The composite of the organism's observable characteristics or traits
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In this Twilight Zone-inspired episode of BioTA, two biology students prepping for lab encounter a pair of unexpected space travelers who want help unraveling a mystery: Why do some bacteria defy antibiotics while others perish? Why do some plants tolerate herbicides while others shrivel? With a crash course in the concepts of genotypes and phenotypes, the students explain some of the basic principles that life on Earth follows (most of the time).
Join us for another NeuroNoodle Neurofeedback Podcast episode featuring Jay Gunkelman, QEEGD (the man who has read over 500,000 brain scans) and Dr. Mari Swingle (author of i-Minds). Hosted by Pete Jansons, this episode dives into the controversy around unlicensed life coaches, the role of neurofeedback in mental health, and why executive coaching could benefit from EEG scans. ✅ Topics Discussed: ✅ Should life coaches be licensed to discuss mental health? ✅ The dangers of unregulated mental health coaching ✅ How neurofeedback can optimize brain function ✅ What EEGs reveal about procrastination and motivation ✅ The role of TMS (Transcranial Magnetic Stimulation) in mental health treatment ✅ How executive coaching could benefit from brain scans ⏱️ Key Moments: ✅ 0:00 Show Start ✅ 0:24 Bill aims to prevent unlicensed life coaches from practicing mental health therapy
DOI: 10.13056/acamh.13668 In this Papers Podcast, Dr. Franjo Ivankovic discusses their co-authored JCPP paper ‘Optimization of self- or parent-reported psychiatric phenotypes in longitudinal studies'. There is an overview of the paper, methodology, key findings, and implications for practice. Learning Objectives 1. The reliability and validity of consistent self-endorsement of a given psychiatric diagnosis. 2. Insight into the low agreement between parent-reported, child-reported, and clinician reported psychiatric phenotypes and why these different informants might report different levels of mental health difficulties when the target child is the same. 3. The over-endorsement and under-endorsement of symptoms of mental health difficulties when self-reporting and the impact on the prevalence of mental health conditions. 4. Insight into the Adolescent Brain Cognitive Development (ABCD) study and the narrow diagnosis construct. 5. Whether there is evidence of a relationship between the over-endorsement of symptoms of mental health conditions and a high level of public awareness of the symptoms of those conditions. 6. The implications of this study for other researchers and to what extent over-endorsement is a problem across the board in cohort studies and population level investigations, as well as recommendations moving forward.
Send us a textPatent Ductus Arteriosus and Lung Magnetic Resonance Imaging Phenotype in Moderate and Severe Bronchopulmonary Dysplasia-Pulmonary Hypertension.Bjorkman KR, Miles KG, Bellew LE, Schneider KA, Magness SM, Higano NS, Ollberding NJ, Hoyos Cordon X, Hirsch RM, Hysinger E, Woods JC, Critser PJ.Am J Respir Crit Care Med. 2024 Aug 1;210(3):318-328. doi: 10.1164/rccm.202310-1733OC.PMID: 38568735As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!
For today's episode, we go back to the origins of Autism. It seems necessary because of the recent shifts in what is Autism and the confusion in the rates of Autism. Autism was here in the 1930's, and it magically showed up in different areas of the world. (Part 2 on Asperger's "little professors" next). The two-part series intends to remember the phenotypes that appeared and became known as Autism.It is my opinion, the recent shifts in defining Autism could be rooted in questionable intentions. Regardless, one goal of the podcast is understanding and explaining Autism. By the end of the episode, and by the end of the two-part series, I hope you gain understanding of the Autistic Phenotype.Leo Kanner: Autistic Disturbances of Affective Contact http://www.autismtruths.org/pdf/Autistic%20Disturbances%20of%20Affective%20Contact%20-%20Leo%20Kanner.pdf0:00 Intro0:45 Erwin Schrödinger Quote; Quantum Physics; Missing link in Medicine2:56 Kanner's Autistic Disturbances of Affective Contact; Demographics3:52 Ages; Boys versus Girls; Phenotypes; Family History6:26 Important consideration of Family History- electricity and nnEMF; general observation and important phenotypes9:30 Anticipatory Motor Adjustment; Reflexes; Sensory and Adaptive Responses13:32 Monotonous Repetitions; Sameness15:26 Spelling and Language18:20 Commands and Intrusions18:57 Autism, not Autism and ADHD; Intense Fixations & Neuroplasticity; Default Mode Network; Sameness24:00 Oblivious to Others; Inattentive- It's not ADHD, it's Autism27:39 Changes & More on Sameness & Repetitions30:10 Rote Memory; Gastrointestinal: Timelines and MilestonesX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumemail: info.fromthespectrum@gmail.com
The ability of human pluripotent and somatic stem cells to differentiate into multiple cell types of the human body makes them uniquely useful to model human development and disease. As a result, these cells are shared, edited, and differentiated by laboratories across the world for basic research, clinical translation, and commercial applications. Large and genotypically diverse collections of pluripotent stem cells are being generated to support large cohort-scale research into conditions such as Parkinson's disease and amyotrophic lateral sclerosis, among many others. However, information about these cells, their derivatives, and the resulting data can be difficult to track due to a myriad of factors including poor naming practices, siloed datasets, and incomplete information on experimental practices in the published literature. As a result, the ability to maximize the utility of these cells and data from them is limited, and the rigor and reproducibility of the research and its application may be seriously compromised. Our guests today, who were part of the ISSCR Task Force that developed the Standards for the Use of Human Stem Cells in Research, will discuss in detail a framework to manage these issues using stem cell registries. GuestAndreas Kurtz, PhD, Fraunhofer Institute for Biomedical Engineering and the Berlin Institute of Health Center for Regenerative Therapies Christine Wells, PhD, University of Melbourne Centre for Stem Cell Systems HostMartin Pera, Editor-in-Chief, Stem Cell Reports and The Jackson LaboratoryX: @martinperaJAXSupporting ResourcesGuidelines for managing and using the digital phenotypes of pluripotent stem cell lines, Stem Cell ReportsAbout Stem Cell ReportsStem Cell Reports is the open access, peer-reviewed journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.X: @StemCellReportsAbout ISSCRWith nearly 5,000 members from more than 80 countries, the International Society for Stem Cell Research (@ISSCR) is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.ISSCR StaffKeith Alm, Chief Executive OfficerYvonne Fisher, Managing Editor, Stem Cell ReportsKym Kilbourne, Director of Media and Strategic CommunicationsJack Mosher, Scientific AdvisorVoice WorkBen Snitkoff
Send us a textBen and Daphna speak with Dr. Aaron Hamvas from Lurie Children's Hospital about his research on bronchopulmonary dysplasia (BPD) and its potential genetic factors. Dr. Hamvas discusses the complexities of BPD, including the role genetics might play in predisposing infants to the condition. He introduces the “Leopard Project,” a new NIH-funded study using AI and novel genomics techniques to explore long-term respiratory outcomes in preterm infants. Join the conversation for insights into how genetics and advanced data analysis could redefine our understanding of BPD and its lifelong impacts.As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!
Welcome to another live Q&A session from NeuroNoodle! In this episode, Pete Jansons hosts an expert panel, including Jay Gunkelman, Dr. Mari Swingle, Joy Lunt, Dr. Andrew Hill, Santiago Brand, Anthony Ramos, and John Mekrut. They dive deep into neurofeedback's impact on autism, ADHD, mental health, and brain training. Hear insightful discussions, real-time audience questions, and practical applications for neurofeedback therapy.
The Conversation is BACK, and in this episode, we welcome @Joint_the_huntsman back to the program. He's here to give us a full rundown of his latest breeding work - a DOUBLE drop coming this Friday. Did I mention that there's an official Cultivation Conversation grow along to go with this drop? WELL THERE IS! Get in on the game and grab a pack of beans or six at jcuniversal.link this Friday, 10/18.
The Conversation is BACK, and in this episode, we welcome @Joint_the_huntsman back to the program. He's here to give us a full rundown of his latest breeding work - a DOUBLE drop coming this Friday. Did I mention that there's an official Cultivation Conversation grow along to go with this drop? WELL THERE IS! Get in on the game and grab a pack of beans or six at https://jcuniversal.link/this Friday, 10/18. So sit back, relax, grab something to smoke on and get ready for a Cultivation Conversation. Please follow the show at @cultivation.conversation and follow your hosts at @girlgogrow, @therealgreenmonsta & @captainautoflower. Don't forget to like, comment, share & subscribe because all of that helps us A LOT! Thanks everyone and enjoy the show. DISCOUNT CODES AUTOPOTS - Use code "CC10" on autopot-usa.com MICROBELIFEHYDRO - Use code "CCMLH15" on https://microbelifehydro.com AC INFINITY - Use code "cultivation" on acinfinity.com INSECT FRASS - Use code "CC10" frassvalley.com EVERYTHING - Use code "CC10" on mass-hydro.com __________________________________________________ If you would like to support us on Patreon https://www.patreon.com/Cultivationconversation Join us on Discord https://discord.com/invite/xcCSBQxyYB Follow us on Twitch https://www.twitch.tv/cultivationconversation Our Website https://cultivationconversation.com/ Products We Use https://cultivationconversation.com/what-we-use/
In this episode, we discuss Autism and the Default Mode Network. According to Lisa Feldman-Barrett, the Default Mode Network has many names because it has been discovered, named, rediscovered, and renamed many times. I do not disagree with the Science regarding Autism and the Default Mode Network. However, I disagree with the Interpretation of the Data. This IS our Default; our preferred state; the core of the Autistic Phenotype.After listening to this episode and understanding B.3, you can understand MOST of Autism. The only reason you cannot understand ALL of Autism from these two episodes is the amount of Phenotypes branching off of B.3 and our Default Mode. Autism IS preference for ALONENESS and SAMENESS. This minimizes sensations and distractions that interfere with our internal world. This state is NOT abnormal, how society interferes with it makes it abnormal.If you want more Autistics to ACHIEVE, then understand your interaction, interference, and interpretation of what YOU think Autism is provides the delta of how much we are prevented in life. This, of course, becomes slightly different the more profound the Autistic Phenotype is with that specific person.In this episode, we will explore the different brain regions and the goals of these regions as it relates to our phenotypes. We will get into some "Thinking in Picture" and thinking styles. This will be a good time because of a future guest on From the Spectrum Podcast discussing Autism and Creativity. This is exciting for me.Lisa Feldman-Barrett Core System (DMN) https://lisafeldmanbarrett.com/2017/02/05/core-systems/0:41 Research at UT-Austin and the Importance of the INFRARED LIGHT study with Autism5:48 Autism and the Default Mode Network (DMN); Buzzword in Science7:19 Humans and our Prediction Machine and Sensory Processing; Innate or Learned; Oxytocin in the Autistic Phenotype;9:36 History of DMN (from Lisa Feldman-Barrett) and the many names; Core Systems11:58 medial Prefrontal Cortex (covered in many episodes); roles, E/I, connectivity, Internal Calculators14:45 Posterior Cingulate Cortex (PCC); Self-Referential Thinking, Memory, Attention, Task-Switching and the harms of calling it ADHD18:03 Angular Gyrus; Language, Sensory Processing "Bee Movie" example, Mental Images, Narratives, Empathy21:12 Supplementing Relationships23:36 Sensation-Perception24:30 Precuneus; Self-Awareness, Episodic Memory, Prediction and Strategic Planning25:52 Social Cognition; Social Cues and Skills27:50 Autism and Anxiety- Avoidance, Breathing (Physiology), and Valence (how we feel)28:48 Internal Calculators; Metabolic Bank Account and Demands29:26 the DMN is a Misnomer and the Default (tendency, phenotype) of the Autistic33:04 Reviews/Ratings, Contact InfoX: https://twitter.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumemail: info.fromthespectrum@gmail.com
Welcome to Season 2 of the Orthobullets Podcast. Today's show is Podiums, where we feature expert speakers from live medical events. This episode will feature Dr. Jean Jacques Abitbol, and is titled Understanding the Phenotypes of Low Back Pain. Follow Orthobullets on Social Media: Facebook Instagram Twitter LinkedIn YouTube
Charles Mayfield is the founder of Farrow Skincare, an animal-based skincare product that does not contain fillers, additives, and other harmful chemicals. Charles became fascinated by the benefits of lard on the skin when he made the connection between the biology of humans and pigs. The origins of Farrow all started after a long day out in the July Tennessee sun. Charles decided to use some lard from his farm to protect his skin from peeling out of necessity and it wasn't until the next day that he realized his skin never peeled and his burn had vanished. At that point, Charles realized he was on to something. Now, Charles is on a mission to bring lard-based skincare to the masses and convince people to throw away their toxic skin creams.Key topics discussed:- The benefits of cooking and consuming nutrient-dense, whole foods- The negative effects of modern lifestyle choices on physical health and how they can be reversed- The significance of using natural skincare products over conventional ones- The importance of understanding and improving metabolic health- The role of mental belief and positive mindset in the healing processTimestamps:(01:00) - The Bastardization of Pork in Media(02:00) - Historical Use of Lard and Tallow(05:00) - Modern Pig Breeding and Phenotypes(10:00) - Transition to Seed Oils and Fast Food Industry(12:00) - Skincare with Animal Fats(15:00) - Discussion on Sunscreens and Natural Alternatives(20:00) - Societal Health Decline and Reversal Opportunities*** SPONSOR ***CrowdHealth - They're providing an alternative to health care coverage in the form of a community-based approach.We've both used this service for the last two years. Check out their new Carnivore Crowd and if you sign up be sure to use code MEATMAFIA for a discount on your first 3 months!*** LINKS***Check out our Newsletter - Food for Thought - to dramatically improve your health this year!Join The Meat Mafia community Telegram group for daily conversations to keep up with what's happening between episodes of the show.Connect with Farrow Skincare:WebsiteTwitterInstagramConnect with Meat Mafia:Instagram - Meat MafiaTwitter - Meat MafiaYouTube - Meat MafiaConnect with Noble Protein:Website - Noble ProteinTwitter - Noble ProteinInstagram - Noble ProteinAFFILIATESLMNT - Electrolyte salts to supplement minerals on low-carb dietThe Carnivore Bar - Use Code 'MEATMAFIA' for 10% OFF - Delicious & convenient Pemmican BarPerennial Pastures - Use CODE 'MEATMAFIA' 10% OFF - Regeneratively raised, grass-fed & grass-finished beef from California & MontanaFarrow Skincare - Use CODE 'MEATMAFIA' at checkout for 20% OFFHeart & Soil - CODE ‘MEATMAFIA' for 10% OFF - enhanced nutrition to replace daily vitamins!Carnivore Snax - Use CODE 'MEATMAFIA' Crispy, airy meat chips that melt in your mouth. Regeneratively raised in the USA.Pluck Seasoning - 15% OFF - Nutrient-dense seasoning with INSANE flavor! Use CODE: MEATMAFIAWe Feed Raw 25% OFF your first order - ancestrally consistent food for your dog! Use CODE 'MEATMAFIA'Fond Bone Broth - 15% OFF - REAL bone broth with HIGH-QUALITY ingredients! It's a daily product for us! Use CODE: MAFIA This episode of the podcast is brought to you by the CarnivoreCrowd over at CrowdHealth. When we first quit our jobs to focus on the podcast and Noble Origins full-time, we immediately signed up for CrowdHealth. They just launched their CarnivoreCrowd, which is designed to bring together metabolically healthy individuals into a cost-sharing community for medical bills. I don't know about you guys, but it's great knowing that the other members of the community care about their health as much as I do. If you're interested in joining the CarnivoreCrowd, use the code MEATMAFIA for $99 for the first three months. Also, check out the founder of CrowdHealth on episode 240 of The Meat Mafia Podcast.
Send us a Text Message.In this episode of Causes or Cures, Dr. Eeks chats with Dr. Andres Acosta MD PHD about the identification of 4 phenotypes for obesity and how they can revolutionize the future of obesity treatment. In great detail, he describes the 4 obesity phenotypes (Hungry Brain, Emotional Hunger, Hungry Gut, and Slow Burn) and explains what treatment, diet, and exercise plan works for each. He also describes his company, Phenomix Sciences, a precision-medicine company that predicts how well someone will respond to various obesity interventions. Dr. Acosta is a Consultant of Gastroenterology and Hepatology at the Mayo Clinic, as well as an Associate Professor of Medicine. His research focus is on gastrointestinal physiology and the complexity of food intake regulation as it relates to obesity. You can learn more about his work here. You can contact Dr. Eeks at bloomingwellness.com.Follow Eeks on Instagram here.Or Facebook here.Or X.On Youtube.Or TikTok.SUBSCRIBE to her monthly newsletter here.Support the Show.
Dr. Nadia Khalil interviews Dr. Collin Grant on his experience in private practice. He shares his take on the highlights, challenges, and keys for success.
The Conversation is BACK, and in this episode, we discuss Schedule III, home gardening, summertime growing, a couple new products, and 3 leaf phenos. So sit back, relax, grab something to smoke on and get ready for a Cultivation Conversation. Please follow the show at @cultivation.conversation and follow your hosts at @girlgogrow, @therealgreenmonsta & @captainautoflower. Don't forget to like, comment, share & subscribe because all of that helps us A LOT! Thanks everyone and enjoy the show. DISCOUNT CODES AUTOPOTS - Use code "CC10" on autopot-usa.com MICROBELIFEHYDRO - Use code "CCMLH15" on https://microbelifehydro.com AC INFINITY - Use code "cultivation" on acinfinity.com INSECT FRASS - Use code "CC10" frassvalley.com EVERYTHING - Use code "CC10" on mass-hydro.com If you would like to support us on patreon Join us on discord Follow us on twitch Our website Products we use
Dr. Nadia Khalil interviews Dr. Ileana Howard and Dr. Kelly Gwathmey on their careers in neuromuscular medicine. They define a neuromuscular practice and highlight how meaningful, challenging, and exciting this field of medicine is.
Dr. Mrinalini Dey discusses abstract OP0202 presented at Eular 2024 in Vienna, Austria.
Dr. Nadia Khalil interviews Dr. Nicholas Johnson on a career in research. He describes what research in practice looks like, his inspiration, and pearls for success.
Dr. Nadia Khalil interviews Dr. Milind Kothari and Dr. Sandra Hearn on academic practice. They define what life as a clinician educator looks like and share pearls from their own journeys for success.
Are you effectively screening for all the phenotypes of concussion in your assessments? Many clinicians may not be fully screening for all seven phenotypes of concussion, potentially missing crucial factors in their clients' recovery process. Not screening adequately for all phenotypes could lead to prolonged recovery times for clients. By breaking down your assessments into the seven phenotypes and ensuring each is thoroughly addressed, you can provide more comprehensive care and support quicker recovery. In this episode, you'll learn:
Dr. Celina Nahyun Jo, one of the trainee editorial board members in Radiology: Imaging Cancer and a radiology resident at University of Texas Medical Branch in Galveston hosts our podcast series that summarizes interesting articles into a bite size. This podcast provides background knowledge for everyone to understand and enjoy oncologic imaging research on the go. This is bite size research for Radiology: Imaging Cancer, November 2023 issue." Current Status of Cancer Genomics and Imaging Phenotypes: What Radiologists Need to Know. Serrão et al. Radiology: Imaging Cancer 2023; 5(6):e220153.
“Focusing the GWAS Lens on days to flower using latent variable phenotypes derived from global multienvironment trials” with Sandesh Neupane and Derek Wright. Lentil, a pivotal pulse crop, is recognized as an important part of food and nutrition security in the world. It has rich sources of important nutrients, is easy to cook, and thrives well on the farm. Due to its rich dietary benefits, lentil has been introduced to North America, especially in Canada. Originating as a warmer climate crop, domesticated in the Middle East and North Africa, and widely adopted in Southeast Asia, lentil can face adaptation issues in the cooler Canadian climate. This struggle directly impacts flowering, pod-bearing, and overall yield. What precisely are the adaptation constraints hindering lentil introduction in North America? How do varying photoperiods and temperatures exert influence on lentil production? Delving deeper, what genes govern the crop's sensitivity to photoperiods and temperatures? In this episode, Sandesh Neupane and Derek Wright share insights into their research on lentil adaptation and how they dissect the genetic mechanisms orchestrating the photoperiod and temperature sensitivity in lentils with multi-location trials and advanced image-based phenotyping. This groundbreaking work promises to contribute significantly to the breeding of well-suited lentil varieties tailored to thrive in North American conditions. Tune in to learn about: · Lentil and its nutritional value · Lentil's history · The challenges of lentil adaptation in Canada · How the environment affects lentil growth If you would like more information about this topic, this episode's paper is available here: https://doi.org/10.1002/tpg2.20269 This paper is always freely available. Contact us at podcast@sciencesocieties.org or on Twitter @FieldLabEarth if you have comments, questions, or suggestions for show topics, and if you want more content like this don't forget to subscribe. If you'd like to see old episodes or sign up for our newsletter, you can do so here: https://fieldlabearth.libsyn.com/. If you would like to reach out to Derek Wright, you can find him here: derek.wright@usask.ca If you would like to reach out to Sandesh Neupane, you can find him here: sandesh.neupane@usask.ca If you would like to reach out to Om Prakash Ghimire from our Student Spotlight, you can find him here:oghimir@g.clemson.edu Twitter: https://twitter.com/baizalla Resources CEU Quiz: https://web.sciencesocieties.org/Learning-Center/Courses/Course-Detail?productid=%7b66CDC952-F899-EE11-BE37-000D3A32379C%7d Transcripts: https://www.rev.com/transcript-editor/shared/DTO7pupG1PWFmpaCbjNkVKnhQuE9eybRhp_s83uNy5AoLyIlNwjjoi5_3tjqm5lbMxn3ESqOuz1EuC4_GuWmV5Ri604?loadFrom=SharedLink Plant Sciences, Crop Development Centre – University of Saskatchewan: https://agbio.usask.ca/faculty-and-staff/people-pages/kirstin-bett.php#top/ Know Pulse - https://knowpulse.usask.ca/ Thank you to Om Prakash Ghimire for help on the creation of show notes and other assets. Field, Lab, Earth is Copyrighted by the American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America.
BUFFALO, NY- December 12, 2023 – A new #researchpaper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 22, entitled, “Tat-heat shock protein 10 ameliorates age-related phenotypes by facilitating neuronal plasticity and reducing age-related genes in the hippocampus.” In this new study, researchers Hyo Young Jung, Hyun Jung Kwon, Kyu Ri Hahn, Woosuk Kim, Dae Young Yoo, Yeo Sung Yoon, Dae Won Kim, and In Koo Hwang from Seoul National University, Chungnam National University, Gangneung-Wonju National University, Hallym University, and Konkuk University investigated the effects of heat shock protein 10 (HSP10) protein on memory function, hippocampal neurogenesis, and other related genes/proteins in adult and aged mice. “In the present study, we investigated the effects of HSP10 on hippocampal function in both adult and aged mice.” To translocate the HSP10 protein into the hippocampus, the Tat-HSP10 fusion protein was synthesized, and Tat-HSP10, not HSP10, was successfully delivered into the hippocampus based on immunohistochemistry and western blotting. Tat-HSP10 (0.5 or 2.0 mg/kg) or HSP10 (control protein, 2.0 mg/kg) was administered daily to 3- and 21-month-old mice for 3 months, and observed the senescence maker P16 was significantly increased in aged mice and the treatment with Tat-HSP10 significantly decreased P16 expression in the hippocampus of aged mice. In novel object recognition and Morris water maze tests, aged mice demonstrated decreases in exploratory preferences, exploration time, distance moved, number of object contacts, and escape latency compared to adult mice. Treatment with Tat-HSP10 significantly improved exploratory preferences, the number of object contacts, and the time spent swimming in the target quadrant in aged mice but not adults. Administration of Tat-HSP10 increased the number of proliferating cells and differentiated neuroblasts in the dentate gyrus of adult and aged mice compared to controls, as determined by immunohistochemical staining for Ki67 and doublecortin, respectively. Additionally, Tat-HSP10 treatment significantly mitigated the reduction in sirtuin 1 mRNA level, N-methyl-D-aspartate receptor 1, and postsynaptic density 95 protein levels in the hippocampus of aged mice. In contrast, Tat-HSP10 treatment significantly increased sirtuin 3 protein levels in both adult and aged mouse hippocampus. These suggest that Tat-HSP10 can potentially reduce hippocampus-related aging phenotypes. “Our results suggest that Tat-HSP10 treatment facilitates mitochondrial function, and Tat-HSP10 supplementation ameliorates the aging phenotypes in the mouse hippocampus.” DOI - https://doi.org/10.18632/aging.205182 Corresponding authors - Dae Won Kim - kimdw@gwnu.ac.kr, and In Koo Hwang - vetmed2@snu.ac.kr Keywords - aging, heat shock protein 10, hippocampus, memory, neurogenesis, synaptic plasticity About Aging-US Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at https://www.Aging-US.com and connect with us: SoundCloud - https://soundcloud.com/Aging-Us Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM
Generation Mixed is going global! Our first guest is from Canada!Hollay Ghadery joins us in a passionate discussion about growing up mixed race and mental health challenges she faced due to her identity. Her book, Fuse, which is a 2023 Canada BookClub award nominee, addresses these discussions.What mental health issues are being overlooked in our community?hollay.ghadery@gmail.comhttps://www.hollayghadery.ca/ IG @hollayghaderyX @Hollay2https://www.facebook.com/hollayghaderywriter/ What it means to be multiracial in America, one story at a time, from the studio to the streets.DOWNLOAD and SUBSCRIBE to Generation Mixed, on Apple, Spotify, IHeart, or Spreaker!FOLLOW us on:Instagram| @generationmixedpodcastWanna be on the show? Text or call 510-852-9550!Subscribe to our newsletter at www.Justjmarc.comPlease email us here with any suggestions, comments, and questions for future episodes.generationmixedpodcast@gmail.com
Ever wondered why concussion treatments often fall short? Are you familiar with the diverse phenotypes underlying concussion symptoms? Using a one-size-fits-all approach for concussion symptoms can lead to ineffective treatments and frustration for both patients and clinicians. Understanding the seven distinct concussion phenotypes is crucial. By recognizing these categories, clinicians can tailor treatments, ensuring precise and effective care for every patient. In this episode, you'll learn:
What are the ways that patients fail breathing trials, and what can they tell us about how to optimize them for next time?
Have you ever wondered why some concussion symptoms persist long after the injury, or why it's challenging to find the right treatment? Many people struggle with lingering concussion symptoms and often face uncertainty about the best way to address them. In this episode, we're diving deep into the seven different phenotypes of concussion to help you understand why your symptoms might be persisting and how to find effective solutions. In this episode, you'll learn:
#addiction #neurofeedback #neurofeedbacktherapy #phenotypes #mentalhealth #shorts #mentalhealthshorts Main Clip: https://youtu.be/QeJ7j9BfE3M Jay Gunkelman is the man who has read over 500,000 brain scans and in this short he talks about the phenotypes present on brains with addiction --- Send in a voice message: https://podcasters.spotify.com/pod/show/neuronoodle/message Support this podcast: https://podcasters.spotify.com/pod/show/neuronoodle/support
Today, Dr. Lisa explains how both our genes and our environment impact our weight, and what we can do to lose weight, whatever our genetics. She also explains how flamingos lose weight (...or is it how a flamingo's color is influenced by their genotype and phenotype...? Something like that!) If you're serious about understanding why some people find it easier to lose weight, and others struggle more, this episode will explain a piece of that puzzle.If you'd like more support during your SMART weight loss journey, check out our group coaching program at www.smartweightlosscoaching.comThis episode was produced by The Podcast Teacher.
ARDS Part II Special Guest: Steven Lemieux, PharmD, BCPS, BCCCP 03:45 – ESICM guidelines and ARDS definition 11:50 – Phenotypes and respiratory support 23:50 – Corticosteroids 34:40 – NMBA, pulmonary vasodilators, and VV ECMO 44:00 - Fun facts and take-home points Reference List: https://pharmacytodose.files.wordpress.com/2023/08/ards-part-ii-references.pdf PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices
Hyperbaric oxygen therapy (HBOT) is a medical treatment in which patients breathe pure oxygen at higher than normal atmospheric pressure. This increases the amount of oxygen dissolved in body tissues, enabling tissue rejuvenation and accelerated recovery. Historically, HBOT has been used for chronic wounds like diabetic foot ulcers, radiation injuries, and non-healing surgical wounds. However, the research on HBOT is evolving and has recently suggested its use can have regenerative effects on the brain. At the forefront of this research is the Sagol Center in Israel, where scientists have shown that HBOT can also induce brain tissue regeneration and neuroplasticity, even years after brain injuries. These findings are expanding HBOT's potential therapeutic uses for conditions like cognitive decline, traumatic brain injuries, stroke recovery, chronic pain, and other medical conditions. This episode of Longevity by Design features an exclusive interview with the founder and director of the Sagol Center, Dr. Shai Efrati. Dr. Efrati explains the science behind HBOT and how this treatment improves cognition. He details how oxygen fluctuations trigger the body's regenerative processes within the brain. He also underscores the importance of precision and exactness in using medical-grade equipment for this treatment, cautioning against the use of at-home hyperbaric oxygen therapies.TimestampsDr. Shai's background (00:00-15:28)How exercise promotes angiogenesis (15:30-18:40)Commercialization of Hyperbaric oxygen therapy (HBOT) (18:40–24:40) Health benefits of HBOT (24:40–31:31)Optimal HBOT protocol for improved cognition (31:32–37:22)Is HBOT beneficial for younger populations? (37:22–45:00)Can HBOT benefit individuals with impaired brain function? (45:01–50:40)Alzheimer's disease: Phenotypes and treatment (50:41–58:10)Top tip for brain health (58:10–end)Stay up to date at https://info.insidetracker.com/longevitybydesign
Dr. David Perez discusses the diagnosis of FND and new phenotypes. This episode was sponsored by the ExTINGUISH Trial for NMDAR Encephalitis: Call 844-4BRAIN5 to refer patients.
In this week's episode of grow guides we talk about landraces, hybrids and phenotypes. We also have the pleasure of having our friend Angus from The Real Seed Company on the panel. During the episode we have a great discussion about what landraces are, what is a hybrid cannabis strain and what are phenotypes. This episode is packed full of awesome information that any cannabis grower will find useful. So roll yourself a fat one, get a little high and get ready to learn lots about our favourite plant. Of course we also have a few great questions from our listeners that we answer towards the end of the show. Including, how do hermies work! Its a real good show, I hope you enjoy this episode. If you need any help then please feel free to contact us on our website, Discord server, or any of your favourite social networks. Visit our website for links. Website: https://highonhomegrown.com Discord: https://discord.gg/sqYGkF4xyQ Youtube: https://www.youtube.com/highonhomegrown Thank you for downloading and listening to our cannabis podcast! I hope you have enjoyed this episode.
EP. 69: ADAPTIVE METABOLISMS & METABOLIC PHENOTYPES: SPENDTHRIFT VERSUS THRIFTY PHENOTYPES TOPICS: INTRODUCTION TO THE TOPIC OF ADAPTIVE METABOLISMS WHAT IS A METABOLIC PHENOTYPE? WHAT IS THE DIFFERENCE BETWEEN A SPENDTHRIFT AND THRIFTY PHENOTYPE? DOES HAVING A THRIFTY METABOLISM LEAD TO LESS SUCCESS IN A FAT LOSS PHASE AND A LOWER LIKELIHOOD OF LONG TERM WEIGHT LOSS MAINTENANCE? DO THOSE WITH A THRIFTY METABOLIC PHENOTYPE HAVE A LOWER TDEE WHEN EATING AT MAINTENANCE DUE TO HAVING A MORE ADAPTIVE METABOLISM? OUR OWN EXPERIENCE WITH DIFFERENT PHENOTYPES AND ADAPTIVE METABOLISMS
In this first episode of our three-part series, Prof. Jon Stone talks with Drs. Selma Aybek, David Perez, and Sarah Lidstone about FND diagnosis and exploring new phenotypes. Associated Links: FND Society at fndsociety.org FND guide for patients at neurosymptoms.org FND Hope at fndhope.org Visit NPUb.org/Podcast for associated article links. This episode was sponsored by the ExTINGUISH Trial for NMDAR Encephalitis: Call 844-4BRAIN5 to refer patients.
Season 5 of the Pot Moms Podcast has a new twist on parenting and cannabis. In this week's episode, Kait and Natalie launch the first of a multi-part series around Cannabis Education! Continuing through M, N, O and P, they cover two different types of terpenes; myrcene, neridiol, OG strains and PHENOTYPES! Education is a huge way to break down stigma and find common ground and topics to speak with cannabis consumers and non-consumers alike. Tune in each week as they provide an open and honest perspective on cannabis-use as it relates to parenting, mental health, and life in general. Connect with the Pot Moms Podcast on Instagram @PotMomsPodcast, or reach out PotMomsPodcast@gmail.com with questions.
Dr. Curtis Nickel, a professor of urology and urologist at Queens University in Kingston, Ontario joins Callie to discuss his work studying and educating people about interstitial cystitis. Dr. Nickel discusses his career trajectory from microbiology to urology and his experiences along the way. As one of the pioneers in research on interstitial cystitis and chronic prostatitis, Dr. Nickel shares his findings and the evidence behind an individualized approach to treatments for IC and chronic prostatitis. Dr. Nickel, as a professor, also sees how little discussion of IC happens in medical school and training. He talks about his approach to educating urologists to better treat IC. Being a physician in Canada is much different in practice than in the United States, especially treating IC and Dr. Nickel discusses these differences, from treatment approaches and reimbursement for physicians to guidelines for diagnosis and treatment. Dr. Nickel also breaks down the “phenotype system” approach to treatment he developed. The episode wraps up with Dr. Nickel discussing other aspects of treating IC he utilizes including mental exercises, patient education, and elimination diets. Tune in to hear from a physician and IC expert and his advice for patients! Connect with Dr. Curtis Nickel Instagram: TikTok: Website: https://urology.queensu.ca/faculty/j-curtis-nickel Work with me: Road To Remission For the IC Warrior ready to take ACTION and identify their triggers Intro To IC Mini Course For the IC Warrior looking to learn more about the condition The IC Collective For the IC Warrior craving a community Connect with me! Instagram Facebook Pinterest Website Email: support@callieknutrition.com
Reference J BiolChem. 2023 Mar; 299(3): 103019. --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message
How can we match our patients with the best treatment options that will work for them? This is the big question when treating a vastly heterogenous disease like obesity. Rather than using trial and error, what if we could phenotype our patients and choose a treatment that is most likely to be successful for that specific patient? It may sound too good to be true, but this is the type of science and precision medicine that Dr. Andres Acosta and his team at Mayo are making a reality. Dr. Acosta's goal is to treat and ultimately cure obesity, which he considers this century's greatest health epidemic. Dr. Acosta's work on individualized obesity therapy aims to identify the right therapy for the right patient, minimizing side effects.Andres Acosta, MD, PhD is a Physician scientist, Obesity and Diabetes Expert, and serial entrepreneur. He is faculty at the Mayo Clinic in Rochester Minnesota and focuses his research on gastrointestinal physiology to understand the complexity of food intake regulation and obesity. Dr. Acosta's laboratory utilizes a combination of genetics, physiology, pharmacology, proteomics, metabolomics, and gastrointestinal and brain imaging to understand food intake regulation and to modulate them for the treatment of obesity. He and his colleagues at Mayo are also using cutting-edge techniques to understand the pharmacotherapy and pharmacogenomics of obesity and how this information can be used to optimize the care of patients with obesity.To read the full journal articles of the studies discussed: Selection of antiobesity medications based on phenotypes enhances weight loss: A pragmatic trial in an obesity clinicPhenotype tailored lifestyle intervention on weight loss and cardiometabolic risk factors in adults with obesity: a single-centre, non-randomised, proof-of-concept studySupport the showThe Gaining Health Podcast will release a new episode monthly, every second Wednesday of the month. Episodes including interviews with obesity experts as well as scientific updates and new guidelines for the management of obesity.If you're a clinician or organization looking to start or optimize an obesity management program, and you want additional support and resources, check out the Gaining Health website! We offer monthly and annual Memberships, which include live group coaching, a community forum to ask questions and post resources, pre-recorded Master Classes, digital resources inlcuding patient education materials and office forms, and much more! We also sell our popular Gaining Health products, including a book on developing an obesity management program, editable forms and templates, and patient education materials in our Gaining Health Shop! If you are loving this podcast, please consider supporting us on Patreon
Dr. Jenny Thomas, PhD What is Avoidant Restrictive Food Intake Disorder? Restriction without body image What would cause someone to restrict food if it wasn't to change the body? Phenotypes described - Three types can occur in same individual Sensory sensitivity presentation – textures Trauma – vomiting, choking, pain in belly Lack of Interest – “I forget to eat”, don't get hungry and get full quickly (ARFID Plus) What works? - Exposure therapy, Cooking therapy, sometimes speech therapy, eating at regular times, the body will come to expect that. Division of responsibility doesn't match this diagnosis. Enough preferred foods first so enough calories, then slowly introduce variety. CBT-AR – patients will report hunger simply from the act of eating. Develop a cadence of appetite. What does CCK have to do with this? NIMH study –Adults with ARFID 2022-2027 Dr. Thomas' Seasonings: Organizations Academy for Eating Disorders (AED, organization for professionals) — https://www.aedweb.org/home Feeding Matters (organization for families) — https://www.feedingmatters.org Books about ARFID Cognitive-Behavioral Therapy for Avoidant/Restrictive Food Intake Disorder (treatment manual) Picky Eater's Recovery Book (CBT self-help book for adults) Assessments for ARFID PARDI (clinical interview for ARFID; click on “supporting information” at this link for a copy of the full interview) — https://onlinelibrary.wiley.com/doi/10.1002/eat.22958 PARDI-AR-Q (self-report screening questionnaire for ARFID) — https://jeatdisord.biomedcentral.com/articles/10.1186/s40337-022-00706-7 Opportunities for participation in ARFID research studies Neurobiological underpinnings of avoidant/restrictive food intake disorder in adults — https://rally.massgeneralbrigham.org/study/answer Bio: Dr. Jennifer Thomas is the Co-director of the Eating Disorders Clinical and Research Program at Massachusetts General Hospital, and an Associate Professor of Psychology in the Department of Psychiatry at Harvard Medical School. Dr. Thomas's research focuses on avoidant/restrictive food intake disorder and other atypical eating disorders, as described in her books Almost Anorexic: Is My (or My Loved One's) Relationship with Food a Problem?; Cognitive-Behavioral Therapy for Avoidant/Restrictive Food Intake Disorder: Children, Adolescents, and Adults; and The Picky Eater's Recovery Book: Overcoming Avoidant/Restrictive Food Intake Disorder. She is currently principal investigator on several studies investigating the neurobiology and treatment of avoidant/restrictive food intake disorder, funded by the U.S. National Institute of Mental Health and private foundations. She is the author or co-author of more than 160 scientific publications. She is the current President of the Academy for Eating Disorders and recently completed a 5-year term as Associate Editor for the International Journal of Eating Disorders. With your host Beth Harrell IG @beth.harrell.cedss Supervision Freebies
We have come a long way in our understanding of the “Stein and Leventhal Syndrome”. First described in 1935, our understanding of the pathogenesis and future health morbidities of PCOS has grown exponentially. We now know that AMH levels may help in the certain PCOS diagnoses. At the center of this clinical condition lies insulin resistance (IR). One of the manifestations of IR is Acanthosis nigricans (AN). (But AN can also be a marker of a much more deadly condition.) It is important to remember that not all PCOS patients are the same. In this episode, we will review the 4 phenotypes of PCOS and discuss a specific variant of the condition which is called the “lean PCOS variant”.
Commentary by Dr. Valentin Fuster
#sleep #adhd #neurofeedbackpodcast #neurofeedbackpodcast Dr. Licata is founder, and Director, of Vital Head and Spine. He Joins Jay Gunkelman the man who has read well over 500,000 Brain Scans and Pete Jansons on the NeuroNoodle Neurofeedback Podcast to discuss Sleep Issues and How Sleep and Attention Affect each other. Other Topics: Concussion Recovery, The 3 sleep Stages, Why We Sleep, Matthew Walker, Andrew Huberman, ADD, Epilepsy, Sleep Spindle, Phenotypes, Sleep and Attention Disorders, The Book "Why We Sleep" By Matthew Walker Hippocampus, Deep Sleep, Learning, Theta Waves, K Complex, EEG, Primary Lambda, Vigilance Awake, Kids are sleeping less than 1999 so much so that the Theta Beta Ratio Test is no longer a sure thing, working memory, Identifying ADD Biomarkers in Kids, Sleep Hygiene, Flushing the toilet of the brain while we sleep, Sleep wake cycle, Sleep Apnea, Barry Sterman, methylphenidate, Sleep Brain Patterns, Elite Athletes and Sleep, Suisun City Summit https://www.vitalheadandspine.com/ https://www.linkedin.com/in/dr-giancarlo-licata-dc-qeeg-d-757ba241/ Dr. Licata Bio: https://www.vitalheadandspine.com/about-us Giancarlo Licata, BA, BS, DC, qEEG-D (candidate), Dr. Licata is founder, and Director, of Vital Head and Spine. His focus is on Applied Neuroscience, Concussion recovery, and Interprofessional Collaboration. Having cared for thousands of patients with chronic pain, migraines, and concussions, Dr Licata deepened his expertise with Andrew Hill, PhD at Peak Brain Institute, and Tiff Thompson, Phd at Neurofield Neurotherapy. He now works closely with world renowned EEG expert Jay Gunkelman to better understand and improve concussion recovery, attention, sleep, and anxiety. His unique combination of evidence-based tools in EEG, qEEG, ERP, and applied neuroscience is used to create one of the leading applied neuroscience centers in the country. Dr Licata speaks nationally on topics including Brain Health, Sleep Science, Performance Science, Concussion Management, and has been featured on ABC, Huffington Post, and national podcast interviews. --- Send in a voice message: https://anchor.fm/neuronoodle/message Support this podcast: https://anchor.fm/neuronoodle/support
When it comes to losing weight and body recomposition, it's not as simple as just eating in a calorie deficit. There are many lifestyle, physiological and physical aspects that come into play, from a survival point of view. In today's episode, we discuss the different ways in which we can calculate a calorie deficit that is right for you and how to increase your awareness around the individual adaptations that can occur when you start to diet. Please leave us a review to let us know what you think of our podcast
Evaluation of patients with Cardiogenic Shock. Part one of who knows how many episodes I will create on this topic. Definition, Clinical Manifestations, Phenotypes and an Introduction to Management Strategies Show Notes: https://eddyjoemd.com/cardiogenic-shock-mcs/ TrueLearn Link: https://truelearn.referralrock.com/l/EDDYJOEMD25/ Discount code: EDDYJOEMD25 --- Support this podcast: https://anchor.fm/eddyjoemd/support
Andrew Scarborough is a proactive cancer patient and public health advocate, scrutinising the latest research in order to devise his own optimal metabolic approach in an attempt to manage his disease. He is also an inquisitive researcher, using critical analysis and independent thought to support his university studies. Prior to his diagnosis of a highly vascular Anaplastic Astrocytoma brain tumour, he studied for a masters in Nutritional Therapy and worked as a personal trainer. He is currently studying Human Biology and Medical Science at the University of Westminster, where he is heavily involved with brain tumour research. He mixes practical experience of metabolic therapies with a detailed understanding of its potential for cancer management and seizure control at the cellular level. Isabella D Cooper majored with honours in biochemistry with medical physiology, molecular genetics, advanced cell biology, advanced cancer biology, physiological networks (neurology, endocrinology and immunology), proteins and enzyme biochemistry, bioinformatics in influenza, and metabolic biochemistry. She has won multiple awards in multiple consecutive years, those include the Faculty of Science and Technology Awards, Individual Teaching Award and Group Teaching Award for Medical Physiology, Dean's List Awards and Biochemical Society Award. In addition, Isabella is an Associate Fellow of the Higher Education Academy, Affiliate of the Endocrine Society, Affiliate of the Physiological Society and Associate Member of the Royal Society of Biology. Isabella's PhD research is in hyperinsulinemia and ketogenic sciences. Her work involves human intervention trials and ex vivo work, with samples from research participants. Furthermore, Isabella has developed co-culture ex vivo and in vitro hybridisation cell stimulation experiments, to gain further insight into cellular mechanisms of action. Isabella is the lead author of the recently published paper in the BMJ Open Heart: Relationships between hyperinsulinemia, magnesium, vitamin D, thrombosis and COVID-19: rationale for clinical management. https://openheart.bmj.com/content/7/2/e001356 See https://beatbraincancer.co.uk/ for more information. Timestamps: 00:00 Nutritional ketosis, research 07:51 Hyperinsulinemia and cancer 12:51 Phenotypes 17:59 Long-term ketosis, intervention study 27:08 Oral glucose tolerance test 32:05 Is protein bad for us? 42:26 Metabolic damage from processed foods 52:13 Meat vs cancer See open positions at Revero: https://jobs.lever.co/Revero/ Join Carnivore Diet for a free 30 day trial: https://carnivore.diet/join/ Book a Carnivore Coach: https://carnivore.diet/book-a-coach/ Carnivore Shirts: https://merch.carnivore.diet Subscribe to our Newsletter: https://carnivore.diet/subscribe/ . #revero #shawnbaker #Carnivorediet #MeatHeals #HealthCreation #humanfood #AnimalBased #ZeroCarb #DietCoach #FatAdapted #Carnivore #sugarfree
The Grow From Your Heart Podcast - Hosted by Rasta Jeff of Irie Genetics
Join us on Discord! https://discord.gg/iriearmy Support the show on Patreon! https://www.patreon.com/GrowFromYourHeart Get your Irie Genetics Shirts Here! https://www.etsy.com/shop/IrieGiftsLLC Send questions, corrections, comments and concerns to GrowFromYourHeart@hotmail.com. Thank you for watching! Take a fat dab and give your mom a hug for me! The Grow From Your Heart Podcast was written and produced by Rasta Jeff. All content property of The ... Read More
The Grow From Your Heart Podcast - Hosted by Rasta Jeff of Irie Genetics
Join us on Discord! https://discord.gg/iriearmy Support the show on Patreon! https://www.patreon.com/GrowFromYourHeart Get your Irie Genetics Shirts Here! https://www.etsy.com/shop/IrieGiftsLLC Send questions, corrections, comments and concerns to GrowFromYourHeart@hotmail.com. Thank you for watching! Take a fat dab and give your mom a hug for me! The Grow From Your Heart Podcast was written and produced by Rasta Jeff. All content property of The Grow From Your Heart Podcast©
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