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Featuring perspectives from Dr Floor J Backes, Dr Brian M Slomovitz and Dr Shannon N Westin, moderated by Dr Westin, including the following topics: Introduction (00:00) Current Up-Front Chemoimmunotherapeutic Approaches for Advanced Endometrial Cancer (EC) — Dr Backes (1:50) Current and Future Role of Anti-PD-1/PD-L1 Antibodies in Combination with Systemic Therapies Beyond Chemotherapy for Advanced EC — Dr Westin (33:15) Promising Agents Under Investigation for EC — Dr Slomovitz (1:01:41) CME information and select publications
What's up bros? Well, we found the worst hanxiety/TikTok combination and that's apparently getting drunk and then watching people all over talk about you being drunk and exaggerating what you were doing. Count us in for never wanting that action. While Riley struggles to come to grips with exactly what happened and who played what role, Shai is struggling with whether he should tell Hudson that Liam is hitting on his ex - he should totally ask Charlie what to do. On the subject of Charlie, everyone needs to get over their issue with him if they want the show to be successful. That's it. Learn more about your ad choices. Visit megaphone.fm/adchoices
Could your favourite sweet treat improve your workout? The team dives into the surprising research linking chocolate and exercise, exploring why this unlikely pairing has fitness fans talking. It might just change the way you think about your pre or post-gym snack.See omnystudio.com/listener for privacy information.
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. Although many GISTs can be effectively treated with targeted therapies, their response to treatment depends largely on the specific genetic alterations driving tumor growth. Advances in molecular testing have transformed the management of these tumors, allowing clinicians to tailor treatment based on each patient's genetic profile. A case report published in Volume 17 of Oncotarget, titled “Small bowel GIST harboring concurrent KIT exon 9 duplication and SDHC mutation: A case report,” describes an exceptionally rare case involving a patient whose tumor carried two genetic alterations that are traditionally considered mutually exclusive. Full blog post - https://www.oncotarget.org/2026/07/13/rare-genetic-combination-in-gastrointestinal-tumor-offers-new-insights-into-precision-cancer-care/ DOI - https://doi.org/10.18632/oncotarget.28863 Correspondence to - Joseph G. Crompton - jcrompton@mednet.ucla.edu Abstract video - https://www.youtube.com/watch?v=eB_QG2vBNCE Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28863 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, GIST, KIT duplication, SDHC mutation, genetic testing, case report To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM
Preview for Later Today: Lorenzo Fior recommends an Italian meal near the Dolomites, focusing on ciabatta bread paired with various sauces and white wines. He suggests concluding the dining experience with the traditional combination of chocolate and grappa.1540 MILAN
Send us Fan MailAuthor, pirate, and return guest Liz Shipton stops by to talk about engaging in real-world issues through speculative fiction with a focus on humor and female rage, and how those aspects impacted the overall message of her story.▬Check out Liz's fantastical adventures on her website:https://lizshipton.com/Grab a copy of her books here:https://shop.lizshipton.com/Follow Liz's stories further on her socials:https://www.facebook.com/lizshiptonauthorhttps://www.instagram.com/lizshiptonauthor
Send us Fan MailIn a delicious pairing, we geek out on our obsession of recent back to back entertainment entrees: Astro Bot and Widow's Bay. www.BetterHelp.com/TheBarnhttp://www.betterhelp.com/TheBarn http://www.betterhelp.com/TheBarnThis episode is sponsored by www.betterhelp.com/TheBarn and brought to you as always by The Barn Media Group. YOUTUBE https://www.youtube.com/@TheBarnPodcastNetworkSPOTIFY https://open.spotify.com/show/09neXeCS8I0U8OZJroUGd4?si=2f9b8dfa5d2c4504APPLE https://podcasts.apple.com/podcast/id1625411141I HEART RADIO https://www.iheart.com/podcast/97160034/AMAZON https://music.amazon.com/podcasts/7aff7d00-c41b-4154-94cf-221a808e3595/the-barn
Featuring an interview with Dr Rana R McKay, including the following topics: Prostate Cancer Working Group (PCWG4) revised terminology (0:00) Cardiovascular effects associated with GnRH agonists versus antagonists; mechanism of action (2:17) Combination therapy using relugolix; factors affecting persistence and adherence to GnRH agents (12:06) Takeaways from the Phase III EMBARK study (19:36) Use of CAR (chimeric antigen receptor) T-cell therapy and T-cell engagers (27:20) Potential role of circulating tumor DNA minimal residual disease testing; use of olaparib/radium-223 (29:24) CME information and select publications
A study of 2,000 people has found that 27% enjoy apple slices with cheddar cheese, while 18% of people love chips and milkshakes.So, what are the strangest food combinations?JP McMahon, Chef, Restaurateur & Author joins Shane to discuss.
In the News · Justices say Constitution Protects People's Location History · Microsoft Is Giving Windows 10 Users Another Year of Security Updates · Comcast to Split into Two Separate Publicly Traded Companies · Polymarket has Reportedly been Paying Creators to Post Fake Betting Videos · Car Manufacturers Are Ditching Android Auto in 2026 · T-Mobile To Force Migrate Over 8 Million Customers To More Expensive Plans · Rising Personal Computer Price Hikes · Apple and Intel are Working Together on a Chip Manufacturing Partnership ITPro Series with Benjamin Rockwell · The Hidden Complexity of Adding just One More App From the Tech Corner · Intel Wants Cheap Windows Laptops to Stop Feeling Cheap · Replacing Google Search with a Combination of DuckDuckGo and Perplexity · What Are Flock Cameras? · IBM has the Blueprint for the Next Generation of AI Chips Technology Chatter with Benjamin Rockwell and Mark Brownstein · Keychron Keyboard and Keyboard Switch Differences
In this episode, hear from Brenda Gibson, former WakeMed Hospital Board Chair and WakeMed Foundation Board Chair, as she discusses the proposed WakeMed–Atrium Health strategic combination, highlighting its importance for patient access, healthcare capacity, and future growth. For more information visit wakemed.org/wakemed-atrium-combination.
Master the latest evidence-based meds and dual therapies to help your patients quit for good. Credit available for this activity expires: 6/25/27 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/pharmacological-and-combination-interventions-nicotine-2026a1000ldi?ecd=bdc_podcast_libsyn_mscpedu
Master the latest evidence-based meds and dual therapies to help your patients quit for good. Credit available for this activity expires: 06/25/2027 Earn Credit / Learning Objectives & Disclosures: https://www.staging.medscape.org/viewarticle/pharmacological-and-combination-interventions-nicotine-2026a1000ldi?ecd=bdc_podcast_libsyn_mscpedu
The MC5 pioneered punk, heavy metal and high energy mid-western rock in late 1960's Detroit and paid a heavy price. Hosts Nate Wilcox and Justin Bankston continue their discussion of rock documentaries. The discussion is based on the unreleased documentary https://www.youtube.com/watch?v=Wwg7d4xtXyc. This episode was originally dropped in 2022. GO TO THE LET IT ROLL SUBSTACK TO HEAR THE FULL EPISODE -- The final 15 minutes of this episode are exclusively for paying subscribers to the Let It Roll Substack. Also subscribe to the LET IT ROLL EXTRA feed on Apple, Spotify or your preferred podcast service to access the full episodes via your preferred podcast outlet. We've got all 350+ episodes listed, organized by mini-series, genre, era, co-host, guest and more. Please consider becoming a paid subscriber to support the show. Thanks! Email letitrollpodcast@gmail.com Follow us on Twitter. Let It Roll is proud to be part of Pantheon Podcasts Learn more about your ad choices. Visit megaphone.fm/adchoices
What Makes a Sports Bra Actually Work?A conversation with Nicola, senior researcher in bra and breast biomechanics at the University of PortsmouthIn this episode, I speak with Nicola about the science behind sports bras, breast movement, and what actually contributes to support during activity.Nicola works in breast and bra biomechanics, a field that looks at how breast tissue moves, how that movement changes during different activities, and how bras can help control that movement. We talk about why sports bras are much more than a comfort item: they are an important piece of equipment that can affect whether women feel able to run, train, compete, and stay physically active.A major focus of the conversation is a University of Portsmouth study looking at how different sports bra design features affect performance. The study tested 98 sports bras on 77 women in 34B and 34D sizes to understand which design features reduced breast movement during running.The paper identified five key sports bra characteristics linked to performance:Bra style: Encapsulation and combination styles performed better than compression-only styles.Material: Bras made primarily from nylon performed better than those made primarily from polyester.Underband adjustability: Adjustable underbands were linked with better support than pullover styles.Padding: Padding appeared to contribute to movement reduction, not just modesty.Neckline height: Higher necklines were associated with better support than lower necklines.One of the most interesting parts of the episode is the idea that sports bra performance is not just about making a bra tighter. Breast tissue moves forward and back, side to side, and up and down, and different sports create different movement patterns. This means a bra that works well for running may not be the same bra someone wants for weightlifting, rowing, golf, or other sports.Nicola also explains why compression bras are not always enough, especially for larger cup sizes. Compression styles hold the breasts against the chest wall, while encapsulation styles support each breast individually. Combination styles can offer both the structure of encapsulation and the familiar “held in” feeling of compression.We also discuss how much is still unknown. Even after identifying several design features that contribute to sports bra performance, a large portion of what makes a sports bra work remains unexplained. That leaves room for more research into fit, materials, movement, comfort, breathing, and sport-specific design.Sports bras are often treated as a simple clothing purchase, but this conversation frames them as a health and participation issue. A poorly fitting or poorly performing sports bra can affect comfort, confidence, posture, breathing, and whether someone wants to keep participating in sport or exercise.Nicola also talks about the importance of getting this information to the people who need it, including athletes, school girls, and everyday consumers. The goal is not just better products, but better education, so women and girls know they do not have to accept pain, discomfort, or lack of support as normal.Referenced paper: Norris, M., Blackmore, T., Horler, B., & Wakefield-Scurr, J. (2021). “How the characteristics of sports bras affect their performance.” Ergonomics, 64(3), 410–425. doi: 10.1080/00140139.2020.1829090
This episode breaks down what the WakeMed and Atrium Health combination means for patient care, clinical expertise, and community health across Wake County. Dr. Charles Harr, cardiovascular and thoracic surgeon and chief medical officer of WakeMed Raleigh campus and former U.S. Navy rear admiral, shares firsthand perspective on the health system merger and why it matters. Listen for insights on cardiac surgery advances, minimally invasive surgery, structural heart care, clinical research trials, and physician collaboration. Learn more and stay informed at wakemed.org/wakemed-atrium-combination. Learn more about Charles Harr, MD, MBA
LIsten in as we talk about the negative impact on influencers or practitioners that operate with passion and fear! Again, don't believe everything you hear, no matter how compelling. We discuss the distorted beliefs, mixed up information and partial truths that are projected onto followers.
Listen to consonant sounds in words and you may notice something: the consonants are often weaker to the point of being hard to hear. In fact, they are still having a noticeable impact on the word, but not in the way you may expect. Let's look at held sounds/stop sounds with the letter T + N, and see how these affect consonants in English, how they happen, when they happen, and how to practiceMore held T practice: https://youtu.be/X__-ORzyLbcGet a free podcast/mp3/audio version: https://open.spotify.com/show/7f77KK0bWJ8ohC3QWDDwVYMore weaking consonants practice: https://youtu.be/yrGUOvM5VuEWelcome to For Word, the platform dedicated to guiding you towards better spoken performance. We're constantly looking at techniques to add more vocal variety to how we talk by incorporating more softness and firmness to our, furrowing eyebrows, smiling, raising and lowering pitches, adding pauses in order to convey frustration, sadness, joy and nervousness, and considering how to add more breath to everything we say. Let's see how these elements of contrast, body language, and other elements of communication can lead to richer expression.#performance #poetry #speaking
(71) Magic Island - 10 Seconds For The CombinationBecome a supporter of this podcast: https://www.spreaker.com/podcast/harold-s-old-time-radio--4206392/support.
Do you find Artificial Intelligence (ai) baffling, mysterious, useful, fantastic, or dangerous…or any combination of those? It is a great... The post ai and ADHD, a great combination! appeared first on WebTalkRadio.net.
In this episode of Why Distance Learning, your hosts continue their conversation with Jered Borup — professor at George Mason University and one of the most-cited researchers in K-12 online learning — about what AI in education is actually doing to relationships, what social presence requires when "build a video lecture" can be done by a chatbot, and why teacher burnout is the real bottleneck the field doesn't want to talk about. Borup connects his earliest 2012 work on asynchronous video to his 2025 Open Praxis research on combining AI-generated text with human-created video, and argues that AI used to offload feedback erodes the very thing online learners need: the felt sense that the teacher is real and knows them.Together, the hosts and Jered explore the conflation of social media, video games, and ed tech in the parental imagination after the pandemic; how to use AI without replacing the relational core of teaching; why one-on-one asynchronous video may build social presence more reliably than synchronous Zoom classes; the DLAC Phase 2 research agenda Borup co-authored with Michael Barbour and Kristen DeBruler; the mental-health gap between teachers and other professionals with comparable education; and Borup's one-line answer to the show's title question — that personalization and Universal Design for Learning are easier to do online than off.This is Part 2 of a two-part conversation. Listen to Part 1 for the foundational ACE framework, the on-site mentor model, and the parent question.Key Topics"Emergency remote learning" vs. real online learning — what parents are still confusingSocial presence — old research, new tools (asynchronous video, AI-plus-human-video)The risk of offloading teacher feedback to AIAsynchronous one-on-one video as a relationship lever (vs. one-to-many Zoom)DLAC Research Agenda Phase 2 — what's keeping researchers up at nightTeacher mental health and the AI strain on top of pandemic strainAuthentic assessment and "we're too in love with the five-paragraph essay"Empathy as the core design move"Why distance learning?" — empowerment, personalization, UDLLinks & ResourcesJered Borup's site: https://sites.google.com/site/jeredborup/ACE Framework on EdTech Books: https://edtechbooks.org/encyclopedia/academic_communities_of_engagement_ace_frameworkA Framework for Establishing Social Presence Through the Combination of AI-generated Text with Human-created Video (Open Praxis, 2025): https://openpraxis.org/articles/10.55982/openpraxis.17.1.769Harnessing the Power of Generative AI to Support ALL Learners (Borup, Evmenova & Shin, 2024): https://www.researchgate.net/publication/380570253_Harnessing_the_Power_of_Generative_AI_to_Support_ALL_LearnersDLAC Research Agenda Phase Two (Borup, Barbour & DeBruler, Sept 2025): https://www.deelac.com/wp-content/uploads/2025/10/DLAC-Research-Agenda-Phase-2-Final-1052025.pdfBreaking Through the Screen: Practical Tips for Engaging Learners in the Online and Blended Classroom (Borup & Joan Kang Shin, National Geographic Learning): https://www.amazon.com/Breaking-Through-Screen-Practical-classroom/dp/0357541855K-12 Blended Teaching open-source book series: https://edtechbooks.org/k12blended_seriesJered's Google Scholar: https://scholar.google.com/citations?user=PGs7TacAAAAJ&hl=enPart 1 of this conversation: [LINK — add when published]Guest Bio: Jered BorupJered Borup is a professor in the Division of Learning Technologies at George Mason University and co-coordinator of the Learning Technologies in Schools graduate program. His research, grounded in six years of junior-high history teaching, focuses on K-12 online and blended learning: the support communities that surround a learner, the parental role in online education, and how generative AI can extend personalized support to historically underserved students. He earned his Ph.D. in Instructional Psychology and Technology from Brigham Young University and has been recognized as one of the top 2% most-cited researchers in his field.About the HostsSeth Fleischauer is the founder of Banyan Global Learning and host of Why Distance Learning. Through Banyan, he designs live virtual programs that connect K-12 classrooms to global peers and expert facilitators — building the kind of structured, human-centered distance learning the podcast explores. See https://banyangloballearning.com/Allyson Mitchell works with CILC, the Center for Interactive Learning and Collaboration, to help educators implement high-quality live virtual learning experiences across grade levels. Discover more at CILC.org.
Think energy, digestion, and weight. In this episode, Nurse Doza breaks down berberine — the metabolism-supporting supplement that helps regulate blood sugar, support a healthy insulin response, and improve cholesterol (LDL, HDL, total). Discover why MSW Nutrition's Berberine Plus is 5x more absorbable in the gut, how to dose it morning and night, and why it works at the level of your gut microbiome. The berberine supplement your metabolism has been waiting for. Featured Partner: MSW Nutrition — Berberine Plus MSW Nutrition's Berberine Plus delivers dihydroberberine (DHB) — the bioactive, highly absorbable form of berberine sourced from Berberis aristata — so you get berberine's full metabolic benefits at a fraction of the dose, without the gut upset that comes from mega-dosing standard berberine. That enhanced absorption is exactly why it's the berberine supplement Nurse Doza reaches for to support blood sugar, digestion, and weight — as discussed in this episode.
This week! A bit of Memorial Day catchup then Natalie Moon joins the show to discuss local comedy in Baltimore among other things like Seth MacFarlane Stuff, Bob’s Burgers, Big Bang Theory (for some reason), Widow’s Bay and more!!
Creativity through the lens of a lawyer, online entrepreneur, tech founder"Finding ways to combine things in original ways" Bobby is a Harvard Law Grad turned online entrepreneur—but he's NOT your typical lawyer. He doesn't do suits, he hates legalese more than you do, and he tends to make bad pop-culture references and dad jokes. With his extensive expertise from a 20+ year legal career, Bobby is now focusing on making the legal stuff simple for online business owners. He and his team developed the Plainly Legal™ software to automate legal protection for coaches, course creators, consultants, service providers, and other online business owners. Website: www.plainlylegal.comLinkedIn: www.linkedin.com/in/robertklinck/FB: www.facebook.com/robert.klinck.1Send us Fan Mail
In this episode Dr. Thad McDonald, (retired OBGYN and Chair of the WakeMed Board of Directors) explains what the strategic combination with Atrium Health means for patients and the community. He discusses how the partnership will speed development of local cancer services, preserve safety net care, and improve access to specialty services. Learn more and stay informed at https://www.wakemed.org/wakemed-atrium-combination.
– EVs and innovation – (Yet another) reason not to try to time the market – The compound power of combination – Why ‘adoption’ wins See omnystudio.com/listener for privacy information.
Welcome to the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice.In this Mind Moments episode, Todd Arnedt, PhD, professor of psychiatry and neurology at Michigan Medicine-University of Michigan, joins the podcast to discuss the recently published American Academy of Sleep Medicine clinical practice guideline on combination treatment for chronic insomnia disorder in adults. Arnedt explains the rationale behind formal recommendations for concurrent use of cognitive behavioral therapy for insomnia (CBT-I) and pharmacotherapy, particularly as combination treatment becomes increasingly common in clinical practice. The conversation reviews the evidence supporting CBT-I as the preferred foundational treatment approach, where combination therapy may offer advantages over pharmacotherapy alone, and how clinicians should think about factors such as symptom burden, treatment goals, access to CBT-I, and patient preference when selecting treatment strategies. Arnedt also outlines ongoing research gaps involving sequential treatment approaches, medication classes, long-term outcomes, and personalized insomnia care. Looking for more Sleep Disorders discussion? Check out the NeurologyLive® Sleep Disorders clinical focus page.Episode Breakdown: 1:15 – Why formal insomnia combination treatment guidance was needed 2:45 – Defining concurrent CBT-I and pharmacotherapy approaches 4:35 – Evidence supporting CBT-I as foundational insomnia treatment 7:15 – Situations where combination therapy may improve patient outcomes 7:50 – Neurology News Network 10:20 – Patient-specific factors influencing insomnia treatment selection 12:30 – Barriers involving CBT-I access, cost, and real-world implementation 16:55 – Research gaps surrounding sequencing, long-term outcomes, and personalization The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here: Topline Phase 2 CELIA Results Show Diranersen Misses Primary End Point in Early Alzheimer Disease FDA Grants Priority Review to Bayer's Asundexian for Secondary Stroke Prevention Dyne Submits BLA for Z-Rostudirsen in Exon 51 Skipping Duchenne Muscular Dystrophy Thanks for listening to the NeurologyLive® Mind Moments® podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com.
Minera Alamos has announced a positive pre-feasibility study for the Copperstone Gold Project. Magna Mining has reported Q1 2026 operating and financial results from the McCreedy West mine. Paramount Gold Nevada has released an updated feasibility study for the Grassy Mountain Gold Project. Exploration updates from Scorpio Gold, Andina Copper, Tocvan Ventures and American Pacific Mining. This episode of Mining Stock Daily is brought to you by... Revival Gold Vizsla SilverEquinox GoldIntegra Resources
Li-FT Power CEO Francis MacDonald joins Mining Stock Daily to discuss the company's completed combination with Winsome Resources and the strategic addition of the Adina lithium project in Quebec's rapidly emerging James Bay district. Francis explains why the consolidation of the Adina and Galina properties creates a significantly larger development opportunity, how existing infrastructure at the nearby Renard mine could accelerate production timelines, and why he believes James Bay could become the largest hard rock lithium district in the world. The conversation also provides updates from Yellowknife, where Li-FT continues expanding the Big East pegmatite system through ongoing drilling while balancing capital allocation between two major lithium development projects. With lithium prices rebounding sharply, multiple resource and engineering catalysts ahead, and continued consolidation opportunities on the table, Li-FT believes it is positioning itself as one of the leading lithium development companies in Canada.
In this episode of Talking Sleep, host Dr. Seema Khosla welcomes Dr. Daniel Buysse and Dr. Todd Arnedt, both members of the AASM clinical practice guideline committee, to discuss the newly released guidelines on combination treatment for chronic insomnia disorder in adults. Unlike previous guidelines, this new guidance specifically addresses what happens in real-world clinical practice: patients often request both cognitive behavioral therapy for insomnia (CBT-I) and pharmacotherapy, or arrive seeking medications while clinicians advocate for behavioral interventions. The guidelines provide evidence-based recommendations for navigating these combination treatment scenarios, incorporating patient preferences in ways previous guidelines did not. The conversation explores the guideline development process, including how committee members were selected and how diverse professional backgrounds enriched the discussion. Dr. Buysse and Dr. Arnedt explain why patient preference wasn't adequately reflected in original practice guidelines and how this updated version addresses that gap. The first recommendation receives detailed examination: In adults with chronic insomnia, the AASM suggests combination treatment with CBT-I plus medication over medication alone (conditional recommendation, low certainty of evidence). The experts clarify which medications were examined, including whether dual orexin receptor antagonists (DORAs) were included, and explain why evidence certainty is low despite numerous studies. Pharmaceutical sponsorship creates methodological differences—PSG outcomes, fixed time in bed requirements—that complicate interpretation. The high placebo response in insomnia trials adds another layer of complexity. Critical implementation questions arise: What does "combination therapy" actually mean? Should both treatments start simultaneously, or should one precede the other? Can patients start medications while awaiting CBT-I appointments given typical access delays? The second recommendation appears paradoxical: The AASM suggests against combination treatment over CBT-I alone, yet recommends combination over medication alone. Dr. Buysse and Dr. Arnedt explain this nuanced position—CBT-I alone remains superior, but for patients who prioritize rapid total sleep time improvement over daytime symptom reduction, combination therapy may be reasonable. The conversation addresses whether treatment order matters and whether clinical (not just insurance-driven) logic suggests a medication hierarchy—zolpidem before eszopiclone, the role of trazodone, when to consider ramelteon. A crucial question emerges: What about patients who refuse or cannot access CBT-I? How do these guidelines apply when the preferred behavioral treatment is unavailable or unwanted? Throughout, the experts emphasize that guidelines inform but don't dictate clinical decisions. Patient preferences, values, and individual circumstances must shape treatment plans. The guidelines provide evidence-based frameworks while acknowledging the complexity of real-world insomnia management. Whether you're treating chronic insomnia, navigating patient requests for medications, addressing CBT-I access barriers, or seeking evidence-based approaches to combination therapy, this episode provides essential guidance. Join us for this important conversation about balancing behavioral and pharmacological approaches to chronic insomnia in clinical practice.
AUA2026 Spotlight: PARP-Inhibitor Combination Treatments for the Urologic Care Team CME Available: https://cme.auanet.org/URL/PARP26ONL LEARNING OBJECTIVES: At the conclusion of this CME activity, participants will be able to: 1. Integrate biomarker and genetic testing principles into clinical workflows for patients with metastatic prostate cancer, including when to order testing, how to interpret HRR mutation results (inclusive of BRCA and non-BRCA), and how to address barriers to testing through multidisciplinary coordination. 2. Explain the mechanism of action of PARP inhibitors and the biological and clinical rationale for their use—both as monotherapy and in combination approaches—in the treatment of mPC. 3. Evaluate emerging efficacy and safety data on PARPi combinations, including patient subgroup analyses, sequencing strategies, and the role of combination therapy in different stages of mPC. 4. Apply best practices for side effect monitoring and mitigation in patients receiving PARP inhibitors alone or in combination, leveraging the multidisciplinary team for optimal therapy management and patient quality of life. 5. Implement guideline-concordant care strategies in practice, including genetic testing workflow implementation, coordination among care team members, and patient engagement in shared decision-making and clinical trial enrollment. 5. Utilize current evidence-based guidelines to select and sequence PARP inhibitor therapy for patients with mPC, optimizing oncologic outcomes while individualizing care based on molecular profile and patient-specific factors. ACKNOWLEDGEMENTS: Support provided by independent educational grants from: Astrazeneca Merck & Co., Inc Pfizer, Inc.
Sponsored By: → Santa Barbara Chocolate | CocoaDynamics available at https://SantaBarbaraChocolate.com. Use code DRG20 for 20% off. → Timeline | Timeline's clinically proven formula is now available at a new, lower price. Mitopure now starts at $79, when you go to https://timeline.com/DRG → AquaTru | Go to https://AquaTru.com now for 20% off (your purifier) using promo code DRG. AquaTru even comes with a 30-day best-tasting water guarantee. Episode Description You can eat 30 grams of fiber a day and still be making the wrong choice for your microbiome. Because it was never just about how much you eat. It's about where that fiber is actually fermenting in your colon. Dr. Karan Rajan is a surgeon, gut health expert, and one of the most followed doctors on the internet. He spent years operating on colon cancers and bowel disease before realizing the most powerful thing he could do was hand people the information they were never given. In this conversation he breaks down the gut in a way that will make you want to reorganize your entire kitchen by the time it's over. In this episode, you'll discover: • Why the old soluble vs insoluble fiber model is outdated and what fermentation geography actually means — and how eating only one type of fiber can cause gas and bloating even when you're hitting your daily target • Why the protein obsession sweeping wellness culture may be quietly turning your gut bacteria into gremlins, and what happens when your microbes run out of fiber to eat • How your microbiome can begin to change within 48 hours of increasing fiber intake, and the exact ramp up strategy Dr. Karan uses to avoid the gas and bloating that makes most people quit If you have a gut, this episode is for you. Find Dr. Karan: Instagram: https://www.instagram.com/drkaranrajan TikTok: https://www.tiktok.com/@dr.karanr YouTube: https://www.youtube.com/c/DrKaran Book: This Is Vital Information — https://www.amazon.com/This-Vital-Information-Everything-Embarrassed-ebook/dp/B0FHC36WLD Timestamps: 0:00 - Intro 1:58 - Meet Dr. Karan Rajan: Gut Surgeon Turned One of the Most Followed Doctors Online 3:02 - Rapid Fire: Ground vs. Whole Chia Seeds, the Gut-Skin Axis & How Often You Should Poop 9:03 - Why He Left Surgery to Educate Millions for Free 12:42 - The Microbiome: Medicine's "Dark Matter" (And Who's Really in Control) 15:22 - Could Your Microbiome Be Influencing Who You're Attracted To? 17:47 - The Gut-Brain Axis: Is Mental Health Treatment Missing a Huge Piece? 24:43 - What's Actually Exciting Right Now in Microbiome Science 29:47 - The Breakfast Swap That Changed His Life in Two Weeks 33:08 - Should You Be Eating More Like Your Ancestors? 35:54 - Fast, Medium & Slow Fermenting Fibers: Why It Matters Where Fiber Ferments in Your Colon 40:47 - Psyllium Husk, Chia Seeds & What Most Fiber Supplements Get Wrong 41:57 - The Best Foods for Your Microbiome (According to the Doc Who Studies It) 43:14 - Cooked and Cooled Starch & Why Freezing Bread Actually Works 44:07 - The Truth About Colonics: Helpful or Harmful? 46:41 - Your Microbiome Can Change Within 48 Hours — Here's How to Start 48:01 - The Fiber Fart Curve: Why Gas Is a Good Sign You're Doing It Right 50:33 - Why the Rise in Colon Cancer Is Directly Tied to Fiber Deficiency 51:42 - Too Much Protein, Not Enough Fiber: How You Turn Gut Bacteria Into Gremlins 56:27 - The Book & Why He Never Wants Anyone to Die of Embarrassment Again Learn more about your ad choices. Visit megaphone.fm/adchoices
China is preparing to launch the Shenzhou-23 crewed spaceship. The combination of the spaceship and its carrier rocket has been transferred to the launch area.
Proceedings from a live event on April 11, 2026, held during the 2026 SGO Annual Meeting on Women's Cancer and moderated by Dr Ritu Salani, including the following topics: Biology of Advanced Endometrial Cancer (EC); Optimal Approach to Biomarker Assessment in Patients with Newly Diagnosed Disease — Dr Backes (0:00) Current Up-Front Chemoimmunotherapeutic Approaches for Advanced EC — Dr Powell (25:18) Current and Future Role of Anti-PD-1/PD-L1 Antibodies in Combination with Systemic Therapies Beyond Chemotherapy in Advanced EC — Dr Salani (59:02) CME information and select publications
In this episode, Donald Gintzig, President & CEO of WakeMed Health & Hospitals, outlines specifics about the strategic combination with Atrium Health and why it matters for access, equity, and long-term community health in Wake County. Hear about the benefits of expanded services, new facilities, investments in southeast Raleigh and more that aim to improve care for all. Visit WakeMed.org/wakemed-atrium-combination to learn more.
As long as you tolerate it, it stays the same.But the moment you say, “No Lord, things have to change,” heaven begins to move. You are not separate from Him — He is the Head, you are the body; He is the Vine, you are the branch.In the beginning, the Spirit hovered… and when God spoke, light appearedThat same light now lives in you.When Word and Spirit come together, growth begins.Develop your prayer life. Stay filled with Spirit-inspired Word.As long as you tolerate it, it stays the same.But the moment you say, “No Lord, things have to change,” heaven begins to move. ✨You are not separate from Him — He is the Head, you are the body; He is the Vine, you are the branch.In the beginning, the Spirit hovered… and when God spoke, light appearedThat same light now lives in you.When Word and Spirit come together, growth begins.Develop your prayer life. Stay filled with Spirit-inspired Word.The Most Powerful Combination: Spirit + Word | सबसे शक्तिशाली संयोजन: आत्मा + वचन | Prophet Ezekiah Francis– – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – – Watch in Englishhttps://youtube.com/live/TtrURfXCvY4Watch in Tamil (தமிழ்) https://youtube.com/live/uyBino3oFjgWatch in Hindi (हिंदी) https://youtube.com/live/FS-a4t4CsxoWatch in Telugu (తెలుగు) https://youtube.com/live/qA_vjWh_36kWatch in Malayalam (മലയാളം) https://youtube.com/live/TiKSFxgzEngWatch in Kannada (ಕನ್ನಡ)https://youtube.com/live/ZqXQegWLgeg
PERWIRA (The Indonesian Society in Victoria), which actively organizes cultural events, will host Mahasuara at Prahran Market, Melbourne, on the 2nd of May 2026. This festival will feature Dangdut Koplo and Bollywood music. It will also feature stalls of Indonesian food, especially traditional Indonesian cuisine. - PERWIRA (Perhimpunan Warga Indonesia di Victoria) yang aktif menyelenggarakan acara-acara budaya itu, pada tanggal 2 Mei 2026 akan menyelenggarakan Mahasuara di Prahran Square, Melbourne. Yaitu festival musik Dangdut Koplo dan musik Bollywood. Yang diramaikan pula dengan stal-stal makanan khas Indonesia terutamanya.
In this episode of the WCNFluencer podcast, host Christopher MacLellan interviews Dr. Mark Goldstein, a founding member of GEM Research. Throughout the episode, Christopher and Dr. Goldstein discuss Dr. Goldstein's transition from private practice to a focus on clinical trials, particularly in Alzheimer's. The conversation covers the importance of clinical trials, the distinction between Alzheimer's and dementia, recognizing symptoms, current treatments, hereditary factors, and the broader research focus at JEM Research Institute. Dr. Goldstein emphasizes the need for early intervention and the potential for future breakthroughs in Alzheimer's treatment. Takeaways - Dr. Goldstein transitioned from private practice to clinical trials. - Clinical trials are essential for developing new medications. - Dementia is a broader term, with Alzheimer's being a major type. - Recognizing early symptoms is crucial for caregivers. - Biomarkers can help diagnose Alzheimer's earlier than before. - Current treatments slow progression but are not cures. - Hereditary factors can increase the risk of Alzheimer's. - GEM Research conducts trials for various neurological conditions. - Combination therapies may be the future of Alzheimer's treatment. - Participation in clinical trials is free and private. To learn more about Dr. Goldstein and JEM Research Institute, click HERE!
The Sunday Triple M NRL Catch Up - Paul Kent, Gorden Tallis, Ryan Girdler, Anthony Maroon
Victor Radley joins Josh Reynolds and Charlie White to chat about the Roosters’ solid start to 2026, Luke Keary’s media masterclass thus far, his thoughts on the new Origin eligibility and what it would mean to represent NSW, the temptation of joining the new PNG side, Tedesco’s epic form, and the DCE–Walker combination and how it is building. He also previews the Roosters–Broncos match on Saturday. Plus, we look at what is going on with the Bulldogs, the depleted Tigers taking on the Sharks, Melbourne’s must-win match against the Dolphins, and preview all of the Round Nine clashes in the NRL! Check out Triple M NRL's Instagram, Facebook, TikTok and YouTube!See omnystudio.com/listener for privacy information.
It's opening day of French Quarter Fest, and Dave talks about what makes Southeast Louisiana so special! Also, Dave Cohen talks about how the New Orleans City Council, on Thursday, in a 4-3 vote, approved the New Orleans Police Department's purchase of the $250,000 drone and docking station, despite opposition from residents and three city council members. Then, Dave has a discussion about the Louisiana Senate approving a bill (SB4) with a 26-7 vote, allowing local communities to vote on removing fluoride from their public water systems. Finally, Mike Strain, Commissioner of the Louisiana Department of Agriculture & Forestry, joins the show to discuss farmers saying they can't survive without migrant labor, then on the flip side, others said that farmers are being too greedy and won't pay an American wage.
* Exploring Vrontok* This is our second go at this topic* Located in the shadow of Sky Point* Desperate, lawless, crowded town built on the slave trade* Not a vacation spot!* Like Bartertown... but darker* Combination of town, slave market, and military base.* Stealing slaves is the most serious crime.* Only punishments for crime are enslavement or death.* Fortified by a high wall and dry moat with sharpened stakes.* Three gates: Empire Gate (SE), Vivane Gate (NE), Outlaw Gate (NW)* Theran citizens are not subject to laws in Vrontok* Mayor T'rask, former slaver with large force of thugs.* Taxes: House Tax, Guest Tax, Exit Tax* T'rask focused on keeping the Therans from getting upset.* Lots of business that serve the slave merchants: taverns, gambling halls, brothels.* Result of imperialism; empires thrive on exploited labor.* Reflections on Thera and Vrontok in light of present-day economic and political systems.* "Keep politics out of rpgs!" is a crock.* Contrast of Sky Point's wealth and power to Vrontok's "wretched hive"* Fourth Edition changes and updatesFind and Follow:Email: edsgpodcast@gmail.comYouTube: https://www.youtube.com/@EDSGPodcastFind and follow Josh: https://linktr.ee/LoreMerchantGet product information, developer blogs, and more at www.fasagames.comFASA Games on Facebook: https://www.facebook.com/fasagamesincOfficial Earthdawn Facebook Group: https://www.facebook.com/groups/officialearthdawnFASA Games Discord Channel: https://discord.gg/uuVwS9uEarthdawn West Marches: https://discord.gg/hhHDtXW
In this podcast episode, we break down our list of the best producer, artist, and engineer combinations in music. From iconic collaborations to legendary studio chemistry, we talk about the teams that created timeless records and changed the sound of music. If you're into music production, audio engineering, recording, and the creative process behind great songs, this episode is for you.➡️ Get Our Rosetta Plugins: https://helpmedevvon.com/s/rosettaseries➡️ The Black Vortex Plugin: https://helpmedevvon.com/s/theblackvortex➡️ Our Site With Goodies: https://helpmedevvon.com/s/helpmedevvon➡️Buy From Sweetwater: https://cutt.ly/7hamejT _________________________________________________________ ▶ JOIN OUR COMMUNITY HERE: ➡️ Become A Member Of This Channel To Access Perks:https://thehmdcircle.com➡️Instagram: https://instagram.com/helpmedevvon➡️Twitter: https://twitter.com/helpmedevvonEmail Me: helpmedevvon@gmail.com #mixing #mastering #tutorial
The Yeah C'mon Show 04/07/2026 - Combination? Listen to today's Track 13 here: https://youtu.be/m0JMCaKwOUY?si=4qSx0KpK5Svf-C6G
In the first hour of the Chase & Big Joe Show, the guys shared their question of the day. What is the best sports brother combination? Later in the hour, Chase & Big Joe answered some calls and texts about their question of the day. Listen to hear more.
Today we're taking listeners beyond technical skill and into one of the most critical yet often overlooked competencies in the operating room: emotional intelligence. In a profession defined by precision, timing, and high-stakes decision-making, the ability to understand and manage emotions can be just as vital as mastering airway management or pharmacology. Joining the conversation is Brian Barry, who brings a powerful perspective on how emotional intelligence shapes not only individual performance but also team dynamics, leadership effectiveness, and ultimately patient outcomes. Here's some of what you'll hear in this episode:
In the final episode of the 2025-2026 wrestling season, The Gazette sports writer KJ Pilcher and Iowa wrestling legend Dick Briggs discuss the NCAA Men's Wrestling Championship.
In this episode, we explore the Fifth Consensus Guidelines for the Management of Postoperative Nausea and Vomiting, the latest international update designed to guide clinicians toward more effective prevention and treatment strategies. These updated recommendations reflect a growing body of research and introduce several important shifts in how anesthesia providers approach PONV. From expanded use of multimodal prophylaxis to greater emphasis on risk reduction strategies and post-discharge nausea and vomiting, the new guidelines encourage clinicians to think more proactively and systematically about managing this common complication. Here's some of what you'll hear in this episode:
The Gazette sports writer KJ Pilcher and Iowa wrestling legend Dick Briggs discuss the upcoming Division 1 NCAA Wrestling Championship and recap the Division 3 NCAA Wrestling Championship results.