Podcasts about Efficacy

Featuring an interview with Dr Alexander E Drilon, including the following topics: Overview of targetable biomarkers in lung cancer (0:00) Biomarker testing for genomic alterations in lung cancer (5:24) Overview of ROS1 alterations in lung cancer (13:44) Efficacy data with ROS1 inhibitors for lung cancer (17:02) Safety data with ROS1 inhibitors for lung cancer (21:15) Case: A woman in her early 50s with a history of non-small cell lung cancer (NSCLC) undergoes biomarker testing to reveal a ROS1 fusion (28:56) Case: A man in his late teens diagnosed with de novo advanced NSCLC with a ROS1 alteration achieves a dramatic response to therapy (46:16) Case: A woman in her early 60s with a history of ROS1-altered NSCLC receives several ROS1 inhibitors (50:52) NCPD information and select publications

Achtsamkeit und Depressionen – wie hängt das zusammen? Die MBCT (Mindfulness-Based Cognitive Therapy) zeigt, wie wir einen anderen Umgang mit belastenden Gedanken und Gefühlen lernen können. Mehr dazu in der aktuellen Folge von "Achtsam". **********An dieser Stelle findet ihr die Übung:35:04 - Übung**********Quellen aus der Folge:Barnhofer, T., Niemi, M., Michalak, J., Velana, M., Williams, J. M. G., Chiesa, A., ... & Harrer, M. (2026). Efficacy and moderators of mindfulness-based cognitive therapy in difficult-to-treat depression: a systematic review and individual participant data meta-analysis. Psychotherapy and Psychosomatics.Britton, W. B., Lindahl, J. R., Cooper, D. J., Canby, N. K., & Palitsky, R. (2021). Defining and measuring meditation-related adverse effects in mindfulness-based programs. Clinical psychological science, 9(6), 1185-1204.Kuyken, K., Warren, F., Taylor, R., Whalley, B., Crane, C. H., Bondolfi, G. … Dalgleish, T. (2016). Efficacy and moderators of mindfulness-based cognitive therapy (MBCT) in prevention of depressive relapse: An individual patient data meta-analysis from randomized trials. JAMA Psychiatry, 73(6), 565–574.**********Dieses Thema belastet dich?Hier findest du eine Übersicht zu Hilfsangeboten**********Dianes und Main Huongs Empfehlungen:Meibert, P., & Schellens, D. (2025). Therapie-Basics Mindfulness-Based Cognitive Therapy (MBCT): Mit Online-Material **********Mehr zum Thema bei Deutschlandfunk Nova:Apps gegen Depressionen: Digitale Unterstützung auf RezeptUnterstützung bei Depressionen: Zuhören hilft mehr als jeder RatschlagSchlaf und Depression: Was hilft gegen das Grübeln in der Nacht? **********Den Artikel zum Stück findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: TikTok und Instagram .**********Ihr habt Anregungen, Ideen, Themenwünsche? Dann schreibt uns gern unter achtsam@deutschlandfunknova.de

The most effective way to reduce visceral fat is a combination of high-intensity interval training (HIIT) and resistance training, though regular moderate-intensity cardio or aerobic exercise also helps, according to current research.In this episode of the “NASM CPT Podcast,” host Rick Richey unpacks the scientific evidence on exercise strategies for reducing visceral fat, addressing frequent confusion over whether HIIT or continuous moderate-intensity exercise is better. Citing several systematic reviews and meta-analyses, Rick explains that while some studies show no clear advantage between HIIT and steady-state cardio, many find that interval training, especially when extended beyond 12 weeks, provides superior reductions in visceral fat, particularly for individuals with overweight or obesity. He also highlights that progressive, combined training—mixing vigorous-intensity cardio with moderate or low-intensity resistance training—can further support visceral fat loss, which is particularly beneficial for at-risk groups such as older adults and postmenopausal women. Listeners will learn how to apply these research-backed exercise protocols for themselves or their clients, how to track progress, and why gradual progression is key, especially for those new to higher intensity workouts. This presentation also offers practical coaching insights on how to encourage clients to embrace challenging new routines. Chapters: 00:00 What is the most effective way to reduce visceral fat? 01:10 What is visceral fat and why does it matter for health? 02:26 How did a client respond to advice about losing visceral fat? 03:20 What exercise strategies can help reduce visceral fat? 05:22 Does high-intensity interval training work better than continuous cardio for visceral fat? 06:52 What does the research say about HIIT versus moderate-intensity exercise? 08:29 Are long-duration HIIT sessions more effective for fat loss? 09:18 Does exercise help reduce visceral fat in teens and young adults? 10:26 How does exercise dose relate to visceral fat loss? 12:29 Does combining resistance and aerobic training give better results for visceral fat? 13:56 How can trainers help hesitant clients start higher intensity workouts? 15:54 What extra benefits come with high-intensity training compared to moderate exercise? 16:41 Should you choose HIIT, resistance training, or regular cardio to help most people reduce visceral fat? Show References:Kramer, A. M., Martins, J. B., de Oliveira, P. C., Lehnen, A. M., & Waclawovsky, G. (2023). High-intensity interval training is not superior to continuous aerobic training in reducing body fat: A systematic review and meta-analysis of randomized clinical trials. Journal of exercise science and fitness, 21(4), 385–394. https://doi.org/10.1016/j.jesf.2023.09.002  Poon, E. T., Li, H. Y., Little, J. P., Wong, S. H., & Ho, R. S. (2024). Efficacy of Interval Training in Improving Body Composition and Adiposity in Apparently Healthy Adults: An Umbrella Review with Meta-Analysis. Sports medicine (Auckland, N.Z.), 54(11), 2817–2840. https://doi.org/10.1007/s40279-024-02070-9 Wang, R., Zhang, X., Ren, H., Zhou, H., Yuan, Y., Chai, Y., & Hou, X. (2022). Effects of different exercise types on visceral fat in young individuals with obesity aged 6-24 years old: A systematic review and meta-analysis. Frontiers in physiology, 13, 987804. https://doi.org/10.3389/fphys.2022.987804  Chang, Y., Wang, L., Wang, H., & Zhan, E. (2026). Unveiling the perfect workout: exercise modalities and dosages to combat visceral adipose tissue in individuals with overweight and obesity - a systematic review with pairwise, network, and dose-response meta-analyses. Nutrition & metabolism, 23(1), 75. https://doi.org/10.1186/s12986-026-01129-w  Lin, X., Li, G., Xie, J., & Wang, S. (2026). Effects of concurrent training on fat mass and its distribution in individuals with overweight or obesity: a systematic review, meta-analysis, and exploratory regression analysis. BMC public health, 26(1), 1403. https://doi.org/10.1186/s12889-026-26869-5 If you like what you just consumed, leave us a 5-star review, and share this episode with a friend to help grow our NASM health and wellness community! The content shared in this podcast is solely for educational and entertainment purposes. It is not intended to be a substitute for professional advice, diagnosis, or treatment. Always seek out the guidance of your healthcare provider or other qualified professional. Any opinions expressed by guests and hosts are their own and do not necessarily reflect the views of NASM. Introducing NASM One, the membership for trainers and coaches. For just $35/mo., get unlimited access to over 300 continuing education courses, 50% off additional certifications and specializations, EDGE Trainer Pro all-in-one coaching app to grow your business, unlimited exam attempts and select waived fees. Stay on top of your game and ahead of the curve as a fitness professional with NASM One. Click here to learn more. https://bit.ly/4ddsgrm

Show SummaryOn today's episode, we're having a conversation with Elizabeth Musselman, an Elizabeth Dole Caregiver Fellow, about the unrecognized evolution of veteran caregiving and the hidden burdens placed on military children.Provide FeedbackAs a dedicated member of the audience, we would like to hear from you. If you PsychArmor has helped you learn, grow, and support those who've served and those who care for them, we would appreciate hearing your story. Please follow this link to share how PsychArmor has helped you in your service journey Share PsychArmor StoriesAbout Today's GuestElizabeth Musselman is a military caregiver and a 2026 Elizabeth Dole Foundation Caregiver Fellow. In this role, she works with policymakers, Special Operations families, and veteran-serving organizations on the mental health needs of children living in veteran caregiver homes, a population largely absent from current policy and program design. Her advocacy focuses on the intergenerational effects of combat injury, including how a veteran parent's symptoms shape a child's development, attachment, and role in the family. She is a member of the Hidden Helpers Coalition and delivered the keynote address at the 2025 Elizabeth Dole Foundation National Convening in Washington, D.C. Elizabeth previously built a career in finance and technology and earned her J.D. before becoming the full-time caregiver for her husband, a retired U.S. Army Special Forces veteran, and raising their three children in the home his service shaped. Links Mentioned in this Episode Elizabeth Dole Foundation WebsiteMCON Health SummitElizabeth on LinkedInPsychArmor Resource of the WeekThis week's resource of the week is the PsychArmor course, Supporting Youth Who Support Veterans. Caregiving youth often make sacrifices to provide care for family members who are ill, injured, elderly, or disabled. This course acknowledges the contributions of these youth caregivers, goes into the scope of the problem, and offers some solutions.You can find the resource here:  https://learn.psycharmor.org/courses/supporting-youth-who-support-veterans Episode Partner: Are you an organization that engages with or supports the military affiliated community? Would you like to partner with an engaged and dynamic audience of like-minded professionals? Reach out to Inquire about Partnership Opportunities Contact Us and Join Us on Social Media Email PsychArmorPsychArmor on TwitterPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families.  You can find more about the work that he is doing at www.veteranmentalhealth.com  

Tu zona 2 no es un desastre, es tu punto de partida. En este episodio repasamos los problemas reales que os pasan en las tiradas suaves (el pulso disparado, el reloj que no cuadra, el calor, el grupo que acelera) y los ponemos a prueba con una revisión científica de 2025 que cuestiona si la zona 2 es realmente la intensidad mágica que nos han vendido. Estudio citado:Storoschuk KL, Moran-MacDonald A, Gibala MJ, Gurd BJ. "Much Ado About Zone 2: A Narrative Review Assessing the Efficacy of Zone 2 Training for Improving Mitochondrial Capacity and Cardiorespiratory Fitness in the General Population". Sports Medicine, 2025. DOI: 10.1007/s40279-025-02261-y10% de descuento en Fanté, geles, isotónicos, barritas energéticas y nutrición deportiva con ingredientes naturales y sin aromas ni añadidos innecesarios.Cupón Octubre: MBPC10 + REGALOMARCEste mes además del 10% de descuento, tenéis de regalo1 energybar pera totalmente gratis para todos los pedidos superiores a 29€.

In this episode, Lorenzo Barba speaks with Henrik Zetterberg and Gemma Salvadó about the role of biomarkers in translational neurology and monitoring therapeutic efficacy.

Breast cancer risk varies widely across patients, and surgeons play a central role in recognizing elevated risk and guiding appropriate management. In this episode, we review the spectrum of breast cancer risk and discuss practical strategies for risk assessment and risk reduction. We'll cover surveillance, lifestyle interventions, risk-reducing medications, high-risk breast lesions, and prophylactic surgery—with an emphasis on translating the available evidence into individualized clinical care.Hosts:- Rashmi Kumar, MD, PhDResident, University of Michigan General Surgery Residency ProgramTwitter/X: @RashmiJKumar- Melissa Pilewskie, MDAttending Breast Surgical Oncologist, Co-Director of the Weiser Family Center for Breast Cancer, Michigan Medicine Twitter/X: @MPilewskie- Stephanie Downs-Canner, MDAttending Breast Surgical Oncologist & Physician-Scientist, Memorial Sloan Kettering Cancer Center, Program Director of the Breast Surgical Oncology Fellowship Training Program Twitter/X: @SDownsCannerLearning Objectives: Identify major modifiable and nonmodifiable breast cancer risk factors, including genetic predisposition, family history, breast density, high-risk lesions, prior chest radiation, and lifestyle factors. Select and interpret commonly used breast cancer risk-assessment tools—including the Gail, Tyrer-Cuzick, and BCSC models—while recognizing their important limitations. Recommend appropriate risk-management strategies based on a patient's risk level, including enhanced surveillance, lifestyle interventions, genetic evaluation, and endocrine risk-reducing therapy. Explain the indications, benefits, limitations, and tradeoffs of managing high-risk breast lesions and pursuing risk-reducing surgery, including bilateral mastectomy and salpingo-oophorectomy. References:Risk-Assessment Tools National Cancer Institute. Breast Cancer Risk Assessment Tool.https://bcrisktool.cancer.gov/ National Breast Cancer Foundation. What is the Tyrer-Cuzick model?https://www.nationalbreastcancer.org/blog/tyrer-cuzick-model/ Breast Cancer Surveillance Consortium. BCSC Breast Cancer Risk Calculator.https://tools.bcsc-scc.ucdavis.edu/BC5yearRisk/#/ Chemoprevention GuidelineBevers TB, Ward JH, Arun BK, et al. Breast cancer risk reduction, version 2.2015. J Natl Compr Canc Netw. 2015;13(8):880-915. doi:10.6004/jnccn.2015.0105CDC Overview of Risk FactorsCenters for Disease Control and Prevention. Breast cancer risk factors. https://www.cdc.gov/breast-cancer/risk-factors/index.html Emerging Techniques in Risk Assessment Breastcancer.org. Polygenic risk score may help predict invasive breast cancer risk. https://www.breastcancer.org/news/polygenic-risk-score-invasive-cancer-risk Breast Cancer Research Foundation. Clairity Breast: The first FDA-authorized AI platform to predict breast cancer risk from a mammogram. https://www.bcrf.org/blog/clairity-breast-ai-artificial-intelligence-mammogram-approved/ Risk reduction Pilewskie ML, Dimick JB. Bariatric Surgery for Breast Cancer Risk Reduction—Benefit May Not Be One Size Fits All. JAMA Surg. 2023;158(6):641–642. doi:10.1001/jamasurg.2023.0534 https://pubmed.ncbi.nlm.nih.gov/37043229/ Boraka Ö, Klintman M, Rosendahl AH. Physical Activity and Long-Term Risk of Breast Cancer, Associations with Time in Life and Body Composition in the Prospective Malmö Diet and Cancer Study. Cancers (Basel). 2022 Apr 13;14(8):1960. doi: 10.3390/cancers14081960. PMID: 35454864; PMCID: PMC9025884. https://pubmed.ncbi.nlm.nih.gov/35454864/ Tzenios N, Tazanios ME, Chahine M. The impact of BMI on breast cancer - an updated systematic review and meta-analysis. Medicine (Baltimore). 2024 Feb 2;103(5):e36831. doi: 10.1097/MD.0000000000036831. PMID: 38306546; PMCID: PMC10843423. https://pubmed.ncbi.nlm.nih.gov/38306546/ Hartmann LC, Schaid DJ, Woods JE, et al. Efficacy of bilateral prophylactic mastectomy in women with a family history of breast cancer. New England Journal of Medicine 1999; 340(2):77-84. https://pubmed.ncbi.nlm.nih.gov/9887158/ Domchek SM, Friebel TM, Singer CF, et al. Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality. JAMA 2010; 304(9):967–975. https://pubmed.ncbi.nlm.nih.gov/20810374/ Rebbeck TR, Friebel T, Lynch HT, et al. Bilateral prophylactic mastectomy reduces breast cancer risk in BRCA1 and BRCA2 mutation carriers: The PROSE Study Group. Journal of Clinical Oncology 2004; 22(6):1055-1062. https://pubmed.ncbi.nlm.nih.gov/14981104/ Matteo Lazzeroni et al. Randomized Placebo Controlled Trial of Low-Dose Tamoxifen to Prevent Recurrence in Breast Noninvasive Neoplasia: A 10-Year Follow-Up of TAM-01 Study. J Clin Oncol 41, 3116-3121(2023). Elizabeth S. McDonald et al. GLP-1 Agonists Are Associated With a Significant Reduction in Breast Cancer Incidence in Women. JCO Oncol Pract 22, 1341-1348(2026). Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.  If you liked this episode, check out our recent episodes here: https://behindtheknife.org/listenBehind the Knife Premium: https://behindtheknife.org/premiumOral Board Review: https://behindtheknife.org/oral-boardOral Board Simulator: https://behindtheknife.org/oral-board/simulatorGeneral Surgery Oral Board Review Course: https://behindtheknife.org/premium/general-surgery-oral-board-reviewTrauma Surgery Video Atlas: https://behindtheknife.org/premium/trauma-surgery-video-atlasDominate Surgery: A High-Yield Guide to Your Surgery Clerkship: https://behindtheknife.org/premium/dominate-surgery-a-high-yield-guide-to-your-surgery-clerkshipDominate Surgery for APPs: A High-Yield Guide to Your Surgery Rotation: https://behindtheknife.org/premium/dominate-surgery-for-apps-a-high-yield-guide-to-your-surgery-rotationVascular Surgery Oral Board Review Course: https://behindtheknife.org/premium/vascular-surgery-oral-board-reviewColorectal Surgery Oral Board Review Course: https://behindtheknife.org/premium/colorectal-surgery-oral-board-reviewSurgical Oncology Oral Board Review Course: https://behindtheknife.org/premium/surgical-oncology-oral-board-reviewCardiothoracic Oral Board Review Course: https://behindtheknife.org/premium/cardiothoracic-surgery-oral-board-reviewOBGYN Oral Board Review Course: https://behindtheknife.org/course/obgyn-oral-board-reviewSurgical Critical Care Review: https://behindtheknife.org/premium/surgical-critical-care-reviewEPA Playbook: https://behindtheknife.org/course/epa-playbookSurgical Instrument Flashcards: https://behindtheknife.org/course/surgical-instrument-flashcardsABSITE Review: https://behindtheknife.org/course/absite-2026-exam-reviewDownload our App:Apple App Store: https://apps.apple.com/us/app/behind-the-knife/id1672420049Android/Google Play: https://play.google.com/store/apps/details?id=com.btk.app&hl=en_US

AI is rapidly changing how top leaders communicate with employees, customers, boards, and each other. In episode 2 of a special four-part series on how AI is changing leadership, we explore how executives can use AI to improve communication without outsourcing the thinking, judgment, and empathy that make it effective. Stanford professor Matt Abrahams and Zapier CEO Wade Foster discuss how leaders are using AI to synthesize information, structure ideas, prepare for difficult conversations, and rehearse for high-stakes moments. They also explain why leaders should be wary of letting AI write everything for them, how overreliance on AI can create a “comprehension gap,” and why preserving a distinctive human voice may become even more important as AI-generated communication becomes ubiquitous. Abrahams is the author of Think Faster, Talk Smarter and host of the podcast Think Fast, Talk Smart. Foster is the cofounder and CEO of Zapier, a software automation company.

Show SummaryOn today's episode, we're having a conversation with Brandy Dykhuizen and Joe Hudak, founders of Living Proof Stories, exploring how structured storytelling helps Veterans process lived experiences, build civilian connections, and move from raw isolation to processed post-military growth.Episode Partner:Are you an organization that engages with or supports the military affiliated community? Would you like to partner with an engaged and dynamic audience of like-minded professionals? Reach out to Inquire about Partnership Opportunities Provide FeedbackAs a dedicated member of the audience, we would like to hear from you. If you PsychArmor has helped you learn, grow, and support those who've served and those who care for them, we would appreciate hearing your story. Please follow this link to share how PsychArmor has helped you in your service journey Share PsychArmor StoriesAbout Today's GuestBrandy Dykhuizen is a San Diego-based writer, narrative artist, producer, and mentor who uses storytelling to bridge social divides and spark genuine, human-to-human connection. Over the past decade, she has designed, produced, and led storytelling programs, writing workshops, and live performance events for a wide range of organizations, spanning Veteran services to local arts and culture initiatives across San Diego County.As the co-founder of Living Proof Stories, Brandy works alongside community members, Veterans, military families, and emerging writers to help them shape their lived experiences into clear, impactful narratives. Rooted in the belief that personal storytelling is a vital component of mental wellness, community integration, and social cohesion, her work focuses on helping individuals find their voice, process complex personal journeys, and share their stories in ways that foster deep empathy and authentic connection.Joe Hudak is a retired Special Forces Veteran, storyteller, mentor, and therapist dedicated to helping others navigate adversity and transform their experiences into meaningful stories. He teaches storytelling as a performance art, coaching and mentoring amateur writers while producing monthly live storytelling shows that bring personal narratives to life.In retirement, Joe leads the mentor program for the San Diego Superior Court's Veteran Treatment Court, where he coordinates approximately 30 volunteer mentors and personally mentors three to four Veterans participating in the program. His commitment to service extends beyond the courtroom: for the past four years, Joe has worked as a therapist at a psychedelic-assisted therapy clinic in Mexico.Passionate about ameliorating human suffering, Joe focuses much of his work on Veterans and first responders, while also supporting people dealing with trauma and addiction. Across all his endeavors, Joe believes in the power of connection, compassion, and storytelling to foster healing and growth.Links Mentioned During the EpisodeLiving Proof Stories WebsiteLiving Proof Stories on InstagramPsychArmor Resource of the WeekThis week's PsychArmor Resource of the Week is the PsychArmor course Connecting with the Veteran In Your Life. This course provides information to help caregivers understand and address a lack of connection with the Veteran in their life. The new course incorporates a strengths-based approach to connections between a caregiver and a Veteran.You can find the resource here: https://learn.psycharmor.org/courses/connecting-with-the-veteran-in-your-lifeContact Us and Join Us on Social Media Email PsychArmorPsychArmor on XPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat Veteran, and clinical mental health counselor for service members, Veterans, and their families.  You can find more about the work that he is doing at www.veteranmentalhealth.com  

In this episode, we review three medical myths, highlighted in the "Things We Do For No Reason" series of the Journal of Hospital Medicine, including anaerobic coverage for aspiration pneumonia, fluid restriction in heart failure, and docusate for constipation. Key Concepts In aspiration pneumonia, addition of anaerobic coverage is not necessary unless a patient has necrotizing pneumonia, empyema, or lung abscess. Antibiotic selection should be aligned with CAP or HAP guidelines even if aspiration is suspected or observed. Docusate has not been shown to be more effective than placebo. Evidence-based and effective laxatives, such as PEG 3350 or psyllium, should be used instead. Patients with heart failure should not be fluid restricted unless they have hyponatremia. Excessive fluid should be treated with diuretics and optimization of guideline-directed medical therapy. References PubMed search for "Things We Do For No Reason" https://pubmed.ncbi.nlm.nih.gov/?term=%22Things+We+Do+for+No+Reason%22%5Btitle%3A%7E0%5D&sort=date Vedamurthy A, Rajendran I, Manian F. Things We Do for No Reason™: Routine Coverage of Anaerobes in Aspiration Pneumonia. J Hosp Med. 2020;15(12):754-756. doi:10.12788/jhm.3506 Caton JB, Jimenez S, Wang SX. Things We Do for No Reason™: Fluid Restriction for the Management of Acute Decompensated Heart Failure in Patients With Reduced Ejection Fraction. J Hosp Med. 2021;16(12):754-756. doi:10.12788/jhm.3639 Herrmann JJ, Brunner-La Rocca HP, Baltussen LEHJM, et al. Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial. Nat Med. 2025;31(6):2062-2068. doi:10.1038/s41591-025-03628-4 Fakheri RJ, Volpicelli FM. Things We Do for No Reason: Prescribing Docusate for Constipation in Hospitalized Adults. J Hosp Med. 2019;14(2):110-113. doi:10.12788/jhm.3124 Rao SSC, Brenner DM. Efficacy and Safety of Over-the-Counter Therapies for Chronic Constipation: An Updated Systematic Review. Am J Gastroenterol. 2021;116(6):1156-1181. doi:10.14309/ajg.0000000000001222 Dioctyl Sulfosuccinate or Docusate (Calcium or Sodium) for the Prevention or Management of Constipation: A Review of the Clinical Effectiveness. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; June 26, 2014.

In this solo episode of The Reformed Brotherhood, Tony Arsenal opens with a personal update on Jesse's wife Jen, who is recovering from a major surgery and facing ongoing complications. Rather than a typical episode, Tony turns this moment of real pastoral weight into an opportunity to explore James 5:10–18 — a passage about suffering, patience, and the mysterious power of intercessory prayer. Drawing on the examples of the Old Testament prophets, Job, and Elijah, Tony argues that suffering and God's mercy are not in tension but are deeply intertwined throughout Scripture. He also addresses the cessationist convictions he and Jesse hold while affirming the continuing call to bring the sick before the elders of the church in prayer. This episode is brief, earnest, and pastorally rich. Key Takeaways Suffering and divine mercy are not opposed — James holds them together deliberately, using Job as the paradigm case of patience that ultimately reveals God's compassion. The Old Testament prophets model faithful patience — Most prophets never saw visible fruit from their ministry, yet they continued to preach and trust, making them exemplars for suffering believers today. Intercessory prayer is a command, not merely a comfort — When suffering, James does not point believers to self-help or circumstantial remedies first; the primary command is to pray. The prayer of a righteous person has real efficacy — Without attributing change or passibility to God, Tony affirms that prayer moves God to act in a manner consistent with classical theism and biblical revelation. Elijah's humanity is the point, not his exceptionalism — James deliberately identifies Elijah as a man "with a nature like ours," anchoring the power of prayer in God rather than in the pray-er's personal greatness. Cessationism and the call to elder-led prayer coexist — The sign gifts have ceased, but the practice of calling elders to pray over the sick remains a living, binding ordinance for the church. Caregiver suffering is real and deserves intercession — Tony broadens the application beyond physical illness to recognize the spiritual and emotional weight borne by those who care for the sick. Explanatory Paragraphs Suffering and Divine Mercy Are Not in Tension One of the most counterintuitive moves in James 5 is the juxtaposition of Job's suffering with the declaration that "the Lord is compassionate and merciful." For most readers, Job's story feels like the last place you would look for evidence of divine mercy — it is a story of devastating, layered loss. But James insists that the very narrative of Job, with all of its pain, is where the mercy and purpose of God are most clearly displayed. Tony highlights this as "counterintuitive but really quite beautiful." The suffering does not negate the mercy; it is, in some mysterious sense, the vessel through which mercy is revealed. This is not stoic resignation — it is a theologically grounded confidence that God's purposes are always working toward the good of His people, even when circumstances seem to contradict that. The Efficacy of Prayer and Classical Theism Perhaps the most theologically careful section of the episode is Tony's treatment of what it means for prayer to "move" God without compromising classical theistic commitments to divine immutability and impassibility. Tony is careful here: he affirms that God does not change, does not undergo emotional mutation, and is not subject to creaturely pressure. And yet, he insists — with the Bible — that prayer does something. He describes this as God acting in "accommodated, creaturely language," a concession to our finite understanding of an infinite God who, in His sovereign wisdom, has ordained prayer as a genuine means through which He accomplishes His will. This is not open theism or Arminian concession; it is a mature Reformed affirmation that God's decrees include the prayers of His people as real instruments of His providential governance. Elijah as Everyman The closing appeal to Elijah is rhetorically powerful precisely because James refuses to let Elijah remain on a pedestal. The instinct of the reader is to think, of course Elijah's prayers worked — he was Elijah. But James dismantles that escape route immediately: "a man with a nature like ours." The miracles associated with Elijah — the drought, the rain, Mount Carmel — were not the product of Elijah's superhuman spiritual constitution. They were the product of a God who moves when His people pray. This democratizes intercessory prayer in the most profound way. The ordinary believer who kneels beside a sick friend's hospital bed is operating in the same spiritual economy as Elijah on Mount Carmel. The power belongs to God; the call to pray belongs to all of us. Memorable Quotes There's something about the prayer of God's people that in an accommodated, analogous way, an anthropomorphic way — there's something about the prayers of God's people that moves Him to act on their behalf. We hold those to be true, but we also see that the Bible reveals a God who moves when His people pray. The prayer of a righteous person has great power as it is working. But that power is not coming from the righteous person — because even Elijah, even as amazing as Elijah was, he was a man with a nature like ours. Full Transcript [00:00:47] Welcome to this special episode of The Reformed Brotherhood. I'm Tony, and tonight this is the podcast that's just me. Hey, brothers and sisters. It's just Tony tonight. [00:01:00] Um, you'll hear in a little bit why that is, but, uh, just wanted to come this week and do a real quick episode. We're gonna dive into, uh, James chapter five. [00:01:10] We're gonna talk a little bit about some suffering, some patience, and what the prayer of faith does. And rather than do an affirmation or denial tonight, uh, as you know, Jesse is not on the show tonight, uh, but I wanted to give you a quick update.  [00:01:25] Update on Jen [00:01:25] Tony Arsenal: Uh, several episodes ago, maybe, I don't know, 10 episodes ago, Jesse's wife Jen, uh, must have been longer than that actually. [00:01:32] Jesse's wife Jen, uh, joined the podcast, uh, to share a little bit about what's going on in her life and some medical challenges she's been having. And as you all know, uh, Jen had a, a rather extensive surgery, it was about 11 hours, back in May, and her recovery has been, uh, challenging to say the least. Um, so the reason Jesse's not with us tonight is Jen has had a s- a little bit of a setback. [00:01:58] Um, she's okay. [00:02:00] Jesse and, uh, Jen gave me permission to give this little update. Uh, I won't go into too many details, but, uh, Jesse's, um, Jen has had some ongoing, uh, complications with some infection and just some other general challenges that have made recovery a lot slower than we'd hoped. So I know that Jesse, uh, appreciates your prayers. [00:02:21] Jen appreciates your prayers.  [00:02:22] Pause and Pray [00:02:22] Tony Arsenal: So before we, um, before we go on to the podcast tonight, if you would take a few minutes, pause this, say a quick prayer for, uh, Jen, that her recovery would be governed and supervised by God, that the doctors would have wisdom. Uh, and say a quick prayer for Jesse. Uh, caregiver stress is a real thing, and Jesse is, uh, doing a lot to try to support Jen and make sure that she has what she needs. [00:02:47] Uh, and even in the midst of that, he has typically got more than enough energy to, uh, even compensate for me when I'm too tired to do a podcast. That's why you guys get solo episodes with him. Uh, but tonight he just needed an extra little bit of a dose of [00:03:00] rest, and I thought that we would take this opportunity to, to pray for him. [00:03:03] So go ahead and hit pause, say a quick prayer, and then join me back up here in a second.  [00:03:08] Reading James 5 [00:03:08] Tony Arsenal: So as I said, we're gonna jump into James chapter 5. Uh, this is a, a passage that I know is near and dear to Jesse's heart. Uh, he's shared a little bit about this passage on the show before, and kind of that it's been a, sort of a boon to his soul. [00:03:23] So I'm gonna start reading... Uh, I'm gonna make a connection here that I don't know is always made with this passage. So I'm gonna start reading here in verse 10. Uh, normally we would wanna start a little bit before that, and, and of course, the whole letter is an ongoing sustained argument, so it's not like you can just chunk one part out. [00:03:41] But because of the way our English translations are sometimes, uh, divided up, we tend to separate verses 10 through 12 from what follows, and I hope as we chat for just a little while tonight, it'll be a short episode, I hope we'll understand why these two are actually, uh, quite connected. So James chapter 5, [00:04:00] starting in verse 10. [00:04:01] "As an example of suffering and patience, brothers, take the prophets who spoke in the name of the Lord. Behold, we consider those blessed who remain steadfast. You have heard of the steadfastness of Job, and you have seen the purpose of the Lord, how the Lord is compassionate and merciful. And above all, my brothers, do not swear either by heaven or by earth or by any other oath, or let... [00:04:24] but let your yes be yes and your no be no, so that you may not fall into condemnation. Is any one of you suffering? Let him pray. Is anyone cheerful? Let him sing praise. Is anyone among you sick? Let him call for the elders of the church and let them pray over him, anointing him with oil in the name of the Lord. [00:04:44] And the prayer of faith will save the one who is sick, and the Lord will raise him up. And if he has committed sins, he will be forgiven. Therefore, confess your sins to one another and pray for one another, that you may be healed. The prayer of a righteous person has great power in [00:05:00] its working. Elijah was a man like us, with a nature like ours, and he prayed fervently that it might not rain. [00:05:07] And for three years and six months it did not rain on the earth. Then he prayed again, and the heaven gave rain, and the earth bore its fruit. My brothers, if anyone among you wanders from the truth and someone brings him back, let him know that whoever brings a sinner from his wandering will save his soul from death and will cover a multitude of sins." [00:05:28] So we're gonna zero in here right on verse 10, and kinda how it connects with, uh, what follows here.  [00:05:36] Prophets and Patience [00:05:36] Tony Arsenal: So this passage as a whole, starting in the beginning of verse, uh, verse five, sorta brings... Or chapter five, brings us into sort of an eschatological framework. James is talking about the sort of final judgment against the proud rich who are persecuting the church and who are, uh, sort of offending the Lord by, um, persecuting His people. [00:05:58] And so in verse seven [00:06:00] now James turns to encourage the, um, the believer not to, um, not to despair because the coming of the Lord seems slow. It's very similar to what Peter does when he, he talks about how, um, God does not will that any of His people perish, but He's seemingly delaying His coming so that all may come to repentance. [00:06:23] James is doing something very similar here, and so it's in that context that we get to verse 10. He's... In verse seven he's commanding them, or he's encouraging them to be patient, and in verse 10, he gives this example of patience and suffering. And the, the example is, uh, broadly speaking, is the prophets who spoke in the name of the Lord. [00:06:46] If you think about most of the prophets in the Old Testament, their message was not widely received. Probably the most outwardly successful prophet in the Old Testament was Jonah, uh, and he didn't even wanna be [00:07:00]successful. Um, but most of the prophets, uh, thinking particularly of, like, Jeremiah, uh, who, you know, throughout, even in his own recorded books, uh, was, uh, persecuted and ostracized. [00:07:13] People tried to kill him. Uh, we think of Isaiah who, you know, church history tells us he was sawn in two. Um, and most of the prophets did not see, uh, uh, any sort of real revival during their ministry. But they patiently continued to preach and come to the Lord and trust that what they were prophesying was, was worth it, that it was going to have its effect. [00:07:37] Job and Mercy [00:07:37] Tony Arsenal: So he, uh, he then turns kinda to the ultimate, uh, example of patience. Uh, and, and we would think... We don't necessarily always think of Job as a prophet, but there's definitely prophetic elements there- And it says, "You've heard of the steadfastness of Job." And of course, we know that Job, uh, had everything taken away from him. [00:07:58] So he, he lived this life where he [00:08:00] was immensely successful. He had a, a large family. He had lots of wealth. He had servants. Uh, religiously, he seemed to be on track. He seemed to have the Lord's favor. He certainly had the Lord's attention. Um, and it was all taken away from him. This is the part that I think is really, uh, counterintuitive but really quite beautiful, is he says, "You've heard of the steadfastness of Job, and you've seen the purpose of the Lord, how the Lord is compassionate and merciful." [00:08:29] And we've commented many times on the show that this sort of juxtaposition between, uh, sort of temporal woes or temporal trials and the Lord's mercy and compassion, how they're interrelated in scripture in a way that doesn't really feel intuitive to us. And so we're gonna skip down a little bit here. [00:08:51] He talks about, um, not swearing oaths, talks about letting your yes be yes, you know, we know. That's obviously connected to this, but we're, we're gonna just pass by that a little [00:09:00] bit.  [00:09:00] Suffering and Prayer [00:09:00] Tony Arsenal: 'Cause back in verse 13 now, he returns to this subject of suffering. He says, "Is any among you suffering? Let him pray." So there's this call for those of us who are suffering, and if we're being honest, most of us are suffering in one form or another. [00:09:17] Uh, we either have some sort of illness, or we're struggling with finances, or maybe we have some kind of depression or some other life circumstance that is making things challenging. And it says... Doesn't say, "Let him seek out the newest self-help trend." Doesn't say, "Let him, uh, let him fixate on the, the most current, up-to-date medical things." [00:09:40] It doesn't say, "Let him, uh, pursue Financial Peace University." Now, that's not to say those things are not good and important, but the command here is to let him pray. So when we face suffering, we should recognize that that suffering and the patience that comes with it is connected [00:10:00] to the mercy and the compassion of the Lord. [00:10:02] This is probably the main point and theme of James' whole letter. So you go back to verse-- or chapter one, I think it's verse 24, right? It says, um- Let it be counted all joy when you face trials of many different kinds, right? So James' whole purpose in this letter is to speak to those suffering, uh, persecuted Jewish Christians that have been scattered out into the, uh, Judean wilderness and the, the countryside, who had been scattered out into the, you know, into the country and were being preyed upon probably by wealthy Jewish landowners. [00:10:39] And the whole point of this letter is to encourage them and for them to recognize that the suffering that they're undergoing, whether there's a natural suffering, a natural evil, which obviously would be something like sickness or some sort of natural tragedy, what, what the old insurance language calls like an act of God, which is literally an act of God, something like a, like a storm that [00:11:00] ruins your crop or an earthquake that destroys your home, or m- or moral evil, which is what the, the, um, those Christians in James' audience were, were suffering under, was moral evil. [00:11:12] Says, "If any of you are suffering, let him pray." Well, how could we ever think about praying in the midst of suffering if we did not recognize, as James says, that this suffering is related to the mercy and the compassion of the Lord? That, uh, when we think of the steadfastness of Job, we see the mercy and the compassion of the Lord. [00:11:40] And then it goes on to say, "Is anyone cheerful? Let him sing praises." Well, what did, what did James command in the beginning of his book or what did he, he say? "Count it all joy when you face suffering of any kind." And so now we have, "Are you suffering?" Well, then you, you count it joy. "Well, are you [00:12:00] cheerful? [00:12:00] Elders and Healing [00:12:00] Tony Arsenal: Let you sing praise." And that brings us now to verse fourteen: "Is any among you sick?" Well, what do we do or what should we do when we're sick, when we're suffering, when we recognize that that suffering is to... unto our salvation, it's unto our sanctification? Well, we're cheerful and we praise, and we come and we join the church. [00:12:20] We come and call for the elders. We have them pray over us. They anoint us in the name of the Lord. And the prayer of faith, verse fifteen, the prayer of faith will save the one who is sick. Now, we know that, um, God moves in all sorts of ways Uh, Jesse and I are both committed cessationists, convicted cessationists. [00:12:43] We don't believe that the sign gifts, that, that the miracles that marked the, the Revelation period of the New Testament and the Old Testament, we don't believe that those sign gifts continue. But what we do know is that the Lord, through his servant [00:13:00] James, commands his people to seek out the elders of the church when they're sick and for them to pray over them. [00:13:06] And I know that Jen, uh, and Jesse have really, really great elders. They've got great support at their church. I know that there are people praying for both of them. Um, and, and this podcast is not a church, and our listeners are not the elders of the church, although some of our listeners are elders, but they're not elders... [00:13:22] I don't think there's any of them at Jesse's church.  [00:13:24] Powerful Prayer Explained [00:13:24] Tony Arsenal: Um, but there is a principle here in this passage that I think is important for us as we, as we lift Jesse and Jen up in prayer, as we think about others in our life who need prayer, who need support, who are sick, who are suffering, is that the prayer, and this is where it comes in, uh, at towards the end here, the prayer of a righteous person, verse 16, "The prayer of a righteous person has great power in its working." [00:13:49] There's something about prayer, and I don't fully understand it, this is something w- I will spend the rest of my life trying to understand. There's something about the prayer of God's [00:14:00] people that in a, an accommodated, analogous way, an anthropomorphic way, there's something about the prayers of God's people that moves him to act on their behalf. [00:14:12] And of course, you know, you go back, you listen to all of our episodes on divine simplicity and aseity and divine immutability. We're, we're classical theists. We don't think that God changes. But the, what the Bible teaches us, what it reveals to us in accommodated, creaturely language is that when the elders of the church specifically, and then God's people generally, when we pray, God moves. [00:14:39] And so that's what I'll leave you with tonight. Um, again, this, this may seem melodramatic or severe. Um, Jen's doing okay. She's, she's sick, and she's recovering. Um, m- but, but it's important for us to pray. So whether it's for Jesse and Jen, and I hope that it is, I hope that you take some more time after this episode to pray [00:15:00] for them and to pray for her specifically. [00:15:02] But I think we all have people in our lives that we know who are suffering, who are sick, who need the prayers, the powerful prayers of righteous persons to move the heart of God to orient himself to their restoration and to their glory, whether that's restoration from a physical illness in the context here of this passage, and in some senses, it's restoration from spiritual sickness. [00:15:26] Elijah Like Us [00:15:26] Tony Arsenal: Um, and he closes, and this is the most encouraging part. We think of Elijah as sort of the supreme prophet of the Old Testament Uh, that title might be arguable, uh, to go to, uh, Moses, um, although Moses tends to fall in a different category. But we think of Elijah as this man, this miracle worker, right? We think of Mount Carmel, we think of the other miracles that are associated with Elijah. [00:15:53] Uh, a- and the Bible here makes the point, James makes the point that Elijah was a man with a nature [00:16:00] like ours, and he prayed fervently that it might not rain for three years and six months, and it did not rain. And so what we see here, and this is what I'll close with, James is reminding us that the power, right, the prayer of a righteous person has great power as it is working. [00:16:18] But that power is not coming from the righteous person, 'cause even Elijah, even as amazing as Elijah was, he was a man with a nature like ours. So when we look to God, we see that, that He is the one that moves in prayer, but somehow mysteriously, somehow in His special, uh, special wisdom and special guide- counsel, somehow when we prayer- pray, that does something. [00:16:46] And again, we have to, we have to hold everything else that we understand to be true about God's immutability, His impassibility, His simplicity, all of those things. We hold those to be true, but we also see that the Bible reveals a God who [00:17:00] moves when His people pray.  [00:17:01] Final Prayer and Sendoff [00:17:01] Tony Arsenal: So we can trust that if we seek God and we pray agreeably to His will, that He will comfort and encourage and heal His people, and He will bring them back and restore them. [00:17:13] So that is my prayer and my hope for you tonight, that you would spend some time thinking about the people in your life that could benefit from you taking time to pray for them. Definitely pray for Jesse and for Jen as they're r- as she's recovering and as Jesse is supporting and caring for her. Um, it's a big burden, and he's, he's bearing it her- heroically, but, uh, he, he could use your prayer just as much, uh, as the rest of us. [00:17:39] So I will leave you with that, brothers and sisters, and until next time, honor everyone, love the brotherhood. [00:18:00]

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Welcome to the latest Midlife Minute. This episode unpacks ongoing research on Lp(a), explores how women's lipids change during the perimenopause-to-menopause transition, and clarifies what we can do about it. Stay tuned for more! IN THIS EPISODE, YOU WILL LEARN: How total cholesterol, LDL, and ApoB tend to rise most steeply around the final menstrual period, rather than increasing gradually with chronological aging Why women should have their Lp(a) checked both before and after menopause How oral and transdermal estradiol can affect LDL, HDL, triglycerides, and Lp(a) differently Why I recommend including ApoB when checking your lipids during the perimenopause window How your lifestyle can reduce your cardiovascular risk, even when your Lp(a) is elevated Why omega-3 fatty acids and commonly used lipid medications do not lower Lp(a) Why supplements are not replacements for statins in genuinely high-risk patients  I review the various PCSK9 inhibitors currently available, how they are administered, and their effects  How a CAC, a CT angiogram, and an AI-assisted CT angiogram can help women and their providers determine how aggressive their approach should be when Lp(a) is elevated Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia's website. Submit your questions to support@cynthiathurlow.com  Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow.  Purchase Cynthia's book, The Menopause Gut. Cynthia's Intermittent Fasting Transformation Book The Midlife Pause Supplement Line References: 1. Menopause Transition and Cardiovascular Disease Risk: Implications for Timing of Early Prevention: A Scientific Statement From the American Heart Association.Circulation. 2020. El Khoudary SR, Aggarwal B, Beckie TM, et al.Guideline 2. Menopause: A Cardiometabolic Transition. The Lancet. Diabetes & Endocrinology. 2022. Nappi RE, Chedraui P, Lambrinoudaki I, Simoncini T.Review 3. Dyslipidemia Across the Menopause Transition: Mechanisms, Trajectories, and Opportunities for Cardiovascular Prevention. Maturitas. 2026. Castaneda R, Tatit CP, Hurtado Andrade MD, Faubion SS, Shufelt CL.RecentReview 4. Lipoprotein(a) and Women's Cardiovascular Health: A Review. JACC. Advances. 2026. Michos ED, Saucier S, Mehran R, Koschinsky ML. 5. Lipid Metabolism in Women: A Review. Atherosclerosis. 2025. van Oortmerssen JAE, Mulder JWCM, Kavousi M, Roeters van Lennep JE.Review 6. Are Changes in Cardiovascular Disease Risk Factors in Midlife Women Due to Chronological Aging or to the Menopausal Transition?. Journal of the American College of Cardiology. 2009. Matthews KA, Crawford SL, Chae CU, et al.Observational 7. Trajectories of Lipids Around the Menopause Transition in Chinese Women: Results of the Kailuan Cohort Study. Fertility and Sterility. 2023. Dai Q, Wu S, Cao Z, et al. 8. Lipid Management in Patients With Endocrine Disorders: An Endocrine Society Clinical Practice Guideline. The Journal of Clinical Endocrinology and Metabolism. 2020. Newman CB, Blaha MJ, Boord JB, et al.Guideline 9. The Effects of Menopause Hormone Therapy on Lipid Profile in Postmenopausal Women: A Systematic Review and Meta-Analysis. Frontiers in Pharmacology. 2022. Nie G, Yang X, Wang Y, et al.SR 10. Perspectives on Dyslipidemia and Coronary Heart Disease in Women. Journal of the American College of Cardiology. 2005. Bittner V.Review 11. Dyslipidemia in Midlife Women: Approach and Considerations During the Menopausal Transition. Maturitas. 2022. Torosyan N, Visrodia P, Torbati T, Minissian MB, Shufelt CL.Review 12. Effects of gender, age and menopausal status on serum apolipoprotein concentrations.13.Lipoprotein(a).The Journal of the American Medical Association. 2025. Mora S, Kronenberg     14. Why, how and in whom should we measure levels of lipoprotein(a): A review of the latest evidence and clinical implications. Diabetes, Obesity & Metabolism. 2025. Razavi AC, Bhatia HS, Blumenthal RS, Shapiro MD, Mehta A.RecentReview 15. Red Yeast Rice for Hypercholesterolemia: JACC Focus Seminar. Journal of the American College of Cardiology. 2021. Cicero AFG, Fogacci F, Zambon A.Review 16. Overall and Sex-Specific Effect of Berberine for the Treatment of Dyslipidemia in Adults: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials. Drugs. 2023. Blais JE, Huang X, Zhao JV.SR 17. Non-Genetic Influences on Lipoprotein(a) Concentrations. Atherosclerosis. 2022. Enkhmaa B, Berglund L.Review 18. NHLBI Working Group Recommendations to Reduce Lipoprotein(a)-Mediated Risk of Cardiovascular Disease and Aortic Stenosis. Journal of the American College of Cardiology. 2018. Tsimikas S, Fazio S, Ferdinand KC, et al.Review 19. Consumption of a defined, plant‐based diet reduces lipoprotein(a), inflammation, and other atherogenic lipoproteins and particles within 4 weeks. Clinical Cardiology. 2018. Najjar RS, Moore CE, Montgomery BD. 20. Lipoprotein(a): Current Evidence for a Physiologic Role and the Effects of Nutraceutical Strategies. Clinical Therapeutics. 2019. Santos HO, Kones R, Rumana U, et al.Review 21. Effect of Lipid-Lowering Therapies on Lipoprotein(a) Levels: A Comprehensive Meta-Analysis of Randomized Controlled Trials. Atherosclerosis. 2025. Xie S, Galimberti F, Olmastroni E, et al.Recent 22. Effect of Omega-3 Fatty Acid Supplementation on the Postprandial Metabolism of Apolipoprotein(a) in Familial Hypercholesterolemia. Journal of Atherosclerosis and Thrombosis. 2023. Ying Q, Croyal M, Chan DC, et al.RCT 23.Lipoprotein(a) and Cardiovascular Disease. Lancet. 2024. Nordestgaard BG, Langsted A.Review 24. Lipoprotein(a): A Genetically Determined, Causal, and Prevalent Risk Factor for Atherosclerotic Cardiovascular Disease: A Scientific Statement From the American Heart Association. Arteriosclerosis, Thrombosis, and Vascular Biology. 2022. Reyes-Soffer G, Ginsberg HN, Berglund L, et al.Guideline 25.Clinical Trial Design for Lipoprotein(a)-Lowering Therapies: JACC Focus Seminar 2/3.Journal of the American College of Cardiology. 2023. Malick WA, Goonewardena SN, Koenig W, Rosenson RS.Review 26.2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American Collegeof Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2026. Writing Committee Members, Blumenthal RS, Morris PB, et al.Guideline 27. Noninvasive Coronary Atherosclerotic Plaque Imaging. JACC. Cardiovascular Imaging. 2023. Kwiecinski J, Tzolos E, Williams MC, et al.Review 28. Computed Tomography Angiography Versus Agatston Score for Diagnosis of Coronary Artery Disease in Patients With Stable Chest Pain: Individual Patient Data Meta-Analysis of the International COME-CCT Consortium. European Radiology. 2022. Wieske V, Walther M, Dubourg B, et al.SR 29. Association of Coronary Artery Calcium Score With Qualitatively and Quantitatively Assessed Adverse Plaque on Coronary CT Angiography in the SCOT-HEART Trial. European Heart Journal. Cardiovascular Imaging. 2022. Osborne-Grinter M, Kwiecinski J, Doris M, et al.Clinical Trial 30. AI-Guided Quantitative Plaque Staging Predicts Long-Term Cardiovascular Outcomes in Patients at Risk for Atherosclerotic CVD. JACC. Cardiovascular Imaging. 2024. Nurmohamed NS, Bom MJ, Jukema RA, et al.Observational 31. The Lancet Commission on Rethinking Coronary Artery Disease: Moving From Ischemia to Atheroma. Lancet. 2025. Zaman S, Wasfy JH, Kapil V, et al.Review 32. Efficacy and safety of novel lipoprotein(a)‐targeted therapies: A systematic review and meta‐analysis of randomized controlled trials. Diabetes, Obesity & Metabolism. 2026. Santana AUL, Yusufzai MO, Freitas APS, et al. Recent Opinion

In this episode of Psychiatric Pharmacy Pulse, host Megan Maroney, PharmD, BCPP, FAAPP, speaks with Danielle Stutzman, PharmD, BCPP, clinical assistant professor at the University of Colorado Skaggs School of Pharmacy and assistant adjunct professor at the Child and Adolescent Mental Health Division of the Department of Psychiatry at the University of Colorado School of Medicine, and member of the American Association of Psychiatric Pharmacists Board of Directors, about where centanafadine (Simtriyo; Otsuka Pharmaceutical) fits into attention-deficit/hyperactivity disorder (ADHD) pharmacotherapy. Centanafadine received FDA approval in July 2026 as a norepinephrine-dopamine-serotonin reuptake inhibitor (NDSRI) for ADHD in both pediatric and adult patients, with DEA scheduling still pending. Maroney and Stutzman note its mechanism is not entirely novel, drawing comparisons to tricyclic antidepressants, atomoxetine (Eli Lilly), and viloxazine (Qelbree; Supernus Pharmaceuticals, Inc). A pooled meta-analysis of 4 phase 3 trials plus a phase 2b crossover study found a Hedges' g effect size of about 0.37 for overall symptom severity versus placebo, a modest result that falls short of typical stimulant effect sizes of 0.8 to 1.0, though executive functioning outcomes on caregiver-rated scales appeared more promising.Safety data showed a nonsignificant increase in adverse effects (AEs) overall (pooled risk ratio, 1.29), with appetite suppression, nausea, and rash among the most common issues. Rash was the leading cause of study discontinuation in the youngest age group. Indirect comparisons suggested centanafadine may carry a lower risk of insomnia than methylphenidate and fewer AEs than atomoxetine and viloxazine, though lisdexamfetamine (Vyvanse; Takeda Pharmaceuticals) remained more effective. A boxed warning for suicidal ideation applies, which is consistent with other ADHD medications.Practical advantages discussed include a lack of reliance on cytochrome P450 metabolism, lower drug interaction risk than atomoxetine or viloxazine, and capsules that can be opened and sprinkled on applesauce, yogurt, or orange juice. Centanafadine did increase caffeine exposure roughly 2-fold, warranting patient counseling. Both Maroney and Stutzman positioned the drug as a potential second-line option for patients who are not candidates for stimulants or who have not tolerated or responded to first-line therapies.To provide feedback or suggest topics of discussion for Psychiatric Pharmacy Pulse, please reach out to Gillian McGovern, Editor (gmcgovern@pharmacytimes.com).REFERENCES1. Mattingly GW, Turkoglu O, Chang D, Ward C, Skubiak T, Zhang Z, Cutler AJ. 52-week open-label safety and tolerability study of centanafadine sustained release in adults with attention-deficit/hyperactivity disorder. J Clin Psychopharmacol. 2025;45(5):454-462. doi:10.1097/JCP.00000000000020202. Otsuka Pharmaceutical Development & Commercialization, Inc; Otsuka Pharmaceutical Co, Ltd. Otsuka receives FDA approval for first-in-class SIMTRIYO (centanafadine) for the treatment of attention-deficit/hyperactivity disorder. Otsuka US. July 24, 2026. Accessed September 16, 2026. https://www.otsuka-us.com/otsuka-shares-fda-review-update-for-centanafadine3. Adler LA, Adams J, Madera-McDonough J, et al. Efficacy, safety, and tolerability of centanafadine sustained-release tablets in adults with attention-deficit/hyperactivity disorder: results of 2 phase 3, randomized, double-blind, multicenter, placebo-controlled trials. J Clin Psychopharmacol. 2022;42(5):429-439. doi:10.1097/JCP.00000000000015754. Muneer MA, Naveed M, Amjad M, et al. Efficacy and safety of centanafadine in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of randomized controlled trials. Psychopharmacol Bull. 2026;56(3):47-65. https://pubmed.ncbi.nlm.nih.gov/42267239/5. Schein J, Cloutier M, Gauthier-Loiselle M, et al. Assessment of centanafadine in adults with attention-deficit/hyperactivity disorder: a matching-adjusted indirect comparison vs lisdexamfetamine dimesylate, atomoxetine hydrochloride, and viloxazine extended-release. J Manag Care Spec Pharm. 2024;30(6):528-540. doi:10.18553/jmcp.2024.30.6.5286. Stein MA. Editorial: centanafadine for adolescents with attention-deficit/hyperactivity disorder: is a broader mechanism of action better? J Am Acad Child Adolesc Psychiatry. 2026;65(6):764-765. doi:10.1016/j.jaac.2025.10.0207. Ward CL, Childress AC, Jin N, et al. Centanafadine for attention-deficit/hyperactivity disorder in adolescents: a randomized clinical trial. J Am Acad Child Adolesc Psychiatry. 2026;65(6):805-817. doi:10.1016/j.jaac.2025.06.023

What keeps us moving forward when work gets tough? In this episode, Graham and Paul explore psychological capital and the HERO framework—Hope, Efficacy, Resilience and Optimism. They unpack how these four developable strengths help individuals recover from setbacks, navigate uncertainty and keep performing, while showing leaders how to create the conditions in which their teams can thrive.  

Commonly people are talking about "peptides" to refer to a heterogeneous group of peptide medications or investigational compounds. These are increasingly promoted for injury recovery, tissue repair, performance and longevity, with BPC-157 attracting particular attention. But what evidence supports the claims made about these compounds? How should animal studies, biological mechanisms and personal anecdotes be interpreted? What is currently known about their safety? And what do recent regulatory discussions actually mean for their medical status and availability? In this episode, physician and Barbell Medicine founder Dr. Jordan Feigenbaum examines the evidence surrounding BPC-157 and other peptide medications, alongside the wider questions of risk, access and informed decision-making. Timestamps [00:13] What we want to address [04:47] Interview start [05:29] What do we mean by "peptides"? [10:32] BPC-157 evidence [16:49] Sourcing of peptides [20:19] The gray zone of pro-peptide communication [24:16] Risk sourcing vs drug effects [26:25] FDA lists and compounding [31:05] Risk tolerance and informed consent [43:02] Why did pharma abandon peptide research? [47:44] Harm reduction debate [51:48] Practical takeaways [56:20] Key Ideas segment (Premium members only) Episode Resources Go to episode page  Join the Sigma newsletter for free Subscribe to Sigma Nutrition Premium Enroll in the next cohort of our Applied Nutrition Literacy course Barbell Medicine Instagram: jordan_barbellmedicine Book: Signal: What Testosterone Levels Are Telling You About Your Health Related episode: #524: Strength & Fitness Levels for Reducing Chronic Disease Risk & Promoting Health Ageing – Jordan Feigenbaum, MD Further reading: Emerging use of BPC-157 in orthopaedic sports medicine: a systematic review. 2025. Ruenzi M, Stolte M, Veljaca M, et al. Efficacy and safety of PL 14736 (BPC 157) in patients with active ulcerative colitis. Gastroenterology. 2005. Meeting abstract; full study not published.

In part two of this series, Dr. Aaron Zelikovich and Dr. Bhaskar Roy discuss recommendations to help neurologists navigate the expanding landscape of myasthenia gravis treatments.  Show citation:  McLaren NP, Rosati M, Zhong W, et al. Comparison of the Efficacy and Safety of Myasthenia Gravis Treatments: A Bayesian Network Meta-Analysis. Neurology. 2026;107(3):e218351. doi:10.1212/WNL.0000000000218351  

Show SummaryOn today's episode, we're having a conversation with Navy Veteran and Psychiatric Physician Assistant Bill Reynolds, clinical director of the Unbroken program at The Meadows, discussing specialized trauma and addiction treatment, cultural competence, and holistic recovery support for veterans and first responders.Episode Partner:Our sponsor this week is Aetna, a trusted health care company, committed to serving Veterans, military families, and caregivers through meaningful, community-centered care. Provide FeedbackAs a dedicated member of the audience, we would like to hear from you. If you PsychArmor has helped you learn, grow, and support those who've served and those who care for them, we would appreciate hearing your story. Please follow this link to share how PsychArmor has helped you in your service journey Share PsychArmor StoriesAbout Today's GuestBill Reynolds is an experienced psychiatric provider and program leader with a 30-year U.S. Navy career and a master's degree from the University of Nebraska at Omaha. During his Navy service, Bill worked in diverse operational environments, including submarine duty, supporting the U.S. Marine Corps in combat, and serving as the medical officer for a U.S. Navy SEAL Team. He brings firsthand understanding of the challenges of military service and years of experience working with first responder communities, along with deep expertise in mental health care, addiction medicine, post-traumatic stress, and military leadership.As the founder and architect of highly regarded programs for active-duty military, veterans, and first responders, Bill combines clinical skill with operational and leadership experience in high-pressure environments. At The Meadows, he provides both clinical and strategic leadership, guiding program development and care with a focus on respect for service, cultural insight, and lasting recovery.Links Mentioned During the EpisodeThe Meadows WebsiteThe Meadows Unbroken ProgramPsychArmor Resource of the WeekThis week's PsychArmor Resource of the Week is the PsychArmor course Inner Conflict & Survivor's Guilt. In this course, Dr. Heidi Kraft describes the concept of moral injury and survivor's guilt in the military and Veteran community. You can find the resource here: https://learn.psycharmor.org/courses/inner-conflict-survivor-guilt Contact Us and Join Us on Social Media Email PsychArmorPsychArmor on XPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families.  You can find more about the work that he is doing at www.veteranmentalhealth.com  

Send us Fan MailIn this podcast I talk about the recently published STIMULATE-ICP trial. This is a UK based clinical trial in which 4 drugs were randomly allocated to patients with Long Covid. The patients were assessed for fatigue using the accredited Fatigue Assessment Scale prior to treatment, at 12 weeks of treatment, and then after treatment had been discontinued 12 weeks later. Patients were selected randomly from NHS Long Covid Clinics around the UK. They were assigned to one of the four arms of the study which were as follows: Rivaroxaban; Colchicine; Loratadine and Famotidine combination; control 'no drug' arm. All four study arms continued to receive standard specialist care from their NHS Long COVID Service. The results are presented and discussed.I am Dr Tim Robinson, formerly a GP family doctor for 30 years, retired as planned at the start of the Covid pandemic. Since then I have specialised exclusively in Long Covid, over the last 6 years. Currently I am GP clinical lead for NHS Long Covid Services in South West England - Bristol, North Somerset and South Gloucestershire. I provide medical support for Hope for the Community CIC. I have research involvement as co-investigator in a study on breathlessness in Long Covid, University of Bristol UK. I also provide online patient recovery programmes, for both Long Covid and ME/CFS.Long Covid Doctor is an educational series for Long Covid sufferers; each talk covers the many aspects of Long Covid, the symptoms, causes, treatments, management and expected outcomes.Episodes are found on:Apple PodcastsSpotifyGoogle PodcastsYouTubeTranscripts of the individual episodes are available on YouTube as well as:www.LongCovidDoctor.comEpisodes are accessed on:TwitterFacebookInstagramLinked inDisclaimer: Long Covid Doctor is an educational series. Any advice, diagnosis, treatments mentioned should only be considered after discussion with your own GP or qualified professional health provider.Link for STIMULATE-ICP paper, The Lancet Infectious Diseases journal:SWEETMAN, JENNY  and Consortium, STIMULATE-ICP (2026) Efficacy and safety of rivaroxaban, colchicine, and famotidine–loratadine with specialist supportive clinical care for fatigue in patients with post-COVID-19 condition in the UK: a multisite, open-label, randomised controlled trial. Lancet Infectious Diseases. ISSN: 1474-4457https://doi.org/10.1016/S1473-3099(26)00242-2General resources for Long Covid:NICE Covid-19 rapid guideline:https://www.nice.org.uk/guidance/ng188/chapter/5-ManagementHow to manage post viral fatigue after Covid-19:https://www.rcot.co.uk/how-manage-post-viral-fatigue-after-covid-19-0

Six training myths. Under twelve minutes. No fear-mongering, no gym-bro folklore, just what the research actually says about training your kid, or yourself, smarter.In this rapid-fire episode, Coach Julian goes through six of the most common training myths parents, athletes, and adult lifters hear all the time, and lays out exactly what the research says about each one.You'll learn:Whether lifting weights actually stunts a kid's growth (the AAP's position paper settles this one directly)Why soreness is a bad way to judge whether a workout "worked"Whether you really need to train every day to see results, and what a 2016 meta-analysis found actually drives progressWhy cardio alone leaves fat loss on the table, based on an 8-month randomized trial comparing cardio, weights, and both combinedWhat the research actually says about static stretching before a game, and why the timing matters more than the stretch itselfWhether strength training makes young athletes slower and bulkier (spoiler: the data says the opposite)If you've ever repeated one of these "facts" to your kid, your team, or yourself, this episode will change how you think about training in under fifteen minutes.This episode is for educational purposes based on current research and isn't a substitute for individualized coaching. For a program built on what the research actually says, visit trainwithpfp.com.In this episode:0:00 Cold open0:20 Myth 1: Lifting weights stunts a kid's growth1:50 Myth 2: Soreness means you had a good workout3:20 Myth 3: You need to train every day to see results4:50 Myth 4: Cardio alone is the best way to lose fat6:20 Myth 5: Static stretching before a game prevents injury7:50 Myth 6: Strength training makes young athletes slower and bulkier9:20 Wrap-up: which myth surprised you most?Sources referenced in this episode:Resistance Training for Children and Adolescents, AAP Position PaperThe Science of Sore: DOMS Explained, Stronger by ScienceHow many times per week should a muscle be trained to maximize hypertrophy? Schoenfeld & Grgic, systematic review/meta-analysis (PubMed)Strength Training Frequency research summary, PainScience.comCardio vs. Weights for Fat Loss (Willis et al. study breakdown), Precision NutritionA Systematic Review into the Efficacy of Static Stretching as Part of a Warm-Up for the Prevention of Exercise-Related Injury (PubMed)Static/dynamic stretching and injury/performance review, PMCYouth Resistance Training: mechanisms, strength gains, and speed/performance evidence, PMCYouth Strength Training: Top 5 Myths, Avery Faigenbaum, Ed.D.Mythbusting: Youth Resistance Training, ACSM

Randomness is brutal on a nervous system, and dogs are no exception. We come back from a much-needed “touch grass” break and dig into one of the most cited papers in the e-collar debate: the Schalke study on predictability and stress. People love to wave it around as proof that electronic collars are inherently harmful, but when we slow down and read what the researchers actually measured, the real takeaway is sharper and more practical: unpredictability is what drives the biggest cortisol spikes.We walk through how the study is set up with three beagle groups, what “predictable and controllable” really means, and why the random-stimulation group shows the most intense and lasting stress response. We also unpack the details that get skipped online, including that every trial is run at the highest intensity setting as a worst-case stress test, and how saliva cortisol timing and blinded measurement strengthen the findings. Heart rate gets discussed too, with a clear explanation of why movement can muddy that signal.From there, I connect the science to real training: learned helplessness, poor timing, and why a dog needs a clear way to shut stimulation off. I share what balanced e-collar conditioning looks like when it's done responsibly: foundation behaviors first, low working levels, clarity, and then accountability only after the dog understands the rules. If you want a research-based conversation that actually respects method, nuance, and animal welfare, hit play, then subscribe, share with a trainer friend, and leave a review so more owners can find it.SOURCES1. Schalke et al., "Clinical signs caused by the use of electric training collars on dogs in everyday life situations"   https://www.researchgate.net/publication/228355489_Clinical_signs_caused_by_the_use_of_electric_training_collars_on_dogs_in_everyday_life_situations2. PLOS ONE (2020), Vieira de Castro et al., "Does training method matter?"   https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.02250233. Cooper et al. (2014), "The Welfare Consequences and Efficacy of Training Pet Dogs with Remote Electronic Training Collars"   https://pmc.ncbi.nlm.nih.gov/articles/PMC4153538/4. Frontiers in Veterinary Science (2026), "Professional dog trainers' perspectives on training methods"   https://pmc.ncbi.nlm.nih.gov/articles/PMC12975608/5. Johnson and Wynne (2024), "Comparison of the Efficacy and Welfare of Different Training Methods in Stopping Chasing Behavior in Dogs"   https://pmc.ncbi.nlm.nih.gov/articles/PMC11428818/6. "Do aversive-based training methods actually compromise dog welfare? A literature review"   https://www.sciencedirect.com/science/article/abs/pii/S0168159117302095Visit us on the website here to see what we've got going on and how you can join our pack of good dogs and owners.

The Learning Leader Show with Ryan Hawk www.LearningLeader.com My new book, The Price of Becoming, is a USA Today, LA Times, Success Magazine, and Publishers Weekly bestseller! I think you'll find it useful. This is brought to you by Insight Global. If you need to hire one person, hire a team of people, or transform your business through Talent or Technical Services, Insight Global's team of 30,000 people around the world has the hustle and grit to deliver. My guest: Dr. Martin Seligman is one of the most influential psychologists alive. He's the founder of positive psychology and a professor at the University of Pennsylvania, where he directs the Positive Psychology Center. His research reshaped how we understand optimism, resilience, and human flourishing. His books, including Learned Optimism, Flourish, and The Hope Circuit, have sold millions of copies. His latest is Agency: The Psychological History of Human Progress. Key Learnings The three parts of agency. Efficacy is the belief you can hit a goal right now, and it drives whether you try. Optimism is the belief you can hit it in the future, and it drives persistence and grit. Imagination is the range of goals you can even picture, and it drives creativity. When a culture has all three, it progresses. When they fall, it stagnates. "Depression and pessimism and happiness and optimism are too important to be left to happy people." Marty calls himself a born depressive and pessimist. He founded positive psychology and still wakes at 4:00 a.m. to a voice telling him he can't do the thing in front of him. What he's built over decades is the skill of arguing back, treating that voice not as truth but as a rival whose job is to make him miserable. The techniques don't come naturally to anyone. A small number of people are born happy. Everyone else has to learn and practice the skills, which is why Marty spent much of his career testing them rather than assuming they work. How you respond to good news matters more than you think. When his wife Mandy won first prize in the biggest black and white photography contest in the world, Marty could have said "congratulations, dear, you deserve it" and moved on. Instead, he named the exact photo that won, asked her to repeat what the editor said word for word, and tied her talent back to how they teach their kids. Ryan's summary of what made it work: specificity and curiosity. Marty calls it active constructive responding, and done consistently, it increases love and commitment and cuts divorce rates. Marty's contrarian take on leadership. He thinks the whole hunt for "what great leaders do" is a wild goose chase, because the great leaders he's met all do completely different things. What good followers have in common is PERMA: positive emotion, engagement, relationships, meaning, and accomplishment. His advice is to promote the leaders who create the most PERMA, and to hold managers responsible for their people's well-being, not just their output, because well-being predicts productivity. Grit and agency. Grit, the idea made famous by his former student Angela Duckworth, feeds straight into optimism and increases how long people push through adversity. On Angela: "one of the best students I've ever had," and "it's great to be outdone." He credits her rare social intelligence, the ability to build allies instead of enemies. Predicting elections by counting optimism. With his graduate student Harold Zullow, Marty studied a century of nomination acceptance speeches and found the more optimistic candidate usually wins. In 1984, they sealed their prediction of the two nominees in an envelope at The New York Times and got it right. The $17,500 lesson. Convinced by Dukakis's optimistic acceptance speech, Marty flew to Edinburgh to place a legal bet and put his entire life savings on Dukakis at 2 to 1. Then he learned the speech was written by Ted Sorensen, and that Dukakis, in his own unscripted press conferences, was deeply pessimistic. He lost everything. The takeaway that shaped his later work: measure the unscripted moments, not the polished speeches. The 2024 call. Trump and Harris were even on optimism in their convention speeches. But across September and October, tracking how each explained bad events in press conferences, Trump got steadily more optimistic. Marty's team sealed another prediction: Trump winning and possibly by a lot. Why the fired-up CEO speech doesn't work great. After Marty published his method, both political parties asked him how to write optimistic speeches. He sent the protocol, and within a few elections everyone sounded optimistic, and it stopped predicting anything, because the optimism was shallow. People don't internalize a leader saying "we're going to crush it." Real agency shows up in the psychology of the team, and that comes from who you hire and how you train them, not from the speech. What the Army taught him. As lead consultant on the Army's Comprehensive Soldier Fitness program, Marty helped train 40,000 drill sergeants and profiled 900,000 soldiers from their first day. Three traits predicted who would later earn awards for excellent work and heroism: optimism, high positive emotion, and low negative emotion. On the other side, catastrophizers were more than twice as likely to develop PTSD at every level of combat. The hiring lesson. Hire optimists and happy people. Avoid catastrophizers. And when you can't pick your team, train the pessimists you already have in the skills of agency. "Put It In Perspective." The tool Marty uses to retrain catastrophizers. Picture the ominous "come see me at 4:00" email. Write down the worst thing that could happen, then the best thing, then the most likely thing, then a plan for that most likely case. Catastrophizers skip straight to the worst case and get paralyzed. The exercise pulls them back to what's actually probable. Marry an optimist. "If you're a pessimist, disaster is to marry another pessimist," because you'll both see the worst in every setback. The wine story makes the point about behavior change: after Mandy told him he'd wrecked a family engagement dinner by sending back a bottle, Marty realized that if she complained as much as he did, he wouldn't want to be married to her. He decided to stop. The critical thoughts never went away, but the behavior did. The gratitude testimonial. Think of someone still alive who did or said something that changed your life. Write a 300-word testimonial in three parts: what they did, what you did because of it, and where you are now as a result. Then deliver it in person and read it out loud. Marty has run this with thousands of people. The usual result is that both people cry, and a month later they test as less depressed and higher in well-being. Reading the minds of the dead. Marty's method for measuring agency across history is counting words. Agentic language like "choose," "compete," "can," and "do" versus language of constraint like "obliged" and "assigned." With Claude and ChatGPT, he can now do in one morning what used to take months: reading whole eras of writing and rating how agentic they are. St. Augustine and a thousand years of stagnation. Before Augustine, around 400 AD, Christian thinkers were highly agentic and taught that you could take part in your own salvation. Augustine's doctrine that grace comes only from God set Church teaching for close to a thousand years, and progress collapsed with it. When agency climbs again, as it does under Charlemagne around 800, progress climbs too. The pattern holds when you line it up against GDP, population, and writing about freedom. The manager's real job. "It's your job as a manager not just to keep productivity going, but to increase the well-being and agency of the people under you." Do that, and you get promoted. Fail at it and your time is up. The Champagne Question... What he'd celebrate a year from now. Marty wants psychohistory taken seriously as a real field, one that measures psychological variables, uses them to understand history, and then changes them to raise future happiness and productivity. Reflection Questions: Marty is 84, founded the field, and still wakes at 4 a.m. to a voice saying he can't do it. What does your version of that voice say, and what does it usually say it about? When it shows up, do you accept it as fact or argue back? Think about the last time someone close to you shared good news. Which quadrant were you in: active constructive, passive constructive, active destructive, or passive destructive? What did you actually say? Marty says a manager's job is to raise the well-being and agency of their people, not just their output. If your team was measured on PERMA tomorrow, what score would they give you, and where's the gap? If you liked this one with Marty, you should also listen to... Episode #703: Angela Duckworth - Why Grit Isn't Enough Time Stamps: 2:34 Angela Duckworth, grit & social intelligence 6:05 Active constructive responding: the Mandy photography story 12:13 Why leadership is heterogeneous, and the case for PERMA 14:49 How grit and agency fit together 16:09 The born pessimist who founded positive psychology 21:20 What the book is really about: founding psychohistory 22:52 Predicting elections & the $17,500 Dukakis bet 25:34 The 2024 prediction 29:17 Why the rah-rah CEO speech doesn't help much 31:07 What the U.S. Army taught him: optimism & PTSD 35:19 "Put It In Perspective," the tool for catastrophizers 38:55 Marry an optimist, and the wine-snob story 42:19 The gratitude testimonial 44:49 Reading the minds of the dead & St. Augustine 48:37 The manager's real job 49:33 What he'd celebrate a year from now 51:05 EOPC  

“What you think is not gospel.”Can arguing with yourself make you happier? Martin Seligman, positive psychology pioneer and author of Agency: The Psychological History of Human Progress, says our negative thoughts don't have to dictate how we feel. By recognizing our internal narratives and challenging them with evidence, we can change our outlook and build a greater sense of agency. In this episode of Think Fast, Talk Smart, Seligman and Matt Abrahams discuss flourishing, optimism, and the power of self-talk. They also examine why celebrating other people's successes takes more than saying “congratulations,” and how active, constructive communication can deepen our relationships.Takeaways:Your thoughts aren't facts. Negative self-talk can shape your emotions and actions, but learning to challenge those thoughts with realistic evidence can help you develop a more optimistic outlook.Celebrate success with curiosity, not just congratulations. Asking thoughtful questions about someone's good news helps them relive the experience and can deepen your relationship.Activity:Argue with yourself. Catch one negative thought you have about yourself this week and write it down as an argument rather than a fact. Then build the opposing case by listing three pieces of real evidence that challenge it.To listen to the extended Deep Thinks version of this episode, please visit FasterSmarter.io/premium.Episode Reference Links:Martin SeligmanMartin's Book: AgencyEp.179 Finding Positive in Negative Emotions: Communication, Happiness & WellbeingEp.181 Why Happiness is a Direction, Not a Destination: Communicat…  Connect:Premium Signup >>>> Think Fast Talk Smart PremiumEmail Questions & Feedback >>> hello@fastersmarter.ioEpisode Transcripts >>> Think Fast Talk Smart WebsiteNewsletter Signup + English Language Learning >>> FasterSmarter.ioThink Fast Talk Smart >>> LinkedIn, Instagram, YouTubeMatt Abrahams >>> LinkedIn Chapters:(00:00) - Introduction (01:20) - The Five Pillars of Flourishing (04:51) - Changing Your Inner Dialogue (06:22) - Challenging Negative Self-Talk (07:58) - Overcoming Imposter Syndrome (09:38) - Building a Sense of Agency (11:27) - Learning From Your Critics (13:18) - The Final Three Questions (20:17) - Conclusion ********Thank you to our sponsors.  These partnerships support the ongoing production of the podcast, allowing us to bring it to you at no cost.With Hiring Pro, you can hire with confidence, knowing you're getting the best talent for your needs. Get started by posting your job for free at linkedin.com/fastJoin our Think Fast Talk Smart Learning Community and become the communicator you want to be. 

Ultrasound-guided nerve blocks are no longer just a niche skill for fellowship-trained ultrasound specialists—they are a core component of modern multimodal pain management in the ED. Endorsed by ACEP, nerve blocks can offer rapid, targeted pain relief without relying solely on systemic opioids, making everything from rest to imaging and procedural workups significantly more comfortable for patients. Today, Dr. Carlos Mikell, UC Davis Emergency Ultrasound Faculty and nerve block expert, joins us to share why every emergency physician should adopt nerve blocks as part of their practice. We'll break down the top ED blocks, explore innovative indications like genicular nerve blocks for knee pain, and discuss essential safety protocols and how to get started – or become more comfortable – with blocks in your ED. Why Nerve Blocks Belongs in the ED Targeted Relief: Delivers effective, localized pain management as part of a multi-modal pain control approach, sparing patients some of the systemic side effects of opioids. Facilitates ED Workup: Relieves movement-related pain, making imaging, patient transport, and local procedures far easier and more comfortable for the patient. ACEP Endorsement: ACEP's policy statement formalizes ultrasound-guided nerve blocks as an essential skill for all emergency physicians—not just ultrasound fellowship graduates. Analgesia, Not Complete Anesthesia: The goal in the ED is regional analgesia (taking pain down to a manageable, functional level safely) rather than dense, surgical anesthesia. The Most Common ED Nerve Blocks According to data from the National Ultrasound Guided Nerve Block Registry: Fascia Iliaca Plane / Femoral Nerve Block (~36%): Indications: Hip fractures, mid-shaft/distal femur fractures, hip dislocations, and severe thigh trauma. Safety Profile: Highly safe; target plane is centimeters away from the main neurovascular bundle in a easily compressible site. Erector Spinae Plane (ESP) Block: Indications: Back pain, renal colic, shingles, and rib fractures. Forearm Blocks (Median, Ulnar, Radial): Indications: Distal forearm fractures, complex lacerations, and hand procedures. Serratus Anterior Plane (SAP) Block (~7%): Indications: Rib fractures, pre/post-chest tube insertion pain, and chest wall abscesses. Tip: Hydro-dissect with normal saline first to identify the fascial plane before injecting local anesthetic, and consider adding dexamethasone to extend duration. Innovative Block Spotlight: Genicular Nerve Block Target: Three of the primary sensory branches of the sciatic/femoral nerves supplying the anterior knee. Indications: Acute knee trauma/fractures, acute-on-chronic knee pain, and severe osteoarthritic flare-ups. Safety & Execution: Low-volume block (~10 mL total). Pearl: Omit the inferior-lateral genicular injection to avoid unintentional peroneal nerve block and foot drop. Streamlining Nerve Blocks in Your Department To move nerve blocks from a rare procedure to a routine clinical tool: ED Infrastructure: Build standardized EMR order sets, procedure note templates, and dedicated nerve block supply carts/kits. Departmental Support: Designate a point person to coordinate credentialing, interdisciplinary pathways (e.g., trauma, orthopedics), and physician/nurse/tech education. Hands-on Training: Utilize cadaver labs, simulation, and scanning shifts to build faculty and resident confidence. Non-Negotiable Safety Guidelines & LAST Prevention Nerve blocks are generally low-risk, but vigilance is critical to avoid complications like Local Anesthetic Systemic Toxicity (LAST) or direct nerve injury: Patient Selection: Avoid in uncommunicative patients (who cannot report paresthesias or tinnitus), areas at high risk for compartment syndrome, or pre-existing severe nerve deficits. Monitoring: Keep patients on cardiac telemetry for 30–60 minutes post-block for central or high-volume blocks (>10 mL or above the elbow/knee). Dosing Buffer: Calculate maximum weight-based local anesthetic doses every time; stay within 60–70% of the maximum dose to maintain a safety buffer. Intralipid Availability: Ensure 20% Intralipid is immediately accessible in the ED pharmacy or brought directly to the bedside. Injection Technique: Never point the needle directly at a nerve. Inject into the fascial plane, stop immediately if you encounter resistance, and perform frequent aspirations every 3–5 mL. What is your favorite ultrasound-guided nerve block? What barriers do you encounter to doing blocks in the ED? We'd love to hear form you! Connect with us on social media @empulsepodcast or connect with us on ucdavisem.com Hosts: Dr. Julia Magaña, Professor of Pediatric Emergency Medicine at UC Davis Dr. Sarah Medeiros, Professor of Pediatric Emergency Medicine at UC Davis Guest: Dr. Carlos Mikell, Assistant Professor of Emergency Medicine and Ultrasound Faculty at UC Davis Resources: ACEP Policy Satement: Ultrasound Guidelines: Emergency, Point-of-care, and Clinical Ultrasound Guidelines in Medicine, June 2016 ACEP Now: How To Build an Ultrasound-Guided Nerve Block Program By Arun Nagdev, MD; Kaitlen Howell, MD; Akash Desai, MD; David Martin, MD; and Daniel Mantuani, MD, MPH | on January 6, 2023  ACEP Sonoguide: Nerve Blocks NURVE Block Registry Brown J, Milgrim F, Driver L, et al. Efficacy and Safety of Adjunct Medications in ED Ultrasound-Guided Nerve Blocks: A National Ultrasound-Guided NeRVE (NURVE) Block Registry Study. Acad Emerg Med. 2025 Dec;32(12):1299-1308. doi: 10.1111/acem.70128. Epub 2025 Aug 27. PMID: 40873157. Goldsmith A, Driver L, Duggan NM, et al. Complication Rates After Ultrasonography-Guided Nerve Blocks Performed in the Emergency Department. JAMA Netw Open. 2024 Nov 4;7(11):e2444742. doi: 10.1001/jamanetworkopen.2024.44742. Erratum in: JAMA Netw Open. 2024 Dec 2;7(12):e2455847. doi: 10.1001/jamanetworkopen.2024.55847. PMID: 39535792; PMCID: PMC11561692. *** Thank you to the UC Davis Department of Emergency Medicine for supporting this podcast and to Orlando Magaña at OM Productions for audio production services. Disclaimer: The opinions expressed on this podcast are those of the hosts or guests and do not necessarily reflect the views of UC Davis Department of Emergency Medicine, UC Davis Health, or their parent organizations.

Full Title Name: Why do some Traditional Catholics cling to the New Church as the "visible Church"? Can a pope teach "untruth against tradition?"Lindsay Clancy mistrial: one juror stands firm, defense asks Trump for impossible pardon. Attend imperfect council in order to denounce it? Where are the Four Marks of the True Church in the New Order? Can there be salvation outside Christ's Church? Becoming a Godparent at Novus Order baptism? Valid Dominican Mass of 1300? Why not Thursday ember days? Is pride a curse? Efficacy of Saint Bridgette prayers? Raising the dead: where were their souls? Can United States be the "Great Eagle" of the Apocalypse? Hold fast to Tradition! This episode was recorded on 09/09/2026. Our Links: http://linkwcb.com/ Please consider making a monetary donation to What Catholics Believe. Father Jenkins remembers all of our benefactors in general during his daily Mass, and he also offers one Mass on the first Sunday of every month specially for all supporters of What Catholics Believe. May God bless you for your generosity! https://www.wcbohio.com/donate Subscribe to our other YouTube channels: ‪@WCBHighlights‬ ‪@WCBHolyMassLivestream‬ May God bless you all!

Matthew Lee, Jeffrey A SoRelle, Arun Everest-Dass, David E Gerber, Mitchell S von Itzstein. Predictive Biomarkers for Immune Checkpoint Inhibitor Efficacy: Challenges, Innovations, and a Pathway to Precision Medicine in the Era of Cancer Immunotherapy. Clin Chem 2026; 72(9): 926–47. https://doi.org/10.1093/clinchem/hvag062

Uncontrolled and resistant hypertension is more common than we think. In the second episode of this special three-part series, Dr. Neil Skolnik discusses management strategies, but also explores our new understanding of aldosterone and its stealth role in hypertension. This series is supported with support from AstraZeneca. Please listen to the episodes by clicking on the podcast player below or by freely subscribing to DOC Updates via Apple Podcasts, Amazon Music, Spotify, or your preferred podcast platform. Presented by: Neil Skolnik, MD, Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health Payal Kohli, MD, Harvard-educated preventive cardiologist and the Founder and Medical Director of Cherry Creek Heart​ in Aurora Colorado, Associate Adjunct Professor in Cardiology at Johns Hopkins University, and Associate Adjunct Professor in Cardiology at Duke University Selected references: 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee. Hypertension 2025; 82(10) Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. Lancet 2016;387:957 Efficacy and Safety of Baxdrostat in Uncontrolled and Resistant Hypertension. N Engl J Med 2025;393:1363-74. DOI: 10.1056/NEJMoa2507109 Primary Aldosteronism: An Endocrine Society Clinical Practice Guideline. The Journal of Clinical Endocrinology & Metabolism, 2025, 00, 1–43 https://doi.org/10.1210/clinem/dgaf284 A Randomized Trial of Intensive versus Standard Blood-Pressure Control. N Engl J Med 2015;373:2103-2116

Show SummaryOn today's episode, we're having a conversation with Marine Corps Veteran Patrick Forystek, Director of the Center for Veterans and Military-Affiliated Students at Michigan State University, discussing academic transition, peer support networks, and building comprehensive campus communities for student veterans and military families.Episode Partner:Our sponsor this week is Aetna, a trusted health care company, committed to serving Veterans, military families, and caregivers through meaningful, community-centered care. Provide FeedbackAs a dedicated member of the audience, we would like to hear from you. If you PsychArmor has helped you learn, grow, and support those who've served and those who care for them, we would appreciate hearing your story. Please follow this link to share how PsychArmor has helped you in your service journey Share PsychArmor StoriesAbout Today's GuestPatrick Forystek is a Marine Corps veteran whose journey from combat deployments to higher education leadership has been shaped by a commitment to service, resilience, and helping others succeed. He served from 2008 to 2012 with 1st Battalion, 11th Marines as an artillery cannoneer and section chief, deploying with the 13th Marine Expeditionary Unit and later to Afghanistan in support of Operation Enduring Freedom.Like many veterans, Patrick faced the challenges of transitioning from military service to civilian life and higher education. What began as a search for his own path after the Marine Corps became a calling to help other veterans navigate the same journey. After earning a Bachelor of Arts in English from the University of Michigan-Flint and a Master of Science in Management from Walsh College, he built a career focused on supporting military-connected students and creating opportunities for them to thrive. Today, Patrick serves as Director of the Center for Veterans and Military-Affiliated Students at Michigan State University, where he leads programs, partnerships, and initiatives that support more than 2,500 military-connected students. Throughout his career, he has remained motivated by a simple pay-it-forward philosophy: honoring the mentors, educators, and fellow veterans who helped him succeed by ensuring the next generation has access to the same support, guidance, and sense of community.Patrick's work and advocacy are rooted in the belief that military service does not end when the uniform comes off, but that it evolves into new opportunities to lead, serve, and make a difference in our community and in the lives of others.Links Mentioned During the EpisodeMSU Center for Veterans and Military-Affiliated Students WebsiteCVMAS on InstagramPsychArmor Resource of the WeekThis week's PsychArmor Resource of the Week is the PsychArmor course Choosing a College and Major. This course provides service members, Veterans, and their families with tools and resources to assist them in achieving their dreams of higher education You can find the resource here: https://learn.psycharmor.org/courses/Choosing-a-College-and-Major Contact Us and Join Us on Social Media Email PsychArmorPsychArmor on XPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families.  You can find more about the work that he is doing at www.veteranmentalhealth.com  

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It's Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It's Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction0:15 - The Classics1:57 - What's the News?6:04 - BerberineReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][1] Dong H, Wang N, Zhao L, Lu F. Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evid Based Complement Alternat Med. 2012;2012:591654. doi:10.1155/2012/591654[Study 985] Sebo ZL, Chakrabarty RP, Grant RA, D'Alessandro KB, Koss AR, Blum JLE, et al. Metformin inhibits mitochondrial complex I in intestinal epithelium to promote glycaemic control. Nat Metab. 2026;8:1291-1304. doi:10.1038/s42255-026-01530-y[Study 986] Koffert JP, Mikkola K, Virtanen KA, Andersson AMD, Faxius L, Hällsten K, et al. Metformin treatment significantly enhances intestinal glucose uptake in patients with type 2 diabetes: results from a randomized clinical trial. Diabetes Res Clin Pract. 2017;131:208-216. doi:10.1016/j.diabres.2017.07.015[Study 987] Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes. Metabolism. 2008;57(5):712-717. doi:10.1016/j.metabol.2008.01.013Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

In the first installment of this series, Dr. Aaron Zelikovich and Dr. Bhaskar Roy discuss how emerging treatments for myasthenia gravis compare to one another.  Show citation:  McLaren NP, Rosati M, Zhong W, et al. Comparison of the Efficacy and Safety of Myasthenia Gravis Treatments: A Bayesian Network Meta-Analysis. Neurology. 2026;107(3):e218351. doi:10.1212/WNL.0000000000218351  

Dr. Aaron Zelikovich talks with Dr. Bhaskar Roy about the latest treatments for myasthenia gravis, comparing their efficacy and safety.  Read the related article in Neurology®. Disclosures can be found at Neurology.org. 

Dr. Aaron Zelikovich talks with Dr. Bhaskar Roy about the latest treatments for myasthenia gravis, comparing their efficacy and safety.  Read the related article in Neurology®. Disclosures can be found at Neurology.org. 

Show SummaryOn today's episode, we're having a conversation with Registered Nurse, Military Spouse, and Workforce Development Advocate Tracy Steele, founder of Community Cultivator, an organization dedicated to strengthening well-being, belonging, and career stability for military spouses through community connection and professional developmentEpisode Partner:Our sponsor this week is Aetna, a trusted health care company, committed to serving Veterans, military families, and caregivers through meaningful, community-centered care. Provide FeedbackAs a dedicated member of the audience, we would like to hear from you. If you PsychArmor has helped you learn, grow, and support those who've served and those who care for them, we would appreciate hearing your story. Please follow this link to share how PsychArmor has helped you in your service journey Share PsychArmor StoriesAbout Today's GuestCommunity Cultivator was founded by Tracy Steele, SPHR, CPRW — a longtime military spouse, workforce development leader, and advocate for military spouse employment and community connection.​After more than two decades navigating military life, Tracy experienced firsthand the challenge of constantly rebuilding career momentum, professional networks, and community with every move. Through strategic volunteering, networking, and workforce development leadership, she became passionate about helping military spouses recognize their value and confidently pursue meaningful opportunities.But she realized military spouses needed more than job resources alone. They needed connection, belonging, and access to opportunities that could grow with them wherever military life led next.​So she built Community Cultivator.​What started as a vision in San Diego is growing into a nationwide movement helping military spouses build stronger careers, deeper connections, and lasting opportunities together.Links Mentioned During the EpisodeCommunity Cultivator WebsiteForeign Born Military Spouse NetworkSugar Bear Foundation WebsitePsychArmor Resource of the WeekThis week's PsychArmor Resource of the Week is the PsychArmor course 15 Reasons to Hire a Military Spouse. As an employer, you are looking for untapped talent pools. One talent pool that can be overlooked is the diverse and highly educated group of military spouses. Take this course to learn the top 15 Reasons to Hire a Military Spouse. You can find the resource here: https://learn.psycharmor.org/courses/15-Reasons-to-Hire-a-Military-Spouse Contact Us and Join Us on Social Media Email PsychArmorPsychArmor on XPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families.  You can find more about the work that he is doing at www.veteranmentalhealth.com  

So. 06.09. um 10 Uhr: Kostenloses Live-Webinar zum Thema "Wenn deine Sicherheit am anderen hängt: Wie du emotionale Abhängigkeit löst – ob Single oder in Beziehung". Jetzt deinen Platz sichern! 30 Sekunden Zusammenfassung Warum dein Gehirn Filme dreht: Negativitätsbias, Default Mode Network und ein Alarmsystem, das Ablehnung wie Lebensgefahr behandelt Warum „Hör auf zu denken" das Denken lauter macht – und was Kopfkino mit deinem Bindungsmuster zu tun hat (Schwan, Eisbär, Pinguin) Warum der Projektor nicht im Kopf steht, sondern im Körper – und warum du ihn nicht mit Argumenten ausschaltest 3 Wege aus der Forschung: Gefühle benennen, die Ausatmung verlängern, Gedanken haben, ohne sie zu glauben 4 Wege aus meiner Praxis: die dritte Stimme fragen, das Alter des Films erkennen, das Gespräch führen oder bewusst lassen – und dein Sicherheitssatz für die Nacht Du möchtest 1:1 an deinen Themen arbeiten? Dann fülle 7 Fragen aus und buche dir ein kostenfreies Erstgespräch zur HEARTset-Journey: Hier klicken! Hier gehts zum kostenfreien Videokurs "Deine erfüllte Partnerschaft startet hier": Hier klicken! Jetzt auf die Warteliste setzen für die neue Runde zum Beziehungssicher-Kurs: Hier klicken! Werde Heartset-Coach! Hier geht`s zur neuen Ausbildungsrunde: Hier klicken! Kostenfreier Bindungstypentest: Bist du Eisbär, Schwan oder Pinguin? Hier klicken! Blogartikel zur Vertiefung lesen: Gedankenkarussell stoppen: 9 Wege aus der Grübelfalle Hier klicken! Quellen: Repetitives negatives Denken / Grübeln Ehring, T. & Watkins, E. R. (2008). Repetitive negative thinking as a transdiagnostic process. International Journal of Cognitive Therapy Nolen-Hoeksema, S., Wisco, B. E. & Lyubomirsky, S. (2008). Rethinking rumination. Perspectives on Psychological Science Watkins, E. R. (2008). Constructive and unconstructive repetitive thought. Psychological Bulletin Negativitätsbias Baumeister, R. F., Bratslavsky, E., Finkenauer, C. & Vohs, K. D. (2001). Bad is stronger than good. Review of General Psychology Default Mode Network / Gedankenwandern Raichle, M. E. et al. (2001). A default mode of brain function. PNAS Killingsworth, M. A. & Gilbert, D. T. (2010). A wandering mind is an unhappy mind. Science Gedankenunterdrückung Wegner, D. M., Schneider, D. J., Carter, S. R. & White, T. L. (1987). Paradoxical effects of thought suppression. Journal of Personality and Social Psychology Bindung Mikulincer, M. & Shaver, P. R. (2016). Attachment in Adulthood: Structure, Dynamics, and Change (2. Aufl.). Guilford Press Körper / Perseverative Cognition Brosschot, J. F., Gerin, W. & Thayer, J. F. (2006). The perseverative cognition hypothesis. Journal of Psychosomatic Research Ottaviani, C. et al. (2016). Physiological concomitants of perseverative cognition: A systematic review and meta-analysis. Psychological Bulletin Weg 1 – Affect Labeling Lieberman, M. D. et al. (2007). Putting feelings into words. Psychological Science Torre, J. B. & Lieberman, M. D. (2018). Putting feelings into words: Affect labeling as implicit emotion regulation. Emotion Review Weg 2 – Atmung Zaccaro, A. et al. (2018). How breath-control can change your life: A systematic review on psycho-physiological correlates of slow breathing. Frontiers in Human Neuroscience Balban, M. Y. et al. (2023). Brief structured respiration practices enhance mood and reduce physiological arousal. Cell Reports Medicine Weg 3 – Achtsamkeit / Defusion Brewer, J. A. et al. (2011). Meditation experience is associated with differences in default mode network activity and connectivity. PNAS Kuyken, W. et al. (2016). Efficacy of mindfulness-based cognitive therapy in prevention of depressive relapse. JAMA Psychiatry Hayes, S. C., Strosahl, K. D. & Wilson, K. G. (2011). Acceptance and Commitment Therapy (2. Aufl.). Guilford Press

Many midlife women love the outdoors but struggle to balance sun exposure with protecting their skin's health and appearance. Is it possible to enjoy the sun without putting our skin or long-term wellbeing at risk? Get clear, science-based answers about sunscreen, skin aging, and what truly matters when choosing products for yourself and your family. Dermatology and sun care have seen a wave of confusing trends, myths, and marketing claims, especially around "natural" or "mineral" sunscreens. Pediatrician, inventor, and skin health expert Mark Mitchnick brings decades of hands-on experience, from creating transparent zinc oxide (the active ingredient behind most modern mineral sunscreens) to launching his own family's trusted brand. Mark's unique blend of medical knowledge and transparent product development offers the balanced, evidence-based information midlife women deserve. What you'll learn: How to gauge when sunscreen is actually necessary and when you might not need it The real differences between mineral and chemical sunscreens, plus what "broad spectrum" means for your skin's health Why ingredient labels, marketing claims, and SPF numbers can mislead even on "doctor recommended" brands The truth about sprays, powders, and various sunscreen delivery methods (including what works best for active families) How to model healthy sun habits at midlife and set the tone for your family, without fear or perfectionism Skin health in midlife goes beyond wrinkle prevention it's about maintaining confidence, minimizing unnecessary worry, and making informed choices that support both your health and your lifestyle. This conversation demystifies sunscreen so you can cut through the hype, protect your skin, and spend more time outdoors with trust and ease. getburnd.com (use code NT15 for 15% off) natalietysdal.com https://www.instagram.com/ntysdal https://www.tiktok.com/@ntysdal https://www.facebook.com/NatalieTysdal

Eric D. Whitman, MD, and Francis Paul Worden, MD, discuss the integration of immunotherapy into the cutaneous squamous cell carcinoma (CSCC) treatment paradigm and key considerations for navigating treatment selection for this patient population. The pair also highlight strategies to maximize efficacy and minimize toxicity with immunotherapy-based approaches.

Show SummaryOn today's episode, we're having a conversation with Navy Veteran Dr. Erik Won, President and Chief Medical Officer of Wave Neuroscience, an organization utilizing advanced neuroimaging and magnetic resonance therapy to help veterans recover from post-traumatic stress. DisclaimerThis podcast is for informational and educational purposes only and does not establish a doctor-patient relationship. The views and opinions expressed by the guest are entirely his own and do not reflect the views, policies, or official positions of his employer or company. Content is not intended to substitute for professional medical advice, diagnosis, or treatment.  Wave supplies MeRT to licensed clinics who provide treatment to patients. Talk to your physician to see if MeRT is right for you. Episode Partner:Our sponsor this week is Aetna, a trusted health care company, committed to serving Veterans, military families, and caregivers through meaningful, community-centered care. Provide FeedbackAs a dedicated member of the audience, we would like to hear from you. If you PsychArmor has helped you learn, grow, and support those who've served and those who care for them, we would appreciate hearing your story. Please follow this link to share how PsychArmor has helped you in your service journey Share PsychArmor StoriesAbout Today's GuestDr. Erik Won is President and Chief Medical Officer of Wave Neuroscience, Inc; a biotechnology company that has innovated breakthrough technologies called Magnetic e-Resonance Therapy (MeRT) and Synchronized Transcranial Magnetic Stimulation (sTMS). MeRT recently received FDA Breakthrough Technology designation and FDA clearance for Post-Traumatic Stress Disorders. These approaches utilize computational neuroanalytics and brain imaging to customize treatment protocols with the aim of restoring optimal neurological function.These modalities represent a form of precision-guided medicine that has been researched or is currently being used by premier institutions such as US Special Operations Command, Stanford University School of Medicine, Duke University - Human Performance Opti-Lab, University of Southern California (USC) Center for Neurorestoration, the University of California Los Angeles (UCLA) - David Geffen School of Medicine, University of Pennsylvania, Brown University, Air Force Research Laboratory, and the Texas A&M Institute for Bioscience and Technology.Erik joined Wave Neuroscience after serving as the Chief Physician and Chief Technology Officer (Health Services) for the Boeing Company. He also served as a US Navy Flight Surgeon for Marine Medium Helicopter Squadron 268, and received the distinction of serving as the ACE Flight Surgeon for the 11th Marine Expeditionary Unit, 1st Marine Expeditionary Force. Dr. Won has been published in numerous peer-reviewed journals, textbooks, and presented in numerous academic conferences. He completed his residency at the Harvard OEM combined residency program and was appointed Chief Resident. He received a Masters in Public Health (MPH) from the Harvard School of Public Health and Masters in Business Administrations (MBA) from the University of Southern California, Marshall School of BusinessLinks Mentioned During the EpisodeWave Neuroscience WebsiteBrain Treatment Center WebsitePsychArmor Resource of the WeekThis week's PsychArmor Resource of the Week is the PsychArmor course Brain Health & Wellness Learning Series – PTSD. Nearly everyone goes through a traumatic event at least once during their lifetime. Military service members and Veterans are especially vulnerable to the lasting effects of post-traumatic stress due to the nature of their duties and experiences. While this can be a difficult diagnosis to navigate, it is treatable, and social support is one of the leading factors for lasting recovery. Having someone to trust and confide in while feeling heard and validated is a vital part of the healing process. This series on post-traumatic stress disorder explores the presentation and diagnosis of PTSD, its impact on both the Veterans you support and the lives of those around them, and effective treatment modalities, so you'll be better equipped to provide meaningful support. You can find the resource here: https://learn.psycharmor.org/courses/WWP-BHW-PTSD Contact Us and Join Us on Social Media Email PsychArmorPsychArmor on XPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families.  You can find more about the work that he is doing at www.veteranmentalhealth.com  

Please visit answersincme.com/ZGK860 to participate, download slides and supporting materials, complete the post test, and get a certificate. Presented by Amer Zeidan, MBBS, MHS. In this activity, an expert in myelodysplastic syndromes (MDS) discusses approaches to optimize management of anemia in lower-risk MDS. Upon completion of this activity, participants should be better able to: Translate the latest clinical trial data to the management of patients with lower-risk MDS; Evaluate evidence-based strategies for optimizing the use of available agents in lower-risk MDS; and Design treatment plans that effectively sequence available therapies in patients with lower-risk MDS.

The recent increase in Treasury's buyback operations will remove long-term USTs from the market using new short-term debt or cash from the Treasury General Account. Secretary Bessent believes the buybacks will help bring long-term yields closer to what he deems fundamentals. The move comes weeks after Treasury officials intervened to support the yen, in part from worries that Japan would otherwise sell Treasuries to buy up its currency. In this special edition of Simply Put, we talk with Brad Setser, Senior Fellow at the Council on Foreign Relations, about what motivated the increase in Treasury's buyback operations, why the US helped strengthen the yen, and whether these interventions will have lasting impacts on the Treasury market. Simply Put: Expert perspectives on the trends influencing fixed income, banking, and the macro landscape, hosted by FHN Financial's Macro Strategist, Will Compernolle. Tune in to better understand what's moving the markets and what to keep an eye on in the weeks and months ahead. Listen and subscribe wherever you get your podcasts.

When the medication you rely on for relief starts being followed by more and more headaches, it can feel confusing and frustrating.In this episode of Migraine Heroes Podcast, host Diane Ducarme explores rebound headache, also known as medication-overuse headache, and why frequent treatment can sometimes begin feeding the migraine cycle instead of calming it.You'll discover:

Exercise can be one of the most helpful tools for migraine prevention, but when your body is already under strain, the wrong intensity can sometimes push you toward an attack.In this episode of Migraine Heroes Podcast, Diane Ducarme explores why movement can both support and challenge a migraine-sensitive nervous system, and how to find the level of exercise that works with your body rather than against it.You'll discover:

Show SummaryOn today's episode, we're having a conversation with Military Intelligence and Civil Affairs Veteran Rebecca Monaco, co-founder of Next Mission, an organization dedicated to empowering and supporting resettled Afghan women veterans who served alongside U.S. Special Operations forcesEpisode Partner:Our sponsor this week is Aetna, a trusted health care company, committed to serving Veterans, military families, and caregivers through meaningful, community-centered care. Provide FeedbackAs a dedicated member of the audience, we would like to hear from you. If you PsychArmor has helped you learn, grow, and support those who've served and those who care for them, we would appreciate hearing your story. Please follow this link to share how PsychArmor has helped you in your service journey Share PsychArmor StoriesAbout Today's GuestRebecca Monaco, MPH, is a public health leader, researcher, and program strategist with more than ten years of experience leading complex initiatives across healthcare, nonprofit, government, and military organizations. She earned her Master of Public Health from Dartmouth College, where she developed a passion for behavioral health research, implementation science, and innovative approaches to improving care. Her current interests focus on psychedelic-assisted therapy, women's health, and translating emerging research into real-world impact.A former U.S. Army Civil Affairs and Intelligence Officer, Rebecca deployed to Afghanistan as a Cultural Support Team (CST) member with Joint Special Operations Command, where she served alongside Afghan Female Tactical Platoon (FTP) members. Following the fall of Afghanistan, her team coordinated the evacuation of 42 Afghan female Special Operations personnel, an experience that continues to shape her commitment to service, leadership, and advancing opportunities for vulnerable communities.Rebecca currently serves as the volunteer Project Manager and Board Secretary for NXT Mission, where she leads initiatives supporting refugee resettlement, education, workforce development, and long-term integration for displaced Afghan women and families across the United States.Links Mentioned During the EpisodeNext Mission WebsiteNext Mission on LinkedInPsychArmor Resource of the WeekThis week's PsychArmor Resource of the Week is a previous episode of the Behind The Mission podcast, episode 184 with Kari McDonough. Kari is Vice President of Welcome.US and Senior Advisor to the Welcome Fund, a program of Welcome.us that provides a source for grantmaking to organizations as they involve community members to welcoming coalition allies coming to the US as part of resettlement efforts. You can find the resource here: https://psycharmor.org/podcast/kari-mcdonough Contact Us and Join Us on Social Media Email PsychArmorPsychArmor on XPsychArmor on FacebookPsychArmor on YouTubePsychArmor on LinkedInPsychArmor on InstagramTheme MusicOur theme music Don't Kill the Messenger was written and performed by Navy Veteran Jerry Maniscalco, in cooperation with Operation Encore, a non profit committed to supporting singer/songwriter and musicians across the military and Veteran communities.Producer and Host Duane France is a retired Army Noncommissioned Officer, combat veteran, and clinical mental health counselor for service members, veterans, and their families.  You can find more about the work that he is doing at www.veteranmentalhealth.com