https://hypermobilitymd.substack.com/ Shop my Amazon store ⁠⁠⁠ https://www.amazon.com/shop/hypermobilitymd Dr. Bluestein's Recommended Herbs, Supplements and Care Necessities: https://us.fullscript.com/welcome/hypermobilitymd/store-start Want to learn more about the UVA EDS Center? For Appointments and Questions: RUVAEDSCenter@uvahealth.org UVA EDS: https://www.uvahealth.com/healthy-practice/advancing-care-through-ehlers-danlos-clinic UVA EDS FAQ: https://www.uvahealth.com/support/eds/faq UVA Pediatric Integrative Medicine: https://childrens.uvahealth.com/specialties/integrative-health Thank YOU so much for tuning in. We hope you found this episode informative, inspiring, useful, validating, and enjoyable. Join us on the next episode for YOUR time to level up your knowledge about hypermobility disorders and the people who have them. Join YOUR Bendy Bodies community at ⁠⁠https://www.bendybodiespodcast.com/⁠⁠. YOUR bendy body is our highest priority!⁠⁠ Learn more about Human Content at ⁠⁠⁠http://www.human-content.com⁠⁠⁠ Podcast Advertising/Business Inquiries: ⁠⁠⁠sales@human-content.com⁠⁠⁠ Part of the Human Content Podcast Network FTC: This video is not sponsored. Links are commissionable, meaning I may earn commission from purchases made through links Learn more about your ad choices. Visit megaphone.fm/adchoices

The kidneys are a major detox organ and are often overlooked or ignored entirely by most practitioners. In this episode I chat about the importance of the kidneys, how they work, signs they may need a detox and detos and drainage tips.Equip Grass fed protein: www.equipfoods.com/MARLA60 Day Gut Reset ($200 OFF) - https://checkout.teachable.com/secure/1716725/checkout/order_52y48hdz?coupon_code=SECRETOFFER

In this episode of Resiliency Radio with Dr. Jill, Dr. Jill Carnahan welcomes Dr. Jaban Moore for an in-depth discussion on the hidden drivers behind chronic illness, including mold toxicity, Lyme disease, parasites, trauma, and nervous system dysfunction. Drawing from his own journey through chronic illness, Dr. Moore shares how environmental toxins, infections, and unresolved stress can create a perfect storm of inflammation and immune dysregulation. Together, they explore why so many patients remain stuck despite treatment and what it takes to create a foundation for true healing. This conversation offers practical insights into detoxification, nervous system regulation, parasite protocols, peptide therapies, and creating an internal environment where the body can finally recover.

Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

Summer can bring unique challenges for people living with Mast Cell Disease. From heat and travel to outdoor activities, how can you enjoy the season while managing symptoms? Join us as we sit down with content creator and patient advocate, Jenna Gestetner, to share practical tips for navigating summer with confidence. Resources to keep you in the know:Mast Cell Disease SocietyFAACT's Allergy SummitJennaXHealthInstagram: JennaXHealthTikTok: JennaXHealthYouTube: JennXHealthLinkedIn: Jenna GestetnerYou can find FAACT's Roundtable Podcast on Apple Podcasts, Pandora, Spotify, Podbay, iHeart Radio, or wherever you listen to podcasts.Follow us on Facebook, Instagram, BlueSky, Threads, LinkedIn, Pinterest, TikTok, and YouTube.Sponsored by: Blueprint MedicinesThanks for listening! FAACT invites you to discover more exciting food allergy resources at FoodAllergyAwareness.org!

This is my personal favorite topic, but probably your least favorite: strength training.  Before you run away, hear me out! Because whether you’re bed-bound, housebound, or just convinced your body can’t handle it right now, this episode is for you. I’m breaking down exactly WHY resistance and strength training isn’t just helpful for vestibular disorders—it’s essential.  You Have to Move Your Body to Manage Your Dizziness From the dizzy-anxious-dizzy cycle to blood sugar regulation to better sleep to reduced inflammation, strength training touches virtually every struggle vestibular warriors face. I’m not letting anyone off the hook, but I am meeting you exactly where you are. Starting with 3 minutes? That counts.  Walking to the mailbox and back? That counts too.  Because the goal here is progress, not perfection. And you know I have the science to back every single word of it! In this episode, we'll dig into: Why strength training is non-negotiable for vestibular disorder management How exercise helps break the dizzy-anxious-dizzy cycle “In the moment” vs. “hangover” dizziness and how to adjust your approach Why EDS, HSD, or MCAS makes building muscle even more critical The truth about the fear of getting “bulky” How to start exercising when you’re bedbound or couch-bound What physical activity guidelines actually say, and where most people fall short How functional movements like the deadlift directly support vestibular patients How Vestibular Group Fit makes strength and resistance training accessible Whether you start with 3 minutes or 30, the most important thing is that you start. Because your vestibular system, your mood, your balance, and your future self are all counting on it. Links Mentioned: Vestibular Group Fit (code GROUNDED at checkout for 15% off!): https://thevertigodoctor.com/vestibular-group-fit Free Resources: ⁠The 4 Steps to Managing Vestibular Migraine: https://thevertigodoctor.myflodesk.com/cb5js0y78n ⁠The PPPD Management Masterclass⁠: https://thevertigodoctor.myflodesk.com/new-pppd ⁠What your Partner Should Know About Living with Dizziness⁠: https://thevertigodoctor.myflodesk.com/partnership ⁠The FREE Mini VGFit Workout⁠: https://thevertigodoctor.myflodesk.com/minifit ⁠The FREE POTS – safe Workouts⁠: https://thevertigodoctor.myflodesk.com/pots Connect with Dr. Madison (@TheVertigoDoctor): https://instagram.com/thevertigodoctor Work with Dr. Madison: For 1:1 Vestibular Rehabilitation Therapy, email madison@thevertigodoctor.com Otherwise, I'll see ya in Vestibular Group Fit! Connect with Dr. Jenna (@dizzy.rehab.therapist): https://www.instagram.com/dizzy.rehab.therapist/ Learn about the Oak Method: http://thevertigodoctor.com/why-vestibular-group-fit Citations: Adriano Oliveira, Andressa Fidalgo, Paulo Farinatti, Walace Monteiro,Effects of high-intensity interval and continuous moderate aerobic training on fitness and health markers of older adults: A systematic review and meta-analysis,Archives of Gerontology and Geriatrics,Volume 124,2024,105451,ISSN 0167-4943,https://doi.org/10.1016/j.archger.2024.105451.(https://www.sciencedirect.com/science/article/pii/S0167494324001274) Yu Y, Wang J, Xu J. Optimal dose and type of exercise to improve cognitive function in patients with mild cognitive impairment: a systematic review and network meta-analysis of RCTs. Front Psychiatry. 2024 Sep 12;15:1436499. doi: 10.3389/fpsyt.2024.1436499. PMID: 39328348; PMCID: PMC11424528. Zhang Y, Zhou M, Yin Z, Zhuang W, Wang Y. Relationship between physical activities and mental health in older people: a bibliometric analysis. Front Psychiatry. 2024 Oct 21;15:1424745. doi: 10.3389/fpsyt.2024.1424745. PMID: 39497901; PMCID: PMC11532734. Garcia Meneguci, C. A., Meneguci, J., Sasaki, J. E., Tribess, S., & Júnior, J. S. V. (2021). Physical activity, sedentary behavior and functionality in older adults: A cross-sectional path analysis. PloS one, 16(1), e0246275. https://doi.org/10.1371/journal.pone.0246275 Mennitti C, Farina G, Imperatore A, De Fonzo G, Gentile A, La Civita E, Carbone G, De Simone RR, Di Iorio MR, Tinto N, Frisso G, D’Argenio V, Lombardo B, Terracciano D, Crescioli C, Scudiero O. How Does Physical Activity Modulate Hormone Responses? Biomolecules. 2024 Nov 7;14(11):1418. doi: 10.3390/biom14111418. PMID: 39595594; PMCID: PMC11591795. Beavers KM, Brinkley TE, Nicklas BJ. Effect of exercise training on chronic inflammation. Clin Chim Acta. 2010 Jun 3;411(11-12):785-93. doi: 10.1016/j.cca.2010.02.069. Epub 2010 Feb 25. PMID: 20188719; PMCID: PMC3629815.  Chastin, S.F.M., Abaraogu, U., Bourgois, J.G. et al. Effects of Regular Physical Activity on the Immune System, Vaccination and Risk of Community-Acquired Infectious Disease in the General Population: Systematic Review and Meta-Analysis. Sports Med 51, 1673–1686 (2021). https://doi.org/10.1007/s40279-021-01466-1 Hoffman GJ, Malani PN, Solway E, Kirch M, Singer DC, Kullgren JT. Changes in activity levels, physical functioning, and fall risk during the COVID-19 pandemic. J Am Geriatr Soc. 2022 Jan;70(1):49-59. doi: 10.1111/jgs.17477. Epub 2021 Sep 24. PMID: 34536288. Rey-Lopez JP, Rimm EB, Tabung FK, Giovannucci EL. Long-Term Leisure-Time Physical Activity Intensity and All-Cause and Cause-Specific Mortality: A Prospective Cohort of US Adults. Circulation. 2022 Aug 16;146(7):523-534. doi: 10.1161/CIRCULATIONAHA.121.058162. Epub 2022 Jul 25. PMID: 35876019; PMCID: PMC9378548. Hupin D, Roche F, Gremeaux V, Chatard JC, Oriol M, Gaspoz JM, Barthélémy JC, Edouard P. Even a low-dose of moderate-to-vigorous physical activity reduces mortality by 22% in adults aged ≥60 years: a systematic review and meta-analysis. Br J Sports Med. 2015 Oct;49(19):1262-7. doi: 10.1136/bjsports-2014-094306. Epub 2015 Aug 3. PMID: 26238869. Chandrasekaran B, Ganesan TB. Sedentarism and chronic disease risk in COVID 19 lockdown – a scoping review. Scott Med J. 2021 Feb;66(1):3-10. doi: 10.1177/0036933020946336. Epub 2020 Jul 27. PMID: 32718266; PMCID: PMC8685753. Izquierdo M, Merchant RA, Morley JE, Anker SD, Aprahamian I, Arai H, Aubertin-Leheudre M, Bernabei R, Cadore EL, Cesari M, Chen LK, de Souto Barreto P, Duque G, Ferrucci L, Fielding RA, García-Hermoso A, Gutiérrez-Robledo LM, Harridge SDR, Kirk B, Kritchevsky S, Landi F, Lazarus N, Martin FC, Marzetti E, Pahor M, Ramírez-Vélez R, Rodriguez-Mañas L, Rolland Y, Ruiz JG, Theou O, Villareal DT, Waters DL, Won Won C, Woo J, Vellas B, Fiatarone Singh M. International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines. J Nutr Health Aging. 2021;25(7):824-853. doi: 10.1007/s12603-021-1665-8. PMID: 34409961; PMCID: PMC12369211. Bunnell E, Stratton MT. The Impact of Functional Training on Balance and Vestibular Function: A Narrative Review. J Funct Morphol Kinesiol. 2024 Dec 3;9(4):251. doi: 10.3390/jfmk9040251. PMID: 39728235; PMCID: PMC11679947. Caspersen CJ, Powell KE, Christenson GM. Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. Public Health Rep. 1985 Mar-Apr;100(2):126-31. PMID: 3920711; PMCID: PMC1424733. Warner A, Vanicek N, Benson A, Myers T, Abt G. Agreement and relationship between measures of absolute and relative intensity during walking: A systematic review with meta-regression. PLoS One. 2022 Nov 3;17(11):e0277031. doi: 10.1371/journal.pone.0277031. PMID: 36327341; PMCID: PMC9632890. “Metabolic Equivalent (MET): Pick the Best Exercise for Longevity.” Whyiexercise.com, www.whyiexercise.com/metabolic-equivalent.html. Love what you heard?Consider leaving a review on your favorite podcast platform to help us reach more vestibular warriors like you! This podcast is for informational purposes only and may not be the best fit for you and your personal situation. It shall not be construed as medical advice. The information and education provided here is not intended or implied to supplement or replace professional medical treatment, advice, and/or diagnosis. Always check with your own physician or medical professional before trying or implementing any information read here. ————————————— strength and resistance training, exercises for vestibular disorders, living with vestibular migraine, guidelines of physical activity, anxiety and depression, chronic dizziness, couch bound, bed bound, dizzy-anxious-dizzy cycle, physical therapist

Today we're diving into part one of a two part series conversation that has absolutely exploded across social media, comment sections, and private messages. The Pepcid and Allegra conversation. Maybe you've heard of it. Maybe this is something new. Unveiled today. If you've been anywhere online lately, you've probably seen women talking about Pepcid and Allegra for Pmdd. Some women are reporting dramatic improvements in mood, anxiety, irritability, rage, overwhelm, breast tenderness, bloating, headaches, and a variety of symptoms that seem to intensify around their cycle. And I'm glad this conversation is happening. Pmdd. Perimenopause and histamine drive the spotlight here for a moment, because the majority of women are struggling or will struggle with these in their lifetime, whether they know it or not. For far too long, many women thought their symptoms were simply stress, allergies, aging, anxiety, part of being a woman, or something they should learn to live with. What concerns me isn't that women are talking about Pepcid and Allegra. What concerns me is that most of the information being shared is only a small piece of a much larger physiological picture, as you can imagine. And if you're someone who has already purchased these medications, started the protocol, or you're considering trying it after hearing somebody rave about it online in a thirty second Tik Tok, I want you to stay with me through this entire episode because context matters as always. Today we're going to talk about Pmdd, perimenopause, histamine mast cell activation syndrome, often called MCAs. We're going to talk about vagus nerve and neuroinflammation. We're going to talk about estrogen and why so many women are experiencing symptoms that they never connect back to hormones. And most importantly, we're going to talk about why Pepcid may be helping some women and why the explanation being circulated online is often incomplete.    Time Stamps:   (1:10) The Pepcid + Allegra Trend (2:20) What We'll Cover (9:15) Histamine Is Not The Enemy (13:47) What The Research Is Showing (17:00) Vagal Nerve Stimulation (18:45) Where Symptoms Develop (22:25) Perimenopause and HRT (31:20) Please Share This Episode ----------  Apply for SF Coaching Method  https://sarahfechter.ac-page.com/sfhq-cc Complimentary Health Content  https://sarahfechter.ac-page.com/Health_Wellness_Community ----------  Follow Me On Instagram - https://www.instagram.com/sarahfechter.ifbbpro/   Check Out My Website - https://www.sarahfechter.com ----------  This Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, other professional health care services, or any professional practice of any kind. Any reliance on the information provided in this Podcast is done at your own risk and Sarah Fechter Fitness LLC expressly disclaims any and all liability or responsibility for any direct, indirect, incidental, special, consequential or other damages arising out of any individual use of, reference to, reliance on, or inability to use, this Podcast or the information presented in this Podcast. All contents and design for this Podcast are owned by Sarah Fechter Fitness LLC. Always consult your professional team before beginning any exercise or nutrition program.

Have you reached the point where you're constantly bracing for your next symptom? Even simple things like eating something you've eaten before, or having a busy day at work, fill your mind with the worry: "Is this going to set my body off again?" If you've been dealing with brain fog, bloating, skin reactions, fatigue, anxiety, heart palpitations, or other symptoms that seem to come out of nowhere, you know how exhausting it can be to lose trust in your own body. In this episode of The Health Made Simple Show, Dr. Bart explores one of the most overlooked pieces of the puzzle behind Mast Cell Activation Syndrome (MCAS): the relationship between chronic stress, your nervous system, and your immune system. Because while foods, toxins, and environmental triggers certainly matter, your body can only stay in a constant state of fight-or-flight for so long before the immune system itself begins to change. In this episode, you'll learn: Why chronic stress can quietly dysregulate your immune system The connection between stress and MCAS symptoms How cortisol, adrenaline, blood sugar, and inflammation work together Why your body can become more reactive over time The difference between living in fight-or-flight versus the body's natural healing state   Plus, Dr. Bart shares the same therapies he's used to help hundreds of people shift their bodies back into a healing state. If you've been trying to avoid every trigger but still don't feel like yourself, this episode will help you start seeing the bigger picture.

Last year, I received an email from a lovely individual inquiring about coaching opportunities. I asked if she could briefly share her story and some of her goals for coaching. In true autistic style, she replied with what she described as “a novel to explain herself, lol.” I loved reading this “novel” because, as with most emails I receive, I resonated with so much of her lived experience. In her email, this individual shared how she had struggled with disordered eating for most of her life. At age 46, she was diagnosed with autism, which she said was “life-changing in ways I can't even begin to describe.” Over the years, she'd tried countless “treatments” for her eating challenges – but as I'm sure you can already guess, these attempts had not only failed, but led to feelings of hopelessness. The reason I reflect on this correspondence is because there was one sentence in her email that I immediately thought of after I recorded today's podcast episode. She wrote that she'd been scouring the internet for links between autism and overeating, but ended up finding very little that resonated. “It's all about ARFID and beige food and anorexia,” she wrote. And she's right; there is very little out there on the connection between autism and binge eating, which is why I am BEYOND excited to be diving into this conversation with my good friend Kory Andreas on the podcast today! After we talk about the lost generation of autistic relatives and how our grandmas are basically the same person, Kory opens up about her MCAS (Mast Cell Activation Syndrome) which is super common in neurodivergent people. Kory also talks about her experience with binge eating, learning that it was rooted in being neurodivergent, and how starting ADHD medication practically made all her binge urges disappear overnight. This was such a high energy conversation (I mean, just put two neurodivergent people in a room together, right?) so I can't wait for you to listen!

Could one of the most overlooked drivers of chronic pain, fatigue, poor sleep, and slow recovery be hiding in plain sight? In this episode, Dr. Linda Bluestein and co-host Dr. Dacre Knight sit down with integrative medicine pioneer Dr. Gregory Plotnikoff to unpack why Vitamin D may be one of the most important, misunderstood, and cost-effective interventions in modern medicine. But this conversation goes far beyond bone health. Dr. Plotnikoff explains why Vitamin D functions more like a hormone than a vitamin, influencing over 2,000 genes tied to immune function, mood, sleep, inflammation, muscle health, and pain regulation. Together, they explore why profound deficiencies are shockingly common, even in sunny climates, and how low levels may contribute to chronic musculoskeletal pain, tendinopathies, stress fractures, fatigue, and complex chronic illness. The discussion also dives into practical, foundational medicine for patients with Ehlers-Danlos Syndromes (EDS), POTS (postural orthostatic tachycardia syndrome), MCAS (mast cell activation syndrome), chronic pain, and other multisystem conditions, including the “Top 5” lab tests Dr. Plotnikoff believes are essential for understanding the bigger picture of health. If you've ever been told your labs are “normal” while still feeling awful, this episode may change how you think about chronic illness and foundational health. Takeaways: • Vitamin D is actually a hormone that regulates gene expression affecting pain, sleep, energy, immunity, and bone health. • Chronic musculoskeletal pain, stress fractures, and tendon problems may sometimes be linked to severe Vitamin D deficiency. • Many people remain profoundly deficient despite living in sunny climates because Vitamin D synthesis is blocked by glass, sunscreen, clothing, and indoor lifestyles. • Vitamin D dosing is often weight-dependent, meaning some individuals require significantly higher doses to reach adequate levels. • Dr. Plotnikoff's “Top 5” foundational labs for complex chronic illness include: Find the episode transcript here. Go to AirDoctorPro.com and use promo code BENDY_ to get UP TO $300 off today! Want more Dr. Gregory Plotnikoff? www.MNpersonalizedmedicine.com Want to learn more about the UVA EDS Center? For Appointments and Questions: RUVAEDSCenter@uvahealth.org UVA EDS: https://www.uvahealth.com/healthy-practice/advancing-care-through-ehlers-danlos-clinic UVA EDS FAQ: https://www.uvahealth.com/support/eds/faq UVA Pediatric Integrative Medicine: https://childrens.uvahealth.com/specialties/integrative-health Thank YOU so much for tuning in. We hope you found this episode informative, inspiring, useful, validating, and enjoyable. Join us on the next episode for YOUR time to level up your knowledge about hypermobility disorders and the people who have them. Want more Dr. Linda Bluestein, MD? Website: https://www.hypermobilitymd.com/ YouTube: https://www.youtube.com/@bendybodiespodcast Instagram: ⁠⁠⁠⁠https://www.instagram.com/hypermobilitymd/⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠https://www.facebook.com/BendyBodiesPodcast⁠⁠⁠⁠ X: ⁠⁠⁠⁠https://twitter.com/BluesteinLinda⁠⁠⁠⁠ LinkedIn: ⁠⁠⁠⁠https://www.linkedin.com/in/hypermobilitymd/⁠⁠⁠⁠ Newsletter: ⁠⁠⁠⁠https://hypermobilitymd.substack.com/ Shop my Amazon store ⁠⁠⁠ https://www.amazon.com/shop/hypermobilitymd Dr. Bluestein's Recommended Herbs, Supplements and Care Necessities: https://us.fullscript.com/welcome/hypermobilitymd/store-start Join YOUR Bendy Bodies community at ⁠⁠https://www.bendybodiespodcast.com/⁠⁠. YOUR bendy body is our highest priority!⁠⁠ Learn more about Human Content at ⁠⁠⁠http://www.human-content.com⁠⁠⁠ Podcast Advertising/Business Inquiries: ⁠⁠⁠sales@human-content.com⁠⁠⁠ Part of the Human Content Podcast Network FTC: This video is not sponsored. Links are commissionable, meaning I may earn commission from purchases made through links Learn more about your ad choices. Visit megaphone.fm/adchoices

Episode 171 — Why does one patient get a breast implant and feel fine, while another spirals into fatigue, brain fog, joint pain, and a diagnosis no one can explain? The answer may lie in mast cells. In this episode, Dr. Robert Whitfield sits down with Dr. Tania Dempsey — one of the country's leading experts in Mast Cell Activation Syndrome (MCAS) — to explore a connection that most physicians are not trained to recognize: the relationship between implantable devices, chronic immune activation, and conditions like MCAS, POTS, and hypermobility syndrome. What you'll learn in this episode: What Mast Cell Activation Syndrome (MCAS) actually is — and why up to 20% of the population may have it The top 10 symptoms MCAS patients present with, from fatigue and brain fog to fibromyalgia and food sensitivities Why the MCAS, POTS, and hypermobility triad appears so frequently together How breast implants interact with the immune system at the tissue level — including new research showing an upregulated plasma cell and B-cell response in certain patients The role of biofilm, bacterial contamination (Staph epidermidis & Cutibacterium acnes), and oxylipin 10-HOME in driving chronic inflammation Why GLP-1 medications are showing surprising results in MCAS patients How mold, glyphosate, organophosphates, and hormonal changes can trigger or worsen MCAS Practical, low-cost steps to begin lowering your baseline inflammation today How anesthesia teams can reduce MCAS-related risk during explant surgery This conversation bridges two specialties that rarely share the same stage — reconstructive plastic surgery and immunology — because the patient population increasingly demands it. Whether you are navigating unexplained symptoms, considering explant surgery, or simply want to understand why some bodies react so differently to the same devices and environments, this episode provides a clinically grounded, measured, and actionable framework. Connect with Dr. Tania Dempsey: Instagram: @drtaniadempsey | Podcast: Mast Cell Matters | Website: drtaniadempsey.com Connect with Dr. Robert Whitfield:

Could one of the most overlooked drivers of chronic pain, fatigue, poor sleep, and slow recovery be hiding in plain sight? In this episode, Dr. Linda Bluestein and co-host Dr. Dacre Knight sit down with integrative medicine pioneer Dr. Gregory Plotnikoff to unpack why Vitamin D may be one of the most important, misunderstood, and cost-effective interventions in modern medicine. But this conversation goes far beyond bone health. Dr. Plotnikoff explains why Vitamin D functions more like a hormone than a vitamin, influencing over 2,000 genes tied to immune function, mood, sleep, inflammation, muscle health, and pain regulation. Together, they explore why profound deficiencies are shockingly common, even in sunny climates, and how low levels may contribute to chronic musculoskeletal pain, tendinopathies, stress fractures, fatigue, and complex chronic illness. The discussion also dives into practical, foundational medicine for patients with Ehlers-Danlos Syndromes (EDS), POTS (postural orthostatic tachycardia syndrome), MCAS (mast cell activation syndrome), chronic pain, and other multisystem conditions, including the “Top 5” lab tests Dr. Plotnikoff believes are essential for understanding the bigger picture of health. If you've ever been told your labs are “normal” while still feeling awful, this episode may change how you think about chronic illness and foundational health. Takeaways: • Vitamin D is actually a hormone that regulates gene expression affecting pain, sleep, energy, immunity, and bone health. • Chronic musculoskeletal pain, stress fractures, and tendon problems may sometimes be linked to severe Vitamin D deficiency. • Many people remain profoundly deficient despite living in sunny climates because Vitamin D synthesis is blocked by glass, sunscreen, clothing, and indoor lifestyles. • Vitamin D dosing is often weight-dependent, meaning some individuals require significantly higher doses to reach adequate levels. • Dr. Plotnikoff's “Top 5” foundational labs for complex chronic illness include: Find the episode transcript here. Go to AirDoctorPro.com and use promo code BENDY_ to get UP TO $300 off today! Want more Dr. Gregory Plotnikoff? www.MNpersonalizedmedicine.com Want to learn more about the UVA EDS Center? For Appointments and Questions: RUVAEDSCenter@uvahealth.org UVA EDS: https://www.uvahealth.com/healthy-practice/advancing-care-through-ehlers-danlos-clinic UVA EDS FAQ: https://www.uvahealth.com/support/eds/faq UVA Pediatric Integrative Medicine: https://childrens.uvahealth.com/specialties/integrative-health Thank YOU so much for tuning in. We hope you found this episode informative, inspiring, useful, validating, and enjoyable. Join us on the next episode for YOUR time to level up your knowledge about hypermobility disorders and the people who have them. Want more Dr. Linda Bluestein, MD? Website: https://www.hypermobilitymd.com/ YouTube: https://www.youtube.com/@bendybodiespodcast Instagram: ⁠⁠⁠⁠https://www.instagram.com/hypermobilitymd/⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠https://www.facebook.com/BendyBodiesPodcast⁠⁠⁠⁠ X: ⁠⁠⁠⁠https://twitter.com/BluesteinLinda⁠⁠⁠⁠ LinkedIn: ⁠⁠⁠⁠https://www.linkedin.com/in/hypermobilitymd/⁠⁠⁠⁠ Newsletter: ⁠⁠⁠⁠https://hypermobilitymd.substack.com/ Shop my Amazon store ⁠⁠⁠ https://www.amazon.com/shop/hypermobilitymd Dr. Bluestein's Recommended Herbs, Supplements and Care Necessities: https://us.fullscript.com/welcome/hypermobilitymd/store-start Join YOUR Bendy Bodies community at ⁠⁠https://www.bendybodiespodcast.com/⁠⁠. YOUR bendy body is our highest priority!⁠⁠ Learn more about Human Content at ⁠⁠⁠http://www.human-content.com⁠⁠⁠ Podcast Advertising/Business Inquiries: ⁠⁠⁠sales@human-content.com⁠⁠⁠ Part of the Human Content Podcast Network FTC: This video is not sponsored. Links are commissionable, meaning I may earn commission from purchases made through links Learn more about your ad choices. Visit megaphone.fm/adchoices

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What if your brain fog, bloating, fatigue, anxiety, skin reactions, and heart palpitations aren't separate problems at all? Most people look at these symptoms one at a time. They try a supplement for digestion… Something else for energy… A new diet for inflammation… Or they visit different specialists for each symptom… But Dr. Bart knows these seemingly unrelated issues are usually connected. So in this episode of The Health Made Simple Show, Dr. Bart breaks down Mast Cell Activation Syndrome (MCAS) and explains why it's becoming one of the most overlooked drivers of chronic symptoms. You'll learn: What MCAS actually is and why it's becoming more common Why symptoms can appear in multiple body systems at the same time The four major root causes that can drive mast cell dysfunction Why standard testing often fails to identify the issue How stress and nervous system dysregulation can amplify symptoms The role mold, toxins, and environmental exposures may be playing The first step Dr. Bart recommends for calming an overwhelmed system If you've been struggling with symptoms that don't seem to make sense together, this episode will help you start connecting the dots.

In this special replay, BS Free MD host Dr. May Hindmarsh steps out from behind the microphone and into the guest chair. Originally recorded for the Hotflash Inc. podcast with host Anne-Marie McQueen, this candid conversation explores Dr. May's personal journey through menopause, hormone therapy, histamine intolerance, epigenetics, and the unexpected challenges she faced when conventional solutions didn't provide the answers she was seeking. After more than 30 years practicing medicine, Dr. May found herself navigating a complex health journey that included severe hot flashes, migraines, sleep disruption, anxiety, panic attacks, elevated heart rate, and symptoms that persisted despite hormone replacement therapy. As both physician and patient, she began asking deeper questions about genetics, hormone metabolism, mast cell activation, and individualized care. Together, Anne-Marie and Dr. May discuss the importance of critical thinking in medicine, the dangers of one-size-fits-all approaches, and why listening to your own body may be one of the most important skills in healthcare. In This Episode Why Dr. May and Dr. Tim launched BS Free MD Lessons learned from practicing medicine through the COVID era What happened when hormone therapy stopped working as expected Histamine intolerance and mast cell activation explained The role of MTHFR, COMT, and epigenetics in hormone metabolism Why some women thrive on hormone therapy while others struggle Trauma, stress, and their impact on health outcomes The growing movement toward personalized medicine How to navigate conflicting health information Learning to trust your body's signals About Dr. May Hindmarsh Dr. May Hindmarsh is a retired family physician with more than three decades of experience practicing medicine in Canada and the United States. Alongside her husband, Dr. Tim Hindmarsh, she co-hosts BS Free MD, where they challenge conventional narratives, explore emerging health topics, and encourage listeners to think critically about medicine, wellness, and personal responsibility. Original Interview This episode originally aired on the Hotflash Inc. podcast and is being republished on BS Free MD with permission. Connect with BS Free MD Website: https://www.bsfreemd.com Podcast: https://www.bsfreemd.com/podcast YouTube: https://www.youtube.com/@BSFreeMD Disclaimer The information shared in this episode is for educational and informational purposes only and should not be considered medical advice. Always consult your healthcare professional regarding your individual health needs.

MCAS is one of those diagnoses that can make it feel like your body is telling a dozen stories at once—and no one is listening. If you're experiencing GI symptoms alongside flushing, hives, brain fog, fatigue, palpitations, medication sensitivities, or a persistent "fight-or-flight" feeling, this episode is designed to help connect the dots without oversimplifying your experience.In this episode, we sit down with gastroenterologist Dr. Zachary Spiritos to unpack mast cell activation syndrome (MCAS) and explore the connections between immune activation, the gut-brain axis, and symptoms that can affect nearly every system in the body. We discuss why patients are often dismissed, how stress and hormonal changes can amplify symptoms, and what a realistic, stepwise treatment approach looks like when the evidence base is still evolving.In this episode, we discuss:• What mast cells do and why MCAS can affect multiple organ systems • Why MCAS is often missed in siloed medical care and mislabeled as anxiety • Barrier dysfunction, environmental triggers, and intestinal permeability as a useful framework • Histamine as one mediator among many and why antihistamines are not a perfect treatment for all• Links between MCAS, IBS, visceral hypersensitivity, dysautonomia, and POTS • Hypermobility, pelvic floor dysfunction, and neck tension as common clinical clues • Treatment principles including start low and go slow, informed consent, and layered individualized plans • Dietary approaches patients commonly explore, including low-histamine, low-FODMAP, and gluten-free patterns • Hormonal influences across the menstrual cycle and during perimenopause• The role of sleep, nervous system regulation, and stress reduction in decreasing symptom reactivity If you've ever felt like your symptoms don't fit neatly into a single diagnosis, this episode will help you make sense of the bigger picture and explore what healing can look like when the gut, immune system, and nervous system are all part of the conversation. References:Ford AC, Staudacher HM, Talley NJ. Postprandial symptoms in disorders of gut-brain interaction and their potential as a treatment target. Gut. 2024;73(7):1199-1211. Published 2024 Jun 6. doi:10.1136/gutjnl-2023-331833Walker MM, Warwick A, Ung C, Talley NJ. The role of eosinophils and mast cells in intestinal functional disease. Curr Gastroenterol Rep. 2011;13(4):323-330. doi:10.1007/s11894-011-0197-5Pasricha PJ, Talley NJ. Functional Dyspepsia. N Engl J Med. 2026;394(2):166-176. doi:10.1056/NEJMcp2501860Find Dr. Spiritos on IG @drzacspiritosSo please like and subscribe and share the gut health podcast. Don't forget to subscribe, rate, and leave us a comment. Learn more about Kate and Dr. Riehl:Website: www.katescarlata.com and www.drriehl.comInstagram: @katescarlata @drriehl and @theguthealthpodcastOrder Kate and Dr. Riehl's book, Mind Your Gut: The Science-Based, Whole-body Guide to Living Well with IBS.  The information included in this podcast is not a substitute for professional medical advice, examination, diagnosis or treatment.  Always seek the advice of your physician or other qualified health care provider before starting any new treatment or making changes to existing treatment.

What if someone living at the center of pop culture and public scrutiny was quietly fighting the same toxic health battles you are, and nobody talked about it?Jenny McCarthy joins KB for a raw, unfiltered conversation about autoimmune disease, mold toxicity, vaccine injury, and the clean beauty lies hiding in your makeup bag. After battling mycotoxin poisoning, celiac disease, Hashimoto's, leaky gut, candida, and MCAS, Jenny became one of the most outspoken advocates for individualized medicine and non-toxic living, and she holds nothing back.She also opens up about her son Evan: the seizure, the cardiac arrest, the autism diagnosis following the MMR vaccine, and how healing his gut through functional medicine stopped his life-threatening seizures and changed everything she believed about health advocacy.You'll discover:The raw truth about mycotoxin and mold poisoningThe peptide stack Jenny is currently using, and why sourcing mattersWhy she created Formless BeautyWhat self-love actually looks like in practice Two non-negotiable toxic-free habits anyone can start todayThis is a masterclass in feminine resilience, radical self-advocacy, and what it truly means to live non-toxic, from the inside out. Jenny hasn't just talked about clean living. She has lived through the darkest version of what happens when your body is overwhelmed by toxins, and she came back fighting.If this episode moved you, share it with someone who needs to hear it, and subscribe so you never miss an episode!

You have been told it is just weight. Just diet. Just effort. For millions of women with lipedema, that is not just wrong. It is decades of unnecessary suffering. In this episode of Bendy Bodies, I sit down with Kasi Grosvenor and Jesse Cochrane from the Lipedema Foundation to pull back the curtain on one of the most misdiagnosed and misunderstood conditions in women's health. Kasi spent decades fainting, being dismissed, and searching for answers before finally finding clarity at the intersection of lipedema and hereditary alpha tryptasemia. Her story is not unusual. It is the norm for this patient population. Jesse brings the science. Lipedema is not obesity. It is not a lifestyle problem. It is a chronic medical condition involving disproportionate, painful, fibrotic adipose tissue that resists caloric restriction and exercise by design. Emerging research points to extracellular matrix dysfunction as a potential shared biological thread connecting lipedema to Ehlers-Danlos Syndromes (EDS), hypermobility, Postural Orthostatic Tachycardia Syndrome (POTS), and Mast Cell Activation Syndrome (MCAS). The overlap is not coincidental. It may be biological. We cover what clinicians and patients both need to understand: Why the absence of biomarkers has made diagnosis so difficult, and what the evolving definition of the disease actually means for patients seeking answers. Why lipedema tissue behaves differently from typical fat, and why standard weight loss advice not only fails but can cause harm. What conservative management actually looks like, including medical compression, pneumatic compression pumps, anti-inflammatory nutrition, and specialized manual therapies. The truth about lipedema removal surgery. This is not cosmetic liposuction. It is a medical intervention to remove diseased tissue, and its outcomes depend heavily on what comes before and after the procedure. If you have been dismissed, misdiagnosed, or told to try harder, this episode is for you. Takeaways: Lipedema is not obesity. The tissue is structurally and biologically different, and it does not respond to diet and exercise the way standard fat tissue does. Pain and tenderness in the affected tissue is a hallmark feature, not a coincidence. If you have EDS, HSD, POTS, or MCAS, lipedema may be part of your picture. The biological overlap is real and increasingly supported by research. A normal BMI does not rule out lipedema. Diagnosis is clinical, not based on weight. Lipedema removal surgery is a medical procedure. Calling it cosmetic liposuction misrepresents both the tissue and the intent. The absence of biomarkers does not mean the condition is not real. It means the research has not caught up yet. Want more Kasi Grosvenor & Jesse Cochrane? https://x.com/LipedemaFndn https://www.instagram.com/lipedema_fndn/ https://www.facebook.com/Lipedema/ https://www.youtube.com/channel/UCvpjYrsAUGB0-evCNqsSrGA https://www.lipedema.org/ Go AquaTru.com now for 20% off (your purifier) using promo code BENDY. Head to cozyearth.com and use my code BENDY for up to 30% off — but only for a limited time. This exclusive offer runs from May 18th through June 1st only, so don't wait. Want more Dr. Linda Bluestein, MD? Website: https://www.hypermobilitymd.com/ YouTube: https://www.youtube.com/@bendybodiespodcast Instagram: ⁠⁠⁠⁠https://www.instagram.com/hypermobilitymd/⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠https://www.facebook.com/BendyBodiesPodcast⁠⁠⁠⁠ X: ⁠⁠⁠⁠https://twitter.com/BluesteinLinda⁠⁠⁠⁠ LinkedIn: ⁠⁠⁠⁠https://www.linkedin.com/in/hypermobilitymd/⁠⁠⁠⁠ Newsletter: ⁠⁠⁠⁠https://hypermobilitymd.substack.com/ Shop my Amazon store ⁠⁠⁠ https://www.amazon.com/shop/hypermobilitymd Dr. Bluestein's Recommended Herbs, Supplements and Care Necessities: https://us.fullscript.com/welcome/hypermobilitymd/store-start Want to learn more about the UVA EDS Center? For Appointments and Questions: RUVAEDSCenter@uvahealth.org UVA EDS: https://www.uvahealth.com/healthy-practice/advancing-care-through-ehlers-danlos-clinic UVA EDS FAQ: https://www.uvahealth.com/support/eds/faq UVA Pediatric Integrative Medicine: https://childrens.uvahealth.com/specialties/integrative-health Thank YOU so much for tuning in. We hope you found this episode informative, inspiring, useful, validating, and enjoyable. Join us on the next episode for YOUR time to level up your knowledge about hypermobility disorders and the people who have them. Join YOUR Bendy Bodies community at ⁠⁠https://www.bendybodiespodcast.com/⁠⁠. YOUR bendy body is our highest priority!⁠⁠ Learn more about Human Content at ⁠⁠⁠http://www.human-content.com⁠⁠⁠ Podcast Advertising/Business Inquiries: ⁠⁠⁠sales@human-content.com⁠⁠⁠ Part of the Human Content Podcast Network FTC: This video is not sponsored. Links are commissionable, meaning I may earn commission from purchases made through links Learn more about your ad choices. Visit megaphone.fm/adchoices

You have been told it is just weight. Just diet. Just effort. For millions of women with lipedema, that is not just wrong. It is decades of unnecessary suffering. In this episode of Bendy Bodies, I sit down with Kasi Grosvenor and Jesse Cochrane from the Lipedema Foundation to pull back the curtain on one of the most misdiagnosed and misunderstood conditions in women's health. Kasi spent decades fainting, being dismissed, and searching for answers before finally finding clarity at the intersection of lipedema and hereditary alpha tryptasemia. Her story is not unusual. It is the norm for this patient population. Jesse brings the science. Lipedema is not obesity. It is not a lifestyle problem. It is a chronic medical condition involving disproportionate, painful, fibrotic adipose tissue that resists caloric restriction and exercise by design. Emerging research points to extracellular matrix dysfunction as a potential shared biological thread connecting lipedema to Ehlers-Danlos Syndromes (EDS), hypermobility, Postural Orthostatic Tachycardia Syndrome (POTS), and Mast Cell Activation Syndrome (MCAS). The overlap is not coincidental. It may be biological. We cover what clinicians and patients both need to understand: Why the absence of biomarkers has made diagnosis so difficult, and what the evolving definition of the disease actually means for patients seeking answers. Why lipedema tissue behaves differently from typical fat, and why standard weight loss advice not only fails but can cause harm. What conservative management actually looks like, including medical compression, pneumatic compression pumps, anti-inflammatory nutrition, and specialized manual therapies. The truth about lipedema removal surgery. This is not cosmetic liposuction. It is a medical intervention to remove diseased tissue, and its outcomes depend heavily on what comes before and after the procedure. If you have been dismissed, misdiagnosed, or told to try harder, this episode is for you. Takeaways: Lipedema is not obesity. The tissue is structurally and biologically different, and it does not respond to diet and exercise the way standard fat tissue does. Pain and tenderness in the affected tissue is a hallmark feature, not a coincidence. If you have EDS, HSD, POTS, or MCAS, lipedema may be part of your picture. The biological overlap is real and increasingly supported by research. A normal BMI does not rule out lipedema. Diagnosis is clinical, not based on weight. Lipedema removal surgery is a medical procedure. Calling it cosmetic liposuction misrepresents both the tissue and the intent. The absence of biomarkers does not mean the condition is not real. It means the research has not caught up yet. Want more Kasi Grosvenor & Jesse Cochrane? https://x.com/LipedemaFndn https://www.instagram.com/lipedema_fndn/ https://www.facebook.com/Lipedema/ https://www.youtube.com/channel/UCvpjYrsAUGB0-evCNqsSrGA https://www.lipedema.org/ Go AquaTru.com now for 20% off (your purifier) using promo code BENDY. Head to cozyearth.com and use my code BENDY for up to 30% off — but only for a limited time. This exclusive offer runs from May 18th through June 1st only, so don't wait. Want more Dr. Linda Bluestein, MD? Website: https://www.hypermobilitymd.com/ YouTube: https://www.youtube.com/@bendybodiespodcast Instagram: ⁠⁠⁠⁠https://www.instagram.com/hypermobilitymd/⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠https://www.facebook.com/BendyBodiesPodcast⁠⁠⁠⁠ X: ⁠⁠⁠⁠https://twitter.com/BluesteinLinda⁠⁠⁠⁠ LinkedIn: ⁠⁠⁠⁠https://www.linkedin.com/in/hypermobilitymd/⁠⁠⁠⁠ Newsletter: ⁠⁠⁠⁠https://hypermobilitymd.substack.com/ Shop my Amazon store ⁠⁠⁠ https://www.amazon.com/shop/hypermobilitymd Dr. Bluestein's Recommended Herbs, Supplements and Care Necessities: https://us.fullscript.com/welcome/hypermobilitymd/store-start Want to learn more about the UVA EDS Center? For Appointments and Questions: RUVAEDSCenter@uvahealth.org UVA EDS: https://www.uvahealth.com/healthy-practice/advancing-care-through-ehlers-danlos-clinic UVA EDS FAQ: https://www.uvahealth.com/support/eds/faq UVA Pediatric Integrative Medicine: https://childrens.uvahealth.com/specialties/integrative-health Thank YOU so much for tuning in. We hope you found this episode informative, inspiring, useful, validating, and enjoyable. Join us on the next episode for YOUR time to level up your knowledge about hypermobility disorders and the people who have them. Join YOUR Bendy Bodies community at ⁠⁠https://www.bendybodiespodcast.com/⁠⁠. YOUR bendy body is our highest priority!⁠⁠ Learn more about Human Content at ⁠⁠⁠http://www.human-content.com⁠⁠⁠ Podcast Advertising/Business Inquiries: ⁠⁠⁠sales@human-content.com⁠⁠⁠ Part of the Human Content Podcast Network FTC: This video is not sponsored. Links are commissionable, meaning I may earn commission from purchases made through links Learn more about your ad choices. Visit megaphone.fm/adchoices

On the Evolving Wellness podcast, host Sarah Kleiner interviews returning guest Steve about seasonal allergies, histamine intolerance, and MCAS, emphasizing that the root problem is often loss of immune tolerance driven by gut dysbiosis, leaky gut, and Th1/Th2 imbalance from factors like antibiotics, PPIs, stress, mold, and environmental changes. They contrast symptom tools—antihistamines that block histamine receptors and herbs like quercetin/ginger that stabilize mast cells—with approaches aimed at lowering IgE formation and retraining gut–immune “crosstalk.” Steve describes postbiotics and beta-glucans as “tolerization rehab,” highlighting his product HoloImmune (heat-killed strains) and butyrate (TriButyrin-X) for gut lining and mast cell support, plus DAO enzymes for dietary histamine. They discuss safety, dosing, avoiding live probiotics during flares, and examples including motion sickness, bug-bite welts, and a child's post-viral hives.— GUT HEALTH:  Healthy Gut Supplements- discount automatically applied: Holoimmune: https://healthygut.com/holoimmune-now/?rstr=811&coupon_code=Sarah15 Holozyme Link: https://healthygut.com/holozyme-now/?rstr=811&coupon_code=Sarah15 HCL Guard Link: https://healthygut.com/hcl-guard-now/?rstr=811&coupon_code=Sarah15 Tributyrin X: https://healthygut.com/tributyrin-x-now/?rstr=811&coupon_code=Sarah15 Magnesium: https://healthygut.com/magnesiumhp-now/?rstr=811&coupon_code=Sarah15 _________Sponsored By:→ VivaRays | This episode is sponsored by VivaRays - VivaRays Blue - code YOGI https://vivarays.com/→ Bon Charge | Go to https://boncharge.com/products/demi-red-light-device?rfsn=8108115.26608d & use code SARAHKLEINER for 15% off storewide._________Timestamp:00:00 Coming Up01:02 Podcast Intro Disclaimer02:15 Spring Allergies Setup05:05 Loss Of Tolerance08:02 Why Symptoms Worsen10:25 How Antihistamines Work11:59 Mast Cell Stabilizers14:20 Rewiring With Postbiotics16:20 Red Light Sponsor Break17:59 MCAS Pepcid Bridge22:11 Gut Healing Without Probiotics25:45 Blue Blockers Sponsor Break27:12 Mold And Individual Variance29:57 Antibiotics Farm Effect31:39 Dead Bugs Vs Probiotics32:40 Live vs Dead Probiotics33:25 Immune Software Updates35:28 Strawberry Hives Story36:40 Allergy Medicine Toolkit37:25 DAO Enzyme Explained40:05 Springtime Support Stack40:48 Root Causes and Triggers42:38 Immune Rehab and Tolerance45:56 How to Start Dosing49:11 Coaching Over AI51:47 Antihistamines and Acid Blockers53:56 How Long to Take It56:35 Leaky Gut and Butyrate57:39 Hidden Histamine Symptoms58:29 Motion Sickness and Bug Welts01:00:17 Wrap Up and Resources——— This video is not medical advice & as a supporter to you and your health journey - I encourage you to monitor your labs and work with a professional!________________________________________Get all my free guides and product recommendations to get started on your journey!https://www.sarahkleinerwellness.com/all-free-resourcesCheck out all my courses to understand how to improve your mitochondrial health & experience long lasting health! (Use code PODCAST to save 10%) -  https://www.sarahkleinerwellness.com/coursesMy free product guide with all product recommendations and discount codes:https://www.canva.com/design/DAF7mlgZpJI/xVyE4tiQFEWJmh_Xwx8Kbw/view?utm_content=DAF7mlgZpJIFree Webinar on Light & Health (includes free light bulb guide) - https://www.sarahkleinerwellness.com/mycircadianapp-free-webinarGet Early Access to Podcast Episodes & my Seasonal Food Course + UVB+Red Light Therapy course for free -  https://open.substack.com/pub/sarahkleinerwellness/p/uvbred-light-protocol?r=5eztl9&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

What happens when your labs are “normal” but your symptoms are very real?In this powerful conversation, rheumatologist Dr. Isabelle Amigues sits down with allergist/immunologist Dr. Kara Wada to discuss one of the biggest frustrations autoimmune patients face: being told that everything looks “fine” despite ongoing symptoms.Together, they explore the reality of seronegative autoimmune disease, MCAS (mast cell activation syndrome), Sjögren's syndrome, immune dysfunction, inflammation, and why many patients are falling through the cracks of traditional healthcare systems.This conversation dives into:• Why normal labs do NOT always mean you are healthy• The limitations of autoimmune testing• Seronegative rheumatoid arthritis & Sjögren's• MCAS and mast cell activation syndrome explained• The importance of listening to patients• Why autoimmune diseases are often missed• The difference between research criteria and real-life medicine• Direct care medicine and personalized patient care• Chronic inflammation, immune dysregulation & hidden illness• Why patients need doctors who truly listenIf you've ever been told “your labs are normal” while still struggling with symptoms, this episode is for you.

In this episode of the IRH Clinician's Corner, we're presenting a special panel discussion from our recent Clinical Success Showcase event in January. Host Kristin Whitaker is joined by a powerhouse panel of master practitioners as they break down what histamine intolerance really means, why symptoms like skin issues, gut problems, brain fog, and anxiety are showing up more frequently in practice, and how the world around us might be fueling this trend. You'll learn the spectrum of histamine-related disorders, the known drivers behind these conditions—from chronic infections and toxic exposures to hormonal swings and even trauma—and, most importantly, practical, foundational strategies to help calm symptoms, restore balance, and support your clients or yourself. In this interview, we discuss:   The critical role mast cells and histamine play in immune function, inflammation, and symptom development. How to recognize the often-overlooked symptom patterns associated with histamine intolerance and mast cell activation. Why these conditions are becoming increasingly common and the environmental and lifestyle factors that may be contributing. The powerful relationship between histamine, estrogen, and hormone-related symptom flares throughout a woman's cycle. The most common root causes driving histamine-related symptoms Practical tools for calming the histamine response, supporting recovery, and helping clients expand their diets with confidence. The Clinician's Corner is brought to you by the Institute of Restorative Health. Follow us: https://www.instagram.com/instituteofrestorativehealth/   This episode is brought to you by the Clinical Success Showcase, happening June 1–4 from the Institute of Restorative Health.  Join practitioners from across the industry for four free days of real clinical case studies, expert panels, and practical conversations designed to help you think more systematically and confidently in practice. From pediatric eczema and mood concerns to male hormones, complex chronic cases, and optimizing outcomes for clients on GLP-1 therapies, each session is built around real-world application you can actually use with clients. The Clinical Success Showcase is proudly brought to you by LeadCalculators, Evexia Diagnostics, MRT: A Superior Approach to Managing Diet-Induced Inflammation, and BetterBloodTest.com.  Register free and save your spot today. Timestamps:  00:00 Preview of histamine intolerance panel 09:22 Discussing oncology nutrition certification 14:17 Understanding symptom increase factors 20:25 Discussing mysterious symptoms and triggers 23:14 Understanding histamine intolerance 27:42 Balancing complexity and simplicity in health 33:28 Chronic inflammation and hormones discussion 40:06 Explaining the histamine bucket analogy 45:22 Managing food sensitivities and fear 54:18 Discussing antihistamine trial periods 59:02 Knowing when to refer clients 01:01:23 Advice for new health practitioners 01:10:05 Managing Histamine Intolerance Symptoms 01:14:01 Discussing mast cell stabilizers 01:17:47 Engaging with the panel discussion Speaker bios:  Ellen Lovelace, MPH, FNTP, MRHP is a Master Restorative Health Practitioner and faculty member at the Institute of Restorative Health who brings nearly 20 years of experience in public health and functional nutrition. Sara Fields, FNTP, MRHP is a Master Restorative Health Practitioner and faculty member at the Institute of Restorative Health who specializes in gut health, fertility, and helping clients uncover the root causes of chronic health concerns. Min Kim, NTP, MRHP is a Master Restorative Health Practitioner who helps clients uncover root causes, interpret complex health patterns, and create practical nutrition strategies that support long-term wellness. Keywords:  Clinician's Corner, functional health, histamine intolerance, mast cell activation syndrome, MCAS, mast cell disorders, root causes, gut health, autoimmune conditions, mental health, sleep issues, hormone fluctuations, perimenopause, menopause, estrogen dominance, chronic inflammation, mold exposure, long covid, chronic infections, GI MAP test, Dutch Test, MRT food sensitivity test, DAO enzymes, low histamine diet, antihistamines, H1 blockers, H2 blockers, nervous system support, dietary strategies, trauma and health, client intake forms Disclaimer: The views expressed in the IRH Clinician's Corner series are those of the individual speakers and interviewees, and do not necessarily reflect the views of the Institute of Restorative Health, LLC. The Institute of Restorative Health, LLC does not specifically endorse or approve of any of the information or opinions expressed in the IRH Clinician's Corner series. The information and opinions expressed in the IRH Clinician's Corner series are for educational purposes only and should not be construed as medical advice. If you have any medical concerns, please consult with a qualified healthcare professional. The Institute of Restorative Health, LLC is not liable for any damages or injuries that may result from the use of the information or opinions expressed in the IRH Clinician's Corner series. By viewing or listening to this information, you agree to hold the Institute of Restorative Health, LLC harmless from any and all claims, demands, and causes of action arising out of or in connection with your participation. Thank you for your understanding.  

New research suggests that low-dose peptide therapy may help calm histamine-driven inflammation and mast cell activation in people with stubborn symptoms like food reactions, brain fog, fatigue, flushing, itching, hives, bloating, and digestive distress. In this episode, Dr. Ruscio explains how the gut, histamine, and mast cells are connected, what the latest human research shows, and why this approach may help some patients who haven't fully responded to diets, supplements, or other natural therapies.  

Freu dich nicht zu spät und sei jeden Tag dankbar für deinen gesunden Körper, wenn du ihn hast

Why do your symptoms keep coming back… even when you're doing the "right" things? You clean up your diet. You take the supplements. You commit to the routine. You start feeling better. But the bloating comes back. The energy crashes return. The inflammation flares again. Or a completely different symptom shows up. And suddenly it feels like you're taking one step forward and two steps back. In this episode of The Health Made Simple Show, Dr. Bart explains why this pattern is so common (and why chronic symptoms usually require more than one quick fix). He breaks down what a "syndrome" really means, and why conditions like MCAS, leaky gut, IBS, metabolic syndrome, and chronic fatigue often involve multiple issues happening at the same time. In this episode, you'll learn: Why one supplement, medication, diet, or cleanse rarely solves chronic symptoms What your body may be trying to tell you when symptoms keep returning Why the order of healing matters just as much as the tools you use How stress, toxins, gut dysfunction, sleep, and lifestyle habits can all compound over time Why a personalized, root-cause strategy is often the missing link If you've been doing "all the right things" but still don't feel like yourself, this episode will help you start seeing the bigger picture.    

Up to 1 in 5 people may have this condition and never know it and the diagnoses they've been handed instead, from PCOS to IBS to chronic fatigue, may all be pointing at the same hidden cause. In this episode, I sit down with Dr. Tania Dempsey, Johns Hopkins-trained internist and one of the leading researchers on Mast Cell Activation Syndrome, who tells me that 100% of her PCOS patients test positive for MCAS, and walks me through why mast cells may be the most overlooked driver of chronic illness in modern medicine. If you've been told your symptoms are idiopathic, or that nothing's wrong even though everything feels wrong, this is the conversation that finally connects the dots. CLICK HERE TO BECOME GARY'S VIP!: ⁠https://bit.ly/4ai0Xwg⁠ Get Dr. Tania Dempsey's audio book, “Mast Cell Matters”: ⁠https://bit.ly/4drrnOf⁠  Listen to Dr. Tania Dempsey on all your favorite platforms! YouTube: ⁠https://bit.ly/4dcVlqs⁠  Spotify: ⁠https://bit.ly/4dsS9G2⁠  Apple Podcasts: ⁠https://bit.ly/3PjGhy6⁠  Connect with Tania Dempsey Website: ⁠https://bit.ly/4dKXgTe⁠  YouTube: ⁠https://bit.ly/4dcVlqs⁠   Instagram: ⁠https://bit.ly/4f7kHrd⁠  Facebook: ⁠https://bit.ly/3R6sOdz⁠   LinkedIn: ⁠https://bit.ly/4ddPilv⁠   Thank you to our partners A-GAME: “ULTIMATE15” FOR 15% OFF: http://bit.ly/4kek1ij AION: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4h6KHAD AIRES: "ULTIMATE20 " FOR 20% OFF: https://bit.ly/4a3Duze BAJA GOLD: "ULTIMATE10" FOR 10% OFF: https://bit.ly/3WSBqUa BODYHEALTH: “ULTIMATE20” FOR 20% OFF: http://bit.ly/4e5IjsV COLD LIFE: THE ULTIMATE HUMAN PLUNGE: https://bit.ly/4eULUKp CYMBIOTIKA: "ULTIMATE10" FOR 10% OFF: https://bit.ly/4tjyluP GENETIC METHYLATION TEST (UK ONLY): https://bit.ly/48QJJrk GENETIC TEST (USA ONLY): ⁠https://bit.ly/3Yg1Uk9 GOPUFF: GET YOUR FAVORITE SNACK!: https://bit.ly/4obIFDC H2TAB: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4hMNdgg HEALF: 10% OFF YOUR ORDER: https://bit.ly/41HJg6S PEPTUAL: “TUH10” FOR 10% OFF: https://bit.ly/4mKxgcn SNOOZE: LET'S GET TO SLEEP!: https://bit.ly/4pt1T6V WHOOP: JOIN & GET 1 FREE MONTH!: https://bit.ly/3VQ0nzW Watch  the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST: YouTube: ⁠https://bit.ly/3RPQYX8⁠ Podcasts: ⁠https://bit.ly/3RQftU0⁠ Connect with Gary Brecka Instagram: ⁠https://bit.ly/3RPpnFs⁠ TikTok: ⁠https://bit.ly/4coJ8fo⁠ X: ⁠https://bit.ly/3Opc8tf⁠ Facebook: ⁠https://bit.ly/464VA1H⁠ LinkedIn: ⁠https://bit.ly/4hH7Ri2⁠ Website: ⁠https://bit.ly/4eLDbdU⁠ Merch: ⁠https://bit.ly/4aBpOM1⁠ Newsletter: ⁠https://bit.ly/47ejrws⁠ Ask Gary: ⁠https://bit.ly/3PEAJuG⁠ Timestamps 00:00 ​Intro of Show 03:52 - The biology of mast cells 05:34 - Inflammation, allergies, and dystrophisms 09:00 - Connective tissue, POTS, and Ehlers-Danlos 09:40 - Gary's daughter and the toxic load 13:24 - Symptoms from head to toe 18:20 - GLP-1 receptors on mast cells 23:47 - Identifying the upstream triggers 27:38 - Treating viral and bacterial loads 31:35 - The herpes virus family and reactivation 35:47 - SOT therapy and targeted mRNA 38:17 - The immunofatigue theory of aging 45:03 - Therapeutic plasma exchange and detox 58:09 - Gut dysbiosis and the microbiome 1:00:58 - Cryptosporidium and parasite testing 1:06:30 - Hope and the path forward Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions. Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation.  Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered.  Learn more about your ad choices. Visit megaphone.fm/adchoices

“It's very accessible to understand what's happening in the body by looking at the self and how one feels. You just have to learn that language.”So much of cycle tracking is built around prediction. Apps guesstimate ovulation days, wearables collect temperature and sleep data, and algorithms try to tell women about their individual cycles based on averages and patterns. But our bodies don't work based on averages. They shift in response to stress, illness, travel, sleep, inflammation, recovery, and the realities of everyday life. And for many women, relying on cycle tracking technology ends up creating more disconnection from their body instead of more understanding.The conversation around cycle tracking needs to focus on the specific person living the cycle. We need to move beyond collecting data and actually learn how to interpret symptoms, emotional shifts, pain patterns, cervical fluid changes, energy fluctuations, and nervous system responses in context. That kind of awareness can completely change the way practitioners approach conditions like endometriosis, PMDD, chronic pelvic pain, infertility, PCOS, perimenopause, and even mental health care because patients are empowered and patterns start becoming more visible in a clinically useful way.In this episode, I'm joined by Laura Federico and Morgan Miller, midwife and co-creators of The Cycle Book, a thoughtful pen-and-paper tracking and education tool designed to help people better understand their hormonal and physical patterns over time. We discuss the limitations of cycle-tracking apps, data privacy concerns, why algorithms often misidentify ovulation and cycle phases, how tracking physical and emotional biomarkers can support earlier recognition of many conditions, the relationship between cycle tracking and mental health care, collaborative treatment planning, and more.Enjoy the episode, and let's innovate and integrate together!---Learn more or watch the video version of this conversation at https://integrativewomenshealthinstitute.com/cycle-tracking-for-mental-health-mcas-endometriosis-pcos-pmdd-and-more/.Connect with me and access our entire platform at IntegrativeWomensHealthInstitute.com (https://integrativewomenshealthinstitute.com/).Find and follow us @integrativewomenshealth on YouTube (https://www.youtube.com/@integrativewomenshealth) and Instagram (https://www.instagram.com/integrativewomenshealth/).

Hast du auf Social Media schon kritische Posts über L-Glutamin gesehen und bist jetzt verunsichert? In dieser Folge nehme ich sieben häufige Vorwürfe gegen die Aminosäure auseinander und ordne sie wissenschaftlich ein. Du erfährst, was an den Warnungen dran ist und wann Vorsicht wirklich geboten ist. L-Glutamin ist eine der am häufigsten vorkommenden Aminosäuren im Körper und spielt eine wichtige Rolle für die Darmschleimhaut, das Immunsystem und die Muskulatur. Aber ist es auch für jeden geeignet? Ich spreche über Histaminintoleranz, MCAS, Leberfunktion und die Rolle von Glutamat im Nervensystem. Ausserdem bekommst du praktische Dosierungsempfehlungen und erfährst, warum wir unser L-Glutamin als Pulver anbieten. Das erfährst du Was L-Glutamin im Körper macht und warum es für den Darm so wichtig ist Welche der 7 Social-Media-Vorwürfe wissenschaftlich haltbar sind (und welche nicht) Wann du bei Histaminintoleranz, MCAS oder Lebererkrankungen vorsichtig sein solltest Wie du L-Glutamin richtig dosierst und anwendest Warum Pulver mehr Kontrolle gibt als Kapseln   Zeitstempel 00:00 Einführung in L-Glutamin 02:38 Die Funktionen von L-Glutamin im Körper 05:54 Kritikpunkte und Bedenken zu L-Glutamin 08:46 Die sieben Vorwürfe gegen L-Glutamin 20:33 Praktische Anwendung und Dosierung von L-Glutamin   LINKS Alle Folgennotizen findest du auf https://arktisbiopoharma.ch/podcast/l-glutamin-darmgesundheit-7-bedenken-julia-gruber-dg350 L-Glutamin Pulver im Shop: https://arktisbiopharma.ch/products/l-glutamin-glutamin-500g Als Podcasthörer:in bekommst du von uns einen Rabatt auf unsere Produkte. Und zwar 15% Rabatt auf deinen ersten Einkauf (1-mal anwendbar, nur auf nicht bereits rabattierte Produkte). Der Gutscheincode ist in beiden Arktis BioPharma Shops in der SCHWEIZ und in DEUTSCHLAND gültig. Gib hierfür den Gutscheincode podcast15 ein, bevor du deine Bestellung abschliesst. Arktis BioPharma SCHWEIZ Arktis BioPharma DEUTSCHLAND Abonniere den Darmglück-Podcast in deiner Lieblings-Podcastapp (Apple Podcasts, Spotify, Deezer, Google Podcasts etc.), indem du "Darmglück" in die Suche eingibst.  

In this Ask Me Anything episode, Dr. Will Cole and his team answer listener questions on canker sores (and when they're a sign of something more), MCAS and mold toxicity in a school classroom, autoimmune thrombocytopenia in a 23-year-old naturopathic medical student with Hashimoto's and PCOS, and whether cast iron skillet seasoning is actually a health concern. They also cover the EMF-mold connection most people haven't heard of, blood-building foods and peptides for autoimmune platelet issues, and the right oils to season with based on smoking point. Plus: the team's Sip of the Summer picks and Dr. Cole's mason jar mocktail recipe. For all links mentioned in this episode, visit www.drwillcole.com/podcast.Please note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.Sponsors:Find out more at apple.com/health. This message was brought to you by Apple and AT&T. Apple Watch is not a medical device and should not be used as a substitute for professional medical advice. Head to MANUKORA.com/WILLCOLE to save up to 31% plus $25 worth of free gift swith the Starter Kit, which comes with an MGO 850+ Manuka Honey jar, 5 honey travel sticks, a wooden spoon, and a guidebook.Refresh your wardrobe with Quince. Go to Quince.com/willcole for free shipping and 365-day returns. Now available in Canada, too.Text ABW to 64000 to get 20% off all IQBAR products, plus FREE shipping. Message and data rates may apply.To learn more and get 20% off your order, visit ActiveSkinRepair.com and use code: WILLCOLE . You can also find Active Skin Repair on Amazon and at your local CVS.Produced by Dear Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

When Doctors Dont Have Answers: Self Advocacy with Jamie Lee What do you do when your body knows something is wrong but every test says you're "fine"? In this episode of Rebel Mama Pod, host Sarah Castañeda sits down with career coach Jamie Lee for a deeply personal conversation about neurodivergence, women's health, burnout, and learning to trust yourself when conventional systems fail you. Jamie shares her experience navigating unexplained symptoms, brain fog, anxiety, hormonal shifts, mast cell activation syndrome (MCAS), and the frustrating reality of being dismissed by traditional healthcare providers. Together, they unpack the connection between ADHD, chronic stress, inflammation, and self advocacy and why so many women are forced to become their own researchers just to get answers. This episode is a powerful reminder that self advocacy starts with trusting your own experience.

When Billie Eilish recently stated that you cannot claim to love all animals while simultaneously eating them, the internet imploded. From accusations of "vegan privilege" to debates over Indigenous rights and MCAS-friendly diets, the backlash was a masterclass in cognitive dissonance. This mini solo episode discusses: The Contradiction: Why Billie's statement triggered so many people and the psychology of why we "love" some animals but consume others. The Health Debunk: Addressing the claims that plant proteins are "hard to digest" or incompatible with Mast Cell Activation Syndrome (MCAS). The Science of "Fake" Meats: A 2024 meta-analysis shows that plant-based meat alternatives actually lead to better cardiometabolic outcomes (lower LDL, cholesterol, and weight) when replacing animal meat. The "Anti-Indigenous" Shield: Why using Indigenous survival as an excuse to buy factory-farmed meat is a form of tokenism that erases Indigenous vegans and those following a plant-based diet (including my own Métis family).  The "Vegan Police": My take on the internal community backlash regarding Billie riding horses and why we need to prioritize progress over perfection. Mentioned in this episode: Quote by @hiilanilily on Indigenous sovereignty and veganism. Cardiometabolic health meta-analysis on plant-based meat alternatives. Previous episode: Métis and Plant-Based with my Mother. Work With Me If you want to transition to a plant-based lifestyle but feel overwhelmed by nutrition science, histamines, or meal planning, let's chat! I offer private consultations to help you thrive with personalized, evidence-based guidance.

May and Tim revisit her long COVID journey with a real progress update. After exponentially climbing spike protein antibody levels (12,000+ on LabCorp's quantitative test), autoimmune symptoms, and MCAS flares, May has finally turned a corner — and she walks listeners through what's working and why. Topics covered in this episode: Why the LabCorp quantitative spike antibody test (~$69) is more useful than Quest, which caps out at 2,500 What “normal” post-infection or post-vaccination antibody levels should look like vs. climbing pathological levels Why differentiating between vaccine-induced and infection-induced spike may matter less now, given widespread re-exposure and shedding The autoimmune and MCAS face of spikeopathy that doesn't get enough press compared to cardiorespiratory and clotting presentations The peptide protocol making the biggest difference for May, including dosing approach and cycling considerations How AI tools can help schedule complex supplement and peptide stacks Why May is layering insights from Peter McCullough (nattokinase), Tina Peers (NAC), Sabine Hazan (microbiome), and Tyler Panzner (genetics) rather than chasing one protocol Warning signs to watch for when evaluating influencers and “miracle cure” claims (nicotine patches, single-fix narratives) Why Tim believes post-COVID spikeopathy will be a larger long-term public health issue than the acute pandemic itself How to find a clinician who looks at the whole picture (genetics, epigenetics, microbiome, baseline labs) If you've been told “it can't be COVID” or you're chasing weird, unexplained symptoms that don't add up, this episode is for you. Links & Resources McCullough Foundation: https://www.mcculloughfnd.org/ Email the show: doc@bsfreemd.com  Previous BS Free MD episodes with Dr. Peter McCullough on spike protein and long COVID Previous BS Free MD episode with Dr. Tyler Panzner on genetics and epigenetics Disclaimer The information shared on BS Free MD is for educational and informational purposes only and does not constitute medical advice. Listening to this episode does not create a doctor-patient relationship. Every person's health situation is unique — what worked for May may not be appropriate for you. Always consult a qualified healthcare provider before starting, stopping, or changing any treatment, supplement, peptide, or medication. The opinions expressed are those of the hosts and guests and do not reflect the views of any affiliated organization.

Send Vanessa a Text MessageSupport Vanessa and Intentionally Well:Support the Intentionally Well PodcastIWP Recommended ProductsWhat happens when the experience of chronic illness itself becomes traumatic?In today's episode, we explore the intersection of chronic illness, health trauma, the nervous system, and the brain-body connection. This conversation goes beyond root causes and diagnoses to examine what living in survival mode for long periods of time can do to the body, mind, and healing process over time.Dr. Krista Morton and I discuss how chronic illness can shape the nervous system, reinforce fear patterns, impact emotional safety, and create physiological adaptations that many people living with complex illness know all too well. We also talk about the nuanced relationship between real physical illness and nervous system involvement—and why acknowledging the brain's role in healing is not the same as dismissing physiological dysfunction.This was a deeply thoughtful conversation that weaves together physiology, trauma, emotional health, nervous system regulation, and faith in a grounded and compassionate way.Dr. Krista Morton, D.Sc., MA, INHC is an integrative medicine practitioner and founder of SomaSonder Wellness, where she works with individuals navigating complex chronic illness through a whole-body, root-cause approach that honors both physiology and lived experience. Her work focuses on conditions including mold illness, Lyme disease, MCAS, CIRS, autoimmune conditions, and nervous system dysregulation.In this episode, we discuss: Health trauma and the long-term impact of chronic illness  How the brain and nervous system adapt to prolonged stress and illness  Chronic illness as a survival state  Fear, hypervigilance, and symptom amplification  Complex PTSD and the nervous system  Brain retraining and neural pathways  The relationship between physiology and emotional health  Mold illness, Lyme disease, MCAS, and chronic inflammatory conditions  Root-cause healing and whole-body approaches  The role of faith, resilience, and emotional safety in healingConnect with Dr. Krista Morton:Dr. Krista's WebsiteFollow Dr. Krista on InstagramBooks Referenced:You Were Never BrokenHealing the Shame That Binds YouConnect with Vanessa and the podcast: IWP Website: Intentionally Well PodcastPodcast on InstagramVanessa on InstagramPodcast on YouTubePodcast on TikTokPodcast on XEmail: intentionallywellpodcast@gmail.comSupport the showThis episode is for informational purposes only. Please consult a trusted health practitioner for individual concerns.

In this episode, Ash and Dusty discuss the important topic of when worsening ADHD symptoms may actually be caused or worsened by other physiological or medical conditions. They explore how hormonal changes related to PMS, PMDD, perimenopause, and menopause can significantly impact cognition, mood, and executive function. Dusty shares her personal experience with PMDD and how medication has been life-changing in managing symptoms that overlap with ADHD but require different treatment approaches. They also highlight other health issues such as anemia, mast cell activation syndrome (MCAS), hypermobility disorders like Ehlers-Danlos, TMJ, migraines, and sleep disruptions that can mimic or exacerbate ADHD symptoms. The hosts emphasize the importance of recognizing these co-occurring or separate conditions and how ADHD coaching can support managing them by focusing on follow-through, executive functioning, and problem-solving rather than "coaching out" chronic illness itself. Ash and Dusty encourage listeners to advocate for themselves with healthcare providers, get regular checkups, and explore potential underlying causes when symptoms suddenly worsen. They also caution against dismissing new or worsening symptoms as just ADHD and stress the value of integrated care between medical treatment and coaching to improve overall functioning and quality of life. Episode links + resources: Join the Community | Become a Patron Our Process: Understand, Own, Translate. About Asher and Dusty For more of the Translating ADHD podcast: Episode Transcripts: visit TranslatingADHD.com and click on the episode Follow us on Twitter: @TranslatingADHD Visit the Website: TranslatingADHD.com

Listen and subscribe to Money Making Conversations on iHeartRadio, Apple Podcasts, Spotify, www.moneymakingconversations.com/subscribe/ or wherever you listen to podcasts. New Money Making Conversations episodes drop daily. I want to alert you, so you don’t miss out on expert analysis and insider perspectives from my guests who provide tips that can help you uplift the community, improve your financial planning, motivation, or advice on how to be a successful entrepreneur. Keep winning! Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Sahra S. Halpern. Interview Purpose The purpose of this interview is to educate small business owners—especially entrepreneurs of color—about equitable access to capital, alternative lending pathways, and how to become “capital ready.” Sahra Halpern, President and CEO of the Business Consortium Fund (BCF), explains how mission‑driven lending fills the gap left by traditional banks and helps small businesses survive, grow, and ultimately graduate into mainstream financing. The conversation also aims to demystify lending, reduce fear around capital, and encourage entrepreneurs to build trusted financial relationships before entering moments of crisis. Core Themes Discussed 1. Why Small Businesses Are Turned Down by Banks Halpern explains that many small businesses are rejected by banks not because they lack potential, but because banks operate under strict underwriting and regulatory requirements. These systems often fail to account for resilience, experience, contracts, and future growth. BCF exists to serve as a bridge—supporting businesses where banks cannot and preparing them to eventually return as qualified borrowers. 2. Capital Curious vs. Capital Ready A key distinction introduced in the interview is the difference between businesses that are “capital curious” and those that are “capital ready.” Many entrepreneurs know they need funding but lack: Financial organization Clear projections Proper documentation A capital strategy BCF provides technical assistance to help businesses prepare for financing instead of setting them up to fail. 3. Mission‑Driven Lending and Community Impact Halpern frames lending as an ecosystem, not a transaction. When small businesses succeed: Business owners gain stability Employees gain jobs Communities grow stronger Large corporations benefit from more diverse and capable supply chains BCF focuses on long‑term economic impact, not short‑term profit. 4. CDFIs vs. SBA Loans The interview draws a clear distinction between Community Development Financial Institutions (CDFIs) like BCF and government entities such as the SBA. Key differences highlighted: SBA programs shift based on political administrations SBA underwriting has tightened in recent years CDFIs are nonprofit, mission‑aligned, and relationship‑driven CDFIs look at the whole entrepreneur, not just credit scores 5. The Danger of Merchant Cash Advance Loans Halpern strongly warns against Merchant Cash Advance (MCA) loans, which are often marketed as fast solutions but carry extremely high interest rates and long‑term consequences. She explains that: MCAs disqualify borrowers from future SBA refinancing They often trap business owners in cycles of expensive debt CDFIs like BCF can help refinance and escape these loans A real‑world case study (The Cut Buddy / Shark Tank entrepreneur) illustrates how BCF helped refinance over $1M in predatory debt and save a growing business. 6. Relationships Matter More Than Transactions Both Halpern and McDonald emphasize the importance of building lender relationships early, not only when cash flow is tight. BCF underwrites the entire business and the entrepreneur, rather than seizing control of a contract or revenue stream, as some factoring companies do. Power comes from having options—and informed decision‑making. Key Takeaways Banking rejection is not the end of the road Small businesses must prepare themselves to be capital ready CDFIs serve as critical bridges between entrepreneurs and traditional banks Fast money often leads to expensive, dangerous debt Merchant cash advances should be avoided whenever possible Mission‑driven lenders look at the whole entrepreneur, not just numbers Strong lender relationships protect businesses during uncertainty Capital should empower growth—not take control of your company Notable Quotes “Just because a bank says no doesn’t mean that’s the end of your road.” “We’re not just looking at your credit score—we’re looking at you as a whole entrepreneur.” “Capital readiness is not about desperation; it’s about preparation.” “If you’re sitting on a merchant cash advance loan right now, you are not stuck.” “Nothing makes me happier than seeing clients realize their dreams and grow into multimillion‑dollar businesses.” “You should talk to multiple lenders—but you should always understand the real cost of the money.” Conclusion Sahra Halpern’s interview serves as a practical roadmap and a cautionary lesson for small business owners navigating today’s uncertain economic landscape. It reinforces that access to capital is about strategy, education, and relationships, not just approval or rejection. The conversation encourages entrepreneurs to reclaim power, avoid predatory financing, and partner with institutions that are committed to their long‑term success and community impact. #SHMS #BEST #STRAWSee omnystudio.com/listener for privacy information.

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In this "MythBusters" edition of the Bendy Bodies Podcast, Dr. Linda Bluestein and recurring co-host Dr. Dacre Knight tackle the persistent misconceptions surrounding Ehlers-Danlos syndromes (EDS), hypermobility spectrum disorders (HSD), and their frequent companions, Postural Orthostatic Tachycardia Syndrome (POTS) and Mast Cell Activation Syndrome (MCAS). Dr. Knight, Medical Director of the UVA Health EDS and Hypermobility Disorder Center, shares why hypermobile EDS (hEDS) is a serious condition even when not life-threatening, and why a negative genetic test doesn't rule out a diagnosis. The conversation dives deep into the "invisible" impact of these disorders on long-term disability and work ability, while offering hope through a better understanding of pain processing and nociplastic pain. From debunking the idea that POTS is merely deconditioning to navigating the controversial waters of MCAS, this episode empowers patients and clinicians with the knowledge needed to look past the surface and recognize the systemic reality of bendy bodies. Takeaways: EDS Severity: Hypermobile EDS and HSD are serious, chronic conditions that cause multi-system impairment and long-term disability, regardless of whether they are immediately life-threatening. Genetic Testing Limits: Current genetic testing cannot rule out hEDS or HSD because their specific genetic markers remain unknown; diagnosis still relies on clinical history and physical assessment. POTS is Systemic: POTS is far more than simple deconditioning or a cardiac issue; it is a neurologic dysfunction of the autonomic nervous system that impacts everything from heart rate to temperature regulation. The MCAS Spectrum: While MCAS criteria are still evolving and controversial, focusing on clinical patterns and safe treatment responses can improve quality of life even when lab tests (e.g., tryptase) are negative. Pain vs. Damage: Pain is a complex, bidirectional experience; patients can experience significant pain without visible structural damage due to central sensitization and dysfunctional pain signaling. Want to learn more about the UVA EDS Center? Go AquaTru.com now for 20% off (your purifier) using promo code BENDY. For Appointments and Questions: RUVAEDSCenter@uvahealth.org UVA EDS: https://www.uvahealth.com/healthy-practice/advancing-care-through-ehlers-danlos-clinic UVA EDS FAQ: https://www.uvahealth.com/support/eds/faq UVA Pediatric Integrative Medicine: https://childrens.uvahealth.com/specialties/integrative-health Want more Dr. Linda Bluestein, MD? Website: https://www.hypermobilitymd.com/ YouTube: https://www.youtube.com/@bendybodiespodcast Instagram: ⁠⁠⁠⁠https://www.instagram.com/hypermobilitymd/⁠⁠⁠⁠ Facebook: ⁠⁠⁠⁠https://www.facebook.com/BendyBodiesPodcast⁠⁠⁠⁠ X: ⁠⁠⁠⁠https://twitter.com/BluesteinLinda⁠⁠⁠⁠ LinkedIn: ⁠⁠⁠⁠https://www.linkedin.com/in/hypermobilitymd/⁠⁠⁠⁠ Newsletter: ⁠⁠⁠⁠https://hypermobilitymd.substack.com/ Shop my Amazon store ⁠⁠⁠ https://www.amazon.com/shop/hypermobilitymd Dr. Bluestein's Recommended Herbs, Supplements and Care Necessities: https://us.fullscript.com/welcome/hypermobilitymd/store-start Thank YOU so much for tuning in. We hope you found this episode informative, inspiring, useful, validating, and enjoyable. Join us on the next episode for YOUR time to level up your knowledge about hypermobility disorders and the people who have them. Join YOUR Bendy Bodies community at ⁠⁠https://www.bendybodiespodcast.com/⁠⁠. YOUR bendy body is our highest priority!⁠⁠ Learn more about Human Content at ⁠⁠⁠http://www.human-content.com⁠⁠⁠ Podcast Advertising/Business Inquiries: ⁠⁠⁠sales@human-content.com⁠⁠⁠ Part of the Human Content Podcast Network FTC: This video is not sponsored. Links are commissionable, meaning I may earn commission from purchases made through links Learn more about your ad choices. Visit megaphone.fm/adchoices

Send us Fan MailAlex Marie Freed was a healthy mom of three when she suddenly began experiencing daily migraines, vomiting spells, panic attacks, dizziness, severe anxiety, food reactions, and debilitating fatigue.Doctors blamed pregnancy, stress, and anxiety. But what no one connected was that her symptoms began shortly after moving into a fixer-upper home with a history of flooding.In this episode of Never Been Sicker, Michael Rubino sits down with integrative health practitioner Alex Marie Freed to discuss her journey through mold illness, Lyme, MCAS, miscarriage, medical dismissal, and the long road back to health.Alex shares how her family was impacted, what finally helped her connect the dots, why remediation mistakes can make things worse, and how she now helps women and children dealing with complex chronic illness.This conversation is a powerful reminder that healing is possible, but the root cause has to be addressed.Timestamps00:00 Intro00:28 Symptoms begin01:21 Moving into the fixer-upper01:55 Mold wasn't on her radar03:08 Migraines, panic attacks & anxiety04:27 Connecting the dots05:29 The call that changed everything06:41 Turning pain into purpose06:54 Miscarriage, mold & infertility08:20 Fertility and toxic load10:45 Severe illness and survival mode12:16 Flooding and worsening symptoms12:57 Why the remediation failed14:20 Why kids are more vulnerable16:16 Why we've never been sicker17:18 The biggest lie in chronic illness18:33 Quick fixes vs root causes21:03 Shifting the healing mindset22:27 Being dismissed by doctors24:18 Mold, Lyme & MCAS connection26:08 Terrain-based healing explained27:39 Lyme disease controversies29:48 Life after healing32:40 The turning point in recovery36:00 Daily healing rituals38:06 Her healing program40:52 Message for those struggling42:05 Where to find Alex-----------------------------------------------------------------------------------------------Follow Alex:

What if chronic illness was a path towards healing on levels greater than just physical? In this episode of Metabolic Matters, host Christina Mason sits down with Alekha Akkappedi and her longtime best friend, Emily Sullivan, for a powerful, multi-dimensional healing journey. At just 22 years old, pre-med student Alekha's life changed overnight. What began as a simple infection quickly spiraled into a complex web of chronic conditions: POTS, mast cell activation, PCOS, GERD, and connective tissue disease. Left bedridden, her science trained mind begins seeking answers. As she begins to experience healing in modalities outside of her allopathic education, she finds herself asking more questions and embarks on an unexpected career path. Alekha navigates years of uncertainty, traveling on paths that blend science, circadian biology, nutrition, and spiritual practices. Emily shares what it was like to watch her best friend's struggles and triumphs. Her perspective offers insight on the power of friendship and how watching another make healing choices vicariously heals those in close proximity. Alekha and Emily both experience healing as cyclical on many levels. Both agree that HOPE is one of the greatest healers. What unfolds for these two young sages is not just a story of physical recovery but transformation that is intangible, emotional and physical.After almost a decade of research and healing work, Alekha created the ALI Protocol, a comprehensive approach for those dealing with POTS, MCAS and long covid that integrates biology, psychology and energetic practices.

Why Your Child Reacts to Everything: Histamine Intolerance vs MCAS in KidsThis week on the Natural Super Kids Podcast, we're unpacking one of the more confusing and complex allergy-related pictures we see in kids — when symptoms don't follow a clear pattern, allergy testing comes back normal, but your child is still clearly reacting to something.If your child seems to react to multiple foods, heat, stress, exercise, strong smells, or seemingly random environmental triggers, this episode will help you better understand what may be going on beneath the surface. We're talking about histamine intolerance, mast cell activation syndrome (MCAS), and mast cell dysregulation — and why these issues are often missed or misunderstood.In this episode, we explore:What histamine intolerance actually is, and why it is about poor histamine breakdown, not just eating high histamine foodsThe difference between histamine intolerance, mast cell activation syndrome, and mast cell dysregulation — and why symptoms can look so messy and unpredictableWhy standard allergy testing often misses these issues, even when your child is clearly reactingHow a more holistic approach focused on gut health, immune regulation, and inflammation can help calm the bigger picture

In this episode of Resiliency Radio with Dr. Jill, Dr. Jill Carnahan explores the complex intersection of chronic illness, environmental toxins, and the mind-body-spirit connection with Dr. Kelly McCann. Dr. McCann shares her personal journey through mold illness, Lyme disease, and Mast Cell Activation Syndrome (MCAS), revealing how environmental exposures and unresolved emotional stressors can combine to create chronic, difficult-to-treat conditions. Together, they discuss how modern toxic load—from mold and chemicals to microplastics—affects the body, and why healing requires more than just physical interventions. This episode highlights the importance of addressing nervous system regulation, trauma, and emotional health alongside environmental detoxification. This conversation offers a powerful new perspective on chronic illness as not just a disease—but a signal for deeper healing and transformation.

Listen and subscribe to Money Making Conversations on iHeartRadio, Apple Podcasts, Spotify, www.moneymakingconversations.com/subscribe/ or wherever you listen to podcasts. New Money Making Conversations episodes drop daily. I want to alert you, so you don’t miss out on expert analysis and insider perspectives from my guests who provide tips that can help you uplift the community, improve your financial planning, motivation, or advice on how to be a successful entrepreneur. Keep winning! Two-time Emmy and Three-time NAACP Image Award-winning, television Executive Producer Rushion McDonald interviewed Sahra S. Halpern. Interview Purpose The purpose of this interview is to educate small business owners—especially entrepreneurs of color—about equitable access to capital, alternative lending pathways, and how to become “capital ready.” Sahra Halpern, President and CEO of the Business Consortium Fund (BCF), explains how mission‑driven lending fills the gap left by traditional banks and helps small businesses survive, grow, and ultimately graduate into mainstream financing. The conversation also aims to demystify lending, reduce fear around capital, and encourage entrepreneurs to build trusted financial relationships before entering moments of crisis. Core Themes Discussed 1. Why Small Businesses Are Turned Down by Banks Halpern explains that many small businesses are rejected by banks not because they lack potential, but because banks operate under strict underwriting and regulatory requirements. These systems often fail to account for resilience, experience, contracts, and future growth. BCF exists to serve as a bridge—supporting businesses where banks cannot and preparing them to eventually return as qualified borrowers. 2. Capital Curious vs. Capital Ready A key distinction introduced in the interview is the difference between businesses that are “capital curious” and those that are “capital ready.” Many entrepreneurs know they need funding but lack: Financial organization Clear projections Proper documentation A capital strategy BCF provides technical assistance to help businesses prepare for financing instead of setting them up to fail. 3. Mission‑Driven Lending and Community Impact Halpern frames lending as an ecosystem, not a transaction. When small businesses succeed: Business owners gain stability Employees gain jobs Communities grow stronger Large corporations benefit from more diverse and capable supply chains BCF focuses on long‑term economic impact, not short‑term profit. 4. CDFIs vs. SBA Loans The interview draws a clear distinction between Community Development Financial Institutions (CDFIs) like BCF and government entities such as the SBA. Key differences highlighted: SBA programs shift based on political administrations SBA underwriting has tightened in recent years CDFIs are nonprofit, mission‑aligned, and relationship‑driven CDFIs look at the whole entrepreneur, not just credit scores 5. The Danger of Merchant Cash Advance Loans Halpern strongly warns against Merchant Cash Advance (MCA) loans, which are often marketed as fast solutions but carry extremely high interest rates and long‑term consequences. She explains that: MCAs disqualify borrowers from future SBA refinancing They often trap business owners in cycles of expensive debt CDFIs like BCF can help refinance and escape these loans A real‑world case study (The Cut Buddy / Shark Tank entrepreneur) illustrates how BCF helped refinance over $1M in predatory debt and save a growing business. 6. Relationships Matter More Than Transactions Both Halpern and McDonald emphasize the importance of building lender relationships early, not only when cash flow is tight. BCF underwrites the entire business and the entrepreneur, rather than seizing control of a contract or revenue stream, as some factoring companies do. Power comes from having options—and informed decision‑making. Key Takeaways Banking rejection is not the end of the road Small businesses must prepare themselves to be capital ready CDFIs serve as critical bridges between entrepreneurs and traditional banks Fast money often leads to expensive, dangerous debt Merchant cash advances should be avoided whenever possible Mission‑driven lenders look at the whole entrepreneur, not just numbers Strong lender relationships protect businesses during uncertainty Capital should empower growth—not take control of your company Notable Quotes “Just because a bank says no doesn’t mean that’s the end of your road.” “We’re not just looking at your credit score—we’re looking at you as a whole entrepreneur.” “Capital readiness is not about desperation; it’s about preparation.” “If you’re sitting on a merchant cash advance loan right now, you are not stuck.” “Nothing makes me happier than seeing clients realize their dreams and grow into multimillion‑dollar businesses.” “You should talk to multiple lenders—but you should always understand the real cost of the money.” Conclusion Sahra Halpern’s interview serves as a practical roadmap and a cautionary lesson for small business owners navigating today’s uncertain economic landscape. It reinforces that access to capital is about strategy, education, and relationships, not just approval or rejection. The conversation encourages entrepreneurs to reclaim power, avoid predatory financing, and partner with institutions that are committed to their long‑term success and community impact. #SHMS #BEST #STRAWSupport the show: https://www.steveharveyfm.com/See omnystudio.com/listener for privacy information.