Podcasts about mice

Erik Marino details his brutal vertigo battle (inner ear crystals spinning him out, Epley maneuver gone wrong, and possible mouse-related Hanta fears), while Ron the Waiter gets grilled for his suddenly darker “beach hair” that definitely isn't dye. The guys spiral into Blue Steel impressions, movie quote wars, Monica turning 53, and a fortune cookie that swears December will be chill. Pure unfiltered chaos.Thanks for dontaing to the show https://www.paypal.com/ncp/payment/JANCGHFW7GJHA helps me to keep this going.  Peace!

Hello everyone!Robin was in Joseph and his Amazing Technicolour Dream Coat and Juno went to watch it with Mummy and Daddy, and we have an interview with Mrs Mice-alot.Plus Ask the 8 Ball, Farty Facts, Juno's Book Review, True Story, Mice News and Joke of the Week.We love you all!Email: robinandjuno@gmail.com

On today's pages, ⁠Chullin 78 and 79, the Talmud invites us to think more deeply about the animals with whom we share the world. Recorded around a barbecue table in upstate New York, this special summer episode with Rabbi Dovid Bashevkin and producer Josh Kross explores why Judaism teaches both profound compassion for animals and a profound appreciation for what makes human beings different. How do we honor both without diminishing either? Listen and find out.

What started as a simple garage cleanup turned into one of the most unexpected wildlife rescues we’ve ever experienced! While getting organized for an upcoming yard sale, Leah discovered a mother mouse and five tiny babies hiding in a box. We share the surprisingly heartwarming story of how Mom made her escape, how we safely […] The post We Rescued Baby Mice… Then Everything Went Wrong appeared first on The ESO Network.

Group Leader in the Cancer Immunology Program at the Peter MacCallum Cancer Professor Paul Beavis joined Ross Stevenson and Russel Howcroft to discuss how this testing could impact cancer in humans.See omnystudio.com/listener for privacy information.

Broadcast from KSQD, Santa Cruz on 7-09-2026: Researchers refined a technique to reverse skin cell aging by about 30 years while preserving cellular identity. Exposing adult fibroblasts to Yamanaka factors—stopping before full reversion to pluripotent stem cells,reset the epigenetic clock and gene expression patterns to resemble much younger cells. The rejuvenated fibroblasts produced significantly more collagen, migrated faster to close artificial wounds, and showed reversal of gene expression patterns associated with Alzheimer's and cataracts. Since long-term epidemiologic data doesn't yet exist, Dr. Dawn follows up on last week's vaping question by exploring cancer mechanisms. Vaping aerosols impair DNA repair fidelity while triggering IL-6, IL-8, and TNF-alpha secretion. Nicotine-derived nitrosamines, reactive carbonyls (formaldehyde, acetaldehyde, acrolein) are generated when propylene glycol and vegetable glycerin are heated. Upregulated cytochrome P450 enzymes convert precarcinogens like benzopyrene into carcinogens. Mice exposed for 54 weeks developed lung adenocarcinomas in 22% and precancerous bladder hyperplasia in 57%, with markers matching those show predict lung cancer years before diagnosis. The Mexican Biobank—which includes over 40,000 samples from all 31 Mexican states revealed dramatic regional variation in drug-metabolism genes driven by Indigenous ancestry. In Chiapas, nearly 40% of the population carries two copies of a CYP2D6 variant reducing fentanyl metabolism, versus just 10% in Sinaloa. The SLCO1B1 variant hindering statin metabolism is found in over 15% of Yucatán residents., where 8 million Mexicans take statins. Dr. Dawn discusses both the promise and potential dark side of population genetic testing, including UK plans to genotype all children at birth for inborn errors of metabolism. Dr. Dawn briefly revisits the recent Indian study showing conch-shell blowing reduces sleep apnea by 34%, comparing it to earlier didgeridoo research, both of which strengthen airway muscles through forced-blowing exercises. A caller from Capitola recovering from non-Hodgkin's lymphoma near the L5 nerve asks about Japanese Kampo medicine formulas (Goshajinkigan, Yokukansan) for post-treatment nerve pain. Dr. Dawn suggests the pain likely originates from scar tissue tethering the nerve, and recommends consulting the Oriental Medicine Doctor program at Five Branches in Santa Cruz where faculty can advise on herbal formulas that trace back thousands of years through cultural exchange between China and Japan. Dr. Dawn explains Lp(a):lipoprotein(a), a small protein string attached to LDL particles that promotes clumping and clotting, is a genetically-determined coronary artery disease and stroke risk factor invisible to standard lipid panels. Levels of 250 particles double coronary risk and 350 particles triple it. Less than 75 is normal. Two new pharmaceutical strategies are in development to reduce Lp(a) : antisense oligonucleotides (single-stranded RNA that recruits RNase H to cleave target mRNA) and small interfering RNA (double-stranded RNA that triggers destruction of matching mRNA). Pelacarsen, a monthly injection in Phase 3 trials, reduces Lp(a) by 80%. These gene-silencing platforms open therapeutic possibilities for previously undruggable orphan diseases. Vitamin K2 is produced in the gut microbiome. MK-4 is most common in humans. Dr. Dawn recommends MK7 for stabilizing coronary calcium plaques and directing calcium into bone. A study of hepatitis B and C patients found MK4 to be protective in hepatocellular carcinoma. HCC developed in 2 of 21 MK-4-treated patients versus 9 of 19 controls, with a risk ratio of 0.2. MK-4 activates protein kinase A in vitro, inhibits HCC invasiveness, and restores apoptosis signaling that cancer cells normally block. Dr. Dawn recommends a couple milligrams of MK-4 daily for anyone with cirrhosis or prior hepatitis B or C infection.

The Mothers Of Invention- Paralipomeni Della Batracomiomachia  Paris- 1970The December 1970 Paris gig was a standout date during their European tour. The setlist included iconic Zappa tracks and heavy improvisations like "Dog Breath," "A Pound for a Brown on the Bus," and "Call Any Vegetable". The band featured an incredible lineup that included:Frank Zappa (Guitar/Vocals)Mark Volman & Howard Kaylan (better known as Flo & Eddie)Ian Underwood (Keyboards/Woodwinds)Jeff Simmons (Bass)Aynsley Dunbar (Drums)Frank Zappa and The Mothers of Invention performed this legendary concert at the Gaumont-Palace in Paris, France on December 15, 1970. The show famously featured renowned French jazz violinist Jean-Luc PontyBatracomiomachia: Translates from Ancient Greek as the "Battle of the Frogs and Mice" (a classical comic epic parodying the Iliad).Paralipomeni: An Italian term for an appendix, sequel, or "things left out". The Italian poet Giacomo Leopardi wrote a famous satirical continuation titled Paralipomeni della Batracomiomachia in 1831.1 |  | Penis Dimention | 11:262 |  | The Air | 3:533 |  | The Dog Breath / Mother People | 4:234 |  | You Didn't Try To Call Me | 3:345 |  | King Kong | 32:416 |  | Who Are The Brain Police? | 6:32

Córdoba reúne esta semana a más de 200 profesionales del sector MICE con motivo del III Congreso conjunto de la Asociación de Ferias Españolas (AFE) y la Asociación de Palacios de Congresos de España (APCE). El encuentro abordará los principales retos de la industria ferial y congresual, desde la inteligencia artificial y la digitalización hasta la sostenibilidad y la captación de talento.Extremadura promociona su oferta de turismo ornitológico en la Global Birdfair, la principal feria internacional especializada en observación de aves, que se celebra este fin de semana en el Reino Unido. La región presenta una renovada imagen de su Club Birding Extremadura con el objetivo de reforzar su posicionamiento como destino de naturaleza y atraer a un viajero internacional de alto valor añadido.Cinco Estrellas Club cerró el primer semestre de 2026 con un crecimiento del 10% en sus ventas, pese a la ralentización de las reservas registrada en las últimas semanas. El turoperador atribuye este resultado al buen comportamiento de destinos como Turquía, Egipto y los viajes de larga distancia, así como al respaldo continuado del canal de agencias.HolaCamp prevé alcanzar una ocupación media del 90% durante julio y rozar el lleno en varios de sus campings durante agosto, impulsada por la fuerte demanda de alojamientos en plena naturaleza y el auge del glamping. La compañía estima una estancia media de 4,8 noches y confía en mantener el buen comportamiento del sector durante toda la temporada estival.

Whether you knew her for "Total Eclipse of the Heart" or "I Need a Hero" (which was made famous in the Utah-made movie "Footloose"), Bonnie Tyler was a major part of the 80s music scene. Overnight, she passed away at the age of 75. Greg and Holly reminisce about her before turning to a new discovery from scientists: elephants aren't actually scared of mice. Wait what?

Mallorca afronta la temporada alta con unas reservas de verano un 3% superiores a las del año pasado, impulsadas por la recuperación del mercado alemán y el reposicionamiento de la oferta hotelera. Según un informe elaborado por PwC para la Federación Empresarial Hotelera de Mallorca (FEHM), el destino mantiene su liderazgo en el Mediterráneo gracias al aumento del gasto turístico, la mejora de la conectividad aérea y el crecimiento del canal directo.LePlan y Touring Club, marcas especializadas de Ávoris, han integrado Walt Disney World en su sistema de reservas, permitiendo a las agencias contratar hoteles, entradas y otros servicios del complejo de Orlando desde una única plataforma. Según el anuncio realizado por LePlan y Touring Club, esta integración agiliza la gestión de las reservas y amplía las opciones de venta para las agencias de viajes.La Junta de Castilla y León ha presentado su oferta de turismo de reuniones e incentivos ante más de 170 profesionales durante el III Foro Castilla y León MICE, celebrado en Ávila. Según la información difundida por la Junta de Castilla y León, el encuentro busca reforzar el posicionamiento de la comunidad en el segmento MICE, favorecer las relaciones comerciales entre empresas y mostrar la diversidad de espacios y servicios disponibles para la organización de eventos.Cuatro empresas del Pirineo aragonés se han unido para crear un centro de turismo de montaña pionero que ofrecerá formación, actividades y experiencias vinculadas al medio natural durante todo el año. La iniciativa pretende impulsar un modelo de colaboración empresarial que contribuya a desestacionalizar la actividad turística y reforzar la competitividad del territorio.Ryanair ha reclamado al Gobierno español que actúe con urgencia para resolver los problemas del control aéreo gestionado por ENAIRE, después de que las incidencias registradas durante las últimas semanas provocaran cientos de retrasos y afectaran a miles de pasajeros. En un comunicado de la compañía, la aerolínea insta a reforzar la plantilla de controladores y adoptar medidas que eviten nuevas interrupciones durante la temporada alta.

Send us Fan MailJumping into the time machine today, back to 1968 when a researcher built a paradise for mice. A place with unlimited food, total safety, nothing to fear, and watched the whole thing fall apart anyway.Support the showJoin the Patreon community https://www.patreon.com/richardnichollsSocial Media LinksBluesky https://bsky.app/profile/richardnicholls.netThreads https://www.threads.net/@richardnichollsrealInstagram https://www.instagram.com/richardnichollsrealFacebook https://www.facebook.com/RichardNichollsAuthorYoutube https://www.youtube.com/richardnichollsTikTok https://www.tiktok.com/@richardnichollsauthorX https://x.com/richardnicholls

Full show notes: https://bengreenfieldlife.com/mitrix In this episode with Tom Benson, founder and CEO of Mitrix, you'll hear why mitochondrial decline may be the actual root cause of aging rather than just a downstream symptom of it, and why most of the drugs developed so far to address it don't touch the real problem: damaged mitochondrial DNA. We discuss how Tom's company grows new, healthy mitochondria inside a bioreactor using banked stem cells, what mitochondrial transplantation actually looks like in real human cases already happening today, and the mouse study that gives this episode its name, in which severely aged mice receiving repeated mitochondrial injections were, according to the technicians running the experiment, climbing the walls of their cages by the very next day. Tom also touches on his original theory on the mitochondrial cycle of the body, how mitlets differ from naked mitochondria, and what his own MitoClock test reveals using nothing more than a urine sample. Tom Benson is the CEO and founder of Mitrix. He is a serial entrepreneur and scientist who has founded four successful software, hardware, and science startups. He has published dozens of articles and video lectures on mitochondrial science and cellular energetics, and developed original theories on the systemic transfer and distribution of mitochondria within higher organisms and how that affects health and lifespan. Episode Sponsors: Troov: An all-natural energy powder combining green tea caffeine, L-theanine, beetroot, amino acids, adaptogens, and electrolytes for steady energy and focus without the crash. Visit DrinkTroov.com/BEN and use code BEN for 30% off your first order, plus free shipping and a 30-day money-back guarantee. Our Place: Upgrade to a kitchen free of forever chemicals. Go to fromourplace.com/ben and use code BEN for 10% off sitewide. BON CHARGE: A holistic wellness brand with products that address sleep, performance, recovery, hormone balance, and inflammation. Go to boncharge.com/GREENFIELD and use code GREENFIELD to save 15%. Tecton Ketones: Bioidentical D-beta-hydroxybutyrate (BHB) for clean cognitive support, stable energy, and performance without the conversion step required by many ketone precursors. Visit tectonketones.com/ben and use code BEN for 16% off your first order. LYMA Laser: An advanced at-home skin technology backed by peer-reviewed research showing it influenced 45 genes in human skin compared to just one for an equivalent LED device. Visit lyma.life and use code BEN10 for 10% off for a limited time.See omnystudio.com/listener for privacy information.

Bob Zimmerman reports research showing weightlessness harms reproduction in mice, suggesting humans will need artificial gravity for long-term missions. On Mars, Curiosity discovered unique polygon ridges, possibly indicating ancient water. Additionally, New Horizons confirmed the solar wind slows at the solar system's edge. (8)IDAHO

In this week's episode, Blood editor Dr. James Griffin interviews Drs. Heinz Zoller and Raul Ribeiro on their latest articles published in Blood. Dr. Zoller discusses "Ferric Carboxymaltose Increases Fracture Risk in Patients and Reduces Bone Formation in Mice with Iron Deficiency Anemia", and how these findings support consideration of alternative IV iron formulations that provide similar efficacy without risk of skeletal complications.  Dr. Ribeiro discusses "A low-versus standard-dose regimen an induction for AML: a multicenter, randomized noninferiority trial" and how the low-dose regimen is associated with fewer toxicities, faster hematologic recovery, and reduced health care costs, suggesting a feasible treatment strategy for resource-limited settings.

The Steam Machine has finally been released, and if it wasn't for the price of RAM it would probably sound a lot better. But make sure you save some money for GTA6 because ouch.Scientists have discovered a cluster of neurons in mice that cause them to have ADHD. It could lead to a permanent treatment for ADHD, which is pretty exciting.Critics think Anime is becoming commoditized. What does that even mean? Who cares?***We enjoyed a nice drink of Rez which you can get a 10% discount when you type NERDS at the checkout from the Rez website at www.drinkrez.com ***Resources MentionedAll the news from the Steam Machine and GTA 6 ("This is going to be a niche device" – Analysts react to the $1,000+ Steam Machine price reveal | GamesIndustry.biz, GTA 6 - all you need to know about Rockstar's blockbuster game, Rockstar Games Responds to GTA 6 Physical Disc Backlash)ADHD Mice (Scientists discover ancient brain cells that help block distractions | ScienceDaily, Evolutionarily old brainstem neurons are required for the control of selective spatial attention | Nature Communications )Anime as a commodity (Anime's growing commoditization could lead to a future where the medium itself no longer matters, Japanese critic warns - AUTOMATON WEST)Full Show Notes : https://docs.google.com/document/d/1KoEtH9hnCRRr48QCYGDmIE_tIeKrLoK3oWGw9ZcAWMw/edit?usp=sharing***If you'd like to be featured on the show, send us an email: Nerds.Amalgamated@gmail.comFollow us on: Facebook || Twitter || TwitchJoin the Community on Discord: https://discord.gg/cb9G4sVCPkAnd watch us on YouTube: Nerds Amalgamated - YouTube

Its a fun one this week as we bring in an honorary amigo Kieran Squires (The Drycleaner) to talk about a raft of fun comic topics. From a big comic mart discussion, to underused heroes that deserve a spotlight to those popular creators that we just don't get, its an absolutely jam packed comics chat that guaranteed to get you jumping online to read comics or just let us know what you think! Great stuff to check out: Kieran Squires, London Comic Mart, Kellys Comic Fair, Mega City Book Club, Inkblot Festival, Three Planes, Roger Mason, The Mice, Commando, The Cannibals, Field Mouse Press, Noir City Murders, Green Archer Comics, The Saint, Rebellion, ABC Warriors, Rising Stars, J Michael Straszinski, Rising Stars: Visitations, Vanguard, Dan Butcher, XMen: Elsewhen, Periodical, Durin, Rachael Ball

On this episode we have on David Reminick from Paper Mice and his new kids band DadJoke.We talked about food, loving to cook, some of our favorite things to cook or eat, therapy, ADHD, learning to prioritize yourself, trying new things and challenging yourself, being nicer to yourself, what life lessons you teach your kids,  what you unlearn when you become a parent, his time in Paper Mice and his experience make music for kids as DadJoke, and realizing you've added way too many layers to a kids song.Make sure to go to dadjokemusic.com to find the music!  DadJoke is weird music for weird kids and extremely creative, silly, and fun.Send us Fan MailFollow us on Facebook and Instagram and TikTok YouTube. Look for new episodes of The Imperfect Dads Podcast every Monday and Thursday.This podcast is part of the Never A Phase Network, follow them on instagram at @neveraphasenetwork and check out their podcasts like Emo Kids Anonymous  Wasting Time Podcast Certified Fangirl and The Ska Mailman

Broadcast from KSQD, Santa Cruz on 6-25-2026: Dr. Dawn devotes the show's opening to ivermectin for COVID. She walks through critical thinking principles—considering the source, cross-verification, and recognizing self-interested claims—before reviewing the evidence. The most-cited 2021 Bulgarian study of 300 people showing 77% reduction lacked accessible methods, and larger trials capable of detecting even small benefits failed to confirm efficacy. On safety, the standard 12mg parasitic dose every few weeks is well-tolerated due to the blood-brain barrier and efflux pumps that keep ivermectin out of the brain, but daily long-term dosing has caused encephalopathy, liver and kidney damage, and birth defects. Critical drug interactions—macrolide antibiotics, verapamil, proton pump inhibitors, and beta blockers—disable the efflux mechanism, and high-fat meals increase absorption 2.5-fold. Dr. Dawn shares two inflammation formulas calculable from any CBC. The Systemic Inflammatory Index (neutrophils × platelets ÷ lymphocytes) flags runaway inflammation: 200-500 is good, above 900 warrants investigation and correlates with worse stroke outcomes and rising tumor burden. The SIRI (neutrophils x monocytes ÷ lymphocytes) detects chronic tissue inflammation and early innate immune activation: below 500 is good, above 1500 indicates trouble and correlates with cardiovascular mortality and arterial plaque from M1 macrophage activity. Dr. Dawn shares two takeaways from the Institute for Functional Medicine annual conference: in patients at high cardiovascular risk by cholesterol, each gram daily of combined EPA/DHA produces a 9% risk reduction, with bruising as the dose-limit signal. Additionally, a 15-minute walk within 30 minutes of a meal nearly eliminates postprandial inflammation. An emailer asks whether an endocrinologist's claim that vitamin D leaches calcium from bones is true. Dr. Dawn confirms that very high vitamin D (above 150 nanograms, with concern starting above 90) elevates 1,25-vitamin D, which stimulates osteoclast formation and increases C-telopeptide markers of bone breakdown. A crowdsourced question asks how histamines work in women. Dr. Dawn explains histamine functions as a CNS neurotransmitter promoting alertness, wakefulness, and pain perception (deficient in narcolepsy), and as a GI signal driving acid secretion, motility, and visceral sensation. Gut bacteria can convert histidine to histamine, and fish left to spoil can trigger anaphylactic-like reactions from accumulated bacterial histamine. She notes stomach acid treatments Tagamet and Zantac are H2 blockers rather than the more familiar H1 antihistamines, and confirms histamine correlates with hormones but not particularly with minerals. A crowdsourced question on B vitamins for women in their mid-twenties prompts Dr. Dawn to recommend prenatal vitamins for those who might become pregnant, and B100 complex with calcium taken with a little apple cider vinegar for those on restricted diets or eating mostly fast food. Another question asks about chest versus belly breathing. Dr. Dawn explains babies demonstrate proper diaphragmatic breathing (belly protrudes on inhalation) while accessory muscle use signals fight-or-flight—or pneumonia in a non-crying infant. Chest breathing raises adrenaline; belly breathing calms it in adults. How do I stop compulsive scratching? Dr. Dawn explains neurodermatitis has its own ICD-10 code alongside compulsive nail-biting and hair-pulling, and it is diagnosed by sparing of unreachable areas like the mid-back between shoulder blades. Treatment includes nail clipping, lubricants, covering scabbed areas, and Prozac—which uniquely among antidepressants has a secondary indication for neurodermatitis. Zurich researchers combined immature human nerve cells with magnetic nanoparticles to create 6-micrometer NPC bots that can be magnetically positioned at spinal cord injury sites and then triggered by pulsatile magnetic stimulation to mature into nerve tissue. Mice with severed spinal cords regained movement and brain-muscle electrical signals by day 34 after daily 30-minute treatments. A study of 15,000 people with myalgic encephalomyelitis/chronic fatigue syndrome identified eight genetic regions distinguishing them from controls. Two relate to immune response to infection—consistent with the post-infectious onset many sufferers describe, including roughly half of long COVID patients—and others link to the nervous system and chronic pain. Dr. Dawn frames ME-CFS as an immune system stuck in the "on" position, unable to brake against an enemy that is long gone. An emailer asks about prostate biopsy approaches. Dr. Dawn explains the new transperineal biopsy (through skin between scrotum and anus) reduces post-biopsy infection from 1.5% to near zero and eliminates prophylactic antibiotics, though it requires more anesthesia and time. Cancer detection rates match the transrectal approach when both use MRI targeting, and she expects the transperineal approach to become standard.

In this episode of Reading With Your Kids, we're celebrating humor, heart, and the power of picture books to bring families together. Most of our time is spent with Ann Koffsky, author of Blazing Humor: Mel Brooks Is Seriously Funny. Ann and Jed dive into why Mel Brooks' comedy, while very much for adults, still offers a powerful, kid-friendly life story. Ann talks about the challenge of sharing a famously edgy comedian with young readers—focusing not on the racy jokes, but on Mel's resilience, his use of humor to face bullies, racism, and hard times, and his joyful Jewish identity. She describes curating a YouTube playlist of kid-appropriate Mel Brooks clips and reflects on how picture books might be one of the last truly shared media experiences for grown-ups and kids. Together, they explore how humor can be a survival skill in an angry, algorithm-driven world. Next, Evelina Ruimy joins the show to introduce The Kind Bunny, the first in her Hops Tales series. Written during a frightening wildfire evacuation, the book helps families talk about unkind words, hurt feelings, and why kindness begins with how we treat ourselves. Evelina shares how Bunny chooses to answer rudeness with kindness, turning conflict into friendship, and how parents can use the story to start meaningful conversations about bullying and self-worth. Finally, Bob Richley stops by to chat about Redeeming Rhubarb, a middle-grade novel about a mouse, a rat, and what it really means to love your enemies—even when you've been taught to hate them.

Fish Oil Supplements And Alzheimer's-Related Decline A two-year randomized, double-blind, placebo-controlled trial led by researchers at USC tested whether 2,000 mg of DHA fish oil daily could slow Alzheimer's-related brain changes in 365 adults ages 55–80 who rarely consumed fish and had at least one Alzheimer's risk factor. Researchers confirmed the supplement reached the brain by measuring a roughly 17% increase in cerebrospinal fluid DHA after six months. Despite successfully increasing brain DHA levels, participants taking fish oil showed no significant improvements in memory, global cognitive function, or hippocampal volume compared to placebo after two years. Host Dave Asprey explains why raising a single biomarker doesn't always translate into better brain performance, why nutrition works differently inside a complete dietary pattern than as an isolated supplement, and what this study means for anyone relying on fish oil as an Alzheimer's prevention strategy. Sources: https://medicalxpress.com/news/2026-06-fish-oil-supplements-alzheimer-decline.pdf https://www.cnn.com/2026/06/18/health/omega-3-fish-oil-algae-supplement-wellness ~~ DASH Diet Showed the Strongest Link to Long-Term Brain Health Researchers from Harvard analyzed dietary data from 159,347 participants across three long-running U.S. health studies to examine how eating patterns influence cognitive aging. Participants completed dietary questionnaires every four years over several decades, allowing investigators to compare six healthy dietary patterns, including the DASH and Mediterranean diets. While all six were associated with better cognitive health later in life, adherence to the DASH diet produced the strongest association, with participants showing roughly a 40% lower risk of subjective cognitive decline and stronger performance on objective cognitive testing. The protective relationship was strongest when healthy eating habits began during midlife. Host Dave Asprey breaks down why blood sugar control, lower inflammation, and healthier blood vessels may be the real drivers behind long-term brain resilience, and why your dietary choices in your 40s and 50s may have an outsized impact on cognitive aging decades later. Sources: https://jamanetwork.com/journals/jamaneurology/article-abstract/2845466 https://www.health.harvard.edu/diet-and-nutrition/harvard-study-six-healthy-diets-linked-with-better-long-term-brain-health https://www.eurekalert.org/news-releases/1117225 ~~ Scientists Identified an Ancient Brain Circuit That Filters Distractions Johns Hopkins researchers discovered a small population of inhibitory neurons within an evolutionarily ancient brainstem region that appears to control selective attention by determining which sensory information deserves focus and which distractions should be ignored. Mice trained on visual attention tasks consistently ignored irrelevant stimuli until researchers temporarily silenced these neurons, causing even weak distractions to hijack their attention while leaving vision and movement otherwise unaffected. Similar brain circuits exist in birds, reptiles, and other vertebrates, suggesting this attentional filtering system evolved long before the modern human cortex. Host Dave Asprey explains why attention may depend on much older brain circuitry than previously believed, how this discovery could reshape our understanding of ADHD and autism, and why future therapies may target the brainstem instead of the prefrontal cortex. Sources: https://www.sciencedaily.com/releases/2026/06/260624025426.htm ~~ Nearly Half of Older Adults Improved With Age Instead of Declining A Yale-led study followed 11,340 adults age 65 and older for up to 12 years using repeated measurements of cognition and walking speed to better understand how aging changes over time. Rather than finding universal decline, researchers discovered that 45% of participants improved in either cognitive function, physical performance, or both. Nearly one-third experienced measurable cognitive improvements, while over one-quarter improved physically. Researchers also found that participants with more positive beliefs about aging were significantly more likely to improve, even after accounting for education, chronic illness, depression, and other health factors. Host Dave Asprey explores why expectations about aging may become biologically embedded, why decline is far less inevitable than conventional medicine often assumes, and how mindset may directly influence healthy longevity. Sources: https://www.sciencedaily.com/releases/2026/06/260620100428.htm ~~ Glyphosate May Be Contributing to Antibiotic-Resistant Superbugs Researchers publishing in Frontiers in Microbiology examined 102 bacterial strains collected from hospitals, agricultural land, and protected wetlands to investigate whether glyphosate exposure contributes to multidrug antibiotic resistance. Hospital bacteria demonstrated extensive resistance to both antibiotics and glyphosate, while even bacteria living inside protected nature reserves displayed measurable glyphosate resistance despite no direct herbicide application. Genetic analysis suggested resistant bacterial strains may move between agricultural environments and hospitals through shared waterways and sediments. The researchers argue pesticide safety testing should also evaluate whether chemicals encourage antibiotic resistance, one of the world's fastest-growing public health threats. Host Dave Asprey explains why environmental toxins may have unintended effects on the human microbiome, how herbicides could influence antimicrobial resistance beyond farming, and why environmental biology increasingly belongs in conversations about human health. Sources: https://www.sciencedaily.com/releases/2026/06/260620100434.htm https://www.openaccessgovernment.org/common-weedkiller-glyphosate-linked-to-rise-in-superbugs-scientists-warn/207515/ ~~ Butterflies That Barely Age Could Unlock New Longevity Pathways Researchers from the University of Bristol found that Heliconius butterflies live dramatically longer than closely related butterfly species while aging much more slowly. In one comparison, Heliconius hewitsoni survived up to 348 days, while a closely related species lived only 14 days. Unlike most butterflies, Heliconius feed on pollen throughout adulthood, providing amino acids that help preserve muscle function and physical performance with age. However, even when pollen was removed, these butterflies still significantly outlived their relatives, suggesting evolved genetic and metabolic mechanisms also contribute to their exceptional longevity. Host Dave Asprey explores why nature continues to provide unexpected models for slowing biological aging, what scientists hope to learn from species that naturally maintain function over time, and how comparative biology may uncover entirely new pathways for extending human healthspan. Sources: https://www.sciencedaily.com/releases/2026/06/260622014302.htm ~~ This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want mechanism-level insights into omega-3 supplementation and Alzheimer's prevention, nutrition strategies for preserving cognitive health, newly discovered brain circuits controlling attention, the surprising biology behind healthy aging, environmental drivers of antibiotic resistance, and what one remarkably long-lived butterfly can teach us about extending healthspan. Host Dave Asprey connects randomized clinical trials, large population studies, neuroscience discoveries, microbiology research, and evolutionary biology into practical frameworks for improving brain performance, resilience, and longevity. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: fish oil Alzheimer's study, DHA supplements memory, omega-3 brain health, DASH diet cognition, dementia prevention diet, cognitive decline nutrition, selective attention brainstem, focus neuroscience, ADHD brain research, positive aging beliefs, healthy aging study, cognitive improvement older adults, glyphosate antibiotic resistance, superbugs glyphosate, environmental toxins microbiome, butterfly longevity research, Heliconius aging, longevity science, biohacking news 2026, Dave Asprey, The Human Upgrade Thank you to our sponsors! - Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today - Neuronic | Go to www.neuronic.online Code DAVE for $100 off - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:18 – Story #1 Fish Oil 02:31 – Story #2 DASH Diet 03:49 – Story #3 Brain Stem Attention Filter 05:59 – Story #4 Cognitive Decline Lies 08:24 – Story #5 Glyphosate 10:16 – Story #6 Butterfly Lifespan Research 12:16 – Biohacking Criticism Response See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The same glucosamine pill millions take for joint pain may protect a healthy brain — and accelerate Alzheimer's in a brain already in decline. Here's the science.In this episode of Health Longevity Secrets, Robert Lufkin MD breaks down the 2026 plot twist on glucosamine and dementia: why a supplement once hailed as a longevity hack now carries an Alzheimer's warning, and why the answer comes down to one thing — the state of your metabolism. The same molecule helped the metabolically healthy and may have harmed the metabolically broken. The supplement didn't change; the soil it landed on did.Chapters:00:00 — Introduction00:39 — The Supplement Everyone Trusted01:06 — UK Biobank: Glucosamine and 15% Lower Death Risk01:38 — Why Glucosamine Looked Like a Longevity Hack02:48 — The 2026 Plot Twist: Nature Metabolism Study03:53 — Alzheimer's Mice and the Glucosamine Pathway04:13 — How Sugar Tagging (Glycosylation) Explains Both04:57 — Hyperglycosylation in the Alzheimer's Brain05:34 — The Honest Caveat: Association vs Causation06:55 — The Takeaway: Metabolic Health Decides EverythingKey takeaways:In healthy, cognitively normal adults, regular glucosamine use has been tied to lower all-cause mortality and lower risk of dementia — especially vascular dementia.A June 2026 University of Florida study in Nature Metabolism found the opposite signal in sick brains: in people with mild cognitive impairment, glucosamine use was associated with a 25% higher likelihood of progressing to Alzheimer's, and a 25% higher death risk in those already diagnosed.In Alzheimer's mice, glucosamine made memory worse; blocking the same sugar-tagging pathway made it better.The mechanism is metabolic: glucosamine feeds glycosylation (sugar-tagging of proteins). A healthy brain handles it fine; an Alzheimer's brain is already hyperglycosylated, so adding more is "pouring gasoline on the fire."This is association, not proof of cause — and the literature is genuinely mixed. If you're healthy, it's not a fire alarm. If you or a loved one has MCI or dementia, talk to your physician before the next refill.Studies & sources:Hawkinson et al., "Hyperglycosylation is a metabolic driver of Alzheimer's disease," Nature Metabolism 2026 (University of Florida)University of Florida news release on the glucosamine–dementia findingZheng et al., "Association of regular glucosamine use with incident dementia," BMC Medicine 2023 (UK Biobank)Habitual glucosamine use, APOE genotypes, and cause-specific dementia in older adults (UK Biobank)Li et al., "Associations of regular glucosamine use with all-cause and cause-specific mortality," Annals of the Rheumatic Diseases 2020 (UK Biobank)Read Dr. Lufkin's book "Lies I Taught in Medical School".⭐ Enjoying the show? Please leave a 5-star review on Apple Podcasts — it takes 30 seconds and helps more people discover the science of health and longevity. Thank you!New episodes every Tuesday & Thursday. Subscribe so you don't miss one.Continue this conversation on Substack: https://robertlufkinmd.substack.comLies I Taught In Medical School — Free sample chapter: https://www.robertlufkinmd.com/lies/Web: https://www.robertlufkinmd.comYouTube: https://www.youtube.com/robertlufkinmdX: https://x.com/robertlufkinmdInstagram: https://www.instagram.com/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinLinkedIn: https://www.linkedin.com/in/robertlufkinmd/

The World Cup is here, and while we watch some of the world's greatest athletes competing on a global stage, it's fascinating to consider what effect this intense activity may have on the human body. With that in mind, we're re-releasing our conversation with Stanford biochemist Jonathan Long on the future of exercise. Jonathan studies the chemistry of what happens inside your body when you move, and his findings are pointing toward some genuinely surprising possibilities — including treatments for obesity, diabetes, and even, someday, an exercise pill. If the athleticism on the pitch has you feeling inspired, this one is well worth another listen. Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your question. You can send questions to thefutureofeverything@stanford.edu. Episode Reference Links: Stanford Profile: Jonathan Long Connect With Us: Episode Transcripts >>> The Future of Everything Website Connect with Russ >>> Threads / Bluesky / Mastodon Connect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / Facebook Chapters: (00:00:00) Introduction Russ Altman introduces guest Jonathan Long, a professor of pathology from Stanford University. (00:02:02) Effective Weight Loss Drugs The history and development of GLP-1 receptor agonists. (00:04:04) Understanding Metabolism and Exercise Why Long's lab starts with molecules to understand metabolism and physical activity. (00:05:10) Animal Models in Exercise Studies The use of animal models in exercise studies and the discovery of Lac-Phe. (00:06:47) Psychological Preparation for Exercise The psychological aspects of exercise and the involvement of endocannabinoids in exercise motivation. (00:09:00) Lac-Phe's Role and Mechanism The role of Lac-Phe and its production in the gut. (00:12:08) Differences in Exercise Response Differences in exercise response between trained athletes and untrained individuals. (00:12:57) Diabetes and Metabolic Diseases The relationship between diabetes, exercise, and metabolic diseases. (00:15:01) Lac-Phe as a Potential Therapeutic The potential of Lac-Phe as a weight loss drug, and parallels to GLP-1 drug development. (00:16:21) Importance of How Weight is Lost Whether the method of weight loss matters, and the importance of preserving lean muscle mass. (00:18:37) Exercise as Medicine The concept of exercise as medicine, and defining physical activity at the same resolution as modern medicines. (00:22:11) Metformin and Exercise Pathways The unexpected connection between metformin and the Lac-Phe pathway. (00:24:01) Prospects of an Exercise Pill The future of an exercise pill, and the challenges associated with its development. (00:27:05) Conclusion Final thoughts on the future of exercise. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Deep beneath the world, on the one anniversary night nobody expected, a tiny, tired song drifts up from a tunnel no one has ever dared to follow.

This week on the Roach Koach Podcast, Lorin and Matt celebrate the week of Roach Koach X by listening to some (fairly) new Nu with Of Mice & Men's 2014 album, Restoring Force. Topics this episode include:-Final push for Roach Koach X tickets!-Metalcore band line up changes-The trials of unclean vocalists-Good reviews-Changing your screams-“This riff is hard”-Going to jail for a fan-“You hear the screaming, we hear the meaning”-Public Service announcements-The hardest four years of your life-“If I could fuck the world”?-22 second screams-And Canon Talk, where Lorin and Matt decide if Of Mice & Men get a place in the Nu-Metal Canon.Take a listen!Roach Koach X is almost here! June 20th at Go Comedy Improv Theater in Ferndale Michigan. Tickets now on sale!

This week we talk about the negative consequences of invasive species. Music Provided By: Greg Gibbs / Most Guitars Are Made of Trees Winston / Valse Catastrophe

Yakov Turgenev, the world's tallest and best-looking Russian Parking Attendant, faces off against the violent, masked men who are, frankly, more like MICE.

Elis is fresh from the jolly japes of being surprised with being made to do a headline set in front of 5,000 people at an iconic venue. He's just soooo totally cool about it.“Feel free to leave if it's bad, but give the guy a chance.” So if you want to miss the rush during the gig then stay til the end. John revives an old, and at times deeply criticised, feature. We also hear some more good old fashioned Common Zense, which helps us ask the question, if the Dalai Lama spilt coffee on an important letter would he be calm?Got any parabulation to send in? Well send it on the calm winds to hello@elisandjohn.comAnd please stick around til the end of the show.For more information on Pressure is a Privilege head here. And it's here for Don't Think So Somehow, and here for Skinwigs.For lots of exclusive EJJR #content, join our Patreon at patreon.com/elisandjohn.For weekly visual highlights, head to youtube.com/@elisandjohn.For everything else, head to elisandjohn.com.The Elis James and John Robins Show is a Significant Production. Hosted on Acast. See acast.com/privacy for more information.

Show Notes On this week's podcast, Dan and Kris recap the first batch of Not-E3 showcases, including Summer Game Fest, and one heck of a PlayStation State of Play. What big game announcements were made? How many forgettable indie showcases were there? Let's find out! Then, in Week Old News, Yacht Club Games is safe… for now, Vampire Survivors gets wet, there's a new more affordable Morph on the way, Nintendo crosses over with Crocs, and more! Finally, in the Checkpoint, Kris gives the skinny on Bubsy 4D, but isn't super hot on Mina the Hollower. Meanwhile Dan also played Mina the Hollower and enjoyed it a bit more, shows his kids friends what's what in Marvel vs. Capcom, and more! Enjoy! See Our Faces!!! Stone Age Gamer YouTube Just Hear Our Voices Audio only version Useful Links Support us on Patreon StoneAgeGamer.com The Gratuitous Rainbow Spectrum Safe at Home Rescue Shoot the Moon Stitches Art of Angela Nintendo Force Magazine SAG's theme Song “Squared Roots” by Banjo Guy Ollie Break Music Wolverine - Title and Ending Theme Cameltry - Message Yo! Noid - Skating Rooftop Bubsy 4D - Wooltopia Social Stuff Join us on Discord! Twitch Geekade Facebook Stone Age Gamer Facebook Geekade Twitter Stone Age Gamer Twitter Geekade Instagram Stone Age Gamer Instagram YouTube Geekade Contact Us

Thanks to Smirnoff Ice, we welcome you back to another ad-free episode of Upstairs Neighbors! This week Dom and Maya talk about their vacation trips while away, an abundance mindset, and the potential condemnation of their favorite restaurant... Remy get cooking! Enjoy! *Drink Responsibly, 21+ Podcast Socials: IG: https://www.instagram.com/upstairsneighborspod/ TikTok: https://www.tiktok.com/@upstairsneighborspod Follow our Hosts: Maya IG: https://www.instagram.com/mayamoto_/ Maya TikTok: https://www.tiktok.com/@mayahasatiktok Dom IG: https://www.instagram.com/domrobxrts/ Dom TikTok: https://www.tiktok.com/@domnotateenmom Learn more about your ad choices. Visit megaphone.fm/adchoices

BUFFALO, NY — June 10, 2026 — A new #research paper was #published in Volume 18 of Aging on May 18, 2026, titled “Transcriptional programs diverge in aging mouse and human skeletal muscle.” The study was led by co-first authors Charles D. Hwang and Siti Rahmayanti and corresponding author Indranil Sinha from Brigham and Women's Hospital, Harvard University. Aging is widely associated with the gradual loss of muscle mass, strength, and physical function. Much of what scientists know about these changes comes from studies in laboratory mice, which are frequently used to investigate the biological mechanisms of aging and to identify potential therapeutic targets. However, an important question remains: how closely do aging-related changes in mouse muscle reflect what actually occurs in humans? To address this question, researchers performed a detailed comparison of gene expression patterns in skeletal muscle from young and old mice and humans. The team analyzed RNA sequencing data from mouse gastrocnemius muscle and compared it with transcriptomic data from healthy young and older adults obtained through the National Institute on Aging's GESTALT study. The results revealed substantial differences between the two species. Despite both mice and humans experiencing age-related muscle decline, fewer than 5% of significantly altered biological pathways were shared between them. Many of the genetic programs that changed with aging in mice showed little resemblance to those observed in human skeletal muscle. Full press release - https://aging-us.net/2026/06/10/aging-muscle-follows-different-genetic-programs-in-mice-and-humans/ DOI - https://doi.org/10.18632/aging.206382 Corresponding author - Indranil Sinha - isinha@bwh.harvard.edu Abstract video - https://www.youtube.com/watch?v=CYKh4X1w8H0 Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206382 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - hypoxia, angiogenesis, aging, skeletal muscle, regeneration To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

The Prince of Darkness is going digital, and the Osbourne family is fighting back. In today's Daily Metal Breakdown, we dive deep into the massive internet controversy surrounding the newly announced interactive Ozzy Osbourne AI avatar. We unmask the explosive defense from Sharon and Jack Osbourne on their family podcast as they silence critics labeling the project a "cash grab." Plus, a devastating summer tour cancellation from Of Mice & Men, and a major soundtrack update for EA's highly anticipated Skate video game featuring August Burns Red and Bad Brains. What You'll Hear in This Episode: The Terminator Defense: Jack Osbourne breaks down the "closed loop" technology powering the late summer 2026 launch of the life-sized Proto Luma Ozzy hologram. Sharon Fires Back: Why Sharon Osbourne is completely defying the internet court of public opinion over protecting Ozzy's long-term legacy for his grandkids. Of Mice & Men Tour Left Stranded: The sudden, heartbreaking cancellation of the band's highly anticipated European summer tour alongside Vended and Unearth. Shredding the Virtual Streets: Electronic Arts drops the official tracklist additions for Skate Season 4, infusing heavy metalcore and hardcore punk into the gaming landscape. Get More Loaded Radio: ⚡ Visit the Command Center: Head over to loadedradio.com for 24/7 breaking rock and metal journalism, tour itineraries, and exclusive features.

Sony, Xbox, and Summer Game Fest brought enough trailers to destroy my backlog, so let's break it down a bit, talk Halo, Insomniac's Wolverine and meltdown over Marvel Rivals for a sec. . NERDSoul.DÉCKOR Geek Wall Art https://www.etsy.com/shop/NERDSoulDeckor Gamepads, Mice, Keyboards, Arcade Sticks, Typewriters, whatever... LFG! Starring: Blerdish: https://linktr.ee/blerd.ish Open Mynd: https://bsky.app/profile/openmynd.bsky.social TJ Storm: PSN - TJStorm For: http://patreon.com/ThatNERDSoul | CashApp: $nerdsoul From: https://nerdsoul.myspreadshop.com From: https://nerdsoul.podbean.com  

Niléane has a cool new mouse, Matt wants to reflect on what they've learned shipping apps to the public, and they both reflect on joining cults. This week's Cozy Zone, we had to guess and then tier list Google's dead apps. Want more from the gang? Cozy Zone is a bonus podcast every Monday where we let loose on all sorts of fun topics. You can get cozy with the Comfort Zone crew for just $5/month or $50/year, which not only makes the bonus episodes possible, but supports Comfort Zone, too. How would you have done our challenges? How would you answer the question at the end of the show? Let us know! Things discussed Here's what I use my Apple Newton for in 2023 RAD Weather Keychron M6 MOS for Mac Quick Reads TinyStart Bevel Bevel 3.0 announcement video Follow the Hosts Chris on YouTube Matt on Birchtree Niléane on Mastodon Comfort Zone on Mastodon Comfort Zone on Bluesky

This week we decided to watch another classic Don Bluth cartoon about attractive mice. We all watched The Secret of NIMH, a fantasy children's movie about a single mom trying to get medicine for her sick son. Tune in next week when our movie will be... The Bodyguard. ----- THE STINGTONES ARE HERE! Please click this link and enjoy our library of stings. Come see Jordan June 6-7 at TCAF the Toronto Comics Art Festival You should buy Predator: Bloodshed and do so at Bookshop.org! The Predator: Bloodshed collection is coming out on Nov 24th. Be sure to pre-order it here at Bookshop.org. Help support this show and unlock bonus content! Become a member at https://maximumfun.org/joinfreewithads

After Ashlee hears a story about a guy who has a Disney themed room, a Star Wars Themed room and a beach themed room, she wants to know the crazy things you've seen in someone else's house.See omnystudio.com/listener for privacy information.

BUFFALO, NY – June 2, 2026 – A new #research paper was #published in Volume 17 of Oncotarget on May 20, 2026, titled “Microenvironmental CTHRC1 has a pro-tumorigenic role in colorectal cancer.” The study was led by first author Haylee Duval from the Center for Molecular Medicine at the MaineHealth Institute for Research and the Graduate School of Biomedical Science and Engineering at the University of Maine. The study's corresponding authors were Sergey Ryzhov, Volkhard Lindner, and Michaela R. Reagan, who are affiliated with the Center for Molecular Medicine at the MaineHealth Institute for Research, the Graduate School of Biomedical Science and Engineering at the University of Maine, and Tufts University School of Medicine. Colorectal cancer remains one of the leading causes of cancer-related deaths worldwide. While much research has focused on cancer cells themselves, growing evidence suggests that the tumor microenvironment—the network of surrounding stromal cells, immune cells, and extracellular components—plays a critical role in determining how tumors grow and spread. In this study, researchers investigated collagen triple helix repeat containing 1 (CTHRC1), a secreted protein previously associated with poor outcomes in several cancer types. Although CTHRC1 is frequently detected in tumor-associated stroma, its precise role within the colorectal cancer microenvironment has remained unclear. To address this question, the team used a genetically engineered mouse model lacking CTHRC1 and compared tumor development with that of normal mice after colorectal cancer cells were introduced. The results consistently showed that the absence of host-derived CTHRC1 significantly reduced tumor growth. Across three independent experimental cohorts, mice lacking CTHRC1 developed substantially smaller tumors than their normal counterparts. In addition, survival improved markedly. The median survival of mice with normal CTHRC1 expression was 28 days after tumor inoculation, compared with 69 days in CTHRC1-deficient mice. The researchers also found evidence that CTHRC1 influences anti-tumor immunity. Mice lacking CTHRC1 had higher percentages of CD3-positive T cells in both tumors and spleens, suggesting a more active immune response against cancer. At the same time, they exhibited reduced levels of certain myeloid immune cells associated with immune suppression. Importantly, the investigators confirmed that the colorectal cancer cells themselves did not produce detectable CTHRC1. Instead, the protein was found primarily in fibroblasts and other stromal components surrounding the tumor. This finding indicates that the tumor-promoting effects originated from the tumor microenvironment rather than from the cancer cells directly. Histological analyses further revealed striking differences in tumor structure. Tumors from CTHRC1-deficient mice contained fewer cells and showed evidence of regression, while tumors in normal mice remained densely cellular and continued to expand. Full press release - https://www.oncotarget.com/news/pr/protein-in-tumor-microenvironment-found-to-promote-colorectal-cancer-growth-and-immune-evasion/ DOI - https://doi.org/10.18632/oncotarget.28878 Correspondence to: Sergey Ryzhov - Sergey.Ryzhov@mainehealth.org; Volkhard Lindner- Volkhard.Lindner@mainehealth.org; Michaela R. Reagan - Michaela.Reagan@mainehealth.org Abstract video - https://www.youtube.com/watch?v=gTbYy6vGd7E To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

She's one of the best writers on science today, combining optimism about progress with a realist understanding of the messiness of our world. Saloni Dattani joins Amit Varma in episode 445 of The Seen and the Unseen to discuss science, medicine, data, academia and how to make the world a better place. (FOR FULL LINKED SHOW NOTES, GO TO SEENUNSEEN.IN.)   Also check out: 1. Saloni Dattani at Google Scholar, Twitter, LinkedIn, Our World in Data and Works in Progress. 2. Scientific Discovery -- Saloni Dattani's newsletter. 3. Hard Drugs -- Saloni Dattani's podcast. 4. Saloni's guide to data visualization -- Saloni Dattani. 5. Four charts to understand causes of death across the lifespan -- Saloni Dattani. 6. What I've learnt about writing -- Saloni Dattani. 7. In praise of the Covid superforecasters -- Saloni Dattani. 8. The decline in cancer mortality is about much more than smoking -- Saloni Dattani. 9. Death rates from cardiovascular disease have fallen dramatically — what were the breakthroughs behind this? -- Saloni Dattani. 10. The golden age of vaccine development -- Saloni Dattani. 11. Why we didn't get a malaria vaccine sooner -- Saloni Dattani. 12. The first cancer vaccine -- Transcript of a Hard Drugs episode. 13. Measles vaccines save millions of lives each year -- Saloni Dattani. 14. Why the total fertility rate doesn't necessarily tell us the number of births women eventually have -- Saloni Dattani. 15. The rise in reported maternal mortality rates in the US is largely due to a change in measurement -- Saloni Dattani. 16. How do global statistics on suicide differ between sources? -- Saloni Dattani. 17. How many people die from snakebites? -- Saloni Dattani. 18. The Demographic and Health Surveys brought crucial data for more than 90 countries — without them, we risk darkness -- Saloni Dattani. 19. We don't have to sit back and just watch the horror unfold -- Saloni Dattani. 20. Childhood leukemia: how a deadly cancer became treatable -- Saloni Dattani. 21. Will AI solve medicine? -- Transcript of a Hard Drugs episode. 22. Real peer review has never been tried -- Saloni Dattani. 23. The speed of science -- Saloni Dattani. 24. Medical breakthroughs in 2025 -- Saloni Dattani. 25. Scientific progress is at risk of slowing down. Saloni Dattani is making sure it doesn't. -- Miranda Dixon-Luinenburg. 26. Innovation is not linear -- Jason Crawford. 27. Genentech: The Beginnings of Biotech -- Sally Smith Hughes. 28. Missing Markets for Innovation: Evidence from New Uses for Existing Drugs -- Eric Budish, Maya Durvasula, Benjamin Roin and Heidi Williams. 29. The 100% CI. 30. Superforecasting — Philip Tetlock and Dan Gardner. 31. How Long Do We Wait for New Inventions? -- Brian Potter. 32. Million Dollar Secret. 33. Woolly mice designed to engineer mammoth-like elephants -- Pallab Ghosh. 34. Age of Invention -- Anton Hause. 35. Million Death Study. 36. Science Fictions -- Stuart Ritchie. 37. Outliers -- Malcolm Gladwell. 38. Episodes of The Seen and the Unseen with Rukmini S: 1, 2, 3. 39. Fortress and Frontier in American Health Care — Robert Graboyes. 40. Strong Medicine -- Michael Kremer and Rachel Glennerster. 41. The Practice of Medicine — Episode 229 of The Seen and the Unseen (w Lancelot Pinto). 42. Project Resource Optimization. 43. Giving What We Can. 44. Coefficient Giving. 45. 1493 -- Charles Mann. 46. The Collapse -- Mary Elise Sarotte. 47. How to Survive a Plague -- David France. 48. The Mole. 49. And the Band Played On -- Randy Shilts. This episode is sponsored by The Six Percent Club. Join them to go from content idea to launch in just 45 days! Amit Varma runs a course called Life Lessons, which aims to be a launchpad towards learning essential life skills all of you need. For more details, and to sign up, click here. And have you read Amit's newsletter? Subscribe right away to The India Uncut Newsletter! It's free! Also check out Amit's online course, The Art of Clear Writing. Episode art: 'Salonium' by Simahina.

In today's episode, the rising rates of melanoma skin cancer in the UK - why is this happening? Also, evidence that pregnancy induces epigenetic changes to brain gene expression, researchers produce the world's first artificial bird egg to bring back the Dodo, and an electrical technique to discover the composition of the best coffee... Like this podcast? Please help us by supporting the Naked Scientists

394 Of Mice and Men (1939) w/Gregory MankOn this episode, Steven has the honor of having noted author and film historian, Gregory Mank, on to discuss 1939's Of Mice and Men! Mr. Mank has written numerous books. Please visit gregorymank.com to learn more about his work. I highly recommend all of his books!For more information about Monster Bash go to www.monsterbash.us.Please send feedback to DieCastMoviePodcast@gmail.com or leave us a message on our Facebook page.

https://wels2.blob.core.windows.net/daily-devotions/20260527dev.mp3 Listen to Devotion No one can say, “Jesus is Lord,” except by the Holy Spirit. 1 Corinthians 12:3 Life-Giver The camera pans over an old, abandoned farm truck that has been sitting in the woods for decades. Ivy covers it. Moss covers it. A small tree grows through a rusty hole. Mice have built a nest in the cab. And over the years, the wheels have settled into the dirt. But then along comes a cheerful backyard mechanic by the name of Derek Bieri. With basic tools and good-natured humor, Derek goes to work on the hulk sitting before him. Despite setbacks and disappointments, he patiently persists until the thrilling moment when the long-forgotten truck roars to life and comes out of the woods under its own power. This is the magic behind the wildly popular YouTube program entitled “Vice Grip Garage.” Each episode features a dead and forsaken car or truck that Derek manages to bring to life. One thing is for certain. These vehicles do not repair themselves. They start and run only because of Derek. By nature, I am far worse off than any rusted wreck left in the woods. Not only am I born spiritually dead, but my attitude towards the true God is downright hostile. On my own, I have no ability whatsoever to trust in Jesus as my Savior from sin. There’s a greater likelihood that a dead farm truck from “Vice Grip Garage” would bring itself to life and drive itself out of the woods. But that’s where the Lord comes in. Not only did he send his Son to become human and live a perfect life in my place. Not only did Jesus pay for my every sin through his death at Calvary’s cross, but he also raised himself from the grave. He has even sent God the Holy Spirit to bring my spiritually dead heart to life. Through the power of the Good News of Jesus, the Spirit has created within me the miracle of faith. And through this miraculous faith, I now receive full forgiveness, peace with God, and eternal life as my personal possessions. Giving life: There’s nothing the Holy Spirit enjoys more. Prayer: Holy Spirit, my heart was dead. But through your gospel you have brought me to life. Thank you. Amen. Daily Devotions is brought to you by WELS. This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License. All Scripture quotations, unless otherwise indicated, are taken from the Holy Bible, New International Version®, NIV®. Copyright ©1973, 1978, 1984, 2011 by Biblica, Inc. ™ Used by permission of Zondervan. All rights reserved worldwide.

https://wels2.blob.core.windows.net/daily-devotions/20260527dev.mp3 Listen to Devotion No one can say, “Jesus is Lord,” except by the Holy Spirit. 1 Corinthians 12:3 Life-Giver The camera pans over an old, abandoned farm truck that has been sitting in the woods for decades. Ivy covers it. Moss covers it. A small tree grows through a rusty hole. Mice have built a nest in the cab. And over the years, the wheels have settled into the dirt. But then along comes a cheerful backyard mechanic by the name of Derek Bieri. With basic tools and good-natured humor, Derek goes to work on the hulk sitting before him. Despite setbacks and disappointments, he patiently persists until the thrilling moment when the long-forgotten truck roars to life and comes out of the woods under its own power. This is the magic behind the wildly popular YouTube program entitled “Vice Grip Garage.” Each episode features a dead and forsaken car or truck that Derek manages to bring to life. One thing is for certain. These vehicles do not repair themselves. They start and run only because of Derek. By nature, I am far worse off than any rusted wreck left in the woods. Not only am I born spiritually dead, but my attitude towards the true God is downright hostile. On my own, I have no ability whatsoever to trust in Jesus as my Savior from sin. There’s a greater likelihood that a dead farm truck from “Vice Grip Garage” would bring itself to life and drive itself out of the woods. But that’s where the Lord comes in. Not only did he send his Son to become human and live a perfect life in my place. Not only did Jesus pay for my every sin through his death at Calvary’s cross, but he also raised himself from the grave. He has even sent God the Holy Spirit to bring my spiritually dead heart to life. Through the power of the Good News of Jesus, the Spirit has created within me the miracle of faith. And through this miraculous faith, I now receive full forgiveness, peace with God, and eternal life as my personal possessions. Giving life: There’s nothing the Holy Spirit enjoys more. Prayer: Holy Spirit, my heart was dead. But through your gospel you have brought me to life. Thank you. Amen. Daily Devotions is brought to you by WELS. This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 United States License. All Scripture quotations, unless otherwise indicated, are taken from the Holy Bible, New International Version®, NIV®. Copyright ©1973, 1978, 1984, 2011 by Biblica, Inc. ™ Used by permission of Zondervan. All rights reserved worldwide.

Jeremy Zakis details a burgeoning mouse plague in Western and South Australia, where mice are breeding rapidly and have become resilient to standard toxins. In response, the government has authorized farmers to double the dosage of zinc phosphide bait. This surge in prey has caused a corresponding increase in snake sightings, as predators forgo hibernation to feed. Most notably, a large red-bellied black snake was discovered living inside the walls of an emergency operating theater at John Hunter Hospital. Authorities were forced to close the theater to remove the snake, which had likely been eating local mice. (3/3)1899 PERTH WA

Jeremy Zakis details a burgeoning mouse plague in Western and South Australia, where mice are breeding rapidly and have become resilient to standard toxins. In response, the government has authorized farmers to double the dosage of zinc phosphide bait. This surge in prey has caused a corresponding increase in snake sightings, as predators forgo hibernation to feed. Most notably, a large red-bellied black snake was discovered living inside the walls of an emergency operating theater at John Hunter Hospital. Authorities were forced to close the theater to remove the snake, which had likely been eating local mice. (3/3)1927

In this episode, A.J. talks about George and Lennie and their unfortunate run-in with wannabe boxer.

We test a weird new toothbrush, fight ticks with Thermacell tubes, cool off with bladeless fans, and Chad reviews a monitor memo board.

Do ergonomic devices like split keyboards and vertical mice help with comfort and health?If you're a heavy computer user there are an increasing variety of weird and wonderful options to help improve your comfort and reduce the risk of aches and pains associated with 'Repetitive Strain Injury' (RSI).Listener Tim is curious whether ergonomic tools—such as split keyboards, alternative layouts, or vertical mice—could optimise his professional setup as a software engineer.To find out, presenter Greg Foot does a deep-dive into the evidence alongside Nichola Adams, from the Chartered Institute of Ergonomics and Human Factors; and Ben Vallack, who runs a YouTube channel all about workflow and design.And if you're interested in this topic, we have a companion episode on Standing Desks - available along with all our other episodes on BBC Sounds.All of our episodes start with YOUR suggestions. If you've seen an ad, trend or wonder product promising to make you happier, healthier or greener, email us at sliced.bread@bbc.co.uk OR send a voice note to our WhatsApp number, 07543 306807.RESEARCHER: PHIL SANSOM PRODUCERS: SIMON HOBAN AND GREG FOOT

TV NEWS: "Highway to Heaven" reboot, "Harry Potter" and "Reggie Dinkins" get renewals. PLUS, "False Prophets," "Hacks," and "Should I Marry a Murderer?" We celebrate El Burrito Mercado, singing and talking mice, and the best quote of the week from KeshaSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week, in Sidney, Montana, when a beloved local teacher disappears, after going for a morning run, all that's left behind is a running shoe, in a ditch. Luckily, a tip comes in that is very specific to one of the culprits. This tip leads to an unlikely pair, consisting of a large, dumb young man, and his smaller, craftier older friend. It seems that when the older man smokes a lot of crack he says "the devil gets in him", and this causes him to brutally murder a teacher, and also commit one of the dumbest acts that a murderer could ever think of!!   Along the way, we find out that way too many towns are named after small children, that 3 day crack benders rarely result in anything productive, and that you should never return a murder tool to the store, so you can get a refund!!   New episodes, every Wednesday & Friday nights!! Check us out on VIDEO Wednesday and Friday evenings on Netflix! www.netflix.com/smalltownmurder Donate at patreon.com/crimeinsports or at paypal.com and use our email: crimeinsports@gmail.com Go to shutupandgivememurder.com for all things Small Town Murder, Crime In Sports & Your Stupid Opinions!   Follow us on... instagram.com/smalltownmurder facebook.com/smalltownpod   Also, check out James & Jimmie's other shows, Crime In Sports & Your Stupid Opinions on Apple Podcasts, Spotify, or wherever you listen to podcasts!!

Hey, everybody! Tim, Kristen, and O'Dell  are back this week to talk about the upcoming release of Saros, the cartoon world of Mouse: P.I. for Hire, best convenience store snacks, and upcoming updates.

Dr. Marc Breedlove, PhD, is a professor of neuroscience at Michigan State University and an expert on how hormones shape brain development and sexual orientation. We discuss how prenatal testosterone impacts whether someone is romantically attracted to men or women later in life, and what correlates of sexual orientation — such as finger-length ratios — tell us about the role of hormones in brain and psychological development. We also discuss why the number of older brothers a male has biases sexual orientation. Throughout, we explain how nature and nurture interact to shape male-female differences, behavior, and romantic partner choice. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman Rorra: https://rorra.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00:00) Marc Breedlove (00:03:24) Hormones & Sexual Orientation (00:07:37) Prenatal Testosterone, Finger Ratio, Men & Women Differences (00:14:08) Sponsors: David & Rorra (00:16:46) Finger Ratios, Prenatal Testosterone, Gay & Straight Men/Women (00:23:57) Mice & Sex Differences, Androgens (00:26:54) Brain Differences & Sexual Orientation (00:33:52) Group vs Individual Differences, Height Analogy; Bisexuality (00:36:57) Brain Development, Hormones & Behavior; Brain Plasticity (00:42:52) Sponsor: AG1 (00:44:16) Sexual Behavior, Libido (00:51:37) Gay Rams, Brain Differences (00:58:00) Aversion Pathway, Men vs Women, Same-Sex Partner (01:06:58) Congenital Adrenal Hyperplasia (CAH), Intersex Phenotypes (01:13:55) Androgen Insensitivity Syndrome (AIS) (01:18:14) Sponsor: Function (01:19:25) Gay Men & Older Brothers, Maternal Immunization Hypothesis (01:32:55) CAH Carriers, Advantage, Stress Tolerance (01:35:41) Birds & Sexual Differentiation, Gynandromorphs (01:41:32) Anabolic Steroids, Hypersexuality; Adult Brain Plasticity (01:45:31) Age & Testosterone Decline; Sexual Orientation & Activities (01:53:14) Marc's Academic Journey, Ozarks, Luck (02:02:35) Exploration; Kids & Sex Differences (02:08:47) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices