Podcasts about cellular ageing

We talk to one of the world's leading experts on cellular ageing including the molecule that changed it all – and the innovative, award-winning, *data-led* supplement that everyone is talking about.

New data...new ideas...new-age probiotics PLUS vaginal health, the skin's microbiome - and the interesting role of prebiotics.

Dr. Marco Demaria is an Associate Professor in Cellular Ageing at the Medical Faculty of the University of Groningen. In 2018, he co-founded a start-up company, Cleara Biotech, devoted to developing anti-senescence drugs. Today, Dr. Demaria shares his insights and research on how senescence promotes aging and factors that promote the creation of senescent cells. In this episode, Dr. Demaria explains what cellular senescence means and discusses the good and bad that comes with having senescent cells in the body. He explains the role of senolytics in combating senescent cells and how senescent cells could be the cause of the severity of COVID in older people. In this episode, you'll learn how senescent cells contribute to aging, the evolution of the senescent field, some current studies in the field, and what Dr. Demaria hopes to see in the field in years to come. Episode Highlights: What is cellular senescence? The positive and negative sides of senescent cells The role of senescent cells in aging What is the heterogeneity of senescence? Using senolytic drugs to eliminate senescent cells How does hypoxia affect senescent cells? The relation between senescence and COVID in the elderly Dr. Demaria's progress in his study and work at Cleara Biotech The evolution of the senescence field in the past 12 years Experiments Dr. Demaria would like to see done Quotes: “A cell that is in an early senescence state seems to be different from a senescence cell in a late state.” “The next generation of senolytic drugs should definitely focus on dissecting the targets that they want to reach, because of the potential side effect of administering a general senolytic that could interfere with beneficial senescence.” “What we call senolytic drugs and compounds are mostly repurposed drugs.” “We also want to make this study of stem cell longevity in mice and in mouse tissues, because we think that might be another mechanism by which we can improve health, which is maintaining the stem cell pool because we retard the aging of the stem cells.” “There are two prominent senescence groups that are now using senolytics in the clinic for COVID-19 patients.” “There is no magic bullet so far that we have found but just because we haven't probably combined the right interventions at the right moment in the right context.” “The experiments I would like to see done are to combine approaches that target different aspects of aging.” Links: Email questions, comments, and feedback to podcast@bioagelabs.com Translating Aging on Twitter:https://twitter.com/BioAgePodcast ( @bioagepodcast) BIOAGE Labs Websitehttps://bioagelabs.com/ ( BIOAGELabs.com) BIOAGE Labs Twitterhttps://twitter.com/bioagelabs?lang=en ( @bioagelabs) BIOAGE Labshttps://www.linkedin.com/company/bioage-labs/ ( LinkedIn) Cleara Biotechhttps://www.clearabiotech.com/ ( Website)

A trio of genes may be key to making cells young again, and ultra precise measurement of a fundamental physics constant.In this episode:00:47 Reversing ageingResearchers claim to have identified a method to revert cells in mice eyes back to a younger state.Research article: Lu et al.News and Views: Sight restored by turning back the epigenetic clock09:39 CoronapodWe discuss emergency-use approvals for COVID-19 vaccines. Approvals are coming in fast, which presents a dilemma for scientists - they’re critically needed, but what could it mean for research?News: Why emergency COVID-vaccine approvals pose a dilemma for scientists27:04 Research HighlightsAncient megalodon nurseries, and predicting mud volcanoes.Research Highlight: Even Earth’s largest-ever sharks needed nurseries for their babiesResearch Highlight: How mud volcanoes are born under the sea29:38 Fine measurement of the fine-structure constantThe fine structure constant is a fundamental number that gives researchers an understanding of the laws of the universe. For years, scientists have been trying to get better measurements of it. This week, we see the most precise measurement yet.Research Article: Morel et al.News and Views: Fine-structure constant tests standard model35:00 Briefing ChatWe discuss some highlights from the Nature Briefing. This time, a holistic plan to tackle climate challenges, and the rarest pollinator of them all - a lizard.Washington Post: An ancient people with a modern climate planThe Guardian: Is it a bird? Is it a bee? No, it’s a lizard pollinating South Africa’s ‘hidden flower’

Nick pursues nutrition research in England at Oxford before continuing his Med school at Harvard. How Keto saved his life and how the traditional healthcare system left him broken...literally. Nick’s Oxford University Bio: https://www.dpag.ox.ac.uk/team/nicholas-norwitz Nick’s Author’s Page on MDlingo: https://mdlingo.com/author/nicholas/ Nick’s Medical Case Report: https://www.ncbi.nlm.nih.gov/pubmed/30972028 Nick’s Valedictory Address to Dartmouth: https://www.youtube.com/watch?v=wsjPdmgJsPc The Strength Community Gives: https://www.wcvb.com/article/sea-lions-steal-boat/30411256 Healing Self Book: https://www.amazon.com/Healing-Self-Revolutionary-Supercharge-Immunity/dp/0451495527 Eran Segal TEDtalk: https://www.youtube.com/watch?v=0z03xkwFbw4 Yoga and Mindfulness on Telomere Length and Cellular Ageing: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278216/ https://mdlingo.com/21st-century-fitness-what-does-it-mean-to-be-fit-in-modern-western-society/ About Olive Oil: https://www.ncbi.nlm.nih.gov/pubmed/28389247 https://mdlingo.com/olive-oil-weight-control-mental-health/ https://mdlingo.com/the-virginity-lie-how-to-find-real-extra-virgin-olive-oil/

Why do cells die? Can we stop them, and should we?

Transcript -- Why do cells die? Can we stop them, and should we?

Why do cells die? Can we stop them, and should we?

Transcript -- Why do cells die? Can we stop them, and should we?