Podcasts about Cellular

ReferencesPNAS. 2011. May 24| vol. 108 | no. 21 .E118–E127 Discov Immunol. 2024 Nov 19;3(1):kyae016Cureus. 2025 Sep26;17(9):e93294Cell Reports Medicine 2022. Volume 3, Issue 3, 15 March 100543Discov Immunol. 2024 Nov 19;3(1):kyae016.Guerra, DJ. 2026 Unpublished LecturesMcQuinn,ParsonsKelly, Hillman, Dylan, Haggard.1968.Sweetheart of the Rodeo .lp .Byrdshttps://music.youtube.com/playlist?list=OLAK5uy_kejb97oJ9VJCssjIxpz2YeHK9htTy-wz0&si=XNJafnmA_B64KHcs

ReferencesGuerra, DJ.2026. Unpublished LecturesMcClean, D. 1971 American Piehttps://open.spotify.com/track/1fDsrQ23eTAVFElUMaf38X?si=05a7bcbf872c4220

ReferencesDiscov Immunol. 2024 Nov 19;3(1):kyae016Cell Metab. 2012 Jun 6;15(6):813-26. Dev Comp Immunol . 2020 Aug:109:103694. Guerra, DJ.2026. Unpublished LecturesMozart, WA. 1791. String Quintet in E-flat major, K. 614.https://music.youtube.com/watch?v=hEFu9iV0Zxw&si=xmWnzWorPG9Xtqzy

ReferencesDiscov Immunol. 2024 Nov 19;3(1):kyae016Cell Reports2015 Volume 13, Issue 1p132-144October 06, Guerra. DJ.2026.Unpublished Lectures.Hayward/Pinder/Thomas/Edge.1969. To Our Children's Children Moody Blueshttps://music.youtube.com/playlist?list=OLAK5uy_nUbo_GZxI3GafKmIJazCD_XP1LSA5bRX4&si=sFMKnz_osf0rlmmu

ReferencesGastroenterol Res Pract. 2025 Feb 26;2025:4950214Guerra, DJ. 2026. Unpublished LecturesStaines, B.1979 The Logging Songhttps://open.spotify.com/track/23NH1l9Gn2RmAtMYt9oLfr?si=88a409a32f364989

BUFFALO, NY — July 16, 2026 — A new #research paper was #published in Volume 18 of Aging on July 1, 2026, titled “Senescent cells accumulate lipid droplets.” The study was led by first author Noa Rachmian-Cooper and corresponding author Valery Krizhanovsky from the Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. Cellular senescence is a natural biological process in which damaged or stressed cells permanently stop dividing while remaining metabolically active. Although senescence helps suppress tumor formation and supports normal processes such as tissue repair and development, senescent cells accumulate with age and contribute to chronic inflammation and numerous age-related diseases, including cancer, cardiovascular disease, and Alzheimer's disease. While many of the biological effects of senescent cells have been linked to inflammatory signaling, much less has been understood about the metabolic changes that accompany senescence. In this study, the researchers investigated how cellular metabolism changes during senescence, with a particular focus on lipid metabolism. Using comprehensive metabolic profiling of human fibroblasts, they discovered that senescent cells accumulate high levels of triacylglycerols—the major precursors of lipid droplets—alongside increased glycolytic activity. Additional laboratory experiments confirmed that senescent cells contain significantly more lipid droplets than actively dividing cells. Full press release - https://www.aging-us.com/news-room/senescent-cells-found-to-accumulate-lipid-droplets-across-aging-and-alzheimers-disease DOI - https://doi.org/10.18632/aging.206390 Corresponding author - Valery Krizhanovsky - valery.krizhanovsky@weizmann.ac.il Abstract video - https://www.youtube.com/watch?v=GZbhY3wtGGI Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206390 Keywords - aging, senescence, lipid droplets, metabolism, Alzheimer's disease To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Each month, we will highlight a paper published in Aging chosen as the “Editors' Choice.” These selections are handpicked by our editors and accompanied by a brief summary, showcasing research with significant impact and novel insights in aging and age-related diseases. Cellular senescence is a hallmark of aging and age-related disease, yet the diverse mechanisms that trigger this cellular state remain incompletely understood. The review recently published in Volume 18 of Aging, titled “The multifaceted inducers of cellular senescence,” examines the many intrinsic and extrinsic stimuli that induce senescence, including DNA damage, oxidative and mitochondrial stress, telomere attrition, oncogene activation, cell–cell fusion, and developmental signals. The authors, Hilah Gal and Valery Krizhanovsky, explain how these distinct pathways converge on a stable cell-cycle arrest. By highlighting the complexity and heterogeneity of senescent cells, the authors provide valuable insights that may guide the development of future therapies targeting senescence to promote healthy aging and combat age-related diseases. DOI - https://doi.org/10.18632/aging.206391 Corresponding author - Valery Krizhanovsky - valery.krizhanovsky@weizmann.ac.il Abstract video - https://www.youtube.com/watch?v=5Y7R_8GQ1gk Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206391 Keywords - aging, cell senescence To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

ReferencesFront Immunol. 2020 Jul 8;11:1024Neural Regen Res. 2019 Apr;14(4):595–596.Guerra, DJ. 2026. Unpublished LecturesLennon/McCartney. 1966 Good Day Sunshine. Beatleshttps://open.spotify.com/track/7HTH1ppjkkOe7RLoBDKXYJ?si=81b7d875d47a48ee

I sat down with Dr. Jordan Metzl, a sports-medicine physician who's convinced that the reason most of us can't stay consistent isn't discipline or knowledge, it's motivation, and he says you can actually engineer it by "lowering the cost to act." We get into exercise as a literal medicine that would beat almost any drug if it came in a pill, why fun is the real holy grail of compliance, and how movement can go head-to-head with antidepressants for everyday anxiety and depression. If you've been white-knuckling your way through willpower and losing, this one's going to change how you think about getting off the couch. CLICK HERE TO BECOME GARY'S VIP!: https://bit.ly/4ai0Xwg Get Dr. Jordan Metzl's book, “Push: Unlock the Science of Fitness Motivation to Embrace Health and Longevity”: https://bit.ly/4f28xiO Connect with Dr. Jordan Metzl Website: https://bit.ly/4gzA0tp  Instagram: https://bit.ly/4aRhbhA  Facebook: https://bit.ly/4fdR45E  X: https://bit.ly/4aP5Mig   Thank you to our partners A-GAME: “ULTIMATE15” FOR 15% OFF: http://bit.ly/4kek1ij AION: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4h6KHAD AIRES: "ULTIMATE20 " FOR 20% OFF: https://bit.ly/4a3Duze BAJA GOLD: "ULTIMATE10" FOR 10% OFF: https://bit.ly/3WSBqUa BODYHEALTH: “ULTIMATE20” FOR 20% OFF: http://bit.ly/4e5IjsV COLD LIFE: THE ULTIMATE HUMAN PLUNGE: https://bit.ly/4eULUKp CYMBIOTIKA: "ULTIMATE20" FOR 20% OFF: https://bit.ly/4tjyluP GENETIC METHYLATION TEST (UK ONLY): https://bit.ly/48QJJrk GENETIC TEST (USA ONLY): ⁠https://bit.ly/3Yg1Uk9 GOPUFF: GET YOUR FAVORITE SNACK!: https://bit.ly/4obIFDC H2TAB: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4hMNdgg HEALF: 10% OFF YOUR ORDER: https://bit.ly/41HJg6S PEPTUAL: “TUH10” FOR 10% OFF: https://bit.ly/4mKxgcn SNOOZE: LET'S GET TO SLEEP!: https://bit.ly/4pt1T6V WHOOP: JOIN & GET 1 FREE MONTH!: https://bit.ly/3VQ0nzW Watch  the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST: YouTube: https://bit.ly/3RPQYX8 Podcasts: https://bit.ly/3RQftU0 Connect with Gary Brecka Instagram: https://bit.ly/3RPpnFs TikTok: https://bit.ly/4coJ8fo X: https://bit.ly/3Opc8tf Facebook: https://bit.ly/464VA1H LinkedIn: https://bit.ly/4hH7Ri2 Website: https://bit.ly/4eLDbdU Merch: https://bit.ly/4aBpOM1 Newsletter: https://bit.ly/47ejrws Ask Gary: https://bit.ly/3PEAJuG Timestamps 00:00 - ​Intro of Show 02:00 - From family of doctors to sports medicine 04:00 - Prescribing the medicine of exercise 05:55 - What an exercise prescription looks like 07:41 - The 1950s London Transport study 10:22 - Cellular adaptations and mitochondria 11:52 - Inflammation and chronic disease 13:31 - Immuno-fatigue and the theory of aging 14:45 - Motivation, not discipline, is missing 18:14 - Knowledge, emotion, and belief 20:25 - Building a fitness community 24:11 - Biomarkers and the cost of chronic disease 26:23 - Lifespan vs healthspan gap 28:26 - Fun is the holy grail of compliance 34:00 - Why remote work hurts our health 39:16 - Making exercise pay for doctors 41:01 - Two minutes of vigorous activity a day 44:30 - The GLP-1 and arthritic knee study 48:49 - Exercise vs antidepressants 55:38 - Lowering the cost to act 59:42 - What it means to be an Ultimate Human 1:01:29 - Alice: a marathon at 70 Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions.  Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation.  Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered promotional in nature. Learn more about your ad choices. Visit megaphone.fm/adchoices

Fill Me In: An Aesthetics Podcast | Episode 56Welcome back to Fill Me In: An Aesthetics Podcast! In this special live episode recorded on-site at Modern Beauty Con, hosts Jon LeSuer and Nicole Bauer sit down with master injector, Allergan trainer, and functional medicine pioneer Jenna Hilton, PA-C.As the medical aesthetics industry shifts rapidly toward cellular biology and systemic wellness, Jenna drops massive insights on how to achieve superior dermal filler and neuromodulator outcomes by starting from the inside out. If you are an injector looking to scale your practice, set yourself apart in a saturated market, or blend longevity medicine with aesthetic treatments, this episode is your blueprint.✨ In this episode, we dive into:How hormone replacement therapy (HRT) and gut health directly impact skin healing and anti-aging results.The physical signs of cellular inflammation Jenna looks for during a patient assessment (including teeth, bite, and red gums).Why she will intentionally withhold filler treatments from patients with high alcohol intake or poor lifestyle factors.Essential business advice for year-two injectors looking to discover their niche and build unbreakable patient trust.Practical strategies for implementing functional wellness and hormone evaluation into a 30-minute aesthetic consultation.

ReferencesFront Immunol. 2025 Dec 3;16:1712452.Nat Commun. 2024 Nov 12;15:9803. Guerra, DJ.2026.Unpublished LecturesMiller, S. 1970. Steven Miller Band Vhttps://music.youtube.com/playlist?list=OLAK5uy_mMurbyyiMLz7bvTAJmI_j8sCs_e-NbvAM&si=0i95A7H0jAkW7AU2

In this conversation, Ari Whitten and I go straight to the cellular level to answer a question most of cardiology never asks: where does your energy actually come from, and what happens to your heart when it runs low? Ari walks through the work of Dr. Robert Naviaux and the ‘cell danger response,' the idea that your mitochondria are constantly reading the environment and deciding whether to make energy or switch into defense mode. Stressors like toxins, junk food, poor sleep, and chronic psychological stress push them toward defense, and that shift shows up as fatigue, oxidative stress, and inflammation, the same drivers I see underneath so much heart disease.From there, we get practical. Ari breaks down why how you breathe matters as much as how much you move, how a simple breath-hold test reflects your body's oxygen delivery, and why 20 to 30 minutes of daily movement may be one of the most powerful things you can do for your heart. It all comes back to what I teach every day: Eat Well, Live Well, Think Well. Give your cells what they were designed for, and your energy and your heart tend to follow.- - - - -About the Guest:Ari Whitten, MS, is the founder of The Energy Blueprint and one of the most respected evidence-based voices on fatigue, energy, and mitochondrial health. He holds a Master of Science in Human Nutrition and Functional Medicine, a bachelor's in Kinesiology, and certifications from the National Academy of Sports Medicine as a Corrective Exercise Specialist and Performance Enhancement Specialist.After losing nearly a year of his own life to severe chronic fatigue in his twenties, Ari devoted his career to understanding how cellular energy is built and broken. He is the bestselling author of Eat for Energy and The Ultimate Guide to Red Light Therapy, and has taught his science-first approach to energy on stages around the world.Website: theenergyblueprint.comInstagram: @theenergyblueprintPodcast: The Energy Blueprint- - - - -Jack Wolfson, DO, FACCWebsites: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drjackwolfson.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠; ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://naturalheartdoctor.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠LinkedIn: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.linkedin.com/in/drjackwolfson⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Ready to move past the confusion and fear of typical heart health approaches? Visit ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠naturalheartdoctor.com/discovery⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ to schedule your free discovery call and start your journey toward a 100-year heart with real, evidence-based answers.- - - - -PODCAST Thank you for listening. Please subscribe and share. This podcast is produced by DrTalks.com ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drtalks.com/podcast-service/

ReferencesNature Communications2=18. Vol. 9,Article number: 1228 PLoS One. 2024 Jul 5;19(7):e0304997Guerra, 2026 Unpublished LecturesSquire et al. 1971. Yes. Heart of the Sunrise Yessopngshttps://open.spotify.com/track/3vwjrVDFKelpfuD6yO1oW4?si=821bc04addaf46dd

Welcome to The New World — it's everything the 2026 shift has been preparing you for. Now it's time to reset your central nervous system so you can enjoy the higher state of consciousness and create the life you want. Two weeks ago the molecular structure of the universe itself shifted. And everything you are experiencing right now — the exhaustion, the chaos, the parts of your life that feel impossible alongside the parts that feel more alive than ever — it's your initiation to the new world. EP223 is a special edition of The Story of Creation where The Creator and Universal Beings explain your arrival in the new world then give you the opportunity to experience Cellular Energy Healing — how you were always meant to — through direct connection with the Universal Beings who created you. Why? To prepare you for the greatest shift in human consciousness ever. And to remind you that you really are self healing and the entire universe is working with you to restore you to who you were created to be. By the end of this episode you will understand what actually happened two weeks ago — the molecular shift in the universe that explains everything you have been feeling. You will know why the chaos in some areas of your life is not failure but evidence of exactly how far you have come. You will understand why your central nervous system is overwhelmed right now and why it is not a malfunction but the most accurate signal your body has ever sent you. You will experience the cellular energy healing ceremony that realigns your central nervous system to your original soul design — giving you the energy you need to keep going. And you will know why you can come back to this ceremony as many times as you need — each time your system receives exactly what it needs for where you are right now. This episode takes you from spiritual exhaustion to sustainable spiritual growth designed specifically for the 2026 shift. Your nervous system has been waiting for it. For cellular energy healing guidance: michellevickers.com/cellular-regeneration Join The Authentic Human Collective for a front row seat: michellevickers.com/community The Authentic Human Podcast | Special Edition | The Story of Creation 0:00 Universal update — the molecular shift in the universe that explains everything you're feeling 3:48 Why some areas of your life are in complete flow and others have stopped — what you need to know about where you are 5:21 Fifty thousand years of conditioning meeting its match — what the resurrection of humanity actually looks like right now 13:17 What the last 80 years of preparation were actually for — and why it all led to right now 20:46 Why the chaos in your life right now isn't failure — it's a powerful gift from the universe itself 21:47 Why your central nervous system is overwhelmed — what is actually happening and why it makes complete sense 30:36 How the new world is being built right now in real time — how you're meant to help 37:36 The cellular energy healing ceremony begins — realigning your central nervous system to your original soul design 41:09 What the ceremony is actually doing — bringing your central nervous system into alignment with your original soul intention for this life 44:15 Why sacred ceremony is native to human existence — and why every belief system in history had it at its core

Have you ever wondered what happens to your body at a cellular level as you age? In this episode, we explore the science behind NanoVi Technology and how it supports your body's natural ability to repair damage caused by oxidative stress. Rowena Gates, VP of Eng3 Corporation, joins us to discuss how bioenergetic signals can influence protein function, improve recovery, and boost cognitive performance. Discover how this fascinating technology is reshaping the future of health, longevity, and biological regeneration. Learn why protein activity is the key to maintaining a healthy life and how you can support your body's innate healing wisdom.The information presented in Fully Alive is for educational and informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or treatment and before making changes to your health regimen. Guests' opinions are their own and do not necessarily reflect those of the podcast host, production team, or sponsors.Love the show? Subscribe, rate, review, & share! https://www.shellpoint.org/podcast/

ReferencesJCI Insight. 2018 Sep 6;3(17):e121630Signal Transduction and Targeted Therapy2022.. 7, : 304 Arthritis Res Ther.2021; 23: 19.MDPI Genes 2021, 12(9), 1313; https://doi.org/10.3390/genes12091313Guerra, DJ.2026. Unpublished LecturesLennon/McCartney. 1965. Wait Rubber Soul Beatleshttps://music.youtube.com/watch?v=qJngWval8Bc&si=9ZTkMl5YuJ870EJ4Lennon/McCartney.1968. Long Long Long White Album. Beatles.https://music.youtube.com/watch?v=e9vUCdfwlgw&si=p-8M8n6bgUurCuq8

392: In this episode, I'm joined by Karalynne Call, founder of Just Ingredients, to discuss why blood sugar balance is one of the most important foundations of children's health. We break down how protein, healthy fats, fiber, and carbohydrates affect kids' energy, mood, focus, hunger, and long-term metabolic health. We also discuss simple ways to build balanced meals and snacks, why sugar and processed foods can lead to blood sugar spikes and crashes, and practical strategies to help your kids develop healthy eating habits without restriction or perfection. Whether you're packing school lunches, navigating picky eating, or simply looking to support your family's health, this episode is full of practical tips you can start using today. → Leave Us A Voice Message!  Topics Discussed: → Blood Sugar Balance for Kids → Protein, Healthy Fats & Fiber → Children's Mood, Focus & Behavior → Healthy Snacks & Hunger Hormones → Sugar, Processed Foods & Metabolic Health → Practical Nutrition for Busy Families → The Fab Four Method → Raising Healthy Eaters Without Restriction → Meal Prep & Simple Family Nutrition → Building Lifelong Healthy Habits Sponsored By:  → Be Well By Kelly Protein Powder & Essentials | Get $10 off your order with PODCAST10 at https://bewellbykelly.com. Timestamps:  → 00:00:00 - Introduction → 00:01:30 - Meet Karalynne Call → 00:02:38 - Why blood sugar matters for kids → 00:05:45 - Protein, healthy fats & carbohydrates explained → 00:08:20 - Cellular vs. acellular carbohydrates → 00:11:15 - Why sugar causes blood sugar spikes & crashes → 00:15:54 - Why balanced blood sugar matters for children → 00:19:05 - How nutrition affects kids' mood, focus & behavior → 00:22:40 - Building balanced meals for kids → 00:25:35 - Healthy snacks that actually keep kids full → 00:29:05 - Hunger hormones & constant snacking → 00:32:45 - Practical lunchbox & snack ideas → 00:35:45 - Setting healthy food boundaries without restriction → 00:39:00 - Sugary drinks & childhood metabolic health → 00:42:35 - Preventing Type 2 diabetes through nutrition → 00:46:15 - Simple nutrition habits for busy families → 00:49:35 - Why family meals matter → 00:52:20 - Raising confident, healthy eaters → 00:55:10 - Where to find Karalynne Call & Just Ingredients Further Listening:  → https://youtu.be/1NaXfS-1q3I?si=LukJStTiDsf3QhKR Check Out Karalynne Call → https://www.instagram.com/just.ingredients → https://justingredients.com/pages/just-ingredients-podcast Check Out Kelly: → Instagram → Youtube → Facebook

In this episode of the Health Optimization Medicine Podcast, our faculty, Dr. Scott Sherr, Dr. Ted Achacoso, Boomer Anderson, Dr. Allen Bookatz, and Jodi Duval, tackle the recent trend of therapeutic plasma exchange and "blood washing". Moving past the mainstream marketing of plasmapheresis as a longevity cure-all, the team breaks down why mechanical filtering is only a surface-level fix for microplastic toxicity. From the autonomic anxiety caused by biological lockdown to the clinical application of precision metabolomics, this roundtable shifts the conversation from invasive procedures to measurable, cellular safety signals.   Join us as we delve into: The Protein Corona: How circulating microplastics masquerade as pathogens, triggering localized purinergic signaling and the release of extracellular ATP. The Cell Danger Response (CDR1): Why the body halts oxidative phosphorylation and locks down the cell membrane when invaded, and why blood washing can't touch toxins stuck inside tissue matrices. The Problem with Plasmapheresis: The clinical realities and physiological costs of invasive vascular filtering, including the removal of essential immunoglobulins and clotting factors. The True Detox Protocol: Utilizing organic carbon binders (humic and fulvic acids), phase two liver conjugation (glucuronidation/sulfation), and barrier integrity support to properly excrete microplastics. Pulsed Antioxidant Support: When and why to use targeted NAD, alpha-lipoic acid, NAC, and ubiquinol to transition cells out of a defensive lockdown.   This episode is for you if: You are considering expensive therapies like plasmapheresis to clear environmental toxins. You want to learn how to test your cellular metabolomics for organic acids and brain inflammation. You want to understand how your unique exposome interacts with your cellular safety mechanisms.   You can also find this episode on… YouTube: https://youtu.be/5b4jWqByRAU   Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ HOMeHOPe Conference 2026: https://homehope.org/homehope-conference-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics   Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products  

References Nat Struct Mol Biol . 2006 Dec;13(12):1097-101Open Biol. 2013 Oct;3(10):130144Arthritis Res Ther.2021; 23: 19.European Review for Medical and Pharmacological Sciences 2021; 25: 1425-1435Frontiers in Immunology 2024 09 January DOI 10.3389/fimmu.2023.132280Guerra, DJ. 2026.Unpublished Lectures.Teleman, G P 1716. Concerto in D. TWV51 https://music.youtube.com/watch?v=F5J80v3ACbo&si=oiJxKkpbnLhiZ833Hunter/Garcia.1973. Stella Blue. Grateful Dead.https://music.youtube.com/watch?v=VKsWDyvWaL4&si=Jul71w1djWl2WTIIp. 1716. D1 TWV51.

Have you ever wondered why some people seem to do everything "right"—eat nutritious foods, take quality supplements, exercise regularly, and prioritize sleep—yet still struggle with fatigue, inflammation, hormone imbalance, or stubborn metabolic issues? In this fascinating conversation, I sit down with Dan Stachofsky, founder of Essential Energy, to explore one of the most overlooked influences on our health: the environment we live in every day. Dan's journey into environmental health began after his daughter developed a chronic immune condition that didn't fully respond to conventional or functional medicine. His search for answers led him to investigate how light, electromagnetic fields (EMFs), and our modern environment influence cellular energy, nervous system regulation, and the body's ability to heal. If you've been working to improve your metabolism, reverse insulin resistance, heal adrenal dysfunction, or restore your energy but still feel stuck, this episode may help you discover a missing piece of the puzzle. WHAT WE DISCUSSED: Dan's personal journey from technology executive to environmental health advocate Why some people don't heal—even when they're following the "perfect" protocol The hidden impact of our modern environment on metabolism and overall health How light influences mitochondria, cellular energy, and recovery The relationship between EMFs, the nervous system, and chronic stress Why circadian health is foundational for hormone balance and healing How artificial light can affect sleep, cortisol, melatonin, and blood sugar regulation Practical ways to create a healthier home and work environment Simple changes you can make today to better support your body's natural healing processes ABOUT DAN STACHOFSKY Dan Stachofsky is the founder of Essential Energy. After years in the technology industry helping build digital infrastructure for companies like Microsoft and Amazon, his daughter's chronic illness led him on a search for answers beyond conventional medicine. Today, Dan works alongside integrative practitioners to help people understand how light, electromagnetic fields, and environmental stress can impact cellular function and long-term health. Learn more at: https://essentialenergy.solutions/ Use code SHANAH for a discount! READY TO RESET YOUR HEALTH? If you're realizing there's more to healing than just food and supplements, my COMPASS 90-Day Metabolic Reset Program is the perfect place to begin. COMPASS is a simple, step-by-step program designed to help you reduce inflammation, stabilize blood sugar, improve energy, reverse fatty liver, reduce sholesterol, and build a strong foundation for metabolic health. You'll learn practical strategies around nutrition, meal timing, circadian rhythm, light exposure, stress reduction, and other lifestyle habits that help your body function the way it was designed to. Learn more here: https://shanahussinwellness.com/programs-courses/reset/ LET'S CONNECT Website: https://shanahussinwellness.com Instagram: @shana.hussin.rdn Facebook: Shana Hussin Wellness

ReferencesFrontiers in Immunology 2014. November 21(578):1Clin Epigenetics. 2017; 9: 94. Cancer Cell International 2020. September 20(1):429Guerra, DJ.2026. Unpublished Lectures.Vinsom/Chapman/Burnett. 1930. Sitting On Top of the World Creamhttps://open.spotify.com/track/0aY5bJ4jRHiOd8eCMWmcy8?si=b3c7f2090c6e441cJagger/Richards.1965.Satisfaction Rolling Stoneshttps://open.spotify.com/track/2PzU4IB8Dr6mxV3lHuaG34?si=6b244c676bf1454eLennon/McCartney. 1968 Helter Skelterhttps://open.spotify.com/track/0Bs0hUYxz7REyIHH7tRhL2?si=f345fea1161a4f27Paige/ Plant 1971. Rock and Roll Led Zepplinhttps://open.spotify.com/track/4PRGxHpCpF2yoOHYKQIEwD?si=3203893185c24bee

BUFFALO, NY — July 7, 2026 — A new #review was #published in Volume 18 of Aging on June 22, 2026, titled “The multifaceted inducers of cellular senescence.” The review was led by first author Hilah Gal and corresponding author Valery Krizhanovsky from the Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. Cellular senescence is a fundamental biological process in which damaged or stressed cells permanently stop dividing while remaining metabolically active. This response plays an essential role in suppressing tumor formation, supporting embryonic development, facilitating wound healing, and maintaining tissue integrity. However, as people age, senescent cells accumulate because they are no longer efficiently cleared by the immune system. Their persistence contributes to chronic inflammation, tissue dysfunction, cancer, and many age-related diseases. In this comprehensive review, the authors examine the diverse biological stimuli that trigger cellular senescence and describe how seemingly different stimuli ultimately converge on common molecular pathways that establish stable growth arrest. Rather than viewing senescence as a single process, the review emphasizes its remarkable biological diversity and the importance of understanding how different initiating events shape distinct senescent cell phenotypes. The review discusses several major biological inducers of cellular senescence. One of the best-established mechanisms is telomere attrition, in which repeated cell division gradually shortens chromosome ends until they trigger a persistent DNA damage response. Other important stimuli include direct DNA damage caused by ionizing radiation, ultraviolet light, chemotherapy, and oxidative injury, all of which activate cellular pathways that permanently halt proliferation. Full press release - https://aging-us.net/2026/07/07/multiple-biological-triggers-shape-cellular-senescence-in-aging-and-disease/ DOI - https://doi.org/10.18632/aging.206391 Corresponding author - Valery Krizhanovsky - valery.krizhanovsky@weizmann.ac.il Abstract video - https://www.youtube.com/watch?v=5Y7R_8GQ1gk Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206391 Keywords - aging, cell senescence To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

ReferencesAtherosclerosis .2012 Mar;221(1):2-11.Antiox and Redox Sig. 2018. March 30(6):813-856Experimental Immunol. 2018.v87. issue 4:e12648Scand J Immunol. 2018 Apr;87(4):e12648Front. Immunol. Sec. Cancer Immunity and Immunotherapy 2025. vol16 05 February Guerra,DJ.2026.Unpublished Lectures.Dvorak. A. 1894. American Suite in A Major. op.98https://music.youtube.com/watch?v=yi37I6w46FM&si=hhBZx2_TqEu9Txmn

References Sci Signal. 2017 Jul 25;10(489)EMBO Rep. 2017 Mar 7;18(4):645-657`Guerra, DJ. 2026. Unpublished LecturesHunter/Garcia, et al.1970. American Beauty lp. Grateful Dead.https://music.youtube.com/playlist?list=OLAK5uy_nc3dHmM6xdsySO1SSxYLYzlm82rVZ1pfM&si=2xOrRK6QpYFeI8Is

ReferencesBiochimica et Biophysica Acta (BBA) 2026 - Molecular Basis of Disease February168069 Volume 1872, Issue 2Comput Math Methods Med. 2012 Sep 16; 2012:173521Front. Immunol.2026. 15 April Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune DisordersVolume 17 - 202Guerra, DJ. 2026. Unpublished LecturesHunter/Garcia.1973. US Blues Grateful Deadhttps://music.youtube.com/watch?v=-IBk5xk5Pec&si=yMHTzyV2p8xsIZly

Have you ever found yourself thinking, "I just don't feel like myself anymore?"In Episode 5 of the Healing Forward Wellness Spotlight Series, Barbara La Pointe and Kevin J. David explore the changes many women experience after 40—from fluctuating energy and increased stress to hormonal shifts, recovery challenges, and the demands of modern life.This honest conversation looks at why so many women feel depleted, overwhelmed, or disconnected from the vibrant version of themselves they once knew, and why understanding the bigger picture of wellness matters.In this episode, we discuss:• Hormonal changes and midlife wellness• Why energy feels different after 40• The impact of chronic stress on the body• Recovery, resilience, and healthy aging• Emotional load, caregiving, and modern life• The importance of supporting wellness at the foundational level• Cellular wellness and proactive health choicesIf you've ever wondered whether it's stress, hormones, aging—or a combination of all three—this episode is for you.If you'd like to learn more about the glutathione wellness solution discussed throughout this series, or you're curious about supporting your energy, resilience, and overall wellness, reach out to Barbara La Pointe for more information.Whats App in Mexico: 52-322-101-8268Email: Barbaralapointe@gmail.com or barbaralapointecoaching@gmail.comHealing Forward with Barbara La Pointe#HealingForward #KevinJDavid #BarbaraLaPointe #WomenOver40 #Hormones #MidlifeWellness #HealthyAging #EnergyAfter40 #WomensHealth #WellnessPodcastSupport the show

ReferencesNeuroendocrinology. 2000 Mar;71(3):187-95J Immunol.2014 Jan 3;192(3):979–984.Molecular and Cellular Endocrinology 2018.Volume 472, 5 September: 40-49Front. Immunol., 2023. 16 March Sec. T Cell Biology.Volume 14 -Guerra, DJ. 2026. Unpublished Lectures.Emerson/Lake/Palmer. 1972. Trilogy lp. fullhttps://music.youtube.com/playlist?list=OLAK5uy_m-KrYKLiBdrOau11bsTte7M4qSR0en7VI&si=DwpdwN0nR_IGNsK1

What if one of the biggest missing links to energy, recovery, healthy aging, and longevity is your body's master antioxidant—glutathione? In this episode, I sit down with Dr. Nayan Patel, pharmacist, researcher, author, and founder of Auro Wellness, to explore the science behind glutathione, oxidative stress, detoxification, mitochondrial health, and why absorption matters. We discuss: Why glutathione declines with age and chronic stress The connection between oxidative stress, inflammation, and recovery How glutathione supports mitochondria, immunity, and cellular resilience Practical strategies to optimize your body's antioxidant defenses If you're a high performer or aging athlete who wants to improve healthspan, recovery, and performance from the inside out, this episode is for you. Connect with Dr. Nayan Patel Website: https://aurowellness.com Book: The Glutathione Revolution Instagram: https://www.instagram.com/aurowellness YouTube: https://www.youtube.com/@AuroWellness Learn more about Debbie Potts at www.debbiepotts.net

This episode, we're stepping back to the golden age of natural history podcasting by resurrecting the format of the classic show Wild Ideas: The Podcast. Joining us on the trail is one of the OG hosts: the man himself, Gordon Maupin. It's a 3-way team-up where each of us brings a heavy-hitting seasonal mystery to the table.First, Steve unravels the rule-breaking world of the Ambystoma polyploid salamander complex, where unisexual lineages are mixing up DNA from different species and blurring the lines of what makes a species a species. Then, Gordon shrinks things down to look at the world of duckweed ecology, a group that includes the smallest flowering plants in the world. Finally, Bill turns our eyes to the skies over the marsh to pull back the curtain on dragonfly migration, looking into the recent science that shows some dragonfly species are multi-generational continental travelers (as well as badass predators).Come listen in as Gordon and the guys answer the question, “What's going on outside?” (Wild Ideas fans, that's for you)This episode was reecorded at the Iroquois National Wildlife Refuge in Alabama, NY on May 13, 2026.Episode LinksCheck out the Iroquois National Wildlife Refige and their Bald Eagle Cam.Here's the New York Times article about 7 Podcasts About the Joys of Bird Watching that includes a mention of our show.Episode NotesGetting The Great Egret's Latin Name RightDuring a quick aside this episode, Gordon spotted a Great Egret and Steve tried to recall its scientific name, tentatively going with Erodea alba. He wasn't entirely wrong! The correct name is Ardea alba.While alba means "white," Ardea is Latin for "heron." It also ties back to the ancient myth by everyone's favorite Roman poet Ovid, who wrote about a bird rising directly from the ashes of the burned city of Ardea. What's the Deal With Axolotls?We wondered if the axolotl is in the same genus as the Jefferson and blue spotted salamander (Ambystoma) and yes they are!Species: A. mexicanum (Axolotl) Unlike most members of Ambystomatidae—which typically metamorphose into terrestrial adults—the axolotl exhibits a trait called neoteny (or paedomorphosis). This is where an organism retains juvenile or larval traits into adulthood. Axolotls retains its aquatic, larval features (like its signature feathery external gills) into adulthood and spends its entire life in the water Bill's Hard Claim on ID'ing Jefferson Salamanders Bill said there is no way we could tell if it was a Jefferson salamander: is that true? Bill was basically right if we're talking about visually confirming a female-looking salamander in a blue-spotted/Jefferson overlap zone. Many unisexual individuals cannot be confidently identified by sight, and genetic testing is the clean answer. But during the breeding season, a male with a swollen cloaca is not part of the all-female unisexual lineage, so that can help narrow things down. So, a male in breeding condition can sometimes be identified much more confidently than a female/unisexual-looking animal, but you need to have serious knowledge about species location, morphology, and breeding-season characteristics. The Jefferson Complex vs. the Bigger Unisexual Salamander SituationDuring the episode, Bill had a “wait, what are we even talking about?” moment while Steve was explaining the huge all-female/unisexual Ambystoma salamander lineage.Steve was talking about the big-picture version: a bizarre evolutionary group that can involve genomes from several mole salamander species, including Blue-spotted, Jefferson, Small-mouthed, Streamside, and Tiger Salamanders.Bill, though, was thinking what we hear more about in the Northeast and Great Lakes region: the “Jefferson complex,” or the Blue-spotted/Jefferson Salamander mess. Around here, that usually means you can't usually ID a Jefferson Salamanders or a Blue-spotted Salamander down to species because the sally in front of you may belong to the all-female, polyploid lineage that can't be confidently sorted out just by looking at them.So Bill's question was basically: “Hold on. Is this identification nightmare only a Jefferson/Blue-spotted thing, or does it happen with the other species too?”And the answer is: yep. It can happen with the others too.The narrower Jefferson complex usually refers to the Blue-spotted/Jefferson part of the story, especially in places where those are the main overlapping species. But when scientists zoom out and include the other players (Small-mouthed, Streamside, and Eastern Tiger Salamanders) they usually refer to the whole thing as the unisexual Ambystoma lineage.So the practical field takeaway is this: in places where these species overlap, a female-looking Ambystoma salamander may be impossible to identify with confidence by appearance alone. Even experts may only be making an educated guess unless they use genetic testing. Measuring red blood cell size can help estimate ploidy (basically, whether the animal has extra chromosome sets) but DNA testing is the real way to know which genomes are actually in there. Is Duckweed the Smallest Flowering Plant? Yes, but specifically a microscopic type of it. The world's smallest flowering plants belong to the genus Wolffia - Often referred to as "rootless duckweed" or "watermeal," they are the tiniest members of the duckweed family (Lemnaceae) Individual Wolffia plants are usually less than 1 mm long, roughly the size of a pinhead or cornmeal, and the flowers are correspondingly microscopic.Unlike standard duckweed (Lemna), Wolffia plants do not have roots and appear simply as tiny floating green spheres or oval seeds.The plant produces the world's smallest flower, which forms in a tiny depression on the plant's top surface.Because they are so small and have highly efficient asexual budding, they can easily cover a pond in dense mats before you ever notice an individual plant. Can be found across temperate and tropical regions of North, Central, and South America Correction: Ed Yong's An Immense World (UV, not Infrared)During the episode, Bill mentioned Ed Yong's phenomenal book, An Immense World, and noted that researchers are increasingly discovering how many animals can see in the infrared spectrum. His memory slipped slightly on this one! Yong actually discusses the growing scientific realization that many animals see in the ultraviolet (UV) spectrum, not infrared. (Though as you'll see below, dragonflies do have a few tricks up their sleeves on the other end of the spectrum). Gordon's Question: Infrared Vision & Dragonfly MatingBill's misremembering of what was in An Immense World was prompted by Gordon asking a fantastic question during the recording: Can dragonflies see in the infrared spectrum, and if they can, are they using it to navigate during migration?First, a quick clarification: when most of us hear “infrared,” we immediately picture thermal imaging — animals glowing in the dark, Predator vision, that whole thing. That is not what we're talking about here. Dragonflies do not appear to see heat signatures.What they may be able to see is near-infrared — light just beyond the deepest red wavelengths visible to humans. Near-infrared is not heat vision. It is more like an invisible extension of red.According to a recent study published in January 2026 by researchers in Osaka, Japan, some dragonfly species have visual pigments that are sensitive to extremely long red wavelengths, possibly reaching into the near-infrared edge of the spectrum. That alone is pretty wild. But the discovery also highlights a striking example of parallel evolution between insects and primates. Millions of years ago, the ancestors of humans and other primates evolved molecular changes that helped produce red-sensitive vision. This new research suggests that some dragonflies may have independently evolved a similar molecular tuning mechanism for detecting red light. However, while primate red vision operates within the visible spectrum, some dragonflies appear to have pushed that sensitivity even farther, toward the boundary between deep red and near-infrared.So what are they doing with this ability? Probably not navigating migration, at least as far as we know.The better-supported idea is that this long-wavelength vision helps dragonflies identify mates quickly in flight. Male and female dragonflies can reflect red and near-infrared light differently, especially against green vegetation. So for an animal making split-second decisions while zipping around at high speed, that extra visual contrast could be a big deal. So to answer Gordon's question, dragonflies may be seeing farther into the red/near-infrared edge of the spectrum than we can, but based on what researchers currently know, they're probably using that ability for rapid sex recognition, not long-distance navigation. It's more of a high-speed dragonfly dating filter than infrared GPS.The Missing Piece: Visual Cues and "Leading Lines" in MigrationOne big element Bill neglected to mention in covering how dragonfies navigate during migration is the VISUAL piece – that they also use what they're seeing! That is a crucial piece of the puzzle. Dragonflies are also extremely visual animals. Those huge compound eyes are not just for decoration. So, what they're seeing is likely a key piece in their migration toolbox. Migrating dragonflies are often observed moving along major landscape features: coastlines, mountain ridges, river valleys, and other long, continuous edges. Biologists sometimes refer to these kinds of features as leading lines, because they can help guide or funnel migrating animals across the landscape.That doesn't mean a dragonfly is looking down and thinking, “Ah yes, the Susquehanna River. I'll take this south.” But these landscape features can still matter in several ways.Coastlines can keep migrants from drifting too far over open water, which is risky for an insect that eventually needs to land, rest, and feed.Mountain ridges and long hillsides can create useful air currents and updrafts, allowing dragonflies to ride favorable winds and conserve energy.River corridors can provide both a visual pathway and good stopover habitat, with water, vegetation, and plenty of small flying insects to eat when they need to refuel.The overall migration story for dragonflies probably isn't “dragonflies have one magic compass.” It's more like they are combining a bunch of cues at once: the visual structure of the landscape below them, as well as the elements covered during the episode. Steve's Questions: Resident vs. Migratory Green Darners & The Thermal Genetic SwitchDuring the episode, Steve asked two really good questions about Common Green Darners: if some are migratory and some are resident, how do they know which group to mate with? And could temperature be the thing that nudges a young darner down one path or the other?The first answer is surprisingly simple: they probably don't know, and they probably don't care.For a long time, researchers assumed these groups were reproductively isolated, believing residents emerged and died before the migratory cohort reached adulthood, but modern research has overturned this idea. According to a comprehensive review by Michael L. May and John H. Matthews, adult flight periods absolutely overlap in mid-summer, and genetic testing reveals zero genetic differentiation between the groups. The entire continental population belongs to a single, randomly mating gene pool. So when a Common Green Darner is ready to mate, it is probably not checking whether the other darner is from the “resident” or “migratory” team. It is just mating with another mature Common Green Darner in the same airspace. Very romantic. Very dragonfly.Steve's second question gets at something even more interesting: what makes one generation migrate while another stays put?This is where temperature, day length, and seasonal timing seem to matter a lot. A Green Darner nymph developing in warm water during long summer days may be pushed toward faster development. That can produce adults that emerge, feed heavily, build up energy reserves, and migrate south in late summer or fall.But if nymphs are developing as temperatures drop and days get shorter, their development can slow down. Instead of rushing to become adults, they may overwinter as aquatic nymphs and emerge the following year. Those individuals can then become part of the resident breeding population in northern ponds.So Steve's instinct was basically right: environmental conditions appear to play a huge role in shaping whether a darner develops quickly and migrates, or slows down and overwinters.The only thing to be careful about is the phrase “genetic switch.” There probably are changes in gene expression involved. Temperature and day length can absolutely affect how insects develop, but in Common Green Darners, we should probably think of it less as a single switch being flipped and more as a whole developmental pathway being shaped by the environment.The short version: migratory and resident Green Darners are not separate species or rival dragonfly factions. They appear to be part of one big, mixed population whose life cycle can play out in different ways depending on timing, temperature, and local conditions.Sponsors and Ways to Support UsThank you to Always Wandering Art (Website and Etsy Shop) for providing the artwork for many of our episodes.Support us on Patreon.Works CitedHallworth, M. T., Marra, P. P., McFarland, K. P., Zahendra, S., & Studds, C. E. (2018). Tracking dragons: stable isotopes reveal the annual cycle of a long-distance migratory insect. Biology Letters, 14(12), 20180741. doi: 10.1098/rsbl.2018.0741.Hu, G., Lim, K. S., Horvitz, N., Clark, S. J., Reynolds, D. R., Sapir, N., & Chapman, J. W. (2016). Mass seasonal bioflows of high-flying insect migrants. Science, 354(6319), 1584–1587. doi: 10.1126/science.aah4379.Knight, S. M., Pitman, G. M., Flockhart, D. T. T., & Norris, D. R. (2019). Radio-tracking reveals how wind and temperature influence the pace of daytime insect migration. Biology Letters, 15(6), 20190327. doi: 10.1098/rsbl.2019.0327.Lancaster, L. T., Dudaniec, R. Y., Chauhan, P., Wellenreuther, M., Svensson, E. I., & Hansson, B. (2016). Gene expression under thermal stress varies across a geographic range expansion front. Molecular Ecology, 25(5), 1141–1156. doi: 10.1111/mec.13548.May, M. L. (2013). A critical overview of progress in studies of migration of dragonflies (Odonata: Anisoptera), with emphasis on North America. Journal of Insect Conservation, 17(1), 1–15.May, M. L., & Matthews, J. H. (2008). Migration in Odonata: a case study of Anax junius. In A. Córdoba-Aguilar (Ed.), Dragonflies and Damselflies: Model Organisms for Ecological and Evolutionary Research (pp. 63–77). Oxford University Press.Sato, R., Terakita, A., & Koyanagi, M. (2026). Dragonfly red opsins share a common tuning mechanism with mammalian red opsins and further enhancement of near-infrared sensitivity. Cellular and Molecular Life Sciences.Trottier, R. (1971). Effect of Temperature on the Life-Cycle of Anax junius (Odonata: Aeshnidae) in Canada. The Canadian Entomologist, 103(12), 1671–1683.Wikelski, M., Moskowitz, D., Adelman, J. S., Cochran, J., Wilcove, D. S., & May, M. L. (2006). Simple rules guide dragonfly migration. Biology Letters, 2(3), 325–329.Yong, E. (2022). An Immense World: How Animal Senses Reveal the Hidden Realms Around Us. Random House.

BUFFALO, NY — June 29, 2026 — A new #review was #published in Volume 18 of Aging on May 30, 2026, titled “The love and hate relationship between cellular senescence and stemness.” The review was led by first author Angelos Papaspyropoulos and corresponding author Vassilis G. Gorgoulis from the National and Kapodistrian University of Athens and the Biomedical Research Foundation of the Academy of Athens, Greece. Cellular senescence and stemness have traditionally been viewed as biological opposites. Senescent cells permanently stop dividing in response to cellular stress, helping prevent the spread of damaged cells, while stem cells maintain tissue repair by continuously renewing themselves and generating specialized cells. However, growing evidence suggests that the relationship between these two biological processes is far more complex and depends on the tissue type, physiological conditions, and disease context. In this review, the authors summarize recent research examining how senescence and stemness interact across normal tissues, aging, regeneration, and cancer. Rather than always opposing one another, the two processes can either suppress or reinforce each other depending on the biological setting. Under normal physiological conditions, senescence often limits stem cell activity. The review highlights studies showing that excessive senescence can impair the regenerative capacity of mesenchymal stem cells, muscle satellite cells, dental pulp stem cells, and pancreatic β-cell progenitors. In several experimental models, reducing senescence restored stem cell function and improved tissue regeneration. At the molecular level, multiple signaling pathways contribute to this balance, including the p53/p21 and p16INK4A/RB pathways, mTOR signaling, Wnt/β-catenin signaling, and the senescence-associated secretory phenotype (SASP). These pathways help determine whether cells maintain regenerative potential or enter a stable senescent state. The review also emphasizes that the relationship changes dramatically in cancer. In many tumors, senescent cells can promote the emergence of cancer stem cells through inflammatory signals released as part of the SASP or through cells escaping from the senescent state. This interaction has been reported in several malignancies, including B-cell lymphoma, liver cancer, colon cancer, lung cancer, and breast cancer, where stem cell-like properties may contribute to tumor progression, metastasis, and resistance to therapy. Full press release - https://www.aging-us.com/news-room/cellular-senescence-and-stem-cells-share-a-more-complex-relationship-than-previously-recognized DOI - https://doi.org/10.18632/aging.206387 Corresponding author - Vassilis G. Gorgoulis - vgorg@med.uoa.gr Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206387 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, senescence, stemness To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Dr. Pinkston sits down with John Jubilee, co-founder of Energized Health, to discuss a groundbreaking, medically approved approach to wellness, fat loss, and cellular longevity. John shares his inspiring personal journey of transforming from a couch-potato dad suffering from severe, bone-on-bone joint pain and hypertension to setting a world record in the chest press at age 65—all without injections, peptides, or synthetic enhancements. Dr. Pinkston and John dive deep into why drinking a gallon of water a day isn't enough if your cells are dehydrated, how intracellular hydration flushes out underlying inflammation (the root cause of modern disease), and why healthy fat loss—not just scale weight loss—is the ultimate key to metabolic health. Plus, John shares practical, actionable "Monday morning" biohacks you can start today to jumpstart your body's natural healing abilities. Key Takeaways From This Episode Intracellular vs. Extracellular Hydration: Why traditional water drinking might be missing your cells completely, and how to turn a "marble-like" cell into a porous sponge. The Power of Circulation: Why the calf muscles are your "second and third hearts" and how moving on the balls of your feet accelerates cellular health. The Truth About Muscle & Aging: Breaking down the myth that we must get weaker as we age, with real-world examples of individuals thriving well into their 90s. Actionable Jumpstart Steps: A breakdown of 4 simple habits you can implement immediately (including nutritional cuts, proper water pacing, and the benefits of MSM). Connect with Our Guest Website: EnergizedHealth.com (Book a discovery call and explore real-life testimonials) Connect with Dr. Pinkston Website: drpbetterlife.com See omnystudio.com/listener for privacy information.

PainExam Podcast Show Notes NAD+ Supplementation in Pain and Inflammation: Hype, Hope, or Emerging Science? Hosted by: PainExam Podcast Presented by: NRAP Academy (Neuromodulation, Regional Anesthesia & Pain) Host: David Rosenblum, MD Episode Overview In this episode of the PainExam Podcast, we explore the growing interest in NAD+ (Nicotinamide Adenine Dinucleotide) supplementation and its potential role in pain management, inflammation reduction, cellular recovery, and healthy aging. NAD+ is a naturally occurring coenzyme found in every living cell and is essential for energy production, mitochondrial function, DNA repair, and cellular resilience. As NAD+ levels decline with age, chronic stress, inflammation, and disease, researchers have begun investigating whether restoring NAD+ levels may improve outcomes in chronic pain conditions and inflammatory disorders. We review the current science, discuss potential mechanisms of action, and examine how NAD+ therapy is being integrated into regenerative medicine, wellness programs, and pain management practices. What is NAD+? NAD+ is a coenzyme involved in: ✅ Cellular energy production (ATP generation) ✅ Mitochondrial health ✅ DNA repair pathways ✅ Oxidative stress reduction ✅ Neuroprotection ✅ Cellular signaling ✅ Activation of longevity-associated proteins called sirtuins Without adequate NAD+, cells become less efficient at producing energy and managing inflammation. Why Might NAD+ Matter in Chronic Pain? Many chronic pain conditions involve: Mitochondrial dysfunction Oxidative stress Neuroinflammation Peripheral and central sensitization Impaired cellular recovery Researchers hypothesize that optimizing NAD+ levels may help address several of these pathways simultaneously. Potential areas of interest include: Neuropathic Pain NAD+ may support: Nerve repair Axonal recovery Mitochondrial function within neurons Reduction of oxidative injury Inflammatory Pain NAD+ influences inflammatory signaling pathways and may help modulate: Cytokine production Immune cell activity Cellular stress responses Fatigue and Recovery Patients with chronic pain frequently report: Fatigue Brain fog Reduced exercise tolerance Poor recovery Because NAD+ plays a critical role in energy metabolism, some clinicians report improvements in energy and recovery following supplementation. Potential Mechanisms of Action 1. Improved Mitochondrial Function Mitochondria generate ATP, the body's energy currency. Reduced NAD+ levels are associated with: Cellular aging Impaired energy production Increased inflammation Supplementation may help restore mitochondrial efficiency. 2. Activation of Sirtuins Sirtuins are proteins involved in: Cellular repair Longevity Metabolic regulation Inflammation control NAD+ serves as a critical substrate for sirtuin activity. 3. DNA Repair Support NAD+ is required for enzymes known as PARPs (Poly ADP Ribose Polymerases), which participate in DNA repair processes following cellular injury. 4. Reduction of Oxidative Stress Chronic inflammation often produces excessive reactive oxygen species (ROS). NAD+ may help maintain cellular antioxidant defenses and reduce oxidative injury. Routes of NAD+ Supplementation Intravenous (IV) NAD+ Most commonly marketed in wellness and recovery clinics. Potential advantages: Direct systemic delivery Avoids gastrointestinal absorption issues Allows higher dosing protocols Potential limitations: Cost Time commitment Variable evidence base Oral Precursors Rather than NAD+ itself, many supplements provide precursors such as: Nicotinamide Riboside (NR) Nicotinamide Mononucleotide (NMN) These compounds are converted into NAD+ within the body. What Does the Evidence Show? Current evidence remains preliminary. While preclinical and mechanistic studies are promising, large-scale randomized controlled trials evaluating NAD+ specifically for chronic pain are still limited. Areas under active investigation include: Neuropathic pain Neurodegenerative disorders Chronic fatigue syndromes Recovery optimization Healthy aging Patients should understand that NAD+ therapy remains an emerging treatment rather than a standard evidence-based pain intervention. Safety Considerations Reported side effects may include: Nausea Flushing Chest tightness during rapid infusions Headache Fatigue Lightheadedness Most adverse effects appear infusion-rate dependent and can often be minimized through slower administration protocols. Patients should discuss treatment with a qualified healthcare professional, especially if they have: Cardiovascular disease Active cancer Significant medical comorbidities Clinical Pearls for Pain Physicians ✔ Consider NAD+ as a potential adjunct—not a replacement—for evidence-based pain care. ✔ Continue emphasizing exercise, sleep optimization, nutrition, behavioral health, and appropriate interventional therapies. ✔ Discuss realistic expectations with patients. ✔ Recognize that evidence continues to evolve. ✔ Focus on patient-centered outcomes rather than laboratory markers alone. Key Takeaways NAD+ is essential for cellular energy production and repair. Declining NAD+ levels may contribute to aging, inflammation, and chronic disease. Early evidence suggests possible benefits in inflammation, recovery, fatigue, and nerve health. Robust pain-specific clinical trials remain limited. NAD+ therapy should currently be viewed as an adjunctive and investigational strategy in pain management. Resources for Physicians Pain Medicine Board Preparation Prepare for the ABA Pain Medicine Boards with:

    PainExam Podcast Show Notes NAD+ Supplementation in Pain and Inflammation: Hype, Hope, or Emerging Science? Hosted by: PainExam Podcast Presented by: NRAP Academy (Neuromodulation, Regional Anesthesia & Pain) Host: David Rosenblum, MD Episode Overview In this episode of the PainExam Podcast, we explore the growing interest in NAD+ (Nicotinamide Adenine Dinucleotide) supplementation and its potential role in pain management, inflammation reduction, cellular recovery, and healthy aging. NAD+ is a naturally occurring coenzyme found in every living cell and is essential for energy production, mitochondrial function, DNA repair, and cellular resilience. As NAD+ levels decline with age, chronic stress, inflammation, and disease, researchers have begun investigating whether restoring NAD+ levels may improve outcomes in chronic pain conditions and inflammatory disorders. We review the current science, discuss potential mechanisms of action, and examine how NAD+ therapy is being integrated into regenerative medicine, wellness programs, and pain management practices. What is NAD+? NAD+ is a coenzyme involved in: ✅ Cellular energy production (ATP generation) ✅ Mitochondrial health ✅ DNA repair pathways ✅ Oxidative stress reduction ✅ Neuroprotection ✅ Cellular signaling ✅ Activation of longevity-associated proteins called sirtuins Without adequate NAD+, cells become less efficient at producing energy and managing inflammation. Why Might NAD+ Matter in Chronic Pain? Many chronic pain conditions involve: Mitochondrial dysfunction Oxidative stress Neuroinflammation Peripheral and central sensitization Impaired cellular recovery Researchers hypothesize that optimizing NAD+ levels may help address several of these pathways simultaneously. Potential areas of interest include: Neuropathic Pain NAD+ may support: Nerve repair Axonal recovery Mitochondrial function within neurons Reduction of oxidative injury Inflammatory Pain NAD+ influences inflammatory signaling pathways and may help modulate: Cytokine production Immune cell activity Cellular stress responses Fatigue and Recovery Patients with chronic pain frequently report: Fatigue Brain fog Reduced exercise tolerance Poor recovery Because NAD+ plays a critical role in energy metabolism, some clinicians report improvements in energy and recovery following supplementation. Potential Mechanisms of Action 1. Improved Mitochondrial Function Mitochondria generate ATP, the body's energy currency. Reduced NAD+ levels are associated with: Cellular aging Impaired energy production Increased inflammation Supplementation may help restore mitochondrial efficiency. 2. Activation of Sirtuins Sirtuins are proteins involved in: Cellular repair Longevity Metabolic regulation Inflammation control NAD+ serves as a critical substrate for sirtuin activity. 3. DNA Repair Support NAD+ is required for enzymes known as PARPs (Poly ADP Ribose Polymerases), which participate in DNA repair processes following cellular injury. 4. Reduction of Oxidative Stress Chronic inflammation often produces excessive reactive oxygen species (ROS). NAD+ may help maintain cellular antioxidant defenses and reduce oxidative injury. Routes of NAD+ Supplementation Intravenous (IV) NAD+ Most commonly marketed in wellness and recovery clinics. Potential advantages: Direct systemic delivery Avoids gastrointestinal absorption issues Allows higher dosing protocols Potential limitations: Cost Time commitment Variable evidence base Oral Precursors Rather than NAD+ itself, many supplements provide precursors such as: Nicotinamide Riboside (NR) Nicotinamide Mononucleotide (NMN) These compounds are converted into NAD+ within the body. What Does the Evidence Show? Current evidence remains preliminary. While preclinical and mechanistic studies are promising, large-scale randomized controlled trials evaluating NAD+ specifically for chronic pain are still limited. Areas under active investigation include: Neuropathic pain Neurodegenerative disorders Chronic fatigue syndromes Recovery optimization Healthy aging Patients should understand that NAD+ therapy remains an emerging treatment rather than a standard evidence-based pain intervention. Safety Considerations Reported side effects may include: Nausea Flushing Chest tightness during rapid infusions Headache Fatigue Lightheadedness Most adverse effects appear infusion-rate dependent and can often be minimized through slower administration protocols. Patients should discuss treatment with a qualified healthcare professional, especially if they have: Cardiovascular disease Active cancer Significant medical comorbidities Clinical Pearls for Pain Physicians ✔ Consider NAD+ as a potential adjunct—not a replacement—for evidence-based pain care. ✔ Continue emphasizing exercise, sleep optimization, nutrition, behavioral health, and appropriate interventional therapies. ✔ Discuss realistic expectations with patients. ✔ Recognize that evidence continues to evolve. ✔ Focus on patient-centered outcomes rather than laboratory markers alone. Key Takeaways NAD+ is essential for cellular energy production and repair. Declining NAD+ levels may contribute to aging, inflammation, and chronic disease. Early evidence suggests possible benefits in inflammation, recovery, fatigue, and nerve health. Robust pain-specific clinical trials remain limited. NAD+ therapy should currently be viewed as an adjunctive and investigational strategy in pain management. Resources for Physicians Pain Medicine Board Preparation Prepare for the ABA Pain Medicine Boards with:

The anti-aging industry is a $59 billion business built on creams, serums, injections, IV drips, and stem cell tourism, and almost all of it is being sold from the outside in, as the actual aging is happening at the level of your DNA, your mitochondria, and the cellular pathways that decide whether your cells protect themselves or wear themselves down over time. Inside today's episode, I walk through the 80/20 breakdown on longevity that most people aren't getting, starting with the identical twin research showing aging is roughly 20% genetic and 80% lifestyle, and the shift in the field from the oxidative stress theory to the current information theory of aging.Topics discussed: - Genetics vs Lifestyle in Aging- The Nine Hallmarks of Aging- The Information Theory of Aging- Sirtuins, AMPK, and mTOR- The Rhythm Between Growth and Repair- Chronological vs Biological Age- Methylation Clocks and Telomere Length- Nutrition, Fasting, and Training Interventions- Sleep, Stress, and Community---------- ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠My Live Program for Coaches: The Functional Nutrition and Metabolism Specialization ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.metabolismschool.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠---------- [Free] Metabolism School 101: The Video Series⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠http://www.metabolismschool.com/metabolism-101⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----------Subscribe to My Youtube Channel: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://youtube.com/@sammillerscience?si=s1jcR6Im4GDHbw_1⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----------⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Grab a Copy of My New Book - Metabolism Made Simple⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠---------- Stay Connected: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram: @sammillerscience⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Youtube: SamMillerScience⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook: The Nutrition Coaching Collaborative Community⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠TikTok: @sammillerscience⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠----------“This Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast and the show notes or the reliance on the information provided is to be done at the user's own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment and is for educational purposes only. Always consult your physician before beginning any exercise program and users should not disregard, or delay in obtaining, medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. By accessing this Podcast, the listener acknowledges that the entire contents and design of this Podcast, are the property of Oracle Athletic Science LLC, or used by Oracle Athletic Science LLC with permission, and are protected under U.S. and international copyright and trademark laws. Except as otherwise provided herein, users of this Podcast may save and use information contained in the Podcast only for personal or other non-commercial, educational purposes. No other use, including, without limitation, reproduction, retransmission or editing, of this Podcast may be made without the prior written permission of Oracle Athletic Science LLC, which may be requested by contacting the Oracle Athletic Science LLC by email at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠operations⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@sammillerscience.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. By accessing this Podcast, the listener acknowledges that Oracle Athletic Science LLC makes no warranty, guarantee, or representation as to the accuracy or sufficiency of the information featured in this Podcast."

For the final episode of The Women's Health Wellness Edit, we sit down with functional medicine expert Dr. John Kim, PharmD, FAARFM to explore why so many people still struggle with brain fog, fatigue, and chronic symptoms despite being "healthy." We dive into the Cell Danger Response, how trauma and chronic stress can impact cellular resilience, and why healing often requires more than diet, supplements, and biohacks. Dr. Kim also walks us through his ENCORE Method for helping the body move out of defense mode and back into healing. This episode is an in-depth and actionable look at how to take control of your body back. Keep in touch with Dr. Kim: https://www.drjohnkim.com https://www.instagram.com/john.pharmd/?hl=en Attend Dr. Kim's upcoming webinar: https://beyonddetox.drjohnkim.com If this episode spoke to you, subscribe and leave a review on your favorite podcast platform or share it with a friend! podcasts.apple.com/us/podcast/slig…od/id1542525641 Follow us on Instagram: www.instagram.com/slightlyspiritualpod/ Follow Cindy on Instagram: www.instagram.com/revealingsoul/ Follow Ali on Instagram: www.instagram.com/alitmoresco/

This week I interviewed Dr. Adrijana Kekic!  She is the founder of Futurama, which applies integrated genetic, metabolic, and molecular analysis to individuals who look healthy on paper but feel metabolically stuck, fatigued, or inflamed. We discussed the concept of “cellular drift”, and how dysfunction progresses silently despite normal labs along with: - the importance of understanding fasting insulin  - how she leverages AI to create your roadmap to health - the benefits and downsides to peptidesand her one tip to get your body back to what it once was!Connect with Dr. Kekic: https://www.futurome.com/---FREE Pro-Metabolic Window Eating Guide:https://brian-getleaneatclean.beehiiv.com/subscribeClick to book a FREE 15 minute consult with Brian:https://calendly.com/bdgryn/15min----Interested in Upgrading your Mitochondria, Improving Energy and Sleep! Check out Troscriptions: https://bit.ly/4ik5kK5Use Discount Code for 10% OFF: EATCLEAN----If you're serious about building strength and muscle while protecting your joints, grab the B Strong Blood Flow Restriction bands I use and recommend:Go Here: https://bit.ly/4ektMvGUse Coupon Code: BRIANGRYN-----How to Take Simple Steps to Reclaim the Body, Energy, and Strength You Had 10-15 Years Ago Using My Stepladder System:https://www.stepladdersystem.com/----B.rad Whey Protein Isolate Superfuel:The Best Protein on The Planet! Available in Two Delicious Flavors: Vanilla Bean and Cocoa BeanUse Coupon Code glec10off for 10% off your order!https://a.co/d/731gssV----My favorite health bars with clean ingredients!https://www.eatprima.com/BRIAN6816310% OFF with this link!

What if fatigue, brain fog, slow recovery, and burnout aren't simply a lack of motivation—but a reflection of what's happening deep within your cells? In this Wellness Illuminated episode of Light Body Radio, Dr. Lara May explores the fascinating world of mitochondrial health, cellular energy production, and the role peptides can play in supporting resilience, healing, and healthy aging. You'll learn how the body creates ATP—the cellular energy currency that powers every process in the body—and why mitochondrial function is essential for everything from brain health and detoxification to recovery and repair. Dr. Lara also breaks down the relationship between NAD+, methylene blue, mitochondrial signaling, and why more isn't always better when it comes to supporting energy pathways. This episode offers a practical, science-informed look at how cellular energy impacts overall health and what it means to support your body intelligently rather than simply chasing more energy. © Light Body Radio-Podcast, 2026. All rights reserved. This podcast features background music by ScottHolmes Music. We have obtained the necessary licenses for the use of this music. Our license was renewed on May 7, 2024, and we have been using ScottHolmes Music since 2017. Unauthorized use or distribution of this podcast, including but not limited to the background music, is strictly prohibited and may result in legal action. For more information or to request permissions, please contact scott@scottholmesmusic.com.

Our bodies are designed with remarkable systems to protect, repair, and renew themselves. Yet modern life exposes us to physical, emotional, and environmental stressors that can place additional demands on these natural processes. The founder of Alimtox Wellness, Paula Childers, understands firsthand how detoxification at a cellular level can be lifechanging. By understanding how the body’s detoxification pathways support cellular function, energy production, and overall vitality, we can begin to appreciate the importance of creating habits that encourage balance and resilience. Paula will share how supporting the body’s natural cleansing processes can help us feel more energized, refreshed, and empowered in our wellness journey. Now you can listen commercial free at your leisure…Click here and let's grow together: Detoxification at a Cellular Level with Alimtox Wellness,  Paula Childers If you love this podcast episode, share it with a friend. The Lillian McDermott Radio Show/Classroom ~ When You Need a Friend… PREMIERE:  Telegram, Facebook, YouTube, WhenYouNeedaFriend.com SUBSCRIBE, LIKE, & FOLLOW:    Facebook, Instagram, X, Website, Odysee, BitChute, YouTube! LISTEN:  Amazon Podcast, Apple Podcasts, YouTube Music, Spotify, Pandora, TuneIn, iHeartRadio! CALL or TEXT: 407-373-5959 “You can take a pill, or You can take Responsibility!” ®

When summer skin starts looking dull, congested, tired, or slower to recover, it is easy to blame the obvious things: heat, sweat, sunscreen, long days outside, or the wrong moisturizer. So the conversation usually stays on the surface. Use SPF. Cleanse better. Switch to lighter products. Add antioxidants. But before we treat summer skin like another product problem, there is a deeper question worth asking: what is the sun doing to the cell before you ever see the damage in the mirror?In this episode of Biohacking Beauty, I want to take the sun conversation past burns, wrinkles, and dark spots. I'm walking through what UV exposure does to the systems your skin depends on to keep up with summer: cellular energy, NAD, mitochondrial function, and DNA repair. Because the skin does not only need protection from the sun. It also needs enough repair capacity to deal with the damage that gets through.Young Goose's Skin Under the Sun campaign is active from June 15 through June 28 at younggoose.comWhat's Discussed:(01:50) The light-activated repair tool humans lost.(06:10) Why NAD matters for skin energy and repair.(10:15) How UV exposure increases oxidative stress and disrupts NAD supply.(16:44) What UV-induced DNA lesions are and why CPDs matter.(22:21) Why L.A.D.R. serum was built around light-activated repair-inspired science.(31:52) Why the sun is one of the biggest controllable inputs into biological skin aging.(35:43) The five protocol-level moves for supporting skin through summer.Listen to this episode of Biohacking Beauty to understand what UV is doing under the surface and how to build a smarter summer protocol around protection, energy, and repair.Resources Mentioned:Age-Associated Changes in Oxidative Stress and NAD+ Study: journals.plos.org/plosone/article/FASEB study on how methylene blue delays cellular senescence cells: faseb.onlinelibrary.wiley.com/doi/Find more from Young Goose:Use code PODCAST10 to get 10% OFF your first purchase, and if you're a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincare

Interview starts 41:40 In this episode, Dr. Alicia Newsome shares her inspiring journey from struggling with fibromyalgia to becoming a leading advocate for holistic and functional medicine tailored to women's health. Discover practical insights on hormonal balance, gut health, parasite cleansing, and how advanced testing can revolutionize personalized care. Dr. Alicia Newsome is a functional medicine practitioner and lifestyle physician specializing in root-cause, personalized care for women. She focuses on issues like hormone balance, periods, fertility, detoxification, and overall wellness, often addressing why conventional medicine may fall short in providing lasting solutions. https://www.dralicianewsome.com/ MEN: https://go.dralicianewsome.com/men-optimization-cap WOMEN: https://go.dralicianewsome.com/hormone-reset-plan-direct FERTILITY: https://go.dralicianewsome.com/fertility-action-plan-direct Worthy of Rest: https://go.dralicianewsome.com/checkout-worthy-of-rest Main Topics: Dr. Alicia's journey from conventional medicine to holistic healing Root causes of chronic women's health issues like fibromyalgia, PCOS, endometriosis The influence of toxins, gut health, and stress on hormonal balance The importance of advanced lab testing (Dutch test, comprehensive panels) Natural protocols for detoxification, parasite cleansing, and hormone regulation The role of mental health, gratitude, and lifestyle in physiological health Challenges within mainstream healthcare and advocacy for proactive, personalized care Become a Lord or Lady with 1k donations over time. And a Noble with any donation. Leave Serfdom behind and help Grimerica stick to 0 ads and sponsors and fully listener supported. Thanks for listening!! Help support the show, because we can't do it without ya. https://www.simulationmaps.com/#products Suite of Interactive Maps! DisasterMap, VolcanoSim, AsteroidSim, ShipwreckMap, UFOMap etc https://www.amazon.com/Unlearned-School-Failed-What-About/dp/1998704904/ref=sr_1_3?sr=8-3   Support the show directly: https://open.spotify.com/show/2punSyd9Cw76ZtvHxMKenI?si=ImKxfMHgQZ-oshl499O4dQ&nd=1&dlsi=4c25fa9c78674de3 Watch or Listen on Spotify https://grimericacbd.com/ CBD / THC Gummies and Tinctures http://www.grimerica.ca/support https://www.patreon.com/grimerica http://www.grimericaoutlawed.ca/support   Our audio book website: www.adultbrain.ca Check out our next trip/conference/meetup - Contact at the Cabin www.contactatthecabin.com www.grimerica.ca/shrooms and Micro Dosing Darren's book www.acanadianshame.ca Join the chat / hangout with a bunch of fellow Grimericans Https://t.me.grimerica grimerica.ca/chats   Discord Chats https://itunes.apple.com/ca/podcast/grimerica-outlawed Sign up for our newsletter https://grimerica.substack.com/ SPAM Graham = and send him your synchronicities, feedback, strange experiences and psychedelic trip reports!! graham@grimerica.com Purchase swag, with partial proceeds donated to the show: www.grimerica.ca/swag Send us a postcard or letter http://www.grimerica.ca/contact/ Episode ART - Napolean Duheme's site http://www.lostbreadcomic.com/ MUSIC https://brokeforfree.bandcamp.com/ - Something Galactic Felix's Site sirfelix.bandcamp.com - Should I           Timestamps: (00:00) - Introduction: From fibromyalgia diagnosis to holistic health advocate (02:10) - Dr. Alicia's early struggles with conventional fibromyalgia treatment (07:12) - Root causes of autoimmune and inflammatory diseases (09:31) - Stress, gut health, and inflammatory drivers (11:27) - Mental health and gratitude practices affecting physiology (14:22) - Hormonal imbalances during peri/menopause and gut-hormone connection (16:17) - Addressing estrogen detox pathways for women's health (17:46) - Main health concerns for women: weight resistance, energy, mood (20:22) - Impact of sleep, diet, and circadian rhythms (22:41) - Cellular detoxification protocols and detox myths (23:50) - Parasite cleansing stories and lunar timing (25:54) - How parasite cleanses can resolve hormonal issues (32:42) - Sex differences: Why women experience chronic health issues differently (34:19) - Hormonal cycle phases and stress impacts (36:17) - Main blood and functional testing recommendations (39:28) - The 90-day personalized health reset process (44:34) - Addressing mainstream healthcare failures and advocating for personalized testing (50:43) - Advanced testing for hormones, toxins, and genetics (58:15) - Resources: How to connect with Dr. Alicia and access her programs (60:32) - Wrap-up and final thoughts: Rest as a foundation of health                        

I sit down with nutrition scientist Dr. Luke Bucci to explore the powerful connection between blood flow, nitric oxide, mitochondrial health, and healthy aging. We discuss why circulation impacts nearly every function in the body, what causes energy levels to decline with age, and how nutrition, exercise, and targeted supplementation may help support long-term vitality. Dr. Bucci also explains the science behind nitric oxide, blood sugar regulation, and the role mitochondria play in keeping us energized and resilient throughout life.Dr. Luke Bucci, PhD, CNS, CCN is the Chief Scientific Officer of Juvenon and a biomedical scientist with more than 40 years of experience in nutrition, dietary supplements, and clinical laboratory science. He earned his PhD in Biomedical Sciences from the University of Texas Health Science Center at Houston and has helped develop numerous patented nutritional products used worldwide. A recognized authority in healthy aging, sports nutrition, omega-3s, probiotics, and dietary supplement science, Dr. Bucci has authored scientific books, taught university-level courses, and received multiple industry awards for his contributions to nutrition and health innovation.Links mentioned during this episode:Juvenon: https://juvenon.com/Free Initial Consultation with Dr. Megan: https://p.bttr.to/3a9lfYkLyons' Share Instagram: www.instagram.com/thelyonsshareJoin Megan's newsletter: www.thelyonsshare.org/newsletter

You already know that ultra-processed foods aren't good for you. But do you know what they're actually doing inside your cells? In this episode of The Science of Self-Healing, we take a deep look at one of the most consequential — and overlooked — consequences of the modern diet: mitochondrial dysfunction. Your mitochondria do far more than produce energy. They regulate inflammation, support detoxification, balance hormones, and govern the body's ability to heal itself. And ultra-processed foods are disrupting all of it. From blood sugar instability and oxidative stress to gut microbiome damage, nutrient depletion, and toxic burden, we explore the cascade of mechanisms through which these foods quietly erode cellular function — often years before a chronic disease diagnosis appears. This episode also covers what a bioregulatory approach to mitochondrial restoration actually looks like, and why healing this damage begins not in a doctor's office, but on your plate.

Senescence: How Cellular Aging May Influence Periodontal DiseaseBy Hannah Neumann, RDHOriginal article published on Today's RDH: https://www.todaysrdh.com/senescence-how-cellular-aging-may-influence-periodontal-disease/Need CE? Start earning CE credits today at ⁠https://rdh.tv/ce⁠ Get daily dental hygiene articles at ⁠https://www.todaysrdh.com⁠ Follow Today's RDH on Facebook: ⁠https://www.facebook.com/TodaysRDH/⁠Follow Kara RDH on Facebook: ⁠https://www.facebook.com/DentalHygieneKaraRDH/⁠Follow Kara RDH on Instagram: ⁠https://www.instagram.com/kara_rdh/⁠

Myoscience Creatine with 20% off: https://bit.ly/43EWGRc   Pre-order Keto Flex Revised and get free bonuses at: https://bit.ly/4wKG1sM    I'm 41 and I Feel Younger Than I Did at 25. The 5 Exercises Behind It. People who can lower themselves to the floor and stand back up cleanly have a roughly 3 to 4% risk of dying in a given follow-up period. People who struggle? 42%. That's the kind of longevity signal no blood test or gadget can match, and you can run it in your living room in 10 seconds. In this episode, I share the five exercises that have helped me feel genuinely younger at 41 than I did at 25. Not because of genetics or living in the gym, but because I stopped letting critical movements disappear. Each one targets a specific ability that fades first: energy, mobility, strength, power, and the single movement that predicts long-term independence. I also share the Mayo Clinic study on mitochondria and HIIT that showed older bodies responding more than younger ones to training, why power declines almost twice as fast as strength after 40, and the personal moment with my German Shepherd Ziggy that forced me to take hip hinge strength seriously. Key Takeaways: Most people don't get old first. They get weak first. Accelerated aging is driven by the movements you stop practicing. Mayo Clinic research showed older adults boosted cellular energy capacity by 69% on HIIT, compared to 49% in younger adults. Power (force produced quickly) fades nearly twice as fast as strength after 40, and people with low power have nearly 6x the risk of dying. The sit-to-stand floor test separates a 3 to 4% mortality risk from a 42% one. It tests everything, leg strength, mobility, balance, and coordination, in one movement. Single-leg balance for 10 seconds is one of the most sensitive aging signals available and almost nobody is checking it. After age 30, natural creatine production declines, making recovery, strength, and brain function harder to maintain without supplementation. Find All The Ben Azadi Show Sponsorship Deals ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.ketokamp.com/sponsorship-deals Learn more about your ad choices. Visit megaphone.fm/adchoices

Vickie Johnston is the founder of H2O Health and a passionate advocate for clean water and preventative wellness. Drawing on a background in medical laboratory science and years of research into environmental health, she has dedicated her career to educating people about the impact water quality has on overall well-being. Through H2O Health, Vickie helps families reduce toxic exposures and create healthier homes with science-based water solutions and practical health education.   In this episode, Dr. Brian and Vickie talk about…   (00:00) Intro (03:44) How Vickie first became aware of how toxic so much of our drinking water is (06:02) How chlorine in water effects your health (08:23) Microplastics an pH balance (09:07) Stress (11:39) Cellular health (12:18) Human touch, community, and giving back (14:26) The speaker lineup at the upcoming 2026 HEALTH SUMMIT (links below) (27:16) More details about the health summit (31:40) The new MVX+ test (34:20) Final details on the 2026 HEALTH SUMMIT (35:57) Outro   For more information, please see the links below. Thank you for listening!   Links:   Resources Mentioned in this Episode: Brain Builders: https://brainbuilders.health   Vickie Johnston: H20 Health: https://h2ohealth.com 2026 HEALTH SUMMIT: https://brainbuilders.health/2026-Health-Summit/?fbclid=IwY2xjawSXvSZleHRuA2FlbQIxMABicmlkETFIc1BaUTlRQzBHYkIwYVVRc3J0YwZhcHBfaWQQMjIyMDM5MTc4ODIwMDg5MgABHkbO_GDPQUEsZCpWQJXvRrRd4yJW_3tOOLnIKgPC0DMMCQKSwiFgfvliv_Zq_aem_njsmfBONCHXmndPcHrmp2Q   Dr. Brian Lenzkes:  Arizona Metabolic Health: https://arizonametabolichealth.com/ Low Carb MD Podcast: https://www.lowcarbmd.com/   HLTH Code: HLTH Code Promo Code: METHEALTH HLTH Code Website: https://gethlth.com

What if the reason your cells are breaking down isn't a mystery - it's simply a lack of oxygen? In this episode of Integrative Cancer Solutions, Dr. K sits down with Teresa Reile, cancer survivor, hypoxia specialist, and founder of Patriox Health Freedom, to share a story that goes far beyond a diagnosis. After surviving cervical cancer in 2012 while managing 48 companies and going through a divorce, Teresa discovered a decade later that the cancer had returned - silently. What she found in Hungary, a drinkable and bathable oxygen technology developed over 25 years, cleared her scan results in under three weeks. Now she's brought that technology to the United States. This conversation covers the real root cause most doctors never test for, why cellular hypoxia underlies nearly every chronic condition, how the HIF-1 alpha test can detect it before disease takes hold, and why oxygen may be the most overlooked nutrient in modern medicine. Key Takeaways: 0:00 Introduction  1:27 Running 48 companies, a divorce, and a cancer diagnosis  3:20 Getting the news and still making it to the wedding  5:08 What the medical system got wrong after surgery 10:28 When cancer came back a decade later  13:42 Cellular hypoxia and how it starts the disease process  28:23 Why cancer hates oxygen and what that means for treatment 37:30 Words of wisdom for high-achieving entrepreneurs  Schedule a Free 15-Min Cancer/Lyme Consultation at The Karlfeldt Center: 208-338-8902 Resources: Patriox Health Freedom — https://patriox.us/ Medical Disclaimer: This content is for educational purposes only and is not intended to diagnose, treat, cure, or replace professional medical advice. Always consult your physician or qualified healthcare provider regarding any medical condition or treatment decisions. ____________________________________RESOURCES FROM DR. KARLFELDT:

You might think that once you tear out the moldy drywall and move into a clean house, your body finally gets to heal, but in this episode, Dr. John Kim and I get into why so many people do everything right and still can't shake the brain fog, the fatigue, and the gut chaos. The answer lives somewhere most testing never looks: a stuck "cell danger response," where your cells stay locked in defense mode like a fire alarm that won't stop blaring long after the fire is out. I'll walk you through how Dr. Kim uses his ENCORE method to finally shut that alarm off, because you can't out-biohack a body that's still convinced it's under attack. CLICK HERE TO BECOME GARY'S VIP!: https://bit.ly/4ai0Xwg Connect with Dr. John Kim Website: https://bit.ly/4x4xGAg  YouTube: https://bit.ly/4aqYgd0  Instagram: https://bit.ly/4acnBr7  Facebook: https://bit.ly/49G7KRt  TikTok: https://bit.ly/4xqaPQ3  X: https://bit.ly/3PFmMjN  Thank you to our partners A-GAME: “ULTIMATE15” FOR 15% OFF: http://bit.ly/4kek1ij  AION: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4h6KHAD  AIRES: "ULTIMATE20 " FOR 20% OFF: https://bit.ly/4a3Duze  BAJA GOLD: "ULTIMATE10" FOR 10% OFF: https://bit.ly/3WSBqUa  BODYHEALTH: “ULTIMATE20” FOR 20% OFF: http://bit.ly/4e5IjsV  COLD LIFE: THE ULTIMATE HUMAN PLUNGE: https://bit.ly/4eULUKp  CYMBIOTIKA: "ULTIMATE10" FOR 10% OFF: https://bit.ly/4tjyluP  GENETIC METHYLATION TEST (UK ONLY): https://bit.ly/48QJJrk  GENETIC TEST (USA ONLY): ⁠https://bit.ly/3Yg1Uk9  GOPUFF: GET YOUR FAVORITE SNACK!: https://bit.ly/4obIFDC  H2TAB: “ULTIMATE10” FOR 10% OFF: https://bit.ly/4hMNdgg  HEALF: 10% OFF YOUR ORDER: https://bit.ly/41HJg6S  PEPTUAL: “TUH10” FOR 10% OFF: https://bit.ly/4mKxgcn  SNOOZE: LET'S GET TO SLEEP!: https://bit.ly/4pt1T6V  WHOOP: JOIN & GET 1 FREE MONTH!: https://bit.ly/3VQ0nzW  Watch  the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST: YouTube: https://bit.ly/3RPQYX8 Podcasts: https://bit.ly/3RQftU0 Connect with Gary Brecka Instagram: https://bit.ly/3RPpnFs TikTok: https://bit.ly/4coJ8fo X: https://bit.ly/3Opc8tf Facebook: https://bit.ly/464VA1H LinkedIn: https://bit.ly/4hH7Ri2 Website: https://bit.ly/4eLDbdU Merch: https://bit.ly/4aBpOM1 Newsletter: https://bit.ly/47ejrws Ask Gary: https://bit.ly/3PEAJuG Timestamps 00:00 Intro of Show  04:30 Dr. John Kim's Back Story: Heart Attack  10:42 What to Do When You Discover Mold in Your System?  19:13 Testing for Mold Toxicity  31:26 Cell Danger Response: Definition, Testing, and Resolution  35:59 The ENCORE Method  38:26 E - Environmental Factors Affecting Health  47:45 N - Nervous System Regulation  52:18 C - Cellular Integrity  56:07 Stress Response Increasing Deuterium Production  1:00:24 O - Optimizing Detox  1:05:47 RE - Rebalancing the Microbiome & Enhancing Resilience  1:10:12 What does it mean to you to be an Ultimate Human? Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions.  Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation.  Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered promotional in nature. Learn more about your ad choices. Visit megaphone.fm/adchoices