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Since it was seized from the Knights Templar in the 14th century, the Inner Temple in London has housed acolytes of a different sort: men (and eventually women) who serve as advocates of the law. Sally Smith spent her legal career—and now is spending her retirement—inside the 15 acres that comprise the Inner Temple, now one of the four Inns of Court. Smith has previously written non-fiction books about historical crimes and legal figures. When she decided to turn her hand to writing fiction, the familiar setting of the Inner Temple was the perfect setting for her new mystery novel, A Case of Mice and Men. Set in 1901, mere months after the death of Queen Victoria, A Case of Mice and Men introduces a new (and very reluctant) sleuth to the literary scene. Sir Gabriel Ward KC is happiest either when holed up in his Inner Temple lodgings with his books, or when making a compelling case in front of the High Court judges. A solitary, particular and cerebral man, Ward is not looking for excitement beyond the intellectual. But he finds it early one morning when he trips over the body of the Lord Chief Justice of England, which has been left on the doorstep of his professional chambers. The ancient privileges afforded to the Inner Temple mean that no policeman is allowed to enter without permission, and an aghast Ward is told he will conduct the investigation himself or be at risk of being kicked out of his lodgings. Unused to the world outside the Temple walls, or of conversing with any women apart from his old nanny or his mother, Ward must stretch himself to discover who killed Lord Norman Dunning. All the while, Ward is also wrestling with a knotty legal issue involving the rights to a bestselling children's book, and will need to exercise all his skills on behalf of his client, the publisher of Millie the Temple Church Mouse. Written by a mysterious author, the book has been a runaway success, bringing throngs of children to the Temple Church and spawning toys, games and an American publishing deal. Now that the author has reportedly surfaced and is demanding her share of the money and control of the intellectual property, what will happen to Millie the Temple Church Mouse? In this episode of the Modern Law Library, Smith and the ABA Journal's Lee Rawles discuss the launch of this new series, which will contain at least three books following Ward's adventures. Smith describes her own career as a barrister, and why she chose to set the series at the beginning of the Edwardian era. She also discusses the issues of class, gender and the complex world within the walls of the Inner Temple.
Since it was seized from the Knights Templar in the 14th century, the Inner Temple in London has housed acolytes of a different sort: men (and eventually women) who serve as advocates of the law. Sally Smith spent her legal career—and now is spending her retirement—inside the 15 acres that comprise the Inner Temple, now one of the four Inns of Court. Smith has previously written non-fiction books about historical crimes and legal figures. When she decided to turn her hand to writing fiction, the familiar setting of the Inner Temple was the perfect setting for her new mystery novel, A Case of Mice and Men. Set in 1901, mere months after the death of Queen Victoria, A Case of Mice and Men introduces a new (and very reluctant) sleuth to the literary scene. Sir Gabriel Ward KC is happiest either when holed up in his Inner Temple lodgings with his books, or when making a compelling case in front of the High Court judges. A solitary, particular and cerebral man, Ward is not looking for excitement beyond the intellectual. But he finds it early one morning when he trips over the body of the Lord Chief Justice of England, which has been left on the doorstep of his professional chambers. The ancient privileges afforded to the Inner Temple mean that no policeman is allowed to enter without permission, and an aghast Ward is told he will conduct the investigation himself or be at risk of being kicked out of his lodgings. Unused to the world outside the Temple walls, or of conversing with any women apart from his old nanny or his mother, Ward must stretch himself to discover who killed Lord Norman Dunning. All the while, Ward is also wrestling with a knotty legal issue involving the rights to a bestselling children's book, and will need to exercise all his skills on behalf of his client, the publisher of Millie the Temple Church Mouse. Written by a mysterious author, the book has been a runaway success, bringing throngs of children to the Temple Church and spawning toys, games and an American publishing deal. Now that the author has reportedly surfaced and is demanding her share of the money and control of the intellectual property, what will happen to Millie the Temple Church Mouse? In this episode of the Modern Law Library, Smith and the ABA Journal's Lee Rawles discuss the launch of this new series, which will contain at least three books following Ward's adventures. Smith describes her own career as a barrister, and why she chose to set the series at the beginning of the Edwardian era. She also discusses the issues of class, gender and the complex world within the walls of the Inner Temple. Learn more about your ad choices. Visit megaphone.fm/adchoices
Since it was seized from the Knights Templar in the 14th century, the Inner Temple in London has housed acolytes of a different sort: men (and eventually women) who serve as advocates of the law. Sally Smith spent her legal career—and now is spending her retirement—inside the 15 acres that comprise the Inner Temple, now one of the four Inns of Court. Smith has previously written non-fiction books about historical crimes and legal figures. When she decided to turn her hand to writing fiction, the familiar setting of the Inner Temple was the perfect setting for her new mystery novel, A Case of Mice and Men. Set in 1901, mere months after the death of Queen Victoria, A Case of Mice and Men introduces a new (and very reluctant) sleuth to the literary scene. Sir Gabriel Ward KC is happiest either when holed up in his Inner Temple lodgings with his books, or when making a compelling case in front of the High Court judges. A solitary, particular and cerebral man, Ward is not looking for excitement beyond the intellectual. But he finds it early one morning when he trips over the body of the Lord Chief Justice of England, which has been left on the doorstep of his professional chambers. The ancient privileges afforded to the Inner Temple mean that no policeman is allowed to enter without permission, and an aghast Ward is told he will conduct the investigation himself or be at risk of being kicked out of his lodgings. Unused to the world outside the Temple walls, or of conversing with any women apart from his old nanny or his mother, Ward must stretch himself to discover who killed Lord Norman Dunning. All the while, Ward is also wrestling with a knotty legal issue involving the rights to a bestselling children's book, and will need to exercise all his skills on behalf of his client, the publisher of Millie the Temple Church Mouse. Written by a mysterious author, the book has been a runaway success, bringing throngs of children to the Temple Church and spawning toys, games and an American publishing deal. Now that the author has reportedly surfaced and is demanding her share of the money and control of the intellectual property, what will happen to Millie the Temple Church Mouse? In this episode of the Modern Law Library, Smith and the ABA Journal's Lee Rawles discuss the launch of this new series, which will contain at least three books following Ward's adventures. Smith describes her own career as a barrister, and why she chose to set the series at the beginning of the Edwardian era. She also discusses the issues of class, gender and the complex world within the walls of the Inner Temple.
In this episode of The Homeowners Show, we're getting our hands dirty—in the best way possible. First, we break down California's latest Defensible Space initiative and what it means for homeowners looking to protect their property from wildfires. Learn the new rules, how to comply, and smart ways to turn your yard into a fire-safe zone without sacrificing curb appeal. Then we shift gears (and gears snap!) as we talk classic mouse traps. Whether you're battling a sneaky kitchen invader or just prepping for winter, we'll walk you through how to properly set, place, and maintain traps that actually work—plus some pro tips to keep rodents from coming back. Lone Star Appliance Repair - 936-647-2364 – Give them a call for all your appliance repair needs. Their staff is the best in the business and can help get you squared away with all of your appliance repairs. True Texas Solar – 936-286-8325 – Give True Texas Solar a call if you would like to learn how your home or business would benefit from solar. There are tons of incentives available, and they are experts in owning your energy! Krazy Klean – never scrub your toilet again with this chemical-free solution for your toilet. Buy a Homeowners Show T-Shirt! Subscribe to our YouTube Channel The Homeowners Show Website The Homeowners Show Facebook Page Instagram @homeownersshow Twitter @HomeownersThe Info@homeownersshow.com Sustained Growth Solutions – Design a lead generation system specifically for your business so that you never have to search for leads again! We are a full digital marketing agency.
We are allowed one non bookish episode a year, right?Links mentioned:"Tech Gone Wrong" Books: https://bookshop.org/lists/tech-gone-wrong"Tech Gone Wrong" Audiobooks: https://libro.fm/playlists/9673?bookstore=bissettbooksSupport The Podcast:Join our patreon and become a Dust Jacket! patreon.com/booksunboundSign up to the bookmark subscription! https://store.dftba.com/products/books-unbound-bookmark-subscriptionOur beautiful merch: https://store.dftba.com/collections/books-unboundAriel's T-shirt: https://store.dftba.com/collections/bissett-books/products/im-thinking-about-books-t-shirtFollow us on instagram: https://www.instagram.com/books_unbound/Need Info or Some Books?Buy books with our affiliate link: https://bookshop.org/shop/BooksUnboundAll the books we mentioned in this episode: https://www.booksunboundpodcast.com/booksSubmit your book requests at booksunboundpodcast.comUse our affiliate link to get 2 audiobooks for the price of 1! https://tidd.ly/3dyW1XwOur Patrons:A special thanks to our Gold Foil Team on Patreon: Abigail, Adriane, Alex, Bellanora, Brittany, Bronte, Candis, Christina, Claire, Debra, Diana, Gene, Hannah, Inbar, Jessie, Jill, Karina, Livi, Luna, Megan, Michelene, Myriam, Nicole, Phoebe, Roisin, Sherralle, Tiffany, Tina, Vanessa, Zoe!
This week on Sneople, the Sneople cover a genre proves a little tricky to define, spans movies, tv, books, and comics, and incites an argument (or two) amongst our hosts - Urban Fantasy! This episode starts, as many do, with definitions - what exactly makes an urban fantasy movie, and how is it different from straight up monster movies or something with fantasy elements that takes place in modern times? After a quick but decisive discussion, the Sneople move onto some of their favorites of the genre, dig through multiple lists of “urban fantasy” media to decide if they actually count as part of the genre, and get into why it's so hard to make urban fantasy work on film. They also, as always, get severely off topic, look at a lot of weird wiki pages, and learn about new weird stuff that they now obviously have to read/watch. Not necessarily in that order. If you disagree with their definition of urban fantasy and/or want to submit recs for good urban fantasy to read or watch, their email inbox is always open. Keep in mind that they are extremely right about what urban fantasy is, but arguing is still fun anyway!
Barbara Peters in conversation with Sally Smith
This week on One Song, Diallo and LUXXURY are resharing a special "thank you" episode in honor of the late musical genius Sylvester Stewart aka Sly Stone. In this episode, they discuss Sly and The Family Stone's 1970 classic "Thank You (Falettinme Be Mice Elf Agin)" with a very special guest – Sly's xdaughter, DJ and KCRW radio host Novena Carmel. Learn more about your ad choices. Visit megaphone.fm/adchoices
Christina Donati joins the Exchange.
Según un estudio de AliExpress, los españoles se encuentran entre los europeos que más anticipan sus compras para las vacaciones de verano, con una media de más de cuatro semanas de antelación, superando a países como Alemania o Italia. Navarra es la región más previsora, mientras que Murcia es la que menos planifica.PortAventura World ha celebrado su 30º aniversario con un acto institucional que reunió a representantes del ámbito político, empresarial y cultural. Desde su apertura en 1995, el parque ha recibido más de 100 millones de visitas y se ha consolidado como referente en turismo y ocio en Europa, destacando por su impacto económico y social en Cataluña, con un 12% del PIB de Tarragona y más de 24.000 empleos generados anualmente.Edreams ha lanzado una emisión de bonos por 375 millones de euros con vencimiento en 2030, con el objetivo de cancelar anticipadamente una deuda anterior del mismo importe que vencía en 2027. La operación forma parte de su estrategia de reestructuración financiera tras años de fuerte crecimiento turístico. Además, la compañía prevé alcanzar los 8,25 millones de suscriptores a su programa Prime en 2025, sumando un millón de nuevos clientes.World2Meet, la división de viajes del Grupo Iberostar, ha sellado una alianza estratégica con la Autoridad de Turismo de Arabia Saudí para promover el país de Oriente Próximo entre los viajeros españoles. La propuesta contempla un enfoque transversal que abarca todas las marcas y líneas de negocio del grupo, incluyendo el turismo vacacional, los viajes corporativos y el segmento MICE.El Gobierno central, la Generalitat de Cataluña y Aena han alcanzado un acuerdo para ampliar el aeropuerto de Barcelona-El Prat con una inversión de 3.200 millones de euros y tras cuatro años de negociaciones. El plan incluye la prolongación de la pista cercana al mar, una nueva terminal satélite y reformas en las actuales, con el objetivo de reforzar su papel como hub internacional, aunque el proyecto sigue generando controversia.
Following their new friends the Krew find themselves on a treacherous path... Gain access to an exclusive campaign, Shroud Over Saltmarsh, over on Patreon: https://legendsofavantris.com/patreon The Crooked Moon, a folk horror supplement for 5e, is available for preorder! Get the Crooked Moon at: https://thecrookedmoon.com/ Watch more D&D adventures in the world of Avantris live on Twitch: https://www.twitch.tv/legendsofavantris Check out our merch store: https://shop.legendsofavantris.com Join our community on Discord: https://legendsofavantris.com/discord Watch our many campaigns on YouTube: https://legendsofavantris.com/youtube All other links: https://linktr.ee/legendsofavantris Watch the full episode here: https://youtu.be/rLLfmXC0Wnk?si=F6F-tWRQy1Fy-7rw
Es tracta d'un fòrum professional de referència en l'àmbit estatal que comptarà amb més de 50 agències organitzadores d'esdeveniments.
Join us on the podcast today as we learn from two of our amazing conservation experts, Alyssa Rice and Kelly Currier! These beach mice experts fill us in on what it takes to care for dozens of Perdido Key Beach Mice, a species that is at our Zoo as part of an essential conservation breeding program. Learn all about these rare mice and how we are helping to save them from extinction!
Ben Lamm is an entrepreneur and the founder and CEO of Colossal Biosciences. That's the genetic engineering company making headlines for its bold mission – bringing extinct species back to life. From dire wolf pups to woolly mice, Colossal’s breakthroughs have sparked awe and controversy. Lamm sits down with Oz to unpack the science behind de-extinction, the ethical questions it raises, and what it could mean for the future of conservation.See omnystudio.com/listener for privacy information.
00:45 Iron's role in mice sex determinationIron deficiency in mice mothers can sometimes result in their offspring developing female sex organs despite having male sex genes, according to new research. While genetics has been thought to be the primary factor in determining offspring sex in mammals, the new work shows that a lack of iron disrupts an enzyme involved in the development of testes, leading to some mice with male sex-determining genes being born with female genitalia and ovaries. This suggests that sex determination is controlled by more than genetics, but more work will need to be done to understand the precise mechanisms involved.News: Male mice can grow ovaries if their pregnant mums are iron deficientResearch article: Okashita et al.06:31 Research HighlightsHow climate change is making dust storms more likely, and understanding the genetics of a boy who couldn't feel pain.Research Highlight: The perfect storm for dust storms, thanks to global warmingResearch Highlight: CRISPR helps to show why a boy felt no pain08:51 The role of small-scale fishers in sustainabilityThe contributions that small-scale fishers make to sustainable fishing have been described as ‘invisible', but now a huge research project has revealed the role this community plays in feeding populations and protecting oceans. Looking at data from 58 countries, researchers have shown that small-scale fishers account for around 40% of the global catch and feed approximately 25% of the world's population. The people behind the initiative hope that these data can help give a voice to small-scale fishers as people look for ways to feed the world sustainably.Immersive : Small-scale fisheries19:44 Briefing ChatThe discovery of an ‘ambidextrous' protein; and why humpback whales, despite their enormous eyes, appear to be shortsighted.Nature: Rare ‘ambidextrous' protein breaks rules of handednessDiscover Magazine: Big Eyes, Blurry Vision: Why Humpback Whales Struggle to See ClearlySubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.
2 sections- further cases (Rava) of mice bringing chametz into house/chametz in inaccessible places and psakim/doubts, debate regarding latest time one is obligated to do bedikas chametz (between chatzos of 14th and nightfall)
2 sections- further cases (Rava) of mice bringing chametz into house/chametz in inaccessible places and psakim/doubts, debate regarding latest time one is obligated to do bedikat chametz (between chatzot of 14th and nightfall)
1 section- 7 more cases (total 9) in which a doubt arises about rechecking a house that has been checked because of outside factors (mouse, movement) and the resolutions based on sources
The interpeduncular nucleus produces an aversion to nicotine, even at low doses, and helps moderate how rewarding mice find the drug.
Story at-a-glance A high-fat diet makes it easier for breast cancer to spread by activating clotting cells, increasing inflammation and altering blood vessels in ways that help tumors grow Mice on high-fat diets had nearly five times more cancer cells in their lungs, even when their tumors were the same size as leaner mice A high-fat diet increased fibronectin, which acts as "molecular glue" helping cancer cells attach to blood vessels, while obesity increases inflammatory compounds that worsen this buildup Switching to a normal-fat diet for just seven days significantly reduced clotting activity, fibronectin buildup and the number of cancer cells lodging in the lungs Eliminating vegetable oils and reducing total fat intake to 30% to 40% of daily calories lowers inflammation and reduces your risk of cancer spread
BUFFALO, NY — June 3, 2025 — A new #research paper was #published in Aging (Aging-US) on May 1, 2025, as the #cover of Volume 17, Issue 5, titled “Defining the hypoxic thresholds that trigger blood-brain barrier disruption: the effect of age.” In this study, researchers Arjun Sapkota, Sebok K. Halder, and Richard Milner from San Diego Biomedical Research Institute investigated how aging affects the brain's vulnerability to low oxygen, or hypoxia. Using C57BL/6J mice ranging from 2 to 23 months of age, they identified specific oxygen levels that disrupt the blood-brain barrier (BBB)—a critical structure that protects brain tissue from harmful substances. The findings are important for understanding age-related cognitive decline and the potential risks faced by individuals with chronic oxygen-limiting conditions such as asthma, sleep apnea, emphysema, and heart disease. The BBB is essential for maintaining brain health. In this study, mild and prolonged hypoxia—called chronic mild hypoxia—was found to compromise the BBB in mice. Older mice showed significantly more BBB disruption than younger ones. Notably, barrier weakening and blood vessel changes occurred at oxygen levels of just 15% in aged mice, compared to 13% in young mice. These data suggest that the aging brain is more sensitive to oxygen deprivation, even at levels that may be considered only mildly hypoxic. The researchers also determined when this vulnerability emerged. The BBB showed increased sensitivity to low oxygen not only in aged mice but also in mice as young as 2 to 6 months, with a second spike occurring between 12 and 15 months—equivalent to middle age in mice. These findings may reflect age-dependent changes in brain vascular function and remodeling capacity. “Hypoxia-induced endothelial proliferation was relatively constant across the age range, but advanced age strongly enhanced the degree of BBB disruption (4-6-fold greater in 23 months vs. 2 months old).” Another key focus was microglial activation, a sign of brain inflammation. Aged mice exhibited higher microglial activation across all oxygen levels, including normal conditions. Chronic microglial activation is closely linked to neuroinflammation and has been implicated in diseases such as Alzheimer's. While the rate of blood vessel formation was constant across ages, the degree of BBB disruption increased sharply with age, suggesting that repair mechanisms may weaken over time. These results may help explain why older adults with chronic hypoxia-related diseases are at higher risk for neurodegeneration and cognitive decline. The study also draws attention to the risks of high-altitude exposure for aging populations, where oxygen levels naturally drop. Altogether, these findings underscore the importance of protecting brain health in older individuals by managing oxygen exposure and reducing hypoxia-related risks. The researchers emphasize the need to develop new therapies that support blood-brain barrier integrity, particularly in aging populations exposed to chronic or intermittent low-oxygen conditions. DOI - https://doi.org/10.18632/aging.206241 Corresponding author - Richard Milner - rmilner@sdbri.org Video short - https://www.youtube.com/watch?v=Nr6rTm7aJRo Keywords - aging, blood-brain barrier integrity, endothelial, proliferation, microglia, chronic mild hypoxia, hypoxic threshold To learn more about the journal, please visit our website at https://www.Aging-US.com and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM
2 sections- storing away chametz found after bedika will prevent an issue from causing a need for recheck, 2 halachot about mice bringing chametz into checked areas and psakim if need recheck or not based on klalim of resolving doubts
2 sections- storing away chametz found after bedika will prevent an issue from causing a need for recheck, 2 halachos about mice bringing chametz into checked areas and psakim if need recheck or not based on klalim of resolving doubts
Massimo Rigotti ~ https://sobermethod.com/
Story at-a-glance A recent study shows that sucralose activates brain regions tied to hunger and food motivation, leaving your body in a state of confusion that increases cravings instead of curbing them Sucralose alters connections between the hypothalamus and anterior cingulate cortex — brain regions that weigh risks and rewards — leading to stronger urges to eat, especially in women and those with obesity Unlike sucrose, sucralose failed to increase insulin and GLP-1 — hormones that signal fullness — resulting in a body that thinks it's eaten but gets no confirmation from key metabolic pathways Just 10 weeks of sucralose use was enough to trigger gut dysbiosis in healthy adults, with a measurable impact on insulin sensitivity and a rise in inflammation linked to liver and colon issues Mice fed sucralose at levels considered “safe” were less able to fight infection and cancer due to impaired T cell activation — effects that reversed only after sucralose was removed from their diet
I have been making taxidermy for about 8 years now, but I'm not sure if you have seen the little stories I write for some of my items. This is a way of me reusing some of that stuff to try and get monetised on Youtube. If you want to watch things like this early and get access to loads of exclusive content join the patreon - www.patreon.com/worldaroundewe If you want to find what I have available at the moment look on my website www.worldaroundewe This is the first episode, so I plan on it being on Patreon initially for a few days, then I will release it as a video on Youtube publically and as audio on my podcast feeds. so if you would like to see the video version go to my Youtube.
Donald Hebb's theory—memorably summarized as “cells that fire together, wire together”—does not explain the shifting hippocampal connections in mice learning to navigate a virtual environment, according to a new study.
Aporte universitario a reuniones MICE.
You've no quarrel with most mice… just the ones that are invading your home! That said, trying to deal with them yourself is a lot harder than it seems. Call Connor's Pest Pros (888-284-6968) or go to https://connorspestpros.com/locations/pest-control-mclean/ Connor's Pest Pros City: Springfield Address: 5410 Port Royal Rd Website: https://connorspestpros.com/contact/ Phone: +1 888 284 6968
MICKEY AIN'T MICE: Disney Pulls Up on YouTube for Stealing the OpsIn a plot twist straight outta a corporate telenovela, Disney just hit YouTube with the ultimate cease and desist vibes. Why? ‘Cause YouTube — aka Google's chaotic little sibling — yoinked one of Disney's top ops: Justin Connolly, the dude who basically had Mickey's whole war map in his brain.Homie wasn't just any suit — he was the President of Platform Distribution, aka the guy who knew everything about Disney's bag, deals, strategies, and future plays. Right before he dipped, he was even handling licensing talks with YouTube. And now? Bro's the new head of sports/media… at YouTube. Suspicious? Mickey thinks so too.Disney's lawyers pulled up like:“Your Honor, this is not just job-hopping. This is high-level intel robbery with a side of breach of contract.”They basically told the court:“Justin's got the whole playbook. We're tryna launch our ESPN streaming beast, YouTube's out here copping NFL rights — it's not giving fair play.”So now Disney's suing to block him from even working at YouTube, and they want the court to ice out anything that smells like leaked secrets. No cap, this could change the way execs hop jobs in the whole industry.While Mickey's loading legal papers like Infinity Stones, the rest of the media world's eating popcorn watching two titans throw hands over a power move that might decide the future of sports streaming.
In this episode, we're joined by Mrs. Sherin Francis, Principal Secretary of the Department of Tourism in Seychelles, as she shares insights on the country's historic hosting of the FIFA Beach Soccer World Cup Seychelles 2025. She discusses how this landmark event is poised to boost the island's ambitions in the MICE sector and support the development of a policy framework positioning Seychelles as a premier destination for major international events. Mrs. Francis also delves into the current state of tourism, efforts in product diversification, and the unique charm of Seychelles that goes far beyond its iconic beaches.
Regulatory T cells in the spinal meninges release endogenous opioids in a sex-specific manner, new work shows.
This week Craig and Alex review Of Mice and Men, learn if we want to try new things and tell you about every ranking a movie can get! Next week we're watching Being John Malkovich!
Cue the freaky deaky theremin music, because this week the Idiots talk toxoplasmosis, an infection that lives in cat poo (and unwashed veggies and undercooked meat) that affects brains. All mammals can be affected, but rats and mice are affected the most. However, humans can also be greatly affected. Listen this week to learn more about this disease, and to find out you may actually already have it.... Anyway, sources https://www.vet.cornell.edu/departments-centers-and-institutes/cornell-feline-health-center/health-information/feline-health-topics/toxoplasmosis-cats https://www.cdc.gov/parasites/toxoplasmosis/resources/printresources/catowners_2017.pdf https://www.merckvetmanual.com/cat-owners/disorders-affecting-multiple-body-systems-of-cats/toxoplasmosis-in-cats
Cystic Fibrosis and obesity? Until recently this has not been a topic of conversation for the CF community. The reason for obesity in the CF community is better health and longer lives, so the concern is now a reality. University of Michigan CF doctor, Carey Lumeng is researching the issue. As he says in this podcast, researchers have a lot to learn about the connection between better health in CF and obesity. We also talk about The Bonnell Foundation fellowship program. A few years ago we started the program to encourage doctors to work in the specialty field of cystic fibrosis. Dr. Lumeng is one of the doctors who oversees this program.Dr. Lumeng is the Frederick G.L. Huetwell Professor for the Cure and Prevention of Birth Defects and Professor in Pediatrics and Molecular and Integrative Physiology. Dr. Lumeng is the Division Chief of Pediatric Pulmonology at the C.S. Mott Children's Hospital and Associate Director of the Michigan MSTP Program.He grew up in Indiana and graduated from Princeton University in Molecular Biology. He received his PhD in Human Genetics and MD from the University of Michigan and completed residency training in Pediatrics in the Boston Combined Pediatrics Residency Program at Boston Children's Hospital and Boston Medical Center. He then completed fellowship training in Pediatric Pulmonology at the University of Michigan and started as faculty in 2006. He runs a research lab focused on the health effects of obesity and the links between metabolism and lung health. The laboratory participates in both basic science and translational research projects in adult and pediatric obesity. He is funded by the NIH and the CF Foundation for new projects studying the changing causes of diabetes in people with CF.To contact the CF pediatric department (the Bonnell girls are pictured on this page): https://www.mottchildren.org/conditions-treatments/cystic-fibrosis-pediatric?pk_vid=6ff46bd2d38fe04c1739891353f5b28b Please like, subscribe, and comment on our podcasts!Please consider making a donation: https://thebonnellfoundation.org/donate/The Bonnell Foundation website:https://thebonnellfoundation.orgEmail us at: thebonnellfoundation@gmail.com Watch our podcasts on YouTube: https://www.youtube.com/@laurabonnell1136/featuredThanks to our sponsors:Vertex: https://www.vrtx.comViatris: https://www.viatris.com/en
Mice are used as model organisms across a wide range of fields in science today--but it is far from obvious how studying a mouse in a maze can help us understand human problems like alcoholism or anxiety. How do scientists convince funders, fellow scientists, the general public, and even themselves that animal experiments are a good way of producing knowledge about the genetics of human behavior? In Model Behavior: Animal Experiments, Complexity, and the Genetics of Psychiatric Disorders (U Chicago Press, 2018), Nicole C. Nelson takes us inside an animal behavior genetics laboratory to examine how scientists create and manage the foundational knowledge of their field. Behavior genetics is a particularly challenging field for making a clear-cut case that mouse experiments work, because researchers believe that both the phenomena they are studying and the animal models they are using are complex. These assumptions of complexity change the nature of what laboratory work produces. Whereas historical and ethnographic studies traditionally portray the laboratory as a place where scientists control, simplify, and stabilize nature in the service of producing durable facts, the laboratory that emerges from Nelson's extensive interviews and fieldwork is a place where stable findings are always just out of reach. The ongoing work of managing precarious experimental systems means that researchers learn as much--if not more--about the impact of the environment on behavior as they do about genetics. Model Behavior offers a compelling portrait of life in a twenty-first-century laboratory, where partial, provisional answers to complex scientific questions are increasingly the norm. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network
Mice are used as model organisms across a wide range of fields in science today--but it is far from obvious how studying a mouse in a maze can help us understand human problems like alcoholism or anxiety. How do scientists convince funders, fellow scientists, the general public, and even themselves that animal experiments are a good way of producing knowledge about the genetics of human behavior? In Model Behavior: Animal Experiments, Complexity, and the Genetics of Psychiatric Disorders (U Chicago Press, 2018), Nicole C. Nelson takes us inside an animal behavior genetics laboratory to examine how scientists create and manage the foundational knowledge of their field. Behavior genetics is a particularly challenging field for making a clear-cut case that mouse experiments work, because researchers believe that both the phenomena they are studying and the animal models they are using are complex. These assumptions of complexity change the nature of what laboratory work produces. Whereas historical and ethnographic studies traditionally portray the laboratory as a place where scientists control, simplify, and stabilize nature in the service of producing durable facts, the laboratory that emerges from Nelson's extensive interviews and fieldwork is a place where stable findings are always just out of reach. The ongoing work of managing precarious experimental systems means that researchers learn as much--if not more--about the impact of the environment on behavior as they do about genetics. Model Behavior offers a compelling portrait of life in a twenty-first-century laboratory, where partial, provisional answers to complex scientific questions are increasingly the norm. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/medicine
Mice are used as model organisms across a wide range of fields in science today--but it is far from obvious how studying a mouse in a maze can help us understand human problems like alcoholism or anxiety. How do scientists convince funders, fellow scientists, the general public, and even themselves that animal experiments are a good way of producing knowledge about the genetics of human behavior? In Model Behavior: Animal Experiments, Complexity, and the Genetics of Psychiatric Disorders (U Chicago Press, 2018), Nicole C. Nelson takes us inside an animal behavior genetics laboratory to examine how scientists create and manage the foundational knowledge of their field. Behavior genetics is a particularly challenging field for making a clear-cut case that mouse experiments work, because researchers believe that both the phenomena they are studying and the animal models they are using are complex. These assumptions of complexity change the nature of what laboratory work produces. Whereas historical and ethnographic studies traditionally portray the laboratory as a place where scientists control, simplify, and stabilize nature in the service of producing durable facts, the laboratory that emerges from Nelson's extensive interviews and fieldwork is a place where stable findings are always just out of reach. The ongoing work of managing precarious experimental systems means that researchers learn as much--if not more--about the impact of the environment on behavior as they do about genetics. Model Behavior offers a compelling portrait of life in a twenty-first-century laboratory, where partial, provisional answers to complex scientific questions are increasingly the norm. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science
Mice are used as model organisms across a wide range of fields in science today--but it is far from obvious how studying a mouse in a maze can help us understand human problems like alcoholism or anxiety. How do scientists convince funders, fellow scientists, the general public, and even themselves that animal experiments are a good way of producing knowledge about the genetics of human behavior? In Model Behavior: Animal Experiments, Complexity, and the Genetics of Psychiatric Disorders (U Chicago Press, 2018), Nicole C. Nelson takes us inside an animal behavior genetics laboratory to examine how scientists create and manage the foundational knowledge of their field. Behavior genetics is a particularly challenging field for making a clear-cut case that mouse experiments work, because researchers believe that both the phenomena they are studying and the animal models they are using are complex. These assumptions of complexity change the nature of what laboratory work produces. Whereas historical and ethnographic studies traditionally portray the laboratory as a place where scientists control, simplify, and stabilize nature in the service of producing durable facts, the laboratory that emerges from Nelson's extensive interviews and fieldwork is a place where stable findings are always just out of reach. The ongoing work of managing precarious experimental systems means that researchers learn as much--if not more--about the impact of the environment on behavior as they do about genetics. Model Behavior offers a compelling portrait of life in a twenty-first-century laboratory, where partial, provisional answers to complex scientific questions are increasingly the norm. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/psychology
Mice are used as model organisms across a wide range of fields in science today--but it is far from obvious how studying a mouse in a maze can help us understand human problems like alcoholism or anxiety. How do scientists convince funders, fellow scientists, the general public, and even themselves that animal experiments are a good way of producing knowledge about the genetics of human behavior? In Model Behavior: Animal Experiments, Complexity, and the Genetics of Psychiatric Disorders (U Chicago Press, 2018), Nicole C. Nelson takes us inside an animal behavior genetics laboratory to examine how scientists create and manage the foundational knowledge of their field. Behavior genetics is a particularly challenging field for making a clear-cut case that mouse experiments work, because researchers believe that both the phenomena they are studying and the animal models they are using are complex. These assumptions of complexity change the nature of what laboratory work produces. Whereas historical and ethnographic studies traditionally portray the laboratory as a place where scientists control, simplify, and stabilize nature in the service of producing durable facts, the laboratory that emerges from Nelson's extensive interviews and fieldwork is a place where stable findings are always just out of reach. The ongoing work of managing precarious experimental systems means that researchers learn as much--if not more--about the impact of the environment on behavior as they do about genetics. Model Behavior offers a compelling portrait of life in a twenty-first-century laboratory, where partial, provisional answers to complex scientific questions are increasingly the norm. Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/science-technology-and-society
Exposure to inorganic arsenic before conception can trigger changes in gene activity that are passed down to offspring and increase their risk of developing diabetes, according to a study in mice funded by an NIEHS individual research grant and by the NIEHS Superfund Research Program. These changes, known as epigenetic changes, alter how genes work without changing the genes themselves. In this study, the researchers looked at a type of change called CpG methylation.
In this thrilling installment of Impact Theory, Tom Bilyeu sits down with Ben Lamm, visionary founder and CEO of Colossal Biosciences, a company on a mission to reverse extinction and rewrite the future of conservation and synthetic biology. Ben and Tom dive deep into the mind-bending world of de-extinction, synthetic gene editing, and how the CRISPR revolution is not only unlocking the secrets of life—but also actively engineering it. In Part 1, get ready for a rollercoaster of concepts as Ben explains the technical magic behind gene editing, DNA synthesis, and multiplex genome editing. From the birth of the woolly mouse to the debated revival of dire wolves, Ben reveals the breakthroughs, challenges, and wild stories behind reviving extinct species. You'll learn how Colossal is using advanced computational biology, AI, and hands-on bioengineering to not only bring animals back but also reshape the future of healthcare, genetics, and ethical decision-making. This is part sci-fi, part practical science, and 100% mind-blowing. SHOWNOTES 00:00 – Kicking Off: The Mysteries of Editing Life 00:14 – Emergence of the CRISPR Revolution 01:31 – What Is DNA Synthesis and Multiplex Editing? 03:47 – The Woolly Mouse: Engineering Traits Across Species 07:54 – Breaking Down the Process: IVF, Screening, and Sequencing 09:24 – Mapping Genotype to Phenotype and Its Challenges 12:10 – Targeting Gene Edits: From Theory to Application in Health and Conservation 17:09 – From Hair Organoids to Building Mammoth Traits in Mice 24:41 – The Quest for a Universal Egg and Overcoming Cellular Barriers 26:17 – Artificial Wombs: The Next Frontier in Conservation and Science 31:12 – Scaling Conservation and Bridging to Human Healthcare FOLLOW BEN LAMM Twitter/X: @federallamm LinkedIn: Ben Lamm CHECK OUT OUR SPONSORS ButcherBox: Ready to level up your meals? Go to https://ButcherBox.com/impact to get $20 off your first box and FREE bacon for life with the Bilyeu Box! Vital Proteins: Get 20% off by going to https://www.vitalproteins.com and entering promo code IMPACT at check out Shopify: Sign up for your one-dollar-per-month trial period at https://shopify.com/impact Netsuite: Download the CFO's Guide to AI and Machine Learning at https://NetSuite.com/THEORY iTrust Capital: Use code IMPACTGO when you sign up and fund your account to get a $100 bonus at https://www.itrustcapital.com/tombilyeu Mint Mobile: If you like your money, Mint Mobile is for you. Shop plans at https://mintmobile.com/impact. DISCLAIMER: Upfront payment of $45 for 3-month 5 gigabyte plan required (equivalent to $15/mo.). New customer offer for first 3 months only, then full-price plan options available. Taxes & fees extra. See MINT MOBILE for details. What's up, everybody? It's Tom Bilyeu here: If you want my help... STARTING a business: join me here at ZERO TO FOUNDER SCALING a business: see if you qualify here. Get my battle-tested strategies and insights delivered weekly to your inbox: sign up here. ********************************************************************** If you're serious about leveling up your life, I urge you to check out my new podcast, Tom Bilyeu's Mindset Playbook —a goldmine of my most impactful episodes on mindset, business, and health. Trust me, your future self will thank you. ********************************************************************** LISTEN TO IMPACT THEORY AD FREE + BONUS EPISODES on APPLE PODCASTS: apple.co/impacttheory ********************************************************************** FOLLOW TOM: Instagram: https://www.instagram.com/tombilyeu/ Tik Tok: https://www.tiktok.com/@tombilyeu?lang=en Twitter: https://twitter.com/tombilyeu YouTube: https://www.youtube.com/@TomBilyeu Learn more about your ad choices. Visit megaphone.fm/adchoices
Good Noise Podcast discuss new releases from Acres, PUP, Tetrarch, Sleep Token, Turnstile, Loathe, Of Mice & Men, Belmont, and more.Grab some GNP Merch!: https://goodnoisepodcast.creator-spring.com/Check out the recording gear we use: https://www.amazon.com/shop/goodnoisepodcastSupport the show on Patreon: https://www.patreon.com/goodnoisepodcastGood Noise Podcast Socials:Twitter: https://twitter.com/good_noise_castInstagram: https://www.instagram.com/goodnoisepodcast/Facebook: https://www.facebook.com/goodnoisepodDiscord: https://discord.gg/nDAQKwTYouTube: https://www.youtube.com/channel/UCFHKPdUxxe1MaGNWoFtjoJASpotify: https://open.spotify.com/show/04IMtdIrCIvbIr7g6ttZHiAll other streaming platforms: https://linktr.ee/goodnoisepodcastBandcamp: https://goodnoiserecords.bandcamp.com/
This is a free preview of a paid episode. To hear more, visit smokeempodcast.substack.comPoet and author Nick Flynn joins Nancy and Sarah to talk about poems that blew his mind, the destabilizing experience of watching your life re-enacted in a movie (his memoir Another Bullshit Night in Suck City became Being Flynn with Robert DeNiro, Julianne Moore, and Paul Dano), why DeNiro demanded Nick be on set, riding in a limo to said set with the young Dano, and why white male writers are alive and well, at least in the classes he teaches.“The poets I've met are assholes,” Sarah confesses to Nick, although upon further reflection, it's more like the assholes really stand out. Nick isn't friends with assholes, but he does know many amazing poets, including Marie Howe, who just won the Pulitzer. Also discussed:* Sarah hates poetry, then proceeds to recite poetry* Nick defends Robert Frost* Pantyhose vending machines at Hooters* The surprising diversity, art/dining scene of Houston* Nick reads “Bag of Mice,” blows our minds* “Aristotle did not promise writing would be cathartic”* The greatness of Lili Taylor, better known to Nick as his wife* Who will play Nancy in the movie?* What's Amy Adams doing in, oh-say, two or three years?* Houston museums! Iranian films! Barn dance! * Sinners is a must-see, but…* … not a lot of love for Black Panther on this podcastPlus, Nick yells at a marriage therapist, why making stuff is dangerous, a rare sighting of Nancy's daughter in the wild, and much more!Two roads diverged in a yellow wood, and sorry I could not become a paid subscriber — oh no, wait you can:
“There's a drug called vioxx that was found to be safe and effective in animal trials, so they moved it on to preclinical trials in humans. Once on the market, that drug caused 88,000 people to have heart attacks and killed 38,000 people.” Meredith Blanchard We have some big news at Species Unite. In January and February, our team traveled to Bainbridge, Georgia to begin filming our first documentary. Bainbridge is a small Southern town facing a truly chilling threat: a company called Safer Human Medicine is planning to build the largest monkey breeding facility in the United States right in their backyard. If approved, this facility would hold up to 30,000 long-tailed macaques at a time—monkeys who would be bred in captivity, then sold to pharmaceutical companies for use in painful and outdated animal experiments. It's a nightmare for the animals. But it's also a nightmare for the people of Bainbridge: from threats to their water and soil, to dangerous zoonotic disease risks, to the loss of wildlife and community health. The people of Bainbridge are fighting back. And they're not alone. One of our partners on this film is the National Anti-Vivisection Society, or NAVS—an organization dedicated to ending the exploitation of animals in science. Today's guest is Meredith Blanchard, the Senior Manager of Advocacy and Policy at NAVS. I spoke with her about what's why animal testing doesn't work and what it will take to finally bring it to an end. Links: National Anti-Vivisection Society https://navs.org/
Today I answer your emails! News about mice genetically modified with a candidate for the "human speech gene!" Then we discover why baby penguins are so cute, and more! See omnystudio.com/listener for privacy information.
What if the air freshener in your car was more dangerous than the pollution outside? In this explosive episode, Darin reveals what's really inside those “harmless” little trees hanging from car mirrors—and why they could be silently damaging your health. Backed by real science and peer-reviewed studies, Darin uncovers the shocking truth about volatile organic compounds (VOCs), the health effects on the brain and lungs, and the corporations that won't label them. You'll also learn how to detox your air, reclaim your health, and even start a grassroots movement to get a fragrance-free option in ride shares like Uber and Lyft. Studies: There's this study called “Volatile Chemical Emissions from Car Air Fresheners”—and wow. Researchers analyzed 12 popular car fresheners—those trees, clips, sprays, gels—you name it. Here's what they found: 546 volatile organic compounds. That's VOCs. Out of those, 30 were considered potentially hazardous—things like formaldehyde, benzene, and other stuff you definitely don't want marinating your brain. And you know what's wild? Not a single one of those hazardous chemicals was listed on the label. (Steinemann et al., 2020) There's a study called “Fragranced Consumer Products: Effects on Asthmatics”—and it found that over 64% of people with asthma reported real symptoms from these scented products: wheezing, headaches, even full-on asthma attacks. And 41% said air fresheners were the trigger (Steinemann, 2017). Another one? “Migraine Headaches and Fragranced Consumer Products.” Nearly half of the people who get migraines said air fresheners specifically set them off (Steinemann & Nematollahi, 2020). And if you're neurodivergent—like folks with autism? This next one breaks my heart. In the study “Fragranced Consumer Products: Effects on Autistic Adults,” 83.7% of autistic individuals said fragranced products triggered serious neurological and respiratory problems—and 63% said air fresheners were one of the worst offenders (Steinemann, 2018). In a study out of Nigeria, researchers exposed mice to a solid commercial air freshener. After a few weeks, the mice showed increased anxiety, depression-like behavior, memory loss, and signs of oxidative stress in the brain. Their brains were literally under chemical assault. The study's called “Neurobehavioral Effects of Prolonged Exposure to Solid Air Freshener in Mice.” Check it out—it's eye-opening (Umukoro et al., 2019). Sorry to tell you… greenwashed products aren't any better. In the same 2020 study I mentioned earlier, researchers tested “natural” versions too—and found no meaningful difference in the chemicals they released (Steinemann et al., 2020). What You'll Learn in This Episode: 00:00 – Introduction: The truth about air fresheners 00:44 – Why Darin refuses to use ride shares with scent trees 01:50 – The hidden study on VOCs in popular car air fresheners 02:30 – 546 chemicals discovered—30 considered hazardous 03:00 – Where is the regulation? Why there are no labels 03:55 – Formaldehyde, benzene, and what they do to your body 05:00 – The link between asthma, headaches, and fragrances 05:45 – 64% of asthmatics report fragrance-triggered symptoms 06:25 – What these chemicals do to neurodivergent individuals 07:10 – Mice studies: anxiety, memory loss, oxidative stress 08:40 – Ubers, Lyfts, and chronic chemical exposure 09:15 – “Greenwashed” products are just as toxic 10:00 – No regulation, no labeling: the wild west of scent marketing 10:50 – A call to action: the Uber/Lyft fragrance-free movement 12:02 – How to tag and campaign for safer ride shares 13:00 – What you can use instead: baking soda, charcoal, and nature 14:40 – Exactly how to ask a driver to remove chemical air fresheners 15:41 – Final message: take your air—and your health—back Don't Forget... I just launched my brand new program Superlife Supermind. Visit my website https://superlife.com/ to learn more about how you can get rid of stress, improve sleep and overall health today. Connect with Darin Olien: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Key Takeaway: "Your car shouldn't smell like a fake ocean breeze—it should smell like clean, chemical-free life." – Darin Olien Bibliography: 1. Steinemann, A., et al. (2020). Volatile chemical emissions from car air fresheners. Link 2. Steinemann, A. (2017). Fragranced consumer products: effects on asthmatics. Link 3. Steinemann, A. (2018). Fragranced consumer products: effects on autistic adults. Link 4. Steinemann, A., & Nematollahi, N. (2020). Migraine headaches and fragranced consumer products. Link 5. Umukoro, S., et al. (2019). Neurobehavioral Effects of Prolonged Exposure to Solid Air Freshener in Mice. Link
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