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Tony Zhang looks at banks as regionals rally on Powell's Jackson Hole commentary. “It really comes down to lower interest rates,” he argues, especially for regional banks exposed to real estate. He covers names he likes in the sector, including Truist (TFC), pointing to chart technical and valuation. Tony shares an example options trade on TFC with a bullish bent. He also gives his take on Nvidia (NVDA) after earnings.======== Schwab Network ========Empowering every investor and trader, every market day.Options involve risks and are not suitable for all investors. Before trading, read the Options Disclosure Document. http://bit.ly/2v9tH6DSubscribe to the Market Minute newsletter - https://schwabnetwork.com/subscribeDownload the iOS app - https://apps.apple.com/us/app/schwab-network/id1460719185Download the Amazon Fire Tv App - https://www.amazon.com/TD-Ameritrade-Network/dp/B07KRD76C7Watch on Sling - https://watch.sling.com/1/asset/191928615bd8d47686f94682aefaa007/watchWatch on Vizio - https://www.vizio.com/en/watchfreeplus-exploreWatch on DistroTV - https://www.distro.tv/live/schwab-network/Follow us on X – https://twitter.com/schwabnetworkFollow us on Facebook – https://www.facebook.com/schwabnetworkFollow us on LinkedIn - https://www.linkedin.com/company/schwab-network/About Schwab Network - https://schwabnetwork.com/about
UFC CEO Dana White announced a number of big fights, including Jack Della Maddalena vs. Islam Makhachev for the welterweight title as the main event for UFC 322 at Madison Square Garden, along with Valentina Shevchenko defending her flyweight title against Zhang Weili in the co-main event, as Zhang officially is vacating the strawweight title. Following the major news, MMA Fighting's Mike Heck and E. Casey Leydon react to those massive fights, along with Leon Edwards vs. Carlos Prates on the MSG card. Additionally, they discuss Virna Jandiroba vs. Mackenzie Dern for the vacant strawweight title at UFC 321 and other additions to the promotion's return to Abu Dhabi, White saying the White House card is a go for next July, and much more! Follow Mike Heck: @m_heckjr Follow E. Casey Leydon: @ekc Subscribe: http://goo.gl/dYpsgH Check out our full video catalog: http://goo.gl/u8VvLi Visit our playlists: http://goo.gl/eFhsvM Like MMAF on Facebook: http://goo.gl/uhdg7Z Follow on Twitter: http://goo.gl/nOATUI Read More: http://www.mmafighting.com Learn more about your ad choices. Visit podcastchoices.com/adchoices
UFC CEO Dana White announced a number of big fights, including Jack Della Maddalena vs. Islam Makhachev for the welterweight title as the main event for UFC 322 at Madison Square Garden, along with Valentina Shevchenko defending her flyweight title against Zhang Weili in the co-main event, as Zhang officially is vacating the strawweight title. Following the major news, MMA Fighting's Mike Heck and E. Casey Leydon react to those massive fights, along with Leon Edwards vs. Carlos Prates on the MSG card. Additionally, they discuss Virna Jandiroba vs. Mackenzie Dern for the vacant strawweight title at UFC 321 and other additions to the promotion's return to Abu Dhabi, White saying the White House card is a go for next July, and much more! Follow Mike Heck: @m_heckjr Follow E. Casey Leydon: @ekc Subscribe: http://goo.gl/dYpsgH Check out our full video catalog: http://goo.gl/u8VvLi Visit our playlists: http://goo.gl/eFhsvM Like MMAF on Facebook: http://goo.gl/uhdg7Z Follow on Twitter: http://goo.gl/nOATUI Read More: http://www.mmafighting.com Learn more about your ad choices. Visit podcastchoices.com/adchoices
UFC CEO Dana White announced a number of big fights, including Jack Della Maddalena vs. Islam Makhachev for the welterweight title as the main event for UFC 322 at Madison Square Garden, along with Valentina Shevchenko defending her flyweight title against Zhang Weili in the co-main event, as Zhang officially is vacating the strawweight title. Following the major news, MMA Fighting's Mike Heck and E. Casey Leydon react to those massive fights, along with Leon Edwards vs. Carlos Prates on the MSG card. Additionally, they discuss Virna Jandiroba vs. Mackenzie Dern for the vacant strawweight title at UFC 321 and other additions to the promotion's return to Abu Dhabi, White saying the White House card is a go for next July, and much more! Follow Mike Heck: @m_heckjr Follow E. Casey Leydon: @ekc Subscribe: http://goo.gl/dYpsgH Check out our full video catalog: http://goo.gl/u8VvLi Visit our playlists: http://goo.gl/eFhsvM Like MMAF on Facebook: http://goo.gl/uhdg7Z Follow on Twitter: http://goo.gl/nOATUI Read More: http://www.mmafighting.com Learn more about your ad choices. Visit podcastchoices.com/adchoices
A thoroughly dispiriting night of fights with two bright spots: Charles Johnson letting out his inner G, and Sergei Pavlovich beating a top heavyweight prospect by being only slightly good at MMA. Predatory instinct: how Max Holloway attacks - read my latest breakdown on Substack: https://open.substack.com/pub/facepunching/p/predatory-instinct-how-max-holloway?r=evbq&utm_campaign=post&utm_medium=web&showWelcomeOnShare=false Talking about how MVP is the only Bellator/PFL guy currently killing it in the UFC, plus Loopy Godinez, Lone'er Kavanagh, and more in our latest bonus episode: https://www.patreon.com/heavyhands Heavy Hands merch: https://www.redbubble.com/shop/ap/64577943?asc=u CONTENTS: 00:00 Intro 2:40 Walker vs Zhang 18:23 Sterling vs Ortega 38:29 Pavlovich vs Cortes-Acosta 47:44 Johnson vs Kavanagh
Live from the Battle Born Broadcast Center, ProFootballTalk NFL insider, Myles Simmons joins Cofield & Company to discuss the news of Travis Kelce getting engaged to Taylor Swift, review the Las Vegas Raiders' addition of wide receiver Amari Cooper, and give his thoughts on the Baltimore Ravens signing safety, Kyle Hamilton to a four-year, $100 million contract extension. Dan Mullen's comments following the UNLV Rebels' 38-31 season-opening victory over Idaho State. Sports writer & broadcaster, Ryan McKinnell joins Cofield & Company live from the Battle Born Broadcast Center to preview Notre Dame's season-opening match up against the Miami Hurricanes, review Brian Ortega's weight cut struggles in the co-main event of UFC Fight Night: Walker vs Zhang, and detail Logan Paul's attempts to overtake Jon Cena's role in the WWE.
Carlo and Sean recap last weeks UFC Fight Night 257: Walker vs. Zhang in China as well as events from the PFL and ONE Championship. They then look forward to this weekend's CJI 2 in Las Vegas and DAZN's Misfits 22 – Ring of Thrones.Watch our live stream on Millions.cohttps://millions.co/seanpierreInstagram: www.instagram.com/sean_pierre_Instagram: www.instagram.com/hapki1**MERCH!**Limited Edition MB Podcast Episode 100 TeeThe Mighty Beast Podcast "Shut Up White Belt" tee via Amazon PrimeThe Mighty Beast Podcast "Noob Aficionado" tee via Amazon PrimeThe Mighty Beast Podcast "Signature" tee via Amazon PrimeThe Mighty Beast Podcast "SHOGUN" zip up hoodie via Amazon Prime
Bichula welcomes Drew the Podcaster to discuss the concept of God in social media. Sources —>O'Connell, Robert J. William James on the Courage to Believe. Second edition., FordhamUniversity Press, 2019, https://doi.org/10.1515/9780823285211.Rauth, Joe. "Proverbs 3:5-6." YouTube, uploaded by Joe Rauth, 19 Jan. 2025,https://youtu.be/q2zomH-jAWo?si=rriBsCdeTkfa3XqlJunguo, Zhang. "A Critical Examination of Anselm's Ontological Argument." Frontiers ofPhilosophy in China, vol. 12, no. 1, 2017, pp. 137-50,https://doi.org/10.3868/s030-006-017-0010-8.
V oslabené sestavě jsme probrali PFL, Road to UFC a UFC Walker vs Zhang a mrkli jsme i na blížící se akce Misfits, Dirty Boxing a Craig Jones Invitational. PODPOŘ PODCASThttps://herohero.co/fairplaythinkerhttp://www.fptshop.cz/ https://merchmarket.cz/eshopy/mma-shorties/ FANTASY LIGAhttps://mmashortiesfantasy.cz/ JAN HOMOLKA https://www.instagram.com/homolak PAVEL BARTOŠhttps://www.instagram.com/mma_shorties RADIM KRAJLhttps://www.instagram.com/rkacko1/ JAN NOVÁKhttps://www.instagram.com/honza_novak_ PARTNEŘIhttps://www.egocombat.cz/http://www.legendapraha.cz/https://bit.ly/3FkF12A Link na Tipsort registraci s bonusem https://goldnutrition.cz/ Promocode: homolak10https://www.monsterenergy.com/cz/cs/homehttps://www.mmashorties.cz
In this episode of Bring the Pain, I reviewed UFC Shanghai, which featured Walker vs. Zhang in the main event. I talked about the Fight Club of Pain and how we nailed more big bets and parlays this week in which we slayed the sportsbooks while sleeping. After that, I talked about the break this week before coming back on Thursday for UFC Paris, which has Imavov vs. Borrahlo, as the main event. That also will be the opening game for the NFL, so expect a Showdown Slate lineup for Thursday night football every single week. That's how we do it at Dr. Roto. Have a great day, everyone, and may the fights be with you.
Nighttime dining, shopping and travel are thriving across China this summer, injecting fresh momentum to economic growth at a time when the country has prioritized consumption as its top priority this year.今年夏季，我国夜间餐饮、购物、旅游等消费业态蓬勃发展。在国家将消费列为今年工作重点的背景下，夜间经济为经济增长注入了新动能。The market size of China's nighttime economy has so far surpassed 50 trillion yuan ($7 trillion), said marketing consultancy Zhiyanzhan.More restaurants have extended business hours and launched delivery services to attract late-night diners and increase revenue.市场咨询机构智研瞻产业研究院数据显示，目前我国夜间经济市场规模已突破50 万亿元（约合 7 万亿美元）。为吸引夜宵客、提升营收，越来越多餐饮企业延长营业时间，并推出外卖服务。Huda Restaurant, a popular crayfish eatery in Beijing's bustling Guijie Street, is operating four outlets in the same area, cumulatively serving more than 6,500 customers daily on average. During peak hours on some nights, customers sometimes have to wait in line for three hours, according to the restaurant.位于北京繁华簋街的热门小龙虾餐厅“胡大饭店”，在该区域布局了 4 家门店，日均总客流量超 6500 人次。据餐厅介绍，部分夜晚的高峰时段，顾客有时需排队 3 小时才能就餐。"Tourists are often unable to wait that long to dine in. Some choose the takeaway option, or order deliveries to their hotels. Some 70 percent of our takeout orders come from nearby hotels, as many tourists tend to order deliveries at night after their daytime sightseeing in the city," said Zhang Shengtao, deputy general manager of Huda.“很多游客等不了那么久，有的会选择打包带走，有的则直接点外卖送到酒店。我们约 70% 的外卖订单来自周边酒店 —— 不少游客白天在市区观光后，晚上习惯点外卖。” 胡大饭店副总经理张胜涛说。"We take food delivery platforms as an important supplement to our operations, as the platforms allow customers to search for our restaurant from different channels. With no increase in the number of staff members and no change in restaurant areas, delivery services can help raise order volumes and lead to profit growth," Zhang said.他表示：“我们把外卖平台当作经营的重要补充，这些平台能让顾客通过多种渠道找到我们。在不增加员工、不扩大门店面积的情况下，外卖业务能帮助提升订单量，进而带动利润增长。”The restaurant chain said diners aged between 25 and 39 account for a large share of its total customers, while consumers opting for deliveries are mainly aged between 18 and 35.该餐饮连锁品牌透露，25 至 39 岁的顾客占堂食总客流的较大比例，而选择外卖的消费者以 18 至 35 岁人群为主。Hong Yong, an associate research fellow at the Chinese Academy of International Trade and Economic Cooperation, said the availability of nighttime dining meets the demand for late night snacking among urban white-collar employees and many young consumers, especially as more people stay up late, work overtime, or venture out for social entertainment, and late night dining gradually becomes a part of their daily routine.中国国际贸易促进委员会国际贸易经济合作研究院副研究员洪勇指出，夜间餐饮的普及，满足了城市白领及众多年轻消费者的夜宵需求。如今熬夜、加班、外出社交娱乐的人群增多，夜宵逐渐成为他们日常生活的一部分。"Nighttime economic activities such as dining, night tours and shopping provide richer consumption scenarios, and meet consumers' demand for leisure and entertainment, social interaction and emotional release," Hong said.“餐饮、夜游、购物等夜间经济活动，提供了更丰富的消费场景，满足了消费者休闲娱乐、社交互动、情感释放的需求。” 洪勇说。"The expansion of nighttime consumption scenarios will help promote the diversification of consumption formats, encourage higher frequencies of spending, effectively stimulate domestic demand and promote sustained economic growth momentum," he added.他补充道：“夜间消费场景的拓展，有助于推动消费业态多元化，提高消费频次，有效激发内需，为经济持续增长注入动力。”According to a report released by the Ministry of Commerce, 60 percent of China's urban consumption takes place after dusk. At large-scale malls, sales between 6 pm and 10 pm usually account for over half of the whole day's revenue.商务部发布的报告显示，我国60% 的城市消费发生在傍晚之后。在大型商场，18 时至 22 时的销售额通常占全天营收的一半以上。Shui Tea Shop, a tea drink brand based in Jinan, Shandong province, now operates some 1,400 stores nationwide, which are mainly located in Shandong, Jiangsu and Hebei provinces, as well as Tianjin and Beijing.总部位于山东济南的茶饮品牌“阿水大杯茶”，目前在全国拥有约 1400 家门店，主要分布在山东、江苏、河北三省及天津、北京两地。Since June, some of its stores began to extend their business hours. Now, over 300 stores operate until 11 pm, more than 100 stores operate until midnight, and a further 100 outlets are open beyond midnight. The extension of business hours will last until the end of September, the company said.该公司表示，自今年6 月起，部分门店开始延长营业时间：目前超 300 家门店营业至 23 时，100 余家营业至次日 0 时，另有 100 家门店营业至凌晨之后，这一延长营业时间的举措将持续至 9 月底。"After extending the business hours, there has been a clear trend of growth in store revenue, and some stores have experienced sales growth of over 100 percent compared with the period before the extension," said Wei Qun, director of delivery services at A-Shui Tea Shop.“延长营业时间后，门店营收增长趋势明显，部分门店销售额较延长前增长超 100%。” 阿水大杯茶外卖业务负责人魏群说。"Nighttime sales have been especially high in Jinan and Qingdao of Shandong, as well as Tianjin. Stores with higher revenues are mainly located in core business circles, and nighttime sales mainly come from orders for deliveries," Wei said.“山东的济南、青岛以及天津等地的夜间销售额表现尤为突出。高营收门店主要集中在核心商圈，夜间销售以外卖订单为主。” 魏群介绍。He added that in summer, many consumers are interested in having barbecues and crayfish at night, and restaurants providing such meals located in core business districts have largely extended their operating hours. Their popularity has also driven the sales growth of beverages, as certain drinks pair nicely with these kinds of food.他还提到，夏季夜晚，不少消费者喜欢吃烧烤、小龙虾，核心商圈内提供这类餐食的餐厅大多延长了营业时间。这些餐饮的火爆也带动了饮品销量—— 部分饮品与这类食物搭配口感更佳。In addition to the catering sector, many sightseeing spots have extended their opening hours this summer, and upgraded night tourism products to meet the diverse demand of travelers. Besides driving an increase in ticket revenue for scenic spots, it has promoted the growth of related businesses such as catering, accommodation and shopping in surrounding areas.除餐饮行业外，今年夏季，多家景区延长开放时间，并升级夜间旅游产品，以满足游客多样化需求。这不仅推动景区门票收入增长，还带动了周边餐饮、住宿、购物等关联业态的发展。The government has encouraged more industry players to actively develop the night tourism economy.政府也积极鼓励更多市场主体参与夜间旅游经济发展。According to a guideline issued earlier this year by the State Council, China's Cabinet, the holding of more nighttime activities such as folk performances, lantern fairs, temple fairs, and light and shadow shows has been encouraged, and different regions could develop water night tours based on local conditions.今年早些时候，国务院印发的指导意见明确，鼓励举办民俗展演、灯会、庙会、光影秀等夜间活动，各地可结合实际发展水上夜游项目。In addition, the government will support the upgrading and renovation of lighting services at night in commercial areas, and the optimization of support facilities such as parking lots and public transportation, according to the document.意见还提出，将支持商业街区夜间照明设施升级改造，优化停车场、公共交通等配套设施。In Guiyang, Southwest China's Guizhou province, a three-day international kite festival that included nighttime events attracted more than 163,000 tourists in July, netting tourism revenue of over 60 million yuan, according to the local government.据贵州省贵阳市政府消息，今年7 月举办的为期三天的国际风筝节（含夜间活动），吸引游客超 16.3 万人次，实现旅游收入超 6000 万元。Night markets, roadside concerts in parks, trunk markets and other nighttime consumption scenes were attractive to tourists.夜市、公园路边音乐会、后备箱集市等夜间消费场景，对游客具有很强的吸引力。"This type of nighttime cultural tourism model, with feature activities as its core, gathers popularity and forms a consumption loop, and has become an effective way to boost the nighttime economy," said Mu Qianyi, an analyst of LeadLeo Research Institute, a market research provider based in Shanghai.“这种以特色活动为核心的夜间文旅模式，能聚集人气、形成消费闭环，已成为拉动夜间经济的有效方式。” 上海市场研究机构头豹研究院分析师穆芊伊说。Mu added that new technologies and scenarios such as drone light shows at night will help enrich the experiences of tourists. The improvement in the quality of scenes naturally enhances the attractiveness and vitality of nighttime cultural tourism, and could help inject new impetus into economic growth.穆芊伊补充道，夜间无人机灯光秀等新技术、新场景，将进一步丰富游客体验。消费场景品质的提升，自然会增强夜间文旅的吸引力与活力，为经济增长注入新动力。Particularly, Shanghai has been developing a booming nighttime economy, and the city's after-dark economy index has maintained the top position in the country for five consecutive years. This year, it has been followed by Guangzhou, Guangdong province, and Chengdu, Sichuan province, said Rising Lab, a city-oriented big data platform of Yicai Media Group.值得关注的是，上海夜间经济持续繁荣。第一财经传媒集团旗下城市大数据平台“第一财经研究院” 数据显示，上海夜间经济指数已连续五年位居全国首位，今年紧随其后的是广东广州与四川成都。In Shanghai, nighttime lighting covered 75 percent of the city's area last year, and nighttime public transportation covered 1,975 square kilometers, which significantly helped to improve the local nighttime consumption environment, the platform found.该平台还发现，去年上海夜间照明覆盖面积占全市面积的75%，夜间公共交通覆盖范围达 1975 平方公里，这一配套设施的完善显著改善了当地夜间消费环境。
Luke Thomas and Brian Campbell are live in the studio to break down the biggest news coming out of UFC Shanghai. First up, Johnny Walker rallied to stop Zhang Mingyang in the light heavyweight main event. At 33, did Walker show you any legitimate signs that the best run of his career could be right around the corner? The UFC Shanghai co-main featured Aljamain Sterling shutting out Brian Ortega. With a 2-1 record since moving up to 145 pounds, does Sterling have any leverage at all to ask for a title shot following this performance? In the UFC Shanghai undercard, Sergei Pavlovich outpointed Waldo Cortes-Acosta to keep pace near the top of the heavyweight rankings. Given the extreme lack of depth in the division, is there still one more run to a UFC title shot in the card for Pavlovich moving forward?See omnystudio.com/listener for privacy information.
MERCH IS HERE: https://storyofthefight.etsy.comALERT: Next week you are welcome to join us LIVE on our YouTube Channel at 9am PST/11am CST if you wanna comment and laugh along with Will, Miro, and Rich! Otherwise, hit us up any way you like including by email to have your questions answered in our mailbag episode! Please leave a rating and a review along with a subscription, and check out our YouTube channel to like & subscribe!Video Episode in Full: https://www.youtube.com/watch?v=QxuLM5OTQPshttps://Instagram.com/StoryoftheFighthttps://Twitter.com/StoryoftheFighthttps://Twitch.tv/storyofthefightTikTok: @StoryoftheFightFacebook Group: https://m.facebook.com/home.php#!/groups/903248290491045?group_view_referrer=search---00:00:00 - Welcome & Intros UFC Shanghai 00:02:00 - Johnny Walker vs. Mingyang Zhang 00:08:17 - Aljamain Sterling vs. Brian Ortega 00:19:27 - Taiyilake Nueraji vs. Kiefer Crosbie Prelims00:27:02 - Charles Johnson vs. Lone'er Kavanagh 00:32:55 - Kyle Daukaus vs. Michel Pereira 00:37:17 - Yizha vs. Westin Wilson 00:40:12 - Uran Satybaldiev vs. Diyar Nurgozhay 00:47:30 - Administrative Details/Next Episode Preview/Outro #UFCShanghai #JohnnyWalker #AljamainSterling
In the latest edition of the MMAOB Daily Podcast, host Adam Martin and co-host Big Marcel recap UFC Shanghai: Walker vs. Zhang. Subscribe and watch the LIVE podcast on YouTube.Topics of discussion in today's MMAOB Daily Podcast episode:UFC Shanghai RecapJohnny Walker knocks out Zhang MingyangAljamain Sterling decisions Brian OrtegaDWCS 78 RecapDWCS 79 PreviewDownload the audio version of the MMAOB Daily Podcast at the following links:Subscribe to the show on Apple Podcasts: https://apple.co/2BNSmSDFollow the show on Spotify: https://open.spotify.com/show/559xahM8ASjTwpz7bzUOaUSubscribe to the podcast on Google Podcasts: https://www.google.com/podcasts?feed=aHR0cHM6Ly9hbmNob3IuZm0vcy9mYTA4MGU4L3BvZGNhc3QvcnNzSubscribe to the podcast on Anchor: https://anchor.fm/adam-martin45
In this JCO Article Insights episode, Dr. Joseph Matthew interviews authors Dr. Yang Zhang and Dr. Haiquan Chen about their recently published JCO article, "Phase III Study of Mediastinal Lymph Node Dissection for Ground Glass Opacity–Dominant Lung Adenocarcinoma" TRANSCRIPT Joseph Mathew: Welcome to the Journal of Clinical Oncology Article Insights episode for the August issue of the JCO. This is Joseph Mathew, editorial fellow for JCO, and today, it is my pleasure to have with us Dr. Haiquan Chen and Dr. Yang Zhang, authors of the recently published manuscript, "Phase 3 Study of Mediastinal Lymph Node Dissection for Ground-Glass Opacity-Dominant Lung Adenocarcinoma," which we will be discussing today. Dr. Chen is the Director of the Institute of Thoracic Oncology at Fudan University and the Chief of Thoracic Surgery at Fudan University Shanghai Cancer Center, where he is also the Head of Thoracic Oncology MDT and the Director of the Lung Cancer Center. Dr. Chen is a surgeon-scientist and a pioneer in developing individualized surgical strategies for early-stage non-small cell lung cancer. Dr. Zhang is a surgical oncologist and a member of the team which Dr. Chen leads at the Fudan University Shanghai Cancer Center. Welcome Dr. Chen and Dr. Zhang. Thank you very much for accepting our invitation and joining us today as part of this podcast episode. To summarize the salient points, this study presented the interim analysis of a multi-center, open-label, non-inferiority, randomized controlled trial investigating the necessity of systematic mediastinal lymph node dissection at the time of segmentectomy or lobectomy in patients with clinical stage T1N0M0 ground-glass opacity-dominant invasive lung adenocarcinoma, as defined by a consolidation-to-tumor ratio of 0.5 or less on thin-section computed tomography and a maximum tumor diameter of 3 cm or less. Eligible participants with intraoperatively confirmed invasive adenocarcinoma on frozen section analysis were randomized to either the systematic mediastinal lymph node dissection arm or to no mediastinal lymph node dissection. In the latter experimental group, mediastinal lymph nodes comprising the N2 nodal stations were not dissected, and the hilar nodes were variably addressed at the discretion of the operating surgeon. The primary endpoint of the trial was disease-free survival at 3 years. Secondary endpoints included perioperative outcomes, the status of lymph node metastasis in the systemic lymph node dissection arm, and 3-year overall survival. Before the trial reached its accrual target, a pre-planned interim safety analysis set for the time point when enrollment reached 300 patients was performed. It was noted that while none of the patients in either arm had nodal metastasis on postoperative pathological evaluation, lymph node dissection-related intraoperative and postoperative complications were more commonly observed in the systematic lymph node dissection arm, including one life-threatening episode of massive bleeding. Since this met the predefined criteria for trial termination, and in accordance with the principle of non-maleficence, further recruitment was stopped and the trial terminated. Although the 3-year disease-free survival and the overall survival for the enrolled patients were comparable, operative outcomes, including the duration of surgery, blood loss, chest tube duration, length of postoperative stay, and the rate of clinically significant complications, were significantly lower in the experimental arm compared with the systematic lymph node dissection group. The authors concluded that for well-selected patients, mediastinal nodal dissection could be omitted without adversely affecting oncological outcomes, representing a significant shift in current surgical practice, given that guidelines the world over recommend systematic lymph node dissection or sampling for all invasive lung cancers. In summary, this study addressed a clinically relevant question with regard to the extent of nodal dissection, especially in the light of recent evidence recommending less extensive parenchymal dissections for early-stage non-small cell lung cancer, with the findings suggesting that invasive lung adenocarcinoma associated with ground-glass opacities of consolidation-to-tumor ratio up to 0.5 was an excellent predictor of tumor biology, and in clinical T1N0M0 lesions, a reliable predictor of negative mediastinal lymph node involvement. So Dr. Chen and Dr. Zhang, could you tell us some more about what led you to do this research and the challenges which you faced while recruiting patients for this trial? Dr. Yang Zhang: Dr. Mathew, thank you for your summary. The current clinical guidelines recommend systematic lymph node dissection or sampling for every patient with early-stage lung cancer, regardless of their lymph node status. And in our clinical practice, we observe that this procedure causes a lot of surgical complications including chylothorax and recurrent laryngeal nerve injury. Furthermore, dissecting the tumor-draining lymph nodes actually may potentially damage the body's anti-tumor immunity. So, Dr. Chen proposed the concept of selective lymph node dissection, which we aimed to dissect the metastatic lymph nodes, while at the same time we try to preserve as many uninvolved lymph nodes as possible. So previously, we have conducted a series of retrospective studies to identify reliable predictors of nodal negative status in certain mediastinal zones, and we have performed a prospective observational phase 2 clinical trial to validate that the six criteria we proposed are 100% in predicting node-negative status. And this forms the basis for our phase 3 clinical trial. Dr. Haiquan Chen: This trial is only one of the series of trials. The meaning of this trial you already said. And for a long time, from the surgeon's point of view, we considered minimally invasive surgery. It minimizes the size of the incision and minimizes the number of the holes we made. So, the true and the high-impact of minimally invasive, we make a concept of minimal dissection, that means organ-level minimally invasive. So we proposed the concept of minimally invasive 3.0, that means minimal incision, minimal dissection (that means organ-level minimal), and systemic minimally invasive. So at first, we judged from the point of minimally invasive surgery. As long as immunotherapy is widely used in the clinical practice, we know immunotherapy, that means you use drugs to stimulate and activate the lymph node site. If we dissect all the metastatic lymph nodes, cut them out, how can we restimulate that lymph node site? So, from minimally invasive trauma and second, from the functional aspect, to try to save as many uninvolved lymph nodes as possible. Joseph Mathew: Thank you, Dr. Chen. That's a very interesting concept that you alluded to even in the discussion of this paper, as to the potential role of the non-metastatic lymph nodes as immune reservoirs. So, coming back to this paper, were there any challenges which you faced while recruiting patients for this trial? Dr. Haiquan Chen: The criteria is very clear. That means invasive adenocarcinoma, that means most of the centimeter is 3.0 centimeter and also CTR ratio less than 0.5. And we can see that, you know, we did study about that. Even the invasive component of the subsolid nodule, it's bigger than the solid part. That means even the pure GGO, we can find out that there's still some invasive component. From this point of view, pure GGO and subsolid GGO, from this part of invasive carcinoma, that means it's a special clinical subtype that we, from retrospective study and also prospective study, we find out this group of patients, there are no mediastinal lymph node metastasis. So I think it's very important for this kind of group that we can avoid doing the mediastinal lymph node dissection. And we can do organ-level minimally invasive surgery. And also, we try to keep the patient's immune function as normal as possible. Dr. Yang Zhang: Well, Dr. Mathew, we believe that the biggest challenge when we are enrolling these patients is that there needs to be a paradigm shift in the mind because systematic lymph node dissection has long been the standard of care. And some patients may misunderstand. Before the enrollment, we have to give them informed consent, but if the patient hears that they may be enrolled in the no-lymph-node-dissection group, they may feel that they do not receive radical, curative-intent surgery. So we believe, as Dr. Chen has said, after the release of our results, the no-lymph-node dissection may be incorporated in the future guideline for those patients without lymph node involvement, we can just omit the lymph node dissection. Joseph Mathew: The study described two pre-planned interim points during the course of subject enrollment when the data was analyzed. So Dr. Chen and Dr. Zhang, could you please explain a little more about these two interim points of analysis that were planned and the rationale behind it? Dr. Yang Zhang: When conducting this trial, we have two concerns. One is if there is any lymph node metastasis, there may be omission of metastatic lymph nodes not dissected in the no-lymph-node-dissection group. And there is another concern is that if all these lymph nodes are uninvolved, then dissecting these lymph nodes may cause life-threatening complications. So, we set the 150 interim analysis to ensure that there is no lymph node involvement in this group. And the other early termination criteria is set because if there is no lymph node involvement found in both groups, then a severe complication which is life-threatening is unacceptable because it threatens the patient's safety. Joseph Mathew: So, although you did briefly allude to in the paper, what was the basis for selecting DFS as the primary endpoint when the objective of this trial was to assess nodal involvement in this subset of tumors? Dr. Yang Zhang: Well, previously, we have done a series of retrospective studies and one prospective phase 2 trial. And in these studies, we have identified that GGO-dominant lung adenocarcinoma, even if it's invasive, it has no lymph node involvement. So this phase 3 trial was primarily designed to compare the survival outcomes. But as the trial went on, as Dr. Chen has concerns that if the patients have no lymph node metastasis at all, it may be unfair to dissect the lymph nodes for patients enrolled in the systematic lymph node dissection group. So there is one life-threatening complication that happens due to dissecting the lymph nodes and injury to the superior vena cava, which leads to massive bleeding. It is at this point that we decided to terminate this trial for patient safety concerns. Joseph Mathew: Yeah, that's a very fair point. So you made sure that the ethical considerations were kept intact. So another point was, there was a mention in the study of the historical data from your institution suggesting a 3-year disease-free survival of 96.6% for patients with clinical T1N0M0 ground-glass opacity-dominant invasive lung adenocarcinoma. So could you please elaborate on the patterns of recurrence which you noted for this group of patients who had developed a recurrence? Dr. Haiquan Chen: Yeah, I think over 90% 3-year DFS, that's the least. From our retrospective data for this kind of group of patients, their DFS is so good. To the best of my knowledge, almost 100%. So this is very conservative, 94, 90% is very conservative. I think the trial eventually would have been positive. It's a special clinical subtype, even for invasive adenocarcinoma, their prognosis is much better than the other type of invasive adenocarcinoma. Joseph Mathew: So this question may be slightly outside the purview of this study, but in your clinical practice, would you advocate either segmentectomy or lobectomy for all patients meeting the trial criteria, that is, lesions measuring 3 cm or less with a CTR of up to 0.5? Or is there a subgroup of patients you would recommend a wedge dissection for? Dr. Haiquan Chen: I think CTR ratio is one parameter and also the location is another very important parameter. So we put it together to make a decision, the patient should do a lobectomy or segmentectomy. Even for an ongoing trial, for even the patient, invasive adenocarcinoma, we can do in the right location, even wedge, it can achieve enough negative margin in the ongoing trial to verify the comparable result for the patient, we can do the wedge dissection. So not just the CTR ratio, that's not the only parameter to make a decision on what kind of procedure we'll do. Joseph Mathew: Yeah, great point, Dr. Chen. So from my perspective, this study was a well-designed, randomized control trial based on a relevant and clinically valid research question. So what, in your opinion, are the main strong points of this study? Dr. Yang Zhang: We believe that this study represents the first randomized clinical trial published, yet, regarding the topic of selective lymph node dissection. It basically offers the highest level of evidence. We believe our results should be incorporated in the future clinical guideline. Joseph Mathew: Given the increasing incidence of these lesions, I think it was- a randomized control trial in this arena was much awaited. And the other point is that GGO-dominant lung adenocarcinomas, the specific clinical guidelines are not very clear. So I think your study brought out that lymph node dissection for these tumors which satisfy the eligibility criteria could be omitted safely. Important consideration here is that the conclusions of the trial were based on an interim analysis, and this analysis was not planned for an early assessment of the primary endpoint. In other words, the study was not adequately powered to detect a significant difference in DFS at 3 years. So Dr. Chen and Dr. Zhang, what do you perceive are the most important limitations of this study which you feel should be addressed in future research? Dr. Haiquan Chen: So the surgery now is more individualized. I think the surgery from the last two decades, from the maximum tolerable intervention to minimum effective treatment, there's a big shift. So I think that the consensus, we can preserve normal lung parenchyma as much as possible. For the lymph nodes, I think that the big shift, we should shift it to keep as many as uninvolved lymph nodes as possible. So that's very important, not just to reduce the intraoperative trauma, but also to keep the immune environment as normal as possible. Joseph Mathew: Another point was the limited long-term follow-up data to determine the actual impact of omitting lymph node dissection on local-regional disease control. So is any future follow-up planned to assess the long-term survival outcomes for the 302 patients which were enrolled in this trial? Dr. Haiquan Chen: Yeah, I think that's very important for us. This trial we terminated just because if we keep the trial going, it's unfair for the mediastinal lymph node dissection group. We tried to just stop here, and we shifted to the single-arm trial. So, 2 or 3 years, this trial and another trial, they will give our final result to demonstrate more if selective mediastinal lymph nodes have a better result than ever before. And we will support the mediastinal lymph node dissection. That's one way. And the American College just asked me, how can we put this policy into clinical practice in the United States? Because most of the patients they meet have solid tumors. So we have another trial, try to figure out how we can make sure before and intraoperative the lymph node status is negative or positive, and then we can solve that problem and put this policy into clinical practice in the Western society. Joseph Mathew: Great. So that would be something we should all be looking forward to. So, this brings me to the final point of discussion on future research in this field. Dr. Chen, you commented in the paper that future studies should focus on improving the reproducibility of CTR evaluation. What are your thoughts on this subject? Dr. Haiquan Chen: The CTR ratio, the concept from the JCOG 0201, just a concept from that prospective study, the phase 2 study, only subgroup analysis they give the concept of CTR ratio and the diameter. How can we reproduce? In our group and also I believe in Japan and in China, in Korea, and in our daily practice, I think CTR ratio is not a big issue. There are two very important things. One, you make sure the CTR ratio, not in a common CAT scan, but in a high-resolution CAT scan. So the imaging, that's the first thing. And the second, not from the single section and a two or three section, you make sure that your calculation is accurate. That's not just the single section, you make sure that you got the conclusion, the CTR ratio is the same number. We make sure that totally we, from the top to the bottom of the whole lesion, we make sure that the CTR ratio is accurate. Joseph Mathew: Thank you, Dr. Chen. I think that would involve training our radiologists also to be aware of the CTR ratio and how it should be interpreted. So another very interesting concept which you had alluded to in the discussion was the potential role of non-metastatic lymph nodes as immune reservoirs. So how do you think we could preserve these nodes and do you think sentinel node biopsies would play a role in future? Dr. Yang Zhang: Actually, Dr. Chen has also led some basic research on this topic. We are investigating the immunological role of the tumor-draining lymph nodes. And our preliminary results have already shown that the tumor-draining lymph nodes of lung cancer, especially those uninvolved lymph nodes, have a vital role in the anti-tumor immunity and also effective response to the current anti-PD-1 immunotherapy. In the future, we believe that by incorporating our clinical evidence and those findings from our basic research, we will be able to provide very strong rationale to support selective lymph node dissection. Joseph Mathew: So lastly, what are the questions that still remain to be answered and what do you perceive as the next step in this field? Dr. Haiquan Chen: I think for the lung cancer surgery, especially for the cT1N0M0, they are more individualized. We can, based on the patient, the location, the CTR ratio, we can do wedge dissection, or segmentectomy, or lobectomy. For the lymph node dissection, we can do no mediastinal lymph node dissection or selective, only to dissect the positive one, or we have to do the systemic mediastinal lymph node dissection. So we can see there are too many combinations. So in the near future, for the surgery perspective, we have it more individualized. In the future, we just try to make sure we do not cut as many as possible. We just make sure that we can avoid over-diagnosis or overtreatment or over-dissected. I think that in the near future, that goal will come true. Joseph Mathew: That's a great point, Dr. Chen. So that would be something also for the thoracic oncology community to work towards. This wraps up today's episode of JCO Article Insights. Dr. Chen and Dr. Zhang, thank you very much for taking the time to join us today in what has been a very insightful session. Dr. Haiquan Chen: Thank you. Dr. Yang Zhang: Thanks. Joseph Mathew: To our audience, thank you for listening. Please stay tuned for more interviews and articles, summaries, and be sure to leave us your comments and ratings. For more podcasts and episodes from ASCO, please visit asco.org/podcasts. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.
In this episode of Yet Another Value Podcast, host Andrew Walker is joined by Jingshu from Guinea Value to discuss New Oriental Education (ticker: EDU), a Chinese education services firm. They explore the company's dramatic fall in 2021 following regulatory crackdowns, its surprising rebound, and its resilience in the face of industry headwinds. Jingshu shares rare firsthand insights from his own experience founding a similar business, giving unique context to New Oriental's position in the market. Topics range from working capital dynamics and regulatory shifts to capital allocation and AI's impact on education. Tune in for an in-depth look at one of China's most compelling turnaround stories.__________________________________________________________[00:00:00] Andrew introduces podcast and guest[00:02:16] Jingshu greets and intro begins[00:02:55] New Oriental company history overview[00:05:02] Reasons Andrew invited Jingshu[00:05:32] Jingshu's personal edu background[00:09:41] China edu sector decline insights[00:10:24] Market misunderstanding and tail risks[00:16:03] Discussion of regulatory risk[00:22:25] Cash position and asset value[00:25:43] Livestream business background[00:27:26] Capital return strategy discussion[00:33:57] Michael's conservative cash mindset[00:38:28] AI disruption and edtech impact[00:43:19] Challenges of AI competition[00:46:06] Superstar teacher dynamics[00:48:44] Andrew closes the episodeLinks:Yet Another Value Blog: https://www.yetanothervalueblog.com See our legal disclaimer here: https://www.yetanothervalueblog.com/p/legal-and-disclaimer
In this episode of Bring the Pain, I reviewed UFC Shanghai, which featured Walker vs. Zhang in the main event. I talked about the Fight Club of Pain and how we nailed more big bets and parlays this week in which we slayed the sportsbooks while sleeping. After that, I talked about the break this week before coming back on Thursday for UFC Paris, which has Imavov vs. Borrahlo, as the main event. That also will be the opening game for the NFL, so expect a Showdown Slate lineup for Thursday night football every single week. That's how we do it at Dr. Roto. Have a great day, everyone, and may the fights be with you.Thank you for the support and contributions all of you make for my podcasts and articles each week. Y'all the real #Painbringers!Follow me at....*Facebookhttps://www.facebook.com/Bring...*Twitterhttps://twitter.com/HeatOverid...*Spreaker Podcastshttps://spreaker.page.link/VS5...*Dr Roto Sports Websitehttps://drroto.com/author/robe...*You Tubehttps://youtube.com/@Heat00veride05?si=cVb49FjQD-Y6fKjT*Apple Podcastshttps://podcasts.apple.com/us/...*Spotify Podcastshttps://open.spotify.com/show/...*Podchaser Podcastshttps://www.podchaser.com/podc...*Iheart Podcastshttps://www.iheart.com/podcast...Become a supporter of this podcast: https://www.spreaker.com/podcast/bring-the-pain--3659369/support.
Angelo from We Want Picks recaps and reacts to every single fight from UFC Shanghai: Walker vs. Zhang!
The UFC's return to Shanghai is officially in the books, and the event ended with Johnny Walker pulling off a big upset in the main event, and a former bantamweight champion making a case for a title shot in a second division. Where do both fighters go from their big wins? Following Saturday's UFC Shanghai event, MMA Fighting's Mike Heck and E. Casey Leydon react to the card, Walker's stunning second-round TKO win over Zhang Mingyang, Walker's callout of Jan Blachowicz, and discuss what could be next for Zhang after suffering his first UFC loss. Additionally, topics include Aljamain Sterling's lopsided win over Brian Ortega in the co-main event, where Sterling is in the title conversation, if we just saw Ortega's final fight in the UFC, other standout moments, and much more. Follow Mike Heck: @m_heckjr Follow E. Casey Leydon: @ekc Subscribe: http://goo.gl/dYpsgH Check out our full video catalog: http://goo.gl/u8VvLi Visit our playlists: http://goo.gl/eFhsvM Like MMAF on Facebook: http://goo.gl/uhdg7Z Follow on Twitter: http://goo.gl/nOATUI Read More: http://www.mmafighting.com Learn more about your ad choices. Visit podcastchoices.com/adchoices
The UFC's return to Shanghai is officially in the books, and the event ended with Johnny Walker pulling off a big upset in the main event, and a former bantamweight champion making a case for a title shot in a second division. Where do both fighters go from their big wins? Following Saturday's UFC Shanghai event, MMA Fighting's Mike Heck and E. Casey Leydon react to the card, Walker's stunning second-round TKO win over Zhang Mingyang, Walker's callout of Jan Blachowicz, and discuss what could be next for Zhang after suffering his first UFC loss. Additionally, topics include Aljamain Sterling's lopsided win over Brian Ortega in the co-main event, where Sterling is in the title conversation, if we just saw Ortega's final fight in the UFC, other standout moments, and much more. Follow Mike Heck: @m_heckjr Follow E. Casey Leydon: @ekc Subscribe: http://goo.gl/dYpsgH Check out our full video catalog: http://goo.gl/u8VvLi Visit our playlists: http://goo.gl/eFhsvM Like MMAF on Facebook: http://goo.gl/uhdg7Z Follow on Twitter: http://goo.gl/nOATUI Read More: http://www.mmafighting.com Learn more about your ad choices. Visit podcastchoices.com/adchoices
The UFC's return to Shanghai is officially in the books, and the event ended with Johnny Walker pulling off a big upset in the main event, and a former bantamweight champion making a case for a title shot in a second division. Where do both fighters go from their big wins? Following Saturday's UFC Shanghai event, MMA Fighting's Mike Heck and E. Casey Leydon react to the card, Walker's stunning second-round TKO win over Zhang Mingyang, Walker's callout of Jan Blachowicz, and discuss what could be next for Zhang after suffering his first UFC loss. Additionally, topics include Aljamain Sterling's lopsided win over Brian Ortega in the co-main event, where Sterling is in the title conversation, if we just saw Ortega's final fight in the UFC, other standout moments, and much more. Follow Mike Heck: @m_heckjr Follow E. Casey Leydon: @ekc Subscribe: http://goo.gl/dYpsgH Check out our full video catalog: http://goo.gl/u8VvLi Visit our playlists: http://goo.gl/eFhsvM Like MMAF on Facebook: http://goo.gl/uhdg7Z Follow on Twitter: http://goo.gl/nOATUI Read More: http://www.mmafighting.com Learn more about your ad choices. Visit podcastchoices.com/adchoices
In this episode of Bring the Pain, Dan and I are open in the Fight Club of Pain, ready to help you slay the competition again. After a solid UFC 319 card, it left us hungry for more, so we diving back into the sportsbooks looking for those juicy bets that will help us cash this week. On top of that, we'll be giving out two DFS lineups and some parlays that should help us show the slates who the boss is. That means you'll want to buckle up because this ride could become bumpy. Have a great day, everyone, and may the fights be with you. Thank you for the support and contributions all of you make for my podcasts and articles each week. Y'all the real #Painbringers! Follow me at.... *Facebookhttps://www.facebook.com/Bring... *Twitterhttps://twitter.com/HeatOverid... *Spreaker Podcastshttps://spreaker.page.link/VS5... *Dr Roto Sports Websitehttps://drroto.com/author/robe... *You Tubehttps://youtube.com/@Heat00veride05?si=cVb49FjQD-Y6fKjT *Apple Podcastshttps://podcasts.apple.com/us/... *Spotify Podcastshttps://open.spotify.com/show/... *Podchaser Podcastshttps://www.podchaser.com/podc... *Iheart Podcastshttps://www.iheart.com/podcast... #ufc #mma #fighttheory #drroto #bringthepain #fightclubofpain #ufcshanghai #ufcsheriffs #parlayofpain #dfs #betting #propbets #freelineups #freebets #soupcanoftheweek #fivetasticpicks #mainevent #fantasysportsBecome a supporter of this podcast: https://www.spreaker.com/podcast/bring-the-pain--3659369/support.
LT and BC are back on a Friday to preview UFC Shanghai: Walker vs. Zhang, Ortega vs. Sterling. Plus, RDR vs. Fluffy middleweight tilt headlines stacked UFC Vancouver card. And in boxing news, Jake Paul - Gervonta Davis exhibition bout announced for Nov. 14 on Netflix. Join Luke Thomas, Brian Campbell and the entire Morning Kombat crew to talk all things combat sports heading into the weekend!See omnystudio.com/listener for privacy information.
UFC Shanghai goes down in the early morning hours on Saturday, and during Thursday night's weigh-ins, Brian Ortega appeared to be in rough shape ahead of his pivotal matchup with former bantamweight champ Aljamain Sterling. While reports stated the fight was off, it will indeed take place at a catchweight of 153 pounds, despite Ortega looking horrible during his final staredown with Sterling. Should this fight go on? Ahead of this weekend's UFC Fight Night event, MMA Fighting's Jed Meshew and Mike Heck preview the card, react to Ortega's weigh-in drama, and discuss the fight with Sterling. Additionally, they talk the light heavyweight main event between Zhang Mingyang and Johnny Walker, the stakes for the division that needs as much excitement as possible, the heavyweight featured bout between Sergei Pavlovich and Waldo Cortes-Acosta, and much more. Follow Mike Heck: @m_heckjr Follow Jed Meshew: @JedKMeshew Subscribe: http://goo.gl/dYpsgH Check out our full video catalog: http://goo.gl/u8VvLi Visit our playlists: http://goo.gl/eFhsvM Like MMAF on Facebook: http://goo.gl/uhdg7Z Follow on Twitter: http://goo.gl/nOATUI Read More: http://www.mmafighting.com Learn more about your ad choices. Visit podcastchoices.com/adchoices
On Episode 3,594, the guys had a UFC and PFL card to cover. They also had the main event fighters from UFC China, Johnny Walker and Zhang Mingyang.
UFC Shanghai goes down in the early morning hours on Saturday, and during Thursday night's weigh-ins, Brian Ortega appeared to be in rough shape ahead of his pivotal matchup with former bantamweight champ Aljamain Sterling. While reports stated the fight was off, it will indeed take place at a catchweight of 153 pounds, despite Ortega looking horrible during his final staredown with Sterling. Should this fight go on? Ahead of this weekend's UFC Fight Night event, MMA Fighting's Jed Meshew and Mike Heck preview the card, react to Ortega's weigh-in drama, and discuss the fight with Sterling. Additionally, they talk the light heavyweight main event between Zhang Mingyang and Johnny Walker, the stakes for the division that needs as much excitement as possible, the heavyweight featured bout between Sergei Pavlovich and Waldo Cortes-Acosta, and much more. Follow Mike Heck: @m_heckjr Follow Jed Meshew: @JedKMeshew Subscribe: http://goo.gl/dYpsgH Check out our full video catalog: http://goo.gl/u8VvLi Visit our playlists: http://goo.gl/eFhsvM Like MMAF on Facebook: http://goo.gl/uhdg7Z Follow on Twitter: http://goo.gl/nOATUI Read More: http://www.mmafighting.com Learn more about your ad choices. Visit podcastchoices.com/adchoices
UFC Shanghai goes down in the early morning hours on Saturday, and during Thursday night's weigh-ins, Brian Ortega appeared to be in rough shape ahead of his pivotal matchup with former bantamweight champ Aljamain Sterling. While reports stated the fight was off, it will indeed take place at a catchweight of 153 pounds, despite Ortega looking horrible during his final staredown with Sterling. Should this fight go on? Ahead of this weekend's UFC Fight Night event, MMA Fighting's Jed Meshew and Mike Heck preview the card, react to Ortega's weigh-in drama, and discuss the fight with Sterling. Additionally, they talk the light heavyweight main event between Zhang Mingyang and Johnny Walker, the stakes for the division that needs as much excitement as possible, the heavyweight featured bout between Sergei Pavlovich and Waldo Cortes-Acosta, and much more. Follow Mike Heck: @m_heckjr Follow Jed Meshew: @JedKMeshew Subscribe: http://goo.gl/dYpsgH Check out our full video catalog: http://goo.gl/u8VvLi Visit our playlists: http://goo.gl/eFhsvM Like MMAF on Facebook: http://goo.gl/uhdg7Z Follow on Twitter: http://goo.gl/nOATUI Read More: http://www.mmafighting.com Learn more about your ad choices. Visit podcastchoices.com/adchoices
Watch the episode on YouTube - https://www.youtube.com/watch?v=8k-PAF2WmRkHead to Buffalo Wild Wings Philadelphia location 9701 Roosevelt Blvd, Philadelphia, PA 19114 and mention The BradyBagz Show or SteadyPicks for 10% off! Stop in to watch the games, sweat some bets, and enjoy some food and drinks!Follow The BradyBagz Show On Instagram: https://www.instagram.com/thebradybagzshow/Learn more about SteadyPicks: https://www.steadypicks.com/
Big shoutout to Pepe for joining us on the pod! Follow him on IG:https://www.instagram.com/guruvianIf you want to watch our prelim breakdowns, head over to the Patreon and sign up! You'll also get all of our favorite picks of the week, as well as access to our ever growing, ever entertaining Discord!https://www.patreon.com/mmabreakdownsandbetsFollow us on IG at: http://instagram.com/santinodefrancohttp://instagram.com/brandanolivasAlso available on iTunes and Spotify.Support the show
The UFC is headed back to China. This Saturday, the UFC returns to The Middle Kingdom with UFC Shanghai, headlined by a light heavyweight contest between Johnny Walker and Zhang Mingyang, and No Bets Barred is here to break it all down. This week, host Jed Meshew flies solo as he dives into UFC Shanghai. Topics discussed include his disastrous showing at UFC 319, The Mountain Tiger's chances to run over Walker, the five-round co-main event between Brian Ortega and Aljamain Sterling, the featured heavyweight bout between Sergei Pavlovich and Waldo Cortes-Acosta, the latest update on The Climb, and more. Tune in for episode 136 of No Bets Barred. Follow Jed Meshew: @JedKMeshew Subscribe to MMA Fighting Check out our full video catalog Like MMA Fighting on Facebook Follow on Twitter Read More: http://www.mmafighting.com Learn more about your ad choices. Visit podcastchoices.com/adchoices
Dricus Du Plessis is back with his funniest performance yet! Talking about how MVP is the only Bellator/PFL guy currently killing it in the UFC, plus Loopy Godinez, Lone'er Kavanagh, and more in our latest bonus episode: https://www.patreon.com/heavyhands Predatory instinct: how Max Holloway attacks - read my latest breakdown on Substack: https://open.substack.com/pub/facepunching/p/predatory-instinct-how-max-holloway?r=evbq&utm_campaign=post&utm_medium=web&showWelcomeOnShare=false Heavy Hands merch: https://www.redbubble.com/shop/ap/64577943?asc=u CONTENTS: 00:00 Intro 6:28 Du Plessis vs Chimaev 41:53 Murphy vs Pico 50:48 Prates vs Neal 1:01:07 Walker vs Zhang 1:05:48 Ortega vs Sterling
The UFC is headed back to China. This Saturday, the UFC returns to The Middle Kingdom with UFC Shanghai, headlined by a light heavyweight contest between Johnny Walker and Zhang Mingyang, and No Bets Barred is here to break it all down. This week, host Jed Meshew flies solo as he dives into UFC Shanghai. Topics discussed include his disastrous showing at UFC 319, The Mountain Tiger's chances to run over Walker, the five-round co-main event between Brian Ortega and Aljamain Sterling, the featured heavyweight bout between Sergei Pavlovich and Waldo Cortes-Acosta, the latest update on The Climb, and more. Tune in for episode 136 of No Bets Barred. Follow Jed Meshew: @JedKMeshew Subscribe to MMA Fighting Check out our full video catalog Like MMA Fighting on Facebook Follow on Twitter Read More: http://www.mmafighting.com Learn more about your ad choices. Visit podcastchoices.com/adchoices
Can Johnny Walker withstand the pure power of Mingyang Zhang? UFC betting expert Kyle Anthony breaks down everything you need to know about UFC Fight Night taking place in Shanghai, China!Introduction 00:00Mingyang Zhang vs Johnny Walker 00:25Michel Pereira vs Kyle Daukaus 03:27Lone'er Kavanagh vs Charles Johnson 06:53Rongzhu vs Austin Hubbard 09:30
In this episode of the Epigenetics Podcast, we talked with Luca Magnani from Institute of Cancer Research and UNIMI in Milan about his work on epigenetic mechanisms of drug resistance and cancer cell dormancy in breast cancer. We start the interview by putting our focus on his significant contributions to the understanding of estrogen receptor-positive breast cancer. In a foundational study from 2013, Professor Magnani and his colleagues illuminated the role of genome-wide reprogramming of the chromatin landscape in conferring resistance to endocrine therapy. This research marked a departure from a purely genetic mutation paradigm, proposing instead that epigenetic modifications play a pivotal role in the development of drug resistance. A fascinating part of our conversation centers on the role of pioneer transcription factors, particularly PBX1, in regulating the estrogen receptor's transcriptional response. Professor Magnani explains how PBX1, typically associated with hematopoietic development, influences estrogen receptor activity, thereby shaping the cancer cell's fate and response to treatment. Continuing our exploration, we discuss the critical distinctions between primary and metastatic breast cancer through the lens of epigenetic reprogramming. By analyzing samples from women with breast cancer, Professor Magnani's work identifies specific enhancer usage that marks the transition to a drug-resistant state which was a breakthrough in linking epigenetic alterations to real-world patient outcomes. He emphasizes that the reliance on genetic mutations alone does not adequately explain the mechanisms of drug resistance, pushing the field to consider the epigenetic landscape more deeply. Our conversation also touches on the evolution of experimental techniques. Professor Magnani shares insights into the transition from traditional ChIP-seq methods to CUT&RUN, demonstrating the need for techniques that cater to the limited material available from clinical samples. This adaptability mirrors the dynamic nature of cancer itself, as cells continuously evolve under therapeutic pressure. As we traverse through the complexities of dormancy and reactivation in cancer cells, Professor Magnani enlightens us on the unpredictable nature of tumor behavior. He describes how cancer cells can enter dormant states and how their awakening is influenced by environmental factors, akin to an evolutionary response to stressors, thus revealing the intricate balance between survival and proliferation. In the latter part of the episode, we explore Professor Magnani's vision for the future of breast cancer research, which includes the need for better animal models that mimic human disease. His pursuit of understanding estrogen receptor behavior both in healthy and cancerous cells reflects a holistic approach to cancer biology, aiming to decipher the transition from normal tissue to malignancy. References Magnani, L., Stoeck, A., Zhang, X., Lánczky, A., Mirabella, A. C., Wang, T. L., Gyorffy, B., & Lupien, M. (2013). Genome-wide reprogramming of the chromatin landscape underlies endocrine therapy resistance in breast cancer. Proceedings of the National Academy of Sciences of the United States of America, 110(16), E1490–E1499. https://doi.org/10.1073/pnas.1219992110 Nguyen, V. T., Barozzi, I., Faronato, M., Lombardo, Y., Steel, J. H., Patel, N., Darbre, P., Castellano, L., Győrffy, B., Woodley, L., Meira, A., Patten, D. K., Vircillo, V., Periyasamy, M., Ali, S., Frige, G., Minucci, S., Coombes, R. C., & Magnani, L. (2015). Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion. Nature communications, 6, 10044. https://doi.org/10.1038/ncomms10044 Patten, D. K., Corleone, G., & Magnani, L. (2018). Chromatin Immunoprecipitation and High-Throughput Sequencing (ChIP-Seq): Tips and Tricks Regarding the Laboratory Protocol and Initial Downstream Data Analysis. Methods in molecular biology (Clifton, N.J.), 1767, 271–288. https://doi.org/10.1007/978-1-4939-7774-1_15 Related Episodes Enhancers and Chromatin Remodeling in Mammary Gland Development (Camila dos Santos) Contribution of Estrogen Receptor to Breast Cancer Progression (Jason Carroll) Circulating Epigenetic Biomarkers in Cancer (Charlotte Proudhon) Contact Epigenetics Podcast on Mastodon Epigenetics Podcast on Bluesky Dr. Stefan Dillinger on LinkedIn Active Motif on LinkedIn Active Motif on Bluesky Email: podcast@activemotif.com
The UFC is headed back to China. This Saturday, the UFC returns to The Middle Kingdom with UFC Shanghai, headlined by a light heavyweight contest between Johnny Walker and Zhang Mingyang, and No Bets Barred is here to break it all down. This week, host Jed Meshew flies solo as he dives into UFC Shanghai. Topics discussed include his disastrous showing at UFC 319, The Mountain Tiger's chances to run over Walker, the five-round co-main event between Brian Ortega and Aljamain Sterling, the featured heavyweight bout between Sergei Pavlovich and Waldo Cortes-Acosta, the latest update on The Climb, and more. Tune in for episode 136 of No Bets Barred. Follow Jed Meshew: @JedKMeshew Subscribe to MMA Fighting Check out our full video catalog Like MMA Fighting on Facebook Follow on Twitter Read More: http://www.mmafighting.com Learn more about your ad choices. Visit podcastchoices.com/adchoices
My Fintech Newsletter for more interviews and the latest insights:↪︎ https://rexsalisbury.substack.com/In this episode, Jack, founder of Airwallex, shares his journey—from working odd jobs in Australia to leading a company that rejected a $1.2B acquisition offer from Stripe and now generates close to $900M in annual revenue. Jack reveals how Airwallex evolved through three distinct phases—from FX infrastructure to a comprehensive business banking platform—serving 150,000 customers globally. We discuss pivotal moments with investors, rapid scaling, and the challenges of global money movement. Jack also shares candid views on stablecoins, go-to-market strategies—including major brand partnerships like McLaren F1 and Arsenal—and dives into Airwallex's ambitious AI plans that aim to revolutionize finance. Tune in to hear about bold decisions, lessons from near-bankruptcy, and what's next for one of fintech's fastest-growing companies.Jack Zhang: linkedin.com/in/jack-zhang-0520022200:00 - Why Airwallex turned down Stripe's $1.2B offer00:37 - Jack's journey: Odd jobs to founder01:08 - Stablecoins and global money movement: Useless or gamechanger?03:22 - Unlocking initial hypergrowth: Key customers and industries05:20 - Pivoting product: What didn't work and why07:37 - Three phases of Airwallex's growth08:58 - Building a layered business banking platform10:06 - From student magazines to diverse side businesses13:37 - Lessons from early failures and successes15:34 - Creating borderless financial infrastructure16:56 - Are stablecoins really practical for payments?19:18 - Scaling payments: Liquidity, costs, and geographies21:36 - Airwallex today: Revenue and growth stats22:23 - Market scope and expansion plans24:18 - The million-dollar meeting: Raising capital27:04 - Hardest fundraises and investor stories29:28 - Go-to-market strategy: Brand and partnerships33:25 - Investing in brand: The timing and payoff34:24 - Founder visibility: Why Jack speaks out now37:05 - Impact of storytelling on growth and hiring38:32 - Life outside Airwallex: Hobbies & balance38:44 - Expansion in the US: Offices and hiring plans40:13 - Airwallex Copilot: AI agents for autonomous finance41:42 - AI-powered products: The future of business ops42:22 - Major product launches: Full-stack billing for AI companies43:15 - Crossing $1B ARR: What's next for Airwallex44:13 - Airwallex Billing: Features, rollout, and free offer___Connect with Rex on social media:LinkedIn: https://www.linkedin.com/in/rexsalisbury/Twitter: https://twitter.com/rexsalisburyTikTok: https://www.tiktok.com/@rex.salisburyInstagram: https://www.instagram.com/rexsalisbury/
The MMA Vivisection Shows: 'Main Card Preview' & 'Prelims Card Preview'
This is a free preview of a paid episode. To hear more, visit themmadrawpodcast.substack.comUFC Shanghai is your classic mixed bag with a few good fights among a sea of regional level fodder. The main event should actually be Ortega vs. Sterling but we get why it's Walker vs. Zhang. Why Kavanagh vs. Johnson isn't on the main card is the card's greatest mystery and just seems wrong on every level. But we've come to expect oddities like these. A…
Carlo and Sean recap last weeks highly anticipated UFC 319: Du Plessis vs. Chimaev event and preview the UFC Fight Night 257: Walker vs. Zhang in China.Instagram: www.instagram.com/sean_pierre_Instagram: www.instagram.com/hapki1**MERCH!**Limited Edition MB Podcast Episode 100 TeeThe Mighty Beast Podcast "Shut Up White Belt" tee via Amazon PrimeThe Mighty Beast Podcast "Noob Aficionado" tee via Amazon PrimeThe Mighty Beast Podcast "Signature" tee via Amazon PrimeThe Mighty Beast Podcast "SHOGUN" zip up hoodie via Amazon Prime
UFC Shanghai Walker vs ZhangThe evening is headlined by a light heavyweight showdown between Brazil's *Johnny Walker* and China's rising star **Zhang Mingyang**. Walker, a former Top 15 contender, arrives on a rough patch, suffering back-to-back stoppage losses and entering this bout looking to revitalize his career. On the opposite side stands Zhang—nicknamed "Mountain Tiger"—boasting an undefeated UFC run filled exclusively with first-round finishes, including a recent brutal stoppage of veteran Anthony Smith. The fight features a classic physical mismatch: Walker possesses significant size and reach advantages (6'6", 82–82.3″ reach) compared to Zhang (6'2", ~75.5″ reach), but Zhang's aggressive style and knockout accuracy make him the betting favorite heading into Shanghai.The supporting main card also includes a mouthwatering co-main event: featherweight contenders *Brian Ortega* versus *Aljamain Sterling**, a clash of grappling pedigree and submission threats—Sterling favored for his ground control, though Ortega's resilience could make it competitive. Also penciled in are three additional bouts: **Sergei Pavlovich vs. Waldo Cortes‑Acosta* in heavyweight, projected as a potential knockout duel with Pavlovich favored; *Sumudaerji vs. Kevin Borjas* in flyweight, with technical striker Sumudaerji considered the safer pick for a decision win; and debuting Chinese welterweight** Taiyilake Nueraji vs. Kiefer Crosbie**, where Nueraji is heavily backed to win via early finish . Together, these matchups round out what promises to be an explosive and culturally significant UFC return to Shanghai. LINKTREE: https://linktr.ee/AJLetsTalkSports
UFC Fight Night: Walker vs. ZhangFollow us on X https://x.com/dontleaveitpodUse code "Judges" for 10 percent off https://www.dubby.gg/
This is a free preview of a paid episode. To hear more, visit themmadrawpodcast.substack.comUFC Shanghai is your classic mixed bag with a few good fights among a sea of regional level fodder. The main event should actually be Ortega vs. Sterling but we get why it's Walker vs. Zhang. Why Kavanagh vs. Johnson isn't on the main card is the card's greatest mystery and just seems wrong on every level. But we've come to expect oddities like these. A…
Fans of DFS MMA and DraftKings, are you ready!? Check out this week's episode of the DFS Army MMA Killshot podcast, breaking down every fight on the UFC Shanghai: Walker vs Zhang card. Sign up for a DFS Army VIP Subscription with code "SNIPER" for 10% off: https://www.dfsarmy.com/pricing
Big thank you to Jacori Teemer for being our guest on this week's show! Jacori was the 2nd person to become a 5x NY State wrestling champion. Troy Nickerson was the first. Currently, only four wrestlers have ever won five NY titles! Follow him on IG:https://www.instagram.com/jacori_beentrillIf you want to watch our prelim breakdowns, head over to the Patreon and sign up! You'll also get all of our favorite picks of the week, as well as access to our ever growing, ever entertaining Discord!https://www.patreon.com/c/mmabreakdownsandbetsFollow us on IG at: https://www.instagram.com/santinodefrancohttps://www.instagram.com/brandanolivasSupport the show
Support YDS on Patreon!This week, Zoë and Kylee tackle the carnivore diet, the internet's most extreme eating trend. From raw liver smoothies at Erewhon to shirtless influencers promising that “meat heals everything,” the carnivore diet has exploded in popularity. But what really happens when you cut out all plants and live on ribeye steaks, bacon, and bone broth?We explore the strange history of meat-only diets, from 1920s Bellevue experiments to modern influencers like Shawn Baker and Paul Saladino. We unpack the claims about plant “toxins,” the allure of ketosis, and why athletes, especially women, need carbs for performance, recovery, and hormone health. And we dig into the environmental cost of ribeye-heavy eating, why beef is one of the most resource-intensive foods on the planet, and how climate denial often gets wrapped into carnivore culture.So should you go full T-Rex? Probably not. But understanding the hype—and the risks—shows why restrictive food fads keep spreading, and why carbs are still essential for endurance athletes and long-term health.Support the ShowEternal – To check out Foundations, use the promo code YDS for 10% a one year membership.Tailwind Nutrition offers science–backed endurance fuel that actually works. Try our favorite, Blueberry Lemonade Endurance Fuel - Get 20% off your first order with code YOURDIET20Janji – Adventure-ready running gear with pockets that actually work. Use code YDS for 10% off your order.Microcosm Coaching – Human-first, athlete-centered coaching for every runner, from 5K to 100 miles and beyond.REFERENCESBurke, L. M., Ross, M. L., Garvican-Lewis, L. A., Welvaert, M., Heikura, I. A., Forbes, S. G., ... & Hawley, J. A. (2017). Low carbohydrate, high fat diet impairs exercise economy and negates the performance benefit from intensified training in elite race walkers. The Journal of Physiology, 595(9), 2785–2807. https://doi.org/10.1113/JP273230Cordain, L., Eaton, S. B., Sebastian, A., Mann, N., Lindeberg, S., Watkins, B. A., ... & Brand-Miller, J. (2005). Origins and evolution of the Western diet: Health implications for the 21st century. The American Journal of Clinical Nutrition, 81(2), 341–354. https://doi.org/10.1093/ajcn.81.2.341Hall, K. D., & Guo, J. (2017). Obesity energetics: Body weight regulation and the effects of diet composition. Gastroenterology, 152(7), 1718–1727. https://doi.org/10.1053/j.gastro.2017.01.052Jönsson, T., Granfeldt, Y., Lindeberg, S., & Hallberg, A. C. (2009). Subjective satiety and other experiences of a Paleolithic diet compared to a diabetes diet in patients with type 2 diabetes. Nutrition Journal, 8(1), 35. https://doi.org/10.1186/1475-2891-8-35Lerner, R. (1930). Adventures in diet. Harper's Monthly Magazine, 161(962), 509–518.Micha, R., Michas, G., & Mozaffarian, D. (2012). Unprocessed red and processed meats and risk of coronary artery disease and type 2 diabetes: An updated review of the evidence. Current Atherosclerosis Reports, 14(6), 515–524. https://doi.org/10.1007/s11883-012-0282-8O'Hearn, A., Tro, K., & Naiman, D. (2021). Clinical experience of medical doctors with a carnivore diet. Current Developments in Nutrition, 5(Supplement_2), 393. https://doi.org/10.1093/cdn/nzab044_067Stefansson, V. (1946). Not by bread alone. New York, NY: Macmillan.UN Food and Agriculture Organization. (2013). Tackling climate change through livestock: A global assessment of emissions and mitigation opportunities. Rome: FAO.Zhang, Y., Pan, X. F., Chen, J., Xia, L., Cao, A., Zhang, Y., ... & Pan, A. (2021). Associations of red meat, processed meat, and poultry consumption with risk of colorectal cancer: A prospective cohort study of 0.5 million Chinese adults. International Journal of Cancer, 149(5), 979–989. https://doi.org/10.1002/ijc.33694
UFC 319 was a wild night with crazy finishes and I got burnt badly. We need to rebound and we have a pretty decent fight card to preview for UFC Shanghai this week. Join us LIVE to preview this card from a gambling perspective.Guest: Dan TomTwitter (X): @DanTomMMA►Sponsor: Cloudbet https://tinyurl.com/DIEHARDMMAPromo code: DIEHARDMMA ► Spectation Sports https://spectationlink.com/DIEHARDPromo Code: DIEHARD for 20% off ► Die Hard MMA Merch: https://die-hard-mma-podcast-merch.myspreadshop.com/all0:00 Intro & UFC 319 Recap34:49 Diyar Nurgozhay vs Uran Satybaldiev46:46 Long Xiao vs Su Young You53:42 Yizha vs Westin Wilson1:01:50 Michel Pereira vs Kyle Daukaus1:09:09 Rongzhu vs Austin Hubbard1:19:08 Maheshate Hayisaer vs Gauge Young1:27:53 Taiyilake Nueraji vs Kiefer Crosbie1:35:21 Lone'er Kavanagh vs Charles Johnson1:43:19 Sumudaerji vs Kevin Borjas1:53:04 Sergei Pavlovich vs Waldo Cortes-Acosta2:02:05 Brian Ortega vs Aljamain Sterling2:12:24 Johnny Walker vs Mingyang Zhang
MMALOTN is back to give you breakdowns and predictions for UFC Shanghai: Walker vs Zhang.
In the latest edition of the MMAOB Daily Podcast, host Adam Martin and co-host Big Marcel preview UFC Shanghai: Walker vs. Zhang. Subscribe and watch the LIVE podcast on YouTube.Topics of discussion in today's MMAOB Daily Podcast episode:UFC Shanghai PreviewWho wins between Johnny Walker and Zhang Mingyang?Who wins between Aljamain Sterling and Brian Ortega?Download the audio version of the MMAOB Daily Podcast at the following links:Subscribe to the show on Apple Podcasts: https://apple.co/2BNSmSDFollow the show on Spotify: https://open.spotify.com/show/559xahM8ASjTwpz7bzUOaUSubscribe to the podcast on Google Podcasts: https://www.google.com/podcasts?feed=aHR0cHM6Ly9hbmNob3IuZm0vcy9mYTA4MGU4L3BvZGNhc3QvcnNzSubscribe to the podcast on Anchor: https://anchor.fm/adam-martin45
En un vuelo internacional en 2018, un pasajero sufrió un grave ataque cardíaco a mitad del océano. Entre los pasajeros se encontraba el Dr. Zhang Hong, cardiólogo chino, quien no tenía a mano el equipo médico habitual. Usando pajillas, cinta adhesiva y una máscara de oxígeno, improvisó un dispositivo para mantener la respiración y circulación del paciente por más de siete horas, hasta que el avión aterrizó. La situación exigía rapidez, creatividad y valentía. Zhang pudo haber esperado a que otros actuaran, pero entendió que el momento de ayudar era ese. Su acción salvó la vida del pasajero y mostró que, aun con recursos limitados, un corazón dispuesto puede hacer una diferencia eterna. En nuestra vida espiritual, muchas veces nos encontramos “en vuelo”, sin todo lo que quisiéramos para ayudar. Sin embargo, Dios nos equipa con lo esencial: Su amor, Su Espíritu y oportunidades concretas para servir. La Biblia dice en 1 Juan 3:18: “Hijitos míos, no amemos de palabra ni de lengua, sino de hecho y en verdad” (RV1960).
Agora - Governance in Web3 Agora - Governance in Web3 In this conversation, Yitong delves into the complexities of governance in the Web3 space, focusing on the Agora platform. They discuss the importance of meaningful tokens, the challenges of governance, and the innovative solutions Agora offers, including modular governance contracts and progressive decentralization. The conversation also touches on the distinction between public and private goods in governance, the role of delegation, and the future of governance in the Ethereum ecosystem. Agora helps to deploy the best end-to-end governance system without writing a single line of code.
Clean energy visionary Lei Zhang loves the Gobi Desert — the most Mars-like place on Earth. Why? Because of the promise it holds to provide the free, abundant solar and wind energy to fuel humanity's next leap forward. Sharing the story behind one of the world's largest green hydrogen projects, Zhang shows how Earth's harshest landscapes could unlock more energy reserves than the world consumes today, and encourages us all to get a little more creative in how we think about the future.For a chance to give your own TED Talk, fill out the Idea Search Application: ted.com/ideasearch.Interested in learning more about upcoming TED events? Follow these links:TEDNext: ted.com/futureyouTEDSports: ted.com/sportsTEDAI Vienna: ted.com/ai-viennaTEDAI San Francisco: ted.com/ai-sf Hosted on Acast. See acast.com/privacy for more information.
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