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2 episodes with disease research
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2 episodes with disease research
Sometimes, you need to go the extra mile to make a point—like buying every medicine at CVS to show regulators that medicine can, and often does, have flavor. Sensible regulations should be rooted in logic, not outdated prohibition fears or baseless stigmas. If cannabis is legalized, it should be treated like any other industry, not one plagued by fear of being a shadowy boogeyman.This week, we sit down with Wendy Bronfein to dive into:Key Differences Between Maryland and Missouri's Cannabis MarketsEmerging Marketing Trends and Customer-Focused StrategiesInnovative Crohn's Disease Research and Product Development...and so much more. Chapters:Introduction and Background (00:00:00) - Brian and Kellen introduce their guest Wendy Bronfein, co-founder of Cura Wellness. Wendy shares her background in the television industry and how she transitioned into the cannabis space.Early Days of Maryland Cannabis (00:01:15) - Wendy discusses how her family became involved in the Maryland medical cannabis market, including their trip to Colorado and the process of applying for a license in 2015.Launching Curio Wellness (00:02:47) - The company won a license, built their facility, and became operational in 2017, shipping to licensed dispensaries in December of that year.Transition to Adult Use (00:03:07) - Maryland transitioned from medical to adult-use cannabis in July, with Wendy explaining the regulatory changes and market dynamics.Product Innovation and Research (00:33:59) - Curio Wellness discusses their approach to product development, including specialized products for sleep, mood, and potential medical treatments like a Crohn's disease tablet.Marketing Challenges and Regulations (00:25:16) - Wendy explains the marketing restrictions in Maryland compared to Missouri, highlighting the challenges of advertising in the cannabis industry.Personal Insights and Closing (00:42:33) - The interview concludes with personal questions about Wendy's dream smoking session, her views on branding, and her favorite ice cream. Guest Linkshttps://curiowellness.com/https://x.com/curiowellnesshttps://www.instagram.com/curiowellnessbrand/https://www.linkedin.com/company/curio-wellness/https://www.youtube.com/channel/UCeT6Sut8Wsi4Xr_o9uq0edQhttps://www.linkedin.com/in/wbronfein/Our LinksBryan Fields on Twitter Kellan Finney on Twitter The Dime on Twitter At Eighth Revolution (8th Rev), we provide services from capital to cannabinoid and everything in between in the cannabinoid industry.8th Revolution Cannabinoid Playbook is an Industry-leading report covering the entire cannabis supply chain The Dime is a top 5% most shared global podcast The Dime has a New Website. Shhhh its not finished. The Dime is a top 50 Cannabis Podcast Sign up for our playbook here:
Sometimes, you need to go the extra mile to make a point—like buying every medicine at CVS to show regulators that medicine can, and often does, have flavor. Sensible regulations should be rooted in logic, not outdated prohibition fears or baseless stigmas. If cannabis is legalized, it should be treated like any other industry, not one plagued by fear of being a shadowy boogeyman.This week, we sit down with Wendy Bronfein to dive into:Key Differences Between Maryland and Missouri's Cannabis MarketsEmerging Marketing Trends and Customer-Focused StrategiesInnovative Crohn's Disease Research and Product Development...and so much more. Chapters:Introduction and Background (00:00:00) - Brian and Kellen introduce their guest Wendy Bronfein, co-founder of Cura Wellness. Wendy shares her background in the television industry and how she transitioned into the cannabis space.Early Days of Maryland Cannabis (00:01:15) - Wendy discusses how her family became involved in the Maryland medical cannabis market, including their trip to Colorado and the process of applying for a license in 2015.Launching Curio Wellness (00:02:47) - The company won a license, built their facility, and became operational in 2017, shipping to licensed dispensaries in December of that year.Transition to Adult Use (00:03:07) - Maryland transitioned from medical to adult-use cannabis in July, with Wendy explaining the regulatory changes and market dynamics.Product Innovation and Research (00:33:59) - Curio Wellness discusses their approach to product development, including specialized products for sleep, mood, and potential medical treatments like a Crohn's disease tablet.Marketing Challenges and Regulations (00:25:16) - Wendy explains the marketing restrictions in Maryland compared to Missouri, highlighting the challenges of advertising in the cannabis industry.Personal Insights and Closing (00:42:33) - The interview concludes with personal questions about Wendy's dream smoking session, her views on branding, and her favorite ice cream. Guest Linkshttps://curiowellness.com/https://x.com/curiowellnesshttps://www.instagram.com/curiowellnessbrand/https://www.linkedin.com/company/curio-wellness/https://www.youtube.com/channel/UCeT6Sut8Wsi4Xr_o9uq0edQhttps://www.linkedin.com/in/wbronfein/Our LinksBryan Fields on Twitter Kellan Finney on Twitter The Dime on Twitter At Eighth Revolution (8th Rev), we provide services from capital to cannabinoid and everything in between in the cannabinoid industry.8th Revolution Cannabinoid Playbook is an Industry-leading report covering the entire cannabis supply chain The Dime is a top 5% most shared global podcast The Dime has a New Website. Shhhh its not finished. The Dime is a top 50 Cannabis Podcast Sign up for our playbook here:
Last month, the NIH announced that it had found evidence of research misconduct by Eliezer Masliah, M.D., the head of the neuroscience division at the National Institute on Aging. The NIH announcement coincided with the Sept. 26 publication of an investigation by Science, finding that 132 papers published by Masliah appear to contain manipulated images. In this week's episode of “The Top Line,” Fierce Biotech's Darren Incorvaia dives into this issue with Matthew Schrag, M.D., Ph.D., a neuroscientist who contributed to the dossier outlining Masliah's misconduct. To learn more about the topics in this episode: NIH neuroscience leader committed research misconduct, agency investigation findsSee omnystudio.com/listener for privacy information.
In this month's episode, Roberto and Martha chat with Dr. Paula Desplats, an associate professor at UCSD who is currently researching the role of circadian alterations that trigger neuronal death in Alzheimer's disease. Paula discusses the cutting-edge research happening in San Diego and ways for caregivers and their loved ones to get involved in research. Keywords: alzheimer's disease research, brain research, Parkinson's research, treatment, cure
Jonathan Soong, General Manager of Amicus Therapeutics, gives insights into being at the forefront of rare disease innovations, patient support programs, and the importance of real world evidence for rare diseases. Get full access to NPC Healthbiz Weekly at healthbiz.substack.com/subscribe
Kidney Week 2024 on the go. Gentzon Hall, MD, PhD, FASN, Matthias Kretzler, MD, and Heather Reich, MD, PhD, discuss progress in glomerular disease research, emerging trends, and clinical challenges.
Kidney Week 2024 on the go. Gentzon Hall, MD, PhD, FASN, Matthias Kretzler, MD, and Heather Reich, MD, PhD, discuss progress in glomerular disease research, emerging trends, and clinical challenges.
Dr. Brad White of Kansas State University and Director of the Beef Cattle Insitute talks about his team's research into Bovine respiratory disease, or Shipping Fever. Bovine respiratory disease costs ranchers in the United States about $900 million annually due to animal death, reduced feed efficiency and treatment costs. The research represents the most comprehensive assessment of risk factors and pathological characteristics of late day pulmonary disease ever reported, generating valuable results that will help ranchers and veterinarians improve animal welfare, mitigate the negative impacts of this disease while promoting antimicrobial stewardship.
Broadcast from KSQD, Santa Cruz on 5-30-2024 and 9-05-2024: Cognitive errors in medicine dismissing unusual presentations as psychological A case of Pediatric Autoimmune Neuropsychiatric disorders Associated with Streptococcal Infections (PANDAS) Anti-NMDA receptor encephalitis causing psychiatric symptoms Failures of genetic research to identify causes Need for integrating neurology and psychiatry; Importance of testing for antibodies and using MRI scans Detailed explanation of immune tolerance, peripheral tolerance, and the phenomenon of molecular mimicry in diseases like multiple sclerosis and celiac disease Importance of addressing root causes rather than just symptoms Historical context and current advancements in treating autoimmune diseases like type 1 diabetes, lupus, and multiple sclerosis using reprogrammed immune cells and iron oxide nanoparticles Explanation of how the liver filters blood and helps establish immune tolerance by processing cellular debris and antigens Advances in engineering regulatory T cells to target specific disease sites and calm inflammatory responses Exploration of new diagnostic tools and the potential of AI in understanding complex psychiatric conditions Detection of colds and other diseases by analysis of voice frequency patterns
In 2010, our guest, Rob Long, was on the cusp of an NFL career after being a star punter at Syracuse University. But that bright future was sidelined when Rob was diagnosed with a rare and aggressive brain tumor just five days after his final college game. Fortunately, emergency surgery and treatment gave him a second chance. As you'll learn in this fascinating episode of Raise the Line, a new purpose took the place of his NFL dreams and today he's the executive director of Uplifting Athletes, a nonprofit using sports to raise awareness and resources for rare diseases. One signature program developed under his leadership is the Young Investigator Draft held annually since 2018 at the home stadium of the Philadelphia Eagles. “Our program is modeled after the NFL draft, but instead of drafting the top athletes in the country, we draft and fund the next generation of rare disease researchers,” Long tells host Lindsey Smith. So far, Uplifting Athletes has provided fifty researchers with over one million dollars in grants through this approach. Tune in to learn about other innovative work that has connected hundreds of rare disease patients with professional athletes and provided opportunities for researchers to attend patient & family conferences as our Year of the Zebra focus on rare disorders continues. Mentioned in this episode: Uplifting Athletes
Welcome! Today, we're exploring the key milestones in Lyme disease research and treatment.I had a 57-year-old patient who remained chronically ill after being diagnosed and treated for Lyme disease. He didn't realize that a persistent tick-borne infection could explain his chronic illness. He was treated with a combination of azithromycin and atovaquone for the persistent infection, and today, he is doing well.He was surprised that, despite the milestones in Lyme disease research, he wasn't aware that a persistent infection could lead to his chronic illness. So, let's take a closer look at these milestones.1. 1977: Discovery of Lyme DiseaseOur story begins in 1977 in Lyme, Connecticut. A cluster of children and adults were diagnosed with what was initially thought to be juvenile rheumatoid arthritis. This event marked the identification of Lyme disease as a distinct illness and the start of modern Lyme disease awareness."2. 1982: Discovery of the Bacterium Responsible for Lyme DiseaseIn 1982, Dr. Willy Burgdorfer identified Borrelia burgdorferi, the bacterium responsible for Lyme disease. This discovery was a major milestone, enabling more precise identification and treatment of the disease. 3. 1990: Recognition of Chronic Lyme DiseaseBy 1990, chronic Lyme disease, with its long-term and persistent symptoms, was officially recognized. This led to more comprehensive treatment protocols and increased awareness of the disease's chronic nature.4. 1995: Discovery of Babesia microtiIn 1995, Babesia microti was identified as a co-infection transmitted by the same ticks that carry Lyme disease. This highlighted the complexity of tick-borne illnesses and the need for integrated treatment approaches. 5. 2000: Publication of IDSA and ILADS GuidelinesThe year 2000 saw the publication of treatment guidelines by both the Infectious Disease Society of America (IDSA) and the International Lyme and Associated Diseases Society (ILADS). These guidelines showcased different approaches to treating Lyme disease, marking another significant milestone. 6. Ongoing Research and Future Milestones Research is ongoing, and we look forward to future milestones that could lead to breakthroughs in diagnosis and treatment. Studies on biofilms, persisters, and tick-borne co-infections may enable doctors to develop treatment plans that significantly improve patient outcomes.ConclusionUnderstanding these milestones helps us appreciate the progress made in the fight against Lyme disease. With continued research and dedication, we move closer to effective management and potential cures. Thank you for watching, and stay tuned for more insights on Lyme disease."
Interview with Sharon Brangman, MD, Upstate geriatrics chief
What to expect at Blackhat/DEFCON, Identifying Explosives, OpenAI's new models, Llama 4 Timeline, and more… ➡ Check out Vanta and get $1000 off:vanta.com/unsupervised Subscribe to the newsletter at: https://danielmiessler.com/subscribe Join the UL community at:https://danielmiessler.com/upgrade Follow on X:https://twitter.com/danielmiessler Follow on LinkedIn:https://www.linkedin.com/in/danielmiessler See you in the next one!Discussed in this episode:Intro (00:00:00)OSINT and the Pizza Index (00:01:08)Agent Framework Development (00:02:12)State of Cybersecurity (00:04:08)Critical Security Vulnerabilities (00:05:27)Ransomware Trends (00:06:25)Data Breach Costs (00:07:29)AI Developments (00:08:40)California AI Regulation (00:09:42)OpenAI's GPT-4 Launch (00:11:01)Tech Company Updates (00:12:03)Shifts in Workforce Dynamics (00:13:07)Prisoner Swap News (00:17:06)Shark AI Model (00:18:03)Dementia Prevention Insights (00:19:03)Genetics of Self-Control (00:20:12)Name and Appearance Study (00:20:12)Alzheimer's Disease Research (00:20:12)Dungeons and Dragons Rulebooks (00:20:12)Novelists Writing Bug Reports (00:21:22)Recent UBI Study Analysis (00:21:22)Free-Range Kids Initiative (00:21:22)Discovery Farm Bot (00:22:13)Super Memory AI (00:22:13)Avi Shipman's AI Pendant (00:22:13)Installing Fabric (00:22:13)Fleet Open Source Tool (00:22:13)SOC2 Policy Templates (00:22:13)Clutch Security Platform (00:22:13)Black Hat Reminder (00:23:48)Aphorism of the Week (00:23:48)Become a Member: https://danielmiessler.com/upgradeSee omnystudio.com/listener for privacy information.
Join us as we welcome back Dr. Veera Rajagopal, a discovery scientist at Regeneron with an interest in human genetics and drug target discovery in neuroscience and psychiatry. If you're a regular listener of The Genetics Podcast, you are likely familiar with Dr. Veera's annual round-up episodes. This year, we are excited to announce quarterly episodes with Dr. Veera, where he and Patrick walk you through the latest developments in genetics, drug discovery, and precision medicine throughout the year. This quarter's episode will dive into the discovery of a recurrent de novo mutation in a noncoding region linked to neurodevelopmental disorders, the role of RAB32 in Parkinson's disease (PD), insights into monogenic conditions like systemic lupus erythematosus, and new perspectives on Alzheimer's genetics. Tune in now, and don't forget to check out Veera's substack, GWAS Stories, and his Twitter, @doctorveera.
This week brought more hot temperatures to the US, and wildfires to Canada, but planters continued to roll. Delaney caught up with Dr. Megan Niederwerder, Executive Director of SHIC, to talk about their work at the Swine Health Information Center with a specific focus on foreign animal disease research. This week's headlines include weather, planting progress, the latest Avian Influenza updates, cash rents, and a daily agronomy update with REDSTAR! And be sure to stick around for the very end of the show, when we cover a weekly recap of the markets. Don't forget to hit subscribe! Follow us on social media!
Join Fred Bodimer for the latest insights into health news from around the globe. Discover updates on the potential timeline for the next round of COVID vaccines, with manufacturers aiming for availability as early as August pending regulatory approvals. Explore advancements in sleep apnea treatment, including a promising one-pill-a-night drug currently in clinical trials, as well as the potential role of weight loss drugs in reducing obstructive sleep apnea.
KSQD 05-30-2024: Topics discussed include: Cognitive errors in medicine dismissing unusual presentations as psychological A case of Pediatric Autoimmune Neuropsychiatric disorders Associated with Streptococcal Infections (PANDAS) Anti-NMDA receptor encephalitis causing psychiatric symptoms Failures of genetic research to identify causes Need for integrating neurology and psychiatry; Importance of testing for antibodies and using MRI scans Detailed explanation of immune tolerance, peripheral tolerance, and the phenomenon of molecular mimicry in diseases like multiple sclerosis and celiac disease Importance of addressing root causes rather than just symptoms Historical context and current advancements in treating autoimmune diseases like type 1 diabetes, lupus, and multiple sclerosis using reprogrammed immune cells and iron oxide nanoparticles Explanation of how the liver filters blood and helps establish immune tolerance by processing cellular debris and antigens Advances in engineering regulatory T cells to target specific disease sites and calm inflammatory responses Exploration of new diagnostic tools and the potential of AI in understanding complex psychiatric conditions
Send us a Text Message.A Gluten Free Podcast Episode 127 My guest on today's episode is Associate Professor, gastroenterologist & coeliac disease researcher, Jason Tye-Din. We'll talk about his own allergy journey & personal connection to coeliac disease, developing simple diagnoses, gluten exposure testing, possible preventions for this condition & the mental health research around coeliac disease. What we'll cover: * Jason's personal journey of living with a peanut allergy * Jason's wife's coeliac disease diagnosis * Developing simple & effective diagnoses: Interleukin 2 (possibility of avoiding gluten challenge & gastroscopy in future) * Stool & urine gluten exposure testing * The current research into brain fog & other various mental health associations with coeliac disease * Disorder of the gut/brain axis (DGBI), gut hypnotherapy & the gut microbiome * Australia first ENDIA study (Environmental Determinants of Islet Autoimmunity) in relation to Type 1 Diabetes & coeliac disease research * How to get involved & find out more about the research & trials Links WEHI website Current coeliac disease clinical trials Buy tickets to A Gluten Free Evening
Dr. Pierre Vanderhaeghen is a Professor and Principal Investigator at VIB-KU Leuven Center for Brain & Disease Research. His lab studies the mechanisms of cortical development and brain evolution. He talks about species-specific neuronal development, human neuron excitability, and playing in a rock cover band!
Parkinson's disease is the fast-growing neurological condition in the world. In Canada, more than 100,000 people are currently living with Parkinson's and 12,000 new cases are diagnosed every year. In this episode of Your Complex Brain, we discuss the latest science surrounding the benefits of exercise for Parkinson's, including whether exercise can alleviate some of the symptoms of Parkinson's or slow the progression of the disease.Featuring: Dr. Lorraine Kalia is a Neurologist & Senior Scientist at UHN's Krembil Brain Institute and the Wolfond-Krembil Chair in Parkinson's Disease Research at UHN. She is also an Associate Professor at the University of Toronto.Steve Iseman is currently living with Parkinson's. He is co-founder of the ‘Rigid Riders,' a Toronto-based cycling group for people living with Parkinson's, and an avid cyclist & skier.Additional resources: UHN Movement Disorders Clinic websiteKalia Labs websiteDr. Lorraine Kalia on why she studies Parkinson's (video) The Rigid Riders Story (video)Spinning Wheels Cycling Tour The Your Complex Brain production team is Heather Sherman, Jessica Schmidt, Dr. Amy Ma, Kim Perry, Sara Yuan, Meagan Anderi, Liz Chapman, and Lorna Gilfedder.The Krembil Brain Institute, part of University Health Network, in Toronto, is home to one of the world's largest and most comprehensive teams of physicians and scientists uniquely working hand-in-hand to prevent and confront problems of the brain and spine, such as Parkinson's, Alzheimer's, epilepsy, stroke, spinal cord injury, chronic pain, brain cancer or concussion, in their lifetime. Through state-of-the-art patient care and advanced research, we are working relentlessly toward finding new treatments and cures.Do you want to know more about the Krembil Brain Institute at UHN? Visit us at: uhn.ca/krembilTo get in touch, email us at krembil@uhn.ca or message us on social media:Instagram - @krembilresearchTwitter - @KBI_UHNFacebook - https://www.facebook.com/KrembilBrainInstituteThanks for listening!
“As a nurse, I'm all about lifestyle strategies and preventing Alzheimer's from even happening to us” —Melissa Batchelor, PhD, RN, FNP, FGSA, FAAN Alzheimer's disease poses a significant threat to individuals and societies worldwide due to its devastating impact on cognitive function and quality of life. Although a cure has not been found, ongoing research gives hope for better treatments to ease symptoms, slow down the disease, and make life better for people with Alzheimer's. THE STATE OF ALZHEIMER'S DISEASE RESEARCH Alzheimer's disease, a top 10 leading cause of death, remains a problem in medical science. Despite decades of research and billions of dollars invested, no effective prevention, treatment, or cure exists. The failure rate of clinical drug trials is staggering, with over 146 drugs failing to deliver promising results. CHALLENGES IN DRUG DEVELOPMENT The complexity of Alzheimer's disease poses significant challenges in drug development. Many experimental drugs fail because they either don't work or cause serious side effects. In this episode, I explain several reasons for this including misdiagnosed study participants, the impact of research focus, and more. FUTURE DIRECTIONS OF CLINICAL RESEARCH The future of Alzheimer's disease research lies in a multifaceted approach, targeting various aspects of the disease's pathology. New studies show that inflammation plays a big role in damage to the brain in Alzheimer's disease, which opens up possibilities for new treatments. While clinical trials continue to face challenges, there's hope that personalized treatments and lifestyle changes can lower the risk of Alzheimer's. HOW TO KEEP A HEALTHY BRAIN To keep your brain healthy, proactive measures play an important role. Lifestyle strategies like managing blood pressure, maintaining a healthy weight, and engaging in regular physical activity, can significantly reduce the risk of cognitive decline. While we're waiting for breakthroughs in drug development, these strategies give us all ways we can take control of our brain health. RESOURCES Two great resources can help you keep your brain healthy. The AARP Staying Sharp program provides access to cognitive assessments, daily activities, and educational resources, promoting brain-healthy habits. Additionally, the Brain Health Resource Center offers comprehensive information on Alzheimer's disease and related conditions, along with free hearing tests for AARP members. ------------------------------------------------------------------------ About MelissaBPhD Melissa Batchelor, PhD, RN, FNP, FGSA, FAAN. I am a nurse, nurse practitioner with over 25 years of experience caring for older adults and their families. Below are 4 ways to connect with and support the podcast: BECOME AN AGEWISEU INSIDER: Visit my website at https://melissabphd.com/join/ and sign up for free! Updated weekly, AgeWiseU is a digital hub of over 175 hours of content, resources, helpful links and courses designed for caregivers of people living with dementia; adult children caring for aging parents; and anyone wanting to learn more about brain health and healthy aging! BECOME A YOUTUBE MEMBER: Get early access to my podcast episodes and join me for a members-only monthly live webinar! SUBSCRIBE, LIKE, SHARE, AND LEAVE A REVIEW: SUBSCRIBE to this YouTube Channel; LIKE the podcast by giving this episode a thumbs up; SHARE this episode with others; and LEAVE A REVIEW. These things only take a minute of your time, but they really do help increase my rating and ranking; but more importantly, these actions help other people find the podcast. JOIN THE FACEBOOK COMMUNITY: If you are on Facebook, feel free to join my private community here: https://www.facebook.com/groups/thisisgettingold
In this segment, we feature insights from Bill Repicci's presentation at the Heart to Heart virtual event, which took place from March 31 to April 2, 2023.Bill Repicci, serving as the President & CEO of the Lymphatic Education & Research Network (LE&RN), discusses the psychological effects of lymphatic diseases and emphasizes the importance of self-advocacy.
The Parkinson’s Research Podcast: New Discoveries in Neuroscience
Increasing evidence supports the presence of sex and gender differences in neurodegenerative conditions, including Alzheimer's disease and Parkinson's disease. There is a critical need to more closely examine sex and gender differences in all stages of research, therapeutic development, and clinical treatment to enable better outcomes through precision medicine approaches. This episode focuses on the relevance of sex and gender factors in Parkinson's disease and efforts to transform scientific research, policy, and healthcare to identify and address needs based on sex and gender. Our guest Dr. Antonella Santuccione Chadha discusses her work with the Women's Brain Project, their recent roundtable on enhancing care in Parkinson's disease, and the organization's goals for the future. Antonella is a medical doctor with experience spanning positions in clinical care, academic research, the Swiss Agency for Therapeutic Products (regulatory), and industry leadership and consultation for large pharmaceutical companies and smaller start-up companies. She is currently Co-Founder and Pro Bono Chief Executive Officer of the Women's Brain Project, an international non-profit organization studying sex and gender determinants to brain and mental health.This podcast is geared toward researchers and clinicians. If you live with Parkinson's or have a friend or family member with PD, listen to The Michael J. Fox Foundation Parkinson's Podcast. Hear from scientists, doctors and people with Parkinson's on different aspects of life with the disease as well as research toward treatment breakthroughs at https://www.michaeljfox.org/podcasts.
This is episode 20 of the Love, Hope, Lyme podcast. Fred Diamond's popular book, "Love, Hope, Lyme: What Family Members, Partners, and Friends Who Love a Chronic Lyme Survivor Need to Know" offers those who love someone with persistent or chronic Lyme ideas and tips to support this beloved person. It also helps Lyme survivors know how to ask for support. On today's podcast, Fred interviews Bonnie Crater, Co-Founder of the Center for Lyme Action. When Fred conducted the research for his book “Love, Hope, Lyme: What Family Members, Partners, and Friends Who Love a Chronic Lyme Survivor Need to Know,” he realized he had no idea of the political issues surrounding Lyme and other tick-borne diseases, and the lack of Federal Government funding the diseases received, compared to other diseases. On this week's Love, Hope, Lyme podcast, Bonnie discusses the history of Lyme disease funding advocacy and the strides that have been made in recent years. She also discusses the upcoming Virtual Fly-Ins, where Lyme disease advocates will have an opportunity to discuss the challenges behind the diseases with their elected officials. If someone you love has been afflicted with Lyme disease, listen to this podcast now. The e-version of Fred's book is always free for Lyme survivors. Just reach out to Fred on Facebook or LinkedIn. The print copy can be ordered at https://www.amazon.com/Love-Hope-Lyme-Partners-Survivor-ebook/dp/B0B9Q8LX7G/.
What is the rare Gaucher disease and how does it impact patients, families, and life sciences? Is enough emphasis being placed on research and discovery for rare diseases? And what are the patient-centered approaches that best serve those battling rare diseases? We will get those answers and more in this episode with Tanya Collin-Histed, CEO of the International Gaucher Alliance. Tanya has been a longtime driving force in supporting patients with rare diseases and advocating for world-class healthcare. Her work has been nothing short of groundbreaking and she's become the go-to person for patients, medical practitioners, industry, and governing bodies. As a mother of a child with Gaucher disease, she brings a unique, first-hand, and compassionate approach.
ONCE UPON A GENE - EPISODE 214 A Courageous Gift - The Power of Brain and Tissue Donation in Rare Disease Research with Anne Rugari Anne Rugari is an advocating powerhouse, an author of two children's books, a mom, and two of her children have passed away from Krabbe disease. She joins us to share her personal story and also share her knowledge about tissue and organ donation. EPISODE HIGHLIGHTS Can you share how you became part of the rare disease world? In 1986, my second child Nick received a diagnosis of Krabbe disease, or globoid cell leukodystrophy, a terminal disease that took him just after his first birthday. I also had a three year old son who was unaffected and we decided we probably wouldn't have another child with a rare disease if we wanted more children. In 1999, my daughter Gina was born and tested for Krabbe disease, confident the odds were with us. Unfortunately, she tested positive. As a result of an umbilical cord blood transplant she had at three weeks old, she did remarkably well and lived to fifteen years old. What were your considerations when deciding to donate Gina's brain for research? It's an emotional, practical and religious decision. There are so many factors that play into the decision. For me personally, I wanted to make sure I was making a sound decision morally and spiritually. I felt we weren't going to learn more about the disease unless there were human tissues and samples to study. It was a decision I felt strongly about to help others. There's a source of comfort knowing that the tissues donated are being used to move research forward. Why is it important to consider and arrange tissue donation in advance? It's emotional and you don't want to be making those decisions at a time when you've lost them. There's also some coordination that needs to be planned, ensuring there's a pathologist available at the hospital for the retrieval. Planning in advance allows you time to coordinate the details, like if passing takes place at home instead of the hospital, and notifying the funeral home so they can coordinate with the pathologist. Getting the logistics organized in advance makes the transition when someone passes away easier. Discuss plans in advance with your care team so they can help with arrangements and support you. LINKS AND RESOURCES MENTIONED ONCE UPON A GENE - EPISODE 213 - Finding Strength In Every Step https://effieparks.com/podcast/episode-213-finding-strength-in-every-step ONCE UPON A GENE - EPISODE 198 - Advocating with Heart - Striking the Balance Between Medical Insights and Personal Narratives - A Tribute to Valerie Marie with RING14 Co-Founder Yssa Dean DeWoody https://effieparks.com/podcast/episode-198-advocating-with-heart Courageous Parents Network https://courageousparentsnetwork.org/ Anne Rugari Website https://www.annerugari.com/ Just Like Me!: A Book About A Girl with a Rare Disease https://www.amazon.com/Just-Like-Me-about-Disease/dp/0982218710 Just Like Me Too! https://www.amazon.com/Just-Like-Too-Anne-Rugari/dp/1970063378 CONNECT WITH EFFIE PARKS Website https://effieparks.com/ Twitter https://twitter.com/OnceUponAGene Instagram https://www.instagram.com/onceuponagene.podcast/?hl=en Built Ford Tough Facebook Group https://www.facebook.com/groups/1877643259173346/
Lauren Drouin is the director of analytical development and the Genomic Medicine Unit at Alexion AstraZeneca Rare Disease. As a dynamic scientist with unique expertise in current research and industry trends for gene therapies, Drouin is passionate about driving progress within the rare disease field and advancing products from preclinical development into the clinic and beyond. In this Science Philosophy in a Flash podcast episode brought to you by Bio-Rad, The Scientist's Creative Services Team spoke with Drouin to learn more about her interest in adeno-associated virus (AAV) biology, and what motivated her journey from academia to patient-focused analytical development research. Science Philosophy in a Flash is a series of mini podcasts produced by The Scientist's Creative Services Team. With a focus on the people behind the science, this podcast highlights researchers' unique outlook on what motivates their pursuit of science and what it means to be a scientist. This episode is brought to you by Bio-Rad.
Angela is joined by Dr. Dale Bredesen, who discusses the prevalence of Alzheimer's disease and the difference between Alzheimer's and other forms of dementia. He emphasises the importance of early detection and treatment, as Alzheimer's is a progressive disease that can be present for many years before symptoms appear. Dr. Bredesen explains the four phases of Alzheimer's and the potential for prevention and reversal of cognitive decline through lifestyle interventions. KEY TAKEAWAYS Alzheimer's disease is a common and devastating form of dementia that affects millions of people worldwide. Alzheimer's is characterized by a progressive decline in cognitive function, including memory loss, difficulty with language and communication, and impaired daily functioning. Early detection and intervention are crucial in managing Alzheimer's disease. The earlier the treatment is initiated, the better the chances of preventing or reversing cognitive decline. Lifestyle factors such as diet, exercise, sleep, stress management, brain training, detoxification, and targeted supplements play a significant role in preventing and managing Alzheimer's disease. Hormone therapy, specifically bioidentical hormone replacement, may be beneficial for women experiencing menopause-related cognitive decline BEST MOMENTS "Your generation is the first generation that does not have to fear Alzheimer's." "We can pretty much prevent it or do early reversals in just about everyone." "We do see people even in late stages where we get some improvement, but they don't tend to come all the way back to normal." "Sleep is one of the ways that you stay sharp, that you improve your processing speed." VALUABLE RESOURCES Get a free snapshot of your health and personalised report at www.yourtotalhealthcheck.com Join The High Performance Health CommunityFree Fasting Guide - www.angelafosterperformance.com/fastingPodcast Shownotes - www.angelafosterperformance.com/podcasts Episode 212 - https://omny.fm/shows/high-performance-health/the-science-of-manifestation-how-to-use-neuroplast ABOUT THE GUEST Dale Bredesen, MD, received his undergraduate degree from Caltech and his medical degree from Duke University. He served as resident and chief resident in neurology at the University of California, San Francisco (UCSF) and as postdoctoral fellow in the laboratory of Nobel Laureate Professor Stanley Prusiner. He was a faculty member at UCLA from 1989 to 1994 and was then recruited by the Burnham Institute to direct the Program on Aging. In 1998, he became the founding president and CEO of the Buck Institute for Research on Aging and adjunct professor at UCSF. In 2013, he returned to the University of California, Los Angeles (UCLA) as director of the Easton Center for Alzheimer's Disease Research and he is currently a professor. The Bredesen Laboratory studies basic mechanisms underlying the neurodegenerative process and the translation of this knowledge into effective therapeutics for Alzheimer's disease and other neurodegenerative conditions, which has led to the publication of over 200 research papers. He is the principal investigator for the Alzheimer's Disease Research Center at UCLA. He established the ADDN (Alzheimer's Drug Development Network) with Dr. Varghese John in 2008, leading to the identification of new classes of therapeutics for Alzheimer's disease. His group has developed a new approach to the treatment of Alzheimer's disease, the MEND protocol, and this approach has led to the first description of a reversal of symptoms in patients with mild cognitive impairment (MCI) and early Alzheimer's disease. Dr. Bredesen is the author oftwo New York Times best sellers: The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Declineand The End of Alzheimer's Program. ABOUT THE HOST Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women's Biohacking Conference, Livestrong & Natural Health Magazine. Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out. Angela's BioSyncing®️ Blueprint is currently closed. Click here to get on the waitlist. The High Performance Health Podcast is a top rated global podcast. Each week, Angela brings you a new insight, biohack or high performance habit to help you unlock optimal health, longevity and higher performance. Hit the follow button to make sure you get notified each time Angela releases a new episode. CONTACT DETAILS Instagram Facebook LinkedIn
Subscribe to Receive Venkat's Weekly Newsletter AP Physics was the first course Isabella took in High School that challenged her. It really pushed her to think outside the box. Then a senior project opened her eyes to diseases that affected not only the elderly but young people as well. That got her thinking about college and Pre Med. Isabella joins us on our podcast to share her undergraduate experience at Rice, Transition to college, Autoimmune Disease UG Research, Impact of Research, and Advice for High Schoolers. In particular, we discuss the following with her: Overall Experience at Rice UG Research & Its Impact on UG study Majoring in Biochem & Cell Biology Advice to High Schoolers Topics discussed in this episode: Introduction to Isabella Osuna of Rice U [] Hi Fives - Podcast Highlights [] Overall Rice Experience [] Why Rice? [] High School Interests [] Transition to College [] Peers [] Professors [] Starting UG Research [] Autoimmune Disease Research [] Noteworthy Outcomes [] Impact of UGR [] Skills Gained Through Research [] Campus Activities [] Summers [] Majoring in Biochemistry & Cell Biology [] Advice for High Schoolers [] Memory [] Our Guests: Isabella Osuna graduated with a Bachelor's Degree in Biochemistry & Cell Biology from Rice University. Memorable Quote: “... If I had to give one word, probably determination, I don't know if it's a skill you necessarily pick up or learn. But it was. I mean, research is hard, science is hard and difficult. And at first my research wasn't working, I was finding my results were the opposite of what we want and what we expected. But I didn't stop.” Isabella Osuna. Episode Transcript: Please visit Episode's Transcript. Similar Episodes: College Experiences Calls-to-action: Follow us on Instagram To Ask the Guest a question, or to comment on this episode, email podcast@almamatters.io. Subscribe or Follow our podcasts at any of these locations: Apple Podcasts, Google Podcasts, Spotify.
We don't have to fear Alzheimer's and cognitive decline like generations before us. Thanks to dedicated researchers and doctors like today's guest, we know why Alzheimer's happens – and how to prevent it.Dr. Dale Bredesen received his undergraduate degree from Caltech and his medical degree from Duke University. In 2013, he returned to UCLA as the director of the Easton Center for Alzheimer's Disease Research. The Bredesen Laboratory studies the basic mechanisms underlying the neurodegenerative process and the translation of the knowledge into effective therapies for Alzheimer's disease. He has published over 230 papers and has written two New York Times bestselling books, The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline, and The End Of Alzheimer's Program. In today's episode, he fills us in on everything he knows about how to protect your brain from this disease, what Alzheimer's is, how we can reverse and prevent it, and blood tests that can indicate our odds of getting it. Dr. Bredesen is a beacon of hope for so many of us and for families that have been affected by this disease. Knowing that we have the tests to catch early signs of cognitive decline and can harness the power of the Bredesen Protocol to fight inflammation through diet and lifestyle changes in our earlier years means that we can end Alzheimer's.We also cover…(00:01:53) Preventing Alzheimer's(00:06:56) The 4 Stages of Alzheimer's(00:16:12) Understanding the Root Cause of Alzheimer's(00:22:40) Alzheimer's Testing 101(00:25:52) Addressing the Glucose Energetic Emergency(00:30:48) The Bredesen Protocol: Diet Recommendations To Prevent Alzheimer's(00:38:36) What Leads to Brain Inflammation & How To Identify It(00:47:12) Why Alzheimer's Is a Women Centric Disease(00:50:22) Best-in-Class Methods for Reducing Brain InflammationThis episode is brought to you by:BWBK Protein Powder | Get $10 off your order with PODCAST10 at bewellbykelly.com.Cozy Earth | Get 35% off site wide when you use the code BEWELL at CozyEarth.com.MasterClass | This holiday season, give one annual membership and get one free at masterclass.com/bewell. Resources:Click here for full show notesRead: The End of Alzheimer's by Dr. Dale BredesenRead: The End of Alzheimer's Program by Dr. Dale BredesenWebsite:
In a groundbreaking discovery earlier this year, a global consortium found a new variant in the GBA gene that is associated with a higher risk of Parkinson's disease (PD) for people of African ancestry. The finding marks the first African ancestry-specific genetic risk factor for Parkinson's disease. In this podcast, researchers share the human stories behind the discovery, which underscores the importance of international collaboration and the participation of underrepresented communities in research. Themes covered in this discussion: (02:05) – Breaking down the genetic discovery and why it's important for PD research (05:27) – More on the genetic samples that resulted in this discovery (06:53) –Why the GBA1 gene is of interest and its connection to PD (11:13) – How the Global Parkinson's Genetics Program (GP2) maintains privacy and confidentiality of data from study participants (13:15) – How people should think about genetics as a risk factor for PD (14:55) – Capacity building and building community trust (19:57) –Why this discovery takes us closer to finding better treatments and a cure for PD (21:51) – Story behind accidental discovery of GBA1 variant (22:50) – Background on GP2 and excitement on the GBA1 variant discovery (33:17) – Ethnicity and health risk factors and other determinants of health (35:03) – Importance of diversity, equity and inclusion in science and to The Michael J. Fox Foundation's mission (36:52) – Research in PD historically focused on people of Northern European ancestry (38:09) –Why people from underrepresented groups need to lead these studies (39:30) – Importance of including underrepresented populations across the research pipeline (40:18) –Why research participation is important and how you can get involved Like our podcasts? Please consider leaving a rating or review and sharing the series with your network. https://apple.co/3p02Jw0 Whether you have Parkinson's or not, you can help move research forward. Join the study that's changing everything. Find out more at michaeljfox.org/podcast-ppmi
In this episode, Rasa discusses the innovative research being conducted by Dr. Lisa Barnes at Rush University Medical Center and how she is helping close the gap in Alzheimer's disease research disparities faced by people of color. Lisa L. Barnes, PhD is the Alla V. and Solomon Jesmer Professor of Gerontology and Geriatric Medicine and a cognitive neuropsychologist within the Rush Alzheimer's Disease Center at Rush University Medical Center. She is also the Associate Director of the Rush Alzheimer's Disease Research Center. She received her PhD from the University of Michigan in biopsychology and completed a post-doctoral fellowship in cognitive neuroscience at the University of California, Davis. She has been a faculty member at Rush Medical College since 1999. Dr. Barnes has received many NIH grants and has published over 300 manuscripts. Her research interests include disparities in chronic diseases of aging, cognitive decline, and risk factors for Alzheimer's disease. She is the Principal Investigator of the Minority Aging Research Study (MARS), which has been funded by NIA since 2004, and the Clinical Core Leader for the Rush African American Clinical Core. She advocates for recruitment of under-represented groups into clinical studies and has received many awards and fellowships. Episode produced by: Rasa Valiauga Episode recording date: 8/21/23 www.medicuspodcast.com | medicuspodcast@gmail.com | Donate: http://bit.ly/MedicusDonate --- Send in a voice message: https://podcasters.spotify.com/pod/show/medicus/message
Discover the reality behind the expectations of rare disease research and drug development with Isabel and Jade as they present a discussion with Dr Ian Winburn, Vice President, Global Lead for Rare Hematology, Pfizer. Tune in to hear Ian and Isabel discuss the current pharmaceutical landscape for rare diseases, including discussions around clinical trials, partnering early in the drug lifecycle, what the industry should be keeping in mind for the future of the field and much more. If you're interested in learning more about the topic areas discussed in this episode, check out the following content: Mitigating the rare disease RWD deficit Last week's podcast: Do happy employees equal better innovation
This 30-min CME program provides an overview of the latest clinical research presented at ENDO 2023 involving Cushing's disease.FacultyLisa Nachtigall, MDClinical Director, Neuroendocrine & Pituitary Tumor Clinical CenterMassachusetts General HospitalAssociate Professor of MedicineHarvard Medical SchoolLearning Objectives- After participating in the activity, learners should be better able to:- Describe the latest research being presented to better manage individuals with Cushing's disease and its clinical relevance.- Share new information with their clinical team.Supported by an educational grant from Recordati Rare Diseases, Inc.To obtain CME credit, go to https://checkrare.com/learning/p-cushings-disease-research-highlights-endo-2023/
Welcome to this week's episode of Fast. Feast. Repeat. Intermittent Fasting for Life, with Gin Stephens and Sheri Bullock.To make a submission for the podcast, go to fastfeastrepeat.com/submit. We are a community-driven podcast, and we look forward to sharing your questions, success stories, non-scale victories, IF tweaks, motivational quotes (and more!) on each episode of the podcast. Resources used in today's episode: https://www.beautycounter.com/sheribullock https://www.sciencedirect.com/science/article/pii/S1550413123002735?via%3Dihub Go to fastfeastrepeat.com to see Gin's and Sheri's favorite things, and to shop with us. Every purchase you make through links on our website help to support this podcast so we can keep bringing you episodes each week. Are you ready to take your intermittent fasting lifestyle to the next level? There's nothing better than community to help with that. In the Delay, Don't Deny community we all embrace the clean fast, and there's just the right support for you as you live your intermittent fasting lifestyle. Connect with both Gin and Sheri in the community, as well as thousands of other intermittent fasters who are there to support you along your journey. If you're new to intermittent fasting or recommitting to the IF lifestyle, join the 28-Day FAST Start group. After your fast start, join us for support in The 1st Year group. Need tips for long term maintenance? We have a place for that! There are many more useful spaces beyond these, and you can interact in as many as you like.Visit ginstephens.com/community to join us. An annual membership costs just over a dollar a week when you do the math. If you aren't ready to fully commit for a year, join for a month and you can cancel at any time. If you know you'll want to stay forever, we also have a lifetime membership option available. IF is free. You don't need to join our community to fast. But if you're looking for support from a community of like-minded IFers, we are here for you at ginstephens.com/community.This show is part of the Spreaker Prime Network, if you are interested in advertising on this podcast, contact us at https://www.spreaker.com/show/5913143/advertisement
This episode is truly a thought-provoking conversation about Alzheimer's and its unique impact on women with none other than the legendary Dr. Dale Bredesen (who is making his fourth appearance on the show). Dale Bredesen, MD, received his undergraduate degree from Caltech and his medical degree from Duke University. He served as resident and chief resident in neurology at the University of California, San Francisco (UCSF) and as postdoctoral fellow in the laboratory of Nobel Laureate Professor Stanley Prusiner. He was a faculty member at UCLA from 1989 to 1994 and was then recruited by the Burnham Institute to direct the Program on Aging. In 1998, he became the founding president and CEO of the Buck Institute for Research on Aging and adjunct professor at UCSF. In 2013, he returned to the University of California, Los Angeles (UCLA) as director of the Easton Center for Alzheimer's Disease Research and he is currently a professor.Dr. Stephanie and Dr. Bredesen delve into the fascinating topic of Alzheimer's as a preventable condition, emphasizing that this is the first generation with the power to make Alzheimer's truly optional. They explore the shift in the common presentation of Alzheimer's, particularly in women, highlighting the rise of subjective or mild cognitive impairment in 52-year-old women.As always, Dr. Stephanie and Dr. Bredesen provide actionable solutions for preventing and managing Alzheimer's, covering diet, exercise, sleep, supplementation, and testing. They introduce innovative blood tests, discuss the importance of a "cognoscopy," and even touch on dental health's role in brain health.Resources Mentioned:Reversal of Cognitive Decline: 100 Patients - https://www.omicsonline.org/open-access/reversal-of-cognitive-decline-100-patients-2161-0460-1000450-105387.htmlTranscriptional Effects of ApoE4: Relevance to Alzheimer's Disease - Transcriptional Effects of ApoE4: Relevance to Alzheimer's DiseaseReCODE: A Personalized, Targeted, Multi-Factorial Therapeutic Program for Reversal of Cognitive Decline. - https://pubmed.ncbi.nlm.nih.gov/34680464/Could Alzheimer's disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism? - https://pubmed.ncbi.nlm.nih.gov/36774227/Reversal of cognitive decline: a novel therapeutic program - https://pubmed.ncbi.nlm.nih.gov/25324467/Reversing the effects of Alzheimer's Disease: Dr. Ron Geyer on NeuroEPO - https://medicine.usask.ca/news/2023/reversing-the-effects-of-alzheimers-disease-dr.-ron-geyer-on-neuroepo.phpDr. Bredesen's TedX talk - https://youtu.be/TzJSCttlQmc?si=sEC_psvctDR0XRkzDr. Bredesen's books - https://www.apollohealthco.com/books/KetoFLEX 12/3™ - https://ketoflex.apollohealthco.comEvanthea Dementia Reversal Trial - https://www.dementiareversaltrial.comInstagram - https://www.instagram.com/drdalebredesen/Episode Overview:0:00:00 Introduction0:05:42 Welcome to Dr. Dale Bredesen0:11:59 Factors driving the shift in Alzheimer's disease onset age0:15:41 COVID-19 and Alzheimer's disease risk0:21:28 The importance of addressing chronic conditions0:24:01 The role of metabolic health in cognitive decline0:25:40 The role of diet in Alzheimer's disease0:26:54 The postmenopausal women and cognitive decline0:35:05 Alzheimer's disease and genetic factors0:36:53 How we could confuse perimenopause with Alzheimer's0:44:39 ApoE4 and the evolution of hominids0:47:42 ApoE4 and its pro-inflammatory effect0:51:23 The limitations of targeting neurofibrillary tangles and plaques0:54:23 Evaluating the efficacy of drugs for Alzheimer's treatment1:04:39 Exploring the use of supplementation in the trial1:05:45 The seven fundamentals for maintain good brain health1:13:57 Importance of sleep hygiene and nasal breathing1:18:38 Tailoring sleep habits to circadian rhythms and environmental factorsWe'd like to thank our sponsors:Go to neurohacker.com/better to try Qualia Senolytic with a 100 day money back guarantee, and code BETTER will get you 15% off your order.Right now Levels is offering you an additional two free months off of the levels annual membership when you use the link levels.link/better.If you want to try Beam Minerals for yourself, head over to beamminerals.com/better for 20% off of the entire store.
Good morning from Pharma and Biotech daily: the podcast that gives you only what's important to hear in Pharma and Biotech world.In our first news, we have a summary of an on-demand webinar that discusses how real-world data (RWD) can be leveraged in rare disease research. The use of RWD in clinical trials and drug development for rare diseases is explored by experts from Pfizer and Clarivate. They highlight the importance of RWD in narrowing the gap of knowledge surrounding rare diseases and how it can enhance clinical trials and improve drug development processes. Challenges associated with harnessing RWD effectively are also addressed, along with best practices for overcoming these obstacles. The goal is to optimize rare disease research by leveraging RWD and improving drug development efficiency.Moving on to our next news, we have a promotion for an on-demand webinar titled "High-Throughput Process & Analytical Platforms to Accelerate Gene Therapy Scale-Up." This webinar discusses various topics related to gene therapy scale-up and how innovative platforms can revolutionize the process. Some key points covered include serotype agnostic analytics for AAV manufacturing, challenges in scaling up to larger bioreactors, using an advanced platform with a reduced number of plasmids, and Resilience and Lacerta's innovations. Experts in the field share their insights, and interested individuals can connect with the Resilience team for support in gene therapy process and analytical development work.In regulatory news, the FDA has placed a partial clinical hold on two studies of Innate Pharma's investigational therapy lacutamab following a patient death from the rare blood disease hemophagocytic lymphohistiocytosis. Innate Pharma is working closely with the FDA to address the agency's concerns and provide the necessary data. In other news, an FDA advisory committee has backed the use of US WorldMeds' investigational drug for high-risk neuroblastoma, despite the lack of a randomized controlled trial. This decision could set a precedent for future drug approvals without randomized controlled trial data. Japan-based pharma company Kyowa Kirin is also acquiring Orchard Therapeutics pending regulatory approvals, and Johnson & Johnson's spravato has shown promising results in a phase III head-to-head study.Shifting gears to marketing and advertising, we discuss the importance of connected TV for marketers and how the Hollywood shutdown could disrupt the ad market. Disney's innovative holiday marketing strategies are highlighted, along with Olaplex's unique approach to addressing dupe culture on TikTok. Three Olives Vodka is mentioned for using AI to plan the perfect party, and Meta (formerly known as Facebook) is expanding access to its generative AI tools. Target has launched an immersive toy experience for online shoppers, allowing them to explore a virtual room of products.In the rare disease space, we delve into regulatory challenges related to the use of biomarkers to measure efficacy. The FDA recently approved Novo Nordisk's drug rivfloza for patients with primary hyperoxaluria, but there are concerns about shortcomings in regulatory policies when it comes to biomarkers for rare diseases. Leaders in the pharmaceutical industry who are skilled at translating scientific research into products that regulators see value in are recognized on this year's Pharmavoice 100 list.Lastly, we address the challenges faced by health systems in their workforce due to a volatile economy. Burnout and high turnover rates persist despite efforts to raise wages and strengthen hiring. The nursing shortage is a major issue, and efforts are being made to address the gender pay gap among physicians. On a positive note, there has been a record number of residency matches for 2023, providing insights into current labor trends in healthcare.That wraps up today's episode of Pharma and Biotech daily. Stay tuned for more important news and updates in
ONCE UPON A GENE - EPISODE 200 Fundraising Strategies for Patient Advocacy Organizations Raising Money for Rare Disease Research with Lindsay Stevens Lindsay Stevens is a CTNNB1 mom and a skilled fundraiser who has harnessed her passion and expertise to rally support for CTNNB1 research initiatives. She joins me for a discussion about the art of fundraising and how the smallest efforts can spark profound change. EPISODE HIGHLIGHTS Can you share about yourself and your family? I'm a mom of three children, two typical children and my youngest who was diagnosed with CTNNB1 at about two and a half years old. In my work life, I work for a nonprofit and I'm well-versed in all things fundraising. Why is fundraising crucial for advancing medical research and why is it important for families to get involved? It's up to us as parents to make a grassroots movement and if we're going to approach researchers to find treatments for our kids, they need the financial support to do that. What can parents do to contribute to fundraising goals and maximize contributions? Think about what your skills are and how you can contribute and make a change— writing letters to people you know, advocating, coordinating fundraising events, or something else. Parents need to think about who they know in their personal network where fundraising can come from. If someone is making a gift, it's possible that the company they work for will match the gift. Grandparents want to help and if they're at the age that they need to take disbursements from their IRA's, they can gift it to a nonprofit and avoid tax penalties. Parents can write a letter outlining fundraising goals and make an appeal to people they are sending holiday cards to. Communicate within your network at different milestones throughout the year like at the end of the school year or when the school year resumes, provide updates about your child and ask for a contribution. If someone makes a gift, take the time to write a hand-written thank you note, because acknowledging a gift is just as important as asking for one. LINKS & RESOURCES MENTIONED Dante Labs https://us.dantelabs.com/ Email Lindsay lindsayannstevens@gmail.com CTNNB1 Connect and Cure Podcast https://www.curectnnb1.org/podcast/ TUNE INTO THE ONCE UPON A GENE PODCAST Spotify https://open.spotify.com/show/5Htr9lt5vXGG3ac6enxLQ7 Apple Podcasts https://podcasts.apple.com/us/podcast/once-upon-a-gene/id1485249347 Stitcher https://www.stitcher.com/podcast/once-upon-a-gene Overcast https://overcast.fm/itunes1485249347/once-upon-a-gene CONNECT WITH EFFIE PARKS Website https://effieparks.com/ Twitter https://twitter.com/OnceUponAGene Instagram https://www.instagram.com/onceuponagene.podcast/?hl=en Built Ford Tough Facebook Group https://www.facebook.com/groups/1877643259173346/ Interested in advertising on Once Upon a Gene? Email advertisi ng@bloodstreammedia.com for more information!
Join Michael and mom as they talk candidly to Rob Long, former football star at Syracuse, brain cancer survivor, literally beating every odd, and now Executive director of Uplifting Athletes. He turned his very dismal brain cancer diagnosis into a new path, to help others going through rare disease. Uplifting Athletes raises money and awareness to fund research for rare diseases, enhances student athlete life skills development and rare disease patient engagement. In Rob's words: "As a rare disease survivor I have the opportunity to help others as so many have helped me." Michael and ashlee loved every moment of this very special interview. Rob is an inspiration and we know you will be inspired by his words of wisdom and kindness, as he so humbly shares his story of his rare brain cancer and how he survived. Uplifting Athelestes: https://www.upliftingathletes.org/ instagram: https://www.instagram.com/roblong47/ Linked in: https://www.linkedin.com/in/roblong47/ #cancersurvivor #cancer #braincancer #podcast #gratitude #upliftingathletes #cancerresearch
I had the pleasure of sitting down with clinical psychologist Dr. Genifer Goldsmith to discuss the immense stress and guilt that comes with being a caregiver. Our collaboration in co-facilitating a caregiver support group at UCLA for Alzheimer's Disease Research and care has been nothing short of enlightening. As someone who facilitates a caregiver support group, we see these struggles firsthand. Dr. Goldsmith provides research-backed insights on how to cope. One key element emerges as a cornerstone to enhancing a patient's journey: caregiver support. Join us as we unpack the pivotal role caregivers play and discover the profound difference they can make in the progression of dementia.Caregiving is an immense challenge, but small acts of self-care have a huge impact. Never feel guilty for supporting yourself first - it helps your loved one most. Timeline Summary:[02:20] - Stress as a caregiver and what it truly means.[03:00] - Craving structure within the chaos of unexpected changes in disease progression.[04:41] - Taking on unfamiliar roles alone like taxes and home repairs adds major stress.[06:35] - The heartbreak of taking away a loved one's independence and the balancing act between quality of life and safety.[09:15] - Conflict response: meet them in their reality and avoid conflict.[11:40] - Supporting caregivers directly impacts disease progression.[13:33] - Being a caregiver is like running a marathon.[14:22] - Feeling guilty about prioritizing yourself and how to change it.[16:20] - Largest percentage ever of older adults and the impact on the family unit.[17:03] - Comparing societal support for caregivers to new moms and how social media trends can help.[18:01] - “Being selfish is the most selfless thing a caregiver can do.”[18:35] - Well-supported caregivers slow disease progression.[20:15] - Setting up preventative measures to reduce caregiver burden.[21:31] - Being conscious of your tone.[23:00] - Start small with 10 minutes of self-care when overwhelmed. Do you have a caregiving story to share? Barbara would love to hear from you! Please leave her a message at 310-362-8232 or send her an email through DementiaDiscussions.net.If you found value in today's episode, please don't forget to rate, follow, share, and leave a review. Your feedback helps us reach more listeners and continue producing this content.
Dr Dale Bredesen has demonstrated that we have entered into the new era of Alzheimer's care, and that we are already amongst the horrible disease's first survivors. He makes an incredibly bold statement that getting Alzheimer's disease is “truly optional”. Wow! What an incredible message of self-empowerment and hope. We need this episode more than ever to provide the increasing number of people and their families impacted by Alzheimer's hope and that they can get their mind back and therefore their life back.Dale E. Bredesen, MD, received his undergraduate degree from Caltech and his medical degree from Duke University. He served as resident and chief resident in neurology at the University of California, San Francisco (UCSF) and as postdoctoral fellow in the laboratory of Nobel Laureate Professor Stanley Prusiner. He was a faculty member at UCLA from 1989 to 1994, and was then recruited by the Burnham Institute to direct the Program on Aging. In 1998, he became the founding president and CEO of the Buck Institute for Research on Aging and adjunct professor at UCSF. In 2013, he returned to the University of California, Los Angeles (UCLA) as director of the Easton Center for Alzheimer's Disease Research.The Bredesen Laboratory studies basic mechanisms underlying the neurodegenerative process and the translation of this knowledge into effective therapeutics for Alzheimer's disease and other neurodegenerative conditions, which has led to the publication of over 200 research papers. He is the principal investigator for the Alzheimer's Disease Research Center at UCLA. He established the ADDN (Alzheimer's Drug Development Network) with Dr. Varghese John in 2008, leading to the identification of new classes of therapeutics for Alzheimer's disease. His group has developed a new approach to the treatment of Alzheimer's disease, the MEND protocol, and this approach has led to the first description of a reversal of symptoms in patients with mild cognitive impairment (MCI) and early Alzheimer's disease.Join us as we explore:The forefront of both Alzheimer's disease research and treatment, and why most neurologists are stuck in the past and ineffective treatment, including stories from Dr Bredeson's new book detailing how his approach has already reversed Alzheimer's disease in his patients.The 7 fundamental pieces of Alzheimer's prevention and treatment, including treating the vicious prionic loop.Why everyone over 40 needs to do a “cognoscopy”, and don't worry it's a lot more pleasant than a colonoscopy! Dr Bredeson's research and experimentally backed theory that neurodegenerative diseases are about a gap between supply and demand in your brain's network capabilities, and if you can't reduce the demand how you can increase your brain supply, and how his approach treats the disease at the root which is NOT in the brain itself.The critically important message of hope that even though your biological systems may get dysfunctional over time, they are incredibly resilient and able to reverse themselves to good health if we implement the fundamental basics of functional and natSupport the showSupport the show on Patreon:As much as we love doing it, there are costs involved and any contribution will allow us to keep going and keep finding the best guests in the world to share their health expertise with you. I'd be grateful and feel so blessed by your support: https://www.patreon.com/MadeToThriveShowSend me a WhatsApp to +27 64 871 0308. Disclaimer: Please see the link for our disclaimer policy for all of our content: https://madetothrive.co.za/terms-and-conditions-and-privacy-policy/
How can we ensure that all communities are represented in Alzheimer's and related dementias research and have access to the latest treatments and interventions? Dr. Carl Hill, the chief diversity, equity and inclusion (DEI) officer for the Alzheimer's Association, joins the podcast to delve into the significance of representation, diversity, equity, equality and inclusion within Alzheimer's disease research. He discusses the challenges of underrepresentation in clinical trials, the importance of community-based participatory research (CBPR) and the social determinants of health that influence Alzheimer's risk. Guest: Carl V. Hill, PhD, MPH, chief diversity, equity and inclusion officer, Alzheimer's Association Show Notes Learn more about the Alzheimer's Association's effort in DEI from their inaugural DEI report. Learn more about race-related topics in Alzheimer's disease from the Alzheimer's Association International Conference (AAIC) 2022 here, including a study on the impact of racism on the brain and findings on racial disparities in health equity and resources in Black and Brown communities. Listen to Dr. Hill's past episodes of Dementia Matters, “Scientific Importance Of Diversity In Alzheimer's Disease Research,” and, “Battling Health Disparities In Aging Research And Care,” on our website. Learn more about Dr. Hill in his bio on the Alzheimer's Association's website. Connect with us Find transcripts and more at our website. Email Dementia Matters: dementiamatters@medicine.wisc.edu Follow us on Facebook and Twitter. Subscribe to the Wisconsin Alzheimer's Disease Research Center's e-newsletter.
Neuro Pathways: A Cleveland Clinic Podcast for Medical Professionals
Ignacio Mata, PhD, discusses ongoing research that seeks to elucidate the role of women-specific health factors in the severity and progression of Parkinson's disease. This activity is approved for
In this episode Erica recaps some of her favorite celiac disease research (and more) from Digestive Disease Week 2023. Learn about the advances in a cure for celiac disease with upcoming clinical trials for KAN-101, DONQ52 and more. Included is an interview with Dr. Jason Tye-Din about clinical trials for celiac disease research, new drugs, and the possibility to test for celiac disease without a gluten challenge (in the future). RESOURCESCeliac Disease Foundation 2023 DDW Wrap-upBeyond Celiac 2023 DDW ResearchCeliac disease drugs show progress from Beyond CeliacStudy: OAT AVENIN TRIGGERS ACUTE SYMPTOMS AND IMMUNE ACTIVATION IN SOME PEOPLE WITH CELIAC DISEASE BUT ADVERSE IMMUNE AND CLINICAL EFFECTS ARE ABSENT WITH EXTENDED INGESTIONStudy: KAN-101: PHARMACODYNAMIC DEMONSTRATION OF IMMUNOLOGICAL TOLERANCE INDUCED BY KAN-101, A NOVEL LIVER-TARGETED THERAPY FOR CELIAC DISEASE, PERSISTS FOLLOWING DRUG CLEARANCEStudy: DONQ52: A BISPECIFIC ANTIBODY TARGETING HLA-DQ2.5-GLUTEN PEPTIDES POTENTLY BLOCKS GLUTEN-SPECIFIC T CELLS INDUCED BY GLUTEN INGESTION IN PATIENTS WITH CELIAC DISEASEEating disorders and IBS studyDating with Celiac Disease from Dr. Jessica Lebovitz on Celiac and the Beast's InstagramContact/Follow Jules & Erica Tweet us @THEgfJules & @CeliacBeast Find us on IG @CeliacandTheBeast & @gfJules Follow us on FB @gfJules & @CeliacandTheBeast Email us at support@gfJules.com Find more articles, recipes & info at gfJules.com & celiacandthebeast.com Thanks for listening! Be sure to subscribe!**some links may be affiliate links; purchasing through these links will not cost you more, but will help to fund the podcast you ❤️
The launch of the Simpson Querrey Lung Institute for Translational Science (SQLIFTS) at Northwestern University Feinberg School of Medicine aims to expedite the discovery and implementation of innovative lung disease treatments through a patient-centered approach. In this episode, Scott Budinger, MD, the new executive director of the institute, discusses its launch and how it aims to transform lung disease research and clinical care.
This episode is dedicated to the memory of my mother-in-law, Judith Kruse, who passed away 5 years ago this week with dementia. She was filled with joy & laughter & we miss her dearly.My guest today is world expert on Alzheimer's, Dr. Dale Bredesen. He is truly changing the world of Alzheimer's Disease Research and is an internationally recognized expert in the mechanisms of neurodegenerative diseases.Dr. Bredesen's research explores previously uncharted territory in explaining the physical mechanism behind the erosion of memory seen in Alzheimer's disease, and has opened the door to new approaches to treatment. This work has led to the identification of several new therapeutic processes that are showing remarkable early results. Notably, he put much of his findings and research into the 2017 New York Times‘ Best-Seller, The End of Alzheimer's available anywhere you buy books or you can grab it on Amazon Canada or Amazon US.His most recent book, The First Survivors of Alzheimer's, presents the stories of seven individuals who reversed their cognitive decline using the ReCODE Protocol.In this episode, Dr. Bredesen & I cover off:- What are the many causes of cognitive decline?- What genetics are involved & how to find out if you carry these genes?- How can one improve cognition now before any major issue arises?- Are you doomed if you're noticing cognitive decline?- Can Alzheimer's really be reversed?And SO much more in this packed-with-information episode.Find out more about the solutions for Cognitive Decline here:https://www.apollohealthco.com/solutions/Free assessment to find out your CQ (Cognitive Quotient) here: https://www.apollohealthco.com/know-your-cq/Get a Cognoscopy:mycognoscopy.comSHARE this episode with someone who may benefit & subscribe, rate & review. And follow me below!Instagram: https://www.instagram.com/sandyknutrition/Facebook Page: https://www.facebook.com/sandyknutritionTikTok: https://www.tiktok.com/@sandyknutritionYouTube: https://www.youtube.com/channel/UCIh48ov-SgbSUXsVeLL2qAgTwitter: https://twitter.com/sandyknutrition
Minnesota scientists have watched chronic wasting disease — a fatal, neurological illness — kill deer and elk. Now, they're studying its potential to jump to humans. The University of Minnesota's Center for Infectious Disease Research and Policy has received more than $1.5 million in state money to start prepping for the possibility of CWD spreading to cows, pigs and possibly humans. Michael Osterholm, PhD. is a world-renowned epidemiologist and heads the University of Minnesota Center for Disease Research and Policy. He talked with MPR News host Cathy Wurzer.
The ultimate tour de force of human strength, endurance, mental toughness, and unyielding perseverance. That's what this week's Team Never Quit Podcast guest, Mike McCastle is. Listen in as Mike and Marcus engage in a discussion about Mike's seemingly unbelievable feats he refers to as "labors". Endurance athlete - yes; Multiple world record holder - you know it; In-demand performance coach - for sure; Motivational speaker - of course. After serving 11 years in the U. S. Navy, he founded Twelve Labors Project, a charitable initiative driven by a mission to redefine the limits of human potential while inspiring others to elevate beyond their perceived capacity for greatness. Mike is perennially challenging his own physical and mental limits, and he's not anywhere near done yet. In this podcast, he reveals his upcoming 9th labor, and it will blow you away when you hear it. Mike's 8 charitable labors he has accomplished so far include: A 50k run while wearing a 40lb vest for Cancer Research. A 13-mile, 250-pound tire flip for wounded veterans. A Rope Climb that equaled the height of Mount Everest - 29,029 feet in 27 hours for Parkinson's Disease Research. Breaking the Guinness World Record for 'Most Pull-ups in 24 hours after completing 5,804 pull-ups, while wearing a 30-pound pack to represent the heavy burden of the wounded warrior. Pulled a Ford F-150 pickup truck for 22 miles in 19 hours across Death Valley to raise awareness for Veteran Suicide. Ran 20 miles per day for 100 consecutive days to heighten awareness of the Veteran Suicide epidemic. Pulled a full-size pickup truck for 10 miles through the Arctic Circle. Broke the world record for the longest full-body submersion in ice (2 hours and 40 minutes). In this episode you will hear: I basically grew up in a cornfield. I went to BUDS (Navy SEAL Training) and blew my knees out. Then I needed to re-find my purpose because my one-man pity party wasn't working for me. My dad's Parkinson's started to progress, and one day I came home and he was on the floor. He had had a stroke. I decided to take care of my dad and stop the pursuit of sports. But in my mind, I quit. You can fool other people, but you can never fool yourself. Things that pull you away from your purpose are those are things behind the doors in your hallway of life. You're tested, dragged through the fire, and you feel like you're cursed but you still have a choice. If you put all your eggs in one basket and when it gets taken away from you, you're left with nothing. Then who the hell am I? I needed to find my purpose again. That's how The Twelve Labors Project got started. I wanted to create a physical manifestation of the message I wanted to deliver. It's not a weakness to be vulnerable. Finding your purpose in life requires risk. I don't give a shit about records. What I care about is “Is this going to deliver my message?” “Are people gonna remember WHY I did it?” Reality isn't what happens to us, it's our interpretation of what happens to us. We're all writing our own stories. You cannot only come back after failure, but you can come back stronger after failure. My father always said, "You suffer more in imagination than you do in reality." Finish what you started. If you're gonna do it, go all the way. We're all the heroes of our own story. You go through the crucible you come back, and you share the lessons learned. The reward for finishing a labor is the next labor. The internet is undefeated. Our time on this planet is very limited. The things we do echoes through eternity from the lens of your loved one. The only goal for my son is to leave this world a better place than he found it, like I hope I am doing and I hope that everyone who hears my message does. Follow Mike www.MikeMccastle.com https://www.instagram.com/mikemccastle/ Follow TNQ: https://www.instagram.com/marcusluttrell/ https://www.instagram.com/andrewbrockenbush/ https://www.instagram.com/team_neverquit/
As we wait for the final results of the midterm elections to determine which party will control the House, enjoy Jen's interview with C-SPAN Communications Director, Howard Mortman. Jen and Howard discuss all things C-SPAN, including what C-SPAN crews are and are not allowed to film and the network's funding sources and distribution, as well has Howard's podcast, the Weekly, and his book, When Rabbis Bless Congress. Please Support Congressional Dish – Quick Links Contribute monthly or a lump sum via PayPal Support Congressional Dish via Patreon (donations per episode) Send Zelle payments to: Donation@congressionaldish.com Send Venmo payments to: @Jennifer-Briney Send Cash App payments to: $CongressionalDish or Donation@congressionaldish.com Use your bank's online bill pay function to mail contributions to: 5753 Hwy 85 North, Number 4576, Crestview, FL 32536. Please make checks payable to Congressional Dish Thank you for supporting truly independent media! View the shownotes on our website at https://congressionaldish.com/cd262-inside-c-span-with-howard-mortman Executive Producer Recommended Sources Ecomodernist Society of North America CD261: Inflation Reduction Act CD258: Gain of Function Research Background Sources Howard Mortman Howard Mortman Bio C-SPAN's The Weekly Podcast Book: When Rabbis Bless Congress: The Great American Story of Jewish Prayers on Capitol Hill On Twitter @HowardMortman Jen on C-SPAN Washington Journal, August 9, 2019 Washington Journal, September 10, 2022 Alzheimer's Testimony Seth Rogan's and Charity “Alzheimer's Disease Research.” February 26, 2014. Senate Appropriations Subcommittee on Labor, Health, and Human Services. Hilarity for Charity (HFC) Origins of COVID-19 Katherine Eban and Jeff Kao. October 28, 2022. “COVID-19 Origins: Investigating a ‘Complex and Grave Situation' Inside a Wuhan Lab.” ProPublica. Cover Art Design by Only Child Imaginations Music Presented in This Episode Intro & Exit: Tired of Being Lied To by David Ippolito (found on Music Alley by mevio)
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