Podcasts about nexvax2

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Latest podcast episodes about nexvax2

A Gluten Free Podcast
Dr Bob Anderson on Coeliac Disease Research, Immune Response & Future Treatments

A Gluten Free Podcast

Play Episode Listen Later Apr 20, 2025 79:45


A Gluten Free PodcastEpisode 176On today's episode I chat with Associate Professor Dr Bob Anderson — a world-renowned gastroenterologist, immunologist and trailblazer in coeliac disease research. From his foundational work at the Walter and Eliza Hall Institute (WEHI) to creating Nexvax2, leading Novoviah Pharmaceuticals, and becoming President of the International Society for the Study of Coeliac Disease (ISSCD), Bob has shaped the coeliac research landscape as we know it.We discuss how his career began, what he's most excited about in current research, and what's ahead for coeliac disease globally — including a look at ICDS 2026 in Melbourne.What We Cover

Talking Gut with Dr Jim Kantidakis
Ep 17 Assoc Prof Jason Tye-Din on Coeliac Disease

Talking Gut with Dr Jim Kantidakis

Play Episode Listen Later Jul 28, 2019 60:56


Dr Tye-Din is a gastroenterologist with a clinical and research interest in Coeliac disease. He heads the Coeliac Research Lab at the Walter and Eliza Hall Institute, runs a Coeliac clinic at the Royal Melbourne Hospital and is an Honorary Research Fellow at the Murdoch Children’s Research Institute. His PhD employed feeding studies to characterise gluten immunity that underpinned development of a novel immunotherapy for Coeliac disease, Nexvax2. His research interests include understanding the immune and genetic basis for coeliac disease and how gluten tolerance is lost, the role of the microbiome, understanding why the gluten-free diet can fail, and developing and testing novel diagnostics and treatments. He is on the editorial board of Alimentary Pharmacology and Therapeutics and consults for an industry partner (ImmusanT Inc.) who are leading the development of Nexvax2. Jason chairs the Medical Advisory Committee of Coeliac Australia and is involved in patient advocacy, clinical guideline development and medical education. In todays talk, we covered a lot. There was so much about coeliac disease that I didn’t know, and so, I think a lot of people, medical professionals as well as individuals managing this disease, will find this episode really interesting and helpful. So what did we cover? We talked about What Coeliac disease is? Its Incidence and prevalence ? Age of onset ? What the symptoms are ? The potential complications of undiagnosed untreated coeliac disease? Why a gluten free diet may sometimes be unsuccessful in reducing complications The different ways to diagnose Coeliac disease? Why Coeliac disease can be under diagnosed The overlap between Coeliac disease and functional gut disorders The difference between Coeliac disease and Non-Coeliac Gluten Hypersensitivity We also talking about his exciting new research in developing a vaccine, called the Nexvax2 We talked about the research looking at utilising the hook worm to manage the disease What is important for a person managing Coeliac disease or newly diagnosed to know? What would be take home message for health professionals ? and...a whole lot more... Please enjoy my conversation with Dr Jason Tye-Din

The Celiac Project Podcast
The Celiac Project Podcast - Ep 181: 2 Guys Talking Gluten Free

The Celiac Project Podcast

Play Episode Listen Later Jul 24, 2019 32:47


After finding that Nexvax2 did not provide, "meaningful protection from gluten exposure when compared with placebo," ImmusanT pulled the plug on their trial. Mike and Cam share their thoughts and also discuss a highly informative article written by Kelly Carter, a participant in the study. In the end, we are optimistic that more good will come out of this down the line, and we talk about why trials like these are so important to help us hopefully find a cure for celiac disease.

A Canadian Celiac Podcast
Ep 83 Nexvax2 - What's Next?

A Canadian Celiac Podcast

Play Episode Listen Later Jul 10, 2019 40:54


On Episode 76 of the podcast, I spoke with Kristen Kneff from ImmunsanT about the presentation she gave at The State of Celiac event held in May by the Canadian Celiac Association.  Kristen's presentation, and our subsequent interview looked at the Phase 2 trial for Nexvax2, a vaccine to minimize the effects of gluten on those with celiac disease.  Recently, the trial was halted, as the vaccine was not performing as expected. Ellen Bayens of theceliacscene.com brought this to my attention in an article looking at both the press release from ImmunsanT and a position piece from Dr. Peter Green.  On this episode of the podcast, Ellen and I speak about what this news means for the research community as well as the impact on the celiac community. You can read the article at the following link – http://bit.ly/Nexvax2announcement   Sue's Websites and Social Media – Podcast https://acanadianceliacpodcast.libsyn.com Podcast Blog – https://www.acanadianceliacblog.com Facebook - @acanadianceliacpodcast Twitter – CeliacPodcastCA Email – acdnceliacpodcast@gmail.com Baking Website – https://www.suesglutenfreebaking.com Instagram - @suesgfbaking YouTube - https://www.youtube.com/playlist?list=PLUVGfpD4eJwwSc_YjkGagza06yYe3ApzL      (search Sues Gluten Free Baking) Email – sue@suesglutenfreebaking.com Other Podcast – Gluten Free Weigh In – https://glutenfreeweighin.libsyn.com

A Canadian Celiac Podcast
Ep 83 Nexvax2 - What's Next?

A Canadian Celiac Podcast

Play Episode Listen Later Jul 10, 2019 40:54


On Episode 76 of the podcast, I spoke with Kristen Kneff from ImmunsanT about the presentation she gave at The State of Celiac event held in May by the Canadian Celiac Association.  Kristen's presentation, and our subsequent interview looked at the Phase 2 trial for Nexvax2, a vaccine to minimize the effects of gluten on those with celiac disease.  Recently, the trial was halted, as the vaccine was not performing as expected. Ellen Bayens of theceliacscene.com brought this to my attention in an article looking at both the press release from ImmunsanT and a position piece from Dr. Peter Green.  On this episode of the podcast, Ellen and I speak about what this news means for the research community as well as the impact on the celiac community. You can read the article at the following link – http://bit.ly/Nexvax2announcement   Sue's Websites and Social Media – Podcast https://acanadianceliacpodcast.libsyn.com Podcast Blog – https://www.acanadianceliacblog.com Facebook - @acanadianceliacpodcast Twitter – CeliacPodcastCA Email – acdnceliacpodcast@gmail.com Baking Website – https://www.suesglutenfreebaking.com Instagram - @suesgfbaking YouTube - https://www.youtube.com/playlist?list=PLUVGfpD4eJwwSc_YjkGagza06yYe3ApzL      (search Sues Gluten Free Baking) Email – sue@suesglutenfreebaking.com Other Podcast – Gluten Free Weigh In – https://glutenfreeweighin.libsyn.com

Gluten Free News
Vaccine protects against high doses of gluten

Gluten Free News

Play Episode Listen Later Jun 19, 2019 3:21


Nexvax2, a vaccine being developed to treat celiac disease, induced tolerance of even high doses of gluten peptides in celiac disease patients.Read the full article here: https://www.beyondceliac.org/research-news/vaccine-protects-against-high-doses-of-gluten/ See acast.com/privacy for privacy and opt-out information.

Empowered Patient Podcast
Developing a Therapeutic Vaccine for Celiac Disease with Bob Anderson ImmusanT

Empowered Patient Podcast

Play Episode Listen Later May 28, 2019 18:22


Bob Anderson PhD, Chief Scientific Officer, ImmusanT is an internationally recognized leader in celiac disease research.  He talks about the underlying causes of celiac, who is most likely to have an acquired immune response to fragments of the gluten protein, educating doctors about the need to test for celiac, the Phase 2 clinical trial results for Nexvax2 a therapeutic vaccine to treat celiac, and how the ImmusanT platform technology is allowing development of therapeutic vaccines for diabetes and other autoimmune conditions. @ImmusanT #celiac  #celiacdisease #diabetes  #autoimmunediseases #tcell  #glutenpeptides  #peptides  #gluten  #immunology ImmusanT 

Medical Intel
Celiac Disease

Medical Intel

Play Episode Listen Later Nov 29, 2018 14:19


Doctors know that celiac disease is a real medical condition, but too many people treat it like a trendy diet choice. Dr. Z. Jennifer Lee discusses the dangers of gluten exposure in patients with celiac disease.   TRANSCRIPT Intro: MedStar Washington Hospital Center presents Medical Intel where our healthcare team shares health and wellness insights and gives you the inside story on advances in medicine. Host: Thank you for joining us today. We’re talking with Dr. Jennifer Lee, a gastroenterologist at MedStar Washington Hospital Center. Welcome, Dr. Lee. Dr. Jennifer Lee: Hello! Nice to be here. Host: Today we’re talking about treatment options for celiac disease, an autoimmune disorder in which patients suffer intestinal damage after eating gluten, a protein found in wheat, barley and rye. There are currently no effective celiac disease treatments approved by the Food and Drug Administration, but a promising new drug is headed into phase two clinical trial. Dr. Lee, could you give us a brief overview of what celiac disease is and how it affects patients’ quality of life? Dr. Lee: Sure. Celiac disease is a disease process which falls under the spectrum of gluten-related disorders. It is something that we know a lot about. It’s a genetically-based disease. It happens to genetically susceptible individuals where upon intake of gluten, they can get a reaction. It’s an immune mediated reaction. And so, what we used to tell patients, was that they were allergic to gluten. So, as we delve a little bit deeper into the topic today we’ll see that there are other gluten-related disorders that result in symptoms even without the diagnosis of celiac disease. So, another one would be wheat allergy. And another one that is actually quite commonly talked about these days is non-celiac gluten sensitivity. But getting back to celiac disease, the patients can manifest in many different ways--It can be chronic diarrhea, it could be bloating, it can iron deficiency anemia. And so, it needs to be on our minds when we see patients with these possibly non-specific symptoms. Host: Why is the advancement of this drug, Nexvax2®, into phase two clinical trial exciting for the celiac community? Dr. Lee: So, it’s exciting and not. Right now, as you mentioned, there are no medications for celiac disease. We have a very good treatment for celiac disease and it’s dietary--we avoid gluten, and it works for the vast majority of our patients with celiac disease. But, the difficulty is inadvertent gluten intake. Sometimes there’s cross contamination if you’re eating out. It can be an issue, and so I think it would be nice to have some sort of medication that helps with that. It’s also important to remember, though, that this is a phase two trial, and so, again, the majority of drugs that go in to phase two trials actually don’t make it past phase two. So, while it is exciting, I think we have to keep in mind that the most important thing is gluten avoidance. Host: How is it that a disease as common and well-known as celiac disease has no effective treatments? Dr. Lee: I think it’s because it’s a complex disease. It’s a genetically based disease. However, not everybody who has the genetic predisposition gets celiac disease. It’s a very complex thing, and where you have the propensity, genetically, and then you have other factors, and we’re not entirely sure what all those factors are. And so, it’s difficult to pinpoint or target something exactly. The medication that’s in trial now, the target would be a genetic target but, we don’t know with 100 percent clarity what causes it. So, it’s hard to say. Host: How long would a person have to suffer symptoms before they go see a gastroenterologist for a possible celiac diagnosis? Dr. Lee: You know, I’ll be honest with you, I’ve seen the whole spectrum. I’ve seen patients who’ve had diarrhea for many months without a diagnosis and they come and we’ve made the diagnosis at that point. But I’ve also seen patients who don’t really know that they’re anemic and they have iron deficiency anemia and we find that on testing and we’ve been able to make a diagnosis that way. Host: What are some of the common and more uncommon symptoms of celiac disease? Dr. Lee: Within celiac disease, very commonly we’ll have chronic diarrhea, weight loss, joint pains, even headache, rashes. So, as you can see, some of them can be very non-specific. And the important thing to note here is even across the different gluten-related disorders, you can get these types of symptoms. For instance, non-celiac gluten sensitivity and celiac disease can both present with brain fog - that’s a very common complaint that you hear about. So, very important that patients with these symptoms see a gastroenterologist and nail down a diagnosis. Host: How can gastroenterologists help patients understand whether they have celiac disease or another gastrointestinal condition? Dr. Lee: There are significant differences in long-term health consequences, depending on what you are diagnosed with. It’s very important to be diagnosed with celiac disease because, down the road, you need to be monitored for certain things like autoimmune diseases, even certain cancers, down the line. Whereas non-celiac gluten sensitivity and even wheat allergy may not necessarily result in this same long-term sequelity. Host: If a person’s really struggling with these symptoms, what would you recommend as their first action to get care? Dr. Lee: To definitely come see a healthcare professional. Whether that be their primary care doctor or if they want to come straight to a gastroenterologist, that’s...you know, we are happy to see these patients. Diagnosis involves some blood testing, and, in most cases, an upper endoscopy, where we take samples of the small intestine to evaluate for any signs of inflammation. Host: Could you talk a little bit about your patient population? Dr. Lee: Absolutely yes. I would say, when we first started learning about celiac disease, you would think that it was a disease found only in Caucasians or those of European ancestry. But now we’ve learned that really it can be in any population, any race. And, to follow that, it’s in anybody of any age. It’s commonly diagnosed in childhood, but I have made plenty of diagnoses in adulthood. Host: What kind of damage do you see in your patients after years and years of symptoms? Dr. Lee: I think the most dramatic patient I’ve seen, and dramatic being that when I first met him, he was emaciated. I mean, he had lost so much weight. He showed me a picture of his driver’s license and how he was before his symptoms started - and they didn’t start until he was in his 40s. But he looked like a completely different person. The weight loss was very marked. And so, after making the diagnosis and after starting him on a gluten free diet, and seeing him in follow-up afterwards, it was like seeing a brand-new person. It was amazing. I still keep in touch with him, to this day, you know, there’s not much that I need to do for him now that he knows exactly what he can eat, what he can’t eat. He has appropriate follow-up. We check his vitamin levels once in a while. But, I think it’s just...it’s such a great feeling when you see that they have returned to, you know, their normal life. Yes, they need to change the way they eat but it’s possible to feel healthy and to feel like you can go out and have a normal life. There’s data to suggest that, in children, the thought of having celiac disease produces anxiety and reduces quality of life. And so, we know it is something that people think about and worry about so I think, you know, even in the quality of life aspect--eating out, being social--it’s rewarding to see that we can, you know, get someone to that point. Host: How is it that a disease that has genetic components can manifest so late in somebody’s life? Dr. Lee: There’s so much that we still don’t understand about celiac disease. We are not sure why, in one person, it would manifest in childhood and another it manifests in adulthood. Host: What do you say to people who say, “Oh, celiac disease is just a trend and it’s not real.” Dr. Lee: I think I just tell them what we know, based on the evidence that we have. What trials we’ve done. And I explain to them that there IS a spectrum of gluten related disorders - celiac disease, wheat allergy, non-celiac gluten sensitivity. And, you know, it can be a bit of a fad thing. I mean, right now we’re all hearing about a gluten free diet. I would say that many people who are on a gluten free diet don’t have a gluten related disorder. But there are a subset of people who don’t have celiac disease yet feel very poorly on a gluten containing diet. So, these would be the non-celiac gluten sensitivity patients. And, you know, it is a very poorly defined disease but yet, it’s there. There is some evidence to suggest that there may be a little bit of inflammation in these folks as well but we’re very early on in our research in that aspect. You know, all three of these conditions have overlapping features, which is why it can be confusing. So, with the fad diet - of a gluten free diet - it’s, I think, both a good and a bad thing. I love that it allows my celiac patients to have more possibilities, especially going out to eat. Many restaurants offer a gluten free diet now and I think that’s great because before, patients were stuck with very little to eat. They would have to cook at home, stick to maybe like a tiny little space within the grocery store where the gluten free stuff was. But now, you know, the possibilities are much more. However, having said that, because it is a bit of a fad, I think some people tend to maybe roll their eyes at it and say, ‘Oh well, you know, you don’t really have some allergy or sensitivity or whatever, you’re just following this fad diet.’ And so, the danger in that would be that maybe like a restaurant person would not take it as seriously and not take into account the cross contamination that’s possible. I mean, some people with celiac disease really just take that one exposure and they can, you know, throw them into their symptoms. So, it’s both a good and a bad thing. But, again, it’s important, you know, from patient to patient like, to know what it is that you have and what is potentially life threatening and what is not. I just want to bring up another point and that to test positive for celiac disease, you have to be on gluten at the time. So, you have to be eating gluten and so you’re therefore not feeling well, but you need to have that exposure in order for us to pick it up on our testing. Host: You mentioned that there are three main conditions. Could you give us a small recap of each of them? Dr. Lee: Sure. Well, there’s celiac disease and that, we’ve spoken about, it’s in genetically susceptible individuals. They have this proven inflammation in their small intestine resulting in a gamut of symptoms. There’s wheat allergy and that is your typical ‘quote/unquote’ food allergy where you, you know, can potentially get anaphylaxis to it. And then there’s non-celiac gluten sensitivity and that’s the very poorly defined one. But, again, there can be a lot of common symptoms. But, I think that, based on my patients, what I usually hear, is the abdominal pain, the fatigue, and the brain fog. Those are three of the very common ones for gluten sensitivity. Host: Are there any health benefits for going gluten free for people that don’t have a gluten sensitivity or celiac disease? Dr. Lee: That’s a good question and I think it’s going to be a bit of a complex answer. When people tend to take out gluten they do take out a lot of carbs and so, you know, limiting your carb intake can be healthy. But what are you replacing that with? Are you replacing it with, you know, a bread that you’re buying in the gluten free aisle, in which case, that’s actually a heavily processed food item. It can be very high in calories and so it makes a difference what you’re replacing that food with. One thing we do need to think about though is, are there any consequences of going on a gluten free diet. And the answer to that is potentially yes. We do have some studies showing that there can be nutrient or/and micronutrient and vitamin deficiencies, you know, even ten years down the road. And these are based on our celiac patients, but we think it’s due to them being on a gluten free diet for a long period of time. We’ve seen some data showing that patients who have been on a gluten free diet for a prolonged period of time are more obese than patients who have not been on a gluten free diet. And then not to mention the cost. You know, it’s very...it’s not cheap buying the foods from the gluten free section. Host: I’ve noticed that a lot in grocery stores, it seems like any kind of health product seems to be more expensive than the assumed not healthy product. Dr. Lee: And I think part of that is a little bit of marketing preying on consumers. If you’re in the shampoo aisle and you see a shampoo labeled gluten free and it’s three times the price of regular shampoo, people don’t necessarily know that. They just think that gluten is bad, and they may buy the shampoo that’s gluten free, but really that makes no difference. There was one small study suggesting that in adults who follow a gluten free diet, they may be at risk for cardiovascular complications because, the thought process was that they were consuming less whole wheat. But again, very early on in our research regarding this. You know, the most scientific way to go about it would be to remove gluten from your diet and then you’ll notice that you feel better. And when you reintroduce gluten, do it in a blinded fashion. Then introduce something that you may or may not know whether it has gluten or not and see how you feel. Maybe your friend knows, maybe your friend knows which bread is the, you know, gluten free bread and which one’s the regular bread. But, I think mostly, it’s how you feel - how you feel on it, how you feel off of it. Host: Thanks for joining us today, Dr. Lee. Dr. Lee: Oh, you’re very welcome. Thanks for having me. Conclusion: Thanks for listening to Medical Intel with MedStar Washington Hospital Center. Find more podcasts from our healthcare team by visiting medstarwashington.org/podcast or subscribing in iTunes or iHeartRadio.