Podcasts about Pisa

Jen Denton and Pastor Jeff Cranston discuss how salvation is based on Christ and the believer's service to Christ. Paul likens these to gold and silver and precious stones and says that there are two types of structures built on Christ- the first being built on gold silver or precious stones, which will endure and be rewarded, while the second is built on wood hay or stubble, which will suffer loss. Christians are secure in their salvation because they are building on Christ, which is the rock. Christ himself is the foundation on which the Christian stands, and on which they build their eternal life. [00:01 - 06:47] Opening SegmentQuick fun chat about the Leaning Tower of Pisa[06:48 - 16:52] The Believer's FoundationMatthew 7:24-27Corinthians 3:9-15Salvation is based upon Christ the rockService to Christ is built on the foundation of ChristPaul likens this to gold, silver, and precious stones, but says that another class of structure is built on the rock--wood hay and stubbleChrist is the foundation on which Christians stand, and on which they build their lives and eternity.[16:53 - 18:38] Closing SegmentSalvation occurs instantaneously at the moment of salvation when we are placed upon Christ as a solid rockQuotes:“Christ is the foundation on which the Christian stands and on which the Christian builds.” - Pastor Jeff CranstonJoin the ConversationWe love your feedback! If you enjoyed this episode, leave us a review. If you have any questions or comments on today's episode, email me at pastorjeff@lowcountrycc.org.Visit my website https://www.jeffcranston.com and subscribe to my newsletter. Join me on Sunday mornings at LowCountry Community Church. Check-in with us on Facebook or Instagram @pastorjeffcranstonRemember, the real power of theology is not only knowing it but applying it. Thanks for listening!Remember, the real power of theology is not only knowing it but applying it. Thanks for listening!

Subscribe to Quotomania on Simplecast or search for Quotomania on your favorite podcast app!Carlo Ginzburg (1939) has taught at the University of Bologna, at UCLA, at the Scuola Normale of Pisa. His  books, translated into more  than twenty languages, include The Night Battles; The Cheese and the Worms; Clues, Myths, and the Historical Method; The Enigma of Piero della Francesca; History, Rhetoric, and Proof; The Judge and the Historian; Wooden Eyes; No Island is an Island; Threads and Traces; Fear Reverence Terror: Five Essays in Political Iconography.  He received the Aby Warburg Prize (1992), the Humboldt-Forschungs Prize (2007), the Balzan Prize for the History of Europe, 1400-1700 (2010) and sixteen honorary degrees from different universities. From https://history.ceu.edu/people/carlo-ginzburg. For more information about Carlo Ginzburg:Previously on The Quarantine Tapes:Elif Shafak about Ginzburg, at 06:55: https://quarantine-tapes.simplecast.com/episodes/the-quarantine-tapes-025-elif-shafakJorie Graham about Ginzburg, at 10:45: https://quarantine-tapes.simplecast.com/episodes/the-quarantine-tapes-139-jorie-grahamThe New History: Confessions and Conversations: https://www.wiley.com/en-us/The+New+History%3A+Confessions+and+Conversations-p-9780745630212“Being Jewish, Becoming Jewish: Carlo Ginzburg in Conversation with Paul Holdengräber”: https://www.youtube.com/watch?v=gM5RIFd8mjE“Interview with Carlo Ginzburg”: https://www.versobooks.com/blogs/4460-there-is-always-in-history-this-possibility-of-the-unexpected-interview-with-carlo-ginzburg

L'apertura di giornata, con le notizie e le voci dei protagonisti. Desta preoccupazione uno studio del Ministero della Salute su batterio "Listeria" che, negli ultimi 3 anni, avrebbe provocato 3 vittime e oltre 60 casi accertati nel nostro paese. Alla base di questo focolaio ci sarebbe il consumo di würstel crudi di carne avicola prodotti in uno stabilimento veronese e venduti con diversi marchi. Ne parliamo con Mauro Pistello, direttore dell'Unità di virologia dell'azienda ospedaliera universitaria di Pisa, e professore di microbiologia all'Univ. di Pisa.

When Derrick's physics textbook meets with an unfortunate accident, Nanny Piggins fills in and tells Derrick everything he needs to know about the great physicist and astronomer - Galileo of Pisa.Support the show at https://www.buymeacoffee.com/storiesrasprattSupport the show

Show Notes: InSight hears meteoroid impacts on Mars | EarthSky (01:15) Since 2018, NASA's InSight lander has been busy studying the interior of Mars detecting  over 1,300 marsquakes NASA announced on September 19, 2022, that, for the first time, InSight has heard the impacts of four meteoroids as they crashed into the Martian surface. Detected the vibrations from the impacts in 2020 and 2021. The impacts produced small marsquakes, up to a magnitude of 2.0.  This is the first time that InSight – or any Mars lander or rover – has ever detected the seismic waves from a meteoroid impact. The four impacts occurred between 53 and 180 miles from InSight's location in Elysium Planitia.  Elysium Planitia, a flat-smooth plain just north of the equator making it a great location to study the Martian interior.  NASA's Mars Reconnaissance Orbiter took images of the impact sites from orbit.  Appeared as dark spots in the orbiter's black-and-white Context Camera.  The seismic waves generated by the impacts can give scientists clues about both the impacting rocks and the Martian subsurface. Additionally, scientists can use impact craters to determine the age of the surface. More craters = Older the surface is By using both InSight's data and orbital images of the impact craters, researchers can determine the meteoroid's trajectory and size of its shock wave (seismic wave).  7,000-year-old structure near Prague is older than Stonehenge, Egyptian pyramids | Live Science (05:27) Archaeologists digging near Prague have discovered the remains of a Stone Age structure that's older than Stonehenge and even the Egyptian pyramids: an enigmatic complex known as a roundel.  7,000 years ago during the late Neolithic, or New Stone Age Viewed from above, roundels consist of one or more wide, circular ditches with several gaps that functioned as entrances.  "Roundels are the oldest evidence of architecture in the whole of Europe," according to Jaroslav Řídký, a spokesperson for the Institute of Archaeology of the Czech Academy of Sciences (IAP). Radio Prague International reported, the excavated roundel is large — about 180 feet (55 meters) in diameter, or about as long as the Leaning Tower of Pisa is tall Clear that this was part of the Stroked Pottery culture, which flourished between 4900 B.C. and 4400 B.C.  Located in the Bohemian region of the Czech Republic Many farming villages found near the intersection of contemporary Poland, eastern Germany and the northern Czech Republic  Carbon-dating organic remains from this roundel excavation could help the team pinpoint the date of the structure's construction and possibly link it with a Neolithic settlement discovered nearby. Watch this team of drones 3D-print a tower | MIT Technology Review (09:03) A mini-swarm's worth of drones have been trained to work together to 3D-print some simple towers. Could, one day, help with challenging projects such as post-disaster construction or even repairs on buildings that are too high to access safely. The process has multiple drones work together to build from a single blueprint, with one essentially checking the others' work as it goes. Inspired by the way bees or wasps construct large nests To demonstrate the drones' capabilities, the researchers got them to use foam and a special lightweight form of cement to build structures with heights ranging from 0.18 meters to 2.05 meters.  The technique is limited for now because drones struggle to carry heavy loads, need regular charging, and still require human supervision. The researchers are hoping to alleviate some of these issues by automating the charging of drones during projects World's largest geothermal lagoon planned for Canada | New Atlas (14:12) A project, called geoLagon, is underway in Canada for a magnificent new open air lagoon in Canada that will be kept at balmy temperatures year round through a “huge Thermos” heating system underneath.  Designed to be the largest of its type in the world Modeled on the famous geothermal lagoons of Iceland, the geoLagon is designed as an open-air attraction for visitors to relax and soak up the surroundings. To be built in Charlevoix, Quebec,  span some 12,000 square meters (130,000 sq ft)  warmed to a pleasant 39 °C (102 °F) all year It will be heated through an energy ecosystem consisting of geothermal, biomass, photovoltaics and solar heating systems, along with a thermal reservoir beneath the lagoon's base to store heat. Clusters of chalets will surround the lagoon once the project is completed, capturing solar energy with photovoltaic cladding to help run the heat pumps for the water. CEO Louis Massicotte says that further optimizations and technologies like sewer heat recovery could see the geoLagon village even become an energy provider, but is positive that the project will at the very least be able to sustain itself without drawing power from the grid. The project is planned in three stages, beginning with the construction of 150 solar-powered cottages, followed by the lagoon as the second stage and then the remaining 150 chalets thereafter. Expected to get underway in March and should take around 18 months. Israeli researchers managed to produce 3D printer ink to make wooden objects | Interesting Engineering (18:29) This Wood Ink is made from a mixture of wood flour and plant extracts. Doron Kam, a Ph.D. student working on the project, and colleagues developed this technology at the Hebrew University of Jerusalem. The technology converts organic "wood derivatives" into a paste that is then used as ink by a 3D printer.  The scientists have so far used 3D printing to construct saddle, dome, and helix-shaped models out of their wood-infused ink. They think it might be used to make more sophisticated self-assembling products like furniture. What is the plan for this material, according to Doron Kam: “We are trying to make a material that won't last forever, that's what plastic is for. We are not looking for that … Three or four years of use, and then you can grind it down and print it again. This is sustainability in our product, this is our principle.” 

Il mio libro "Capire il tempo e lo spazio": https://amzn.to/2UYMToT Il mio libro "A cavallo di un protone": https://amzn.to/2LIkz5x In questo episodio capiamo cosa sono le onde gravitazionali e come funziona un'antenna gravitazionale come quella di LIGO, negli Stati Uniti, e quella di Virgo, vicino a Pisa. Il canale YouTube di Pepite: https://www.youtube.com/c/NuggetsofScience La web di Pepite: www.pepitediscienza.it Per approfondire il tema delle onde gravitazionali e della relatività generale: Simone Baroni, “Capire il tempo e lo spazio”, https://amzn.to/2UYMToT B.P.Abbot et al, Physical Review Letters, 116, 061102, 2016

In this first of three episode, I go into depth about the first few days of my trip in Italy! There's so much to do and see in these three cities and hopefully I can do them justice. Listen in to find out what tickets you need in advance, which tickets you have to buy at the gate, and what I think is one of the best kept secrets of visiting the Leaning Tower of Pisa!

Op der Sich no de markante Grenzbornen tëscht der Belsch a Lëtzebuerg Se sinn knapp dräi Meter héich an et gëtt se just laanscht zwou Grenzen op der Welt. Op engem groussen Deel vun der belsch-lëtzebuerger Grenz goufe gosse Grenzmaarken opgestallt. Am neie Pisa Summerchallenge wëllen den Olivier Catani a Mister Science déi ganz Grenz befueren an op mannst 100 vun den imposante Maarke fannen. De Gros dovun steet awer net laanscht Weeër, mee matten am Bësch oder a geféierlechen Häng. Wéini goufen d'Marken opgestallt? Wien huet d'Grenz gezunn? A firwat sinn op ville Plaze komesch Zacken dran?

Op der Sich no de markante Grenzbornen tëscht der Belsch a Lëtzebuerg Se sinn knapp dräi Meter héich an et gëtt se just laanscht zwou Grenzen op der Welt. Op engem groussen Deel vun der belsch-lëtzebuerger Grenz goufe gosse Grenzmaarken opgestallt. Am neie Pisa Summerchallenge wëllen den Olivier Catani a Mister Science déi ganz Grenz befueren an op mannst 100 vun den imposante Maarke fannen. De Gros dovun steet awer net laanscht Weeër, mee matten am Bësch oder a geféierlechen Häng. Wéini goufen d'Marken opgestallt? Wien huet d'Grenz gezunn? A firwat sinn op ville Plaze komesch Zacken dran?

Początki wioski sięgają XIII wieku, kiedy była własnością cystersów z Wąchocka. Pisał o nich też słynny Jan Długosz. Tragiczne losy miejscowości związane są z pierwszą i drugą wojną światową, kiedy została praktycznie zrównana z ziemią. Ksany, w gminie Opatowiec są bohaterem kolejnej audycji.

Federico Mioni Direttore di Federmanager Academy, la management school di Federmanager, da anni si occupa di formazione manageriale. Laureatosi in Giurisprudenza e in Scienze politiche, e con un Dottorato di ricerca a Pisa, ha insegnato come docente a contratto presso le Università di Macerata e Parma, con varie pubblicazioni. Nel '90 ha vinto il Premio Roberto Ruffilli per giovani studiosi e il primo premio del Centro di Studi Americani di Roma ('92 e '95), con esperienze di ricerca presso le Università della Virginia e di Princeton e presso la Library of Congress di Washington. Dal 2001 al 2004 è stato Responsabile della Formazione permanente dell'Università Cattolica di Milano, Coordinatore nazionale dei Centri di cultura per lo sviluppo e Coordinatore amministrativo del Cepad, e responsabile organizzativo di 4 corsi di laurea erogati via satellite o in banda larga. Fino al 2011 è stato il Direttore del CIS, la Scuola per la Gestione d'Impresa di Industriali Reggio Emilia. È stato membro dal 2012 al 2015 del CdA di IFEL e fa parte del Board di Centrimark, il Centro di ricerche di Marketing presso l'Università Cattolica. Ora è Direttore di Federmanager Academy, la Management School di Federmanager. È docente presso i Master dello IULM di Milano e dell'Università Cattolica, e ha curato l'edizione italiana di Democrazia in declino. Capire gli USA per capire l'Italia, di Philip Kotler (Il Mulino, 2017). Il suo ultimo libro è Il lavoro di qualità. Come prepararsi alla sfida dell'occupazione, 2018, edito da Guerini Next. Confindustria Energia e Federmanager hanno lanciato questo ciclo di sei seminari, tra ottobre e dicembre 2022, per manager iscritti a Federmanager, in cui saranno trattati temi come la Just Transition per riflettere su opportunità e costi dei processi di decarbonizzazione. Ogni incontro si concluderà con un momento di condivisione, denominato "world cafè decarbonizzato", con esperti dell'energia e i manager provenienti da diversi settori, dal mondo produttivo a quello accademico, dalla ricerca e sviluppo all'associazionismo civile. Siti app, libri e link utili: Sito Federmanager Academy Linkedin Federmanager Academy Facebook Federmanager Academy Progetto di certificazione BeManager Il Manager della sostenibilità energetica È il professionista che assicura la definizione, la gestione e la misurazione di politiche di Impresa volte al perseguimento di obiettivi di Sostenibilità, favorendo la crescita economica e finanziaria e lo sviluppo durevole dell'Azienda orientando le scelte aziendali verso le tematiche ESG (Environmental, Social, Governance), e sviluppando iniziative volte alla valorizzazione del business secondo criteri sostenibili, circolari e responsabili di innovazione e comunicazione che coinvolgano stakeholder, realtà territoriali e istituzioni.

One of the most common gripes that foreigners have about us Tuscans is that we're so proud of our rich history to never miss the chance to sneak it into any conversation. While this has some merit, it would be quite difficult to act any differently. You see, history for us is not a distant thing, something you read in a book. It's literally everywhere around us, sneaking up on you when you least expect it. Need an example? Let's talk about the odd hospital that is just a stone throw's away from the Leaning Tower in Pisa. No matter how impractical and old-fashioned, Pisani love it so much to have delayed for decades its transfer to a more modern facility. They love it so much because it's possibly the oldest in the world, founded almost eight centuries ago. Not only it's very old, but it's the only one in the world that was born out of a massive naval battle and the clash of two giants of European politics who just hated each other. People in Pisa don't care much about the other hospitals in London or Paris that claim to have been around even longer: as far as they're concerned, the Santa Chiara is the template that was used all over Europe to create hospitals as we know them today. That's why this week What's Up Tuscany will bring you back to Pisa to tell you the fascinating story of the hospital born from a battle and why it became an integral part of Pisan identity. Remember it next time a Tuscan will bore the hell out of you with yet another anecdote from a long gone age. History never dies around here - and this is also what makes this land so unique. Let us know if you like this kind of episode or if you'd rather have us talk more about food, wine or the many hidden corners of this land only locals know about. Remember: we're at your service. Drop us a note at the links below: we'd be glad to hear from you!Email: podcast@larno.itFacebook: https://www.facebook.com/larno.itTwitter: @arno_it / @WhatsupTuscanyLINKS TO SOURCES (ITALIAN ONLY)http://www.stilepisano.it/leggende/leg(g)ende_pisane_N48_battaglia_giglio_19_nov2018.pdfhttp://www.stilepisano.it/leggende/leg(g)ende_pisane_N49_nascita_ospedale_20_nov2018.pdfhttps://www.lanazione.it/cronaca/santa-maria-nuova-l-ospedale-pi%C3%B9-antico-del-mondo-compie-732-anni-1.5245465BACKGROUND MUSICPipe Choir - Bom Bom Breakthrough (Instrumental)Pipe Choir - A dark Blue Arc (Instrumental)Pipe Choir - Children of the SonPipe Choir - Talk to MePipe Choir - Mapping the StarsProfound Beats - Lo-FiWayne John Bradley - Blues Rock Original InstrumentalAll released under Creative Commons Attribution 4.0 International Licensehttps://soundcloud.com/pipe-choir-2/pipe-choir-bom-bom-breakthrough-creative-commons-instrumentalhttps://soundcloud.com/pipe-choir-2/pc-one-a-dark-blue-arc-creative-commons-instrumentalhttps://soundcloud.com/pipe-choir-2/pc-one-children-of-the-son-creative-commons-instrumentalhttps://soundcloud.com/pipe-choir-2/pipechoir-talk-to-me-instrumentalwavhttps://soundcloud.com/pipe-choir-2/pipe-choir-mapping-the-stars-instrumentalhttps://soundcloud.com/profoundbeats/profound-beats-lo-fi-free-downloadhttps://soundcloud.com/ayneohnradley/blues-rock-original-instrumentalcreative-commonshttp://www.pipechoir.com/

A sentire i foresti, una delle cose che trovano più irritanti di noi toscani è il fatto che siamo così orgogliosi della nostra ricca storia da non perdere mai l'occasione di parlarne. Se, in effetti, è difficile trovare un popolo che ami con così tanta passione il proprio passato, sarebbe difficile comportarsi in maniera diversa. Il fatto è che per noi la storia non è una roba lontana, che si legge sui libri di scuola. In Toscana è dovunque, impossibile sfuggirle, anche i posti più insospettabili hanno storie affascinanti da raccontare. Cosa dire ad esempio dello strano ospedale a pochi passi dalla Torre Pendente di Pisa? Sebbene sia poco pratico, antiquato e sia quasi impossibile trovare parcheggio, i pisani gli sono così affezionati da storcere la bocca ogni qual volta un reparto viene trasferito nel più moderno ospedale in periferia, a Cisanello. A cosa si deve questo affetto? Forse al fatto che, secondo molti, sarebbe il più antico al mondo, fondato quasi otto secoli fa. A rendere il Santa Chiara ancora più speciale il fatto che sia l'unico al mondo ad essere nato dopo una sanguinosa battaglia navale, ultimo episodio della faida tra due giganti del Medioevo. Ai Pisani non importa molto che ci siano ospedali a Londra o Parigi nati diversi secoli prima; il nosocomio pisano è stato il modello seguito più tardi in tutta Europa per creare gli ospedali come li conosciamo. Ecco perché questa settimana What's Up Tuscany torna a Pisa per raccontarvi la storia affascinante dell'ospedale nato da una battaglia e di come sia diventato parte integrante dell'identità della città. La prossima volta che un toscano vi pianterà un pippone su un evento successo secoli fa, ricordatevi che la storia, dalle nostre parti, non muore mai. Forse, è proprio questo che rende la Toscana unica al mondo. Fateci sapere se questo tipo di episodio vi piace o se preferireste che parlassimo di più di cibo, vino o degli angoli nascosti di questa terra che conosciamo solo noi del posto. Se non vi fate vivi, come facciamo a migliorare? Mandateci un messaggio ai link qui sotto: ci piacerebbe davvero conoscervi!Email: podcast@larno.itFacebook: https://www.facebook.com/larno.itTwitter: @arno_it / @WhatsupTuscanyI LINK ALLE FONTIhttp://www.stilepisano.it/leggende/leg(g)ende_pisane_N48_battaglia_giglio_19_nov2018.pdfhttp://www.stilepisano.it/leggende/leg(g)ende_pisane_N49_nascita_ospedale_20_nov2018.pdfhttps://www.lanazione.it/cronaca/santa-maria-nuova-l-ospedale-pi%C3%B9-antico-del-mondo-compie-732-anni-1.5245465BACKGROUND MUSICPipe Choir - Bom Bom Breakthrough (Instrumental)Pipe Choir - A dark Blue Arc (Instrumental)Pipe Choir - Children of the SonPipe Choir - Talk to MePipe Choir - Mapping the StarsProfound Beats - Lo-FiWayne John Bradley - Blues Rock Original InstrumentalAll released under Creative Commons Attribution 4.0 International Licensehttps://soundcloud.com/pipe-choir-2/pipe-choir-bom-bom-breakthrough-creative-commons-instrumentalhttps://soundcloud.com/pipe-choir-2/pc-one-a-dark-blue-arc-creative-commons-instrumentalhttps://soundcloud.com/pipe-choir-2/pc-one-children-of-the-son-creative-commons-instrumentalhttps://soundcloud.com/pipe-choir-2/pipechoir-talk-to-me-instrumentalwavhttps://soundcloud.com/pipe-choir-2/pipe-choir-mapping-the-stars-instrumentalhttps://soundcloud.com/profoundbeats/profound-beats-lo-fi-free-downloadhttps://soundcloud.com/ayneohnradley/blues-rock-original-instrumentalcreative-commonshttp://www.pipechoir.com/

Stai ascoltando un estratto gratuito di Ninja PRO, la selezione quotidiana di notizie per i professionisti del digital business. Con Ninja PRO puoi avere ogni giorno marketing insight, social media update, tech news, business events e una selezione di articoli di approfondimento dagli esperti della Redazione Ninja. Vai su www.ninja.it/ninjapro per abbonarti al servizio.Meta e Google tagliano i costi e il personale. Entrambe le società cercano di fronteggiare la crisi economica riorganizzando i reparti e concedendo ai lavoratori un certo periodo di tempo per candidarsi ad altri ruoli all'interno dell'azienda. 30 giorni per la società madre di Facebook e 60 per Google. Tecnologie digitali nelle aziende italiane stentano a decollare. Appena il 39% usa il cloud, solo il 18% l'Intelligenza Artificiale (AI) e quasi un'impresa innovativa su due lamenta rallentamenti a causa di carenze di competenze digitali. Lo scenario emerge dal report presentato da Amazon Web Services (Aws) sul ruolo del digitale in Italia e sul possibile impatto economico delle tecnologie. Amazon estende i suoi progetti sulle rinnovabili. Il colosso dell'eCommerce ha annunciato l'espansione del suo portfolio di iniziative legate alle energie rinnovabili a livello globale, incrementando di 2,7 gigawatt (GW) la sua capacità di energia pulita grazie a 71 nuovi progetti legati alle energie rinnovabili. In Italia ne verranno attivati 5 legati ai depositi di smistamento presenti nelle città di Parma, Pisa, Perugia, Palermo e Cagliari.

El Secretario de Obras mencionó que en la escuela primaria Albino García en Iztapalapa se detectaron daños tras el sismo del lunes, sin embargo, la directora del plantel señala que el lugar fue inspeccionado y que no tiene riesgo.

Link al articulo para los incredulos https://www.weforum.org/agenda/2022/09/my-carbon-an-approach-for-inclusive-and-sustainable-cities/ Vlog de analisis de actualidad, economia, política y filosofia liberal. Canal secundario: https://www.youtube.com/channel/UCDZ11FzQIOd_ivYQkhCxLpw -----------------------------------------------------------------------------------------------------------

“Europe calling! Pound speaking! Ezra Pound speaking!” came over the airwaves in more than 100 shortwave broadcasts from Rome, directed toward America during WWII. Ezra Pound was an American ex-pat, poet, and intellectual who was a major figure of the Modernist literary movement in early-to-mid 20th century -- and was also a fascist collaborator and anti-Semite arrested for treason against the United States for his radio broadcasts. See omnystudio.com/listener for privacy information.

I CrossLab sono cinque laboratori interdisciplinari che coprono tutte le aree chiave di industria 4.0, gestiti dal Dipartimento di Ingegneria dell'Informazione dell'Università di Pisa. I laboratori sono aperti alle imprese per supportarle nei processi di innovazione.Dedicheremo una serie di sei puntate ai temi legati all'innovazione per le imprese, raccontando le opportunità attraverso esempi e casi di successo.I Lab sono stati realizzati grazie a un finanziamento del MUR di circa 9 milioni, che ha consentito l'acquisto di attrezzature di altissimo livello e in alcuni casi uniche in Italia. Come ci spiega Andrea Caiti, coordinatore dei CrossLab.Ci sono anche aziende che hanno investito nei Lab, Chiara e Federico vi raccontano l'esperienza di Calearo Antenne Spa, azienda italiana leader nella produzione di antenne per auto, anche quelle della Formula 1, in compagnia del consigliere di amministrazione del gruppo, Eugenio Calearo Ciman. In collaborazione con CrossLab – Laboratori del Dipartimento di Ingegneria dell'Informazione dell'Università di Pisa.

Die Trauerfeierlichkeiten zum Tod der Queen enden heute mit dem Staatsbegräbnis. Die Verkehrsministerinnen und -minister haben heute bei einer Sonderkonferenz über ein Nachfolgeangebot für das 9-Euro-Ticket beraten. Im "Was-Jetzt?"-Update berichtet Sören Götz, ZEIT-ONLINE-Redakteur für Mobilität, von den Ergebnissen. Wie geht es nach dem 9-Euro-Ticket weiter? Außerdem im Update: Klimaaktivistinnen und -aktivisten haben das Kohlekraftwerk Jänschwalde blockiert. Nach Angaben der Polizei wurden erste Personen in Gewahrsam genommen. Was noch? Der schiefste Turm der Welt steht nicht in Pisa. Moderation und Produktion: Constanze Kainz Redaktion: Moses Fendel Mitarbeit: Alma Dewerny Fragen, Kritik, Anregungen? Sie erreichen uns unter wasjetzt@zeit.de. Weitere Links zur Folge: Liveblog: Beerdigung von Queen Elizabeth II:Trauergottesdienst in Westminster Abbey hat begonnen (https://www.zeit.de/politik/ausland/2022-09/staatsbegraebnis-queen-elizabeth-ii-london-live) Queen Elizabeth II: Frank-Walter Steinmeier kondoliert König Charles III. (https://www.zeit.de/politik/ausland/2022-09/queen-elizabeth-ii-frank-walter-steinmeier-koenig-charles-iii) 9-Euro-Ticket: Verkehrsminister treffen sich zu Sonderkonferenz (https://www.zeit.de/politik/deutschland/2022-08/9-euro-ticket-verkehrsminister-sondergipfel-nahverkehr) Braunkohle: Aktivisten nach Blockade an Kohlekraftwerk Jänschwalde in Gewahrsam (https://www.zeit.de/gesellschaft/2022-09/braunkohle-kraftwerk-jaenschwalde-aktivisten-polizei) Was noch: "Schiefster Turm der Welt" steht im rheinhessischen Gau-Weinheim (https://www.swr.de/swraktuell/rheinland-pfalz/mainz/schiefer-turm-gau-weinheim-100.html)

¿Quieres ver la entrevista en vídeo?: https://youtu.be/7iSFcV9IU9o Curso online para cachorros (de 8 semanas a los 5 meses): https://mascotasurbanas.com/cachorro-perfecto/ Enlace del instagram de Nana: @nana.rottweiler Enlace para comprar el libro "Señales de calma" de Turid Rugaas: https://mascotasurbanas.com/productos-recomendad/el-lenguaje-de-los-perros-las-senales-de-calma-tapa-blanda-libro/ Enlace cámara web de vigilancia: https://amzn.to/3AcZlCk En la entrevista de hoy vas a aprender lo que hay que hacer desde el momento en que piensas tener un cachorro y cómo hacer las cosas bien desde el primer minuto que pisa tu casa: - ¿Comprar o adoptar? - ¿Por qué compraste al final? - ¿Qué raza escogiste y por qué? - ¿Pienso o barf? - ¿Cuántos libros leíste sobre perros? ¿Cuál recomiendas? - ¿Cómo nos conociste? ¿Qué es lo que más te gusta de nosotros? - ¿Qué curso hiciste antes de tener a la cachorra? - Normas y límites en casa. - Cómo acostumbré a mi cachorra a estar sola. - Cómo le enseñé la palabra “pipi” para que haga pis cuando tengo prisa. - Habituación a la jaula o transportan y sus beneficios. - Los primeros paseos de nana. - La importancia de la socialización, enseñarle cómo caminar con la correa y crear vínculo con juegos y estando atenta a lo que quiere hacer y lo que no quiere (para no forzarla a nada). - Habituación a niños, mucha gente en un mercado y ¿a qué otros entornos con ruido fuimos? - Habituarle al coche, al agua del mar o del río. - Clave que si no te formas no sabes que tienes que enseñar a tu cachorro: la propiocepción. - Imprescindibles que yo llevo cuando vamos al monte con la perra. - Deja descansar al cachorro todo lo que necesite sin molestarle también aumenta el vínculo. - El problema de la sobreestimulación en los cachorros y perros en general. Un error muy común. - Ayudar al perro a no ser un perro exigente y que reaccione bien al no en cualquier circunstancia. - Tiempo exclusivo de atención hacia el perro con un objetivo educativo y de vínculo. Con 10 o 15 minutos diarios es suficiente. - Acostumbrarle al manejo es esencial para que se deje tocar en el veterinario y se deje echar gotas en los ojos, nos deje mirarle las patas etc. - Las dificultades que tengo ahora que está en la etapa “adolescente”. - Mascotas urbanas: Los traductores humano-perro. - ¿Por qué el perro deja de hacerte caso a partir de los 7 u 8 meses?

Despite the great wealth of amazing things to do and see, most foreigners come to our region firmly determined to get just two things that have very little to do with either art or culture: wine and food. Tuscans moan endlessly about it, especially when said foreigners ask them what is the dish they absolutely have to taste as soon as they land. Easier said than done. Tuscany is so varied that it's really hard to find a specialty that is available everywhere in our region. Maybe there is an exception, though: a winter stew that is very popular all over the Arno valley. Its weird name, "ribollita", is almost synonymous with this land and so popular that restaurants abroad try to charge ridiculous amounts of money for it. This is quite outrageous, considering that this earthy dish is the ultimate comfort food, born out of the very real necessity of feeding a large family with very little money. The history and evolution of this recipe is quite fascinating, especially if you think that it's made of very simple and inexpensive ingredients: cabbage, bread and beans. The ribollita is so famous that it's almost outrageous we have covered Tuscany for almost two years without ever mentioning it. That is why this week What's Up Tuscany will bring you to our very kitchen, where we will tell you everything there is to know about the queen of Tuscan cuisine, its infinite variations and all the advice you might need to recreate this great classic for your family. Beware, though: if you listen to the whole episode you might get really hungry. Let us know if you like this kind of episode or not. Drop us a line on social media or an email. Feedback is always greatly appreciated. We would love to hear from you!Email: podcast@larno.itFacebook: https://www.facebook.com/larno.itTwitter: @arno_it / @WhatsupTuscanyLINKS TO SOURCES (ITALIAN ONLY)https://www.casaagricolarossi.it/lantica-storia-della-ribollita/https://www.gazzettadelgusto.it/cibo-e-storia/ribollita-toscana-storia-origini-natura/https://redacademy.it/la-ribollita/http://www.gastronomiamanzi.it/articolo-zuppa-di-pane-pisana-ribollita/https://www.gazzettadelgusto.it/ricette/primi/ribollita-toscana-di-pellegrino-artusi/BACKGROUND MUSICPipe Choir - Bom Bom Breakthrough (Instrumental)Wayne John Bradley - WaitingWayne John Bradley - Pick you upThe Passion HiFi - BuriedWayne John Bradley - SummercycleWayne John Bradley - Blues Rock Original InstrumentalAll released under Creative Commons Attribution 4.0 International Licensehttps://soundcloud.com/pipe-choir-2/pipe-choir-bom-bom-breakthrough-creative-commons-instrumentalhttps://soundcloud.com/ayneohnradley/waiting-original-uplifting-indie-pop-style-instrumentalcreative-commonshttps://soundcloud.com/ayneohnradley/pick-you-up-slow-poprock-style-instrumental-creative-commonshttps://soundcloud.com/freehiphopbeatsforyou/free-the-passion-hifi-buriedhttps://soundcloud.com/ayneohnradley/summercycle-original-indie-style-instrumental-creative-commonshttps://soundcloud.com/ayneohnradley/blues-rock-original-instrumentalcreative-commonshttp://www.pipechoir.com/

This month on Episode 40 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the September 2 and September 16 issues of the journal. This episode also features an interview with Dr Jun Yoshioka, and Dr Yoshinobu Nakayama, from the City University of New York, about their study, Interaction of ARRDC-4 with GLUT1 Mediates Metabolic Stress in the Ischemic Heart.   Article highlights:   Jin, et al. Gut Dysbiosis Promotes Preeclampsia   Mengozzi, et al. SIRT1 in Human Microvascular Dysfunction   Hu, et al. Racial Differences in Metabolomic Profiles and CHD   Garcia-Gonzales, et al. IRF7 Mediates Autoinflammation in Absence of ADAR1   Cindy St. Hilaire:        Hi, and welcome to Discover CircRes, the podcast of the American Heart Association's journal, Circulation Research. I'm your host, Dr Cindy St. Hilaire from the Vascular Medicine Institute at the University of Pittsburgh. And today I'm going to be highlighting some articles from September 2nd, and September 16th issues of CircRes. And I'm also going to have a conversation with Dr Jun Yoshioka, and Dr Yoshinobu Nakayama, from the City University of New York, about their study, Interaction of ARRDC-4 with GLUT1 Mediates Metabolic Stress in the Ischemic Heart. But, before I get to the interview, I'm going to highlight a few articles.                                       The first article is from our September 2nd issue, and it's titled, Gut Dysbiosis Promotes Preeclampsia by Regulating Macrophages, and Trophoblasts. The first author is Jiajia Jin, and the corresponding author is Qunye Zhang from the Chinese National Health Commission.                                       Preeclampsia is a late-stage pregnancy complication that can be fatal to the mother, and the baby. It's characterized by high blood pressure, and protein in the urine. The cause is unknown, but evidence suggests the involvement of inflammation, and impaired placental blood supply. Because gut dysbiosis can influence blood pressure, and inflammation has been observed in preeclamptic patients, Jin and colleagues examined this link more closely. They found that women with preeclampsia had altered gut microbiome. Specifically, a reduction in a species of bacteria that produced short-chain fatty acids, and lower short-chain fatty acid levels in their feces, in their serum, and in their placentas. And preeclamptic women had lower short-chain fatty acid levels in their feces, in their serum, and in their placentas compared with women without preeclampsia.                                       They found that fecal transfers from the preeclampsia women to rats with a form of the condition exacerbated the animals' preeclampsia symptoms, while fecal transfers from control humans alleviated the symptoms. Furthermore, giving rats an oral dose of short-chain fatty acids or short-chain fatty acid producing bacteria decreased the animals' blood pressure, reduced placental inflammation, and improved placental function. This work suggests that short-chain fatty acids, and gut microbiomes could be a diagnostic marker for preeclampsia. And microbial manipulations may even alleviate the condition.                                       The second article I want to share is also from our September 2nd issue, and it's titled, Targeting SIRT1 Rescues Age and Obesity-Induced Microvascular Dysfunction in Ex Vivo Human Vessels. And this study was led by Alessandro Mengozzi from University of Pisa.                                       With age, the endothelial lining of blood vessels can lose its ability to control vasodilation, causing the vessel to narrow and reduce blood flow. This decline in endothelial function has been associated with age related decrease in the levels of the enzyme, SIRT1. And artificially elevating SIRT1 in old mice improves animals' endothelial function. Obesity, which accelerates endothelial dysfunction, is also linked to low SIRT1 levels.                                       In light of these SIRT1 findings, Mengozzi, and colleagues examined whether increasing the enzyme's activity could improve the function of human blood vessels. The team collected subcutaneous microvessels from 27 young, and 28 old donors. And both age groups included obese, and non-obese individuals. SIRT1 levels in the tissue were, as expected, negatively correlated with age and obesity, and positively correlated with baseline endothelium dependent vasodilatory function. Importantly, incubating tissue samples from older, and obese individuals with a SIRT1 agonist, restored the vessel's vasodilatory functions. This restoration involved a SIRT1 induced boost to mitochondrial function, suggesting that maintaining SIRT1 or its metabolic effect might be a strategy for preserving vascular health in aging, and in obesity.                                       The third article I want to share is from our September 16th issue. And this one is titled, Differences in Metabolomic Profiles Between Black And White Women and Risk of Coronary Heart Disease. The first author is Jie Hu, and the corresponding author is Kathryn Rexrode, and they're from Brigham and Women's Hospital, and Harvard University.                                       In the US, coronary heart disease, and coronary heart disease-related morbidity, and mortality is more prevalent among black women than white women. While racial differences in coronary heart disease risk factors, and socioeconomic status have been blamed, this group argues that these differences alone cannot fully explain the disparity. Metabolomic variation, independent of race, has been linked to coronary heart disease risk. Furthermore, because a person's metabolome is influenced by genetics, diet, lifestyle, environment and more, the authors say that it reflects accumulation of many cultural, and biological factors that may differ by race.                                       This group posited that if racial metabolomic differences are found to exist, then they might partially account for differences in coronary heart disease risk. This study utilized plasma samples from nearly 2000 black women, and more than 4500 white women from several different cohorts. The team identified a racial difference metabolomic pattern, or RDMP, consisting of 52 metabolites that were significantly different between black, and white women. This RDMP was strongly linked to coronary heart disease risk, independent of race, and known coronary heart disease risk factors. Thus, in addition to socioeconomic factors, such as access to healthcare, this study shows that racial metabolomic differences may underlie the coronary heart disease risk disparity.                                       The last article I want to share is also from our September 16th issue, and it is titled, ADAR1 Prevents Autoinflammatory Processes in The Heart Mediated by IRF7. The first author is Claudia Garcia-Gonzalez, and the corresponding author is Thomas Braun, and they are from Max Planck University.                                       It's essential for a cell to distinguish their own RNA from the RNA of an invading virus to avoid triggering immune responses inappropriately. To that end, each cell makes modifications, and edits its own RNA to mark it as self. One type of edit made to certain RNAs is the conversion of adenosines to inosines. And this is carried out by adenosine deaminase acting on RNA1 or ADAR1 protein. Complete loss of this enzyme causes strong innate immune auto reactivity, and is lethal to mice before birth. Interestingly, the effects of ADAR1 loss in specific tissues is thought to vary. And the effect in heart cells in particular has not been examined.                                     This study, which focused on the heart, discovered that mice lacking ADAR1 activity specifically in cardiomyocytes, exhibit autoinflammatory myocarditis that led to cardiomyopathy. However, the immune reaction was not as potent as in other cells lacking ADAR1. Cardiomyocytes did not exhibit the sort of upsurge in inflammatory cytokines, and apoptotic factors seen in other cells lacking ADAR1. And the animals themselves did not succumb to heart failure until 30 weeks of age. The author suggests that this milder reaction may ensure the heart resists apoptosis, and inflammatory damage because, unlike some other organs, it cannot readily replace cells.   Cindy St. Hilaire:        Today I have with me, Dr Jun Yoshioka, and Dr Yoshinobu Nakayama, and they're from City University of New York. And today we're going to talk about their paper, Interaction of ARRDC4 With GLUT1 Mediates Metabolic Stress in The Ischemic Heart. And this is in our September 2nd issue of Circulation Research. So, thank you both so much for joining me today.   Jun Yoshioka:             Thank you for having us. We are very excited to be here.   Cindy St. Hilaire:        It's a great publication, and also had some really great pictures in it. So, I'm really excited to discuss it. So, this paper really kind of focuses on ischemia, and the remodeling in the heart that happens after an ischemic event. And for anyone who's not familiar, ischemia is a condition where blood flow, and thus oxygen, is restricted to a particular part of the body. And in the heart, this restriction often occurs after myocardial infarctions, also called heart attacks. And so, cardiomyocytes, they require a lot of energy for contraction, and kind of their basic functions. And in response to this lack of oxygen, cardiomyocytes switch their energy production substrate. And so, I'm wondering if before we start talking about your paper, you can just talk about the metabolic switch that happens in a cardiac myocyte in the healthy state versus in the ischemic state.   Jun Yoshioka:             Sure. As you just said, that the heart never stops beating throughout the life. And it's one of the most energy demanding organs in the body. So, under normal conditions, cardiac ATP is mainly derived from fatty acid oxidation, and glucose metabolism contributes a little bit less in adult cardiomyocytes. However, under stress conditions such as ischemia, glucose uptake will become more critical when oxidative metabolism is interrupted by a lack of oxygen. That is because glycolysis is a primary anaerobic source of energy. We believe this metabolic adaptation is essential to preserve high energy phosphates and protect cardiomyocytes from lethal injuries. The concept of shifting the energy type of stress preference toward glucose, as you just said, has been actually long proposed as an effective therapy against MI. For example, GIK glucose insulin petition is classic.                                       Now, let me explain how glucose uptake is regulated. Glucose uptake is facilitated by multiple isophones of glucose transporters in cardiomyocytes. Mainly group one and group four, and the minor, with a minor contribution of more recently characterized STLT1. In this study, we were particularly interested in group one because group one is a basal glucose transporter.                                       Dr Ronglih Liao, and Dr Rong Tian's groups reported nearly two decades ago that the cardiac over-expression of group one prevents development of heart failure, and ischemic damage in mice. Since they are remarkable discoveries, the precise mechanism has not yet been investigated enough, at least to me. Especially how acute ischemic stress regulates group one function in cardiomyocytes. We felt that this mechanism is important because there is a potential to identify new strategies around group one, to reduce myocardiac ischemic damage. That is why we started this project hoping to review a new mechanism by which a protein family, called alpha-arrestins, controls cardiac metabolism under both normal, and diseased conditions.   Cindy St. Hilaire:        That is a perfect segue for my next question, actually, which is, you were focusing on this arrestin-fold protein, arrestin domain-containing protein four or ARRDC4. So, what is this family of proteins? What are arrestin-fold proteins? And before your study, what was known about a ARCCD4, and its relationship to metabolism, and I guess specifically cardiomyocyte metabolism?   Jun Yoshioka:             So, the arrestin mediated regulation of steroid signaling is actually common in cardiomyocytes. Especially beta, not the alpha, beta-arrestins have been well characterized as an adapter protein for beta-adrenergic receptors. Beta-arrestins combine to activate beta-adrenergic receptors on the plasma membrane, promote their endosomal recycling, and cause desensitization of beta-adrenergic signaling. Over the past decade, however, this family, the arrestin family, has been extended to include a new class of alpha-arrestins. But unlike beta-arrestins, the physiological functions of alpha-arrestins remain largely unclear based in mammalian cells. Humans, and mice have six members of alpha-arrestins including Txnip, thioredoxin interacting protein called Txnip, and five others named alpha domain-containing protein ARRDC1 2, 3, 4 and 5. Among them Txnip is the best studied alpha-arrestin. And Txnip is pretty much the only one shown to play a role in cardiac physiology.                                       Txnip was initially thought to connect alternative stress and metabolism. However, it is now known that the Txnip serves as an adapter protein for the endocytosis of group one, and group four to mediate acute suppression of glucose influx to cells. In fact, our group has previously shown that the Txnip knockout mice have an enhanced glucose uptake into the peripheral tissues, as well as into the heart. Now, in this study, our leading player is ARRDC4. The arrestin-domains of ARRDC4 have 42% amino acid sequence similarities to Txnip. This means that the structurally speaking ARRDC4 is a brother to Txnip. So, usually the functions of arrestins are expected to be related to their conserved arrestin-domains. So, we were wondering whether two brothers, Txnip, and ARRDC4, may share the same ability to inhibit the glucose transport. That was a starting point where we initiated this project.   Cindy St. Hilaire:        That's great. And so, this link between ARRDC4, and the cardiac expression of gluten one and gluten four, I guess, mostly gluten one related to your paper, that really wasn't known. You went about this question kind of based on protein homology. Is that correct?   Jun Yoshioka:             That is right.   Cindy St. Hilaire:        And so, ARRDC4 can modulate glucose levels in the cell by binding, and if I understand it right, kind of helping that internalization process of glute one. Which makes sense. You know, when you have glucose come into the cell, you don't want too much. So, the kind of endogenous mechanism is to shut it off, and this ARRDC4 helps do that. But you also found that this adapter protein impacts cellular stress, and the cellular stress response. So, I was wondering if you could share a little bit more about that because I thought that was quite interesting. It's not just the metabolic impact of regulating glucose. There's also this cellular stress response.   Jun Yoshioka:             Right? So, Txnip is known to induce oxidative stress. But about the ARRDC4, we found that ARRDC4 actually does not induce oxidative stress. Instead, we found that it reproducibly causes ER, stress rather than oxidative stress. So, let Yoshinobu talk about the ER stress part. Yoshinobu, can you talk about how you found the ER stress story?   Yoshinobu Nakayama: So, then let's talk about the, yeah, ER stress caused by ARRDC4. The ER stress caused by ARRDC4, year one was the biggest challenge in this study, because it's a little bit difficult to how we found a link of the glucose metabolism to the effect of the ARRDC4, only our stress. And at the other point of the project, we noticed that a ARRDC4 causes ER stress reproducibly, but we did not know how. So, both group one, and ARRDC4 are membrane proteins mainly localized near the plasma membrane. Then how does ARRDC4 regulate the biological process inside in the plasma radical? So, we then hypothesize that ARRDC4 induces intercellular glucose depravation by blocking cellular glucose uptake, and then interferes with protein glycosylation, thereby disturbing the ER apparatus. That makes sense because inhibition of group one trafficking by ARRDC4 was involved in the unfolded protein response in ischemic cardiomyocytes.   Cindy St. Hilaire:        So how difficult was that to figure out? How long did that take you?   Yoshinobu Nakayama: How long? Yeah. Is this the question?   Cindy St. Hilaire:        It's always a hard question.   Yoshinobu Nakayama: I think it's not several weeks. Maybe the monthly, months project. Yeah.   Cindy St. Hilaire:        Okay. It's always fun when, you know, you're focusing on one angle, and then all of a sudden you realize, oh, there's this whole other thing going on. So, I thought it was a really elegant tie-in between the metabolism, but also just the cellular stress levels. It was really nice.                                       So, you created a full body knockout of ARRDC4 in the mouse, and you did all the proper kind of phenotyping. And at baseline everything's normal, except there's a little bit of changes in the blood glucose levels. But I also noticed when you looked at the expression of ARRDC4 in different tissues, it was very high in the lungs, and also in the intestines. And so, I know your study didn't focus on those tissues, but I was wondering if you could possibly speculate what ARRDC4 is doing in those tissues? Is it something similar? Do those cells under stress have any particular metabolic switching that's similar?   Jun Yoshioka:             Well, actually we don't have any complete answer for that question, because like you said, we didn't focus on lung, and other tissues. But I could say that actually the brother of ARRDC4, Txnip, is also highly expressed in lung, and bronchus, and in those organs. So, it's interesting because, which means that, the molecule is very oxygen sensitive, I will say. Both brothers. But that's all we know for now. But that's a very great point. And then we are excited to, you know.   Cindy St. Hilaire.        Yeah.   Jun Yoshioka:             Move on to the other tissues.   Cindy St. Hilaire:        I was thinking about it just because I've actually recently reviewed some papers on pulmonary hypertension. So, when I saw that expression, that was the first thing I thought of was, oh, they should put these mice in a sugen/hypoxia model, and see what happens.   Jun Yoshioka:             Right?   Cindy St. Hilaire:        So, there's an idea for you, Yoshinobu. A K-99 grant or something. And also, because it's a full body knockout, even when you're looking at the heart, obviously the cardiomyocytes are really the most metabolically active cell, but cardiac fibroblasts are also a major component of the heart tissue. And so, do you know, is the, I guess, effects or the protectiveness of the ARRDC4 knockout heart, is it mostly because of the role in the cardiomyocytes or is there a role for it also in the fibroblast?   Yoshinobu Nakayama: Yeah, that's a very great question. Yeah. So, although we use the systemic knockout mice in the study, we believe that the beneficial effect of ARRDC4 deficiency is cardiac, autonomous. But this is because cardioprotection was demonstrated in the isolated heart experiments. But, you know, root is still uniformly expressing all cell types within the heart.                                       To address this, we have tested the specific effects of ARRDC4 on cardiac fibroblasts, and inflammatory cells. ARRDC4 knockout hearts had a twofold increase in myocardial glucose uptake over wild-type hearts during insulin-free perfusion. However, an increase in glucose uptake in isolated cardiac fibroblast or inflammatory cells was relatively mild, with about 1.2 fold increase over wild-type cells.                                       Thus we conclude that cardiomyocytes are the measure contributed to the cardiac metabolic shift. And then the mechanism within cardiomyocytes should play the major role in cardioprotection.   Jun Yoshioka:             I might, at one point, because, you know, the fibroblasts, they don't need to beat, right?   Cindy St. Hilaire:        Right.   Jun Yoshioka:             The inflammasome cells. They don't need to beat neither. So, they don't need that much energy. So, the cardiomyocytes energy metabolism is very important. So, that's why this mechanism is kind of more important in cardiomyocytes than other cell types.   Cindy St. Hilaire:        Yeah. And I think, you know, your phenotyping of the mice at baseline show that there's really no effect in a cell that's not under stress. So, it's really, really nice finding. Yeah.                                       This article, I should say, is featured on the cover of the September 2nd Circulation Research issue. And it's got this really nice 3D modeling of the binding of ARRDC4 to glute one. And I was reading the paper, and the methods said, you use some AI for that. So, I'm sure other people have heard, too, AI in protein modeling is important. But AI in art, right? There's that new DALL-E 2 program. So how are you able to do this? How did that work?   Jun Yoshioka:             So, our study used is called AlphaFold, which applies the artificial intelligence-based deep learning method. AlphaFold, nowadays, everybody really is interested in AlphaFold. AlphaFold uses structural, and genetic data to come up with a model of what the protein of interest should look like. So, that is also how we got the protein structure, ARRDC4. We think that the ability of AlphaFold to precisely predict the protein structure from amino acid sequence would be a huge benefit to life sciences, including of course, cardiovascular science research, because of high cost, and technical difficulties in experimental methods.                                       It's very useful if you can computationally predict the complex from individual structures of ARRDC4. And group one, which is actually structure of group one, is available in a protein data bank. But ARRDC4, it was not available. That's why we used AlphaFold.                                       And then we use the docking algorithm called Hdoc. So, based on these AI analysis, we could successfully identify specific residues in a C terminal arrestin domain as an international interface, that regulates group one function. So, we believe this AI method will pretty much accelerate efforts to understand the protein, protein interactions. And we believe that will enable more advanced drug discovery, for example, in very near future.   Cindy St. Hilaire:        Yeah, it's really great. I started thinking about it in terms of some of the things I'm studying. So yeah, it was really nice. Jun Yoshioka:             Try next time.   Cindy St. Hilaire:        Yeah, I will, I will. Actually, I went to the website, and was playing with it before I got on the call with you. So, how do you think your findings can be leveraged towards informing clinical decision making or even developing therapeutics?   Jun Yoshioka:             So, let me talk about what needs to be done. There are more things we must do.   Cindy St. Hilaire:        Always. Yeah.   Jun Yoshioka:             One of the most clinically relevant questions is whether ARRDC4 inhibition actually can mitigate development of post MI heart failure, and reduce mortality in the chronic phase, not the acute phase. Because in this paper we just did the seven day post MI, which is kind of like acute to subacute phase. But you never know what's going to happen in the chronic phase, right? And that is actually not so simple to answer because there are so many issues that you should consider. For example, Dr E. Dale Abel's lab has reported previously that cardiomyacites, specific group one, knockout in mice does not really accelerate the transition from compensated hypotrophy to heart failure. Also, the same group has shown that the overexpression group one does not actually prevent LV dysfunction in the mouse model of pressure overload. So, it is possible that ARRDC knockout can be, do much, or even harmful to LV remodeling in a chronic phase because chronic phase, it's not, it's getting hypoxy conditions, right?   Cindy St. Hilaire:        Yeah. So, it really might be something, I guess, personalized medicine is not the phrase I'm looking for. But I guess temporarily modulated, it would be something maybe we can figure out in an acute phase versus.   Jun Yoshioka:             Chronic phase.   Cindy St. Hilaire:        Yeah. Yeah.   Jun Yoshioka:             This makes sense. Because, you know, high capacity of ATP synthesis, by oxidating metabolism, could be important for chronic heart failure. So, it's selecting substrates. Energy substrates is no longer, you know, that issue. So, I'm not sure I'm answering your question, but this is the point that we consider to move on to the next.   Cindy St. Hilaire:        Well, that's great. And I think that was my next question, really. What is next? Are you really going to try to pinpoint where you could possibly target?   Jun Yoshioka:             Right. So, the first point we have to figure out about chronic phase, and another point we are interested in, is what's going on at the level of mitochondria. Does ARRDC4 knockout hearts have a different activity of electron transport chain or glycolytic enzymes within mitochondria?   Cindy St. Hilaire:        Or even mitochondrial fission infusion because it's, you know, it's a machinery.   Jun Yoshioka:             Yeah. And how about the other essential pathways in glucose metabolism such as mTOR, AMPK and HEF1, and so on. So, all these must be determined to help understand the more precise role of ARRDC4 in cardiac metabolism, we believe. Cindy St. Hilaire:        It's a wonderful study, and now we have even more questions to ask using your great model. Congratulations again.   Yoshinobu Nakayama: Thank you so much.   Cindy St. Hilaire:        Dr Yoshioka, and Dr Nakayama.   Jun Yoshioka:             Thank you.   Cindy St. Hilaire:        A wonderful paper, and congrats on getting the cover, and thank you so much for joining me today.   Jun Yoshioka:             Thanks well so much for having us.   Yoshinobu Nakayama: Thank you.   Cindy St. Hilaire:        That's it for the highlights from our September 2nd, and our September 16th issues of Circulation Research. Thank you so much for listening. Please check out our CircRes Facebook page, and follow us on Twitter, and Instagram with the handle @circres, and hashtag discovercircres. Thank you to our guests, Dr Jun Yoshioka, and Dr Yoshinobu Nakayama.                                     This podcast is produced by Ishara Ratnayaka, edited by Melissa Stonerm, and supported by the editorial team of Circulation Research. Some of the copy text for highlighted articles is provided by Ruth Williams. I'm your host, Dr Cindy St. Hilaire, and this is Discover CircRes, your on the go source for the most exciting discoveries in basic cardiovascular research.                                       This program is copyright of the American Heart Association 2022. The opinions expressed by speakers in this podcast are their own, and not necessarily those of the editors or of the American Heart Association. For more information, please visit ahajournals.org.

This week on “The Learning Curve,” Cara Candal and Gerard Robinson talk with Dr. Bill Evers and Ze’ev Wurman, of the Independent Institute, about the challenges of ensuring all students have access to quality K-12 math and science education in California and across the U.S. They review the findings of the 1983 report, A Nation At Risk, and international TIMSS and PISA data going back a decade... Source

Tommaso Gazzolo"Festival Filosofia"https://www.festivalfilosofia.it/Festival Filosofia, CarpiVenerdì 16 settembre 2022, ore 11:30La lezione dei classici con Tommaso GazzoloChe cos'è la dottrina pura del diritto?di Hans KelsenQuale ruolo ha avuto l'opera di Kelsen nell'elaborazione della dottrina del positivismo giuridico, anche in relazione a possibili esiti nichilistici?Tommaso Gazzolo insegna Filosofia del diritto presso il Dipartimento di Giurisprudenza dell'Università degli Studi di Sassari. Si occupa di ricezione e filosofia dell'Illuminismo, storia della filosofia del diritto, filosofia ed etica. Tra le sue opere recenti: Scetticismo e autorità. La filosofia del diritto di Giuseppe Rensi (1912-1922) (Roma 2012); La scrittura della legge. Saggio su Montesquieu (Napoli 2014); Essere/Dover-essere. Saggio su Hans Kelsen (Milano 2016); Il caso giuridico. Una ricostruzione giusfilosofica (Torino 2018); Una doppia appartenenza. Tullio Ascarelli e la legge come interpretazione (Pisa 2019); Che cos'è la dottrina pura del diritto? Di Hans Kelsen (a cura di, Milano 2022)."Che cos'è la dottrina pura del diritto?"A cura di Tommaso GazzoloLa nave di Teseohttp://www.lanavediteseo.eu/“Che cos'è la ‘dottrina pura del diritto', il nome sotto il quale Hans Kelsen ha pensato la propria filosofia giuridica? A questa domanda prova a rispondere il testo qui presentato per la prima volta al lettore in traduzione italiana. Come la stessa forma interrogativa del titolo mostra, il tentativo da parte di Kelsen di fornire una ‘sintesi', una sistemazione definitiva dei principi fondamentali della sua teoria, non è separabile dalla critica continua della medesima, dalla sua costante messa in questione. Dire che cosa sia la dottrina pura, per il suo autore, significa sempre ed anche continuare ad interrogarla, esattamente come avviene in queste pagine che costituiscono una delle testimonianze più chiare di tale movimento interno al suo pensiero. Questo libro è una introduzione ed un invito a conoscere i lineamenti essenziali della dottrina pura di Kelsen e, al contempo, un testo che forse meglio di qualsiasi altro fa luce sulla continua ‘crisi' della sua filosofia del diritto.”Dall'introduzione di Tommaso Gazzolo“La collana si muove tra diritto e filosofia, interrogandosi sulla crisi di vecchi istituti, che, nel loro declinare, assumono diversa fisionomia o generano nuove forme. La crisi suggerisce ricognizione del passato e sguardo verso il domani. Insieme, depone e impone.”Massimo Cacciari e Natalino IrtiIL POSTO DELLE PAROLEAscoltare fa Pensarehttps://ilpostodelleparole.it/

Simone Bartesaghi is an Italian award-winning filmmaker who has been recognized by the Directors Guild of America (DGA) and AMPTP (Alliance of Motion Picture and Television Producer) as an artist with "Extraordinary Ability in Directing”.At the age of 24 Simone received his Master's Degree in Economics at the University of Pisa, Italy. Three years later he established a successful Consulting Company specializing in Corporate Organization and Planning. In 2001 he gave up his thriving career to pursue his childhood dream.Two years later he won several prizes as the Writer/Director of short films, but the highest recognition came when he won the first and second place at the Milan International Film Festival, and became the recipient of both the Top and second Award, TWO Scholarships for THE LOS ANGELES FILM SCHOOL.Only four years after his arrival in the United States, he directed his first feature film DOWNSTREAM, that acquired a theatrical release and also received the prestigious Accolade Award.Simone's second feature RUN, a 3D film that he wrote and directed, has won several prizes including Best Screenplay and Best Emerging Director and is distributed in USA by Millennium. The movie is about the new discipline Parkour (Freerunning) with a rich cast including Eric Roberts (The Dark Knight), Adrian Pasdar (Heroes), Kelsey Chow (Pair of Kings) and William Moseley (Chronicles of Narnia).Simone's accomplishments and communicative skills have been recognized by many educational organization around the world and he is now an Adjunct Professor in Filmmaking at the prestigious Santa Monica College.Simone is also a published author with his book "The Director's Six Senses", an innovative, unique, and engaging approach to the development of the skills that every visual storyteller must have. The Director's Six Senses is an innovative, unique, and engaging approach to the development of the skills that every visual storyteller must have. It's based on the premise that a director is a storyteller 24/7 and must be aware of the “truth” that he or she experiences in life in order to be able to reproduce it on the big screen. Through a series of hands-on exercises and practical experiences, the reader develops the “directorial senses” in order to be able to tell a story in the most effective way.Enjoy my conversation with Simone Bartesaghi.

La Scuola Superiore Sant'Anna di Pisa organizza un corso di Biologia spaziale con l'obiettivo di formare professionisti nel campo della ricerca biologica e biomedica a supporto dell'esplorazione umana nello spazio. Nei prossimi anni saranno necessarie competenze molto specifiche per garantire la sicurezza degli astronauti nei viaggi spaziali sempre più lunghi. Costruire muscoli artificiali con una stampante 3D, questo è il risultato ottenuto dal laboratorio di 'Robotica bioispirata' dell'Istituto Italiano di Tecnologia Corrado De Pascali, primo autore dello studio e ricercatore di IIT, ci racconta quali siano le possibili applicazioni, tra le altre anche lo sviluppo di una proboscide artificiale.

In this episode we hear that Jason's tree-less-tree-house has become the leaning tower of Pisa, KJ isn't too bubbly about his latest encounter with Scuff X and Nick has increased a girl's chances for getting glaucoma by 20%. Be sure to hit up or sponsor Bits & Bits at www.bitsbits.com and use coupon code: MORSELS15 to save 15% Support us on Patreon: www.patreon.com/shopsoundspodcast You can find the three of us on Instagram, Youtube and Tiktok : @bourbonmoth @kjsawdust @keywoodworks --- Send in a voice message: https://anchor.fm/shopsoundspodcast/message

Das Wichtigste für Sie an diesem Freitag: Die Welt trauert um Königin Elisabeth II., die EU-Energieminister beraten über Wege aus der Krise, die CDU sucht ihre Rolle und die US Open gehen ins Finale.

Giuseppe Cambiano"Festival Filosofia"https://www.festivalfilosofia.it/Festival Filosofia, ModenaVenerdì 16 settembre 2022, ore 10:00la lezione dei classici con Giuseppe Cambiano"Repubblica" di PlatoneAttraverso un'analisi del testo di Platone e del contesto-storico di appartenenza, si approfondisce la nozione di giustizia, tra virtù, conoscenza, tecnica ed esercizio del potere.Giuseppe Cambiano è professore emerito di Storia della filosofia antica presso la Scuola Normale Superiore di Pisa. A partire da una rigorosa analisi storico-filosofica sui classici della filosofia greca, intorno ai temi delle scienze e delle tecniche, ha studiato la fortuna della polis, dei classici (Aristotele, Tucidide, Senofonte, Plutarco) e delle categorie del pensiero politico greco (repubblica, democrazia, libertà, giustizia) nella cultura europea moderna e contemporanea. Tra le sue opere recenti: I filosofi in Grecia e a Roma. Quando pensare era un modo di vivere (Bologna 2013); Come nave in Tempesta. Il governo della città in Platone e Aristotele (Roma-Bari 2016); Filosofia italiana e pensiero antico (Pisa 2016); I moderni e la politica degli antichi. Tra Machiavelli e Nietzsche (Bologna 2018); Sette ragioni per amare la filosofia (Bologna 2019); La scienza e l'irrazionale. Immagini storiografiche della Grecia antica (Pisa 2021); Filosofia greca e identità dell'Occidente. Le avventure di una tradizione (Bologna 2022).Giuseppe Cambiano"Filosofia greca e identità dell'Occidente"Le avventure di una tradizionehttps://www.mulino.it/«Atene libera fu la madre delle scienze e dell'arti della più colta umanità e vi cominciarono i filosofi da Solone, principe de' sette sappienti di Grecia, che ordinò la libertà ateniese con le sue leggi e lasciò quel motto, pieno di tanta civile utilità: Gnothi seauton, “Nosce te ipsum”, che fu scritto sugli architravi de' templi, proposto come una vera divinità».Giambattista VicoPer caratterizzare l'identità dell'Occidente si è soliti chiamare in causa tradizioni diverse: la democrazia greca, il diritto romano, il cristianesimo, la rivoluzione scientifica e così via. A volte si evocano anche la filosofia e la scienza greca, un'idea caratteristica non soltanto di filosofi come Husserl, Heidegger o Popper, ma anche di scrittori come Jorge Luis Borges. Studioso da sempre attento al tema dell'incontro e del contatto fra culture, l'autore scruta oltre duemila anni di storia del pensiero per mettere in dubbio che la Grecia sia sempre stata considerata terra di origine della filosofia e che quest'ultima sia una sua esclusività, fatta poi propria dall'Europa e dall'Occidente come segno identitario. Si tratta piuttosto di una costruzione storica, dell'«invenzione di una tradizione». L'identità europea è infatti l'esito di una vicenda complessa, è un'identità plurima in continuo movimento, tutt'altro che monolitica e uniforme. E forse proprio questa è la sua peculiarità, forse anche il suo pregio.IL POSTO DELLE PAROLEAscoltare fa Pensarehttps://ilpostodelleparole.it/

Prof. Pezzini's handout can be found here: tinyurl.com/nkxw4saa This lecture was given on May 9, 2022 at Oxford University. For information on upcoming events, please visit our website at www.thomisticinstitute.org. About the speaker: Giuseppe Pezzini is Associate Professor of Latin Language & Literature at Corpus Christi College, Oxford. Prof. Pezzini returned to CCC in 2021, after five beautiful years of teaching in St Andrews (2016–2021), and research fellowships at Magdalen College Oxford (2013–2015) and the Institute for Advanced Study in Princeton (2016). He has studied and worked in excellent collegiate institutions, the Scuola Normale Superiore in Pisa (2003–2008) and the University of Oxford (D.Phil. 2012). From 2010 to 2013, he worked as Assistant Editor for the Oxford Dictionary of Medieval Latin. He was visiting professor at the University of Turin in 2020, visiting fellow at Leiden University in 2015, and visiting student at CCC itself, back in 2006, where everything began. He is currently supervising research projects on the Comoedia Togata and the Theory of Fiction in late Antique commentaries.

Apologies for the gaps in new episode this summer. Even though we had pre-recorded, vacations and some technical difficulties (my computer lost the ability to charge last week) caused us to miss our regular Wednesday drops. We should be back on track going forward and you should get at least an episode a week dropped in this feed every Wednesday morning. We appreciate your patience.In this episode:Mike and Ed discuss the Avengers' statement to the Daily Standard that the recent tremors felt around the world were created by the Mole Man attempting to speed up the planet's rotation to destroy all life on the surface. Thank goodness for the Avengers, but how confident are we that villains such as the Mole Man will stop trying to wipe out humanity with new and creative ways? When villains have the ambition to destroy the planet and the technological means to do so, what should we as a society do to prepare? We don't have all the answers, but we suggest you go and see the leaning Tower of Pisa before someone knocks it over for good… Behind the issue:We believe this is the first mention of the “Daily Standard”. Stan usually used the Daily Bugle whenever he needed a paper mentioned, but for some reason he made up a new paper in this issue for the Avengers to provide the exclusive.In this issue:Giant-Man is alerted by his ants to the fact that the Mole Man is up to something. He tries to engage the Avengers on this potential plot by the Mole Man, and to have them investigate, but they brush him off. And so he investigates on his own, going underground and being captured by the Mole Man and his followers. And then Mole Man's plan is revealed - he is speeding up the Earth's rotation, and people around the world start to feel it. The Avengers feel badly for blowing off Giant-Man, and they go to rescue him. A furious battle ensues underground, although the Mole Man and his crew escape. The Mole Man teams up with another Fantastic Four antagonist, the Red Ghost, and they battle the Avengers together. The Avengers ultimately defeat the terrible twosome and their followers, and stop the Earth from seeing up its rotation, and their heroism is reported in the Daily Standard.Assumed before the next episode:People are dealing with the fallout of the Earth briefly speeding up its rotation, which caused untold devastation and potentially longterm problems.This episode takes place:After the Daily Standard has reported this adventure on its front pages. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.superserious616.com

With Alessia Gimelli, Fondazione Toscana Gabriele Monasterio, Pisa - Italy & Riccardo Liga, University of Pisa, Pisa - Italy Link to paper Link to editorial

Škola namiesto toho, aby podnecovala kreativitu, kritické myslenie a úprimný záujem o rôzne oblasti života, tak to potláča aby tak z ľudí spravila robotov, ktorí mechanicky vypĺňajú vzorce. U študentov to vyvoláva obrovskú mieru frustrácie, tvrdí čerstvá maturantka a naša najlepšia rečníčka Tereza Okálová zo Slovenskej debatnej asociácie. „Naša mládež miluje prepych. Nemá správne správanie. Neuznáva autority a nemá úctu pred starobou. Deti odvrávajú rodičom, srkajú pri jedle a tyranizuju svojich učiteľov.“ Tento povzdych nad skazenosťou mládeže má už vyše 2000 rokov a pripisuje sa gréckemu filozofovi Sokratovi. Takéto vzdychanie nad údajne upadajúcimi mravmi a vzdelanosťou mladých však Sokrata prežilo a trvá až dodnes. Za pravdu by im mohli dať i zhoršujúce sa výsledky v PISA testoch či rastúci podiel takzvaných funkčných analfabetov. Pravdou ale je aj to, že mnohí mladí to majú v hlave veľmi dobre usporiadané a rozhodne nám žiadnu hanbu nerobia. Medzi takýchto mladých patrí aj čerstvá maturantka a najlepšia slovenská debatérka Tereza Okálová. Ako vyzerajú debaty podľa pravidiel logiky, faktov a vecných argumentov? A ako sa ona pozerá na našu spoločnosť a úroveň našich verejných či politických diskusii? No a aký je jej názor na náš vzdelávací systém? Počúvate Ráno Nahlas, pekný deň a pokoj v duši praje Braňo Dobšinský    

Škola namiesto toho, aby podnecovala kreativitu, kritické myslenie a úprimný záujem o rôzne oblasti života, tak to potláča aby tak z ľudí spravila robotov, ktorí mechanicky vypĺňajú vzorce. U študentov to vyvoláva obrovskú mieru frustrácie, tvrdí čerstvá maturantka a naša najlepšia rečníčka Tereza Okálová zo Slovenskej debatnej asociácie. „Naša mládež miluje prepych. Nemá správne správanie. Neuznáva autority a nemá úctu pred starobou. Deti odvrávajú rodičom, srkajú pri jedle a tyranizuju svojich učiteľov.“ Tento povzdych nad skazenosťou mládeže má už vyše 2000 rokov a pripisuje sa gréckemu filozofovi Sokratovi. Takéto vzdychanie nad údajne upadajúcimi mravmi a vzdelanosťou mladých však Sokrata prežilo a trvá až dodnes. Za pravdu by im mohli dať i zhoršujúce sa výsledky v PISA testoch či rastúci podiel takzvaných funkčných analfabetov. Pravdou ale je aj to, že mnohí mladí to majú v hlave veľmi dobre usporiadané a rozhodne nám žiadnu hanbu nerobia. Medzi takýchto mladých patrí aj čerstvá maturantka a najlepšia slovenská debatérka Tereza Okálová. Ako vyzerajú debaty podľa pravidiel logiky, faktov a vecných argumentov? A ako sa ona pozerá na našu spoločnosť a úroveň našich verejných či politických diskusii? No a aký je jej názor na náš vzdelávací systém? Počúvate Ráno Nahlas, pekný deň a pokoj v duši praje Braňo Dobšinský    

In this episode of the TGU podcast Frank sits down for a chat with Ashwin Ballal who has authored the book on Diego Simeone, 'Made in Argentina, Mastered in Madrid' out now via Pitch Publishing. Frank and Ashwin discuss Simeone's playing career including his early days at Pisa, his subsequent move to Spain with Atlético Madrid and time in Italy with Inter Milan and Lazio. Ashwin talks about the beginnings of Simeone's management career with Catania, the influence Italy has had on his managerial traits and characteristics, and the evolution of the Argentinean's management style on and off the field. Enjoy the conversation. You can find Ashwin on Twitter at @ashwinballal_. You can find Frank on Twitter at @SerieA_Aust. You can find The Gentleman Ultra on Twitter @GentlemanUltra. Please don't forget to rate, review and share the podcast and thanks for listening. Enjoy your Calcio!

Nicola Terrenato"La grande trattativa"L'espansione di Roma in Italia tra storia e archeologiaCarocci Editorehttp://www.carocci.itE se la conquista romana dell'Italia non fosse stata solo un'operazione militare? Il volume propone una nuova interpretazione del processo che portò all'unificazione della penisola nel IV e III secolo a.C. Basandosi su di un'ampia rassegna delle fonti storiche, ma soprattutto del materiale epigrafico e archeologico più recente, l'autore ricostruisce un quadro complesso ed eterogeneo di connessioni che legavano fra loro famiglie romane e italiche, attraversando l'Italia intera. Il ruolo della diplomazia e della contrattazione vi appare almeno equivalente a quello della minaccia bellica. Da una parte e dall'altra, vi furono probabilmente casate nobili che si allearono per costituire una nuova entità politica in un contesto mediterraneo globale che per la prima volta favoriva l'emergere di imperi con ampi territori. Premiata dall'Archaeological Institute of America con il Wiseman Book Award per il 2021, l'edizione originale in lingua inglese di questo libro ha scatenato accesi dibattiti fra storici e archeologi.Nicola Terrenato è E. B. Van Deman Collegiate Professor of Roman Studies nella University of Michigan, dove dirige anche il Kelsey Museum of Archaeology. Formato in Archeologia romana alla Sapienza Università Roma e all'Università di Pisa, ha insegnato alla University of North Carolina. Ha condotto scavi e ricognizioni in vari siti a Roma, Volterra, Donoratico e in Val di Cecina. Dirige il Gabii Project, un progetto di archeologia urbana all'avanguardia nella documentazione e pubblicazione digitale e in 3D. Si occupa di imperialismo, formazione dello Stato, società rurale, storia dell'archeologia e geoarcheologia.IL POSTO DELLE PAROLEAscoltare fa Pensarehttps://ilpostodelleparole.it/

Since when we started this podcast, we've been repeating that, here in Tuscany, if you keep your eyes open and look beyond the picture-perfect postcard image, you can find all sorts of hidden treasures. Sometimes it just takes a bit of luck and a whole lot of determination. A walk down the high street of a random town can mean that you bump into a weird logo and fall precipitously into a veritable rabbit hole. For a pop-up art exhibition spot, the city government of Cascina, near Pisa, has chosen a weird logo, a stylized fish that wears a crown. Not many know that this is actually an ancient Christian symbol, dating back to the origins of Christianity. Even less people know that the crowned fishes are an integral part of a fresco that covers one of the walls of the little church of Saint Jacob's, in the hamlet of Zambra. What makes this fresco special? Well, it's 12 centuries old and it's the only one of its kind in Italy. Follow us for this very particular episode, where we will walk you through the treasure hunt that led us to uncover the mystery of the crowned fishes and discover how this unassuming little church in the middle of nowhere is one of Tuscany's best kept secrets. You only need a bit of patience - and a valid library card. Do you like the episodes dedicated to the least known corners of our region? Let us know by commenting here or sending us an email: we'll be more than happy to answer. It'd be swell if you also followed us on your favourite podcasting app, so that you don't miss a single episode. Remember, we have a world of stories to tell you!Email: podcast@larno.itFacebook: https://www.facebook.com/larno.itTwitter: @arno_it / @WhatsupTuscanyBACKGROUND MUSICPipe Choir - Bom Bom Breakthrough (Instrumental)Aerocity - Love LostCityfires - Blood Problems (Instrumental)Wayne John Bradley - SummercyclePipe Choir - Almost Time (Instrumental)Wayne John Bradley - Blues Rock Original InstrumentalAll released under Creative Commons Attribution 4.0 International Licensehttps://soundcloud.com/pipe-choir-2/pipe-choir-bom-bom-breakthrough-creative-commons-instrumentalhttps://soundcloud.com/argofox/aerocity-love-losthttps://soundcloud.com/ljayofficial/blood-problems-instrumentalby-cityfireshttps://soundcloud.com/ayneohnradley/summercycle-original-indie-style-instrumental-creative-commonshttps://soundcloud.com/pipe-choir-2/pipe-choir-almost-time-instrumental-creative-commonshttps://soundcloud.com/ayneohnradley/blues-rock-original-instrumentalcreative-commonshttp://www.pipechoir.com/

Ciao Italiani Veri, rieccoci in compagnia di Davide. Vi è piaciuto il primo episodio? Il secondo è altrettanto affascinante. Davide ci invita ad affrontare il cammino con il giusto allenamento fisico, ma anche con la giusta predisposizione mentale, che non può prescindere dalla consapevolezza della necessaria fatica. Meglio quindi viaggiare leggeri, portando solo l'essenziale. Pronti a partire, amici?

5/5. Dernier épisode de la série sur les systèmes scolaires les mieux classés au Pisa. Pour « La Story », le podcast d'actualité des « Echos », Michèle Warnet et son invitée Virginie Robert exposent le cas d'école de la Finlande qui fait figure de bon élève dans le monde et d'exemple en Europe.La Story est un podcast des « Echos » présenté par Michèle Warnet. Cet épisode a été enregistré en août 2022. Rédaction en chef : Clémence Lemaistre. Invitée : Virginie Robert (cheffe du service Monde aux « Echos »). Réalisation : Nicolas Jean. Musique : Théo Boulenger. Identité graphique : Upian. Photo : Reuters. Sons : Annie Philippe « Les enfants de Finlande » (1968), « Finlande : l'école, un paradis pour les enfants ? » et « Le système éducatif en Finlande, cet OVNI » France 2. Notre politique de confidentialité GDPR a été mise à jour le 8 août 2022. Visitez acast.com/privacy pour plus d'informations.

Quatrième épisode de la série sur les systèmes scolaires les mieux classés au Pisa. Pour « La Story », le podcast d'actualité des « Echos », Michèle Warnet et son invité Gabriel Nedelec reviennent sur la remontée spectaculaire des résultats en Pologne que la chute guette maintenant en raison de politiques rétrogrades.La Story est un podcast des « Echos » présenté par Michèle Warnet. Cet épisode a été enregistré en août 2022. Rédaction en chef : Clémence Lemaistre. Invité : Gabriel Nedelec (journaliste aux « Echos »). Réalisation : Nicolas Jean. Musique : Théo Boulenger. Identité graphique : Upian. Photo : MIGUEL MEDINA/AFP. Sons : Hey « Moja i twoja nadzieja », France 2, Bruno Maltor, Euronews. Notre politique de confidentialité GDPR a été mise à jour le 8 août 2022. Visitez acast.com/privacy pour plus d'informations.

Troisième épisode de la série sur les systèmes scolaires les mieux classés au Pisa. Pour « La Story », le podcast d'actualité des « Echos », Michèle Warnet et son invité Yann Rousseau explorent la réalité pas si rose pour les écoliers singapouriens d'être numéro deux du classement mondial pour les acquis des élèves.La Story est un podcast des « Echos » présenté par Michèle Warnet. Cet épisode a été enregistré en juillet 2022. Rédaction en chef : Clémence Lemaistre. Invité : Yann Rousseau (correspondant des « Echos » à Tokyo). Réalisation : Nicolas Jean. Musique : Théo Boulenger. Identité graphique : Upian. Photo : 2020 ZDL/Shutterstock. Sons : Suthasini « Nam Singapore », MOE Singapore, Euronews, Monde des Titounis, France 2. Notre politique de confidentialité GDPR a été mise à jour le 8 août 2022. Visitez acast.com/privacy pour plus d'informations.

Superman is a sidekick in this Richard Pryor comedy. Like podcasts try In The Wild https://apple.co/3TcCkICStream Orphan: First Kill https://bit.ly/3R4a1u3 now on Paramount+. Try it FREE!See Top Gun: Maverick in theaters and now bring it home on Digital. Tom Cruise stars in the spectacular, action-packed epic, which critics are calling "one of the greatest movies ever made". Buy Top Gun: Maverick on Digital now and dive into over 110 minutes of incredible behind-the-scenes bonus content! Available at participating retailers. Rated PG-13. From Paramount Pictures.Exploring why Superman 3 is secretly a great movie: Richard Pryor's scene eating performance and his love for Superman movies, Superman drinks, and Superman fights Superman. A brief history of why birthdays suck from Egypt to Rome to Greece and To Uncle Steve's BBQ. Dave gets sentimental over the leaning tower of pizza gag from The Goofy Movie as it relates to The Tower of Pisa. Jordan gets savagely quizzed over Ferris Bueller's Day Off and we finally discover a binge watchers qualifier. Gary Busey is in trouble again and we debate whether or not he is even aware of actions anymore, and we invent adult leashes.Listen now at: https://www.bwpodcast.com/recent-episodesSubscribe for new content: https://bit.ly/SUBBWPODHorror movies. Movie News. Movie Stories and More. Adventures in Binge-Watching From the Professional Binge-Watchers on this Late Night Comedy and Movie Podcast Hosted by JOHNNY SPOILER. Joined by his film-making buddies, DANGEROUS DAVE and JORDAN SAVAGESupport the show

Deuxième épisode de la série sur les systèmes scolaires les mieux classés au Pisa. Pour « La Story », le podcast d'actualité des « Echos », Michèle Warnet et son invité Yann Rousseau plongent dans l'obsession coréenne où l'excellence et la réussite à tout prix commencent à interroger la société.La Story est un podcast des « Echos » présenté par Michèle Warnet. Cet épisode a été enregistré en juillet 2022. Rédaction en chef : Clémence Lemaistre. Invité : Yann Rousseau (correspondant des « Echos » à Tokyo). Réalisation : Nicolas Jean. Musique : Théo Boulenger. Identité graphique : Upian. Photo : Chung Sung-Jun/AP/SIPA. Sons : La Sonothèque, Sound Fishing, Imagine your Korea, « Suneung » (2014), « SKY Castle » (2018). Notre politique de confidentialité GDPR a été mise à jour le 8 août 2022. Visitez acast.com/privacy pour plus d'informations.