Podcasts about Efficacy

In this episode of the Award-winning PRS Journal Club Podcast, 2026 Resident Ambassadors to the PRS Editorial Board – Lucas Harrison, Christopher Kalmar, and Priyanka Naidu- and special guest, Devinder Singh, MD, discuss the following articles from the June 2026 issue:   "Efficacy of Nanofat in Wound Healing: A Double-Blinded Randomized Controlled Trial" by Wongkietkachorn and Wongkietkachorn.   Read the article for FREE: https://bit.ly/Nanofat_WoundHealing   Devinder Singh, MD, is the Chief of the Division of Plastic and Reconstructive Surgery, Program Director, and a Professor of Surgery (and secondary professor of dermatology) at the University of Miami Miller School of Medicine.  READ the articles discussed in this podcast as well as free related content: https://bit.ly/JCJune26Collection   The views expressed by hosts and guests are their own and do not necessarily reflect the official policies or positions of ASPS.

Show Summary On today's episode, we're having a conversation with Army Veteran Ramon Salazar, Senior Manager of Learning and Experience Design for PsychArmor, as well as Executive Director for Warriors At Ease, an organization dedicated to empowering the military and veteran community with the tools and knowledge to harness the transformative power of yoga and meditation.Provide FeedbackAs a dedicated member of the audience, we would like to hear from you. If you PsychArmor has helped you learn, grow, and support those who've served and those who care for them, we would appreciate hearing your story. Please follow this link to share how PsychArmor has helped you in your service journey Share PsychArmor StoriesAbout Today's GuestRamón Salazar is a US Army Veteran with a diverse background in education and wellness. Holding a Master's degree in Education and experience in instructional design, he currently serves as an instructor at the University of Arizona. As an E-RYT 500 (Experienced Registered Yoga Teacher that has completed at leased 500 hours of advanced yoga teacher training and logged a minimum of 2,00 hours of teaching experience), Ramón brings a deep understanding of yoga practice, skillfully tailoring his approach to the specific needs of the military community. He incorporates trauma-informed techniques and mindful movement to foster healing and resilience. Ramón also holds various certifications in other wellness areas. His commitment to education and holistic well-being reflects his belief in yoga's power to positively impact individuals and communities.Links Mentioned in this Episode Ramon on PsychArmorWarriors At Ease websitePsychArmor Resource of the WeekThis week's resource of the week is PsychArmor's online course library, including many courses designed and led by Ramon. PsychArmor offers trusted, expert-led training for anyone who wants to better understand and support service members, Veterans, and their families. Whether you're a health care provider, educator, employer, caregiver, or simply someone who wants to make a difference — these courses are designed for you.You can find the resource here:https://learn.psycharmor.org/collections Episode Partner: Are you an organization that engages with or supports the military affiliated community? Would you like to partner with an engaged and dynamic audience of like-minded professionals? Reach out to Inquire about Partnership Opportunities Contact Us and Join Us on Social Media Email PsychArmorPsychArmor on TwitterPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families.  You can find more about the work that he is doing at www.veteranmentalhealth.com  

Kristin Fracassi, founder & CEO of Root & Splendor, and Alecia Nelson, the COO, share the origin story of a premium non-toxic laundry detergent and stain remover - developed by a mom of four who went down a rabbit hole on natural product ingredients and didn't like what she found. Kristin talks about working with formulation chemists and enzyme scientists, the moment when lab results confirmed her product matched the efficacy of big-name brands, and why full ingredient transparency is a non-negotiable for the brand. Alecia shares what it's like to join a brand she watched grow from the dream stage, and what's on the horizon with a new kitchen product line built to the same uncompromising standards. They wrap up by reflecting on how Naturally Network has opened door after door after door.Takeaways:Root & Splendor makes premium, fully non-toxic laundry detergent and stain remover formulated with 100% plant-based ingredients, scented with natural essential oils, and priced at about 33 cents per load.Kristin started the brand as a mom and homesteader, not an entrepreneur, after discovering that many "natural" products still contain harmful ingredientsRoot & Splendor is one of only a few laundry brands to achieve EWG Verified status, a third-party certification from the Environmental Working Group.Five years of R&D with formulation chemists and enzyme scientists resulted in a product that matches the efficacy of major conventional brands without any harmful ingredients.Their packaging delivers an 800% reduction in carbon footprint compared to conventional alternatives.Full ingredient transparency is a core brand commitment with every ingredient is listed on the package along with an explanation of what it does.Kristin describes conscious business as a daily choice because every day brings opportunities to cut corners.Root & Splendor is now expanding into a kitchen product line, holding to the same standards of plant-based formulation, premium efficacy, and sustainable packaging.The brand continues to grow organically through word of mouth from customers who try the product and tell their friends.Winning the Naturally San Diego Pitch Slam was a turning point for the brand, opening doors to other pitch slams, awards, and a deeply supportive network of industry peers.Sound Bites:"I was willing to sacrifice efficacy for safety, and then I did a deep dive into the ingredients and learned that a lot of natural ingredients are still not safe.""We formulate for safety and efficacy. Every ingredient is safe for people, pets, the environment, and fabrics.""I had no intention of starting a business, but once I realized we had something truly different, I wanted to bring it to everyone.""There are a million ways to cut corners as a business owner. Every day I choose to stay true to our values and our standards.""The consumer is really smart. They're educated. They know what they're looking for. The greenwashing in this space, it's pretty wild.""There's no reason to sacrifice safety or efficacy. You can have both.""This wasn't developed in a boardroom. This was developed by women, for women.""Don't ever give up on a stain."Links:Alecia Nelson LinkedIn - https://www.linkedin.com/in/alecialnelson/Kristin Fracassi LinkedIn - https://www.linkedin.com/in/kristinfracassirootandsplendor/Root & Splendor Website - https://rootandsplendor.com/Root & Splendor LinkedIn - https://www.linkedin.com/company/root-and-splendor/people/Root & Splendor on Facebook - https://www.facebook.com/rootandsplendorRoot & Splendor on Instagram - https://www.instagram.com/rootandsplendor…Naturally Network: www.naturallynetwork.org…Brands for a Better World Episode Archive - http://brandsforabetterworld.com/Brands for a Better World on LinkedIn - https://www.linkedin.com/company/brand-for-a-better-world/Modern Species - https://modernspecies.com/Modern Species on LinkedIn - https://www.linkedin.com/company/modern-species/Gage Mitchell on LinkedIn - https://www.linkedin.com/in/gagemitchell/…Print Magazine Design Podcasts - https://www.printmag.com/categories/printcast/…Heritage Radio Network - https://heritageradionetwork.org/Heritage Radio Network on LinkedIn - https://www.linkedin.com/company/heritage-radio-network/posts/Heritage Radio Network on Facebook - https://www.facebook.com/HeritageRadioNetworkHeritage Radio Network on X - https://x.com/Heritage_RadioHeritage Radio Network on Instagram - https://www.instagram.com/heritage_radio/Heritage Radio Network on Youtube - https://www.youtube.com/@heritage_radio…The Food Institute - https://foodinstitute.com/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode of the DermSurgery Digest, you'll hear in-depth summaries and expert commentary on select cosmetic and general dermatology articles featured in the June 2026 issue of Dermatologic Surgery. Featured contributors Isabela Jones, MD, and George Hruza, MD, MBA, share key insights and perspectives on the articles: Photographic Assessment of Cosmetic Outcome in Postsurgical Facial Scars Favors Rapidly Absorbable Polyglactin 910 Over Fast Absorbing Gut: A Blinded Randomized Clinical TrialRegenerative Aesthetics: Present Advances and Emerging Strategies for Optimized Tissue HealthDoes Prior Treatment With Facial Injectables Increase the Risk of Rhytidectomy Complications?Safety and Efficacy of a Multi-use Neurotoxin Protocol in Academic SettingsThis podcast is hosted by Naomi Lawrence, MD, Digital Content Editor for Dermatologic Surgery, and co-hosted by Michael Renzi, MD. Dermatologic Surgery is the official publication of the American Society for Dermatologic Surgery.The remaining cosmetic and general dermatology articles from the June issue are highlighted in a companion episode, Rapid Pearls, publishing on June 19, 2026.We welcome your feedback. Please contact communicationstaff@asds.net.

Dr. Shuvro Roy and Dr. Amanda Piquet discuss a brief overview of stiff person syndrome, as well as the trial and the trial results.  Read more about this abstract on the AAN website.   Show transcript:  Dr. Shuvro Roy: Hi, this is Shuvro Roy from the University of Washington and welcome to today's Neurology Minute. I just wrapped a longer conversation with Amanda Piquet from the University of Colorado Anschutz School of Medicine. We were just talking about the recent Phase 2 trial evaluating Miv-cel Kyverna Therapeutics' anti-CD19 CAR T-cell therapy in patients with Stiff Person Syndrome. Amanda, would you mind taking us through a brief overview of SPS as well as the trial and their trial results? Dr. Amanda Piquet: So Stiff Person Syndrome, or SPS, is a rare disabling autoimmune neurologic disease with a major unmet need. About 80% of patients ultimately lose their mobility and we currently have no FDA approved therapies. Existing treatments like IVIG, rituximab, and plasmapheresis are all used off label, often requiring chronic dosing and frequently failing to stop progression. KYSA-8 is a registrational Phase 2 study of 26 patients with refractory SPS. Patients experienced rapid, statistically significant and clinically meaningful improvement across all primary and secondary endpoints. Primary endpoint was the timed 25-foot walk. And this improved by a median of 46% at 16 weeks. Of patients requiring walking aids at baseline, about two thirds no longer needed them by week 16 to complete that 25-foot walk. Some patients who had struggled to walk were even able to run again after treatment. Another key finding was that all patients discontinued chronic immune therapies and remained off treatment as of the last follow-up. From a safety standpoint, miv-cel was generally well tolerated, with no high grade CRS or ICANS observed. In my opinion, these outcomes are unlike anything we've seen previously with Stiff Person Syndrome and may represent a paradigm shift, not only for SPS, but potentially for other antibody-mediated neurologic diseases more broadly. Dr. Shuvro Roy: Just curious, are there any upcoming implications for the application of this treatment for patients, you think, in the coming year or so? Dr. Amanda Piquet: Kyverna, the company who developed miv-cel, has initiated a rolling BLA with the FDA for potential approval and this would be, if approved, the first CAR-T therapy for SPS. So we're anxiously awaiting the outcome of that process. Dr. Shuvro Roy: Fantastic. Amanda, thank you so much for your time. And if you are intrigued and want to know more details behind the findings in the study as well as a conversation around CAR-T therapy for autoimmune neurologic disease as a whole, I encourage you to check out the Neurology Podcast feed for our full conversation there. Thanks for tuning in.  

Dr. Shuvro Roy and Dr. Amanda Piquet discuss a brief overview of stiff person syndrome, as well as the trial and the trial results.  Read more about this abstract on the AAN website.   Show transcript:  Dr. Shuvro Roy: Hi, this is Shuvro Roy from the University of Washington and welcome to today's Neurology Minute. I just wrapped a longer conversation with Amanda Piquet from the University of Colorado Anschutz School of Medicine. We were just talking about the recent Phase 2 trial evaluating Miv-cel Kyverna Therapeutics' anti-CD19 CAR T-cell therapy in patients with Stiff Person Syndrome. Amanda, would you mind taking us through a brief overview of SPS as well as the trial and their trial results? Dr. Amanda Piquet: So Stiff Person Syndrome, or SPS, is a rare disabling autoimmune neurologic disease with a major unmet need. About 80% of patients ultimately lose their mobility and we currently have no FDA approved therapies. Existing treatments like IVIG, rituximab, and plasmapheresis are all used off label, often requiring chronic dosing and frequently failing to stop progression. KYSA-8 is a registrational Phase 2 study of 26 patients with refractory SPS. Patients experienced rapid, statistically significant and clinically meaningful improvement across all primary and secondary endpoints. Primary endpoint was the timed 25-foot walk. And this improved by a median of 46% at 16 weeks. Of patients requiring walking aids at baseline, about two thirds no longer needed them by week 16 to complete that 25-foot walk. Some patients who had struggled to walk were even able to run again after treatment. Another key finding was that all patients discontinued chronic immune therapies and remained off treatment as of the last follow-up. From a safety standpoint, miv-cel was generally well tolerated, with no high grade CRS or ICANS observed. In my opinion, these outcomes are unlike anything we've seen previously with Stiff Person Syndrome and may represent a paradigm shift, not only for SPS, but potentially for other antibody-mediated neurologic diseases more broadly. Dr. Shuvro Roy: Just curious, are there any upcoming implications for the application of this treatment for patients, you think, in the coming year or so? Dr. Amanda Piquet: Kyverna, the company who developed miv-cel, has initiated a rolling BLA with the FDA for potential approval and this would be, if approved, the first CAR-T therapy for SPS. So we're anxiously awaiting the outcome of that process. Dr. Shuvro Roy: Fantastic. Amanda, thank you so much for your time. And if you are intrigued and want to know more details behind the findings in the study as well as a conversation around CAR-T therapy for autoimmune neurologic disease as a whole, I encourage you to check out the Neurology Podcast feed for our full conversation there. Thanks for tuning in.  

For more information regarding this CME/CE activity and to complete the CME/CE requirements and claim credit for this activity, visit:https://www.mycme.com/courses/the-evolving-role-of-antibody-drug-conjugates-in-metastatic-triple-negative-breast-cancer-10800SummaryThis CME/CE-certified podcast will provide multidisciplinary clinicians with an evidence-based update on the evolving role of TROP2-directed antibody-drug conjugates (ADCs) in the frontline treatment of metastatic triple-negative breast cancer. A medical and an ocular oncology specialist review the latest efficacy and safety data from pivotal clinical trials evaluating ADCs, their integration into contemporary treatment algorithms, and guideline recommendations based on PD-L1 status, BRCA mutation status, and immunotherapy eligibility. Learners will explore key factors influencing treatment selection, compare the benefits and limitations of more established therapeutic options, and examine practical strategies for preventing, recognizing, and managing ADC-associated toxicities. Special emphasis will be placed on multidisciplinary approaches to the management of ocular adverse events and other clinically significant toxicities to optimize patient outcomes and support safe implementation of these therapies in clinical practice.Learning ObjectivesEvaluate the current and emerging clinical evidence surrounding the use of trophoblast cell-surface antigen 2 (TROP2)-directed antibody-drug conjugates (ADCs) in the first-line treatment of metastatic triple-negative breast cancer (TNBC)Integrate TROP2-directed ADCs into frontline treatment regimens for metastatic TNBC based on the latest clinical evidence, guidelines, and patient- and tumor-specific factorsApply multidisciplinary and patient-centric strategies for the prevention, recognition, and management of toxicities associated with the use of TROP2-directed ADCs in patients with metastatic TNBCThis activity is accredited for CME/CE CreditThe National Association for Continuing Education is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.The National Association for Continuing Education designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.The National Association for Continuing Education is accredited by the American Association of Nurse Practitioners as an approved provider of nurse practitioner continuing education. Provider number: 121222. This activity is approved for 0.50 contact hours (which includes 0.50 hours of pharmacology). For additional information about the accreditation of this program, please contact NACE at info@naceonline.com.Faculty and Moderator Aditya Bardia, MDProgram Director, Breast Medical Oncology, UCLAProfessor of Medicine, UCLALos Angeles, CADr. Bardia has disclosed the following financial relationships:Consultant: Alyssum, AstraZeneca/Daiichi, BMS, Eli Lilly, Genentech, Gilead, Menarini, Merck, Novartis, Pfizer, VyomeAdvisor/Advisory Board: Alyssum, AstraZeneca/Daiichi, Eli Lilly, Genentech, Gilead, Menarini, Merck, Novartis, Pfizer, VyomeContracted Research: AstraZeneca/Daiichi, Eli Lilly, Genentech, Gilead, Menarini, Merck, Novartis, PfizerStock options: Vyome (immuno-inflammatory and rare diseases)All of his consultant, advisor/advisory board, and contracted research disclosures are related to cancer.Maura Di Nicola, MDAssistant Professor of OphthalmologyBascom Palmer Eye InstituteMedical Director of Imaging and EchographyBascom Palmer Eye InstituteMiami, FLDr. Di Nicola has disclosed the following financial relationships:Consultant: AbbVie (ophthalmology), SpringWorks Therapeutics (oncology)Advisor/Advisory Board: AbbVie (ophthalmology)Research Grant: Castle Biosciences (ocular oncology)Please review additional planner disclosures here.Disclosure of Commercial SupportThis educational activity is supported by a medical education grant from AstraZeneca Pharmaceuticals and a medical education grant from Daiichi Sankyo, Inc.Please visit  http://naceonline.com to engage in more live and on demand CME/CE content.

Show Summary On today's episode, we're having a conversation with Licensed Clinical Social Worker Amanda Noyes, the founder of Finding Freedom Therapy and member of the DFW First Responders Support Network. We talk about Trauma therapy and mental health networks for service members, veterans and first responders Provide FeedbackAs a dedicated member of the audience, we would like to hear from you. If you PsychArmor has helped you learn, grow, and support those who've served and those who care for them, we would appreciate hearing your story. Please follow this link to share how PsychArmor has helped you in your service journey Share PsychArmor StoriesAbout Today's GuestAmanda Noyes is the founder of Finding Freedom Therapy. As a Licensed Clinical Social Worker–Supervisor with over 25 years of experience, she has had the opportunity to work in numerous crisis situations where she witnessed firsthand the gravity of trauma and grief. It was in these situations that she realized there were not enough opportunities to heal from trauma and loss after the initial crisis. With this knowledge, she formed Finding Freedom Therapy, PLLC, in 2014 with the vision of providing specialized treatment to those who have endured (or are continuing to endure) horrific traumas and unspeakable losses.After earning her degree in psychology and international studies from Texas A&M University, Amanda pursued her Master of Science in Social Work at the University of Texas at Austin. Throughout her career, she has had the unique opportunity to gain notable hands-on experience, much of which was working in conjunction with the military, first responders, and frontline workers. She has worked alongside probation and parole officers in the field, with police officers on-scene, supported doctors and nurses in the ED and ICU departments of level-one trauma centers, counseled families of the recently deceased at the moment of loss, and worked next to the U.S. National Guard when assisting during Hurricanes Katrina, Rita, Ike, and Harvey.Amanda's experience with veterans and military service members began early in her career with her graduate internship at the Michael E. DeBakey VA Hospital, and later continued with her work as lead trauma therapist for an inpatient military program, Freedom Care, where she worked with active-duty combat military and veterans suffering from PTSD. She is trained in Cognitive Processing Therapy (CPT), Accelerated Resolution Therapy (ART), and Written Exposure Therapy (WET). Each and every step of her career has shaped and strengthened her ability to better assist clients through the most difficult times in their lives.Links Mentioned in this Episode Finding Freedom Therapy WebsiteDFW First Responders Support NetworkPsychArmor Resource of the WeekThis week's resource of the week is the PsychArmor course Trauma Informed Interactions with Veterans. This course defines trauma and how it presents itself and is specifically designed to help volunteers interact with Veterans dealing with trauma that affects their health and/or ability to function.You can find the resource here: https://learn.psycharmor.org/courses/trauma-informed-interactions-with-veterans Episode Partner: Are you an organization that engages with or supports the military affiliated community? Would you like to partner with an engaged and dynamic audience of like-minded professionals? Reach out to Inquire about Partnership Opportunities Contact Us and Join Us on Social Media Email PsychArmorPsychArmor on TwitterPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families.  You can find more about the work that he is doing at www.veteranmentalhealth.com  

Outline and Show NotesUrgency and Efficacy with Taylor CrosbySponsor Spot 1:I'd like to thank Kaleidoscope Adventures for sponsoring today's show. Lots of companies can help you organize class trips, but Kaleidoscope helps you organize adventures – because isn't that what student trips should be? Kaleidscope is a full-service tour company offering a range of adventure opportunities and they excel at customizing trips based on your unique context, needs, and goals. Kaleidoscope offers exceptional travel experiences for students (and their group leaders). Thinking about student travel? Reach out to Kaleidoscope using the link in the show notes.Show IntroGuest Bio:A true product of Greenwood, South Carolina,Taylor Crosby has dedicated her career to the community that raised her. A graduate of Greenwood High School (Class of 2006), she went on to build an academic foundation at Lander University, earning a Bachelor's in Early Childhood Education (2010) and a Master's in Lower Elementary Montessori (2013).Driven by a commitment to educational excellence, she reached a career milestone in 2018 by earning her Educational Specialist degree from Clemson University. Today, she combines her deep local roots with leadership expertise to impact the next generation of learners. Outside of being Principal at Pinecrest, she is embracing life in Hodges, SC. Whether she's out on the land with her husband of 14 years, Tripp riding the Polaris Ranger with their two boys, Clayton and Nickles, or cheering at a local ballgame, she finds her greatest joy in the simple traditions of South Carolina living.  Warmup questions:We always like to start with a celebration. What are you celebrating today?Is there a story that will help listeners understand why you are doing what you do?Questions/Topics/PromptsDescribing what I see from the outside: Urgency, relentless focus on teaching and learning, clear and honest conversations, high expectations, no excuses. What am I missing?Share how you create a sense of urgency…Every administrator wants to “get into classrooms” but few achieve it to the degree you do. What are you doing differently that lets you get into classrooms?I know there is a directness in your conversations that many leaders, myself included, are hesitant to embrace. How do you manage other people's emotions when having very candid conversations? Sponsor Spot 2:I want to thank IXL for sponsoring this podcast…Everyone talks about the power of data-driven instruction. But what does that actually look like? Look no further than IXL, the ultimate online learning and teaching platform for K to 12. IXL gives you meaningful insights that drive real progress, and research can prove it. Studies across 45 states show that schools who use IXL outperform other schools on state tests. Educators who use IXL love that they can easily see how their school is performing in real-time to make better instructional decisions. And IXL doesn't stop at just data. IXL also brings an entire ecosystem of resources for your teachers, with a complete curriculum, personalized learning plans, and so much more. It's no wonder that IXL is used in 95 of the top 100 school districts. Ready to join them? Visit ixl.com/assistant to get started.Closing questions:What part of your own leadership are you still trying to get better at?If listeners could take just one thing away from today's podcast, what would it be?Before we go, is there anything else that you'd like to share with our listeners?Where can people learn more about you and your work…Summary/wrap upSpecial thanks to the amazing Ranford Almond for the great music on the show. Please support Ranford and the show by checking out his music!Ranford's homepage: https://ranfordalmond.comRanford's music on streaming services: https://streamlink.to/ranfordalmond-oldsoulInstagram: https://www.instagram.com/ranfordalmond/Facebook: https://www.facebook.com/ranfordalmond/Sponsor Links:IXL: http://ixl.com/assistant Kaleidoscope Adventures: https://www.kaleidoscopeadventures.com/the-assistant-principal-podcast-kaleidoscope-adventures/CloseLeadership is a journey and thank you for choosing to walk some of this magical path with me.You can find links to all sorts of stuff in the show notes, including my website https://www.frederickbuskey.com/I love hearing from you. If you have comments or questions, or are interested in having me speak at your school or conference, email me at frederick@frederickbuskey.com or connect with me on LinkedIn.If you are tired of spending time putting out fires and would rather invest time supporting and growing teachers, consider reading my book, A School Leader's Guide to Reclaiming Purpose. The book is available on Amazon. You can find links to it, as well as free book study materials on my website at https://www.frederickbuskey.com/reclaiming-purpose.html Please remember to subscribe, rate, and review the podcast.Remember the secret to good leadership:Be intentional in choosing how you will show up for othersBe fully presentAsk reflective questionsAnd then just listenDon't overcomplicate it, the value is in the listening.Have a great rest of the week!Cheers!Guest Links:Frederick's Links:Email: frederick@frederickbuskey.comWebsite: https://www.frederickbuskey.com/ LinkedIn: http://www.linkedin.com/in/strategicleadershipconsulting Daily Email subscribe: https://adept-experimenter-3588.ck.page/fdf37cbf3a The Strategic Leader's Guide to Reclaiming Purpose: https://www.amazon.com/dp/B0CWRS2F6N?ref_=pe_93986420_774957520

Dr. Shuvro Roy talks with Dr. Amanda L. Piquet about the efficacy and safety of miv-cel in patients with stiff person syndrome.  Read more about this abstract on the AAN website.   Disclosures can be found at Neurology.org. 

All of this week's episodes of It Could Happen Here put together in one large file. - Bears! And the Guys Who Don’t Like Them - How to Potluck Your Way to a Union - What’s In the DNC’s 2024 Autopsy - The War on Iran and Convergences of Fascism - Executive Disorder: California Elections, SCOTUS Approves GOP Map, Greg Bovino Update You can now listen to all Cool Zone Media shows, 100% ad-free through the Cooler Zone Media subscription, available exclusively on Apple Podcasts. So, open your Apple Podcasts app, search for “Cooler Zone Media” and subscribe today! http://apple.co/coolerzone Sources/Links: Bears! And the Guys Who Don’t Like Them https://www.nps.gov/glac/learn/news/missing-hiker-and-bear-encounter-victim-identified.htm https://www.hcn.org/issues/49-9/zinke-went-to-bears-ears-to-listen-but-supporters-felt-unheard/ https://x.com/RepRyanZinke/status/2054303113549381650?s=20 https://cdn.ca9.uscourts.gov/datastore/opinions/2017/10/25/16-30033.pdf https://www.biologicaldiversity.org/campaigns/Endangered-Species-Act-at-50/ https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5829a2.htm https://coloradosun.com/2024/04/16/dying-wolf-struck-by-snowmobile-shown-off-in-wyoming-bar/ https://www.researchgate.net/publication/261982557_Efficacy_of_Firearms_for_Bear_Deterrence_in_Alaska https://www.bearwise.org/wp-content/uploads/2017/07/efficacy-of-bear-spray-smith-et-al.-2010.pdf https://alaskapublic.org/news/environment/2026-05-07/after-legal-challenge-alaska-judge-approves-states-revised-bear-cull-in-southwest-alaska https://www.documentcloud.org/documents/28097859-250506-mulchatna/ https://www.akleg.gov/basis/Bill/Text/34?Hsid=HB0364A https://propakistani.pk/2026/05/28/mma-fighter-killed-in-bear-attack-in-canada/ How to Potluck Your Way to a Union https://www.gofundme.com/f/MujiWorkersUnited https://www.instagram.com/mujiworkersunited.pdx/ What’s In the DNC’s 2024 Autopsy https://democrats.org/wp-content/uploads/2026/05/May-20-2026.pdf https://www.politico.com/news/2025/02/01/ken-martin-elected-dnc-party-chair-00201938 https://www.cnn.com/2026/05/21/politics/dnc-autopsy-inside-story https://www.thebulwark.com/p/heres-what-i-told-the-dnc-autopsy-biden-harris-2024-lessons-democrats-2028 https://www.cnn.com/2026/05/21/politics/dnc-autopsy-takeaways-vis The War on Iran and Convergences of Fascism Mohammad Ali Kadivar on the Iranian regime’s popular mobilization - https://www.journalofdemocracy.org/online-exclusive/why-the-iranian-regime-owns-the-streets/ Moustafa Bayoumi on the anti-Palestinian roots of Islamophobia - https://www.theguardian.com/news/article/2024/may/23/islamophobia-us-palestine-history Negar Razavi’s website - https://negarsrazavi.com/ Executive Disorder: California Elections, SCOTUS Approves GOP Map, Greg Bovino Update https://x.com/atrupar/status/2061537793843532054?s=20 https://x.com/Tomhennessey69/status/2061343239794299374 https://remigrationsummit.com/ https://www.politico.eu/article/afd-vox-mingle-with-ex-us-border-patrol-chief-white-nationalist-leader-at-remigration-summit/ https://www.breizh-info.com/2026/05/28/260619/gregory-bovino-lhomme-qui-a-pilote-les-operations-trump-contre-limmigration-illegale-parle-a-leurope-interview/ https://x.com/Osinttechnical/status/2061550046571528666?s=20 https://x.com/CENTCOM/status/2061419519705223257?s=20 https://www.axios.com/2026/06/01/trump-netanyahu-israel-lebanon-call https://www.nbcnews.com/politics/national-security/iran-may-used-chinese-missile-shoot-us-fighter-jet-sources-say-rcna347555 https://www.patreon.com/posts/dont-confuse-and-159583359 https://bsky.app/profile/atrupar.com/post/3mndeoj7qnk24 https://public-inspection.federalregister.gov/2026-11094.pdf https://www.whitehouse.gov/presidential-actions/2026/06/promoting-advanced-artificial-intelligence-innovation-and-security/ https://thehill.com/homenews/administration/5905542-donald-trump-bill-pulte-odni-democratic-reaction/ https://www.supremecourt.gov/opinions/25pdf/25a1314_7m58.pdf https://www.scotusblog.com/2026/06/supreme-court-permits-alabama-to-use-congressional-map-struck-by-lower-court-as-racially-discrim/ https://www.npr.org/2026/06/03/nx-s1-5844678/trump-science-funding-omb-budget-office-rule-change https://www.science.org/doi/10.1126/science.aej3572 https://www.science.org/doi/10.1126/science.adz9553 https://elizabethginexi.substack.com/p/this-new-omb-rule-is-bigger-than https://elizabethginexi.substack.com/p/summary-of-key-changes-in-ombs-proposed https://www.federalregister.gov/documents/2026/05/29/2026-10817/regulation-for-federal-financial-assistance https://www.science.org/content/article/researchers-slam-hhs-report-gender-affirming-care-youth https://www.insidehighered.com/news/government/science-research-policy/2026/05/29/omb-proposes-rules-establishing-politicalSee omnystudio.com/listener for privacy information.

Un nouvel épisode du Pharmascope est disponible! Dans ce 178e épisode, Nicolas, Olivier et Amélie tentent de pondre des réponses un tant soi peu intelligentes à vos excellentes questions. Nous discutons d'ajustement de lévothyroxine, du suivi des IECA/ARA, du rôle de la cariprazine et de l'impact des inhibiteurs du SGLT-2 sur le magnésium.   Les objectifs pour cet épisode sont les suivants: Discuter des modalités d'ajustement de la lévothyroxine et de la déprescription potentielle de celle-ci Discuter des suivis de laboratoire suivant l'initiation d'un ARA ou d'un IECA Discuter des évidences portant sur l'utilisation de la cariprazine Discuter de l'impact des  inhibiteurs du SGLT-2 sur le magnésium Ressources pertinentes en lien avec l'épisode Jonklaas J, et coll; American Thyroid Association Task Force on Thyroid Hormone Replacement. Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement. Thyroid. 2014 Dec;24(12):1670-751. Van Uytfanghe K, et coll. Thyroid Stimulating Hormone and Thyroid Hormones (Triiodothyronine and Thyroxine): An American Thyroid Association-Commissioned Review of Current Clinical and Laboratory Status. Thyroid. 2023 Sep;33(9):1013-1028. Ravensberg J, et coll. Discontinuation of Levothyroxine in Adults Aged 60 Years or Older. JAMA. 2026 Apr 6;335(17):1491–8. RPE de néphrologie de l'APES. Place des IECA et des ARA dans le traitement de la maladie rénale chronique. Septembre 2025. Bhandari S, et coll; STOP ACEi Trial Investigators. Renin-Angiotensin System Inhibition in Advanced Chronic Kidney Disease. N Engl J Med. 2022 Dec 1;387(22):2021-2032. Clase CM, et coll. Acute change in glomerular filtration rate with inhibition of the renin-angiotensin system does not predict subsequent renal and cardiovascular outcomes. Kidney Int 2017;91:683-90. Garlo KG, et coll. Association of changes in creatinine and potassium levels after initiation of renin angiotensin aldosterone system inhibitors with emergency department visits, hospitalizations, and mortality in individuals with chronic kidney disease. JAMA Netw Open 2018;1:e183874. Monographie de produit, Abbvie. VRAYLAR (cariprazine). Canada, 6 mars 2024. Barabassy A, et coll. Transdiagnostic Efficacy of Cariprazine: A Systematic Review and Meta-Analysis of Efficacy Across Ten Symptom Domains. Pharmaceuticals (Basel). 2025 Jul 2;18(7):995. Németh G, et coll. Cariprazine versus risperidone monotherapy for treatment of predominant negative symptoms in patients with schizophrenia: a randomised, double-blind, controlled trial. Lancet. 2017 Mar 18;389(10074):1103-1113. Fava M, et coll. Efficacy of adjunctive low-dose cariprazine in major depressive disorder: a randomized, double-blind, placebo-controlled trial. Int Clin Psychopharmacol. 2018 Nov;33(6):312-321. Durgam S, et coll. Efficacy and safety of adjunctive cariprazine in inadequate responders to antidepressants: a randomized, double-blind, placebo-controlled study in adult patients with major depressive disorder. J Clin Psychiatry. 2016 Mar;77(3):371-8. Barabassy A, Csehi R, Dombi ZB, Szatmári B, Brevig T, Németh G. Transdiagnostic Efficacy of Cariprazine: A Systematic Review and Meta-Analysis of Efficacy Across Ten Symptom Domains. Pharmaceuticals (Basel). 2025 Jul 2;18(7):995. Zhang J, et coll. Comparative Effects of Sodium-Glucose Cotransporter 2 Inhibitors on Serum Electrolyte Levels in Patients with Type 2 Diabetes: A Pairwise and Network Meta-Analysis of Randomized Controlled Trials. Kidney360. 2022 Jan 19;3(3):477-487. Toto RD, et coll. Correction of hypomagnesemia by dapagliflozin in patients with type 2 diabetes: A post hoc analysis of 10 randomized, placebo-controlled trials. J Diabetes Complications. 2019 Oct;33(10):107402.

Can a simple blood test predict Alzheimer's before symptoms start? Is pink noise the secret to a better night's sleep? Join Tanner, Dr. Miles, and Jade (Mortal Kombat warrior?) for another breakdown of the latest headlines in medicine and health science. In this episode, we're diving into three fascinating updates you can actually use to improve your daily life: A Major Leap in Alzheimer's Screening: We discuss a new, highly accessible, and affordable blood test that is changing the game for early detection. The Color of Sound: You've definitely heard of white noise, but we look at why pink noise might be the superior option for deeper, more restorative sleep. Or maybe it's not! Beyond Antibiotics: We all know how antibiotics disrupt the gut microbiome, but new research shows that common medications (including popular diabetes and high blood pressure drugs) can also dramatically alter your gut health for better or worse. At HFWDM, we do the heavy lifting in the deep waters of medical research so you don't have to. Our goal is to bring you cutting edge and peer-reviewed science in a way that is easy to understand, practical, and entertaining. Have a question or a topic you want us to cover? We want to hear from you! Drop us a line at questions@healthfilesradio.com. Just a few of the resources used with this episode: Efficacy of pink noise and earplugs for mitigating the effects of intermittent environmental noise exposure on sleep https://academic.oup.com/sleep/advance-article/doi/10.1093/sleep/zsag001/8452884?searchresult=1&login=false Drugs Can Reshape Your Patient's Gut — Sometimes for Years A hidden confounder for microbiome studies: medications used years before sample collection https://pubmed.ncbi.nlm.nih.gov/40910778/#article-details Impact of Early Alzheimer's Diagnosis on Treatment of Cognitive Decline. Dr Paul Rosenberg, of the Johns Hopkins University School of Medicine video interview.

Welcome back! Today, we are looking at Modafinil and it's nuanced use in psychiatry.References:Provigil (modafinil) [prescribing information]. North Wales, PA: Teva Pharmaceuticals USA, Inc. U.S. Food and Drug Administration. Available at: https://www.accessdata.fda.gov/drugsatfdadocs/label/2015/020717s037s038lbl.pdfSchwartz JR. Modafinil in the treatment of excessive sleepiness. Drug Des Devel Ther. 2009;2:71–85.Kaplan S, Goehring EL Jr, Engel T, et al. Cardiovascular outcomes associated with modafinil in patients with obstructive sleep apnea. Pharmacoepidemiol Drug Saf. 2018;27(11):1182–1190. doi:10.1002/pds.4642Cortese S, Adamo N, Del Giovane C, et al. Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis. Lancet Psychiatry. 2018;5(9):727–738. doi:10.1016/S2215-0366(18)30269-4Goss AJ, Kaser M, Costafreda SG, Sahakian BJ, Fu CH. Modafinil augmentation therapy in unipolar and bipolar depression: a systematic review and meta-analysis of randomized controlled trials. J Clin Psychiatry. 2013;74(11):1101–1107. doi:10.4088/JCP.13r08560Bahji A, Mesbah-Oskui L. Comparative efficacy and safety of stimulant-type medications for depression: a systematic review and network meta-analysis. J Affect Disord. 2021;292:416–423. doi:10.1016/j.jad.2021.05.119Nunez NA, Singh B, Jorgensen A, et al. Efficacy and tolerability of adjunctive modafinil/armodafinil in bipolar depression: a meta-analysis of randomized controlled trials. Bipolar Disord. 2020;22(2):109–120. doi:10.1111/bdi.12859

Show Summary On today's episode, we're having a conversation with Marine Veteran Luke Urick, the Executive Director of the Montana Vet Program, an organization that takes Veterans into the Montana wilderness to rediscover strength, purpose, and camaraderie through therapeutic adventure and conservation. Provide FeedbackAs a dedicated member of the audience, we would like to hear from you. If you PsychArmor has helped you learn, grow, and support those who've served and those who care for them, we would appreciate hearing your story. Please follow this link to share how PsychArmor has helped you in your service journey Share PsychArmor StoriesAbout Today's GuestLUKE URICKLuke Urick is a U.S. Marine Corps Veteran and the Founder and Executive Director of the Montana Vet Program, where he has led transformative outdoor-based experiences for Veterans for the past nine years. Serving from 2003 to 2012 as a Scout Sniper, Mountain Leader, and Survival Instructor, Luke deployed in support of combat operations and earned numerous honors, including the Navy Commendation Medal with “V” for valor and the Purple Heart. His military service shaped a lifelong commitment to resilience, leadership, and helping others navigate adversity.After transitioning from the military, Luke earned a Bachelor of Arts in Psychology and a Master of Science in Organizational Management, combining his understanding of human behavior with strong leadership expertise. Through the Montana Vet Program, he guides Veterans into the wilderness to rediscover purpose, strength, and camaraderie through shared challenge and therapeutic adventure. His work reflects a deep belief in the healing power of connection, nature, and service.Links Mentioned in this Episode Montana Vet Program WebsiteMVP TripsPsychArmor Resource of the WeekThis week's resource of the week is the PsychArmor course Slowing Down and One Pointed Attention. In this course, Dr. Jill Borman discusses the tools that make mantram repetition more effective and useful: slowing down and one-pointed attention.You can find the resource here: https://learn.psycharmor.org/courses/slowing-down-and-one-pointed-attention Episode Partner: Are you an organization that engages with or supports the military affiliated community? Would you like to partner with an engaged and dynamic audience of like-minded professionals? Reach out to Inquire about Partnership Opportunities Contact Us and Join Us on Social Media Email PsychArmorPsychArmor on TwitterPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families.  You can find more about the work that he is doing at www.veteranmentalhealth.com  

Shota Yamamoto, MD, PhD; Takayuki Niitsu, MD; and Kenneth N. Olivier, MD, MPH, join CHEST® Journal Podcast Moderator Gretchen Winter, MD, to discuss their research into the current efficacy and safety profile of antiinflammatory therapies for bronchiectasis.   DOI: 10.1016/j.chest.2025.12.035 Disclaimer: The purpose of this activity is to expand the reach of CHEST content through awareness, critique, and discussion. All articles have undergone peer review for methodologic rigor and audience relevance. Any views asserted are those of the speakers and are not endorsed by CHEST. Listeners should be aware that speakers' opinions may vary and are advised to read the full corresponding journal article(s) for complete context. This content should not be used as a basis for medical advice or treatment, nor should it substitute the judgment used by clinicians in the practice of evidence-based medicine.  

In this episode of The Wrap, Chris Whalen reveals bank incomes are up but the real story is the trading side of the house driving earnings, not lending, as deposits grow faster than assets forcing banks into trading operations. He warns private credit default rates have hit a record 6%, nearly 10 times worse than bank default rates, signaling the end of the credit cycle as non-banks now lead lending. Whalen predicts double-digit inflation remains likely, expects QE5 to come despite Warsh's denials since the Fed balance sheet must grow proportionally with federal debt, and argues Fed policy is losing efficacy against external war-driven inflation that raising rates won't fix. He discusses massive housing consolidation and M&A deals coming as mortgage lenders face crushing higher rates, details how private equity is rolling up every service provider imaginable (plumbers, electricians, dentists, oncologists) and "screwing them up terribly," warns TIPS aren't reflecting true inflation, and predicts major housing lender mergers between now and year end. Whalen maintains his thesis that the Fed doesn't control long-term rates and that shrinking the balance sheet would be more effective than raising the Fed funds rate, argues the AI momentum trade is crowded and silly, and expects no action from the Fed in June but potential rate hike language removal from statements. Thank you to our partners at Goldco. Get your free 2026 Gold & Silver Kit at https://goldco.com/thewrap or call 855-573-0817Links:    The Institutional Risk Analyst: https://www.theinstitutionalriskanalyst.com/  The Wrap: https://www.theinstitutionalriskanalyst.com/post/theira847Inflated book (2nd edition): https://www.barnesandnoble.com/w/inflated-r-christopher-whalen/1146303673Twitter/X: https://twitter.com/rcwhalen    Use the code TheWrap2026 for 25% off your first year of The Institutional Risk Analyst https://www.theinstitutionalriskanalyst.com/plans-pricingTimestamps:0:00 Introduction - Bank Income Up, Stocks Sideways01:00 Banks recap5:06 Private credit default rate record 6% - 10x worse than banks6:14 Who's most exposed to private credit losses?7:36 Reversal in low rate environment impact9:39 Kevin Warsh and Fed balance sheet strategy10:01 Double-digit inflation still likely?10:40 What were worst impacts of QE?11:00 Housing was the headline impact of QE12:43 Fed housing subsidy went outside their mandate12:51 Fed is progressive institution out of control13:49 We may be closer to QE5 than Bessent knows15:05 Fed balance sheet must grow with federal debt16:04 New leadership - what about Fed funds rate?16:18 Potential for cut or hike?18:06 Base case still stagflation?20:12 Private equity excess cash looking for yield22:10 Politics of housing affordability daunting23:35 Viewer questions - TIPS24:26 Municipal bond default risk 26:24 Why higher inflation won't drive down gold28:42 AI craziness - momentum market29:31 Trump wanted cuts but prospects disappearing29:54 June FOMC - don't expect action31:20 Fed balance sheet more important than Fed funds rate33:11 Next week - bank report Monday

Moderator​: Lucas Marchand, MD, BSFaculty: Zachary Working, MD, Patrick Kellam, MD, Graham DeKeyser, MDArticle #1: Type III Open Tibia Fractures: Immediate Antibiotic All-FacultyProphylaxis Minimizes Infection Article #2: Allgöwer-Donati Versus Vertical Mattress Suture All-FacultyTechnique Impact on Perfusion in Ankle FractureSurgery: A Randomized Clinical Trial Using Intraoperative AngiographyArticle #3: Efficacy of Topical Antibiotic Powder Application in the All-FacultyEmergency Department on Reducing Deep Fracture-RelatedInfection in Type III Open Lower Extremity Fractures: A Multicenter StudyArticle #4: Infection and Nonunion Rates in Open Fractures: Description All-Facultyof 6,042 Fractures from the FLOW and PREP-IT Trials ​​

In this week's episode, Blood editor Dr. James Griffin interviews Drs. Johnny Mahlangu and Joseph Rocco on their articles published in volume 147 issue 9 of Blood.  Dr. Mahlangu discusses study details and next steps from "Efficacy and safety of marstacimab prophylaxis in hemophilia A/B with inhibitors: results from the phase 3 BASIS trial" which shows that bleeding was reduced by 93% with subcutaneous marstacimab. Dr. Rocco shares the development behind "CXCL9 as a novel prognostic marker to identify high-risk adults with hemophagocytic lymphohistiocytosis", and the insights gained from measuring a new surrogate marker of IFN-γ activity predicting severity and mortality.

In this episode, Dr. Steve Gard, Editor-in-Chief of the Journal of Prosthetics and Orthotics, speaks with Amandi Rhett, MS, CPO, LPO, FAAOP, assistant professor in the Baylor College of Medicine Orthotics and Prosthetics Program and assistant dean of community health at the college's School of Health Professions, about the impact of microaggressions in healthcare and efforts to address them within the orthotics and prosthetics profession. Rhett explains how subtle verbal, nonverbal, and environmental slights directed toward marginalized groups can affect workplace culture, clinician-patient relationships, and patient outcomes. Drawing from her own experiences and recognizing a lack of O&P-specific training in this area, she and her coauthors developed an interactive workshop using real-world scenarios to help clinicians identify and respond to microaggressions. The conversation explores examples such as mispronouncing ethnic names, assumptions about patient behavior, and misuse of pronouns, along with the workshop's early results, which showed increased participant confidence and awareness. Rhett also discusses the study's limitations, future plans to expand the training, and the importance of fostering more inclusive and respectful healthcare environments.   Show notes JPO article: Examining the Impact of Microaggressions in Healthcare and the Efficacy of Microaggressions Education in Orthotics and Prosthetics O&P Research Insights is produced by Association Briefings.

Show Summary On today's episode, we're having a conversation with Bill Birnie, a retired Marine Corps Sergeant Major, CEO of Frontwave Credit Union, and member of the PsychArmor Board of Directors. We have a great conversation about serving those who served, promoting financial stability, and brining his expertise in the financial sector to the board of PsychArmor. Provide FeedbackAs a dedicated member of the audience, we would like to hear from you. If you PsychArmor has helped you learn, grow, and support those who've served and those who care for them, we would appreciate hearing your story. Please follow this link to share how PsychArmor has helped you in your service journey Share PsychArmor StoriesAbout Today's GuestBill Birnie's lifelong dedication to serving the military community, coupled with his extensive leadership and financial expertise, makes him an outstanding candidate for our PsychArmor Board. A 25-year veteran of the U.S. Marine Corps, Bill retired in 1997 as a Sergeant Major, having served in combat operations during Operation Desert Storm and Operation United Shield. His military career also included assignments as a Marine guard and detachment commander at U.S. Embassies worldwide, where he cultivated a deep understanding of service, leadership, and teamwork.Transitioning from military service, Bill brought his strategic mindset to the credit union industry, where he has built a remarkable 26-year career. Currently, as President and CEO of Frontwave Credit Union, he leads a $1.4 billion institution dedicated to empowering military families and veterans. Bill's leadership, understanding of financial systems, combined with his ability to create sustainable growth, aligns with our strategic needs, and will support our long-term vision.   Bill has served on Boards that address the unique needs of military families and veterans, including as Chairman of the Defense Credit Union Council and Vice Chair of the Armed Forces Financial Network. His experience as a Western Credit Union Management School graduate and 15 years as a faculty member further underscores his ability to mentor and guide organizations toward financial and operational excellence. In his spare time, Bill enjoys golf, traveling and attending theater or concerts with family and friends.  With his unparalleled military and leadership experience, Bill Birnie brings the expertise and insight to strengthen PsychArmor's mission, ensuring it continues to create meaningful impact for the military and veteran community. Links Mentioned in this Episode Frontwave Credit Union WebsiteFrontwave Credit Union Military ResourcesPsychArmor Resource of the WeekThis week's resource of the week is the Preparing Your Finances for Transition.In this course, service members, Veterans and their families will learn about some major financial considerations associated with transition, as well as five useful tips for preparing their finances. You can find the resource here:  https://learn.psycharmor.org/courses/Preparing-Your-Finances-for-Transition Episode Partner: Are you an organization that engages with or supports the military affiliated community? Would you like to partner with an engaged and dynamic audience of like-minded professionals? Reach out to Inquire about Partnership Opportunities Contact Us and Join Us on Social Media Email PsychArmorPsychArmor on TwitterPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families.  You can find more about the work that he is doing at www.veteranmentalhealth.com  

What if the anxiety, overthinking, people pleasing, emotional shutdown, hypervigilance, burnout, and relationship struggles you experience today… were never actually "you" to begin with? In this deeply personal and profoundly eye-opening solo episode, Darin Olien dives into the hidden nervous system programming formed between the ages of 0 and 8 that silently shapes our adult lives. Drawing from neuroscience, trauma research, attachment theory, epigenetics, somatic healing, and his own emotional breakthroughs, Darin explores how childhood experiences become subconscious operating systems that influence everything from relationships and stress responses to chronic disease and self-worth. This episode is a powerful roadmap toward healing. Darin breaks down the science behind trauma, the ACE study, nervous system dysregulation, emotional patterning, and neuroplasticity, while also sharing practical tools like somatic experiencing, expressive writing, EMDR, and Internal Family Systems to help listeners begin rewiring their emotional lives from the inside out. What You'll Learn How childhood experiences program the nervous system Why most adult emotional reactions are subconscious survival patterns The connection between trauma, stress hormones, and chronic disease How the nervous system stores emotional experiences in the body Why people pleasing, hypervigilance, burnout, and emotional shutdown develop The science behind neuroplasticity and rewiring the brain What the ACE Study revealed about childhood trauma and adult health How trauma impacts the amygdala, hippocampus, and stress-response systems Why emotional patterns are adaptations, not character flaws How epigenetics can pass trauma responses across generations The role of somatic experiencing in trauma healing Practical tools for emotional regulation and nervous system repair Chapters 00:00:03 – Welcome to SuperLife 00:00:32 – Sponsor: Bite Toothpaste and eliminating toxic plastic exposure 00:02:47 – Darin introduces emotional reactions and nervous system triggers 00:03:15 – A personal story about reacting vs responding in conflict 00:03:50 – Emotional shutdowns, rage, withdrawal, people pleasing, and overcorrection 00:04:19 – Darin's physical pain journey and emotional discoveries in 2025 00:04:42 – Birth trauma, childhood conditioning, and nervous system programming 00:05:04 – Why the ages of 0–8 are the most neurologically influential years 00:05:18 – Theta and delta brainwave states during childhood 00:05:55 – How children absorb emotional patterns without filters 00:06:22 – Childhood experiences becoming subconscious operating systems 00:06:44 – Adults unknowingly living through a 5-year-old nervous system 00:07:12 – Why this episode became deeply personal for Darin 00:07:35 – The neuroscience behind stress responses and emotional conditioning 00:08:17 – Brain development, neuroplasticity, and subconscious programming 00:09:13 – How the HPA axis, amygdala, and prefrontal cortex are shaped early in life 00:09:45 – Core childhood questions that program the nervous system 00:10:29 – Why adult stress responses originate in childhood environments 00:11:05 – Research showing childhood adversity alters brain structure and chemistry 00:11:18 – The ACE Study explained 00:11:49 – Why patients losing weight became emotionally overwhelmed 00:12:18 – The ten categories of adverse childhood experiences 00:13:02 – "The health crisis of America begins in childhood" 00:13:36 – How adverse childhood experiences increase disease risk 00:14:03 – Suicide, alcoholism, autoimmune disease, depression, and trauma correlations 00:14:37 – Chronic disease as a nervous system issue 00:15:04 – Survival mode, inflammation, hormonal dysregulation, and emotional scarcity 00:15:42 – Self-sabotage and emotional coping patterns explained 00:16:02 – Why your emotional patterns are not character flaws 00:16:22 – Childhood survival adaptations and nervous system intelligence 00:16:52 – Hypervigilance, people pleasing, rage, emotional shutdown, and fear 00:17:05 – Sponsor: Manna Vitality and frequency-based wellness 00:18:59 – Epigenetics and inherited trauma responses 00:19:22 – Cortisol regulation genes and hyperactive stress responses 00:19:51 – Holocaust survivors, inherited trauma, and generational nervous systems 00:20:19 – Why healing requires nervous system awareness—not just intellectual understanding 00:20:45 – "You were never supposed to get over it—you were supposed to heal from it" 00:21:01 – Real-life examples of subconscious nervous system programming 00:21:16 – Why receiving compliments can feel unsafe 00:21:30 – Darin's personal struggle with overachievement and scarcity programming 00:22:03 – Emotional neglect, chronic striving, and feeling "not enough" 00:22:16 – The nervous system roots of burnout and exhaustion 00:22:23 – Hair-trigger emotional reactions and hyperactive amygdala responses 00:22:38 – Chronic self-abandonment and losing personal boundaries 00:22:52 – Fear of intimacy, trust issues, and emotional safety 00:23:02 – "The body keeps the score" explained 00:23:22 – Trauma stored in posture, breath, digestion, immunity, and emotional regulation 00:23:43 – Harvard research on trauma-related brain changes 00:24:19 – The radical power of neuroplasticity and nervous system rewiring 00:24:48 – Why healing requires conscious participation 00:25:01 – Darin shares how healing changed decades of emotional pain 00:25:33 – Somatic Experiencing and Peter Levine's trauma work 00:25:57 – How animals discharge stress naturally 00:26:23 – Trauma as incomplete physiological responses frozen in the body 00:26:42 – Why humans suppress emotional discharge 00:27:16 – PTSD research and the effectiveness of somatic experiencing 00:27:41 – A step-by-step somatic grounding practice 00:28:14 – Why healing is more powerful with a regulated person beside you 00:28:38 – EMDR and reprocessing traumatic experiences 00:28:55 – Internal Family Systems and the "parts" inside the psyche 00:29:13 – Inner critics, overachievers, and nervous system adaptations 00:29:39 – Compassionately listening to emotional parts instead of suppressing them 00:29:51 – Expressive writing as a trauma healing practice 00:30:22 – The neuroscience behind emotional journaling 00:30:48 – A four-day expressive writing protocol for healing 00:31:05 – "You are not broken" 00:31:16 – Reprogramming the nervous system through love and safety 00:31:37 – Why deep healing happens in the presence of another regulated person 00:31:52 – Darin considers creating a future healing workshop 00:32:04 – Final reflections: "You are not what happened to you" 00:32:12 – Peace. Love. SuperLife. Thank You to Our Sponsors Bite Toothpaste: Go to trybite.com/DARIN20 or use code DARIN20 for 20% off your first order Manna Vitality: Go to mannavitality.com/ and use code DARIN12 for 12% off your order. Join the SuperLife Patreon: This is where Darin now shares the deeper work: - weekly voice notes - ingredient trackers - wellness challenges - extended conversations - community accountability - sovereignty practices Join now for only $7.49/month at https://patreon.com/darinolien     Connect with Darin Olien: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Platform & Products: superlife.com New Show: Roadmap to Happiness Key Takeaway "The emotional patterns, fears, reactions, and coping mechanisms that run your adult life are often survival adaptations created by your nervous system during childhood. They are not your identity. They are not permanent. And through awareness, somatic healing, emotional processing, nervous system regulation, and conscious repetition, those deeply rooted patterns can be rewritten into something healthier, freer, and more aligned with who you truly are." Bibliography/Sources Neuroscience & Early Programming Agorastos, A., Pervanidou, P., Chrousos, G. P., & Baker, D. G. (2019). Developmental trajectories of early life stress and trauma: A narrative review on neurobiological aspects beyond stress system dysregulation. Frontiers in Psychiatry, 10, Article 118. https://doi.org/10.3389/fpsyt.2019.00118 Bolton, J. L., Short, A. K., Simeone, K. A., Daglian, J., & Baram, T. Z. (2019). Programming of stress-sensitive neurons and circuits by early-life experiences. Frontiers in Behavioral Neuroscience, 13, Article 30. https://doi.org/10.3389/fnbeh.2019.00030 Shonkoff, J. P., & Boyce, W. T. (2024). Toxic stress and developmental programming of the HPA axis. Annual Review of Developmental Psychology. https://www.annualreviews.org/journal/devpsych Teicher, M. H., & Ohashi, K. (2023). Childhood trauma and reduced hippocampal, anterior cingulate, and corpus callosum volumes. JAMA Psychiatry. https://jamanetwork.com/journals/jamapsychiatry van der Kolk, B. A. (2014). The body keeps the score: Brain, mind, and body in the healing of trauma. Viking / Penguin. https://www.penguinrandomhouse.com/books/313183/the-body-keeps-the-score-by-bessel-van-der-kolk-md/ ACE Study & Adverse Childhood Experiences Felitti, V. J. (2002). The relation between adverse childhood experiences and adult health: Turning gold into lead. The Permanente Journal, 6(1), 44–47. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112216/ Felitti, V. J., & Anda, R. F. (2010). The relationship of adverse childhood experiences to adult health, well-being, social function, and healthcare. In R. Lanius, E. Vermetten, & C. Pain (Eds.), The impact of early life trauma on health and disease (pp. 77–87). Cambridge University Press. https://doi.org/10.1017/CBO9780511777042 Hillis, S., Mercy, J., Amobi, A., & Kress, H. (2023). Economic burden of health conditions associated with adverse childhood experiences among U.S. adults. JAMA Network Open, 6(12). https://jamanetwork.com/journals/jamanetworkopen Liu, Y., Croft, J. B., Chapman, D. P., et al. (2013). Associations between adverse childhood experiences and health outcomes in adults aged 18–59 years. PLOS ONE, 8(3), e58625. https://doi.org/10.1371/journal.pone.0058625 Epigenetics & Trauma Baratta, M. V., et al. (2021). Epigenetics of childhood trauma: Long term sequelae and potential for treatment. Neuroscience & Biobehavioral Reviews, 132, 1049–1063. https://doi.org/10.1016/j.neubiorev.2021.09.043 Jiang, S., Postovit, L., Cattaneo, A., Binder, E. B., & Aitchison, K. J. (2019). Epigenetic modifications in stress response genes associated with childhood trauma. Frontiers in Psychiatry, 10, Article 808. https://doi.org/10.3389/fpsyt.2019.00808 Provençal, N., & Binder, E. B. (2015). The effects of early life stress on the epigenome: From the womb to adulthood and even before. Experimental Neurology, 268, 10–20. https://doi.org/10.1016/j.expneurol.2014.12.001 Healing Modalities — Research Brom, D., Stokar, Y., Lawi, C., et al. (2017). Somatic experiencing for posttraumatic stress disorder: A randomized controlled outcome study. Journal of Traumatic Stress, 30(3), 304–312. https://doi.org/10.1002/jts.22189 Fratarolli, J. (2006). Experimental disclosure and its moderators: A meta-analysis. Psychological Bulletin, 132(6), 823–865. https://doi.org/10.1037/0033-2909.132.6.823 Gilbert, P. (2009). The compassionate mind: A new approach to life's challenges. New Harbinger Publications. https://www.newharbinger.com/9781572248403/the-compassionate-mind/ Justice Resource Institute. (2022). Evaluation of the efficacy of Internal Family Systems (IFS) therapy for trauma-related symptoms among complexly traumatized adults. ClinicalTrials.gov Identifier: NCT05155930. https://clinicaltrials.gov/ct2/show/NCT05155930 Kuhfuß, M., Maldei, T., Hetmanek, A., & Baumann, N. (2021). Somatic experiencing — effectiveness and key factors of a body-oriented trauma therapy. European Journal of Psychotraumatology, 12(1), Article 1929023. https://doi.org/10.1080/20008198.2021.1929023 Levine, P. A. (2010). In an unspoken voice: How the body releases trauma and restores goodness. North Atlantic Books. https://www.northatlanticbooks.com/shop/in-an-unspoken-voice/ Neff, K. D., & Germer, C. K. (2013). A pilot study and randomized controlled trial of the Mindful Self-Compassion Program. Journal of Clinical Psychology, 69(1), 28–44. https://doi.org/10.1002/jclp.21923 Pennebaker, J. W. (1997). Writing about emotional experiences as a therapeutic process. Psychological Science, 8(3), 162–166. https://doi.org/10.1111/j.1467-9280.1997.tb00403.x Rodenburg, R., Benjamin, A., de Roos, C., Meijer, A. M., & Stams, G. J. (2009). Efficacy of EMDR in children: A meta-analysis. Clinical Psychology Review, 29(7), 599–606. https://doi.org/10.1016/j.cpr.2009.06.008 Schwartz, R. C. (2021). No bad parts: Healing trauma and restoring wholeness with the Internal Family Systems model. Sounds True. https://www.soundstrue.com/products/no-bad-parts Shapiro, F. (2017). Eye movement desensitization and reprocessing (EMDR) therapy: Basic principles, protocols, and procedures (3rd ed.). Guilford Press. https://www.guilford.com/books/Eye-Movement-Desensitization-and-Reprocessing/Francine-Shapiro/9781462532766  

Editor-in-Chief Cecelia E. Schmalbach, MD, MSc, is joined by senior author Lee P. Smith, MD, and Associate Editor Christopher Johnson, MD, to discuss the study and approach used to establish a reliable rabbit model of airway stenosis and test how effective nebulized ciprofloxacin/dexamethasone is at reducing airway obstruction , as outlined in the paper "Evaluating the Efficacy of Nebulized Ciprofloxacin-Dexamethasone Using a Novel Model of Airway Stenosis" which published in the May 2026 issue of Otolaryngology–Head and Neck Surgery. Click here to read the full article. Click here to see the visual abstract.  

Cancer immunotherapy has transformed the treatment landscape for many advanced cancers over the past decade. Drugs targeting the PD-1 and PD-L1 pathways are now widely used across several tumor types, helping the immune system recognize and attack cancer cells more effectively. However, researchers are still working to understand how beneficial these therapies may be when used earlier in the disease course, particularly after surgery in patients with high-risk solid tumors. A research paper on this topic was published in Volume 17 of Oncotarget titled “Efficacy and safety of PD-1/ PD-L1 inhibitors as adjuvants in the treatment of patients with solid cancers: A systematic review and meta-analysis of randomized controlled trials.” Full blog - https://www.oncotarget.org/2026/05/20/immune-checkpoint-inhibitors-may-improve-outcomes-in-high-risk-solid-tumors/ Paper DOI - https://doi.org/10.18632/oncotarget.28855 Correspondence to - Dhai Almuteri - d.almuteri@qu.edu.sa Abstract video - https://www.youtube.com/watch?v=4Ce07bHfjB4 Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28855 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, PD-1, PD-L1, adjuvant immunotherapy, solid tumor To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

JCO PO author Dr. Tejas Patil at University of Colorado Cancer Center shares insights into the JCO PO article, "CRESTONE: A Phase II Study of the Efficacy and Safety of the HER3 Monoclonal Antibody, Seribantumab, in Solid Tumors With Neuregulin-1 (NRG1) Fusions". Host Dr. Rafeh Naqash and Dr. Patil discuss the anti-tumor activity and safety data of seribantumab from the CRESTONE study (NCT04383210). LINK TO FULL TRANSCRIPT

Every wireless vendor has an AI story. What actually matters now? Efficacy. Recorded live at Mobility Field Day, Keith sits down with HPE’s Bob Friday right off the show floor to discuss how HPE's announcements are driving toward an autonomous network and what features are the key to truly making a difference in day-to-day life... Read more »

Show SummaryOn today's episode, talking with comedian Brad Bonar, founder of One Degree of Separation, an organization that uses stand-up comedy to spark honest conversations about depression and suicide prevention. We discuss his lived experience, breaking the silence with comedy, and turning their live shows into official training for service members, Veterans and their familiesProvide FeedbackAs a dedicated member of the audience, we would like to hear from you. If you PsychArmor has helped you learn, grow, and support those who've served and those who care for them, we would appreciate hearing your story. Please follow this link to share how PsychArmor has helped you in your service journey Share PsychArmor StoriesAbout Today's GuestBrad Bonar Jr. is the founder and creative force behind 1° of Separation. A seasoned stand-up comedian and magician by trade, Brad has spent nearly 30 years making people laugh around the world. He built a successful entertainment career headlining clubs and corporate shows, including a popular Dry Bar Comedy special that has garnered over 13 million online views. His comedy draws on everyday life and family, and is known for its clean yet keenly observant humor. But beneath the laughter, Brad quietly fought his own battles with depression since childhood.A turning point came a few years ago when Brad discovered an old keepsake: “I found a suicide note that I wrote in the 6th grade,” he recalls. “At first I kinda laughed about it, but then it became very sobering.“ Realizing that he had been struggling in silence for decades, and seeing so many others still doing the same, Brad felt compelled to act. He channeled his talents and insider knowledge of comedy into a deeply personal mission: “I've spent the past 25 years traveling the world making people laugh. Now I'm using my talents for something more personal. It's time to cast a spotlight that removes the stigma of mental illness.” With that, 1 Degree of Separation was born in 2019 as a project to fight depression with comedy.Brad immersed himself in learning about mental health, interviewing doctors and therapists to shape a show that was both funny and responsible in its messaging. He crafted the Five Questions after hours of writing and self-reflection one night. And he recruited fellow comedians (including his wife, Victoria, and others) willing to share their stories on stage. As a performer, Brad has a disarming, warm presence. Audiences often don't expect a comedian to talk about subjects like suicidal ideation, but Brad does so with authenticity and even hope. He frequently opens up about his own experiences – from that sixth-grade note, to a more recent mental health crisis that landed him in a 5150 psychiatric hold, to how “comedy saved me” when he learned to talk about his pain rather than hide it.Today, Brad Bonar Jr. serves as CEO of 1° of Separation, Inc., leading the nonprofit's growth while still touring as one of its headline speakers. Under his leadership, 1° of Separation has gained national attention for its innovative approach (featured on media from local news to podcasts and even military press.) Brad's ability to wear two hats – entertainer and mental health advocate – makes him a unique voice in suicide prevention. He often says, “Laughter changes your brain” and indeed, he's now leveraging laughter to change lives. Brad and his wife Victoria are based in Northern California, but travel constantly for training. When not on the road, he continues to perform traditional comedy and magic shows and is at work on a book about his journey and the intersection of comedy and mental health. In recognition of his efforts, Brad was invited to present at the Department of Defense/VA Suicide Prevention Conference in 2023, where 1° of Separation received a standing ovation from 2,500 professionals. Brad's personal mantra: “Comedy is universal… and if we can laugh at this, we can talk about it," encapsulates the spirit he brings to the cause. He proves that a comedian can change the world, one punchline and one life at a time.Links Mentioned in this Episode 1° of Separation websitePsychArmor Resource of the WeekThis week's resource of the week is the PsychArmor course, Supporting a Veteran in Crisis. This course is designed for businesses to educate them on the differences between their Veteran and civilian employees and ways to support them. You can find the resource here:  https://learn.psycharmor.org/courses/supporting-a-veteran-in-crisis Episode Partner: Are you an organization that engages with or supports the military affiliated community? Would you like to partner with an engaged and dynamic audience of like-minded professionals? Reach out to Inquire about Partnership Opportunities Contact Us and Join Us on Social Media Email PsychArmorPsychArmor on TwitterPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families.  You can find more about the work that he is doing at www.veteranmentalhealth.com  

Every wireless vendor has an AI story. What actually matters now? Efficacy. Recorded live at Mobility Field Day, Keith sits down with HPE’s Bob Friday right off the show floor to discuss how HPE's announcements are driving toward an autonomous network and what features are the key to truly making a difference in day-to-day life... Read more »

Free Candida Guide: https://drruscio.com/guides/get-candida-diet-guide/ Free Home Mold Guide: https://drruscio.com/guides/get-home-mold-guide/   Dr. Ruscio and Dr. Scott discuss a clinical framework for fungus, Candida, and mold as potential drivers of persistent gut, sinus, brain fog, fatigue, and inflammatory symptoms. They cover key diagnostic clues, sinus involvement, blood mold antibodies, sinus CT, limitations of urine mycotoxin testing, and treatment options including diet, probiotics, herbals, biofilm support, sinus therapies, and prescription antifungals.   ✅ Start healing with us! Learn more about our virtual clinic:  https://drruscio.com/virtual-clinic/  

Another positive digoxin trial, another classic coronary physiology study from Imperial College London (ORBITA-FIRE), news in hypertrophic cardiomyopathy, and TAVR done in the wrong patients are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Digoxin in Rheumatic Heart Disease Dig-RHD Trial https://jamanetwork.com/journals/jama/fullarticle/2848973 Safety and Efficacy of Digoxin: Meta-Analysis https://www.bmj.com/content/351/bmj.h4451.long DIGIT-HF Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2415471 DIG Trial https://www.nejm.org/doi/full/10.1056/NEJM199702203360801 RADIANCE Trial https://www.nejm.org/doi/full/10.1056/NEJM199307013290101 II The Physiologic Threshold for Angina ORBITA-FIRE Trial https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.125.078738 III Prediction in Hypertrophic Cardiomyopathy Predictors of Long-Term Outcomes in HCM https://jamanetwork.com/journals/jama/fullarticle/2848800#250998713 IV TAVR Trends in Young Patients Temporal Trends in AVR for Aortic Stenosis in Patients < 65 https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.126.016826 Wall Street Journal article https://www.wsj.com/health/healthcare/heart-valve-tavr-surgery-aorta-1e0eda70 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

LBCT: Efficacy And Safety of Clopidogrel Versus Aspirin Monotherapy Beyond 12 Months After PCI In Patients at High Risk of Subsequent Cardiovascular Event

This week on The Beat, CTSNet Editor-in-Chief Joel Dunning spoke with Dr. Brad Leshnower, Director of Aortic Surgery at Emory University Hospital in Atlanta, GA, USA, about the first implantation of the Gore Ascending Stent Graft in the ARISE III trial for the treatment of an acute type A dissection. Chapters 00:00 Intro 02:26 New CTSNet Website 03:31 JANS 1, Thromboendarterectomy Fellowship 05:28 JANS 2, Sodium-Glucose Cotransporter 2 Inhibitor 07:36 JANS 3, Type A Acute Aortic Dissections 09:51 JANS 4, Asymptomatic Aortic Stenosis at 10 Years 11:46 Video 1, Nuss Procedure w Chrondrotomies 13:08 Video 2, Cardiac Redo Surgery 14:52 Video 3, Uniportal Lobectomy Bronchial Reimplantation 16:13 Dr. Leshnower, Ascending Stent Grafts 32:51 Career Center 33:52 Closing They discussed Dr. Leshnower's experience with this groundbreaking implantation, including the case details such as the patient's medical history, the assessment of the patient's high-risk status, and the criteria for determining their suitability for the procedure. Imaging techniques and the contributions of the other surgeons involved in the case were also highlighted. Furthermore, they delved into the use of the stent in previous ARISE trials and what Dr. Leshnower learned from those early experiences. The conversation also covered topics such as proximal placement, the innominate artery, and the preoperative planning required for the trial. Dr. Leshnower also shared what he learned from this case and discussed the future of the stent graft and this technique. Joel also highlights recent JANS articles on the safety and efficacy of a dedicated pulmonary thromboendarterectomy fellowship, sodium-glucose cotransporter 2 inhibitor use and outcomes after surgical aortic valve replacement, association between surgical timing and postoperative outcomes in type A acute aortic dissection, and early surgery or conservative care for asymptomatic aortic stenosis at 10 years. In addition, Joel explores the Nuss procedure with midline chrondrotomies in severe pectus excavatum, redo surgery for failed MVr, iatrogenic ASD, tricuspid valve regurgitation, and aorta replacement, and uniportal VATS left lower sleeve lobectomy with upper lobe bronchial reimplantation for typical carcinoid tumor. Before closing, Joel highlights upcoming events in CT surgery.   JANS Items Mentioned Safety and Efficacy of a Dedicated Pulmonary Thromboendarterectomy Fellowship: The UK Experience at a High-Volume Center Sodium-Glucose Cotransporter 2 Inhibitor Use and Outcomes After Surgical Aortic Valve Replacement Association Between Surgical Timing and Postoperative Outcomes in TypeAAcute Aortic Dissection Early Surgery or Conservative Care for Asymptomatic Aortic Stenosis at 10 Years  CTSNet Content Mentioned The Nuss Procedure With Midline Chrondrotomies in Severe Pectus Excavatum  Redo Surgery for Failed MVr, Iatrogenic ASD, Tricuspid Valve Regurgitation, and Aorta Replacement  Uniportal VATS Left Lower Sleeve Lobectomy With Upper Lobe Bronchial Reimplantation for Typical Carcinoid Tumor  Other Items Mentioned ARISE III Trial of Gore Ascending Stent Graft Begins Enrollment How to Navigate the New CTSNet Website Career Center CTSNet Events Disclaimer The information and views presented on CTSNet.org represent the views of the authors and contributors of the material and not of CTSNet. Please review our full disclaimer page here.

In this video, Dr. Ruscio discusses 8 benefits of taking butyrate, a fat molecule with gut and systemic healing properties. Butyrate is produced by gut bacteria, but it is often low in different chronic health conditions. Supplementation has been shown to improve a variety of gut conditions, including IBS, IBD, and SIBO, as well as chronic inflammation and brain health. Doctor Ruscio also discusses some simple dietary strategies to increase butyrate production naturally.    ✅ Start healing with us! Learn more about our virtual clinic:  https://drruscio.com/virtual-clinic/  

Show SummaryOn today's episode, we're replaying a conversation with conversation with playwright and producer Elizabeth Coplan, founder of the Greif Dialogues, a nonprofit theatrical movement that facilitates conversations about dying, death, and grief. We talk about her own connection to service and discuss how Grief Dialogues has developed a specific immersive experience of remembrance and reflection ahead of Memorial DayProvide FeedbackAs a dedicated member of the audience, we would like to hear from you. If you PsychArmor has helped you learn, grow, and support those who've served and those who care for them, we would appreciate hearing your story. Please follow this link to share how PsychArmor has helped you in your service journey Share PsychArmor StoriesAbout Today's GuestElizabeth Coplan is a veteran of marketing and public relations with over four decades of experience. She began her professional journey as an aspiring actor in New York City in 1972 before pivoting to publishing, eventually becoming the managing editor of Chief Executive Magazine. After relocating to California, she climbed the ranks at Collins Foods International, ultimately serving as Director of Corporate Communications.In Seattle, Elizabeth became a trailblazer in professional services marketing, notably serving as the first Northwest marketing director for Touché Ross (now Deloitte). She later became Director of Client Service and Development at Davis Wright Tremaine, where she helped grow the firm from three to ten offices and pioneered strategic sponsorships in the legal sector. After six years, she launched her own consulting firm, advising major clients including Merrill Lynch and the University of Washington School of Law.Her service on nonprofit boards includes the Bainbridge Island Museum of Art and the Intiman Theatre, where she chaired strategic planning. In 2013, after a series of personal losses, Elizabeth began writing to process her grief. This led to the creation of Grief Dialogues, a groundbreaking play and nonprofit initiative that fosters dialogue about death and grief through theatre.Her award-winning works include Hospice: A Love Story, Untold, The Choice, and Honoring Choices, the latter adapted into a film that premiered in Los Angeles and earned multiple festival awards. She also directed and produced Juntos Nos Ayudamos, a film addressing suicide in a Hispanic family, and co-hosts the podcast Out of Grief Comes Art.Elizabeth's writing appears in professional grief therapy publications, and her full-length play 'Til Death premiered Off-Broadway in 2023 with an acclaimed cast. She is currently working on The Book Club, a new play exploring the lives of senior women.Links Mentioned in this Episode Grief Dialogues WebsiteMy Guardian Angel MoviePsychArmor Resource of the WeekThis week's resource of the week is the PsychArmor course, Good Grief. Grief is not only experienced with death, it can also occur with job loss or severe changes to physical well-being. The purpose of this course is to recognize loss and identify what is learned as a result of that loss. You can find the resource here:  https://learn.psycharmor.org/courses/good-grief Episode Partner: Are you an organization that engages with or supports the military affiliated community? Would you like to partner with an engaged and dynamic audience of like-minded professionals? Reach out to Inquire about Partnership Opportunities Contact Us and Join Us on Social Media Email PsychArmorPsychArmor on TwitterPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families.  You can find more about the work that he is doing at www.veteranmentalhealth.com  

Amyotrophic lateral sclerosis (ALS), which affects about 25 000 individuals in the US, causes progressive weakness but has varied presentations. Several FDA-approved medications are now available for ALS. Author John Ravits, MD, of UC San Diego School of Medicine joins JAMA Deputy Editor Mary M. McDermott, MD, to discuss current evidence regarding diagnosis and treatment of ALS. Related Content: Amyotrophic Lateral Sclerosis Pridopidine in Amyotrophic Lateral Sclerosis What Is Amyotrophic Lateral Sclerosis? CNM-Au8 in Amyotrophic Lateral Sclerosis Safety and Efficacy of PrimeC in Amyotrophic Lateral Sclerosis Traumatic Brain Injury and Risk of Amyotrophic Lateral Sclerosis

Podcast moderator Lejla Vajzovic, MD, sits down with Robert L. Avery, MD; Carl D. Regillo, MD; and Durga S. Borkar, MD, MMCi, to explore how new therapies hold promise for extending treatment efficacy in patients with wet AMD. They touch on various drug delivery platforms, gene therapy, tyrosine kinase inhibitors, and the challenges of drug development and approval. 

In this week's episode, Blood editor Dr. Laura Michaelis interviews Dr. Alexis Thompson, former ASH president, on her latest article published in Blood. Dr. Thompson discusses "Long-term efficacy and safety results of betibeglogene autotemcel gene therapy for transfusion-dependent β-thalassemia." She explains transfusion-dependent β-thalassemia (TDT) requires rigorous, lifelong transfusion therapy and iron chelation to manage iron overload. Dr. Kwiatkowski and colleagues discuss the long-term efficacy and safety of this gene therapy in 63 patients with TDT, documenting sustained transfusion independence for up to 10 years and a safety profile consistent with that of myeloablative autologous transplantation.

A fascinating Lancet RCT shows once-weekly semaglutide may redefine alcohol use disorder treatment.

Show SummaryOn today's episode, we're having a conversation with Verenice Castillo, founder of the Military Spouse Advocacy Network, an organization dedicated to supporting military spouses through mentorship, leadership development, and community-building. Drawing from her own experience as an immigrant and longtime military spouse, Verenice has built MSAN into a global network focused on reducing isolation and empowering spouses to find purpose and connection.Provide FeedbackAs a dedicated member of the audience, we would like to hear from you. If you PsychArmor has helped you learn, grow, and support those who've served and those who care for them, we would appreciate hearing your story. Please follow this link to share how PsychArmor has helped you in your service journey Share PsychArmor StoriesAbout Today's GuestsVerenice Castillo is the Founder and CEO of the Military Spouse Advocacy Network (MSAN), a nonprofit organization she launched to address the persistent challenges of isolation, lack of community, and limited professional opportunities faced by military spouses. Originally from Mexico, Castillo immigrated to the United States as a teenager and later became a military spouse, an experience that shaped her commitment to advocacy and peer support.Over more than a decade, she has grown MSAN into a nationally recognized organization providing mentorship, leadership training, and mental wellness resources to military spouses worldwide. Castillo has led initiatives such as the Leadership Institute for Military Spouses, in collaboration with institutions like Harvard University and University of Notre Dame, equipping hundreds of spouses each year with skills in leadership, crisis response, and ethical decision-making. Her work has positioned her as a leading voice in military spouse advocacy, particularly around issues of community connection, career development, and mental health.Links Mentioned During the EpisodeMSAN WebsiteLeadership Institute for Military SpousesPsychArmor Resource of the WeekThis week's PsychArmor Resource of the week is the PsychArmor course Networking for Military Spouses. This course will help you define what networking means, demonstrate ways to incorporate social media into your networking task, and list tips for better networking results.You can find the resource here:https://learn.psycharmor.org/courses/Networking-for-Military-Spouses Episode Partner: Are you an organization that engages with or supports the military affiliated community? Would you like to partner with an engaged and dynamic audience of like-minded professionals? Reach out to Inquire about Partnership Opportunities Contact Us and Join Us on Social Media Email PsychArmorPsychArmor on XPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families.  You can find more about the work that he is doing at www.veteranmentalhealth.com  

In his weekly clinical update, Dr. Griffin and Vincent Racaniello note the uncertain future of the National Science Foundation amid shifting U.S. funding priorities and governance; the rise of China as a global research powerhouse; ongoing advances and controversies in vaccines shaped by the World Health Organization and the Centers for Disease Control and Prevention; vaccine policy battles in Florida; European approval of the moderna mCOMBRIAX, COVID-19 and influenza vaccine, the mounting evidence supporting preventive vaccination strategies including that for HPV and the HepB birth dose; the spread of drug-resistant infections and the resurgence of HIV in Zambia; and the enduring public trust in scientists despite political turbulence, before Dr. Griffin deep dives into the measles outbreak, recent statistics RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, the efficacy of the influenza vaccine for children, PEMGARDA authorized use for certain immunocompromised individuals where to find PEMGARDA, how to access and pay for Paxlovid, use of remdesivir for RSV, how administration of Paxlovid did not affect hospitalization of high-risk vaccinated patients, where to go for answers about long COVID-19, if SARS-CoV-2 infection may facilitate EBV reactivation, exercise for treating long COVID and contacting your federal government representative to stop the assault on science and biomedical research. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Entire NSF science advisory board fired by Trump administration (Nature) United States v. Arthrex, Inc.(Harvard Law Review) United States v. Arthrex Inc. [SCOTUSbrief] (Federalist Society) China could be the world's biggest public funder of science within two years (Nature) The Vaccine Skeptic in Trump's New C.D.C. Leadership Team (NY Times) World Immunization week: Largest catch-up initiative delivers over 100 million childhood vaccinations (WHO) Pigs are flying!: Florida Republicans refuse to take up DeSantis bill loosening vaccine mandates (NY Times) Moderna Receives European Commission Marketing Authorization for mCOMBRIAX, Moderna's mRNA Combination Vaccine Against Influenza and COVID-19(moderna) America First! AIDS Creeps Back in Parts of Zambia, a Year After U.S. Cuts to H.I.V. Assistance (NY Times) Emergence of Extensively Drug-Resistant Shigellosis — United States, 2011–2023 (CDC: MMWR) Scientists Esteemed by Public, with Vaccine Scientists Seen as Similar to Scientists in General (Annenberg: Public Policy Center, University of Pennsylvania) RFK Jr. is holding up $600M in vaccines for poor countries (Politico) Trump Withdraws Nomination of Casey Means for Surgeon General (NY Times) What? Benefit of preventive strategies like vaccination? Incidence of human papillomavirus infections in women aged 27 years and older in the US: A federated data network study (International Journal of Infectious Diseases) Economic Impact of Delaying the Infant Hepatitis B Vaccination Schedule (JAMA Pediatrics) Impact of Removing the Universal Hepatitis B Birth-Dose Vaccination in the US (JAMA Pediatrics) Wastewater for measles (WasterWater Scan) Measles cases and outbreaks (CDC Rubeola) Measles Dashboard (South Carolina Department of Public Health) Utah measles outbreak response (Utah Department of Health and Human Services) Utah Measles Dashboard (Utah Department of Health and Human Services) Tracking Measles Cases in the U.S. (Johns Hopkins) Measles vaccine recommendations from NYP (jpg) Weekly measles and rubella monitoring (Government of Canada) Measles (WHO) Get the FACTS about measles (NY State Department of Health) Measles (CDC Measles (Rubeola)) Measles vaccine (CDC Measles (Rubeola)) Presumptive evidence of measles immunity (CDC) Contraindications and precautions to measles vaccination (CDC) Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) Deaths following vaccination: what does the evidence show (Vaccine) Dangers of measles infection (NY Times) Influenza: Waste water scan for 11 pathogens (WastewaterSCan) US respiratory virus activity (CDC Respiratory Illnesses) Respiratory virus activity levels (CDC Respiratory Illnesses) Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP) FDA vaccine advisers recommend adding subclade K to fall shots (CIDRAP) Weekly surveillance report: cliff notes (CDC FluView) OPTION 2: XOFLUZA $50 Cash Pay Option (Xofluza) Influenza Vaccination Coverage Among Nursing Home Residents and Health Care Personnel — United States, 2024–25 Influenza Season (CDC: MMWR) Pediatric Vaccine Effectiveness Against Influenza Hospitalization And Outpatient Visits: 2021–2024 (Pediatrics) Influenza Vaccine Effectiveness in European Primary Care Pediatric Practices: 2022–2024 (Pediatrics) RSV: Waste water scan for 11 pathogens (WastewaterSCan) Respiratory Diseases (Yale School of Public Health) USrespiratory virus activity (CDC Respiratory Illnesses) RSV-Network (CDC Respiratory Syncytial virus Infection) Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) Respiratory Diseases (Yale School of Public Health) Impact of universal nirsevimab prophylaxis in infants on hospital and primary care outcomes across two respiratory syncytial virus seasons in Galicia, Spain (NIRSE-GAL): a population-based prospective observational study (LANCET: Infectious Diseases) First Report on Remdesivir Use for the Treatment of Respiratory Syncytial Virus in Five Allogeneic Hematopoietic Cell Transplant Recipients (JID) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 deaths (CDC) Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) COVID-19 national and regional trends (CDC) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) Infusion center (Prime Fusions) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Oral Nirmatrelvir–Ritonavir for Covid-19 in Higher-Risk Outpatients(NEJM) Same Pill, Different Impact — Reassessing the Efficacy of Nirmatrelvir–Ritonavir(NEJM) Paxlovid doesn't reduce hospitalization, death rates in vaccinated high-risk COVID outpatients, trial shows (CIDRAP) Drug interaction checker (University of Liverpool) Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) UnderstandingCoverage Options (PAXCESS) Infectious Disease Society guidelines for treatment and management (ID Society) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) Managing healthcare staffing shortages (CDC) Anticoagulation guidelines (hematology.org) Daniel Griffin's evidence based medical practices for long COVID (OFID) Long COVID hotline (Columbia: Columbia University Irving Medical Center) The answers: Long COVID Acute COVID-19 is associated with altered CD8 T-cells indicative of impaired ability to control Epstein–Barr virus reactivation (Medical Microbiology and Immunology) Exercise and Weekly Sirolimus (Rapamycin) in Older Adults: RAPA-EX-01 Randomised, Double-Blind, Placebo-Controlled Trial (Journal of Cachexia, Sarcopenia and Muscle) Reaching out to US house representative Letters read on TWiV 1318 Dr. Griffin's COVID treatment summary (pdf) Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to daniel@microbe.tv Content in this podcast should not be construed as medical advice.