Podcasts about Senescence

Surya, a tech historian, buys an old Sun workstation at a garage sale, expecting a working example of a CPU her grandmother designed, not secrets. Accidentally left on the drive are two files of NASA's lost Voyager 2 data. When she attempts to learn about the workstation's history by contacting a name she discovers in one of the files, she attracts unwanted attention: break-ins, shadowy men, and veiled threats. She eventually tracks down Mark Danforth, a retired engineer now fading into dementia, who may hold the key. But someone will do anything to keep the files she has discovered buried. CONNECT WITH US makeshiftstories@gmail.com SHARE THE PODCAST If you liked this episode, tell your friends to head over to Apple Podcasts and subscribe. CREDITS Written by Vern Hume (AKA Alan V Hare). Read by Kathleen Connelly. Opening and closing were composed and created by Matthew Erdmann. Produced by Vecada Studios. Makeshift Stories is released under a creative commons non-commercial attribution, no derivative license.

Send us a textBilu Huang ( https://biluhuang.com/ ) is a visionary scientist dedicated to finding solutions to some of the most pressing challenges facing humanity. His interdisciplinary work spans multiple fields, including biological aging, dinosaur extinction theories, geoengineering for carbon removal, and controlled nuclear fusion technology.Born in Sanming City, Fujian Province, Huang is an independent researcher whose knowledge is entirely self-taught. Driven by curiosity and a relentless pursuit of scientific exploration, he has achieved numerous research results through his dedication and passion for science.As a talented theoretical gerontologist,  he proposed the Telomere DNA and ribosomal DNA co-regulation model for cell senescence (TRCS) and he is now using this latest theory to develop biotechnology to rejuvenate cells which will be used to completely cure various age-related degenerative diseases and greatly extend human life at Fuzhuang Therapeutics ( https://lab.fuzhuangtx.com/en/ ).#Aging #Longevity #BiluHuang #FuzhuangTherapeutics #TelomereDNAAndRibosomalDNACoRegulationModelForCell #Senescence #TRCS #DinosaurExtinctionResearch #CarbonRemovalTechnology #ControlledNuclearFusion #TelomereDNA #RibosomalDNA #CellularAging #GeneticProgram #Telomere #P53#ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #ViralPodcast #STEM #Innovation #Technology #Science #ResearchSupport the show

Dr. Monty Pal and Dr. Mina Sedrak discuss the science behind cancer treatment-induced accelerated aging and the development of drug therapies and technologies aimed at helping older patients and cancer survivors. TRANSCRIPT Transcript: Cancer and Aging: Researching the Path to Longer, More Vibrant Lives Dr. Monty Pal: Hello, and welcome to the ASCO Daily News Podcast. I am Dr. Monty Pal. I am a medical oncologist and professor and vice chair of medical oncology here at the City of Hope Comprehensive Cancer Center. I am also host of this podcast. Today, we are going to be talking to somebody that I consider to be my little brother, if you will, in oncology, Mina Sedrak. Mina is an expert in the area of cancer and aging, which really includes the development of drug therapies and technologies that help enable older adults and survivors to live longer, healthier, and more vibrant lives. I am really excited to chat with him. He is an expert not just in cancer and aging but also breast cancer. He was my former colleague here at City of Hope before he moved over to the UCLA Jonsson Comprehensive Cancer Center, where he is an associate professor and director there of the Cancer and Aging Program. Dr. Sedrak's research involves mechanisms behind cancer treatment-induced accelerated aging and really aims to take this science into more of a therapeutic direction, which I am super, super excited about.  Mina, thanks so much for joining us today, and just FYI for our listeners, we have all of our disclosures in the transcript of this episode. Dr. Mina Sedrak: Thank you, Monty. Thank you, Dr. Pal, for having me. I am really excited to be here. Dr. Monty Pal: I feel like we have to go on a first-name basis here with how well we know each other. So Mina, you and I together have witnessed this evolution in cancer and aging. I mean, both of us worked together here with just a legendary figure in the field of geriatric oncology, I will call it, Dr. Arti Hurria, mentor to me, mentor to you, mentor to so many. Can you give us a sense of where cancer and aging has gone since the time that you and I started here together at City of Hope? Dr. Mina Sedrak: Dr. Hurria and her collaborators, Dr. [Willliam] Dale and Dr. [Supriya] Mohile, they were like huge pioneers in the field. They were one of the very first people to highlight the importance of looking at older adults beyond just their chronological age and their comorbidities and moving us beyond just seeing patients and making decisions using what we call the eyeball test. "Oh, this person looks fit or not fit, frail or robust," to really using objective measures to assess our patient's health status and incorporate that assessment into our evaluation of the treatment, prognostication, and discussions with our patients throughout the cancer continuum. And so that is what geriatric oncology has and continues to be, and it is a huge, important part. And their work has laid the foundation to show that when we look at our patients beyond just their chronological age and we look at their functional age, and we do these objective assessments, we can gain much more deeper information to tailor the treatment for our patient that is sitting in front of us, rather than do a prescriptive treatment or over- or undertreatment in that population. So that is sort of where the field is growing, and a lot of the work now is, how do we implement that? How do we put that into clinical practice? Dr. Monty Pal: Well, let me kind of spearhead that discussion, right? I have these moments when I go to the ASCO Annual Meeting – I remember this happened to me a while ago when Dr. Jennifer Temel presented that terrific work around early palliative care interventions, right? Or it even happened to me this year, right, when Dr. Christopher Booth presented the CHALLENGE trial around exercise and colon cancer. You know, these amazing, I am going to say simple, they are not simple, but they are simple interventions relative to, you know, some of the complex drugs and mechanisms that we are using nowadays that really help outcomes for our cancer patients. The big question becomes, how do you implement, right? But my understanding is that there are easy ways for us to take tools in cancer and aging and sort of plug them into our daily practice. Am I right about that? Dr. Mina Sedrak: Yes, and that is something that they are – the Cancer and Aging Research Group, which was founded by Dr. Hurria and now is co-led by Dr. Dale, Dr. Mohile, and Dr. [Heidi] Klepin, they have been incredible at really trying to develop practical tools, like the Practical Geriatric Assessment, which is now endorsed by the ASCO and other NCCN guidelines. And so, there are tools that are becoming more and more practical to help incorporate that into clinic.  Now, what might be practical in a resource-intensive setting may not be practical in some of the limited resources, whether it is rural and/or other countries where the resources may be more limited. So that is why Cristiane Bergerot, Enrique Soto, and others have been really working hard. There was actually a really beautiful paper that was just published in the Journal of Global Oncology, where they have shown that there are guidelines [ASCO Geriatric Assessment Global Guideline] about how to implement these tests, these tools, these assessments in clinical practice, even in different resource settings. So I think we are going to get to the future where this is much more – it is definitely important, but it is much more easily ‘incorporatable' into our practice. Dr. Monty Pal: Yeah, you know how close I am to Cris, and I was so proud when I saw that paper come out. That was really exciting. You know, I skimmed it. I have to tell you, I did not get into the weeds, but it was apparent to me that, you know, some of these geriatric oncology tools are things that, you know, I could probably plug and play into my practice where I am double- and triple-booked over, you know, most slots, right? I mean, I could still probably afford a little bit of time or maybe have, like, a nurse or an extender kind of help participate in the evaluation process. I thought that was, yeah, really, really interesting. Dr. Mina Sedrak: I will just say that at UCLA, we are working with Dr. Arash Naeim, who is a geriatric oncologist, and he has developed an AI platform where the assessments can be done by an AI computer. So it is like talking to your ChatGPT. They can talk to you, and for a few minutes, they will ask you the questions. So you do not even have to fill it out on a piece of paper. You could give the patient a little iPad, put them in a private room while they are waiting for their doctor, and get the results, and it is right there for you. And so, we have been trying to think about how can technology help with the completion of the assessment, at least doing that? And I think it is actually, it has been very cool. We did a pilot study. He is writing that up, and we are going to continue to do some of this exciting work. How do we think about AI in the context of this? And, you know, older adults, they are not like what they used to be. A lot of older adults are very familiar with and comfortable with phones and computers and iPads, much more so today than they were even at the time when Dr. Hurria was alive. Dr. Monty Pal: That is so interesting. You mentioned this, the AI approach is something I have been thinking about in this context because what if, for instance, you know, we have got video monitors all over our hospital, right? What if you are actually just taking a look at that patient as they make their way towards your clinic? Capture that video, use an AI algorithm to say, "Hey, you know, the timed get-up-and-go test in this patient is not particularly good based on what I am seeing here," right? There are so many ways that you could, you know, stir the pot and come up with creative ways to get these tests done. Dr. Mina Sedrak: That's right. And Arash is looking at also sensors. So he has some studies where he is putting sensors inside people's homes, where they would put them, like, on top of an Alexa app or the equivalent. A lot of people have these apps, and basically, they can sense how you are moving around and what you are doing, just movement-wise. And then they can collect that information to gain information about your life beyond just what we are seeing in the 20-minute visit in the clinic. Even when I do a walk test where I get gait speed or physical performance, short physical performance battery, the chair sit-up, those are oftentimes a single, cross-sectional, static measure. But what about the dynamic ability of capturing what has been happening for the last 7 days? What has been happening for the last 25 days between the visits, between the cycles of chemotherapy? And could that inform how I make decisions when I see patients and who do I need to target and identify? And so, we are very excited because really at UCLA, Arash is leading the technology efforts and thinking about implementation of these important measures and these important tools but leveraging new technology. And we do not want to be behind; we want to be ahead of the game. Dr. Monty Pal: I love that idea because there is a Hawthorne effect, isn't there, where you observe a process, and it naturally gets better. I mean, when you ask that patient to get up in the clinic and move, they are probably functioning to the best of their abilities, but we could probably learn a lot from just watching how fast that patient picks up a remote control at home. Some simple movement like that that is volitional would probably help out a ton. And I got to tell you, it is so funny when you mention Arash Naeim's name. I distinctly remember him serving as an attending on the wards when he was brand new at UCLA on faculty when I was a resident there. And his dad is a legendary hematopathologist, right? Dr. Mina Sedrak: I did not know that. Dr. Monty Pal: Yeah, yeah. Faramarz Naeim wrote the book on a lot of heme-path malignancies. Incredible guy. Very, very storied hematopathologist at UCLA.  I could probably go on this topic forever, but in the interest of time, I am going to shift to something that again, I could probably talk about forever, which is this area of senescence that you are involved in. You know, you had mentioned this to me, I am going to say during your outro from City of Hope and towards your transition to UCLA, it is such an exciting area. I mean, understanding the actual biologic process of aging and using those underpinnings to really sort of tailor therapy. So tell us where the state of the science is there with this body of work that you are doing. Dr. Mina Sedrak: As I said before, we have tools now to assess patients and to then do something about the deficits. So if a patient is falling, what we do is we refer them to physical therapy where they can do fall precautions and strength training to give them the information. But all of these supportive care interventions are very important. They are great. But they oftentimes are not targeting the root cause of why they are happening. And so that is really where I have been very interested in, how can we understand why is it that something like chemotherapy or immunotherapy is causing a decline in cognitive function or a decline in physical function? And so that has really led us to think about geriatric oncology rather than a discipline of older adults, but to think about aging as a physiologic process. We are all aging. As every day goes by, we are aging. And what that means is that our bodies are accumulating damage, the cells are being exposed to various stressors, and the repair mechanisms are declining. And as we get older, it is really more damage and less repair mechanism at the cellular molecular level. And it turns out that these processes of how our cells repair and respond to damage are fundamental processes of biological aging. And there has been a large amount of preclinical and now really exciting clinical work to show that there are hallmarks that could be used to assess the rate of which we age by looking at these processes. And that includes things like epigenetics, telomeres, inflammation, and something called ‘cellular senescence.' And we have been interested in my lab in senescence because it is a unique process that has an important role in aging, but it also has a really important role in cancer. Senescence is a cell state. Cells, when they are stressed, they respond to entering this state of senescence. The stress could come from anything. It could come from an oncogene activation. It could come from a reactive oxygen species. It could come from a direct damage to the cell. But it is a cell state, just like apoptosis, necrosis. Senescence is a state in which the cell, in response to that stressor, undergoes an arrest from the G to the S phase. And that arrest is oftentimes associated with a resistance to apoptosis. So then the cell does not die, but it is alive, and it remains metabolically active. And in fact, downstream pathways of these cell cycle inhibition of this G-to-S phase lead to the increase of these transcription factors in the chromatin and lead to the development of these pro-inflammatory factors. So these cells, which can occur in various tissues in the body, can continue to live despite having developed these changes, and then they secrete these proinflammatory molecules like cytokines, chemokines, metalloproteinases, all of these, which are called the senescence-associated secretory phenotype, or SASP. And as we age, we accumulate more and more of these cells, and our bodies are no longer able – our immune system, like macrophages and T cells – are no longer able to remove them effectively. And as we accumulate them in various organs, these organs release a lot of inflammatory cytokines, and the chronic inflammation in that tissue leads to the tissue being damaged, and it does not work as well, and then it starts to decline in function. And that is believed to be how senescence plays a role in aging. It is the accumulation of senescent cells that occurs with increased damage and then the repair mechanism of clearing these cells effectively, which then leads to build up of inflammation and chronic inflammation leads up to damage in multiple tissues. Dr. Monty Pal: This concept to me is fascinating. And I guess the big question is – senescence is bad, right – is it not reasonable to think that this body of research, I mean, if you are able to sort of have a meaningful impact on senescence, it could have implications well beyond oncology. Is that fair? You really could extend lifespan all around. Is that reasonable to think, all-cause mortality? Dr. Mina Sedrak: One hundred percent. And that is what they have been shown in animal models. And the reason senescence is exciting is because it turns out that you can target these cells and you can induce apoptosis of these cells, but it requires active targeting of various pathways, but it can occur. And when it does, and it is done either genetically or pharmacologically in mice, we see that the mice can reverse damage. So if you take an old mouse and you genetically engineer it to remove senescent cells, that mouse will go from being frail to fit. And if you take a young mouse and you induce senescent cells at a high rate and you accumulate them in that mouse, that mouse, even though it is young, will become frail.  So that has really led to this exciting opportunity of, can we translate this finding that we are seeing in animals and in in vivo cells, cell cultures, into humans? And could that have a benefit beyond just one disease? Could it have a benefit in multiple diseases? And not just really longevity, which I think it would be great, but what people are really looking for is, how do we live healthy as we get older? How do we move the curve so that people are not developing chronic diseases in their 60s, but they are developing them in their 80s towards shortening the period of their life with disability rather than what we have currently, which is people are living to 70s, the average life expectancy is in the mid-70s, but they are spending 10 or 11 years in disability of that life. And so, how could we reduce that time frame? Dr. Monty Pal: This is brilliant, Mina. And for our audience, this compelling dialogue that we have had here thankfully is translating to funding for Mina's work. He just scored in the second percentile for his NIH R01 based on this topic. We are so, so proud of you. I mean, it is just remarkable work. It is not easy in the current climate to get funding, and a second percentile score is just absolutely wonderful. You know, Mina, I could probably go on with you for a couple more hours here talking about your work in cancer and aging. I think I am going to have to have you back on the podcast here. But a million thanks for sharing your thoughts here today on the ASCO Daily News Podcast.  And thanks to our listeners too. If you value the insights that you heard today on the ASCO Daily News Podcast, please do not forget to rate, review, and subscribe wherever you get your podcasts. Thanks, Mina. Dr. Mina Sedrak: Thank you so much. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Find out more about today's speakers:     Dr. Sumanta (Monty) Pal   @montypal  Dr. Mina Sedrak @minasedrakmd   Follow ASCO on social media:      @ASCO on Twitter     ASCO on Bluesky    ASCO on Facebook      ASCO on LinkedIn      Disclosures:     Dr. Monty Pal:    Speakers' Bureau: MJH Life Sciences, IntrisiQ, Peerview   Research Funding (Inst.): Exelixis, Merck, Osel, Genentech, Crispr Therapeutics, Adicet Bio, ArsenalBio, Xencor, Miyarsian Pharmaceutical   Travel, Accommodations, Expenses: Crispr Therapeutics, Ipsen, Exelixis   Dr. Mina Sedrak: Patents, Royalties, Other Intellectual Property: Up-to-Date

ReferencesCells. 2019 Nov 5;8(11):1392Nature Immunol. 2025. volume 26, pages 866–880 Nat. Immunol. 2021. 22, 1440–1451 (2021).Cell Rep. 2021. 36, 109521 .J of Sleep Res. 2025. July. Avail. online: https://onlinelibrary.wiley.com/doi/10.1111/jsr.70130?af=RJ Biol Rhythms. 2020 Dec;35(6):555-575.Blood (2023) 142 (Supplement 1):3458.Cell. 2011. 146, 772–784, September 2,Nat Immunol. 2011 Nov 6; 12(12): 10Lennon/McCartney. 1968. "Goodnight" White Albumhttps://music.youtube.com/watch?v=Qp_djIuQ2Cw&si=elD9HBuTp3xqF1oHDvorak, A. 1893. Symphony 9. in E Minor "From The NewWorld".https://music.youtube.com/watch?v=390BSJWTiXo&si=QwHmMJGGbSOikSCV

ReferencesGuerra, DJ. 2025 Unpublished LecturesHaggard, M. 1966. Lonesome Fugitive. Roy Buchanan coverhttps://music.youtube.com/watch?v=sA5s9l3omyc&si=WG7vxP1fgh5f5FJVVan Zant and Collins. 1973. Tuesday's Gone. Lynard Skynyrdhttps://music.youtube.com/watch?v=LJrFxnvcWhc&si=jVT0uoJwjgg6ih9uBetts, D. 1972. Blue Sky. Allman Brothershttps://music.youtube.com/watch?v=JSMubgZoL58&si=7mhrTU-5kM8FzhTVYoung, R. 1978. Crazy Love . Pocohttps://music.youtube.com/watch?v=7Ki7f4g9X9g&si=BcuD4PS5f9EAIW7gRichards/ Jagger 1975.Wild Horse. Rolling Stoneshttps://music.youtube.com/watch?v=nY_GgPi5eCM&si=0grJAl9jfiQq3wDB

ReferencesCell Reports2016 V 17, Issue 11, 13 December 2827-2836Cell 2011. 146, 772–784, September 2, Mol Oncol. 2022 Jun 19;16(18):3295–3318.Int J Mol Sci. 2023 Dec 5;24(24):17129Walsh, J. 1973. Rocky Mountain Wayhttps://music.youtube.com/watch?v=Rt75y38J00s&si=A3-SeEqcT2RDUdie Paige, J. 1971 Misty Mountain Hop' Led Zepplinhttps://music.youtube.com/watch?v=n6fBQRaygeo&si=4lwil78xJIh4L4sF

BUFFALO, NY — September 2, 2025 — A new #research paper featured on the #cover of Volume 17, Issue 8 of Aging (Aging-US) was #published on July 30, 2025, titled “Exosomes released from senescent cells and circulatory exosomes isolated from human plasma reveal aging-associated proteomic and lipid signatures.” In this study, led by first authors Sandip Kumar Patel and Joanna Bons, along with corresponding author Birgit Schilling from The Buck Institute for Research on Aging, researchers found that exosomes—tiny particles released by cells—carry molecular signatures that indicate both biological aging and cellular senescence. These signatures include proteins, lipids, and microRNAs associated with inflammation, oxidative stress, and tissue remodeling. The findings could enhance our understanding of biological aging and help in developing future anti-aging therapies. Senescence is a state in which cells stop dividing but remain metabolically active. These cells often release harmful substances, known collectively as the senescence-associated secretory phenotype (SASP), that can affect nearby tissues. This study shows that exosomes are an important component of this secretory profile. The researchers analyzed exosomes from senescent human lung cells and from the blood plasma of both young and older adults. They identified over 1,300 proteins and 247 lipids within these particles. Many of these molecules were significantly altered with age. “In parallel, a small human plasma cohort from young (20–26 years) and old (65–74 years) individuals revealed 1,350 exosome proteins and 171 plasma exosome proteins were altered in old individuals.” Exosomes from older individuals contained more inflammation-related proteins and fewer antioxidants, while those from senescent cells showed lipid changes associated with membrane integrity and cellular stress. These changes suggest that exosomes may play a role in spreading senescence to nearby cells, a process known as secondary senescence. The study also identified distinct patterns in microRNAs—small molecules that regulate gene expression—found in the blood of older adults. Some of these, including miR-27a and miR-874, have previously been associated with cognitive decline and chronic illnesses, highlighting their potential as biomarkers for biological aging. Although the study involved a limited number of samples, it provides strong early evidence that exosomes reflect the molecular changes associated with aging. By showing how these particles carry and possibly spread aging-related signals throughout the body, the research opens new possibilities for diagnosing and treating age-related diseases. DOI - https://doi.org/10.18632/aging.206292 Corresponding author - Birgit Schilling – bschilling@buckinstitute.org Video short - https://www.youtube.com/watch?v=tcyAZahw-g8 Keywords - aging, proteomics, senescence, exosomes, data-independent acquisitions Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

ReferencesPNAS 2021. July 23, 118 (30) Front. Immunol.,2022. 02 February Sec. Parasite Immun. V.13 Sci Transl Med . 2021 Mar 31;13(587):eaaz6314Cytokine 2012. Volume 60, Issue 1, October Pages 1-12.Morrison/ Doors. 1970. "Blue Sunday" https://music.youtube.com/watch?v=ENIbGONsdUg&si=4o_N-2AO2G6R6segCroce, J. 1970. "Time in a Bottle"https://music.youtube.com/watch?v=Q29sOLG8xGE&si=QPz_DpvfNBiqntPgSimon, P. 1966. "Kathy's Song"https://music.youtube.com/watch?v=ylCGvOUL938&si=8zEONmyedOtB_EqsSchubert, F. 1826. "Standchen" D889https://music.youtube.com/watch?v=pJf-XXTBEqs&si=z4blmyDOFbcSEzFtHunter/Garcia. 1970. "Ripple"https://music.youtube.com/watch?v=sFBQSx_xc2o&si=vM-FGkQzzsnnTN_G

ReferencesCell Reports 2015. 10, 2043–2054, March 31, Eur J Immunol. 2024 Sep;54(9):e2350379. Cell Death & Disease.2019. volume 10, Article number: 315 Haydn, M. 1764. Wind Concerti (Trombone and Horn Vol.1 )https://music.youtube.com/playlist?list=OLAK5uy_k0pQ-x0vlXIRe1JYORpet7tTrY1kjx9Oc&si=4C7YfJAqjhjHPtNY LaFlamme, D&L. 1967. "White Bird" It's a Beautiful Dayhttps://music.youtube.com/watch?v=zFCC9Uet7M8&si=cWiRy39RSPXz7iLy

ReferencesFront.Immunol., 2020 Sec. T Cell Biology V 10 Eur J Immunol. 2020 Oct 26;50(11):1626–1642Nat Immunol. 2015 Nov;16(11):1174-84.Guerra, DJ 2025. Unpublished LecturesHunter, R. 1975 "Cruel White Water"https://music.youtube.com/watch?v=EhdcOs7k3io&si=W1MV_Qzd0VIjyuJqHunter, R. 1975. "Yellow Moon"https://music.youtube.com/watch?v=JwofJXgc3CE&si=b9ibX8ef6MJJYquxWinwood,/Capaldi/Wood. 1967. "Dear Mr. Fantasy" Live TRAFFIChttps://music.youtube.com/watch?v=epyHwMCw4hg&si=cIdqdKnkVz_FdixcClapton/Gordon. 1970. "Layla"https://music.youtube.com/watch?v=TngViNw2pOo&si=Y25k2CMZ9XgG5X9qValenti, D. 1975. "Cowboy on the Run"https://music.youtube.com/watch?v=ZREiCmVrAHc&si=we5Slq1nE7k6QEeB

ReferencesFront. Immunol 2020. 03 February Sec. T Cell BiologyGeneReviews®[ [updated 2024 Feb 1] Seattle (WA): University of Washington, Seattle;Open Biol. 2020 Dec 16;10(12):200295.Cell. 1989 May 19;57(4):645-58. Journal of Genetics and Genomics 2020.V. 47, Issue 1, 20 January Pages 17-26Plant/Paige. 1975 "In the Light". on Physical Graffitihttps://music.youtube.com/watch?v=pNo1nS_JV5k&si=aD1HwJTkegLhjRCRLodge, J. 1969. "Candle of LIfe" To Our Children's Children." lp. Moody Blueshttps://music.youtube.com/watch?v=BVkIUY2s-7o&si=F5GrPlT-hklKTTGqDobson .B. 1961. "Morning Dew" Grateful Dead Europe 72'. lphttps://music.youtube.com/watch?v=jYR3sBmomgQ&si=vLBLIStvXYBFoaJc

ReferencesCancer Science   June 2014. 105(9)Sci Transl Med. 2021 Mar 31;13(587) Front. Immunol., 02 February 2020 Sec. T Cell Biology. V.10 Guerra, DJ. 2025. Unpublished LecturesMozart, WA. 1791. Requiem Mass in D Minor. K 626.https://music.youtube.com/playlist?list=OLAK5uy_nSNY0VtEjG1DYcoE6gg9tibETknwAWeLY&si=0zWjhWxBojiGyueD

ReferencesGuerra, DJ. 2025. Unpublished lecturesTrends in Immunology. REVIEW.2017. V. 38, ISSUE 4, P287-297, APRIL 01.Nat Rev Genet. 2025 Jan;26(1):7-30.Bruce/Clapton/Baker. 1968. Wheels of Fire lp. Cream.https://music.youtube.com/playlist?list=OLAK5uy_kFv6q_z5W4BZfkKZDowVKYyxdWi6mR_Yc&si=ruW790pL_RybELtS

ReferencesCells.2019 Sep; 8(9): 1047.Pharmacological reviews2011. November.64(1):166-87Mol Aspects Med. 2013 Jan 25;34(6):10.1016Curr Opin Pharmacol . 2021 Apr:57:107-116Frey and Hendley 1973. Desperadohttps://music.youtube.com/watch?v=SwkOq_je_iQ&si=SBeqfJmu6vxzUw5UZevon, W. 1976. Desperadoes Under the Eaveshttps://music.youtube.com/watch?v=wXCly4X3cqw&si=aC5G-U_yYl-wBZz8Stewart/Quittenton. 1971.. 1973. Maggie May.https://music.youtube.com/watch?v=jubOWUlkxuk&si=YQm1Gq49yCiJ8QEuThorogood. G. 1982.Bad to the Bonehttps://music.youtube.com/watch?v=IyhJ69mD7xI&si=BhdCLEeAszDwtYTBZevon, W. 1980.Bill Lee.https://music.youtube.com/watch?v=eUTbClvDtMU&si=acZB4n01zTOhJw8h

ReferencesAging Cell. 2024 Jan;23(1):e13920.Guerra, DJ. 2025. Unpublished Neurobiochemistry LecturesAutonomic Neuroscience: Basic and Clinical. 2015. Volume 192, NOV. 21Lesh/Hunter. 1970. Box of Rain. Grateful Dead. American Beauty.https://music.youtube.com/watch?v=S4sAp9mLaHQ&si=JJzWNwo0A-dPGvNSMason, D.1967. Hole in my Shoe. Traffichttps://music.youtube.com/watch?v=MPPe8-1G2s0&si=CsIkjStt_cjHy0r0Mason, D.. 1968. "Crying to be Heard" Traffic.https://music.youtube.com/watch?v=4rZZudSiJAs&si=ymeja1e0kiASidJJLennon/MCartney.1966."Eleanor Rigby" Revolver. Beatles.https://music.youtube.com/watch?v=wbxTlxuECJA&si=EzKT49wNhxVbv6g1Mozart, WA. 1791. "The Magic Flute" Overture K 620.https://music.youtube.com/watch?v=99VWYcapgq4&si=lMkCf3FHefloImbI

ReferencesInt J Mol Sci. 2019 Mar; 20(5): 1223.Int.J. Mol. Sci. 2014, 15, 16848-16884Nat Immunol. 2021 Mar; 22(3): 312–321Guerra, DJ. 2025. Unpublished lecturesHunter/Garcia, 1974. "It Must Have Been the Roses". https://music.youtube.com/watch?v=OhFGxZZpdls&si=crIWlTb75mJpQFBQAllman/Payne 1970. "Midnight Rider" https://music.youtube.com/watch?v=Z8zk7XKyoE8&si=LLG_ilnORFPdA886Hunter/Garcia, 1969. "Doin' That Rag. Aoxomoxoa.. lphttps://music.youtube.com/watch?v=r-l2PleOO6k&si=h7k_jtenfqdRabyQPhillips, J. 1963. "Me and my Uncle" Grateful Deadhttps://music.youtube.com/watch?v=trJcxc55YvM&si=_Kgt3esme9PAKe9Z

ReferencesJ of Neurochemistry. 2019. 151, 6. December 676-688Zool Res. 2023 Jan 18;44(1):183–218Cancers (Basel). 2023 May 11;15(10):2716St Benedict (and subsequent). 500 AD-1000 AD. Gregorian Chants.https://music.youtube.com/watch?v=xERuXyDeVqc&si=qeDSQF2Vom3JK4P3

ReferencesJAMA. 2024 Dec 10;332(22):1924–1935. Signal Transduction and Targeted Therapy 2019. volume 4, Article number: 7 Nature. 2020 Jun 17;583(7814):127–132. Front Immunol. 2017 Mar 17;8:292 Cancer Lett 2024 Jul 1:593:216930.Hunter/Garcia. 1971. "Wharf Rat" Grateful Dead https://music.youtube.com/watch?v=P6NDmh86RAI&si=0PXjoDXD_4LRt4VrHunter/Garcia. 1971 "Bertha" Grateful Dead.https://music.youtube.com/watch?v=82ADE0DUeM4&si=cv5hDcNQ4P_TzhX_

ReferencesCancer Letters 2024. Volume 593, 1 July.216930Nature Review Genetics 2019. v. 20. November 657-674.Lennon/McCartney. 1965. "Things We Said Today"https://music.youtube.com/watch?v=NItAlTsPuQg&si=oWlkf4sV9HyT5RezRossini, G. "The Italian Girl in Algiers" Overturehttps://music.youtube.com/watch?v=8pf5MdTZZDI&si=Hgcf6vVpwQE6jJzRLewis & Wright. 1966. "When a Man Loves a Woman." Percey Sledge.https://music.youtube.com/watch?v=KwPxhWU1koE&si=zNuoJIZHb1VARi5_Ballard, H. 1958 "The Twist". For Teen Twisters. lp. Chubby Checkerhttps://music.youtube.com/watch?v=-CCgDvUM4TM&si=UP7Uv8xiQ4keAXBwLennon/McCartney. 1965. "Girl" Rubber Soul lp. Beatleshttps://music.youtube.com/watch?v=-8l3ntDR_lI&si=aF2Z3egYapJm3ijv

ReferencesDiabetes 2016;65:1606–1615 Cell Physiol Biochem 2023;57:478-511Guerra, DJ. 2025. Unpublished LecturesSchubert, F. 1825. "Ave Maria" OP52 . #6 D.839https://music.youtube.com/watch?v=tDQj7j-xogM&si=Tb_c99saDwqHd_69Montiverdi., C. 1610 Vespro della Beata Vergine https://music.youtube.com/watch?v=AqrTsxQgCt0&si=EAn29lPpqTC_b88N

BUFFALO, NY — August 11, 2025 — Aging (Aging-US) is proud to support a milestone event for the global senescence and aging research community. This coming September 16-19, 2025, Rome, Italy will host two back-to-back events that will define the next chapter of senescence science and translation: -10th Annual International Cell Senescence Association (ICSA) Conference -Senotherapeutics Summit – organized with the Phaedon Institute This combined program could not come at a more important time. The field is entering a transformative phase: -Multiple clinical trials on senolytics and senomorphics are now reporting results, offering the first real-world evidence of their therapeutic potential. -Exciting new discoveries in senescence mechanisms, biomarkers, and tissue-specific roles are reshaping our understanding of when and how to target these cells. For the first time, the leading fundamental science meeting on cellular senescence will be directly connected with a global summit dedicated to the clinical and commercial development of senotherapeutics. This unique integration will allow participants to seamlessly move from bench to bedside discussions, exploring both the latest research and its translation into therapies that could transform how we approach aging and age-related diseases. Highlights include: -Keynotes from pioneers driving both discovery science and translational innovation -Sessions on mechanisms, biomarkers, and emerging targets -Industry and regulatory panels on clinical trial design, safety, and approval pathways -Case studies from ongoing and completed human trials -Networking with leaders from academia, biotech and pharma Celebrate a decade of ICSA and help chart the path for the next generation of senescence science and therapeutics. Registration is still open: https://icsa2025rome.com/ To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Link to Study: https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1616693/fullGet My Book On Amazon: https://a.co/d/avbaV48Download The Peptide Cheat Sheet: https://peptidecheatsheet.carrd.co/Download The Bioregulator Cheat Sheet: https://bioregulatorcheatsheet.carrd.co/

Lucy and Ben have played the same game! We discuss and review Wheel World, a new open-world cycling game from Messhof and Annapurna Interactive. Along with the review, Ben drinks and discusses Senescence from Deya Brewing Company. A review code for Wheel World was provided to us by Popagenda. Originally recorded on the 28th of July 2025.

Menopause is having a moment. Celebrities like Halle Berry, Naomi Watts, and Michelle Obama have recently shared their personal menopause experiences. Menopause and perimenopause are showing up across social media and even in popular books. All this to say, menopause has finally gone mainstream. But, it wasn't until about three decades ago that menopause research really kicked into gear. Since then, scientists have made a lot of progress in understanding the basic biological process as well as treatments like hormone therapy and the importance of separating symptoms of menopause from those of aging. Host Flora Lichtman talks with two menopause researchers, ob-gyn Monica Christmas and epidemiologist Carrie Karvonen-Gutierrez, about what we've learned so far—and what misconceptions bug them most.Guests: Dr. Monica Christmas is an associate professor of obstetrics and gynecology at the University of Chicago and director of the menopause program at UChicago Medicine.Dr. Carrie Karvonen-Gutierrez is an associate professor of epidemiology and the director of the Center for Midlife Science at the University of Michigan.Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

BUFFALO, NY — July 15, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 6, on June 5, 2025, titled “Senescence caused by telomerase inactivation in myeloid, mesenchymal, and endothelial cells has distinct effects on cancer progression.” In this study, first author Joseph Rupert, along with corresponding author Mikhail G. Kolonin and colleagues from The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, McGovern Medical School, at The University of Texas Health Sciences Center at Houston, investigated how aging-related changes in different cell types affect cancer progression. By turning off telomerase in specific cell populations in mice, the researchers discovered that cell aging, or senescence, can slow primary tumor growth but also trigger unexpected effects. This work sheds light on the complex relationship between aging cells and cancer and may help guide future anti-cancer strategies. The team used genetically modified mice to deactivate telomerase, the enzyme that maintains chromosome ends, specifically in immune, connective tissue, and blood vessel cells. This caused these cells to enter a state of senescence, where they stop dividing and release inflammatory signals. The researchers then implanted breast, prostate, and pancreatic cancer cells into the mice and tracked how tumors developed. They found that when telomerase was inactivated in immune cells or connective tissue cells, tumors grew more slowly. However, these tumors showed signs of increased tissue damage and potential aggressiveness. Interestingly, when telomerase was turned off in endothelial cells, which cover blood vessels, tumors shrank and became poorly supplied with blood, leading to oxygen deprivation. In the case of pancreatic cancer cells, this low-oxygen environment made them more likely to spread to the liver, highlighting a potential risk of targeting these cells. “[…] this study shows that senescence and metabolic dysfunction resulting from telomerase inactivation in distinct cells in the tumor microenvironment have different effects on tumor growth and metastasizing of carcinomas.” This research provides important insights into how aging cells within the tumor microenvironment (TME) influence cancer behavior. While senescence in certain cell types can help suppress tumor growth, it may also create conditions that favor cancer metastasis. These findings highlight the need to consider cell type-specific effects when developing therapies that target senescent cells. By mapping how different cell populations contribute to cancer progression in aging tissues, this study opens the door for more precise approaches to prevent both tumor growth and spread. DOI - https://doi.org/10.18632/aging.206268 Corresponding author - Mikhail G. Kolonin - mikhail.g.kolonin@uth.tmc.edu Video short - https://www.youtube.com/watch?v=py8wFKj7enE Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206268 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, senescence, telomerase, myeloid, mesenchymal, endothelial To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Follow Jordyn on instagram: https://www.instagram.com/jordynbarr_/?utm_source=ig_web_button_share_sheetIn this episode, Dr. Jordyn Barr shares her journey from undergraduate research with Drosophila to her PhD work on mosquito physiology at Vanderbilt University. She discusses the impact of climate change on mosquito aging and disease transmission, highlighting her research findings and future directions. Dr. Barr emphasizes the importance of mentorship and teaching in her career, as well as her excitement for her upcoming postdoc at the University of Florida.Join our community on Patreon! https://patreon.com/Lildudes?utm_medium=unknown&utm_source=join_link&utm_campaign=creatorshare_creator&utm_content=copyLinkLil Dudes Insect Academy is a non-profit dedicated to teaching the world about the amazing world of Insects (Entomology). We do this through workshops, classes, courses, resources, and online content! We have a free, family-friendly Podcast where Bradon talks with Entomologists, and we also have a Bug of the Week Series on YouTube!Website: lildudesinsectacademy.comDonate to the Academy: https://www.lildudesinsectacademy.com/donate.htmlFind our free Podcast here: https://www.lildudesinsectacademy.com/media/podcast.html✌️Follow us on:Facebook: https://www.facebook.com/lildudesinsectacademyInstagram: https://www.instagram.com/lil.dudes.insect.academy/Twitter: https://twitter.com/lildudesacademyYouTube: https://www.youtube.com/channel/UCDJx_th0guulNsJPE_75sDgLil Dudes Insect Academy is proud to be registered as a 501(c)(3) non-profit organization. Our mission is to educate anyone and everyone about the amazing world of Entomology, which is the gateway to all the sciences. Contributions to Lil Dudes Insect Academy are tax deductible, to the extent permitted by law. Our Tax ID is: 86-1976172mosquito research, climate change, Drosophila, aging, disease transmission, entomology, graduate school, postdoc, scientific communication, mentorship

  We unpack the UN Scientific Advisory Board Brief on Aging—from telomeres and epigenetic clocks

Can we really reverse biological age?  In this groundbreaking episode, I sit down with Greg Macpherson, biotechnologist, pharmacist, and founder of SRW Laboratories, to explore the cutting-edge science behind reversing biological ageing — backed by real human clinical trial data. We discuss SRW's latest clinical study, which demonstrated measurable reductions in biological age markers through targeted supplementation. Greg unpacks how biological age is assessed using epigenetic markers like DNA methylation, and how SRW's formulations are designed to influence key aging pathways including: sirtuins, NAD+ production, AMPK, and mTOR modulation. What you'll learn from the episode:  What biological age really means  How SRW's trial measured age reversal using TruDiagnostic epigenetic clocks  Key molecules and compounds driving the effect  The importance of cellular senescence, mitochondrial function, and genomic stability  What's next in the field of longevity biotechnology Whether you're a health professional, biohacker, or longevity enthusiast, this episode is packed with science-forward insights and actionable takeaways. Shop SRW supplements here: SRW Supplement Range  Follow Greg Macpherson: Linkedin/Greg Nacpherson SRW  Explore epigenetic testing: Trudiagnostic - TruAge COMPLETE Greg Macpherson: Throughout my career, I have been driven by a desire to help people achieve their potential by overcoming health challenges. As a biotechnologist, futurist, author, and pharmacologist, I have pursued this goal by founding one of the first online pharmacies in New Zealand and creating the country's first Government licensed robotic dispensing facility. My current focus is on understanding cellular aging and developing new formulations to support healthy aging and improve human health. For the past 10 years, I have been researching cellular aging and consulting with global experts in the field. All of this research and experience has led me to establish SRW, an organization that aims to translate scientific advancements into practical solutions for everyday people to live longer, healthier lives.  

Merlyn Silva - Field Trip (Original Mix) Senescence - Sofa Beats SOFABEATS159 1. Merlyn Silva - Field Trip (Original Mix) 2. Merlyn Silva - Meandering 3. Merlyn Silva - Falls Upwards (Original Mix) 4. Merlyn Silva - Unlearning (Original Mix) 5. Merlyn Silva - Red Sky Thinking (Original Mix) 6. Merlyn Silva - Ecocentrism 7. Merlyn Silva - The Swing That Swung (Original Mix) 8. Merlyn Silva - Senescence (Original Mix) Merlyn Silva returns with his fourth album Senescence; a kaleidoscopic ode to the gentle passage of time. Wandering between transcendent downtempo journeys and wiggly dancefloor mischief, Senescence is a refinement of Merlyn's leftfield take on psychedelic electronic music. From the euphoric downtempo of "Unlearning" to the mooching grooves of "Meandering", Senescence creates a space where acousmatic field recordings can drink chai and high-five with contemporary synth workouts and dank midtempo beats. As the album evolves it's hard not to notice the parallel to the dramatic seasons of Northern Europe, staring lighthearted and optimistic before culminating in the introspective deepness of title track.

Bret speaks with Dr. Lon Jones, DO on the subject of the mismatch between modern humans and the environment they live in. Find Dr. Lon Jones, DO at https://commonsensemedicine.org*****Join DarkHorse on Locals! Get access to our Discord server, exclusive live streams, live chats for all streams, and early access to many podcasts: https://darkhorse.locals.comCheck out the DHP store! Epic tabby, digital book burning, saddle up the dire wolves, and more: https://www.darkhorsestore.orgTheme Music: Thank you to Martin Molin of Wintergatan for providing us the rights to use their excellent music.*****Mentioned in this episode:- Common Sense Medicine: Making America Healthy Again by Dr. Lon Jones, DO https://amzn.to/4kd4mka (commission earned)- No More Allergies, Asthma or Sinus Infections: The Revolutionary Approach by Dr. Lon Jones, DO https://amzn.to/4dKaa2o (commission earned)- George Williams Paper: Pleiotropy, Natural Selection, and the Evolution of Senescence https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1558-5646.1957.tb02911.x - Patient education: Ear infections (otitis media) in children (Beyond the Basics) https://www.uptodate.com/contents/ear-infections-otitis-media-in-children-beyond-the-basics/print - Indirect health effects of relative humidity in indoor environments https://pmc.ncbi.nlm.nih.gov/articles/PMC1474709/ - Turku sugar studies V: Final report on the effect of sucrose, fructose and xylitol diets on the caries incidence in man https://www.tandfonline.com/doi/abs/10.3109/00016357608997711 - Paul W. Ewald: Evolution of Disease https://amzn.to/4dzIzRj (commission earned)- Commonsense Medicine: Healing from the Inside Out and Stopping the Next Pandemic https://amzn.to/4kE9kX7 (commission earned)- How Bacteria Stick https://www.scientificamerican.com/article/how-bacteria-stick Support the show

Aging (Aging-US) invites #submissions for a Special Collection dedicated to the theme of cellular #senescence, spanning its basic mechanisms, physiological and pathological functions, and clinical applications. This collection is published in memory of Professor Judith Campisi, a pioneering force in the field of cellular senescence whose groundbreaking work shaped the understanding of senescence in aging, cancer, and tissue homeostasis. Her legacy continues to inspire generations of scientists working to decode the complex biology of senescent cells and their impact on health and disease. We welcome original research articles, reviews, and perspectives on topics including: -Fundamental mechanisms of senescence induction and maintenance -Regulation and context-specific roles of the senescence-associated secretory phenotype (SASP) -Beneficial and detrimental effects of senescent cells in vivo -Senescence in development, aging, regeneration, and age-related diseases -Biomarkers, imaging, and tools for senescence detection and quantification -Therapeutic targeting of senescent cells: senolytics, senomorphics, and clinical translation This Special Collection is guest edited by Han Li and Irina Conboy, both internationally recognized leaders in the study of senescence and aging. Submission Details: -Submission Deadline: January 15, 2026 -Manuscript Format: Please follow the journal's submission guidelines -Peer Review: All submissions will undergo a rigorous peer-review process -Submission Link: https://aging.msubmit.net/cgi-bin/main.plex

Is it possible to rejuvenate the immune system as we age? In this episode, Dr. Alessio Lanna breaks down the science of immune aging, focusing on the critical role of T cells, telomere shortening, and senescence. He explains how T cells lose their effectiveness over time—and shares emerging research on how intercellular telomere transfer and the ESMAC complex may help reverse immune senescence. Learn how pharmacological interventions could unlock new possibilities for health, longevity, and immune rejuvenation. Learn more about Dr. Alessio Lanna: https://sentcell.life/team/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

Broadcast from KSQD, Santa Cruz on 4-10-2025: Dr. Dawn responds to an email about difficult-to-control asthma, recommending quercetin and inhaled cromolyn as mast cell stabilizers, and suggesting Montelukast to address leukotrienes while investigating possible mold exposure as an underlying cause. She discusses groundbreaking research on age-related bone deterioration, explaining how osteocytes undergo structural changes with age, and exploring the concept of cellular senescence including potential treatments like quercetin/dasatinib combination therapy, fisetin, and metformin. A frequent caller with a history of sepsis, osteomyelitis and eye infections describes newly developed high blood pressure, with Dr. Dawn explaining how oxidative stress from infection can damage endothelial cells, reducing nitric oxide production and suggesting L-arginine, beet consumption, and proper blood pressure measurement techniques. Responding to an email about preventing cartilage loss, Dr. Dawn evaluates glucosamine sulfate research, noting key differences between effective and ineffective studies, while emphasizing the importance of achieving healthy body weight as a primary factor in preventing osteoarthritis progression. Dr. Dawn provides guidance to an email question about choosing a primary care physician before retirement, recommending selecting doctors established in their practice for 3-4 years and warning against Medicare Advantage plans that limit provider options. She addresses an email from someone experiencing persistent fatigue following Epstein-Barr virus reactivation, suggesting additional testing to confirm viral load through PCR rather than relying solely on antibody levels, while exploring alternative causes including long COVID, mold exposure, or autoimmune issues.

Broadcast from KSQD, Santa Cruz on 4-10-2025: Dr. Dawn responds to an email about difficult-to-control asthma, recommending quercetin and inhaled cromolyn as mast cell stabilizers, and suggesting Montelukast to address leukotrienes while investigating possible mold exposure as an underlying cause. She discusses groundbreaking research on age-related bone deterioration, explaining how osteocytes undergo structural changes with age, and exploring the concept of cellular senescence including potential treatments like quercetin/dasatinib combination therapy, fisetin, and metformin. A frequent caller with a history of sepsis, osteomyelitis and eye infections describes newly developed high blood pressure, with Dr. Dawn explaining how oxidative stress from infection can damage endothelial cells, reducing nitric oxide production and suggesting L-arginine, beet consumption, and proper blood pressure measurement techniques. Responding to an email about preventing cartilage loss, Dr. Dawn evaluates glucosamine sulfate research, noting key differences between effective and ineffective studies, while emphasizing the importance of achieving healthy body weight as a primary factor in preventing osteoarthritis progression. Dr. Dawn provides guidance to an email question about choosing a primary care physician before retirement, recommending selecting doctors established in their practice for 3-4 years and warning against Medicare Advantage plans that limit provider options. She addresses an email from someone experiencing persistent fatigue following Epstein-Barr virus reactivation, suggesting additional testing to confirm viral load through PCR rather than relying solely on antibody levels, while exploring alternative causes including long COVID, mold exposure, or autoimmune issues.

Christian Asare, MD, joins Integrative Practitioner Content Specialist Avery St. Onge to discuss the connection between chronic pain, aging, and cellular senescence in a live interview at the 2025 Integrative Healthcare Symposium. About the Expert Asare B. Christian, MD, MPH, is a board-certified integrative and regenerative pain management specialist and the founder of Aether Medicine in Wayne, Mainline Philadelphia. Aether Medicine focuses on cellular health to alleviate pain, enhance performance, and extend healthspan. Dr. Christian integrates various medical disciplines, including pain management, cellular medicine, neurorehabilitation, and longevity medicine, with personalized lifestyle modifications. His approach is characterized by empathetic patient care and a profound understanding of medical science, tailored to individual health solutions.

In this week's podcast on anti-aging strategies, I explore cellular senescence - what it is, how it's useful when we're young but promotes poor health when we age, and some things we can do to mitigate it.See omnystudio.com/listener for privacy information.

Visit oneskin.co/BUCK and use code BUCK at checkout for 15% off your first purchase! Dr. Carolina Reis Olivera shares her journey in aging and longevity research, highlighting the development of the OS-01 peptide—a breakthrough targeting cellular senescence to improve skin health. She delves into the biology of skin aging, the impact of senescent cells, and the cutting-edge strategies OneSkin is using to combat age-related skin conditions. The conversation also explores clinical trials, product efficacy, and the broader systemic benefits of optimizing skin health. Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/  

Today's Song of the Day is “Grin” from BAYNK's album SENESCENCE, out now.

Julieanna Hever, M.S., R.D., C.P.T., discusses strategies to optimize your healthspan. Learn how to extend your years of healthy living through diet, exercise, and lifestyle choices. #Healthspan #HealthyLiving #Longevity

In this episode of the Gladden Longevity Podcast, Dr. Mike Van Thielen shares his extensive journey in health and wellness, focusing on the benefits of molecular hydrogen. He discusses his background in physical therapy, acupuncture, and holistic nutrition, leading to his interest in longevity and anti-aging. The conversation delves into the science behind molecular hydrogen, its role as a selective antioxidant, and its adaptogenic properties. Dr. Van Thielen also explains various methods of hydrogen delivery and its applications for gut health, emphasizing the importance of balance in health interventions.    For the audience:     * Use the code 'Podcast10' to get 10% OFF your order at our supplement store → https://gladdenlongevityshop.com/   * Get Mike Van Thielen's book, the Hydrogen of your choice and access to ALL the research → https://mvtonline.com/molecular-hydrogen       Takeaways    * Molecular hydrogen is gaining recognition for its therapeutic benefits.  * Hydrogen acts as a selective antioxidant, neutralizing harmful free radicals.  * It functions as an adaptogen, helping to balance bodily functions.  * Hydrogen promotes autophagy, aiding in cellular recycling.  * Hydrogen can cross the blood-brain barrier, offering neuroprotective effects.  * It is cytoprotective, benefiting mitochondrial health and energy production.  * Hydrogen is effective for gut health, improving conditions like leaky gut.  * Different delivery methods for hydrogen can be combined for optimal results.    Chapters    00:00 Introduction to Dr. Mike Van Thielen  05:51 Journey into Health and Longevity  13:46 Exploring Molecular Hydrogen  24:56 The Science Behind Hydrogen's Benefits  30:27 Hydrogen Delivery Methods and Dosing  41:08 Hydrogen for Gut Health and Conclusion  42:59 Goodbye    To learn more about Mike, get his help, his books or contact him:  Website: https://drmike.dna.clinic/  Website: https://mvtonline.com/   Instagram: https://www.instagram.com/drmike_health4life/?hl=en   Facebook: https://www.facebook.com/drmikeinspires/    Reach out to us!     Website: https://gladdenlongevity.com/      Email: podcast@gladdenlongevity.com      Facebook: https://www.facebook.com/Gladdenlongevity/     Instagram: https://www.instagram.com/gladdenlongevity/?hl=en      LinkedIn: https://www.linkedin.com/company/gladdenlongevity     YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw 

Alex Miletich of Vile Rites & I have a conversation about his 1st beers, getting into music, discovering his voice, "Senescence" and his hangover cure. Throughout this chat, Alex drank Fogbelt Brewing's "Wet Hop IPA" while I enjoyed Sir John Brewing's "Haze Wars" which was brewed for Yakima Chief Hops presents Vox&Hops Haze Wars. This is a Heavy MTL presents Vox&Hops episode! Heavy MTL is Montreal's premier metal promoter. They host one of North America's best Metal Festivals & present countless amazing events during the rest of the year. I am truly honored & extremely excited to have them involved in the podcast. Make sure to check out Vox&Hops' Brewtal Awakenings Playlist which has been curated by the Metal Architect Jerry Monk himself on either Spotify or Apple Music. This playlist is packed with all the freshest, sickest & most extreme albums each week! Photo Credit: @cursedimages_jpg Episode Links: Website: https://www.voxandhops.com/ Join The Vox&Hops Mailing List: http://eepurl.com/hpu9F1 Join The Vox&Hops Thirsty Thursday Gang: https://www.facebook.com/groups/162615188480022 Vile Rites: https://vilerites.bandcamp.com/ Fogbelt Brewing: https://www.fogbeltbrewing.com/ Sir John Brewing: https://brasseriesirjohn.com/ Vox&Hops Brewtal Awakenings Playlist: https://www.voxandhops.com/p/brewtal-awakenings-metal-playlist/ Heavy MTL: https://heavymontreal.com/ Sound Talent Media: https://soundtalentmedia.com/  Evergreen Podcasts: https://evergreenpodcasts.com/ SUPPORT THE PODCAST: Vox&Hops Metal Podcast Merchandise: https://www.indiemerchstore.com/collections/vendors?q=Vox%26Hops Use the Promo Code: VOXHOPS10 to save 10% off your entire purchase. Pitch Black North: https://www.pitchblacknorth.com/ Use the Promo Code: VOXHOPS15 to save 15% off your entire purchase. Heartbeat Hot Sauce: https://www.heartbeathotsauce.com/ Use the Promo Code: VOXHOPS15 to save 15% off your entire purchase.

The Conversation is BACK, and in this episode, we discover the differences between over-watered and under-watered plants. Then, we have a fleeting moment of introspection and wonder if that early onset fade was really just a nutrient deficiency all along... Nah, couldn't be. So sit back, relax, grab something to smoke on and get ready for a Cultivation Conversation. Please follow the show at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@cultivation.conversation⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ and follow your hosts at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@girlgogrow⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@therealgreenmonsta⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ & ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@captainautoflower⁠⁠⁠⁠⁠⁠⁠⁠⁠.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Don't forget to like, comment, share & subscribe because all of that helps us A LOT! Thanks everyone and enjoy the show. DISCOUNT CODES AUTOPOTS - Use code "CC10" on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠autopot-usa.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ MICROBELIFEHYDRO - Use code "CCMLH15" on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://microbelifehydro.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ AC INFINITY - Use code "cultivation" on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠acinfinity.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ INSECT FRASS - Use code "CC10" ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠frassvalley.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ EVERYTHING - Use code "CC10" on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠mass-hydro.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ __________________________________________________ If you would like to support us on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Patreon https://www.patreon.com/Cultivationconversation Join us on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Discord https://discord.com/invite/xcCSBQxyYB Follow us on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Twitch https://www.twitch.tv/cultivationconversation Our ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Website  https://cultivationconversation.com/ Products We Use ⁠https://cultivationconversation.com/what-we-use/

"For every far-out idea that turns out to be true, there were probably hundreds that were simply crackpot ideas. In general, [science] advances building on the knowledge we have, and seeing what the next questions are, and then getting to the next stage and the next stage and so on. And occasionally there'll be revolutionary ideas which will really completely change your view of science. And it is possible that some revolutionary breakthrough in our understanding will come about and we might crack this problem, but there's no evidence for that. It doesn't mean that there isn't a lot of promising work going on. There are many legitimate areas which could lead to real improvements in health in old age. So I'm fairly balanced: I think there are promising areas, but there's a lot of work to be done to see which area is going to be promising, and what the risks are, and how to make them work." —Venki RamakrishnanIn today's episode, host Luisa Rodriguez speaks to Venki Ramakrishnan — molecular biologist and Nobel Prize winner — about his new book, Why We Die: The New Science of Aging and the Quest for Immortality.Links to learn more, highlights, and full transcript.They cover:What we can learn about extending human lifespan — if anything — from “immortal” aquatic animal species, cloned sheep, and the oldest people to have ever lived.Which areas of anti-ageing research seem most promising to Venki — including caloric restriction, removing senescent cells, cellular reprogramming, and Yamanaka factors — and which Venki thinks are overhyped.Why eliminating major age-related diseases might only extend average lifespan by 15 years.The social impacts of extending healthspan or lifespan in an ageing population — including the potential danger of massively increasing inequality if some people can access life-extension interventions while others can't.And plenty more.Chapters:Cold open (00:00:00)Luisa's intro (00:01:04)The interview begins (00:02:21)Reasons to explore why we age and die (00:02:35)Evolutionary pressures and animals that don't biologically age (00:06:55)Why does ageing cause us to die? (00:12:24)Is there a hard limit to the human lifespan? (00:17:11)Evolutionary tradeoffs between fitness and longevity (00:21:01)How ageing resets with every generation, and what we can learn from clones (00:23:48)Younger blood (00:31:20)Freezing cells, organs, and bodies (00:36:47)Are the goals of anti-ageing research even realistic? (00:43:44)Dementia (00:49:52)Senescence (01:01:58)Caloric restriction and metabolic pathways (01:11:45)Yamanaka factors (01:34:07)Cancer (01:47:44)Mitochondrial dysfunction (01:58:40)Population effects of extended lifespan (02:06:12)Could increased longevity increase inequality? (02:11:48)What's surprised Venki about this research (02:16:06)Luisa's outro (02:19:26)Producer: Keiran HarrisAudio engineering: Ben Cordell, Milo McGuire, Simon Monsour, and Dominic ArmstrongContent editing: Luisa Rodriguez, Katy Moore, and Keiran HarrisTranscriptions: Katy Moore