Podcasts about Efficacy

This episode is powered by LightpathLED, a trusted provider of professional-grade red and blue light therapy panels. As Nurse Doza shares, he's used red light therapy every day for over six years — both in his clinic and at home — and now relies on LightpathLED's dual-wavelength panel for enhanced skin health, mood support, and cellular energy production. If you're ready to invest in a panel backed by a clinician's daily use, LightpathLED is the brand Nurse Doza recommends to his patients, family, and friends.

Welcome back to the Flex Diet Podcast! In this episode, I chat with Dr. Eric Rawson about the fascinating world of creatine, not just for muscle growth and performance, but also for brain health. We review the latest research on how creatine supplementation may affect brain function, support concussion recovery, and more. Dr. Rawson shares insights from his extensive research, highlights the amazing safety profile of creatine monohydrate, and offers practical advice on supplementation for athletes and those at high risk of traumatic brain injuries. Tune in for an in-depth look at the science and practical applications of this powerful supplement! Don't forget to subscribe and share with friends. Enjoy!Sponsors:Fitness Insider Newsletter: https://miketnelson.com/Enroll in the Flex Diet Certification by midnight PST on Monday, Feb. 16.https://miket.me/fdcAvailable now:Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here.Episode Chapters:01:25 Creatine's Evolution and Its New Applications02:37 Creatine and Cognitive Function04:29 Podcast Logistics and Listener Engagement05:31 Rebroadcast: Dr. Eric Rawson on Creatine and Brain Health07:34 Dr. Rawson's Background and Research Focus17:21 Challenges in Measuring Brain Creatine26:53 Animal Models vs. Human Data34:18 Challenges in Brain Function Research36:14 Political and Reporting Issues in Concussion Studies37:40 Open-Label Trials and Self-Report Surveys39:56 Creatine's Potential in Brain Injury Recovery42:25 Parental Concerns and Misconceptions about Creatine44:45 The Safety and Efficacy of Creatine47:09 Future Directions in Creatine Research48:53 Comparing Brain and Muscle Creatine Levels52:53 The Need for Human Studies Over Animal Models55:33 The Broad Appeal of Creatine58:57 Conclusion and Final ThoughtsGet In Touch with Dr Mike:Instagram: DrmiketnelsonYouTube: @flexdietcertEmail: Miketnelson.com/contact-us

Featuring a slide presentation and related discussion from Dr Marwan Fakih, including the following topics: Overview of etiology, incidence and staging of squamous cell cancer of the anal canal (SCAC) (0:00) Systemic therapy approaches to the management of recurrent unresectable and metastatic SCAC (6:17) Available data with anti-PD-1 (pembrolizumab, nivolumab, retifanlimab) and anti-CTLA-4 (ipilimumab) agents in the management of unresectable metastatic SCAC previously treated with chemotherapy (12:59) Immunotherapy combined with chemotherapy for the front-line treatment of SCAC (20:48) Efficacy and safety of retifanlimab combined with carboplatin/paclitaxel as first-line treatment for SCAC in the Phase III POD1UM-303 trial (23:43) CME information and select publications

Show SummaryOn this episode, we have a conversation Today we're having a conversation with Jesse Gould, founder of the Heroic Hearts Project and a former Army Ranger, about what it means for veterans to heal when traditional systems don't have all the answers. Heroic Hearts works with leading medical researchers to improve veterans access to psychedelic programs for the treatment of PTSD.Provide FeedbackAs a dedicated member of the audience, we would like to hear from you. If you PsychArmor has helped you learn, grow, and support those who've served and those who care for them, we would appreciate hearing your story. Please follow this link to share how PsychArmor has helped you in your service journey Share PsychArmor StoriesAbout Today's GuestJesse Gould is Founder and President of the Heroic Hearts Project, a 501(c)(3) nonprofit pioneering psychedelic therapies for military veterans. After being deployed as an Army Ranger in Afghanistan three times, he founded the Heroic Hearts Project in 2017 to spearhead the acceptance and use of ayahuasca therapy as a means of addressing the current mental health crisis among veterans. The Heroic Hearts Project has raised over $350,000 in scholarships from donors including Dr. Bronner's and partnered with the world's leading ayahuasca treatment centers, as well as sponsoring psychiatric applications with the University of Colorado Boulder and the University of Georgia.  Jesse helps shape treatment programs and spreads awareness of plant medicine as a therapeutic method. He has spoken globally about psychedelics and mental health, and received accolades including being recognized as one of the Social Entrepreneurs To Watch For In 2020 by Cause Artist. Driven by a mission to help military veterans struggling with mental trauma, he is best known for his own inspiring battle with PTSD and his recovery through ayahuasca therapy. Jesse's work can be seen and heard at NY Times, Breaking Convention, San Francisco Psychedelic Liberty Summit, People of Purchase, The Freq, Psychedelics Today Podcast, Kyle Kingsbury Podcast, Cause Artist, and The GrowthOp. Links Mentioned During the EpisodeHeroic Hearts Project WebsiteThe Veterans Guide to Psychedelics on AmazonThe Veteran's Field Manual for Psychedelics on Amazon PsychArmor Resource of the WeekThis week's PsychArmor Resource of the Week the PsychArmor Veteran Ready program. This program offers a short, self-paced online training experience that builds foundational understanding of military culture and practical skills for supporting Veterans, service members, and their families with respect and confidence. Large organizations like the Coast Guard Chief Petty Officers Association can partner with PsychArmor to provide this military-cultural education to their members, helping teams, departments, and entire workforces become more Veteran Ready and better connected to the military-connected community.. You can find the resource here: https://learn.psycharmor.org/pages/veteran-ready Episode Partner: Are you an organization that engages with or supports the military affiliated community? Would you like to partner with an engaged and dynamic audience of like-minded professionals? Reach out to Inquire about Partnership Opportunities Contact Us and Join Us on Social Media Email PsychArmorPsychArmor on XPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families.  You can find more about the work that he is doing at www.veteranmentalhealth.com  

PodChatLive 216: Paediatric flat foot, Homeopathy for calcaneal spurs, & Ostenil in the penisContact us: getinvolved@podchatlive.comLinks from this episode:Efficacy of Individualized Homeopathic Medicines in Managing Pain of Calcaneal SpurPrevalence and modifiable risk factors for pediatric flatfoot among schoolchildren in Kunming and KandaharNewly discovered Michelangelo foot sketch sells for £16.9m

In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden interviews Tamim Hamid, a biomedical engineer who transitioned from NASA to developing a revolutionary hair regrowth laser helmet. The conversation delves into the science of hair loss, the role of lasers in stimulating hair regrowth, and the impact of fungal infections on scalp health. Hamid explains the importance of using anti-fungal shampoos in conjunction with laser therapy for optimal results. He also discusses the limitations of traditional hair loss treatments like minoxidil and finasteride, highlighting the superior efficacy of his laser technology. The episode concludes with practical advice on maintaining scalp health and the future of hair regrowth technology.   For Audience ·       Use code 'Podcast10' to get 10% OFF on any of our supplements at https://gladdenlongevityshop.com/ !    Takeaways ·       Tamim Hamid transitioned from NASA to hair regrowth technology. ·       The laser helmet developed by Hamid uses 80 lasers for hair regrowth. ·       Hair loss is often linked to fungal infections like Malassezia furfur. ·       Anti-fungal shampoos are essential for maintaining scalp health. ·       Laser therapy shows a significant increase in hair count compared to traditional treatments. ·       DHT is a major factor in hair loss, exacerbated by inflammation. ·       The Theradome helmet is designed for easy use and effective treatment. ·       Regular use of anti-fungal shampoo is crucial for optimal results. ·       The helmet treatment protocol involves using it after shampooing every few days. ·       Hamid's book 'Grow Back' provides comprehensive insights into hair regrowth.   Chapters 00:00 Introduction to Hair Regrowth Innovations 07:18 From Space to Hair: A Unique Journey 08:53 The Science Behind Laser Hair Regrowth 16:16 Understanding Fungal Influence on Hair Loss 21:33 Combating Hair Loss: The Role of DHT and Treatments 23:56 Maintaining Scalp Health for Optimal Hair Growth 29:30 The Efficacy of Laser Phototherapy vs. Traditional Treatments 33:11 Understanding Hair Follicle Regeneration 34:54 The Role of Biotin in Hair Health 36:07 Accessing Theradome Products and Resources   To learn more about Tamim Hamid: Email:  tamim@theradome.com Website: https://theradome.com/ Instagram: https://www.instagram.com/theradome/   Reach out to us at:    Website: https://gladdenlongevity.com/     Facebook: https://www.facebook.com/Gladdenlongevity/    Instagram: https://www.instagram.com/gladdenlongevity/?hl=en     LinkedIn: https://www.linkedin.com/company/gladdenlongevity    YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw      Gladden Longevity Podcast Disclosures Production & Independence The Gladden Longevity Podcast and Age Hackers are produced by Gladden Longevity Podcast, which operates independently from Dr. Jeffrey Gladden's clinical practice and research at Gladden Longevity in Irving, Texas. Dr. Gladden may serve as a founder, advisor, or investor in select health, wellness, or longevity-related ventures. These may occasionally be referenced in podcast discussions when relevant to educational topics. Any such mentions are for informational purposes only and do not constitute endorsements. Medical Disclaimer The Gladden Longevity Podcast is intended for educational and informational purposes only. It does not constitute the practice of medicine, nursing, or other professional healthcare services — including the giving of medical advice — and no doctor–patient relationship is formed through this podcast or its associated content. The information shared on this podcast, including opinions, research discussions, and referenced materials, is not intended to replace or serve as a substitute for professional medical advice, diagnosis, or treatment. Listeners should not disregard or delay seeking medical advice for any condition they may have. Always seek the guidance of a qualified healthcare professional regarding any questions or concerns about your health, medical conditions, or treatment options. Use of information from this podcast and any linked materials is at the listener's own risk. Podcast Guest Disclosures Guests on the Gladden Longevity Podcast may hold financial interests, advisory roles, or ownership stakes in companies, products, or services discussed during their appearance. The views expressed by guests are their own and do not necessarily reflect the opinions or positions of Gladden Longevity, Dr. Jeffrey Gladden, or the production team. Sponsorships & Affiliate Disclosures To support the creation of high-quality educational content, the Gladden Longevity Podcast may include paid sponsorships or affiliate partnerships. Any such partnerships will be clearly identified during episodes or noted in the accompanying show notes. We may receive compensation through affiliate links or sponsorship agreements when products or services are mentioned on the show. However, these partnerships do not influence the opinions, recommendations, or clinical integrity of the information presented. Additional Note on Content Integrity All content is carefully curated to align with our mission of promoting science-based, ethical, and responsible approaches to health, wellness, and longevity. We strive to maintain the highest standards of transparency and educational value in all our communications.

Sara Daw is Group CEO of The CFO Centre and The Liberti Group, and the author of Strategy and Leadership as Service – How the Access Economy Meets the C-Suite, which explores the fractional leadership trend and the impact on employees. The remote vs in-office workplace debate continues to burden leaders. Return-to-office mandates are on the rise, with the idea that they will boost engagement, productivity and collaboration. But do they? Worryingly, the opposite can be true. A recent Gartner survey found that among high-performing employees, their intent to stay was 16% lower with strict RTO mandates. Conversely, Gallup's latest State of the Global Workplace report reveals that remote workers are the most likely to be engaged at work (31%). Employees Work' Matters Less Than 'How They Work' While it is important for each company to decide what work arrangements work best for them – whether remote, hybrid, or in office full-time – this misses the overarching point. Instead of arguing over the 'where' of work, leaders should be focusing more on the 'how'. This is where "psychological ownership" comes in – our ability to feel that our job belongs to us. When employees feel psychologically tied to their roles, the more likely they are to be engaged and perform at their best. So how can leaders develop psychological ownership in their staff, regardless of where they work from? The Three Roots of Psychological Ownership There are three roots that underpin a sense of psychological ownership – efficacy, self-identity and having a place: 1. Efficacy – leaders, employees and their team members must understand each other's needs and feel confident that the relationship is working to meet desired goals. 2. Self-identity – work isn't just about completing tasks; it's about expressing individual skills, values and purpose. Employees need to feel that their role fits their identity and reflects who they are. 3. Having a place – individuals fundamentally want to belong. When teams work together, individuals feel part of a group of like-minded people with a shared mission, strengthening their commitment and engagement. These three roots are particularly important for a blended workforce, with employees split between working in-office and from home. So, what steps can leaders take to nurture these roots of psychological ownership in their staff? Create Control When staff have a say over their work, they achieve a sense of control in their role. This helps them to feel ownership of their tasks, boosting their motivation, engagement and performance. To increase feelings of control in employees, leaders should: Clarify the purpose and goals of staff's work but let them choose the best way to achieve them. Encourage staff to share their knowledge and insights with others – this strengthens their feeling of control by demonstrating their competence and confidence. Foster open communication channels by determining when individuals are and aren't available Build Intimacy Intimacy is a key ingredient for creating a positive and fulfilling work environment, particularly in a blended workforce. Intimacy leads to a stronger sense of belonging with colleagues, increases collaboration and conflict resolution, and deepens our appreciation of our role, its purpose and its impact. Leaders can build intimacy with and between employees by: Scheduling regular one-to-one meetings and informal catch-ups to check in on each other's well-being, goals, and challenges Be empathetic, actively listen and ask open-ended questions to show interest and understanding Arrange social events and activities that promote getting to know each other outside of work Build trust via transparency, sticking to commitments, and being consistent. Encourage self-investment How much employees invest themselves personally in their work influences their sense of ownership over their jobs. Investment can take many forms – time, skills, ideas, physical and psychological, and intellectual ener...

Doctors Lisa and Sara talk to Consultant Nephrologist Dr Darren Green about patients with Type 2 Diabetes who also have Chronic Kidney Disease and Heart Failure.  We go through a hypothetical case to illustrate some of the finer points of management that can commonly get missed or might not be appreciated. A really detailed talk full of useful practice enhancing tips for this complex group of patients.  Disclaimer: All educational content in this podcast was developed as part of the Circulation Health collaborative working project between Boehringer Ingelheim Limited, Greater Manchester Primary Care Provider Board and Health Innovation Manchester. Content has been created by Circulation Health Clinical Leads for educational purposes, reflecting NHS Clinical Lead and guideline-based recommendations. Boehringer Ingelheim had no input into content development. They have provided financial resources to support Podcast recordings related to this project. Darren would like us to make you all aware that he has working relationships with pharmaceutical industry partners. Specifically, that he has received speak fees and consultancy fees from AstraZeneca, GSK, Novartis, Boehringer Ingelheim, Bayer, and Lilly, and has been part of collaborative working agreements with Novartis, Boehringer Ingelheim, and AstraZeneca. You can use these podcasts as part of your CPD - we don't do certificates but they still count :) Resources: Dr Kevin Fernando counselling diabetic patients starting an SGLT2 Inhibitors like Dapagliflozin or Empagliflozin: https://www.youtube.com/watch?v=pc99SdtlsyU Diabetes UK counselling sheets on SGLT2 inhibitors: https://www.diabetes.org.uk/about-diabetes/looking-after-diabetes/treatments/tablets-and-medication/sglt2-inhibitors Kidney Care UK Patient Booklets: https://kidneycareuk.org/get-support/free-resources/patient-information-booklets/ Pumping Marvellous Heart Failure Charity with patient resources: https://pumpingmarvellous.org/ International Society for Nephrology Toolkit for Initiating or Changing RAASi - Renin Angiotensin Aldosterone System Inhibitors (like ACEis such as Lisinopril or Ramipril, or ARBs like Candesartan on Losartan): https://www.theisn.org/initiatives/toolkits/raasi-toolkit/ Royal College of General Practitioners Acute Renal Failure Toolkit: https://elearning.rcgp.org.uk/course/info.php?id=899 CONFIDENCE trial: Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes | New England Journal of Medicine: https://www.nejm.org/doi/full/10.1056/NEJMoa2410659 ATLAS trial: Efficacy and safety of high-dose lisinopril in chronic heart failure patients at high cardiovascular risk, including those with diabetes mellitus: https://pubmed.ncbi.nlm.nih.gov/11071803/ Metformin lactic acidosis Metformin in Patients With Type 2 Diabetes and Kidney Disease: A Systematic Review: https://jamanetwork.com/journals/jama/article-abstract/2084896 UK AKI Summit report UKKA AKI Summit Report + Recommendations: https://share.google/7uw1GPQ5sV2riJtiV RCGP AKI follow up  post discharge recommendations: https://bjgpopen.org/content/early/2020/06/15/bjgpopen20X101054/tab-figures-data?versioned=true ___ We really want to make these episodes relevant and helpful: if you have any questions or want any particular areas covered then contact us on Twitter @PCKBpodcast, or leave a comment on our quick anonymous survey here: https://pckb.org/feedback Email us at: primarycarepodcasts@gmail.com ___ This podcast has been made with the support of GP Excellence and Greater Manchester Integrated Care Board. Given that it is recorded with Greater Manchester clinicians, the information discussed may not be applicable elsewhere and it is important to consult local guidelines before making any treatment decisions.  The information presented is the personal opinion of the healthcare professional interviewed and might not be representative to all clinicians. It is based on their interpretation of current best practice and guidelines when the episode was recorded. Guidelines can change; To the best of our knowledge the information in this episode is up to date as of it's release but it is the listeners responsibility to review the information and make sure it is still up to date when they listen. Dr Lisa Adams, Dr Sara MacDermott and their interviewees are not liable for any advice, investigations, course of treatment, diagnosis or any other information, services or products listeners might pursue as a result of listening to this podcast - it is the clinicians responsibility to appraise the information given and review local and national guidelines before making treatment decisions. Reliance on information provided in this podcast is solely at the listeners risk. The podcast is designed to be used by trained healthcare professionals for education only. We do not recommend these for patients or the general public and they are not to be used as a method of diagnosis, opinion, treatment or medical advice for the general public. Do not delay seeking medical advice based on the information contained in this podcast. If you have questions regarding your health or feel you may have a medical condition then promptly seek the opinion of a trained healthcare professional.

Show SummaryOn this episode, we have a conversation with Retired Master Chief Petty Officer Rob Bushey, Executive Director of the Coast Guard Chief Petty Officers Association and a 32-year Coast Guard veteran. He shares his perspective on the Coast Guard's unique dual mission and the role that the CGCPOA plays in strengthening connection and advocacy across the Coast Guard.Provide FeedbackAs a dedicated member of the audience, we would like to hear from you. If you PsychArmor has helped you learn, grow, and support those who've served and those who care for them, we would appreciate hearing your story. Please follow this link to share how PsychArmor has helped you in your service journey Share PsychArmor StoriesAbout Today's GuestRob Bushey is the Executive Director of the Coast Guard Chief Petty Officers Association, where he serves as a workforce advocate and organizational leader supporting enlisted Coast Guard members and their families. A 32-year veteran of the U.S. Coast Guard, Rob's career spanned operational law enforcement, search and rescue, drug interdiction, and maritime security missions at sea and abroad. He has served at surf and lifeboat stations on the West Coast, as well as in senior enlisted leadership roles, including overseas assignments in the Middle East supporting joint operations.Throughout his career, Rob has focused on empowering enlisted personnel by advancing professional development, mission readiness, and community engagement. In his current role, he helps lead a national membership organization that advocates for Coast Guard enlisted members, connects leaders and units across the service, and provides programs that address workforce challenges, family needs, and enlisted excellence.Rob holds extensive experience integrating Coast Guard capabilities within broader national security frameworks and is known for strengthening communication between the enlisted force and senior leadership. He lives with his family and remains deeply committed to service, mentorship, and enhancing the effectiveness and wellbeing of the Coast Guard community.Links Mentioned During the EpisodeCoast Guard Chief Petty Officers & Enlisted Association WebsitePsychArmor on USCGCPOA WebsitePsychArmor Resource of the WeekThis week's PsychArmor Resource of the Week the PsychArmor Veteran Ready program. This program offers a short, self-paced online training experience that builds foundational understanding of military culture and practical skills for supporting Veterans, service members, and their families with respect and confidence. Large organizations like the Coast Guard Chief Petty Officers Association can partner with PsychArmor to provide this military-cultural education to their members, helping teams, departments, and entire workforces become more Veteran Ready and better connected to the military-connected community.. You can find the resource here: https://learn.psycharmor.org/pages/veteran-ready Episode Partner: Are you an organization that engages with or supports the military affiliated community? Would you like to partner with an engaged and dynamic audience of like-minded professionals? Reach out to Inquire about Partnership Opportunities Contact Us and Join Us on Social Media Email PsychArmorPsychArmor on XPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families.  You can find more about the work that he is doing at www.veteranmentalhealth.com  

With Felix Lindberg, Karolinska Institutet & Södersjukhuset Hospital, Stockholm – Sweden and Marianna Fontana, National Amyloidosis Center, University College London, London – UK. In this episode, Felix Lindberg and Marianna Fontana discuss the evolving landscape in the treatment of cardiac amyloidosis. After exploring the pathophysiology of cardiac AL and ATTR amyloidosis and recent years' insights about the epidemiology of these conditions, they focus on the transformation that has occurred in the therapeutic options for cardiac ATTR amyloidosis. The conversation addresses the key mechanistic differences and trial data on stabilizers and silencers, how to approach patient selection for these therapies, as well as emerging therapies including anti-amyloid antibodies. The discussion also highlights the importance of early diagnosis and key red flags that should elicit suspicion of cardiac amyloidosis. Suggested reading: Vutisiran in patients with transthyretin amyloidosis with cardiomyopathy. Fontana M, et al. N Engl J Med. 2025. Tafamidis treatment for patients with transthyretin amyloid cardiomyopathy. Maurer M, et al. N Engl J Med. 2018. Efficacy and safety of acoramidis in tranthyretin amyloid cardiomyopathy. Gillmore JD, et al. N Engl J Med. 2024. CRISPR-Cas9 gene editing with nexiguran ziclumeran for ATTR cardiomyopathy. Fontana M, et al. N Engl J Med. 2024. Conventional heart failure therapy in cardiac ATTR amyloidosis. Ioannou A, et al. Eur Heart J. 2023. Nonbiopsy diagnosis of cardiac transthyretin amyloidosis. Gillmore JD, et al. Circulation. 2016. Current landscape of therapies for transthyretin amyloid cardiomyopathy. Griffin JM, et al. JACC Heart Fail. 2025. Transthyretin amyloid cardiomyopathy: from cause to novel treatments. Fontana M, et al. Eur Heart J. 2026. Diagnosis and treatment of cardiac amyloidosis: a position statement of the ESC Working Group on Myocardial and Pericardial Diseases. Garcia-Pavia P, et al. Eur Heart J. 2021. This 2026 HFA Cardio Talk podcast series is supported by Bayer in the form of unrestricted financial support. The discussion has not been influenced in any way by its sponsor.

In today's episode, the discussion features Sikander Ailawadhi, MD, and Beth Faiman, CNP, PhD, who provided clinical perspectives on the ongoing development of subcutaneous isatuximab-irfc (Sarclisa) administration via an on-body injector for patients with multiple myeloma. Dr Ailawadhi is a professor of medicine, a consultant in the Division of Hematology/Oncology in the Department of Internal Medicine, and a consultant in the Department of Cancer Biology at the Mayo Clinic Comprehensive Cancer Center in Jacksonville, Florida. Dr Faiman is a nurse practitioner in the Department of Hematology/Oncology at Cleveland Clinic and a member of the Cancer Prevention, Control and Population Research Program at the Case Comprehensive Cancer Center, both in Cleveland, Ohio. 

Today's guest is Paul Cater. Paul is a veteran strength and conditioning coach with over 25 years of experience spanning professional baseball, collegiate athletics, and high-performance team environments. Paul is known for blending traditional strength training with rhythm, timing, gravity, and a deeply relational, art-driven approach to coaching. His work challenges purely formulaic or data-driven models and puts the live training session back at the center of athlete development. In an era where training is increasingly automated, optimized, and reduced to dashboards and numbers, it's easy to lose the human element that actually drives performance. This conversation explores how rhythm, feel, load, and coaching presence shape not just outputs, but adaptability, resilience, and long-term athletic growth. If you've ever felt that “something is missing” in modern training environments, this episode speaks directly to that gap. In this episode, Paul and I explore training as a live performance rather than a static program. We discuss using early isometric and axial loading as a readiness anchor, how downbeat rhythm and eccentric timing drive better outputs, and why chasing numbers too aggressively can undermine real performance. We dive into music, movement, art, and coaching intuition, and how creating alive, rhythmic sessions builds stronger athletes, and better coaches, without relying solely on rigid protocols or excessive monitoring. Today's episode is brought to you by Hammer Strength and Lila Exogen. Use the code “justfly20” for 20% off any Lila Exogen wearable resistance training, including the popular Exogen Calf Sleeves. For this offer, head to Lilateam.com Use code “justfly10” for 10% off the Vert Trainer View more podcast episodes at the podcast homepage. (https://www.just-fly-sports.com/podcast-home/) Timestamps 0:00 – Mountain Training Inspirations 6:00 – The Role of Community in Training 12:15 – Performance and the Observer Effect 23:27 – Shifting Training Protocols 32:32 – Balancing Data and Intuition 42:14 – Efficacy of Isometric Training 47:23 – Five-Minute Wonders 53:28 – The Art of Adaptation 57:44 – Embracing the Subconscious 1:28:06 – A Playlist for Performance Actionable Takeaways 0:07 – Mountain training inspirations Training in demanding natural environments reshapes how you view effort, pacing, and resilience. Use uneven terrain and elevation to naturally regulate intensity instead of forcing outputs. Let the environment create variability rather than programming it artificially. Periodically remove mirrors, clocks, and screens to reconnect athletes with internal feedback. 6:00 – The role of community in training Training outcomes improve when athletes feel socially anchored. Design sessions where athletes work together rather than in isolation. Use shared challenges to build collective buy-in and accountability. View community as a performance multiplier, not a soft add-on. 12:15 – Performance and the observer effect Athletes change behavior when they know they are being measured. Use testing sparingly to avoid distorting natural movement. Train without constant feedback to preserve authentic effort. Recognize when measurement helps clarity and when it creates tension. 23:27 – Shifting training protocols Protocols should evolve with the athlete, not remain fixed. Regularly reassess whether a method still serves the athlete's needs. Avoid loyalty to systems that no longer produce adaptation. Let context, stress, and readiness guide training decisions. 32:32 – Balancing data and intuition Numbers inform decisions, but intuition completes them. Use data as a reference point, not the final authority. Trust experienced pattern recognition when data feels incomplete. Teach younger coaches how to observe, not just measure. 42:14 – Efficacy of isometric training Isometrics offer clarity, control, and nervous system regulation. Use isometrics to teach position awareness and intent. Apply them during deloads or recovery periods. Emphasize quality of tension rather than maximal force. 47:23 – Five-minute wonders Short, focused training can still drive adaptation. Use brief sessions to maintain rhythm during busy schedules. Prioritize intent and execution over duration. Stack small doses consistently rather than chasing long sessions. 53:28 – The art of adaptation Adaptation is individual, nonlinear, and context dependent. Avoid expecting identical outcomes from identical programs. Adjust based on response, not expectation. Respect that progress can look quiet before it looks obvious. 57:44 – Embracing the subconscious Much of performance operates below conscious control. Reduce over-cueing to allow automatic movement to emerge. Trust repetition and environment to shape behavior. Coach less, observe more. 1:28:06 – A playlist for performance Music influences emotional and physical rhythm. Use music intentionally to shape session tone. Match tempo to desired movement qualities. Allow athletes some ownership over the training atmosphere. Quotes from Paul Cater “Training is as much about remembering what we are as it is about building what we want to become.” “The moment measurement changes behavior, you have to question what you are actually training.” “Community is not separate from performance. It is performance.” “Coaching is an art because people are not repeatable systems.” “Isometrics give you honesty. There's nowhere to hide.” “Data can guide you, but it cannot feel the athlete.” “Adaptation does not care about your program, only your response.” “Sometimes the best thing you can do as a coach is stop talking.” About Paul Cater Paul Cater is a veteran strength and conditioning coach with over 25 years of experience working across professional baseball, collegiate athletics, tactical populations, and high-performance team sport environments. He has served in leadership and performance roles with organizations including Major League Baseball, NCAA programs, and private high-performance facilities, and is known for his ability to blend high-intensity strength training with rhythm, coordination, and ecological skill development. Paul's coaching philosophy emphasizes gravity, timing, and rhythm as foundational drivers of athletic performance. Rather than relying solely on rigid programming or isolated testing, his sessions are built around early exposure to meaningful load, isometric and inertial work, and rhythmic constraints that reveal readiness, alignment, and intent in real time. His work integrates elements of sprint mechanics, change of direction, elastic strength, and movement artistry to create training environments that are both physically effective and psychologically engaging. Currently working in a collegiate performance setting, Paul is deeply interested in coaching as a live, relational craft; treating each session as a performance that develops not just outputs, but awareness, adaptability, and ownership in athletes. His approach bridges traditional strength training with concepts from sport, art, music, and survival movement, offering a perspective that challenges purely automated or data-driven models of performance.

Rich Gaspari needs no introduction in the bodybuilding and supplement industry. From childhood dreams inspired by Arnold in muscle magazines to setting new standards for conditioning on the Mr. Olympia stage, Rich’s journey represents decades of dedication to the sport and science of bodybuilding. After a career-ending injury forced him to transition from competing to entrepreneurship, he founded Gaspari Nutrition nearly three decades ago with a singular focus: creating effective supplements backed by proper dosing and real science. In Episode #202 of the PricePlow Podcast, Rich shares the complete arc of his entrepreneurial journey, from gym ownership and personal training to building one of the industry’s most respected brands. He discusses his science-forward nutritional philosophy that was well ahead of the curve, the devastating impact of the amino spiking scandal, going through bankruptcy, and his difficult-yet-principled decision to rebuild. We also get into why Proven Egg became the cornerstone of his comeback, where he was once again ahead of the curve. Throughout the conversation, Rich emphasizes the importance of ethics, innovation, and adapting to changing markets while staying true to quality ingredients and efficacious dosing. https://blog.priceplow.com/podcast/rich-gaspari-202 Video: Rich Gaspari Discusses Three Decades of Supplement Innovation and Ethical Business Practices https://www.youtube.com/watch?v=JNkeJCtr7MI Detailed Show Notes: Rich Gaspari on Building, Losing, and Rebuilding Gaspari Nutrition (0:00) – Introduction: A Legend Returns to PricePlow (2:30) – The Childhood Dream: From Muscle Magazines to Basement Training (6:15) – Teenage Competition and Nutritional Education (10:45) – Early Supplement Experiences and Egg Protein Discovery (14:00) – The Professor: Training with Lee Haney (18:30) – Following Barry Sears and the 40-40-20 Diet (22:45) – Career-Ending Injury and Entrepreneurial Pivot (26:15) – Founding Gaspari Nutrition: Education and Efficacy (31:00) – SuperPump 250 and the Pre-Workout Revolution (37:15) – The Dark Times: Bankruptcy (43:30) – Rebuilding from Zero: The Proven Egg Strategy (49:45) – Why Egg White Protein Matters (55:00) – Current Product Portfolio and Future Innovation (1:01:15) – Adapting to Influencer Marketing and Direct-to-Consumer (1:06:30) – Ethics, Morals, and Long-Term Thinking (1:11:45) – Business Lessons: Knowing What You Don’t Know (1:14:00) – Mike’s Endorsement and Future Plans (1:17:00) – Final Advice: Step by Step and Stay Loyal Where to Follow and Learn More Connect with Rich Gaspari and Gaspari Nutrition Rich Gaspari on LinkedIn Rich Gaspari on Instagram Gaspari Nutrition on Instagram Gaspari Nutrition Official Website Gaspari Nutrition on PricePlow – Sign up for news alerts and price comparisons Key Products Discussed … Read more on the PricePlow Blog

Show SummaryOn today's episode, we're featuring featuring a replay of a recent conversation that PsychArmor's own Carole Turner had with Jim Lindsay on the Howard's Huddle podcast. Provide FeedbackAs a dedicated member of the audience, we would like to hear from you. If you PsychArmor has helped you learn, grow, and support those who've served and those who care for them, we would appreciate hearing your story. Please follow this link to share how PsychArmor has helped you in your service journey Share PsychArmor StoriesAbout Today's GuestJoshua Parish is an Iraq War Veteran who's greatest passion is helping veterans when they transition into civilian life and giving them the best opportunity to be successful. Parish has over 15 years of experience working with local, state, and federal government agencies creating programs that have developed sustainable solutions including: Veterans Treatment Court, Transitional Housing for Homeless Veterans, Veterans Transportation Initiative, among others. Parish has been awarded the Community Leader Best of Michigan Award and a Veteran Hero Award. He holds a Juris Doctorate degree from Western Michigan Thomas Cooley School of Law. Parish is an avid golfer and enjoys spending time with his wife and children. Links Mentioned During the EpisodeVet Life WebsiteDownload the Battle Buddy AppFrom Glory Days: Veterans Edition Podcast  PsychArmor Resource of the WeekThis week's PsychArmor Resource of the Week is The PsychArmor course 15 Reasons to Hire a Military Spouse. As an employer, you are looking for untapped talent pools. One talent pool that can be overlooked is the diverse and highly educated group of military spouses. Take this course to learn the top 15 Reasons to Hire a Military Spouse. You can find the resource here: https://learn.psycharmor.org/courses/15-Reasons-to-Hire-a-Military-Spouse Episode Partner: Are you an organization that engages with or supports the military affiliated community? Would you like to partner with an engaged and dynamic audience of like-minded professionals? Reach out to Inquire about Partnership Opportunities Contact Us and Join Us on Social Media Email PsychArmorPsychArmor on XPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families.  You can find more about the work that he is doing at www.veteranmentalhealth.com  

In this episode, we're digging into a topic that underlies everything we do in functional medicine but rarely gets the airtime it deserves: somatic ways to reduce stress. We step outside the usual conversations about labs, supplements, pathophysiology, and food as medicine to talk about what it actually looks like to regulate your nervous system in real life. Because while “reduce your stress” is one of the most common recommendations in a healing protocol, very few people are ever taught how to do that in a tangible, embodied way. This is a deeply practical episode focused on helping you release stored tension and trapped stress from the body using simple somatic tools. We explore why trauma and chronic stress don't just live in your brain--they can show up as disease, pain, and symptoms in your body and can get in the way of healing. You'll walk away with approachable techniques you can start using immediately to calm your nervous system, improve resilience, and support your body's ability to heal. Also in this episode:  Episode 447: Stress Management Tools to Reset your HPA-Axis Episode: 438 Vagus Nerve  Episode 424: How Daily Walking Can Transform Your Health Episode 171: Movement as Medicine  Adaptogen Boost 18% off with code ADAPT18 Signs of a dysregulated nervous system What is somatic therapy? How breath can regulate stress responds 4-7-8 Breath How scent can support stress response Episode 455: Jodi Cohen of Vibrant Blue Oils Tracing the scent of fear: Study identifies region of brain involved in fear response - Fred Hutch Aromatherapy through the lens of trauma-informed care: Stress-reduction practices for healthcare professionals - ScienceDirect Get a bottle of the Parasympathetic Blend for just $15 + free shipping! ($38.95) 5-4-3-2-1 technique Relaxing with Touch Movement as Medicine Walking Pad C2 Link https://collabs.shop/gzeqhw Episode 322: Nature as Medicine Sound and vibration 5 Reasons to Gargle Salt Water and How to Do it Naturally Nourished Episode 394 The Human Electrical Force Functional Medicine Support for stress How To Use NutriSense CGM (Reviewing 14 Days of Data) Labrix Neurohormone Panel Heart Rate Variability Adaptogen Boost Calm and Clear  Adrenal Support GABACalm Relax and Regulate Stress Manager Bundle Anti-Anxiety Bundle This episode is sponsored by:  This episode is sponsored by Naturally Nourished Supplements providing: Purity, Potency, and Efficacy at a value you can't beat! My goal with Naturally Nourished supplements is to provide you with products that will enhance and reclaim the quality of life for you and your loved ones!    We will always price formulas 2-5% below market industry standard and competitors. On top of this we offer subscription discounts at an additional 10% off, bundled discounts at an additional 12% off, and seasonal promotions to ensure quality formulas are accessible.  Use the code PODCAST10 for 10% off your next purchase. 

 In this episode of ‘All Things Endurance Podcast,' host, Rick Prince chats with Dr. Andrew Fix, a physical therapist and orthopedic clinical specialist. Rick and Dr. Fix discuss the efficacy of recovery tools, as well as the basics of recovery and common mistakes he sees endurance athletes make. Below are the specific areas that Rick and Dr. Fix chat about during this episode:1.     Could you tell our listeners a bit more about yourself? 2.     There are near endless recovery tools available today including foam rollers, percussion guns and compression boots… to name just a few. From a macro point of view, do you think that tools have long term effects, or is the benefit more from an acute standpoint? 3.     Do you think that a lot of athletes forget about the basics of recovery (i.e., sleep, rest days, eating well, etc…) and instead focus on recovery tools? 4.     What is the science behind cold plunges and saunas, as there seems to be conflicting information about the efficacy of them. 5.     Do you think a lot of athletes try to ‘self-treat' injuries/niggles with recovery modalities versus seeing a professional such as a PT? 6.     While I'm sure that it's largely individually-based, if an athlete was going to purchase three recovery tools, are there three that you would say that provide the most value? 7.     What are the top mistakes that you see athletes make with respect to recovery? 8.     What are some recovery myths/protocols that athletes are still using today that don't have the evidence to support their utilization? 9.     Lastly, as the body functions as a systemic point of view, do you often see athletes self-treating a particular body part with a recovery modality that likely isn't the root cause of the pain/discomfort? What would your advice for these individuals?To learn more about Dr. Fix's practice, please visit:  www.physioroomco.com For $75 off a UESCA certification, use code ATE75 

Ambient documentation is becoming normal in clinics. But the most interesting “voice” capability may not be transcription at all.In the latest episode of Faces of Digital Health, Henry O'Connell (Canary Speech) explains why voice biomarkers stalled for decades: the field analyzed words, not the neurological signal behind speech production.Canary's approach focuses on the “primary data layer”—how the central nervous system drives respiration, vocal cord vibration, and articulation in real conversational speech. A few details that stood out: ⏱️ ~45 seconds of conversation can be enough for assessment

This week on the Naturally Nourished Podcast, we're digging into the newly released governmental nutrition guidelines. If you've been around here for any length of time, you know our core message has always been simple: eat real food. So imagine our surprise when these updated guidelines actually move closer to that exact philosophy, emphasizing whole foods, nutrient density, and fewer ultra-processed ingredients. It's not perfect, but it's a meaningful shift in the right direction, and one we never thought we'd see from official policy. In this episode, we break down what the guidelines got right, where they still miss the mark, and what this all means for real families navigating grocery stores, school lunches, and confusing nutrition messaging. We also revisit Ali's Optimal Eating Wheel she developed back in 2014 and compare it side-by-side with today's recommendations — and yes, she was about a decade ahead of her time. We share our top critiques from a food-as-medicine lens and unpack the potential ripple effects on schools, SNAP, and institutional food systems so you can understand how these changes may actually show up in everyday life. Also in this episode:  LIVE Food-as-Medicine Keto Reset Naturally Nourished Academy Mentorship Program starts 2/4 Naturally Nourished Episode 465 Naturally Nourished Academy Part 1 Naturally Nourished Episode 466 Naturally Nourished Academy Part 2 Naturally Nourished Episode 472 Good, Better, Best with Brenda Bennett  Our Thoughts on the New Guidelines Realfood.gov The Power of Protein Baby Led Weaning Naturally Nourished Kids use code GIVEHEALTH Naturally Nourished Food as Medicine for the Whole Family This episode is sponsored by:  This episode is sponsored by Naturally Nourished Supplements providing: Purity, Potency, and Efficacy at a value you can't beat! My goal with Naturally Nourished supplements is to provide you with products that will enhance and reclaim the quality of life for you and your loved ones!    We will always price formulas 2-5% below market industry standard and competitors. On top of this we offer subscription discounts at an additional 10% off, bundled discounts at an additional 12% off, and seasonal promotions to ensure quality formulas are accessible. Use the code PODCAST10 for 10% off your next purchase. 

Sean and Andrew are back at Purdue University with resident tar spot expert Darcy Telenko.    The crew discusses: ✅ Efficacy of fungicide application for tar spot and southern rust ✅ Taking the emotion out of management decisions ✅ Most effective fungicide application timing for a one-pass program ✅ How drones are changing fungicide applications ✅ The yield impact of tar spot disease ✅ How to predict onset of tar spot disease ✅ What research is happening now to better understand tar spot disease Meet the Guest:

Show SummaryOn today's episode, we're featuring featuring a replay of a recent conversation that PsychArmor's own Carole Turner had with Jim Lindsay on the Howard's Huddle podcast. Provide FeedbackAs a dedicated member of the audience, we would like to hear from you. If you PsychArmor has helped you learn, grow, and support those who've served and those who care for them, we would appreciate hearing your story. Please follow this link to share how PsychArmor has helped you in your service journey Share PsychArmor StoriesAbout Today's GuestHoward's Huddle Podcast is a show where untold stories find their voice and unfinished missions find their ending. During the show, Jim explores the lived experiences of veterans, military spouses, and the employers who believe in second service. The show honors the legacy of Sergeant Howard Gumm, a WWII hero who gave his life in service and was awarded the Distinguished Service Cross. Now, they're on a mission to upgrade his honor to the Medal of Honor During this conversation, Jim has a conversation with Carole Turner, Senior Advisor at PsychArmor, joins Howard's Huddle to share her journey as a military spouse, advocate, and champion for military families. With over 30 years of lived experience, a background in communications and education, and leadership in both nonprofit and volunteer roles, Carole brings powerful insight into the challenges and opportunities facing military and Veteran communities.Links Mentioned During the EpisodeHoward's Huddle Podcast on YouTubePsychArmor Resource of the WeekThis week's PsychArmor Resource of the Week is The PsychArmor course 15 Reasons to Hire a Military Spouse. As an employer, you are looking for untapped talent pools. One talent pool that can be overlooked is the diverse and highly educated group of military spouses. Take this course to learn the top 15 Reasons to Hire a Military Spouse. You can find the resource here: https://learn.psycharmor.org/courses/15-Reasons-to-Hire-a-Military-Spouse Episode Partner: Are you an organization that engages with or supports the military affiliated community? Would you like to partner with an engaged and dynamic audience of like-minded professionals? Reach out to Inquire about Partnership Opportunities Contact Us and Join Us on Social Media Email PsychArmorPsychArmor on XPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families.  You can find more about the work that he is doing at www.veteranmentalhealth.com  

"Am I really one of those who depend upon their mental prayer, their visits to the Blessed Sacrament, above all upon their Mass or their Communion, to put real moving power into their preaching? If I am not, I may perhaps be a loudly 'tinkling cymbal,' or even give forth the more pompous din of 'sounding brass,' but I am not communicating to others any love, that love which makes the eloquence of the friends of God impossible to resist." Part Four of the classic work by the French Trappist monk, Dom Jean-Baptiste Chautard (1858-1935), describes the many ways in which the interior life ensures the fruitfulness of active apostolic works. Episode 4: Part Four (sections a - d) 00:00 - Intro 00:39 - The Interior Life is the Condition on which the Fruitfulness of Active Works Depends 07:36 - a. The Interior Life Draws Down the Blessings of God 15:18 - b. It Makes the Apostle Capable of Sanctifying Others by His Example 23:51 - c. It Makes the Apostle Radiate the Supernatural: the Efficacy of This Radiation 01:13:42 - d. It Makes the Gospel Worker Truly Eloquent This work will be released in its entirety in episodic format. Links The Soul of the Apostolate full text: https://www.cmri.org/0-olmc-mission/catholic-books/soul_of_the_apostolate.pdf SUBSCRIBE to Catholic Culture Audiobooks https://podcasts.apple.com/us/podcast/catholic-culture-audiobooks/id1482214268 SIGN UP for Catholic Culture's newsletter http://www.catholicculture.org/newsletter DONATE at http://www.catholicculture.org/donate/audio Theme music: "2 Part Invention", composed by Mark Christopher Brandt, performed by Thomas Mirus. ©️2019 Heart of the Lion Publishing Co./BMI. All rights reserved.

In this episode of The Scope Forward Show, Praveen Suthrum speaks with Alex Noumidis, Co-founder and CEO of Nerva, a digital therapeutic platform for IBS (Irritable Bowel Syndrome) and other disorders of gut-brain interaction. They discuss the origins of Nerva, the science of psychophysiology, digital health adoption in GI, and the challenges of bringing behavioral therapies into mainstream gastroenterology. The conversation dives deep into the power of gut-directed hypnotherapy, its clinical validation, the bottlenecks in scaling access to GI psychology, and what it takes to build a product that patients actually use. They've seen 300,000 patients and plan to expand to all GI conditions. Recorded between Australia and Mumbai, this global conversation also reflects on the evolving landscape of GI care.*

In today's episode, we had the pleasure of speaking with Rahul Banerjee, MD, FACP, about the ongoing investigation of CELMoDs for multiple myeloma. Dr Banerjee is an assistant professor in the Clinical Research Division of Fred Hutchinson Cancer Center, as well as an assistant professor in the Division of Hematology and Oncology at the University of Washington in Seattle. In our exclusive interview, Dr Banerjee discussed the potential of CELMoDs for multiple myeloma management, highlighting their superior efficacy and safety compared with traditional immunomodulatory drugs (IMiDs) like lenalidomide (Revlimid) and pomalidomide (Pomalyst). He also noted strong preclinical and clinical data with CELMoDs, as well as their favorable safety profiles that include fewer immune and hematopoietic effects. Additionally, he explained that early data suggest that CELMoDs could replace traditional IMiDs, offering better long-term outcomes and fewer adverse effects. 

Wir können lernen, zu verzeihen. Es gibt dazu Kurse, wie zum Beispiel das Mindfulness-Based Training in Forgiveness (MBTF) und weitere Übungen im Vergebungsprozess. (Wiederholung vom 16.01.25)**********Quellen aus der Folge:Toussaint, L. L., Owen, A. D., & Cheadle, A. (2012). Forgive to live: Forgiveness, health, and longevity. Journal of Behavioral Medicine, 35, 375-386. Wade, N. G., Hoyt, W. T., Kidwell, J. E., & Worthington Jr, E. L. (2014). Efficacy of psychotherapeutic interventions to promote forgiveness: a meta-analysis. Journal of consulting and clinical psychology, 82(1), 154. Karremans, J. C., van Schie, H. T., van Dongen, I., Kappen, G., Mori, G., van As, S., ... & van der Wal, R. C. (2020). Is mindfulness associated with interpersonal forgiveness?. Emotion, 20(2), 296. **********Mehr zum Thema bei Deutschlandfunk Nova:Sorry: Warum uns aufrichtige Entschuldigungen so wichtig sindNachsicht – wie wir uns und anderen vergebenVerhalten: Warum wir uns so oft entschuldigen**********Ihr könnt uns auch auf diesen Kanälen folgen: TikTok und Instagram .**********Ihr habt Anregungen, Ideen, Themenwünsche? Dann schreibt uns gern unter achtsam@deutschlandfunknova.de

Luke Hedrick, Dave Furfaro, and recurrent RFJC guest Robert Wharton are joined again today by Nicole Ng to discuss the FIBRONEER-IPF trial investigating Nerandomilast in patients with IPF. This trial was published in NEJM in 2025 and looked at Neradomilast vs placebo for treating patients with IPF, on or off background anti-fibrotic therapy. This agents is now FDA approved for pulmonary fibrosis, and understanding the trial results is essential for any pulmonary physician treating patients with IPF or progressive pulmonary fibrosis. Article and Reference Today’s episode discusses the FIBRONEER-IPF trial published in NEJM in 2025. Richeldi L, Azuma A, Cottin V, Kreuter M, Maher TM, Martinez FJ, Oldham JM, Valenzuela C, Clerisme-Beaty E, Gordat M, Wachtlin D, Liu Y, Schlecker C, Stowasser S, Zoz DF, Wijsenbeek MS; FIBRONEER-IPF Trial Investigators. Nerandomilast in Patients with Idiopathic Pulmonary Fibrosis. N Engl J Med. 2025 Jun 12;392(22):2193-2202. doi: 10.1056/NEJMoa2414108. Epub 2025 May 18. PMID: 40387033. https://www.nejm.org/doi/abs/10.1056/NEJMoa2414108 Meet Our Guests Luke Hedrick is an Associate Editor at Pulm PEEPs and runs the Rapid Fire Journal Club Series. He is a senior PCCM fellow at Emory, and will be starting as a pulmonary attending at Duke University next year. Robert Wharton is a recurring guest on Pulm PEEPs as a part of our Rapid Fire Journal Club Series. He completed his internal medicine residency at Mt. Sinai in New York City, and is currently a pulmonary and critical care fellow at Johns Hopkins. Dr. Nicole Ng is an Assistant Profess of Medicine at Mount Sinai Hospital, and is the Associate Director of the Interstitial Lung Disease Program for the Mount Sinai National Jewish Health Respiratory Institute. Infographic Key Learning Points Why this trial mattered IPF therapies remain limited: nintedanib and pirfenidone slow (but do not stop) decline and often cause GI side effects. Nerandomilast is a newer agent (a preferential PDE4B inhibitor) with antifibrotic + immunomodulatory effects. Phase 2 data (NEJM 2022) looked very promising (suggesting near-“halt” of FVC decline), so this phase 3 trial was a big test of that signal. Trial design essentials Industry-sponsored, randomized, double-blind, placebo-controlled, large multinational study (332 sites, 36 countries). Population: IPF diagnosed via guideline-aligned criteria with central imaging review and multidisciplinary diagnostic confirmation. Intervention: nerandomilast 18 mg BID, 9 mg BID, or placebo; stratified by background antifibrotic use. Primary endpoint: change in FVC at 52 weeks, analyzed with a mixed model for repeated measures. Key secondary endpoint: time to first acute exacerbation, respiratory hospitalization, or death (composite). Who was enrolled Typical IPF trial demographics: ~80% male, mean age ~70, many former smokers. Many were already on background therapy (~45% nintedanib, ~30–33% pirfenidone). Notable exclusions included significant liver disease, advanced CKD, recent major cardiovascular events, and psychiatric risk (suicidality/severe depression), reflecting class concerns seen with other PDE4 inhibitors. Efficacy: what the primary endpoint showed Nerandomilast produced a statistically significant but modest reduction in annual FVC decline vs placebo (roughly 60–70 mL difference). Importantly, it did not halt FVC decline the way the phase 2 data suggested; patients still progressed. Important nuance: interaction with pirfenidone Patients on pirfenidone had ~50% lower nerandomilast trough levels. Clinically: 9 mg BID looked ineffective with pirfenidone, so 18 mg BID is needed if used together. In those not on background therapy or on nintedanib, 9 mg and 18 mg looked similar—suggesting the apparent “dose-response” might be partly driven by the pirfenidone drug interaction Secondary and patient-centered outcomes were neutral No demonstrated benefit in the composite outcome (exacerbation/resp hospitalization/death) or its components. Quality of life measures were neutral and declined in all groups, emphasizing that slowing FVC alone may not translate into felt improvement without a disease-reversing therapy. The discussants noted this may reflect limited power/duration for these outcomes and mentioned signals from other datasets/pooling that might suggest mortality benefit—but in this specific trial, the key secondary endpoint was not positive. Safety and tolerability Diarrhea was the main adverse event: Higher overall with the 18 mg dose, and highest when combined with nintedanib (up to ~62%). Mostly mild/manageable; discontinuation due to diarrhea was relatively uncommon (but higher in those on nintedanib). Reassuringly, there was no signal for increased depression/suicidality/vasculitis despite psychiatric exclusions and theoretical class risk. How to interpret “modest FVC benefit” clinically The group framed nerandomilast as another tool that adds incremental slowing of progression. They emphasized that comparing absolute FVC differences across trials (ASCEND/INPULSIS vs this trial) is tricky because populations and “natural history” in placebo arms have changed over time (earlier diagnosis, improved supportive care, etc.). They highlighted channeling bias: patients already on antifibrotics may be sicker (longer disease duration, lower PFTs, more oxygen), complicating subgroup comparisons. Practical takeaways for real-world use All three antifibrotics are “fair game”; choice should be shared decision-making based on goals, tolerability, dosing preferences, and logistics. Reasons they favored nerandomilast in practice: No routine lab monitoring (major convenience advantage vs traditional antifibrotics). Generally better GI tolerability than nintedanib. BID dosing (vs pirfenidone TID). Approach to combination therapy: They generally favor add-on rather than immediate combination to reduce confusion about side effects—while acknowledging it may slow reaching “maximal therapy.” Dosing guidance emphasized: Start 18 mg BID for IPF, especially if combined with pirfenidone (since dose reduction may make it ineffective). 9 mg BID may be considered if dose reduction is needed and the patient is not on pirfenidone (e.g., monotherapy or with nintedanib).

Show SummaryOn today's episode, we're featuring a conversation with Navy Spouse Patty Sandoval, Founder and CEO of HomeFront Haven, an organization that provides clinically informed community support to military spouses and partners before, during and after a deployment so that no one carries the homefront alone. Provide FeedbackAs a dedicated member of the audience, we would like to hear from you. If you PsychArmor has helped you learn, grow, and support those who've served and those who care for them, we would appreciate hearing your story. Please follow this link to share how PsychArmor has helped you in your service journey Share PsychArmor StoriesAbout Today's GuestPatricia “Patty” Sandoval, is a proud military spouse and public health professional. She built HomeFront Haven™ after experiencing mental health struggles during her husband's deployment in 2023. During that period, Patty found that there was a critical need for evidence backed care focused on supporting positive mental health outcomes among military spouses and partners. During the deployment, Patty kept hearing “You knew what you signed up for” and friends would reassure her that she'd be “ok.” Instead, Patty found herself exhausted, anxious, and feeling incredibly alone.  To ensure that others wouldn't have to experience the same journey, she sought to advance a preventative approach to mental health.HomeFront Haven™'s model prioritizes community-based support as a critical strategy to reduce reliance on crisis care systems. Instead of asking spouses and partners, “Didn't you know what you signed up for?” this program asks, “How can we support you, so you don't have to carry the home front alone?”Links Mentioned During the EpisodeHomeFront Haven Web SitePsychArmor Resource of the WeekThis week's PsychArmor Resource of the Week is The PsychArmor course Accessing Health Care. This course offers service members, Veterans, and their families an overview of the available healthcare options. You can find the resource here: https://learn.psycharmor.org/courses/Accessing-Health-Care Episode Partner: Are you an organization that engages with or supports the military affiliated community? Would you like to partner with an engaged and dynamic audience of like-minded professionals? Reach out to Inquire about Partnership Opportunities Contact Us and Join Us on Social Media Email PsychArmorPsychArmor on XPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families.  You can find more about the work that he is doing at www.veteranmentalhealth.com  

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/EBAH/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/GFF865. CME/EBAH/AAPA/IPCE credit will be available until January 4, 2027.Menin Masters for AML Care: Guidance on Integrating Menin Inhibitor Regimens & Boosting Efficacy in Challenging AML Subtypes In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and HealthTree Foundation for Acute Myeloid Leukemia. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by independent educational grants from Johnson & Johnson, Kura Oncology, Inc., and Syndax.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/EBAH/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/GFF865. CME/EBAH/AAPA/IPCE credit will be available until January 4, 2027.Menin Masters for AML Care: Guidance on Integrating Menin Inhibitor Regimens & Boosting Efficacy in Challenging AML Subtypes In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and HealthTree Foundation for Acute Myeloid Leukemia. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by independent educational grants from Johnson & Johnson, Kura Oncology, Inc., and Syndax.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/EBAH/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/GFF865. CME/EBAH/AAPA/IPCE credit will be available until January 4, 2027.Menin Masters for AML Care: Guidance on Integrating Menin Inhibitor Regimens & Boosting Efficacy in Challenging AML Subtypes In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and HealthTree Foundation for Acute Myeloid Leukemia. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by independent educational grants from Johnson & Johnson, Kura Oncology, Inc., and Syndax.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/EBAH/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/GFF865. CME/EBAH/AAPA/IPCE credit will be available until January 4, 2027.Menin Masters for AML Care: Guidance on Integrating Menin Inhibitor Regimens & Boosting Efficacy in Challenging AML Subtypes In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and HealthTree Foundation for Acute Myeloid Leukemia. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by independent educational grants from Johnson & Johnson, Kura Oncology, Inc., and Syndax.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/EBAH/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/GFF865. CME/EBAH/AAPA/IPCE credit will be available until January 4, 2027.Menin Masters for AML Care: Guidance on Integrating Menin Inhibitor Regimens & Boosting Efficacy in Challenging AML Subtypes In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and HealthTree Foundation for Acute Myeloid Leukemia. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by independent educational grants from Johnson & Johnson, Kura Oncology, Inc., and Syndax.Disclosure information is available at the beginning of the video presentation.

This content has been developed for healthcare professionals only. Patients who seek health information should consult with their physician or relevant patient advocacy groups.For the full presentation, downloadable Practice Aids, slides, and complete CME/EBAH/AAPA/IPCE information, and to apply for credit, please visit us at PeerView.com/GFF865. CME/EBAH/AAPA/IPCE credit will be available until January 4, 2027.Menin Masters for AML Care: Guidance on Integrating Menin Inhibitor Regimens & Boosting Efficacy in Challenging AML Subtypes In support of improving patient care, this activity has been planned and implemented by PVI, PeerView Institute for Medical Education, and HealthTree Foundation for Acute Myeloid Leukemia. PVI, PeerView Institute for Medical Education, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.SupportThis activity is supported by independent educational grants from Johnson & Johnson, Kura Oncology, Inc., and Syndax.Disclosure information is available at the beginning of the video presentation.

Nase zu, Geldbeutel auf! Bei Erkältung landet oft irgendwas aus der Apotheke im Einkaufskorb. Aber können Erkältungsmittel wie Gelomyrtol, ACC-Akut, Sinupret oder Dolo-Dobendan die Erkältung wirklich bekämpfen? Oder haben wir es hier hauptsächlich mit dem Placeboeffekt zu tun? Ein Blick in die Studienlage zeigt: Für viele Mittel ist die wissenschaftliche Evidenz überraschend dünn. Falls ihr in dieser Folge Umckaloabo, Meditonsin, Aspirin Complex und Wick MediNait vermisst – die haben wir uns in Folge #48 angeschaut: https://www.quarks.de/podcast/quarks-science-cops-folge-48-erkaeltungsmittel-wissenschaft-oder-kruemeltee/ Aus der Quarks-Redaktion empfehlen wir den Quarks-Podcast Mal Angenommen. Erste Folge: Mal angenommen, Deutschland wäre jung. Den gibt's hier: https://1.ard.de/quarks_mal_angenommen_audiothek und hier: https://1.ard.de/quarks_mal_angenommen_spotify Hier sind unsere wichtigsten Quellen für diese Folge (alle findet ihr auf https://www.quarks.de/podcast/erkaeltungsmittel-2-quarks-science-cops): Cardot, J.-M. et al.: Validated correlation of mass loss and drug release [...] cetylpyridinium chloride (CPC) and benzocaine (1.4 mg/10 mg) lozenges […] (Journal of Drug Delivery Science and Technology, 2022) https://www.sciencedirect.com/science/article/pii/S177322472200733X Jund, R. et al. Clinical efficacy of a dry extract of five herbal drugs in acute viral rhinosinusitis (Rhinology, 2012) https://www.rhinologyjournal.com/Rhinology_issues/1120.pdf S3-Leitlinie der DEGAM für Halsschmerzen von 2020 (aktuellste Fassung, wird aktuell überarbeitet) https://register.awmf.org/assets/guidelines/053-010l-S3_Halsschmerzen_2021-12-abgelaufen.pdf Jund, R. et al.: Herbal drug BNO 1016 is safe and effective in the treatment of acute viral rhinosinusitis. (Acta Oto-Laryngologica, 2014) https://pubmed.ncbi.nlm.nih.gov/25496178/ Gillissen, A. et al.: A Multi-centre, Randomised, Double-blind, Placebo-controlled Clinical Trial on the Efficacy and Tolerability of GeloMyrtol® forte in Acute Bronchitis (Drug Research, 2013) https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0032-1331182 S3-Leitlinie DEGAM Akuter und chronischer Husten 2021 https://register.awmf.org/assets/guidelines/053-013l_S3_akuter-und-chronischer-Husten_2025-11.pdf Sheffner, A. L.: The Reduction in vitro in viscosity of mucoprotein solutions by a new mucolytic agent, N-Acetyl-Cysteine (Annals oft he New York Academy of Sciences, 1963) https://nyaspubs.onlinelibrary.wiley.com/doi/epdf/10.1111/j.1749-6632.1963.tb16647.x Video- und Ton-Ausschnitte, die in dieser Episode verwendet wurden: Werbespot GeloMyrtol® forte https://www.youtube.com/watch?v=HABJPkjpQVk Werbespot ACC https://www.youtube.com/watch?v=5IYpoJc1MCk Werbespot ACC Akut mit Iris Berben https://www.youtube.com/watch?v=DYow3EZLIDQ Werbespot Dolo Dobendan https://www.facebook.com/DobendanDeutschland/videos/1945925302566218 Werbespot Sinupret eXtract https://www.youtube.com/watch?v=UYyKfa2rx2w Donald Trump speech from 2024 election night https://www.youtube.com/watch?v=vPOdsmGXUAM Von Maximilian Doeckel und Jonathan Focke.

In this episode of the Award-winning PRS Journal Club Podcast, 2026 Resident Ambassadors to the PRS Editorial Board – Lucas Harrison, Christopher Kalmar, and Priyanka Naidu- and special guest, Shai Rozen, MD, discuss the following articles from the January 2026 issue: "The Efficacy of Flap Debulking after Facial Reanimation Surgery to Enhance Facial Symmetry" by Weiss, Fricke, Hohenstein, et al. Read the article for FREE: https://bit.ly/FlapDebulk Special guest, Shai Rozen is Professor and Vice-Chairman in the Department of Plastic Surgery at the University of Texas Southwestern Medical Center and Director of the Facial Reanimation Program, specializing in treating patients with facial paralysis. He completed both general surgery and plastic surgery training at Johns Hopkins, followed by fellowships in both craniofacial and peripheral nerve surgery.  READ the articles discussed in this podcast as well as free related content: https://bit.ly/JCJan26Collection The views expressed by hosts and guests are their own and do not necessarily reflect the official policies or positions of ASPS.

Happy new year and welcome to a new season of JHLT: The Podcast! In this year-end recap, the Digital Media Editors will each share one of their favorite studies from The Journal of Heart and Lung Transplantation in 2025. You'll get a look at some of the best science in advanced heart and lung failure from the past year.   Studies featured: Efficacy and safety of sotatercept across ranges of cardiac index in patients with pulmonary arterial hypertension: A pooled analysis of PULSAR and STELLAR Gomberg-Maitland M, et al. JHLT Apr 2025 44(4):609 – 624. A consensus-based framework for the psychosocial evaluation of pediatric candidates for cardiothoracic transplant and ventricular assist devices Lefkowitz DS, et al. JHLT Apr 2025 44(4):487-502. ABO-incompatible heart transplants in children aged 2-9 years: A new paradigm in transplant? Hollis P, et al. JHLT Dec 2025 44(12):1910-1917. Heart transplantation in Ukraine during wartime: A retrospective cohort study of standard vs marginal donor heart transplantation outcomes Todurov B, et al. JHLT Nov 2025 44(11):1728-1734.   For the latest studies from JHLT, visit www.jhltonline.org/current, or, if you're an ISHLT member, access your Journal membership at www.ishlt.org/jhlt.   Don't already get the Journal and want to read along? Join the International Society of Heart and Lung Transplantation at www.ishlt.org for a free subscription, or subscribe today at www.jhltonline.org.

This episode reviews recent evidence on microwave and radiofrequency ablation as minimally invasive treatments for primary and secondary hyperparathyroidism, highlighting efficacy, safety, and complication profiles compared with surgery. Focusing on a multicenter prospective Radiology study in older patients, the discussion shows that both ablation techniques achieve meaningful biochemical improvement with acceptable risk, particularly as alternatives for patients who may not be ideal surgical candidates. Efficacy and Safety of Microwave and Radiofrequency Ablationin the Treatment of Hyperparathyroidism in Older Individuals:A Multicenter Prospective Study. Zhang and Liu et al. Radiology 2025; 317(1):e243359. 

Show SummaryOn today's episode, we're featuring a conversation with Michael Bailey, Deputy Director of Leadership Programs for the George W. Bush Institute. We talk about some of the initiatives of the Bush Institute, including the Veteran Leadership Program, the Democracy is a Verb initiative and the Bush Institute's efforts to celebrate America 250.Provide FeedbackAs a dedicated member of the audience, we would like to hear from you. If you PsychArmor has helped you learn, grow, and support those who've served and those who care for them, we would appreciate hearing your story. Please follow this link to share how PsychArmor has helped you in your service journey Share PsychArmor StoriesAbout Today's GuestMichael Bailey serves as Deputy Director, Leadership Programs, for the George W. Bush Institute. In this role, he manages the Stand-To Veteran Leadership Program, which focuses on developing the leadership skills of veterans and those who serve them and their families. Bailey also supports alumni engagement efforts for the Institute's international leadership programs.Prior to joining the George W. Bush Institute, Bailey provided operations, media, and communications support to The American Choral Directors Association, a music organization dedicated to the excellence and advancement of choral music.Bailey is a native of Arlington, Texas. He received his Bachelor of Arts in Music (Voice) from The University of Oklahoma, and he holds a Master of Business Administration with concentrations in finance and real estate from Southern Methodist University Cox School of Business. He has a passion for running and enjoys racing in half and full marathons.Links Mentioned During the EpisodeGeorge W. Bush InstituteStand-To Veteran Leadership ProgramAmerica 250Democracy is a Verb initiative  PsychArmor Resource of the WeekThis week's PsychArmor Resource of the Week is The PsychArmor course The Myths and Facts of Military Leaders. This course identifies four of the most popular myths about military leaders and how they don't align with the reality of working alongside Veterans and Service members. You can find the resource here:  https://learn.psycharmor.org/courses/The-Myths-and-Facts-of-Military-Leaders Episode Partner: Are you an organization that engages with or supports the military affiliated community? Would you like to partner with an engaged and dynamic audience of like-minded professionals? Reach out to Inquire about Partnership Opportunities Contact Us and Join Us on Social Media Email PsychArmorPsychArmor on XPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families.  You can find more about the work that he is doing at www.veteranmentalhealth.com  

In mid-December 2025, the FDA approved an at home devicethat aims to treat depression by sending electric current into a part of the brain (the prefrontal cortex) known to regulate mood. This has been available in the UK since 2019 but it is new to the US. The manufacturer has stated that over 55,000 patients have used the device across Europe, the UK, Switzerland, and Hong Kong. How does this work? Is there data to support this new therapy? In this episode, we will summarize three consecutive years of data (2023, 2024,2025) to answer that question. Listen in for details. 1.     Sci Amer: https://www.scientificamerican.com/article/u-s-approves-first-device-to-treat-depression-with-brain-stimulation-at-home/2.     August 12, 2023: Burkhardt, Gerrit et al.Transcranial direct current stimulation as an additional treatment to selectiveserotonin reuptake inhibitors in adults with major depressive disorder inGermany (DepressionDC): a triple-blind, randomised, sham-controlled,multicentre trial The Lancet, Volume 402, Issue 10401, 545 – 5543.     October 21, 2024: Woodham, R.D., Selvaraj, S.,Lajmi, N. et al. Home-based transcranial direct current stimulation treatmentfor major depressive disorder: a fully remote phase 2 randomizedsham-controlled trial. Nat Med 31, 87–95 (2025). https://doi.org/10.1038/s41591-024-4.     December 15, 2025: Moshfeghinia R, Bordbar S,Roointanpour Y, Arab Bafrani M, Shalbafan M. Efficacy and safety of home-basedtranscranial direct current stimulation (tDCS) on patients with depressivedisorders: a systematic review and meta-analysis of randomized clinical trials.Sci Rep. 2025 Dec 15;15(1):43850. doi: 10.1038/s41598-025-28648-5. PMID:41398008; PMCID: PMC12705823.

Send us a textTo close out 2025, we are revisiting our top podcast episodes of 2025, including this one discussing creatine and mental health with creatine researcher, Dr. Riccardo De Giorgi.We spoke with Dr. Riccardo De Giorgi about:His published study, "Efficacy and safety profile of oral creatine monohydrate in add-on to cognitive-behavioural monohydrate in depression: An 8-week pilot, double blind, randomised, placebo-controlled feasibility and exploratory, placebo-controlled feasibility and exploratory trial in an under-resourced area"Where he'd like to see additional research Dr Riccardo De Giorgi is Clinical Lecturer at the University of Oxford, Department of Psychiatry, and ST6 at Health Education England-Thames Valley, Oxford Health NHS Foundation Trust. He is interested in neuropsychopharmacology and evidence-based treatment of mental illness, especially mood disorders. He works on evidence synthesis, epidemiological, and experimental medicine studies to investigate repurposing opportunities for drugs with immuno-metabolic activity (e.g., statins, GLP1-RAs) in psychiatric disorders. Please note that this podcast is created strictly for educational purposes and should never be used for medical diagnosis or treatment.Connect w/ Dr. Riccardo De GiorgiX: https://x.com/rdegiorgi?lang=enLinkedIn: https://uk.linkedin.com/in/riccardo-de-giorgi-59437b255Oxford: https://www.psych.ox.ac.uk/team/riccardo-de-giorgiMentioned:Shop Kyla's favorite third party tested, certified safe for sport Creatine Monohydrate at 20% off MSRP: https://us.fullscript.com/welcome/kchannellMORE NR New customers save 10% off all products on our website with the code NEWPOD10 If you would like to work with our practitioners, click here: https://nutritional-revolution.com/work-with-us/ Save 50% off your 1st Trifecta Nutrition order with code NR50: https://trifectanutrition.llbyf9.net/qnNk05 Save 20% on all supplements at our trusted online source: https://us.fullscript.com/welcome/kchannell Join Nutritional Revolution's The Feed Club to get $20 off right away with an additional $20 Feed credit drop every 90 days.: https://thefeed.com/teams/nutritional-revolution If you're interested in sponsoring Nutritional Revolution Podcast, shoot us an email at nutritionalrev@gmail.com.

CardioNerds (Dr. Colin Blumenthal, Dr. Kelly Arps, and Dr. Natalie Marrero) discuss anti-arrhythmic drugs in the management of atrial fibrillation and atrial flutter with electrophysiologist Dr. Andrew Epstein. We discuss two major classes of anti-arrhythmic drugs, class IC and class III, as well as digoxin. Dr. Epstein explains their mechanisms of action, indications and specific patient populations in which they would be particularly helpful, efficacy, adverse side effects, contraindications, and key drug-drug interactions. We also elaborate on defining clinical trials and their clinical implications. Given the large burden of atrial fibrillation and atrial flutter in our patient population and the high prevalence of anti-arrhythmic drug use, this episode is sure to be applicable to many practicing physicians and trainees. Audio editing by CardioNerds academy intern, Grace Qiu.  Enjoy this Circulation 2022 Paths to Discovery article to learn about the CardioNerds story, mission, and values. CardioNerds Atrial Fibrillation PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls Anti-arrhythmic drugs should not be thought of as an alternative to ablation but, instead, should be considered an adjunct to catheter ablation.   Class IC anti-arrhythmic drugs, flecainide and propafenone, are highly efficacious for acute cardioversion and a great option for patients with infrequent episodes of AF who do not have a history of ischemic heart disease.    Class III anti-arrhythmic drugs like ibutilide, sotalol, and dofetilide, are highly effective for acute conversion; however, they require hospitalization for close monitoring during initiation and dose titration given the risk of prolonged QT.   Amiodarone should not be used as a first line agent given its toxicities, prolonged half-life, large volume of distribution, and drug-drug interactions.   Dr. Epstein notes that, “All drugs are poisons with a few beneficial side effects,” when highlighting the many adverse side effects of anti-arrhythmic drugs, particularly amiodarone, and the importance of balancing their benefit in rhythm control with their side effect profile.   Notes Notes: Notes drafted by Dr. Natalie Marrero. What are the Class IC anti-arrhythmic drugs and what indications exist for their use?   Class IC anti-arrhythmic drugs are anti-arrhythmic drugs that work by blocking sodium channels and, thereby, prolonging depolarizing.   Class IC anti-arrhythmic drugs include flecainide and propafenone.   Class IC anti-arrhythmic drugs are good agents to use in patients that have infrequent episodes of AF and do not want daily dosing as these agents can be used by patients when they feel palpitations and desire acute conversion back to sinus rhythm (“pill in the pocket” approach).    What are the adverse consequences and/or contraindications to using a class IC agent?  Class IC anti-arrhythmic agents are contraindicated in patients with a history of ischemic heart disease based on increased mortality associated with their use in these patients in the CAST trial.   Given the results of the CAST trial, providers should screen annually for ischemia via a functional stress test in patients on these drugs at risk for coronary disease.   These drugs can increase 1:1 conduction of atrial flutter and, therefore, require concomitant use of a beta blocker.   These agents are generally well-tolerated without any organ toxicities; however, they can precipitate heart failure in patients with cardiomyopathies, cause sinus node depression, and unmask genetic arrythmias such as a Brugada pattern.   What are the class III agents and what are indications for their use?   Class III agents are drugs that block the potassium channel, prolonging the QT, and include Ibutilide, Sotalol, and Dofetilide.    Class III agents can be considered in patients with or without a history of ischemic heart disease that desire effective acute chemical cardioversion and are willing to go to the hospital for close monitoring during dose initiation and titration.   Other specific circumstances in which one can use these agents, specifically Ibutilide, are in patients with recurrent atrial fibrillation and Wolf Parkinson White (due to slowed conduction via the accessory pathway).  What are the adverse consequences and/or contraindications to using a class III agent?  Ibutilide, Sotalol, and Dofetilide prolong the QT and increase the risk of torsade de pointes, which is why they require ECG monitoring in-patient during drug initiation and dose titration.    These agents are generally well-tolerated.   Sotalol should be avoided or used cautiously in patients with left ventricular dysfunction, while dofetilide can be used and has dose-response beneficial effects in patients with left ventricular dysfunction.   Both sotalol and dofetilide are renally cleared with specific creatinine clearance cutoffs (CrCl < 20 for dofetilide and CrCl

5. Symbolic Strikes: US and Jordan Target Resurgent ISIS in Syria. Following an attack on US personnel, the US and Jordan conducted airstrikes against ISIS strongholds, likely with Syrian regime consultation. Ahmed Sharawi questions the efficacy of striking desert warehouses when ISIS cells have moved into urban areas, suggesting the strikes were primarily symbolic domestic messaging. 1898 DAMASCUS

Show SummaryOn today's episode, we're featuring a conversation with Marine Corps Veteran Andy Gasper, CEO and President of Warrior Foundation Freedom Station, a nonprofit organization that has created Freedom Stations, recovery transition centers and housing facilities that provide injured Warriors with the acclimation time, guidance and resources to successfully make the transition from military service to civilian lifeProvide FeedbackAs a dedicated member of the audience, we would like to hear from you about the show. Please take a few minutes to share your thoughts about the show in this short feedback survey. By doing so, you will be entered to receive a signed copy of one of our host's three books on military and veteran mental health. About Today's GuestAndy Gasper is the President and CEO of Warrior Foundation Freedom Station, a nonprofit organization dedicated to supporting wounded, ill, and injured service members as they transition from military service to civilian life. Warrior Foundation Freedom Station provides transitional housing, peer support, mentorship, financial and career guidance, wellness services, and community connection through its Freedom Station residences in San Diego, helping medically retiring warriors prepare for long-term success.Under Andy's leadership, the foundation has expanded its mission to include a structured 18-month transitional housing program that offers wraparound support services designed to empower residents to pursue education, careers, and independent living. The program integrates peer-to-peer support, counseling, mentorship, and practical life guidance to foster meaningful community and improved quality of life for veterans navigating the challenges of recovery and civilian transition.A Marine Corps veteran himself, Andy brings both lived experience and professional commitment to his work, emphasizing the importance of community, dignity, and holistic support for America's warriors. Under his stewardship, Warrior Foundation Freedom Station has opened multiple transitional housing facilities and continues to scale its impact to serve more medically retiring service members and their families.Warrior Foundation Freedom Station supports service members and veterans who are seriously ill or injured, affected by post-traumatic stress or traumatic brain injury, undergoing therapy, or navigating medical retirement and reintegration into civilian life.Links Mentioned During the EpisodeWarrior Foundation WebsiteWarrior Foundation VideoPsychArmor Resource of the WeekThis week's PsychArmor Resource of the Week is The PsychArmor course How to Build a Successful Transition Plan. Join General Peter Chiarelli, United States Army (Ret.), in PsychArmor's course “How to Build a Successful Transition Plan” as he discusses the importance of setting realistic expectations, goal-setting, and flexibility during your transition. You can find the resource here:  https://learn.psycharmor.org/courses/How-to-Build-a-Successful-Transition-Plan Episode Partner: Are you an organization that engages with or supports the military affiliated community? Would you like to partner with an engaged and dynamic audience of like-minded professionals? Reach out to Inquire about Partnership Opportunities Contact Us and Join Us on Social Media Email PsychArmorPsychArmor on XPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families.  You can find more about the work that he is doing at www.veteranmentalhealth.com