Podcasts about Lactobacillus

Dr. Don and Professor Ben talk about the risks from eating pease porridge in the pot, nine days old. Dr. Don - risky ☣️ Professor Ben - risky ☣️ Pease pudding - Wikipedia 249. Bringing Frozen Unrefrigerated Peameal Bacon Across the Border — Risky or Not? Growth of Bacillus cereus in fermenting tempeh made from various beans and its inhibition by Lactobacillus plantarum - PubMed Tyndallization - Wikipedia Fractional sterilization" or "intermittent processing - Healthy Canning in Partnership with Facebook Group Canning for beginners, safely by the book The Journal of Hygiene - Google Books

Does GABA Actually Help With Sleep? What the Research Says for Brain Injury Recovery Someone in our community recently asked me about GABA for sleep. They’d seen it recommended online, understood that sleep was critical for their recovery, and wanted to know whether the supplement was worth exploring or just noise. It’s a genuinely good question. And it deserves a proper answer. In this post, I’m going to walk you through what GABA is, what the clinical research actually shows about its effect on sleep, why the blood-brain barrier debate matters (and why it might not derail the whole argument), and what the evidence says about the relationship between sleep and brain recovery. By the end, you’ll have enough to have an informed conversation with your medical team. I’m not a doctor. I’m a three-time haemorrhagic stroke survivor who has spent years researching the science of brain recovery and interviewing hundreds of clinicians and survivors on the Recovery After Stroke podcast. What I offer is a careful read of the evidence, not a clinical prescription. What Is GABA and Why Does It Matter for Sleep? GABA (gamma-aminobutyric acid) is the brain’s primary inhibitory neurotransmitter. If your nervous system were a car, GABA is the brake pedal. It reduces neuronal excitability, quiets cortical arousal, suppresses the brain’s primary arousal centre (the locus coeruleus), and modulates the HPA axis, the stress-response system that drives cortisol. Most sedative medications work by amplifying GABA activity. Benzodiazepines, for instance, bind to GABA-A receptors to increase chloride channel opening, producing their calming effect. GABA isn’t doing something unusual here – it’s doing something fundamental. The question with supplemental oral GABA is more specific: Does taking GABA as a capsule or powder actually produce meaningful neurological effects? What Does the Research Show? Finding 1 — Oral GABA Reduces Sleep Latency (and EEG Can Measure It) A 2015 clinical trial published in the Journal of Nutritional Science and Vitaminology by Yamatsu and colleagues used EEG measurement, actual brainwave monitoring, rather than self-reported sleep questionnaires. One hundred milligrams of oral GABA shortened sleep latency (time to fall asleep) by 5.3 minutes compared to placebo. That might sound modest. But for someone lying awake for 30–40 minutes each night, it’s a meaningful shift. Crucially, this was objective neurophysiological data, not a survey response. (PMID: 26052150) Finding 2 — A 90-Day RCT Showed Improved Sleep Efficiency and Mood A 2024 randomised double-blind placebo-controlled trial published in the Journal of Dietary Supplements (Guimarães et al.) gave 200 mg of GABA daily for 90 days to sedentary overweight women also undergoing an exercise program. The GABA group showed significantly improved Pittsburgh Sleep Quality Index (PSQI) scores, significantly reduced depression scores, and improved heart rate variability, a marker of parasympathetic nervous system activity. The HRV finding is particularly interesting. It suggests GABA may be doing something broader than simply reducing sleep latency – it appears to support the overall physiological state that makes rest restorative. (PMID: 38321713) Finding 3 — But a High-Dose RCT Found No Effect Here’s where intellectual honesty matters. A 2023 Dutch RCT (de Bie et al.) published in the American Journal of Clinical Nutrition gave participants 500 mg of GABA three times daily, 1,500 mg/day total, and found no significant effect on self-reported sleep quality. Fasting plasma GABA wasn’t significantly elevated either, raising real bioavailability questions at that dose. This isn’t a reason to dismiss GABA entirely. It is a reason to pay attention to the dose. The evidence base supports 100–300 mg, not 1,500 mg. Higher is not better, and the non-linear dose response is clinically important. (PMID: 37495019) The Blood-Brain Barrier Debate — and Why the Gut May Be the Point The most common objection to oral GABA supplementation is this: GABA is a zwitterion at physiological pH, meaning it has low lipophilicity and poor predicted ability to cross the blood-brain barrier via passive diffusion. So if it can’t get into the brain directly, how does it produce neurological effects? The emerging explanation involves the gut-brain axis. The enteric nervous system, your gut’s own neural network, has GABA receptors. When oral GABA activates these enteric receptors, it can signal the brain via vagal afferents without needing to cross the BBB at all. Think of it as a side door rather than the front entrance. Supporting this: a 2024 RCT (Li et al.) found that a probiotic strain engineered to increase gut GABA production significantly improved objective sleep duration as measured by wearable devices, alongside reduced cortisol and suppressed HPA axis activity. The mechanism wasn’t direct CNS access – it was gut-brain signalling. (PMID: 39385735) The BBB debate doesn’t negate the clinical effect. It changes how we understand the mechanism. Why Sleep Is Not Optional in Brain Recovery This is the part that I think gets underweighted in recovery conversations — and the research is unambiguous. A 2026 large retrospective cohort study (Muhtar et al., Sleep Medicine) matched over 35,000 stroke patients and found that post-stroke insomnia was associated with a 29% higher risk of post-stroke cognitive impairment and a 30% higher risk of all-cause dementia. The association with Alzheimer’s disease was also significant. (PMID: 41924789) A 2024 observational study from Monash University and Alfred Health (Smith et al.) found that in stroke rehabilitation patients, poor sleep quality was significantly associated with higher fatigue severity and lower salivary BDNF gene expression. BDNF (brain-derived neurotrophic factor) is one of the primary molecular drivers of neuroplasticity. Less BDNF means a less receptive environment for the neurological rewiring that rehab is trying to build. (PMID: 38802847) And then there’s the glymphatic system: the brain’s waste-clearance mechanism that is most active during deep sleep. Poor sleep means reduced clearance of metabolic byproducts, including proteins associated with neurodegeneration. This is not a theoretical risk. It is an active, ongoing process. Sleep is not passive recovery. It is one of the primary mechanisms of recovery. What to Do With This Information Here are three practical steps if you’re exploring GABA for sleep: 1. Measure your sleep baseline first. Use the Pittsburgh Sleep Quality Index (freely available online) before you make any changes. Understanding whether you’re struggling with latency, duration, or quality will determine what you actually need to address. 2. If you trial GABA, choose the right form and dose. Look for PharmaGABA — naturally fermented GABA, derived from Lactobacillus hilgardii, which has the strongest clinical evidence base. A dose of 100–300 mg taken 30–60 minutes before bed is consistent with the positive studies. Avoid very high doses; the null result at 1,500 mg/day is important context. Important drug interaction note: If you are taking benzodiazepines, anticonvulsants (gabapentin, pregabalin, valproate), or any other GABAergic medication, discuss GABA supplementation with your prescriber before adding it. The additive sedative effect is a real risk. The same applies if you drink alcohol regularly. 3. Don’t skip the foundation. Sleep hygiene interventions, consistent sleep and wake times, a dark and cool room, and no screens in the 60 minutes before bed, are consistently among the highest-leverage sleep interventions in the literature. GABA may provide a genuine incremental benefit. But it cannot compensate for a fundamentally disrupted sleep environment. The Bottom Line The evidence for GABA and sleep is more substantive than I expected when I started researching it. The EEG data is real. The 90-day RCT showed meaningful clinical outcomes. The gut-brain axis mechanism is biologically plausible and now has direct RCT support. And the consequences of poor sleep in neurological recovery are not trivial – they are quantifiable, significant, and, to a degree, addressable. GABA is not a guaranteed fix. Individual responses vary. The research is not yet definitive at the level of large multi-centre trials in neurological populations. But as one tool in a comprehensive approach to sleep quality alongside good sleep hygiene, appropriate medical support, and consistent rehabilitation, the case for cautious exploration is reasonable. The next step is a conversation with your neurologist, GP, or rehab physician. Take the research with you if it’s useful. Research References All studies cited in this post are retrievable via PubMed: Yamatsu et al. — GABA sleep latency EEG clinical trial (2015) — PMID: 26052150 Guimarães et al. — GABA 200mg RCT, sleep efficiency + mood (2024) — PMID: 38321713 de Bie et al. — GABA high-dose RCT, null sleep result (2023) — PMID: 37495019 Li et al. — Gut-brain GABA axis and sleep RCT (2024) — PMID: 39385735 Muhtar et al. — Post-stroke insomnia and cognitive decline cohort (2026) — PMID: 41924789 Smith et al. — Sleep, BDNF, and fatigue in stroke rehabilitation (2024) — PMID: 38802847 This post is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before making changes to your supplementation or treatment plan. If you or someone you care about is recovering from a stroke, brain injury, or any neurological condition, the Recovery After Stroke podcast and this blog exist for you. Subscribe on YouTube @BillGasiamis, or visit Recovery After Stroke to find episodes, resources, and community. The post GABA, Sleep, and Brain Health – Neurological Recovery appeared first on Recovery After Stroke.

What if chronic illness was a path towards healing on levels greater than just physical? In this episode of Metabolic Matters, host Christina Mason sits down with Alekha Akkappedi and her longtime best friend, Emily Sullivan, for a powerful, multi-dimensional healing journey. At just 22 years old, pre-med student Alekha's life changed overnight. What began as a simple infection quickly spiraled into a complex web of chronic conditions: POTS, mast cell activation, PCOS, GERD, and connective tissue disease. Left bedridden, her science trained mind begins seeking answers. As she begins to experience healing in modalities outside of her allopathic education, she finds herself asking more questions and embarks on an unexpected career path. Alekha navigates years of uncertainty, traveling on paths that blend science, circadian biology, nutrition, and spiritual practices. Emily shares what it was like to watch her best friend's struggles and triumphs. Her perspective offers insight on the power of friendship and how watching another make healing choices vicariously heals those in close proximity. Alekha and Emily both experience healing as cyclical on many levels. Both agree that HOPE is one of the greatest healers. What unfolds for these two young sages is not just a story of physical recovery but transformation that is intangible, emotional and physical.After almost a decade of research and healing work, Alekha created the ALI Protocol, a comprehensive approach for those dealing with POTS, MCAS and long covid that integrates biology, psychology and energetic practices.

It's easy to think of mental health as something happening only in the brain. But more and more, we're seeing how closely it's tied to what's going on in the gut. Today, I'm joined again by Dr. William Li, a New York Times bestselling author. We discuss his latest book, Eat to Beat Your Diet, and how food, inflammation, and microbiome shape the way we think and feel. Watch the full conversation on YouTube, or listen wherever you get your podcasts - https://youtu.be/rY0OE-1blL0 In this conversation we discuss: • What if your anxiety or brain fog is actually a signal coming from your gut • Why gut health may be the missing piece in how we think about mental health • How everyday foods can either fuel inflammation or help calm your system • The compounds in real food that quietly support memory, mood, and mental clarity • Simple shifts that can help reset your system and support how you feel day to day Mental health isn't separate from the rest of the body. The more we understand that, the more it shifts where you look for answers. If you're looking for more support and community around this, the 10-Day Detox is designed to help reduce inflammation and support your body using real food. View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman's Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Results https://drhyman.com/pages/hyman-hive This episode is brought to you by Korrus, BIOptimizers, Seed, Maui Nui, Made In Cookware and Sunlighten. Visit korrus.com/drhyman for 15% off their newest product OIO Sphere with code HYMANSPHERE15. Head to bioptimizers.com/hyman and use promo code HYMAN at checkout to save 15%. Go to seed.com/hyman and use code 20HYMAN to get 20% off your first month. Go to mauinuivenison.com/hyman to claim your free 6-pack of their Wild Axis Venison Jerky Sticks. Visit madeincookware.com and use code HYMAN10 for 10% off your order. Visit sunlighten.com and use code HYMAN to save up to $1600 today! (0:00) Food as medicine, the flavorome, and the gut-brain connection (3:20) Food, gut health, and mental health (6:02) The flavorome's impact on gut and brain health (10:33) Importance of a balanced gut microbiome (13:35) Feeding the microbiome with polyphenols (21:19) Anti-inflammatory properties of ellagic acid and polyphenols (26:05) Lactobacillus reuteri: benefits for wound healing and mental health (30:12) Natural flavors, phytochemicals, and animal intelligence (38:17) Inflammation, processed foods, and mental health (44:12) Diet's impact on gut health, symptoms, and benefits of cooking (47:50) Polyphenols, brain health, and neurogenesis (55:25) Ibogaine, brain regeneration, and personal experiences (1:00:40) The future of brain and eye health (1:02:28) Upcoming projects, professional advice, and gratitude (1:05:45) Final thoughts, resources, and outro

This episode is brought to you by the⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Primal Tallow Soaps & Balms.⁠⁠⁠⁠⁠⁠ Is your weight loss stall actually a "gut" problem? In this episode, Dr. William Davis (MD), cardiologist and author of the Wheat Belly series and his new book Super Body, joins us to explain how dysbiosis in your gut microbiome is driving the epidemic of visceral fat and heart disease. Drawing on his latest clinical studies, Dr. Davis explains the mechanism of endotoxemia, where bacterial byproducts leak into the bloodstream, triggering systemic inflammation and insulin resistance.In this episode, Dr. Davis explains the specific strains needed to eradicate SIBO, including Lactobacillus gasseri, the updated "36-hour yogurt" protocol, and how the gut microbiome affects heart health beyond weight loss. This conversation provides science-based tools to help restore the microbiome. Whether you are struggling with stubborn belly fat or looking to optimize your cardiovascular markers, Dr. Davis bridges the gap between complex microbiology and practical, simple tips.

In this episode of the Hormone Genius Podcast, we take a deep dive into Chronic Endometritis (CE), an often-missed but highly impactful root cause of infertility, recurrent miscarriage, and abnormal bleeding. This conversation highlights both a breakthrough in diagnosis and a more effective, targeted approach to treatment—offering real hope for women who have long struggled without clear answers. Chronic Endometritis is an inflammatory condition of the uterine lining caused by infection or microbial imbalance. It is frequently confused with endometriosis, yet the two conditions are entirely different in both cause and treatment. At its core, CE reflects a disruption in the uterine microbiome. A healthy environment is dominated by protective bacteria—primarily Lactobacillus—but when this balance is lost, pathogenic bacteria can take hold, leading to chronic inflammation. What makes CE particularly challenging is how subtly it can present. Women may experience infertility, recurrent pregnancy loss, prolonged or irregular bleeding, brown spotting, or persistent mid-cycle mucus. Despite these symptoms, many cases go undiagnosed due to limitations in traditional testing methods. Historically, endometrial biopsy has been the standard diagnostic tool, but it often fails to detect localized infections, resulting in false negatives. This episode explores a game-changing advancement: menstrual blood DNA testing. This non-invasive approach captures a comprehensive sample of the uterine lining during menstruation, providing a detailed analysis of bacterial and yeast composition. The result is a far more accurate diagnosis and the ability to create a truly personalized treatment plan. This phased approach is designed not only to address the infection but also to penetrate deeper, more resistant areas, particularly in cases where infection may be harbored in the male partner. The prostate, with its relatively poor blood supply, can act as a reservoir for bacteria, meaning reinfection is possible if both partners are not evaluated and treated simultaneously. With this comprehensive strategy, treatment success rates approach 90%, a significant improvement over traditional, less targeted methods. For more resistant cases, additional considerations may include immune support with low-dose naltrexone, as well as investigating broader systemic contributors such as chronic infections or environmental exposures. In select cases, more advanced interventions like intrauterine antibiotic infusions may also be considered. This episode ultimately underscores a powerful shift in how we approach fertility challenges—from symptom management to root-cause identification and targeted care. By leveraging better diagnostics and more thoughtful treatment protocols, Chronic Endometritis becomes not just identifiable, but highly treatable, opening the door to restored health and renewed hope for many women. Sponsors

In this episode of The Happy Flosser RDH, Billie breaks down one of the most testable and clinically important topics in dental hygiene: the bacteria associated with different types of dental caries. If you've ever mixed up S. mutans and Lactobacillus, or wondered why Actinomyces matters for root caries, this episode will finally make everything click.You'll learn:• The major bacterial players in caries initiation and progression• Which bacteria are linked to smooth surface, deep dentinal, root, and early childhood caries• The risk level associated with each organism• Easy memory tricks to help you recall them instantly during exams and in clinic• How this knowledge translates into real‑world patient care and risk assessmentThis is the perfect episode for students prepping for boards, reviewing for a caries lecture, or trying to build stronger clinical reasoning. By the end, you'll understand not just who these bacteria are, Why they matter, and how to use this information to better educate and support your patients.Tune in, take notes, and get ready for everything to finally make sense.Additional Information Take the quiz on this content Here Additional resources: Leave me a message or send a question I can share on the Podcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Time Management Prioritization Quiz - Find out how you rate ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠HERE ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Study Sheets: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://thehappyflosserrdh.etsy.com/ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Specialized Course: How to be successful in Dental Hygiene School⁠⁠⁠⁠⁠⁠⁠https://billie-lunt-s-school.teachable.com/p/how-to-be-successful-in-dental-hygiene-school⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Other Podcasts: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠blog.feedspot.com/dental_hygiene_podcasts/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠  Email Me: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠HappyflosserRDH@gmail.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Leave me a message or ask a question I can share on the Podcast ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Here ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Check out my free scorecard for students - you can rank yourself on how you are doing to take action on the steps toward being a successful college student. Study Sheets: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://thehappyflosserrdh.etsy.com/ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Specialized Course: Managing your Stress and Anxiety in Dental Hygiene School:⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://billie-lunt-s-school.teachable.com/p/how-to-be-successful-in-dental-hygiene-school⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Follow Me Social Media:-Facebook: https://www.facebook.com/vivalavulvalaInstagram: https://www.instagram.com/vivalavulvalaWebsite: https://www.vivalavulvala.org/If you've ever finished a round of antibiotics for BV only to find yourself right back where you started — frustrated, confused, and wondering what you're doing wrong — this episode is for you. Internal Medicine physician, Dr. Cara Quant, breaks down the science of your vaginal microbiome in a way that's finally clear, honest, and shame-free. Unlike the gut, a healthy vaginal microbiome is actually low diversity, dominated by specific Lactobacillus species that keep your pH protective and your ecosystem stable. When that balance collapses — whether from BV, yeast, or the lesser-known aerobic vaginitis — it's not a hygiene failure. It's a microbiome problem, and understanding the difference changes everything. Along the way, she tackles the myths you've probably already tried: the yogurt, the douching, the idea that oral probiotics will somehow find their way to where you actually need them.The second half of the episode dives into the question listeners keep asking: do probiotic suppositories actually work? The honest answer is more nuanced than most wellness content will tell you — and that's exactly why it's worth 35 minutes of your time. Dr. Quant walks through the most compelling clinical trial data, explains why strain specificity is everything, and separates what's genuinely promising from what's still unproven. She also covers what evidence-based treatment actually looks like for recurrent BV, which lifestyle factors have real data behind them, and the specific questions you should be asking your doctor if you feel like you're stuck in a loop. Whether you're a patient who's been dismissed too many times or just someone who wants to understand their own body better, this episode will leave you more informed, more empowered, and a lot less alone.

In this episode, SCD Founder and CEO Dr. Matthew Wood talks about the different bacterial residents in the soil and the roles they play.   Subscribe for more content on sustainable farming, market farming tips, and business insights!   Get market farming tools, seeds, and supplies at Modern Grower. Follow Modern Grower:  Instagram  Instagram Listen to other podcasts on the Modern Grower Podcast Network:  Carrot Cashflow  Farm Small Farm Smart  Farm Small Farm Smart Daily  The Growing Microgreens Podcast  The Urban Farmer Podcast  The Rookie Farmer Podcast  In Search of Soil Podcast Check out Diego's books:  Sell Everything You Grow on Amazon   Ready Farmer One on Amazon **** Modern Grower and Diego Footer participate in the Amazon Services LLC. Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.

WATCH THE EPISODE HEREIn this EpisodeHighlights & “Must-Listen” Moments* 0:00 — Welcome to the live, and a tech hiccup: We start strong (one minute early!) before Amy promptly drops off the call. Welcome to live television, folks.* 2:22 — Big announcement — we're moving to Wednesdays at noon ET: David (Fatty Daddy) is almost 66 and exhausted by late-night shows. Starting next week, Talking with My Mouth Full goes live every Wednesday at 12 noon Eastern. West Coasters, that's 9 a.m. Europeans, we see you, too.* 6:20 — Amy's sourdough report: The Miche: Amy's been baking her way through the King Arthur Big Book of Bread, and this week's loaf was a miche — a classic French whole-grain sourdough, deeply tangy, chewy, and wonderfully moisture-retaining. Her starter is named Lazarus (given to her by a pastry chef at The Alna Store in Maine), and the name fits.* 10:28 — David's food week: Lasagna Bianca and the Coca-Cola Brisket Aftermath: David finally had all the right cheeses (ordered from Caputo's) for his five-cheese lasagna bianca, with handmade noodles rolled to setting 6 or 7 — so thin you can see through them. (Marcella Hazan once wrote him to say that's exactly how it should be done.) He also confesses to eating an entire five-pound Coca-Cola brisket over the course of several days. No regrets.* 10:45 — The L. Reuteri Yogurt Rabbit Hole: Amy has gotten into making homemade yogurt using Lactobacillus reuteri, a culture promoted by Dr. William Davis (Wheat Belly) for its alleged gut-health and serotonin-boosting effects. The evidence: her sister-in-law went from tightly wound to noticeably chill. It's made with half-and-half and is genuinely delicious. Amy's verdict: she may have a delightful personality again.* 15:30 — ADHD confessions: David opens up about struggling to function without The One around — 269 unpublished posts sitting in his website backend, four photos from a shoot last June never uploaded, six holiday videos still in draft. Amy relates: She says she's somewhere on the spectrum, and got into a fight with Scott when she started raking leaves at 1 p.m. for a 2 p.m. departure. (She was ready by 2:05, for the record.) Audience members chimed in to share their own experiences.* 22:10 — Books We Love: Morning Baker by Roxana Jullapat: David shares his excitement about this upcoming baking book (drops April 7th), packed with gorgeous recipes from the author of Mother Grains. Donuts, French toast, and beautiful photography — this one earned a “must have the physical copy.”* 24:46 — Amy's Pick: A Kitchen on Goose Cove by Devin Finigan: Amy recommends this forthcoming cookbook from the chef of Aragosta restaurant in Maine, arriving later in April. The restaurant sits at the edge of an enchanted-forest cove overlooking the bay — and the food is just as stunning.* 27:18 — Amy's current read: Le Road Trip by Vivian Swift: A beautifully illustrated chronicle of a honeymoon road trip through France, with sections on Bordeaux's food and wine scene. Swift is an illustrator and writer, and Amy is captivated by the humanity of the hand-drawn work — especially in an AI-saturated moment.* 29:56 — Dorie's Anytime Cakes and the illustrated cookbook debate: David and Amy discuss the reactions to Dorie's latest book, which uses a photorealistic illustration style. Beautiful graphic design, but some readers found it less effective than photographs. The conversation leads to a broader point: in the age of AI perfection, people are gravitating toward the human, the imperfect, the messy, and real.* 33:20 — Product Spotlight: The Rose Levy Beranbaum Reduction Spatula: David finally retrieved it from the kitchen. It's a ThermoWorks product from her Signature Series — a long spatula with raised measurement markings so you can track a sauce as it reduces right in the pan, no pouring into a measuring cup required. You can also use it to check viscosity. David has been trying to show it on the show for three weeks. Worth every penny.* 35:46 — Also worth having: Lucinda Scala Quinn's Spurtles: Amy sings the praises of her spurtles — a cross between a spoon and a spatula, available in solid and slotted versions. Great for flipping pancakes, stirring risotto, and pretty much everything else. A quiet classic.* 37:09 — Food News: The 100-Year Oyster Promise Fulfilled: Wintzell's Oyster House in Mobile, Alabama, had a long-standing promotion: free oysters to any man 80 years old, accompanied by his father. In early 2026, 99-year-old James Rush finally walked in with his 80-year-old son Jimmy to claim it. This is the first time in nearly 100 years the promotion has been fulfilled.* 39:13 — The World's Best Cheese: The World Championship Cheese Contest recently crowned the Beemster Royaal Grand Cru — a 12-month-aged Gouda made by a cheesemaker with a Royal Warrant from the Netherlands — as best in show. The cows graze on seagrass near the ocean; the resulting milk delivers butterscotch and toasted almond notes. It is available at specialty cheese shops in the U.S.* 41:03 — Amy's personal favorite: Abbaye de Belloc: A butterscotch-nutty, alpine-style cheese from the Pyrénées in the Comté family, made by affineur Mons and sold at Formaggio Kitchen in Cambridge (which has an in-store aging cave and an online shop).* 43:07 — A love letter to Queijo Serra da Estrela: David raves about Portugal's greatest cheese — an oozy, thistle-rennet sheep's milk cheese from the Serra da Estrela mountains. He recalls a peak life moment at Quinta do Crasto in the Douro, when a nearly empty wheel arrived at the table, spaghetti swirled in the gooey inside with just black pepper. Nearly impossible to find properly aged in the U.S.* 48:35 — So long, and see you Wednesday at noon: Thank you for joining us. The Prosecco is gone, Amy is laughing, and we'll see you next Wednesday at 12 noon Eastern.Products We Love* Rose Levy Beranbaum's Reduction Spatula (ThermoWorks Signature Series) — A long spatula with raised measurement markings for tracking sauce reductions right in the pan. Also useful for checking viscosity. An absolute game-changer for anyone who reduces stocks, sauces, or caramels.* Lucinda Scala Quinn's Spurtles — A cross between a spoon and a spatula, available in solid and slotted versions. Great for stirring, flipping, and doing basically everything at the stove.Books and Publications* Morning Baker by Roxana Jullapat — A baking book dropping April 7th, from the author of Mother Grains* A Kitchen on Goose Cove by Devin Finigan — From the chef of Aragosta restaurant in Maine; coming May 19, 2026.* Le Road Trip by Vivian Swift — Illustrated travel memoir covering a honeymoon journey through France* Dorie's Anytime Cakes by Dorie Greenspan — Out now; photo-realistic illustration style sparked a lively debate* Wheat Belly by Dr. William Davis — The classic tome on eliminating wheat from your diet and whyRecipes* Sourdough Miche (French whole-grain sourdough)* Porridge Bread* L. Reuteri Yogurt (made with half-and-half)* Lasagna Bianca with Five Cheeses (with handmade pasta)* Coca-Cola Brisket* Pastéis de Nata (Portuguese Custard Tarts)Where to Find Us* Amy Traverso* Instagram | Yankee* David Leite* Leite's Culinaria | Instagram | Pinterest | Facebook | YouTubeChow,David This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit davidleite.substack.com

Many farmers assume glyphosate is a reliable tool for weed control with minimal downsides, but Dr. Michael McNeill shows how this herbicide quietly disrupts the very foundation of productive farming—from soil biology to crop health and long-term field resilience. In this eye-opening episode, Dr. McNeill explains the hidden journey of glyphosate through the farm system: how it lingers in manure from treated feed, carries over to contaminate even organic fields, and boosts pathogenic fungi and other disease pressures that hit yields hard. He shares research revealing glyphosate's antibiotic-like effects on soil microbes—shifting the microbial balance, weakening natural disease suppression, and making plants more vulnerable to outbreaks that cost farmers in inputs and lost production. You'll hear about practical, farmer-tested ways to fight back, including using raw sauerkraut juice (loaded with beneficial fermentative microbes like Lactobacillus plantarum) to rapidly break down glyphosate residues in soil and feed crops—potentially slashing contamination by 80-90% in just months and freeing up bound nutrients for better plant uptake. The discussion dives deep into proven regenerative strategies to reclaim fields: strategic cover crops, targeted microbial inoculants, balanced soil nutrition, and other biological practices that naturally crowd out weeds, curb pests and diseases, and rebuild robust soil structure—without leaning on chemicals that create dependency and hidden costs over time. This episode lays bare how over-reliance on glyphosate often leads to nutrient lockups, escalating disease pressure, and rising input needs that eat into profits. But it also delivers real hope: a path to more resilient crops, healthier soils, lower long-term costs, and stronger farm sustainability. Ideal for row-crop farmers, livestock producers, agronomists, and anyone managing land who wants to cut through the noise and explore science-backed ways to reduce chemical dependency while boosting productivity and soil vitality. If you're ready to rethink weed management and invest in farming biologically, this conversation is essential listening. Read the journal article here: https://journals.ashs.org/view/journals/hortsci/59/11/article-p1618.xml About Dr. Michael McNeill: Over the past four decades, Dr. McNeill's focus as an agronomist has been in teaching the agricultural community an understanding of soil and plant nutrition, emphasizing its' importance for animal and human health. His emphasis has been placed on developing farming systems that promote soil and plant health, as well as, conducting on farm research to develop efficient bio-remediation of soil and water contaminated with farm chemicals and fertilizer nutrients. Also, a major focus of his has been to teach farmers methods to evaluate soil health by measuring soil microbial life, water infiltration rates, soil density, soil compaction, soil fertility levels and how to develop corrective measures if problems are discovered. Positions, Scientific Appointments 1983 – Present President of Ag Advisory, Ltd. (an agricultural consulting company) 1971 – 1983 Research Scientist and Manager of a regional corn breeding station located in Algona, Iowa. 1969 – 1971 U.S. Army research pathologist, study of soybean and corn disease epiphytology. 1964 – 1969 Iowa State University, research associate. Contributions to Science: Published papers in the following: Crop Science, Horticulture Science, Egyptian Journal of Genetics, Plant Disease Reporter, Journal of Genetics, Journal of Economic Entomology, Agronomy Journal, Iowa State University Extension Service Bulletins Popular Press articles: Farm Journal, Successful Farming, Farm Industry News, Iowa Farmer Today, Soybean Digest, Furrow

Send us Fan MailYou've tried probiotics. They helped — for a little while. Then the bloating came back. The reactivity returned. Whatever shift you felt didn't hold.So you tried something else. Different probiotic, different protocol, different elimination approach. Same pattern. Brief improvement, then backslide.It's not that nothing helps. It's that nothing holds.In this episode I'm going to tell you why. And it's probably not what you think.The problem isn't the wrong probiotic or a diet that isn't strict enough. The problem is that your gut ecosystem has lost its keystone species — the specific organisms that hold the entire system together. And until those are restored, nothing you add is going to stick.I walk through who the keystone species are and what they actually do — Faecalibacterium prausnitzii, Akkermansia, Bifidobacterium, Lactobacillus reuteri, Roseburia — and what the whole system loses when they go missing. Why butyrate production drops and what that costs your gut lining, immune function, motility, and mood. Why fermentation shifts from fiber to protein and produces inflammatory compounds that drive reactivity and brain fog. And why opportunistic species expand — not because they invaded, but because the space opened up.I also cover what disrupts keystone species in the first place — antibiotics, low fiber diversity, chronic stress, mold exposure, common medications — and what restoration actually requires, in the right sequence, at the pace your system can absorb.If you've been doing gut work and keep hitting the same ceiling, this episode will reframe what's been missing.read the full blog post hereSupport the showSupport the podcast  Mineral Foundations Course HEREMinerals & Microbes package HERERewilded Wellness program HEREJoin my newsletter HERE If you are interested in becoming a client and have questions, reach out by emailing me: lydiajoyme@gmail.com  Find me on Instagram : @ Lydiajoy.me

Sugar restriction during the first 1000 days of life may slash heart risk decades later; Are some people more genetically-adapted to the cold? While GLP-1 drugs may shrink muscle, new study confirms natural weight loss diets don't. Should strength assessments be added to routine physicals to forecast risk of dying? For gut health, take your microbiome for a run! Strontium safety and effectiveness; What are dietitians missing about GLP-1 drugs.

How did Noon Whistle Brewing create a West Coast IPA with bold hop flavor but none of the harsh bite that turns skeptics away?From late hopping techniques and water chemistry to managing bitterness perception and “yeast afterbite,” the Noon Whistle team discusses how drinkability became their competitive advantage. Paul Kreiner (Co-Owner & Brewmaster), Mike Condon (Co-Owner), and Joe Condon (Marketing & Creative Director) share how that philosophy helped them win gold with an amber lager, experiment with wild fermentation (including beers that “sucked for a year”), and build a brand that balances hype with approachability.0:00 From Session Beers to Gold Medals at Noon Whistle3:20 The Story Behind the Noon Whistle Name6:22 Why They Started With Low ABV Session Beers8:50 How Drinkers Think About ABV vs Taste9:56 What Is “Yeast Afterbite” in Beer?10:36 How Paul & Mike Decided to Open a Brewery11:59 From Homebrewer to Siebel Institute Graduate13:58 Does Chicago Have the Best Water for Brewing?14:54 Would You Taste a Water Profile Change?16:43 How the Craft Beer Business Has Changed in 10 Years18:34 How Noon Whistle Built Wide Distribution in Illinois19:50 Joe Condon's Branding Strategy & Costco Packaging23:44 Describing the “Baby Case” 24-Pack Box29:49 Hop Prism Blue: A Less-Bitter West Coast IPA38:48 Bruski Amber Lager Wins World Beer Cup Gold39:57 Amber Ale vs Amber Lager: What's the Difference?43:06 What It's Like to Win World Beer Cup Gold45:39 Funderen Wild Sour & FOBAB Silver Medal55:08 How Important Is Barrel Aging to Noon Whistle?57:43 Barrel-Aged S'more Nutz Stout59:28 Does Every Chicago Brewery Need Barrel Aging?1:03:32 The Intense R&D Behind Their Tavern-Style Pizza1:07:00 Pause & Pause Plus THC Sparkling Water1:16:26 The Final Four Questions1:22:47 Favorite Beer & Food PairingsAbout Noon Whistle Brewing: Noon Whistle officially opened its doors in 2014 with the original production facility and tasting room in Lombard, IL. Before long, Noon Whistle branched out beyond only producing styles with lower ABV to include hazy, hoppy, sours and everything in between. Learn more on their website at https://www.noonwhistlebrewing.com/ —You can learn more about Crafty Brewers and get in touch with us on our official website, https://craftybrewerspod.com Crafty Brewers is a production of Quantum Podcasts, LLC, a podcast growth consultancy that helps brands turn niche audiences into loyal customers. If you're ready to build authority, drive measurable results, and grow through podcasting, visit https://quantum-podcasts.com/Our executive producer and editor is award-winning podcaster Cody Gough. He insists that we tell you that in this episode, you'll learn about: Hop Prism Blue, Bruski Amber Lager, Funderen Wild Sour, Barrel-Aged S'more Nutz, Pause THC Sparkling Water, Pause Plus THC Sparkling Water, World Beer Cup, Festival of Wood & Barrel-Aged Beer (FOBAB), hazy IPA, American IPA, session beers, low ABV beer strategy, bitterness perception, IBUs, dry hopping techniques, hop flavor vs bitterness, amber ale vs amber lager differences, lager fermentation vs ale fermentation, Brettanomyces, Lactobacillus, Pediococcus, mixed culture fermentation, bourbon barrel aging, craft beer distribution strategy, and cream ale controversy.

Why has yogurt making gone viral?First of all, it's NOT yogurt. It looks and smells like yogurt. By FDA regulations, something called yogurt must be fermented with traditional yogurt-making microbes Lactobacillus bulgaricus and Streptococcus thermophilus. That's NOT what we are doing. Instead, we are fermenting human microbes, i.e., microbes that are adapted to the human body and provide substantial benefits but have been lost by most people because of their susceptibility to common antibiotics. Using my methods (prolonged fermentation, addition of prebiotic fiber, selecting microbial species to achieve specific effects) we obtain hundreds of billions of microbes per serving for greater benefits. These are the concepts I introduced in my Super Gut book and extended further in the Super Body book. Support the showYouTube channel: https://www.youtube.com/@WilliamDavisMD Blog: WilliamDavisMD.com Membership website for two-way Zoom group meetings: InnerCircle.DrDavisInfiniteHealth.com Books: Super Gut: The 4-Week Plan to Reprogram Your Microbiome, Restore Health, and Lose Weight Wheat Belly: Lose the Wheat, Lose the Weight and Find Your Path Back to Health; revised & expanded ed

本次過年大夥很勇 益生菌百百種，常常不知道怎麼選哪款益生菌是最有效嗎? 善存3效順暢益生菌，雙專利益生菌添加鳳梨酵素，順暢消化好體質，一包三效，有酵才推薦！ 善存70年專業品牌，這款3效順暢益生菌，「雙專利益生菌、搭配鳳梨酵素」幫助你養出消化道好環境#。雙專利益生菌^，讓你代謝順暢#，大大乾淨，維持健康，人自然年輕；還有添加鳳梨酵素，加速分解蛋白質，消化更有感，有酵才敢推薦給你。 另外，善存還有舒眠益生菌，食品級植萃成份，擁有五大晚安因子：添加專利舒眠番紅花*、多國專利益生菌**、GABA***、芝麻素****、色胺酸等，可以幫助放鬆、好入睡！讓你天天吃好安心，想睡就睡、睡醒精神好^^! 好菌天天吃，養成好體質，天天精神好。投資財富靠自己，投資健康就讓善存來幫你！ 新春甚麼攏馬順! 益生菌限定優惠! 即日起到2/28 止, 上momo購買善存/挺立/克補保健產品滿2499就送3效順暢益生菌粉末顆粒40包一盒! 好吃又有效益生菌滿額免費送給你! #改變細菌叢生態、維持消化道機能、調整體質 ^係指Lactobacillus paracasei、Bifidobacterium lactis、Lactobacillus plantarum之專利 ‘維持消化道機能, 維持健康 *植萃番紅花萃取物 **日本、中華民國、美國、中國 ***麩胺酸發酵物(含GABA) ****芝麻萃取物(含芝麻素) ^^晚上幫助入睡、白天精神旺盛 PM-TW-CNT-26-00012 股癌傳送門：linktr.ee/gooaye -- Hosting provided by SoundOn

Can specific gut and mouth bacteria influence brain health and conditions like Parkinson's or Alzheimer's? We look at early clinical work on Lactobacillus plantarum PS128 and its potential to slow Parkinson's progression, links between gum disease and dementia, and how Lactobacillus reuteri may stimulate oxytocin. This clip explores the gut-brain and oral-brain connections, the idea of a brain microbiome, and emerging views on brain regeneration and healthy aging. ***This episode is sponsored by:NOWATCH: The compassionate health trackerConnecting body and mind with unique stress recovery insights so you can live fully today15% off with code LWBW15 at https://nowatch.com/Mojo: the app for expert-led courses in better sex.Learn from world-class sex therapists and relationship experts with courses tailored to your needs.15% off with code LiveWell15 at mymojo.com/livewellbewell***The Great British Veg OutHow to support your gut, energy, and hormones by eating more — not less.

In this episode of Sexy Sips, Angie, Elizabeth, and Flora discuss some of the most common vaginal and sexual health myths. We break down what the science actually says about vaginal probiotics and Lactobacillus strains, why pineapple juice became a social media obsession, how cultural bias shapes how we view pubic hair, and what's really inside Royal Honey packets.

HEALTH NEWS   Probiotics emerge as a potent tool against depression and anxiety Altered microbiome: Oral bacteria play a role in chronic liver disease, study reveals Health issues linked to cosmetic jab complications From yoga to awe walks: Many paths lead to better mental health, largest analysis of well-being interventions finds Weight loss drugs may cause nutritional deficiencies without proper guidanc       Probiotics emerge as a potent tool against depression and anxiety University of Calgary (Canada), January 14 2026 (Natural News) For decades, the standard pharmaceutical approach to treating depression and anxiety has dominated treatment options, despite significant drawbacks including delayed effects, debilitating side effects and high relapse rates. Now, compelling new research is challenging this paradigm by pointing to a surprising source of relief: the gut. A comprehensive scientific analysis, synthesizing data from over 1,400 clinically diagnosed patients, reveals that probiotics—beneficial bacteria readily available as supplements—can produce substantial reductions in both depressive and anxious symptoms.   The analysis major findings include:     A major analysis of 23 clinical trials finds probiotics can significantly reduce symptoms of depression and anxiety in clinically diagnosed patients.   The benefits, appearing within 4-8 weeks, were comparable to some conventional antidepressants but without the same side-effect profile.   The gut-brain axis, a communication network largely ignored by conventional psychiatry, is central to understanding this connection.   Single-strain probiotic supplements, particularly certain Lactobacillus and Bifidobacterium species, showed the strongest mental health effects.   This research supports a holistic view of mental wellness, where gut health is a foundational component of treatment.     Altered microbiome: Oral bacteria play a role in chronic liver disease, study reveals Technical University Munich (Germany), January 15 2026 (Medical Xpress) Each year, more than two million people die from advanced chronic liver disease (ACLD). Previous research has linked gut microbiome disruptions to this condition and suggested that bacteria typically found in the mouth may colonize the gut. A new study published in Nature Microbiology now shows that identical bacterial strains occur in both the mouth and gut of patients with advanced chronic liver disease and also reveals a mechanism by which oral bacteria affect gut health. The researchers also found that this process coincides with worsening liver health. Researchers analyzed bacterial populations in saliva and stool samples from patients. The team found that both the gut and oral microbiome undergo significant changes as liver disease worsened, where changes to the oral microbiome were already detectable at earlier disease stages. In healthy individuals, bacterial communities differ substantially between body sites. In patients with liver disease, however, oral and gut microbiomes became increasingly similar as the disease progressed and nearly identical bacterial strains were recovered from the mouth and gut of patients. "These strains are typically found in the mouth and are rarely present in the healthy gut. However, we observed increases in the absolute abundances of these oral bacteria in patients with advanced chronic liver disease. This strongly suggests that these bacteria translocate from the mouth and colonize the gut," explains Melanie Schirmer, Professor of Translational Microbiome Data Integration at TUM.   Health issues linked to cosmetic jab complications Anglia Ruskin University (UK), January 9 2026 (Eurekalert)   Patients with chronic illnesses face a significantly higher risk of complications from cosmetic botulinum toxin injections, commonly known as Botox, according to a major UK study. Researchers from Anglia Ruskin University (ARU) surveyed 919 adults who had received botulinum toxin treatments for aesthetic reasons. The study, published in Aesthetic Surgery Journal, is the largest of its kind to have been carried out in the UK. Botulinum toxin injections are among the UK's most popular cosmetic procedures, with an estimated 900,000 treatments performed every year. Researchers found that underlying conditions such as type 1 diabetes, thyroid disorders, chronic migraine and skin disease dramatically increase the likelihood of adverse effects. According to the study, people with type 1 diabetes were 92 times more likely to experience nausea after treatment compared to those without the condition. Those with thyroid disorders and chronic migraine sufferers had an approximately 10-fold increase in the risk of nausea. Other complications associated with pre-existing conditions included headaches, bruising, muscle weakness and persistent eyelid droop (ptosis). Patients with cataracts were 30 times more likely to report headaches, and those with prior injuries had a 21-fold increased risk of losing facial expression.   From yoga to awe walks: Many paths lead to better mental health, largest analysis of well-being interventions finds Swansea University (UK), January 15 2026 (Medical Xpress) New research by Swansea experts has provided the largest ever comparison of well-being-focused interventions delivered to adults. The team reviewed 183 randomized controlled trials, representing almost 23,000 participants, and evaluated 12 categories of interventions ranging from psychological, physical, mind–body, and nature-based approaches to find out more. Their research was the first interdisciplinary comparison carried out across psychological, physical, mind-body and environmental interventions. The study gives an integrated view of how different disciplines contribute to well-being. By focusing on general adult samples rather than clinical groups, it provides evidence that will be relevant to developing public health, education, workplace well-being, and community programs. The researchers' key findings were: Most interventions improved well-being compared with inactive control groups; Strongest effects were found for combined exercise plus psychological interventions (for example, awe walks or meditation combined with walking); Mind–body interventions showed consistently moderate, reliable effects; Exercise alone produced similar benefits to many psychological interventions; and, Positive psychology interventions—both single-component and multicomponent—were also effective. The analysis shows that there is no single route to improving well-being. Mindfulness, compassion-based approaches, yoga, exercise and positive psychology interventions all showed moderate benefits compared with control groups, and combining physical activity with psychological interventions appeared particularly promising.   Weight loss drugs may cause nutritional deficiencies without proper guidance     University College London & Cambridge, January 7 2026 (News-Medical) People prescribed the new generation of weight loss drugs may not receive sufficient nutritional guidance to support safe and sustainable weight loss, leaving them vulnerable to nutritional deficiencies and muscle loss, say experts at UCL and the University of Cambridge. In research published today in Obesity Reviews, the team found a lack of robust evidence surrounding nutritional advice and support and the impact this has on factors such as calorie intake, body composition, protein adequacy, and patient experiences. Weight loss drugs such as semaglutide and tirzepatide – available under brand names including Ozempic, Wegovy and Mounjaro – mimic the naturally-occurring hormone glucagon like peptide-1 (GLP-1), released into the blood in response to eating. The drugs suppress appetite, increase a feeling of being full, and reduce food cravings. These drugs can reduce calorie intake by between 16-39 %, making them a powerful tool to help people living with obesity and being overweight. However, there has been little research to examine their impact on diet quality, protein intake, or adequacy of micronutrients (vitamins and minerals). The researchers identified just 12 studies that looked at nutrition and diet alongside treatment with semaglutide or tirzepatide. Given the widespread – and increasing – use of these medications and the urgency of providing advice to individuals using the drugs, there was insufficient evidence from the studies to recommend strict low-fat diets to complement the weight loss drugs. Some observational studies found that people on the treatments often consumed excessive levels of total and saturated fat. These medications are transforming obesity care, but we know very little about how they shape people's daily lives, including changes in appetite, eating patterns, wellbeing, and quality of life.

Broadcast from KSQD, Santa Cruz on 1-08-2026: Dr. Dawn concludes her 2025 medical advances recap, noting that while GLP-1 weight loss drugs showed unexpected benefits for addiction, schizophrenia, and dementia risk, Novo Nordisk recently reported semaglutide had no effect on cognition in people with existing dementia or mild cognitive impairment. She describes the first successful human bladder transplant performed on May 4th. The 41-year-old recipient received both kidney and bladder due to the bladder's complex blood vessel network. Surgeons practiced on cadavers with active circulation before achieving success, opening pathways for future bladder-only transplants for the 84,000 Americans diagnosed with bladder cancer annually. An emailer follows up about purslane for cognitive health. Dr. Dawn reviewed the referenced studies and found neither actually supported claims about purslane and cognition—one discussed the Lyon Heart Study's Mediterranean diet, the other described antioxidant properties. She cautions listeners that websites citing "scientifically proven" claims often reference articles that don't support their assertions. An emailer asks about statin alternatives after developing severe muscle pain on both atorvastatin and rosuvastatin. Dr. Dawn suggests he shouldn't be on statins given his classic adverse reaction. She recommends ezetimibe plus oat bran for cholesterol, metformin for his elevated triglycerides indicating insulin resistance, and checking LDL particle size and inflammation markers. She emphasizes that cholesterol is a risk factor, not a disease, and treating 50 low-risk people for 10 years prevents only one heart attack. A caller discusses plaque formation theory, comparing it to calluses. Dr. Dawn explains Linus Pauling's similar hypothesis that plaque forms at vessel bifurcations to protect against turbulent blood flow damage. She warns against driving total cholesterol below 130, as it disrupts steroid hormone production. The caller shares his mother's near-fatal rhabdomyolysis from statins—muscle breakdown releasing myoglobin that clogs kidneys—and criticizes data transfer failures between hospital systems. An emailer reports four UTIs in two months at age 79. Dr. Dawn questions whether all were true infections, since vaginal contamination causes false positives on dipstick tests. For confirmed UTIs, she recommends D-mannose and cranberry to prevent bacterial adhesion, post-void residual ultrasound to check for incomplete emptying, lactobacillus probiotics, and vaginal DHEA (Intrarosa) to restore mucosal thickness and disease resistance. Dr. Dawn describes Stanford's Phase III trial for dystrophic epidermolysis bullosa, where defective collagen-7 causes skin layers to separate at the slightest touch. Researchers take patient skin biopsies, use retroviruses to insert corrected genes, grow credit-card-sized skin grafts over 25 days, then suture them onto wounds. At 48 weeks, 65% of treated wounds fully healed versus 7% of controls. She reports a Stanford study showing premature babies who heard recordings of their mothers reading for 2 hours 40 minutes daily developed more mature white matter in language pathways. The left arcuate fasciculus showed greater development than controls, demonstrating how early auditory stimulation shapes brain circuitry even in NICU settings. Dr. Dawn concludes with tattoo safety concerns. Modern vivid inks contain compounds developed for car paint and printer toner, including azo dyes that break down into carcinogenic aromatic amines—especially during laser removal. Pigment particles migrate to lymph nodes and persist in macrophages, causing prolonged inflammation. She advises those with tattoos to avoid laser removal, wear sunscreen, practice lymphatic hygiene, and reconsider extensive new tattoos.

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3243: Hrefna Palsdottir explores how specific probiotic strains may aid in weight loss by improving gut health, reducing inflammation, and regulating appetite-related hormones. The article highlights evidence supporting the role of Lactobacillus and Bifidobacterium strains in lowering belly fat and preventing weight gain, offering a natural complement to a healthy lifestyle. Read along with the original article(s) here: https://www.healthline.com/nutrition/probiotics-and-weight-loss Quotes to ponder: "Probiotics may reduce the number of calories you absorb from food." "Evidence indicates that Lactobacillus gasseri may help people with obesity lose weight and waist circumference." "Certain probiotic strains, such as VSL#3, may be able to reduce weight gain." Episode references: Lactobacillus gasseri and weight loss (PubMed): https://pubmed.ncbi.nlm.nih.gov/24912386/ VSL#3 Probiotic Blend (VSL#3 Official Site): https://vsl3.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3243: Hrefna Palsdottir explores how specific probiotic strains may aid in weight loss by improving gut health, reducing inflammation, and regulating appetite-related hormones. The article highlights evidence supporting the role of Lactobacillus and Bifidobacterium strains in lowering belly fat and preventing weight gain, offering a natural complement to a healthy lifestyle. Read along with the original article(s) here: https://www.healthline.com/nutrition/probiotics-and-weight-loss Quotes to ponder: "Probiotics may reduce the number of calories you absorb from food." "Evidence indicates that Lactobacillus gasseri may help people with obesity lose weight and waist circumference." "Certain probiotic strains, such as VSL#3, may be able to reduce weight gain." Episode references: Lactobacillus gasseri and weight loss (PubMed): https://pubmed.ncbi.nlm.nih.gov/24912386/ VSL#3 Probiotic Blend (VSL#3 Official Site): https://vsl3.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Former interventional cardiologist Dr. William Davis left traditional cardiology after his mother died months after a successful angioplasty. What he discovered challenges everything mainstream medicine teaches about heart disease.Standard cholesterol testing is outdated. The real drivers of cardiovascular disease are small LDL particles created by wheat, grains, and sugars, amplified by gut microbiome disruption. Coronary calcium scores predict heart attacks far better than cholesterol levels, yet conventional treatments like statins show zero impact on plaque progression.Dr. Davis reveals how antibiotic overuse has left half the US population with small intestinal bacterial overgrowth, driving not just digestive issues but heart disease, obesity, autoimmune conditions, and neurological decline. Eliminating wheat and grains while restoring beneficial bacteria like Lactobacillus reuteri can make dangerous particles disappear.He also exposes the dangers of conventional weight loss: calorie restriction causes 25% muscle loss, permanently slowing metabolism and leading to early death despite temporary improvements. His new book Superbody offers an alternative focused on muscle preservation and microbiome restoration.This conversation fundamentally reframes how diet, gut health, and heart disease connect.Contact Info : Dr. William Davis - Facebook: https://www.facebook.com/drwilliamdavishealth/ Website: williamdavismd.com LinkedIn: https://www.linkedin.com/in/drwilliamdavis/ Follow Dr. Ovadia: Twitter: @iFixHearts Website: OvadiaHeartHealth.com Metabolic Health Quiz: iFixHearts.com Send Dr. Ovadia a Text Message. (If you want a response, you must include your contact information.) Dr. Ovadia cannot respond here. To contact his team, please send an email to team@ifixhearts.com Like what you hear? Head over to IFixHearts.com/book to grab a copy of my book, Stay Off My Operating Table. Ready to go deeper? Talk to someone from my team at IFixHearts.com/talk.Stay Off My Operating Table on X: Dr. Ovadia: @iFixHearts Jack Heald: @JackHeald5 Learn more: Stay Off My Operating Table on Amazon Take Dr. Ovadia's metabolic health quiz: iFixHearts Dr. Ovadia's website: Ovadia Heart Health Jack Heald's website: CultYourBrand.com Theme Song : Rage AgainstWritten & Performed by Logan Gritton & Colin Gailey(c) 2016 Mercury Retro RecordingsAny use of this intellectual property for text and data mining or computational analysis including as training material for artificial intelligence systems is strictly prohibited without express written consent from Dr. Philip Ovadia.

Les probiotiques sont des micro-organismes vivants – le plus souvent des bactéries lactiques ou des bifidobactéries – que l'on retrouve dans certains aliments fermentés ou sous forme de compléments. Lorsqu'ils sont consommés en quantité suffisante, ils peuvent interagir avec le microbiote intestinal, renforcer la barrière digestive et moduler certaines voies immunitaires. Leur rôle potentiel dans la prévention des rhumes vient précisément de cette capacité à influencer l'activité des cellules immunitaires présentes dans l'intestin, où se trouve près de 70 % du système immunitaire humain.Est-ce qu'ils préviennent réellement les rhumes ? Les données scientifiques sont intéressantes, mais nuancées.La synthèse la plus solide reste la méta-analyse Cochrane publiée en 2022. Elle regroupe 24 essais randomisés incluant environ 6 950 participants, enfants et adultes. Les probiotiques y réduisent d'environ 24 % le nombre de personnes ayant au moins une infection respiratoire aiguë, d'environ 18 % l'incidence globale des épisodes, et raccourcissent chaque rhume d'un peu plus d'une journée. Ils diminuent aussi le recours aux antibiotiques. Toutefois, la qualité globale des preuves est jugée de faible à modérée, notamment en raison de protocoles très différents d'un essai à l'autre.Chez l'enfant, l'effet est plus constant. Une méta-analyse portant sur 23 essais et plus de 6 000 enfants montre une réduction d'environ 11 % du risque d'avoir au moins un épisode respiratoire sur l'hiver, ainsi qu'une légère diminution du nombre de jours malades et des absences scolaires. En revanche, la durée de chaque épisode individuel ne diminue pas toujours.Certaines souches sont particulièrement étudiées. Lacticaseibacillus rhamnosus GG (LGG), par exemple, fait l'objet d'une revue systématique récente montrant une réduction modeste mais significative du nombre d'infections respiratoires, surtout chez les enfants ou les personnes sujettes aux rhumes fréquents. L'effet reste faible, mais reproductible.Chez l'adulte en bonne santé, les résultats sont plus variables. Un essai sur des employés de bureau consommant quotidiennement Lactobacillus casei Shirota a montré un net avantage : 22 % d'infections dans le groupe probiotique contre 53 % dans le groupe placebo. Mais d'autres essais, avec d'autres souches, ne retrouvent aucun effet, ce qui empêche de conclure de manière générale.En résumé : les probiotiques peuvent modestement réduire le nombre de rhumes et parfois leur durée, mais l'effet dépend fortement de la souche, de la dose et de la durée de consommation. Chez l'adulte, le bénéfice reste incertain ; chez l'enfant, il est plus probable. Dans tous les cas, ils ne remplacent ni le sommeil, ni l'hygiène, ni les mesures préventives classiques, mais peuvent être envisagés comme un petit complément, à condition de choisir des souches bien étudiées. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Today, I'm joined by the innovative Jon Hacker, whose name couldn't be more perfect for the biohacking space. While his family hacks computers, Jon decided to hack something a bit messier—the human mind. After growing up with severe OCD and witnessing the rising tide of global anxiety, he became obsessed with one question: Why are we all stuck in fight or flight, and what can we actually do about it?   Use code NAT at https://zenbud.health/nat for 20% off   Episode Timestamps: Introduction to Longevity Podcast and Host ... 00:00:00 The Rise of Anxiety and Mental Health Innovation ... 00:05:19 Why Modern Society Fuels Anxiety ... 00:07:18 Impact of Chronic Stress on Health ... 00:08:51 Barriers to Managing Anxiety with Habits Alone ... 00:17:17 CBT and the Need for Better Tools ... 00:19:27 Vagus Nerve: What It Does and Why It Matters ... 00:20:37 Zenbud: Ultrasound vs. Electrical Stimulation ... 00:28:58 Zenbud Headset Experience and Simplicity ... 00:34:25 Zenbud's Role in Stress Resilience and Longevity ... 00:47:45 Purpose, Mindfulness, and the Future of Biohacking ... 00:50:55 Zenbud: Key Safety Points and Adoption Challenges ... 01:01:08 Zenbud as "An Off Switch for Stress" and Closing ... 01:02:52 Final Tips, Special Offer, and Outro ... 01:03:30   Our Amazing Sponsors: Sunlamp (BTS2) by Mitolux - When your skin makes vitamin D from UVB light, it also creates natural companion molecules that help your body use it smarter—so you're not just boosting levels, you're activating your biology the way nature intended. Visit mitolux.com/NAT10. You'll receive 10% off! NAT10 will be automatically applied at checkout.   NEW Timeline Gummies: Urolithin A supports muscle strength and cellular energy. It's about improving how your body functions at the source. Mitopure is the only clinically proven Urolithin A, giving you six times more than you'd get from a glass of pomegranate juice. Visit Timeline.com/nat20 and use code nat20 for 20% off your purchase.   Probiotic Breakthrough by Bioptimizers - uses a stress-tested Lactobacillus plantarum strain that showed over 30× greater survival in bile and intestinal fluid vs. generic strains. Save 15% at bioptimizers.com/bionat and use code BIONAT for 15% off any order.   Nat's Links:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Today, I'm joined by the inspiring Dr. Darshan Shah, a board-certified surgeon who made the bold leap from the operating room to the forefront of longevity and functional medicine. In our conversation, Dr. Shah opens up about his own journey through burnout, chronic illness, and autoimmune disease, and shares how simple, consistent lifestyle changes became the real medicine that transformed his health. His experience revealed firsthand just how powerful habits like movement, proper nutrition, and sleep can be—often succeeding where surgery and prescriptions fell short.   Episode Timestamps: Intro and offers ... 00:00:00 Dr. Darshan Shah's journey from surgery to lifestyle medicine ... 00:04:37 Simple actions: nutrition, movement, habit formation ... 00:08:41 Challenges of doctors embracing lifestyle changes ... 00:11:06 Building a parallel system: prevention and chronic care ... 00:14:32 Empowering patients: tech, wearables, and AI ... 00:18:27 Therapeutic plasma exchange (TPE): mechanism and safety ... 00:27:47 Essential biomarker and at-home tests ... 00:48:19 Continuous glucose monitors and real-time health feedback ... 00:52:33 Next Health model: prevention, functional, lifestyle, longevity ... 00:43:08 Longevity circuit: cellular gym approach ... 00:59:37 Liquid biopsy and early cancer detection ... 01:02:08 Advice for health, self-care, and lifelong vitality ... 01:09:31 Where to learn more and clinic expansion ... 01:10:26   Our Amazing Sponsors: Manukora honey - From remote forests in New Zealand, where bees collect nectar from the native Manuka tea tree. That nectar is naturally rich in antibacterial compounds like MGO, plus antioxidants and prebiotics that support immunity and gut health. Visit manukora.com/NAT to save up to 31% plus $25 worth of free gifts with the Starter Kit - you'll get an MGO 850+ Manuka Honey jar, 5 travel sticks, a wooden spoon, and a guidebook. *Look out for their Black Friday/Cyber Monday promotion from 11/17/25 - 12/02/25..   Qualia NAD+ - A groundbreaking, doctor-formulated vegan formula that boosts your NAD levels by up to 67% for enhanced cellular energy, DNA repair, and detox support. Go to qualialife.com/NATHALIE  and use promo code NATHALIE to get 15% off—and try it risk-free with their 100-day money-back guarantee.   Probiotic Breakthrough by Bioptimizers - uses a stress-tested Lactobacillus plantarum strain that showed over 30× greater survival in bile and intestinal fluid vs. generic strains. Save 15% at bioptimizers.com/bionat and use code BIONAT for 15% off any order. Nat's Links:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Dr. Hoffman continues his conversation with Neil Levin, Senior Nutrition Education Manager and product formulator for Now Foods and Protocol for Life Balance.

Neil Levin, Senior Nutrition Education Manager and product formulator for Now Foods and Protocol for Life Balance, discusses the importance of targeted nutrients for women's health. They delve into various supplements such as magnesium, myo-inositol, progesterone cream, D-Mannose, and biotin, explaining their benefits for conditions like PCOS, blood sugar regulation, menstrual migraines, urinary tract infections, and overall skin, hair, and nail health. The conversation also touches on the importance of tailoring nutrients to individual needs and the role of personalized nutrition in supporting women's health amidst modern stresses.

Study: Mitopure's impact on immune parametersWhat important blood tests should one get, and what are the ideal levels to look for?I do coffee enemas for liver detox. How many can I do per week?  I've been on Metformin and lost some weight. Should I increase my dose to lose more?Could a recent dental implant be causing clogged ears and a hissing noise?

More on gadolinium effects and detoxI was found to have a small pericardial effusion. What advice can you give me?Is melatonin beneficial for bone mineral density? If so, how much should I take?

Today, I'm thrilled to welcome Dr. Amy Killen, a visionary in hormone optimization and regenerative medicine who is transforming the conversation around women's health and longevity. In this episode, Dr. Killen shares her personal journey—from witnessing her mother's struggle after a hip fracture, to becoming a steadfast advocate for correcting the myths and misinformation that still surround estrogen, progesterone, and testosterone optimization. Episode Timestamps: Ferritin, iron, and hormonal health basics ... 00:00:43 Dr. Amy Killen's evolving hormone focus ... 00:04:02 Women's Health Initiative and estrogen myths ... 00:06:31 Importance of hormone optimization vs. stem cells ... 00:10:25 Testosterone for women: symptoms, labs, delivery options ... 00:12:05 Side effects and nuances of testosterone therapy ... 00:14:01 SHBG, free testosterone, and lab variability ... 00:16:38 Libido, PT-141, and the biopsychosocial lens ... 00:21:46 Iron and ferritin: sweet spot and skin implications ... 00:29:16 Hot vs. HRT: definitions and individualization ... 00:34:23 Debunking estrogen and breast cancer myths ... 00:41:30 Aging expectations and finding the right doctor ... 00:43:18 Advice for women by decade—20s, 30s, 40s, etc. ... 00:47:20 Our Amazing Sponsors: Tro Zzz by Troscriptions - This isn't just melatonin—it's a powerhouse! Oblipair gives you honokiol and agarin to enhance GABA binding, while adenosine and cordycepin boost sleep drive and deep sleep. CBD, CBN, and 5‑HTP round it out. Head to troscriptions.com, use NAT10, and get 10% off your first order. NMN+G Rx by Wizard Sciences - A scientifically formulated blend of NMN, ginsenosides from Panax ginseng, and apigenin. Together, they enhance mitochondrial function, boost NAD+ levels, and support cellular repair. Go to wizardsciences.com and look for NMN+G. Use code NAT15 at checkout to get 15% off your purchase. Probiotic Breakthrough by Bioptimizers: uses a stress-tested Lactobacillus plantarum strain that showed over 30× greater survival in bile and intestinal fluid vs. generic strains. Save 15% at bioptimizers.com/bionat and use code BIONAT for 15% off any order. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Instagram Facebook Group

If you've ever walked out of a gynecology appointment still dealing with itching, burning, or a lingering sense that something's off—this conversation is for you. Most gynecologists still treat vaginal symptoms with a basic checklist: swab, prescribe, dismiss. But when those symptoms keep coming back, it's not a coincidence. It's a sign that the standard approach missed something important. On this episode of Medical Disruptors, I'm talking with Dr. Peggy Margetson—a women's health physician who doesn't just treat symptoms, she investigates. Together, they unpack why standard swabs often miss critical information about the vaginal microbiome, including collapsed Lactobacillus populations, hidden pathogens, and recurring pH imbalances that keep infections coming back. From there, the conversation moves into solutions. Dr. Peggy Margetson shares how her clinic uses targeted vaginal probiotics, treats partners when needed, and retests after treatment—not just to manage symptoms, but to confirm resolution. This is about real healing, not repeat prescriptions. If you've been handed the same antibiotic over and over while your symptoms keep returning—or if you've ever felt blamed instead of helped—this episode will give you the language and confidence to push back in the exam room. It's not about being a “difficult” patient. It's about refusing to accept half-answers when your body is asking better questions. Watch now to find out what your doctor isn't testing—and what you can do about it. Looking to schedule a consultation with Dr. E? Book here: drefratlamandre.com/consult Check us out on social media: drefratlamandre.com/instagram drefratlamandre.com/facebook drefratlamandre.com/tiktok #functionalmedicine #drefratlamandre #medicaldisruptor #NPwithaPHD #nursepractitioner #medicalgaslighting Chapters [00:00:00] Intro & mission [00:03:00] Founding her practice [00:14:00] Hidden causes of infection [00:21:00] Vaginal biome testing explained [00:32:00] Partner treatment & estrogen link Guest Links: FB: www.facebook.com/trustwomenshealthcare IG: www.instagram.com/trustwomenshealthcare YT: www.youtube.com/@drpeggynyc Website: www.trustwomenshealthcare.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Today, I'm diving solo into a topic that's both fascinating and a little bit spooky—senescent cells, also known as “zombie cells.” Understanding zombie cells is a crucial piece of the puzzle if you want to feel younger, stronger, and more resilient as you age. In this episode, I unpack what senescent cells are, why they're not just harmless bystanders, and how their buildup can accelerate the aging process and drive chronic inflammation—one of the hallmarks of aging. I break down the lifestyle habits that might be quietly increasing your zombie cell load, the early warning signs your body could be giving you, and most importantly, the evidence-backed interventions you can start using right now—from exercise and diet, to cutting-edge supplements, peptides, and more.   Episode Timestamps: What are Senescent (“Zombie”) Cells and Why They Matter ... 00:00:36 Key Causes and Lifestyle Factors Driving Senescence ... 00:02:40 Dietary Strategies: Mediterranean Diet, Protein, and Polyphenols ... 00:08:57 How Zombie Cells Disrupt Tissue and Drive Chronic Disease ... 00:13:37 Symptoms Linked to Excess Senescent Cells ... 00:20:58 Challenges in Measuring Senescent Cells ... 00:23:31 Senescent Cells: Helpful in Healing, Harmful in Excess ... 00:30:39 Senolytics and Senostatics: Drugs and Natural Compounds ... 00:36:14 Lifestyle and Supplement Strategies to Reduce Zombie Cells ... 00:39:14 Peptides for Advanced Senescence Management ... 00:48:09   Our Amazing Sponsors: Probiotic Breakthrough by Bioptimizers: uses a stress-tested Lactobacillus plantarum strain that showed over 30× greater survival in bile and intestinal fluid vs. generic strains. Save 15% at bioptimizers.com/bionat and use code BIONAT for 15% off any order.   Nat's Links:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

公園人多能互相安撫 最近是否吃飯配工作，三餐常常外食，擔心消化道機能嗎? 善存3效順暢益生菌，好消化、好代謝、給你青春好體質*！ 善存是70年大品牌，推出3效順暢益生菌，「雙專利益生菌、搭配鳳梨酵素」，３效助你養出消化道好環境#。專利代謝菌^，代謝順暢#，大大乾淨，一週養出六倍好菌^。專利青春菌，維持健康，人自然年輕。還有添加鳳梨酵素，水果風味酸甜好入口，面對外在挑戰, 由根本保護健康'！ 另外，善存還有舒眠益生菌，食品級植萃成份，擁有五大晚安因子：添加專利舒眠番紅花*、多國專利益生菌**、GABA***、芝麻素****、色胺酸等，可以幫助放鬆、好入睡！讓你天天吃好安心，想睡就睡、睡醒精神好^^! 好菌天天吃，養成青春好體質。投資財富靠自己，投資健康就讓善存來幫你！ 股癌限定隱藏優惠! 只要10/11-10/13到momo購買 3效順暢益生菌粉末顆粒，2入組直接給你85折! 主委加碼再送你一瓶克補! 舒眠益生菌10/13一日限定價~5入組$6279，再送SOU‧SOU聯名軟式珪藻土地墊 & 善存葉黃素正貨乙瓶唷! (活動詳情依momo網頁公告為主) https://www.momoshop.com.tw/goods/GoodsDetail.jsp?i_code=14456419 *青春美麗，調整體質 #改變細菌叢生態、維持消化道機能、調整體質 ^係指Lactobacillus paracasei、Bifidobacterium lactis、Lactobacillus plantarum之專利 ‘維持消化道機能, 維持健康 *植萃番紅花萃取物 **日本、中華民國、美國、中國 ***麩胺酸發酵物(含GABA) ****芝麻萃取物(含芝麻素) ^^晚上幫助入睡、白天精神旺盛 股癌傳送門：http://linktr.ee/gooaye -- Hosting provided by SoundOn

Do you know what Lactobacillus is? If you don't, I'm glad. Learn how to reposition an obstacle to help others have deeper understanding. #ThePitch #INICIVOX #VirtualMentorship

In this cheeky, confidence-boosting episode, our host shares all the spicy secrets to keeping your vagina fresh, fabulous, and oh-so-flavorful. The big sis advice we've all needed at some point- Jayna's answering the questions you might have been to shy to ask. (just wait till you hear what's wrong with all the feminine hygiene products you see at the supermarket!) From probiotics to pH balance, hydration to hygiene, we're dishing out the real talk your health class definitely skipped. So take a shot of tequila, then slide into your comfiest panties (organic cotton only, please), and get ready to laugh, learn, and love your taco a little more.

Dr. Hoffman continues his conversation with Martha Carlin, CEO and founder of the Bio Collective.

Martha Carlin, CEO and founder of the Bio Collective, details the significant influence of the microbiome on overall health. Martha discusses her unconventional path from accounting to microbiome research, sparked by her husband's Parkinson's diagnosis. Together, they explore the complex connections between gut health and diseases like Parkinson's, autism, and even Alzheimer's. Martha sheds light on groundbreaking research funded by NIH grants, the potential of machine learning and AI in understanding microbiome patterns, and the future prospects of personalized probiotics. Practical advice on maintaining a healthy microbiome, the impact of diet and exercise, and the intriguing intersections between gut health, neurochemistry, and systemic diseases are highlighted. The discussion also covers challenges in integrating microbiome research into clinical practice and potential future therapies.

TISS is a weekly podcast where Varun, Kautuk, Neville & Aadar discuss crazy "facts" they find on the internet. Come learn with them... or something like that.This week, the boys are diving into a hilarious episode of 'Thar Owners, Worst Holidays, & TV Trouble'To support TISS, check out our Instamojo: www.instamojo.com/@TISSOPFollow #TISS Shorts where we put out videos: https://bit.ly/3tUdLTCYou can also check out the podcast on Apple podcast, Spotify and Google podcast!https://shorturl.at/hfQZXhttp://apple.co/3neTO62http://spoti.fi/3blYG79http://bit.ly/3oh0BxkCheck out the TISS Sub-Reddit: https://bit.ly/2IEi0QsCheck out the TISS Discord: / discord Buy Varun Thakur's 420 Merch - http://bit.ly/2oDkhRVSubscribe To Our YT Channels:Varun - https://bit.ly/2HgGwqcAadar - https://bit.ly/37m49J2Kautuk - https://bit.ly/3jcpKGaNeville - https://bit.ly/2HfYlWyFollow Us on Instagram:Varun - / varunthakur Aadar - / theaadarguy Kautak - / cowtuk Neville - / nevilleshah. Ep 283 YouTube Chapters00:00 - Bawa's Apology01:19 - Bawa Not Coming Back Fully02:16 - Bawa Joining the Maa Kasam Tour04:22 - Bawa Does the Intro05:19 - Bawa's Bedbug Vacation11:13 - Bedbug Diving12:09 - Shark Facts13:23 - Sea Bugs Bite Bawa16:50 - What's Your Rashy?18:05 - Bitten by Siphonophores (and No Meds!)22:36 - Diving in Mumbai23:14 - ZNMD's Fake Diving Ads24:12 - Aadar Spent the Night at Glasgow Platform26:14 - Varun Sleeping at Muchhad Paanwala27:11 - Flying Paan27:51 - Muchhad Paanwala (Part 2)31:45 - Kautuk Slept on a Local Train32:21 - Bawa's Karjat Camp34:55 - The “Chai-Tea” Problem35:59 - Bawa Slept on the Train Floor37:28 - Kautuk Slept on the Beach with Dogs40:42 - Troubling Bawa42:43 - Betting on Bawa Simp Comments44:01 - Bawa's Unfulfilled Dream of a TV51:40 - Ikea Scam53:17 - Bawa Still Didn't Receive His TV54:58 - Varun's Wi-Fi55:47 - Bawa's Restaurant Recs56:40 - Lactobacillus, Curd & Jamalgota01:03:17 - The Flying Thar01:06:10 - “ReThar-ded” People01:08:43 - Qualis Kids and Driver01:10:45 - Figuring Out Japanese Cars01:11:54 - Korean Woman Failed Driving Test 900 Times01:16:38 - Thar Roast 2.001:17:45 - Bihari Road Digger01:18:25 - Bawa's Outro01:19:18 - Varun's Outro01:19:45 - Outro 2.0Thumbnail - Anjali Handa

Targeted probiotic strains improve endurance, strength, recovery, and mental resilience by supporting gut integrity, reducing inflammation, and enhancing nutrient absorption Intense training damages your gut lining and weakens immunity, but probiotics help maintain barrier function and prevent bacterial toxins from triggering systemic inflammation Specific strains deliver specific benefits, such as Lactobacillus plantarum for endurance, Bacillus coagulans for muscle recovery, and Lactobacillus casei for stress reduction Supporting butyrate-producing bacteria fuels intestinal cells, improves lipid metabolism, and enhances oxidative muscle fibers for sustained aerobic performance Probiotics are most effective when introduced after gut healing, paired with a diet free from linoleic acid–rich vegetable oils and supported by prebiotic foods to maintain microbial balance

Hello & Welcome To The Podcast!Today, I'm joined by Eleanor & Jess from PelvicRelief where we'll be discussing all things microbiome and pelvic health, in conditions like fertility, UTIs, and menopausal health. We also explored the role of diet, probiotics, and specific Lactobacillus strains in maintaining vaginal health, and the challenges of prescribing beneficial supplements, emphasizing the importance of accurate diagnosis and treatment. We discussed the challenges and distressing nature of recurrent UTIs and other vulvovaginal infections, emphasizing the need for effective & multi-modal solutions to manage these conditionsWe talked about the vaginal microbiome, emphasizing the importance of Lactobacillus dominance for maintaining an acidic environment, and explored common imbalances like bacterial vaginosis and yeast infections, and their potential impact on fertility and overall health. The conversation highlights the role of estrogen in maintaining vaginal health, particularly during peri-menopause and post-menopause. Jess and Eleanor stressed the importance of accurate diagnosis and treatment, cautioning against overuse of over-the-counter medications. The discussion also touches on the relationship between the bladder and vaginal microbiomes, and the impact of cancer treatments on vaginal health, and much more!For more info: make sure to visit pelvicrelief.co.uk and they are also on Instagram @pelvicrelief. I have much excitement about these products' potential to provide a more specific and bespoke approach to pelvic relief - looking forward to hearing more as the science continues to evolve!If you'd like to learn more about women's health, from back pain to bowel health, menstrual to menopausal health, pelvic pain and femalecentric oncology rehab - all of my online courses are available at https://celebratemuliebrity.com/Until next time, Onwards & Upwards! Mx #celebratemuliebrity.com

Amanda Lewis, Ph.D. investigates how glycan-degrading enzymes contribute to bacterial vaginosis (BV), a common condition linked to infertility, preterm birth, pelvic inflammatory disease, and increased cancer risk. Her research shows that BV-associated bacteria strip protective sugar coatings—glycans—from vaginal epithelial cells, disrupting normal function and increasing vulnerability to infection. Lewis and her team study specific enzymes, such as sialidases, that remove sialic acid from glycoproteins and mucins. Using clinical samples and imaging techniques, they identify how these changes in glycan composition correlate with disease severity. Their work reveals how glycan degradation contributes to persistent or recurrent BV and opens new pathways for understanding the microbiome's role in women's health. Series: "Motherhood Channel" [Health and Medicine] [Show ID: 40678]

TWiN discusses research showing that Lactobacillus acidophilus promotes cognitive function recovery after cerebral ischemia, by regulating microglial peroxisomal function. Hosts: Vincent Racaniello, Vivianne Morrison, and Tim Cheung Subscribe (free): Apple Podcasts, Google Podcasts, RSS Links for this episode MicrobeTV Discord Server Arc is pdb molecule of the month (PDB) Probiotics after stroke (Cell Host Microbe) Timestamps by Jolene Ramsey. Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@microbe.tv

Fiber, Polyphenols & Your Gut Microbiome: Part One Are you feeding the right microbes — or the wrong ones? In this episode of The Coach Debbie Potts Show, we're kicking off a new two-part deep dive into how fiber and polyphenols shape your gut microbiome, your metabolism, and your long-term health. Most of us have heard that “fiber is good for your gut,” but the truth is more nuanced. The type of fiber — and the type of gut you have — makes all the difference. For some, fiber can help feed beneficial bacteria that support digestion, immunity, and brain health. For others, especially those struggling with SIBO, IBS, or candida overgrowth, the wrong kind of fiber can worsen bloating, gas, or inflammation. That's where polyphenols come in — the colorful plant compounds found in berries, green tea, cocoa, and pomegranate. These act as a gentler “fertilizer” for beneficial microbes like Bifidobacteria and Lactobacillus, while helping keep harmful bacteria in check. In Part One, we'll cover: ✅ The difference between fibers and polyphenols in gut health ✅ Why your gut type determines your response to fiber ✅ How polyphenols can help reduce toxins like LPS (endotoxins) that drive inflammation ✅ Practical food swaps to support a healthier, more resilient microbiome By the end of this episode, you'll understand why one-size-fits-all fiber advice doesn't work — and how you can use food color and polyphenols to start healing your gut from the inside out.

There's a powerful story behind the creamy, tangy yogurt that originated in the mountains of Bulgaria. In this episode, I'll share the fascinating legend of how Bulgarian yogurt healed a king, the science that won a Nobel Prize, and the probiotic strains—like Lactobacillus bulgaricus—that make this yogurt one of the most healing fermented foods you can eat. I'll also explain how you can make it at home with my favorite starters, and why it's become a daily staple in my kitchen (and heart). Episode link:  https://www.culturedfoodlife.com/podcast/episode-325-bulgarian-yogurt-the-ancient-culture-that-changed-everything/ Link(s) I talked about: Article: https://www.culturedfoodlife.com/bulgarian-yogurt-the-ancient-culture-that-changed-everything/ Check out these other links: My Story Video: https://youtu.be/CbX9Nv9OtGM For health tips and recipes, subscribe to our weekly emails. We'll also send you our free Getting Started Guide: http://bit.ly/2BnHpay Listen to all my podcasts: http://bit.ly/cflpodcast Become a Biotic Pro Member: http://bit.ly/2kkhwS1 Cultured Food Recipes: http://bit.ly/2UIfY2x Health and Food Topics: http://bit.ly/2SdzIOS My Amazon Shop: https://bit.ly/3KdhEge MY STARTER CULTURES Milk Kefir Grains: http://bit.ly/2rQ99PE L. Reuteri Superfood: https://bit.ly/LReuteriSuperfoodStarter L. Gasseri Superfood: https://bit.ly/LGasseriSuperfoodStarter Easy Kefir: http://bit.ly/2MQ1nPV Kefir Soda Starter: http://bit.ly/3YVErTa Kombucha Starter: http://bit.ly/2g2R9hE Vegetable Starter: http://bit.ly/2SzzVem Water Kefir Crystals:  http://bit.ly/2irmImW Sourdough Starter: http://bit.ly/2IjaaXK Other items in my store: http://bit.ly/2HTKZ27 STAY CONNECTED Instagram: http://instagram.com/culturedfoodlife/ Facebook: https://www.facebook.com/CulturedFoodLife/ Pinterest: http://pinterest.com/donnaschwenk/ Twitter: https://twitter.com/donnaschwenk

Welcome back to our weekend Cabral HouseCall shows! This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track! Check out today's questions:    Trish: Hi Dr. Cabral - I'm a 55-year-old female working on lowering overall inflammation in my body. My CRP levels are (4.1), ApoB (118 nmol/L and Lipoprotein (A) (281 nmol/L) as you can see are high. Total Cholesterol 221 and Triglycerides are 70. I have a lot of stiffness with joint discomfort. I started taking 2 Proteolytic Enzymes upon waking. Then your DNS, D3/k2, Cell Boost, Inflamma Soothe, Collagen with GLP Tone System and some of your other products (eye and hair). I follow your Med diet. My pain and stiffness have improved ALOT in a matter of days. I'm going to retest my CRP and chol levels in 4 months. My question is how long can I take Proteolytic Enzymes and in your opinion am I taking the proper protocol for these issues? I'm retesting in 4 mos. Thank you in advance          Sheena: Hi Dr Cabral! Hope you and all of your health family are well. I'm a surgical Processor and on my feet all day. I've tried all kinds of compression socks but by the end of the day, after taking it off, my leg are soo itchy! I scratch it sometimes so bad it starts to bleed. I'm only wearing the average 15-20 mmHG so its not too tight. I'm curious if you have a recommendation for compression socks that wont causes itching but is effective? Thanks in advance for answering!      Christina: Stephen, I have listened on one of your podcasts about Rheumatoid Arthritis and detoxing. My mother is in her early 70s and her fingers are twisting. I am 48 and recently the base of my thumbs have started bothering me. My question is, what detox protocol should my mother start with to prevent further twisting of her fingers and what detox protocol should I do to prevent this from happening to me? I would love to do the heavy metals and organic acid tests, but unfortunately I live in NY. Would my functional medicine doctor be able to order them for me? I have had HELLP, HUS, DIC, Guillian Barre, and Pulminary Edema in my pregnancy at 21. My son was delivered with no issues! At this time, we learned that I have ITTP. I have had IBS issues. Thank you, Christina                      Ryan: Hi dr cabral, Im a 29 year old male who has addisons disease, chronic post nasal drip, food intolerance's and teeth grinding a stool test confirmed klebsiella pneumonie overgrowth and blastocystis hominis as well as some yeast and fungus with no Bifidobacteria and Lactobacillus detected, I recently started the cbo protocol with citricidal drops im 7 days in untill i came across one of your videos where you mentioned you should go for the parasite first should i stop the cbo protocol and start the para support protocol and then continue the cbo after or just continue the cbo protocol Thank you for your time wishing you all the best ryan.                                                                                                                                     Kay: Hi Dr. Cabral, I I love your podcasts and look forward to them every week. Anyway, I was wondering if you could please explain how a traumatic event could spur the onset of a "dis-ease" such as asthma. My daughter's asthma began shortly after her father and I were separated and he moved out of state. According to her pediatrician at the time, she was "more prone to having asthma because she also had eczema." This was 2 decades ago, and now she's 31 and we know more about autoimmune issues. Although she continues to carry an inhaler with her, she hardly needs to use it anymore. What would you recommend for a more root cause approach to someone with her condition? Thank you.                                  Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community's questions!    - - - Show Notes and Resources: StephenCabral.com/3466 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Dr. Mark Pimentel, Executive Director of the MAST program at Cedars-Sinai in Los Angeles, shares groundbreaking insights into the small intestinal microbiome that challenge long-held beliefs about gut bacteria. Findings from his team's REIMAGINE study reveal that the small intestine is far from sterile, as previously thought—instead, it harbors substantial bacterial communities that play a critical role in health and disease, especially in conditions such as IBS and SIBO.• E. coli and Klebsiella act as aggressive "Ferrari" bacteria that outcompete other microbes and destroy microbial diversity when overgrown inducing a "apocalyptic" disruption of the small bowel microbiome.• Lactobacillus, commonly found in many probiotics, may act as a disruptor in the small intestine and new research correlates higher small intestinal levels with obesity and unhealthy aging (more research needed)• The PLACIDE trial found probiotics didn't reduce C. diff or antibiotic-associated diarrhea but did increase bloating• Food poisoning is the only proven cause-and-effect trigger for IBS, with stress acting as a modifier rather than initiator• Combining rifaximin with NAC works 10x better for SIBO by targeting bacteria in both intestinal fluid and mucus• A new compound (CS06) shows promise for reducing methane production and relieving constipation• Three distinct gas patterns (hydrogen, methane, hydrogen sulfide) correlate with different symptom patterns and respond to targeted treatmentsThis episode was sponsored by Salix Pharmaceuticals. Resources: DDW 2025 Abstracts by the Mast Program and Dr. PimentelA Novel Microbiome Therapy, CS-06 (MTD Blocker), Reduces Methane Production in Stool CultureReal World Study of Three-Gas Breath Testing Nationwide and The Association with SymptomsLearn more about Kate and Dr. Riehl:Website: www.katescarlata.com and www.drriehl.comInstagram: @katescarlata @drriehl and @theguthealthpodcastOrder Kate and Dr. Riehl's book, Mind Your Gut: The Science-Based, Whole-body Guide to Living Well with IBS. The information included in this podcast is not a substitute for professional medical advice, examination, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider before starting any new treatment or making changes to existing treatment.

In this episode, Lyell K. Jones Jr, MD, FAAN, speaks with Michael S. Okun, MD, FAAN, who served as the guest editor of the August 2025 Movement Disorders issue. They provide a preview of the issue, which publishes on August 1, 2025. Dr. Jones is the editor-in-chief of Continuum: Lifelong Learning in Neurology® and is a professor of neurology at Mayo Clinic in Rochester, Minnesota. Dr. Okun is the director at Norman Fixel Institute for Neurological Diseases and distinguished professor of neurology at University of Florida in Gainesville, Florida. Additional Resources Read the issue: continuum.aan.com Subscribe to Continuum®: shop.lww.com/Continuum Continuum® Aloud (verbatim audio-book style recordings of articles available only to Continuum® subscribers): continpub.com/Aloud More about the American Academy of Neurology: aan.com Social Media facebook.com/continuumcme @ContinuumAAN Host: @LyellJ Guest: @MichaelOkun Full episode transcript available here: Dr Jones: Our ability to move through the world is one of the essential functions of our nervous system. Gross movements like walking ranging down to fine movements with our eyes and our hands, our ability to create and coordinate movement is something many of us take for granted. So what do we do when those movements stop working as we intend? Today I have the opportunity to speak with one of the world's leading experts on movement disorders, Dr Michael Okun, about the latest issue of Continuum on Movement Disorders. Dr Jones: This is Dr Lyell Jones, Editor-in-Chief of Continuum. Thank you for listening to Continuum Audio. Be sure to visit the links in the episode notes for information about subscribing to the journal, listening to verbatim recordings of the articles, and exclusive access to interviews not featured on the podcast. Dr Jones: This is Dr Lyle Jones, Editor-in-Chief of Continuum: Lifelong Learning in Neurology. Today, I'm interviewing Dr Michael Okun, who is Continuum's guest editor for our latest issue on movement disorders. Dr Okun is the Adelaide Lackner Distinguished Professor of Neurology at the University of Florida in Gainesville, where he's also the director of the Norman Fixel Institute for Neurological Diseases. Dr Okun, welcome, and thank you for joining us today. Why don't you introduce yourselves to our listeners?  Dr Okun: It's great to be here today. And I'm a neurologist. Everybody who knows me knows I'm pretty simple. I believe the patient's the sun and we should always orbit around the person with disease, and so that's how I look at my practice. And I know we always participate in a lot of research, and I've got a research lab and all those things. But to me, it's always the patients and the families first. So, it'll be great to have that discussion today.  Dr Jones: Yeah, thank you for that, Dr Oaken. Obviously, movement disorders is a huge part of our field of neurology. There are many highly prevalent conditions that fit into this category that most of our listeners will be familiar with: idiopathic Parkinson's disease, essential tremor, tic disorders and so on. And having worked with trainees for a long time, it's one of the areas that I see a lot of trainees gravitate to movement disorders. And I think it's in part because of the prevalence; I think it's in part because of the diversity of the specialty with treatment options and DBS and Botox. But it's also the centrality of the neurologic exam, right? That's- the clinical examination of the patient is so fundamental. And we'll cover a lot of topics today with some questions that I have for you about biomarkers and new developments in the field. But is that your sense too, that people are drawn to just the old-fashioned, essential focus on the neurologic encounter and the neurologic exam? Dr Okun: I believe that is one of the draws to the field of movement. I think that you have neurologists from all over the world that are really interested and fascinated with what things look like. And when you see something that's a little bit, you know, off the normal road or off the normal beaten path… and we are always curious. And so, I got into movement disorders, I think, accidentally; I think even as a child, I was looking at people who had abnormal movements and tremors and I was very fascinated as to why those things happened and what's going on in the brain. And, you know, what are the symptoms and the signs. And then later on, even as my own career developed, that black bag was so great as a neurologist. I mean, it makes us so much more powerful than any of the other clinicians---at least in my biased opinion---out on the wards and out in the clinic. And, you know, knowing the signs and the symptoms, knowing how to do a neurological examination and really walking through the phenomenology, what people look like, you know, which is different than the geno- you know, the genotypes, what the genes are. What people look like is so much more important as clinicians. And so, I think that movement disorders is just the specialty for that, at least in my opinion. Dr Jones: And it helps bring it back to the patient. And that's something that I saw coming through the articles in this issue. And let's get right to it. You've had a chance to review all these articles on all these different topics across the entire field of movement disorders. As you look at that survey of the field, Dr Okun, what do you think is the most exciting recent development for patients with movement disorders?  Dr Okun: I think that when you look across all of the different specialties, what you're seeing is a shift. And the shift is that, you know, a lot of people used to talk in our generation about neurology being one of these “diagnose and adios” specialties. You make the diagnosis and there's nothing that you can do, you know, about these diseases. And boy, that has changed. I mean, we have really blown it out of the water. And when you look at the topics and what people are writing about now and the Continuum issue, and we compare that the last several Continuum issues on movement disorders, we just keep accumulating a knowledge base about what these things look like and how we can treat them. And when we start thinking about, you know, all of the emergence of the autoimmune disorders and identifying the right one and getting something that's quite treatable. Back in my day, and in your day, Lyle, we saw these things and we didn't know what they were. And now we have antibodies, now we can identify them, we can pin them down, and we can treat many of them and really change people's lives. And so, I'm really impressed at what I see in changes in identification of autoimmune disorders, of channelopathies and some of the more rare things, but I'm also impressed with just the fundamental principles of how we're teaching people to be better clinicians in diseases like Parkinson's, Huntington's, ataxia, and Tourette. And so, my enthusiasm for this issue of Continuum is both on, you know, the cutting edge of what we're seeing based on the identification on our exams, what we can do for these people, but also the emergence of how we're shifting and providing much better care across a continuum for folks with basal ganglia diseases. Dr Jones: Yeah, I appreciate that perspective, Dr Okun. One of the common themes that I saw in the issue was with these new developments, right, when you have new tools like new diagnostic biomarker tools, is the question of if and when and how to integrate those into daily clinical practice, right? So, we've had imaging biomarkers for a while, DAT scans, etc. For patients with idiopathic Parkinson disease, one of the things that I hear a lot of discussion and controversy about are the seed amplification assays as diagnostic biomarkers. What can you tell us about those? Are those ready for routine clinical use yet?  Dr Okun: I think the main bottom-line point for folks that are out there trying to practice neurology, either in general clinics or even in specialty clinics, is to know that there is this movement toward, can we biologically classify a disease? One of the things that has, you know, really accelerated that effort has been the development of these seed amplification assays, which---in short for people who are listening---are basically, we “shake and bake” these things. You know? We shake them for like 20 hours and we use these prionlike proteins, and we learn from diseases like prion disease how to kind of tag these things and then see, do they have degenerative properties? And in the case of Parkinson's disease, we're able to do this with synuclein. That is the idea of a seed amplification assay. We're able to use this to see, hey, is there synuclein present or not in this sample? And people are looking at things like cerebrospinal fluid, they're looking at things like blood and saliva, and they're finding it. The challenge here is that, remember- and one of the things that's great about this issue of Continuum is, remember, there are a whole bunch of different synucleinopathies. So, Dr Jones, it isn't just Parkinson's disease. So, you've got Parkinson's disease, you've got Lewy body, you know, and dementia with Lewy bodies. You've got, you know, multiple system atrophy is within that synucleinopathy, you know, group primary autonomic failure… so not just Parkinson's disease. And so, I think we have to tap the brakes as clinicians and just say, we are where we are. We are moving in that direction. And remember that a seed amplification assay gives you some information, but it doesn't give you all the information. It doesn't forgive you looking at a person over time, examining them in your clinic, seeing how they progress, seeing their response to dopamine- and by the way, several of these genes that are associated with Parkinson; and there's, you know, less than 20% of Parkinson is genetic, but several of these genes, in a solid third---and in some cases, in some series, even more---miss the synuclein assay, misses, you know, the presence of a disease like Parkinson's disease. And so, we have to be careful in how we interpret it. And I think we're more likely to see over time a gemish: we're going to smush together all this information. We're going to get better with MRIs. And so, we're actually doing much better with MRIs and AI-based intelligence. We've got DAT scans, we've got synuclein assays. But more than anything, everybody listening out there, you can still examine the person and examine them over time and see how they do over time and see how they do with dopamine. And that is still a really, really solid way to do this. The synuclein assays are probably going to be ready for prime time more in choosing and enriching clinical trials populations first. And you know, we're probably 5, 10 years behind where Alzheimer's is right now. So, we'll get there at some point, but it's not going to be a silver bullet. I think we're looking at these are going to be things that are going to be interpreted in the context for a clinician of our examination and in the context of where the field is and what you're trying to use the information for. Dr Jones: Thank you for that. And I think that's the general gestalt I got from the articles and what I hear from my colleagues. And I think we've seen this in other domains of neurology, right? We have the specificity and sensitivity issues with the biomarkers, but we also have the high prevalence of copathology, right? People can have multiple different neurodegenerative problems, and I think it gets back to that clinical context, like you said, following the patient longitudinally. That was a theme that came out in the idiopathic Parkinson disease article. And while we're on Parkinson disease, you know, the first description of that was what, more than two hundred years ago. And I think we're still thinking about the pathophysiology of that disorder. We understand risk factors, and I think many of our listeners would be familiar with those. But as far as the actual cause, you know, there's been discussion in recent years about, is there a role of the gut microbiome? Is this a prionopathic disorder? What's your take on all of that?  Dr Okun: Yeah, so it's a great question. It's a super-hot area right now of Parkinson. And I kind of take this, you know, apart in a couple of different ways. First of all, when we think about Parkinson disease, we have to think upstream. Like, what are the cause and causes? Okay? So, Parkinson is not one disease, okay? And even within the genes, there's a bunch of different genes that cause it. But then we have to look and say, well, if that's less than 20% depending on who's counting, then 80% don't have a single piece of DNA that's closely associated with this syndrome. And so, what are we missing with environment and other factors? We need to understand not what happens at the end of the process, not necessarily when synuclein is clumping- and by the way, there's a lot of synuclein in the brains normally, and there's a lot of Tau in people's brains who have Parkinson as well. We don't know what we don't know, Dr Jones. And so when we begin to think about this disease, we've got to look upstream. We've got to start to think, where do things really start? Okay? We've got to stop looking at it as probably a single disease or disorder, and it's a circuit disorder. And then as we begin to develop and follow people along that pathway and continuum, we're going to realize that it's not a one-size-fits-all equation when we're trying to look at Parkinson. By the way, for people listening, we only spend two to three cents out of every dollar on prevention. Wouldn't prevention be the best cure, right? Like, if we were thinking about this disease. And so that's something that we should be, you know, thinking about. And then the other is the Global Burden of Disease study. You know, when we wrote about this in a book called Ending Parkinson's Disease, it looked like Parkinson's was going to double by 2035. The new numbers tell us it's almost double to the level that we expected in 2035 in this last series of numbers. So, it's actually growing much faster. We have to ask why? Why is it growing faster? And then we have lots of folks, and even within these issues here within Continuum, people are beginning to talk about maybe these environmental things that might be blind spots. Is it starting in our nose? Is it starting in our gut? And then we get to the gut question. And the gut question is, if we look at the microbiomes of people with Parkinson, there does seem to be, in a group of folks with Parkinson, a Parkinson microbiome. Not in everyone, but if you look at it in composite, there seems to be some clues there. We see changes in Lactobacillus, we see some bacteria going up that are good, some bacteria going down, you know, that are bad. And we see flipping around, and that can change as we put people on probiotics and we try to do fecal microbiota transplantations- which, by the way, the data so far has not been positive in Parkinson's. Doesn't mean we might not get there at some point, but I think the main point here is that as we move into the AI generation, there are just millions and millions and millions of organisms within your gut. And it's going to take more than just our eyes and just our regular arithmetic. You and I probably know how to do arithmetic really well, but this is, like, going to be a much bigger problem for computers that are way smarter than our brains to start to look and say, well, we see the bacteria is up here. That's a good bacteria, that's a good thing or it's down with this bacteria or this phage or there's a relationship or proportion that's changing. And so, we're not quite there. And so, I always tell people---and you know, we talk about the sum in the issue---microbiomes aren't quite ready for prime time yet. And so be careful, because you could tweak the system and you might actually end up worse than before you started. So, we don't know what we don't know on this issue.  Dr Jones: And that's a great point. And one of the themes they're reading between the lines is, we will continue to work on understanding the bio-pathophysiology, but we can't wait until that day to start managing the risk factors and treating patients, which I think is a good point. And if we pivot to treatment here a little bit, you know, one of the exciting areas of movement disorders---and really neurology broadly, I think movement disorders has led the field in many ways---is bioelectronic therapy, or what one of my colleagues taught me is “electroceutical therapy”, which I think is a wonderful term. Dr Okun, when our listeners are hearing about the latest in deep brain stimulation in patients who have movement disorders, what should they know? What are the latest developments in that area with devices? Dr Okun: Yeah. So, they should know that things are moving rapidly in the field of putting electricity into the brain. And we're way past the era where we thought putting a little bit of electricity was snake oil. We know we can actually drive these circuits, and we know that many of these disorders---and actually, probably all of the disorders within this issue of Continuum---are all circuit disorders. And so, you can drive the circuit by modulating the circuit. And it's turned out to be quite robust with therapies like deep brain stimulation. Now, we're seeing uses of deep brain stimulation across multiple of these disorders now. So, for example, you may think of it in Parkinson's disease, but now we're also seeing people use it to help in cases where you need to palliate very severe and bothersome chorea and Huntington's disease, we're seeing it move along in Tourette syndrome. We of course have seen this for various hyperkinetic disorders and dystonias. And so, the main thing for clinicians to realize when dealing with neuromodulation is, take a deep breath because it can be overwhelming. We have a lot of different devices in the marketplace and no matter how many different devices we have in the marketplace, the most important thing is that we get the leads. You know, where we're stimulating into the right location. It's like real estate: location, location, location, whether you've got a lead that can steer left, right, up, down and do all of these things. Second, if you're feeling overwhelmed because there are so many devices and so many settings, especially as we put these leads in and they have all sorts of different, you know, nodes on them and you can steer this way and that way, you are not alone. Everybody is feeling that way now. And we're beginning to see AI solutions to that that are going to merge together with imaging, and then we're moving toward an era of, you know, should I say things like robotic programming, where it's going to be actually so complicated as we move forward that we're going to have to automate these systems. There's no way to get this and scale this for all of the locales within the United States, but within the entire world of people that need these types of devices and these therapies. And so, it's moving rapidly. It's overwhelming. The most important thing is choosing the right person. Okay? For this, with multidisciplinary teams, getting the lead in the right place. And then all these other little bells and whistles, they're like sculpting. So, if you think of a sculpture, you kind of get that sculpture almost there. You know, those little adds are helping to maybe make the eyes come out a little more or the facial expression a little bit better. There's little bits of sculpting. But if you're feeling overwhelmed by it, everybody is. And then also remember that we're starting to move towards some trials here that are in their early stages. And a lot of times when we start, we need more failures to get to our successes. So, we're seeing trials of people looking at, like, oligo therapies and protein therapies. We're seeing CRISPR gene therapies in the laboratory. And we should have a zero tolerance for errors with CRISPR, okay? we still have issues with CRISPR in the laboratory and which ones we apply it to and with animals. But it's still pretty exciting when we're starting to see some of these therapies move forward. We're going to see gene therapies, and then the other thing we're going to see are nano-therapies. And remember, smaller can be better. It can slip across the blood brain barrier, you have very good surface area-to-volume ratios, and we can uncage drugs by shining things like focused ultrasound beams or magnets or heat onto these particles to turn them on or off. And so, we're seeing a great change in the field there. And then also, I should mention: pumps are coming and they're here. We're getting pumps like we have for diabetes and neurology. It's very exciting. It's going to be overwhelming as everybody tries to learn how to do this. So again, if you're feeling overwhelmed, so am I. Okay? But you know, pumps underneath the skin for dopamine, pumps underneath the skin for apomorphine. And that may apply to other disorders and not just Parkinson as we move along, what we put into those therapies. So, we're seeing that age come forward. And then making lesions from outside the brain with focused ultrasound, we're starting to get better at that. Precision is less coming from outside the brain; complications are also less. And as we learn how to do that better, that also can provide more options for folks. So, a lot of things to read about in this issue of Continuum and a lot of really interesting and beyond, I would say, you know, the horizon as to where we're headed.  Dr Jones: Thank you for that. And it is a lot. It can be overwhelming, which I guess is maybe a good reason to read the issue, right? I think that's a great place to end and encourage our listeners to pick up the issue. And Dr Okun, I want to thank you for joining us today. Thank you for such a great discussion on movement disorders. I learned a lot. I'm sure our listeners will as well, given the importance of the topic, your leadership in the field over many years. I'm grateful that you have put this issue together. So, thank you. And you're a busy person. I don't know how we talked you into doing this, but I'm really glad that we did.  Dr Okun: Well, it's been my honor. And I just want to point out that the whole authorship panel that agreed to write these articles, they did all the work. I'm just a talking head here, you know, telling you what they did, but they're writing, and the people that are in the field are really, you know, leading and helping us to understand, and have really put it together in a way that's kind of helped us to be better clinicians and to impact more lives. So, I want to thank the group of authors, and thank you, Dr Jones. Dr Jones: Again, we've been speaking with Dr Michael Okun, guest editor of Continuum's most recent issue on movement disorders. Please check it out. And thank you to our listeners for joining today. Dr Monteith: This is Dr Teshamae Monteith, Associate Editor of Continuum Audio. If you've enjoyed this episode, you'll love the journal, which is full of in-depth and clinically relevant information important for neurology practitioners. Use the link in the episode notes to learn more and subscribe. Thank you for listening to Continuum Audio.

We're diving into the top functional and conventional tests to consider after the second trimester or late pregnancy loss, especially if you've been diagnosed with low AMH, high FSH, diminished ovarian reserve (DOR), or premature ovarian insufficiency (POI). If you've had a second trimester loss or late pregnancy loss after 20 weeks and been told “everything looks normal,”this episode is for you. We dive into what's often overlooked in conventional care and how a functional fertility approach can help uncover underlying imbalances that impact conception, hormone health, and pregnancy outcomes. In this episode we cover 7 categories of testing to consider after late loss especially if you have low AMH, diminished ovarian reserve, autoimmune issues, recurrent miscarriage, or unexplained infertility. You'll learn: The top clotting and thrombophilia markers to test (including Factor V Leiden and antiphospholipid antibodies) Which inflammatory and immune markers (hs-CRP, ANA, cytokines, NK cells) are often missed and why they matter How the vaginal microbiome and hidden infections like ureaplasma can cause second-trimester loss The role of chronic stress, adrenal hormones and the HPA axis in pregnancy outcomes Why a comprehensive blood chemistry panel can reveal nutrient deficiencies and hormone imbalances that are missed by conventional labs Key methylation and genetic SNPs (like MTHFR) that impact detoxification, clotting and hormone metabolism The impact of gut health and stool testing on immune tolerance, estrogen balance and inflammation We'll also explain how this whole body functional lens can guide your next steps in preconception planning, whether you're trying again naturally or preparing for IVF. This episode is for you if: You've experienced a loss after 14 weeks of pregnancy and are seeking deeper understanding and support. You want to explore both conventional and functional medicine approaches to uncover underlying causes. You're looking for practical lifestyle, testing, and healing strategies to improve future pregnancy outcomes. --- TIMESTAMPS [00:00:00] Introduction: Late term pregnancy loss overview, compassion, and what to expect in this episode [00:02:30] Functional fertility testing for late term loss thrombophilia panel, immune markers, inflammation, and infections [00:06:00] Stress hormones, nervous system support, and comprehensive blood chemistry for improving pregnancy outcomes [00:09:00] Blood sugar, insulin, and comprehensive thyroid testing in pregnancy loss [00:12:00] Genetic testing, including MTHFR mutations and the importance of body healing before conception [00:14:30] Role of gut health, infections, and estrogen metabolism in pregnancy loss --- RESOURCES

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