Podcasts about feline immunodeficiency virus

FELINE FRIDAY!   This week we have adorable, adoptable Mick Jagger from Animal Friends! This handsome guy is ready to rock out with his new family! He arrived at Animal Friends when his previous owner could no longer take care of him. He would prefer to be the only pet in the home so he can have all of the love for himself! Mick is FIV+ but that doesn't mean he can't live a normal life. FIV stands for Feline Immunodeficiency Virus, which weakens a cat's immune system, but with a proper diet, regular vet visits and staying indoors, he can live a happy and healthy life. If you're interested in learning more about Mick or the other adoptable pets at Animal Friends, please contact them directly at https://www.thinkingoutsidethecage.org/

We briefly cover several topics in this episode, are joined by silent co-host Paulie the office cat, and MOST exciting, have some outro music. When we mention Topeka Community Cat Fix (TCCF), we're talking about our local TNVR (trap/neuter/vaccinate/return) group! Check them out at tccf-tnr.org FIV is Feline Immunodeficiency Virus. Kansas was the last US state to make it legal for animal shelters to adopt out (or transfer) FIV+ cats, so it was a huge win when legislation was changed! https://www.ksnt.com/capitol-bureau/fiv-cats-can-now-be-adopted-in-kansas/ Here is more information about puppy mills from the Humane Society of the United States: https://www.humanesociety.org/all-our-fights/stopping-puppy-mills Join us next week as we dive into the path an animal takes once they are admitted into our shelter, beginning with Margaret Price, our Manager of Admissions (and so much more).

Episode 1 - Feline Immunodeficiency Virus (FIV)

The purpose of the study reported here was to compare the antiviral efficacy against feline immunodeficiency virus (FIV) and cytotoxicity in feline peripheral blood mononuclear (PBM) cells of 9 nucleoside reverse transcriptase inhibitors (NRTIs), three of which had not been evaluated against FIV in feline cells before. PBM cells were isolated from the blood of three specific pathogen-free (SPF) cats. The cytotoxic effects of the test compounds were determined by colorimetric quantification of a formazan product resulting from bioreduction of a tetrazolium reagent by viable PBM cells. Each compound was tested in 12 concentrations ranging from 0.001 to 500 M. Uninfected cells from one SPF cat were used in these assays. PBM cells (from all three SPF cats) were infected with the molecular clone FIV pPPR and the antiviral efficacy of the test compounds was assessed using a FIV p24 antigen capture enzyme-linked immunosorbent assay. Each compound was tested in 5 concentrations ranging from 0.1 to 10 M. Cytotoxic effects in feline PBM cells were observed only at concentrations over 10 M for all 9 NRTIs. Comparison of the cytotoxic effect at the highest concentration investigated (500 M) revealed that didanosine and amdoxovir were significantly less toxic than abacavir. As no cytotoxicity was noted up to a concentration of 10 M, this was set as the highest concentration for the second part of this study investigating the anti-FIV efficacy of the test compounds. All drugs induced a dose-dependent reduction of FIV replication. When compared at the highest concentration investigated, there was no significant difference in the antiviral efficacy among the test compounds. The EC50 could not be determined as none of the test compounds achieved 50% viral inhibition. The evaluated NRTIs had low cytotoxicity against feline PBM cells and appear to be safe options for further in vivo evaluation for the treatment of FIV-infected cats. There was no evidence suggesting that the newly evaluated compounds would be superior to the existing NRTIs for reducing the FIV burden of infected cats.

Fish Tank Kings Are Back The star of the highly-popular Nat Geo WILD series, Fish Tank Kings, is returning to Animal Radio® airwaves to yap about his latest project; a Coy Pond for dog trainer Cesar Millan. Summer Pests The seasons are-a-changing. With the warmer temps comes a proliferation of fleas and ticks. Now, more than ever, there is an enormous choice for over-the counter prevention and treatment. How do we choose what's best for our pets? Gordon McGee of Drs. Foster & Smith has the lowdown. Snip Snip Hero Former band leader for The John Davidson Show and top dog at Natural Balance, Joey Herrick is our "Hero Person" this week. Using his own money and time, he sends veterinarians out in a $300,000 mobile surgical vehicle to spay, neuter and vaccinate animals of poverty-level guardians. Worldwide Accreditation Program For Pet Crematory Facilities Recently Animal Radio® reported problems with pet crematoriums and keeping the remains of animals separate from each other so people get their own pet's ashes back. Now the International Association of Pet Cemeteries and Crematories has announced a worldwide Accreditation Program for Pet Crematory facilities. Breed Prejudice? A Riverside County, California Sheriff's Deputy had gone onto a property to serve an eviction notice. A pitbull, was in the yard and started barking. The deputy drew his gun, presumably to shoot the dog and shot himself in the leg instead. The deputy said that the dog had come at him aggressively and that he felt that his life was in danger. The Latest Survey On Pet Health Is Out…And It Is Not Good The Pet Health Report is compiled by Banfield Pet Hospital from its records of animals seen. The report found that one in every 300 cats is infected with Feline Immunodeficiency Virus or FIV - with the majority being male cats. Infections of Lyme Disease is also up by 21-percent. More this week Next Week: Dr. Gerald Post - Kelly Carter - Aimee Cecil

Mauro Pistello, Department of Experimental Pathology, Retrovirus Center and Virology Section, University of Pisa, Italy speaks on "What feline immunodeficiency virus can teach us about HIV". This seminar has been recorded by ICGEB Trieste

Susan Daffron talks to Amanda Casazza, the Alley Cat Allies (ACA) Atlantic City Fieldwork Coordinator about a cat named Big Daddy. This plus sized tuxedo kitty is a real "lover" who likes to snuggle up with people. He was found living along the Atlantic City Boardwalk by Alley Cat Allies volunteers, and was so friendly the group decided to put him up for adoption. For many years, ACA has had a Trap-Neuter-Return program for feral cats along the boardwalk, and also have placed adoptable cats in new loving homes. Because of his social nature Big Daddy was placed in foster care, where he is greatly enjoying indoor kitty life. Big Daddy does have a couple of medical issues that a new owner will need to understand. The first is that he has a hematoma in his ear, which needs to be cleaned a couple times a week. However, Big Daddy is incredibly good about the process and just sits in your lap while you clean his ear, so the process is easy. The second thing is that Big Daddy is FIV positive. FIV stands for Feline Immunodeficiency Virus, which is a slowly progressing virus that affects a cat's immune system. It is not transmissible to humans and can only be passed to other cats through blood transfusions or serious, penetrating bite wounds. Contrary to rumors, cats with FIV can live long, healthy lives and share their homes with other cats, as long as the cats get along and don't fight. If his new owners work with their veterinarian to keep him healthy, Big Daddy can be a loving companion for many years to come. More details on this episode MP3 Podcast - Big Daddy - A Big Love of a Cat - with Susan Daffron on PetLifeRadio.com

If you are looking a that little piece of the wild kingdom to call your own, you might consider our special cats for this episode of Cattitude. The Abyssinian and Somali breeds of cats are very reminiscent of the African Wildcat, Felis lybica and often look as if they should be sunning on the savannah rather than your window sill. The 4th most popular cat in the US, Abyssinians are known to be great problem solvers and adept at getting anywhere in the household. Later, learn about feline diseases that are still affecting our cats. We may have vaccines for Feline Leukemia and Feline Immunodeficiency Virus, but concerns, controversy and misunderstandings are keeping many people from fully comprehending the true seriousness of these diseases.

„Placebo-controlled double-blind treatment study in naturally Feline Immunodeficiency Virus-infected cats using the chemokine receptor inhibitor 1,1’-bis-1,4,8,11-tetraazacyclotetradekan (AMD3100)“ Antiretroviral efficacy of the bicyclam 1,1’-bis-1,4,8,11-tetraazacyclotetradekan (AMD3100) alone or in combination with the acyclic nucleoside phosphonate (R)-9-(2-phosphonylmethoxyethyl)adenine (PMEA) was investigated. Forty naturally FIV-infected cats were treated for a period of 6 weeks in a placebo-controlled double-blind study. Patients were randomly classified into 4 treatment groups, “Placebo”, “AMD”, “PMEA”, and “AMD/PMEA”. Placebo or the compounds AMD3100 (0,5 mg/kg body weight) and PMEA (10 mg/kg body weight) were administered subcutaneously twice a day or twice a week, respectively. Side effects of treatment with PMEA were a statistically significant decrease in the erythrocyte count, the hemoglobin concentration, the packed cell volume, and the number of neutrophil granulocytes. PMEA treatment caused a statistically significant improvement in the inflammation of the oral cavity. AMD3100 showed no clinical side effects. Serum magnesium levels decreased statistically significant with AMD treatment without causing clinical sings. Cats in the AMD group showed a statistically significant decrease of the proviral load. Therefore, AMD3100 had a clear antiviral efficacy against FIV. Side effects were not causing clinical sings and the bicyclam should be tested over a longer treatment period. Combination of both substances did not exacerbate side effects of either component. There was a decrease in proviral load in cats receiving only AMD3100 while no decrease was observed in combination with PMEA. PMEA-induced immunomodulation possibly inhibited the mechanism of action of AMD3100. T cell activation and proliferation of latently infected T cells were potentially stimulated during PMEA treatment leading to insufficient blockage of CXCR4 by AMD3100 that would prevent infection of additional cells.