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ACOG recommends the use of oral or vaginal misoprostol, vaginal dinoprostone (either gel or insert), or mechanical methods for cervical ripening. Plus, it states, “Combination methods (pharmacologic and mechanical) are also effective”. The July 2026 ACOG CPG 9 states this regarding vaginal misoprostol compared to vaginal dinoprostone for labor induction: “Vaginal dinoprostone is effective for cervical ripening; however, vaginal misoprostol has higher efficacy and less need for oxytocin augmentation. The Cochrane database systematic review in 2010 that compared vaginal misoprostol with vaginal dinoprostone in 38 trials (7,022 participants) showed a lower rate of failure to achieve vaginal delivery in 24 hours (RR 0.77) and reduced need for oxytocin augmentation with misoprostol (RR 0.68). There were no differences in the rates of cesarean delivery or tachysystole with FHR changes”. Now, as of August 19, 2026, a new meta-analysis from BJOG is examining this comparison (vaginal miso vs vaginal dino) again. Did they find the same thing? Listen in for details. 1. G. Andersson, B. Greenfield, A. Hunt, et al., “ Vaginal Misoprostol Compared to Vaginal Dinoprostone for Induction of Labour: A Systematic Review and Meta-Analysis,” BJOG: An International Journal of Obstetrics & Gynaecology (2026): 1–12, https://doi.org/10.1111/1471-0528.70314.2. ACOG Clinical Practice Guideline No. 9: Cervical Ripening in Pregnancy
In this week's edition of Cougar Tales, Mitch Harper and Nate Slack break down a possible clue from BYU head coach Kalani Sitake, who may have accidentally revealed the Cougars' first uniform combination of the season during a media appearance.
Jason and Nick welcome media mentor and for Fox 7 news host to discuss Mathew McConaughey, doing the news, back to school, and life as an almost influencer. Plus! a round of How Much Does It Weigh?Bonus episodes available at patreon.com/jasondick or https://creators.spotify.com/pod/show/jason-dick/subscribe
Jeremy Zakis reports on the looming weather crisis in Australia, where meteorologists predict a "super El Niño" combined with a positive Indian Ocean Dipole. This rare combination is expected to cause extreme drought and record-breaking temperatures in New South Wales and Victoria. Zakis warns that a wet winter has fueled rampant eucalyptus growth, creating a massive volume of flammable oils. These conditions have "primed" the landscape for catastrophic wildfires. Residents are being urged to clear undergrowth immediately, as the upcoming fire season could surpass the severity of the devastating 2020–2021 bushfires. (12)
The Mecca Joint Defence Agreement, signed by Pakistan, Saudi Arabia and Turkey, has generated considerable interest on Chinese social media. One commentator described it as a “Sunni NATO,” while other discussions focused on declining United States' influence, Iran as a target, and the implications for India, with some suggesting that New Delhi should be on high alert.----more----Read full article here: https://theprint.in/opinion/eye-on-china/china-mecca-pact-us-west-asia-india/3011805/
What does it really take to put together a World Champion hitch?Freeman Yoder and Ross Honsberger join Kyle and Mark for a conversation about what goes on behind the scenes of a top-level hitch. From selecting the right horses and putting a team together to training, fitting and getting every detail just right, there's a lot more to building a championship hitch than what you see in the show ring.In Part 1, the guys dig into the foundation of a great hitch, what they look for in a horse, and the years of work it takes to get a team ready to compete at the highest level.And this conversation is just getting started. Part 2 is coming next.Thank you to our sponsors of Episode #155!Shipshewana Harness & Supplies Glenwood Snacks Pennwoods Equine Products INC. The Draft Horse Journal Summit Professional Services Do you have suggestions for future episodes? Do you have ideas of someone we should have join us? Please send us any comments or questions to the Rinehold Tack & Western Wear mailbag, podcast@naclassicseries.com
August 11, 2026, 4pm; Alarming new reporting finds that Donald Trump used his staff and White House journalists as decoys amid security threats from Iran, having them fly out of Turkey on the old Air Force One while Trump flew out on a separate unmarked aircraft. For more from Nicolle, follow and download her podcast, “The Best People with Nicolle Wallace,” wherever you get your podcasts.To listen to this show and other MS podcasts without ads, sign up for MS NOW Premium on Apple Podcasts. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
The Trump Family's Close Ties to the Tate Brothers Who Advocate Rape, Domination and Servility of Women and Girls | Trump Tries to Blame Big Oil For the Price at the Pump After Getting a $Billion in Exchange For Deregulation and the Blocking of Climate Suits | The Turkey/Saudi/Pakistan Defense Pact a Combination of Money, Nukes and Armies. backgroundbriefing.org/donate twitter.com/ianmastersmedia bsky.app/profile/ianmastersmedia.bsky.social linktr.ee/backgroundbriefing
This post officially kicks off my Venice Immersive 2025 coverage, see links to all 38 episodes and 30+ hours of interviews down below. We're starting off with the interview that I did with Doug Liman (co-founder of 30 Ninjas), Julina Tatlock (co-founder of 30 Ninjas), & Jed Weintrob (co-founder of 30 Ninjas), & Max Spear (Product Lead of Android XR at Google) about Asteroid on Saturday, August 30, 2025 at Venice Immersive in Venice, Italy. Here is the story synopsis for Asteroid: "Asteroid is an immersive film and interactive story extension made for the launch of Google's new Android XR platform. The 180° immersive short film is a high-stakes action thriller about a group of strangers who take an old Russian Soyuz rocket to mine a near-earth, treasure laden asteroid for a chance at unimaginable wealth. After the film, the experience continues and the audience enters the world of Asteroid when they receive an SOS from one of the characters, DK Metcalf, who was left for dead. The viewer becomes a player when they are invited to aid in DK's rescue. Through speaking with an AI-generated version of DK — played by the NFL player as himself — the user determines the truth about what happened on the asteroid and sends his exact location to NASA for rescue." Here are the contextual domains that are explored: Long distance travel [9] where someone is left behind (de facto exile) [12], and there is a rescue mission where you as a character [1] help out the protagonist [7] in the second half, but also a lot of mystery [12] to figure out and investigate [9] Here is the Elemental Center of Gravity: 1st Center of Gravity of Emotional Presence: cinematic Virtual Reality thriller that begins as a film and continues as an immersive story game. Combination of live-action 180-video along with CGI-driven animations also in 180-video2nd Center of Gravity of Earth Element / Environmental and Embodied Presence: Worldbuilding of sci-fi extraction of asteroid, you embody a character in story in the last part, and you break the fourth wall in the onboarding talking to the actor who plays a character via AI3rd Center of Gravity of Air Element / Mental and Social Presence: Conversational-driven AI Story Extension - You talk to the actor DK Metcalf at the beginning and with the character at the end. A bit of puzzling together of the myserious aspects of the story4th Center of Gravity of Fire Element / Active Presence: continues as an immersive story game - Improv convo + slightly nudged and directed exploration Archetypal Themes and Character Explored: Everyone are anti-heroes archetypes - Power and Greed vs Limitations, constraints, boundaries, death. Doug Liman says there aren't many anti-heroes in space movies, Han Solo is an exception. What if all of the characters were Han Solos? What drama would ensue? Artist Statement: "I've always thought of myself as an immersive filmmaker. The goal was to put the audience in the action, not to be sort of passively watching it. Now that the technology has caught up with us, I really can put the audience in the rocket. Asteroid is the story of a ragtag group of astronauts who booked a ride on a used Soyuz spacecraft. An asteroid passes near Earth. It's laden with precious metals and gems. If you can get there, you can become insanely wealthy. It's a modern gold rush." Trailer: https://vimeo.com/1163762576/d0d75004c2?fl=pl&fe=vl You can find links to my 30+ hours of my coverage from Venice Immersive 2025 across 39 episodes. I've categorized the experiences according to these "elemental genres," which is looking at the top two elemental centers of gravity. You can watch this talk on "Blending the Elements on Experiential Design" for more details. #1650: Sneak Peak of Venice Immersive 2025 Selection with Curators Liz Rosenthal and Michel Reilhac #1750: Doug Liman's "Asteroid" Short Immersive Film with Google Gemini Story Extension + Kickoff of Venice Immersive 2025 Coverage #1751: "Ghost Town" Narrative Integration in Puzzle Adventure with Exquisite Worldbuilding #1752: Blending Embodied Game & Narrative Genres with "One True Path, Part 1" #1753: Mixed Reality Town-Building and Sim Game "Wall Town Wonders" #1754: Screen Life Thriller "LILI" about Surveillance Fuses Game Design, Film, and MacBeth Adaptation #1755: Hand-Tracked Sign Language as Story Beat Triggers in "Eddie and I" #1756: Exploring Narrative Potential of Generative AI in "8pm and the Cat" #1757: Embody a Geranium in Immersive Comedy about Boredom in "The Great Escape" #1758: Reckoning with Mental Health Taboos in Japan with "If You See a Cat" Immersive Animation #1759: Mother-Daughter Team Explore Personal Challenges with Depression and Anxiety in "Mirage" Immersive Animation #1760: Immersive Fairy Tale about Automation with "The Sad Story of the Little Mouse Who Wanted to Become Somebody" #1761: Unpacking the Immersive Orchestral Mix of "1968" with Massimiliano Borghesi #1762: Fusing Experimental Immersive Animation with Cutting-Edge Orchestral Spatial Audio Mix in "1968" #1763: Blending Theater and 360 Video in "Re-Launching-Luigi-Broglio" #1764: Mixing Hand-Drawn Animation with 360 Video in "The Time Before" #1765: Immersive Action Thriller "Mulan 2125" Pushes the Edge of Graphical Fidelity #1766: Formula 1 LBE Experience "Black Cats & Chequered Flags" is an Immersive Biopic of Alberto Anscari #1767: Immersive Journey through Special Effects Pioneer Carlo Rambaldi's Paintings in "Alien Perspective" #1768: Symbolic Journey through Lithuania's Artist Mikalojus Konstantinas Čiurlionis' Paintings in "Creation of the World" #1769: Mixed Reality Musical on Avatars and Identity in "First Virtual Suit" #1770: Eastern Philosophy-Inspired Fusion of Theater and XR with "Mnemosyne" #1771: Environmental Storytelling in "The Great Orator" VR Diorama with Generative AI Experiments #1772: Climate Change Spatial Montage "Out of Nowhere" Aspires to Move Towards Rewilding Prevention #1773: "Collective Body" Assigns Elemental Avatars Based Upon Archetypal Dance Movements #1774: Combining Live Dance and Music in Immersive LBE Performance "L'ombre (The Shadow)" #1775: The Continuous Spatial One-Shot of Backlight's "La Magie Opera" LBE #1776: The Spatial Grammar Innovations of Dialectical Contrasts and Abstraction within "The Big Cube" #1777: Active Imagination, Associative Dream Logic, & Embodied Interactions in "Sense of Nowhere" #1778: Collaborative Social Game and Story of "Happy Shadow" #1779: "Heartbeat" Immersive, 1-on-1 Biometric Synchronization and Involuntary Collective Agency #1780: Recap of VRChat Worlds Gallery at Venice Immersive 2025 with Mike Salmon #1781: Winner of Venice Immersive 2025 "The Clouds Are Two Thousand Meters Up" Innovates on Gaussian Splats & Spatial Storytelling #1782: "A Long Goodbye" Wins 3rd Place Prize at Venice Immersive with Emotionally-Moving Story on Dementia and Spatial Grammar Innovations #1783: "Less Than 5gr of Saffron" Wins 2nd Place Prize at Venice Immersive with Spatial Poem Quill Animation #1784: The Incredible Spatial Transitions of "Dark Rooms" with Radical Consent Innovations #1785: The Landmark Achievements of "Blur" in Fusing Theater, Montage, Mixed Reality, and LBE VR #1786: Collective Reading Experience of "Constantinopoliad" Provokes Discussion on Defining "Immersive" #1787: Blending the Elements of Experiential Design & Process-Relational Foundations of the Elements This is a listener-supported podcast through the Voices of VR Patreon. Music: Fatality
I interviewed Leo Metcalf & Michael Golembewski about The Time Before on Friday, August 29, 2025 at Venice Immersive in Venice, Italy. Here is the story synopsis for The Time Before: "Trapped between waking life and dreams, Olly delves into his childhood memories, navigating the fantastical dreamscapes his sister created to shield them from a fractured home. A journey into the buried past that shapes who we are. His story unfolds across two realms: raw, hand-drawn memories captured in childhood sketches, and surreal underwater live-action dreamscapes. As memory and imagination blur, The Time Before explores the emotional weight of a volatile father, a mother lost in the fog of memory, and a sister who offered escape through imagination and dreams. A meditation on the stories we tell ourselves to survive, and what is lost in the telling." Here are the contextual domains that are explored: Combination of personal memories [1] as well fantastical dreamscapes [9] created with the help of his sibling / sister [3] in order to preserve identity and Self [1] in the context of a dissolving and traumatic family and home [4]. The neighborhood with nature [3]. Implicit themes of death [8], and the existential suffering from loss & grief [12] Here is the Elemental Center of Gravity: 1st Center of Gravity of Emotional Presence: Narrative-driven, immersive animation that represent memories and juxtaposed with 360 videos that represent dreams. The collision of the past with the future. The struggle to try to feel FEELINGS. Emotional Stuntedness. [MEMORY] [DREAMS]2nd Center of Gravity of Earth Element / Environmental and Embodied Presence: Mash-up of the virtual and the real, combining cinematic 360 video with hand-drawn animations. Also the spatial ambisonic audio mixed with more traditional stereo. Explores the lines between dreams, memories, and the combination of the two. Also created multi-layered montages of 360 video underwater shots to create a surreal, dreamlike texture3rd Center of Gravity of Fire Element / Active Presence: A few embodied interactions that reflect turning points in the narrative4th Center of Gravity of Air Element / Mental and Social Presence: Either Dialogue or narration. The speculative realm of dreams and imagination are core themes. [IMAGINATION] The normal RULES of reality have changed within dreams Archetypal Themes and Character Explored: This is a piece about escape, distortion, and the quiet cost of staying silent. Also, about MEMORY, IMAGINATION, and DREAMS. Dreams and Fantasy: "Olly delves into his childhood memories, navigating the fantastical dreamscapes his sister created to shield them from a fractured home." Ultimately trying to have a cathartic emotional expression. Battling all the ways in which we were shut down, locked up, or dealing with unexamined childhood traumas. "the difficulty many children, especially boys, carry into adulthood when taught to suppress emotion." Themes: "The Time Before explores the emotional weight of a volatile father, a mother lost in the fog of memory, and a sister who offered escape through imagination and dreams." A reckoning with the past and memories : "consider the fragility of their own memory" Artist Statement: "Much of who we are is shaped by childhood memories we can't fully recall, let alone understand — yet their emotional ripples run deep. The Time Before explores this terrain through the eyes of Olly, a boy retreating into shifting inner landscapes shaped by memory, imagination, and loss. The piece invites not just observation but emotional and physical participation. In the darkness of the headset, I hope participants will consider the fragility of their own memory — and the difficulty many children, especially boys, carry into adulthood when taught to suppress emotion. This is a piece about escape, distortion, and the quiet cost of staying silent." https://www.youtube.com/watch?v=-oahwg3hyE0 This is a listener-supported podcast through the Voices of VR Patreon. Music: Fatality
I interviewed Craig Quintero & Phoebe Greenberg about Blur on Friday, August 29, 2025 at Venice Immersive in Venice, Italy. Here is the story synopsis for Blur: "Blur presents a new myth for the modern age, where science has changed how we think about life and death. With cloning and advances in resurrection biology, we have obscured the boundaries between the living and the dead — the natural and the artificial. This extended reality theatrical production unfolds as a dreamscape, shifting between real and virtual, taking participants on a journey of reflection on grief and eternality." Here are the contextual domains that are explored: Some fundamental questions around LIFE [1] and DEATH [8]. Blur born out of a "desire to explore the emotional and ethical terrain where science, loss and imagination collide." Philosophical and ethical implications [9] of the science human cloning [9] as explored through the main story of a mother [4] who's child [5] has died [8]. Explores a speculative and imaginal space of scienced-based possibilities [9] with imagery reflecting these moral and ethical dilemmas [9] around these hybrid entities [Combination of [1] Self with [7] ]. Also the implications of taking extinct animals [8] like the Wooley Mammoth or Dire Wolf, and resurrecting them through science [9], and bringing them back to life [1]. Here is the Elemental Center of Gravity: 1st Center of Gravity of Earth Element / Environmental and Embodied Presence: Blend of Immersive VR, CGI, Cinematic 360 video, 180 video, Mixed Reality. With specific architectural modulations, live performance, and integrations of your embodiment. Some Generative AI around your representations of embodied identity. There's also a LOT of invisible spatial choreography that is happening behind the scenes in order to move a number of human bodies through a physical space without colliding into each other, whilst also creating a seamless virtually-mediate spatial journey that is also A LOT MORE VAST than the constraints of the physical space. So it really feels like being taken on an expansive journey through space and time within this piece.2nd Center of Gravity of Air Element / Mental and Social Presence: Constant perversion of expectations and experience of having the "rug pulled out from underneath you." Symbolic Dream Logic, and Theatre of the Absurd. There's a lot of abstract and semiotic associative linking that Quintero describes as a "Rauschenberg-like collage" blending and blurring together lots of various archetypal forms to communicate their message. There's definitely a narrative to be parsed, but you have to sort of piece it together as there's a lot of symbolic communication, as well as expectation-perversion that either creates a deep sense of awe and wonder, or it can also be confusion for some where the overall plausibilty throughline and suspension of disbelief results more in a break in presence from a "I don't get it" experience rather than a deepening of awe from an unbounded possibility space. Overall feels a bit like waking from a dream, and then trying to parse it. There is also a moment of a theatre-for-one encounter, and then later more of a collective experience.3rd Center of Gravity of Fire Element / Active Presence: LIVE PERFORMANCE of theatrical actors. There's some constructed locomotive agency within bounds to replicate wandering. Some more interactive parts near the end. No real agency to change the flow of the narrative4th Center of Gravity of Water Element / Emotional Presence: Cinematic VR, but also a specific cadence and pacing of the narrative. Archetypal Themes and Character Explored: Blur explores "fundamental questions of identity and selfhood, and what makes 'me' me?" The strurctures of our society and science mashed up against the dissolving and dissolution of the boundaries between the science and humanity bringing questions around the archetypal qualities that make us uniquely human. The idealized image of the human form from evolution, then gets dissolved through hybrid combinations, that is also amplified by the actual blending and blurring of communication media from MR to VR to Invidual and Collective Theatrical Performances to Architecture with bit of magic thrown in. It's a seamless use of the forms of immersive and experiential to amplify the overall themes of the piece. What is Imaginal / Virtual / Synthetic / Artificial / Eternal? vs What is Real and Mortal? Life vs Death in the context of Scientific Truths and Technological Advance. "With cloning and advances in resurrection biology, we have obscured the boundaries between the living and the dead — the natural and the artificial." Artist Statement: "Blur was born from a shared desire to explore the emotional and ethical terrain where science, loss and imagination collide.Meeting in Venice, we recognised a deep alignment in poetic storytelling and a fascination with questions raised by cloning, bioengineering and de-extinction. The work examines the human urge to transcend death and the consequences of reshaping life. Combining immersive theatre, motion capture, passthrough, VR and AR, we invite audiences into a sensorial and surreal journey — where AI, myth and grief intersect. Blur is both a cautionary tale and a meditation on fragile humanity: a boundary-pushing experience that challenges perception while grounded in universal emotions." https://www.youtube.com/watch?v=SFXTon0-tQ0 This is a listener-supported podcast through the Voices of VR Patreon. Music: Fatality
Parshas Re'eh: Blessings and Life, A Winning Combination https://jewishprolifefoundation.org/pro-life-blog/parshas-re-eh-blessings-and-life-a-winning-combination פרשת ראה: ברכות וחיים, שילוב מנצח https://jewishprolifefoundation.co.il/%d7%94%d7%a4%d7%9c%d7%94-%d7%a4%d7%a8%d7%a9%d7%aa-%d7%a8%d7%90%d7%94-%d7%a7%d7%93%d7%95%d7%a9%d7%aa-%d7%97%d7%99%d7%99-%d7%94%d7%90%d7%93%d7%9d-%d7%a0%d7%a1-%d7%94%d7%9c%d7%99%d7%93%d7%94-%d7%aa/ At the Jewish Pro-Life Foundation, we're making the original pro-life religion pro-life again! News, education, enlightenment and spiritual renewal. Saving Jewish Lives & Healing Jewish Hearts by providing the Jewish community with Pro-Life Education, Pregnancy Care and Adoption Referrals, and Healing After Abortion. To learn more visit https://jewishprolifefoundation.org/ Banned 3.18.26. No longer Follow us on Facebook: https://www.facebook.com/JewishProLifeFoundation/ Follow us on Twitter: https://twitter.com/JewishProLife Follow us on YouTube: https://www.youtube.com/channel/UCk8B3l4KxJX4T9l8F5l-wkQ Follow us on TikTok: https://www.tiktok.com/@jewishprolife Follow us on MeWe: https://mewe.com/i/cecilyroutman Follow us on Gab: https://gab.com/JewishProLife Follow us on LinkedIn: https://www.linkedin.com/in/cecily-routman-3085ab140/ Banned 3.18.26. No longer Follow us on Instagram https://www.instagram.com/cecilyroutman/ Follow us on Gettr: https://gettr.com/user/prolifececily Follow us on Rumble: https://rumble.com/c/JewishProLifeFoundation Follow us on TruthSocial: https://truthsocial.com/@prolifececily Follow us on Telegram: https://t.me/JewishProLife Follow us on Podcasts: https://jewishprolife.libsyn.com/ Donate: https://jewishprolifefoundation.org/donate In Israel: https://jewishprolifefoundation.co.il The Jewish Pro-Life Foundation is an IRS approved 501(c)3 non-profit educational public charity. We are committed to Torah and Jewish Tradition. We are not affiliated with any particular Jewish denomination, political organization or any other religious organization or movement.
Jace Lington and Bennett Nuss talk with NCLA President and Chief Legal Officer Mark Chenoweth about the evolving landscape of injunctions in the legal system, particularly in light of recent cases likeTrump v. CASA. They explore the definition and function of injunctions, the surge of nationwide injunctions during the Trump administration, and the implications of forum shopping in legal proceedings. The conversation also delves into the role of the Administrative Procedure Act in judicial review and the strategic maneuvers of agencies to circumvent judicial oversight.Check out NCLA's latest cases here"The Truth of Erasure: Universal Remedies for Universal Agency Actions," by T. Elliot Gaiser, Mathura Sridharan, and Nicholas Cordova"Nationwide Injunctions' Governance Problems: Forum-Shopping, Politicizing Courts, and Eroding Constitutional Structure," Ronald A. Cass"How Should the Court Respond to the Combination of Political Polarity, Legislative Impotence, and Executive Branch Overreach?" Richard J. Pierce, Jr.
In a world filled with competing voices, how do we hold firmly to the truth while continuing to love others well? In this message from 2 John, we explore the apostle John's timeless encouragement to walk in both truth and love—two qualities that are never meant to be separated. John reminds believers to remain faithful to the gospel, guard against false teaching, and encourage one another to keep following Christ with humility and grace. Along the way, we'll reflect on the value of personal relationships, the importance of biblical discernment, and the hope we have of one day seeing Jesus face to face. Whether you're studying 2 John for the first time or looking for fresh encouragement in your walk with Christ, this sermon offers practical, Scripture-centered insight for everyday faith. Join us as we discover how God's truth shapes genuine love and steadfast Christian living.
BUFFALO, NY — August 3, 2026 — A new #research paper was #published in Volume 18 of Aging on July 17, 2026, titled “Selective targeting of cancer and senescence via shared metabolic shifts extends lifespan of old mice.” The study was led by first author Zachery R. Robinson, and corresponding author and Aging editorial board member Irina M. Conboy, both from the Department of Bioengineering and QB3 Institute, University of California, Berkeley. The researchers developed a new combination therapy that selectively targets both cancer cells and senescent cells by exploiting metabolic vulnerabilities shared by these two cell types. In laboratory studies and aged mice, the treatment selectively eliminated senescent cells and reduced cancer cell viability while improving physical performance and extending lifespan without significant toxicity to healthy tissues. Cancer and aging are closely linked. As people age, senescent cells accumulate throughout the body. Although these cells no longer divide, they remain metabolically active and release inflammatory molecules known as the senescence-associated secretory phenotype (SASP), which contributes to chronic inflammation, tissue dysfunction, and tumor progression. Existing therapies such as the BCL-2/BCL-xL inhibitor navitoclax (ABT-263) can eliminate both cancer cells and senescent cells but require doses that frequently cause thrombocytopenia, a potentially serious reduction in platelet counts that has limited their clinical use. Full press release - https://www.aging-us.com/news-room/new-drug-combination-targets-cancer-and-senescent-cells-while-extending-lifespan-in-old-mice DOI - https://doi.org/10.18632/aging.206399 Corresponding author - Irina M. Conboy - irina@generationlab.co Abstract video - https://www.youtube.com/watch?v=7p5JMvy9Twg Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206399 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, senescence, cancer, metabolic shift, ATP To learn more about the journal, please visit https://www.Aging-US.com and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
Love and faith are the two spiritual forces that transform our lives from the inside out. Worry, struggle, and force will never accomplish what love and faith do with ease. Matter of fact worry, struggle, and force derail you from the good you desire. Trusting God (your intuition), expecting good, and cooperating with spiritual law create a magnetic power that attracts the very blessings we seek. Get a clear understanding of how Love and Faith are practical tools for transforming your life. "Love leads the way, and faith opens every door." For more information and/or to contact us go to: https://www.darrellanded.com/ To become a Patreon contributor vist the link: https://www.patreon.com/funniestthing Order a copy of, "The Great Seal: The Symbolic Guide for Happy and Successful Living" at: https://a.co/d/0f3dVXzx Order a copy of, "Step Out Boldly: The Hidden Meaning of The Statue of Liberty" at: https://a.co/d/01f77Cvw Email us directly at: DarrellandEd@gmail.com
How is the upcoming combination of SAFE and BECU going to change the future of banking in Northern California and Washington? On this episode of the Perfect Cents Podcast, Alex Becerra sits down with SAFE COO, Tiffani Vargas, and BECU Chief Member & Digital Experience Officer, Jason Rudman, to dive deep into what this historic credit union partnership actually means for members and local communities. Discover how both institutions are uniting under the "Coming Together, Member First" philosophy, combining cutting-edge technology with a deep commitment to community impact. From reducing member fees to expanding first-time homebuyer grants, learn how this combined force of nearly 2 million members aims to move people from financial access to true financial freedom! Don't forget to subscribe to stay updated on how we're helping our communities win! SAFE is federally insured by NCUA and is an equal housing opportunity lender. Community & Local Favorites: Mount Rainier National Park Big Sur State Park (CA) Visit Carmel-By-The-Sea Visit Napa Valley To check out the resources highlighted in this episode visit the links below. The Sacramento Bee - SAFE Credit Union makes the case for its pending merger with Seattle-area firm Gold Mountain California News Media | Future of SAFE is still local To learn more about SAFE Credit Union products and services visit: https://www.safecu.org/ To register for an upcoming Financial Wellness webinar visit: https://www.safecu.org/community/events To read the latest edition of SAFE's Beyond Everyday Banking blog visit: https://blog.safecu.org/ To contact the podcast team, email Podcast@safecu.org To watch this episode in video-format and access more financial education tips, subscribe to the SAFE Credit Union YouTube channel: https://www.youtube.com/@SAFECreditUnionCA
Enhance myeloma survival by safely leveraging modern intensive regimens and targeted immunotherapies. Credit available for this activity expires: 7/21/27 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/intensity-equation-aligning-multiple-myeloma-combination-2026a1000ntz?ecd=bdc_podcast_libsyn_mscpedu
Featuring perspectives from Dr Floor J Backes, Dr Brian M Slomovitz and Dr Shannon N Westin, moderated by Dr Westin, including the following topics: Introduction (00:00) Current Up-Front Chemoimmunotherapeutic Approaches for Advanced Endometrial Cancer (EC) — Dr Backes (1:50) Current and Future Role of Anti-PD-1/PD-L1 Antibodies in Combination with Systemic Therapies Beyond Chemotherapy for Advanced EC — Dr Westin (33:15) Promising Agents Under Investigation for EC — Dr Slomovitz (1:01:41) CME information and select publications
What's up bros? Well, we found the worst hanxiety/TikTok combination and that's apparently getting drunk and then watching people all over talk about you being drunk and exaggerating what you were doing. Count us in for never wanting that action. While Riley struggles to come to grips with exactly what happened and who played what role, Shai is struggling with whether he should tell Hudson that Liam is hitting on his ex - he should totally ask Charlie what to do. On the subject of Charlie, everyone needs to get over their issue with him if they want the show to be successful. That's it. Learn more about your ad choices. Visit megaphone.fm/adchoices
Could your favourite sweet treat improve your workout? The team dives into the surprising research linking chocolate and exercise, exploring why this unlikely pairing has fitness fans talking. It might just change the way you think about your pre or post-gym snack.See omnystudio.com/listener for privacy information.
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. Although many GISTs can be effectively treated with targeted therapies, their response to treatment depends largely on the specific genetic alterations driving tumor growth. Advances in molecular testing have transformed the management of these tumors, allowing clinicians to tailor treatment based on each patient's genetic profile. A case report published in Volume 17 of Oncotarget, titled “Small bowel GIST harboring concurrent KIT exon 9 duplication and SDHC mutation: A case report,” describes an exceptionally rare case involving a patient whose tumor carried two genetic alterations that are traditionally considered mutually exclusive. Full blog post - https://www.oncotarget.org/2026/07/13/rare-genetic-combination-in-gastrointestinal-tumor-offers-new-insights-into-precision-cancer-care/ DOI - https://doi.org/10.18632/oncotarget.28863 Correspondence to - Joseph G. Crompton - jcrompton@mednet.ucla.edu Abstract video - https://www.youtube.com/watch?v=eB_QG2vBNCE Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28863 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, GIST, KIT duplication, SDHC mutation, genetic testing, case report To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM
Preview for Later Today: Lorenzo Fior recommends an Italian meal near the Dolomites, focusing on ciabatta bread paired with various sauces and white wines. He suggests concluding the dining experience with the traditional combination of chocolate and grappa.1540 MILAN
Send us Fan MailAuthor, pirate, and return guest Liz Shipton stops by to talk about engaging in real-world issues through speculative fiction with a focus on humor and female rage, and how those aspects impacted the overall message of her story.▬Check out Liz's fantastical adventures on her website:https://lizshipton.com/Grab a copy of her books here:https://shop.lizshipton.com/Follow Liz's stories further on her socials:https://www.facebook.com/lizshiptonauthorhttps://www.instagram.com/lizshiptonauthor
Why is SAFE Credit Union combining with BECU? On this episode of the Perfect Cents Podcast, SAFE President and CEO Faye Nabhani sits down to explain the strategic vision behind this combination and what it actually means for members and the community. Discover how this new partnership will drive greater member value through lower fees, competitive rates, and expanded consumer and small business loan opportunities. Faye shares insights on why now is the perfect time for this evolution while maintaining their core "people helping people" mindset. SAFE is federally insured by NCUA and is an equal housing opportunity lender. Community & Local Favorites: Eat A Pita - Rancho Cordova To check out the resources highlighted in this episode visit the links below. The Sacramento Bee - SAFE Credit Union makes the case for its pending merger with Seattle-area firm To learn more about SAFE Credit Union products and services visit: https://www.safecu.org/ To register for an upcoming Financial Wellness webinar visit: https://www.safecu.org/community/events To read the latest edition of SAFE's Beyond Everyday Banking blog visit: https://blog.safecu.org/ To contact the podcast team, email Podcast@safecu.org To watch this episode in video-format and access more financial education tips, subscribe to the SAFE Credit Union YouTube channel: https://www.youtube.com/@SAFECreditUnionCA
Send us Fan MailIn a delicious pairing, we geek out on our obsession of recent back to back entertainment entrees: Astro Bot and Widow's Bay. www.BetterHelp.com/TheBarnhttp://www.betterhelp.com/TheBarn http://www.betterhelp.com/TheBarnThis episode is sponsored by www.betterhelp.com/TheBarn and brought to you as always by The Barn Media Group. YOUTUBE https://www.youtube.com/@TheBarnPodcastNetworkSPOTIFY https://open.spotify.com/show/09neXeCS8I0U8OZJroUGd4?si=2f9b8dfa5d2c4504APPLE https://podcasts.apple.com/podcast/id1625411141I HEART RADIO https://www.iheart.com/podcast/97160034/AMAZON https://music.amazon.com/podcasts/7aff7d00-c41b-4154-94cf-221a808e3595/the-barn
Featuring an interview with Dr Rana R McKay, including the following topics: Prostate Cancer Working Group (PCWG4) revised terminology (0:00) Cardiovascular effects associated with GnRH agonists versus antagonists; mechanism of action (2:17) Combination therapy using relugolix; factors affecting persistence and adherence to GnRH agents (12:06) Takeaways from the Phase III EMBARK study (19:36) Use of CAR (chimeric antigen receptor) T-cell therapy and T-cell engagers (27:20) Potential role of circulating tumor DNA minimal residual disease testing; use of olaparib/radium-223 (29:24) CME information and select publications
A study of 2,000 people has found that 27% enjoy apple slices with cheddar cheese, while 18% of people love chips and milkshakes.So, what are the strangest food combinations?JP McMahon, Chef, Restaurateur & Author joins Shane to discuss.
In the News · Justices say Constitution Protects People's Location History · Microsoft Is Giving Windows 10 Users Another Year of Security Updates · Comcast to Split into Two Separate Publicly Traded Companies · Polymarket has Reportedly been Paying Creators to Post Fake Betting Videos · Car Manufacturers Are Ditching Android Auto in 2026 · T-Mobile To Force Migrate Over 8 Million Customers To More Expensive Plans · Rising Personal Computer Price Hikes · Apple and Intel are Working Together on a Chip Manufacturing Partnership ITPro Series with Benjamin Rockwell · The Hidden Complexity of Adding just One More App From the Tech Corner · Intel Wants Cheap Windows Laptops to Stop Feeling Cheap · Replacing Google Search with a Combination of DuckDuckGo and Perplexity · What Are Flock Cameras? · IBM has the Blueprint for the Next Generation of AI Chips Technology Chatter with Benjamin Rockwell and Mark Brownstein · Keychron Keyboard and Keyboard Switch Differences
In this episode, hear from Brenda Gibson, former WakeMed Hospital Board Chair and WakeMed Foundation Board Chair, as she discusses the proposed WakeMed–Atrium Health strategic combination, highlighting its importance for patient access, healthcare capacity, and future growth. For more information visit wakemed.org/wakemed-atrium-combination.
Master the latest evidence-based meds and dual therapies to help your patients quit for good. Credit available for this activity expires: 6/25/27 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/pharmacological-and-combination-interventions-nicotine-2026a1000ldi?ecd=bdc_podcast_libsyn_mscpedu
Master the latest evidence-based meds and dual therapies to help your patients quit for good. Credit available for this activity expires: 06/25/2027 Earn Credit / Learning Objectives & Disclosures: https://www.staging.medscape.org/viewarticle/pharmacological-and-combination-interventions-nicotine-2026a1000ldi?ecd=bdc_podcast_libsyn_mscpedu
The MC5 pioneered punk, heavy metal and high energy mid-western rock in late 1960's Detroit and paid a heavy price. Hosts Nate Wilcox and Justin Bankston continue their discussion of rock documentaries. The discussion is based on the unreleased documentary https://www.youtube.com/watch?v=Wwg7d4xtXyc. This episode was originally dropped in 2022. GO TO THE LET IT ROLL SUBSTACK TO HEAR THE FULL EPISODE -- The final 15 minutes of this episode are exclusively for paying subscribers to the Let It Roll Substack. Also subscribe to the LET IT ROLL EXTRA feed on Apple, Spotify or your preferred podcast service to access the full episodes via your preferred podcast outlet. We've got all 350+ episodes listed, organized by mini-series, genre, era, co-host, guest and more. Please consider becoming a paid subscriber to support the show. Thanks! Email letitrollpodcast@gmail.com Follow us on Twitter. Let It Roll is proud to be part of Pantheon Podcasts Learn more about your ad choices. Visit megaphone.fm/adchoices
What Makes a Sports Bra Actually Work?A conversation with Nicola, senior researcher in bra and breast biomechanics at the University of PortsmouthIn this episode, I speak with Nicola about the science behind sports bras, breast movement, and what actually contributes to support during activity.Nicola works in breast and bra biomechanics, a field that looks at how breast tissue moves, how that movement changes during different activities, and how bras can help control that movement. We talk about why sports bras are much more than a comfort item: they are an important piece of equipment that can affect whether women feel able to run, train, compete, and stay physically active.A major focus of the conversation is a University of Portsmouth study looking at how different sports bra design features affect performance. The study tested 98 sports bras on 77 women in 34B and 34D sizes to understand which design features reduced breast movement during running.The paper identified five key sports bra characteristics linked to performance:Bra style: Encapsulation and combination styles performed better than compression-only styles.Material: Bras made primarily from nylon performed better than those made primarily from polyester.Underband adjustability: Adjustable underbands were linked with better support than pullover styles.Padding: Padding appeared to contribute to movement reduction, not just modesty.Neckline height: Higher necklines were associated with better support than lower necklines.One of the most interesting parts of the episode is the idea that sports bra performance is not just about making a bra tighter. Breast tissue moves forward and back, side to side, and up and down, and different sports create different movement patterns. This means a bra that works well for running may not be the same bra someone wants for weightlifting, rowing, golf, or other sports.Nicola also explains why compression bras are not always enough, especially for larger cup sizes. Compression styles hold the breasts against the chest wall, while encapsulation styles support each breast individually. Combination styles can offer both the structure of encapsulation and the familiar “held in” feeling of compression.We also discuss how much is still unknown. Even after identifying several design features that contribute to sports bra performance, a large portion of what makes a sports bra work remains unexplained. That leaves room for more research into fit, materials, movement, comfort, breathing, and sport-specific design.Sports bras are often treated as a simple clothing purchase, but this conversation frames them as a health and participation issue. A poorly fitting or poorly performing sports bra can affect comfort, confidence, posture, breathing, and whether someone wants to keep participating in sport or exercise.Nicola also talks about the importance of getting this information to the people who need it, including athletes, school girls, and everyday consumers. The goal is not just better products, but better education, so women and girls know they do not have to accept pain, discomfort, or lack of support as normal.Referenced paper: Norris, M., Blackmore, T., Horler, B., & Wakefield-Scurr, J. (2021). “How the characteristics of sports bras affect their performance.” Ergonomics, 64(3), 410–425. doi: 10.1080/00140139.2020.1829090
This episode breaks down what the WakeMed and Atrium Health combination means for patient care, clinical expertise, and community health across Wake County. Dr. Charles Harr, cardiovascular and thoracic surgeon and chief medical officer of WakeMed Raleigh campus and former U.S. Navy rear admiral, shares firsthand perspective on the health system merger and why it matters. Listen for insights on cardiac surgery advances, minimally invasive surgery, structural heart care, clinical research trials, and physician collaboration. Learn more and stay informed at wakemed.org/wakemed-atrium-combination. Learn more about Charles Harr, MD, MBA
LIsten in as we talk about the negative impact on influencers or practitioners that operate with passion and fear! Again, don't believe everything you hear, no matter how compelling. We discuss the distorted beliefs, mixed up information and partial truths that are projected onto followers.
Listen to consonant sounds in words and you may notice something: the consonants are often weaker to the point of being hard to hear. In fact, they are still having a noticeable impact on the word, but not in the way you may expect. Let's look at held sounds/stop sounds with the letter T + N, and see how these affect consonants in English, how they happen, when they happen, and how to practiceMore held T practice: https://youtu.be/X__-ORzyLbcGet a free podcast/mp3/audio version: https://open.spotify.com/show/7f77KK0bWJ8ohC3QWDDwVYMore weaking consonants practice: https://youtu.be/yrGUOvM5VuEWelcome to For Word, the platform dedicated to guiding you towards better spoken performance. We're constantly looking at techniques to add more vocal variety to how we talk by incorporating more softness and firmness to our, furrowing eyebrows, smiling, raising and lowering pitches, adding pauses in order to convey frustration, sadness, joy and nervousness, and considering how to add more breath to everything we say. Let's see how these elements of contrast, body language, and other elements of communication can lead to richer expression.#performance #poetry #speaking
Do you find Artificial Intelligence (ai) baffling, mysterious, useful, fantastic, or dangerous…or any combination of those? It is a great... The post ai and ADHD, a great combination! appeared first on WebTalkRadio.net.
In this episode of Why Distance Learning, your hosts continue their conversation with Jered Borup — professor at George Mason University and one of the most-cited researchers in K-12 online learning — about what AI in education is actually doing to relationships, what social presence requires when "build a video lecture" can be done by a chatbot, and why teacher burnout is the real bottleneck the field doesn't want to talk about. Borup connects his earliest 2012 work on asynchronous video to his 2025 Open Praxis research on combining AI-generated text with human-created video, and argues that AI used to offload feedback erodes the very thing online learners need: the felt sense that the teacher is real and knows them.Together, the hosts and Jered explore the conflation of social media, video games, and ed tech in the parental imagination after the pandemic; how to use AI without replacing the relational core of teaching; why one-on-one asynchronous video may build social presence more reliably than synchronous Zoom classes; the DLAC Phase 2 research agenda Borup co-authored with Michael Barbour and Kristen DeBruler; the mental-health gap between teachers and other professionals with comparable education; and Borup's one-line answer to the show's title question — that personalization and Universal Design for Learning are easier to do online than off.This is Part 2 of a two-part conversation. Listen to Part 1 for the foundational ACE framework, the on-site mentor model, and the parent question.Key Topics"Emergency remote learning" vs. real online learning — what parents are still confusingSocial presence — old research, new tools (asynchronous video, AI-plus-human-video)The risk of offloading teacher feedback to AIAsynchronous one-on-one video as a relationship lever (vs. one-to-many Zoom)DLAC Research Agenda Phase 2 — what's keeping researchers up at nightTeacher mental health and the AI strain on top of pandemic strainAuthentic assessment and "we're too in love with the five-paragraph essay"Empathy as the core design move"Why distance learning?" — empowerment, personalization, UDLLinks & ResourcesJered Borup's site: https://sites.google.com/site/jeredborup/ACE Framework on EdTech Books: https://edtechbooks.org/encyclopedia/academic_communities_of_engagement_ace_frameworkA Framework for Establishing Social Presence Through the Combination of AI-generated Text with Human-created Video (Open Praxis, 2025): https://openpraxis.org/articles/10.55982/openpraxis.17.1.769Harnessing the Power of Generative AI to Support ALL Learners (Borup, Evmenova & Shin, 2024): https://www.researchgate.net/publication/380570253_Harnessing_the_Power_of_Generative_AI_to_Support_ALL_LearnersDLAC Research Agenda Phase Two (Borup, Barbour & DeBruler, Sept 2025): https://www.deelac.com/wp-content/uploads/2025/10/DLAC-Research-Agenda-Phase-2-Final-1052025.pdfBreaking Through the Screen: Practical Tips for Engaging Learners in the Online and Blended Classroom (Borup & Joan Kang Shin, National Geographic Learning): https://www.amazon.com/Breaking-Through-Screen-Practical-classroom/dp/0357541855K-12 Blended Teaching open-source book series: https://edtechbooks.org/k12blended_seriesJered's Google Scholar: https://scholar.google.com/citations?user=PGs7TacAAAAJ&hl=enPart 1 of this conversation: [LINK — add when published]Guest Bio: Jered BorupJered Borup is a professor in the Division of Learning Technologies at George Mason University and co-coordinator of the Learning Technologies in Schools graduate program. His research, grounded in six years of junior-high history teaching, focuses on K-12 online and blended learning: the support communities that surround a learner, the parental role in online education, and how generative AI can extend personalized support to historically underserved students. He earned his Ph.D. in Instructional Psychology and Technology from Brigham Young University and has been recognized as one of the top 2% most-cited researchers in his field.About the HostsSeth Fleischauer is the founder of Banyan Global Learning and host of Why Distance Learning. Through Banyan, he designs live virtual programs that connect K-12 classrooms to global peers and expert facilitators — building the kind of structured, human-centered distance learning the podcast explores. See https://banyangloballearning.com/Allyson Mitchell works with CILC, the Center for Interactive Learning and Collaboration, to help educators implement high-quality live virtual learning experiences across grade levels. Discover more at CILC.org.
Think energy, digestion, and weight. In this episode, Nurse Doza breaks down berberine — the metabolism-supporting supplement that helps regulate blood sugar, support a healthy insulin response, and improve cholesterol (LDL, HDL, total). Discover why MSW Nutrition's Berberine Plus is 5x more absorbable in the gut, how to dose it morning and night, and why it works at the level of your gut microbiome. The berberine supplement your metabolism has been waiting for. Featured Partner: MSW Nutrition — Berberine Plus MSW Nutrition's Berberine Plus delivers dihydroberberine (DHB) — the bioactive, highly absorbable form of berberine sourced from Berberis aristata — so you get berberine's full metabolic benefits at a fraction of the dose, without the gut upset that comes from mega-dosing standard berberine. That enhanced absorption is exactly why it's the berberine supplement Nurse Doza reaches for to support blood sugar, digestion, and weight — as discussed in this episode.
This week! A bit of Memorial Day catchup then Natalie Moon joins the show to discuss local comedy in Baltimore among other things like Seth MacFarlane Stuff, Bob’s Burgers, Big Bang Theory (for some reason), Widow’s Bay and more!!
Creativity through the lens of a lawyer, online entrepreneur, tech founder"Finding ways to combine things in original ways" Bobby is a Harvard Law Grad turned online entrepreneur—but he's NOT your typical lawyer. He doesn't do suits, he hates legalese more than you do, and he tends to make bad pop-culture references and dad jokes. With his extensive expertise from a 20+ year legal career, Bobby is now focusing on making the legal stuff simple for online business owners. He and his team developed the Plainly Legal™ software to automate legal protection for coaches, course creators, consultants, service providers, and other online business owners. Website: www.plainlylegal.comLinkedIn: www.linkedin.com/in/robertklinck/FB: www.facebook.com/robert.klinck.1Send us Fan Mail
In this episode Dr. Thad McDonald, (retired OBGYN and Chair of the WakeMed Board of Directors) explains what the strategic combination with Atrium Health means for patients and the community. He discusses how the partnership will speed development of local cancer services, preserve safety net care, and improve access to specialty services. Learn more and stay informed at https://www.wakemed.org/wakemed-atrium-combination.
– EVs and innovation – (Yet another) reason not to try to time the market – The compound power of combination – Why ‘adoption’ wins See omnystudio.com/listener for privacy information.
Welcome to the NeurologyLive® Mind Moments® podcast. Tune in to hear leaders in neurology sound off on topics that impact your clinical practice.In this Mind Moments episode, Todd Arnedt, PhD, professor of psychiatry and neurology at Michigan Medicine-University of Michigan, joins the podcast to discuss the recently published American Academy of Sleep Medicine clinical practice guideline on combination treatment for chronic insomnia disorder in adults. Arnedt explains the rationale behind formal recommendations for concurrent use of cognitive behavioral therapy for insomnia (CBT-I) and pharmacotherapy, particularly as combination treatment becomes increasingly common in clinical practice. The conversation reviews the evidence supporting CBT-I as the preferred foundational treatment approach, where combination therapy may offer advantages over pharmacotherapy alone, and how clinicians should think about factors such as symptom burden, treatment goals, access to CBT-I, and patient preference when selecting treatment strategies. Arnedt also outlines ongoing research gaps involving sequential treatment approaches, medication classes, long-term outcomes, and personalized insomnia care. Looking for more Sleep Disorders discussion? Check out the NeurologyLive® Sleep Disorders clinical focus page.Episode Breakdown: 1:15 – Why formal insomnia combination treatment guidance was needed 2:45 – Defining concurrent CBT-I and pharmacotherapy approaches 4:35 – Evidence supporting CBT-I as foundational insomnia treatment 7:15 – Situations where combination therapy may improve patient outcomes 7:50 – Neurology News Network 10:20 – Patient-specific factors influencing insomnia treatment selection 12:30 – Barriers involving CBT-I access, cost, and real-world implementation 16:55 – Research gaps surrounding sequencing, long-term outcomes, and personalization The stories featured in this week's Neurology News Minute, which will give you quick updates on the following developments in neurology, are further detailed here: Topline Phase 2 CELIA Results Show Diranersen Misses Primary End Point in Early Alzheimer Disease FDA Grants Priority Review to Bayer's Asundexian for Secondary Stroke Prevention Dyne Submits BLA for Z-Rostudirsen in Exon 51 Skipping Duchenne Muscular Dystrophy Thanks for listening to the NeurologyLive® Mind Moments® podcast. To support the show, be sure to rate, review, and subscribe wherever you listen to podcasts. For more neurology news and expert-driven content, visit neurologylive.com.
Minera Alamos has announced a positive pre-feasibility study for the Copperstone Gold Project. Magna Mining has reported Q1 2026 operating and financial results from the McCreedy West mine. Paramount Gold Nevada has released an updated feasibility study for the Grassy Mountain Gold Project. Exploration updates from Scorpio Gold, Andina Copper, Tocvan Ventures and American Pacific Mining. This episode of Mining Stock Daily is brought to you by... Revival Gold Vizsla SilverEquinox GoldIntegra Resources
Li-FT Power CEO Francis MacDonald joins Mining Stock Daily to discuss the company's completed combination with Winsome Resources and the strategic addition of the Adina lithium project in Quebec's rapidly emerging James Bay district. Francis explains why the consolidation of the Adina and Galina properties creates a significantly larger development opportunity, how existing infrastructure at the nearby Renard mine could accelerate production timelines, and why he believes James Bay could become the largest hard rock lithium district in the world. The conversation also provides updates from Yellowknife, where Li-FT continues expanding the Big East pegmatite system through ongoing drilling while balancing capital allocation between two major lithium development projects. With lithium prices rebounding sharply, multiple resource and engineering catalysts ahead, and continued consolidation opportunities on the table, Li-FT believes it is positioning itself as one of the leading lithium development companies in Canada.
In this episode of Talking Sleep, host Dr. Seema Khosla welcomes Dr. Daniel Buysse and Dr. Todd Arnedt, both members of the AASM clinical practice guideline committee, to discuss the newly released guidelines on combination treatment for chronic insomnia disorder in adults. Unlike previous guidelines, this new guidance specifically addresses what happens in real-world clinical practice: patients often request both cognitive behavioral therapy for insomnia (CBT-I) and pharmacotherapy, or arrive seeking medications while clinicians advocate for behavioral interventions. The guidelines provide evidence-based recommendations for navigating these combination treatment scenarios, incorporating patient preferences in ways previous guidelines did not. The conversation explores the guideline development process, including how committee members were selected and how diverse professional backgrounds enriched the discussion. Dr. Buysse and Dr. Arnedt explain why patient preference wasn't adequately reflected in original practice guidelines and how this updated version addresses that gap. The first recommendation receives detailed examination: In adults with chronic insomnia, the AASM suggests combination treatment with CBT-I plus medication over medication alone (conditional recommendation, low certainty of evidence). The experts clarify which medications were examined, including whether dual orexin receptor antagonists (DORAs) were included, and explain why evidence certainty is low despite numerous studies. Pharmaceutical sponsorship creates methodological differences—PSG outcomes, fixed time in bed requirements—that complicate interpretation. The high placebo response in insomnia trials adds another layer of complexity. Critical implementation questions arise: What does "combination therapy" actually mean? Should both treatments start simultaneously, or should one precede the other? Can patients start medications while awaiting CBT-I appointments given typical access delays? The second recommendation appears paradoxical: The AASM suggests against combination treatment over CBT-I alone, yet recommends combination over medication alone. Dr. Buysse and Dr. Arnedt explain this nuanced position—CBT-I alone remains superior, but for patients who prioritize rapid total sleep time improvement over daytime symptom reduction, combination therapy may be reasonable. The conversation addresses whether treatment order matters and whether clinical (not just insurance-driven) logic suggests a medication hierarchy—zolpidem before eszopiclone, the role of trazodone, when to consider ramelteon. A crucial question emerges: What about patients who refuse or cannot access CBT-I? How do these guidelines apply when the preferred behavioral treatment is unavailable or unwanted? Throughout, the experts emphasize that guidelines inform but don't dictate clinical decisions. Patient preferences, values, and individual circumstances must shape treatment plans. The guidelines provide evidence-based frameworks while acknowledging the complexity of real-world insomnia management. Whether you're treating chronic insomnia, navigating patient requests for medications, addressing CBT-I access barriers, or seeking evidence-based approaches to combination therapy, this episode provides essential guidance. Join us for this important conversation about balancing behavioral and pharmacological approaches to chronic insomnia in clinical practice.
Sponsored By: → Santa Barbara Chocolate | CocoaDynamics available at https://SantaBarbaraChocolate.com. Use code DRG20 for 20% off. → Timeline | Timeline's clinically proven formula is now available at a new, lower price. Mitopure now starts at $79, when you go to https://timeline.com/DRG → AquaTru | Go to https://AquaTru.com now for 20% off (your purifier) using promo code DRG. AquaTru even comes with a 30-day best-tasting water guarantee. Episode Description You can eat 30 grams of fiber a day and still be making the wrong choice for your microbiome. Because it was never just about how much you eat. It's about where that fiber is actually fermenting in your colon. Dr. Karan Rajan is a surgeon, gut health expert, and one of the most followed doctors on the internet. He spent years operating on colon cancers and bowel disease before realizing the most powerful thing he could do was hand people the information they were never given. In this conversation he breaks down the gut in a way that will make you want to reorganize your entire kitchen by the time it's over. In this episode, you'll discover: • Why the old soluble vs insoluble fiber model is outdated and what fermentation geography actually means — and how eating only one type of fiber can cause gas and bloating even when you're hitting your daily target • Why the protein obsession sweeping wellness culture may be quietly turning your gut bacteria into gremlins, and what happens when your microbes run out of fiber to eat • How your microbiome can begin to change within 48 hours of increasing fiber intake, and the exact ramp up strategy Dr. Karan uses to avoid the gas and bloating that makes most people quit If you have a gut, this episode is for you. Find Dr. Karan: Instagram: https://www.instagram.com/drkaranrajan TikTok: https://www.tiktok.com/@dr.karanr YouTube: https://www.youtube.com/c/DrKaran Book: This Is Vital Information — https://www.amazon.com/This-Vital-Information-Everything-Embarrassed-ebook/dp/B0FHC36WLD Timestamps: 0:00 - Intro 1:58 - Meet Dr. Karan Rajan: Gut Surgeon Turned One of the Most Followed Doctors Online 3:02 - Rapid Fire: Ground vs. Whole Chia Seeds, the Gut-Skin Axis & How Often You Should Poop 9:03 - Why He Left Surgery to Educate Millions for Free 12:42 - The Microbiome: Medicine's "Dark Matter" (And Who's Really in Control) 15:22 - Could Your Microbiome Be Influencing Who You're Attracted To? 17:47 - The Gut-Brain Axis: Is Mental Health Treatment Missing a Huge Piece? 24:43 - What's Actually Exciting Right Now in Microbiome Science 29:47 - The Breakfast Swap That Changed His Life in Two Weeks 33:08 - Should You Be Eating More Like Your Ancestors? 35:54 - Fast, Medium & Slow Fermenting Fibers: Why It Matters Where Fiber Ferments in Your Colon 40:47 - Psyllium Husk, Chia Seeds & What Most Fiber Supplements Get Wrong 41:57 - The Best Foods for Your Microbiome (According to the Doc Who Studies It) 43:14 - Cooked and Cooled Starch & Why Freezing Bread Actually Works 44:07 - The Truth About Colonics: Helpful or Harmful? 46:41 - Your Microbiome Can Change Within 48 Hours — Here's How to Start 48:01 - The Fiber Fart Curve: Why Gas Is a Good Sign You're Doing It Right 50:33 - Why the Rise in Colon Cancer Is Directly Tied to Fiber Deficiency 51:42 - Too Much Protein, Not Enough Fiber: How You Turn Gut Bacteria Into Gremlins 56:27 - The Book & Why He Never Wants Anyone to Die of Embarrassment Again Learn more about your ad choices. Visit megaphone.fm/adchoices
Proceedings from a live event on April 11, 2026, held during the 2026 SGO Annual Meeting on Women's Cancer and moderated by Dr Ritu Salani, including the following topics: Biology of Advanced Endometrial Cancer (EC); Optimal Approach to Biomarker Assessment in Patients with Newly Diagnosed Disease — Dr Backes (0:00) Current Up-Front Chemoimmunotherapeutic Approaches for Advanced EC — Dr Powell (25:18) Current and Future Role of Anti-PD-1/PD-L1 Antibodies in Combination with Systemic Therapies Beyond Chemotherapy in Advanced EC — Dr Salani (59:02) CME information and select publications