Podcasts about Combination

Featuring an interview with Dr Jacob Sands, including the following topics: Management of Adverse Events of Special Interest Associated with Datopotamab Deruxtecan (Dato-DXd) (0:00) Heist RS et al. Clinical management, monitoring, and prophylaxis of adverse events of special interest associated with datopotamab deruxtecan. Cancer Treat Rev 2024;125:102720. Abstract  Sands J et al. Analysis of drug-related interstitial lung disease (ILD) in patients (pts) treated with datopotamab deruxtecan (Dato-DXd). ASCO 2024;Abstract 8623. Intracranial Efficacy of Dato-DXd for Previously Treated Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) with Actionable Genomic Alterations in the TROPION-Lung05 Study (7:23) Lisberg A et al. Intracranial efficacy of datopotamab deruxtecan (Dato-DXd) in patients (pts) with previously treated advanced/metastatic non-small cell lung cancer (a/m NSCLC) with actionable genomic alterations (AGA): Results from TROPION-Lung05. ASCO 2024;Abstract 8593.  Clinical Evidence Supporting the Combination of Dato-DXd with Immune Checkpoint Inhibition for Advanced NSCLC (12:12) Bessede A et al. TROP2 is associated with primary resistance to immune checkpoint inhibition in patients with advanced non-small cell lung cancer. Clin Cancer Res 2024;30(4):779-85. Abstract Levy BP et al. TROPION-Lung02: Datopotamab deruxtecan (Dato-DXd) plus pembrolizumab (pembro) with or without platinum chemotherapy (Pt-CT) as first-line (1L) therapy for advanced non-small cell lung cancer (aNSCLC). ASCO 2025;Abstract 8501. Waqar SN et al. First-line (1L) datopotamab deruxtecan (Dato-DXd) + rilvegostomig in advanced or metastatic non-small cell lung cancer (a/mNSCLC): Results from TROPION-Lung04 (cohort 5). ASCO 2025;Abstract 8521. Current and Future Development of Antibody-Drug Conjugates in the Treatment of Lung Cancer (17:11) Tawfiq RK et al. Targeting lung cancer with precision: The ADC therapeutic revolution. Curr Oncol Rep 2025;27(6):669-86. Abstract CME information and select publications

The updated NICE guidance on asthma is ‘absolutely superb', advanced nurse practitioner Beverely (Bev) Bostock tells Dawn Liz Powell in this episode of the Clinical Update podcast. She explains that the guidance could help to improve asthma outcomes in the UK. ‘We're right at the top of the league for poor outcomes with asthma, and I suspect that that's about to change because we've finally taken on the approach that has been used in other countries,' Bev adds.She also talks about identifying occupational asthma, the diagnosis and management of COPD, the NHS lung cancer screening programme, and the need to keep the lungs clear of sputum in people with bronchiectasis.You can access the website version of this podcast, along with a list of key learning points, on MIMS Learning — and make notes for your appraisal. MIMS Learning offers hundreds of hours of CPD for healthcare professionals, along with a handy CPD organiser.Educational objectivesAfter listening to this podcast, healthcare professionals should be better able to: Identify the triggers for occupational asthmaDiscuss the key recommendations of the 2024 update to the NICE asthma guidanceReview the different subcategories of COPD, according to the GOLD guidelinesUnderstand how the NHS lung cancer screening programme has led to incidental findings of emphysemaPlease note: this podcast is presented by medical editors and discusses educational content written or presented by doctors, nurses and other healthcare professionals on the MIMS Learning website and at live events.MIMS LearningSubscribe to MIMS LearningGuidance update: BTS/NICE/SIGN guidelines on diagnosis, monitoring and chronic asthma managementPodcast: Dr Cara Bossley on asthma in childrenCOPD pathology and diagnosisMIMSCombination inhalers for the treatment of asthma Hosted on Acast. See acast.com/privacy for more information.

Summary:Join Jason Rogers and Garth Nichols for a deep dive into Phebe Trotman's book, Never Quit on a Bad Day. They explore the crucial role of resilience and showing up in leadership, particularly during difficult times. The discussion highlights the value of building a personal board of directors for mentorship and guidance, and the power of vulnerability in connecting with others. This episode is about leading with purpose, overcoming challenges, and finding joy in the journey.Top Takeaways:Showing Up Is Everything: A leader's presence, especially during tough times, is a powerful signal of support and commitment.Grit Is a Combination of Habits: Perseverance, positivity, and a commitment to continuous learning are the key components of true grit.The Power of Mentorship: A personal board of directors—a diverse group of mentors—provides invaluable perspectives and guidance for navigating challenges.Vulnerability Creates Connection: Leaders who are willing to be vulnerable foster trust and empower others to embrace their own struggles.Character Is Built Daily: Leadership and strong character are not inherent traits, but rather habits that are cultivated through consistent, daily effort.Sound Bites:"Character is a habit." "Keep leading and reading." "This book is an incredible gift." Chapters:00:00 - Introduction to Leadership and Bad Days 05:01 - The Importance of Showing Up 08:22 - Personal Board of Directors 11:14 - Resilience and Overcoming Challenges 13:09 - Leading with Joy and Authenticity 13:37 - Beards Book Club Outro (and a look at next week's book!)

Genetics are foundational to much of cancer treatment, and now both the environment surrounding the tumor as well as analysis of cancer cells shed into the blood may also be used to inform treatment as well. That's according to studies … A combination of strategies help determine best cancer treatment strategies, Elizabeth Tracey reports Read More »

今回のエピソードは： ・ヨシが変な食べ合わせでアウトした・ミステリアスなストレンジニュース・英語の可算／不可算のポイント解説【スポンサー】■世界で最も優れた 英語発音矯正アプリ「ELSA」ELSA Premium ライフタイムリンク（GoGoリスナーだけ！）⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://elsaspeak.com/inf/gogo-lifetime/?cache=no⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠■1年間有効のお手頃プラン！⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://elsaspeak.com/inf/gogo-eibu-premium/?cache=no⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠800回記念ビーチBBQパーティー参加登録はこちら：⁠⁠⁠https://www.55freebird.com/event-details/800kaikinen-bichibbq-party⁠⁠⁠ベアードビール（美味しいクラフトビール）クーポンコードは：GOGO10 (10% OFF)⁠⁠⁠⁠⁠https://bairdbeer.com/⁠⁠⁠⁠⁠　【ウェブサイト】問い合わせ/ ヨシのオンラインレッスン⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://55english.jp/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠エイブのサイト（オンラインレッスン・イベント等）⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.55freebird.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Free Bird English: Teacher Talk (エイブの100％英語番組）Apple:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://tinyurl.com/yr48m3av⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Spotify:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://tinyurl.com/27kstc5b⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠おしゃれアレルギーApple:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://tinyurl.com/28mzcpjw⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Spotify:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://tinyurl.com/ypkqp395⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠各種SNSは「GoGoエイブ会話」で検索してみてください♪【YouTubeチャンネル】GoGoエイブ 会話 YouTube チャネル：⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/channel/UCZSnkwixv3YMHVAsFheMSHg⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠#EnglishLearning #EnglishPodcast #LanguageLearning #StudyEnglish #EnglishSpeak #EnglishPractice #EFL #ESL #英語学習 #podcast #FBEteachertalk #バイリンガル #ネイティブ

In this powerful episode, Brandy reveals one of the most profound discoveries in mind-body healing: there's actually a formula for healing. You'll hear a live coaching session with a beautiful volunteer where hidden emotional patterns are uncovered and shifted in real time—leading to relief, new awareness, and genuine empowerment. One of the most eye-opening insights is seeing how different combinations of emotions affect the body in different ways—and how key it is to shift the mindset at a deeper, subconscious level for lasting results in both emotional healing and physical health. You'll discover: Why stress alone isn't the real cause—and what's actually happening  How guilt, perfectionism, and fear of rejection combine to affect the body What “reverse emotional processing” is and why it makes change possible A moving live demonstration of emotions shifting into freedom How to begin applying these self-healing techniques to your own journey This session is a powerful reminder of the mind-body connection and how, when we truly learn to work with our minds, we can unlock natural healing and transformation. If you've ever struggled with chronic health challenges, emotional blocks, or guilt that weighs you down, this episode will inspire you to see what's possible. Tune in and discover how much power you truly have when you learn to decode what your body is trying to tell you.   Disclaimer: This podcast is for educational purposes only and is not a substitute for psychiatric or medical care. If you struggle with negative thoughts, chronic pain, or chronic health issues, please continue seeing your doctor as recommended. Think of self-healing and mind-body healing as ways to partner with your doctor—keeping them informed and working as a team—so you can feel empowered in your health journey and fully embrace what's possible through the power of your mind, emotions, and energy. Genuine change and consistent follow-through are key. Please enjoy this self-healing podcast. IMPORTANT NOTE: We understand that some may believe mind-body healing is impossible. Therefore, if you would like to see images of individuals using their minds to relieve pain, you can check out this medical journal. It includes images from some of Brandy's case studies. If you want to learn how to use your mind to heal yourself, you can check out the training on Brandy's website. Each week, Brandy publishes a volunteer episode where she coaches a volunteer to heal themselves using their own mind. In addition, Brandy shares a quick IQ episode (Insights and Questions) where she answers listener questions or delves deeper into insights on working with the mind for healing. Additional links and resources: Click here to begin "Finding the GIFT in Self-Healing™" https://brandygillmore.com/healing Join the FREE Breakthrough 90-Minute "GIFT Mind-Body Healing™ Masterclass" Training: https://brandygillmore.com/gift-mind-body-healing-masterclass The GIFT Method™ Online Video Series: Heal Yourself. Change Your Life. https://brandygillmore.com/gift-method-healing Website: https://brandygillmore.com TEDx Talk: https://brandygillmore.com/tedx Social Media and Additional: Facebook: https://facebook.com/brandy.gillmore/ IG: https://www.instagram.com/brandygillmore/ X ~ (Twitter): https://twitter.com/BrandyGillmore Additional classes and services: Heal & Transform Your Self-Love and Relationships with GIFT Alternative Therapy and Mind-Reprogramming (GIFT ATMR)™:  https://brandygillmore.com/gift-atmr Gillmore Internal Freedom Technique (GIFT)® : https://brandygillmore.com/gillmore-internal-freedom-technique/ Additional Courses: https://brandygillmore.com/courses-workshops VIP Monthly Coaching https://brandygillmore.com/vip-coaching/ Please remember that genuine change and follow through are key for self-healing results. If you struggle with negative thoughts or have a chronic health issue or chronic pain, please do not avoid seeing your doctor. Instead, your goal with self-healing should be to continue to see your doctor as recommended and blow their mind with what you are capable of with your mind and with the power of mind-body healing. Please enjoy this self-healing podcast. Topics: relationship healing, how to improve relationships, emotional triggers in relationships, mind-body connection, creating love and connection, relationship advice for healing, practical relationship tips, energy in relationships, healing relationships with mindset, stop relationship patterns, mind-based relationship tools, relationship transformation tips, Brandy Gillmore, Brandy Gillmore relationship advice, self-healing and relationships, communication in relationships, improve relationship connection, relationship mindfulness, break negative relationship cycles

It is this combination of praise and word that will inflict vengeance and punishment on the enemies of our lives and our destinies

Scott Jagow joins Chris and Amy in-studio. He's recovering from recent shoulder surgery following a nasty fall last winter. He previews his 'Roaming St Louis' segment after a visit to a new, local Venezuelan restaurant. Listen to Total Information AM - Weekend.

Andy and Randy talk about Jessie Bates and Leonard Floyd being paired with guys like Xavier Watts, Billy Bowman, James Pearce, and Jalon Walker, and how that balance can create strong defenses sometimes.

In this episode of Let's ComBinate: Drugs + Devices, we welcome back Susan Neadle, author of The Combination Products Handbook. Susan explores the persistent and evolving challenge of terminology in combination products—a problem that continues to create confusion and regulatory risk even in 2025.Susan emphasizes the need for alignment on terminology and regulatory expectations, highlighting that true progress requires a science- and risk-based perspective. The discussion also covers how GMP requirements are interpreted differently in pharma versus medtech, the ongoing challenges of global harmonization, and why cohesive language is essential for compliance, inspection readiness, and effective product development.Episode Chapters00:00 Introduction and Welcome00:25 The Lexicon Problem in Drug-Device Combination Products01:01 Historical Efforts and Challenges02:12 Regulatory Frameworks and Definitions04:47 Industry and Regulatory Alignment Issues06:55 Science and Risk-Based Perspectives10:08 Terminology and Definitions in Practice14:05 Global Regulatory Differences17:22 Challenges in Harmonizing Standards23:13 Key Terms and Their Impact32:23 Conclusion and Contact InformationSusan Neadle is a recognized international Combination Products, Medical Device, and Digital Health expert with over 35 years industry experience. She has just published “The Combination Products Handbook: A Practical Guide” through Taylor & Francis Group/Routledge/CRC Press. Her leadership, innovation, and best practices have been recognized with several awards, including the 2022 ISPE Joseph X. Philips Professional Achievement Award for extraordinary contributions to the industry; 2021 TOPRA Award Finalist for Regulatory Affairs Excellence; and the Johnson Medal, Johnson & Johnson's highest honor for excellence in Research & Development. Susan retired from a distinguished and impactful career at Johnson & Johnson and is now Principal Consultant at Combination Products Consulting Services LLC, providing international quality, regulatory affairs, and design excellence services, to the biopharma, biotech, and medical device industries. She continues to fulfill her passion in this space as Chair of the ISPE Combination Products CoP, and Lead Author in Combination Products Working Groups through ASTM International and AAMI standards committees. Susan teaches curricula in Combination Products through UMBC, AAMI, and DIA, as well as customized training upon request. She is also active in multiple industry working groups including CPC, AFDO/RAPS, DIA, TOPRA and PQRI, and enjoys speaking at a variety of industry forums. Susan can be reached at sneadle@combinationprod.com Subhi Saadeh is a Quality Professional and host of Let's Combinate. With a background in Quality, Manufacturing Operations and R&D he's worked in Large Medical Device/Pharma organizations to support the development and launch of Hardware Devices, Disposable Devices, and Combination Products for Vaccines, Generics, and Biologics. Subhi serves currently as the International Committee Chair for the Combination Products Coalition(CPC) and as a member of ASTM Committee E55 and also served as a committee member on AAMI's Combination Products Committee.For questions, inquiries or suggestions please reach out at letscombinate.com or on the show's LinkedIn Page.

The U.S. is running out of options to service the national debt. Secretary Bessent announced that we will now use revenue from tariffs to pay down budget deficits, rather than reinvest them into the economy. Some are treating this as welcome news. At the same time, the GOP has formed a working group to draft up a “sequel” to the Big Beautiful Bill to deepen cuts to Medicaid and federal student aid. They’ll do anything other than raise taxes on those that can afford them. But tariffs and more cuts to vital programs will only hasten economic decline, so team Trump is running out of options to stop the bleeding. And that means only one thing: Printing more money. But that’s more complicated than it seems and will lead to disastrous results. It does explain, however, why Trump is so desperate to take over the Federal Reserve. Chapters Intro: 00:00:57 Post Show Musings: 00:32:55 Outro: 00:47:04 Resources UNFTR.com Sign the Petition To Stop the Senate From Passing These Bills Politico: House Republicans want another megabill. One GOP senator says it could be ‘damaging.’ X: Republican Study Committee Republican Study Committee: One Big Beautiful Sequel: RSC Chairman Launches Working Group for Second Reconciliation Bill Brookings: What is the repo market, and why does it matter? St. Louis Fed: What Is Yield Curve Control? Treasury: Treasury Announces Marketable Borrowing Estimates UNFTR Quickies UNFTR Discord -- If you like #UNFTR, please leave us a rating and review on Apple Podcasts and Spotify: unftr.com/rate and follow us on Facebook, Bluesky, TikTok and Instagram at @UNFTRpod. Visit us online at unftr.com. Join our Discord at unftr.com/discord. Become a member at unftr.com/memberships. Buy yourself some Unf*cking Coffee at shop.unftr.com. Visit our bookshop.org page at bookshop.org/shop/UNFTRpod to find the full UNFTR book list, and find book recommendations from our Unf*ckers at bookshop.org/lists/unf-cker-book-recommendations. Access the UNFTR Musicless feed by following the instructions at unftr.com/accessibility. Unf*cking the Republic is produced by 99 and engineered by Manny Faces Media (mannyfacesmedia.com). Original music is by Tom McGovern (tommcgovern.com). The show is hosted by Max and distributed by 99.Support the show: https://www.unftr.com/membershipsSee omnystudio.com/listener for privacy information.

Get My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/

Today, I'm taking you on a solo exploration into the world of extra virgin olive oil—a topic that's both well-loved in ancestral diets and increasingly backed by cutting-edge science. Inspired by my recent interview with TJ Robinson of the Fresh Pressed Olive Oil Club, I started looking deeper into what makes extra virgin olive oil so powerful for health and longevity. What I found truly surprised me: there's a wealth of research showing just how crucial high-quality olive oil is to the benefits of the Mediterranean lifestyle. Try the Fresh Pressed Olive Oil Club and get a $39 bottle of extremely fresh olive oil for just $1 for shipping. No catch, no subscription required. Go to GetFreshLongevity.com   Resources from the episode: Bioactive Compounds and Quality of Extra Virgin Olive Oil Protective Effects and Benefits of Olive Oil and Its Extracts on Women's Health EVOO's Effects on Incretin Production: Is There a Rationale for a Combination in T2DM Therapy? Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil FREE Peptide Book: natniddam.com/free   What we discuss: Mediterranean diet and lifestyle overview ... 00:04:30 What makes olive oil "extra virgin" ... 00:08:15 Key bioactive compounds in olive oil ... 00:12:03 Major health benefits and research highlights ... 00:19:10 GLP-1 activation, gut, and heart health ... 00:20:17 Olive oil's role in women's health and longevity ... 00:21:28 Ways to use extra virgin olive oil ... 00:24:16 Final tips and episode close ... 00:28:39   Our Amazing Sponsors: Berberine Breakthrough by BiOptimizers - Take 15 min. before a meal and your body will push carbs and glucose into your muscles to be used as fuel instead of turning them into fat. Enjoy more stable energy without the post-meal crash. Visit bioptimizers.com/bionat and enter the code BIONAT to get 10% off your order.   More from Nat:  YouTube Channel Join My Membership Community Sign up for My Newsletter  Instagram  Facebook Group

Utah Jazz play-by-play voice David Locke joined DJ & PK for his weekly visit to talk about Lauri Markkanen, the Utah Jazz, NBA expansion and helping DJ navigate basketball reference.

Got Questions?⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ https://calendly.com/conrad-rodriguez/30-minute-coaching-session⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Get THE BEST PENIS EXTENDER ON THE MARKET! ⁠⁠⁠⁠⁠⁠⁠⁠⁠CLICK HERE⁠⁠⁠⁠⁠⁠⁠⁠⁠

In this episode of Let's Combinate, host Subhi Saadeh is joined by long-time friend and Senior Technical Program Manager Joey Frechin, who brings a wealth of experience in med tech consulting. They discuss the intricacies of risk assessments for medical devices and drugs, focusing on differences and improvements in methodologies over the years. Joey shares insights on the challenges of aligning risk processes across different organizations and the importance of adaptable strategies. He also recounts his unique career path that blends design engineering with extensive process and risk management expertise. The conversation covers trends such as the shift toward off-the-shelf platforms and the balancing act between innovative design and market readiness. Joey emphasizes the value of stepping into roles and tasks that others may overlook, which has been key to his professional growth.00:00 Welcome and Introduction00:49 Discussing Risk Assessments in Med Tech04:34 Challenges in Aligning Risk Processes09:44 Understanding P1 and P2 in Risk Management12:55 Joey's Career Journey and Strategic Choices24:12 Trends in Combination Product Design31:48 Conclusion and Where to Find JoeyJoey Frechin is a technical program lead in the medical device and combination product development space.https://www.linkedin.com/in/joey-frechinSubhi Saadeh is a Quality Professional and host of Let's Combinate. With a background in Quality, Manufacturing Operations and R&D he's worked in Large Medical Device/Pharma organizations to support the development and launch of Hardware Devices, Disposable Devices, and Combination Products for Vaccines, Generics, and Biologics. Subhi serves currently as the International Committee Chair for the Combination Products Coalition(CPC) and as a member of ASTM Committee E55 and also served as a committee member on AAMI's Combination Products Committee.For questions, inquiries or suggestions please reach out at letscombinate.com or on the show's LinkedIn Page.

More on /ae/ + N: https://youtu.be/dYEbSmjA6YQJoin the free group to share audio files on streams: https://t.me/+TJTAfM5tEyQ1ODMxOR get feedback every single day: www.fluentamerican.com/telegramOne immediate way to start sounding natural is to analyze how you sound in American English. The reality is many American English learners are not saying words in a way that sounds natural, often creating a rhythm that does sound natural because it has little to no variation in contrast, in addition to issues with placement, breath, and vowels. Let's show you some quick techniques will have you start sounding natural in American English pronunciation. Welcome back to the Schwa Mill❗❗❗❗❗❗JOIN our channel to get access to our Pronunciation Group on Telegram, where you receive feedback and suggestions for YOUR pronunciation every day. See what it is like here: https://youtu.be/FDwPuwstUEoWho am I? My name is Geoff Anderson. I got my MA in Teaching English as a Second Language in 2012, and have been teaching since 2010. I've studied Italian to around level C1-C2. I was also an IELTS examiner for the speaking/writing tests for 3 years.Want to know what classes with me are like? Check out our Mission: English program, where we do livestreams that YOU can join Monday through Friday! It'd be great to do pronunciation exercises with you, answer your American English accent questions, and improve together in our supportive community; see what a Mission: English class is like here: https://www.youtube.com/playlist?list=PLlZ0dlSbrSXhxuga9nOujvx6FL9LU22h7#wakeupamerican #fluentamerican #americanenglish

Cellulite is one of the most common concerns we see in the world of aesthetics — but there's a lot of misinformation about what causes it and how to address it. In this episode of Plastic Surgery Untold, we're breaking down the truth about cellulite, how it relates to modern BBL trends, and why it's not just a “being out of shape” issue. From understanding the complex web of fibrous bands beneath the skin to exploring the role of hormones, skin laxity, and volume changes, we're covering the anatomy of cellulite and the latest treatment options that actually work. Whether you're dealing with dimples on the butt, thighs, or both, this conversation is packed with insights to help you target the root cause and get results you love. Highlights from this episode: • What cellulite actually is and why it happens • The difference between cellulite, skin laxity, and volume changes • Why targeted treatment is key for lasting results • How non-surgical office procedures can transform the contour of the butt and legs • Combination approaches that address all three concerns for the best outcome Listen anywhere you get your favorite podcasts or watch on YouTube for visuals and case examples.

Brazilian butt lifts have been one of the most transformative procedures in aesthetics, and with new technology, they're safer than ever. In this episode of Plastic Surgery Untold, we're breaking down how the combination of advanced anatomical understanding and ultrasound guidance has completely changed the game for BBL safety and results. A BBL offers powerful total-body transformation — subtracting fat from areas like the abdomen or love handles, and adding it to the hips and buttock for enhanced curves. In recent years, the focus has shifted from simply increasing size to creating shape, balance, and athletic definition. Key factors in today's BBL approach: Ultrasound guidance for precise, real-time fat placement in safe compartments Shape over size for a fit, natural look that complements the whole body Combination treatments like skin tightening, cellulite reduction, and targeted fat transfer for complete contouring By staying above the muscle and placing fat only in fat compartments, modern BBLs avoid dangerous complications while achieving smooth, shapely results. Whether paired with tummy tucks, rib contouring, or skin tightening, this evolution in technique means patients can look as good as they feel. Listen to the full episode on Plastic Surgery Untold wherever you get your favorite podcasts — and see why the BBL remains one of the most in-demand procedures today.

In our exclusive interview, Dr Élez discussed recent data comparing nivolumab (Opdivo) monotherapy with nivolumab plus ipilimumab (Yervoy) across multiple lines of therapy in patients with MSI-H mCRC. She detailed efficacy and quality‑of‑life outcomes, noting that the combination appeared to offer enhanced clinical benefit without a negative effect on tolerability. Dr Élez also highlighted the importance of tailoring immunotherapy strategies based on patient characteristics and treatment goals and reflected on the nuances of sequencing single‑agent vs combination checkpoint blockade.

Scared of missing out on the growth rally? Tracey Ryniec, Zacks Value Stock Strategist, screened for cheap stocks with growth. (0:30) - Stock Screener: Can You Find Strong Value Stocks With Growth? (6:45) - Tracey's Top Stock Picks (22:25) - Episode Roundup: ADDYY, ARRY, NX

Scared of missing out on the growth rally? Tracey Ryniec, Zacks Value Stock Strategist, screened for cheap stocks with growth. (0:30) - Stock Screener: Can You Find Strong Value Stocks With Growth? (6:45) - Tracey's Top Stock Picks (22:25) - Episode Roundup: ADDYY, ARRY, NX Podcast@Zacks.com

Stay up to date with the latest on combination therapies for weight reduction presented at ADA 2025.   Credit available for this activity expires: 7/28/2026 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/1002750?ecd=bdc_podcast_libsyn_mscpedu

Jim Clark, the voice of the Akron Rubberducks, joins Baskin and Phelps to break down Cleveland's newest acquisition Khal Stephen. He says Stephen reminds him a great deal of Shane Bieber and thinks he'll have a chance to contribute to the big league club in 2026.

In this episode of Let's Combinate, host Subhi Saadeh is joined by Mark Burchnall, Director of Engineering at PSN Labs, to break down the evolving role of mechanical modeling and simulation in medical device and combination product development.Mark, an expert in mechanical modeling & finite element analysis (FEA) and a licensed professional engineershares how modeling can dramatically reduce prototyping cycles, support regulatory submissions, and lower test burden when applied appropriately.Mark disucsses:Why modeling is often misunderstoodWhen it can replace (or complement) traditional testingWhat makes a model “credible” under ASME V&V 40How to build internal processes for regulatory-grade modelsAnd what every skeptic (or startup) needs to know before adopting modeling⏱️ Timestamps:00:00 Introduction and Guest Welcome00:17 Mark's Expertise in Mechanical Modeling01:28 Subhi's Foundational Experience04:09 The Importance of Modeling in Engineering05:44 Challenges and Misconceptions in Modeling10:52 Life Cycle and Inputs of a Model16:21 Types of Models and Their Applications17:49 Numerical Solvers and Sensitivity Analysis21:28 CAD, Fluid Properties, and Starting a Model22:00 Defining the “Question of Interest”23:21 Modeling Cycle and Initial Steps24:35 Verification and Validation in Modeling25:40 Assessing Model Risk and Credibility31:43 Regulatory Guidelines and Industry Practices39:15 Implementing Modeling in Product Development42:17 Conclusion and Contact InformationMark is a product development consultant with over 15 years of experience in the Medical and Combination device sectors. As the Director of Engineering at PSN Labs, Mark leads the engineering department, offering invaluable support to clients in new product development, computational modeling and simulation, test method development, functional prototyping, contract manufacturing, and on-market remediation. His team specializes in designing devices that incorporate various design principles, including manufacturing, assembly, sustainability, biocompatibility, reprocessing, and reliability. Mark's background encompasses the development of innovative healthcare solutions in areas such as drug delivery, surgical robotics, pharmaceutical packaging, and catheters. His expertise ensures patient safety and regulatory compliance throughout the design process. Mark holds a Bachelor of Science in Mechanical Engineering from Purdue University and a Master of Science in Mechanical Engineering from the University of Cincinnati.Subhi Saadeh is a Quality Professional and host of Let's Combinate. With a background in Quality, Manufacturing Operations and R&D he's worked in Large Medical Device/Pharma organizations to support the development and launch of Hardware Devices, Disposable Devices, and Combination Products for Vaccines, Generics, and Biologics. Subhi serves currently as the International Committee Chair for the Combination Products Coalition(CPC) and as a member of ASTM Committee E55 and also served as a committee member on AAMI's Combination Products Committee.For questions, inquiries or suggestions please reach out at letscombinate.com or on the show's LinkedIn Page.

Come to a Dehoarding Accountability Zoom Session: http://www.overcomecompulsivehoarding.co.uk/ticket Subscribe to the podcast: https://www.overcomecompulsivehoarding.co.uk/subscribe Podcast show notes, links and transcript: http://www.overcomecompulsivehoarding.co.uk/  Why is it so hard to deal with uncertainty, and what does that have to do with hoarding? This week I'm joined by Dr Jan Eppingstall to unpack how our brains handle ambiguity, why fear of making mistakes can keep us stuck, and how intolerance of uncertainty feeds into hoarding behaviours. We break down practical ways to build up your tolerance for not knowing and share some strategies that might actually make a difference. Uncertainty and Its Challenges Definition and context of uncertainty Evolutionary reasons for discomfort with uncertainty (Selfish Brain Theory) Contrast between historical resource scarcity and modern abundance Our minds' outdated ways of managing uncertainty Cognitive Closure What is cognitive closure? Difference between cognitive closure (psychological need for definite answers) and “closure” in pop culture (emotional resolution) How it relates to need for certainty in present/future, not just past events The creation of cognitive closure measurement scales by researchers Factors influencing need for cognitive closure: Personality traits: Conscientiousness, neuroticism (now called emotionality), openness to experience, extroversion Trauma history and its effects on the nervous system Neurodivergence (with emphasis on autism and “sticky thinking”) Combination of personality, trauma, and neurodivergence Intolerance of Uncertainty Psychological definition of intolerance of uncertainty Negative cognitive bias: How it affects perception and response Manifestations in people experiencing uncertainty as distress Its direct relevance to hoarding behaviours The Link Between Hoarding Disorder and Intolerance of Uncertainty Research findings: intolerance of uncertainty as a predictor of hoarding symptom severity Usefulness in early intervention strategies intolerance of uncertainty as a transdiagnostic factor (across anxiety, some depression, and other mental health conditions) How heightened anxiety sensitivity in hoarding perpetuates avoidance Experiential avoidance in hoarding (saving and acquiring behaviours) Connection between maladaptive behaviours and intolerance of uncertainty Fear of Making Mistakes and Perfectionism Common fears of mistakes in hoarding (disposing, acquiring, putting things away) Perfectionism's role (fear of failure, not wasting) All-or-nothing thinking and rigid decision-making rules Paralysing effect of avoidance due to fear of mistakes Not making a decision as a potential mistake itself Interaction and reinforcement between perfectionism and intolerance of uncertainty Comorbidity and Severity Research on multiple diagnoses: More than half of psychiatric patients have more than one diagnosis Diagnostic challenges and overlapping criteria How comorbidity compounds issues: More symptoms and more complexity Higher intolerance of uncertainty linked with more severe hoarding, especially when other conditions are present Impact on treatment difficulty intolerance of uncertainty's Impact on Acquiring and Discarding Behaviours How acquiring reduces fear of missing out and future needs Difficulty discarding as protection against future regret Shame around mistake-making Common inner questions: Future use, responsibility, relationships More complexity leading to more avoidance Nuances in intolerance of uncertainty and Hoarding Study on sub-factors of uncertainty: Factor 1: Negative self-referential implications (linked to hoarding severity) Factor 2: Perception of uncertainty as unfair (not linked) Internal vs. external perspectives on uncertainty Relevance of anxiety-driven self-criticism Changing Relationship to Uncertainty: Curiosity and Reframing Rilke's quote on “loving the questions” Transforming approach from fear to curiosity Curiosity as a therapeutic tool Creativity in imagining alternatives and solutions Relevance of loss aversion and cognitive biases Modern Life and Uncertainty Intolerance Research linking increased use of technology (instant answers) to rising intolerance of uncertainty Smartphone/information overload and decreased tolerance “muscle” Relevance to hoarding (desire for backups, information saving) Example: IMDb, screenshots, saving digital info Treatment Strategies Cognitive Behavioural Therapy (CBT) effects on intolerance of uncertainty in anxiety Acceptance and Commitment Therapy (ACT) and exposure-based methods: Pros and cons Importance of a therapist experienced in error-related distress and uncertainty Key skills: Observing distress, sitting with uncomfortable feelings, gradual exposure Self-help approaches: Reframing mistakes as learning Practicing self-compassion Values-based decision-making Systematic exposure to small errors Gradually breaking rigid rules (e.g., waste, tidiness) Recognising individual differences and seeking appropriate support Embracing Mistakes and Humanity Learning from therapist/client anecdotes Cultural expectations around perfectionism vs. real human messiness How mistakes can be positive or even entertaining Letting go of the need for perfection The Four Cs for Managing Uncertainty From Elizabeth Weingarten: Curiosity, Conversation, Community, Commitment How to foster each: Curiosity: Approach with questions and exploration Conversation: Discuss uncertainties with trusted people Community: Build social support Commitment: Dedication to exploring questions and knowing when to let go Links Hillman, S. R. HOARDING DISORDER AND Intolerance of Uncertainty, Anxiety Sensitivity and Distress Tolerance in Hoarding Disorder Compared to OCD and Healthy Controls - Shemariah R. Hillman; Claire L. Lomax; Nadeen Khaleel; Theresa R. Smith; James D. Gregory Baldwin, P. A Multimethod Examination of Vulnerability in Hoarding, UNSW Sydney, 2016. https://doi.org/10.26190/UNSWORKS/19156 Castriotta, N.; Dozier, M. E.; Taylor, C. T.; Mayes, T.; Ayers, C. R. Intolerance of Uncertainty in Hoarding Disorder. Journal of Obsessive-Compulsive and Related Disorders 2019, 21, 97–101. https://doi.org/10.1016/j.jocrd.2018.11.005 Exploring Humanity's Relationship to Uncertainty with Elizabeth Weingarten  Podcast ep 49: Sitting with discomfort: distress tolerance and hoarding – How unconscious distress avoidance might be worsening your problems Podcast ep 190: What if we forgive ourselves, but now we know better, we do better? Choosing compassion over shame in hoarding disorder Podcast ep 182: What are “towards and away moves” and what on earth do they have to do with hoarding recovery? With Dr Jan Eppingstall Podcast ep 127: Overcoming overspending with Paige Pritchard, Money Coach Come to a Dehoarding Accountability Zoom session: Accountability Booking Form Dr Jan Eppingstall at Stuffology https://www.facebook.com/stuffologyconsulting/ https://twitter.com/stuff_ology https://www.instagram.com/stuff_ology/ Dr Jan Eppingstall on Pinterest Website: Overcome Compulsive Hoarding Become a Dehoarding Darling Submit a topic for the podcast to cover Questions to ask when dehoarding: https://www.overcomecompulsivehoarding.co.uk/podquestions Instagram: @thathoarderpodcast Twitter: @ThatHoarder Mastodon: @ThatHoarder@mastodon.online TikTok: @thathoarderpodcast Facebook: Overcome Compulsive Hoarding with That Hoarder Pinterest: That Hoarder YouTube: Overcome Compulsive Hoarding with That Hoarder Reddit: Overcome Compulsive Hoarding with That Hoarder subreddit Help out: Support this project Sponsor the podcast Subscribe to the podcast Subscribe to the podcast here

The Broncos haven't had a quarterback/head coach combo in consecutive years since 2014, until now. How lethal is the Payton-Nix duo? And is it true that almost all great QB's have great head coaches as well and vice versa? In Year 3 of the Sean Payton era, are the Broncos on schedule? Plus, a look at the early portion of the Broncos 2025 schedule. And if you could choose a 'homegrown duo' from the Broncos, which two players would you go with - active players and an all-time duo? Eric Goodman and Bruce Haertl are back after the weekend on Hot Takes!

In this episode, Joseph W. Franses, MD, PhD; Neehar Parikh, MD, MS; and Mark Yarchoan, MD, share their thoughts on incorporating immune checkpoint inhibitors into the care of patients with HCC including:Clinical Considerations for Selecting First-line Immunotherapy Combinations for Metastatic HCCOverview of the Latest Data for the Combination of TACE With Immunotherapy (eg, EMERALD-1 Study of TACE and Durvalumab ± Bevacizumab for Unresectable HCC; and LEAP-012 Study of TACE + Lenvatinib + Pembrolizumab) Latest Clinical Data and Updates for Systemic Therapy in Patients With High-Risk Early HCCProgram faculty:Joseph W. Franses, MD, PhDAssistant Professor of MedicineSection of Hematology-OncologyUniversity of ChicagoChicago, IllinoisNeehar Parikh, MD, MSAssociate ProfessorLi Ka Shing Research Professor of HepatologyClinical Director of HepatologyMedical Director, Liver Tumor ProgramDivision of Gastroenterology & HepatologyUniversity of MichiganAnn Arbor, MichiganMark Yarchoan, MDAssociate ProfessorSidney Kimmel Comprehensive Cancer CenterJohns HopkinsBaltimore, Maryland Resources:To access the resources associated with this podcast discussion, please visit the program page to access a recording from a live webinar and a frequently-asked questions commentary on this topic.

  At a time in which our nation continues to experience the regular horror of school shootings, it's understandable that everyone grasps for ideas – anything – that seems like it might prevent or reduce the terrifying carnage. The gruesome notion of a disturbed killer gunning down innocent children is enough to make anyone wish […]

Optimiza tu LDL Colesterol e interpreta tu analítica o las de tus pacientes hoy, sin fármacos, aplicando estrategias nutricionales y suplementos clave con dosis y ciencia. Accede aquí:https://philhugo.com/producto/ldl-colesterol/  ¡Te espero dentro!Los suplementos be levels mencionados que formulo personalmente: Tu código de descuento: INTERGALACTICOBerberina: https://shop.belevels.com/products/berberine?sca_ref=745165.uf0cpcacla Omega 3: https://belevels.com/products/omega3?sca_ref=745165.uf0cpcaclaTriple Magnesio: https://belevels.com/products/magnesium?variant=47417739379012.uf0cpcacla Dosis y los demás explicados en el curso de Control Absoluto del LDL Colesterol.¿Sigues una dieta cetogénica estricta y tu LDL se ha disparado a niveles que asustarían a cualquier médico? No estás solo. En este episodio, desentrañamos la fisiología del Lean Mass Hyperresponder (LMHR): un perfil metabólico donde el colesterol LDL se eleva no por enfermedad, sino por eficiencia energética. Aprende cómo tu hígado, en ausencia de glucosa, convierte grasa en combustible a través de VLDL y LDL. Descubre por qué un LDL de 300 mg/dL puede ser normal si tu HDL está alto, tus triglicéridos bajos y tu inflamación es cero. Estudio a estudio, desmonto los miedos injustificados y propone estrategias clínicas reales para modular tu LDL si es necesario, desde el aumento de carbohidratos limpios hasta la optimización tiroidea y muscular. Este episodio no es para quien se conforma con los rangos de laboratorio estándar. Es para quien quiere entender su cuerpo desde la lógica metabólica y tomar decisiones con ciencia, no con miedo.ReferenciasApoB es biomarcador y posible diana terapéutica cardiovascular. Behbodikhah, Jennifer et al. “Apolipoprotein B and Cardiovascular Disease: Biomarker and Potential Therapeutic Target.” Metabolites vol. 11,10 690. 8 Oct. 2021LDL sube mucho en "lean mass hyper-responders" con dieta baja en carbohidratos. Norwitz, Nicholas G et al. “Elevated LDL Cholesterol with a Carbohydrate-Restricted Diet: Evidence for a "Lean Mass Hyper-Responder" Phenotype.” Current developments in nutrition vol. 6,1 nzab144. 30 Nov. 2021Marcadores tiroideos y composición corporal predicen cambios en LDL con dieta cetogénica. Cooper, Isabella D et al. “Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a ketogenic diet: experimental support for the lipid energy model.” Frontiers in endocrinology vol. 14 1326768. 21 Dec. 2023Omega-3 mejora dislipidemia en relación dosis-respuesta. Wang, Tianjiao et al. “Association Between Omega-3 Fatty Acid Intake and Dyslipidemia: A Continuous Dose-Response Meta-Analysis of Randomized Controlled Trials.” Journal of the American Heart Association vol. 12,11 (2023): e029512.Omega-3 de prescripción tiene efectos lipídicos beneficiosos. Bays, Harold E et al. “Prescription omega-3 fatty acids and their lipid effects: physiologic mechanisms of action and clinical implications.” Expert review of cardiovascular therapy vol. 6,3 (2008): 391-409La berberina reduce lípidos, sola o combinada. Koppen, Laura M et al. “Efficacy of Berberine Alone and in Combination for the Treatment of Hyperlipidemia: A Systematic Review.” Journal of evidence-based complementary & alternative medicine vol. 22,4 (2017): 956-968.Niacina baja lipoproteína(a) según fenotipo de apo(a). Artemeva, N V et al. “Lowering of lipoprotein(a) level under niacin treatment is dependent on apolipoprotein(a) phenotype.” Atherosclerosis. Supplements vol. 18 (2015): 53-8

Scheim does the news: Sharks and flooding are becoming a problem // Mego talks Celtics' financial strategies, going after Lillard // Diabetes Barbie and automatic bike washing is a thing //

In this week's episode, we'll learn about rapid, high-sensitivity diagnostic assays for TTP, or thrombotic thrombocytopenic purpura, that can reduce unnecessary treatments. After that: enhancing PD-1 blockade in relapsed/refractory extranodal NK/T-cell lymphoma. In a single-arm, phase 2 study, combined CD38 and PD-1 inhibition demonstrated durable responses and manageable safety. Finally, a lymphoma horror story with a happy ending. CREBBP mutations create a zombie enzyme that competes with its wild-type counterparts. By enforcing CD40 signaling, a bispecific antibody overcomes this effect and induces lymphoma cell death.Featured Articles:Rapid ADAMTS13 activity assays for thrombotic thrombocytopenic purpura: a systematic review and meta-analysisEfficacy of combined CD38 and PD-1 inhibition with isatuximab and cemiplimab for relapsed/refractory NK/T-cell lymphomaBlunted CD40-responsive enhancer activation in CREBBP-mutant lymphomas can be restored by enforced CD4 T-cell engagement

Can Rowan Marshall and Tom De Koning work well together, or is getting TDK going to push Ro out the door? Supposedly Geelong, Adelaide and maybe even Carlton could look to prize him out of Moorabbin... for the right price. Hosted on Acast. See acast.com/privacy for more information.

LISTEN!!!

Bubblegum Noise, also known as the combination of Pink Noise and White Noise, creates a balanced, soothing soundscape. White Noise, with its broad frequency range, effectively masks disruptive sounds, promoting focus or sleep. Pink Noise, with its richer, more natural tones, emphasizes lower frequencies, creating a calming atmosphere. Together, they blend perfectly, offering an ideal environment for relaxation, concentration, or rest. This harmony provides a tranquil backdrop that helps mask distractions, promote mental clarity, and enhance relaxation. ❗ ❗ To support this podcast and unlock all the ad-free and intro-free episodes, along with other benefits, SUBSCRIBE at ⁠⁠https://12hourwhitenoise.supercast.com⁠⁠ ❗ ❗Although there may be an ad or two at the very beginning of this free episode, you can rest assured that there will be no further interruptions or ads once the Sleep Sound begins

Welcome to my podcast, The Wellness Project with Des, where I speak about all things mental health and wellness to bring you actionable tips you can implement in your own life to help improve your mental health and overall well-being.On today's episode, I speak with therapist Caitlan Siegenthaler about how she combines Internal Family Systems and Human Design in her practice. For detailed show notes and where to find Caitlan: accordingtodes.com/199Want to work together? Schedule your free 30-minute consultation call:https://calendly.com/thewellnessprojectwithdes/coaching-consultationShow your love and support for the podcast by buying me a cup of coffee: buymeacoffee.com/thewellnessprojectwithdesShop wellness and positivity products from my Redbubble store:https://www.redbubble.com/people/AccordingtoDes/shop?asc=uCheck out books and products written or recommended by my amazing podcast guests:https://www.amazon.com/shop/influencer-3be311d1?ref_=cm_sw_r_cp_ud_aipsfshop_aipsfinfluencer-3be311d1_GRVS2AR62H5TFFHR13RQBecome a part of my Facebook community: facebook.com/groups/accordingtodesFollow me on Instagram: instagram.com/thewellnessprojectwithdesFollow me on TikTok: tiktok.com/@therapywithdes.lcswI would greatly appreciate it if you would take a moment to leave a review for my podcast on iTunes and/or Spotify. Thank you! https://podcasts.apple.com/us/podcast/the-wellness-project-with-des/id1477570126

BUFFALO, NY – July 1, 2025 – A new #review was #published in Volume 16 of Oncotarget on June 17, 2025, titled “Optimizing enfortumab vedotin plus pembrolizumab therapy.” First authors Elias Antoine Karam of the Gustave Roussy and Saint-Joseph University of Beirut and Yaghi César Céline from the Saint-Joseph University of Beirut, along with their colleagues, reviewed recent developments about treating advanced urothelial carcinoma (aUC), an aggressive form of bladder cancer. Their review highlights how combining enfortumab vedotin and pembrolizumab as a first-line treatment offers a major improvement for patients with limited options and poor prognoses. Advanced urothelial cancer has traditionally been treated with platinum-based chemotherapy, which often causes serious side effects and offers limited long-term benefit. Many patients are even ineligible for it due to underlying health conditions. The new combination presents a more effective and better-tolerated alternative, as shown in recent clinical trials reviewed by the authors. Enfortumab vedotin targets Nectin-4, a protein present in most urothelial cancer cells, delivering a cancer-killing agent directly into tumors. Pembrolizumab helps the immune system detect and destroy cancer cells. Together, they have shown strong results in extending survival with fewer serious side effects than chemotherapy. These findings led to FDA approval in 2023 for use in a broad range of patients, including those unable to tolerate traditional treatments. “In the phase II KEYNOTE-052 study, pembrolizumab demonstrated significant efficacy as initial therapy in patients with aUC who were ineligible for a cisplatin-based regimen.” The review also compares this new approach with other evolving strategies, such as therapies using nivolumab and chemotherapy combinations. Among current first-line options, enfortumab vedotin and pembrolizumab have produced the most promising outcomes. However, the best course of action following disease progression remains unclear. Other important challenges raised in the review include the high cost of the new therapies, limited patient access to them, and the absence of reliable biomarkers to predict individual response. The authors call for further studies to refine treatment strategies and explore blood-based tools that could guide therapy decisions and minimize side effects. This review offers a clear summary of how recent clinical advances are reshaping the treatment of aUC. It reflects a shift away from traditional chemotherapy toward immunotherapy and targeted, personalized treatments that aim to extend survival and improve quality of life. DOI - https://doi.org/10.18632/oncotarget.28741 Correspondence to - Elias Antoine Karam - eliaskaram18@gmail.com Video short - https://www.youtube.com/watch?v=VrTXaF2qW2k Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28741 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, advanced urothelial carcinoma (aUC), enfortumab vedotin, pembrolizumab, treatment strategies, bladder cancer To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

❗ ❗UPDATE ❗ ❗Per listener request, I've updated the name of this episode

If you could take two pills (once a week) and live 30% longer, would you? Because a study on mice using drugs approved for humans suggests you may have to answer this question soon.

The Bishop Score was originally developed in 1964 by Dr. Edward Bishop and remains the central assessment tool for determining the appropriateness of cervical ripening for labor induction. We have covered pharmacologic and mechanical methods of cervical ripening for labor induction many times in prior episodes. Ut now, in July 2025, there will be a new clinical practice guideline (#9) from the ACOG which has some notable items. Does the ACOG recognize COMBINATION mechanical and pharmacologic agents for cervical ripening for labor induction? What about outpatient cervical ripening? What are the recommended protocols for oral and vaginal prostaglandins? Listen in for details.

This week, Chitra Eder and I discussed how massage is perceived in Ayurveda and TCM, different massage practices, and benefits for women in perimenopause and menopause.If you are interested in learning more about how these traditional forms of medicine can support your menopause journey, then join us live every Thursday for more conversations.Do check out Chitra's upcoming Ayurvedic Solstice Workshop happening this Saturday.Stay tuned for more information on my upcoming Rebalance & Restore: Menopause Support Through the Combination of Traditional Chinese Medicine & Essential Oils This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit clarissakristjansson.substack.com

In this episode of RCA Radio, host Brandon Miller sits down with Jessica Schafersman, a design and development expert at RCA®, to break down the increasingly complex world of combination products—those that blend drugs, devices, or biologics. Jessica shares insights on why these products are uniquely challenging, the regulatory expectations companies must meet, and how the FDA guidance that is intended to make the submission process streamlined. From design controls and quality system integration to the importance of human factors validation and international considerations, this episode is packed with practical advice for any company entering or expanding in the combination product space. 

What's on Craigslist? 6-16-2025 …Gay Man seeks Straight Woman for Family Picnic …Woman Seeks Man to Marry Immediately …Woman seeks Woman (Vomiting Okay) …It's a Combination, Brass Knuckles-Jesus/Taco Holder/Butt Plug

Dr. Casey Grover explores the history, neuroscience, and treatment approaches for methamphetamine use disorder, highlighting how methamphetamine releases more dopamine than any other known substance.• Methamphetamine was widely used during World War II by German, Japanese, and Allied forces to enhance performance• Modern meth production shifted from ephedra to P2P method, creating cheaper, more potent meth with worse psychiatric effects• Meth causes dopamine release up to 1,400 ng/dL of dopamine compared to cocaine (400), sex (200), and food (150), severely damaging reward centers• Many methamphetamine users have undiagnosed ADHD and are inadvertently self-medicating• Effective medications include bupropion, topiramate, atomoxetine, viloxazine, guanfacine, and mirtazapine• Contingency management (reward-based incentives) shows significant efficacy for methamphetamine addiction treatment• Combination therapies using bupropion with naltrexone show promise for reducing meth use• Treating underlying mental health conditions and providing housing/social support remains essential for recoveryTo contact Dr. Grover: ammadeeasy@fastmail.com

The side topic today for the 94 WIP Morning Show: what's the best combination of TV and movie role for example, Michael J. Fox as Marty McFly in Back to the Future as well as Alex P Keaton in Family Ties.

If you've ever wondered what a combination product is—or how to explain it—this video breaks it down clearly and simply. This is a non-technical, high-level explanation of what a combination product is. It's meant for anyone who works in or around pharma, medtech, or biotech and wants a clear, shareable reference—without getting into detailed regulatory definitions or region-specific nuances.I'm Subhi Saadeh, and I've spent my career in drug-device combination products. In this short reference video, I walk through:- What defines a combination product- Two key factors: primary mode of action and how components are combined- The difference between drug-led and device-led products- Examples of single-entity, co-packaged, and cross-labeled products00:00 Introduction to Drug Device Combination Products00:31 Defining Combination Products00:54 Philosophical Factors of Combination Products01:10 Drug-Led Combination Products01:51 Device-Led Combination Products02:32 Combination Configurations03:50 Summary and ConclusionAdditional Resources: - 21 CFR Part 4 FDA regulation on Current Good Manufacturing Practice (CGMP) requirements for combination products https://www.ecfr.gov/current/title-21/chapter-I/subchapter-A/part-4- FDA Guidance: Current Good Manufacturing Practice Requirements for Combination Productshttps://www.fda.gov/media/90652/download- FDA Combination Products Overview Page https://www.fda.gov/combination-products- 21 CFR Part 3 Regulations on combination product classification and primary mode of action (PMOA) https://www.ecfr.gov/current/title-21/chapter-I/subchapter-A/part-3- EU MDR Article 117 Requirements for drug-device combinations under the European Medical Device Regulation (Regulation (EU) 2017/745) https://health.ec.europa.eu/system/files/2021-10/md_mdr_2017-745_en_0.pdfSubhi Saadeh is a Quality Professional and host of Let's Combinate. With a background in Quality, Manufacturing Operations and R&D he's worked in Large Medical Device/Pharma organizations to support the development and launch of Hardware Devices, Disposable Devices, and Combination Products for Vaccines, Generics, and Biologics. Subhi serves currently as the International Committee Chair for the Combination Products Coalition(CPC) and as a member of ASTM Committee E55 and also served as a committee member on AAMI's Combination Products Committee.For questions, inquiries or suggestions please reach out at letscombinate.com or on the show's LinkedIn Page.

This week on The Game Marks Podcast we are playing Fire Pro Wrestling Combination Tag.  How does the first ever Fire Pro Wrestling game hold up!?Please subscribe and leave a review for this podcast on Apple Podcast and Spotify and follow us on all forms of social media @gamemarkspod.Join George Feis & Johnny Clash each week as they do a #DeepDive into the good, the bad & the awesome of wrestling video games. Do your favorite games stand the test of time or are you playing them with nostalgia goggles? New episodes every other Monday!SponsorsMad Cat Beard Care: madcatbeardcare.com GAMEMARKS for 15% offMerch: podxchange.shopPro Wrestling Tees: prowrestlingtees.com/gamemarkspodTee Public: teepublic.com/user/gamemarkspodWWE Shop: wwe-shop.sjv.io/Qj05r3

In this episode, the guys discuss who they'd take to the bar, followed by a deep dive into the recent House vs. NCAA settlement and its implications for college sports. The conversation shifts to the impact of NIL deals on player recruitment and team dynamics. Once they've settled that once and for all, they jump to the seriously impressive play surrounding the Stanley Cup and NBA Finals. You have to watch these two finals if you're a fan of sport.They jump into the introduction of Supio, a new AI platform for plaintiff law firms. Supio turns case documents into critical insights with the power of AI to help firms work smarter, settle bigger and win more in court.They celebrate Coco Gauff's rise in women's tennis, marking her as a significant figure in the sport. In this conversation, the hosts discuss various themes in sports, focusing on women's tennis rivalries, the current state of men's American tennis (while wondering where the American male tennis champions have all gone), and the impact of coaching changes in the NBA and NHL. Assembly Software is a huge part of how the guys keep this show going. It's known for its leading case management product, TrialWorks, and its cloud-based solution, Neos. Neos allows law firms to access everything on the road and now features an AI program to enhance efficiency in tasks like drafting letters. Check out AssemblySoftware.com for more information.Last, they go on a mission to figure out what is in the minds of the Pittsburgh Steelers' management, and examine their quarterback "situation". They preview the US Open golf tournament, highlight the excitement of the College World Series, and address fan behavior in tennis matches.And of course the show would not be complete without Injury Board, an exclusive networking and marketing firm that connects and refers cases among the best plaintiffs' lawyers in the country. If you're a leader in your community and at the bar, consider checking out InjuryBoard.org for membership and referral opportunities.And If you're looking for a company to develop your website and digital marketing, Digital Law Marketing offers exclusive regional partnerships, unlike other companies that might prioritize marketing competitors. Their proven results have led to significant increases in organic originations. Go to DigitalLawMarketing.com for details.

The principal theme of this podcast episode centres on the notion that mere job performance is insufficient for career advancement. I engage in a dialogue with Andrea Wasserman, founder of Executive Express, who elucidates the invisible rules that govern professional progression, particularly for new graduates. Andrea emphasizes the critical importance of communication and executive presence, asserting that individuals must actively showcase their achievements to cultivate recognition in increasingly competitive environments. Furthermore, we explore the concept of "style flexing," which entails adapting one's approach based on the dynamics of the workplace. This conversation serves as a vital resource for listeners seeking to enhance their influence and navigate the complexities of career development effectively.Links referenced in this episode:theexecutiveexpress.comlinkedin.com/in/andreawassermaninstagram.com/theexecutiveexpresstiktok.com/@theexecutiveexpresssubstack.com/@theexecutiveexpressWant help creating your own podcast? Visit us at podjunction.com or reach out to Sadaf directly on LinkedIn: https://www.linkedin.com/in/sadafbeynon/

• Intro• Xbox-Branded ROG Ally Leaks• SteamOS Game Verification Announced• The BACKLOG• Nintendo Gives Themselves Permission to Brick Your Switch• Switch 2 May Be Recording Your Audio and Voice Chats• Nintendo Estimates 15 Million Switch 2 Consoles Sold• 2025 Video Game Hall of Fame Inductees• Palworld Confirms Changes Due to Nintendo Lawsuit• Mafia: The Old Country Trailer and Release Details• Indiana Jones Now Steam Deck Verified• GTA VI Trailer a Combination of Cutscene and Gameplay• TWEET OF THE WEEK• Q&AOriginally streamed on May 13, 2025