Podcasts about Phase

On today's episode, Dr. Mark Costes welcomes back tax and accounting experts Brent Sonnier and Chris Sands from ProFi 2020 and Phase 1 Financial to tackle some of dentistry's most advanced and impactful tax strategies. Whether you're preparing for a major liquidity event, trying to reduce your W-2 tax liability, or just looking to be more strategic with your investments, this episode is packed with high-level insights.   The trio covers bonus depreciation, the mechanics and timing of cost segregation, oil and gas investments, R&D tax credits, and the true pros and cons of short-term rentals. Mark also shares some personal experiences—both wins and hard lessons—from navigating these strategies in his own portfolio. This conversation is a must-listen for any dentist serious about long-term wealth building and minimizing tax exposure in a legal and strategic way.   Be sure to check out the full episode from the Dentalpreneur Podcast! EPISODE RESOURCES https://www.profi2020.com https://www.truedentalsuccess.com Dental Success Network Subscribe to The Dentalpreneur Podcast

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This clip is an excerpt from the episode "Triathlon Base Training Series 5 - Strength Training, Nutrition & Diet, and Listener Q&A" (release date 8th of January 2026). TOPICS COVERED IN THIS CLIP: The importance of strength training for injury prevention and managementCommon misconceptions (stretching vs. strength training)Periodisation of strength trainingTypical session frequency and durationTiming of sessions within the overall training programManaging soreness and integrating strength training with sport-specific trainingLEARN MORE ABOUT SCIENTIFIC TRIATHLON: The Scientific Triathlon website is the home of That Triathlon Show and everything else that we doContact us through our contact form or email me directly (note - email/contact form messages get responded to much more quickly than Instagram DMs)Subscribe to our NewsletterFollow us on InstagramLearn more about our coaching, training plans, and training camps. We have something to offer for everybody from beginners to professionals. HOW CAN I SUPPORT THAT TRIATHLON SHOW (FOR FREE)? I really appreciate you reading this and considering helping the show! If you love the show and want to support it to help ensure it sticks around, there are a few very simple things you can do, at no cost other than a minute of your time. Subscribe to the podcast in your podcast app to automatically get all new episodes as they are released.Tell your friends, internet and social media friends, acquaintances and triathlon frenemies about the podcast. Word of mouth is the best way to grow the podcast by far! Rate and review the podcast (ideally five stars of course!) in your podcast app of choice (Spotify and Apple Podcasts are the biggest and most important ones).Share episodes online and on social media. Share your favourite episodes in your Instagram stories, start a discussion about interesting episodes on forums, reference them in your blog or Substack. NordVPN - EXCLUSIVE NordVPN Deal ➼ https://nordvpn.com/TRIATHLONTry it risk-free now with a 30-day money-back guarantee Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

This episode opens the year with one of the most consequential—and complicated—weeks in GLP-1 obesity medicine. We break down three stories that, taken together, reveal why patients are increasingly reading past headlines and demanding accountability from the industry. First, we examine early-phase trial data from Arrowhead Pharmaceuticals, after headlines claimed its experimental INHBE-targeting therapy “nearly doubled” the weight loss of Zepbound. We walk through what the data actually showed, why the comparison was misleading, how trial design and dosing matter, and why Phase 1 results should never be treated as superiority claims. Next, we turn to a major access milestone: the official launch of oral Wegovy, the first FDA-approved GLP-1 pill for obesity from Novo Nordisk. We discuss how this pill differs from compounded oral semaglutide, why its pricing strategy is so disruptive, and what this launch means for people who have avoided injectable medications. We also explore how direct-to-consumer access, telehealth partnerships, and retail pharmacy distribution signal a broader shift in how obesity care is being delivered. Finally, we address the most ironic—and uncomfortable—story of the week: manufacturing quality concerns involving branded Wegovy pens, reported to include biological particulate matter, at the same time Novo Nordisk continues a years-long public and legal campaign against compounded GLP-1 medications on safety grounds. We discuss FDA inspection history, the acquisition of Catalent, and why credibility depends on consistency—especially when millions of patients are paying close attention. This episode isn't anti-pharma or pharma-friendly. It's patient-first. And it asks a simple question: Who do we trust when science, marketing, access, and manufacturing all collide at once? Episode Timestamps 00:00 — Why this first episode of 2026 matters 02:10 — Hair found in Wegovy pens and why patients notice hypocrisy 06:15 — Arrowhead trial headlines vs. what the data actually shows 11:40 — Why tirzepatide dosing and trial design matter 17:30 — What INHBE targeting may actually be good for (and what it's not) 21:45 — Sponsor: SHED and access pathways for obesity care 25:10 — Oral Wegovy officially launches: what's different this time 30:20 — How the Wegovy pill works and why bioavailability matters 35:40 — Pricing, telehealth, Costco, and direct-to-consumer access 41:50 — Why pills lower barriers for millions of patients 46:10 — Manufacturing quality, Catalent, and FDA citations 52:30 — Why safety arguments against compounding are being scrutinized 58:40 — Zooming out: access, accountability, and patient trust 1:02:00 — Final thoughts and what to watch next Topics Covered GLP-1 trial hype vs. real-world context Phase 1 data limitations and headline inflation Tirzepatide dosing and misleading comparisons Oral Wegovy vs. compounded oral semaglutide GLP-1 pill pricing and insurance implications Direct-to-consumer pharma and telehealth disruption Manufacturing quality and FDA oversight Compounding pharmacies and healthcare system resilience Patient trust, transparency, and credibility in obesity medicine Useful Links & Resources On The Pen Links & Advocacy: https://otplinks.com Sponsor – SHED (use code OTP25): https://tryshed.com FDA Drug Safety & Recalls: https://www.fda.gov/drugs Follow On The Pen: YouTube: https://youtube.com/@onthepen Substack: https://onthepen.substack.com Support the Show If this episode helped you better understand what's really happening in obesity medicine: Leave a 5-star rating and review Hit Subscribe so you don't miss future episodes Join us live Mondays, Wednesdays, and Fridays at 12pm Eastern on YouTube Patients deserve clarity. That's what we're here for. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Middle schoolers can be argumentative. And it can drive parents crazy. But they are blossoming into young adults who will need to communicate and sometimes argue ideas in the real world soon enough. How do we equip them with the tools to not only think through their own beliefs, but to critically process new ideas, and sift through arguments to find and promote TRUTH above all?Enter the LOGIC phase of classical Christian education - the middle segment of our three-pronged Trivium. Right in the center of their education, students train their minds to know how to spot and construct sound, valid arguments and reason well, so that they can apply the facts they've learned and live as someone who listens and speaks well.In this episode, we'll hear from our two Logic teachers at Veritas Academy - Stephen Darrenkamp (who also teaches Latin) and Adam Timmins (who also teaches Omnibus and Apologetics). You'll listen in on a discussion covering:The role of logic in a student's educationThe integration with faith and reasonHow logic prepares students for rhetoric and effective communicationPractical advice for parents of argumentative middle schoolersThe broader implications of logic on students' understanding of faith, culture, and morality.

At CES 2026 yesterday, Sony and Honda revealed using crypto technology for its future electric vehicles, planning an on-chain, token-based platform where users earn rewards for participation. Meanwhile the Japanese government is gearing up to to unleash a multi-year long plan to bring crypto adoption into the mainstream using gaming.Guest: Yat Siu - Co-Founder & Chairman, Animoca Brands Animoca Brands website ➜ https://www.animocabrands.com/Follow Yat Siu ➜ https://x.com/ysiu00:00 intro00:09 Crypto Trends00:38 Japan Goes All-In on Crypto01:30 Stablecoins & Stocks Coming02:00 Yat Siu02:20 Sony x Honda Announce Crypto Platform03:18 Self-Driving Crypto Cars05:50 Phase of Hidden Blockchain Features06:46 XREAL Asus Glasses Revealed07:48 Sexy Handheld Gaming08:20 Gaming is a tech driver09:00 AR is now a better experience?10:25 GTA 6 Coming10:52 Japan Crypto Strategy15:38 Bullish 2026 Outlook17:18 Sega "SUPER GAME" in 202618:41 What blockchains will they use?21:26 Sony Japan = Worlds biggest Casino?24:47 Pokémon Announcement Coming in February27:21 Animoca Brands IPO in U.S.28:04 Altcoins Will Outperform Bitcoin28:57 $CURR Marketcap Explained30:28 Best Asian Crypto Company To Invest In31:59 Low Cap Utility Tokens34:58 Animoca = Best Retail Stock for altcoins?35:42 Gaming tokens will surprise everyone in 202638:43 Tom Lee merging with Japan's ETH Treasury?41:22 outro#Crypto #Ethereum #Bitcoin~Japan's Multi-BILLION $ Crypto Master Plan in 2026!♟️Yat Siu ANIMOCA BRANDS

For over 4,000 years, silkworms have connected civilizations through ancient trade routes. Now, KAICO Ltd., a Japanese biotech spin-off from Kyushu University, is transforming these creatures into living bioreactors capable of producing complex recombinant proteins and vaccine antigens—without the bioreactors, expensive media, or massive water consumption of conventional platforms.Masafumi Osawa, Business Development Lead at KAICO, brings an unconventional path to biotech. Trained in cultural anthropology with fieldwork experience in Indonesia, he witnessed firsthand the healthcare disparities that drive his current mission. After years in pharmaceutical business development at Towa Pharmaceutical, he joined KAICO to help scale a technology he believes could reshape global vaccine accessibility. His cross-cultural expertise now proves invaluable as KAICO expands internationally, with active partnerships in Vietnam and Thailand and growing interest from other regions.Episode highlights:Masafumi's transition from anthropology to biotech, and how cross-cultural expertise benefits global health collaborations. (04:15)The founding story of KAICO, spun out from Kyushu University and focused on recombinant proteins and vaccine antigen production (08:45)Step-by-step overview of the silkworm baculovirus expression system, including pupae handling and bioprocessing basics. (10:28)Practical differences between silkworms, E. coli, mammalian, and insect cell culture platforms—exploring advantages and drawbacks. (13:10)Strategies KAICO uses to control silkworm variability, including SPF grade sourcing, diet, environment, and documentation for pharmaceutical acceptance. (15:08)Production scalability: a single pupa can match 100–1000 ml of insect cell culture, with major implications for cost and environmental footprint. (16:42)Downstream harvesting and purification—how KAICO extracts and processes proteins from silkworm pupae, keeping methods largely familiar to traditional systems. (19:31)Regulatory and GMP challenges of using live organisms, and KAICO's approach to satisfying authorities and ensuring product consistency. (21:43)Whether you're curious about alternative biomanufacturing methods or want a transparent look at silkworm-based protein expression from research to the clinic, this episode delivers practical insights and thoughtful discussion.Connect with Masafumi Osawa:LinkedIn: www.linkedin.com/in/masa-osawaKAICO Ltd.: www.kaicoltd.jp/enNext step:Need fast CMC guidance? → Get rapid CMC decision support hereOne bad CDMO decision can cost you two years and your Series A. If you're navigating tech transfer, CDMO selection, or IND prep, let's talk before it gets expensive. Two slots open this month.Support the show

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-Rob kicks off the year by celebrating Maduro's capture like it's the Super Bowl… except the halftime show is a special forces raid and the confetti is Democrats yelling “THIS IS BAD ACTUALLY.” -Newsmax contributor Katie Zacharia jumps in to celebrate Freedom 250, gush over the Washington Monument light show, and tag-team with Rob in predicting that 2026 is the greatest year for America since 1776. -Brigadier General (Ret.) Blaine Holt joins the show and happily announces he's “Maduro-free and loving it,” geeks out over the perfection of the special ops mission, and casually mentions that hostile regimes everywhere are now checking Zillow in Moscow. Today's podcast is sponsored by : RELIEF FACTOR - You don't need to live with aches & pains! Reduce muscle & joint inflammation and live a pain-free life by visiting http://ReliefFactor.com now!  BEAM DREAM POWDER - Refreshing sleep now 40% off with promo code NEWSMAX at http://shopbeam.com/newsmax BIRCH GOLD - Protect and grow your retirement savings with gold. Text ROB to 98 98 98 for your FREE information kit! To call in and speak with Rob Carson live on the show, dial 1-800-922-6680 between the hours of 12 Noon and 3:00 pm Eastern Time Monday through Friday…E-mail Rob Carson at : RobCarsonShow@gmail.com Musical parodies provided by Jim Gossett (http://patreon.com/JimGossettComedy) Listen to Newsmax LIVE and see our entire podcast lineup at http://Newsmax.com/Listen Make the switch to NEWSMAX today! Get your 15 day free trial of NEWSMAX+ at http://NewsmaxPlus.com Looking for NEWSMAX caps, tees, mugs & more? Check out the Newsmax merchandise shop at : http://nws.mx/shop Follow NEWSMAX on Social Media:  -Facebook: http://nws.mx/FB  -X/Twitter: http://nws.mx/twitter -Instagram: http://nws.mx/IG -YouTube: https://youtube.com/NewsmaxTV -Rumble: https://rumble.com/c/NewsmaxTV -TRUTH Social: https://truthsocial.com/@NEWSMAX -GETTR: https://gettr.com/user/newsmax -Threads: http://threads.net/@NEWSMAX  -Telegram: http://t.me/newsmax  -BlueSky: https://bsky.app/profile/newsmax.com -Parler: http://app.parler.com/newsmax Learn more about your ad choices. Visit megaphone.fm/adchoices

Scientists are expanding our understanding of MS at an unprecedented pace. This week, Dr. Leorah Freeman discusses why, as new discoveries and medications enter clinical practice, neurologists and MS specialists should ask themselves 3 important questions when considering a patient's treatment plan. Dr. Freeman is the Director of the Multiple Sclerosis and Neuroimmunology Center at Dell Medical School at the University of Texas at Austin, where she also leads the MS and Neuroimmunology fellowship program and the MS Imaging and Outcomes Research Laboratory.  We'll also tell you about study results that reveal two distinct biologically-informed MS subtypes. We're explaining some of the confusing background to the FDA's decision not to approve a disease-modifying therapy that achieved positive results in its Phase 3 clinical trial. And did we really need a study to tell us that people living with MS fear experiencing a relapse or disease progression? Well, yes. We'll explain why. We're also reminding you to mail your insurance premium payments and other important documents earlier than you have in the past.  And we're sharing details about the two clinical trials that received $4.1 million in funding as part of the International Progressive MS Alliance Experimental Medicine Trial Awards. We have a lot to talk about! Are you ready for RealTalk MS??! This Week: 3 questions your neurologist should be asking themselves  :22 Public Service Announcement: How the new rule about postmarks could affect your healthcare  1:16 FDA says it's not ready to approve Tolebrutinib  3:16 Study identifies two biologically-informed MS subtypes  6:29 Study results remind us that people with MS fear relapse and progression  10:09 The International Progressive MS Alliance invests $4.1 million in two clinical trials  14:04 Dr. Leorah Freeman discusses why neurologists need to ask themselves 3 important questions when considering a patient's treatment plan  17:18 Share this episode  33:16 SHARE THIS EPISODE OF REALTALK MS Just copy this link & paste it into your text or email: https://realtalkms.com/436 ADD YOUR VOICE TO THE CONVERSATION I've always thought about the RealTalk MS podcast as a conversation. And this is your opportunity to join the conversation by sharing your feedback, questions, and suggestions for topics that we can discuss in future podcast episodes. Please shoot me an email or call the RealTalk MS Listener Hotline and share your thoughts! Email: jon@realtalkms.com Phone: (310) 526-2283 And don't forget to join us in the RealTalk MS Facebook group! LINKS If your podcast app doesn't allow you to click on these links, you'll find them in the show notes in the RealTalk MS app or at www.RealTalkMS.com The Multiple Sclerosis Insider https://themultiplesclerosisinsider.substack.com STUDY: Combined Magnetic Resonance Imaging and Serum Analysis Reveals Distinct Multiple Sclerosis Types https://academic.oup.com/brain/article/148/12/4578/8321558 STUDY: Fear of Disease Progression and Relapse in Multiple Sclerosis: A Systematic Scoping Review https://frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1680781/full JOIN: The RealTalk MS Facebook Group https://facebook.com/groups/realtalkms REVIEW: Give RealTalk MS a rating and review http://www.realtalkms.com/review Follow RealTalk MS on Twitter, @RealTalkMS_jon, and subscribe to our newsletter at our website, RealTalkMS.com. RealTalk MS Episode 436 Guests: Dr. Leorah Freeman Privacy Policy

Markets wrapped up the year with solid gains, finishing roughly 17% higher, but momentum has cooled as stocks consolidate near recent highs. Despite briefly setting a new all-time high in late December, markets spent the final weeks of the year moving sideways, reflecting growing fatigue after an extended rally. In this pre-market update, we review why the market's two-month consolidation range matters, how staying above the 20-day moving average supports the broader trend, and why recent momentum sell signals do not necessarily signal a major downturn. With markets up eight consecutive months, short-term pullbacks or mild corrections would be a normal and healthy way to relieve overbought conditions. As traders return for the first full week of the new year, futures are pointing higher—but volatility may increase as we move into the first quarter. We discuss what investors should watch in January and February, how to think about near-term weakness, and why disciplined risk management remains critical after a long run of gains. Hosted by RIA Chief Investment Strategist, Lance Roberts, CIO Produced by Brent Clanton, Executive Producer ------- Watch the Video version of this report on our YouTube channel: https://www.youtube.com/watch?v=ZeEA-JQBKEA&list=PLwNgo56zE4RAbkqxgdj-8GOvjZTp9_Zlz&index=1 ------- Articles mentioned in this report: 2026 Market Outlook Based On Valuations https://realinvestmentadvice.com/resources/blog/2026-market-outlook-based-on-valuations/ "Fed's Soft Landing Narrative Meets Economic Data" https://realinvestmentadvice.com/resources/blog/feds-soft-landing-narrative-meets-economic-data/ ------- REGISTER for our 2026 Economic Summit, "The Future of Digital Assets, Artificial Intelligence, and Investing:" https://www.eventbrite.com/e/2026-ria-economic-summit-tickets-1765951641899?aff=oddtdtcreator ------- Get more info & commentary: https://realinvestmentadvice.com/insights/real-investment-daily/ ------- Visit our Site: https://www.realinvestmentadvice.com Contact Us: 1-855-RIA-PLAN -------- Subscribe to SimpleVisor: https://www.simplevisor.com/register-new -------- Connect with us on social: https://twitter.com/RealInvAdvice https://twitter.com/LanceRoberts https://www.facebook.com/RealInvestmentAdvice/ https://www.linkedin.com/in/realinvestmentadvice/ #MarketOutlook #StockMarketUpdate #MarketVolatility #TechnicalAnalysis #PreMarketUpdate

The Road to Doomsday continues as Jarod and Taylore reach Phase 3 with Captain America: Civil War bringing our hosts to a conflict of their own over the infamous Sokovia Accords. Sunday's Bloody Mary: https://sundaysbloodymary.com/shop/ Luminous Odyssey:https://www.youtube.com/c/AllRemainingSystems Mitch692 Channel: https://www.youtube.com/@TheMitch692Channel Help us out by chuckin' a buck on our Patreon: https://www.patreon.com/thenerdacademypodcast

Happy New Year Everyone!In this episode I unpack why healthy male power is actually a force for good in the world and why the true danger lies in powerlessness.I trace how unacknowledged boys can grow into passive or angry men and I talk about the three most important ways that a young boy finds his healthy power as he grows up.Listen in to learn about the differences between male and female power, why being of service in the world is impossible without power, the difference between power and force, and so much more.TIMESTAMPS:00:00 — Intro: Power & Male Happiness 01:05 — Client Wins: Vision & Success 02:46 — The Healer's Story: Releasing Trauma 03:38 — The Spectrum of Powerlessness: Rage vs. Passivity 05:37 — The "Nice Guy" & People Pleasing 06:41 — Defining True Power vs. Force 08:23 — The Extreme Consequence of Isolation 10:51 — Phase 1: Affirmation from Mother 12:52 — The Trap of the "Mother's Son" 14:37 — Phase 2: The Father's Nod of Approval 16:08 — Phase 3: Self-Mastery & Purpose 17:45 — The Impact of a Critical Father 18:44 — Three Traits of an Attractive Man 20:54 — Releasing Trauma from the Body 22:21 — Female Power: Devotion to Love 24:07 — Attraction: Male Power & Female Devotion 25:39 — Balancing Internal & External Worlds 27:07 — Mastermind Announcement 28:33 — New Year Wishes30:09 — Outro___________________________If you found some value today then help me spread the word! Share this episode with a friend or leave a review. This helps the podcast grow.You can also watch the episodes on youtube hereFollow me on Instagram @anyashakhYou can book a discovery call at https://anyashakh.com/mentorship

In Episode 1, I revealed the clues hidden in my labs — the WHY behind my fatigue, slower recovery, reduced power output, dry skin, and metabolic slowdown. Now in Part 3 & Part 4 of my personal case study, we turn insight into ACTION. You'll learn: The ROOT-CAUSE MAP of my body • Low ATP from microbiome imbalance • Fat malabsorption choking metabolism • LPS/endotoxin stress suppressing fat burning • High cortisol blocking thyroid activation • Oxidative stress damaging mitochondria • Genetic vulnerabilities amplifying the effect How this showed up in real life • Running performance dropping • Heart rate spikes in Zone 2 • Needing more fuel on long efforts • Harder time building + maintaining muscle • Skin + hormone changes • Mood and motivation shifts The 4-Phase FutureYou Blueprint™ Plan I built for myself PHASE 1 — Digest • Absorb • Drain PHASE 2 — Kill • Clear • Rebuild PHASE 3 — Mitochondria + Muscle Reboot PHASE 4 — Longevity Optimization I walk you through the WHY behind every tool, including: • TUDCA • Tributyrin (butyrate) • S. boulardii • Phosphatidylcholine • Creatine, CoQ10, PQQ, DHA • Nervous system support • HBOT, sauna, cold exposure This is exactly how I help clients transform from burned-out and metabolically stuck → to energized, strong, and aging powerfully. If you're ready to create your own FutureYou Blueprint™, this episode will show you what's possible when you finally stop guessing — and start investigating.

There is a phase of spiritual awakening where nothing feels wrong, yet nothing feels clear. Your old life no longer fits, guidance feels quieter, and the new hasn't fully landed yet.In this episode, I talk about the overlooked integration phase of awakening and why this disorientation occurs. Understanding what's happening can help you move through this phase with more trust, stability, and patience. This quiet phase is part of how clarity and embodiment return.

Family of Taygeta Podcast: Akatu - The Healing Phase From Sheen UNCODE.initRow(document.getElementById("row-unique-0"));

HUGE ANNOUNCEMENT! We are officially relaunching the Say Yes Anyway podcast with fresh new branding, colors, and all the things! Follow us on Instagram @sayyesanywaypodcast_Download your FREE Envision Your Vision workbook:DM me on Instagram: @jessdahl_Email: jess@jessdahl.comWebsite: jessdahl.comThis is for anybody that wants to go into the new year fresh and new. It doesn't matter where you are—whether you're in momentum riding a rocket ship or feeling stuck with no idea what you want with your life. The good news? You can start today. You don't have to wait for tomorrow or next year.In this episode, I'm sharing:My real-time story of finding our dream home in Santa Barbara - how holding down a vision while taking massive action led Char and me to the perfect place just days before our January 1st move-in dateThe 4-Phase Envision Your Vision Process - the exact framework I've used for years to transform my life and that I teach my clients, team, and communityPhase 1: Monthly Inventory & Reflection - how going through every month of 2025 revealed the fullness of my life, even through $25,000 in medical debt and physical pain from a car accidentPhase 2: Deep Reflection Questions - why most people are afraid of stillness and how getting still changed everything for me (plus the 3 pages of questions that will help you gain clarity)Phase 3: Letting Go - what habits, beliefs, people, and things I'm releasing in 2026, including hard realizations about friendships and what I actually value in relationshipsPhase 4: Calling In 2026 - why I don't believe in New Year's resolutions and what actually works instead (hint: it's about becoming the person, not just doing the things)My 3 Intention Words for 2026 - EXPANSION, CHILDLIKE, and MEMORIES, and how I use these daily to guide my decisions and actionsThe power of allowing yourself to dream - from rocket ship big dreams to day-to-day adventures like dancing with Char anytime, anywhereThis episode is packed with real stories, practical wisdom, and actionable steps to help you start 2026 with clarity, courage, and intention.Where you can find me:Instagram: https://www.instagram.com/jessdahl_/Website: https://www.jessdahl.comEmail: jess@jessdahl.comPodcast Instagram: https://www.instagram.com/sayyesanywaypodcast_/Upcoming Opportunities:6th Camino Retreat - May 2026 (DM me for details!)Couples Wholeness Journey (epic surprises coming soon)Vision Board Event (details coming)It would mean the world if you can share this episode with a friend who's ready to step into the new year with intention and clarity. One brave YES can change everything.If you're interested in doing the Envision Your Vision workbook with me or want to talk about coaching, get in contact with me and let's see if it's an aligned fit.If you liked it, share it with a friend or on social media and tag @jessdahl_ and @sayyesanywaypodcast_Leave us a review because it helps so much, especially now that we're relaunching the Say Yes Anyway podcast. I love you guys. Thank you. See you at the next one.

Massive protests have broken out in Iran as the economy there implodes. This is no longer an uncommon occurrence as we're seeing more signs of the most dangerous phase of the economy. Spurred largely by younger generations who have born the brunt of economic suckitude their entire lives, political upheaval is spreading and intensifying – maybe presenting opportunity but either way it is, by far, the greatest risk the world faces in 2026.Eurodollar University's Money & Macro Analysis------------------------------------------------------------------------------EDU LIVE PRESIDENT'S DAY FEBRUARY 2026If you're a serious investor and want to capitalize on what the monetary system is signaling right now, plus deep discussions about what truly is the greatest threat we all face, join me, Hugh Hendry, George Gammon, Steve Van Metre, Brent Johnson, Mike Green at Eurodollar University's very first Live Event, President's Day Weekend February 2026. To reserve your spot just go here but you better hurry, there aren't many spots left:https://eurodollar-university.com/event-home-page---------------------------------------------------------------------------------Bloomberg Gen Z Revolts Against Dystopian Future as Protests Spread Worldwidehttps://www.bloomberg.com/features/2025-gen-z-protest-worldwide/Gallup George H.W. Bush Retrospectivehttps://news.gallup.com/opinion/gallup/234971/george-bush-retrospective.aspxCSpan October 1992 Presidential Townhallhttps://www.c-span.org/clip/white-house-event/user-clip-clintons-i-feel-your-pain-moment/4842764https://www.eurodollar.universityTwitter: https://twitter.com/JeffSnider_EDU

1 / 4 MDJ Script/ Top Stories for December 31st Publish Date: December 31st Commercial: From the BG Ad Group Studio, Welcome to the Marietta Daily Journal Podcast. Today is Wednesday, December 31st and Happy Birthday to Donna Summer I’m Keith Ippolito and here are the stories Cobb is talking about, presented by Times Journal 1. ‘Bittersweet’ goodbye: Marietta school board says farewell to three colleagues 2. New Cobb Young Republicans Chair looks to affordability, voter engagement 3. Cumberland CID details big projects, future plans All of this and more is coming up on the Marietta Daily Journal Podcast, and if you are looking for community news, we encourage you to listen and subscribe! BREAK: INGLES 1 STORY 1: ‘Bittersweet’ goodbye: Marietta school board says farewell to three colleagues The final meeting of the year for the Marietta Board of Education was a bittersweet one, full of hugs, tears, and heartfelt goodbyes as three longtime members—A.B. Almy, Kerry Minervini, and Jason Waters—stepped down. During the meeting, emotions ran high. Vice Chair Jaillene Hunter praised Almy for her relentless push for academic excellence. Angela Orange called Minervini “a woman who gives a million percent,” while Irene Berens, tearing up, described Waters as “an exceptional man and a dear friend.” Waters, who’s moving on to the Marietta City Council, called the moment “surreal.” Minervini, meanwhile, joked about finding a new hobby, and Almy expressed gratitude for her time on the board. The night ended with a video tribute, glass plaques, and a reminder of the board’s legacy: being named Georgia’s 2025 School Board of the Year. STORY 2: New Cobb Young Republicans Chair looks to affordability, voter engagement At just 25, Andre Stafford is stepping up as the new chairman of the Cobb Young Republicans, ready to shake things up. “I’m all in,” he says, a mantra that’s driven him since he first got involved in politics after the 2024 assassination attempt on Donald Trump—a moment that, for him, changed everything. Stafford, a restaurant manager by day, wants to grow the group, boost voter turnout, and focus on issues like affordability. “The American Dream feels like a fairy tale to my generation,” he says. “We need more homeowners, less paycheck-to-paycheck living.” His goal? Turn Cobb red—and keep it that way. STORY 3: Cumberland CID details big projects, future plans 2 / 4 Big things are happening in Cumberland, and Kim Menefee, the CID’s executive director, couldn’t be prouder. “2025 was our best year yet,” she told lawmakers at a recent meeting. One highlight? The first phase of the New Day Palisades project at Paces Mill Park. With $6.3 million in upgrades—like better parking, trail access, and erosion control—it’s already drawing millions of visitors. Phase 2 kicks off in 2026, with a $9.5 million price tag and plans for a visitor center and river overlooks. Oh, and driverless shuttles? Coming in 2027. Free rides connecting The Battery, Truist Park, and more. Cumberland’s future? Bold. We have opportunities for sponsors to get great engagement on these shows. Call 770.799.6810 for more info. We’ll be right back. Break: INGLES 1 STORY 4: Cobb Superior Court Clerk asks judge to dismiss charges against her Lawyers for Cobb Superior Court Clerk Connie Taylor are fighting to get her case dismissed before it even reaches trial. Meanwhile, prosecutors are busy filing motions over what evidence can and can’t be shown in court. Taylor, elected in 2020, faces four felony charges tied to allegations she mishandled passport fee records—pocketing over $425,000 in fees during her first two years in office. Things escalated when a whistleblower claimed Taylor ordered records destroyed, reportedly saying, “We’re just going to Donald Trump this thing.” Taylor denies wrongdoing, but if convicted, she’ll lose her job permanently. A hearing is set for Feb. 5. STORY 5: Marietta residents call for increased safety measures after crash on train tracks Residents are sounding the alarm after a truck barreled off the road and crashed near the train tracks at Kennesaw Avenue and Church Street last week. Melissa Korczyk, out for a walk with her toddler and dog, heard the screech of tires just before 10 a.m. “I look up, and this car is flying down Kennesaw Avenue,” she said. “It hit the tracks, went airborne, and slammed into the pedestrian signal.” The driver, who also hit a light post and tree, escaped with minor injuries and was charged with reckless driving. “It’s scary,” Korczyk said. “That intersection feels like an accident waiting to happen.” Break: 3 / 4 STORY 6: Marietta celebrates legacy of service as three council members retire The Marietta Fire Museum was full of laughter, hugs, and a few teary eyes last week as friends, family, and city staff gathered to honor retiring council members Andy Morris, Grif Chalfant, and Johnny Walker. “You’ve left a footprint on this city that just keeps getting better,” said Mayor Steve “Thunder” Tumlin, summing up the mood of the night. Chalfant, who’s been on the council since 2005, joked about finally tackling 20 years of neglected home projects—and maybe fixing up his Triumph TR3. Morris, a lifelong Marietta resident, said he’s ready to relax with his new dog, Harry. “I might even pick up golf again,” he added. Walker, proud of his work on school traffic safety, plans to focus on real estate, photography, and more time at home. Each was presented with a Distinguished Service Award, a fitting send-off for years of dedication. STORY 7: Baby clothes program helps mothers in need year-round For nearly two decades, Rosemary Buckley has quietly made life a little easier for new moms in need. Every month, she gathers bundles of baby clothes—layettes—and delivers them to Wellstar Kennestone, where they’re given to families who could use a little extra help. “It’s not just store-bought stuff,” Buckley says. “Parishioners make blankets, tiny hats, even mittens. It’s beautiful.” Inspired by her 12 grandchildren and a simple church request back in 2007, Buckley has turned this into her mission. Monsignor John Walsh calls her a “woman of action.” She just calls it “something that needs to be done.” We’ll have closing comments after this. Break: INGLES 1 Signoff- Thanks again for hanging out with us on today’s Marietta Daily Journal Podcast. If you enjoy these shows, we encourage you to check out our other offerings, like the Cherokee Tribune Ledger Podcast, the Marietta Daily Journal, or the Community Podcast for Rockdale Newton and Morgan Counties. Read more about all our stories and get other great content at www.mdjonline.com 4 / 4 Did you know over 50% of Americans listen to podcasts weekly? Giving you important news about our community and telling great stories are what we do. Make sure you join us for our next episode and be sure to share this podcast on social media with your friends and family. Add us to your Alexa Flash Briefing or your Google Home Briefing and be sure to like, follow, and subscribe wherever you get your podcasts. Produced by the BG Podcast Network Show Sponsors: ● www.ingles-markets.comSee omnystudio.com/listener for privacy information.

Phase Into Fasting // Phil Thompson // PF Campus by The Heart

Johns Hopkins University、Neuroscience PhD Candidateの末岡陽太朗さんゲスト回。今年出た1つ目のPhDメイン仕事、theta precession、JHUやMITでの学生生活、など。 (2025/12/14 収録)Show Notes (番組HP):末岡陽太朗さん今回出版されたPhD1つ目の仕事: Sueoka et al., 2025Jim KnierimNoah Cowan最初のドーム論文: Jayakumar et al., 2019O'Keefe and Recce, 1993Phase coding（位相コーディング）theta precessionがsequenceの源になってるんじゃないかとSkaggsが1996年に予測した: Skaggs et al., 1996Sequenceを実際に証明: Foster and Wilson, 2007; Johnson and Redish, 2007Skaggsの話をした雑談回: #101前半と後半が2つのガウシアンになっている: Yamaguchi et al., 2002 Mike Hasselmoが2002に提唱したモデル: Hasselmo et al., 2002「Phase preferenceを見ると大体前半半分にでかいピークがある。後半の残り180度~」: ここでいう前半はplace fieldの前半に対応するとされているtheta phase (late phase）であることに注意。「後半」はplace fieldの後半（thetaのearly phase)を指している。（末）(place fieldでいう後半に）発火しているときは、'pro'cessionになっている: Wang et al. 2020Grid cellのtheta precession: Haftig et al. 2008Dragoi and Buzsáki 2006Giocomo labの論文: Campbell et al. 2018Schmidt, Diba, et al. 2009Circular linear regressionのメソッド論文: Kempter et al. 2012Chu et al. 2024 Jensen and Lisman, 1996SawtellラボEigenmaniaMossラボモナコ論文: Monaco et al. 2014昔のネイチャーでうちの猫の爪かなんかの...:  猫の歯でした笑（藤）Vivek JayaramanRachel Wilson安田先生生物学オリンピック(金メダル!)AFS哲学オリンピックBertrand RussellMichale FeeEmery BrownMatt WilsonDragonForce のギタリストは香港系の方だったんですね…。結局、自分も他文化への理解が浅いことを改めて反省…。（藤）FedorenkoラボJeremiah CohenKishore KuchibhotlaICの論文Noam ChomskyNatural NeuroscienceArseny Finkelsteinの最近出た論文: Finkelstein et al. 2025Burgalossi labの最近出た論文: Blanco-Hernández et al. 2024XPLANE (海外大学院留学支援コミュニティ)Editorial Notes:普段会ってもしょうもない話しかしない友人から、たくさん研究の話を聞けてとても楽しかったです。よーたろーの深い知見と説明力のおかげで素晴らしいTheta precessionの音声教科書が出来上がったと思います。(藤)今まで一視聴者として拝聴していたNeuroRadioでお話させていただけてとても光栄です！ちなみにDomeは部屋一つ分ほどの大きさがあり建設するのも大変で、Domeを作ってるうちに自然と筋肉がつきます笑 (末岡)一視聴者として拝聴しました。大変いいプログラムだなと思います(萩)これから空港とかで動く歩道の上を歩く度にこの論文の話を思い出しそうです (脇)

Le Nigeria a réalisé un parcours sans faute avec trois victoires dont la dernière hier face à l'Ouganda. Est-ce l'équipe qui vous a le plus impressionné pendant cette phase de poules ? Avancent ils masqués pour la phase finale ? Sentez-vous Osimhen en mission ? Attendiez-vous qu'il puisse aider en ne marquant pas ? La Tunisie a elle concédé le nul face à la Tanzanie, un match seulement en gestion ? Est-ce le retour de la mentalité des "Italiens d'Afrique" ? Le match face au Mali est-il un piège ?

Episode 746: Neal and Toby revisit some of the biggest trends of the year! A big theme? What we're putting into our bodies with the rise of creatine, caviar, dubai chocolate, and spicy foods. Then, why Gen Z is averse to opening bar tabs but all-in on communal dining. Then, we're tapping into our inner elder-selves with an uptick of grandma hobbies and reading fiction books, but there's a disparity between men and women. Also, a callback of days-old traditions, anybody? Metal braces are back for teens and cigarettes on the silver screen are back. Finally, Neal shares his favorite trends on 6-7, interest in history, and fast walking.  Check out https://www.public.com/morningbrew for more Subscribe to Morning Brew Daily for more of the news you need to start your day. Share the show with a friend, and leave us a review on your favorite podcast app. Listen to Morning Brew Daily Here:⁠ ⁠⁠https://www.swap.fm/l/mbd-note⁠⁠⁠  Watch Morning Brew Daily Here:⁠ ⁠⁠https://www.youtube.com/@MorningBrewDailyShow⁠ Paid endorsement. Brokerage services provided by Open to the Public Investing Inc, member FINRA & SIPC. Investing involves risk. Not investment advice. Generated Assets is an interactive analysis tool by Public Advisors. Output is for informational purposes only and is not an investment recommendation or advice. See disclosures at public.com/disclosures/ga. Past performance does not guarantee future results, and investment values may rise or fall. See terms of match program at https://public.com/disclosures/matchprogram. Matched funds must remain in your account for at least 5 years. Match rate and other terms are subject to change at any time. Learn more about your ad choices. Visit megaphone.fm/adchoices

iMetal Resources (TSXV: IMR | OTCQB: IMRFF | FRA: A7VA) has completed its 2025 Phase 1 drill program at the Gowganda West Gold Project in Ontario, with focus now turning to the upcoming assay results.In this interview, President and CEO Saf Dhillon discusses the Phase 1 drilling completion, a strategic antimony opportunity in Bosnia, key catalysts to watch in 2026, and more.Learn more about iMetal Resources: https://imetalresources.ca/Watch the full YouTube interview here: https://youtu.be/otNprlTgQJwAnd follow us to stay updated: https://www.youtube.com/@GlobalOneMedia

What if the stress, chaos, and hidden workload of managing your property while living abroad could be replaced with clarity, control, and peace of mind? In this episode, I sit down with Oscar Rubio, founder and CEO of Lodgering, a SaaS platform designed to solve one of the most emotionally taxing problems in real estate and mobility: managing a home from thousands of miles away. Oscar shares the deeply personal journey that led him from overworked "one-man orchestra" to leading a scalable, global platform used by institutions, homeowners, and relocated professionals. We explore the messy realities of mobility—overbookings, lost bookings, endless emails, operational burnout, and stressful overseas incidents—and how Oscar transformed years of painful, unscalable work into a streamlined, AI-powered ecosystem designed to give every user what they truly want: safety, clarity, and peace of mind. This is a conversation about resilience, reinvention, and building a business that supports your life—not the other way around. On This Episode 01:10 — The early days: visiting properties in person, doing everything manually, and learning relocation from the ground up 01:50 — Building multiple companies in Madrid… until COVID nearly shut everything down 02:23 — The turning point: digitizing every process into a scalable ecosystem—Lodgering 02:49 — Kyle introduces the idea of a multi-sided marketplace and asks Oscar how Lodgering works 03:14 — Oscar explains why Lodgering is a SaaS, not a marketplace—and why connecting platforms multiplies value 03:39 — Kyle frames Oscar's entrepreneurial journey as a story of scaling through repeated reinvention 04:11 — Oscar explains why experience is both "your enemy and your ally" when building a company 04:36 — Why resilience and learning from mistakes define long-term entrepreneurial growth 05:02 — Kyle asks about the real problems faced by Oscar's ideal clients 05:33 — Oscar describes hearing from CEOs: "you digitalized all our pains" 05:59 — Where the chaos really begins: managing 6+ booking platforms with no centralization 06:10 — The consequences: overbookings, underbookings, lost revenue, missed emails, and zero visibility 06:45 — Kyle presses for more specifics—and Oscar breaks down the true operational pain points 07:00 — Tenant issues, contracts, payments, incidents, and too many tools stitched together 08:00 — Why moving abroad is inherently stressful—and how Lodgering reduces that emotional load 08:41 — Kyle reflects on the "part-time job" hidden inside what should be passive income 09:07 — Oscar reveals the burnout facing operational teams and why they often quit 09:59 — The chaos spiral: missed calls, unanswered emails, confusion between owners, tenants, and institutions 10:11 — Kyle clarifies the definition of "relocated"—midterm stays of 1–11 months 11:06 — The mid-term rental boom: engineers, students, and global project workers 11:25 — The hidden burden for international offices and HR teams 12:00 — Kyle asks what makes Lodgering truly different 12:20 — Oscar reveals Phase 2: integrating AI to anticipate needs, automate proposals, and match services 13:13 — Kyle explores the benefits: saving time, saving money, protecting reputation 13:49 — Oscar describes how incident data helps predict, prevent, and budget issues 14:45 — Lodgering as a system for increasing occupancy, reducing operations costs, and improving decisions 15:00 — Kyle summarizes what users want: safety, clarity, peace of mind 15:21 — Oscar shares Lodgering's internal philosophy: "We Do Care," emphasizing empathy, not just technology 16:15 — Kyle begins the emotional story-mining process—inviting Oscar to recall core moments 17:08 — Oscar's breakthrough realization: booking emails in spam, endless paperwork, and unscalable chaos 18:32 — Kyle asks what Oscar's life looked like during this period 18:45 — Oscar shares honest details: 13–14 hour days, weekends preparing agendas, work as a "hobby" 19:25 — Golf: the only thing that finally pulled him out of work mode 20:10 — Kyle connects his experience to the emotional journey of Oscar's clients 20:36 — Oscar discusses ambition, effort, and the endless drive to improve 21:14 — Kyle asks for the contrasting future moment—when things finally aligned 21:50 — Oscar shares his dream: entrepreneur support, family time, and golf 22:30 — What has already changed: hiring an executive team, stepping into strategic leadership 22:55 — Leaving behind the "one-man orchestra" 23:09 — Kyle retells Oscar's story live—emotional, vivid, narrative form 26:43 — Oscar reacts: "You crossed my mind… that's exactly my story." 27:14 — Oscar reflects on the interview experience—"different in the best way" 27:28 — Where to find Oscar and learn more about Lodgering 27:55 — Closing the episode

In this episode of the Science of Skin podcast, Dr. Ted Lain and Dr. Andrew Alexis discuss Triferatine Cream, a novel fourth-generation retinoid. They explore its mechanism of action, clinical efficacy, and the importance of addressing not only acne lesions but also the psychosocial impacts of acne on patients. The conversation delves into the results of phase three and phase four clinical trials, highlighting Triferatine's effectiveness in treating both acne and post-inflammatory hyperpigmentation. The episode emphasizes the need for dermatologists to consider the entire acne journey and the long-term benefits of retinoid therapy for their patients. To watch this an other episodes, be sure to check out our YouTube page Takeaways: Triferatine is a novel fourth-generation retinoid. It binds preferentially to the RAR gamma receptor, enhancing its efficacy. Triferatine not only treats acne but also improves scarring and pigmentation. Clinical trials show significant efficacy in both facial and truncal acne. The psychosocial impact of acne is profound and long-lasting. Retinoids are foundational in acne treatment regimens. Patients benefit from continued use of retinoids beyond acne clearance. Phase four studies demonstrate Triferatine's effectiveness in reducing atrophic scars. Acne-induced hyperpigmentation is a significant concern that needs addressing. Education about retinoids can improve patient compliance.See omnystudio.com/listener for privacy information.

Au programme de Radio Foot pour cette deuxième émission en direct : nous reviendrons sur les dernières rencontres du groupe C, celui du Nigeria et de la Tunisie, et sur les matches du groupe D, où le Sénégal et la RDC se disputaient à distance la première place. Compte-rendu de nos envoyés spéciaux à Rabat et à Tanger. Nous évoquerons également les ultimes rencontres de ce mercredi, qui concernent notamment le Burkina Faso et l'Algérie. Dans la première partie de Radio Foot :CAN 2025: dénouement dans les groupes C et D   Pour débattre avec Annie Gasnier : Freddhy Koula, Ludovic Duchesne, et Yusuf Mouloumbou. Technique/réalisation Laurent Salerno - Préparation : David Fintzel. Calendrier CAN 2025 : programme complet, dates et horaires des matchs

Laut dem russischem Außenminister Sergej Lawrow wurde in der Nacht zum Montag Putins Präsidentenresidenz von der Ukraine angegriffen. Der ukrainische Präsident Wolodymyr Selenskyj bezeichnet dies als „gefälschte Geschichte“. Trump sprach von einer „heiklen Phase“, er habe ein positives Telefonat mit Putin geführt.

Au programme de Radio Foot pour cette deuxième émission en direct : nous reviendrons sur les dernières rencontres du groupe C, celui du Nigeria et de la Tunisie, et sur les matches du groupe D, où le Sénégal et la RDC se disputaient à distance la première place. Compte-rendu de nos envoyés spéciaux à Rabat et à Tanger. Nous évoquerons également les ultimes rencontres de ce mercredi, qui concernent notamment le Burkina Faso et l'Algérie. Dans la première partie de Radio Foot :CAN 2025: dénouement dans les groupes C et D   Pour débattre avec Annie Gasnier : Freddhy Koula, Ludovic Duchesne, et Yusuf Mouloumbou. Technique/réalisation Laurent Salerno - Préparation : David Fintzel. Calendrier CAN 2025 : programme complet, dates et horaires des matchs

In this episode of the Milk Road Show, Bitwise CIO Matt Hougan and Head of Research Ryan Rasmussen lay out their Top 10 predictions for 2026, and the message is clear: crypto is leaving its speculative adolescence and entering institutional adulthood.~~~~~

Drs Harrington and Gibson's annual review of cardiovascular medicine: ACS guidelines, antiplatelet management, GLP-1s, and ever lower LDL-C with drugs or even gene editing are among the highlights. This podcast is intended for healthcare professionals only. To read a transcript or to comment, visit https://www.medscape.com/author/bob-harrington New ACS Guidelines 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes https://doi.org/10.1161/CIR.0000000000001309 ACS Guideline Chair and Vice-Chair Discussion https://www.medscape.com/viewarticle/acs-guidelines-2025-key-points-chair-and-vice-chair-2025a100093l Antiplatelet/Antithrombotic Strategies Prasugrel Beats Ticagrelor in High-Risk Patients With Diabetes After PCI https://www.medscape.com/viewarticle/prasugrel-beats-ticagrelor-high-risk-patients-diabetes-after-2025a1000wbt Early Withdrawal of Aspirin after PCI in Acute Coronary Syndromes (NEO-MINDSET) https://www.nejm.org/doi/full/10.1056/NEJMoa2507980 Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation (AQUATIC) https://www.nejm.org/doi/full/10.1056/NEJMoa2507532 Bayesian Machine Learning Model Guiding Iterative, Personalized Anticoagulant Dosing Decision-Making : ENGAGE AF-TIMI 48 Trial Analysis https://doi.org/10.1016/j.jacadv.2025.102504 Factor XI Inhibitors Bristol Myers, J&J Stop Blood Clotting Drug Trial After Interim Review https://www.medscape.com/s/viewarticle/bristol-myers-j-j-stop-blood-clotting-drug-trial-after-2025a1000vqu Bayer's Asundexian Met Primary Efficacy and Safety Endpoints in Landmark Phase III OCEANIC-STROKE Study in Secondary Stroke Prevention https://www.bayer.com/en/us/news-stories/oceanic-stroke OAC-Naive Subgroup From OCEANIC-AF Published https://www.medscape.com/viewarticle/novel-blood-thinner-shows-promise-atrial-fibrillation-2025a10008lz GLP-1 and Myotrophic Drugs Lilly's Next-gen Drug Shows Greater Weight Loss Than Zepbound in Late-stage Trial (TRIUMPH-4) https://www.medscape.com/s/viewarticle/lillys-next-gen-drug-tops-zepbound-weight-loss-late-stage-2025a1000ys1 Amylin Analog Eloralintide Reduces Weight in Phase 2 Trial https://www.medscape.com/viewarticle/amylin-analog-eloralintide-reduces-weight-phase-2-trial-2025a1000uqf CRISPR and Lipid Lowering Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease https://www.nejm.org/doi/full/10.1056/NEJMoa2504747 Gene Therapy Shows Lipid Improvement but Raises Flags https://www.medscape.com/viewarticle/gene-therapy-shows-lipid-improvement-raises-flags-2025a1000uzw Phase 1 Trial of CRISPR-Cas9 Gene Editing Targeting ANGPTL3 https://www.nejm.org/doi/full/10.1056/NEJMoa2511778 Evolocumab in Patients without a Previous Myocardial Infarction or Stroke (VESALIUS-CV) https://www.nejm.org/doi/pdf/10.1056/NEJMoa2514428 Prehospital GLP IIb/IIIa Zalunfiban at First Medical Contact for ST-Elevation Myocardial Infarction (CELEBRATE) https://evidence.nejm.org/doi/full/10.1056/EVIDoa2500268 You may also like: Hear John Mandrola, MD's summary and perspective on the top cardiology news each week, on This Week in Cardiology https://www.medscape.com/twic Questions or feedback, please contact news@medscape.net

Beim Auftakt der Vierschanzentournee in Oberstdorf sorgt Felix Hoffmann für ein deutsches Happy End. kicker-Expertin Isabella Fischer schätzt das Springen der DSV-Adler ein. Außerdem: Die Darts-WM geht in die heiße Phase. kicker-Redakteur Christoph Laskowski verrät, wer Luke Littler noch aufhalten könnte.

Watch The X22 Report On Video No videos found (function(w,d,s,i){w.ldAdInit=w.ldAdInit||[];w.ldAdInit.push({slot:17532056201798502,size:[0, 0],id:"ld-9437-3289"});if(!d.getElementById(i)){var j=d.createElement(s),p=d.getElementsByTagName(s)[0];j.async=true;j.src="https://cdn2.decide.dev/_js/ajs.js";j.id=i;p.parentNode.insertBefore(j,p);}})(window,document,"script","ld-ajs");pt> Click On Picture To See Larger PictureGermany has followed the [CB]/[WEF] green new scam and now the manufacturing jobs imploding. Germany will struggle in 2026. The debt in the US is made up of fraud, its most likely in the trillions. There a silver storm approaching and the gap between gold and silver will close as the [CB] loses control. Sound money is the only way. The [DS] is now panicking, their money laundering scheme is being exposed, the people now know that they funnel money via NGO’s and shell companies. This is bigger than anyone could ever imagine. We are in the exposure and investigative phase, Next is the cleanup, then justice. To bring down the entire corrupt system, it must be done right, it must carry weight, we must follow the rule of law, good thinks sometimes take time. Economy (function(w,d,s,i){w.ldAdInit=w.ldAdInit||[];w.ldAdInit.push({slot:18510697282300316,size:[0, 0],id:"ld-8599-9832"});if(!d.getElementById(i)){var j=d.createElement(s),p=d.getElementsByTagName(s)[0];j.async=true;j.src="https://cdn2.decide.dev/_js/ajs.js";j.id=i;p.parentNode.insertBefore(j,p);}})(window,document,"script","ld-ajs"); Half of Germany's Manufacturing Sectors Anticipate Significant Layoffs and Job Losses in 2026   Germany is the epicenter of the European Union's overall goal to chase the green energy agenda. For the past several years Germany has been deconstructing their fossil fuel energy production and replacing it with far more expensive alternatives.  This has led to large increases in overall energy prices, and downstream increases in manufacturing costs. The consequences have been snowballing throughout 2025, while cheap competitive alternatives coming into the EU from China have compounded their problem.  Recently a survey of major industries was conducted in Germany to determine the forecast for 2026, the results are not good. Approximately half of the industrial sectors in Germany are anticipating job losses, cuts or layoffs this year. 22 out of 46 business associations are preparing to downsize their labor force.  Only 9 of the 46 are expected to increase hiring.   Job losses are expected in auto manufacturing, the textile sector, wood and paper fabrication.  Job gains are expected in aerospace, shipbuilding and defense production – i.e. the war machinery. When the largest and most developed industrial economy in Europe is pinning its economic survival on war machinery, a particular momentum is created.  It is never a good outcome for Europe when Germany becomes reliant on war to maintain employment. Source: theconservativetreehouse.com https://twitter.com/stats_feed/status/2005654716462538992?s=20 2009 – $12T 2010 – $13.6T 2011 – $14.8T 2012 – $16.1T 2013 – $16.7T 2014 – $17.8T 2015 – $18.2T 2016 – $19.6T 2017 – $20.2T 2018 – $21.5T 2019 – $22.7T 2020 – $27T 2021 – $28.4T 2022 – $30.9T 2023 – $33.2T 2024 – $35.3T 2025 – $38.5T https://twitter.com/StephenM/status/2005494075793735925?s=20  self-loathing, self-denigration and the redistribution of our national resources to the states and peoples of the undeveloped world. https://twitter.com/profstonge/status/2005633652852437451?s=20 Political/Rights Trump-Kennedy Center Hits Jazz Star with $1M Lawsuit For Backing Out Of Christmas Eve Show Redd, a drummer and vibraphone player who has performed with legends including Dizzy Gillespie and Ray Brown, had hosted the Christmas Eve Jazz Jam at the Kennedy Center since 2006. He took over the tradition from bassist William “Keter” Betts and maintained it for nearly two decades. This year marked an abrupt departure from that longstanding commitment. “When I saw the name change on the Kennedy Center website and then hours later on the building, I chose to cancel our concert,” Redd told The Associated Press. The Trump-Kennedy Center is pursuing a $1 million lawsuit against jazz musician Chuck Redd after he withdrew from his annual Christmas Eve concert at the last minute, citing the recent addition of President Trump’s name to the venue.  Source: zerohedge.com https://twitter.com/libsoftiktok/status/2005398115030024201?s=20 DOGE Geopolitical Trump Administration Slashes UN “Humanitarian” Funding Pledge  The United States announced a $2 billion pledge for United Nations humanitarian aid programs on Monday, marking a sharp reduction from previous years as the Trump administration pushes for major reforms in global aid spending. This pledge represents a fraction of historical U.S. contributions, which have reached up to $17 billion in recent years, with voluntary funding often in the $8-10 billion range. Administration officials describe the amount as sufficient to keep America as the world's top humanitarian donor while demanding greater efficiency from UN agencies. The funding will flow through an umbrella mechanism controlled by the UN's Office for the Coordination of Humanitarian Affairs (OCHA), allowing targeted distribution to specific crises and countries. Initial priorities include 17 nations such as Bangladesh, Congo, Haiti, Syria, and Ukraine. Notably absent from the list are Afghanistan and the Palestinian territories, with officials stating Gaza aid will tie into ongoing peace efforts. Source: discernreport.com  War/Peace Did US Land Strikes On Venezuela Begin Last Week & No One Knew It? President Trump on Friday in a radio interview disclosed something which missed the attention of the US and global media. He let slip that a large land site had been knocked out by a strike from US forces in the Caribbean – however without specifying which country was hit (whether Venezuela or perhaps Colombia). o  According to the full remarks in context, the president said: “But every time I knock out a boat, we save 25,000 American lives. It’s very simple. And what’s happening is they’re having a hard time employment-wise, they can’t get anybody. And we just talked out, I don’t know if you read or you saw, they [Venezuela] have a big plant or a big facility where the ships come from. Two nights ago, we knocked that out. So we hit them very hard. But drugs are down over 97 percent. Can you believe it?” Some unnamed American officials suggested to the New York Times that the Commander-in-Chief was referring to a drug facility in Venezuela: Trump did not name the location of the facility, though American officials told the New York Times that the president was referring to a drug facility in Venezuela that was eliminated. The president's comment is the only report of such an attack. No other Latin American government, including Venezuela, has disclosed a strike of this sort. : Source: zerohedge.com  Zelensky Wants 50-Year(!) Security Guarantee From Trump A major point of disagreement remains security guarantees. Ukraine has been pushing maximalist demands for something akin to NATO Article 5 protections. It would be like getting all the benefits of being in NATO but without being a formal member of the Western military alliance. The Ukrainian side has revealed that President Trump had offered security guarantees for 15 years following a peaceful settlement, but Zelensky considered this much too short to protect from future potential Russian aggression. But in classic Zelensky fashion, he wants way more than this. Also, maximalist demands are something that European leaders have backed him on all along – and they may have even put him up to. According to The Wall Street Journal: Kyiv had asked for security guarantees to last up to 50 years after the end of the conflict during weekend discussions. In the documents currently being discussed, the U.S. offered a 15-year guarantee with the possibility of extension, Zelensky said in audio messages to journalists on Monday.   Source: zerohedge.com  Russia accuses Ukraine of military attack on Putin’s residence: ‘state terrorism’   Russia is promising retaliation against Ukraine for an alleged military attack on President Vladimir Putin’s residence in the northern Russia area of Novgorod, which Ukrainian President Volodymyr Zelensky deemed a lie intended to undermine peace talks, Reuters reports. . Russian Foreign Minister Sergei Lavrov said Monday that Russian air defenses destroyed all 91 long-range drones targeting Putin’s residence and that no one was injured and no damage reported. “Such reckless actions,” which Lavrov deemed “state terrorism,” will be answered with retaliatory strikes on targets in Ukraine, he said. Ukrainian President Zelensky says it’s a false claim intended to undermine peace talks  . Source: justthenews.com https://twitter.com/AutistDivision/status/2005463473006801341?s=20  geo-political territories forever. And lets be honest, they couldn’t get them back under any circumstances again. Medical/False Flags [DS] Agenda https://twitter.com/amuse/status/2005334470799565113?s=20   LAFD Battalion Chief Kenneth Cook rejected the final Palisades fire report after LAFD leadership removed critical findings tied to preparation failures before Jan. 7. Drafts obtained through public records show staffing violations, delayed assignments & ignored wind warnings were scrubbed from the final version. The report meant to save lives became a political shield. As a side note, New York City is setting themselves up for the same problem... https://twitter.com/amuse/status/2005608785990262859?s=20 https://twitter.com/EricLDaugh/status/2005622039999062219?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E2005622039999062219%7Ctwgr%5E11dcdb289244b9644ea68d25359a18f753233f5d%7Ctwcon%5Es1_c10&ref_url=https%3A%2F%2Fwww.thegatewaypundit.com%2F2025%2F12%2Fsomali-fraud-scandal-expands-as-lawyer-exposes-damning%2F   pushing for that in every single state!” “The state will, as long as the doctor has approved it, continue to pay you. It could be for 10 hours, 12 hours, up to 24 when it’s critical care.” “So you could sit at home without caring for an elderly parent who really doesn’t need it, make about $75,000 to $90,000 a year. Now you add two parents, that’s $180,000. Now you add your in-laws $250,000.” “You continue to add this and you wonder what are the services being provided? So a lot of providers came and said fraud is occurring because we said we weren’t going to rubber stamp this paperwork.” “So they went to other providers, their home health care networks saying we’ll make it worth your while. Well, sounds like a kickback to me.” “So we really need to investigate the Medicaid system and how much it’s increased since the Somalian population came and who really needs critical care because that’s meant for our disabled, our elderly and people who really need it, not to just live off our system.” “And that’s what’s happening in Ohio. I think it’s ridiculous. I think it’s despicable, but authorities are now looking at it from the Attorney General’s office to the U.S. Attorney’s office.” “I flagged them all because this is Ohio tax dollars and we have to take it seriously. I’m tired of people telling me, well, this is the way it’s always been. It’s subjective and we can’t really check. No, you can.” https://twitter.com/ArthurMacwaters/status/2005324862756127166?s=20   this not instant jail?! Like this is electoral fraud on top of Medicare fraud How is this not front page of every newspaper?! https://twitter.com/elonmusk/status/2005535693918138533?s=20 https://twitter.com/amuse/status/2005657030111932568?s=20   was unanimously convicted by a jury only to have Judge Sarah West vacate the verdict. In two separate cases to other judges dismissed the cases against his wife and his brother. $7.2 million is gone and no one is being held accountable. This story is being repeated across Minnesota to the tune of more than $8 billion so far. Somali criminals in Minnesota have stolen more than Somalia’s GDP from American taxpayers. Why won’t Democrat judges hold them accountable? https://twitter.com/elonmusk/status/2005496793279439182?s=20 https://twitter.com/JoeLang51440671/status/2005476678261461399?s=20   broke to being worth up to $30 million in just a year — as a massive, up to $9 billion fraud scheme involving the Somali community in her district unfolded right under her nose in Minnesota.” $9 billion in fraud happened in her district? Can I ask the question? How many Somali daycares did Ilhan Omar own? “Close to 90 people have been charged so far, including at least three with direct ties to the lefty Squad member, though she has not been charged.” https://nypost.com/2025/12/27/us-news/ilhan-omars-hubbys-30m-firm-quietly-scrubs-names-from-website-as-squad-member-faces-mounting-questions-on-sudden-wealth-amid-minnesota-welfare-fraud/ That's going to change. Have we looked into the wealth of the brother she married? I wonder if he owns some Somali daycares in Minnesota? Tick Tock!! https://twitter.com/libsoftiktok/status/2005657804301013272?s=20  , the Google business listing for this center showed the phone number 651-201-3400, which is the official public contact line for the Office of Governor Tim Walz and Lt. Governor Peggy Flanagan    https://twitter.com/JoeLang51440671/status/2005329284785647715?s=20   significant investments in pre-K for four-year-olds as well as other early learning programs serving children and families birth-to-school entry. This year he focused on the country's youngest children and their families' need for high-quality child care.” The Obama administration was a gigantic money laundering operation. “The President explained the need in last Tuesday's address stating, “In today's economy, when having both parents in the workforce is an economic necessity for many families, we need affordable, high quality childcare more than ever.” “But the child care tax credit isn't all the President proposed.” “He would also significantly expand the Child Care and Development Fund(CCDF), a child care subsidy for low- and moderate-income families authorized under the Child Care Block Development Grant (CCDBG) Act. (CCDBG was reauthorized last year after 18 years.) By 2025, the proposed expansion would increase the reach of CCDF to an additional one million children, under four-years-old.” Taxpayers subsidies and grants for “childcare.” “The last part of the President's proposal, in typical Obama Administration-style, is a competitive grant that would promote innovation in the child care system. The proposed grants– totaling $100 million– would allow states to create pilot programs to determine the best ways to provide child care to vulnerable populations, including children with disabilities, parents who work non-traditional hours, and families who have difficulty finding high-quality child care.” https://newamerica.org/education-policy/edcentral/presidents-child-care-plan/ Taxpayers “grants” totaling $100 million (for starters) to be given to “vulnerable populations.” Can you say “Somali?” Taxpayers funding of “childcare,” was a “necessity” for the funding of the democrat party. The Somali community was always a hub of this “childcare” theft of taxpayers money. It was set up this way on purpose. A Somali community, governed by Somali's and protected by the democrat party. The Somali's were being brought into this country starting with the George W. Bush's presidency. But Obama began accelerating the number of refugees from Somalia along with other Muslim countries. Here's just the last year under Obama. “A total of 38,901 Muslim refugees entered the U.S. in fiscal year 2016, making up almost half (46%) of the nearly 85,000 refugees who entered the country in that period, according to a Pew Research Center analysis of data from the State Department's Refugee Processing Center. That means the U.S. has admitted the highest number of Muslim refugees of any year since data on self-reported religious affiliations first became publicly available in 2002.” “Just two countries – Syria (12,486) and Somalia (9,012) – were the source of more than half of fiscal 2016's Muslim refugees. The rest are from Iraq (7,853), Burma (Myanmar) (3,145), Afghanistan (2,664) and other countries (3,741).” https://pewresearch.org/short-reads/2016/10/05/u-s-admits-record-number-of-muslim-refugees-in-2016/ Obama was an installed puppet of Prince Alwaleed and was doing his bidding. Obama filled his administration with people tied to the Muslim Brotherhood, who were implementing their “civilization jihad.” These communities began electing corrupt representatives like Ilhan Omar. Infiltration not invasion. Taxpayers money was funneled into these communities through “childcare grants” and other “welfare programs,” in order to fund the democrat party. Minnesota is just the “doorway” into a much larger nationwide fraud scheme to fund the democrat party. A magnifying glass is about to be put on ALL state welfare programs that are receiving “federal funding.” These grants and benefits handed out to these crooks, are now the doorway to expose and bring them all to an end. BOOMERANG! https://twitter.com/everytime_11/status/2004718928686350461?s=20 https://twitter.com/EndWokeness/status/2005651406985036272?s=20 Tim Walz's Office Responds with an Outrageous Falsehood After Journalist Nick Shirley Exposes Fraud of the Century in Minnesota “The governor has worked for years to crack down on fraud and ask the state legislature for more authority to take aggressive action,” a spokesperson for Walz told Fox News. “He has strengthened oversight – including launching investigations into these specific facilities, one of which was already closed,” the spokesperson added. “(He) hired an outside firm to audit payments to high-risk programs, shut down the Housing Stabilization Services program entirely, announced a new statewide program integrity director, and supported criminal prosecutions.” Walz previously called Shirley and others who have questioned his handling of the scandal “white supremacists.” Walz's team wants the public to believe that not only does the governor have no involvement in the scandal, but he has also been a leading advocate against this corruption. They must think that every day Americans have the same >IQ as Somali citizens.   Source: thegatewaypundit.com https://twitter.com/ElectionWiz/status/2005427571861909629?s=20 https://twitter.com/KevinKileyCA/status/2005329670083145745?s=20 Back on June 24, 2025. about 31% of applications to California’s 116 community colleges were deemed likely fraudulent by the chancellor’s office—equating to over 1.2 million fake applications. These were mostly detected and blocked before enrollment or aid disbursement, but some fraud succeeded, costing millions in stolen financial aid (around $11 million total in 2024, a small fraction of the billions distributed overall).The piece discusses ongoing efforts to combat the issue, like improved detection tools, identity verification, and a proposed $10 application fee to deter bots and scammers targeting the free-application, open-access system.  https://twitter.com/CynicalPublius/status/2005388876807057913?s=20 President Trump's Plan https://twitter.com/stats_feed/status/2005654716462538992?s=20 2009 – $12T 2010 – $13.6T 2011 – $14.8T 2012 – $16.1T 2013 – $16.7T 2014 – $17.8T 2015 – $18.2T 2016 – $19.6T 2017 – $20.2T 2018 – $21.5T 2019 – $22.7T 2020 – $27T 2021 – $28.4T 2022 – $30.9T 2023 – $33.2T 2024 – $35.3T 2025 – $38.5T https://twitter.com/4nt1p4tt3rn/status/2005345471674388575?s=20  deniability to the federal and state governments, and allow them to funnel money into the NGOs to do what the governments either don’t want to (due to optics) or can’t (due to legal constraints) do. They are quite literally dismantling the United States of America, and they’re doing it with YOUR money. Quite literally money taken out of your pockets. Food taken out of your children’s mouths. They’re directly or indirectly responsible for: * the massive invasion of this country by illegals * the high cost of healthcare * the shortage and high price of homes * the shortage and high price of unimproved land * the high cost of food and other goods * the high taxes you’re forced to pay * the skyrocketing national debt * the skyrocketing federal deficit * DEI and the elimination of qualified American workers from jobs * deaths of Americans on our roadways * the broken “justice” system In other words, literally everything everyone’s complaining about. https://twitter.com/911NewsBreaks/status/2005660846848958944?s=20   planning to livestream a racially motivated extremist attack with pipe b-mbs and g-ns. https://twitter.com/HarmeetKDhillon/status/2005444604624028029?s=20   year later as special counsel in November … statute runs on his obvious shenanigans late 2027 * Democrats in Congress and those in the states colluding with Biden WH hide their behavior, some of which STILLL HASN'T come to light! Statute runs on this five years after their concealed behavior is known to the government. This means the statute could run in the next administration. STOP POSTING CLICKBAIT BS!!! You are being used! https://twitter.com/HarmeetKDhillon/status/2005446072634872033?s=20 https://twitter.com/grok/status/2005427970681217334?s=20   to Jan. 6, 2021/2026. Specific cases vary by act. ‘Ten-year stain:' Bondi asks prosecutors to probe Obama-Biden lawfare as criminal conspiracy FBI Director Kash Patel penned a memo predicating an investigation looking at the weaponization of intelligence and law-enforcement powers dating to the Russia collusion case as an ongoing conspiracy. Attorney General Pam Bondi   asked the prosecutors to investigate the Obama-Biden era of lawfare as an ongoing election-meddling conspiracy that protected Democrats from criminal investigation and infringed the civil rights of Republicans like President Donald Trump and his supporters. An “ongoing conspiracy” and the statute of limitations Such an approach allows prosecutors to charge defendants with alleged crimes outside the statute of limitations because they were connected to an ongoing conspiracy, much like those cases brought against the mafia and drug cartels. “At my direction, our U.S. Attorneys and federal agents are actively investigating instances of government weaponization nationwide,” Bondi said. “This is a ten-year stain on the country committed by high-ranking officials against the American people. Source: justthenews.com https://twitter.com/WarClandestine/status/2005434508124782615?s=20   to be deported. They opposed the One Big Beautiful Bill because it funds ICE/US MIL, and they know Trump is going to invoke the Insurrection Act to deploy troops to their cities to assist ICE in deporting the illegals. If the Dems can't cheat in elections, they lose access to our tax dollars, and thus they lose all their power. They never cared about diversity, equality, equity, inclusion, immigration or any of that shit. It was all just a transaction. Everything they say and do is just a means to justify their treasonous scheme to steal our tax dollars. That's why it's so important to nuke the filibuster, pass the Save Act, invoke the Insurrection Act, deport all the illegals, and arrest everyone involved. If we don't, the Dems will take complete control, we will become a one-party State, and they will eventually phase us out via mass immigration. That's why the Dems have been trying to destroy, obstruct, and kill Trump, ever since he came down the escalator. Because they knew that he knew about all this, and is on a mission to stop it. The American People are being replaced, and the Democrats are directly responsible for it. This is the battle for the Republic. 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In this episode of the Garage Gym Athlete podcast, Jerred and Dave explore the idea of consistently choosing the hard right over the easy wrong across fitness, business, family, and life. Using Dave's story and the philosophy behind Garage Gym Athlete as the backdrop, they discuss why long-term alignment, daily discipline, and values-driven decisions matter more than quick wins or short-term optimization. The conversation reinforces that real progress is built through consistency, self-awareness, and intentional choices made over years, not through hacks or intensity spikes. At its core, the episode challenges listeners to commit to the long game and become the kind of person who shows up—especially when it's harder, not easier. 00:00 Why This Episode Exists: Choosing the Long Game 02:10 Dave's Background and the Foundations of Discipline 05:45 Education vs. Self-Education and Owning Your Growth 09:20 Leaving Comfort: Moves, Risk, and Alignment 13:40 Marriage, Family, and Letting Constraints Sharpen You 18:30 Fitness as Identity, Not a Phase 22:10 Coaching, Craft, and Rejecting Short-Term Fitness Wins 26:15 Why Garage Gym Athlete Is a Long-Term Play 30:05 Community, Consistency, and Doing Life Together 33:45 Choosing the Hard Right Over the Easy Wrong (Final Takeaways)

Israel's Prime Minister Benjamin Netanyahu has met President Donald Trump in Florida to discuss Gaza's future, including the issue of Hamas' disarmament. The two leaders also spoke about Iran's nuclear programme and the fragile Hezbollah-Israel ceasefire in Lebanon.Also on the programme: British boxer Anthony Joshua has been injured in a car crash in Nigeria; shopkeepers in Tehran have been demonstrating over the depreciating rial; and a special report on songbird poaching in China.(Photo: U.S. President Donald Trump speaks to the media next to Israeli Prime Minister Benjamin Netanyahu upon arrival for meetings at Trump's Mar-a-Lago club in Palm Beach, Florida, U.S., December 29, 2025. REUTERS/Jonathan Ernst)

Israel's Prime Minister Netanyahu has flown to Mar-a-Lago to meet President Trump in a high-stakes showdown over Gaza, Hezbollah, and Iran's growing threats. The U.S. is pushing for Phase 2 of the ceasefire, but Hamas still holds hostages and Israel faces constant terror attacks at home. Meanwhile, Israel deploys the world's first operational laser defense system, the Iron Beam, sending a clear message to its enemies: do not test us. From foreign pressure to threats on every front, the future of Israel hangs in the balance — but restoration and hope continue to flourish in the land of Israel.

Episode Description In this year-end episode, Chris Wolfe, OD takes a step back from protocols, products, and positioning statements to examine a more fundamental question in clinical care: when does belief help us act, and when does belief get ahead of the data? Throughout the year, we've emphasized that belief during the comprehensive exam is what drives action. If doctors and teams do not truly believe something matters, it does not get prioritized. But belief has a failure mode. When belief outpaces evidence, especially in pediatric care, it can distort expectations, decision-making, and policy. Using the FDA's decision on low-dose atropine as a case study, this episode explores how belief forms, how it spreads, and where it may diverge from what the publicly available data actually show. This is not an argument against myopia management or atropine therapy. It is an attempt to slow the conversation down and examine effect size, study design, endpoints, and uncertainty with clarity and humility. What You'll Learn in This Episode Why myopia management itself is not the controversy, but certainty often is How belief influences behavior in the comprehensive exam, for better and for worse What the FDA actually said in its Complete Response Letter on SYD-101 How professional statements and press releases can amplify belief beyond available data What the STAR trial poster does and does not show, including effect size and subgroup uncertainty Why modest effect sizes behave differently in real-world clinical practice How to think about dose, endpoints, and population selection without oversimplifying Why belief should motivate action, but evidence should calibrate expectations Key Sources Referenced in This Episode FDA and Manufacturer Statements Sydnexis Complete Response Letter Press Release Sydnexis Receives Complete Response Letter from FDA for SYD-101 to Slow Pediatric Myopia Progression https://www.sydnexis.com/news/sydnexis-receives-complete-response-letter-from-fda-for-syd-101 Sydnexis Phase III STAR Trial Topline Data Press Release Sydnexis Announces Topline Pivotal Data from Phase 3 STAR Trial https://www.sydnexis.com/news/sydnexis-announces-topline-pivotal-data-from-phase-3-star-trial UK Approval Announcement (Based on STAR Data) Sydnexis Announces UK Approval of Ryjunea by Partner Santen https://www.sydnexis.com/news/sydnexis-announces-uk-approval-of-ryjunea Professional Organization Statements AAOMC Public Statement AAOMC Calls for Access to Proven Myopia Therapies as Low-Dose Atropine Gains Global Approvals https://aaomc.org AAPOS Commentary on Nonapproval of SYD-101 Available via LinkedIn and Healio OSN Clinical Commentary and Analysis Kyle Klute, OD – Optometry Simplified My Alternative Take on Atropine, Fast Progressors, and Effect Size (NNT Analysis) https://optometrysimplified.com/posts/optometry-simplified-weekly-my-alternative-take-on-atropine-fast-progressors-in-glaucoma-lab-test-ordering-and-more Strongly recommended for a detailed discussion of effect size and Number Needed to Treat. This episode references Kyle's framework without reproducing his calculations. Review of Myopia Management – Ashley Wallace Tucker, OD What Does the FDA Decision on SYD-101 Mean for Eye Care? Review of Optometry – Paul Karpecki, OD Sydnexis Snubbed Review of Optometry – Cory Lappin, OD Optometric Physician Commentary on SYD-101 Healio OSN – Ed Wilson, MD and John Hovanesian, MD AAPOS: Nonapproval of SYD-101 Has Important Implications Why This Episode Matters This episode is not about picking sides. It is about learning to sit in uncertainty without abandoning action. It challenges listeners to examine where belief helps patient care and where belief may unintentionally replace careful analysis. If you manage myopia, counsel parents, interpret clinical trials, or influence policy, this episode is designed to help you think more clearly, not more loudly. Connect and Continue the Conversation If this episode resonated with you, or if you found yourself uncomfortable in parts of it, that reaction is worth exploring. Thoughtful medicine requires both conviction and restraint. ------------------- For our listeners, use the code 'EYECODEMEDIA22' for 10% off at check out for our Premiere Billing & Coding bundle or our EyeCode Billing & Coding course. Sharpen your billing and coding skills today and leave no money on the table! questions@eyecode-education.com https://coopervision.com/myopia-management Go to MacuHealth.com and use the coupon code PODCAST2024 at checkout for special discounts  Show Sponsors: CooperVision MacuHealth

durée : 00:15:20 - Journal de 8 h - Le président des Etats-Unis recevra ce lundi soir le Premier ministre israélien Benjamin Netanyahu. Les deux dirigeants devraient évoquer la deuxième phase du plan de paix poussé par Washington.

The Road to Doomsday continues as Jarod and Taylore wrap up Phase 2 with the introduction of Ant-Man and bask in the glory of this off beat and charming heist flick.Sunday's Bloody Mary: https://sundaysbloodymary.com/shop/ Luminous Odyssey:https://www.youtube.com/c/AllRemainingSystems Mitch692 Channel: https://www.youtube.com/@TheMitch692Channel Help us out by chuckin' a buck on our Patreon: https://www.patreon.com/thenerdacademypodcast

Notre newsletter : https://bit.ly/newsletter-performance1 Youtube : https://bit.ly/youtube-extraterrienPodcast Spotify : https://spoti.fi/2Ke47WkPodcast Apple : http://bit.ly/extraterrien Instagram : https://www.instagram.com/extraterrien.podcast/ Le programme d'entrainement Hyrox : https://www.roxevolution.com/La formation pour devenir podcasteur : https://bit.ly/lance-ton-podcastLa méthode pour vivre de son podcast : https://bit.ly/podcasteur-pro --- Mon framework pour un bilan annuel sans bullshitOn vit à 100 à l'heure, les yeux rivés sur le prochain sommet, sans jamais prendre le temps de regarder dans le rétro. Pourtant, le bilan n'est pas une option : c'est l'occasion de se regarder en face sans se mentir.Je vous rappelle mon framework d'apprentissage, celui que j'applique à chaque projet : Objectif → Test → Mesure → Bilan & Réajustement.C'est exactement ce que font les militaires après chaque mission : un débriefing froid et factuel. Sans mesure, il n'y a pas de progression.

Moon Medicine: The 8 Sacred Phases Of The Moon for Healing Breathing Moonlight is a Story of Grief, Healing, and Transformation Told Through the 8 Phases of the MoonHave you lost someone you love and wondered how to keep breathing through the heartbreak?This deeply personal and spiritual story offers a powerful new perspective on grief through the lens of the 8 phases of the moon.

durée : 00:15:20 - Journal de 8 h - Le président des Etats-Unis recevra ce lundi soir le Premier ministre israélien Benjamin Netanyahu. Les deux dirigeants devraient évoquer la deuxième phase du plan de paix poussé par Washington.

U.S. President Donald Trump says the disarmament of Hamas is a key condition for the second phase of the Gaza peace plan.

durée : 00:15:20 - Journal de 8 h - Le président des Etats-Unis recevra ce lundi soir le Premier ministre israélien Benjamin Netanyahu. Les deux dirigeants devraient évoquer la deuxième phase du plan de paix poussé par Washington.

Phase IX of The Change Leader's Roadmap: Learn and Course Correct is your guide for wrapping up your project effectively and supporting the organization to continue to uplevel its change leadership capability from have learned from how this project was led. Learning and Course Correcting refers to what occurred in how you handled the work of all four quadrants: Content (Systems), Mindset, Behavior and Culture change. It ensures that continuous improvement of the New State is supported, and that best change practices for how the project was led are identified and housed so they can be trained and followed in future projects. This Phase also supports you to dismantle any temporary structures, systems, polices and roles that are no longer needed, as well as the identification of those to formalize because they continue to add value to the new organization, which is an agile move!Hosted on Ausha. See ausha.co/privacy-policy for more information.

The FiltrateJoel Topf‍ ‍@kidneyboy.bsky.social‬ (COI)Sophia Ambruso @sophia-kidney.bsky.socialSwapnil Hiremath @hswapnil.medsky.social and on LinkedInSpecial Guests Jonathan Barratt Professor of Renal Medicine, University of Leicester Google Scholar (COI: all the companies)Editing and Show Notes byNayan Arora @captainchloride.bsky.socialThe Kidney Connection written and performed by Tim YauShow NotesProteinuria Reduction as a Surrogate End Point in Trials of IgA Nephropathy (Aliza Thompson, 2019 PubMed)The number, quality, and coverage of randomized controlled trials in nephrology (PubMed 2004)A Randomized, Controlled Trial of Rituximab in IgA Nephropathy with Proteinuria and Renal Dysfunction (PubMed 2017)BLISS Belimumab in lupus nephritis (NephJC | PubMed)The Phase 2 trial of atacicept A phase 2b, randomized, double-blind, placebo-controlled, clinical trial of atacicept for treatment of IgA nephropathy (PubMed)The phase 3 trial of atacicept, the subject of this podcast A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy (PubMed | NephJC)The use of Gd-IgA1 in the Testing Trial Role of Systemic Glucocorticoids in Reducing IgA and Galactose-Deficient IgA1 Levels in IgA Nephropathy (PubMed)If you can't get enough Jon Barratt, take a look at his grand rounds at The University of Ottawa. Updates to the KDIGO Guidelines for the treatment of IgA nephropathy, with Prof Jonathan Barratt (YouTube)Tubular SecretionSwapnil Hiremath Pluribus on Apple TV (Wikipedia)Jon Barratt Lynyrd Skynyrd (Wikipedia) Slow Horses (Wikipedia) on AppleTVJoel Topf the new ASN

In this episode, we're diving deep into how your spirit guides are actually assigned to you, and it's completely in alignment with your Divine Plan. Your spirit guides aren't just floating in and out of your life, they're here with a sacred purpose. Some have been with you for lifetimes. Others arrive during soul activations, spiritual initiations, or major life shifts. And yes… you chose many of them in collaboration with your higher self and Council of Light before you incarnated. In this session, I'll walk you through how spirit guides are selected based on your soul blueprint, purpose, and karmic lessons. We explore primary guides, phase-based guides, ancestral support, and even “divine plan adjusters” who step in when life takes a detour (or quantum leap!). What We Cover Understand how spirit guides are assigned pre-birth in collaboration with your Council of Light to support your soul mission and karmic lessons. Learn the difference between primary guides (who stay with you for life) and phase-based guides who appear during key soul shifts and activations. Discover why your soul chooses your personality, path, and gifts, before incarnation, and how your guides are matched accordingly. Explore the roles of ancestral guides, angelic beings, cosmic support, and divine deities like Isis or Lakshmi in your spiritual team. Find out what happens when you deviate from your soul path, and how “divine plan adjuster” guides intervene to realign you. Get clear on the impact of free will on your soul plan and why asking for divine interference can quantum leap you back into alignment. Learn how to consciously choose and call in guides to support your next level of expansion, healing, or service. ✨ Whether you've felt disconnected from your spiritual team or you're ready to deepen your relationship with them, this episode will help you understand how supported you truly are, and how to consciously call in more guidance, love, and alignment.

Nottingham Forest Foundation Phase Lead Nathan Cantrill joins Glen and Saul to discuss the clubs individual based programme focusing on out playing and making the players as good on the ball as possible.

In this episode, Dr. Rena Malik, MD breaks down what is truly "normal" when it comes to sex, exploring the sexual response cycle, timing, anatomy, and common myths. She addresses misconceptions fueled by media and adult films, offers science-based reassurance about sexual function and satisfaction, and encourages open communication for healthier, more enjoyable sexual experiences. Listeners will walk away feeling educated, empowered, and relieved about their own sexual health and relationships. Become a Member to Receive Exclusive Content: renamalik.supercast.com Schedule an appointment with me: https://www.renamalikmd.com/appointments ▶️Chapters: 00:00 Sex should be easy 00:43 Sexual Health 101 01:36 What happens in your body during sex 01:57 Sexual response cycle 02:24 Phase 1 Desire 03:22 Phase 2 Arousal 04:42 Phase 3 Orgasm05:29 Phase 4 Resolution 06:31 Timing of arousal and misconceptions 09:01 How long sex lasts 11:38 Normal genital anatomy 17:06 Common sex myths 21:21 Practical steps to improve sexual confidence Let's Connect!: WEBSITE: http://www.renamalikmd.com YOUTUBE: https://www.youtube.com/@RenaMalikMD INSTAGRAM: http://www.instagram.com/RenaMalikMD TWITTER: http://twitter.com/RenaMalikMD FACEBOOK: https://www.facebook.com/RenaMalikMD/ LINKEDIN: https://www.linkedin.com/in/renadmalik PINTEREST: https://www.pinterest.com/renamalikmd/ TIKTOK: https://www.tiktok.com/RenaMalikMD ------------------------------------------------------ DISCLAIMER: This podcast is purely educational and does not constitute medical advice. The content of this podcast is my personal opinion, and not that of my employer(s). Use of this information is at your own risk. Rena Malik, M.D. will not assume any liability for any direct or indirect losses or damages that may result from the use of information contained in this podcast including but not limited to economic loss, injury, illness or death. Learn more about your ad choices. Visit megaphone.fm/adchoices

Welcome to The Times of Israel's Daily Briefing, your 20-minute audio update on what's happening in Israel, the Middle East and the Jewish world. Legal and settlements reporter Jeremy Sharon joins host Amanda Borschel-Dan for today's episode. Defense Minister Israel Katz told settlements leaders on Tuesday that, “With God’s help when the time comes, we will also establish… pioneer groups in northern Gaza, in place of the settlements that were evacuated.” He later walked back his statements, but not before Finance Minister Bezalel Smotrich doubled down on them and also pushed for Prime Minister Benjamin Netanyahu to convince US President Donald Trump to recognize annexation of the West Bank in his upcoming US trip. We dive into the issues of Jewish settlements in the Gaza Strip and West Bank in the first half of the program. The IPC famine monitoring organization stated on Friday that food security conditions in the entire Gaza Strip “remain critical,” in a new report covering the second half of October and all of November that classified the territory as being in its “Emergency” Phase 4 category — the fourth highest of its five levels of food insecurity. Sharon explains Israel's criticism of the report and raises the question of whether the Hamas-run Gazan Health Ministry has been manipulating its numbers of war casualties. Earlier this month, the High Court of Justice ruled unanimously 7-0 to annul the government’s decision to fire Attorney General Gali Baharav-Miara, asserting that the government had failed to provide legal justification for its decision to change the way an AG is fired, and determining that the new system it designed was fundamentally flawed. Sharon reviews the decision and updates us on the ongoing existential crisis between the government and the court. Check out The Times of Israel's ongoing liveblog for more updates. For further reading: Katz vows Israel will build settlements in northern Gaza, later walks back comments Dozens of settler activists enter Gaza, plant Israeli flags in bid to resettle enclave PA accuses Israel of ‘tightening colonial control’ over West Bank with new settlements Government announces 19 new West Bank settlements and legalized outposts IPC monitor says ‘famine conditions’ over but Gaza food security still ‘critical’; Israel rejects findings Israel says famine monitor did not seek aid facilitators’ input for upcoming Gaza report High Court annuls firing of attorney general; cabinet ministers urge defiance of ruling Subscribe to The Times of Israel Daily Briefing on Apple Podcasts, Spotify, YouTube, or wherever you get your podcasts. This episode was produced by Podwaves. IMAGE: A tent camp for displaced Palestinians in Deir al-Balah, central Gaza Strip, December 23, 2025. (AP Photo/Abdel Kareem Hana)See omnystudio.com/listener for privacy information.