Selection of items from a collection
Featuring a slide presentation and related discussion from Professor Arndt Vogel, including the following topics: Advances in first-line treatment for patients with advanced hepatocellular carcinoma (HCC) (0:00) Outcomes of Phase III clinical trials evaluating single-agent immunotherapy as initial treatment for advanced HCC (4:19) Immune checkpoint inhibitors as second-line treatment for recurrent HCC (6:03) Combination therapy as initial treatment for advanced HCC (8:05) Sequencing therapies for advanced HCC (13:20) Future directions in caring for patients with advanced HCC (22:43) CME information and select publications
Q&A: Most common client questions lately: Will I have to change my retirement goals or retirement income due to the down market? Short-term risk versus long-term risk, taxes, inflation, overspending Sequence of return risk... https://www.schwab.com/learn/story/timing-matters-understanding-sequence-returns-risk Worst year ever for bonds? https://www.advisorperspectives.com/articles/2022/10/17/six-good-things-to-tell-clients-about-this-horrible-market Article: “Six Good Things to Tell Clients About This Horrible Market” by Allan Roth, 10/17/2022. Four Options Plus Combo Option for Preparing for Potential Airline Disability Be ready to live on your maximum disability payout. Takes careful budgeting and cash flow management. For example: Be ready to freeze your “core” budget at FO pay. Or on one person's salary if you are a dual-income family. Create a (mega) Emergency Fund. Work to self-insure. Becoming your own insurance company! We believe the six-month emergency fund is the minimum for airline pilots. One year is even better. An emergency fund of cash or cash-like investments gives you great flexibility. It can bridge the gap until you are able to get your FAA medical back. If appropriate and cost-effective, purchase additional disability insurance. Consider how a long-term disability would affect your retirement savings. For example, if you can live on the current disability insurance your airline offers, would you also be able to save for retirement? Your retirement plan assumes annual savings into tax-advantaged retirement accounts. Become financially independent! This most likely applies to the pilots that are nearer to retirement. If they lost their FAA medical, then these folks could more easily transition into early retirement. On the other hand, this is a great goal for all pilots to shoot for as soon as possible. This step encompasses working on all the steps listed here as well as saving in your retirement accounts. Combination of 2 or more options 1-4. Additionally, we suggest exploring other skill sets that may allow for additional income away from aviation in the case of long-term disability. What do you love to do outside of flying? Have fun with it and dream a little! For example, become a financial planner! Pilots are much more marketable than they think.
One reason we like Charlie Munger is he rarely, if ever, minces words. (0:21) Bill Mann discusses: - The latest PPI data boosting the market - Walmart's inventory levels (and 3rd-quarter results) catching Wall Street's attention - Charlie Munger sounding off on crypto (13:37) Alison Southwick and Robert Brokamp dip into the Fool Mailbag to answer questions about Roth IRAs, how ETFs work, and more! Companies discussed: WMT, GE, UAA Host: Chris Hill Guests: Bill Mann, Alison Southwick, Robert Brokamp Producer: Ricky Mulvey Engineers: Dan Boyd, Rick Engdahl
November is Lung Cancer Awareness Month. This is an important time of the year, which brings the community together to help provide awareness, and people about the symptoms of the disease. It is the fifth most common cancer in Australia, with thousands of Australians diagnosed with the disease each year. The estimated number of new cases of lung cancer diagnosed in 2022 is 14,529 of which 7,707 are males and 6,822 are females. We speak with Dr Salah Amedi from Perth about lung cancer and its causes. - Mijdar Meha Hişyariya Penceşêra Pişikê ye. Ev demeke girîng ya salê ye, ku civakê digihîne hev da ku alîkariya peydakirina hişyariyê bike, û agahdar bike û mirovan li ser nîşanên nexweşiyê agahdar bike. Ew pêncemîn kansêra herî berbelav li Australya ye, ku her sal bi hezaran Australî bi vê nixweşiyê têne teşxîs kirin. Hejmara texmînkirî ya dozên nû yên seretana pişikê di sala 2022 de hatine tespît kirin evin 14,529 ku 7,707 nêrin û 6,822 mê ne. Em derbarê vê mijarê bi Dr Selah Amêdî re dipeyvin.
Ed's Links (Order RED ROOM!, Patreon, etc): https://linktr.ee/edpiskor Jim's Links (Patreon, Store, social media): https://linktr.ee/jimrugg ------------------------- E-NEWSLETTER: Keep up with all things Cartoonist Kayfabe through our newsletter! News, appearances, special offers, and more - signup here for free: https://cartoonistkayfabe.substack.com/ --------------------- SNAIL MAIL! Cartoonist Kayfabe, PO Box 3071, Munhall, Pa 15120 --------------------- T-SHIRTS and MERCH: https://shop.spreadshirt.com/cartoonist-kayfabe --------------------- Connect with us: Instagram: https://www.instagram.com/cartoonist.kayfabe/ Twitter: https://twitter.com/CartoonKayfabe Facebook: https://www.facebook.com/Cartoonist.Kayfabe Ed's Contact info: https://Patreon.com/edpiskor https://www.instagram.com/ed_piskor https://www.twitter.com/edpiskor https://www.amazon.com/Ed-Piskor/e/B00LDURW7A/ref=dp_byline_cont_book_1 Jim's contact info: https://www.patreon.com/jimrugg https://www.jimrugg.com/shop https://www.instagram.com/jimruggart https://www.twitter.com/jimruggart https://www.amazon.com/Jim-Rugg/e/B0034Q8PH2/ref=sr_tc_2_0?qid=1543440388&sr=1-2-ent
Take time to listen to Omar Khan as he highlights the Theta Strategy and why creative investing is the best vehicle to reach your financial goals. If you want to know the triangle of wealth, lucrative strategies, and how real estate and stocks can work hand-in-hand for you, dive into this episode and invest creatively! Key takeaways to listen for Major differences between the 2008 and 2022 market downturns An excellent overview of inflation and its negative effects How important it is to start using creative investing strategies The power of learning what covered calls are What's happening with the Canadian real estate market? Resources mentioned in this episode Federal Reserve System's Dot Plot About Omar Khan Omar Khan's career spans more than 20 years in financial services. Starting out in the brokerage arm of a Big Five Canadian bank, he quickly rose through the ranks of the industry to RVP in a widely known mutual fund company. He then shifted his focus, becoming a full-time real estate investor and a derivatives trader. Omar holds a BA in Economics from the University of Toronto. He currently spends his professional life trading derivatives, building his real estate portfolio, and promoting the core values of Theta Trading. Connect with Omar Website: Theta Trading Facebook: Theta Trading Instagram: @thetatrading YouTube: Theta Trading Email: email@example.com Connect with Us To learn more about partnering with us, visit our website at https://javierhinojo.com/ and www.allstatescapitalgroup.com, or send an email to firstname.lastname@example.org. Sign up to get our Free Apartment Due Diligence Checklist Template and Multifamily Calculator by visiting https://javierhinojo.com/free-tools/. To join Javier's Mastermind, go to https://javierhinojo.com/mastermind/ and to apply to his BDB Mastermind, see https://javierhinojo.com/mastermind/#apply_form and answer the form. Follow Me on Social Media Facebook: Javier A Hinojo Jr. Facebook Group: Billion Dollar Multifamily and Commercial Real Estate YouTube Channel: Javier Hinojo Instagram: @javierhinojojr TikTok: @javierhinojojr Twitter: @JavierHinojoJr
In this week's episode, we will review a study that cell-free hemoglobin S was found to induce high levels of pro-inflammatory cytokine production in monocytes. The effect is mediated by Toll-like receptor 4, or TLR4, suggesting intriguing therapeutic possibilities for sickle cell disease. Secondly, germinal center B cells with aberrant expression profiles undergo independent clonal evolution in the microenvironment of angioimmunoblastic T-cell lymphoma. New findings published in Blood elucidate mechanisms of disease pathogenesis and uncover a new potential target for treatment. Finally, an upfront combination of three immunosuppressive agents was highly effective and well tolerated in patients with acquired hemophilia A. Although prospective studies are needed, the triple regimen could be an attractive treatment option, particularly for elderly and frail patients.
So glad to be back hosting my podcast after an unexpected multiple month break!! For this first episode of season 4, I'm discussing the lengthy battle many of us face when trying to find a medication that is helpful to our kids, but also one that won't add additional challenges to their day to day behaviors, sleep schedule or appetite. We've been experiencing what I call the "many seasons of Skyler" with regard to his behaviors over the last several months and it's been down right exhausting and frustrating - for him and for our family. I know I'm not alone and would love to hear about the journey each of you listening has been through when it comes to medications for autism/anxiety/moods/ADHD! ***************************************** To purchase my book “Welcome to My Life – A Personal Parenting Journey Through Autism” click HERE or visit Amazon.com! You can easily stay connected to the Living the Sky Life podcast and me in various ways. Please visit my website www.lauriehellmann.com for all the links. I'd love to hear what you think, so if listening on the Apple platform, please leave a written review and rating of the podcast! If you are interested in being a guest on an episode of Living the Sky Life, please contact me!
In this episode of Getting to Aha!, Darshan Mehta is joined by Mike Montague, Director of Community Engagement at Sandler, Speaker, Podcaster, and Game Show Host at Playful Humans. They discuss Mike's aha! journey, his career, and the experiences that made him realize the power of play as a winning mindset. They further talk about the different types of playful personalities and the importance of playfulness as an efficient way to attain productivity across any area.
Paul Hawksbee and Charlie Baker are joined in the studio by comedian and shin model Lloyd Griffith. The guys also spoke to Andrew Maxfield, the grandfather of the youngest ever Blackburn Rovers season ticket holder and talkSPORT's biggest foodie Rupert Bell. Hosted on Acast. See acast.com/privacy for more information.
Today's interview is with Prashanth “PVK” Krishnaswami is the head of market strategy and thought leadership for the CX product group at Zoho. Prashanth joins me today to talk about Zoho's vision for CX, transnational localism, the link between customer success, employee happiness and business results, a new whitepaper and what service and experience leaders should be thinking about and doing. This interview follows on from my recent interview – Product Led Growth (PLG) is missing a pillar – Interview with Joe Andrews and Martin Schneider of SupportLogic – and is number 444 in the series of interviews with authors and business leaders that are doing great things, providing valuable insights, helping businesses innovate and delivering great service and experience to both their customers and their employees. NOTE: A big thank you goes out to the folks at Zoho for sponsoring my podcast this month and particularly the team at Zoho Desk. Zoho Desk is trusted by over 50,000 businesses around the world to elevate their customer service and the team over there recently asked me to write a whitepaper for them that explores How focusing on employee happiness and customer success can drive business results. The whitepaper is called: The Killer Combination: Customer success, happiness and the right technology. Do check it out by following this link.
“Can't” was the word that rang in Minesh's head for 2 years before he decided to join RNT. As an active father with a demanding job, he felt he had no room for anything else in life. But then after a day of excess, he found his foot swollen with gout. It was the last straw. As a man in his mid 30s, he felt his body was deteriorating. And he knew he needed to make a change, so joined RNT. Fast forward a year, Minesh's life has completely transformed. He's lost 30kg, but this goes beyond the physical, and in this episode, we're going to dive into how he achieved such a remarkable change. Time Stamps 00:10 - Combination of factors to wanting to make a change 02:20 - Trigger moment 03:30 - Took 6 months to get the ball rolling 05:55 - Transforming is like learning to drive a car 08:34 - Minesh's ‘Why' 09:30 - RNT opens up avenues in different realms 12:11 - I'm always asking new questions 13:44 - You have to make the time 16:44 - Adapting to the nutrition strategy 19:58 - Following the programme while travelling 22:01 - Minesh had never weight trained before 24:04 - Now addicted to training 25 :40 - The Grind 29:17 - Strength gains after hitting Checkpoint 30:31 - Mindset shift to stay on the path after Checkpoint 33:07 - Hope to inspire friends and family 35:06 - Hitting PRs regularly in the gym 36:56 - How has the physical been the vehicle 38:42 - Advice to new RNTers 41:22 - How to deal with positive and negative reactions from people Book A Call To Start Your Journey! Thanks so much for listening! If you like this episode, please subscribe to “RNT Fitness Radio” and rate and review wherever you get your podcasts: Apple Podcasts Stitcher iHeart Radio Spotify For any podcast suggestions, or if you'd like to get in touch, please do so on email@example.com here. We'd love to hear from you! I'm very excited and proud to announce we've developed a brand new partnership with one of the world's leading premium supplement brands, Optimum Nutrition, where they'll be helping support our RNT members, and listeners of this podcast, on their journey of health, fitness and total transformation. With the world's #1 best-selling protein powder in their range, and a growing plant-based range, you can now use the code RNT20 to get 20% off in their US and UK stores. My personal favourite are their plant-based protein bars. I've literally done a 180 on protein bars since discovering these, and these were a game changer during my recent long stints in Bali and the US! Resources: Take the Transformation Quiz Our Book: Transform Your Body, Transform Your Life Follow RNT Fitness: Website Facebook Instagram YouTube Email Follow Akash: Facebook Instagram LinkedIn
Part four of "The Secret Sauce" series. Pastor Tristan Kennedy gives his winning combination of 3 ingredients for his SECRET SAUCE. He shows us the importance of HAVING VISION, BEING TEACHABLE and a STEADY DIET of THE WORD OF GOD. These three things will help you be successful in your calling...your purpose in God.
How big can onshore wind turbines get? If it seems like we ask this question every month, get used to it: Nordex says there's no limit. That leaves engineers asking, how do you transport a rotor with a 175m diameter? And will the sites themselves become factories? Speaking of manufacturing, Allen and Joel discuss what's behind Siemens and Airborne's efforts in composites processing and automation. Hint: it may be safety as much as cost. In Oregon, operations are underway on the Wheatridge Renewable Energy Facility, a utility-scale development combining wind and solar generation with battery storage. While it's a first in the US, other countries have relied on combined power plants for decades. Worldwide, changes in the energy marketplace - like the UK's plan to cap power producer revenue - give new meaning to the term power diplomacy. Visit Pardalote Consulting at https://www.pardaloteconsulting.com Wind Power Lab - https://windpowerlab.com Weather Guard Lightning Tech - www.weatherguardwind.com Sign up now for Uptime Tech News, our weekly email update on all things wind technology. This episode is sponsored by Weather Guard Lightning Tech. Learn more about Weather Guard's StrikeTape Wind Turbine LPS retrofit. Follow the show on Facebook, YouTube, Twitter, Linkedin and visit Weather Guard on the web. And subscribe to Rosemary Barnes' YouTube channel here. Have a question we can answer on the show? Email us! Uptime 135 Allen Hall: Hello everyone. We have a great show for you this week. Rosemary is still on leave, but we're going to talk about Oregon's new battery, solar and wind utility scale site. The first one in America and the UK is talking about capping renewable power revenues to keep energy prices down. Joel Saxum: And we're gonna jump over to the Nordic countries talk about some wooden wind turbine towers. Joel Saxum: We've talked about these in the past, but now we wanna share with you that they're moving forward. They've got a. Letter of intent from res. So that's, that's cool for them. Also going into 10 megawatt plus onshore wind turbines, do you think it can happen? Do we think it can happen? The CEO of Nordex believes that that is the future. Joel Saxum: And lastly on the show we're gonna talk about Siemens Gamesa partnering with Airborne on some offshore wind turbine blades and looking at automation. So they. Hopefully get the cost of the blades down and the quality up. Allen Hall: I'm Alan Hall, I'm president of Weather Guard, Lightning Tech, and I'm here with my good friend from Wind Power Lab, Joel Saxum, and this is the Uptime Wind Energy Podcast. Allen Hall: All right, Joel. There's a new renewable energy plant up in Oregon about 200 miles directly east of Portland. If you know your geography on the northwest coast of America, it's the Wheatridge Renewable Energy Facility. It's the first utility scale development in North America that combines winds, solar and battery storage. Allen Hall: And it's hard to believe that that's the first one, but it's the first one. Yeah. And the, the plant. Combination effort between NextEra Energy Resources. NextEra is a big wind provider across the country and Portland, Portland General Electric, which has had some problems with wind TURs in the recent past. Allen Hall: So I'm glad they're hooked up with NextEra. on this project. They have 300 megawatts of wind with generated by 120 GE turbines. They have 50 megawatts of, of solar panels. And 30 megawatts of battery storage and they estimate they can provide power to 100,000 homes. Is this the future for America, Joel Saxum: man? Joel Saxum: I think so. If I step into some developer shoes, I'm thinking less permit costs less headache. Yeah. You know, developing on one side, if you get permission from this hunk of land, and we can put all these things here. It also in my mind, and, and I haven't seen their, the business model of course, but in my mind,
Paul Hawksbee and Charlie Baker are joined in the pod by writer and journalist Kieran Morris to talk about creating the ‘Honduran Maradona' and how he subsequently tried to track him down. Plus, comedian and Leeds fan Rob Auton took on the Celebrity Combination Lock and does very very well! Hosted on Acast. See acast.com/privacy for more information.
Robotics, cameras, and rehab. A perfect combination. Orthopedic surgeon, Dr. Grant Garcia discusses a new technology that will revolutionize how patients can rehab and how surgeons can teach. We start out discussing the Avail system. A camera system that utilizes technology, networking, and software to combine the perfect partnership. This Avail system will allow doctors to learn and teach in a way they haven't done before. One technology that has the industry buzzing is coming from the company Hrobotics. They have come out with an FDA-registered robotic, physical therapy device for both the upper and lower extremities called Rebless. Rebles allows for passive, active, active-assisted, and resisted training and range of motion measurement, so therapy can be customized based on each patient's condition and progress. To simplify, as a patient you can take this machine home, and your doctor can program, monitor, and adjust your rehab in real-time. This device can do much more and Dr. Garcia explains all of it. Take a listen, get informed, and enjoy. --- Support this podcast: https://anchor.fm/nyseasportstalk/support
Life With The Girlfriends with Christine Marie and Julie Peters Topic: Broads, Poop, and Asteroids.....not a bad show combination.
Join Professors Iain McInnes and Hideto Kameda as they discuss the latest top research in axSpA. In this edition, our Steering Committee members discuss two of the latest papers in the feild of axSpA theraputics, providing their own insights and experience into two very interesting publications. The first of our publications reports the efficacy and safety results for patients treated with ixekizumab for up to 116 weeks. The second of today's papers evaluated the effectiveness and safety profile of COMBIO, or Combination of Targeted Therapies, in clinical settings. Everything discussed is available in a more detailed slide format in the publications section at cytokinesignalling.com.
Paul Hawksbee and Charlie Baker are joined in the pod by comedian Al Murray who has a new book out. Al also takes on the Celebrity Combination Lock. And Geoff Norcott is on the show promoting his charity comedic gig. Paul and Charlie also talk anxiety dreams with help from you, the listeners! Hosted on Acast. See acast.com/privacy for more information.
In Season 3, Episode 6, Roger Green assembles audio clips from Surfing the NASH Tsunami's coverage of NASH-TAG 2022 to reveal an evolving view of the role combination therapies will play in the treatment and management of NASH patients. Discussion about “combination therapies” typically focuses on the idea of multiple agents prescribed concurrently to address a medical condition when monotherapy will not achieve desired goals. At NASH-TAG 2022, the concept of combination therapies took some interesting directions:Longitudinal drug combinations — initial intervention designed to cause a fast reversal of fibrosis or defatting of the liver, followed by a longer-term therapy (mono or combination, but not with the first-round agent) designed to provide longer-term, more complete metabolic benefits in a regimen that is safer, more tolerable, less expensive, or some combination of these.Longitudinal diagnostics — an early, inexpensive “rule out” test like FIB-4, followed by a liquid or machine-based test that provides more accurate disease staging.Logical combinations — so far, most drug combination trials have resulted from a manufacturer trying to resuscitate a developmental agent that missed endpoints in monotherapy trials. It would be more logical to design combinations based on complementary modes of action.This episode explores these and other combination therapy issues using quotes from the NASH-TAG 2022 coverage and Roger's commentary.
Struggling with chronic pain, health issues or fatigue? Greg “the hydrogen man” was bedridden with pain and chronic fatigue. Sick of multiple medications and no solutions for his health Greg went on a mission to find something that would help him. After rigorous trial and error with a lot of research Greg found that hydrogen water and later hydrogen air combined in the Holy Hydrogen machine helped him to regain his energy and health. In this episode of The Health Fix Podcast, Dr. Jannine Krause interviews Greg on the myths surrounding hydrogen products as well as the benefits of hydrogen gas and water for overall health. What You'll Learn in This Episode: Why how you make hydrogen matters for your safety The difference between Brown's Gas & Hydrogen Gas machines Why using alkaline water can cause gut issues long term Greg's protocol combining hydrogen gas & water with the Holy Hydrogen Machine to increase energy and restore health Japanese studies on the healing properties of hydrogen gas & water How hydrogen capsules can affect your liver and brain negatively Resources From the Show: Holy Hydrogen - use the code "DOCTORJ" for $100 off your purchase of a Lourdes Hydrofix Carbon Water Distillation - MYPUREWATER.COM - Kills viruses and bacteria in water (add Concentrace Minerals to water) Greg's Youtube Channel - UPRISING144K Greg's code for purchasing the Hydrogen Generator system = uprising144K Want to learn more - check out this video on the Science Behind The Health Benefits of Hydrogen Enjoy The Show? Never Miss An Episode Subscribe, Rate and Review the show in iTunes Subscribe via Stitcher or RSS feed Send us feedback via Email Leave a comment below
Over the last few episodes, Darren has been discussing finding solutions using First-Principles. In this episode, Darren debunks another myth many believe, that creativity is something you are born with, and you either have it or don't. Skip the line and secure your seat for the upcoming Business Master Class at BMCInvite.com. Get more personal mentoring from Darren each day. Go to DarrenDaily at http://darrendaily.com/join to learn more.
Why Instagram, and why now? Expert author Jenn Herman busts Instagram myths, shares words of wisdom, and dives into how B2B marketers can get started and use the social media platform to its full potential.
Paul Hawksbee and Charlie Baker are joined in the pod by Japanese football commentator and Taunton Town fan Ben Mabley for West Country Corner. Plus, we talk Apple Throwing Championships with organiser Stuart Gill. And Leeds supporting comedian Jon Richardson takes on Celebrity Combination Lock. Hosted on Acast. See acast.com/privacy for more information.
After a month of major Fatty Liver medical meetings, Jörn Schattenberg, Louise Campbell and Roger Green explore emerging stories that will shape the next 6-12 months in Fatty Liver disease. In this final conversation, the group discusses the importance of combination NIT biomarkers in developing a viable system for treating patients. The key is that NITs provide a viable strategy for widespread patient screening and staging, whereas biopsy does not.Roger also asks about several other issues that will come to the fore in the next year. The first item is the Nomenclature conference. Jörn describes it as a moving target with a clear split between the hemispheres. Asia is moving toward a concept more like metabolic-associated disease, however, Europe and North America are not. He notes that an ongoing process of consensus leaves him hopeful. Roger suggests that redefining the disease itself might lead regulators to disregard the vast amounts of research accomplished. Unfortunately, this has the potential to set the field back several years. Jörn agrees that it is imperative that any solutions do not push back drug or diagnostic approvals. The existing data and procedures around patient enrolment in trials remain clear.The final question returns to the issue of what changes might take place over the next year. Each answer differs and continues themes found in the earlier conversations. Surf on for the group's predictions.
This podcast episode is brought to you by MEFA. Learn more how you can use the money to pay for qualified expenses at Fidelity.com/uFund Emily is joined by NAPS parent, Alesandra, to recount her experience with seeking lactation support. Alesandra and Emily emphasize that there does not need to be an apparent “problem” to utilize lactation professionals. Discussed in this episode: -Open and honest conversation with healthcare providers -Patient advocacy -Breastfeeding & bottle feeding -Combination feeding -Low milk supply -Feeding options -Evidence based care -Hospital birth -Postpartum recovery -Conflicting information -Preventative care -Lactation support & reassurance -CLC/ IBCLC Lactation intake form: We provide both in person (MA) and virtual support (nationally). https://www.nurturebynaps.com/lactation-consult Be sure to follow us on IG @nurturebynaps
"The yield curve is very inverted, while the ISM has stabilized a bit over the past few months. Housing prices are plummeting and sentiment indicators are weak. Also, employment numbers are showing cracks. The stock market today is seeing volatility and on the edge of every Federal Reserve announcement. We will have six to 12 months of rough going. Bonds and stocks are no longer diversifying assets as commodities are a better place to be," says Derek Izuel.
Paul Hawksbee and Charlie Baker are joined in the pod by sheep shearing record holder Marie Prebble. Plus, dual-code Rugby legend Martin Offiah took on the Celebrity Combination Lock. Hosted on Acast. See acast.com/privacy for more information.
This episode deals with viewing life. Like a safe with a combination lock. Put in the right combination and the lock will open for you. --- Support this podcast: https://anchor.fm/christopher-nolan36/support
即刻加入15Mins通勤學英語直播室，每週一9pm等你來說英文 : https://15minsengcafe.pse.is/46hm8k 每日英語跟讀 Ep.K440: How to Get Heart Patients to Take Their Pills? Give Them Just One. Heart disease kills more people than any other condition, but despite advances in treatment and prevention, patients often do not stick to their medication regimens. Now researchers may have found a solution: a so-called polypill that combines three drugs needed to prevent cardiovascular trouble. 死於心臟病的人比死於其他任何疾病的人都多，儘管在治療和預防上取得進展，患者往往不能堅守他們的藥物治療方式。現在，研究人員可能已經找到一個解決方法：一種混合三種預防心血管疾病所需藥物的所謂複方製劑。 In what is apparently the largest and longest randomized controlled trial of this approach, patients who were prescribed a polypill within six months of a heart attack were more likely to keep taking their drugs and had significantly fewer cardiovascular events, compared with those receiving the usual assortment of pills. 在明顯是這種方法規模最大、時間最長的隨機對照試驗中，心臟病發作後6個月內服用複方製劑的患者，跟服用常規藥物患者相比，更有可能繼續服用藥物，心血管事件明顯減少。 The participants also experienced one-third fewer cardiovascular deaths, although their overall risk of death from all causes was not significantly changed. 參與者因心血管疾病死亡人數也減少三分之一，即便他們因為各種原因死亡的總體風險沒有顯著改變。 The study of more than 2,000 heart patients, who were followed for three years, was published Friday morning in The New England Journal of Medicine, as the findings were presented at the European Society of Cardiology Congress in Barcelona, Spain. 這項研究對2000多名心臟病患者進行三年追蹤調查，研究結果周五上午發表在《新英格蘭醫學雜誌》，並在西班牙巴塞隆納舉行的歐洲心臟病學會年會上發表。 The study is the culmination of 15 years of work by researchers led by Dr. Valentin Fuster, director of Mount Sinai Heart at Mount Sinai Hospital in New York City and general director of the National Center for Cardiovascular Research in Spain. 這研究是紐約市西奈山醫院西奈山心臟中心主任、西班牙國立心血管研究中心總監瓦倫丁．福斯特博士帶領研究人員研究15年的結晶。 “Combination pills are easier for the physician and for the patient, and the data are pretty clear — it translates into a benefit,” said Dr. Thomas J. Wang, chair of the department of internal medicine at UT Southwestern Medical Center, who was not involved in the research but wrote an editorial accompanying the study. 未參與研究但為研究報告撰寫社評的德州大學西南醫學中心內科系主任湯瑪斯．王博士說：「複方藥物對醫生和病患來說更簡便，數據非常清楚，它轉化為一種好處。」 The polypill combines a blood-pressure medication, a cholesterol-lowering drug and aspirin, which helps prevent blood clots. 這種複方製劑結合了降壓藥、降膽固醇藥和阿斯匹林，有助防止血栓。 The polypill used in the study has not been approved by the Food and Drug Administration and is not available to patients in the United States right now. Fuster said the results of the new trial would be submitted to the agency shortly in an effort to obtain approval. 這項研究使用的複方製劑還未獲得美國食品藥物管理局批准，目前在美國還不能給患者使用。福斯特 說，這項新試驗結果很快會提交給該機構，以爭取獲得批准。 And since participants became even more likely to keep taking the polypill over time, he said, “The potential results could be even better with more follow-up.” Several studies have shown that only about half of patients, or even less, take all their medications as instructed. 他說，由於參與者會逐漸的更可能繼續服用複方製劑，「若有更多後續研究，潛在結果可能更好」。數項研究顯示，只有大約一半甚至更少患者按照指示服用所有藥物。 The new study, a randomized controlled clinical trial, enrolled just under 2,500 patients at 113 sites in Spain, Italy, France, Germany, Poland, the Czech Republic and Hungary. 這項研究是一項隨機對照臨床試驗，在西班牙、義大利、法國、德國、波蘭、捷克和匈牙利的113個地點招募到近2500名患者。Source article: https://udn.com/news/story/6904/6601708 歡迎留言告訴我們你對這一集的想法： https://open.firstory.me/user/cl81kivnk00dn01wffhwxdg2s/comments Powered by Firstory Hosting
Welcome to Episode 118 of Autism Parenting Secrets. The topic this week is on genes and how better understanding your genetic makeup can lead to better focus and decision making. Bob Miller is our guest and he's back with some exciting new insights. This discussion will build on our first discussion - see Episode 109.So please watch that episode first in order to get the most out of this one.Bob Miller is a Traditional Naturopath specializing in the field of genetic-specific nutrition. In 1993, he opened the Tree of Life practice and he has served as a traditional naturopath for 27 years. He created an online certification course on genetic nutrition that has empowered over 900 health professionals and he founded Functional Genomic Analysis, an online software program that organizes and analyzes genetic SNPS for functional health professionals across the world.This is going to be more of a presentation than a discussion because of the nature of the material. While genes are important, there's something even more impactful. The secret this week is…GENETICS Loads The Gun, ENVIRONMENT Pulls the TriggerYou'll Discover:A Potential Root Cause You Can't Overlook (3:28)The Combination of Factors That Makes People Very Sick (7:31)Why Some People Have Symptoms From Toxic Exposure And Others Don't (10:45)What is the NADPH Steal (13:33)Why Heme Oxygenase and Bilirubin Are Worth Looking At (18:34)What Might Be Behind “Hangry” (24:02)How Software Makes Connections We Couldn't Make Before (38:01)When Ice Cream Helps (44:12)A Misconception That Is Absolutely False (49:25)About Our Guest:For the past several years, Bob Miller has been engaged exclusively with functional nutritional genetic variants and related research, specializing in nutritional support for those with chronic Lyme disease.Bob lectures nationally and internationally at seminars to educate health care practitioners about genetic variants and nutritional supplementation for achieving optimal health, and holds live webinars every other Thursday evening for health professionals. In 2016, he created an online certification course on genetic nutrition for health professionals now training over 900 health professionals in the program.Bob is a frequent guest on many podcasts such as Dr. Jill Carnahan, Better Health Guy, Dr. Joseph Mercola, and many others.To support his growing genetic research efforts, in 2015, Bob founded and personally funds, the NutriGenetic Research Institute to research the relationship between genetic variants and presenting symptoms.His first research project on genetic variants in those with chronic Lyme disease, was one of two winners for research by the ILADS international meeting held in Helsinki, Finland. His Phase II study of Lyme disease was presented at the American ILADS conference in November 2016, Phase III was presented at the International ILADS conference in Paris, France in May 2017 and his Phase IV study on mTOR and Autophagy in Lyme disease was presented in Boston, November 2017. Phase V was presented in Warsaw, Poland in June 2018 and his Phase VI was another winner presented in Chicago, Illinois in November of 2018 which showed increased variants in the Heme pathway and Mast Cell genes. Phase VII presented in Madrid, Spain in June of 2019 research showed how genetic variants in genes related to the production of and utilization of NAD+ and NADPH are creating what is now referred to as the ‘NADPH Steal'. In 2020, he presented his research at the online ILADS conference on genetic mutations in the synthesis and utilization of bile.Bob has created 72 nutritional supplement products exclusively for health professionals for Professional Health Products and Functional Genomic Nutrition through Compounded Nutrients. The products he formulated are based upon his genetic research and are designed to support function that may be impaired by genetic weakness.Bob is the founder and president of Functional Genomic Analysis, an online software program that organizes and analyzes genetic SNPS for functional health professionals across the world.Memberships:National Association of Certified Natural Health ProfessionalsAmerican Association of Nutritional ConsultantsBoard Certified Naturopath - American Naturopathic Certification & Accreditation BoardBob MillerTree of Life References In This Episode:Watch the VIDEO version of this discussion hereAccess the complete presentation PDF hereAutism Parenting Secrets Episode 109, Genes are CLUES, Not Destiny Additional Resources:Take The Quiz: What's YOUR Top Autism Parenting Blindspot?Free Resource: 33 Mistakes Most Autism Parents Make and How To Avoid ThemGot a Picky Eater? - this can helpTo learn more about Cass & Len, visit us at www.autismparentingsecrets.comBe sure to follow Cass & Len on Instagram If you enjoyed this episode, share it with your friends.Don't forget to subscribe to the show on Apple Podcasts to get automatic episode updates for our "Autism Parenting Secrets!"And, finally, please take a minute to leave us an honest review and rating on Apple Podcasts. They really help us out when it comes to the ranking of the show and we read every single one of the reviews we get. Thanks for listening!
A new/old TikTok trend suggests cooking chicken with NyQuil. Mike, Nate, and Jack discuss this, along with more pleasant-tasting medicines in general. Jack is also reminded of his disdain for 3 Doors Down and Nickelback.
#3203, Sep. 21, 2022: A father and son combination established the stylized tradition (this title is from " A guidebook to Japan and its Cuspoms") Today's pure primal piano music here. Happy if this music makes you feel peaceful.. : ) Looking for absolute natural beauty every day for Piano Ten Thousand Leaves. Target number is 4536 and 3203(70.6%) achieved today. Find my project.. : ) This piece may might have good 1/f fluctuation characteristic although I stopped investigating it each piece. ######## NEW 22nd SELECTION ALBUM JUST RELEASED ######## "Midsummer Light" - the 22nd selection album of piano ten thousand leaves Youtube: Full(20 songs, 50 minutes) and Free 4K Video with Super Beautiful Motion Graphics of Artgrid https://youtu.be/NrGOHU8Oq8I spotify https://open.spotify.com/album/0xbAyejkTEictsVmLxwc0v apple music https://music.apple.com/jp/album/1639517632 amazon music https://www.amazon.co.jp/s?k=chair+house+%E7%9C%9F%E5%A4%8F%E3%81%AE%E3%81%B2%E3%81%8B%E3%82%8A+-+%E3%83%94%E3%82%A2%E3%83%8E%E4%B8%87%E8%91%89%E9%9B%86+-+%E7%AC%AC22%E9%81%B8&i=digital-music&ref=nb_sb_noss_2 Line Music https://music.line.me/webapp/album/mb00000000028c4baf AWA https://s.awa.fm/album/d9a568a7ba17bc6aa983 Other Every music streaming services in the world https://linkco.re/HR7gvxuN
a father and son combination established the stylized tradition - #3203 by chair house 09212022.mp3a father and son combination established the stylized traditionいつだって穏やかで優しく美しいフランです。ではでは．．☆☆☆☆☆■ＰＳ１：弥生三月君を愛した30年 という映画。前にも見たけどまた観た。あんまりおもしろいわ..
BUFFALO, NY- September 20, 2022 – A new research paper was published in Oncotarget's Volume 13 on September 14, 2022, entitled, “Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy.” Loss-of-function mutations in genes encoding the Krebs cycle enzymes Fumarate Hydratase (FH) and Succinate Dehydrogenase (SDH) induce accumulation of fumarate and succinate, respectively, and predispose patients to hereditary cancer syndromes including the development of aggressive renal cell carcinoma (RCC). Fumarate and succinate competitively inhibit αKG-dependent dioxygenases, including Lysine-specific demethylase 4A/B (KDM4A/B), leading to suppression of the homologous recombination (HR) DNA repair pathway. Researchers Daiki Ueno, Juan C. Vasquez, Amrita Sule, Jiayu Liang, Jinny van Doorn, Ranjini Sundaram, Sam Friedman, Randy Caliliw, Shinji Ohtake, Xun Bao, Jing Li, Huihui Ye, Karla Boyd, Rong Rong Huang, Jack Dodson, Paul Boutros, Ranjit S. Bindra, and Brian Shuch from Yale University School of Medicine, West China Hospital/School of Medicine, Wayne State University, and University of California, Los Angeles have developed new syngeneic Fh1- and Sdhb-deficient murine models of RCC, which demonstrate the expected accumulation of fumarate and succinate, alterations in the transcriptomic and methylation profile, and an increase in unresolved DNA double-strand breaks (DSBs). “In this study, we sought to examine the activity of combined TMZ and PARPi in Krebs-cycle-deficient renal cancer models. Fh1 and Sdhb are the murine counter part of human FH and SDHB, respectively.” The efficacy of poly ADP-ribose polymerase inhibitors (PARPis) and temozolomide (TMZ), alone and in combination, was evaluated both in vitro and in vivo. Combination treatment with PARPi and TMZ results in marked in vitro cytotoxicity in Fh1- and Sdhb-deficient cells. In vivo, treatment with standard dosing of the PARP inhibitor BGB-290 and low-dose TMZ significantly inhibits tumor growth without a significant increase in toxicity. These findings provide the basis for a novel therapeutic strategy exploiting HR deficiency in FH and SDH-deficient RCC with combined PARP inhibition and low-dose alkylating chemotherapy. “Using newly developed Fh1 and Sdhb deficient syngeneic mouse models, we demonstrate that oncometabolite-induced HR defects can be leveraged with PARPi treatment to enhance sensitivity to low-dose TMZ in Krebs-cycle-deficient renal cancer.” DOI: https://doi.org/10.18632/oncotarget.28273 Correspondence to: Ranjit S. Bindra & Brian Shuch – Emails: Ranjit.Bindra@yale.edu & firstname.lastname@example.org Keywords: FH, SDHB, renal cell carcinoma, PARP inhibitor, temozolomide About Oncotarget: Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. To learn more about Oncotarget, visit Oncotarget.com and connect with us on social media: Twitter – https://twitter.com/Oncotarget Facebook – https://www.facebook.com/Oncotarget YouTube – www.youtube.com/c/OncotargetYouTube Instagram – https://www.instagram.com/oncotargetjrnl/ LinkedIn – https://www.linkedin.com/company/oncotarget/ Pinterest – https://www.pinterest.com/oncotarget/ LabTube – https://www.labtube.tv/channel/MTY5OA SoundCloud – https://soundcloud.com/oncotarget For media inquiries, please contact: email@example.com.
This week listen as Jen sits down with guest Tim Herriage, Executive Director at RCN Capital. Tim shares with us his tips on developing high cash flow using combination strategies between traditional rentals and other income streams in the housing market. BIO: Tim Herriage is the Executive Director at RCN Capital and host of The Uncontested Investing Show. Tim is a professional real estate investor and entrepreneur. For two decades Tim has been on the leading edge of the Real Estate Investor (REI) space. This includes being the Founder of 2020 REI Group, Co-Founder and Managing Director of Blackstone's B2R Finance, Founder of the REI Expo, as well as a Franchisee and Development Agent for HomeVestors® of America. Tim has completed well over $1 Billion in real estate investment transactions, including the acquisition of more than 2,000 houses in his twenty-one-year career. Tim currently purchases and repositions approximately 50 homes per year in the Dallas market through his various real estate companies while serving as Executive Director for RCN Capital. Tim built and sold six companies by the age of 40 and enjoys empowering entrepreneurs and investors by sharing raw truths about the mistakes he has made. Connect with Tim: Website: https://rcncapital.com/ Social Media Handle: @timherriage on all platforms Learn more about your ad choices. Visit megaphone.fm/adchoices
Download Transcript If you've undergone a septoplasty and your nose is still stuffy, this video is for you. I'll reveal what steps you and your surgeon can take to fix your breathing problem once and for all. ✅ For your complete guide on how to clear your stuffy nose for good, read my e-book on How to Unstuff Your Stuffy Nose: Breathe Better, Lose weight, Sleep Great. https://www.unstuffyourstuffynose.com/ ✅ Video Chapters 00:00 Introduction 00:14 Why you have a deviated septum 03:21 The septoplasty procedure 04:08 7 common reasons why your septoplasty didn't work 04:14 1. The septum was not addressed fully 04:32 2. Too conservative turbinate surgery 04:52 3. Not addressing flimsy nostrils 05:04 4. Combination of above 05:39 Two-step maneuver to determine what's causing your stuffy nose after surgery 06:21. 5. Chronic medical conditions and too much estrogen 06:41 6. Acid reflux 07:05 7. Gluten or dairy allergies 07:18 Summary ✅ Links Mentioned in Video 7 Long -Lasting Ways to Clear Your Stuffy Nose - ENT Doctor Approved Sleep, Interrupted: A Physician Reveals The #1 Reason Why So Many Of Us Are Sick And Tired ✅ Dr. Park's Products and Services How you can lose weight naturally without cardio or counting calories. Dr. Park's The 90-Day Sleep Diet. Want to un-stuff your stuffy nose? Read the e-book, How to Un-stuff Your Stuffy Nose: Breathe Better, Lose Weight, Sleep Great (PDF) Your Health Transformation Workbook: Refresh, Restore, & Rejuvenate Your Life (online format) Want to have more energy, sleep better, have less pain, and enjoy living again? Reserve a Virtual Coaching session today with Dr. Park ✅ Connect with Dr. Park DoctorStevenPark.com firstname.lastname@example.org For inquiries about interviews or presentations, please contact Dr. Park through his website at doctorstevenpark.com. ✅ Disclaimer This video is for general educational and informational purposes only. It is not to be taken as a substitute for professional medical advice, diagnosis, or treatment. Please consult with your doctor first before making any changes to your health, exercise, nutrition, or dietary regimen. Certain product links above will take you to Amazon.com. If you then go on to buy the product, Amazon will provide me with a small commission, which will not cost you anything.
Some claim that a protein in milk inactivates antioxidants in fruit. Are blueberries and yogurt a bad idea?Nutrition Diva is hosted by Monica Reinagel. A transcript is available at Simplecast.Have a nutrition question? Send an email to email@example.com or leave a voicemail at 443-961-6206.Find Nutrition Diva on Facebook and Twitter, or subscribe to the newsletter for more diet and nutrition tips.Nutrition Diva is a part of Quick and Dirty Tips.Links: https://www.quickanddirtytips.com/https://www.quickanddirtytips.com/nutrition-diva-newsletterhttps://www.facebook.com/QDTNutrition/https://twitter.com/NutritionDiva https://nutritionovereasy.com/
Ben Maller and his 5th Hour home-slice Danny G. have a fun Saturday in the podcast dojo for you! They talk Carpool Benny, Opening Day, Cookie Monster, Trash Can Man, back scratcher and more! ...Subscribe, rate & review "The Fifth Hour!" https://podcasts.apple.com/us/podcast/the-fifth-hour-with-ben-maller/id1478163837 Engage with the podcast by emailing us at RealFifthHour@gmail.com ... Follow Ben on Twitter @BenMaller and on Instagram @BenMallerOnFOX ... Danny is on Twitter @DannyGRadio and on Instagram @DannyGRadio ... #BenMallerSee omnystudio.com/listener for privacy information.
We have been celebrating the Warriors all summer and this week is no different. Andre & Evan kick off the show by recapping their recent trip to NBA Summer League in Las Vegas and asking, "Does Summer League even matter anymore?" Later Andre & Evan debate T-Pain's commentary about whether Tupac would be a top emcee in today's music. And for the Guns & Butter segment, Andre explains the recent merging of his favorite worlds as an increasing number or sports leagues begin to allow venture capital firms to finally invest in their teams. Lastly, Warriors owner Joe Lacob joins the show to talk about building a dynasty, how he accumulated wealth in business after a long stint in the sciences, his maniacal focus on winning, how to build a thriving team and how he really feels about the lightyear comments. Learn more about your ad choices. Visit megaphone.fm/adchoices