Podcasts about Serum

Bryan Gee back in the hot seat bringing you the freshest Drum and Bass from Planet V and beyond. Playing fresh beats from Alibi and DJ Marky, Benny L and Darrison, Paul T and Edward Oberon, Bladerunner, Acuna, Heist and many more. The 30 Years of V history lesson continues with some classics from the vault from Krust, Die, Dillinja and Roni Size. 01. Alibi, DJ Marky and Charli Brix - Matural Feeling 02. Break and Charli Brix - Lost 03. Pennygiles - Life Goes - Montha Remix 04. L-Side - Life Goes 05. Bluemode - I Don't Even Know 06. Carlito - Sing It Now 07. DJ Marky - Cozy 08. Critical Impact - Place to Hide 09. Paul T and Edward Oberon and Jaki Graham - Reminesse 10. Jumpin Jack Frost, Paul T and Edward Oberon - Untitled 11. Darrison and Benny L - The Bravest 12. Sigma and Doktor - Trouble You - Watch Da Ride Remix 13. A-Audio - Highway feat. Parly B 14. L-Side and Natty Campbell - Watch Dem feat. Natty Campbell 15. L-Side and T.R.A.C. - Killer Transmission - Level 2 Rollers Mix 16. Heist - Harlots 17. Bladerunner - Straight Up 18. Alibi - Greed 19. Zoro and Addicted - Badness 20. Inja - Step by Step 21. Chimpo - All of the Above 22. Unknown - Bad Girl - Potential Badboy Remix 23. Acuna - Played with Me 24. Clipz - Joy and Pain Remix 25. Paul T and Edward Oberon - Somewhere Else - Serum Remix 26. Break - Another Life 27. Alibi - It's All Good 28. SL8r - Cause for Alarm 29. Melinki - Radical Sounds 30. Loxy - Choices VIP 31. Carlito - Shavana Rain 32. DJ Krust - Unknown 33. DJ Die - Nasty 34. Dillinja / Trinity - Henessey 35. Dillinja / Trinity - Jah 36. Dillinja / Trinity - Funk Will Flow 37. Krust - Poison - Shy FX Remix 38. Lemon D / Afro Kid - Shooks 39. Kitachi - Spirit - Roni Size Remix 40. Dillinja - Lion Heart VIP 41. Paul T and Edward Oberon - Where Do We Go - Survival Remix 42. London Elektricity and Robert Owens - My Dreams - Zero T Remix

Our guest this week is Mert Mumtaz, Co-founder & CEO of Helius, a vertically integrated developer platform offering a suite of tools to help easily build products on Solana. Mert joins Brian Friel to clear up common misconceptions about Solana, shares the latest opportunities for developers, and dives deep into state compression, which reduces the amount of on-chain storage required to store NFTs, resulting in lower costs for creators and buyers by up to 100 times. State compression on Solana is already being leveraged by projects like Dialect, Drip.haus, and Helium to help scale their projects. Show Notes:01:10 - Origin Story and background05:08 - How he started on Solana07:45 - How Helius began11:27 - Misconceptions about Solana      18:01 - What is he most excited about on Solana23:03 - How is Helius working with DePin25:34 - Opportunities for Developers on Solana32:15 - A builder he admires          Full Transcript:Brian (00:06):Hey everyone and welcome to the Zeitgeist, the show where we highlight the founders, developers, and designers who are pushing the Web3 space forward. I'm Brian Friel, developer relations at Phantom, and I'm super excited to introduce my guest, the man who in Solana needs no introduction. Mert Montaz, the founder and CEO of Helius. Mert, welcome to the show. Mert (00:25):Thank you for having me, Brian. Brian (00:26):I've been looking forward to having a conversation with you here for a while. I don't know if you remember this, but way back in the day, I was getting my start on Solana by writing articles on Twitter, dev related articles, and you were one of the first people that took my article and said, hey, I'm an engineer at Coinbase. I can actually vouch that this is legitimate. And that actually got me in front of Chase Barker and everything. I don't know if you remember that interaction, but it's been a long time that I've seen you on Twitter. Mert (00:54):I do remember it. Brian (00:55):Thank you for that because that got me my stardom of three. Maybe that'd be an interesting place to start is I'd love to learn a little bit more about you. I know you were, previously before getting involved with Solana, you were at Coinbase. Can you share a little bit about your journey, what your background is and what led you to Solana? Mert (01:10):Yeah, absolutely. First of all, I do remember that interaction. I think it was a medium article about it was either voting or incremental counter, maybe a peanut butter sandwich or something. Brian (01:21):Yeah. It was like a simple app. Mert (01:22):Yeah, it was actually quite good. I was super impressed with it. I wish people kept producing those. I think we need more brine blog posts. Yeah. I guess maybe a brief intro of how I got started. I majored in math and communications engineering, communications engineering being satellites and signals and stuff like that. And I actually got to work at Blackberry as an intern. And so I got to see some pretty interesting engineering challenges at my earlier years about cloud infrastructure. I was on the team that ran the cloud for BBM, for example, which handled a lot of volume until it died, of course. Yeah, I mean after that I worked at the big banks in Canada, Canada's run by five big banks and I worked at three of those in some weird order where I did cybersecurity, I did payment systems, ATM withdrawals and stuff like that. (02:11):And I then joined a startup that got acquired, Shutterstock. It was about digital advertising and stuff like that. I'm sure some people are familiar with Shutterstock. And then I worked at Clear Bank on the treasury team where we were in charge of payment rails and stuff for funding entrepreneurs. And then we had this situation where we needed to send money to Australia and I needed to write the code that would handle doing that. And we met with a bunch of these vendors and stuff and it was all super complex for some reason that I didn't understand, you had to do these hops through various jurisdictions and stuff like that. And I was like, I mean you could probably just use USDC or something. And people just thought that was a scam. And at that point I was like, I wonder what the actual truth is here. (02:55):I did some digging and I was like, this is obviously not a scam, not even close. And in fact, it seems super interesting. I did a brief look into crypto in university where I thought I was maybe too academic and you need a PhD or something to do anything meaningful. Obviously quite wrong, but that was my first intro. And then a few weeks after that I was working at Coinbase. Actually it was interesting because I joined them slightly before they went public. And so they still kind of had the startup ethos and it was super fun working there and got to learn and build and talk with a bunch of really bright people. And that's obviously doing research on different blockchains. Obviously Coinbase is very EVM centric. Some times were good, some times we're bad. And somewhere in that line I found Solana and I just started digging around posting stuff, publishing stuff. And I really liked the approach that Solana had taken to be the pragmatic approach. I'm sure you hear this word a lot, but the practicality of the ecosystem as well as the ethos really resonated with me. (03:52):And the community was also pretty cool. You actually just mentioned Chase talking to you about something you posted. That was also my experience. Whenever I would posted something, Armani or Chase would hype me up and I was like, okay, that's pretty cool. And yeah, I mean it kind of just took off from there. Brian (04:07):Yeah. I love that framing of the pragmatic chain and you actually having that experience at a big bank just saying, why don't we just use USDC? It's settled in 400 milliseconds or whatever. And Solana really, I think, is the best example of that. That's pretty poetic that you found your way there. Mert (04:23):Mm-hmm. Brian (04:23):I remember a time though when you first were posting on Twitter, it was mostly around trying to help others understand what was happening on chain. And you mentioned Coinbase, very EVM centric. I think a lot of us who worked in crypto at the time, it was just EVMs the only game in town. And if you thought differently, that was just weird or a lot of people it didn't make sense. And I think my experience, one of the biggest barriers to getting people familiar with Solana was just wrapping their head around the mental model of just how stuff works on chain. It's just inherently different. Can you talk a little bit about that, how you got your start? What were you doing when you were writing these articles and helping others understand what was going on on chain? What did you have to build, what were you teaching yourself at that time? Mert (05:07):Yeah, that's a good point. Most people actually don't really know that unless they were early like you. At first what I would do, this was kind of during the peak kind of start of NFT season on Solana and basically a lot of influencer types or people who I don't think were very intellectually honest would post some sort of claim about, oh, the price of the NFT is going down because the price of Solana is going up. This is obvious and stuff like that. And I thought to myself, there's no way the markets are that efficient for JPEGs, right. There's other stuff there. If people were botting these NFTs and getting a high concentration on maybe dumping on retail and doing other sketchy stuff. And so I would just write scripts, goal length scripts or JavaScript scripts, whatever, and analyze the data. This is before any data analytics existed, really like Solana FM or I mean, Solana FM was there, but they did regular indexing, Solana floor and stuff. (06:09):Flip side, Nance, none of these actually covered Solana. I would just do it and then I would just write my findings in a Twitter thread with some charts and stuff. And I did that pretty regularly. I did it for a bunch of different stuff, including some upcoming projects in terms of gaming and where the potential is. And somewhere along the line after being armed with that knowledge of just doing it for a consistent amount of time, I came across a lot of people on crypto Twitter just really making unsubstantiated claims about Solana and its architecture and its scaling plan and all this stuff. And I guess I was in somewhat of a unique position where I was actually still at Coinbase at the time and somebody would post something and I had relatively okay knowledge of EVM, but also pretty good knowledge of Solana. (06:56):And so I'd usually be able to tell, okay, this is just not true what this person posted. Why is nobody correcting them? And it's because nobody actually just really knew both ecosystems that well. And sometimes in internal Coinbase chats, this would come up and people would be like, that is wrong. And I'd be like, yeah, that is wrong. Why aren't we doing something about this? And I kind of just started yelling at the people who were just lying or maybe spreading knowledge that was not grounded in truth, let's say. And I just never stopped doing that. And turns out crypto Twitter is full of these people, and so I never- Brian (07:29):Yeah. Your job's never done. Mert (07:30):Exactly. Brian (07:32):Is it fair to say that you arming yourself with this knowledge, you had to actually build the tools you needed just to understand what's going on-chain. Was this the start of Helius and essentially what you guys now offer? And maybe you can talk a little bit about that, how Helius began. Mert (07:45):Yeah, 100%. That's exactly right. The most common problem I ran across was when you're looking at on-chain data, the data is super cryptic, right. The instruction data is bortion coded or something. And unless you knew the schema of how it was encoded or maybe the idea which, especially in NFTs, in DeFi, it's not too bad, but especially in NFTs and other non-DeFi use cases, nobody has any idea what the on chain data looks like. And so I would have to hard code some weird methods, maybe parse logs, but also reverse engineer based on discriminators. Or I would even try to brute force it sometimes, which actually kind of worked. I would go on Magic Eden, and you would know this is before Magic Eden's programs were more readable. This is the first version. I would check the app layer. I would go to magiceden.io and I would see, okay, this NFT is listed for 20 SOL or something. (08:38):And then I would try a bunch of different decodings until I got that answer. And then I would do that with a bunch of different ones and I'd be like, okay, this is clearly the discriminator that I need to use. And so I would do that. I also did a bunch, go to the network tab, inspect source, and then dig through the entire minify JavaScript, unminify it, see the schema and try to use that schema when trying to decode the data and stuff. And I was like, this is bananas. This should not be done. And basically that's kind of where Helius came from and the first iteration of Helius was like, okay, we need to make on chain data read about Solana because it's particularly impossible. And then along the way, once we started doing that and talking to customers, it seemed like quite a few people were having other problems, especially around RPCs, which was surprising 'cause I thought RPCs were kind of okay, but after digging into it, it turns out that wasn't really the case. (09:28):And then you run into all sorts of other issues like streaming data on chain, at least in an inexpensive and reliable way. Solana has this problem with web sockets where you might lose data. Yeah, I mean just talking to customers just found a bunch of problems. And Helius is essentially now there to be this vertically integrated developer platform on Solana to essentially just help developers succeed on Solana. And we're not necessarily bound to Solana, but basically my philosophy on this is that I want crypto to succeed. I mean obviously we're all here because we're interested in crypto and believe in crypto's future. If you start from first principles there, I think given the options out there today, Solana's our essentially best shot at executing that vision. Obviously a lot of people disagree with that, but it's something I believe in. And so then my thought process, okay, how do we get more people to build on Solana so that we can have a better crypto future? Brian (10:19):No, I totally agree with that. I think that's been our ticket on Phantom as well, where it's like most of Phantom came from EVM folks and I think a lot of us independently kind of had this realization of we want crypto to succeed. Pragmatically thinking, what am I going to get my parents or my friend to use today? How are we realistically going to scale this thing in the next couple years? Solana also right now is the most pragmatic approach to doing that. I think before we jump in a little bit more to Helius in particular, what you guys offer and what you guys are up to, I kind want to take a moment just to talk maybe broadly about Solana because I think you are one of the most well known vocal defenders of Solana where there is a lot out there that's just blatantly wrong and you not only technically know how to rebut it, but you take the time and the energy to be out there and educating people. I want to know a little bit for where you sit at Helius, what you see right now, what would you say are some of the biggest misconceptions today about Solana that folks who maybe already know about crypto, maybe are already well versed in EVM, but maybe they just haven't gotten through to actually hear from somebody's boots on the ground. What would you tell them that they're misunderstanding about Solana? Mert (11:27):Maybe I'll take a more broad approach to answering this because it's kind of different segments, but in terms of maybe people from EVM, if you're already familiar with EVM and maybe you want to build on Solana and what are your kind of reservations, right. Some of the ones I've come across are, well, one, Rust is just hard to write. Solana has a diehard kind of fan base of Rust developers, but Rust is not easy. That is just a fact. Solidity, is somebody in high school could learn it easily, but Rust, I mean they'd be able to learn it, but I don't think it'd be easy. The concepts like lifetimes and for example, that stuff is not easy for somebody who wants to just prototype and maybe ship something. And so then you'll say, well, there's Anchor and stuff and Anchor is super helpful and probably my favorite tool on Solana, unless you know Rust, you're still going to be kind of flying blind and you know might need that to build your applications. (12:17):And if you're a determined developer, you'll get over that and then learn Rust anyways. But that friction alone is enough to deter a good amount of people is what I found. That's just one thing, and I know Foundation folks and Dev are working on this and there's some other teams, there's the Python seahorse stuff, there's a new type of Script One coming out. I think maybe there's even a Goaline One. It's also just a result of being early. Solana has really been around for two years, whereas EVM almost nine years now. It's hard to compare these things. That's one. And then two, and this is an interesting one, is developer optionality. As a developer, let's say at an entering focus from Coinbase, let's say you want to build a new product and  you're deciding between EVM and Solana. Well, the obvious kind of elephant in the room is, okay, if Solana has a problem, you are kind of done, right? (13:12):You don't have any other options. You can't port your code base over anywhere else. Whereas if you are the EVM developer and you build on Polygon, you can just use main net Eth, maybe you can, with some effort, use any of the other L2's or maybe another EVM for it, something like that. It's a much easier transition. It's less risky such that on a design doc that you want reviewed by product managers, most engineers are going to take the safe route there. Brian (13:37):It reminds me of that “no one gets fired for hiring IBM” phrase that they used to have back in the day, the safe route to get it approved by somebody. Yeah. Mert (13:45):100%. And it doesn't help that the Solana PR is so bad that everybody's even mistakenly saying, oh, Solana always goes down or Solana's all these different things. You add these up and then as an engineer, if you're at a big firm and you pick Solana, you have to religiously fight or justify your position. And most people just aren't going to do that even if they believe it. That's a big problem. One of the reasons why I think more SVM roll-ups that sell on other chains might be interesting here to give developers more optionality such that if you build on Solana, but Solana has something bad happen, but it's still settling on these other L1's or other data availabilities or whatever it might be. And then three, is of course, there are actual misconceptions about the reliability of the chain. (14:33):People think the chain has gone down 12 times or something, or multiple digits. It's actually gone down four times. People conflate performance degradation with outage. Performance degradation is just when you maybe have, you guys obviously notice at Phantom when you maybe aren't landing transactions on chain or maybe there's latency or something like that, that's the functional equivalent of fees getting higher on EVM. That's performance degradation. But an actual outage is actually relatively rare. In fact, the numbers, I think the last time I looked at them were 99.7% uptime, which isn't perfect, but it's also not bad. It's certainly not as bad as something that would go down every day or regularly. I mean there's a misconception there. Brian (15:15):Or reorgs in that matter too. Mert (15:16):Yeah, exactly. I mean we can kind of talk about that in maybe another part of this, but people don't realize that especially for an indexed company, maybe Coinbase where you're selling funds, those reorgs actually affect your architecture an insane amount because you need to add new systems to communicate, oh actually this block was not correct or something. Whereas on Solana, you don't really need to do that. I mean no block to my knowledge went back after being confirmed. Brian (15:40):Yeah. I was going to say I don't think there ever has been a... It's even, yeah, the optimistic confirmed, not even finalized as there's never been a reorg once it's been that. Yeah. Mert (15:49):Exactly. Some people think you need ridiculous hardware requirements to run these nodes and that's actually not true. You can run a node, depending on if you want an RPC node or a validator node for really anything from $200 to $800 a month. People think you need actual data centers to run it, which I don't know where people get that from. And then there's also light clients coming out now, right. I can talk all day about the misconceptions, but I think the first two are probably the most justified reasons from actual engineers that I've heard. Brian (16:20):Yeah. No, that's a really good take, I think, because one, there's the FUD, which I think is the back half of what you kind of just talked about, which I think that just comes with time and getting people to experiment with Solana and trying it firsthand and understanding there's no better teacher than that, otherwise you're fighting essentially Twitter algorithms. But I think that's a really nuanced take what you had to start, where you're saying the de-risking almost to get this buy-in because you know what it's like to work at these large companies and kind of proliferating Solana there. I also think what Jump is doing with Fired Answer is also just another benefit to that as well. Essentially just reducing the service area potential bugs that occur. Essentially if you have a bug in just one client implementation, adding a second one greatly reduces the chance it'll happen again. (17:09):Maybe one way we can take this is instead of fighting the FUD, because that could take all day, is from where you sit right now in Helius, say that you guys have a really interesting position in the space because one, you're super close to what's actually happening as Solana's roadmap evolves. I'd say part of being the pragmatic change is Solana's not afraid to push the boundaries, take risks, add new token programs, NFT compression, just constantly evolving at a fast pace. You guys are close to that and then you're also close to the developers who are coming into this space for the first time, like you said, the hobby weekend developer who's interested and they don't want to learn Rust and so they need some sort of abstraction layer to this coming in some sort of dead platform that's helping them in some way. What are you personally most excited about right now that's happening on Solana? Mert (18:02):Well, I mean Compression, I think, maybe is one that's gaining some steam in and an obvious one that I think most people are aware of at this point. But back when I was trying to show it, most people weren't aware. I think our job here is maybe done so now it can kind of take off, but Compression is super exciting because most people don't realize that Compression, actually, let me just explain what it is first. Data storage or state storage on Solana is quite costly. I don't know the exact cost, I guess I would need to look at that chart, but there's some articles on this and you can look at the Helius blog "shill" for seeing the comparisons for the numbers, but basically state storage on Solana is expensive and with Compression, essentially what you can do is instead of storing the data in state, you can store it on ledger. And that might sound a little abstract, but basically instead of needing it for consensus, you securely log it in transaction logs. (19:00):Basically it's what an engineer would call a stateless accumulator. I call them L2 because I like doing random marketing stuff, but Toly really doesn't like it. Do not call it an L2. Call it a stateless accumulator, which isn't very beginning friendly, but that is actually what it is. You just store a reference, it's a pointer by reference kind of thing. You store a reference to the data that's on the ledger on the state now instead of storing all the data on the state. And we do that via Merkel Trees, which I'm not going to go into here, but essentially you're able to get a few orders of magnitude and cost reductions. Now that's useful for digital assets and that's the first use case, NFT compression where you can mince thousands, millions, billions of NFTs. People will say like, oh, why do you need to mint a million NFTs, billion NFTs? (19:45):And it's like, that's not the point. The point is that we're not limited by technology anymore, whereas before we were, and we can maximize the design space and explore some things, right. You have Dialect doing sticker packs, Cross Mint using their APIs for all sorts of different cases, including loyalty programs, Helium migrating over to Solana for their hotspots using Compression, driphouse doing airdrops, Render potentially using it for their scene graphs, which is a super cool concepts, high map results even using them. And so it clearly has some use, but the cool thing about it is it's not actually limited to NFTs. Actually you can apply to any account, you can extend it to be fungible tokens and also just general account compression, which I think the guys at Gum are doing for some social graph formatives. It actually has quite a bit of potential there. (20:28):That's one of the big ones I'm excited about since my name is Compression Mert on Twitter right now. And then the Solana mobile, the Saga phone is awesome. I had a test unit and I've been an Android user my whole life after Blackberry Force and it's the best Android phone I've used and it's super snappy, very good build quality and it actually has changed my consumer behavior somewhat where actually, before I would explicitly shy away from mobile first or mobile crypto apps, I wouldn't use crypto at mobile at all. But now I'm like, okay, this is actually pretty cool. I can use leverage my secure seed vaults. We do need to work on that naming, but I can use that and have that confidence and that seamless integration. You have apps like Otter, Finance, Tip Link, Get Code or I guess just Code Wallet, which enables super fast kind of P2P payments, something like Venmo. And actually, I have used all of these to make payments to my family members and friends, so I'm super excited about that. (21:27):The thing I'm most excited about on Solana is this narrative of decentralized physical infrastructure or deepen taking off with not only do you have Helium now and High Mapper, you also have Render Now, Pollen Network, Genesis Go, Teleport and let's see who else we can get over. But I think this kind of intersection of P2P networks and using crypto to actually enable change in the physical world is super interesting and something that wasn't really possible before. Brian (21:56):That's super cool. I should say just for the listeners that we are recording this on April 13th, 2023, which is the official Saga launch day, so it's topical to bring that up. We're super excited about that too. I just think it's awesome that they're not afraid to push the boundaries on that. I mean for us at Phantom to not even have the ability to see a user seed phrase and it's just completely abstracted away at the hardware level, I think is awesome and a glimpse of where this is all heading. Let's talk a little bit about DePin too because I'm not as up to speed on that. I don't know if most of our users are. I think Helius migration is happening soon, TM, like this month in April. What are you guys seeing there? Is there any major changes to what you're doing on the infrastructure layer that's going to have to adapt for this? Do you foresee any major changes to end user behavior? (22:46):Part of what's interesting about Solana is the fee markets can adjust on a per piece of state level as opposed to if it was on Eth, you could see all of a sudden all your gas fees are increasing just like it would on a crazy NFT mint day. Can you talk a little bit about how you guys are working with this new DePin movement and what you guys are seeing? Mert (23:05):Helium particularly is interested in using Compression, or I mean they are using Compression to represent their hotspots and it would cost them just too much money to work with that kind of stuff on any other chain. And so Solana is what makes the most sense. And like you said, the independence of state, which causes individual account based fees as opposed to chain level fees, which doesn't make the UX horrible for one person here either. It's just you might have to pay extra. And so compression is something that they use the most, both High Mapper and Helium and also Render is, I believe, going to use it. They mentioned this in their GitHub migration paper. And so that's kind of the main driver, but also these teams generally have to subscribe to on chain events. And as a larger engineering firm or maybe independent of size, most people prefer getting data pushed to them instead of setting up some polling system to listen for events because there might be issues there. (24:02):They actually use our web hooks and then they kind of configure what events they want to listen to and then they kind of have this ease of mind where, okay, Helius will just stream me these events as they happen and I can just kind of plug, play and then forget. If anything happens, Helius will kind of let me know or maybe I'll get a page or something. The web hooks have actually been, it's interesting. When we first came to Solana, there was no web hook products on Solana and I'm not even sure if there was anything like that on Eth. It was just such an obvious thing and we built it and we shipped it and for example, Discord uses that for their integration into Solana. Their first actually Web3 integration, or actually I don't like the term Web3, their first crypto integration was with Solana and that was enabled with the Web hooks and we have some other big names using them now as well. (24:47):I don't think those are announced yet, but it's such a simple primitive, but just web hooks and listening to on chain data really helps some of these bigger firms who don't want to spend the time writing all this complex infrastructure code and they can just plug and play into some existing solution. Brian (25:02):Yeah. It's future-proofed, essentially. They can build once and they don't have to constantly be readjusting their implementation. Mert (25:08):Exactly. Brian (25:08):That's awesome. Turning this back to a developer who is maybe listening to this, familiar with EVM, looking at Solana, you guys do a lot, not just on the infrastructure side, but also on developer education, getting developers involved. We can talk about some of the specific initiatives there, but at a high level, what would you say are some of the biggest opportunities for a developer today who's looking at Solana? Where would you guide them to get started? Mert (25:35):Well, one thing I'll say is that Solana has maybe two main things that I would mention that might be interesting for folks coming over. One is that it's much earlier than the other ecosystems. And so there's a lot of low hanging fruit and underdeveloped tooling infrastructure, application layer stuff that exists in other chains in some form, but not on Solana. And so as a developer, let's just try to build something and you'll notice what's missing. You'll notice that the deployment workflows aren't great. You'll notice that maybe the monitoring isn't that great either, or maybe it's easy to shoot yourself in the foot with certain types of smart contractors and stuff. You'll notice a ton of problems and that's just your opportunity to make something cool and fix those maybe as open source, maybe as a public good, maybe as a company. And so there's a lot of potential there. (26:22):Another thing is that Solana's architecture is, and so this almost kind of contradicts the first point, but not really if you think about it. The architecture of Solana is so different, right. It's functional based where you have actually a lot of modularity within the layer. You have independent state and logic, you have different accounts, localized fee markets, and so it's much more modular than something like ETH where state and logic are coupled. And also obviously the scalability features of Solana are quite different than anything else. And what that means is there's a lot of things that you can actually build that's only possible on Solana. Brian (26:57):I love that catchphrase by the way, only possible on Solana TM. Mert (27:01):Yeah. I've been a big fan of that one, let's just say. And it's totally true, right. Order books, for example, you saw it with Serum, you're seeing it now with Phoenix. This is before Fire Dancer and before 200ms block times, which will happen. This is the slowest it will be, it's only going to get faster from here. And so there's a bunch of things that are only possible on Solana. And I would strongly encourage people to think from first principles as a developer, look around, see what problems there are. They don't have to be Solana specific, they can just be problems, right. I don't know, maybe it's too slow to send your dad money or maybe it's too hard to offramp crypto, I don't know, something like that. And then usually if you are trying to look for a solution there for that problem, Solana will be able to handle it much more comfortably than others. (27:47):And the other important thing is it'll actually scale, right. You want kind of elasticity as a developer such that if your app takes off, you don't want to have to now migrate to another stack or something. With Solana, it's honestly just plug into a cloud provider, just kind of scales with you. But also a third thing I'll actually mention, which this really should have been number one, but I would encourage you very, very strongly to produce content, especially developer related content. Build something, learn from it and then write about it, make a podcast, produce a video, produce a tutorial, just write content. And not only will that obviously help you connect with other people who are in the ecosystem and like-minded and building other cool stuff, but also when you write stuff and produce content, you have to know what you're talking about, otherwise you won't be able to write it, right. It'll make you connect the dots and it'll point out flaws in your thinking. Brian (28:44):Yeah. It's the fastest way to get the right answer on the internet is to publish something that's wrong. Mert (28:49):Exactly. And so I guess maybe to go along with that is just have a high tolerance for looking, I don't want to say stupid, but just have a high tolerance for being wrong. You're going to be wrong a lot, but that's not a bad thing unless you're building the infrastructure for handling, I don't know, some critical payments or something. But you're probably not going to be doing that. Brian (29:10):Yeah. It's like the pursuit of truth. If you're open to that and you're excited to get told what's right, I couldn't agree more that's 100% the best way to build. Mert (29:19):Yeah. Sometimes I'll post something that I think is correct, but it's not apparently actually correct because Toly will comment and he'll gently say something that's slightly unrelated, but it's like, oh, okay, I'm wrong, I guess. I will retract this. And so honestly, it's just a fun way to learn and you do enough cycles of that and you are going to be doing that to other people and that's how we grow. Brian (29:46):Yeah, I totally agree. I think this ties in with what you were saying earlier of Solana being the pragmatic chain. I think part of the benefit, there's a knock, we talked about it, about, hey, Solana's new, it's different and you're essentially fighting network effects at that point. But part of the benefit is you get to build your own genuine kernel of a developer ecosystem and start from first principles and start from new and not be afraid to change things new. And I think that's been pretty eye-opening, even just to me personally. As Phantom enters EVM, we're looking at everything that EVM has inherited over the years. Most obvious one being even just how injected wallets play with each other on EVM is so different than Solana because Solana took a very first principles approach and said, we're going to do this in a way that you have a wallet, you can use it anywhere, it's going to scale forever kind of thing. And it's been pretty eye-opening to see the differences there. (30:36):That would be my only other thing I'd add to you is if you are a dev and you want to make it high impact on, it's probably the best place for it because you can post publicly about why you're doing what you're doing and you'll get people who are interested in listening and will back you on the basis and the merits of your ideas is what I'd say. Mert (30:52):Yeah, absolutely. Me, Chase and other parts of the developer system will help you the best we can. Basically the Helius tagline is actually “Where Solana teams succeed” because our entire goal is to help you succeed. That's essentially why I wake up and that's what I spend my entire day doing. And the Phantom founders, for example, are great example of this, right. They came from EVM and they saw what was possible on Solana and they built the number one wallet in crypto and it had such good UX and such good design and stuff, and you guys absolutely dominated. And then now you're actually transcending the change, right. It's actually becoming a product, it's not just a chain's product, it's just a product that you can use to onboard people onto crypto. I really like that approach from starting from first principles like you guys. You saw Meta Mask and you're like, okay, well we're going to do it differently. And you did it much better in my view. And so I think that's just an example of what's possible. Brian (31:50):Thanks. Yeah, I mean we love hearing that, but obviously love everything that Solana's doing and Solana's always going to be home. There's a lot to do on Solana. I'm excited to roll up the sleeves this year and get started. I guess, Mert, and as we start to wrap this up, one question we always ask all our guests, I'd love to hear this from you. You mentioned a lot of people on this podcast, a lot of teams, but I'd love to know, is there a particular builder that you admire in the Solana ecosystem? Mert (32:17):Oh man. I mean, I do admire my co-founders, to be honest. I don't think they got that much credit because I'm kind of the loud one, but Nick and Liam are super, they're actually the driving force behind Helius and they do all of the engineering, and I do essentially nothing other than just larp on Twitter. Them for sure, but also, I'll give you my general approach on this, actually, maybe this is useful for someone, but my general approach to Twitter is whenever I see a founder on somebody's bio or something like that, or maybe a co-founder or something, I'll immediately follow them because those people are super inspiring to me. I pretty much follow all the founders on Solana at this point, I think. For example, the founder of Squat, Stephan Wright. I saw him, I was like, I'm going to follow this guy. (33:01):Turns out amazing dude, we're friends now. That's my general approach. I just respect all the founders in the ecosystem because they're taking big risks and they're trying to build cool stuff, and they're all trying to help the ecosystem. And so I have just huge respect for everyone there. Someones, I would probably point out specifically, would be obviously Armani and Tristan, huge respect for them. The founders of Gito, right, Sec, Fault and Buffaloo, I'll just say their pseudonym names. Co-founders of Squads, right, Margin, Drift, Zeta, for example. All the DeFi protocols. I'm probably just going to end up listing literally every single one. I would say if there's one particular one, it would be, I guess honestly just Toly, right. That's probably a cliche answer, but Toly just always keeps his composure under people just relentlessly slinging mud at his life's work essentially, and in a super unfair way. And he still gets up. And I mean, not only does he engage with the community, but he still builds cool stuff and there's so many different things. I have no idea how he does it, and I have a ton of respect for that. Brian (34:08):Well, I think that's the perfect answer. Having listed all the major founders in Solana, and then you go back to the guy who started it all, he sets the tone for the space and I think he makes it that drama free, practical, pragmatic, how do we build practical that's useful today. That's been my answer secretly too, that no one's asked me, but... Well, Mert, this has been awesome. Thanks so much for coming on. We'll have to do this again later once we've shipped all these crazy upgrades to Solana and check in again. But where can folks go to learn more about Helius? Mert (34:42):Yeah. Just helius.xyz. You can just go there or you can just @ me on Twitter. That's honestly how most people get in contact with me. Just tag me on Twitter on something and I'll respond. Brian (34:50):Awesome. Love it. Mert, the founder and CEO of Helius. Thanks so much for coming on. Mert (34:54):Thank you for having me.   

Did you know that by the age of 40-50, people have anywhere between 10 to 30% senescent cells in their tissues? Senescent cells are one of the hallmarks of aging, and can disrupt physiology throughout the body.Welcome to another episode of the Biohacking Beauty podcast brought to you by Young Goose Skincare! In this episode, host Amitay Eshel, the CEO of Young Goose, is joined by Dr. Nick Bitz, an expert in ayurvedic medicine, to discuss senescent cells and how to eliminate them for improved health and appearance. We also cover why the industry is evolving away from anti-aging to a wellness movement, and how the focus is on enhancing health rather than fighting disease.Dr. Nick Bitz is a naturopathic doctor who combines traditional and modern medicine in his practice. He has a Bachelor's degree in Biomedical Science from the University of Guelph and a Doctor of Naturopathic Medicine degree from Canadian College of Naturopathic Medicine. Dr. Bitz is passionate about helping his patients achieve optimal health and wellness using a holistic and individualized approach. He uses a variety of modalities including nutritional and lifestyle counseling, botanical medicine, acupuncture, and homeopathy. Dr. Bitz is particularly interested in brain health and optimization, and has developed a supplement line called Qualia to support cognitive function and overall wellness. What we discuss:[00:02] Understanding senescent cells and approaches to eliminate them to improve overall health and appearance.[07:19] Why the industry is evolving away from anti-aging and towards a wellness movement.[13:36] Why senescent cells are one of the hallmarks of aging.[19:30] Senescent cells are dead cells that infect surrounding cells, leading to disruption in the body.[25:39] Finding ways to eliminate senescent cells can improve body function and performance.[31:37] Synolytic compounds are effective in disrupting pro survival proteins and allowing cells to naturally prune away through apoptosis[37:43] Supporting autophagy through fasting or calorie restriction can help eliminate senescent cells.[43:56] Senolytics can lower inflammation load and stimulate body repair.[50:02] Pro C.A.R.E. Serum and C.A.R.E. Moisturizer contain senolytic compounds.Key Takeaways:Longevity is replacing the term anti-aging, and it is important to focus on healthspan rather than just looking younger.Senescent cells are one of the hallmarks of aging and can disrupt physiology throughout the body.Our Pro C.A.R.E. Serum and C.A.R.E. Moisturizer contain senolytic compounds to help clear senescent cells over time.To learn more about Young Goose:Website: https://www.younggoose.com/Instagram: @young_goose_skincareGet 20% off your first purchase by using code PODCAST20 at www.younggoose.comTo learn more about Dr. Nick Bitz:https://neurohacker.com/Instagram: @neurohackerTwitter: @theneurohacker

Jon Jordan talks to Lior.eth from Mutant Cartel and Alex Paley from Faraway Games on their collaboration Serum City, a forthcoming citybuilding game that uses both Bored and Mutant Apes and Mutant Cartel's own NFTs to create new narratives and experiences. We particularly discuss the concept and actualities of NFT interoperability.

Serum de $500 dólares de la marca “La mer”. Compras de productos por marcas conocidas y marketing agresivo.

Is there a difference between intradermal and serum testing for atopic dermatitis? Learn the differences in what these tests measure and why testing should be recommended to your patients on this week's episode of The Derm Vet podcast!

This week, Jason & Ryan get all doped up on glowing serum as we bring some awesome conversation to life discussing Stuart Gordon's 1985 horror classic Re-animator!

This episode is in reply to one of our fantastic podcast family members who had some wonderful clinical questions regarding dosage of combination BC after listening to our past episode. In our immediate past episode, we discussed hypoestrogenemic symptoms on ultra low-dose pills in certain patients (young, thin). Is a 20 µg BC pill less thrombotic than a 30 or 35 µg pill? What does the data say? In this episode will answer this question and also dive deeper into serum estradiol levels not only with combination birth control but also with menopausal hormone therapy. Is there a “target level” of systemic/serum estrogen with combination HRT? Listen in and find out.

In 1972, a publication in which a radioimmunoassay measured serum estradiol levels in participants taking oral combination birth control concluded that levels of serum estrogen were “sufficient to prevent symptoms of estrogen deficiency”. Knowing NOW what we do, and looking back to that article, those authors' conclusions were completely incorrect! Is it possible for a patient to experience hypoestrogenic symptoms despite taking an estrogen containing birth-control? What are normal, endogenous estradiol levels in a reproductive age female? In this episode, we will review the various degrees of hypothalamic – pituitary – ovarian axis suppression from different categories of hormonal birth-control. Should certain micrograms of ethinylestradiol be preferred in thin and/or adolescent patients? Listen in and find out.

In this podcast I talk about Bio Serum and I answer questions.

In 1925, the town of Nome in rural Alaska found itself facing a potentially catastrophic outbreak of diphtheria. Almost completely cut off from the rest of the world by the harsh Winter, the only way to get medicine in was via a relay of 20 teams of sled dogs. The inspiration for the cartoon film Balto, this is the true story of the Nome Serum Run. This is a comedy/history podcast, the report begins at approximately 05:18 (though as always, we go off on tangents throughout the report)Support the show and get rewards like bonus episodes: patreon.com/DoGoOnPodLive show tickets: https://dogoonpod.com/live-shows/ Submit a topic idea directly to the hat: dogoonpod.com/suggest-a-topic/Check out our merch store: https://do-go-on-podcast.creator-spring.com/ Check out our AACTA nominated web series: http://bit.ly/DGOWebSeries​ Check out our other podcasts:Book Cheat: https://play.acast.com/s/book-cheatPrime Mates: https://play.acast.com/s/prime-mates/Listen Now: https://play.acast.com/s/listen-now/Who Knew It with Matt Stewart: https://play.acast.com/s/who-knew-it-with-matt-stewart/ Our awesome theme song by Evan Munro-Smith and logo by Peader ThomasDo Go On acknowledges the traditional owners of the land we record on, the Wurundjeri people, in the Kulin nation. We pay our respects to elders, past and present. REFERENCES AND FURTHER READING:Icebound The Greatest Dog Story Ever Told (Discovery Channel)https://www.youtube.com/watch?v=SQbJ1PNTZyo&t=10s https://www.baltostruestory.net/serumrunsynopsisp2.htm https://web.archive.org/web/20101127233139/http://www.litsite.org/index.cfm?section=Digital-Archives&page=Land-Sea-Air&cat=Dog-Mushing&viewpost=2&ContentId=2559 https://www.historyvshollywood.com/reelfaces/togo/ https://www.maruskiyas.com/nome-alaska Hosted on Acast. See acast.com/privacy for more information.

This month on the pod it's all about MC Fats, as Bryan plays tribute to one of D&B's finest, and long time friend of his and the V family. Kicking off him some upfront selection and then 2 hours of some of the many amazing tracks from the Fats cataloge spanning the last 25 years. 01. Paul T, Edward Oberon and Jaki Graham - Reminiscence 02. Break and Lorna King - Wait for You 03. Die and Addison Groove - Morro Dub (Watch the Ride Remix) 04. Solah - Everything is Possible (Marky and Makota Remix) 05. Bluemode - I Don't Even Know 06. L-Side and Frank Carter - Do 4 Love 07. Paul T, Edward Oberon and Cleveland Watkiss - Music Got Soul (Benny L Remix) 08. L-Side and T.R.A.C - Killer Transmission (Level 2 VIP Roller) 09. DJ Hype and MC Fats - Rinse Out 10. DJ Hype and MC Fats - Jack to a King 11. DJ Hype and MC Fats - Peace Love and Unity 12. Dillinja and MC Fats - I Told You How to Rock 13. Influx UK - Souls Unite feat. MC Fats and Regina 14. Calibre and MC Fats - Drop It Down 15. Calibre and MC Fats - Neighbourhood 16. DJ Fresh - Babylon Rising feat. Pendulum and MC Fats 17. Pendulum - Plastic World feat. MC Fats and TC 18. A Sides and MC Fats - Arctic 19. Blueskin and MC Fats - Something's Going On 20. Blueskin, MC Fats and Cleveland Watkiss - Feel You Too 21. Blueskin, MC Fats and Cleveland Watkiss - Hold the Moment 22. Patife, MC Fats, Dextrous, Cleveland Watkiss and Marlene da Castro - Made in Bahia (L-Side Mix) 23. Patife, MC Fats, Dextrous, Cleveland Watkiss and Marlene da Castro - Made in Bahia (Alibi Mix) 24. Potential Badboy and MC Fats - Girlz 25. Break, Die and MC Fats - Peace and Dub 26. A Sides - What U Don't Know Dub feat. MC Fats and Regina 27. A Sides - What U Don't Know feat. MC Fats and Regina (Makoto Remix) 28. XRS - Lovin (Random Movement Remix) 29. Crix and Brother and MC Fats - Middle of the Night 30. Crix and MC Fats - Colour of the Sound 31. Brother and MC Fats - True to You 32. Alix Perez and MC Fats - Down the Line 33. Andy Scopes, Madcap and MC Fats - Trouble 34. Command Strange and MC Fats - Brand New Style 35. A Sides - Temperature Rising (Command Strange Remix) 36. A Sides and MC Fats - Moment in Time (S.P.Y Remix) 37. Command Strange - Desire 38. Alibi and MC Fats - Rise Up 39. Patife Vangeliz and MC Fats - Living Together 40. Serum Bladerunner and MC Fats - Inner Source 41. Serum - Anytime 42. Chase and Status and MC Fats - Step Away 43. A Sides DJ Marky and MC Fats - Feelin Fine 44. Break and MC Fats - Free Your Mind 45. Alibi MC Fats and T.R.A.C - No Lights 46. Velocity and MC Fats - We Got You Junglist 47. Patife Dave WS and MC Fats - The Vibe is Coming 48. Alibi, Cleveland Watkiss and MC Fats - Big Man Jungle 49. Break, Cleveland Watkiss and MC Fats - We Are the People 50. Break, Cleveland Watkiss and MC Fats - Midnight Classic 51. Potential Badboy and MC Fats - Jump to da Sound 52. Break, Cleveland Watkiss and MC Fats - Conversation (Breakage Remix) 53. L-Side and MC Fats - Steppa Dub 54. Nitri and MC Fats - Vision 55. Velocity and MC Fats - Hide and Seek 56. L-Side and MC Fats - High Times 57. Paul T Edward Oberon and MC Fats - Where Do We Go 58. Alibi MC Fava and MC Fats - Mr Junglist Man 59. Dunk and MC Fats - City of God 60. Makota and MC Fats - I'll Be There 61. A Sides and MC Fats - Never Yesterday

I'm trying out a new service to decipher the audio into some nice summary and formats which you can view below the sponsor information!Be sure to thank our newest sponsor, Ruvi! Go to https://www.goruvi.com and use code packaging to get 15% off your orderIf you listened to the podcast and wanted to connect with Specright to rid the world of waste. Let's go! www.specright.com/pkg. Prepare your company for the world of EPR laws and be the sustainability hero! Make sure you check them out and join them on their mission to have a world where people are free to make amazing things!Also…Are you sick and tired of the same positions at your PLANT consistently being open or just not being filled? Or maybe your facility just isn't retaining talent due to not having dedicated recruitment support.If you need contract-to-hire support, or you are looking to hire directly for industry professionals…. Spark Packaging can help. Spark Packaging is the industry partner who provides all your recruitment and staffing needs.  If you are hearing this…and thinking “THAT'S ME”…You need to go to to SparkPackagingINC.com/HIRING , again that is SparkPackagingINC.com/HIRING and answer some of their questions. Once received a Spark team-member will reach out A-S-A-P! Tell them the Packaging Pastor sent ya!This podcast is part of a great network of podcasts about packaging. Go follow Sustainable Packaging with Cory Connors along with Packaging Unbox'd hosted by Evelio Mattos.If you want to be a guest on this podcast, or Sustainable Packaging with Cory Connors OR Packaging Unbox'd with Evelio, go to www.encasemedia.com and fill out an application for one or all!TITLE "Founder of Serum Explains Her Journey to Creating Environmentally-Friendly Packaging Solutions" SUMMARY Kahl Whiteman is the founder of Serum, a company based in Fort Lauderdale, Florida. The podcast episode is her first and she is from Salt Lake City, Utah, where it was three degrees at the time of recording. Kayl has had a very interesting life up until this point, having worked on giant yachts and other places. She has come a long way to start her own company, Serum. She talks about how her life has been colorful and full of different experiences that have brought her to the place she is in today. She talks about her journey and the importance of taking risks to reach success. She also explains the mission of Serum and how it is helping people to have better lives. Kahl encourages listeners to take risks and trust in their capabilities to reach their goals, and to not be afraid of failure. The speaker is 24-year-old who grew up in Arizona and was instilled with a passion for plastic from a young age by his dad, who works in the plastic industry. When the speaker turned 18, he decided to pursue a career in boats, working as a chef on boats from 60 foot sailboats to 200 foot super yachts. The speaker gives a brief explanation of the metric system and how it works. Her dad is still working in the plastic industry, with the company supplying the additive that allows plastic to biodegrade in landfills. The speaker's passion for packaging was influenced by her dad, and now she is taking the things his dad instilled in her and multiplying them. In the conversation, the speaker talks about their high school senior thesis paper about landfills and the importance of integrating them into the reduce, reuse, recycle mindset. They then talk about their experience as a chef on boats, and how they noticed the plastic waste that was being sent to landfills, sparking their interest in the plastic industry and waste management. The speaker then explains that their company, Serum, takes already recycled plastic and adds a biodegradable additive before turning it into single-use water bottles. This process creates a viable, valuable end of life solution for these plastics, while also helping to reduce plastic waste. The conversation discussed the process of what happens to food waste, plastic bottles, and other kinds of trash in a landfill. It is not the dump people have been told about for years, but a carefully engineered and managed space. As the waste decomposes, a methane gas is released and is now being captured and turned into renewable energy. This process of capturing methane from landfills is called the methane capture process and helps to reduce pollution and create a more circular economy. Additionally, the waste in the landfill breaks down within two to fifty years and helps to create energy instead of lingering in the environment. TIMESTAMPS 0:00:00 Interview with Kahl Wightman, Founder of Serum 0:02:23 Conversation with Kahle, a 24-Year-Old Chef Working on Super Yachts and Passionate About Plastics and Landfill Gas to Energy 0:04:09 Heading: Exploring the Benefits of Landfill Gas to Energy with Serum Founder, Chef-Turned-Entrepreneur, Sarah Koehler 0:10:11 "The Benefits of Landfill Management and Methane Capture" 0:12:05 "Exploring the Benefits of Waste-to-Energy: Turning Landfill Methane into Natural Gas" 0:16:01 Heading: Exploring the Benefits of Waste-to-Energy Technology for Packaging Circularity 0:18:01 Interview with Serum Co-Founder, Ryan Schoenfeld, on Biodegradable Plastics 0:22:07 Interview with Kale Kahle of Serum Water: Exploring Innovative Solutions to Waste Management HIGHLIGHTS Yeah, I love it. Let's kind of pull it back here to Serum. I know you said you're starting with water bottles, but are you seeing this be able to grow where packaging can be contributing at the end of it? Like, you talked about how you're using PCR materials where now packaging is not only contributing to sort of the circularity that comes from recycling, but now also contributing back into the circularity that can come from waste to energy. I completely agree. Yeah. And I think people going and saying when their argument against this technology is saying, well, natural gas has its own issues, it's just like saying, well, landfills, it's like demonizing the word landfill, demonizing the word natural gas, and nothing comes close to the capture rate that landfills have when it comes to consumer behavior. If the fact of the matter is 95% of our waste is going to these landfills.. And right now the fight is everyone's saying, let's change that, let's change that, let's push this waste out of that environment. But if we just embraced that and said, okay, let's roll with that, that's an amazing capture rate. Landfills aren't horrible entities. Let's roll with this and see if we can turn this into a positive thing. We'd make incredible progress in both clean energy and waste management. Yeah. And thinking about that and natural gas probably has its own opponents and all that stuff, right? But it's like, if we can create natural gas from our natural habits instead of our natural habitats through drilling and fracking and all that stuff, I got to imagine and I have zero idea what the proportionality is, right? Somebody might come in and be like, well, our landfills can only create less than 1% of the natural gas. Okay, I don't know these things. That's just not the reality of waste management. In the year 2023, landfills are meticulously engineered, they're highly managed. And most importantly, basically, when the waste is in the landfill, it's putting off a methane gas as it decomposes. And now these landfills are capped. And the methane gas, instead of becoming a pollutant, is now turned into basically clean, renewable energy. It's turned into natural gas. And not only that, but it's a baseload energy source. It's constantly emitting methane, unlike wind and solar, where sometimes there's not wind, sometimes there's not sun, there's always going to be methane coming out of a landfill. Coca Cola is not doing it, Nestle is not doing it and it hasn't been combined with using already recycled plastics. So with serum we take already recycled plastic. That plastics can only be recycled a number of times. We're just kind of trying to find a viable, valuable end of life solution for these plastics. We take the recycled plastic, we add the biodegradable additive, the landfill biodegradable additive and then we turn it into whatever plastic application we'd be focused on. Get full access to Packaging Is Awesome with Adam Peek at www.packagingisawesome.com/subscribe

Welcome to the Intimacy Advisor Podcast, Dr. Megan Fleming! In this episode, Dr. Megan Fleming joins us to take a look at a new lubricant, Beloved, created for comfort with nourishing and balancing ingredients that we should look for in a good intimate serum as a tool to our love-making toolbox.  Check out Beloved at Lover's Lane here! Read more about Dr. Megan Fleming here!See omnystudio.com/listener for privacy information.

Vote now in Mamamia's You Beauty Awards! This week Leigh tries a (wait for it)... $330 SERUM!  She explains why on earth a serum might cost that much and if it's worth it.  This week we found a savey foundation that's recommended by makeup artists and Kelly tries the world first 2 in 1 straightener and blow dryer.  THE END BITS Subscribe to Mamamia All the amazing products mentioned in today's episode can be found below:  SPENDY:  Leigh: Smooth Sip Lightweight Smoothing Moisturiser For Pores, $69 Kelly: GHD Duet, $595 SAVEY: Leigh: Innoxa Anti-Redness Foundation, $36.95 Kelly: QV Night Cream,$22.99 SHOP MY STASH:  Leigh: Bioeffect EGF Power Serum, $330 Kelly: Dermal Therapy Anti Itch Cream, $14.99 GET IN TOUCH: Got a beauty question you want answered?  Email us at youbeauty@mamamia.com.au or call the podphone on 02 8999 9386.  Join our You Beauty Facebook Group here. Want this and other podcasts delivered straight to your inbox? Subscribe to our podcast newsletter. You Beauty is a podcast by Mamamia. Listen to more Mamamia podcasts here. CREDITS: Hosts: Leigh Campbell & Kelly McCarren Producer: Mikayla Floriano Audio Producer: Leah Porges Mamamia acknowledges the Traditional Owners of the Land we have recorded this podcast on, the Gadigal people of the Eora Nation. We pay our respects to their Elders past and present, and extend that respect to all Aboriginal and Torres Strait Islander cultures. Just by reading our articles or listening to our podcasts, you're helping to fund girls in schools in some of the most disadvantaged countries in the world - through our partnership with Room to Read. We're currently funding 300 girls in school every day and our aim is to get to 1,000. Find out more about Mamamia at mamamia.com.auBecome a Mamamia subscriber: https://www.mamamia.com.au/subscribeSee omnystudio.com/listener for privacy information.

For the March 2023 edition of the V Podcast, Bryan delves into the world of Philly Blunt. Tracks new and old from the likes of Serum, Dillinja, The Sauce, Firefox, Randall and Myth. As always you can email your thoughts or shoutouts to podcast@vrecordings.com 01. L-Side and BCee - Crossroads feat Charlotte Haining 02. Beat Merchants - Mystical Energy feat Dan-I 03. Genesis Elijah - Undeniable (Command Strange Remix) 04. Command Strange - Obsession 05. A-Audio - Lock and Load feat Ilmatika 06. A-Audio - Highway feat Parly B 07. L-Side - Gimmie Back 08. Skuff and Illmatika - With You (Sl8r Remix) 09. Sl8r - Up Late 10. Miguel - Sure Ting (Villem Remix) 11. L-Side, Riya and Subten - Out of Control 12. Bluemode - Don?t Know 13. Fox and Break - Code Red 14. Fox and the Sauce - Yaga Yaga 15. Serum - Surrender 16. Paul T and Edward Oberon - Where Do We Go (Survival Remix) 17. London Electricity - Cum Dancing (Mozey Remix) 18. Carlito - Wide World 19. Carlito - Take Me Down 20. Critical Impact - Place to Hide 21. Heist - Harlots 22. Prolix - Lift Me Up (Benny L Remix) 23. Paul T and Edward Oberon - Rockin (L-Side Remix) 24. Drumsound and Bassline Smith - Pump It Up 25. Alibi - It?s All Good 26. Alibi and Sl8r - Tune 27. Level 2 - Bali Hai 28. Leviticus - Burial 29. Trinity (AKA Dillinja) - Gangsta 30. Trinity (AKA Dillinja) - I Selasse I 31. Dillinja - Sky 32. Dillinja - Mutha Fucka 33. Dillinja - Mutha Fucka (Firefox Remix) 34. Firefox - Check Da Skillz 35. Firefox and Survivor - Who is It 36. Glamour Gold and Firefox - Bass Switch 37. Firefox and Survivor - Back Out Ah Dis 38. Glamour Gold - You Can Run 39. Glamour Gold - Now I Got to Show You 40. Firefox - Your Heart 41. Firefox and 4 Tree - Warning 42. Firefox - Bonanza Kid 43. Firefox - Buck Rodgers 44. Randall - Bionic R 45. Melinki - Radical Sounds 46. DJ Andy - D Light 47. Minor Forms - Times Tickin (Myth Remix) 48. Watch Da Ride - No Reason (Myth Remix) 49. Level 2 - Purple Haze

Welcome to season 4 of the podcast! This season we are focusing on minerals. How to test them, what the different minerals do in our bodies, how they impact our hormones and overall health as well as other systems of the body. We also have some exciting podcast updates. You heard me mention a podcast Patreon in the introduction. You may be thinking, what patreon? The AYM podcast patreon is new! I started it in February as a way to bring the podcast community together and provide more resources to support listeners on their healing journeys. You will still get your weekly episode of the podcast, but it will be a bit shorter (hopefully) and easier to digest. Each week, patrons get a bonus episode of the podcast along with downloadable resources. For example, in this episode I'm focusing on how to test minerals and what different types of tests tell you.  The bonus episode is a results review of a hair test and blood work to help bring all the principles of the episode together. The downloadable resource is a PDF of the main principles of mineral testing and lab testing resources. When the podcast isn't in season, I am creating content based off monthly surveys to ensure I'm giving members the resources they need. This tier is $10. I also have an exclusive tier that is $20 a month and allows you to submit a voicemail question that I answer during a pre-recorded Q&A. Visit patreon.com/hormonehealingrd to learn more and become a patron!Links/Resources:Patreon: https://www.patreon.com/hormonehealingrd Mineral Quiz: https://quiz.tryinteract.com/#/63fcdeb0284142001410c683  Mineral Training: https://bit.ly/38BteSF Feminine Periodical (monthly newsletter): https://hormonehealingrd.ck.page/d0317056cd  Iodine Podcast Episode: https://podcasts.apple.com/us/podcast/iodine-the-miracle-mineral/id1568547321?i=1000560008653 Metabolic Type Episode: https://podcasts.apple.com/us/podcast/understanding-metabolic-type-on-an-htma/id1568547321?i=1000527836892 Macro Minerals Episode: https://podcasts.apple.com/us/podcast/minerals-101/id1568547321?i=1000527073902 Research Articles: The issue with blood labs:Serum magnesium example: https://pubmed.ncbi.nlm.nih.gov/20170394/ Iodine Urine Testing: https://www.optimox.com/content/Iodine%20Research%20Resources/IOD17.pdf Optimal levels of iodine: http://www.medicinacomplementar.com.br/biblioteca/pdfs/Nutrientes/nu-0191.pdf All iodine research articles from Hakala Labs: https://www.hakalalabs.com/Research_ep_41.html HTMA Accuracy & Comparison to Blood:https://www.ncbi.nlm

We're all over the show today! From discovering who in our family gets a turn down service every damn day, to miracle snail serum on amazon and a gory story to finish - we're catching up and sharing our latest favourite things.  As always, if you want to hang out with us some more and support the running of the podcast, feel free to check out our Patreon page here. It's just $5 a month to access our BTS and come along to our patron only events! https://www.patreon.com/makinganeffortpodcast

01. Fred V - Freefall (feat. Hamzaa) 02. Armand Van Helden, Karen Harding - Wings (I Won't Let You Down) [Krakota Remix] 03. Maykors - You Know Why 04. Sub;Liminal & Resurgence - Just A Waste Vip 05. Camo & Krooked, Mira Lu Kovacs - No Way Out (Ragemode Remix) 06. Clank & Maider - You Make Me Feel 07. Nct - There For U 08. Elder - Scream 09. Elder - Love 10. Rueben, Phi Nix - In My Mind 11. Azumai - Ah Eh 12. Osprey - Lorem Ipsum 13. Alya Dey - Без Тебя (Gancher & Ruin Remix) 14. Akuma - Change (Eskr Remix) 15. Aznok, Gilas - Caravan 16. Paperclip & Dextems - Tutorium 17. Burr Oak - Ring The Death Knell 18. Dextems-Monovalent 19. M@Shinist - The Same As Everyone [Basseffect] 20. Droeloe X Imanu - Catalyst 21. Michael Kruzh - Wow [Basseffect] 22. Maltes - Makhtesh 23. Jakzman - Deeper 24. Villainy - The Launch(Trei Remix) 25. Phase - Unsu 26. Dizrupt - Rackle 27. Nodsy - Face2Face 28. 3Id - Chemsitry 29. Petarda - 2Suns 30. Sub;Liminal & Kvr - Scenes From A Memory 31. Turno, Tominthechamber, Haribo - Triad 32. Sustance - Magnetic 33. Tone Walsh - Meanings 34. Sequences/Slippy Skills - The Prophecy 35. Inja, Dj Limited - Fall Down On Me 36. Doktor - Why You Waiting? (feat. Serum & Agent Sasco) 37. Bassface Sascha, Feindsoul - Back To Basics 38. Natty Lou - All For You feat. Dolly Rae 39. Phase - Code Of Honour 40. Leks - Collar Him 41. Pola & Bryson & Emily Makis - Phoneline 42. Mvrk, Ential - Self-Love 43. Teej, Trex, Medic Mc - Hot One (T>I Remix) 44. Roll97 - Gunstore 45. Entita, Glyph - Wallbreaker 46. Slix - Elm Street 47. Sin Buzz - Rap [Your Bass Busters Dub] 48. Infrared - Guns 49. Pruf - Ritual (F*Ck Glam Dub) 50. Basshunterz - Get Ready 51. Alex Slk, Teej - Waves 52. Blade - Go Away (Drowning Pain) 53. Taelimb - Ragged 54. Arcane - Mash Up Da Place 55. Entropy & Guzi - Backspin 56. Rumble, Parly B - In The Dancehall (Chatta B & Londub Remix) 57. Erbass - A Thought 58. Sl8R, Samurai Breaks, Mnt - Manny Ravers 59. Andrey Hot - Last Year's Snow 60. Thing - Got Any Jungle, Mate ? 61. Janaway - 24-7 Soundclash 62. Enjoy & Woken Balance - State Of Existence 63. Ноггано feat. Qп - Оп Давай Давай (Da.Lab Censored Remix) 64. Physics - Fly Away 65. Soul Connection - U Doing Me Like That 66. Bill & Ed - So Weak 67. Subjective, Lameduza - Paradise (Goldie & Submotive Remix) 68. Msdos - Ideal Night 69. Near Edge - Lighthouse 70. Matt View - Near Me 71. Echomatics - Riddle Me This 72. Incident, Moodular - So Many Places 73. Thirteenth Output - New Hairstyle 74. Son, Chamba - Gaia 75. M-Acid - Fading Pictures 76. Thirteenth Output - Peter Metro 77. Sine Conflict - Key

In this best of series interview, Dr. Joseph Mercola, natural health expert, and Gerry Koenig, former chairman of the Iron Disorders Institute and the Hemochromatosis Foundation, explain the value of monitoring your serum ferritin and GGT levels.

We take a Pre-operative study from the Annals of Surgery and talk about perioperative risk management for patients with low serum creatinine.

Recorded 2023-02-14 02:00:11 DnB Radio Tracklisting: * Vodkah - Severance (Original Mix)* Dip Vertigo - Exhale (Original Mix)* Calyx & TeeBee - Elevate This Sound * A Sides - One DJ 2016* Azpect ft G1 - Next Step djss remix* MONSS - On Your Mind (Original Mix)* Dash - Dreams (Original Mix) broken* Doktor, Document One - Okay (Original Mix)* The Vanguard Project - Sticky (Original Mix)* Lateral - Chasing The Sun (feat. Aleya Mae) (Extended Mix)* A Sides - Temptation (Feat Makoto)* Blade - You Can't Fix This (Original Mix)* Wez Walker - Looking In (HK Sage Remix)* Artificial Intelligence - Desperado (Original Mix)* Dawn Wall - Movies (Original Mix)* Nu:Tone - Shelter (feat. DJ Rae)* Decon - Washington (Original Mix)* A Sides - Stay* A:D - Light In My Soul (Original Mix)* Artificial Intelligence, Drs - Isolate (feat. DRS) (Original Mix)* Moko, Kove - Hurts (LSB Remix) * Onside - True* Pola & Bryson, Emily Makis - Phoneline (Original Mix)* Vodkah, Dr Khan - Embrace (Original Mix)* 4K - Peace Of Mind (Original Mix)* COMA, DLR, Arkaik, ray uptown - Mindgames (DLR Remix)* Doktor - Why You Waiting? (feat. Serum & Agent Sasco)* GABRIEL - Overgrown* Black Sun Empire, Prolix, Enei - The Message (Enei Remix)* Koherent - Dancing Soul (Original Mix)* Prolix, Coppa, V O E - Subterranean (V O E Remix)* Mojay - Back Again Dub (Aktive Remix)* Skibadee, Jakes, Critical Impact, Carasel - Headbanger (Original Mix)* Dirtyphonics - Run (Original Mix)* Metrik - Utopia* Zeal, Coppa, Raiser - Pipebomb (Original Mix)* Rene Lavice, Raign - Fall From The Dark (Extended Mix)* S.P.Y, Maduk - Still In Love (S.P.Y Remix)* Document One, Emily Makis - Tongue Tied (Original Mix)* Polaris - Alignment* Keeno x Polaris - Leviathan * The Vanguard Project - Isolation Station (Original Mix) * Calibre, Drs, Tyler Daley - I Remember (Original Mix)* Artificial Intelligence - Scratch the Surface (Original Mix)* Calibre - Moonlight (Original Mix)* High Contrast - Make It Tonight (High Contrast VIP Remix)* M.I.S.T. vs. High Contrast - 3am* MC Conrad, ConNatural - Lean Upwards feat. MC Conrad (Makoto Remix)* Macca, DJ Marky, Loz Contreras - Daktari (Original Mix)* DJ Marky, S.P.Y. - Yellow Shoes (Calibre Remix) * Dr. Apollo - Change feat. FiNNi * Dux N Bass - With You* Matrix & Futurebound - Control * Placid - Gravitation (Original Mix) * Dimension, Poppy Baskcomb - Where Do We Go (feat. Poppy Baskcomb) (Original Mix)* 5Kumarion & Slang Dogs - You Ain't Tough* Grafix - Alone (feat. Ruth Royall)* Grafix - Only Now* Grafix - Distressed* Grafix - Blue Dreams* Fred V & Grafix X Metrik - Tension (feat Kate Westall)* Wilkinson, Amber Van Day - Keep Dancing (Original Mix)* Mind Vortex - Impulse * Dub Elements, Flite - Abandoned (Original Mix)* Enei, odddi - Show Me (Original Mix)* VovKing - Kilohertz* High Contrast - Return Of Forever (Camo & Krooked & Mefjus Remix)* David Guetta, Lewis Thompson - Take Me Back (Pola & Bryson Remix)* Netsky - Memory Lane (Flava D Remix)* Netsky & Urbandawn - Power* Friction - Terabyte (Original mix)* Andy C - What Bass (Original Mix)* Andy C, Shimon - Night Flight (Shimon Remix)* D Bridge - True Romance (Original Mix) * Cabin Fever - Hard Goin* Siren - Snorkel (Original Mix)* S.P.Y - Warrior Dub * Commix - I Have You - Original Mix * Chase & Status, Liam Bailey - Blind Faith feat. Liam Bailey (Loadstar Remix) * Commix - Be True (Original Mix) * Un-Cut - Midnight (MIST Remix) Tracklisting:* Vodkah - Severance (Original Mix)* Dip Vertigo - Exhale (Original Mix)* Calyx & TeeBee - Elevate This Sound * A Sides - One DJ 2016* Azpect ft G1 - Next Step djss remix* MONSS - On Your Mind (Original Mix)* Dash - Dreams (Original Mix) broken* Doktor, Document One - Okay (Original Mix)* The Vanguard Project - Sticky (Original Mix)* Lateral - Chasing The Sun (feat. Aleya Mae) (Extended Mix)* A Sides - Temptation (Feat Makoto)* Blade - You Can't Fix This (Original Mix)* Wez Walker - Looking In (HK Sage Remix)* Artificial Intelligence - Desperado (Original Mix)* Dawn Wall - Movies (Original Mix)* Nu:Tone - Shelter (feat. DJ Rae)* Decon - Washington (Original Mix)* A Sides - Stay* A:D - Light In My Soul (Original Mix)* Artificial Intelligence, Drs - Isolate (feat. DRS) (Original Mix)* Moko, Kove - Hurts (LSB Remix) * Onside - True* Pola & Bryson, Emily Makis - Phoneline (Original Mix)* Vodkah, Dr Khan - Embrace (Original Mix)* 4K - Peace Of Mind (Original Mix)* COMA, DLR, Arkaik, ray uptown - Mindgames (DLR Remix)* Doktor - Why You Waiting? (feat. Serum & Agent Sasco)* GABRIEL - Overgrown* Black Sun Empire, Prolix, Enei - The Message (Enei Remix)* Koherent - Dancing Soul (Original Mix)* Prolix, Coppa, V O E - Subterranean (V O E Remix)* Mojay - Back Again Dub (Aktive Remix)* Skibadee, Jakes, Critical Impact, Carasel - Headbanger (Original Mix)* Dirtyphonics - Run (Original Mix)* Metrik - Utopia* Zeal, Coppa, Raiser - Pipebomb (Original Mix)* Rene Lavice, Raign - Fall From The Dark (Extended Mix)* S.P.Y, Maduk - Still In Love (S.P.Y Remix)* Document One, Emily Makis - Tongue Tied (Original Mix)* Polaris - Alignment* Keeno x Polaris - Leviathan * The Vanguard Project - Isolation Station (Original Mix) * Calibre, Drs, Tyler Daley - I Remember (Original Mix)* Artificial Intelligence - Scratch the Surface (Original Mix)* Calibre - Moonlight (Original Mix)* High Contrast - Make It Tonight (High Contrast VIP Remix)* M.I.S.T. vs. High Contrast - 3am* MC Conrad, ConNatural - Lean Upwards feat. MC Conrad (Makoto Remix)* Macca, DJ Marky, Loz Contreras - Daktari (Original Mix)* DJ Marky, S.P.Y. - Yellow Shoes (Calibre Remix) * Dr. Apollo - Change feat. FiNNi * Dux N Bass - With You* Matrix & Futurebound - Control * Placid - Gravitation (Original Mix) * Dimension, Poppy Baskcomb - Where Do We Go (feat. Poppy Baskcomb) (Original Mix)* 5Kumarion & Slang Dogs - You Ain't Tough* Grafix - Alone (feat. Ruth Royall)* Grafix - Only Now* Grafix - Distressed* Grafix - Blue Dreams* Fred V & Grafix X Metrik - Tension (feat Kate Westall)* Wilkinson, Amber Van Day - Keep Dancing (Original Mix)* Mind Vortex - Impulse * Dub Elements, Flite - Abandoned (Original Mix)* Enei, odddi - Show Me (Original Mix)* VovKing - Kilohertz* High Contrast - Return Of Forever (Camo & Krooked & Mefjus Remix)* David Guetta, Lewis Thompson - Take Me Back (Pola & Bryson Remix)* Netsky - Memory Lane (Flava D Remix)* Netsky & Urbandawn - Power* Friction - Terabyte (Original mix)* Andy C - What Bass (Original Mix)* Andy C, Shimon - Night Flight (Shimon Remix)* D Bridge - True Romance (Original Mix) * Cabin Fever - Hard Goin* Siren - Snorkel (Original Mix)* S.P.Y - Warrior Dub * Commix - I Have You - Original Mix * Chase & Status, Liam Bailey - Blind Faith feat. Liam Bailey (Loadstar Remix) * Commix - Be True (Original Mix) * Un-Cut - Midnight (MIST Remix) Download, Distribute, and Donate!

For the 139th edition of the V Podcast, Bryan rolls out for a mammoth 2 hour and 20 minutes. New music from the likes of LSB, Break, Motiv, Command Strange, Watch The Ride and many more. This months spotlight focuses on the early works of Krust, Roni Size, DJ Die and Suv. As always you can email your thoughts or shoutouts to podcast@vrecordings.com 01. Motiv - Done for Me ft. Luke Truth 02. Motiv - Manny Made the Music ft. Slay and J Ken 03. Sl8r and J Ken - Light Traveller 04. Beat Merchants and Dan I - Mystical 05. Mozey - Missing Calls ft. Catching Cairo 06. L-Side, Riya and Subten - Out of Control 07. Unkoded - Too Late ft. Hannah Collins 08. L-Side - Old Days 09. Motiv - Cloak and Dagger ft. Collette Warren (Random Movement Remix) 10. A-Audio - When We Get Together 11. Whiney - Rock Up Da Vibe (Instrumental Mix) 12. High Contrast - Cant Give You Up 13. Genesis Elijah - Undeniable (Command Strange Remix) 14. LSB - High as She ft. DRS (Break Remix) 15. Break - Bury a Sound 16. Level 2 - Bali Hai 17. Alibi and A-Audio - Middle Men 18. Black Barrel - Fabric (DLR Remix) 19. London Electricity - Billion Dollar Gravy (Watch the Ride Remix) 20. Command Strange - Obsession 21. Alibi and Sl8r - Tune 22. Alibi - Bad Trip VIP 23. Particle - Fall 2 Fast (Skeptical Remix) 24. Paul T and Edward Oberon - Wake Up ft. A Little Sound (Phibes Remix) 25. A-Audio - The Soldier 26. Carlito - Got It 27. The Deceivers (AKA DJ Krust) - Darkness Becomes You 28. Roni Size - The Refresher 29. Roni Size - Kutt 30. DJ Die - Jigsaw 31. Suv - Everyone Plays the Same 32. Suv - V Beat 33. Roni Size - Step Up 34. Firefox and Survivor - Turbulence 35. Die and Suv - Out of Sight 36. Krust - Doin Our Thing 37. Krust - Untitled Dub 38. Drumsound and Bassline Smith - Undrground Warriors 39. Prolix - Lift Me Up (Benny L Remix) 40. Benny L and Jappa - ID ft. Ragga Twins 41. Inja, Fats and Whiney - Eyes on You 42. Break - Gunshot Love ft. Liam Bailey 43. Paul T and Edward Oberon - Rockin Me (L-Side Remix) 44. Alibi - Its All Good 45. Level 2 - Purple Haze 46. Clipz - Shorty 47. Acuna - Break Through 48. Heist - Camoflauge feat. MC Funsta

February 1, 1925. After a diphtheria outbreak threatens to decimate the entire icebound community of Nome, Alaska, a five-day dog sled relay to carry life-saving medicine finally arrives in the isolated town.Go to HistoryDaily.com for more history, daily.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The Filtrate:Joel TopfSwapnil HiremathJordy Cohen With Special Guest:Laurie Tomlinson. @Roxytonin Nephrologist at University Hospitals Sussex and research hero of Jordy. Editor: Priya Yenebere Show Notes:STOP-ACE in pubmed: Renin-Angiotensin System Inhibition in Advanced Chronic Kidney DiseaseSTOP-ACE Summary in NephJC Prior data showing preservation of renal function by stopping ACEi: The impact of stopping inhibitors of the renin-angiotensin system in patients with advanced chronic kidney diseaseEfficacy and Safety of Benazepril for Advanced Chronic Renal Insufficiency: NEJMDr. Tomlinson's article on creatinine changes in RASi from 2017: Serum creatinine elevation after renin-angiotensin system blockade and long term cardiorenal risks: cohort study NephJC | PubMed Accuracy of eGFR at low GFR: A new equation to estimate glomerular filtration rateStrong opinions, loosely held. “Permissive AKI” with treatment of heart failure. Editorial by Chirag Parish and Steven CocaThe rational for NICE avoiding RASi in black patients: Hypertension and ethnic groupAASK trial showing superiority of RASi in African Americans. JAMAALLHAT post-hoc analysis of outcomes by self-reported race. JAMA | PubMedSophisticated Swedish observational study that Swap loved. Stopping Renin-Angiotensin System Inhibitors in Patients with Advanced CKD and Risk of Adverse Outcomes: A Nationwide StudyTarget Trials in Nephrology Dr Edouard Fu grand rounds at Ottawa Nephrology, YouTubeTarget Trial EmulationA Framework for Causal Inference From Observational Data by Miguel Hernán in JAMATubular SecretionsJordy: Third season of His Dark Materials on HBOSwap: Movies by Wes Anderson on Disney PlusLaurie: The Book, “Nearly All the Men in Lagos are Mad”Jordy: How Medicine Works and When It Doesn't: Learning Who to Trust to Get and Stay Healthy | AmazonJoel EO | NYT Review

Dr. Gary Davis, an Ivy League-trained Black physician from Tulsa, Oklahoma, had a literal dream that the cure for AIDS would come from a goat. In the new podcast Serum, a reporting team at WHYY and Local Trance Media delve into the unusual story of a Davis' quest to develop the cure. At the height of the AIDS epidemic in the early '90s, Davis derived a serum from goat blood that he believed could help cure HIV, the virus that causes AIDS. He brought his research to the FDA to start a clinical trial – but just hours before it was supposed to start, it was shut down. Davis had powerful critics and ardent supporters. Some sued in court to be allowed to try Davis' treatment, while others chose to ask for forgiveness rather than permission to get their hands on it. What was the true potential of Davis' serum – and who are the people who say it saved their lives? Support Reveal's journalism at Revealnews.org/donatenow Subscribe to our weekly newsletter to get the scoop on new episodes at Revealnews.org/weekly Connect with us on Twitter, Facebook and Instagram

In this episode, I discuss the difference between overeating and binge eating. I discuss tips for helping binge eating habits, as well as how to stop your mind from being consumed by thiniking about food all the time. I also share a few helpful pieces of advice to have a success school semester!    Sk's Diamond Recs:  Soma PJ's: https://www.soma.com/store/product/Cool-Nights-Tassel-Ankle-Pajama-Pants/570318464?color=4646&size=5181&CMP=csc_goog_pla&utm_content=autoag0000x18815565838&gclid=Cj0KCQiAq5meBhCyARIsAJrtdr7chy6ykWhiv6sntaf-ncEmOI_KoSYGkzvjlQQfflfZZQCeJRcIOz0aAlAHEALw_wcB  Dr. Jart Products:  Mask: https://www.drjart.com/product/28256/101183/masks/pore-remedytm-purifying-mud-mask  Serum: https://www.drjart.com/product/28259/101182/serums/pore-remedytm-pha-exfoliating-serum?gclid=Cj0KCQiAq5meBhCyARIsAJrtdr4Xi6SN5gbix9kveApXbCDXnM-JQw5-6cX7516G506V0VXtIyQLtu8aAgu0EALw_wcB&gclsrc=aw.ds    Patrick Ta Contour and Bronzer Duo:  https://www.sephora.com/product/patrick-ta-major-sculpt-creme-contour-powder-bronzer-duo-P471059?country_switch=us&lang=en&skuId=2419356&om_mmc=ppc-GG_18529539267_142939699835_pla-1816514636523_2419356_626820665501_9010437_c&gclid=Cj0KCQiAq5meBhCyARIsAJrtdr5w58VRDpYUErn2PggWtfMIZIVoyTU6u7dUu1Np1seTUcQyl6qN6PAaAh4YEALw_wcB&gclsrc=aw.ds 

Roger Seheult, MD of MedCram explains the association between high serum sodium levels and mortality and chronic disease. See all Dr. Seheult's videos at: https://www.medcram.com (This video was recorded on January 16, 2023) Roger Seheult, MD is the co-founder and lead professor at https://www.medcram.com He is Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine and an Associate Professor at the University of California, Riverside School of Medicine. MEDCRAM WORKS WITH MEDICAL PROGRAMS AND HOSPITALS: MedCram offers group discounts for students and medical programs, hospitals, and other institutions. Contact us at customers@medcram.com if you are interested. MEDIA CONTACT: Media Contact: customers@medcram.com Media contact info: https://www.medcram.com/pages/media-contact Video Produced by Kyle Allred FOLLOW US ON SOCIAL MEDIA: https://www.facebook.com/MedCram https://twitter.com/MedCramVideos https://www.instagram.com/medcram DISCLAIMER: MedCram medical videos are for medical education and exam preparation, and NOT intended to replace recommendations from your doctor. #water #serum #sodium

In this episode, I discuss the importance and limitations of Serum creatinine and creatinine clearance for renal function assessment.

Videos : Proof Government Lab Created COVID, Says Escaped Chinese Virologist Dr. Li-Meng Yan – Ask Dr. Drew   Fewer cases of melanoma among people taking vitamin D supplements University of Eastern Finland, January 10, 2023 Fewer cases of melanoma were observed among regular users of vitamin D supplements than among non-users, a new study finds. People taking vitamin D supplements regularly also had a considerably lower risk of skin cancer, according to estimates by experienced dermatologists. The study, conducted in collaboration between the University of Eastern Finland and Kuopio University Hospital and published in Melanoma Research, included nearly 500 people with an increased risk of skin cancer. 498 adult patients estimated to have an increased risk of a skin cancer, such as basal cell carcinoma, squamous cell carcinoma or melanoma, were recruited at the dermatological outpatient clinic of Kuopio University Hospital. Experienced dermatologists at the University of Eastern Finland carefully analysed the patients' background information and medical history and examined their skin. The dermatologists also classified the patients into different skin cancer risk classes, namely low risk, moderate risk and high risk. Based on their use of oral vitamin D supplements, the patients were divided into three groups: non-users, occasional users and regular users. Serum calcidiol levels were analysed in half of the patients and found to correspond to their self-reported use of vitamin D. A key finding of the study is that there were considerably fewer cases of melanoma among regular users of vitamin D than among non-users, and that the skin cancer risk classification of regular users was considerably better than non-users'. Logistic regression analysis showed that the risk for melanoma among regular users was considerably reduced, more than halved, compared to non-users. The findings suggest that even occasional users of vitamin D may have a lower risk for melanoma than non-users. Other relatively recent studies, too, have provided evidence of the benefits of vitamin D in melanoma, such as of the association of vitamin D with a less aggressive melanoma. (NEXT) Diabetics should pay attention to vitamin C University of Otago (New Zealand), January 9 2023. Research reported in Nutrients suggests that low intake and serum levels of vitamin C may be particularly risky for adults with diabetes. The study analyzed data from 25,206 men and 26,944 women who participated in the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2018. Four hundred twenty-eight individuals had type 1 diabetes and 6,807 had type 2 diabetes. At the beginning of the study, 38% of the people had an intake of vitamin C that was below the estimated average requirement (EAR), which worsened to 46.5% by 2017-2018. Individuals whose intake of vitamin C was lower than the EAR had a 20% higher risk of type 2 diabetes compared with an intake above the EAR, and those who did not use vitamin C supplements had a 28% greater risk than vitamin C supplement users. Low and deficient serum vitamin C levels were associated with fewer years of life in comparison with normal vitamin levels. Compared with an adequate intake of vitamin C, the risk of mortality through 2019 among type 2 diabetics was 25% greater for those with a very low intake of the vitamin. Deficient serum levels of the vitamin were associated with an 84% greater mortality risk compared with adequate levels. Not supplementing with vitamin C was associated with a 25% greater mortality risk among people with type 1 diabetes, a 20% greater risk among those with type 2 diabetes and a 24% greater risk among nondiabetics compared with supplementation. “Observation of declining vitamin C intake and deleterious consequences of low serum vitamin C in US adults with diabetes suggests encouragement of vitamin C intake, including vitamin C supplementation of 500–1000 mg/day, may be beneficial for pre-diabetic and diabetic US adults,” the authors concluded. (NEXT) Feeling depressed? Performing acts of kindness may help Ohio State University, January 10, 2023 People suffering from symptoms of depression or anxiety may help heal themselves by doing good deeds for others, new research shows. The study found that performing acts of kindness led to improvements not seen in two other therapeutic techniques used to treat depression or anxiety. Most importantly, the acts of kindness technique was the only intervention tested that helped people feel more connected to others, said study co-author David Cregg at The Ohio State University. “Social connection is one of the ingredients of life most strongly associated with well-being. Performing acts of kindness seems to be one of the best ways to promote those connections,” Cregg said. The research also revealed why performing acts of kindness worked so well: It helped people take their minds off their own depression and anxiety symptoms. This finding suggests that one intuition many people have about people with depression may be wrong, Cheavens said. “We often think that people with depression have enough to deal with, so we don't want to burden them by asking them to help others. But these results run counter to that,” she said. “Doing nice things for people and focusing on the needs of others may actually help people with depression and anxiety feel better about themselves.” The study involved 122 people in central Ohio who had moderate to severe symptoms of depression, anxiety, and stress. After an introductory session, the participants were split into three groups. Two of the groups were assigned to techniques often used in cognitive behavioral therapy (CBT) for depression: planning social activities or cognitive reappraisal. Members of the third group were instructed to perform three acts of kindness a day for two days out of the week. Acts of kindness were defined as “big or small acts that benefit others or make others happy, typically at some cost to you in terms of time or resources.” Some of the acts of kindness that participants later said they did included baking cookies for friends, offering to give a friend a ride, and leaving sticky notes for roommates with words of encouragement. Participants followed their instructions for five weeks, after which they were evaluated again. The researchers then checked with the participants after another five weeks to see if the interventions were still effective. The findings showed that participants in all three groups showed an increase in life satisfaction and a reduction of depression and anxiety symptoms after the 10 weeks of the study. “But acts of kindness still showed an advantage over both social activities and cognitive reappraisal by making people feel more connected to other people, which is an important part of well-being,” he said. In addition, the acts of kindness group showed greater improvements than the cognitive reappraisal group for life satisfaction and symptoms of depression and anxiety, results showed. Cheavens noted that just participating in social activities did not improve feelings of social connection in this study. “There's something specific about performing acts of kindness that makes people feel connected to others. It's not enough to just be around other people, participating in social activities,” she said. (NEXT) Selenium protects a specific type of interneurons in the brain Helmholtz Zentrum München (Germany) December 29, 2022 Exactly 200 years ago, the Swedish scientist Jöns Jacob Berzelius discovered the trace element selenium, which he named after the goddess of the moon, Selene. Selenium is an essential trace element and indispensable for humans, many animals and some bacteria. A team led by Dr. Marcus Conrad, research group leader at the Institute of Developmental Genetics (IDG) at Helmholtz Zentrum München, showed for the first time why selenium is a limiting factor for mammals. The scientists have been investigating for years the processes of a novel type of cell death, known as ferroptosis. In this context, the enzyme GPX4, which normally contains selenium in the form of the amino acid selenocysteine, plays an important role. In order to better understand the role of GPX4 in this death process, we established and studied mouse models in which the enzyme was modified,” said study leader Conrad. “In one of these models, we observed that mice with a replacement of selenium to sulfur in GPX4 did not survive for longer than three weeks due to neurological complications.” In their search for the underlying reasons, the researchers identified a distinct subpopulation of specialized neurons in the brain, which were absent when selenium-containing GPX4 was lacking. “In further studies, we were able to show that these neurons were lost during postnatal development, when sulfur- instead of selenium-containing GPX4 was present,” stated first author of the study, Irina Ingold. Furthermore, the scientists were able to show that ferroptosis is triggered by oxidative stress, which is known to occur for instance during high metabolic activity of cells and high neuronal activity. “Our study demonstrates for the first time that selenium is an essential factor for the postnatal development of a specific type of interneurons,” said Dr. José Pedro Friedmann Angeli, a scientist at the IDG, describing the results. “Selenium-containing GPX4 protects these specialized neurons from oxidative stress and from ferroptotic cell death.” (NEXT) Association of Dietary α-Carotene and β-Carotene Intake with Low Cognitive Performance in Older Adults Sun Yat-sen University (China), January 3, 2023 With the increased life expectancy around the world, the number of elderly people with cognitive decline has been escalating, causing a burden for their families and governments. The decline in cognitive function is associated with various factors, including normal aging processes and neurological diseases. However, without any prevention measures to delay cognitive function decline, the decline in cognitive function will gradually develop into mild cognitive impairment (MCI) and Alzheimer's disease. The process of Alzheimer's disease is irreversible, and medical treatment for this disease is still limited. The underlying mechanism of vitamin B12 on cognitive function is related to the activation of methylation reactions in the brain. According to previous studies, vitamin A, an antioxidant in the central nervous system, also participates in cognitive function decline in older people. Both α-carotene and β-carotene can be transformed into retinol, which will be converted into a long-chain fatty acid ester that is the main precursor of vitamin A in the human body. Thus, α-carotene and β-carotene may have similar effects on neurocognitive decline. Some previous studies showed that higher levels of α-carotene and β-carotene in the plasma were associated with better cognitive function. In this study, our results reflected that dietary α-carotene and β-carotene intake might have inverse effects on cognitive function decline in older people. However, the excessive intake of dietary α-carotene and β-carotene may be a problem that needs special attention. (NEXT) Consumption of fast food linked to liver disease University of Southern California, January 10, 2023 The new year has begun, and with it, resolutions for change. A study from Keck Medicine of USC published in Clinical Gastroenterology and Hepatology gives people extra motivation to reduce fast-food consumption. The study found that eating fast food is associated with nonalcoholic fatty liver disease, a potentially life-threatening condition in which fat builds up in the liver. Researchers discovered that people with obesity or diabetes who consume 20% or more of their daily calories from fast food have severely elevated levels of fat in their liver compared to those who consume less or no fast food. And the general population has moderate increases of liver fat when one-fifth or more of their diet is fast food. “Healthy livers contain a small amount of fat, usually less than 5%, and even a moderate increase in fat can lead to nonalcoholic fatty liver disease,” said Ani Kardashian, MD, a hepatologist with Keck Medicine and lead author of the study. “The severe rise in liver fat in those with obesity or diabetes is especially striking, and probably due to the fact that these conditions cause a greater susceptibility for fat to build up in the liver.” The findings also reveal that a relatively modest amount of fast food, which is high in carbohydrates and fat, can hurt the liver. “If people eat one meal a day at a fast-food restaurant, they may think they aren't doing harm,” said Kardashian. “However, if that one meal equals at least one-fifth of their daily calories, they are putting their livers at risk.” Nonalcoholic fatty liver disease, also known as liver steatosis, can lead to cirrhosis, or scarring of the liver, which can cause liver cancer or failure. Liver steatosis affects over 30% of the U.S. population. The study characterized fast food as meals, including pizza, from either a drive-through restaurant or one without wait staff. The researchers evaluated the fatty liver measurement of approximately 4,000 adults whose fatty liver measurements were included in the survey and compared these measurements to their fast-food consumption. Of those surveyed, 52% consumed some fast food. Of these, 29% consumed one-fifth or more daily calories from fast food. Only this 29% of survey subjects experienced a rise in liver fat levels. The association between liver steatosis and a 20% diet of fast food held steady for both the general population and those with obesity or diabetes even after data was adjusted for multiple other factors such as age, sex, race, ethnicity, alcohol use and physical activity.

Starting 2023 the right way, with a brand new instalment of the V Podcast. Bryan steps up with over two hours of new, unheard music from the likes of L-Side, Break and Liam Bailey, Sl8r, A-Audio and Syren Rivers, Carlito, and lots, lots more. For this months spotlight we take a look at some of the best tracks from one of the V Recordings originators; Roni Size. As always you can email your thoughts or shoutouts to podcast@vrecordings.com 01. Beat Merchants - Good Time 02. A-Audio and Syren Rivers - In My Veins 03. Genesis Elijah - Undeniable (Command Strange Remix) 04. Carlito and T.R.A.C. - On My Mind 05. Motiv - Fever Dream 06. Sl8r and Motiv - To Me 07. Sl8r - Homegrown 08. Lynx - Under the Stars (L-Side Remix) 09. Break and Liam Bailey - Gotta Believe 10. No Guidance - Make Me Wanna 11. Gardna and MC Skibbadee - Every Time I Land 12. Gardna and DRS - R.A.V.E A.S.A.P 13. Sl8r and Samauri Breaks - Manny Ravers 14. Drumsound and Bassline Smith - Jungle Dub (Here It Comes) 15. Bladerunner - Rave Machine 16. Paul T and Edward Oberon - Music's Got Soul ft. Cleveland Watkiss (Benny L Remix) 17. Heist - Jus Called 18. Randall - Make It Happen 19. Heist and MC Funsta - Rob Da Bank 20. Carlito - Take Me Down 21. Makoto and MC Conrad - Golden Girl 22. Roni Size and DJ Die - All the Way 23. Roni Size and DJ Die - The Calling 24. Roni Size - Agility 25. Roni Size - Fresh 26. Roni Size - Its a Jazz Thing 27. L-Side - Twisted 28. Voltage, Chimpo and Salo - Reebok Classic 29. L-Side and Riya - Out of Control 30. Breakage - Most High 31. Voltage - Scorpion 32. T>I - Bring It 33. Level 2 and L-Side - How It Is 34. Level 2 and Acuna - Heavy Drop 35. Terrorist - Diligent Fingers 36. Break and Fox - Code Red 37. The Sauce and Fox - Yagga Yagga 38. Level 2 - Purple Haze 39. Sheena - Burning Up 40. Command Strange - Obsession 41. A-Audio and Unkoded - Dip Out 42. A-Audio and Illmatika - Lock and Load 43. Motiv and Slay - Shots 44. Die Antwood - I Think U Freaky 45. Alibi, Melinki and Macca - Bad Trip (VIP) 46. DJ Andy and Dunk - Say Something 47. Sheena - Losing My Mind 48. Serum - Ride The Dx 49. Mozey - Missing Calls ft. Catching Cairo

Hiding the agenda for depopulation thru the vaccines and boosters is becoming more and more of a difficult task these days for the NFL and the entire professional sports industry. ORRA talks about how the smoke and mirrors media, along with the NFL is trying to spin the story with Damar Hamlin (Safety) for the NY Baffalo Bills, Cardiac Arrest episode on the field a couple of days ago. The NFL has a major problem on their hands with many players dying after taking the Covid-19 Vaccines and Booster shots. Good luck!

Hiding the agenda for depopulation thru the vaccines and boosters is becoming more and more of a difficult task these days for the NFL and the entire professional sports industry. ORRA talks about how the smoke and mirrors media, along with the NFL is trying to spin the story with Damar Hamlin (Safety) for the NY Baffalo Bills, Cardiac Arrest episode on the field a couple of days ago. The NFL has a major problem on their hands with many players dying after taking the Covid-19 Vaccines and Booster shots. Good luck!

A new research paper was published in Oncotarget's Volume 13 on December 17, 2022, entitled, “Serum microRNAs as new criteria for referral to early palliative care services in treatment-naïve advanced cancer patients.” A major obstacle to the implementation of early palliative care (EPC) is the lack of objective criteria for referral to EPC. Circulating microRNAs (miRNAs) have been recognized as promising biomarkers. In the current study, researchers Tomofumi Miura, Shuichi Mitsunaga, Juntaro Matsuzaki, Satoko Takizawa, Ken Kato, Atsushi Ochiai, and Takahiro Ochiya from National Cancer Center Research Institute, National Cancer Center Hospital, Keio University, Toray Industries, Inc., and Tokyo Medical University investigated objective definitions for referral to EPC using microRNA. A total of 178 serum samples were obtained from patients with lung, gastrointestinal, colorectal, bile duct, pancreas, and bladder cancers who were treatment-naïve and received chemotherapy between January 2011 and December 2013 at National Cancer Center Hospital East. “The aim of the present study was to develop predictive models using serum miRNAs for patients who [were] admitted to a PCU [palliative care unit] ≤6 months after starting anti-tumor treatment.” The team investigated expression levels of miRNAs using microarrays. The primary outcome was prediction of admission to a palliative care unit ≤6 months after first visit. Diagnostic models using clinical characteristics, miRNAs and combinations of both were constructed. The miRNA models were constructed using 6 miRNA levels. The best areas under the receiver operating characteristic curve (AUCs) of the clinical model was 0.741, while the average AUCs of miRNA-based models and combination models were 0.769 and 0.806, respectively. Combination models showed higher AUCs than the clinical model (p < 0.023). The researchers assert that the present combination models might offer new objective definitions for referral to EPC and thus contribute to real-world implementation of EPC. “The present study developed a predictive model using miRNA for patients admitted to a PCU ≤6 months after starting anti-tumor treatment. The present models might offer objective criteria for oncologists to facilitate the referral of patients to the EPC.” DOI: https://doi.org/10.18632/oncotarget.28327 Correspondence to: Shuichi Mitsunaga - smitsuna@east.ncc.go.jp Keywords: microRNA, early palliative care, integration, cancer, referral About Oncotarget: Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, visit Oncotarget.com and connect with us on social media: Twitter - https://twitter.com/Oncotarget Facebook - https://www.facebook.com/Oncotarget YouTube – www.youtube.com/c/OncotargetYouTube Instagram - https://www.instagram.com/oncotargetjrnl/ LinkedIn - https://www.linkedin.com/company/oncotarget/ Pinterest - https://www.pinterest.com/oncotarget/ LabTube - https://www.labtube.tv/channel/MTY5OA SoundCloud - https://soundcloud.com/oncotarget For media inquiries, please contact: media@impactjournals.com.

Mr Jim's Puzzle Is Now AvailableYes, Mr Jim made a mystery puzzle where its up to you to solve who the mystery animal is! Each Puzzle includes a 54 piece jigsaw puzzle, a Mr Jim audio story, and the mystery animal toy from Schleich®.—> Puzzables Join the HEYMRJIM Family Birthday Shout Out