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HEALTH NEWS Purslane Extract Tied to Improved Mood and Reduced Liver Stiffness in Trials, Researchers Say Natural Compound in Broccoli Could Help Treat a Rare, Incurable Neurological Disease Intermittent fasting reveals gut-brain pathway that may reduce chronic pain Microalga extract shows promise for fatigue through mitochondrial function Vitamin D Supplementation Tied to Slower Biological Aging, Studies Find Purslane Extract Tied to Improved Mood and Reduced Liver Stiffness in Trials, Researchers Say Mashhad University of Medical Sciences (Iran), August 21 2026 (Natural News) Purslane, a weed commonly found in garden beds and sidewalk cracks, has been linked in two clinical trials to improved mood and reduced liver stiffness. Purslane is an herbaceous succulent valued in many cultures for its vitamins, minerals, and antioxidants. A trial published in the journal Health Science Reports enrolled adults with nonalcoholic fatty liver disease. Participants received either purslane extract or a placebo in addition to regular care. The report said those who received purslane showed reductions in stress and low mood compared with the placebo group, and researchers said the results warrant further investigation. In 2024, the same research team published a trial of patients with nonalcoholic fatty liver disease received 700 milligrams of purslane extract daily for eight weeks. According to the study, liver stiffness decreased significantly compared with placebo, and the hepatorenal ultrasound index, a direct measure of fat buildup in the liver, also improved. Natural Compound in Broccoli Could Help Treat a Rare, Incurable Neurological Disease Swinburne University of Technology (Australia), August 21, 2026 (SciTech Daily) A naturally occurring compound in broccoli is being investigated as a possible treatment for Friedreich ataxia, a rare nervous system disease. Research from Swinburne suggests the compound can act on biological processes involved in the condition. Friedreich ataxia develops as neurons in the brain and spinal cord deteriorate, progressively affecting movement, speech, and survival. The research found that sulforaphane, a natural compound present in broccoli, can raise levels of frataxin, the protein that is deficient in people with Friedreich ataxia. It also helped protect vulnerable nerve cells from damage. Sulforaphane has also been found to affect several disease-related processes, including cellular stress and inflammation. Intermittent fasting reveals gut-brain pathway that may reduce chronic pain Zhengzhou University & First Affiliated Hospital (China) August 24 2026 (Medical Xpress) Chronic pain, pain that persists or returns for more than three months, can affect people's emotional well-being and is often accompanied by difficulty concentrating or remembering things. Researchers at Zhengzhou University and its First Affiliated Hospital conducted a study investigating the effects of intermittent fasting on chronic pain in mice. Their findings, published in Brain, Behavior, and Immunity, suggest that fasting for set hours can alter gut bacteria and influence the connection between the digestive tract and the brain, which may in turn reduce pain sensitivity and improve mental function. The researchers observed that mice with chronic pain who followed the intermittent fasting regimen appeared to exhibit reduced sensitivity to normally harmless touch and heat. In addition, fasting appeared to improve their performance on simple tasks and reduce anxiety-like behaviors. Collected data suggested that fasting had strengthened the mice's intestinal barrier, reduced neuroinflammation and altered the composition of their gut microbiota. A species of gut bacteria that appeared to consistently increase with intermittent fasting was Alistipes finegoldii. This study suggests that intermittent fasting can change the composition of the gut microbiota, particularly in mouse models of chronic pain. Interestingly, the team also found that supplementing mice with Alistipes finegoldii, the bacterial species that increased with fasting, reproduced the pain-relieving effects and cognitive improvements observed in fasting mice. Microalga extract shows promise for fatigue through mitochondrial function Jeonbuk National University & Yuhan Care Co (South Korea), August 11 2026 (Nutrition) Algae have long been used for nutritional and health-promoting purposes in several cultures. Haematococcus pluvialis, a fresh water green algae widely recognized as containing high levels of astaxanthin, has attracted growing interest as a functional bioresource with potential to improve physical performance and alleviate fatigue; however, its underlying mechanisms remain unclear. This study aimed to evaluate the anti-fatigue effects of H. pluvialis extract (YHC-T-2414) and its underlying mechanisms. Its antioxidant effect was assessed by measuring reactive oxygen species (ROS) generation. Mice were administered YHC-T-2414 for 3 weeks and subjected to an exhaustive swimming test. Subsequently, fatigue-related biochemical parameters, including lactate, LDH, creatine, malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) were measured in serum and muscle tissues. YHC-T-2414 attenuated H2O2-induced reductions in cell viability, and reduced LDH and CK activities and ROS generation in H2O2-treated C2C12 myoblasts. Furthermore, it significantly increased swimming time in the forced swimming mouse model while reducing lactate, LDH, CK, MDA, TNF-α, and IL-6. Vitamin D Supplementation Tied to Slower Biological Aging, Studies Find Yale University, August 23 2026 (Natural News) Recent analyses of clinical trial data have linked daily vitamin D3 supplementation to slower biological aging, according to researchers. A study published in the American Journal of Clinical Nutrition found that 2,000 international units (IU) of vitamin D3 daily significantly reduced telomere shortening over four years among participants. Researchers followed 1,036 adults with vitamin D deficiency in the Berlin Aging Study II and GendAge study for an average of 7.4 years. According to the report, participants who began taking vitamin D supplements after the initial assessment had lower epigenetic age acceleration at follow-up than deficient participants who did not supplement. The difference was about 2.6 years on one epigenetic clock and 1.3 years on another. The report also stated that participants whose deficiency was successfully treated had epigenetic aging measures that were not significantly different from those of vitamin D-sufficient participants. These findings suggest that correcting a vitamin D deficiency may move some markers of biological aging in a more favorable direction.
In this episode of the Phelan-McDermid Syndrome Podcast: Sharing Research, Progress, and Hope, Dr. Lauren talks with Dr. Michael Long of NYU Langone, a neuroscientist studying the brain circuits that make vocal communication possible.This episode is a fascinating look at an unconventional approach to one of the Phelan-McDermid syndrome community's highest research priorities: communication and language.Dr. Long shares how his research has taken him from songbirds and human speech to an unusual animal with remarkable conversational abilities: the singing mouse. Unlike standard laboratory mice, singing mice engage in precisely timed, back-and-forth vocal exchanges, much like humans! After collaborating with Dr. Ben Scott (featured on "A Cross-Species Approach to Advancing Research in Phelan-McDermid Syndrome with Dr. Ben Scott and Amanda Fath"), Dr. Long has been working to develop a SHANK3 knockdown singing mouse. This will allow researchers to better understand the underlying brain circuitry involved in communication and how disruption to SHANK3 alters this.The conversation also explores why communication encompasses much more than spoken words, the importance of including minimally verbal and non-speaking individuals in research, and how "backward translation" (taking observations from individuals with Phelan-McDermid syndrome back into the laboratory) can help scientists ask better questions and develop more meaningful models.If you are interested in being involved with Drs. Scott and Long's study, check out the GEODE (Gathering Evidence for Optimizing Decisions) Study on our Open Studies page or contact: geode.online.experiment@gmail.com.
Blankman is a 1994 movie about two brothers who grow up loving BATMAN '66. We know the feeling. When they grow up, circumstances lead the nerdier brother to style himself as a superhero. It's a comedy — sometimes. The tone of the movie veers too dark in spots to keep it feeling comedic. Is it a terrible movie? Is it a classic? Tim and Paul have watched it and, in the latest Bat Bits, they give their Bat-take on it. Listen to the MP3 for a short clip of the show! Subscribe to our Patreon for $2 a month to hear our discussion of the movie in our bi-weekly examination of Batman 66 on BAT BITS, or, for $4 a month, get that AND our monthly show Silver Age Batman, in which Paul or another in our stable of co-hosts joins Tim to examine individual Batman stories from the 1950s and '60s. In the latest episode, Tim and Paul discuss "The Ice Crimes of Mr Zero" from Batman 121, which was the basis for the Batman 66 episodes "Instant Freeze" and "Mice like Cheese"! Holy treasure trove of Bat info! Sign up today!
NERDSoul.DÉCKOR Geek Wall Art https://www.etsy.com/shop/NERDSoulDeckor Gamepads, Mice, Keyboards, Arcade Sticks, Typewriters, whatever... LFG! Covering: #NERDSoul #MarvelRivals #MarvelTokon . Starring: Blerd-ish: https://www.instagram.com/blerd.ish/ Open Mynd: https://www.instagram.com/blerd.ish/iAmOpenMynd . For: http://patreon.com/ThatNERDSoul | CashApp: $nerdsoul From: https://nerdsoul.myspreadshop.com From: https://nerdsoul.podbean.com
Outer Limits Season 1 Episode 15 The Mice
OPENER: Stephen A Smith DESTROYS WNBA After HIDING BRITTNEY GRINER'S DIRTY SECRET! Defend Sophie Cunningham! - 5:11 Brandon Gill Gets Witness To Admit Who DEI Punishes - 5:13 “I went to court to argue what a woman is” — Sall Grover at ARC 2026 -1:00 Jason Arday Whistleblower: ‘People Knew The Truth And Covered It Up' - 4:00 Quick, easy, worthless: Students let AI do the thinking | Principia Scientific, Intl. - Text It's Time to Save America - 10:00 HEALTH NEWS Arginine Supplement May Strengthen Immune Response to Cancer and Viral Infections Yeast food supplement helps immune cells fight cancer more effectively Physical activity linked to lower stroke and death risk in adults with atrial fibrillation Phthalates may contribute to high blood pressure in pregnant women Daily Collagen Supplement Alters Bone-Related Blood Markers in Female Runners, Study Says Arginine Supplement May Strengthen Immune Response to Cancer and Viral Infections Rockefeller University, August 10, 2026 (Natural News) A study published in the journal Cell reports that arginine, an amino acid found in protein-rich foods and produced by the body, may help the immune system recognize and respond to cancer and viral infections. The research found that low arginine levels were linked to reduced production of MHC-1, a protein that displays abnormal cellular signals to T cells, according to the report. In mouse models, arginine-rich diets were associated with fewer colon tumors and milder influenza and SARS-CoV-2 infections, the researchers reported. The findings add to prior work linking declining immune function to cancer progression. When arginine is scarce, cells struggle to produce MHC-1 proteins, which appear on the surfaces of cells throughout the body and display foreign or abnormal proteins to T cells. Researchers repeated the dietary studies using mouse models of influenza and SARS-CoV-2, conditions previously associated with unusual levels of different amino acids. One of the most dramatic patterns to emerge was that arginine was the most depleted amino acid in all of these diseases. Not only did mice with an arginine-rich diet have milder symptoms from viral infections, giving the mice arginine after influenza infection improved their outcomes too. Yeast food supplement helps immune cells fight cancer more effectively Trinity College Dublin & University College Dublin, July 9 2026 Researchers from Trinity College Dublin (TCD) and University College Dublin (UCD) have shown for the first time that a food supplement made from yeast helps the body to make stronger immune cells that can fight cancer. The research teams found that adding a yeast-based supplement to the food of obese laboratory mice changes how their immune cells grow and help to make better cancer‑fighting cells. Mice were fed a standard or high fat diet supplemented with yeast beta-glucan for 4-12 weeks and then their immune system was challenged by different types of cancer cells (colorectal, skin and breast cancer). The study also tested whether yeast supplementation could overcome immune dysfunction caused by obesity and whether protective effects persist after weight loss. Crucially, this dietary intervention restores anti-tumor innate immunity in obese mice and reverses long-term immune memory defects that persist even after weight loss, a major unmet clinical challenge. Physical activity linked to lower stroke and death risk in adults with atrial fibrillation Arctic University of Norway, August 5 2026 (News-Medical) Being physically active was linked to a lower risk of stroke and death for adults with atrial fibrillation, or AFib, according to new, independent research published in the Journal of the American Heart Association. AFib is a quivering or irregular heartbeat that occurs in the heart's upper chamber known as the atria. According to the American Heart Association, it can lead to blood clots, stroke and other heart-related conditions. The prevalence of AFib in the U.S. was estimated at 4.48% of the adult U.S. population. The study tracked more than 87,000 adults in Norway for about 15 years, capturing information about AFib, stroke and death from national health registries. What did the analysis find? Compared to adults who were inactive, adults with a low, moderate or high level of physical activity had a 9%, 19% and 18% lower risk of stroke, respectively. Having a low, moderate or high level of physical activity was associated with an 11%, 18% and 22% lower risk of death from any cause, respectively. For people with AFib, staying active was tied to living an average of 0.5 to 1.2 years longer compared to those who were inactive Phthalates may contribute to high blood pressure in pregnant women Harvard School of Public Health, August 10 2026 (News-Medical) Phthalates, which are chemicals found in plastics, personal care products and hundreds of other consumer goods, may contribute to high blood pressure in pregnant women, according to a study published in the Journal of the Endocrine Society. The researchers measured phthalate exposure and blood pressure in 338 pregnant women at three points during pregnancy. They analyzed whether higher levels of these chemicals-individually and in combination-were linked to higher blood pressure or an increased risk of pregnancy-related high blood pressure disorders. The authors found that pregnant women with higher urine concentrations of fragrance-associated phthalates and those in personal care products had higher systolic and diastolic blood pressure markers of an increased risk of hypertensive disorders of pregnancy. About 13% of participants in the study developed a pregnancy-related high blood pressure disorder. Women with higher levels of certain phthalates, especially those found in personal care products, tended to have higher blood pressure later in pregnancy. Daily Collagen Supplement Alters Bone-Related Blood Markers in Female Runners, Study Says Fitchburg State University, University of Connecticut & Mayo Clinic, August 4 2026 (Natural News) A four-week randomized, double-blind, placebo-controlled trial found that female distance runners who took 20 grams of collagen peptides per day showed an approximately 5.1 percent rise in P1NP over four weeks, a blood marker of bone formation, while the placebo group showed no such change, according to a study published in Frontiers in Nutrition. The collagen group also showed a drop in IL-6, an inflammatory protein linked to bone breakdown, while placebo levels held steady or rose, the study reported. The trial included 22 female runners ages 18 to 35 who ran at least 35 miles per week, and no adverse effects were reported. Collagen is the most common and abundant protein in the body, accounting for about 30 percent of total protein content and providing structural support to bones, tendons, ligaments, and other connective tissues, according to published research. Discussion about this episode
A #Research paper recently #Published in Volume 18 of Aging, titled “Slowing intervertebral disc aging in mice through long-term systemic treatment with the senolytic BCL-2/BCL-xL proteolysis targeting chimera (PROTAC) 753b,” examines whether the senolytic PROTAC 753b can slow age-related intervertebral disc degeneration (IDD) in mice. Long-term systemic treatment with 753b reduced key features of disc degeneration in 22-month-old male mice, including matrix breakdown, loss of disc aggrecan, age-related structural changes, and inflammatory markers such as IL-6 and TNFα. These benefits, however, were not observed in female mice, highlighting potential sex-based differences in the role of cellular senescence in IDD and the response to senolytic therapies. DOI - https://doi.org/10.18632/aging.206394 Corresponding author - Nam Viet Vo - nvv1@pitt.edu Abstract video - https://www.youtube.com/watch?v=t0z4MULDr1A Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206394 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, intervertebral disc aging, cellular senescence, senolytic, anti-apoptosis, PROTAC-753b To learn more about the journal, please visit https://www.Aging-US.com and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
Researchers at the University of Montana identified a unique mouse that may hold some clues for cancer research. This Andean mouse's high-elevation home is what attracted researchers.
Financial counselling available for poultry and egg producers to prepare for bird flu impacts, nice numbers reduce across SA as farmers take advantage of stronger baits, and farm buildings included in expanded government program to slash cost of installing rooftop solar.
In Dumb Ass News, a woman admitted to the internet that she sipped her day-old drink in the car, only to later find a dead mouse in there. The Tribe called in with their mouse encounters, spoiled food moments, or other unpleasant surprises. Photo credit: Reuters
BUFFALO, NY — August 3, 2026 — A new #research paper was #published in Volume 18 of Aging on July 17, 2026, titled “Selective targeting of cancer and senescence via shared metabolic shifts extends lifespan of old mice.” The study was led by first author Zachery R. Robinson, and corresponding author and Aging editorial board member Irina M. Conboy, both from the Department of Bioengineering and QB3 Institute, University of California, Berkeley. The researchers developed a new combination therapy that selectively targets both cancer cells and senescent cells by exploiting metabolic vulnerabilities shared by these two cell types. In laboratory studies and aged mice, the treatment selectively eliminated senescent cells and reduced cancer cell viability while improving physical performance and extending lifespan without significant toxicity to healthy tissues. Cancer and aging are closely linked. As people age, senescent cells accumulate throughout the body. Although these cells no longer divide, they remain metabolically active and release inflammatory molecules known as the senescence-associated secretory phenotype (SASP), which contributes to chronic inflammation, tissue dysfunction, and tumor progression. Existing therapies such as the BCL-2/BCL-xL inhibitor navitoclax (ABT-263) can eliminate both cancer cells and senescent cells but require doses that frequently cause thrombocytopenia, a potentially serious reduction in platelet counts that has limited their clinical use. Full press release - https://www.aging-us.com/news-room/new-drug-combination-targets-cancer-and-senescent-cells-while-extending-lifespan-in-old-mice DOI - https://doi.org/10.18632/aging.206399 Corresponding author - Irina M. Conboy - irina@generationlab.co Abstract video - https://www.youtube.com/watch?v=7p5JMvy9Twg Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206399 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, senescence, cancer, metabolic shift, ATP To learn more about the journal, please visit https://www.Aging-US.com and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
Our friend Steve Lin joins Will this week for a broad discussion about hobbies, learning new skills, and preserving the past. Topics include everything from the multidisciplinary practice of maintaining arcade cabinets and pinball tables, the Video Game History Foundation's new archive of E3 materials, watch repair, model trains, preserving the institutional knowledge of diehard hobbyist communities, how to get started picking up new skills and knowing when to call it quits on a project, and plenty more. The VGHF's E3 materials archive: https://gamehistory.org/e3-history/ Support the Pod! Contribute to the Tech Pod Patreon and get access to our booming Discord, a monthly bonus episode, your name in the credits, and other great benefits! You can support the show at: https://patreon.com/techpod
Dan, James, Anna and Andy discuss stress, sentences and supermarkets. Visit nosuchthingasafish.com for news about live shows, merchandise and more episodes. Join Club Fish for ad-free episodes and exclusive bonus content at apple.co/nosuchthingasafish or nosuchthingasafish.com/patreonEdited by James HarkinProduced by Leying LeeTeam includes Tara Dorrell, Joe Mayo and Ethan Ruparelia
On the latest Bat Bits, we finish our look at the draft of "The Ring of Wax" by Jack Paritz and Bob Rodgers, featuring a nonexistent fountain, a gun that doesn't make it to the final, the return of a familiar building, and more! Subscribe to our Patreon for $2 a month to see the script and hear our discussion of it in our bi-weekly examination of Batman 66 on BAT BITS, or, for $4 a month, get that AND our monthly discussion of Silver Age Batman comics, as Paul or another in our stable of co-hosts joins Tim to examine individual Batman stories from the 1950s and '60s. In the latest episode, Tim and Paul discuss "The Ice Crimes of Mr Zero" from Batman 121, which was the basis for the Batman 66 episodes "Instant Freeze" and "Mice like Cheese"! Holy treasure trove of Bat info! Sign up today!
NERDSoul.DÉCKOR Geek Wall Art https://www.etsy.com/shop/NERDSoulDeckor Gamepads, Mice, Keyboards, Arcade Sticks, Typewriters, whatever... LFG! Covering: #NERDSoul #MarvelTokonFightingSouls #MarvelTokon Starring: Open Mynd: https://www.youtube.com/@OpenMynd82 Blerd-ish: https://www.instagram.com/blerd.ish/ . For: http://patreon.com/ThatNERDSoul | CashApp: $nerdsoul From: https://nerdsoul.myspreadshop.com From: https://nerdsoul.podbean.com
BUFFALO, NY — July 27, 2026 — A new #research paper was #published in Volume 18 of Aging on July 13, 2026, titled “Slowing intervertebral disc aging in mice through long-term systemic treatment with the senolytic BCL-2/BCL-xL proteolysis targeting chimera (PROTAC) 753b.” The study was led by first author Peter G. Alexander from the Ferguson Laboratory for Spine Research, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, and corresponding author Nam Viet Vo from the same institution. Intervertebral disc degeneration is a leading cause of chronic low back pain and disability. As discs age, they lose important structural components, become less able to absorb mechanical stress, and accumulate senescent cells—dysfunctional cells that stop dividing but continue releasing inflammatory molecules that contribute to tissue degeneration. Senolytic therapies, which selectively eliminate these cells, have emerged as a promising strategy to slow age-related diseases. In this study, researchers evaluated PROTAC 753b, a next-generation senolytic designed to target the anti-apoptotic proteins BCL-2 and BCL-xL while reducing the platelet toxicity associated with earlier drugs in this class. The researchers treated 16-month-old male and female mice with PROTAC 753b for six months and evaluated their intervertebral discs at 22 months of age using histology, molecular analyses, and measurements of inflammatory markers. The treatment significantly improved several measures of intervertebral disc health in aged male mice, preserving the extracellular matrix protein aggrecan and reducing matrix metalloproteinase (MMP)-mediated aggrecan breakdown, a hallmark of disc degeneration. In contrast, female mice showed little overall improvement, revealing a sex-specific response to treatment. Full press release - https://www.aging-us.com/news-room/senolytic-protac-slows-age-related-intervertebral-disc-degeneration-in-male-mice DOI - https://doi.org/10.18632/aging.206394 Corresponding author - Nam Viet Vo - nvv1@pitt.edu Abstract video - https://www.youtube.com/watch?v=t0z4MULDr1A Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206394 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, intervertebral disc aging, cellular senescence, senolytic, anti-apoptosis, PROTAC-753b To learn more about the journal, please visit https://www.Aging-US.com and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
Batman-On-Film.com is celebrating the 60th Anniversary of Season 1 of the 1960s BATMAN TV series with our Batteries to Power podcast series on The Original BOF Podcast! On the 6th installment, BOF Senior Contributors Javi Trujillo and Trey Jackson discuss the episodes "A Riddle a Day Keeps The Riddler Away/When the Rat's Away the Mice Will Play".
Erik Marino details his brutal vertigo battle (inner ear crystals spinning him out, Epley maneuver gone wrong, and possible mouse-related Hanta fears), while Ron the Waiter gets grilled for his suddenly darker “beach hair” that definitely isn't dye. The guys spiral into Blue Steel impressions, movie quote wars, Monica turning 53, and a fortune cookie that swears December will be chill. Pure unfiltered chaos.Thanks for dontaing to the show https://www.paypal.com/ncp/payment/JANCGHFW7GJHA helps me to keep this going. Peace!
Dr. Nilesh Ambhore interviews Dr. Gerard H. Koppelman about his article, "Protocadherin-1 Deficiency Increases Baseline and Allergen-Induced Airway Hyperresponsiveness in Mice."
Mackenzie Pflum joins Nick Wilson and Jonathan Peterlin to describe a persistent mouse infestation at her Cleveland apartment and her frustration with management's refusal to let her out of her lease early. They also touch on Stephen Vogt's comments regarding the Cleveland Guardians and prepare for John Fanta's upcoming guest appearance. 01:02 - John Fanta Power Move 02:19 - Guardians News With Vogt 04:28 - Mackenzie Pflum Mouse Infestation
Hello everyone!Robin was in Joseph and his Amazing Technicolour Dream Coat and Juno went to watch it with Mummy and Daddy, and we have an interview with Mrs Mice-alot.Plus Ask the 8 Ball, Farty Facts, Juno's Book Review, True Story, Mice News and Joke of the Week.We love you all!Email: robinandjuno@gmail.com
On today's pages, Chullin 78 and 79, the Talmud invites us to think more deeply about the animals with whom we share the world. Recorded around a barbecue table in upstate New York, this special summer episode with Rabbi Dovid Bashevkin and producer Josh Kross explores why Judaism teaches both profound compassion for animals and a profound appreciation for what makes human beings different. How do we honor both without diminishing either? Listen and find out.
On the latest Bat Bits, we continue walking through the draft of "The Ring of Wax"/"Give 'Em the Axe" by Jack Paritz and Bob Rodgers, featuring the final mention of the Batmobile's security system, a significant change following the deathtrap, a swap of one antifeminist comment for another, and more! Subscribe to our Patreon for $2 a month to see the script and hear our discussion of it in our bi-weekly examination of Batman 66 on BAT BITS, or, for $4 a month, get that AND our monthly discussion of silver age Batman comics, as Paul or another in our stable of co-hosts joins Tim to examine individual Batman stories from the 1950s and '60s. In the upcoming episode of Silver Age Batman to be published on Patreon July 25, Tim and Paul discuss "The Ice Crimes of Mr Zero" from Batman 121, which was the basis for the Batman 66 episodes "Instant Freeze" and "Mice like Cheese"! Holy treasure trove of Bat info! Sign up today!
What started as a simple garage cleanup turned into one of the most unexpected wildlife rescues we’ve ever experienced! While getting organized for an upcoming yard sale, Leah discovered a mother mouse and five tiny babies hiding in a box. We share the surprisingly heartwarming story of how Mom made her escape, how we safely […] The post We Rescued Baby Mice… Then Everything Went Wrong appeared first on The ESO Network.
Group Leader in the Cancer Immunology Program at the Peter MacCallum Cancer Professor Paul Beavis joined Ross Stevenson and Russel Howcroft to discuss how this testing could impact cancer in humans.See omnystudio.com/listener for privacy information.
Broadcast from KSQD, Santa Cruz on 7-09-2026: Researchers refined a technique to reverse skin cell aging by about 30 years while preserving cellular identity. Exposing adult fibroblasts to Yamanaka factors—stopping before full reversion to pluripotent stem cells,reset the epigenetic clock and gene expression patterns to resemble much younger cells. The rejuvenated fibroblasts produced significantly more collagen, migrated faster to close artificial wounds, and showed reversal of gene expression patterns associated with Alzheimer's and cataracts. Since long-term epidemiologic data doesn't yet exist, Dr. Dawn follows up on last week's vaping question by exploring cancer mechanisms. Vaping aerosols impair DNA repair fidelity while triggering IL-6, IL-8, and TNF-alpha secretion. Nicotine-derived nitrosamines, reactive carbonyls (formaldehyde, acetaldehyde, acrolein) are generated when propylene glycol and vegetable glycerin are heated. Upregulated cytochrome P450 enzymes convert precarcinogens like benzopyrene into carcinogens. Mice exposed for 54 weeks developed lung adenocarcinomas in 22% and precancerous bladder hyperplasia in 57%, with markers matching those show predict lung cancer years before diagnosis. The Mexican Biobank—which includes over 40,000 samples from all 31 Mexican states revealed dramatic regional variation in drug-metabolism genes driven by Indigenous ancestry. In Chiapas, nearly 40% of the population carries two copies of a CYP2D6 variant reducing fentanyl metabolism, versus just 10% in Sinaloa. The SLCO1B1 variant hindering statin metabolism is found in over 15% of Yucatán residents., where 8 million Mexicans take statins. Dr. Dawn discusses both the promise and potential dark side of population genetic testing, including UK plans to genotype all children at birth for inborn errors of metabolism. Dr. Dawn briefly revisits the recent Indian study showing conch-shell blowing reduces sleep apnea by 34%, comparing it to earlier didgeridoo research, both of which strengthen airway muscles through forced-blowing exercises. A caller from Capitola recovering from non-Hodgkin's lymphoma near the L5 nerve asks about Japanese Kampo medicine formulas (Goshajinkigan, Yokukansan) for post-treatment nerve pain. Dr. Dawn suggests the pain likely originates from scar tissue tethering the nerve, and recommends consulting the Oriental Medicine Doctor program at Five Branches in Santa Cruz where faculty can advise on herbal formulas that trace back thousands of years through cultural exchange between China and Japan. Dr. Dawn explains Lp(a):lipoprotein(a), a small protein string attached to LDL particles that promotes clumping and clotting, is a genetically-determined coronary artery disease and stroke risk factor invisible to standard lipid panels. Levels of 250 particles double coronary risk and 350 particles triple it. Less than 75 is normal. Two new pharmaceutical strategies are in development to reduce Lp(a) : antisense oligonucleotides (single-stranded RNA that recruits RNase H to cleave target mRNA) and small interfering RNA (double-stranded RNA that triggers destruction of matching mRNA). Pelacarsen, a monthly injection in Phase 3 trials, reduces Lp(a) by 80%. These gene-silencing platforms open therapeutic possibilities for previously undruggable orphan diseases. Vitamin K2 is produced in the gut microbiome. MK-4 is most common in humans. Dr. Dawn recommends MK7 for stabilizing coronary calcium plaques and directing calcium into bone. A study of hepatitis B and C patients found MK4 to be protective in hepatocellular carcinoma. HCC developed in 2 of 21 MK-4-treated patients versus 9 of 19 controls, with a risk ratio of 0.2. MK-4 activates protein kinase A in vitro, inhibits HCC invasiveness, and restores apoptosis signaling that cancer cells normally block. Dr. Dawn recommends a couple milligrams of MK-4 daily for anyone with cirrhosis or prior hepatitis B or C infection.
The Mothers Of Invention- Paralipomeni Della Batracomiomachia Paris- 1970The December 1970 Paris gig was a standout date during their European tour. The setlist included iconic Zappa tracks and heavy improvisations like "Dog Breath," "A Pound for a Brown on the Bus," and "Call Any Vegetable". The band featured an incredible lineup that included:Frank Zappa (Guitar/Vocals)Mark Volman & Howard Kaylan (better known as Flo & Eddie)Ian Underwood (Keyboards/Woodwinds)Jeff Simmons (Bass)Aynsley Dunbar (Drums)Frank Zappa and The Mothers of Invention performed this legendary concert at the Gaumont-Palace in Paris, France on December 15, 1970. The show famously featured renowned French jazz violinist Jean-Luc PontyBatracomiomachia: Translates from Ancient Greek as the "Battle of the Frogs and Mice" (a classical comic epic parodying the Iliad).Paralipomeni: An Italian term for an appendix, sequel, or "things left out". The Italian poet Giacomo Leopardi wrote a famous satirical continuation titled Paralipomeni della Batracomiomachia in 1831.1 | | Penis Dimention | 11:262 | | The Air | 3:533 | | The Dog Breath / Mother People | 4:234 | | You Didn't Try To Call Me | 3:345 | | King Kong | 32:416 | | Who Are The Brain Police? | 6:32
A study in mice funded by the NIEHS Superfund Research Program (SRP) reported that juvenile mice may be more susceptible to the damaging effects of N-nitrosodimethylamine (NDMA) exposure than adult mice. Experiments that artificially increased cell growth and division also show that susceptibility may be driven by cell division during exposure.
Chris Svec returns to the show to discuss the messy, non-linear realities of engineering management and onboarding new college graduates. We explore why companies should bother hiring fresh grads in the first place, how to prevent junior developers from going dark when they get stuck, and why admitting ignorance publicly is an absolute workplace superpower. Along the way, we dive into managing genius firmware engineering hires, battling technical debt and software entropy, and why your development team shouldn't communicate solely through pull request comments. Chris Svec is the Director of Embedded Software Engineering at Insulet. If you're looking for an experienced leadership or management thought partner to help scale your development team, Chris Svec offers private coaching and consulting. You can reach him directly at the email given in the show (or hit the contact link and we'll forward your message along). RECOMMENDED BOOKS FOR ENGINEERING MANAGERS & TECH LEADS The Manager's Path by Camille Fournier – A guide for navigating tech leadership and managing engineering teams. Resilient Management by Lara Hogan – A book dedicated to the human side of engineering management. SOFTWARE ARCHITECTURE & EMBEDDED SYSTEMS RESOURCES A Philosophy of Software Design by John Ousterhout – A high-level philosophical perspective on software engineering and architecture. The Pragmatic Programmer by Andrew Hunt and David Thomas – A classic text on software development best practices. Joel on Software by Joel Spolsky – Insights on software development methodologies and managing tech teams. Making Embedded Systems by Elecia White – A comprehensive guide to firmware design patterns and embedded architecture. Embedded for Everyone by Nathan Jones – A curated repository of accessible embedded system learning resources. EDUCATIONAL PROGRAMMING GAMES Shenzhen I.O. by Zachtronics – An interactive puzzle game for learning assembly programming. Typer Shark! Deluxe – A classic game to improve typing speed and precision for developers. MENTIONS AND EPISODE CONTEXT Embedded.fm blog post: Resilience is a Skill and Embedded Skills Tree The "Meow Meow Beans" episode from the TV show Community (season 5, episode 8), see a snippet. All Systems Red by Martha Wells – The sci-fi novel featured in today's closing quote If you want to dive into Svec's previous appearances on the podcast, be sure to check out: 78: Happy Cows (His very first appearance, discussing empathy in software development) 250: Yolo Snarf (All about version control, gitflow, and D&D) 297: Mice to Do My Bidding (Focusing on attentional focus and workflow psychological tricks) 402: We Are a Lazy Species (Software schedule estimation alongside Philip Johnston) 436: 20 GOTO 10 (Discussing modern kids' programming languages and the longevity of the Joel Test) Transcript
Whether you knew her for "Total Eclipse of the Heart" or "I Need a Hero" (which was made famous in the Utah-made movie "Footloose"), Bonnie Tyler was a major part of the 80s music scene. Overnight, she passed away at the age of 75. Greg and Holly reminisce about her before turning to a new discovery from scientists: elephants aren't actually scared of mice. Wait what?
NERDSoul.DÉCKOR Geek Wall Art https://www.etsy.com/shop/NERDSoulDeckor Gamepads, Mice, Keyboards, Arcade Sticks, Typewriters, whatever... LFG! Covering: #NERDSoul #AvatarLegends #Playstation . Starring: Blerdish: https://linktr.ee/blerd.ish Open Mynd: https://bsky.app/profile/openmynd.bsky.social TJ Storm: PSN - TJStorm . For: http://patreon.com/ThatNERDSoul | CashApp: $nerdsoul From: https://nerdsoul.myspreadshop.com From: https://nerdsoul.podbean.com
Send us Fan MailWhat if the to peace isn't about controlling your life, but changing your relationship with reality?In this episode, we explore one of the most challenging ideas in Stoicism through a single line from Epictetus:"Demand not that events should happen as you wish; but wish them to happen as they do happen, and you will go on well."At first glance, it sounds like surrender. Lower your expectations. Stop caring. Accept mediocrity.But that's not what the Stoics meant.We'll explore the difference between giving up and giving your full effort without demanding a particular outcome. Along the way, we'll examine the psychology of control, the Stoic idea of "co-fated" events, and why your actions still matter—even if the future is ultimately outside your control.We'll also discuss:Why suffering often comes from resisting reality.The difference between acceptance and passivity.Locus of control, the illusion of control, and self-fulfilling prophecies.Marcus Aurelius on why labeling outcomes as "good" or "bad" leads to resentment.Practical examples from sports, everyday life, and my own experiences.The central idea is simple:Act as though everything depends on your effort. Accept that the outcome never did.When you stop demanding reality be different, you don't become passive—you become free.
Send us Fan MailJumping into the time machine today, back to 1968 when a researcher built a paradise for mice. A place with unlimited food, total safety, nothing to fear, and watched the whole thing fall apart anyway.Support the showJoin the Patreon community https://www.patreon.com/richardnichollsSocial Media LinksBluesky https://bsky.app/profile/richardnicholls.netThreads https://www.threads.net/@richardnichollsrealInstagram https://www.instagram.com/richardnichollsrealFacebook https://www.facebook.com/RichardNichollsAuthorYoutube https://www.youtube.com/richardnichollsTikTok https://www.tiktok.com/@richardnichollsauthorX https://x.com/richardnicholls
NERDSoul.DÉCKOR Geek Wall Art https://www.etsy.com/shop/NERDSoulDeckor Gamepads, Mice, Keyboards, Arcade Sticks, Typewriters, whatever... LFG! . Covering: #NERDSoul #MarvelTokon #GTA6 . Starring: Blerdish: https://linktr.ee/blerd.ish Open Mynd: https://bsky.app/profile/openmynd.bsky.social TJ Storm: PSN - TJStorm . For: http://patreon.com/ThatNERDSoul | CashApp: $nerdsoul From: https://nerdsoul.myspreadshop.com From: https://nerdsoul.podbean.com
Full show notes: https://bengreenfieldlife.com/mitrix In this episode with Tom Benson, founder and CEO of Mitrix, you'll hear why mitochondrial decline may be the actual root cause of aging rather than just a downstream symptom of it, and why most of the drugs developed so far to address it don't touch the real problem: damaged mitochondrial DNA. We discuss how Tom's company grows new, healthy mitochondria inside a bioreactor using banked stem cells, what mitochondrial transplantation actually looks like in real human cases already happening today, and the mouse study that gives this episode its name, in which severely aged mice receiving repeated mitochondrial injections were, according to the technicians running the experiment, climbing the walls of their cages by the very next day. Tom also touches on his original theory on the mitochondrial cycle of the body, how mitlets differ from naked mitochondria, and what his own MitoClock test reveals using nothing more than a urine sample. Tom Benson is the CEO and founder of Mitrix. He is a serial entrepreneur and scientist who has founded four successful software, hardware, and science startups. He has published dozens of articles and video lectures on mitochondrial science and cellular energetics, and developed original theories on the systemic transfer and distribution of mitochondria within higher organisms and how that affects health and lifespan. Episode Sponsors: Troov: An all-natural energy powder combining green tea caffeine, L-theanine, beetroot, amino acids, adaptogens, and electrolytes for steady energy and focus without the crash. Visit DrinkTroov.com/BEN and use code BEN for 30% off your first order, plus free shipping and a 30-day money-back guarantee. Our Place: Upgrade to a kitchen free of forever chemicals. Go to fromourplace.com/ben and use code BEN for 10% off sitewide. BON CHARGE: A holistic wellness brand with products that address sleep, performance, recovery, hormone balance, and inflammation. Go to boncharge.com/GREENFIELD and use code GREENFIELD to save 15%. Tecton Ketones: Bioidentical D-beta-hydroxybutyrate (BHB) for clean cognitive support, stable energy, and performance without the conversion step required by many ketone precursors. Visit tectonketones.com/ben and use code BEN for 16% off your first order. LYMA Laser: An advanced at-home skin technology backed by peer-reviewed research showing it influenced 45 genes in human skin compared to just one for an equivalent LED device. Visit lyma.life and use code BEN10 for 10% off for a limited time.See omnystudio.com/listener for privacy information.
Bob Zimmerman reports research showing weightlessness harms reproduction in mice, suggesting humans will need artificial gravity for long-term missions. On Mars, Curiosity discovered unique polygon ridges, possibly indicating ancient water. Additionally, New Horizons confirmed the solar wind slows at the solar system's edge. (8)IDAHO
In this week's episode, Blood editor Dr. James Griffin interviews Drs. Heinz Zoller and Raul Ribeiro on their latest articles published in Blood. Dr. Zoller discusses "Ferric Carboxymaltose Increases Fracture Risk in Patients and Reduces Bone Formation in Mice with Iron Deficiency Anemia", and how these findings support consideration of alternative IV iron formulations that provide similar efficacy without risk of skeletal complications. Dr. Ribeiro discusses "A low-versus standard-dose regimen an induction for AML: a multicenter, randomized noninferiority trial" and how the low-dose regimen is associated with fewer toxicities, faster hematologic recovery, and reduced health care costs, suggesting a feasible treatment strategy for resource-limited settings.
The Steam Machine has finally been released, and if it wasn't for the price of RAM it would probably sound a lot better. But make sure you save some money for GTA6 because ouch.Scientists have discovered a cluster of neurons in mice that cause them to have ADHD. It could lead to a permanent treatment for ADHD, which is pretty exciting.Critics think Anime is becoming commoditized. What does that even mean? Who cares?***We enjoyed a nice drink of Rez which you can get a 10% discount when you type NERDS at the checkout from the Rez website at www.drinkrez.com ***Resources MentionedAll the news from the Steam Machine and GTA 6 ("This is going to be a niche device" – Analysts react to the $1,000+ Steam Machine price reveal | GamesIndustry.biz, GTA 6 - all you need to know about Rockstar's blockbuster game, Rockstar Games Responds to GTA 6 Physical Disc Backlash)ADHD Mice (Scientists discover ancient brain cells that help block distractions | ScienceDaily, Evolutionarily old brainstem neurons are required for the control of selective spatial attention | Nature Communications )Anime as a commodity (Anime's growing commoditization could lead to a future where the medium itself no longer matters, Japanese critic warns - AUTOMATON WEST)Full Show Notes : https://docs.google.com/document/d/1KoEtH9hnCRRr48QCYGDmIE_tIeKrLoK3oWGw9ZcAWMw/edit?usp=sharing***If you'd like to be featured on the show, send us an email: Nerds.Amalgamated@gmail.comFollow us on: Facebook || Twitter || TwitchJoin the Community on Discord: https://discord.gg/cb9G4sVCPkAnd watch us on YouTube: Nerds Amalgamated - YouTube
Its a fun one this week as we bring in an honorary amigo Kieran Squires (The Drycleaner) to talk about a raft of fun comic topics. From a big comic mart discussion, to underused heroes that deserve a spotlight to those popular creators that we just don't get, its an absolutely jam packed comics chat that guaranteed to get you jumping online to read comics or just let us know what you think! Great stuff to check out: Kieran Squires, London Comic Mart, Kellys Comic Fair, Mega City Book Club, Inkblot Festival, Three Planes, Roger Mason, The Mice, Commando, The Cannibals, Field Mouse Press, Noir City Murders, Green Archer Comics, The Saint, Rebellion, ABC Warriors, Rising Stars, J Michael Straszinski, Rising Stars: Visitations, Vanguard, Dan Butcher, XMen: Elsewhen, Periodical, Durin, Rachael Ball
On this episode we have on David Reminick from Paper Mice and his new kids band DadJoke.We talked about food, loving to cook, some of our favorite things to cook or eat, therapy, ADHD, learning to prioritize yourself, trying new things and challenging yourself, being nicer to yourself, what life lessons you teach your kids, what you unlearn when you become a parent, his time in Paper Mice and his experience make music for kids as DadJoke, and realizing you've added way too many layers to a kids song.Make sure to go to dadjokemusic.com to find the music! DadJoke is weird music for weird kids and extremely creative, silly, and fun.Send us Fan MailFollow us on Facebook and Instagram and TikTok YouTube. Look for new episodes of The Imperfect Dads Podcast every Monday and Thursday.This podcast is part of the Never A Phase Network, follow them on instagram at @neveraphasenetwork and check out their podcasts like Emo Kids Anonymous Wasting Time Podcast Certified Fangirl and The Ska Mailman
Broadcast from KSQD, Santa Cruz on 6-25-2026: Dr. Dawn devotes the show's opening to ivermectin for COVID. She walks through critical thinking principles—considering the source, cross-verification, and recognizing self-interested claims—before reviewing the evidence. The most-cited 2021 Bulgarian study of 300 people showing 77% reduction lacked accessible methods, and larger trials capable of detecting even small benefits failed to confirm efficacy. On safety, the standard 12mg parasitic dose every few weeks is well-tolerated due to the blood-brain barrier and efflux pumps that keep ivermectin out of the brain, but daily long-term dosing has caused encephalopathy, liver and kidney damage, and birth defects. Critical drug interactions—macrolide antibiotics, verapamil, proton pump inhibitors, and beta blockers—disable the efflux mechanism, and high-fat meals increase absorption 2.5-fold. Dr. Dawn shares two inflammation formulas calculable from any CBC. The Systemic Inflammatory Index (neutrophils × platelets ÷ lymphocytes) flags runaway inflammation: 200-500 is good, above 900 warrants investigation and correlates with worse stroke outcomes and rising tumor burden. The SIRI (neutrophils x monocytes ÷ lymphocytes) detects chronic tissue inflammation and early innate immune activation: below 500 is good, above 1500 indicates trouble and correlates with cardiovascular mortality and arterial plaque from M1 macrophage activity. Dr. Dawn shares two takeaways from the Institute for Functional Medicine annual conference: in patients at high cardiovascular risk by cholesterol, each gram daily of combined EPA/DHA produces a 9% risk reduction, with bruising as the dose-limit signal. Additionally, a 15-minute walk within 30 minutes of a meal nearly eliminates postprandial inflammation. An emailer asks whether an endocrinologist's claim that vitamin D leaches calcium from bones is true. Dr. Dawn confirms that very high vitamin D (above 150 nanograms, with concern starting above 90) elevates 1,25-vitamin D, which stimulates osteoclast formation and increases C-telopeptide markers of bone breakdown. A crowdsourced question asks how histamines work in women. Dr. Dawn explains histamine functions as a CNS neurotransmitter promoting alertness, wakefulness, and pain perception (deficient in narcolepsy), and as a GI signal driving acid secretion, motility, and visceral sensation. Gut bacteria can convert histidine to histamine, and fish left to spoil can trigger anaphylactic-like reactions from accumulated bacterial histamine. She notes stomach acid treatments Tagamet and Zantac are H2 blockers rather than the more familiar H1 antihistamines, and confirms histamine correlates with hormones but not particularly with minerals. A crowdsourced question on B vitamins for women in their mid-twenties prompts Dr. Dawn to recommend prenatal vitamins for those who might become pregnant, and B100 complex with calcium taken with a little apple cider vinegar for those on restricted diets or eating mostly fast food. Another question asks about chest versus belly breathing. Dr. Dawn explains babies demonstrate proper diaphragmatic breathing (belly protrudes on inhalation) while accessory muscle use signals fight-or-flight—or pneumonia in a non-crying infant. Chest breathing raises adrenaline; belly breathing calms it in adults. How do I stop compulsive scratching? Dr. Dawn explains neurodermatitis has its own ICD-10 code alongside compulsive nail-biting and hair-pulling, and it is diagnosed by sparing of unreachable areas like the mid-back between shoulder blades. Treatment includes nail clipping, lubricants, covering scabbed areas, and Prozac—which uniquely among antidepressants has a secondary indication for neurodermatitis. Zurich researchers combined immature human nerve cells with magnetic nanoparticles to create 6-micrometer NPC bots that can be magnetically positioned at spinal cord injury sites and then triggered by pulsatile magnetic stimulation to mature into nerve tissue. Mice with severed spinal cords regained movement and brain-muscle electrical signals by day 34 after daily 30-minute treatments. A study of 15,000 people with myalgic encephalomyelitis/chronic fatigue syndrome identified eight genetic regions distinguishing them from controls. Two relate to immune response to infection—consistent with the post-infectious onset many sufferers describe, including roughly half of long COVID patients—and others link to the nervous system and chronic pain. Dr. Dawn frames ME-CFS as an immune system stuck in the "on" position, unable to brake against an enemy that is long gone. An emailer asks about prostate biopsy approaches. Dr. Dawn explains the new transperineal biopsy (through skin between scrotum and anus) reduces post-biopsy infection from 1.5% to near zero and eliminates prophylactic antibiotics, though it requires more anesthesia and time. Cancer detection rates match the transrectal approach when both use MRI targeting, and she expects the transperineal approach to become standard.
In this episode of Reading With Your Kids, we're celebrating humor, heart, and the power of picture books to bring families together. Most of our time is spent with Ann Koffsky, author of Blazing Humor: Mel Brooks Is Seriously Funny. Ann and Jed dive into why Mel Brooks' comedy, while very much for adults, still offers a powerful, kid-friendly life story. Ann talks about the challenge of sharing a famously edgy comedian with young readers—focusing not on the racy jokes, but on Mel's resilience, his use of humor to face bullies, racism, and hard times, and his joyful Jewish identity. She describes curating a YouTube playlist of kid-appropriate Mel Brooks clips and reflects on how picture books might be one of the last truly shared media experiences for grown-ups and kids. Together, they explore how humor can be a survival skill in an angry, algorithm-driven world. Next, Evelina Ruimy joins the show to introduce The Kind Bunny, the first in her Hops Tales series. Written during a frightening wildfire evacuation, the book helps families talk about unkind words, hurt feelings, and why kindness begins with how we treat ourselves. Evelina shares how Bunny chooses to answer rudeness with kindness, turning conflict into friendship, and how parents can use the story to start meaningful conversations about bullying and self-worth. Finally, Bob Richley stops by to chat about Redeeming Rhubarb, a middle-grade novel about a mouse, a rat, and what it really means to love your enemies—even when you've been taught to hate them.
Fish Oil Supplements And Alzheimer's-Related Decline A two-year randomized, double-blind, placebo-controlled trial led by researchers at USC tested whether 2,000 mg of DHA fish oil daily could slow Alzheimer's-related brain changes in 365 adults ages 55–80 who rarely consumed fish and had at least one Alzheimer's risk factor. Researchers confirmed the supplement reached the brain by measuring a roughly 17% increase in cerebrospinal fluid DHA after six months. Despite successfully increasing brain DHA levels, participants taking fish oil showed no significant improvements in memory, global cognitive function, or hippocampal volume compared to placebo after two years. Host Dave Asprey explains why raising a single biomarker doesn't always translate into better brain performance, why nutrition works differently inside a complete dietary pattern than as an isolated supplement, and what this study means for anyone relying on fish oil as an Alzheimer's prevention strategy. Sources: https://medicalxpress.com/news/2026-06-fish-oil-supplements-alzheimer-decline.pdf https://www.cnn.com/2026/06/18/health/omega-3-fish-oil-algae-supplement-wellness ~~ DASH Diet Showed the Strongest Link to Long-Term Brain Health Researchers from Harvard analyzed dietary data from 159,347 participants across three long-running U.S. health studies to examine how eating patterns influence cognitive aging. Participants completed dietary questionnaires every four years over several decades, allowing investigators to compare six healthy dietary patterns, including the DASH and Mediterranean diets. While all six were associated with better cognitive health later in life, adherence to the DASH diet produced the strongest association, with participants showing roughly a 40% lower risk of subjective cognitive decline and stronger performance on objective cognitive testing. The protective relationship was strongest when healthy eating habits began during midlife. Host Dave Asprey breaks down why blood sugar control, lower inflammation, and healthier blood vessels may be the real drivers behind long-term brain resilience, and why your dietary choices in your 40s and 50s may have an outsized impact on cognitive aging decades later. Sources: https://jamanetwork.com/journals/jamaneurology/article-abstract/2845466 https://www.health.harvard.edu/diet-and-nutrition/harvard-study-six-healthy-diets-linked-with-better-long-term-brain-health https://www.eurekalert.org/news-releases/1117225 ~~ Scientists Identified an Ancient Brain Circuit That Filters Distractions Johns Hopkins researchers discovered a small population of inhibitory neurons within an evolutionarily ancient brainstem region that appears to control selective attention by determining which sensory information deserves focus and which distractions should be ignored. Mice trained on visual attention tasks consistently ignored irrelevant stimuli until researchers temporarily silenced these neurons, causing even weak distractions to hijack their attention while leaving vision and movement otherwise unaffected. Similar brain circuits exist in birds, reptiles, and other vertebrates, suggesting this attentional filtering system evolved long before the modern human cortex. Host Dave Asprey explains why attention may depend on much older brain circuitry than previously believed, how this discovery could reshape our understanding of ADHD and autism, and why future therapies may target the brainstem instead of the prefrontal cortex. Sources: https://www.sciencedaily.com/releases/2026/06/260624025426.htm ~~ Nearly Half of Older Adults Improved With Age Instead of Declining A Yale-led study followed 11,340 adults age 65 and older for up to 12 years using repeated measurements of cognition and walking speed to better understand how aging changes over time. Rather than finding universal decline, researchers discovered that 45% of participants improved in either cognitive function, physical performance, or both. Nearly one-third experienced measurable cognitive improvements, while over one-quarter improved physically. Researchers also found that participants with more positive beliefs about aging were significantly more likely to improve, even after accounting for education, chronic illness, depression, and other health factors. Host Dave Asprey explores why expectations about aging may become biologically embedded, why decline is far less inevitable than conventional medicine often assumes, and how mindset may directly influence healthy longevity. Sources: https://www.sciencedaily.com/releases/2026/06/260620100428.htm ~~ Glyphosate May Be Contributing to Antibiotic-Resistant Superbugs Researchers publishing in Frontiers in Microbiology examined 102 bacterial strains collected from hospitals, agricultural land, and protected wetlands to investigate whether glyphosate exposure contributes to multidrug antibiotic resistance. Hospital bacteria demonstrated extensive resistance to both antibiotics and glyphosate, while even bacteria living inside protected nature reserves displayed measurable glyphosate resistance despite no direct herbicide application. Genetic analysis suggested resistant bacterial strains may move between agricultural environments and hospitals through shared waterways and sediments. The researchers argue pesticide safety testing should also evaluate whether chemicals encourage antibiotic resistance, one of the world's fastest-growing public health threats. Host Dave Asprey explains why environmental toxins may have unintended effects on the human microbiome, how herbicides could influence antimicrobial resistance beyond farming, and why environmental biology increasingly belongs in conversations about human health. Sources: https://www.sciencedaily.com/releases/2026/06/260620100434.htm https://www.openaccessgovernment.org/common-weedkiller-glyphosate-linked-to-rise-in-superbugs-scientists-warn/207515/ ~~ Butterflies That Barely Age Could Unlock New Longevity Pathways Researchers from the University of Bristol found that Heliconius butterflies live dramatically longer than closely related butterfly species while aging much more slowly. In one comparison, Heliconius hewitsoni survived up to 348 days, while a closely related species lived only 14 days. Unlike most butterflies, Heliconius feed on pollen throughout adulthood, providing amino acids that help preserve muscle function and physical performance with age. However, even when pollen was removed, these butterflies still significantly outlived their relatives, suggesting evolved genetic and metabolic mechanisms also contribute to their exceptional longevity. Host Dave Asprey explores why nature continues to provide unexpected models for slowing biological aging, what scientists hope to learn from species that naturally maintain function over time, and how comparative biology may uncover entirely new pathways for extending human healthspan. Sources: https://www.sciencedaily.com/releases/2026/06/260622014302.htm ~~ This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want mechanism-level insights into omega-3 supplementation and Alzheimer's prevention, nutrition strategies for preserving cognitive health, newly discovered brain circuits controlling attention, the surprising biology behind healthy aging, environmental drivers of antibiotic resistance, and what one remarkably long-lived butterfly can teach us about extending healthspan. Host Dave Asprey connects randomized clinical trials, large population studies, neuroscience discoveries, microbiology research, and evolutionary biology into practical frameworks for improving brain performance, resilience, and longevity. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: fish oil Alzheimer's study, DHA supplements memory, omega-3 brain health, DASH diet cognition, dementia prevention diet, cognitive decline nutrition, selective attention brainstem, focus neuroscience, ADHD brain research, positive aging beliefs, healthy aging study, cognitive improvement older adults, glyphosate antibiotic resistance, superbugs glyphosate, environmental toxins microbiome, butterfly longevity research, Heliconius aging, longevity science, biohacking news 2026, Dave Asprey, The Human Upgrade Thank you to our sponsors! - Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today - Neuronic | Go to www.neuronic.online Code DAVE for $100 off - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:18 – Story #1 Fish Oil 02:31 – Story #2 DASH Diet 03:49 – Story #3 Brain Stem Attention Filter 05:59 – Story #4 Cognitive Decline Lies 08:24 – Story #5 Glyphosate 10:16 – Story #6 Butterfly Lifespan Research 12:16 – Biohacking Criticism Response See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
This week on the Roach Koach Podcast, Lorin and Matt celebrate the week of Roach Koach X by listening to some (fairly) new Nu with Of Mice & Men's 2014 album, Restoring Force. Topics this episode include:-Final push for Roach Koach X tickets!-Metalcore band line up changes-The trials of unclean vocalists-Good reviews-Changing your screams-“This riff is hard”-Going to jail for a fan-“You hear the screaming, we hear the meaning”-Public Service announcements-The hardest four years of your life-“If I could fuck the world”?-22 second screams-And Canon Talk, where Lorin and Matt decide if Of Mice & Men get a place in the Nu-Metal Canon.Take a listen!Roach Koach X is almost here! June 20th at Go Comedy Improv Theater in Ferndale Michigan. Tickets now on sale!
This week we talk about the negative consequences of invasive species. Music Provided By: Greg Gibbs / Most Guitars Are Made of Trees Winston / Valse Catastrophe
Elis is fresh from the jolly japes of being surprised with being made to do a headline set in front of 5,000 people at an iconic venue. He's just soooo totally cool about it.“Feel free to leave if it's bad, but give the guy a chance.” So if you want to miss the rush during the gig then stay til the end. John revives an old, and at times deeply criticised, feature. We also hear some more good old fashioned Common Zense, which helps us ask the question, if the Dalai Lama spilt coffee on an important letter would he be calm?Got any parabulation to send in? Well send it on the calm winds to hello@elisandjohn.comAnd please stick around til the end of the show.For more information on Pressure is a Privilege head here. And it's here for Don't Think So Somehow, and here for Skinwigs.For lots of exclusive EJJR #content, join our Patreon at patreon.com/elisandjohn.For weekly visual highlights, head to youtube.com/@elisandjohn.For everything else, head to elisandjohn.com.The Elis James and John Robins Show is a Significant Production. Hosted on Acast. See acast.com/privacy for more information.
Thanks to Smirnoff Ice, we welcome you back to another ad-free episode of Upstairs Neighbors! This week Dom and Maya talk about their vacation trips while away, an abundance mindset, and the potential condemnation of their favorite restaurant... Remy get cooking! Enjoy! *Drink Responsibly, 21+ Podcast Socials: IG: https://www.instagram.com/upstairsneighborspod/ TikTok: https://www.tiktok.com/@upstairsneighborspod Follow our Hosts: Maya IG: https://www.instagram.com/mayamoto_/ Maya TikTok: https://www.tiktok.com/@mayahasatiktok Dom IG: https://www.instagram.com/domrobxrts/ Dom TikTok: https://www.tiktok.com/@domnotateenmom Learn more about your ad choices. Visit megaphone.fm/adchoices
Jeremy Zakis details a burgeoning mouse plague in Western and South Australia, where mice are breeding rapidly and have become resilient to standard toxins. In response, the government has authorized farmers to double the dosage of zinc phosphide bait. This surge in prey has caused a corresponding increase in snake sightings, as predators forgo hibernation to feed. Most notably, a large red-bellied black snake was discovered living inside the walls of an emergency operating theater at John Hunter Hospital. Authorities were forced to close the theater to remove the snake, which had likely been eating local mice. (3/3)1927
Jeremy Zakis details a burgeoning mouse plague in Western and South Australia, where mice are breeding rapidly and have become resilient to standard toxins. In response, the government has authorized farmers to double the dosage of zinc phosphide bait. This surge in prey has caused a corresponding increase in snake sightings, as predators forgo hibernation to feed. Most notably, a large red-bellied black snake was discovered living inside the walls of an emergency operating theater at John Hunter Hospital. Authorities were forced to close the theater to remove the snake, which had likely been eating local mice. (3/3)1899 PERTH WA
This week, in Sidney, Montana, when a beloved local teacher disappears, after going for a morning run, all that's left behind is a running shoe, in a ditch. Luckily, a tip comes in that is very specific to one of the culprits. This tip leads to an unlikely pair, consisting of a large, dumb young man, and his smaller, craftier older friend. It seems that when the older man smokes a lot of crack he says "the devil gets in him", and this causes him to brutally murder a teacher, and also commit one of the dumbest acts that a murderer could ever think of!! Along the way, we find out that way too many towns are named after small children, that 3 day crack benders rarely result in anything productive, and that you should never return a murder tool to the store, so you can get a refund!! New episodes, every Wednesday & Friday nights!! Check us out on VIDEO Wednesday and Friday evenings on Netflix! www.netflix.com/smalltownmurder Donate at patreon.com/crimeinsports or at paypal.com and use our email: crimeinsports@gmail.com Go to shutupandgivememurder.com for all things Small Town Murder, Crime In Sports & Your Stupid Opinions! Follow us on... instagram.com/smalltownmurder facebook.com/smalltownpod Also, check out James & Jimmie's other shows, Crime In Sports & Your Stupid Opinions on Apple Podcasts, Spotify, or wherever you listen to podcasts!!