Podcasts about Senescence

  We unpack the UN Scientific Advisory Board Brief on Aging—from telomeres and epigenetic clocks

Can we really reverse biological age?  In this groundbreaking episode, I sit down with Greg Macpherson, biotechnologist, pharmacist, and founder of SRW Laboratories, to explore the cutting-edge science behind reversing biological ageing — backed by real human clinical trial data. We discuss SRW's latest clinical study, which demonstrated measurable reductions in biological age markers through targeted supplementation. Greg unpacks how biological age is assessed using epigenetic markers like DNA methylation, and how SRW's formulations are designed to influence key aging pathways including: sirtuins, NAD+ production, AMPK, and mTOR modulation. What you'll learn from the episode:  What biological age really means  How SRW's trial measured age reversal using TruDiagnostic epigenetic clocks  Key molecules and compounds driving the effect  The importance of cellular senescence, mitochondrial function, and genomic stability  What's next in the field of longevity biotechnology Whether you're a health professional, biohacker, or longevity enthusiast, this episode is packed with science-forward insights and actionable takeaways. Shop SRW supplements here: SRW Supplement Range  Follow Greg Macpherson: Linkedin/Greg Nacpherson SRW  Explore epigenetic testing: Trudiagnostic - TruAge COMPLETE Greg Macpherson: Throughout my career, I have been driven by a desire to help people achieve their potential by overcoming health challenges. As a biotechnologist, futurist, author, and pharmacologist, I have pursued this goal by founding one of the first online pharmacies in New Zealand and creating the country's first Government licensed robotic dispensing facility. My current focus is on understanding cellular aging and developing new formulations to support healthy aging and improve human health. For the past 10 years, I have been researching cellular aging and consulting with global experts in the field. All of this research and experience has led me to establish SRW, an organization that aims to translate scientific advancements into practical solutions for everyday people to live longer, healthier lives.  

Merlyn Silva - Field Trip (Original Mix) Senescence - Sofa Beats SOFABEATS159 1. Merlyn Silva - Field Trip (Original Mix) 2. Merlyn Silva - Meandering 3. Merlyn Silva - Falls Upwards (Original Mix) 4. Merlyn Silva - Unlearning (Original Mix) 5. Merlyn Silva - Red Sky Thinking (Original Mix) 6. Merlyn Silva - Ecocentrism 7. Merlyn Silva - The Swing That Swung (Original Mix) 8. Merlyn Silva - Senescence (Original Mix) Merlyn Silva returns with his fourth album Senescence; a kaleidoscopic ode to the gentle passage of time. Wandering between transcendent downtempo journeys and wiggly dancefloor mischief, Senescence is a refinement of Merlyn's leftfield take on psychedelic electronic music. From the euphoric downtempo of "Unlearning" to the mooching grooves of "Meandering", Senescence creates a space where acousmatic field recordings can drink chai and high-five with contemporary synth workouts and dank midtempo beats. As the album evolves it's hard not to notice the parallel to the dramatic seasons of Northern Europe, staring lighthearted and optimistic before culminating in the introspective deepness of title track.

Bret speaks with Dr. Lon Jones, DO on the subject of the mismatch between modern humans and the environment they live in. Find Dr. Lon Jones, DO at https://commonsensemedicine.org*****Join DarkHorse on Locals! Get access to our Discord server, exclusive live streams, live chats for all streams, and early access to many podcasts: https://darkhorse.locals.comCheck out the DHP store! Epic tabby, digital book burning, saddle up the dire wolves, and more: https://www.darkhorsestore.orgTheme Music: Thank you to Martin Molin of Wintergatan for providing us the rights to use their excellent music.*****Mentioned in this episode:- Common Sense Medicine: Making America Healthy Again by Dr. Lon Jones, DO https://amzn.to/4kd4mka (commission earned)- No More Allergies, Asthma or Sinus Infections: The Revolutionary Approach by Dr. Lon Jones, DO https://amzn.to/4dKaa2o (commission earned)- George Williams Paper: Pleiotropy, Natural Selection, and the Evolution of Senescence https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1558-5646.1957.tb02911.x - Patient education: Ear infections (otitis media) in children (Beyond the Basics) https://www.uptodate.com/contents/ear-infections-otitis-media-in-children-beyond-the-basics/print - Indirect health effects of relative humidity in indoor environments https://pmc.ncbi.nlm.nih.gov/articles/PMC1474709/ - Turku sugar studies V: Final report on the effect of sucrose, fructose and xylitol diets on the caries incidence in man https://www.tandfonline.com/doi/abs/10.3109/00016357608997711 - Paul W. Ewald: Evolution of Disease https://amzn.to/4dzIzRj (commission earned)- Commonsense Medicine: Healing from the Inside Out and Stopping the Next Pandemic https://amzn.to/4kE9kX7 (commission earned)- How Bacteria Stick https://www.scientificamerican.com/article/how-bacteria-stick Support the show

Aging (Aging-US) invites #submissions for a Special Collection dedicated to the theme of cellular #senescence, spanning its basic mechanisms, physiological and pathological functions, and clinical applications. This collection is published in memory of Professor Judith Campisi, a pioneering force in the field of cellular senescence whose groundbreaking work shaped the understanding of senescence in aging, cancer, and tissue homeostasis. Her legacy continues to inspire generations of scientists working to decode the complex biology of senescent cells and their impact on health and disease. We welcome original research articles, reviews, and perspectives on topics including: -Fundamental mechanisms of senescence induction and maintenance -Regulation and context-specific roles of the senescence-associated secretory phenotype (SASP) -Beneficial and detrimental effects of senescent cells in vivo -Senescence in development, aging, regeneration, and age-related diseases -Biomarkers, imaging, and tools for senescence detection and quantification -Therapeutic targeting of senescent cells: senolytics, senomorphics, and clinical translation This Special Collection is guest edited by Han Li and Irina Conboy, both internationally recognized leaders in the study of senescence and aging. Submission Details: -Submission Deadline: January 15, 2026 -Manuscript Format: Please follow the journal's submission guidelines -Peer Review: All submissions will undergo a rigorous peer-review process -Submission Link: https://aging.msubmit.net/cgi-bin/main.plex

Is it possible to rejuvenate the immune system as we age? In this episode, Dr. Alessio Lanna breaks down the science of immune aging, focusing on the critical role of T cells, telomere shortening, and senescence. He explains how T cells lose their effectiveness over time—and shares emerging research on how intercellular telomere transfer and the ESMAC complex may help reverse immune senescence. Learn how pharmacological interventions could unlock new possibilities for health, longevity, and immune rejuvenation. Learn more about Dr. Alessio Lanna: https://sentcell.life/team/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

Broadcast from KSQD, Santa Cruz on 4-10-2025: Dr. Dawn responds to an email about difficult-to-control asthma, recommending quercetin and inhaled cromolyn as mast cell stabilizers, and suggesting Montelukast to address leukotrienes while investigating possible mold exposure as an underlying cause. She discusses groundbreaking research on age-related bone deterioration, explaining how osteocytes undergo structural changes with age, and exploring the concept of cellular senescence including potential treatments like quercetin/dasatinib combination therapy, fisetin, and metformin. A frequent caller with a history of sepsis, osteomyelitis and eye infections describes newly developed high blood pressure, with Dr. Dawn explaining how oxidative stress from infection can damage endothelial cells, reducing nitric oxide production and suggesting L-arginine, beet consumption, and proper blood pressure measurement techniques. Responding to an email about preventing cartilage loss, Dr. Dawn evaluates glucosamine sulfate research, noting key differences between effective and ineffective studies, while emphasizing the importance of achieving healthy body weight as a primary factor in preventing osteoarthritis progression. Dr. Dawn provides guidance to an email question about choosing a primary care physician before retirement, recommending selecting doctors established in their practice for 3-4 years and warning against Medicare Advantage plans that limit provider options. She addresses an email from someone experiencing persistent fatigue following Epstein-Barr virus reactivation, suggesting additional testing to confirm viral load through PCR rather than relying solely on antibody levels, while exploring alternative causes including long COVID, mold exposure, or autoimmune issues.

Christian Asare, MD, joins Integrative Practitioner Content Specialist Avery St. Onge to discuss the connection between chronic pain, aging, and cellular senescence in a live interview at the 2025 Integrative Healthcare Symposium. About the Expert Asare B. Christian, MD, MPH, is a board-certified integrative and regenerative pain management specialist and the founder of Aether Medicine in Wayne, Mainline Philadelphia. Aether Medicine focuses on cellular health to alleviate pain, enhance performance, and extend healthspan. Dr. Christian integrates various medical disciplines, including pain management, cellular medicine, neurorehabilitation, and longevity medicine, with personalized lifestyle modifications. His approach is characterized by empathetic patient care and a profound understanding of medical science, tailored to individual health solutions.

In this week's podcast on anti-aging strategies, I explore cellular senescence - what it is, how it's useful when we're young but promotes poor health when we age, and some things we can do to mitigate it.See omnystudio.com/listener for privacy information.

Visit oneskin.co/BUCK and use code BUCK at checkout for 15% off your first purchase! Dr. Carolina Reis Olivera shares her journey in aging and longevity research, highlighting the development of the OS-01 peptide—a breakthrough targeting cellular senescence to improve skin health. She delves into the biology of skin aging, the impact of senescent cells, and the cutting-edge strategies OneSkin is using to combat age-related skin conditions. The conversation also explores clinical trials, product efficacy, and the broader systemic benefits of optimizing skin health. Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/  

Today's Song of the Day is “Grin” from BAYNK's album SENESCENCE, out now.

Julieanna Hever, M.S., R.D., C.P.T., discusses strategies to optimize your healthspan. Learn how to extend your years of healthy living through diet, exercise, and lifestyle choices. #Healthspan #HealthyLiving #Longevity

In this episode of the Gladden Longevity Podcast, Dr. Mike Van Thielen shares his extensive journey in health and wellness, focusing on the benefits of molecular hydrogen. He discusses his background in physical therapy, acupuncture, and holistic nutrition, leading to his interest in longevity and anti-aging. The conversation delves into the science behind molecular hydrogen, its role as a selective antioxidant, and its adaptogenic properties. Dr. Van Thielen also explains various methods of hydrogen delivery and its applications for gut health, emphasizing the importance of balance in health interventions.    For the audience:     * Use the code 'Podcast10' to get 10% OFF your order at our supplement store → https://gladdenlongevityshop.com/   * Get Mike Van Thielen's book, the Hydrogen of your choice and access to ALL the research → https://mvtonline.com/molecular-hydrogen       Takeaways    * Molecular hydrogen is gaining recognition for its therapeutic benefits.  * Hydrogen acts as a selective antioxidant, neutralizing harmful free radicals.  * It functions as an adaptogen, helping to balance bodily functions.  * Hydrogen promotes autophagy, aiding in cellular recycling.  * Hydrogen can cross the blood-brain barrier, offering neuroprotective effects.  * It is cytoprotective, benefiting mitochondrial health and energy production.  * Hydrogen is effective for gut health, improving conditions like leaky gut.  * Different delivery methods for hydrogen can be combined for optimal results.    Chapters    00:00 Introduction to Dr. Mike Van Thielen  05:51 Journey into Health and Longevity  13:46 Exploring Molecular Hydrogen  24:56 The Science Behind Hydrogen's Benefits  30:27 Hydrogen Delivery Methods and Dosing  41:08 Hydrogen for Gut Health and Conclusion  42:59 Goodbye    To learn more about Mike, get his help, his books or contact him:  Website: https://drmike.dna.clinic/  Website: https://mvtonline.com/   Instagram: https://www.instagram.com/drmike_health4life/?hl=en   Facebook: https://www.facebook.com/drmikeinspires/    Reach out to us!     Website: https://gladdenlongevity.com/      Email: podcast@gladdenlongevity.com      Facebook: https://www.facebook.com/Gladdenlongevity/     Instagram: https://www.instagram.com/gladdenlongevity/?hl=en      LinkedIn: https://www.linkedin.com/company/gladdenlongevity     YouTube: https://www.youtube.com/channel/UC5_q8nexY4K5ilgFnKm7naw 

BUFFALO, NY- December 10, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 21 on November 18, 2024, entitled, “Prostaglandin E2 regulates senescence and post-senescence neoplastic escape in primary human keratinocytes.” Researchers Elise Srour, Nathalie Martin, Claire Drullion, Clémentine De Schutter, Joëlle Giroud, Adrien Pioger, Julie Deslé, Laure Saas, Joe Nassour, Julien Théry, Gauthier Decanter, Nicolas Penel, Chantal Vercamer, Clara Salazar-Cardozo, Corinne Abbadie, and Olivier Pluquet from CNRS, University of Lille, the Oscar Lambret Center, and the University of Colorado School of Medicine have revealed how a molecule called Prostaglandin E2 (PGE2) influences skin aging and cancer risk. Their study shows that PGE2 not only drives skin cells to age but also enables some of these aging cells to bypass natural limits and develop into pre-cancerous cells. This process provides insights into why older skin is more susceptible to cancer. The study focused on keratinocytes, the primary cells in the outer layer of the skin. As these cells age, they enter a state called senescence, where they stop dividing to prevent damaged cells from turning cancerous. While this process typically serves as a protective mechanism, the researchers found that, in certain cases, some senescent cells can escape this state, re-enter the cell cycle, and acquire characteristics of early cancer. By examining keratinocytes from donors of different ethnicities and ages, the researchers identified the PTGS2/PGE2/EP4 pathway as a key driver of this escape process. The researchers show that blocking PGE2 or its associated pathway reduced the chances of aged cells becoming precancerous. This suggests that drugs targeting this pathway, including some anti-inflammatory medications already in use, might be repurposed to slow skin aging and prevent early-stage skin cancers. Additionally, the study also found that PGE2 levels increase in the skin as it ages, further supporting its role in skin health and disease. "These results indicate that the PTGS2/PGE2/EP4 pathway is required to induce and maintain the senescent phenotype of NHEKs, and that PGE2 level is a potential determinant of the initial steps of the age-related oncogenic process." The team also highlighted the broader implications of their work. The PTGS2/PGE2/EP4 pathway is not only linked to skin health but also to age-related inflammation, a condition that contributes to several diseases. By addressing this pathway, researchers hope to address not only skin aging but other health challenges linked to aging and chronic inflammation. In conclusion, this study reveals important molecular drivers of skin aging and early cancer, leading the way for new approaches that can promote healthier skin. DOI - https://doi.org/10.18632/aging.206149 Corresponding author - Olivier Pluquet - olivier.pluquet@ibl.cnrs.fr Video short - https://www.youtube.com/watch?v=4aNf3X2RJSw About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Alex Miletich of Vile Rites & I have a conversation about his 1st beers, getting into music, discovering his voice, "Senescence" and his hangover cure. Throughout this chat, Alex drank Fogbelt Brewing's "Wet Hop IPA" while I enjoyed Sir John Brewing's "Haze Wars" which was brewed for Yakima Chief Hops presents Vox&Hops Haze Wars. This is a Heavy MTL presents Vox&Hops episode! Heavy MTL is Montreal's premier metal promoter. They host one of North America's best Metal Festivals & present countless amazing events during the rest of the year. I am truly honored & extremely excited to have them involved in the podcast. Make sure to check out Vox&Hops' Brewtal Awakenings Playlist which has been curated by the Metal Architect Jerry Monk himself on either Spotify or Apple Music. This playlist is packed with all the freshest, sickest & most extreme albums each week! Photo Credit: @cursedimages_jpg Episode Links: Website: https://www.voxandhops.com/ Join The Vox&Hops Mailing List: http://eepurl.com/hpu9F1 Join The Vox&Hops Thirsty Thursday Gang: https://www.facebook.com/groups/162615188480022 Vile Rites: https://vilerites.bandcamp.com/ Fogbelt Brewing: https://www.fogbeltbrewing.com/ Sir John Brewing: https://brasseriesirjohn.com/ Vox&Hops Brewtal Awakenings Playlist: https://www.voxandhops.com/p/brewtal-awakenings-metal-playlist/ Heavy MTL: https://heavymontreal.com/ Sound Talent Media: https://soundtalentmedia.com/  Evergreen Podcasts: https://evergreenpodcasts.com/ SUPPORT THE PODCAST: Vox&Hops Metal Podcast Merchandise: https://www.indiemerchstore.com/collections/vendors?q=Vox%26Hops Use the Promo Code: VOXHOPS10 to save 10% off your entire purchase. Pitch Black North: https://www.pitchblacknorth.com/ Use the Promo Code: VOXHOPS15 to save 15% off your entire purchase. Heartbeat Hot Sauce: https://www.heartbeathotsauce.com/ Use the Promo Code: VOXHOPS15 to save 15% off your entire purchase.

The Conversation is BACK, and in this episode, we discover the differences between over-watered and under-watered plants. Then, we have a fleeting moment of introspection and wonder if that early onset fade was really just a nutrient deficiency all along... Nah, couldn't be. So sit back, relax, grab something to smoke on and get ready for a Cultivation Conversation. Please follow the show at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@cultivation.conversation⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ and follow your hosts at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@girlgogrow⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@therealgreenmonsta⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ & ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@captainautoflower⁠⁠⁠⁠⁠⁠⁠⁠⁠.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Don't forget to like, comment, share & subscribe because all of that helps us A LOT! Thanks everyone and enjoy the show. DISCOUNT CODES AUTOPOTS - Use code "CC10" on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠autopot-usa.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ MICROBELIFEHYDRO - Use code "CCMLH15" on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://microbelifehydro.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ AC INFINITY - Use code "cultivation" on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠acinfinity.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ INSECT FRASS - Use code "CC10" ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠frassvalley.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ EVERYTHING - Use code "CC10" on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠mass-hydro.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ __________________________________________________ If you would like to support us on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Patreon https://www.patreon.com/Cultivationconversation Join us on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Discord https://discord.com/invite/xcCSBQxyYB Follow us on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Twitch https://www.twitch.tv/cultivationconversation Our ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Website  https://cultivationconversation.com/ Products We Use ⁠https://cultivationconversation.com/what-we-use/

Our guest today is the brilliant BAYNK, an electronic artist who hails from New Zealand but now lives in LA. Known for his unique blend of lush, feel-good beats with introspective lyrics, BAYNK first made waves with his 2022 debut album, Adolescence, which earned him a Grammy nomination. His latest release, Senescence, dives deeper—exploring themes of human fragility and the passage of time, all while maintaining his signature sonic warmth. In today's episode, we talk to BAYNK about the inspiration behind Senescence and how he approaches pairing light, danceable sounds with weightier subject matter. We also get into the pressures of following up a celebrated debut, and how being the creative director of his project allows him to seamlessly integrate visual storytelling into his music.BAYNK: Instagram / Spotify Visit our official website here and follow us across our socials.

References Mech Ageing Dev.2021 Dec:200:111595. Open Biol. 2021 Dec; 11(12): 210110. Mol Metab.2023 Jan; 67: 101652 Genes Dis 2023 Nov 27;11(6):101180 Grisman, D. 1975 "Old and in the Way" https://open.spotify.com/track/1vao1Gy21m3KwPMgTbfhrG?si=4e3843aa556341b7 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

In this episode of Healthy AF (Healthy After 50), Zane Griggs interviews Dr. Greg Kelly, a leading expert on aging and cellular health, to discuss a critical concept: cellular senescence. This scientific term may hold the key to longevity, muscle retention, and vitality as we age. What is Cellular Senescence? Dr. Kelly explains cellular senescence as a biological process where aging cells stop dividing but don't die off. Instead, they linger in the body, contributing to inflammation and accelerating the aging process. These “zombie cells” can disrupt the function of healthy cells and tissues, playing a role in age-related diseases. The Impact on Longevity and Muscle Health For individuals over 50 focused on muscle building, cellular senescence can be a hidden roadblock. Dr. Kelly highlights how managing these senescent cells can help optimize physical performance and recovery. Zane and Dr. Kelly discuss ways to target these aging cells to enhance longevity, preserve muscle, and maintain high performance. Nutritional and Supplement Strategies The conversation dives into cutting-edge nutritional and supplement strategies to combat cellular senescence. Dr. Kelly shares the latest research on compounds like quercetin and fisetin, which have shown promise in reducing senescent cells and promoting overall cellular health. These insights offer practical solutions for anyone looking to slow the effects of aging. The Role of Lifestyle in Cellular Health Beyond supplements, lifestyle choices play a critical role in managing cellular senescence. Dr. Kelly emphasizes the importance of regular exercise, stress management, and proper sleep to support the body's ability to clear out senescent cells. Zane adds his perspective on how building muscle and staying active can significantly influence cellular health and longevity. Final Thoughts In this episode, Zane Griggs and Dr. Greg Kelly explore the science behind cellular senescence and provide actionable insights into how we can slow the aging process, retain muscle, and maintain peak performance. Whether through targeted supplements or lifestyle adjustments, understanding cellular health is key to living a longer, healthier life after 50. Listen to the Full Episode Hit play to hear the conversation on Healthy AF (Healthy After 50) to discover more about the fascinating world of cellular senescence and longevity.   Connect with Zane:  Follow me on Instagram: https://www.instagram.com/zanegriggsfitness Website: https://zanegriggs.com ReLyte Electrolytes by Redmond Real Salt: https://shop.redmond.life?afmc=Zane   Quick Episode Summary:  0:00 Introduction: Zane introduces Dr. Greg Kelly and the topic of cellular senescence. 2:10 What Is Cellular Senescence? Dr. Kelly explains the science behind aging cells. 6:00 How Senescent Cells Impact Aging: The effects of these "zombie cells" on health and longevity. 10:45 Key Nutrients to Combat Senescence: The role of quercetin, fisetin, and other supplements. 15:30 Muscle Health and Senescence: Zane and Dr. Kelly discuss muscle recovery and aging. 20:50 Mitochondrial Function and Longevity: How maintaining energy production is key. 27:15 Lifestyle Choices to Support Cellular Health: Exercise, diet, and habits to slow aging. 32:40 Stress Management: The link between chronic stress and cellular aging. 37:30 Supplements for Longevity: Dr. Kelly shares top supplements to support brain and body health. 43:15 Practical Tips: How to start implementing anti-aging strategies today. 49:00 Final Thoughts: Zane and Dr. Kelly recap the importance of cellular health and longevity.

"For every far-out idea that turns out to be true, there were probably hundreds that were simply crackpot ideas. In general, [science] advances building on the knowledge we have, and seeing what the next questions are, and then getting to the next stage and the next stage and so on. And occasionally there'll be revolutionary ideas which will really completely change your view of science. And it is possible that some revolutionary breakthrough in our understanding will come about and we might crack this problem, but there's no evidence for that. It doesn't mean that there isn't a lot of promising work going on. There are many legitimate areas which could lead to real improvements in health in old age. So I'm fairly balanced: I think there are promising areas, but there's a lot of work to be done to see which area is going to be promising, and what the risks are, and how to make them work." —Venki RamakrishnanIn today's episode, host Luisa Rodriguez speaks to Venki Ramakrishnan — molecular biologist and Nobel Prize winner — about his new book, Why We Die: The New Science of Aging and the Quest for Immortality.Links to learn more, highlights, and full transcript.They cover:What we can learn about extending human lifespan — if anything — from “immortal” aquatic animal species, cloned sheep, and the oldest people to have ever lived.Which areas of anti-ageing research seem most promising to Venki — including caloric restriction, removing senescent cells, cellular reprogramming, and Yamanaka factors — and which Venki thinks are overhyped.Why eliminating major age-related diseases might only extend average lifespan by 15 years.The social impacts of extending healthspan or lifespan in an ageing population — including the potential danger of massively increasing inequality if some people can access life-extension interventions while others can't.And plenty more.Chapters:Cold open (00:00:00)Luisa's intro (00:01:04)The interview begins (00:02:21)Reasons to explore why we age and die (00:02:35)Evolutionary pressures and animals that don't biologically age (00:06:55)Why does ageing cause us to die? (00:12:24)Is there a hard limit to the human lifespan? (00:17:11)Evolutionary tradeoffs between fitness and longevity (00:21:01)How ageing resets with every generation, and what we can learn from clones (00:23:48)Younger blood (00:31:20)Freezing cells, organs, and bodies (00:36:47)Are the goals of anti-ageing research even realistic? (00:43:44)Dementia (00:49:52)Senescence (01:01:58)Caloric restriction and metabolic pathways (01:11:45)Yamanaka factors (01:34:07)Cancer (01:47:44)Mitochondrial dysfunction (01:58:40)Population effects of extended lifespan (02:06:12)Could increased longevity increase inequality? (02:11:48)What's surprised Venki about this research (02:16:06)Luisa's outro (02:19:26)Producer: Keiran HarrisAudio engineering: Ben Cordell, Milo McGuire, Simon Monsour, and Dominic ArmstrongContent editing: Luisa Rodriguez, Katy Moore, and Keiran HarrisTranscriptions: Katy Moore

Send us a textAbout the guest: Austin Argentieri, PhD is a researcher in the Analytic & Translational Genetics Unit at the Massachusetts General Hospital with academic appointments at Harvard & the Broad Institute. His research focuses on large-scale analyses to to understand human aging.Episode summary: Nick and Dr. Argentieri discuss: chronological vs. biological age; DNA methylation and aging clocks; proteomics and protein measurements in aging research; health, longevity, and human healthspan; and more.Related episodes:Aging, mTOR, Sirtuins, Rapamycin, Metformin, the Truth of Resveratrol & Longevity Supplements, David Sinclair & Anti-Aging Myths | Matt Kaeberlein | #151Cellular Aging, Taurine, Nutrition, Senescence, Longevity, Mitochondria, Metabolism | Vijay Yadav | #122*This content is never meant to serve as medical advice.Support the Show.All episodes (audio & video), show notes, transcripts, and more at the M&M Substack Try Athletic Greens: Comprehensive & convenient daily nutrition. Free 1-year supply of vitamin D with purchase.Try SiPhox Health—Affordable, at-home bloodwork w/ a comprehensive set of key health marker. Use code TRIKOMES for a 10% discount.Try the Lumen device to optimize your metabolism for weight loss or athletic performance. Use code MIND for 10% off.Learn all the ways you can support my efforts

Izzy guest co-hosts this conversation with Dr. Chris Jones about Big Ag dominating our state's population, politics, and environment. Read Chris's posts: https://riverraccoon.substack.com Call us at (319) 849-8733! Closing music by Show Me The Body: https://showmethebody.bandcamp.com Full episode notes here: https://www.patreon.com/posts/111018645 https://rockhardcauc.us

BUFFALO, NY- August 13, 2024 – A new #research perspective was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 14 on July 19, 2024, entitled, “Lipid accumulation drives cellular senescence in dopaminergic neurons.” As highlighted in the Abstract of this perspective, Parkinson's disease (PD) is an age-related movement disorder caused by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) of the midbrain. However, the underlying causes of this DA neuron loss in PD are unknown, and there are currently no effective treatments to prevent or slow neuronal loss or the progression of related symptoms. In their perspective, researchers Taylor Russo and Markus Riessland from Stony Brook University found that artificially inducing GluCer accumulation leads to cellular senescence of DA neurons. This suggests that lipid aggregation plays a crucial role in the pathology of PD by driving senescence in these vulnerable neurons. “Here, we discuss the relevance of the age-related aggregation of lipids as well as the direct functional link between general lipid aggregation, cellular senescence, and inflammaging of DA neurons.” Additionally, they propose that the expression of a cellular senescence phenotype in the most vulnerable neurons in PD can be triggered by lysosomal impairment and lipid aggregation. “Importantly, we highlight additional data that perilipin (PLIN2) is significantly upregulated in senescent DA neurons, suggesting an overall enrichment of lipid droplets (LDs) in these cells.” DOI - https://doi.org/10.18632/aging.206030 Corresponding author - Markus Riessland - markus.riessland@stonybrook.edu Video short - https://www.youtube.com/watch?v=CsBthdwpdGg Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206030 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, lipids, cellular senescence, Parkinson's disease, glucosylceramides, lysosomes, neuroinflammation About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Today's episode is audio from a Members Only QnA Stream we do for GrowCast Members every other weekend! We sit down for GCTV once a week, and a QnA every other week- to make SURE that GrowCast Members get ALL their grow questions answered, and get ALL the help they need! Today's QnA covers things like end of harvest flush, and determining when your plant is senescing versus when your plant is just hungry in late flower. We also talk to a home grower who is working with small pots and using bottled nutrients- this leads to a conversation about runoff and how critical it is to understand runoff whether you're running bottled nutrients or soil. We cover a whole host of other Member Questions and give some updates to our members as well- if you want to catch EVERY QnA and EVERY GCTV check out GrowCast Membership today!!! GrowCast Membership Weekly Live Streams - Personal Garden Advice- 100s of HOURS of Bonus Content  - MEMBERS ONLY DISCOUNTS! Join the greatest community in cannabis! GrowCast Seed Co VAULTED PACKS ARE UP! Members get $20 off PER PACK! Code growcast15 now works with grow KITS from AC Infinity! www.acinfinity.com use promo code growcast15 for 10% off the BEST grow fans in the game, plus tents, pots, scissors, LED lights, and now REFILLABLE FILTERS!

Over the human lifespan, our cells encounter numerous stressors that can trigger an intrinsic defense mechanism called cellular senescence. Cellular senescence is characterized by irreversible growth arrest and can act as a safeguard against cancer. However, when senescent cells accumulate in various tissues as we age, it can contribute to tissue degeneration and chronic diseases. The senescence-associated secretory phenotype (SASP), a hallmark of senescent cells, plays a critical role by secreting inflammatory factors, proteases, and growth factors, disrupting tissue balance and fueling pathological conditions. Consequently, selectively eliminating senescent cells has emerged as a promising therapeutic strategy, potentially restoring tissue function and mitigating age-related disorders. Full blog - https://aging-us.org/2024/07/links-between-exercise-senescence-and-lung-health/ Research Paper DOI - https://doi.org/10.18632/aging.205976 Corresponding author - Masataka Sugimoto - msugimot@tmig.or.jp Video short - https://www.youtube.com/watch?v=Bzgb2PEiV9c Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205976 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, senescence, exercise, PEDF, myokine, COPD About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

BUFFALO, NY- July 15, 2024 – A new #research paper was #published on the #cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 13, entitled, “Roles of pigment epithelium-derived factor in exercise-induced suppression of senescence and its impact on lung pathology in mice.” Senescent cells contribute to tissue aging and underlie the pathology of chronic diseases. The benefits of eliminating senescent cells have been demonstrated in several disease models, and the efficacy of senolytic drugs is currently being tested in humans. Exercise training has been shown to reduce cellular senescence in several tissues; however, the mechanisms responsible remain unclear. In this new study, researchers Hiromichi Tsushima, Hirobumi Tada, Azusa Asai, Mikako Hirose, Tohru Hosoyama, Atsushi Watanabe, Taro Murakami, and Masataka Sugimoto from Tokyo Metropolitan Institute for Geriatrics and Gerontology, Shigakkan University, and National Center for Geriatrics and Gerontology investigated myocyte-secreted factors with the potential to suppress cellular senescence, aiming to explore their protective effects against lung disease. “We found that myocyte-derived factors significantly extended the replicative lifespan of fibroblasts, suggesting that myokines mediate the anti-senescence effects of exercise.” A number of proteins within myocyte-derived factors were identified by mass spectrometry. Among these, pigment epithelium-derived factor (PEDF) exerted inhibitory effects on cellular senescence. Eight weeks of voluntary running increased PEDF levels in skeletal muscles and suppressed senescence markers in the lungs. The administration of PEDF reduced senescence markers in multiple tissues and attenuated the decline in respiratory function in the pulmonary emphysema mouse model. The researchers also showed that blood levels of PEDF inversely correlated with the severity of COPD in patients. “Collectively, these results strongly suggest that PEDF contributes to the beneficial effects of exercise, potentially suppressing cellular senescence and its associated pathologies.” DOI - https://doi.org/10.18632/aging.205976 Corresponding authors - Masataka Sugimoto - msugimot@tmig.or.jp Video short - https://www.youtube.com/watch?v=Bzgb2PEiV9c Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205976 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, senescence, exercise, PEDF, myokine, COPD About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

References Circ Res. 2018 Sep 14; 123(7): 868–885 Ungurianu, A., Manuela Drăgoi, C.,Crenguța,Nicolae, A., Dumitrescu,I.-B., Grădinaru, D.,& Margină, D.2024. IntechOpen. doi: 10.5772/intechopen.1003914 Blood Cancer J. 2024 Dec; 14(1): 24 --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

Subscribe to our channel: https://www.youtube.com/@optispan Check out the Gurkar lab: http://agresearchlab.com/ In May 2024, Matt delivered a talk at the 2024 Glenn AFAR Grantee Conference in Santa Barbara, California and met with several people doing interesting work in the longevity field. One of these was Aditi Gurkar, an assistant professor in the University of Pittsburgh's Aging Institute, Division of Geriatric Medicine whose lab focuses on the downstream effects of DNA damage on aging. Prior to setting up her lab at the University of Pittsburgh, Aditi conducted research on the impact of DNA damage on aging at Scripps Research. She also completed postdoctoral training at Massachusetts General Hospital/Harvard Medical School and the Broad Institute of MIT and Harvard, where she focused on the tumor suppressor p53 as well as on autophagy regulation. Aditi received a PhD and a B.S. from the Boston University School of Medicine and Florida International University in Miami respectively. Matt and Aditi spend much of this episode chatting about senescent cells: how Aditi developed a focus on cellular senescence and found its relevance to aging, potential therapeutic benefits of senescent cell clearance, and the much-debated question of how to define a senescent cell. They also discuss the importance of "zooming out" from narrow areas of focus in the geroscience field to find new solutions and of breaking your own models on your way to productive new directions in science. Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

I'm thrilled to be joined by Dr. Alessandra Zonari to take a deep dive into a breakthrough in skincare science that has caught my attention—OneSkin's OS-01 peptide. This episode explores how OS-01 targets cellular senescence, the core of aging, potentially transforming skin health - preserving function, not just aesthetics. I'm particularly impressed by OneSkin's commitment to rigorous research and evidence-based results. Their approach rejuvenates skin function in addition to enhancing its natural radiance, elasticity, and even its microbiome. This could be a significant advancement for individuals managing aging skin or conditions like atopic dermatitis. Throughout our discussion, we explore the scientific foundation behind OS-01 and its clinical implications and uncover how this peptide may redefine skincare protocols, offering new possibilities for healthier, more radiant skin. Whether you're a practitioner seeking innovative solutions for patients for ultrasensitive skin or dermatitis, or someone passionate about maintaining skin health, this episode promises insights that could reshape your approach to skincare. And if you're using OneSkin, I'd be curious to hear from you. You can post a comment wherever you're listening to this or email me directly at DrKaraFitzgerald.com. ~DrKF Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for the full list of links and resources. GUEST DETAILS Alessandra Zonari, PhD OneSkin co-founder and Chief Scientific Officer, Alessandra Zonari, PhD joined the early team in 2017 dedicating her time to understanding the underlying mechanism of the aging process and developing solutions to reverse skin's biological age. Zonari is the co-inventor of five patents and has published more than 20 peer-reviewed papers in scientific journals. Email: alessandra@oneskin.co THANKS TO OUR SPONSOR OneSkin: Website PROMO Try OneSkin for yourself with coupon code DRKARA15 to receive 15% off your first purchase at Website SHOW NOTES Animated science video explaining how OS-01 works Another Study Website Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models Study Website In vitro and in vivo toxicity assessment of the senotherapeutic Peptide 14 Study Website Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging Another Study Website MolClock: Estimate DNA methylation age of Skin Tissues Study Website Double-blind, vehicle-controlled clinical investigation of peptide OS-01 for skin rejuvenation Another Study Website Senotherapeutics, Senolytics, and Senomorphics -- What are they and what is OS-01? Study Website

Today we are recapping the 2003 classic: Freaky Friday starring Jamie Lee Curtis and Lindsay Lohan. Senescence was truly in retrograde as we recorded this episode!

BUFFALO, NY- May 22, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 9, entitled, “Cell type-dependent modulation of senescence features using Weo electrolyzed water.” Electrolyzed-reduced water has powerful antioxidant properties with constituents that scavenge reactive oxygen species (ROS), which are known to be produced by several intrinsic and extrinsic processes. When there is an imbalance between ROS production and antioxidant defenses, oxidative stress occurs. Persistent oxidative stress leads to cellular senescence, an important hallmark of aging, and is involved in several age-related conditions and illnesses. In this new study, researchers Brenda L. Court-Vazquez, Shirley A. Arroyo-Vizcarrondo, Jonathan A. Poli, Lara Nyman, Kelly Halderman, Anthony Ginter, and Pierre-Yves Desprez from Weo LLC and California Pacific Medical Center investigated whether Weo electrolyzed water (WEW) could modulate the phenotype of senescent cells. “The focus of this study was to utilize two different cell types, human normal fibroblasts and human breast cancer cells, to investigate the impact of Weo electrolyzed water (WEW) on markers of cellular senescence, inflammation, and stress response genes.” The researchers compared normal human lung fibroblasts (BJ) and breast cancer cells (T47D) treated with hydrogen peroxide (H2O2) to induce senescence. They assessed the molecular impact of WEW on markers of cellular senescence, senescence-associated secretory phenotype (SASP) factors, and stress response genes. Treatment with WEW modulated markers of cellular senescence, such as the senescence-associated β-galactosidase (SA-β-gal) activity, EdU incorporation and p21 expression, similarly in both cell types. However, WEW modulated the expression of SASP factors and stress response genes in a cell type-dependent and opposite fashion, significantly decreasing them in BJ cells, while stimulating their expression in T47D cells. Reduction in the expression of SASP factors and stress-related genes in BJ cells suggests that WEW acts as a protective factor, thereby reducing oxidative stress in normal cells, while making cancer cells more sensitive to the effects of cellular stress, thus increasing their elimination and consequently reducing their deleterious effects. “In conclusion, we have shown here that the new technology developed by Weo, WEW, could attenuate the overall process of cellular senescence in both normal BJ fibroblasts and cancer T47D cells.” DOI - https://doi.org/10.18632/aging.205789 Corresponding authors - Brenda L. Court-Vazquez - bco@we-o.com, and Pierre-Yves Desprez - pydesprez@cpmcri.org Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, cellular senescence, senescence-associated secretory phenotype, oxidative stress, lung fibroblasts, breast cancer cells, senomorphic About Aging-US Aging publishes research papers in all fields of aging research, including but not limited to aging processes (from yeast to mammals), cellular senescence, age-related diseases (such as cancer and Alzheimer's disease) and their prevention and treatment, anti-aging strategies and drug development, and, importantly, the role of signal transduction pathways in aging (such as mTOR) and potential approaches to modulate these signaling pathways to extend lifespan. Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

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With an ever-increasing global population grappling with age-related ocular ailments like cataracts, dry eyes, glaucoma, and macular degeneration, the need for new research in this domain is more pressing than ever. In a new study, researchers Kohsaku Numa, Sandip Kumar Patel, Zhixin A. Zhang, Jordan B. Burton, Akifumi Matsumoto, Jun-Wei B. Hughes, Chie Sotozono, Birgit Schilling, Pierre-Yves Desprez, Judith Campisi (1948-2024), and Koji Kitazawa from the Buck Institute for Research on Aging, Kyoto Prefectural University of Medicine, University of Cambridge, and California Pacific Medical Center shed light on a pivotal aspect of corneal health – the impact of ultraviolet-A (UV-A) radiation on corneal endothelial cells. Their research paper was published on the cover of Aging's Volume 16, Issue 8, entitled, “Senescent characteristics of human corneal endothelial cells upon ultraviolet-A exposure.” “The objective of this study was to investigate the senescent phenotypes of human corneal endothelial cells (hCEnCs) upon treatment with ultraviolet (UV)-A.” Full blog - https://aging-us.org/2024/05/uv-a-exposure-cellular-senescence-and-vision-impairment/ Paper DOI - https://doi.org/10.18632/aging.205761 Corresponding author - Koji Kitazawa - kkitazaw@koto.kpu-m.ac.jp Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.205761 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, cellular senescence, senescence-associated secretory phenotype, RNA-Seq, proteomics, gene ontology analysis About Aging-US Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer's diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases. Aging is indexed by PubMed/Medline (abbreviated as “Aging (Albany NY)”), PubMed Central, Web of Science: Science Citation Index Expanded (abbreviated as “Aging‐US” and listed in the Cell Biology and Geriatrics & Gerontology categories), Scopus (abbreviated as “Aging” and listed in the Cell Biology and Aging categories), Biological Abstracts, BIOSIS Previews, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

Do you know what senescent (zombie) cells are and how cellular senescence and senolytics impact health? In this episode of Longevity by Design, hosts Ashley Reaver and Dr. Gil Blander are joined by Dr. James Kirkland from the Mayo Clinic, one of the world's leading figures in aging research. This episode is a deep dive into aging research, cellular senescence, and senolytics. Dr. Kirkland discusses the impact of cellular aging (senescence) on healthspan and his discovery of the first senolytic agents that remove senescent cells and extend healthspan, illuminating his pioneering work in aging research.Dr. Kirkland shares insights into the science of cellular senescence and how selectively eliminating these cells could revolutionize the treatment of age-related chronic diseases. He sheds light on the mechanisms behind senolytics and their promise for extending healthspan. The discussion also touches on the importance of lifestyle factors like diet and exercise in managing senescent cells. Dr. Kirkland also discusses geroscience, a research paradigm that seeks to understand the mechanisms of aging and how this knowledge can be used to slow the rate of aging, reverse its effects, delay or even cure age-related diseases, and extend healthspan. T Dr. Kirkland also covers the challenges and opportunities in translating these scientific discoveries into clinical applications, emphasizing the critical role of interdisciplinary efforts in advancing our understanding and management of aging.This is an enlightening episode with Dr. Kirkland on aging research and the opportunities to revolutionize healthcare by combating aging-related diseases and extending people's health span and lifespan.Timestamps:Introduction: 00:00-03:49What led Dr. James Kirkland to become a physician-scientist and become interested in aging research?: 03:50-05:24What is geroscience, and what are fundamental aging processes?: 05:25-09:17What are the differences between targeting aging vs. the traditional medical system of waiting to treat illnesses or diseases after they occur?: 09:18-12:39What are gerotherapeutics, and what is their relevance for healthspan and lifespan?: 12:40-16:10What are senescent cells? What is the impact of senescent cells on the body and aging: 16:11-26:39What are senolytics? How do senolytics work to target senescent cells to remove them?: 26:40-35:05How Dr. James Krikland discovered senolytics such as fisetin, quercetin, and dasatinib? What clinical trials on the effects of senolytics in humans have been done? 36:06-40:47Discovering biomarkers for senescent cells: 40:48-42:37What are some important factors to consider on the effects of gerotherapeutics and senolytics on lifespan and healthspan in model organisms compared to humans?: 40:38-47:39The potential for geroscience and gerotherapeutics, such as senolytics, to transform healthcare. What is the importance and what are some challenges of conducting clinical trials on gerotherapeutics, such as senolytics, to improve healthspan in humans?: 47:40-56:15What is the Translational Geroscience Network, and what are its goals?: 56:16-01:02:01How might senolytics be used clinically in the future if proven safe and effective? What conditions might they benefit?: 01:02:02–01:05:57What are the effects of lifestyle, such as diet and exercise, on senescent cells?: 01:05:58-01:06:52What excites Dr. James Kirkland the most about the potential for extending people's healthspan and lifespan with therapies, drugs, or interventions in the coming years?: 01:06:53-01:07:41Dr. Kirkland's top tip for health? 01:07:42-01:12:14

@michaelsalzle. In this episode, we discussed pathways of aging. We discuss the importance of genes, AMPK, autophagy, metformin, foods that boost AMPK, autophagy, foods that boost autophagy, spermidine,epigenetics, and cellular senescence

Chicago-based artists Ellen Holtzblatt and Mary Porterfield join Debra Fitzgerald for a conversation about their two-person show at the Miller Art Museum: Vestiges of the Tide. Both artists contemplate a topic in their work that brings awareness to what many of us prefer not to face: senescence, or the process of deterioration as we age, and who we'll be in our final years. The public can meet the artists and view the show March 1. See the Peninsula Pulse for more.

Today, I am blessed to have here with me Dr Nick Bitz. He is a Doctor of Naturopathic Medicine specialising in Ayurvedic medicine. He is presently the Senior Vice President of Product Development at Neurohacker Collective, a company that uses complex systems research to create revolutionary solutions for health and well-being. Dr Nick is interested in Ayurvedic medicine because of his health crisis. When he was a kid, he fell out of a tree, causing a chronic back issue. Not letting his health crisis pull him down, Dr Nick began his journey of self-care and healing. He dives into Buddhist meditation, yoga, and Ayurveda. Eventually, he landed on acupuncture, where he saw the light that he would live a life free of chronic pain. He uses all the tools he can to heal himself. Ultimately, Dr Nick moved to India and focused on Ayurvedic medicine. In this episode, Dr Nick Bitz talks about what cellular senescence is and why it is related to the reason why humans age. He also discusses keeping healthy cells and developing resilience. Aside from that, Dr Nick dives into why fasting is critical to reset our bodies. Tune in as we chat about cellular senescence, fasting, developing resilience,  Qualia Resilience Supplement, and building immune health. Get Qualia products here: neurohacker.com/ketokamp Coupon Code: KETOKAMP (good for 15% off order) Download your FREE Vegetable Oil Allergy Card here: https://onlineoffer.lpages.co/vegetable-oil-allergy-card-download/

The connection between alcohol and gut health is established in scientific literature: alcohol is an inflammatory agent. But as researchers like Vincent Maffei work to improve the quality of life for HIV patients, every bit of information of how that inflammation develops makes a difference, especially in how alcohol and bowel problems connect. Listeners will learn The difference between chronological and biological health and how HIV patients experience increased biological aging, The connection between alcohol and G.I. issues, particularly less diverse microbiota, and The significance of their findings, specifically the abundance of Prevotella spp., a bacteria that may be a mediator between alcohol and cell senescence. Vincent J. Maffei is with the Department of Microbiology, Immunology, and Parasitology at LSU. As a graduate student, he became involved in LSU's Comprehensive Alcohol Research Center (CARC) and studied how dysbiosis accompanies biological aging. He combined this with studying how alcohol affects the intestines, and now studies this specifically with HIV patients. More specifically, he works to find associations between alcohol use and advancing aging in HIV patients and their guts. He explains to listeners about several players in this complex mix of cause and effect: alcohol and gut health as well as alcohol and HIV patients. He establishes that any amount of alcohol can be harmful to someone suffering from HIV. Combine that with an already-established connection with alcohol and dysbiosis in the gut, and researchers are faced with a very real problem to solve for these patients. He does a careful job explaining the background to listeners, bringing in other studies more general to alcohol use and explaining its effect on T-cell senescence, which basically means they lack the ability to copy themselves—limiting their ability to fight infection. Senescence is also a characteristic of biological aging. He explains that the administration of alcohol breaks down the gut barrier, allowing microbes to migrate from the lumen of gut into tissue, which causes inflammation. He also explains their worthy end goal: to identify some sort of microbiota intervention to relieve this component of inflammation in HIV patients, improving their life span and quality of life. Hopefully their findings will lead to more precise mechanisms that can be leveraged in therapeutic modality. For more, see the CARC website: medschool.lsuhsc.edu/alcoholresearch. Take advantage of a 5% discount on Ekster accessories by using the code FINDINGGENIUS. Enhance your style and functionality with premium accessories. Visit bit.ly/3uiVX9R to explore latest collection. Episode also available on Apple Podcasts: apple.co/30PvU9C

Today I am speaking with Dr. Greg Kelly about cellular senescence or zombie cells. Cellular senescence is a hallmark of aging. Today we discuss ways we may be able to combat cellular senescence. Dr. Gregory Kelly is a naturopathic physician (N.D.). He is the lead product formulator at Neurohacker Collective and the author of the book Shape Shift. He was the editor of the journal Alternative Medicine Review and has been an instructor at the University of Bridgeport in the College of Naturopathic Medicine, where he taught classes in Advanced Clinical Nutrition, Counseling Skills, and Doctor-Patient Relationships. Dr. Kelly has published numerous articles on various aspects of natural medicine and nutrition, contributed three chapters to the Textbook of Natural Medicine, and has more than 30 journal articles indexed on Pubmed. His areas of special interest and expertise include nootropics, anti-aging and regenerative medicine, weight management, and the chronobiology of performance and health.

In this episode, Dr. Will Cole is joined by Naturopathic Physician and Senior VP of Product Development at Neurohacker Collective, Dr. Nick Bitz. With expertise in nootropics, anti-aging medicine, biohacking, herbology, nutrition, and dietary supplements, Dr. Bitz shares his fascinating perspective on why longevity all boils down to cellular health. From the top supplements, foods, exercises, biohacking tools, and mind-body practices to support the elimination of inflammatory cells, to exactly how these impact longevity and why you should care in the first place, this episode will give you the exact roadmap for youthful skin, vibrant health, and a longer life. Plus, he shares the incredible science behind Neurohacker's anti-aging, cell-repairing products and why you should consider adding them into your supplement regimen. For all links mentioned in this episode: www.drwillcole.com/podcastPlease note that this episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct or indirect financial interest in products or services referred to in this episode.Sponsors:Go to boncharge.com/WILLCOLE and use coupon code WILLCOLE to save 15%.Go to Puori.com/WILLCOLE and use promo code WILLCOLE for 20% off site wideTo get your twenty percent off, just text ABW to 64000. Message and data rates may apply. See terms for details.Visit www.hummkombucha.com and use code drwillcole for 15% off your total order. Find Humm on Amazon for free shipping with Amazon Prime and delivery to anywhere in the US!Go to neurohacker.com/willcole for up to $100 off and use code WILLCOLE at checkout for an additional 15% off.Produced by Dear Media.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This episode of Longevity by Design features an interview with Dr. Eric Verdin—the CEO of The Buck Institute. The Buck Institute was the first center dedicated to aging research, and many discoveries within the aging field have come out of this research center. For this episode, Dr. Verdin, Dr. Blander, and Ashely Reaver sat down in person to discuss the latest updates in longevity research. Dr. Verdin shares his opinion on questions like “is aging a disease?” and “is there a maximum lifespan that humans will never surpass?” Dr. Verdin also discusses updates on the future of anti-aging drugs, including senolytics and metformin. To close the episode, Dr. Verdin gives life advice for what 5 things we can do on a regular basis to improve our health span.Listen to all episodes of Longevity by Design at https://info.insidetracker.com/longevitybydesign Episode timestamps: Introduction: (0:00–2:40) About the Buck Institute (2:40–8:00)Biological aging clocks (8:00–14:31)Public opinion and funding aging research (14:31–16:38) Is aging a disease? (16:38–19:35) Future of anti-aging drugs (19:35–25:25) Senescence and senolytics (25:25–29:42) The hallmarks of aging are interconnected (29:42–36:48) How medicine and public policy has improved life expectancy (36:48–40:50) How much of longevity is due to genetics? (40:50–44:52) Geographic location impacts life expectancy (44:52–51:08) Is there a maximum lifespan for humans? (51:08–56:40) Healthspan vs lifespan (56:40–60:04) The most important interventions to improve healthspan (60:04–1:06:04)  

Grandpa Bill talks Senosense and Senolytic Drugs for Aging:What are senescent cells? How do senescent cells form? DNA damage:  Telomere shortening:  Oxidative stress:  What are the effects of senescent cells? Secrete a variety of inflammatory molecules:  Interfere with tissue repair: Contribute to cancer:. How can we target senescent cells? Senolytic drugs:  Senescence-modifying drugs:  What are the potential benefits of targeting senescent cells? Slowing down aging: ng or delaying age-related diseases: What is the future of senescent cell research? Senescent Cells and Their Impact on Cognitive Function Mechanisms Underlying Senescent Cell-Induced Cognitive Decline Neuroinflammation: Impaired Neurogenesis: Disruption of Synaptic Function: Evidence Supporting the Role of Senescent Cells in Cognitive Decline Animal Studies: Human Studies: Potential Therapies Targeting Senescent Cells for Cognitive Enhancement Senolytic Drugs: Senescence-Modifying Drugs: #SenescentCells, #Aging, #Cognition, #CognitiveDecline, #Alzheimer's, #Dementia, #Neurodegeneration, #SenolyticDrugs, #SenescenceModifyingDrugs, Relevant Citations and Websites Episode 1: Unraveling the Mystery of Senescent Cells: Unveiling the Aging Symptoms What are Senescent Cells? Aging Symptoms Linked to Senescent Cell Accumulation Skin Aging: Tissue Repair Impairment: . Immune System Decline: Cancer Risk: Episode 2: Combating Aging with Senescent Cell Therapies Introduction Senolytic Drugs: A Promising Approach Senescence-Modifying Drugs: An Alternative Approach Promising Research Regarding Senolytic Drugs Preclinical Evidence Clinical Trials Future Directions  See the latest updates to my granddaughter- Adah's Academic Excellence Mandarin to english the following Words " Adah,I love you so much, and I am so very proud of your latest first half year of your Junior Year In High School. What a amazing accomplishment. Four A+ and 2 A's, 9th in your class. Great Job sweetie your on your way to continuing your aspirations" Please show the actual words, so I can practice my tonal inflections best hashtags and suggested titlesvolume_up Here is the translation from Mandarin to English of the following words: 阿達，我非常愛你，並且我非常為你高中三年級上半學期取得的最新成績感到驕傲。真是太棒了。四個A+和四個A，全班第九名。好工作，甜心，你正在努力實現自己的抱負。 Here is the breakdown of the translation: 阿達 (Adah) - This is the name of the person being addressed. 我非常愛你 (I love you very much) - This is a way of expressing love for someone. 並且我非常為你高中三年級上半學期取得的最新成績感到驕傲 (and I am very proud of your latest grades in the first half of your junior year of high school) - This is a way of expressing pride in someone's accomplishments. 真是太棒了 (What a great accomplishment) - This is an exclamation of praise or admiration. 四個A+和四個A，全班第九名 (Four A+s and four As, ninth in the class) - This is a statement of academic achievement. 好工作，甜心 (Good job, sweetie) - This is a way of expressing congratulations or encouragement. 你正在努力實現自己的抱負 (You are on your way to achieving your aspirations) - This is a statement of support and encouragement. #ProudParent #AcademicAchievement #JuniorYearSuccess #AdahsJourney Title: Adah's Academic Excellence: A Journey of Dedication and Success 阿达，我非常爱你，并且我非常为你高中三年级上半学期取得的最新成绩感到骄傲。真是太棒了。四个A+和四个A，全班第九名。好工作，甜心，你正在努力实现自己的抱负。 阿达 /ā dá/，我非常爱你 /wǒ fēicháng ài nǐ/，并且我非常为你高中三年级上半学期取得的最新成绩感到骄傲 /bǐngqiě wǒ fēicháng wéi nǐ gāozhōng sānniánjí shàngbànxuéqí qǔdé de zuìxīn chéngjī gǎodào jiāo'ào/。真是太棒了 /zhēn shì tài bàng le/。四个A+和四个A，全班第九名 /sì ge A+ hé sì ge A, quánbān dìjiǔ míng/。好工作，甜心 /hǎo gōngzuò, tiánxīn/，你正在努力实现自己的抱负 /nǐ zhèngzài nǔlì shíxiàn zìjǐ de bàofù/。 --- Send in a voice message: https://podcasters.spotify.com/pod/show/bhsales/message

Show Notes for Episode Twenty-Six of seX & whY: Sex and Gender Differences in Aging Host: Jeannette Wolfe Guest: Sara Haag Dr Haag is a researcher in molecular epidemiology who studies human biological aging at the Karolinska Institute in Stockholm. Background - Dr Haag has a PhD in functional genomics and Post Doc in genetic and molecular epidemiology. She studies telomeres and molecular association with telomere length, she also has experience in molecular biology and computer science. Definitions and discussion points from podcast Geroscience - a new field of biomedical science that looks at how the molecular, genetic, and cellular mechanisms associated with the aging process itself may interact and even trigger many diseases associated with aging. This research provides a different angle for potential intervention to enhance health and longevity.  Life Span - time between birth and death. Heath Span - time within life span of good health. Frailty Index and Clinical Frailty Scale are tools that evaluate a patient's overall physical conditioning and their vulnerability to certain adverse outcomes including falls, increased care requirements, hospital admission,  and mortality.  Epigenetics - the study of how DNA expression can be modified by behavior or environmental factors (versus alteration in the actual DNA itself). One way I think of this is to imagine a huge library full of books, and that each book represents a gene coded from our DNA- epigenetics help determine which books get pulled off the shelfs and get read or pushed back deeper into the shelfs.  This process is different than buying new books for the library (which would be equivalent to changing the DNA itself.)  Aging Scales - as different elements of the body age differently, there is not a gold standard to measure aging. Dr Haag recently published a study that evaluated a bunch of these different scales and determined that the “ideal” scale will vary dependent upon what you are studying- such as overall function or the biological aging of a specific organ (i.e. heart or liver).   Two major theories of aging: Senescence theory of aging - the belief that with age, cellular systems due to repeat exposure to intracellular and extracellular stressors, eventually start to malfunction and breakdown.  Things start slowly falling apart due to wear and tear.  Programmed theory of aging - Aging is an innate active process which is highly regulated by an internal time clock.  As the field of Geroscience and epigenetics evolves, the “truth” around aging is likely to be a combo of both theories.  Sex Differences Hormones Estrogen Dr Haag talked about research involving telomere length (telomeres are the cap of the chromosome and they help protect the chromosomes from damage.) Typically, telomeres shorten with repeated division in somatic cells and when they shrink to a certain length the cell is more vulnerable to error and damage. Females have longer telomere length at birth compared to males and there is evidence that women with longer exposure to estrogen have longer telomeres.                    Testosterone Here is the Korean Eunuch study mentioned in the podcast.  The researchers examined a genealogical record of 385 eunuchs and compared their life span to several other groups of men who lived during the same time periods including a bunch of kings. They found that the average life span of a eunuch was 70 which was 15-19 years longer than the comparison groups. One theory behind this difference in longevity is “the disposable soma theory”. This postulates that in males there is competition between two different intrinsic systems - somatic aging and reproduction- and that as both systems require significant energy to maintain,  when energy is diverted to one system the other suffers.   Sex Chromosomes In females each cell has two X chromosomes. In female cells, one of the X chromosomes is typically inactivated so that some cells have genes expressed that are inherited by their father, while others express genes inherited from their mother. Complicating this further is that several genes do not fully inactivate that second X chromosomes so that females may have an “extra” expression of some genes. A concrete example of this is the gene Toll like receptor 7 which codes for proteins that helps the immune system recognize the early invasion of certain types of viruses. As this gene doesn't undergo X inactivation, it may give females an extra boost in warding off certain types of viral infections.  With aging there can be “skewing” of the X chromosome in that females may have a disproportionate percentage of cells that express the X chromosomes of a single parent.   As male cells age, some may actually lose their Y chromosome. This news release suggests that his may happen relatively frequently as their work implied that 40% of all 70-year-olds had cellular evidence of it.  The loss of Y chromosome can be associated with Alzheimer's and heart disease in males.    Take home points: 1)    The field of aging is absolutely exploding. Someday it may be possible to actively manipulate epigenetic signaling to slow or even reverse aging processes.   2)    Different biological processes in our bodies age at different rates. Plus, if you follow a group of people over time, as they get older there will be greater and greater differences within that group in their markers of aging. 3)    In aging research, there has historically been two different camps- the senescence camp, and the programmed theory one. In the senescence camp is the belief that as we age, things just start breaking down due to natural wear and tear. This contrasts with the programmed theory camp which believes that aging is a pre-designed active process that is triggered with age. The “truth” likely is a combination of both theories with epigenetics being the bridge.  4)    Sex differences in aging include the mortality-morbidity paradox in that although females tend to have poorer health and greater fragility risk, males still tend to die sooner.  5)    Sex differences with aging may include changes in the X chromosome with increased skewing and even the loss of the expression of the Y chromosome, both of which can be associated with an increase of health-related issues.  Thanks for listening. May you be well (and curious).  Jeannette.

Dr. Amit Sharma was awarded a Master's degree in Biomedical Sciences from Delhi University, India. He received his PhD in 2009 in Biotechnology from University of Pune for his work demonstrating microRNA regulation of cytokines invovled in allergic inflammation in mice models. Dr. Sharma's postdoctoral research at the Buck Institute, Novato, California involved investigating novel molecular regulatory pathways in regards to genotoxic stress and cellular senescence in invertebrate and mammalian models. Dr. Sharma has recently joined SENS Research Foundation as Group Lead in the Senescence Immunology Research Group. His research focus involves studying how aging and senescence affects the immune system and his research group will also investigate strategies to harness the immune system in mitigating deleterious effects of senescent cells with translational focus. Newsletter sign up (new and exciting developments)https://learningwithlowell.us12.list-manage.com/subscribe?u=08ed8a56013d8b3a3c01e27fc&id=6ecaa9189b Join this channel to get access to perks: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-Q/join https://youtu.be/8QwvcRvsT_0 Over 321 books from 170 plus interviews over 5 yearshttps://www.learningwithlowell.com/over-321-books-from-170-interviews-over-5-years-for-autodidacts/ PODCAST INFO:The Learning With Lowell show is a series for the everyday mammal. In this show we'll learn about leadership, science, and people building their change into the world. The goal is to dig deeply into people who most of us wouldn't normally ever get to hear. The Host of the show – Lowell Thompson- is a lifelong autodidact, serial problem solver, and founder of startups. LINKSSpotify: https://open.spotify.com/show/66eFLHQclKe5p3bMXsCTRHRSS: https://www.learningwithlowell.com/feed/podcast/Youtube: https://www.youtube.com/channel/UCzri06unR-lMXbl6sqWP_-QYoutube clips: https://www.youtube.com/channel/UC-B5x371AzTGgK-_q3U_KfAWebsite: https://www.learningwithlowell.com/ Amit Sharma Linkshttps://www.sens.org/about-us/team/https://youtu.be/AoRb1Z0XanMhttps://www.sens.org/our-research/https://www.linkedin.com/in/amit-sharma-1613b189/ Timestamps00:00 Dr. Amit Sharma00:45 Which path to achieve longevity/ healthspan02:40 integrated approach03:50 Typical week working on longevity07:20 Black swan events / SENS foundation08:30 Too high risk ideas09:09 Innovation brain / Elon Musk10:50 Dyslexia thinking in 3d and how Amit thinks12:40 Seeing opportunities14:20 Amit Sharma Leadership style16:00 Spinning off companies vs staying in pure research18:30 Mentorship, life events, inspiration and seeing longevity as the path for her21:00 Skills to be successful in longevity24:55 Project / moments at SENS that is awesome27:15 Longevity and Iron30:17 Visualizing senescence apoptosis32:30 Other uses / Cancer applications / USF34:40 Immune system not aware of eyes35:52 Blood brain barrier degradation with ate, NK cells, t cells36:47 T -cells, inflammation, and alzheimer's38:44 Crazy ideas for treating alzheimer's disease40:40 Cost to build an Amit Sharma center of research within SENS / Idea for Lisa43:00 Donating money to SENS / mito mouse45:00 Ancient infections hiding in genome47:35 Gut microbiome longevity Drosophila52:25 Mice / research / history of work56:30 Cell culture, senescence, mouse models creating new perspectives57:40 FanQ How do you know that the allogeneic CAR-NK cells won't cause Graft vs Host disease?1:00:01 FANQ How many possible senescent cell markers do you think there may be in senescent cells? Do you see being able to target say 70% of Senescent cells with just say 10 markers?1:03:50 FANQ How far do you think you are from an IND application?1:05:55 FANQ Do you have an orphan indication you might want to target first?1:06:50 Book recommendations1:10:00 Amit on never retiring1:10:30 What he needs help with

In this episode Sal, Adam & Justin speak with hormone and peptide expert, Dr. William Seeds about the amazing healing properties of BPC 157. What's the connection between BPC 157 and GHRP (Growth Hormone Release peptides)? (2:29) Bodybuilders and IGF-1 (Insulin-like Growth Factor 1). (9:08) Don't get caught up in measuring IGF-1. (13:08) Any worries with Growth Hormone-Releasing Hormone (GHRH) regarding insulin sensitivity? (16:51) If you don't have muscle mass everything is going to go wrong. (21:09) MK-0667 (Ibutamoren mesylate) benefits. (25:03) The difference between oral vs injection as the delivery method for BP 157. (30:25) How BPC 157 improves your body cells to do what they normally do. (36:08) Does BPC 157 help modulate cancer? (38:37) How collagen can enhance healing. (47:17) The areas of the body that BPC 157 is most beneficial. (50:00) Keeping up with his kids through fitness. (53:15) Related Links/Products Mentioned TRANSCEND your goals! Telehealth Provider • Physician Directed GET YOUR PERSONALIZED TREATMENT PLAN!  Hormone Replacement Therapy, Cognitive Function, Sleep & Fatigue, Athletic Performance and MORE. Their online process and medical experts make it simple to find out what's right for you. Visit PRx Performance for an exclusive offer for Mind Pump listeners! July Promotion: MAPS Starter | MAPS Starter Bundle 50% off! **Code JULY50 at checkout** Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts Effects of tesamorelin on non-alcoholic fatty liver disease in HIV: a randomised, double-blind, multicentre trial The Resistance Training Revolution – Book by Sal Di Stefano Boosting brain's waste removal system could improve Alzheimer's outcomes Senescence and cancer — role and therapeutic opportunities Mind Pump #2122: Deadlift Masterclass Mind Pump Podcast – YouTube Mind Pump Free Resources Featured Guest Dr. William Seeds (@williamseedsmd) Instagram Dr. William Seeds | Seeds.md  

Our skin was designed to function as a barrier to protect our bodies from environmental stressors and pathogens, but unfortunately, our skin barrier is one of the main factors that is compromised as we age. Many of us are constantly looking for the next best thing to slow down and possibly even reverse these signs of skin aging, and my guest today is here to explain why focusing on products that work on the molecular level is the key to healthy aging.   I'm joined by Carolina Oliveira, the CEO and co-founder of OneSkin, to discuss everything you need to know about healthy aging in the skin. We cover cellular senescence, biological age, systemic inflammation, and the research being done at OneSkin to quantify these things. We also talk about some of the other factors that have an impact on skin health, and of course dive into the first peptide developed to reverse skin aging at the molecular level: OS-O1.   Carolina Oliveira is the CEO and co-founder of OneSkin. She holds a Ph.D. in stem cell biology and tissue engineering, is a co-inventor of 5 patents and co-author of numerous scientific publications. She relocated from Brazil to Silicon Valley in 2016 to found OneSkin, a fast-growing longevity company developing products to promote skin health by targeting aging at the molecular level. Carolina is an alumnus of IndieBio, the world's largest biotech accelerator and has been an active voice in the longevity field, pioneering age reversal skin research with OneSkin.  Thank you to our sponsors for making this episode possible: OneSkin: Use code SUPERHUMAN15 at https://www.oneskin.co/ BiOptimizers: For Sleep Breakthrough use code BIONAT10 at checkout to save 10% at sleepbreakthrough.com/bionat Berkeley Life: Consumers may register and place an order using my code NIDDBL for 10% off at berkeleylife.com Neurohacker Collective: https://bit.ly/QNHNat and use code NN15 Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat's Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08   Find more from Carolina Oliveira: Website: oneskin.co   What we discuss: [00:03:24] The skin barrier and why our skin becomes more fragile as we age [00:08:30] Does nutrition have a big impact on skin health? [00:16:05] The skin's biological age clock [00:22:48] Does cellular senescence affect skin elasticity? [00:28:07] Ingredients to avoid when looking for skincare  [00:35:37] How long does it take to see results from OneSkin products?  [00:43:22] How OneSkin products can potentially lower systemic inflammation [00:50:09] The different concentration of OS-O1 in each product Key Takeaways: Cellular senescence is a process in which cells stop dividing after reaching their replication limit of around 50 times. These cells have accumulated various mutations that can lead to cancer if they continue to divide. Therefore, cellular senescence functions as a protective mechanism for the body. However, these senescent cells also secrete inflammatory signals that can cause neighboring cells to age faster. When it comes to choosing skincare products, it is important to pay attention to the ingredients list. Some ingredients, like parabens and fragrance, can cause irritation or harm to the skin. Parabens are preservatives that have been linked to endocrine disruption, while fragrance can cause allergic reactions or sensitivity.  Websites like EWG can be a helpful resource for checking the safety of skincare products and their ingredients.  Advanced Glycation End-products (AGEs) are naturally occurring compounds that are formed when glucose reacts with proteins in the body. The accumulation of AGEs in the skin leads to the degradation of collagen and elastin fibers, which are responsible for keeping the skin firm and elastic.  

Did you know that by the age of 40-50, people have anywhere between 10 to 30% senescent cells in their tissues? Senescent cells are one of the hallmarks of aging, and can disrupt physiology throughout the body. Cellular senescence is the process by which cells permanently stop dividing but do not die off. These senescent cells linger inside the body and accumulate over time, affecting the healthy function of tissues and organs as we age.   I'm joined by Dr. Nick Bitz, and we're diving into everything you need to know about senescent cells and cellular senescence. We discuss why our bodies need some senescent cells, and some of the lifestyle changes we can make to support the body's ability to clear senescent cells. Plus, we answer the question: How young is too young to be worried about your senescent cells?    Dr. Nick Bitz is a Naturopathic Physician that specializes in Ayurvedic medicine. He is a leading voice in the natural products industry and currently serves as Senior VP of Product Development at Neurohacker Collective. His areas of expertise include nootropics, anti-aging medicine, biohacking, herbology, nutrition and dietary supplements. Thank you to our sponsors for making this episode possible: Add Neurohacker's Senolytic to your longevity routine by using code NATHALIE at neurohacker.com/nathalie  LMNT: Use Drinklmnt.com/NAT to get 8 free single serves with any order to try different flavors. Profound Health: Use code longevity15 to save 15% off your first order at https://profound-health.com/ Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat's Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08   Find more from Dr. Nick Bitz: Website: https://neurohacker.com/ Instagram: https://www.instagram.com/neurohacker/ Facebook: https://www.facebook.com/neurohackercollective LinkedIn: https://www.linkedin.com/in/nick-bitz-283a03b/   What we discuss: [00:04:18] Why our bodies need some senescent cells  [00:11:34] How young is too young to be worried about your senescent cells?  [00:19:18] Lifestyle changes to support the body's ability to clear senescent cells  [00:30:43] Optimizing health throughout the entire body [00:40:53] Targeting different communities of senescent cells  [00:47:21] The importance of intermittent fasting Key Takeaways: 40 years old is the age where it is especially important to start taking steps to prevent senescent cells from accumulating in the body and causing age-related diseases, inflammation, weakened immune system, and cell damage.  Autophagy is the process by which cells break down and recycle their own components. Promoting autophagy can help reduce the formation of senescent cells, as it can help the body remove damaged cells and other debris that can accumulate and lead to cell senescence.  Senescent cells can accumulate in different tissues and organs, such as the skin, heart, and lungs, and can disrupt normal function. Therefore, it is important to address senescent cells in all tissues and organs to ensure optimal health.  

Let's discuss how how different macronutrients and blood sugar issues can regulate aging and the induction of cellular senescence. We also discuss how various dietary interventions can achieve prevention of disease and extension of lifespan by modulating senescence. Sponsored Message: Support your Intermittent Fasting lifestyle with the updated Berberine HCl Fasting Accelerator by MYOXCIENCE: Use code podcast to save 12% Link to Articles & Images: https://bit.ly/42kjEen Show Notes: 00:25 Cellular senescence accelerates biologic ageing. 02:00 Senescent cells are enlarged, have dysfunctional mitochondria, and release pro-inflammatory signaling molecules. 02:30 Senescence manifests as wrinkles, memory loss, muscle loss, gray hair, fatty liver, excessive visceral adipose tissue. 03:45 Senescence occurs in response to stressors or developmental signals and behave similar to cancer cells. 05:45 Dysfunctional mitochondria influences glycolysis in cells. 06:15 Give your cells less fuel, glucose, for the proliferation of inflammation. 07:45 Hyperglycemia decreases nitric oxide, which helps prevent cellular senescence. 08:00 Sirtuins can inhibit the formation of senescent cells. 08:55  Berberine, Metformin, and low dose rapamycin, have been used to mitigate hyperglycemia. 10:30 Hyperglycemia also impacts your cardiovascular system and endothelial cells. 12:00 Fat cells can become senescent. 13:00 Ketones (BHB) can help inhibit cellular senescence. 13:25 Optimized omega 3 to omega 6 ratio can help. 14:00 Exercise counters age-related accumulation of senescent cells. 14:40 Senescence within your immune cells is linked with cancer and poor response to infection.

Today, I am blessed to have here with me Dr Nick Bitz. He is a Doctor of Naturopathic Medicine specialising in Ayurvedic medicine. He is presently the Senior Vice President of Product Development at Neurohacker Collective, a company that uses complex systems research to create revolutionary solutions for health and well-being.