Podcasts about Combination

Come to a Dehoarding Accountability Zoom Session: http://www.overcomecompulsivehoarding.co.uk/ticket Subscribe to the podcast: https://www.overcomecompulsivehoarding.co.uk/subscribe Podcast show notes, links and transcript: http://www.overcomecompulsivehoarding.co.uk/  Why is it so hard to deal with uncertainty, and what does that have to do with hoarding? This week I'm joined by Dr Jan Eppingstall to unpack how our brains handle ambiguity, why fear of making mistakes can keep us stuck, and how intolerance of uncertainty feeds into hoarding behaviours. We break down practical ways to build up your tolerance for not knowing and share some strategies that might actually make a difference. Uncertainty and Its Challenges Definition and context of uncertainty Evolutionary reasons for discomfort with uncertainty (Selfish Brain Theory) Contrast between historical resource scarcity and modern abundance Our minds' outdated ways of managing uncertainty Cognitive Closure What is cognitive closure? Difference between cognitive closure (psychological need for definite answers) and “closure” in pop culture (emotional resolution) How it relates to need for certainty in present/future, not just past events The creation of cognitive closure measurement scales by researchers Factors influencing need for cognitive closure: Personality traits: Conscientiousness, neuroticism (now called emotionality), openness to experience, extroversion Trauma history and its effects on the nervous system Neurodivergence (with emphasis on autism and “sticky thinking”) Combination of personality, trauma, and neurodivergence Intolerance of Uncertainty Psychological definition of intolerance of uncertainty Negative cognitive bias: How it affects perception and response Manifestations in people experiencing uncertainty as distress Its direct relevance to hoarding behaviours The Link Between Hoarding Disorder and Intolerance of Uncertainty Research findings: intolerance of uncertainty as a predictor of hoarding symptom severity Usefulness in early intervention strategies intolerance of uncertainty as a transdiagnostic factor (across anxiety, some depression, and other mental health conditions) How heightened anxiety sensitivity in hoarding perpetuates avoidance Experiential avoidance in hoarding (saving and acquiring behaviours) Connection between maladaptive behaviours and intolerance of uncertainty Fear of Making Mistakes and Perfectionism Common fears of mistakes in hoarding (disposing, acquiring, putting things away) Perfectionism's role (fear of failure, not wasting) All-or-nothing thinking and rigid decision-making rules Paralysing effect of avoidance due to fear of mistakes Not making a decision as a potential mistake itself Interaction and reinforcement between perfectionism and intolerance of uncertainty Comorbidity and Severity Research on multiple diagnoses: More than half of psychiatric patients have more than one diagnosis Diagnostic challenges and overlapping criteria How comorbidity compounds issues: More symptoms and more complexity Higher intolerance of uncertainty linked with more severe hoarding, especially when other conditions are present Impact on treatment difficulty intolerance of uncertainty's Impact on Acquiring and Discarding Behaviours How acquiring reduces fear of missing out and future needs Difficulty discarding as protection against future regret Shame around mistake-making Common inner questions: Future use, responsibility, relationships More complexity leading to more avoidance Nuances in intolerance of uncertainty and Hoarding Study on sub-factors of uncertainty: Factor 1: Negative self-referential implications (linked to hoarding severity) Factor 2: Perception of uncertainty as unfair (not linked) Internal vs. external perspectives on uncertainty Relevance of anxiety-driven self-criticism Changing Relationship to Uncertainty: Curiosity and Reframing Rilke's quote on “loving the questions” Transforming approach from fear to curiosity Curiosity as a therapeutic tool Creativity in imagining alternatives and solutions Relevance of loss aversion and cognitive biases Modern Life and Uncertainty Intolerance Research linking increased use of technology (instant answers) to rising intolerance of uncertainty Smartphone/information overload and decreased tolerance “muscle” Relevance to hoarding (desire for backups, information saving) Example: IMDb, screenshots, saving digital info Treatment Strategies Cognitive Behavioural Therapy (CBT) effects on intolerance of uncertainty in anxiety Acceptance and Commitment Therapy (ACT) and exposure-based methods: Pros and cons Importance of a therapist experienced in error-related distress and uncertainty Key skills: Observing distress, sitting with uncomfortable feelings, gradual exposure Self-help approaches: Reframing mistakes as learning Practicing self-compassion Values-based decision-making Systematic exposure to small errors Gradually breaking rigid rules (e.g., waste, tidiness) Recognising individual differences and seeking appropriate support Embracing Mistakes and Humanity Learning from therapist/client anecdotes Cultural expectations around perfectionism vs. real human messiness How mistakes can be positive or even entertaining Letting go of the need for perfection The Four Cs for Managing Uncertainty From Elizabeth Weingarten: Curiosity, Conversation, Community, Commitment How to foster each: Curiosity: Approach with questions and exploration Conversation: Discuss uncertainties with trusted people Community: Build social support Commitment: Dedication to exploring questions and knowing when to let go Links Hillman, S. R. HOARDING DISORDER AND Intolerance of Uncertainty, Anxiety Sensitivity and Distress Tolerance in Hoarding Disorder Compared to OCD and Healthy Controls - Shemariah R. Hillman; Claire L. Lomax; Nadeen Khaleel; Theresa R. Smith; James D. Gregory Baldwin, P. A Multimethod Examination of Vulnerability in Hoarding, UNSW Sydney, 2016. https://doi.org/10.26190/UNSWORKS/19156 Castriotta, N.; Dozier, M. E.; Taylor, C. T.; Mayes, T.; Ayers, C. R. Intolerance of Uncertainty in Hoarding Disorder. Journal of Obsessive-Compulsive and Related Disorders 2019, 21, 97–101. https://doi.org/10.1016/j.jocrd.2018.11.005 Exploring Humanity's Relationship to Uncertainty with Elizabeth Weingarten  Podcast ep 49: Sitting with discomfort: distress tolerance and hoarding – How unconscious distress avoidance might be worsening your problems Podcast ep 190: What if we forgive ourselves, but now we know better, we do better? Choosing compassion over shame in hoarding disorder Podcast ep 182: What are “towards and away moves” and what on earth do they have to do with hoarding recovery? With Dr Jan Eppingstall Podcast ep 127: Overcoming overspending with Paige Pritchard, Money Coach Come to a Dehoarding Accountability Zoom session: Accountability Booking Form Dr Jan Eppingstall at Stuffology https://www.facebook.com/stuffologyconsulting/ https://twitter.com/stuff_ology https://www.instagram.com/stuff_ology/ Dr Jan Eppingstall on Pinterest Website: Overcome Compulsive Hoarding Become a Dehoarding Darling Submit a topic for the podcast to cover Questions to ask when dehoarding: https://www.overcomecompulsivehoarding.co.uk/podquestions Instagram: @thathoarderpodcast Twitter: @ThatHoarder Mastodon: @ThatHoarder@mastodon.online TikTok: @thathoarderpodcast Facebook: Overcome Compulsive Hoarding with That Hoarder Pinterest: That Hoarder YouTube: Overcome Compulsive Hoarding with That Hoarder Reddit: Overcome Compulsive Hoarding with That Hoarder subreddit Help out: Support this project Sponsor the podcast Subscribe to the podcast Subscribe to the podcast here

The Broncos haven't had a quarterback/head coach combo in consecutive years since 2014, until now. How lethal is the Payton-Nix duo? And is it true that almost all great QB's have great head coaches as well and vice versa? In Year 3 of the Sean Payton era, are the Broncos on schedule? Plus, a look at the early portion of the Broncos 2025 schedule. And if you could choose a 'homegrown duo' from the Broncos, which two players would you go with - active players and an all-time duo? Eric Goodman and Bruce Haertl are back after the weekend on Hot Takes!

In this episode, Joseph W. Franses, MD, PhD; Neehar Parikh, MD, MS; and Mark Yarchoan, MD, share their thoughts on incorporating immune checkpoint inhibitors into the care of patients with HCC including:Clinical Considerations for Selecting First-line Immunotherapy Combinations for Metastatic HCCOverview of the Latest Data for the Combination of TACE With Immunotherapy (eg, EMERALD-1 Study of TACE and Durvalumab ± Bevacizumab for Unresectable HCC; and LEAP-012 Study of TACE + Lenvatinib + Pembrolizumab) Latest Clinical Data and Updates for Systemic Therapy in Patients With High-Risk Early HCCProgram faculty:Joseph W. Franses, MD, PhDAssistant Professor of MedicineSection of Hematology-OncologyUniversity of ChicagoChicago, IllinoisNeehar Parikh, MD, MSAssociate ProfessorLi Ka Shing Research Professor of HepatologyClinical Director of HepatologyMedical Director, Liver Tumor ProgramDivision of Gastroenterology & HepatologyUniversity of MichiganAnn Arbor, MichiganMark Yarchoan, MDAssociate ProfessorSidney Kimmel Comprehensive Cancer CenterJohns HopkinsBaltimore, Maryland Resources:To access the resources associated with this podcast discussion, please visit the program page to access a recording from a live webinar and a frequently-asked questions commentary on this topic.

  At a time in which our nation continues to experience the regular horror of school shootings, it's understandable that everyone grasps for ideas – anything – that seems like it might prevent or reduce the terrifying carnage. The gruesome notion of a disturbed killer gunning down innocent children is enough to make anyone wish […]

Optimiza tu LDL Colesterol e interpreta tu analítica o las de tus pacientes hoy, sin fármacos, aplicando estrategias nutricionales y suplementos clave con dosis y ciencia. Accede aquí:https://philhugo.com/producto/ldl-colesterol/  ¡Te espero dentro!Los suplementos be levels mencionados que formulo personalmente: Tu código de descuento: INTERGALACTICOBerberina: https://shop.belevels.com/products/berberine?sca_ref=745165.uf0cpcacla Omega 3: https://belevels.com/products/omega3?sca_ref=745165.uf0cpcaclaTriple Magnesio: https://belevels.com/products/magnesium?variant=47417739379012.uf0cpcacla Dosis y los demás explicados en el curso de Control Absoluto del LDL Colesterol.¿Sigues una dieta cetogénica estricta y tu LDL se ha disparado a niveles que asustarían a cualquier médico? No estás solo. En este episodio, desentrañamos la fisiología del Lean Mass Hyperresponder (LMHR): un perfil metabólico donde el colesterol LDL se eleva no por enfermedad, sino por eficiencia energética. Aprende cómo tu hígado, en ausencia de glucosa, convierte grasa en combustible a través de VLDL y LDL. Descubre por qué un LDL de 300 mg/dL puede ser normal si tu HDL está alto, tus triglicéridos bajos y tu inflamación es cero. Estudio a estudio, desmonto los miedos injustificados y propone estrategias clínicas reales para modular tu LDL si es necesario, desde el aumento de carbohidratos limpios hasta la optimización tiroidea y muscular. Este episodio no es para quien se conforma con los rangos de laboratorio estándar. Es para quien quiere entender su cuerpo desde la lógica metabólica y tomar decisiones con ciencia, no con miedo.ReferenciasApoB es biomarcador y posible diana terapéutica cardiovascular. Behbodikhah, Jennifer et al. “Apolipoprotein B and Cardiovascular Disease: Biomarker and Potential Therapeutic Target.” Metabolites vol. 11,10 690. 8 Oct. 2021LDL sube mucho en "lean mass hyper-responders" con dieta baja en carbohidratos. Norwitz, Nicholas G et al. “Elevated LDL Cholesterol with a Carbohydrate-Restricted Diet: Evidence for a "Lean Mass Hyper-Responder" Phenotype.” Current developments in nutrition vol. 6,1 nzab144. 30 Nov. 2021Marcadores tiroideos y composición corporal predicen cambios en LDL con dieta cetogénica. Cooper, Isabella D et al. “Thyroid markers and body composition predict LDL-cholesterol change in lean healthy women on a ketogenic diet: experimental support for the lipid energy model.” Frontiers in endocrinology vol. 14 1326768. 21 Dec. 2023Omega-3 mejora dislipidemia en relación dosis-respuesta. Wang, Tianjiao et al. “Association Between Omega-3 Fatty Acid Intake and Dyslipidemia: A Continuous Dose-Response Meta-Analysis of Randomized Controlled Trials.” Journal of the American Heart Association vol. 12,11 (2023): e029512.Omega-3 de prescripción tiene efectos lipídicos beneficiosos. Bays, Harold E et al. “Prescription omega-3 fatty acids and their lipid effects: physiologic mechanisms of action and clinical implications.” Expert review of cardiovascular therapy vol. 6,3 (2008): 391-409La berberina reduce lípidos, sola o combinada. Koppen, Laura M et al. “Efficacy of Berberine Alone and in Combination for the Treatment of Hyperlipidemia: A Systematic Review.” Journal of evidence-based complementary & alternative medicine vol. 22,4 (2017): 956-968.Niacina baja lipoproteína(a) según fenotipo de apo(a). Artemeva, N V et al. “Lowering of lipoprotein(a) level under niacin treatment is dependent on apolipoprotein(a) phenotype.” Atherosclerosis. Supplements vol. 18 (2015): 53-8

Scheim does the news: Sharks and flooding are becoming a problem // Mego talks Celtics' financial strategies, going after Lillard // Diabetes Barbie and automatic bike washing is a thing //

In this week's episode, we'll learn about rapid, high-sensitivity diagnostic assays for TTP, or thrombotic thrombocytopenic purpura, that can reduce unnecessary treatments. After that: enhancing PD-1 blockade in relapsed/refractory extranodal NK/T-cell lymphoma. In a single-arm, phase 2 study, combined CD38 and PD-1 inhibition demonstrated durable responses and manageable safety. Finally, a lymphoma horror story with a happy ending. CREBBP mutations create a zombie enzyme that competes with its wild-type counterparts. By enforcing CD40 signaling, a bispecific antibody overcomes this effect and induces lymphoma cell death.Featured Articles:Rapid ADAMTS13 activity assays for thrombotic thrombocytopenic purpura: a systematic review and meta-analysisEfficacy of combined CD38 and PD-1 inhibition with isatuximab and cemiplimab for relapsed/refractory NK/T-cell lymphomaBlunted CD40-responsive enhancer activation in CREBBP-mutant lymphomas can be restored by enforced CD4 T-cell engagement

Can Rowan Marshall and Tom De Koning work well together, or is getting TDK going to push Ro out the door? Supposedly Geelong, Adelaide and maybe even Carlton could look to prize him out of Moorabbin... for the right price. Hosted on Acast. See acast.com/privacy for more information.

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The combination of robots and Artificial Intelligence is a scary prospect that has some seriously concerned. So how far could we see AI robots develop? Futurist Skeeve Stevens told Dean Miller on 4BC Breakfast, "I use AI a lot and I see a lot of people that think they're completely amazed by it, it knows everything." "No, it doesn't." "If you ask it some actual slightly complicated questions, it does get a bit confused."See omnystudio.com/listener for privacy information.

Bubblegum Noise, also known as the combination of Pink Noise and White Noise, creates a balanced, soothing soundscape. White Noise, with its broad frequency range, effectively masks disruptive sounds, promoting focus or sleep. Pink Noise, with its richer, more natural tones, emphasizes lower frequencies, creating a calming atmosphere. Together, they blend perfectly, offering an ideal environment for relaxation, concentration, or rest. This harmony provides a tranquil backdrop that helps mask distractions, promote mental clarity, and enhance relaxation. ❗ ❗ To support this podcast and unlock all the ad-free and intro-free episodes, along with other benefits, SUBSCRIBE at ⁠⁠https://12hourwhitenoise.supercast.com⁠⁠ ❗ ❗Although there may be an ad or two at the very beginning of this free episode, you can rest assured that there will be no further interruptions or ads once the Sleep Sound begins

Welcome to my podcast, The Wellness Project with Des, where I speak about all things mental health and wellness to bring you actionable tips you can implement in your own life to help improve your mental health and overall well-being.On today's episode, I speak with therapist Caitlan Siegenthaler about how she combines Internal Family Systems and Human Design in her practice. For detailed show notes and where to find Caitlan: accordingtodes.com/199Want to work together? Schedule your free 30-minute consultation call:https://calendly.com/thewellnessprojectwithdes/coaching-consultationShow your love and support for the podcast by buying me a cup of coffee: buymeacoffee.com/thewellnessprojectwithdesShop wellness and positivity products from my Redbubble store:https://www.redbubble.com/people/AccordingtoDes/shop?asc=uCheck out books and products written or recommended by my amazing podcast guests:https://www.amazon.com/shop/influencer-3be311d1?ref_=cm_sw_r_cp_ud_aipsfshop_aipsfinfluencer-3be311d1_GRVS2AR62H5TFFHR13RQBecome a part of my Facebook community: facebook.com/groups/accordingtodesFollow me on Instagram: instagram.com/thewellnessprojectwithdesFollow me on TikTok: tiktok.com/@therapywithdes.lcswI would greatly appreciate it if you would take a moment to leave a review for my podcast on iTunes and/or Spotify. Thank you! https://podcasts.apple.com/us/podcast/the-wellness-project-with-des/id1477570126

BUFFALO, NY – July 1, 2025 – A new #review was #published in Volume 16 of Oncotarget on June 17, 2025, titled “Optimizing enfortumab vedotin plus pembrolizumab therapy.” First authors Elias Antoine Karam of the Gustave Roussy and Saint-Joseph University of Beirut and Yaghi César Céline from the Saint-Joseph University of Beirut, along with their colleagues, reviewed recent developments about treating advanced urothelial carcinoma (aUC), an aggressive form of bladder cancer. Their review highlights how combining enfortumab vedotin and pembrolizumab as a first-line treatment offers a major improvement for patients with limited options and poor prognoses. Advanced urothelial cancer has traditionally been treated with platinum-based chemotherapy, which often causes serious side effects and offers limited long-term benefit. Many patients are even ineligible for it due to underlying health conditions. The new combination presents a more effective and better-tolerated alternative, as shown in recent clinical trials reviewed by the authors. Enfortumab vedotin targets Nectin-4, a protein present in most urothelial cancer cells, delivering a cancer-killing agent directly into tumors. Pembrolizumab helps the immune system detect and destroy cancer cells. Together, they have shown strong results in extending survival with fewer serious side effects than chemotherapy. These findings led to FDA approval in 2023 for use in a broad range of patients, including those unable to tolerate traditional treatments. “In the phase II KEYNOTE-052 study, pembrolizumab demonstrated significant efficacy as initial therapy in patients with aUC who were ineligible for a cisplatin-based regimen.” The review also compares this new approach with other evolving strategies, such as therapies using nivolumab and chemotherapy combinations. Among current first-line options, enfortumab vedotin and pembrolizumab have produced the most promising outcomes. However, the best course of action following disease progression remains unclear. Other important challenges raised in the review include the high cost of the new therapies, limited patient access to them, and the absence of reliable biomarkers to predict individual response. The authors call for further studies to refine treatment strategies and explore blood-based tools that could guide therapy decisions and minimize side effects. This review offers a clear summary of how recent clinical advances are reshaping the treatment of aUC. It reflects a shift away from traditional chemotherapy toward immunotherapy and targeted, personalized treatments that aim to extend survival and improve quality of life. DOI - https://doi.org/10.18632/oncotarget.28741 Correspondence to - Elias Antoine Karam - eliaskaram18@gmail.com Video short - https://www.youtube.com/watch?v=VrTXaF2qW2k Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28741 Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ Keywords - cancer, advanced urothelial carcinoma (aUC), enfortumab vedotin, pembrolizumab, treatment strategies, bladder cancer To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

❗ ❗UPDATE ❗ ❗Per listener request, I've updated the name of this episode

If you could take two pills (once a week) and live 30% longer, would you? Because a study on mice using drugs approved for humans suggests you may have to answer this question soon.

The Bishop Score was originally developed in 1964 by Dr. Edward Bishop and remains the central assessment tool for determining the appropriateness of cervical ripening for labor induction. We have covered pharmacologic and mechanical methods of cervical ripening for labor induction many times in prior episodes. Ut now, in July 2025, there will be a new clinical practice guideline (#9) from the ACOG which has some notable items. Does the ACOG recognize COMBINATION mechanical and pharmacologic agents for cervical ripening for labor induction? What about outpatient cervical ripening? What are the recommended protocols for oral and vaginal prostaglandins? Listen in for details.

This week, Chitra Eder and I discussed how massage is perceived in Ayurveda and TCM, different massage practices, and benefits for women in perimenopause and menopause.If you are interested in learning more about how these traditional forms of medicine can support your menopause journey, then join us live every Thursday for more conversations.Do check out Chitra's upcoming Ayurvedic Solstice Workshop happening this Saturday.Stay tuned for more information on my upcoming Rebalance & Restore: Menopause Support Through the Combination of Traditional Chinese Medicine & Essential Oils This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit clarissakristjansson.substack.com

What are your odd combination sandwiches? full 2295 Fri, 20 Jun 2025 18:49:33 +0000 rtvS6YvPvBHSqdDx1mZJclWqEJqQ3EQg news MIDDAY with JAYME & WIER news What are your odd combination sandwiches? From local news & politics, to what's trending, sports & personal stories...MIDDAY with JAYME & WIER will get you through the middle of your day! © 2025 Audacy, Inc. News False https://player.amperwavepodcasting.com?feed-link=ht

Sign up to Easy Ayurveda Video Classes by clicking the link belowhttps://www.easyayurveda.com/video-classes/Video Course: “Ayurvedic food and Nutrition”https://www.easyayurveda.com/nutrition/Buy Tridosha Made Easy Bookhttps://www.easyayurveda.com/tridosha-made-easy-3/Buy Tridosha Made Easy Book in Spanish LanguageEl corazón de los doshas: Nuevo librohttps://www.easyayurveda.com/el-corazon-de-los-doshas/Click to know more about Easy Ayurveda Hospitalhttps://www.easyayurveda.com/hospital/Buy our new course on Marma Therapy Part 1https://www.easyayurveda.com/marma1Buy our new course on Marma Therapy Part 1Subscribe to Easy Ayurveda Video Classes https://www.easyayurveda.com/video-classes/Subscribe to our free Easy Ayurveda newsletter here (you can unsubscribe and stop them anytime) -  https://forms.aweber.com/form/58/2129766958.htm Buy our course on diabetes reversal, powered by Madhavbaug https://www.easyayurveda.com/diabetes Buy our online video course on Treatment of cardiac disorders with Ayurveda https://www.easyayurveda.com/heartMaster ECG in one week. Sign up for video course https://www.easyayurveda.com/ecgContact Dr. MB Gururaja BAMS MD (Ayu)https://www.easyayurveda.com/gururaja  Contact Dr. Raghuram YS BAMS MD (Ayu)https://www.easyayurveda.com/raghuram Buy Easy Ayurveda Ebooks https://www.easyayurveda.com/my-book Buy Easy Ayurveda Printed Books https://www.easyayurveda.com/books/

In this episode of RCA Radio, host Brandon Miller sits down with Jessica Schafersman, a design and development expert at RCA®, to break down the increasingly complex world of combination products—those that blend drugs, devices, or biologics. Jessica shares insights on why these products are uniquely challenging, the regulatory expectations companies must meet, and how the FDA guidance that is intended to make the submission process streamlined. From design controls and quality system integration to the importance of human factors validation and international considerations, this episode is packed with practical advice for any company entering or expanding in the combination product space. 

What's on Craigslist? 6-16-2025 …Gay Man seeks Straight Woman for Family Picnic …Woman Seeks Man to Marry Immediately …Woman seeks Woman (Vomiting Okay) …It's a Combination, Brass Knuckles-Jesus/Taco Holder/Butt Plug

Dr. Casey Grover explores the history, neuroscience, and treatment approaches for methamphetamine use disorder, highlighting how methamphetamine releases more dopamine than any other known substance.• Methamphetamine was widely used during World War II by German, Japanese, and Allied forces to enhance performance• Modern meth production shifted from ephedra to P2P method, creating cheaper, more potent meth with worse psychiatric effects• Meth causes dopamine release up to 1,400 ng/dL of dopamine compared to cocaine (400), sex (200), and food (150), severely damaging reward centers• Many methamphetamine users have undiagnosed ADHD and are inadvertently self-medicating• Effective medications include bupropion, topiramate, atomoxetine, viloxazine, guanfacine, and mirtazapine• Contingency management (reward-based incentives) shows significant efficacy for methamphetamine addiction treatment• Combination therapies using bupropion with naltrexone show promise for reducing meth use• Treating underlying mental health conditions and providing housing/social support remains essential for recoveryTo contact Dr. Grover: ammadeeasy@fastmail.com

The side topic today for the 94 WIP Morning Show: what's the best combination of TV and movie role for example, Michael J. Fox as Marty McFly in Back to the Future as well as Alex P Keaton in Family Ties.

If you've ever wondered what a combination product is—or how to explain it—this video breaks it down clearly and simply. This is a non-technical, high-level explanation of what a combination product is. It's meant for anyone who works in or around pharma, medtech, or biotech and wants a clear, shareable reference—without getting into detailed regulatory definitions or region-specific nuances.I'm Subhi Saadeh, and I've spent my career in drug-device combination products. In this short reference video, I walk through:- What defines a combination product- Two key factors: primary mode of action and how components are combined- The difference between drug-led and device-led products- Examples of single-entity, co-packaged, and cross-labeled products00:00 Introduction to Drug Device Combination Products00:31 Defining Combination Products00:54 Philosophical Factors of Combination Products01:10 Drug-Led Combination Products01:51 Device-Led Combination Products02:32 Combination Configurations03:50 Summary and ConclusionAdditional Resources: - 21 CFR Part 4 FDA regulation on Current Good Manufacturing Practice (CGMP) requirements for combination products https://www.ecfr.gov/current/title-21/chapter-I/subchapter-A/part-4- FDA Guidance: Current Good Manufacturing Practice Requirements for Combination Productshttps://www.fda.gov/media/90652/download- FDA Combination Products Overview Page https://www.fda.gov/combination-products- 21 CFR Part 3 Regulations on combination product classification and primary mode of action (PMOA) https://www.ecfr.gov/current/title-21/chapter-I/subchapter-A/part-3- EU MDR Article 117 Requirements for drug-device combinations under the European Medical Device Regulation (Regulation (EU) 2017/745) https://health.ec.europa.eu/system/files/2021-10/md_mdr_2017-745_en_0.pdfSubhi Saadeh is a Quality Professional and host of Let's Combinate. With a background in Quality, Manufacturing Operations and R&D he's worked in Large Medical Device/Pharma organizations to support the development and launch of Hardware Devices, Disposable Devices, and Combination Products for Vaccines, Generics, and Biologics. Subhi serves currently as the International Committee Chair for the Combination Products Coalition(CPC) and as a member of ASTM Committee E55 and also served as a committee member on AAMI's Combination Products Committee.For questions, inquiries or suggestions please reach out at letscombinate.com or on the show's LinkedIn Page.

The Combination of Thomasina Petrus singing in front of the Selby Avenue Brass Band has been very well received. Catch this pairing in a comfortable listening situation, Crooners Supper Club in Fridley, Friday evening June 13 from 8 till 9:30. The leader of the Selby Avenue Brass Band is Tom Wells. Tom and Thomasina met with Phil Nusbaum to talk about the show, and first, Tom talked about the quality of the ensemble playing on a piece called Selby Strut.

This week on The Game Marks Podcast we are playing Fire Pro Wrestling Combination Tag.  How does the first ever Fire Pro Wrestling game hold up!?Please subscribe and leave a review for this podcast on Apple Podcast and Spotify and follow us on all forms of social media @gamemarkspod.Join George Feis & Johnny Clash each week as they do a #DeepDive into the good, the bad & the awesome of wrestling video games. Do your favorite games stand the test of time or are you playing them with nostalgia goggles? New episodes every other Monday!SponsorsMad Cat Beard Care: madcatbeardcare.com GAMEMARKS for 15% offMerch: podxchange.shopPro Wrestling Tees: prowrestlingtees.com/gamemarkspodTee Public: teepublic.com/user/gamemarkspodWWE Shop: wwe-shop.sjv.io/Qj05r3

In this episode, the guys discuss who they'd take to the bar, followed by a deep dive into the recent House vs. NCAA settlement and its implications for college sports. The conversation shifts to the impact of NIL deals on player recruitment and team dynamics. Once they've settled that once and for all, they jump to the seriously impressive play surrounding the Stanley Cup and NBA Finals. You have to watch these two finals if you're a fan of sport.They jump into the introduction of Supio, a new AI platform for plaintiff law firms. Supio turns case documents into critical insights with the power of AI to help firms work smarter, settle bigger and win more in court.They celebrate Coco Gauff's rise in women's tennis, marking her as a significant figure in the sport. In this conversation, the hosts discuss various themes in sports, focusing on women's tennis rivalries, the current state of men's American tennis (while wondering where the American male tennis champions have all gone), and the impact of coaching changes in the NBA and NHL. Assembly Software is a huge part of how the guys keep this show going. It's known for its leading case management product, TrialWorks, and its cloud-based solution, Neos. Neos allows law firms to access everything on the road and now features an AI program to enhance efficiency in tasks like drafting letters. Check out AssemblySoftware.com for more information.Last, they go on a mission to figure out what is in the minds of the Pittsburgh Steelers' management, and examine their quarterback "situation". They preview the US Open golf tournament, highlight the excitement of the College World Series, and address fan behavior in tennis matches.And of course the show would not be complete without Injury Board, an exclusive networking and marketing firm that connects and refers cases among the best plaintiffs' lawyers in the country. If you're a leader in your community and at the bar, consider checking out InjuryBoard.org for membership and referral opportunities.And If you're looking for a company to develop your website and digital marketing, Digital Law Marketing offers exclusive regional partnerships, unlike other companies that might prioritize marketing competitors. Their proven results have led to significant increases in organic originations. Go to DigitalLawMarketing.com for details.

Despite a bonus point win over Northampton on the final day, Gloucester missed out on the playoffs by 2 points - finishing 5th overall. We discuss the game and Snowy provides his Season Review (we all do the same over the coming weeks). We also discuss the Combination Cup finals day; the results and the games but also the unfortunate incident involving Longlevens and Matson 'supporters'. Finally we chat about the recently announced plans for an alternative R360 competition headed up by Mike Tindall and former Bath DOR Stuart Hooper.Ed PriceJames Eastwood (Snowy)Jim HarleyCherry Jam is proud to be sponsored by PGT LLP

The principal theme of this podcast episode centres on the notion that mere job performance is insufficient for career advancement. I engage in a dialogue with Andrea Wasserman, founder of Executive Express, who elucidates the invisible rules that govern professional progression, particularly for new graduates. Andrea emphasizes the critical importance of communication and executive presence, asserting that individuals must actively showcase their achievements to cultivate recognition in increasingly competitive environments. Furthermore, we explore the concept of "style flexing," which entails adapting one's approach based on the dynamics of the workplace. This conversation serves as a vital resource for listeners seeking to enhance their influence and navigate the complexities of career development effectively.Links referenced in this episode:theexecutiveexpress.comlinkedin.com/in/andreawassermaninstagram.com/theexecutiveexpresstiktok.com/@theexecutiveexpresssubstack.com/@theexecutiveexpressWant help creating your own podcast? Visit us at podjunction.com or reach out to Sadaf directly on LinkedIn: https://www.linkedin.com/in/sadafbeynon/

Hour 1 of the Tuesday Bob Rose Show, with the latest on lefty media outrage over the terror attack in Colorado and false report of violence at Gaza food distributions. Former DOJ official Andrew McCabe is caught again on the wrong side of facts, as CNN's disinformation coverage tanks the network's ratings. Plus the morning's breaking news for 6-3-25

Accuweather meteorologist Jeff Nordeen joins Chris and Amy as the region's air quality is being impacted this week.

Marcus and Corey What You Know 'Bout That trivia game for Thursday May 15th, 2025.

• Intro• Xbox-Branded ROG Ally Leaks• SteamOS Game Verification Announced• The BACKLOG• Nintendo Gives Themselves Permission to Brick Your Switch• Switch 2 May Be Recording Your Audio and Voice Chats• Nintendo Estimates 15 Million Switch 2 Consoles Sold• 2025 Video Game Hall of Fame Inductees• Palworld Confirms Changes Due to Nintendo Lawsuit• Mafia: The Old Country Trailer and Release Details• Indiana Jones Now Steam Deck Verified• GTA VI Trailer a Combination of Cutscene and Gameplay• TWEET OF THE WEEK• Q&AOriginally streamed on May 13, 2025

https://youtu.be/rADiqnrhgrk Adam Coughlin, Co-founder, CMO, and Managing Partner of York IE, is on a mission to help startups beat the odds by building strong, capital-efficient brands that resonate with their markets. We explore Adam's Drumbeat Marketing Framework:Messaging & Positioning, Develop Unique Point of View, Execution, and Scorekeeping.He shares why brand consistency beats shiny-object syndrome, how vertical AI is redefining SaaS, and why startups need to balance storytelling with measurable impact. Adam also explains how to foster entrepreneurial thinking early and why founders must lead with a deep sense of purpose. --- Run Through Walls with Adam Coughlin Good day, dear listeners, Steve Preda here with the Management Blueprint Podcast. And my guest today is Adam Coughlin, co-founder, CMO and managing partner of York IE, where he works with startups on foundational messaging, content, communications, go-to-market strategy, website and digital marketing, revenue operations, and corporate storytelling. Welcome to the show, Adam. Yeah, thanks for having me, Steve. Appreciate it. Yeah, you guys are really a full-service shop. You do almost everything. So tell me, how are you guys unique, and what is it that makes you a superior solution for people? Yeah, absolutely. So the founding team of York IE, we all work together at a company called Dine here in New Hampshire that did the domain name system. And we built that company to about a hundred million of annual recurring revenue, got acquired by Oracle. While we were inside of Oracle, we kind of reflected on the growth journey that we took at Dine. And we felt that a lot of the legacy institutions that we turned to for growth help, whether that was our investors, our advisors, our vendors, they were operating out of antiquated models so that were really good for them, but not necessarily for us as the operators. And so that's what we wanted to disrupt. So in 2019, we launched York IE. We are an advisory and investment firm. So we help technology companies grow. We do that through investing in early stage exclusively B2B software companies. And then because we were operators, we also built a strategic advisory firm that does strategy and execution across the functional areas of R&D, go to market and G&A. Because we feel like we want to roll up our sleeves and help companies be successful.Share on X Yeah. So you're basically investing companies that advise them, help to improve them, and some you just advise them and don't invest. So it's a combination. Combination. Exactly. Right. And I think in addition to the advise, it's really important to get across that we do the execution because that is where companies need help. Especially early stage companies. A lot of those teams are small, they're dynamic, they have a good strategy, they just need help and take some things off their plates and we're there to help them with that. Sounds great. So that leads to my question. What is your personal “Why” and how are you manifesting it in your business? Yeah, absolutely. I think this is a great question. And my personal “Why” is I love entrepreneurs. I think that they are both visionary and builders and that they are pursuing their dreams in the effort to create something and build something that makes the world better. And I think that if they build good companies, then they hire good employees. Good companies have impacts on communities. Good companies build wealth.Share on X But unfortunately, the numbers are stacked against them. A large majority of startups fail, and I don't think that needs to be the case. And that's what I want to try to impact. If we can lower those numbers a little bit and help more founders and entrepreneurs succeed, then we're going to have a really positive impact on things because of all the good things that come from that success. Yeah, well, I couldn't resonate more with that.

Andy Smith, a heavy drinker all his life, everything fell apart for Andy as a 50 year old father of three. Redemption came from a very strange place! A Michael Jackson song started a journey of self-discovery that led him to get on his bike for charity - riding up Mt Everest, the course of the Tour de France and across the Arctic Circle. Andy now helps others, and speaks regularly on what his sobriety journey has taught him, and how it prepared him to push beyond his own self-imposed limitations.Website - https://www.soberinseven.com/LinkedIn - https://www.linkedin.com/in/thatandysmithFacebook - https://www.facebook.com/soberinsevenTwitter - https://twitter.com/soberinsevenYouTube - https://www.youtube.com/c/SoberinSevenInstagram - https://www.instagram.com/soberinsevenMaster of Your Crafts is a captivating podcast featuring conversations with individuals who have dedicated themselves to mastering their craft. Whether it's a gift, talent or skill that comes naturally to them, these individuals have taken ownership and honed their abilities to perfection. Through deep conversation, we delve into their inner dialogue, actions and life circumstances offering words of wisdom to empower and guide you on a journey to becoming the master of your own craft.For more information, visit our website https://masterofyourcrafts.com and Bright Shining Light Website: https://brightshininglight.comStay connected with us:- Facebook: https://www.facebook.com/masterofyourcrafts- Instagram: https://www.instagram.com/MasterOfYourCrafts/- Spotify: https://open.spotify.com/show/1M0vp9HoK7kkP1w4ij7PJd?si=7d383a92b93b4e2c- ApplePodcast: https://podcasts.apple.com/ca/podcast/master-of-your-crafts/id1512818795- Amazon Music: https://music.amazon.ca/podcasts/b15079de-bc6a-487c-b8f8-faca73d0f685/master-of-your-crafts- Google Play: https://podcasts.google.com/feed/aHR0...

(4/30/2025-5/6/2025) Combination order. Tune in.#applepodcasts⁠ ⁠#spotifypodcasts⁠ ⁠#youtube #amazon⁠ ⁠#patreon⁠patreon.com/isaiahnews

Ashley has been seeing this girl for a little bit now... but Ashley was a little taken back when she said she was going to the grocery store to pick up a few of these items... See omnystudio.com/listener for privacy information.

Ashley has been seeing this girl for a little bit now... but Ashley was a little taken back when she said she was going to the grocery store to pick up a few of these items...

Contributor: Aaron Lessen, MD Educational Pearls: What is a Rescue Inhaler? A rescue inhaler is a medication for people with asthma to quickly reverse the symptoms of an asthma attack. Historically albuterol (Short Acting Beta Agonist (SABA)) monotherapy has been the mainstay rescue inhaler. This is because albuterol works fast and is relatively cheap. What are Combination Rescue Inhalers? Combination rescue inhalers contain a fast-acting bronchodilator as well as an inhaled corticosteroid (ICS) The steroid helps to reduce some of the chronic airway inflammation that is worsening the asthma attack and can help to prevent future attacks Examples include budesonide-formoterol and albuterol-budesonide Global Initiative for Asthma (GINA), states that combination therapy is now the preferred reliever for adults and adolescents with mild asthma What are the drawbacks of Combination Rescue Inhalers? These inhalers are generally more expensive than just using a SABA inhaler which can be a barrier for some people Improper use can also lead to conditions like thrush due to the addition of the steroid References Krings JG, Beasley R. The Role of ICS-Containing Rescue Therapy Versus SABA Alone in Asthma Management Today. J Allergy Clin Immunol Pract. 2024 Apr;12(4):870-879. doi: 10.1016/j.jaip.2024.01.011. Epub 2024 Jan 17. PMID: 38237858; PMCID: PMC10999356. Papi A, Chipps BE, Beasley R, Panettieri RA Jr, Israel E, Cooper M, Dunsire L, Jeynes-Ellis A, Johnsson E, Rees R, Cappelletti C, Albers FC. Albuterol-Budesonide Fixed-Dose Combination Rescue Inhaler for Asthma. N Engl J Med. 2022 Jun 2;386(22):2071-2083. doi: 10.1056/NEJMoa2203163. Epub 2022 May 15. PMID: 35569035. Summarized by Jeffrey Olson, MS3 | Edited by Jorge Chalit, OMS3 Donate: https://emergencymedicalminute.org/donate/  

AUA2025: PARP-Inhibitor Combination Treatments for the Urologic Care Team CME Available: https://auau.auanet.org/node/42822 At the conclusion of this CME activity, participants will be able to: 1. Apply the mechanism of action of PARP inhibitors and the rationale for using them in patients with advanced prostate cancer. 2. Recognize the role and importance of genetic testing in patients with mCRPC and the implications of germline mutations on response to therapy. 3. Identify best practices and utilize available guidelines for patients with mCRPC to optimize treatment success and oncologic outcomes. 4. Recognize when to use PARP inhibitors as monotherapy, the rationale and indications for combination therapy, and appropriate treatment sequencing. 5. Successfully counsel patients on the possible adverse events associated with PARP inhibitor therapies alone or in combination. ACKOWLEDGEMENTS Support provided by independent educational grants from: AstraZeneca Merck & Co., Inc.

GraphBI: Expanding Analytics to All Data Through the Combination of GenAI, Graph, & Visual Analytics // MLOps Podcast #310 with Paco Nathan, Principal DevRel Engineer at Senzing & Weidong Yang, CEO of Kineviz.Join the Community: https://go.mlops.community/YTJoinIn Get the newsletter: https://go.mlops.community/YTNewsletter // AbstractExisting BI and big data solutions depend largely on structured data, which makes up only about 20% of all available information, leaving the vast majority untapped. In this talk, we introduce GraphBI, which aims to address this challenge by combining GenAI, graph technology, and visual analytics to unlock the full potential of enterprise data.Recent technologies like RAG (Retrieval-Augmented Generation) and GraphRAG leverage GenAI for tasks such as summarization and Q&A, but they often function as black boxes, making verification challenging. In contrast, GraphBI uses GenAI for data pre-processing—converting unstructured data into a graph-based format—enabling a transparent, step-by-step analytics process that ensures reliability.We will walk through the GraphBI workflow, exploring best practices and challenges in each step of the process: managing both structured and unstructured data, data pre-processing with GenAI, iterative analytics using a BI-focused graph grammar, and final insight presentation. This approach uniquely surfaces business insights by effectively incorporating all types of data.// BioPaco NathanPaco Nathan is a "player/coach" who excels in data science, machine learning, and natural language, with 40 years of industry experience. He leads DevRel for the Entity Resolved Knowledge Graph practice area at Senzing.com and advises Argilla.io, Kurve.ai, KungFu.ai, and DataSpartan.co.uk, and is lead committer for the pytextrank​ and kglab​ open source projects. Formerly: Director of Learning Group at O'Reilly Media; and Director of Community Evangelism at Databricks.Weidong YangWeidong Yang, Ph.D., is the founder and CEO of Kineviz, a San Francisco-based company that develops interactive visual analytics based solutions to address complex big data problems. His expertise spans Physics, Computer Science and Performing Art, with significant contributions to the semiconductor industry and quantum dot research at UC, Berkeley and Silicon Valley. Yang also leads Kinetech Arts, a 501(c) non-profit blending dance, science, and technology. An eloquent public speaker and performer, he holds 11 US patents, including the groundbreaking Diffraction-based Overlay technology, vital for sub-10-nm semiconductor production.// Related LinksWebsite: https://www.kineviz.com/Blog: https://medium.com/kinevizWebsite: https://derwen.ai/pacohttps://huggingface.co/pacoidhttps://github.com/ceterihttps://neo4j.com/developer-blog/entity-resolved-knowledge-graphs/~~~~~~~~ ✌️Connect With Us ✌️ ~~~~~~~Catch all episodes, blogs, newsletters, and more: https://go.mlops.community/TYExploreJoin our slack community [https://go.mlops.community/slack]Follow us on X/Twitter [@mlopscommunity](https://x.com/mlopscommunity) or [LinkedIn](https://go.mlops.community/linkedin)] Sign up for the next meetup: [https://go.mlops.community/register]MLOps Swag/Merch: [https://shop.mlops.community/]Connect with Demetrios on LinkedIn: /dpbrinkmConnect with Weidong on LinkedIn: /yangweidong/Connect with Paco on LinkedIn: /ceteri/

The combination of Brown Noise and Pink Noise offers a harmonious blend of soothing deep tones and balanced frequencies, creating a rich auditory environment perfect for relaxation and focus. Brown Noise, with its emphasis on low-frequency sounds, brings a grounding, almost earthy hum that resonates deeply, providing a calming and enveloping atmosphere. It's ideal for those seeking to unwind or drown out low-level background distractions. Pink Noise, in contrast, incorporates a balanced mixture of both high and low frequencies, creating a sound more natural and gentle compared to White Noise. It's often compared to the sound of rainfall or wind rustling through trees—soothing yet with a little more complexity than Brown Noise. Together, Brown Noise and Pink Noise work in perfect synergy, offering a peaceful and immersive experience that is ideal for promoting sleep, meditation, or concentration. ❗ ❗ To support this podcast and unlock all the ad-free and intro-free episodes, along with other benefits, SUBSCRIBE at ⁠⁠https://12hourwhitenoise.supercast.com⁠⁠ ❗ ❗Although there may be an ad or two at the very beginning of this free episode, you can rest assured that there will be no further interruptions or ads once the Sleep Sound begins

Warriors Head Coach Steve Kerr joined Willard & Dibs to discuss the Jonathan Kuminga situation, the upcoming playoff series against the Rockets, and why Jimmy Butler reminds him of Andre Iguodala.

Send us a message with this link, we would love to hear from you. Standard message rates may apply.Managing allergic rhinitis requires realistic expectations and a strategic approach to medication. Though no treatment will completely eliminate symptoms, the right combination of therapies can significantly reduce discomfort and improve quality of life during allergy season.• Nasal corticosteroid sprays are first-line treatments that reduce inflammation in nasal passages• Proper technique matters: point spray toward outside of nostril and sniff gently "like smelling a flower"• Non-sedating antihistamines (Zyrtec, Claritin, Allegra) relieve itching, sneezing, and runny nose without drowsiness• Nasal antihistamine sprays provide targeted relief and can start working within minutes• Oral decongestants raise concerns about blood pressure and heart rate increases• Avoid nasal decongestant sprays (like Afrin) beyond 2-3 days to prevent rebound congestion• Combination therapies often work better than single medications• Consider allergen immunotherapy when standard treatments don't provide adequate reliefThank you for coming back to another episode of Your Checkup. Hopefully you were able to learn something for yourself, a loved one, or an allergic neighbor. Please check out our website, find us on Instagram, send us an email at yourcheckuppod@gmail.com and, most importantly, stay healthy my friends, until next time.Support the showSubscribe to Our Newsletter! Production and Content: Edward Delesky, MD & Nicole Aruffo, RNArtwork: Olivia Pawlowski

Brett Veach and Andy Reid legitimately may be the best GM/HC combination in all of sports ever. WE ARE LUCKY.

Both the Jaredits and Nephites were destroyed by secret combinations. Both Mormon and Moroni speak of secret combinations in our day. Modern revelation speaks of a very specific secret combination that has shown to have a devastating impact on those of us living in the latter-days.

This week's final episode this season of the Pinning Combination podcast with The Gazette's K.J. Pilcher and Dick Briggs wraps up the Iowa college wrestling season.

In this research-packed episode, Dr. Scott Watier and Tommy Welling analyze groundbreaking findings from a network meta-analysis that evaluates the most effective combinations of fasting styles and exercise types for weight loss. The study's surprising conclusion reveals that alternate-day fasting paired with moderate-intensity continuous training significantly outperforms other approaches, scoring an impressive 88% effectiveness for weight loss and 93% for fat mass reduction. The hosts break down why this combination works so well—explaining how it enhances metabolic flexibility, improves insulin sensitivity, and promotes sustainable fat oxidation—while debunking common misconceptions about needing high-intensity workouts for optimal results. They provide practical guidance for implementing these evidence-based strategies, emphasizing that consistent moderate exercise (like zone 2 training) combined with strategic longer fasting windows delivers superior outcomes with better long-term adherence than traditional approaches. Whether you're just starting your fasting journey or looking to optimize your current routine, this episode offers clear, actionable insights backed by the latest scientific research. Take the NEW FASTING PERSONA QUIZ! - The Key to Unlocking Sustainable Weight Loss With Fasting! Resources and Downloads: SIGN UP FOR THE DROP OF THE ULTIMATE GUIDE TO BLOOD SUGAR CONTROL GRAB THE OPTIMAL RANGES FOR LAB WORK HERE! - NEW RESOURCE! - December 2024 FREE RESOURCE - DOWNLOAD THE NEW BLUEPRINT TO FASTING FOR FAT LOSS! SLEEP GUIDE DIRECT DOWNLOAD DOWNLOAD THE FASTING TRANSFORMATION JOURNAL HERE! Partner Links: Get your FREE BOX OF LMNT hydration support for the perfect electrolyte balance for your fasting lifestyle with your first purchase here! Get 30% off a Keto-Mojo blood glucose and ketone monitor (discount shown at checkout)! Click here! Our Community: Let's continue the conversation. Click the link below to JOIN the Fasting For Life Community, a group of like-minded, new, and experienced fasters! The first two rules of fasting need not apply! If you enjoy the podcast, please tap the stars below and consider leaving a short review on Apple Podcasts/iTunes. It takes less than 60 seconds, and it helps bring you the best original content each week. We also enjoy reading them! Article Links: https://storage.googleapis.com/msgsndr/6JyvZbS9DGozfkVmE452/media/67bf3a92ed60db2f5765f5e3.pdf

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