Podcasts about Research institute

Dr. Olga Klinkova, Infectious Diseases clinician at Moffitt Cancer Center and Research Institute, conducts a board review session on Candida Infections targeted towards the medical resident or Infectious Diseases Fellow. Topics discussed include a comparison and contrast of the different Candida species, information on Candida auris, Candidemia, and disseminated (hepatosplenic) candidiasis. Also discussed are novel antifungals used for azole-resistant candidiasis. Guidelines based reference sources are also mentioned.

Murdoch Children's Research Institute centre for adolescent help director Professor Susan Sawyer told 3AW Breakfast hosts Ross and Russel that families played an important part in regulating social media use for teenagers.See omnystudio.com/listener for privacy information.

An extra half hour of The Panel with Wallace Chapman, where to begin, he's joined by Nights host Emile Donovan. Then: 48 teams will be playing across USA, Canada and Mexico in the football World Cup and heat stress will be a factor as summer reaches its height in North America. FIFA has installed cooling breaks to help, but is it enough? Wallace talks to Professor Julien Périard, the Director of the Research Institute for Sport and Exercise at the University of Canberra about how heat stress works and how to mitigate it.

Keith Ferrazzi is Chairman of Ferrazzi Greenlight and its Research Institute. He is the author of the #1 New York Times bestseller ⁠Who's Got Your Back ⁠and bestsellers like Never Eat Alone, Leading Without Authority, and Competing in the New World of Work. He is a frequent contributor to Harvard Business Review, the Wall Street Journal, Fast Company, Forbes, Inc, Fortune, and other many other publications. He is also the author of a new book, which launches today, called ⁠Never Lead Alone⁠. In his third appearance on ⁠the Elevate Podcast⁠, Keith joined host Robert Glazer to discuss his new book, the move from leadership to teamship, and much more. Thank you to the sponsors of The Elevate Podcast Shopify: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠shopify.com/elevate⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Framer: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠framer.com/elevate⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Indeed: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠indeed.com/elevate⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Ethos Life: ⁠⁠⁠⁠⁠ethos.com/elevate⁠⁠⁠⁠⁠ Keeper Security: ⁠⁠⁠⁠⁠⁠keepersecurity.com/ELEVATE⁠⁠⁠⁠ Fora Travel: ⁠⁠foratravel.com/elevate⁠⁠ Northwest Registered Agent: ⁠⁠northwestregisteredagent.com/elevate⁠⁠ Whatnot: Search "Whatnot" in the app store to download Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

Ann & Robert H. Lurie Children's Hospital of Chicago is celebrating a multimillion-dollar donation that will help advance fertility and hormone preservation research. The $3 million gift to the hospital's Stanley Manne Children's Research Institute comes from the Mary and Ralph Gesualdo Family Foundation. $2 million will be used to directly support key research initiatives, and the remaining $1 million will establish the Gesualdo Family Research Scholar which will be an endowed position supporting the recruitment of a PhD scientist who is dedicated to advancing research in the field of fertility and hormone preservation and restoration.

Ann & Robert H. Lurie Children's Hospital of Chicago is celebrating a multimillion-dollar donation that will help advance fertility and hormone preservation research. The $3 million gift to the hospital's Stanley Manne Children's Research Institute comes from the Mary and Ralph Gesualdo Family Foundation. $2 million will be used to directly support key research initiatives, and the remaining $1 million will establish the Gesualdo Family Research Scholar which will be an endowed position supporting the recruitment of a PhD scientist who is dedicated to advancing research in the field of fertility and hormone preservation and restoration.

Ann & Robert H. Lurie Children's Hospital of Chicago is celebrating a multimillion-dollar donation that will help advance fertility and hormone preservation research. The $3 million gift to the hospital's Stanley Manne Children's Research Institute comes from the Mary and Ralph Gesualdo Family Foundation. $2 million will be used to directly support key research initiatives, and the remaining $1 million will establish the Gesualdo Family Research Scholar which will be an endowed position supporting the recruitment of a PhD scientist who is dedicated to advancing research in the field of fertility and hormone preservation and restoration.

Dr. Yanina Pasikhova, Infectious Diseases Pharmacist at Moffitt Cancer Center and Research Institute, presents a talk on three lesser well known adverse drug effects involving antimicrobials. Dr. Pasikhova discusses the link between voriconazole and bone pain, the association between posaconazole and refractory hypertension and hypokalemia, and the neurological effects of of metronidazole therapy. Clinical pearls are provided for each interaction discussed.

"There is no one magic test for brain health,” says Richard Isaacson, MD.    Isaacson is a Harvard-trained neurologist who directs the Precision Prevention Program at Atria Health and Research Institute and founded the world's first Alzheimer's Prevention Clinic at Weill Cornell Medicine/NewYork-Presbyterian. A leader in precision-medicine approaches to Alzheimer's risk reduction, he has served as principal investigator for multiple research initiatives focused on individualized care. He recently led an NIH-funded clinical trial showing that a free online tool (RetainYourBrain.com) reduced Alzheimer's risk by 16% in six months, and is working to democratize brain health testing through an at-home, lower-cost blood biomarker test (AlzLabs.org). Show notes: 00:00 - What we don't know about Alzheimer's 04:49 - Where to start with Alzheimer's risk 06:55 - Lifestyle first: optimizing what you can control 10:39 - Using wearables & health tech for brain health 16:19 – Why there's no perfect blood test for the brain 29:06 - Cutting through the information noise 31:10 - Steps to take when symptoms appear 35:37 - Is it actually memory loss? 38:54 - The future of Alzheimer's testing Referenced in the episode:  Free cognitive risk & assessment tools: retainyourbrain.com Free information about blood biomarkers: ind.org/bloodtest   Free information about home testing: alzlabs.org We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: podcast@mindbodygreen.com. Learn more about your ad choices. Visit megaphone.fm/adchoices

Professor Dennis Hoffman joined Bruce & Gaydos and shared his thoughts on the U.S. jobs report and how A.I. could impact the job market in the future.

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"Fear is a response, but the ability to move forward through that fear is a decision." - Luke Rosen In the FOX Nation special Hope Starts Here: Murdoch Children's Research Institute, Benjamin connects with three incredible families battling a rare childhood disease alongside scientists at the institute. Luke Rosen, whose young daughter Susannah was diagnosed with KIF1A, shares his family's journey of hope and the immense support from their community.  Luke also reflects on finding the resilience to move forward, how his family manages Susannah's care, and his young son's remarkable strength and compassion for his little sister. Watch Hope Starts Here: Murdoch Children's Research Institute exclusively on FOX Nation! Learn more about your ad choices. Visit podcastchoices.com/adchoices

Where science meets patient care Science, innovation, and patient care all come together in this fascinating conversation with Angie Cooper, Director of Research Business Development at the HonorHealth Research Institute in Scottsdale. With more than 20 years of experience in neuroscience, clinical trials, and military medicine, Angie shares how groundbreaking research moves from idea to impact — from the future of clinical research to the human side of discovery.

In this episode of the Society of Actuaries Research Insights Podcast, Dale Hall, Managing Director of Research at the SOA Research Institute, speaks with the winning team of the 2026 Student Research Case Study Challenge from the University of New South Wales in Kensington, Australia: Vihaan Jain, Sarina Truong, Carol Zhang, Liya Ruan and Alan Steny. They are joined by Lisa Schilling, Director of Practice Research, who shares perspective on the development and coordination of the annual challenge. The conversation highlights how the winning team formed, what they learned from the experience, how they balanced the challenge with coursework and how they navigated the rigor of the competition. Listeners will also hear advice for future participants and gain insight into the volunteer-led effort behind the Student Research Case Study Challenge. Learn more about the SOA Research Institute's Student Research Case Study Challenge by visiting SOA.org, navigating to the Research Institute section and selecting Research Opportunities. There, listeners can explore finalist papers, participating teams, submissions and challenge materials.

How could the second-largest school district in the nation believe its decision to ban screens was right when so many educators adamantly believe it's wrong? How are school boards and educators looking at the same research and arriving at different conclusions? The discussion around screen use in schools has intensified, particularly with the LA Unified School District's decision to impose a screen ban. But what does this mean for our students and their educational experience? In this conversation, we'll unravel the rationale, the existing research on technology use in education, and how we can approach technology to enhance learning rather than hinder it. Dr.Punya Mishra (punyamishra.com) is Associate Dean of Scholarship and Innovation at the Mary Lou Fulton Teachers College at Arizona State University. He has an undergraduate degree in Electrical Engineering, two Master's degrees in Visual Communication and Mass Communications, and a Ph.D. in Educational psychology. He co-developed the TPACK framework, described as “the most significant advancement in technology integration in the past 25 years.” Dr. Caroline Fell Kurban is the advisor to the Rector at MEF University. She was the founding Director of the Center of Research and Best Practices for Learning and Teaching (CELT) at MEF University and teaches in the Faculty of Education. She holds a BSc in Geology, an MSc in TESOL, an MA in Technology and Learning Design, and a PhD in Applied Linguistics. Fell Kurban is currently the head of the Global Terminology Project and the creator of the GenAI-U technology integration framework. Dr. Liz Kolb is a clinical professor at the University of Michigan and the author of several books, including Cell Phones in the Classroom and Help Your Child Learn with Cell Phones and Web 2.0. Kolb has been a featured and keynote speaker at conferences throughout the U.S. and Canada. She created the Triple E Framework for effective teaching with digital technologies. Dr. Puentedura is the Founder and President of Hippasus, a consulting practice focusing on transformative applications of information technologies to education. He has implemented these approaches for over thirty years at various K-20 institutions and health and arts organizations. He is the creator of the SAMR model for selecting, using, and evaluating technology in education and has guided multiple projects worldwide. Dr. Helen Crompton is the Executive Director of the Research Institute for Digital Innovation in Learning at ODUGlobal and Professor of Instructional Technology at Old Dominion University. Dr. Crompton earned her Ph.D. in educational technology and mathematics education from the University of North Carolina at Chapel ill. Dr. Crompton is recognized for her outstanding contributions and is on Stanford's esteemed list of the world's Top 2% of Scientists. She is the creator of the SETI framework.

Professor Dennis Hoffman joined Bruce & Gaydos and shared his analysis of the U.S. economy growing at a 2 percent pace in the first three months of the year.

Dr Sami Alanne, DMus, music therapist, training psychotherapist, psychoanalyst, is an Adjunct/Associate Professor of music therapy and a researcher at the University of the Arts Helsinki. His studies include traumas, refugeeism, mental health, psychoanalysis, and psychotherapy relating to music, culture, philosophy, and society. He is the author of the books The Theory and Practice of Psychodynamic Music Psychotherapy (Barcelona Publishers) and Music, Music Therapy and Refugees: Aspects of Trauma (Palgrave Macmillan). Dr Alanne graduated as a music therapist at the Sibelius Academy in 1999 and the Master of Philosophy in music therapy at the University of Jyväskylä in 2001. He has worked in music therapy and mental health fields for over 30 years. As a music therapist and a psychotherapist, he has worked with children, adolescents, their families, and adult clients providing individual and group therapy at his private practice and health care company Apollo Terapiapalvelut (Apollo Therapy Services) in Helsinki. Besides his clinical work, during his career Alanne has been actively teaching, supervising, doing research, project work, and media appearances relating to music therapy, psychotherapy, health care, social welfare, and mental health services. In 2010, Alanne was awarded the title of Doctor of Music at the Sibelius Academy. His published dissertation was Music Psychotherapy with Refugee Survivors of Torture. In 2011, Alanne graduated as a psychodynamic music psychotherapist at the University of Oulu, and in 2013, as a trainer psychotherapist in music psychotherapy at the University of Oulu, Faculty of Medicine. After his special advanced level training of music psychotherapy at the University of Oulu in Finland, Alanne published another monograph Musiikkipsykoterapia (2014) in Finnish that was a study of psychodynamic music therapy theory, methods, and research. Since then, Dr Alanne continued his research and teaching of music therapy and psychotherapy: He has published several peer-reviewed scientific articles and books and presented them at multiple international conferences. During 2017–2019, he was a member of specialist group and project PALOMA (Developing National Mental Health Policies for Refugees at the National Institute for Health and Welfare in Finland. In 2021, Alanne was awarded with a Title of Docent in music therapy (Adjunct/Associate Professor) indicating high level research and teaching competence at the University of the Arts Helsinki (Uniarts Helsinki), and Uniarts Helsinki`s Sibelius Academy, and CERADA (The Center for Educational Research and Academic Development in the Arts). After that he has also worked as a visiting researcher at the Uniarts Helsinki`s Research Institute. In 2022, Dr Alanne graduated as a psychoanalyst and a trainer psychotherapist at the Therapeia Institute and the University of Helsinki, Faculty of Medicine. References   Alanne, S. (2010). Music Psychotherapy with Refugee Survivors of Torture. Interpretations of Three Clinical Case Studies. Sibelius Academy, Music Education Department, Studia Musica 44. Alanne, S. (2014). Musiikkipsykoterapia. Teoria ja käytäntö. [Music Psychotherapy. Theory and Practice.] Acta Universitatis Ouluensis D Medica 1248. Alanne, S. (2023). The Theory and Practice of Psychodynamic Music Psychotherapy. Dallas, TX: Barcelona Publishers. Alanne, S. (2025). Music, Music Therapy, and Refugees: Aspects of Trauma. Cham: Palgrave Macmillan.

A paediatrician says misinformation about childhood vaccines coming out of the United States has led to a huge spike in vaccine hesitancy in Australia in the past year. Professor Margie Danchin from the Murdoch Children's Research Institute says the latest figures show Australia has the lowest vaccine coverage for children under 5 in more than a decade, with the rates falling each year since 2020. She spoke with Greg Dyett.

Today we take a closer look at the mission behind the Noble Research Institute and what it means for the future of ranching in the United States. Steven Rhines, CEO and President of the Noble Research Institute, joins us to share the history of the organization, the vision that shaped it in the 1940s, and how that work continues today through a focus on soil health, grazing management, and keeping ranchers on the land. We discuss the challenges facing U.S. grazing lands, the loss of producers, and why the conversation has shifted from growth to preservation. Then, we break down four key deworming concepts designed to slow resistance and improve the effectiveness of your parasite control program—practical strategies every producer should be thinking about with Dr. Jody Wade (Boehringer Ingelheim).  #workingranchmagazine #WorkingRanchRadio #ranchlife #ranching #beef #cattle #livestock #cowcalf #cattlemanagement #ranchprofitability #grazingmanagement #soilhealth #landstewardship #foragemanagement #ranchers #parasitecontrol #cattlehealth #deworming #Neogen #FlyControl #Altosid #Cargill #NoFence #CLS

In this insightful interview, Suhag Shukla speaks with Joel Finkelstein from the Network Contagion Research Institute. They discuss the spread of anti-Indian and anti-Hindu hate online, the shift from policy debate to radicalized rhetoric, and strategies for community resilience. Discover how digital tribalism fuels misinformation and what communities can do to foster understanding and safety.Read more: https://networkcontagion.us https://networkcontagion.us/reports/from-policy-drift-to-purity-grift-how-a-small-network-hijacked-the-immigration-debate/Chapters00:00 Introduction to Digital Tribalism and Hate Speech02:47 From Policy Drift to Purity Grift05:55 The Role of Social Media in Amplifying Hate08:58 Understanding the Immigration Debate and Its Impact11:45 Cultural Contributions of the Indian Community14:43 The Generational Shift in Community Engagement17:41 Recurring Tropes in Anti-Indian Sentiment20:38 The Intersection of Anti-Indian and Anti-Semitic Rhetoric23:34 The Political Pendulum and Its Effects on Hate Speech26:32 The Need for Community Awareness and Action29:26 Proactive Solutions for Addressing Hate32:36 Conclusion and Call to ActionKeywordsdigital tribalism, hate speech, anti-Indian hate, social media influence, community resilience, misinformation, immigration debate, online extremism, social media algorithms, community building Hosted on Acast. See acast.com/privacy for more information.

In this insightful interview, Suhag Shukla speaks with Joel Finkelstein from the Network Contagion Research Institute. They discuss the spread of anti-Indian and anti-Hindu hate online, the shift from policy debate to radicalized rhetoric, and strategies for community resilience. Discover how digital tribalism fuels misinformation and what communities can do to foster understanding and safety.Read more: https://networkcontagion.us https://networkcontagion.us/reports/from-policy-drift-to-purity-grift-how-a-small-network-hijacked-the-immigration-debate/Chapters00:00 Introduction to Digital Tribalism and Hate Speech02:47 From Policy Drift to Purity Grift05:55 The Role of Social Media in Amplifying Hate08:58 Understanding the Immigration Debate and Its Impact11:45 Cultural Contributions of the Indian Community14:43 The Generational Shift in Community Engagement17:41 Recurring Tropes in Anti-Indian Sentiment20:38 The Intersection of Anti-Indian and Anti-Semitic Rhetoric23:34 The Political Pendulum and Its Effects on Hate Speech26:32 The Need for Community Awareness and Action29:26 Proactive Solutions for Addressing Hate32:36 Conclusion and Call to ActionKeywordsdigital tribalism, hate speech, anti-Indian hate, social media influence, community resilience, misinformation, immigration debate, online extremism, social media algorithms, community building Hosted on Acast. See acast.com/privacy for more information.

The seekers in these stories travel through worlds both ancient and modern, worlds of symbol and fantastical allegory, on their paths to greater truth. The state of Maharashtra is famous for its ancient Buddhist cave complexes. It's also known as the birthplace of leaders in the struggle against caste oppression: Jyotirao and Savitribai Phule in the early 1800s, and B. R. Ambedkar in 1891. It is here that Dr. Ambedkar, architect of the Indian constitution and warrior against the practice of untouchability, led marches for the right of Dalit people to draw water from community wells, to enter temples, to live with dignity. The Seekers (Blaft Publication, 2025) consists of five stories that hold Phule-Ambedkarite thought at their core, weaving together the history of ideological conflict, the pursuit of artistic excellence, and the unquenchable human thirst for freedom. The book tells of ancient revelations, of flood and fire, of vast deadly deserts, of people turned to stone. It is a unique work of anti-caste Marathi literature that feels both timeless and sparklingly new. "...Gautamiputra's stories shun the beaten path, chart their own course, and leave indelible footprints for others to follow" —Raja Dhale (1940-2019), writer and activist, co-founder of the Dalit Panthers Gautamiputra Kamble is an award-winning Marathi writer. His background in literature and philosophy informs his interests and activism—he is the editor of Secular Vision magazine, coordinator of the Secular Art Movement, and President of the Secular Movement and Secular Education and Research Institute, Sangli, Maharashtra. He has also served as the President of Phule-Ambedkar Shahu Teachers Association, Kolhapur. Parivrajak (The Seekers) was first published in Marathi in 2004; it has featured in curricula for post-graduate courses and civil service examinations in Maharashtra. Sirus Libeiro is a translator based in Mumbai. The Seekers is his first full length translation in print. He has a background in Economics and Urban Studies. He is currently working on a translation of 'Jayanti' (2022), Gautamiputra Kamble's second fiction novel. You can order the pdf copy of this book here for $5.32. This collection of short stories is perfect for undergraduate classroom teaching.  Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/new-books-network

The seekers in these stories travel through worlds both ancient and modern, worlds of symbol and fantastical allegory, on their paths to greater truth. The state of Maharashtra is famous for its ancient Buddhist cave complexes. It's also known as the birthplace of leaders in the struggle against caste oppression: Jyotirao and Savitribai Phule in the early 1800s, and B. R. Ambedkar in 1891. It is here that Dr. Ambedkar, architect of the Indian constitution and warrior against the practice of untouchability, led marches for the right of Dalit people to draw water from community wells, to enter temples, to live with dignity. The Seekers (Blaft Publication, 2025) consists of five stories that hold Phule-Ambedkarite thought at their core, weaving together the history of ideological conflict, the pursuit of artistic excellence, and the unquenchable human thirst for freedom. The book tells of ancient revelations, of flood and fire, of vast deadly deserts, of people turned to stone. It is a unique work of anti-caste Marathi literature that feels both timeless and sparklingly new. "...Gautamiputra's stories shun the beaten path, chart their own course, and leave indelible footprints for others to follow" —Raja Dhale (1940-2019), writer and activist, co-founder of the Dalit Panthers Gautamiputra Kamble is an award-winning Marathi writer. His background in literature and philosophy informs his interests and activism—he is the editor of Secular Vision magazine, coordinator of the Secular Art Movement, and President of the Secular Movement and Secular Education and Research Institute, Sangli, Maharashtra. He has also served as the President of Phule-Ambedkar Shahu Teachers Association, Kolhapur. Parivrajak (The Seekers) was first published in Marathi in 2004; it has featured in curricula for post-graduate courses and civil service examinations in Maharashtra. Sirus Libeiro is a translator based in Mumbai. The Seekers is his first full length translation in print. He has a background in Economics and Urban Studies. He is currently working on a translation of 'Jayanti' (2022), Gautamiputra Kamble's second fiction novel. You can order the pdf copy of this book here for $5.32. This collection of short stories is perfect for undergraduate classroom teaching.  Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/buddhist-studies

The seekers in these stories travel through worlds both ancient and modern, worlds of symbol and fantastical allegory, on their paths to greater truth. The state of Maharashtra is famous for its ancient Buddhist cave complexes. It's also known as the birthplace of leaders in the struggle against caste oppression: Jyotirao and Savitribai Phule in the early 1800s, and B. R. Ambedkar in 1891. It is here that Dr. Ambedkar, architect of the Indian constitution and warrior against the practice of untouchability, led marches for the right of Dalit people to draw water from community wells, to enter temples, to live with dignity. The Seekers (Blaft Publication, 2025) consists of five stories that hold Phule-Ambedkarite thought at their core, weaving together the history of ideological conflict, the pursuit of artistic excellence, and the unquenchable human thirst for freedom. The book tells of ancient revelations, of flood and fire, of vast deadly deserts, of people turned to stone. It is a unique work of anti-caste Marathi literature that feels both timeless and sparklingly new. "...Gautamiputra's stories shun the beaten path, chart their own course, and leave indelible footprints for others to follow" —Raja Dhale (1940-2019), writer and activist, co-founder of the Dalit Panthers Gautamiputra Kamble is an award-winning Marathi writer. His background in literature and philosophy informs his interests and activism—he is the editor of Secular Vision magazine, coordinator of the Secular Art Movement, and President of the Secular Movement and Secular Education and Research Institute, Sangli, Maharashtra. He has also served as the President of Phule-Ambedkar Shahu Teachers Association, Kolhapur. Parivrajak (The Seekers) was first published in Marathi in 2004; it has featured in curricula for post-graduate courses and civil service examinations in Maharashtra. Sirus Libeiro is a translator based in Mumbai. The Seekers is his first full length translation in print. He has a background in Economics and Urban Studies. He is currently working on a translation of 'Jayanti' (2022), Gautamiputra Kamble's second fiction novel. You can order the pdf copy of this book here for $5.32. This collection of short stories is perfect for undergraduate classroom teaching.  Learn more about your ad choices. Visit megaphone.fm/adchoices Support our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/south-asian-studies

How does one man's dedication to community health reshape cancer prevention efforts in Texas? Carlton Allen's passion for public health and population health, sparked during his academic years, led him to an influential role in the Cancer Prevention and Research Institute of Texas (CPRIT). Through his guidance, CPRIT addresses significant cancer burdens and health disparities statewide. Meanwhile, Allen champions the Texas Cancer Plan as a comprehensive roadmap for continued progress in cancer prevention and care. Key Questions Answered 1. How did Carlton Allen get into public health? 2. What differentiates public health from direct patient care according to Carlton? 3. Where did Carlton Allen complete his education? 4. How did Carlton Allen integrate community health workers (CHWs) into clinical operations? 5. What are the challenges in obtaining funding for community health workers? 6. What is the Cancer Prevention Research Institute of Texas (CPRIT) and what roles does it play? 7. How does CPRIT impact cancer prevention and research in Texas? 8. What frustrations does Carlton Allen face in his role at CPRIT? 9. What was Carlton Allen’s role in the Texas Cancer Plan? 10. What values does Carlton hope to instill in his children based on his community work? Timestamped Overview 00:00 Community Health Workers' Impact 03:42 Healthcare Worker Reimbursement Challenge 07:46 Expanding Healthcare Outreach with Grants 10:07 Visiting Texas Prevention Grantees 13:27 Advancements in Cancer Prevention 16:51 Cancer Secrecy in Males 21:14 Inclusive Cancer Care Guidelines 25:57 Community Engagement and Volunteerism 27:56 Raising Hardworking, Community-Minded Children Learn more about CPRIT here. Support The Rose HERE. Subscribe to Let’s Talk About Your Breasts on Apple Podcasts, Spotify, iHeart, and wherever you get your podcasts.See omnystudio.com/listener for privacy information.

How many wolves is enough? Is that even the right question to ask? And will the recent lowering of wolf protection status in the EU actually reduce the conflict between wolves and people? These are some of the questions we tackle in this episode. After the previous wolf episode generated a lot of feedback, including detailed emails from scientists, one of those scientists is our guest today. Joachim Mergeay is a senior researcher at the Research Institute for Nature and Forest in Belgium, an associate professor of conservation genetics at Leuven University, Flanders, and a member of the IUCN Large Carnivore Initiative for Europe. He reached out after listening to the podcast and I was immediately interested in his deeper perspective on wolf coexistence in Europe.During our conversation, Joachim makes a compelling case that if we solve the conflict, the number of wolves becomes far less important. He shares practical examples from Belgium where electric fencing, supported by volunteer teams and full subsidies for farmers, has virtually eliminated livestock predation in some wolf territories. We also discuss why shooting wolves, even under the new lowered protection status, is unlikely to meaningfully reduce conflict because the requirement to maintain favourable conservation status leaves very little room for lethal management. Joachim is clear that he is not against hunting in principle but stresses that we need to be honest about the goals behind it.We also get into the broader picture of rural abandonment, shifting baselines and the urban-rural divide. Joachim challenges the assumption that rural and urban people are worlds apart in their attitudes towards wolves, pointing to research showing the differences are smaller than most of us think. He also offers an optimistic observation about shifting baselines working in the opposite direction for once, with children growing up in countries where wolves are simply part of the landscape. We finish with a look at how European-level policy can work alongside local solutions and what the future might hold for wolf populations across the continent.Further reading:Perspectives on wolves after their recolonisation in Flanders, BelgiumContinuing recovery of wolves in EuropeEstimating the Effective Size of European Wolf PopulationsSubscribe to Tommy's Outdoors: Conservation and Science NewsletterSupport the Podcast and Buy Me a Coffee.Follow Tommy's Outdoors on Bluesky, Instagram or YouTube

The Rao Lab at Seattle Children's Research Institute developed a three-dimensional (3D) tissue-engineered model of osteosarcoma to investigate the effects of the extracellular matrix on malignant cell function. The study demonstrated that culturing osteosarcoma (OS) cells within a 3D collagen matrix induced unique cellular responses, altered morphology, enhanced tumorigenic behavior, and reduced chemosensitivity compared to cells cultured in 2D collagen or on standard tissue culture plastic. They identified overexpression of drug efflux pumps as a key mechanism of chemoresistance and further showed that a tyrosine kinase inhibitor could suppress drug efflux activity, thereby enhancing the efficacy of standard chemotherapeutic agents.While this earlier study examined the effects of a single collagen concentration on osteosarcoma phenotype, clinical solid tumors are characterized by altered extracellular microarchitecture, including increased matrix density and stiffness. These changes restrict drug transport and limit chemotherapy-induced cell death.Dr. Rao will present findings from engineered tumor models incorporating varying matrix densities and demonstrate how matrix density influences osteosarcoma function. This work was funded by the 2025 Outsmarting Osteosarcoma Young Investigator Hope Award.Dr. Rao is a Pediatric Hematologist Oncologist at the Seattle Children's Hospital and a Principal Investigator in the Ben Towne Center for Childhood Cancer and Blood Disorders Research at the Seattle Children's Research Institute. His lab harnesses biomaterials and tissue engineering technologies to design 3D models of osteosarcoma to understand how cell-matrix interactions lead to chemoresistance.

Forty years at The Rose taught our co-founder and CEO Dorothy Gibbons this: you don’t walk away from women, even when the system does. In this farewell episode, Dorothy share the stories that shaped her, why she's stepping back, and why your support and your stories still matter. Support The Rose HERE. Subscribe to Let’s Talk About Your Breasts on Apple Podcasts, Spotify, iHeart, and wherever you get your podcasts. Key Questions Answered 1. How were Dorothy and Dr. Dixie received as two women creating a new breast health nonprofit in the mid‑1980s? 2. What kind of resistance did Dorothy encounter from male‑dominated leadership when she pushed for mammograms and a place for uninsured women? 3. Who were early patients and volunteers like Annabelle and Diana, and how did they shape The Rose’s culture? 4. Why does Dorothy believe patient stories—and hearing “someone else has been there”—still matter just as much as technology? 5. What does it mean for The Rose to be a Breast Imaging Center of Excellence, and why was that accreditation such a milestone? 6. Which values at The Rose are non‑negotiable for Dorothy, especially around how women and working mothers are treated? 7. What has truly improved in breast cancer imaging, awareness, and treatment in 40 years—and what has barely changed for uninsured and low‑income women? 8. How did gifts ranging from one dollar at a gas station to a surprise million‑dollar donation keep The Rose going? 9. After four decades, how does Dorothy keep her passion for women’s health, and what unfinished business does she believe belongs to the next generation? 10. What advice does she give anyone starting a nonprofit today—and why does she insist real change requires policy change, not just good programs? Timestamped Overview 1:00 Dorothy reflects on starting The Rose and how little the world understood mammograms and uninsured women in the mid‑1980s. 02:00 Stories of early skepticism, male‑dominated rooms, and how Dr. Dixie’s trailblazing surgical career gave them cover to push forward. 05:30 Remembering first patients and volunteers like Annabelle and Diana, their opposite personalities, and how they taught Dorothy there’s no one “right” way to live with cancer. 08:30 Why sharing patient stories on the podcast still matters: faith, courage, and the power of hearing your own experience in someone else’s words. 10:20 What becoming a Breast Imaging Center of Excellence required from staff, physicians, and equipment—and why that recognition mattered. 12:40 Dorothy’s non‑negotiables: valuing women, backing employees as whole people, and the day a tone‑deaf salesman lost a contract with one sexist comment. 15:40 What has improved in imaging, awareness, and treatment over 40 years—and what remains broken for uninsured and low‑income women. 18:00 The emotional toll of fundraising shortfalls, policy stagnation, and why closing the doors never felt like an option. 19:30 How advocacy and policy wins like Texas’s Cancer Prevention and Research Institute funding changed the landscape for prevention and research. 21:30 The unforgettable million‑dollar donor in overalls and the equally powerful one‑dollar gift at a gas station in El Paso. 24:00 Sponsored patients who gave back, like the woman who saved for years to fund another biopsy, and how those gifts shaped Dorothy’s view of generosity. 25:30 Keeping passion after four decades, why 40 years went by in a blink, and the stories that still fuel Dorothy’s work. 26:30 Letting The Rose “grow up,” what kind of energy Dorothy hopes to leave behind, and why she believes in the quiet power of “you can do it.” 28:00 Life after pink: how Dorothy imagines her next chapter and her advice for anyone bold enough to launch a nonprofit today.See omnystudio.com/listener for privacy information.

Greg Kelly, CEO of STV, and Vice Chair of the ACEC Research Institute appeared on WTBQ-AM in New York to discuss the Institute's new research on the national shortage of engineers.  The shortage is being driven by a combination of retirements, visa limits for international graduates, and a shrinking recruitment pipeline. Greg explains how firms use internships, mentorship, and competitive salaries to attract new talent. The conversation covers how AI will augment—not replace—engineers, the importance of human judgment in safe design, and the lasting legacy of infrastructure projects that connect communities. Resources such as ACEC scholarships and outreach to schools are highlighted as practical steps to grow and diversify the next generation of engineers. 

This month we were honored to sit down with Professor Ortwin Renn to talk about the concept of polycrisis. Ortwin works with the World Academy Info Hub, Existential Threats and Risks to All InfoHub (EXTRA), as the Director of Systemic Risk Research. This episode is the second produced in collaboration with the join EXTRA/EXALT webinar “Is Extractivism a Prime Cause of the Polycrisis?” (see link below). Ortwin is social scientist focusing on risk governance who has had a long and storied career. Currently, he serves as a professor emeritus for environmental sociology and technology assessment at the University of Stuttgart and directs the non-profit company DIALOGIK, a research institute for the investigation of communication and participation processes. In our conversation we talk about sustainable practices and how they can be implemented in society. We start our conversation with how Ortwin got involved with sustainability and how he discovered his interest in social movements and particularly why people get involved in social movements, especially focuses on technology and how there can be a livable co-evolution between nature and society. Ortwin shared that one of the biggest developments he has seen over his career is that it used to feel like we were facing one crisis at a time, while today is feels like there are multiple, interconnected crisis. Join us for this insightful conversation on polycrisis and its existential and practical implications!Want to learn more about Ortwin's academic work? See:His profile at the Research Institute for Sustainability https://www.rifs-potsdam.de/en/people/ortwin-renn and the non-profit DIALOGIK https://www.dialogik-expert.de/en Want to learn more about his work at the World Academy? Check out the EXTRA website. https://worldacademy.org/extra/ Want to check out the webinar co-hosted by EXTRA and EXALT, “Is Extractivism a Prime Cause of the Polycrisis?” You can find it on the EXTRA YouTube channel. https://youtu.be/emyOYEh2oZQ?si=dxkaNNIjWcqInwfP

In this special episode recorded live on site at SXSW EDU, Dustin chats with Tanner Jackson from ETS. He explains the ways his team integrates AI and why transparency is increasingly important for edtech companies to foster. Tanner also highlights the recently launched Center for Responsible AI that ETS created as a new resource for higher ed leaders. Guest Name: Dr. Tanner Jackson, Head of AI Products, ETS Guest Social: LinkedIn Guest Bio: Tanner Jackson is the Head of AI Products at ETS, overseeing the development and deployment of AI capabilities across the global enterprise. His work spans two core areas: integrating AI into product and platform development, and building scalable AI solutions that deliver measurable business and/or educational impact.  With over a decade of experience at ETS-including roles in the Research Institute, Language Learning and Assessment Business, and the Office of the CEO-Tanner's work has consistently focused on helping people achieve their potential. A respected voice on AI, Tanner is a sought-after speaker at top industry forums, including the SHRM Talent Annual Conference, Zoom Educator Summit, and ASU+GSV and has been featured in The Chronicle of Higher Education and Education Week as a subject matter expert. - - - -Connect With Our Host:Dustin Ramsdellhttps://www.linkedin.com/in/dustinramsdell/About The Enrollify Podcast Network:The Higher Ed Geek is a part of the Enrollify Podcast Network. If you like this podcast, chances are you'll like other Enrollify shows too!Enrollify is made possible by Element451 — The AI Workforce Platform for Higher Ed. Learn more at element451.com. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The Walton Institute at South East Technological University (SETU) is marking 30 years of ICT research and innovation and five years as a recognised research institute, highlighting three decades of collaboration with more than 800 partners worldwide on projects worth over €485 million. Marking this milestone in the same year that Ireland assumes the EU Council Presidency underscores the importance of research institutes such as Walton in contributing to European innovation, technology development and cross-border collaboration. For thirty years, the Walton Institute for Information and Communication Systems Science has played an important role in advancing communications and digital technologies. Since its establishment as the Telecommunications Software and Systems Group (TSSG) in 1996, the institute has secured more than €155 million in competitive research funding while working with partners across industry, government and academia. Professor Marie Claire Van Hout, Vice President for Research, Innovation and Impact, SETU, says "Walton Institute plays a central role in SETU's research and innovation ecosystem and in strengthening Ireland's international research presence. Its work demonstrates how a technological university can connect research excellence with regional innovation and global collaboration.'' Led by Executive Director Dr Kevin Doolin and Director of Research Dr Deirdre Kilbane, Walton has built a strong international reputation for both fundamental research and applied innovation. Since its designation as a Research Institute in 2021, it has strengthened industry collaboration and grown its research capacity across several strategic technology domains. Dr Kevin Doolin, Executive Director, Walton Institute, SETU, joined the team in 2004 and has seen the growth of Walton over the years. "What began as a telecommunications research group in Waterford has grown into an international research institute working with organisations across Europe and beyond. Our focus has always been on turning research into practical outcomes that support industry innovation and economic growth in the region." Today, the institute comprises more than 80 students, postdocs, research scientists and engineers, and maintains an active collaboration network across 60 countries. Its work spans several key technology areas, including artificial intelligence, future communications networks, quantum communications, smart energy, digital health, smart cities, agri-tech and immersive technologies. Walton is particularly recognised for its expertise in AI systems, advanced communications networks and digitalisation, supporting organisations to adopt new digital technologies and move research outcomes from the laboratory into practical use. Strengthening Ireland's research, infrastructure and innovation ecosystem Walton continues to play an important role in national innovation programmes supporting digital transformation across industry and public services. This includes the Enterprise Ireland ICS Technology Gateway and the ENTIRE European Digital Innovation Hub, where researchers work with SMEs, public sector organisations and multinational companies to test and deploy emerging digital technologies. The institute also maintains strong engagement with European research initiatives. Walton researchers currently participate in 20 strategic European research clusters, contributing to discussions that help shape technology policy and research priorities at the EU level. In 2025, the university was recognised as Ireland's leading technological university for Horizon Europe funding, securing almost €13 million to date, along with over €11.5 million for the EuroQCI Initiative. As Ireland prepares to lead the Council of the European Union, this level of participation demonstrates the contribution Irish research institutes make to Europe's digital and innovation agenda. Building talent and global careers from the south east The success of the Walton I...

Daniel Turp is a Canadian legal scholar and prominent Quebec sovereigntist. He is an emeritus and associate professor at the Université de Montréal's Faculty of Law, where he has taught advanced constitutional law and public international law since 1982. A former Bloc Québécois MP for Beauharnois—Salaberry (1997–2000) and Parti Québécois MNA (2003–2008), Turp is a leading advocate for Quebec independence, arguing its legal basis under Canadian and international law. He also serves as president of the Québec Association of Constitutional Law and the Research Institute on the Self-Determination of Peoples and National Independence (IRAI).Silver Gold Bull Links:Website: https://silvergoldbull.ca/Email: SNP@silvergoldbull.comText Grahame: (587) 441-9100Bow Valley Credit UnionBitcoin: www.bowvalleycu.com/en/personal/investing-wealth/bitcoin-gatewayEmail: welcome@BowValleycu.com Get your voice heard: Text Shaun 587-217-8500

A $25 million wire transfer. A fake CFO. An entire executive team that didn't exist. This is what modern cybercrime looks like — and your firewall won't stop it. In this episode of The Audit, co-hosts Joshua Schmidt, Eric Brown, and Nick Mellum sit down with James McDowell — forensic psychology expert, cybercrime researcher, and adjunct professor at American Military University — to explore the chilling intersection of AI, human psychology, and cybercrime. James introduces the concept of "cognitive surrender": the slow, dangerous transfer of our thinking to AI tools, and how threat actors are exploiting it at scale. What You'll Learn: What "cognitive surrender" is and why it's cybercrime's greatest accelerant How a $25M deepfake scam bypassed every red flag a trained employee had The psychology behind System 1 vs. System 2 thinking — and why attackers time their strikes around your lunch break Why voice passwords and family code phrases are becoming critical security tools How FraudGPT and dark-web AI models are lowering the barrier for cybercriminals What James's wave theory reveals about how we trust — and how that trust gets exploited 

We delve into research into UV light treatment for powdery mildew with Dr Paul Epee at the Bragato Research Institute (BRI) in Marlborough, New Zealand.

Send us Fan MailWe love discussing oral systemic health, so we could not be more excited to chat with Anne O. Rice on this week's episode

Dr. Jason Thacker, Director of the Research Institute at The Southern Baptist Theological Seminary and a leading voice on human dignity, ethics, and culture, joins us to open Psalm 8 and help us recover a distinctly biblical vision of what it means to be human. In a cultural moment where personhood, value, and moral worth are often treated as fluid, developmental, or dependent on ability, autonomy, or usefulness, Dr. Thacker reminds us that Scripture grounds our dignity not in what we do, what others think of us, or what we contribute, but in the God who created us, knows us, and crowns humanity with glory and honor. Walking carefully through Psalm 8, he shows how our understanding of ourselves can never be separated from our understanding of God as Creator, Sustainer, and Lord, and how our calling as image bearers flows from His majesty rather than our own self-definition.Our dignity is secure because it is rooted not in ourselves, but in the majesty of the God who made us.

Czy Polska, wzorem Australii, powinna odciąć dzieci i młodzież od serwisów społecznościowych? Czy mamy całkowitą pewność, że będzie to dla nich dobre? Odpowiedzi na te pytania wcale nie są takie oczywiste. Ale postaramy się ich udzielić w tym odcinku. Bo tym razem sprawdzimy, jak w Australii przebiega odcięcie dzieciaków od platform społecznościowych - jak reagują na to politycy, rodzice, badacze i sami najmłodsi. Przyjrzymy się także europejskim próbom ucywilizowania sytuacji i sprawdzimy, jaki pomysł na dzieci i młodzież mają polscy politycy. GOŚCIE ODCINKA: - Susan Sawyer, profesorka pediatrii na University of Melbourne i badaczka zdrowia nastolatków w Murdoch Children's Research Institute, - Kamil Śliwowski, trener kompetencji cyfrowych, od ponad dekady działa w ruchu na rzecz otwartych zasobów wiedzy, - dr Sabrina Caldwell, ekspertka ds. etyki w technologii z University of New South Wales w Canberze, - dr Maksymilian Bielecki, współzałożyciel Obserwatorium Badań Medialnych na Uniwersytecie SWPS. NA SKRÓTY: 18:43 - Lekcja 1: polityczna skuteczność 22:12 - Lekcja 2: ewaluacja 28:09 - Lekcja 3: prywatność i weryfikacja wieku 33:38 - Lekcja 4: co na to młodzi 38:38 - Wielka Brytania i jej pomysły 45:55 - Polska i jej pomysły 55:50 - Najważniejsze lekcje ŹRÓDŁA: - o odrzuceniu przez brytyjski parlament zakazu portali społecznościowych dla użytkowników młodszych niż 16 lat: https://uk.finance.yahoo.com/news/mps-vote-reject-social-media-220240669.html - o badaniu z Bradford: https://committees.parliament.uk/writtenevidence/163429/default/ - o niewiążącym porozumieniu Parlamentu Europejskiego ws. portali społecznościowych: https://www.reuters.com/sustainability/society-equity/european-parliament-agrees-resolution-calling-minimum-age-social-media-2025-11-26/ - o planach prac PE: https://www.europarl.europa.eu/legislative-train/theme-protecting-our-democracy-upholding-our-values/file-digital-fairness-act

First up on the podcast, freelance journalist Evan Howell traveled to Cape Blossom, Alaska, where the receding coastline has revealed an ancient trove of glacial ice that may have survived for 350,000 years—making it the oldest ice in the Northern Hemisphere. Now researchers just need to figure out how to date it. Next on the show, tracking wolves and ravens in Yellowstone National Park shows the birds don't follow the wolves in hope of a meal, but instead remember and revisit frequent wolf kill sites. Matthias-Claudio Loretto, assistant professor in the Research Institute of Wildlife Ecology at the University of Veterinary Medicine Vienna, discusses how this might change the way we think about scavengers' strategies for finding their ephemeral food sources.  Finally, Claire Bedbrook, the Helen Hay Whitney and Wu Tsai neuroscience postdoctoral fellow at Stanford University, discusses her work tracking African turquoise killifish over their life span. By capturing behaviors over the course of the fish's entire lives, her team was able to observe behaviors that could be used to predict whether a fish would live a short or long life. This week's episode was produced with help from Podigy.  About the Science Podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of Home Health Revealed, Hannah Vale sits down with Alex Hartzman, Vice President of Research & Analytics at the National Alliance for Care at Home and Head of Operations at the Research Institute for Home Care, to discuss the policy, payment, and workforce trends shaping the future of home health. They explore the ongoing pressure from Medicare reimbursement changes, the impact of value-based purchasing and quality metrics, and the growing workforce challenges affecting agencies across the country. The conversation also dives into the increasing demand for home-based care, access-to-care concerns, and why the story of home health is not always reaching policymakers the way it should. If you're a home health leader trying to prepare for the years ahead, this episode offers an inside look at the data, policy conversations, and industry realities that will define the future of care at home. Listeners interested in getting involved in advocacy efforts can learn more through the National Alliance for Care at Home Advocacy Action Center and find details about Alliance membership opportunities on their website. The Alliance DC Advocacy Fly-In will take place September 13–16, and Alliance members will receive registration information directly. Chapters (00:00:03) - Home Health Revealed(00:00:25) - Alex Hartzman on Policy Influence in Home Care(00:01:27) - Top 3 issues facing home health agencies(00:05:30) - What Can an Average Home Health Agency Do to Improve Their Quality Score(00:09:37) - Risk of rehospitalization(00:10:35) - Home Health Agency Executives on Staff turnover(00:14:15) - The value of home health(00:19:49) - Home Health and Hospice: A Conversation

In this episode of The Wisdom Of ... Show, host Simon Bowen speaks with Dr Naba Alfayadh, emergency medicine doctor, social entrepreneur, Stanford-trained innovator, and Founder and CEO of Rahma Health. Naba's organisation has reached over 3 million Arabic-speaking families globally, achieved 95% parent behaviour change in under 10 minutes, and in 2025 won three simultaneous national Telstra awards, including Business of the Year. A former Iraqi refugee who fled war at age 10, Naba has built a life and an organisation at the intersection of medicine, technology, and the most foundational force she's identified in human development … love.Simon builds a live visual model, ‘The Rahma Health Behaviour Change Pathway', capturing the precise framework behind how cultural safety becomes the gateway to real, measurable transformation.Ready to apply systematic frameworks like this in your own business?Join Simon's Masterclass on The Models Method: https://thesimonbowen.com/masterclass.Episode Breakdown00:00 Welcome to The Wisdom Of ... Show and introduction of Dr Naba Alfayadh04:15 From Iraq to Australia, the refugee journey that shaped everything10:30 Founding Happy Brain Education at 22: what a student sees that institutions miss17:45 The genesis of Rahma Health and why COVID turned out to be the moment24:10 What "culturally safe" actually means and why it's a performance variable, not a value statement31:55 The behaviour change data: how 5–10 minutes produces 95% change and doubled health literacy38:20 LIVE MODEL BUILD: The Rahma Health Behaviour Change Pathway47:00 Intergenerational trauma, the precise mechanism by which conditional love becomes a survival programme55:30 Unconditional love as leadership: what the research shows and why it's not soft01:03:15 The three principles for leading across cultures: listening, respect, and love01:10:40 Kookaburra Kindness, writing a children's book with her daughter in response to the Bondi tragedy01:17:00 What it means to build something. Not to become a billionaire, but because there are things to be done.01:17:53 Closing reflections and the green lineAbout Dr Naba AlfayadhDr Naba Alfayadh is a General Practice Registrar, emergency medicine doctor, public health leader, and serial social entrepreneur whose work has supported more than three million people globally. She is the Founder and CEO of Rahma Health, an award-winning Australian charity creating culturally and psychologically safe health and parenting resources for Arabic-speaking families worldwide.Born in Iraq, Dr Alfayadh fled to Australia in 2003 at age 10 during the Iraq War, after her school was bombed. She graduated from Monash University with MBBS/BMedSci degrees on a Merit and Equity Scholarship, and later studied Social Innovation and Entrepreneurship at Stanford University. She co-founded Happy Brain Education at age 22, growing it to serve 2,000+ students with 50 staff across two states, before founding Rahma Health in 2021.Under her leadership, Rahma Health has reached over 3 million users globally, partnered with 50 international organisations, and published research with the Murdoch Children's Research Institute demonstrating that health literacy more than doubled after just 5–10 minutes of platform use, with 95% of parents reporting behaviour change. She currently serves on the Governance Committee, updating Maternity and Neonatal Handbooks for Safer Care Victoria.In 2025, Dr Alfayadh was named Telstra Business of the Year, Telstra Championing Health, and Telstra Accelerating Women - three simultaneous national awards. She also received the Women's Health Medal of Distinction Australasia 2025 and the Monash Emerging Leaders Alumni Award. She is a Westpac Social Change Fellow and a Women's Agenda Leadership Awards Finalist.Connect with Dr Naba Alfayadh: LinkedIn: https://www.linkedin.com/in/nmalfayadh/Instagram: https://www.instagram.com/myrahmahealth/Facebook: https://www.facebook.com/myrahmahealth/Website: https://rahma.health/about-rahma-health/About Simon BowenSimon has spent over two decades working with influential leaders across complex industries. His focus is on elevating thinking in organisations, recognising that success is directly proportional to the quality of thinking and ideas within a business. Simon leads the renaissance of thinking through his work with global leaders and organisations.Connect with SimonLinkedIn: https://www.linkedin.com/in/simonbowen-mm/Instagram: https://www.instagram.com/officialsimonbowen/Website: https://thesimonbowen.com/Get Simon Bowen's Personal Newsletter for Leaders, Thinkers, and Entrepreneurs!Sign Up Now: https://thesimonbowen.com/newsletter.Join Simon's Masterclass: Unlock your leadership potential with The Models Method.Learn to articulate your unique value and create scalable impact.Watch it Now: https://thesimonbowen.com/masterclass.

Manjari Jar-uhar | Advisor Security, Author, Former IPS OfficerMs. Manjari Jaruhar is one of the first five women police officers in India and the first from the state of Bihar. She has recently published her memoirs, 'Madam Sir'. It has been well received and has become a best seller. Ms. Manjari Jaruhar was a former Advisor to Tata Consultancy Services (TCS), based in New Delhi. She was the Chief Coordinator with the Indian Music Industry (IMI) and is a Senior Advisor to 9.9 Media. Recently she became Advisor to the Committee on Private Security Industry at FICCI. Ms. Manjari Jaruhar retired as Special Director General of the Central Industrial Security Force (CISF). She was selected for the Indian Police Service (IPS), the elite crime prevention and law enforcement cadre of the Indian Civil Service, in 1976 and has held positions in the State Governments of Bihar and Jharkhand, the National Police Academy (NPA), the CISF and the Central Reserve Police Force (CRPF). She has led teams in a wide range of complex and challenging assignments that have prepared her for a career in the private and social sector. From fighting crime to administering a massive organisation, Ms. Jaruhar has shown exemplary leadership in a domain traditionally dominated by men. She is the recipient of the Government of India's Police Medal for Meritorious Service and the President's Police Medal for Distinguished Service. She was awarded the Director General's Commendation Disc for outstanding service twice in the CISF and once when she was with the CRPF.Specialties: Security and protection of large undertakings, recruitment and personnel management, management of training and all gender related issuesAfter the enactment of the law on Sexual Harassment at the Work Place she has been invited frequently to share her experiences by several organizations. She also addresses on gender sensitization, safety & security and legal awareness of women.She visited Afghanistan on the invitation of OXFAM and Research Institute of Women Peace and Security, to help them understand changes and improvements required for raising an effective women police force.

Professor Hoffman joined Bruce & Gaydos to share his analysis of a report from the Labor Department that showed employers cut 92,000 jobs in February when economists expected the U.S. would continue adding jobs.

Tumor-infiltrating lymphocyte (TIL) cell therapy is a promising option for patients with advanced melanoma, but logistical and referral challenges can be a barrier to care. In this episode, CANCER BUZZ speaks with Lilit Karapetyan, MD, MS, FACP, medical oncologist at Moffit Cancer Center and Research Institute, an authorized treatment center (ATC) for TIL cell therapy, and Raju Vaddepally, MD, hematologist-oncologist at Florida Cancer Specialists, a non-ATC, about the referral process. Both guests discuss the relationship between their cancer programs, offering actionable tips on how to streamline the identification and referral of melanoma patients for TIL therapy across institutions. Guests:  Lilit Karapetyan, MD, MS, FACP Medical Oncologist Moffitt Cancer Center and Research Institute Tampa, FL Raju Vaddepally, MD   Hematologist-Oncologist Florida Cancer Specialists Naples, FL  "It is extremely important that providers think about this earlier, because the huge issue that we have with TIL therapy is that we get a lot of patients referred but unfortunately, they are no longer fit to proceed with the therapy." - Lilit Karapetyan, MD, MS, FACP "Cancer care can be so fragmented and always requires multidisciplinary input, whether it be within the town or going to an academic center, so we do have a specialized department in which they handle all these referrals." - Raju Vaddepally, MD Resources ACCC TIL Therapy Resources ACCCBuzz Blog: Streamlining TIL Cell Therapy: ACCC Resources to Improve Referral Pathways and Academic–Community Coordination CANCER BUZZ: Developments in TIL Cell Therapy  

The organ donation stories are inspiring and hopeful, but Anita Slominska says they leave out one very important part of the story. When Anita's sister was in her 20s, she was on a waitlist for a liver transplant and eventually ended up in the ICU, being kept alive by a ventilator in the hopes that a donor would be found. But, that didn't happen. Anita Slominska is now a postdoctoral researcher at the Research Institute of the McGill University Health Centre. We talk to her about her new book, about her sister's story, Other Endings: Organ Transplantation and the Burdens of Hope.

The word is spreading through the education community that a new kind of artificial intelligence enables students to complete an entire course with a single prompt. As one educator explained, with just a simple setup, a student can put an entire course on autopilot and go back to playing video games. It's called Agentic AI, and it has sparked a new round of handwringing and calls to go back to blue books and pencils. To kick off 2026, the creators of SAMR, TPACK, Triple E, SETI, and the Gen AI U frameworks met to unravel how this technology may impact teaching, learning, and the future of proving that a student's degree or credential actually indicates competence. The big takeaway is that the solutions start with asking the right questions. Follow on X: @CFKurban @hcrompton @lkolb @punyamishra @jonHarper70bd @bamradionetwork Related Resources: The AI Tech Fatigue of 2025 Was Real: How Educators Are Planning to Regain Control in 2026 | AI Agents: A New Era in Higher Education | Cheating Lessons: Learning from Academic Dishonesty | SAMR | The SETI Framework | TPACK | Triple-E | The GenAI-U Framework BRN-X: Gen AI Podcast Lab Dr. Punya Mishra (punyamishra.com) is the Associate Dean of Scholarship and Innovation at the Mary Lou Fulton Teachers College at Arizona State University. He has an undergraduate degree in Electrical Engineering, two Master's degrees in Visual Communication and Mass Communications, and a Ph.D. in Educational psychology. He co-developed the TPACK framework, described as “the most significant advancement in technology integration in the past 25 years.” Dr. Caroline Fell Kurban is the advisor to the Rector at MEF University. She was the founding Director of the Center of Research and Best Practices for Learning and Teaching (CELT) at MEF University and teaches in the Faculty of Education. She holds a BSc in Geology, an MSc in TESOL, an MA in Technology and Learning Design, and a PhD in Applied Linguistics. Fell Kurban is currently the head of the Global Terminology Project and the creator of the GenAI-U technology integration framework. Dr. Liz Kolb is a clinical professor at the University of Michigan and the author of several books, including Cell Phones in the Classroom and Help Your Child Learn with Cell Phones and Web 2.0. Kolb has been a featured and keynote speaker at conferences throughout the U.S. and Canada. She created the Triple E Framework for effective teaching with digital technologies and blogs at cellphonesinlearning.com. Dr. Puentedura is the Founder and President of Hippasus, a consulting practice focusing on transformative applications of information technologies to education. He has implemented these approaches for over thirty years at various K-20 institutions and health and arts organizations. He is the creator of the SAMR model for selecting, using, and evaluating technology in education and has guided multiple projects worldwide. Dr. Helen Crompton is the Executive Director of the Research Institute for Digital Innovation in Learning at ODUGlobal and Professor of Instructional Technology at Old Dominion University. Dr. Crompton earned her Ph.D. in educational technology and mathematics education from the University of North Carolina at Chapel ill. Dr. Crompton is recognized for her outstanding contributions and is on Stanford's esteemed list of the world's Top 2% of Scientists. She is the creator of the SETI framework. She frequently serves as a consultant for various governments and bilateral and multilateral organizations, such as the United Nations and the World Bank, on driving meaningful change in educational technology.

On this episode I sat with Lance Walker. Lance is one of the most respected human performance experts in the world — a physical therapist and coach who has trained Olympians, NFL players, and elite athletes across the globe. What makes Lance a uniquely Oklahoma story is how he's using that world-class expertise right here at home to help build a healthier, more resilient state. At HPNRI, he's leading groundbreaking work that ranges from: Physical literacy for Oklahoma children — helping kids move better, feel better, and build lifelong healthy habits. Movement and aging research — studying how older adults can maintain strength, mobility, and independence. Human performance innovation — taking principles once reserved for elite athletes and applying them in schools, clinics, workplaces, and communities across Oklahoma.  https://go.okstate.edu/hpnri/lance-walker Huge thank you to our sponsors. The Oklahoma Hall of Fame at the Gaylord-Pickens Museum telling Oklahoma's story through its people since 1927. For more information go to www.oklahomahof.com and for daily updates go to www.instagram.com/oklahomahof The Chickasaw Nation is economically strong, culturally vibrant and full of energetic people dedicated to the preservation of family, community and heritage. www.chickasaw.net Dog House OKC - When it comes to furry four-legged care, our 24/7 supervised cage free play and overnight boarding services make The Dog House OKC in Oklahoma City the best place to be, at least, when they're not in their own backyard. With over 6,000 square feet of combined indoor/outdoor play areas our dog daycare enriches spirit, increases social skills, builds confidence, and offers hours of exercise and stimulation for your dog http://www.thedoghouseokc.com  #ThisisOklahoma 

In this episode, Dr. Jun Ding joins us to explore how artificial intelligence and machine learning are reshaping biomedical research at the cellular level. Dr. Ding is an Assistant Professor in the Division of Respiratory Medicine at the Research Institute of the McGill University Health Centre and leads the Ding Lab at McGill University's Meakins-Christie Laboratories. Dr. Ding's research focuses on decoding cell dynamics across complex diseases by leveraging advanced single-cell technologies and computational biology. By developing machine-learning models such as probabilistic graphical models, Dr. Ding and his team aim to bridge massive omics datasets with actionable biological insight – paving the way for next-generation diagnostics and therapeutics… Hit play to discover: Why understanding cell dynamics is critical to tackling complex diseases like cancer. How single-cell and spatial omics technologies are revealing previously hidden biological heterogeneity. The role of machine learning in modeling disease progression and identifying new drug targets. To learn more about Dr. Ding and his work, visit The Ding Lab website!

Here's a preview of a new show from our friends at Pushkin Industries and the Atira Health and Research Institute. On Decoding Women's Health, Dr. Elizabeth Poynor makes the science of women's health accessible—from hormones to metabolism to longevity—so you can thrive at any stage of life. A world-renowned gynecologic oncologist and advanced pelvic surgeon, Dr. Poynor speaks with leading physicians, researchers, and educators to share the latest science on women's wellness, disease prevention, and what it really means to age on your own terms. Dr. Poynor recently sat down with preventive neurologist Dr. Richard Isaacson, who shares how to know if you're at risk for Alzheimer's, how shifting hormones can make women especially vulnerable, and what steps to take for better long-term brain health. For more episodes on how to improve your health during midlife, find Decoding Women's Health with Dr. Elizabeth Poynor wherever you get podcasts. Learn more about your ad choices. Visit megaphone.fm/adchoices