Podcasts about Chief scientific officer

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Best podcasts about Chief scientific officer

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Latest podcast episodes about Chief scientific officer

Foundation for Science and Technology
Dr Kath MacKay - Life sciences in the UK

Foundation for Science and Technology

Play Episode Listen Later Mar 2, 2026 26:06


This week we are discussing life sciences in the UK, and its contribution to the UK economy. This follows the publication by the Government of the Life Sciences Sector Plan and an event on life sciences which the Foundation for Science and Technology held on 12th November. With us to explore all things life sciences is Dr Kath MacKay, Chief Scientific Officer of Bruntwood SciTech.

Smart Money Circle
This Biotech CEO Is Using AI To Help Accelerate Antibody Discovery…

Smart Money Circle

Play Episode Listen Later Feb 25, 2026 16:11


Guest: Martin Brenner, Ph.D., Chief Executive Officer and Chief Scientific Officer at iBioCompany: iBio, Inc. (NASDAQ:IBIO)Website: https://ibioinc.com/Martin's Bio:Dr. Brenner has a strong history of success heading drug discovery and development teams at several of the world's leading pharmaceutical companies, including AstraZeneca, Eli Lilly and Company, Pfizer Inc., and Merck Research Laboratories. Most recently, Dr. Brenner served as the CSO at Pfenex Inc., which, using its patented Pfēnex Expression Technology® platform, created an advanced pipeline of therapeutic equivalents, vaccines, biologics and biosimilars. Pfenex was acquired by Ligand Pharmaceuticals Incorporated for approximately $516 million in October 2020. Previously, Dr. Brenner served as the CSO at Recursion Pharmaceuticals, Inc., a company focused on accelerating drug discovery for rare diseases and diseases with high unmet medical need. Prior to his time at Recursion, he was Vice President and Head of Research & Early Development at Stoke Therapeutics, Inc., a biotechnology company using antisense oligonucleotides to increase gene expression for the treatment of rare diseases. Prior to Stoke, he was Executive Director at Merck, where he built a biotech unit from scratch, focusing his team's research on diabetes and nonalcoholic steatohepatitis (NASH). Earlier in his career, Dr. Brenner was the Senior Director and Head of cardiovascular, renal, and metabolism (CVRM) biosciences at AstraZeneca. In addition, Dr. Brenner was an Associate Research Fellow at Pfizer where he led the islet biology and in vivo pharmacology in the CVMED Target Exploration Unit before assuming the role of Head of the Insulin Resistance Group.Company Description: iBio is a cutting-edge biotech company leveraging AI and advanced computational biology to develop next-generation biopharmaceuticals for cardiometabolic diseases, obesity, cancer and other hard-to-treat diseases. By combining proprietary 3D modeling with innovative drug discovery platforms, iBio is creating a pipeline of breakthrough antibody treatments to address significant unmet medical needs. iBio's mission is to transform drug discovery, accelerate development timelines, and unlock new possibilities in precision medicine.

Digital Health in Canada
Health Data Sovereignty: Systems, Safeguards, Strategy

Digital Health in Canada

Play Episode Listen Later Feb 23, 2026 36:03


What does it take to protect a key strategic asset— our health data — in an era of accelerating AI? In this episode, we explore why data sovereignty is a strategic imperative for Canada, and the digital health future we stand to build — or lose. Guests:  Dr. Kumanan Wilson, Specialist in General Internal Medicine at The Ottawa Hospital; Chief Executive Officer/Chief Scientific Officer, Bruyère Health Research Institute; Vice President Research & Academic Affairs, Bruyère Health; and Chief Scientific Officer of CANImmunize Inc. Michael Geist, Canada Research Chair in Internet and E-Commerce Law at the University of Ottawa. Learn More: Ensuring the sovereignty and security of Canadian health data The catch-22 of Canadian digital sovereignty e-Health Conference and Tradeshow Summary: 00:00 Why Canada's health data matters in the age of AI 01:41 Kumanan's journey: from public health to building an immunization app 03:38 Michael Geist's path: law, tech policy, privacy & data 05:22 Defining data sovereignty 09:40 When laws collide 15:27 Health benefit vs economic benefit 20:43 Practical safeguards and strategies 26:23 Learning from global examples 30:15 Closing reflections Music: RetroFuture Clean and Breakdown, by Kevin MacLeod. Used under Creative Commons.  

Foundation for Science and Technology
Professor David Nutt - The science behind substance and addiction

Foundation for Science and Technology

Play Episode Listen Later Feb 23, 2026 21:18


This week we are discussing the science behind substance and addiction- the impacts of alcohol on the brain and contemporary alternatives, and how psychedelic research and brain science is being combined to tackle depression, addiction and anxiety. With me to explore this is Professor David Nutt, Professor of Neuropsychopharmacology at Imperial College London and Chief Scientific Officer at GABA Labs.

Careers in Discovery
Marc Damelin, Alphina Therapeutics

Careers in Discovery

Play Episode Listen Later Feb 18, 2026 37:26


In this episode of Careers in Discovery, Tyler is joined by Marc Damelin, Chief Scientific Officer at Alphina Therapeutics. Marc shares his journey from physics undergraduate to Biotech leader, and how a love of problem‑solving gradually drew him from yeast genetics into human disease and ultimately into drug development. After a decade in big pharma working on antibody–drug conjugates, he steps into Biotech leadership, first at Mersana and now at Alphina, where he's pioneering a new class of ADCs built around NAMPT inhibition. Along the way, Marc reflects on choosing industry without having a clear plan, understanding what makes a role the right fit, and why being truly data‑driven is one of the most important habits a scientist can develop. An open, forward‑looking conversation about evidence, judgment and the momentum that comes from backing the right ideas at the right time.

Conscious Fertility
143: Resveratrol & IVF: Does It Hurt Implantation? New Research Explained Dr. Mark Ratner

Conscious Fertility

Play Episode Listen Later Feb 16, 2026 36:09


In this follow-up conversation, Dr. Lorne Brown sits down again with Dr. Mark Ratner, Chief Scientific Officer at Theralogix, to revisit the controversy surrounding resveratrol and IVF outcomes.After a 2019 study suggested resveratrol might reduce implantation rates, Dr. Ratner conducted a deep dive into the latest research — including four newer prospective randomized trials and a recent study on pterostilbene.The result? A very different picture.This episode breaks down what the science actually says about egg quality, implantation, miscarriage risk, and live birth outcomes — and whether resveratrol truly poses a risk during IVF.Key Takeaways:The 2019 resveratrol study was retrospective and had significant baseline differences between groups.Four newer prospective randomized trials show no reduction in pregnancy rates with resveratrol.Multiple studies report improvements in egg quality, embryo quality, and fertilization rates.SIRT1 plays a central role in ovarian reserve and uterine receptivity.Pterostilbene, a better-absorbed analog, restored implantation and live birth rates in aging mice.Dr. Mark Ratner's Bio:Dr. Ratner is a board-certified urologist and the Chief Science Officer of Theralogix, a Washington, DC based company which markets micronutrient supplements with a focus on reproductive health. Dr. Ratner did his undergraduate and graduate studies in nutrition at Cornell University. He received his M.D. and residency training at Tulane University School of Medicine.Where to find Dr. Mark Ratner:Website: https://theralogix.com/Special Offer: https://theralogix.com/discount/LORNE?redirect=/products/ovanad Ian Kent - VP, Sales & Business Development

Beyond Biotech - the podcast from Labiotech
Using AI to crack undruggable drug targets

Beyond Biotech - the podcast from Labiotech

Play Episode Listen Later Feb 13, 2026 32:58


As we mark the International Day of Women and Girls in Science, we welcome Avital Sharir-Ivry, Co-Founder and Chief Scientific Officer of ProPhet, an innovative Israeli startup launched in late 2024 from the AION Labs venture studio.With a PhD in computational biology and drug research, Avital brings deep expertise in structural biology, enzyme design, and evolutionary bioinformatics to her role leading ProPhet's scientific efforts.ProPhet itself is changing small molecule drug discovery by using advanced AI and machine learning to map proteins and compounds into a shared interaction space. This enables rapid, scalable screening of billions of molecules—even for so-called "undruggable" targets—without relying on solved structures or massive datasets, speeding up hit-finding and expanding the reachable therapeutic landscape.01:36 Meet Avital Sharir-Ivry08:55 How ProPhet emerged from AION Labs challenge12:12 Core AI technology for hit-finding at scale15:00 Benchmarks and collaborations17:54 ProPhet's differentiation from traditional drug discovery19:45 Importance of scaling small molecule exploration24:19 Pharma AI investments and emerging trends26:11 Future AI breakthroughs in drug discovery27:04 Challenges and progress for women in science31:15 Keep up with ProPhetInterested in being a sponsor of an episode of our podcast? Discover how you can get involved here! Stay updated by subscribing to our newsletterTo dive deeper into the topic: Seven influential women in biotech in 2026 Report: Adopting AI in biologics discoveryWebinar: How AI and LLMs are helping chemists design drugs faster and smarter 

BioSpace
Digital Pathology, AI and the Future of ADCs and HER2 Cancer Treatment

BioSpace

Play Episode Listen Later Feb 12, 2026 23:11


In this episode of Denatured, Jennifer C. Smith-Parker speaks with Dr. Rob Monroe, Vice President and Chief Scientific Officer of Oncology at Danaher Corporation and Chief Medical Officer at Leica Biosystems, and Jennifer Fakish, Vice President and Franchise Head of Oncology at Danaher Corporation. We'll be discussing how antibody drug conjugates (ADCs) are transforming cancer care and with AI-powered pathology, doctors can now measure her HER2 more precisely to match patients with the best treatments. HostJennifer Smith-Parker, Director of Insights, BioSpaceGuestsDr. Rob Monroe, Vice President and Chief Scientific Officer, Oncology, Danaher Corporation; Chief Medical Officer, Leica BiosystemsJennifer Faikish, Vice President and Franchise Head, Oncology, Danaher CorporationDisclaimer: The views expressed in this discussion by guests are their own and do not represent those of their organizations.

Business of the V
Shining a Light on Vaginal Infections & Vaginal Health at Home with Ella Harris & Dr. Sonal Pendharkar Kulkarni of UVISA

Business of the V

Play Episode Listen Later Feb 5, 2026 28:08


What if you could rapidly relieve the symptoms of common vaginal infections like Bacterial Vaginosis (BV) & Candidiasis (Thrush) in the comfort of your own home? That is becoming a reality thanks to this week's guests, Ella Harris, Founder & CEO, and Dr. Sonal Pendharkar Kulkarni, Co-Founder & Chief Scientific Officer of UVISA. Hear how UV light can destroy only the bad bacteria in vaginal infections and support the regrowth of good bacteria. You will learn how the UVISA device works, the company's focus on user experience & comfort when it comes to vaginal health, and what's next for UVISA as a women's healthcare company. Tune in to this episode to have an up close look at a new era of vaginal infection care.   Learn more: UVISA UVISA LinkedIn Ella Harris Dr. Sonal Pendharkar Kulkarni   Today's Hot Flash and other stats from: UVISA

Lab Rats to Unicorns
Growing Human Tissue on Plants with Andrew Pelling_e.079

Lab Rats to Unicorns

Play Episode Listen Later Feb 4, 2026 52:34


In this episode of Lab Rats to Unicorns, John Flavin sits down with Dr. Andrew Pelling—trailblazing biophysicist, artist-trained scientist, and Co-Founder & Chief Scientific Officer of Spiderwort Biotechnologies. Andrew is best known for reimagining living systems, most famously by using decellularized apples and other plants as scaffolds to grow human tissue—work that helped spark an entirely new category of plant-derived biomaterials.Formerly a professor at the University of Ottawa, Andrew founded the Pelling Lab for Augmented Biology, an unconventional research environment where scientists and artists explored how physical forces—rather than genetic manipulation—shape cellular behavior. His approach focuses on stretching, compressing, and reshaping cells to unlock new biological possibilities.Andrew shares how his background in the arts shaped his scientific intuition, why curiosity-driven research led from grocery-store experiments to restoring movement in paralyzed rats, and how that breakthrough ultimately inspired the founding of Spiderwort. Along the way, he reflects on failure, leadership, and building imaginative teams—offering a compelling vision for how augmented biology could transform regenerative medicine and human health.

Cytokine Signalling Forum
Author Interview: Professor Matthew Brown, 2026

Cytokine Signalling Forum

Play Episode Listen Later Feb 3, 2026 18:29


Join Professor Peter Nash from the Griffith University in Brisbane, and Professor Matthew Brown, the Chief Scientific Officer at Genomics England, as they discuss his recent paper ‘Low uveitis rates in patients with axial spondyloarthritis treated with bimekizumab: Pooled results from Phase 2b/3 trials'.

EHS on Tap: The Podcast for EHS Professionals
E281: Reducing Workplace Injuries with Exoskeletons

EHS on Tap: The Podcast for EHS Professionals

Play Episode Listen Later Feb 3, 2026 23:38


On episode 281 of EHS On Tap, Dr. Karl Zelik, Co-founder and Chief Scientific Officer of HeroWear, talks about a new study on the use of exoskeletons in the workplace.

Redefining Medicine
Mitochondrial Function and Energy Resilience in Clinical Practice with Mitokatlyst | S. Dugar PhD

Redefining Medicine

Play Episode Listen Later Jan 30, 2026 25:00


In this episode of the Innovations and Clinical Implementation podcast, hosts Dr. Lexi Gonzales and Tom Blue interview Dr. Sundeep Dugar, a pharmaceutical drug hunter with nearly 40 years of experience in small molecule discovery who serves as the co-founder and Chief Scientific Officer at Blue Oak Nutraceuticals. The conversation focuses on the development of Mitocatalyst, a precision-formulated epicatechin designed to mimic the mitochondrial biogenesis normally triggered by exercise. Dr. Dugar reveals his breakthrough discovery that exercise-induced Reactive Oxygen Species (ROS) signal the mitochondria to produce a specific steroid—11-beta hydroxyprogesterone—and explains how Mitocatalyst utilizes nanomolar doses of epicatechin to molecularly mimic this steroid, distinguishing it from high-dose antioxidant protocols that paradoxically blunt these beneficial signals. The discussion uses the metaphor of building a "fireplace" (mitochondria) to burn "firewood" (nutrition), positioning the supplement as a critical intervention for aging patients or those unable to exercise. For access to episode resources: https://sites.google.com/ovationlab.com/innovationsinclinicalimplement/home

The Steve Gruber Show
The Steve Gruber Show | The Steve Gruber Show | The Psyop Exposed: Climate Lies, ICE Chaos, and Global Meddling

The Steve Gruber Show

Play Episode Listen Later Jan 28, 2026 113:16


The Steve Gruber Show | The Psyop Exposed: Climate Lies, ICE Chaos, and Global Meddling --- 00:00 - Hour 1 Monologue 16:18 – Dr. Michael Hutchison, inventor of the NeuroGuard+. Dr. Hutchison explains how this innovative mouth guard reduces the risk of concussion by more than 99 percent, with results tested and certified by Michigan State University and Wayne State University. He discusses why concussions remain one of the biggest concerns in sports and how NeuroGuard+ could be a game changer for athletes at every level. Visit neuroguardplus.com. 19:00 – Dudley Brown, President of the National Association for Gun Rights. Brown discusses growing friction between gun rights groups and Trump administration officials following a shooting in Minnesota. He explains where disagreements are emerging and what it could mean for Second Amendment advocacy. 28:00 – Dr. Peter A. McCullough, MD, MPH, Chief Scientific Officer at The Wellness Company. Dr. McCullough explains why Americans should consider stockpiling prescription medications alongside food and water during major emergencies. He also covers must-have prescriptions, first aid kits, and provides updates on flu and COVID trends this winter. Visit twc.health/GRUBER and use promo code GRUBER to save 10%. 38:40 - Hour 2 Monologue 47:04 – Dr. David Maimon, Head of Fraud Insights at Sentilink and known as the “Undercover Professor.” Dr. Maimon exposes a massive dark web crime ring draining hundreds of billions of dollars from the federal government. He explains how cybercriminals operate and why stopping them is increasingly difficult. 57:06 – William J. Watkins, Jr., constitutional law expert, practicing attorney, research fellow at The Independent Institute, and author of The Independent Guide to the Constitution. Watkins explains how the United States is testing the limits of federal power. He discusses constitutional boundaries and the long-term consequences of overreach. 1:15:40 - Hour 2 Monologue 1:34:24 – Rep. Parker Fairbairn, representing Michigan's 107th House District. Fairbairn discusses how mismanagement at MDHHS is threatening federal support for rural healthcare. He explains what's at stake for vulnerable communities across the state. 1:43:16 – Ivey Gruber, President of the Michigan Talk Network. Gruber talks about relentless winter weather, ice accumulation on the Hudson River, and why past climate change predictions have missed the mark. The segment also touches on DOGE efforts to root out waste, fraud, and abuse — and a reminder to stay away from wild animals. --- Visit Steve's website: https://stevegruber.com TikTok: https://www.tiktok.com/@stevegrubershow Truth: https://truthsocial.com/@stevegrubershow Gettr: https://gettr.com/user/stevegruber Facebook: https://www.facebook.com/stevegrubershow Instagram: https://www.instagram.com/stevegrubershow/ Twitter: https://twitter.com/Stevegrubershow Rumble: https://rumble.com/user/TheSteveGruberShow

Hope and Help For Fatigue & Chronic Illness
EP83: The Best of 2025: Insights on Chronic Illness Research and Care

Hope and Help For Fatigue & Chronic Illness

Play Episode Listen Later Jan 27, 2026 52:10


Support the Institute today. https://givenow.nova.edu/the-institute-for-neuro-immune-medicine-inim-2025   In this episode, we compile selected highlights from the most impactful podcasts of 2025, featuring insights and clinical perspectives from leading experts, including Dr. Richard C. Deth, Dr. Marc Kesselman, Dr. Nancy Klimas, Dr. Payam Hakimi, and Dr. Philip DeFina. Together, they address critical topics such as ME/CFS, Long COVID, and neuroinflammation. This episode also highlights key themes frequently explored throughout the year, including optimizing metabolic health, the essential role of nutrient-dependent healing, and the impact of environmental toxins and mycotoxins on the body. The experts further share insights into homeopathy, post-traumatic symptoms following neuroinflammation, and the biological and lifestyle factors that help protect brain health. Ultimately, this compilation underscores the importance of communication, trust, and patient-centered relationships in delivering effective care and supporting meaningful healing outcomes. Dr. Richard Deth is a molecular neuroscientist at Nova Southeastern University, where he has worked since 2014 after 38 years at Northeastern University. His research focuses on brain disorders like autism, exploring neurodevelopment, aging, attention, and learning. He studies neurons' metabolic features, particularly the antioxidant glutathione (GSH), its role in methylation, and epigenetic regulation. Dr. Deth investigates how casein and gluten-derived opioid peptides impair cysteine absorption, affecting antioxidant levels and epigenetics. His current work examines oxidative stress, inflammation, and the anti-inflammatory potential of cobinamide, a vitamin B12 precursor. LinkedIn: https://www.linkedin.com/in/richard-deth-2383175/    Dr. Marc Kesselman is the chair and associate professor at the Department of Internal Medicine at Dr. Kiran C. Patel College of Osteopathic Medicine. He is also the chief of the Division of Rheumatology at Nova Southeastern University. Dr. Kesselman received his medical degree from Des Moines University College of Osteopathic Medicine and has been in practice for more than 20 years.  LinkedIn: https://www.linkedin.com/in/marc-m-kesselman-d-o-facoi-facc-facr-6491479/    Dr. Nancy Klimas, a clinical immunologist by training, is the director of the Institute for Neuro-Immune Medicine who has allotted her life to helping other people find cures for their complex illnesses that were once considered helpless. She works with her fellow medical experts in researching and analyzing the deeper causes of such diseases, particularly on the neuro-immunity side, to provide the best option suited for every single case or story they handle.   LinkedIn: https://www.linkedin.com/in/nancy-klimas-49255178/ Instagram: https://instagram.com/nancyklimas     Twitter: https://x.com/ngklimas?s=20      Dr. Payam Hakimi is the Medical Director of Body of Harmony in Beverly Hills, CA, and Miami, FL, offering a range of services including Functional Medicine, Anti-aging Medicine, Hormone Replacement Therapy, Clinical Homeopathy, and IV Nutrition Therapy. A board-certified Doctor of Osteopathic Medicine, Dr. Hakimi blends conventional and complementary medicine with a personalized approach to care. He earned his DO from Western University of Health Sciences, completed his residency at LAC+USC, and served as Chief Resident and Assistant Clinical Professor at USC Keck School of Medicine. A national leader in homeopathic education, Dr. Hakimi is a senior faculty member at the CEDH and the only U.S. physician to consistently lecture on homeopathy at medical conferences, sharing his expertise with diverse healthcare audiences. Instagram: https://www.instagram.com/bodyofharmony/ YouTube: https://www.youtube.com/c/bodyofharmony Instagram: https://www.instagram.com/boironusa/ LinkedIn: https://www.linkedin.com/in/drpayamhakimi/ X: https://x.com/Bodyofharmony   Learn more about the Body of Harmony through their website: https://bodyofharmony.com/   Dr. Philip DeFina has over 40 years of experience as a neuropsychologist and cognitive neuroscientist. He is most known for developing novel, groundbreaking treatment protocols for traumatic brain injury, coma, autism spectrum, and PTSD. He is the founder and Chief Scientific Officer of the International Brain Research Foundation (IBRF). Dr. DeFina previously served on the NYU faculty as an associate professor of neurology and psychiatry at the New York University School of Medicine and the Bellevue Hospital Center. He was a forensic neuropsychologist at the Mount Sinai-Elmhurst Hospital Medical Center and was an adjunct professor at the University of Maryland Psychology Department. Dr. DeFina was also the founder and first director of the Fielding Graduate University's Post-Doctoral Clinical Neuropsychology Training Program. Dr. DeFina subsequently co-founded the school neuropsychology training program at Texas Women's University and co-founded the American Board of School Neuropsychology, and was one of the original founding members of the American Board of Pediatric Neuropsychology.   Website: https://ibrfoundation.org/ Facebook: https://www.facebook.com/people/International-Brain-Research-Foundation/100070365733222/ Instagram: https://www.instagram.com/save.a.soldier/ YouTube: https://www.youtube.com/@IBRFinc   Learn more about the International Institute for Brain Enhancement. Website: https://usbrainenhancement.com/ Instagram: https://www.instagram.com/braininstitute.fl/   Haylie Pomroy, Founder and CEO of The Haylie Pomroy Group, is a leading health strategist specializing in metabolism, weight loss, and integrative wellness. With over 25 years of experience, she has worked with top medical institutions and high-profile clients, developing targeted programs and supplements rooted in the "Food is Medicine" philosophy. Inspired by her own autoimmune journey, she combines expertise in nutrition, biochemistry, and patient advocacy to help others reclaim their health. She is a New York Times bestselling author of The Fast Metabolism Diet.   Learn more about Haylie Pomroy's approach to wellness through her website: https://hayliepomroy.com   Instagram: https://www.instagram.com/hayliepomroy  Facebook: https://www.facebook.com/hayliepomroy  YouTube: https://www.youtube.com/@hayliepomroy/videos  LinkedIn: https://www.linkedin.com/in/hayliepomroy/  X: https://x.com/hayliepomroy     Sign up today for our newsletter. https://nova.us4.list-manage.com/subscribe?u=419072c88a85f355f15ab1257&id=5e03a4de7d    This podcast is brought to you by the Institute for Neuro-Immune Medicine. Learn more about us here.   Website: https://www.nova.edu/nim/ Facebook: https://www.facebook.com/InstituteForNeuroImmuneMedicine Instagram: https://www.instagram.com/NSU_INIM/ Twitter: https://www.twitter.com/NSU_INIM

High Performance Health
Mitochondria, Menopause Energy, and NAD: Why You Feel Flat and How to Fix It | Siobhan Mitchell

High Performance Health

Play Episode Listen Later Jan 26, 2026 58:00


Today I'm joined by neuroscientist and mitochondrial health expert Siobhan Mitchell to cut through the noise around mitochondria, inflammation, NAD, and what actually matters for energy, recovery, and brain health in midlife We unpack why mitochondria are not just “battery packs”, they are a master regulator of oxidative stress, immune signalling, and cellular aging. Siobhan explains the difference between hormetic stress that upgrades your system (like training) versus chronic stress that drains it WHAT YOU'LL LEARN: • What mitochondria actually do, beyond “energy production”  • Mitophagy and mitochondrial biogenesis, and why both decline with age  • The difference between hormetic stress (exercise) and chronic stress (modern life)  • Why mitochondrial dysfunction can drive inflammation and immune overactivation  • How brain energy demand and oestrogen loss intersect in menopause symptoms  • CD38, inflammation, and why staying lean matters for NAD preservation  • Why NAD precursors can be wasted, and what supports conversion inside the cell  • The practical take on timing, training, and recovery support TIMESTAMPS 00:01 Mitochondria, ATP, and the oxidative stress trade-off  04:14 Mitophagy, mitochondrial biogenesis, and aging  16:13 Mitochondria as immune regulators, inflammation and cytokines  23:09 Brain energy, menopause, oestrogen, and cognitive decline mechanisms  29:33 NAD explained, CD38, and why NAD drops with age  48:56 NAD, GLUT4, insulin sensitivity, and perimenopause metabolism  53:19 Where to learn more, discount code, and closing VALUABLE RESOURCES ⁠Join The High Performance Health Community⁠ ⁠Click here⁠ for discounts on all the products I personally use and recommend A BIG thank you to our sponsors who make the show possible Get 10% off MitoQ NAD+ - www.mitoq.com with code ANGELA Get 35% off Timeline Mitopure by visiting this link while the offer lasts - https://www.timeline.com/promotions/angela35 Upgrade your cellular health - get 20% off Beam Minerals at http://beamminerals.com/ANGELA & use code ANGELA at checkout ABOUT THE GUEST Dr Siobhan Mitchell - Chief Scientific Officer - MitoQ Siobhan is the Chief Scientific Officer at MitoQ. She completed her PhD at SUNY Albany and a post-doctoral fellowship in brain ageing at the University of Washington. Siobhan has held roles at the three largest food companies in the world (Unilever, Nestlé, and PepsiCo), where she conducted trials in Europe, North America, and Asia, investigating the effects of nutrition on cognitive decline, mood, and performance. Additionally, she was Senior Director of Research at Noom, where she led a team investigating the behavioural and health effects of weight loss and mental health ABOUT THE HOST Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women's Biohacking Conference, Livestrong & Natural Health Magazine. Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up .without burning out. CONTACT DETAILS ⁠Instagram⁠ ⁠Facebook⁠ ⁠LinkedIn⁠ Disclaimer: The High Performance Health Podcast is for general information purposes only and do not constitute the practice of professional or coaching advice and no client relationship is formed. The use of information on this podcast, or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for medical or other professional advice, diagnosis, or treatment. Users should seek the assistance of their medical doctor or other health care professional for before taking any steps to implement any of the items discussed in this podcast.

🧠 Let's Talk Brain Health!
How Digital Cognitive Assessments Support Brain Health: Real World Insights with Professor Adrian Owen, Ph.D. of Creyos

🧠 Let's Talk Brain Health!

Play Episode Listen Later Jan 21, 2026 38:39


In this episode of the Let's Talk Brain Health! Podcast, we were joined by Professor Adrian Owen, a globally recognized neuroscientist, author, and Chief Scientific Officer of Creyos. The conversation delves into Professor Owen's extensive career in cognitive neuroscience, his groundbreaking research on brain function and dementia, and the innovative digital tools his team has developed to make cognitive assessment more accessible to the public. Key topics include the importance of brain health, the role of sleep in cognitive function, and practical strategies for monitoring and enhancing brain health using technology. Listeners will gain valuable insights on how to take proactive steps to care for their brains and why it's crucial to measure cognitive health accurately and consistently.The episode wraps up with actionable steps listeners can take to prioritize their brain health daily. Join this enlightening conversation to learn more about protecting and optimizing brain function at every stage of life.00:00 Introduction to Let's Talk Brain Health! Podcast00:41 Meet Professor Adrian Owen03:11 Professor Owen's Journey into Neuroscience06:37 Understanding Dementia and Cognitive Decline12:24 The Importance of Brain Health and Cognitive Assessments18:04 The Role of Technology in Brain Health27:06 Future of Neuroscience and Brain Health31:34 Actionable Steps for Better Brain Health37:24 Conclusion and Final ThoughtsResources:Learn more about Creyos' digital cognitive assessments on their website.Explore Creyos' blog for additional resources and information.Stay in touch with Creyos on LinkedIn, Facebook, X, and YouTube. Questions? Email help@creyos.com for additional information.Read more about his book “Into the Gray Zone” and sign up for his next book's release on August 4, 2026, “Think Before You Think: Understanding and Mastering Executive Function.”

Beauty Bytes with Dr. Kay: Secrets of a Plastic Surgeon™
798: Is Your Skincare Aging You? Decoding DNA Methylation & Biological Age with Cristiana Banila

Beauty Bytes with Dr. Kay: Secrets of a Plastic Surgeon™

Play Episode Listen Later Jan 20, 2026 34:26


In this cutting-edge episode of Beauty Bytes, I sit down with Cristiana Banila, the Chief Scientific Officer and co-founder of Mitra Bio, to discuss the revolutionary field of skin epigenetics. We explore the difference between genetics (the hardware) and epigenetics (the operating system) and how non-invasive tape stripping technology allows us to measure biological age and cellular damage without a single biopsy. Cristiana reveals fascinating data on how sun-protected skin is biologically 3.8 years younger than exposed skin, and we tackle a controversial finding from her research: why short-term retinoid use might actually accelerate biological aging by increasing inflammatory markers . We also discuss the future of skin cancer detection and why "resilience" is the new anti-aging standard.

Treating Blood Cancers
Key Insights from Attending ASH 2025

Treating Blood Cancers

Play Episode Listen Later Jan 13, 2026 33:51


Lore Gruenbaum, PhD, Blood Cancer United, Washington, DC Recorded on December 18, 2025 Lore Gruenbaum, PhD Chief Scientific Officer & Senior Vice President of Research Blood Cancer United Washington, DC Join Dr. Lore Gruenbaum, Chief Scientific Officer and Senior Vice President of Research at Blood Cancer United, to provide practice-changing data in hematologic malignancies from the 67th American Society of Hematology (ASH) Annual Meeting. Explored are breakthroughs in multiple myeloma, AML, CLL, and advances in cell therapy. Discussion also covers the growing use of artificial intelligence to accelerate precision medicine, spotlighting the Blood Cancer United Beat AML® Master Clinical Trial as a model for AI-driven trial design and real-time clinical decision-making. Tune in today for the key takeaways you need to know! Additional Blood Cancer United Resources: Blood Cancer United Accredited and Non-Accredited Healthcare Professional Education Blood Cancer United Resources for Patients

Ask Dr. Drew
Dr. Peter McCullough: New Boss Of ACIP Vaccine Committee Was FIRED By Practice For Supporting RFK & Questioning COVID Response w/ Dr. Kirk Milhoan & Jeffrey A. Tucker – Ask Dr. Drew – Ep 575

Ask Dr. Drew

Play Episode Listen Later Jan 11, 2026 89:46


After decades of saving lives, retired Air Force Colonel Dr. Kirk Milhoan was fired from his pediatric cardiology practice after being named chair of the CDC's Advisory Committee on Immunization Practices (ACIP). The dismissal followed social media pressure protesting his support of HHS Secretary Robert F Kennedy Jr. and his questioning of many childhood vaccine policies. Dr. Milhoan was only reinstated after significant public backlash. His wife, anesthesiologist Dr. Kim Milhoan, wrote “The irony is they are trying to destroy the career of someone who was on their side, but willing to re-examine the evidence.” Dr. Peter McCullough is a cardiologist, internist, and epidemiologist, serving as Chief Scientific Officer of The Wellness Company. He co-authored “Vaccines: Mythology, Ideology, and Reality” and “The Courage to Face COVID-19.” Follow at https://x.com/P_McCulloughMD Dr. Kirk Milhoan is a pediatric cardiologist and Chair of the CDC's Advisory Committee on Immunization Practices. He was fired by his cardiology office – and later reinstated after public backlash – following his appointment to lead ACIP. Follow at https://x.com/KMilhoanMDPhD Jeffrey Tucker is Founder and President of the Brownstone Institute. He is also Senior Economics Columnist for Epoch Times, author of 10 books, including Liberty or Lockdown. Follow him at https://x.com/jeffreyatucker and https://brownstone.org/ 「 SUPPORT OUR SPONSORS 」 • AUGUSTA PRECIOUS METALS – Thousands of Americans are moving portions of their retirement into physical gold & silver. Learn more in this 3-minute report from our friends at Augusta Precious Metals: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drdrew.com/gold⁠⁠⁠⁠⁠⁠⁠⁠⁠ or text DREW to 35052 ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠• FATTY15 – The future of essential fatty acids is here! Strengthen your cells against age-related breakdown with Fatty15. Get 15% off a 90-day Starter Kit Subscription at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drdrew.com/fatty15⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ • PALEOVALLEY - "Paleovalley has a wide variety of extraordinary products that are both healthful and delicious,” says Dr. Drew. "I am a huge fan of this brand and know you'll love it too!” Get 15% off your first order at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://drdrew.com/paleovalley⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ • VSHREDMD – Formulated by Dr. Drew: The Science of Cellular Health + World-Class Training Programs, Premium Content, and 1-1 Training with Certified V Shred Coaches! More at https://drdrew.com/vshredmd • THE WELLNESS COMPANY - Counteract harmful spike proteins with TWC's Signature Series Spike Support Formula containing nattokinase and selenium. Learn more about TWC's supplements at ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://twc.health/drew⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ 「 ABOUT THE SHOW 」 Ask Dr. Drew is produced by Kaleb Nation (⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://kalebnation.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠) and Susan Pinsky (⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://twitter.com/firstladyoflov⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠e⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠). This show is for entertainment and/or informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment. Executive Producers • Kaleb Nation - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://kalebnation.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ • Susan Pinsky - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://x.com/firstladyoflove⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Content Producer & Booking • Emily Barsh - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://x.com/emilytvproducer⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Hosted By • Dr. Drew Pinsky - ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://x.com/drdrew⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

Empowered Patient Podcast
Reality Check from Biotech Leaders on Using AI in Drug Discovery with BioXcel Therapeutics Gain Therapeutics iBio

Empowered Patient Podcast

Play Episode Listen Later Jan 7, 2026 47:29


This roundtable on the role of AI in the biotech sector features Frank Yocca, Senior VP and Chief Scientific Officer at BioXcel Therapeutics, Joanne Taylor, Senior VP for Research at Gain Therapeutics, and Martin Brenner, CEO and Chief Scientific Officer at iBio. The conversation covers the historical adoption of AI in biotech, its current use in drug discovery, and future possibilities.  AI is not a new phenomenon in biotech and has evolved from data processing to sophisticated models that can screen vast amounts of data. There is a critical need for high-quality, structured data to train effective AI models, and these experts caution about the hype surrounding AI-generated discoveries and emphasize the need for real-world biological and human testing. Frank explains, "We are all about AI right from the get-go. We sort of inherited that from the parent company, BioXcel, which is now BioXcel, LLC. The company started by deploying data science on big biomedical and other datasets. Much of the data was unstructured and required significant curation, which at first was largely manual. Later, we began deploying more natural language processing and knowledge graphs to predict whether drugs that initially failed but were safe could be repurposed for other indications. More recently, the latest evolution has really been to use large language models and more agentic workflows to generate hypotheses and insights."   Joanne explains, "So Gain has had for many years, I think 10 years also, a virtual drug discovery platform where we've been able to screen millions of compounds virtually to discover allosteric binding molecules. But about three or so years ago, we made the change from screening millions of compounds to screening, now we're up to the capability of screening trillions of compounds." "We can screen in days, whereas it would take you months and maybe a year to do high-throughput screening. But in terms of having introduced AI into this system, it means that we can do things better because obviously, if you can screen trillions of compounds, you're screening more of the possibilities, you are going to be making better drugs. At least that's the hypothesis than if you are screening fewer compounds. So it's the fact that this is a fast tool set that makes you able to do things that you wouldn't have been otherwise able to do, but it doesn't necessarily make the process itself that much faster because you are doing much more." Martin elaborates, "So we had the good fortune to start from scratch. We're a very small company. We have made from the get-go the decision that our scientists would be bilingual. They're not only data and AI scientists, but they're also biologists. That makes it a lot easier to translate between the two disciplines. We literally started, or Rubrik Therapeutics started, on the hypothesis that would be a model of structure prediction for proteins. So the company was clearly ahead of its time, and we started by making molecules that set up better than existing ones. And that's, I think, a very low hurdle that a lot of people are doing right now. And you hear sometimes this overreaching argument, we make AI drugs. First of all, tomorrow medicines take 10,000 steps, and enabling three of them is not making an AI drug, but making better molecules. This was the first important step." #BioXcel #GainTherapeutics #iBio #AI #ClinicalAI #ArtificialIntelligence #Biotechnology #DrugDiscovery #PersonalizedMedicine #HealthcareInnovation #BiopharmaAI #ClinicalTrials #RareDisease #Neuroscience #PrecisionMedicine #HealthTech #BiotechLeadership #AIinHealthcare #DrugDevelopment #MedicalInnovation bioxceltherapeutics.com  gaintherapeutics.com  ibioinc.com Download the transcript here    

Empowered Patient Podcast
Reality Check from Biotech Leaders on Using AI in Drug Discovery with BioXcel Therapeutics Gain Therapeutics iBio TRANSCRIPT

Empowered Patient Podcast

Play Episode Listen Later Jan 7, 2026


This roundtable on the role of AI in the biotech sector features Frank Yocca, Senior VP and Chief Scientific Officer at BioXcel Therapeutics, Joanne Taylor, Senior VP for Research at Gain Therapeutics, and Martin Brenner, CEO and Chief Scientific Officer at iBio. The conversation covers the historical adoption of AI in biotech, its current use in drug discovery, and future possibilities.  AI is not a new phenomenon in biotech and has evolved from data processing to sophisticated models that can screen vast amounts of data. There is a critical need for high-quality, structured data to train effective AI models, and these experts caution about the hype surrounding AI-generated discoveries and emphasize the need for real-world biological and human testing. Frank explains, "We are all about AI right from the get-go. We sort of inherited that from the parent company, BioXcel, which is now BioXcel, LLC. The company started by deploying data science on big biomedical and other datasets. Much of the data was unstructured and required significant curation, which at first was largely manual. Later, we began deploying more natural language processing and knowledge graphs to predict whether drugs that initially failed but were safe could be repurposed for other indications. More recently, the latest evolution has really been to use large language models and more agentic workflows to generate hypotheses and insights."   Joanne explains, "So Gain has had for many years, I think 10 years also, a virtual drug discovery platform where we've been able to screen millions of compounds virtually to discover allosteric binding molecules. But about three or so years ago, we made the change from screening millions of compounds to screening, now we're up to the capability of screening trillions of compounds." "We can screen in days, whereas it would take you months and maybe a year to do high-throughput screening. But in terms of having introduced AI into this system, it means that we can do things better because obviously, if you can screen trillions of compounds, you're screening more of the possibilities, you are going to be making better drugs. At least that's the hypothesis than if you are screening fewer compounds. So it's the fact that this is a fast tool set that makes you able to do things that you wouldn't have been otherwise able to do, but it doesn't necessarily make the process itself that much faster because you are doing much more." Martin elaborates, "So we had the good fortune to start from scratch. We're a very small company. We have made from the get-go the decision that our scientists would be bilingual. They're not only data and AI scientists, but they're also biologists. That makes it a lot easier to translate between the two disciplines. We literally started, or Rubrik Therapeutics started, on the hypothesis that would be a model of structure prediction for proteins. So the company was clearly ahead of its time, and we started by making molecules that set up better than existing ones. And that's, I think, a very low hurdle that a lot of people are doing right now. And you hear sometimes this overreaching argument: we make AI drugs. First of all, tomorrow medicines take 10,000 steps, and enabling three of them is not making an AI drug, but making better molecules. This was the first important step." #BioXcel #GainTherapeutics #iBio #AI #ClinicalAI #ArtificialIntelligence #Biotechnology #DrugDiscovery #PersonalizedMedicine #HealthcareInnovation #BiopharmaAI #ClinicalTrials #RareDisease #Neuroscience #PrecisionMedicine #HealthTech #BiotechLeadership #AIinHealthcare #DrugDevelopment #MedicalInnovation bioxceltherapeutics.com  gaintherapeutics.com  ibioinc.com Listen to the podcast here    

Data in Biotech
From discovery to delivery: AI's impact on nanomedicine

Data in Biotech

Play Episode Listen Later Dec 31, 2025 46:31


In this episode of Data in Biotech, Ross Katz chats with Mitra Mosharraf, Chief Scientific Officer at HTD Biosystems, about how AI and machine learning are revolutionizing nanomedicine. They explore the use of AI in drug discovery, formulation, manufacturing, and clinical development, highlighting how data-driven strategies are improving safety, reducing costs, and enabling more personalized therapies in the biotech space. What you'll learn in this episode: >> How AI and ML reduce costs and increase success rates in nanomedicine development. >> Key challenges in nano drug delivery and how machine learning helps overcome them. >> How HTD Biosystems' iFormulate platform speeds up formulation with predictive modeling. >> How wearables and real-time data are reshaping clinical trial design. >> The future of personalized and automated drug delivery systems. Meet our guest Mitra Mosharraf is the Chief Scientific Officer at HTD Biosystems and co-founder of Engimata Inc. With 20+ years of experience, she leads innovation in biologics, nanomedicine, and lipid-based delivery systems. Mitra is a recognized thought leader in pharmaceutical sciences. About the host Ross Katz is Principal and Data Science Lead at CorrDyn. Ross specializes in building intelligent data systems that empower biotech and healthcare organizations to extract insights and drive innovation. Connect with Our Guest: Sponsor: CorrDyn, a data consultancyConnect with Mitra Mosharraf on LinkedIn  Connect with Us: Follow the podcast for more insightful discussions on the latest in biotech and data science.Subscribe and leave a review if you enjoyed this episode!Connect with Ross Katz on LinkedIn Sponsored by… This episode is brought to you by CorrDyn, the leader in data-driven solutions for biotech and healthcare. Discover how CorrDyn is helping organizations turn data into breakthroughs at CorrDyn.

Find your model health!
#409 PT2; Causes Of Kidney Disease, The Thyroid Connection, Alcohol & Gout with Stephen McConnell MSc.

Find your model health!

Play Episode Listen Later Dec 29, 2025 47:11


In this powerful follow-up conversation, I sit down again with Stephen McConnell Msc to unpack the real causes of kidney disease, why the thyroid is deeply involved, and how lifestyle factors like alcohol and uric acid quietly drive damage long before symptoms appear. This is the perfect continuation to help fill in any gaps from our first conversation (go listen if you haven't already). This episode is essential listening if you or someone you love has kidney issues, gout, thyroid dysfunction, or unexplained metabolic symptoms. In this episode, we discuss: • How kidney disease should really be diagnosed • The different stages of kidney disease and what they mean • Why African-Americans experience kidney disease at much higher rates • Foamy or bubbly urine as a sign of protein loss and kidney stress • The critical thyroid–kidney connection that is very much overlooked • Why up to 90% of stage 4 kidney disease patients are hypothyroid • How niacin supports deiodinase activity and T4 → T3 conversion • How modern lifestyle habits increase acidity and damage kidney tissue • Alcohol as a metabolic and renal toxin ☠️ • Natural strategies for lowering uric acid and improving gout, including methylfolate, colchicine seeds and tart cherry extract This conversation connects dots most people and many practitioners never look at. We think you will enjoy this, let us know in the comments. Stephen D. McConnell, MSc, is a lipid specialist and Chief Scientific Officer at Health Defender, a physician-recommended nutraceutical company based in Erie, Pennsylvania. With extensive clinical experience developing successful lipid clinics and leading a landmark outcomes partnership with Highmark/Blue Cross-Blue Shield, he focuses on evidence-based, natural approaches to cholesterol management and cardiovascular health. Stephen McConnell is a recognized voice in functional and integrative lipid care. Connect with Stephen here; LinkedIn - / stephen-d-mcconnell-msc-lipidemiologist Website - https://healthdefender.care/ YouTube - ‪@HealthDefender-USA‬ Phone (it is better to send a text) - 8145721801

HealthcareNOW Radio - Insights and Discussion on Healthcare, Healthcare Information Technology and More
Health UnaBASHEd: Risk, Resilience, and the Future of Medicine with Michael Rosenblatt, MD

HealthcareNOW Radio - Insights and Discussion on Healthcare, Healthcare Information Technology and More

Play Episode Listen Later Dec 13, 2025 28:16


On this episode Gil sits with Michael Rosenblatt, MD, one of the most accomplished physician-scientists in modern medicine. He is former Chief Medical Officer of Merck, where he led global scientific strategy and medical affairs. Previously he served as Dean of Tufts University School of Medicine, Chief Scientific Officer at Vertex Pharmaceuticals, and Professor of Medicine at Harvard Medical School, where he advanced groundbreaking research in endocrinology, metabolic bone disease, and translational science. We discuss the intersection of academia, biotechnology, pharmaceutical innovation, and the clinical science shaping modern drug development and the future of precision therapeutics.

Find your model health!
#407 PT1; Kidney Disease, Niacin, Hypertension & Diabetes with Stephen McConnell MSc.

Find your model health!

Play Episode Listen Later Dec 13, 2025 91:09


In Part 1 of this two-part series, Steven McConnell MSc, lipidemiologist, reveals what conventional medicine often misses in diagnosing and treating kidney disease. Stephen is passionate and outspoken when it comes to patient care. We think you will really enjoy this conversation - you may need to listen to it twice. ;) In this episode, we cover: Why 75% of people with kidney disease have hypothyroidism! The key tests you should look at to understand your kidney health How niacin can support kidney function and influence many health and gene pathways Herbal remedies and supplements that may help protect or improve kidney health The main causes of kidney disease and why monitoring blood pressure and blood sugar is critical Overlooked considerations around kidney health by conventional medicine Can kidney disease be reversed, and actionable insights for prevention and support And lots more. Whether you're a health professional or someone who wants to take control of your kidney and metabolic health, this episode is packed with evidence-based insights and practical advice. Watch out for Part 2 coming soon! Stephen D. McConnell, MSc, is a lipid specialist and Chief Scientific Officer at Health Defender, a physician-recommended nutraceutical company based in Erie, Pennsylvania. With extensive clinical experience developing successful lipid clinics and leading a landmark outcomes partnership with Highmark/Blue Cross-Blue Shield, he focuses on evidence-based, natural approaches to cholesterol management and cardiovascular health. Stephen McConnell is a recognized voice in functional and integrative lipid care. Connect with Stephen here; LinkedIn - / stephen-d-mcconnell-msc-lipidemiologist Website - https://healthdefender.care/ YouTube - ‪@HealthDefender-USA‬ Phone (it is better to send a text) - 8145721801

Jerm Warfare: The Battle Of Ideas
Mike Yeadon regrets being a Pfizer executive

Jerm Warfare: The Battle Of Ideas

Play Episode Listen Later Dec 9, 2025 68:53


This episode was recorded for my UK Column show.Mike Yeadon is a former Vice President and Chief Scientific Officer for allergy and respiratory research at Pfizer, where he spent 16 years developing new medicines before founding his own biotech company, Ziarco.With a PhD in pharmacology and over 30 years in pharmaceutical research, Mike became one of the most prominent voices challenging the official Covid narrative. He was amongst the first credentialed scientists to call out the government's 'lethally incompetent' scientific advice, arguing that lockdowns were based on flawed PCR testing that produced massive numbers of false positives.Mike consistently warned that the so-called 'second wave' was fabricated through dodgy testing protocols, pointing out that respiratory deaths in late 2020 were actually lower than in previous years. His outspoken criticism of the experimental Covid injections—which he argued were 'toxic by design' and failed to prevent illness or transmission—led to widespread censorship across social media platforms.➡️ Mike's Substack

Technology of Beauty
Ep. 202 - Michael Heke on Harnessing Age Zero Exosomes for Powerful Skin Renewal

Technology of Beauty

Play Episode Listen Later Dec 9, 2025 41:59


In this episode of The Technology of Beauty, Dr. Grant Stevens welcomes Dr. Michael Heke, Chief Scientific Officer and Managing Director at Resiliélle, for a cutting-edge conversation about the next frontier in aesthetic innovation: Age Zero exosomes. With a background in regenerative medicine and decades of research in stem cell biology, Dr. Heke explains why these exosomes, harvested from Wharton's jelly of the umbilical cord, may represent the most potent tool available for skin healing, repair, and rejuvenation.Together, they unpack the science behind “Age Zero” — a term that reflects the extraordinary regenerative power of perinatal stem cells, whose exosomes are rich in growth factors, cytokines, and genetic instructions for renewal. Unlike freeze-dried alternatives or platelet-based products, Resiliélle's clinical-grade exosomes are frozen fresh and meticulously validated for purity, potency, and performance.Dr. Heke also shares real-world applications in aesthetics, including accelerated healing after microneedling, improvements in scar remodeling, and visible enhancements in hair growth and skin texture. If you've been curious about exosomes, and what makes one product more effective than another, this episode delivers clarity from a true scientific authority.» Apple Podcasts | https://podcasts.apple.com/us/podcast/technology-of-beauty/id1510898426» Spotify | https://open.spotify.com/show/0hEIiwccpZUUHuMhlyCOAm» Recent episodes | https://www.influxmarketing.com/technology-of-beauty/» Instagram | https://www.instagram.com/thetechnologyofbeauty/» LinkedIn | https://www.linkedin.com/company/the-technology-of-beauty/The Technology of Beauty is produced by Influx Marketing, The Digital Agency for Aesthetic Practices. https://www.influxmarketing.com/Want more aesthetic insights? Subscribe to Next Level Practices, the show where we discuss the ever-changing world of digital marketing and patient acquisition and bring you the latest ideas, strategies, and tactics to help you take your practice to the next level. https://www.influxmarketing.com/next-level-practices/

Good Life Project
Hope, Not Fear: New Conversations on Cancer Breakthroughs | Future of Medicine [Ep. 6]

Good Life Project

Play Episode Listen Later Dec 8, 2025 54:12


From breakthrough AI diagnostics to personalized immunotherapy treatments, cancer care is undergoing a revolution that's already saving lives.Dr. Ross Levine, Chief Scientific Officer at Memorial Sloan Kettering, shares how new technologies are helping doctors detect cancer earlier, treat it more effectively, and transform what was once untreatable into manageable conditions. Whether you're navigating cancer personally or professionally, this conversation offers crucial insights into the future of medicine and why there's unprecedented hope in cancer treatment today.You can find Ross at: Website | Episode TranscriptIf you LOVED this episode, don't miss a single conversation in our Future of Medicine series, airing every Monday through December. Follow Good Life Project wherever you listen to podcasts to catch them all.Check out our offerings & partners: Join My New Writing Project: Awake at the WheelVisit Our Sponsor Page For Great Resources & Discount Codes Hosted on Acast. See acast.com/privacy for more information.

The Steve Gruber Show
Dr. Peter McCullough | Flu, COVID, RSV, and Bird Flu: How to Protect Yourself This Holiday Season

The Steve Gruber Show

Play Episode Listen Later Dec 1, 2025 8:30


Steve Gruber sits down with Dr. Peter McCullough, Chief Scientific Officer at The Wellness Company, to get a clear-eyed look at this year's flu, COVID-19, RSV, and even the Bird Flu (H5N5). They discuss how to keep your immune system strong, what to expect from the more virulent flu strains, and which prescription drugs you should have on hand to avoid the ER this holiday season. Don't miss Cyber Monday Savings! 25% off Supplements & RX including Ivermectin! 20% off memberships & medical kits! Free whipped tallow cream for first 1000 orders! Visit TWC.Health/Gruber

Inside Reproductive Health Podcast
272 The Massive Blindspot in IVF Costing. Dr. Jason Barritt. Steve Rooks.

Inside Reproductive Health Podcast

Play Episode Listen Later Nov 30, 2025 59:26


How much does an IVF cycle cost?Seems like a simple question. But as this week's guests explain, it's not.The way most of us account for “an IVF cycle” hides how many individual work orders and variables are actually involved. That lack of clarity can distort cost, efficiency, and strategy.This week on Inside Reproductive Health, Griffin talks with Steve Rooks, co-author of a groundbreaking paper in JARG on activity-based costing in IVF, and Dr. Jason Barritt, Chief Scientific Officer at Kindbody, to unpack what's really behind those numbers.Together, they discuss:– Why “an IVF cycle” isn't a single service but a set of unique work orders– How retrieval volume, ICSI, and PGT each reshape the cost per cycle– The dramatic efficiency differences between labs performing 200 vs. 4,000 cycles per year– The growing impact of managed care on margins– How scalable systems like AURA from Conceivable Life Sciences could expand IVF access

Oh, My Health...There Is Hope!
Discover the Power of Algae for Optimal Health and Wellness with Catharine Arnston

Oh, My Health...There Is Hope!

Play Episode Listen Later Nov 26, 2025 29:41


  "It doesn't have to be complicated to be healthy." -Catharine Arntson Catharine Arnston is the founder, CEO, and Chief Scientific Officer of Energy Bits, a pioneering company in the algae nutrition market. Highlighting a notable journey from corporate life to health entrepreneurship, Catharine embarked on a research mission into plant-based nutrition after her sister's breast cancer diagnosis. This pursuit led her to discover algae's superfood qualities, widely embraced in Asia but underrecognized in the US. With over 300 appearances on podcasts and TV shows, Catharine is a passionate advocate for algae, emphasizing its health benefits and potential as the ultimate nutritional solution. Episode Summary: Join host Jana Short as she welcomes Catharine Arnston back to the podcast, where they dive into the fascinating world of algae nutrition. In this episode, Catharine shares her personal journey and the pivotal moments that led her to discover the profound health benefits of algae. As the founder of Energy Bits, she explains how this nutrient-dense superfood can play an essential role in everyday wellness. Highlighting algae's origins, its transformative impact on her life, and the profound science-backed reasons it should be a staple in health-conscious diets, Catharine reveals how algae tablets can fit seamlessly into any lifestyle. Catharine discusses the critical differences between spirulina and chlorella algae, unraveling the unique properties that support various aspects of physical and mental health. Spirulina's astonishing capacity to boost energy and focus with its mitochondrial support and nutrient richness makes it invaluable for daily use, while chlorella is celebrated for its detoxifying benefits and nighttime wellness support. Catharine also emphasizes the significance of transparent production practices and traceable quality, providing a comprehensive insight into why algae belongs in the nutritional routine of everyone, from children to adults and even pets. Aspiring to spark a wellness revolution, Catharine and Jana explore the vast potential algae holds for improved health and vitality. Key Takeaways: Origins and Discovery of Algae: Algae is one of the oldest forms of life on Earth, offering unparalleled nutritional benefits. Catharine's journey began with her sister's cancer diagnosis, leading to a deep dive into algae's potential. Spirulina vs. Chlorella: Spirulina is termed as 'nutritional insurance' due to its energy-enhancing and nutrient-dense properties, while chlorella is regarded as 'health insurance' due to its detoxifying abilities and role in recovery. Health Benefits for All Ages and Pets: Algae is safe for children and pets, easily integrates into any diet, and even supports special dietary needs, emphasizing its universal health benefits. Simplifying Health with Algae: Algae tablets can replace multiple supplements, simplifying wellness routines while delivering comprehensive nutritional benefits. A Vision for the Future: With extensive scientific backing, Catharine envisions algae transforming global health landscapes by promoting more informed and accessible wellness choices.   Resources: https://www.instagram.com/catharinearnston/?hl=en https://www.linkedin.com/in/catharinearnston   Use Coupon Code:** JanaShort for 20% OFF**     ✨ Enjoying the show? Stay inspired long after the episode ends! Jana is gifting you free subscriptions to Ageless Living Magazine and Best Holistic Life Magazine—two of the fastest-growing publications dedicated to holistic health, personal growth, and living your most vibrant life. Inside, you'll find powerful stories, expert insights, and practical tools to help you thrive—mind, body, and soul.  

Unwritten Beauty Talks
Inside Factor Five Skincare Human Stem Cells : Dr. Dave Stachura & Tiffany Underwood on Growth Factors, Exosomes & Effective Skincare

Unwritten Beauty Talks

Play Episode Listen Later Nov 19, 2025 48:41


Send us a textIn this episode of Unwritten Beauty Talks, host Katarina Forster sits down with Dr. Dave Stachura and Tiffany Underwood from Factor Five Skincare to explore the science behind growth factors, stem cells, exosomes, and clean beauty.They discuss Factor Five's mission to create effective, clean skincare products without fillers or unnecessary additives, the science behind their formulations, and how their products address a wide range of skin concerns. The conversation also delves into how skincare treatments promote healing, collagen production, and client confidence, while highlighting the differences between stem cells, growth factors, and exosomes.Factor Five Skincare focuses on growth factors and stem cells to deliver effective skincare solutions.Their mission is to provide clean, additive-free products without compromising results.Understanding the differences between stem cells, growth factors, and exosomes is key for informed skincare decisions.Skincare treatments often involve controlled disruptions to promote healing, collagen production, and skin renewal.Factor Five products are designed for a wide range of skin types and concerns, including sensitive skin.Their eye and lash cream is highly effective and safe for daily use.Retinol can be safely included in skincare for sensitive skin when formulated correctly.Exosomes need to be stabilized for effective use in topical skincare products.Dr. Dave Stachura – Chief Operations Officer and Chief Scientific Officer at Factor Five Skincare and SpecBio, Dr. Stachura leads the science behind all Factor Five formulations. He holds a BSc in Molecular Biology from Lehigh University and a PhD in Cellular and Molecular Biology from the University of Pennsylvania, followed by postdoctoral training at UC San Diego. His career focuses on genetic control of adult stem cell biology using hematopoietic stem cells (HSCs) and adipose-derived mesenchymal stem cells (ADMSCs). Dr. Stachura has several patents, published over 40 peer-reviewed articles, contributed two book chapters, and edited an immunology textbook. He continues research in stem cells, immunology, exosomes, skincare, and wound healing and founded Philanthropic Pharma, a nonprofit pharmaceutical company aimed at discovering new treatments for human diseases.Tiffany Underwood – Director of Education at Factor Five Skincare, Tiffany works closely with professional partners and brings a strong clinical perspective to the team. A licensed esthetician and founder of SkinCo, she blends biology, product formulation, and advanced esthetics to deliver results-driven treatments while empowering professionals to stay connected to their “why.” Inspired by her journey with cancer.

Smart Biotech Scientist | Bioprocess CMC Development, Biologics Manufacturing & Scale-up for Busy Scientists
207: Cryogenic Infrared Ion Spectroscopy: From Mass Spec Limitations to Molecular Precision with Tom Rizzo - Part 1

Smart Biotech Scientist | Bioprocess CMC Development, Biologics Manufacturing & Scale-up for Busy Scientists

Play Episode Listen Later Nov 18, 2025 22:35


What if you could identify every structural variant in your biologics—without ambiguity, without massive sample requirements, and without the guesswork that plagues traditional mass spectrometry? Cryogenic infrared ion spectroscopy (CIRIS) makes it possible, transforming molecular characterization from frustrating puzzle to precise science.Today's guest, Professor Tom Rizzo, bridges the gap between academic innovation and industrial application. As former Dean of the School of Basic Sciences at EPFL in Lausanne and now Chief Scientific Officer at Isospec Analytics, Tom has spent over two decades developing analytical techniques that solve problems conventional methods can't touch.His journey from a childhood fascination sparked by chemistry demonstrations at the 1964 New York World's Fair to pioneering a breakthrough technology reveals both the persistence required for true innovation and the pathway from laboratory curiosity to commercial reality. For bioprocess scientists struggling with glycan characterization, isomer identification, or any structural puzzle where mass spec alone falls short, this conversation offers both validation and solutions.Episode Highlights:The fundamental limitations of current biomolecular analysis methods and why innovation is critical (02:51)From World's Fair chemistry demos to laser spectroscopy: Tom Rizzo's path to analytical innovation (03:31)The two-decade quest to combine mass spectrometry sensitivity with laser spectroscopy precision—and the machine that finally made it work (04:26)Why Tom transitioned from academic leadership to Isospec Analytics: bringing lab techniques to production environments (09:17)CIRIS fundamentals: how cooling ions to 10 Kelvin unlocks molecular fingerprints that room-temperature methods miss (11:14)CIRIS advantages for biologics: single-ion sensitivity, isomer discrimination, and unique molecular "fingerprints" for definitive identification (14:25)Integrating CIRIS into existing bioprocess workflows: LC-MS compatibility and the path to commercial instrumentation (17:29)Hard-won lessons from translating academic breakthroughs into industrial tools (17:43)When mass spectrometry hits its limits—distinguishing isomers, characterizing glycans, identifying unknowns in complex mixtures—cryogenic infrared ion spectroscopy provides the structural resolution you need. This isn't incremental improvement; it's a fundamental expansion of what's analytically possible.If you're facing molecular identification challenges that conventional methods can't solve, or if you're curious how next-generation analytical techniques will transform bioprocess development, this episode delivers actionable insights from a scientist who's lived both the innovation and implementation journey.Connect with Tom Rizzo:LinkedIn: www.linkedin.com/in/thomas-rizzo-4a0a6314/Contact email: tom@isospec.chIsospec Analytics website: www.isospecanalytics.comNext step:Book a 20-minute call to help you get started on any questions you may have about bioprocessing analytics: https://bruehlmann-consulting.com/call

Essentially You: Empowering You On Your Health & Wellness Journey With Safe, Natural & Effective Solutions
693: Tired All the Time? It Might Be Hidden Problems With Your Mitochondria with Siobhan Mitchell

Essentially You: Empowering You On Your Health & Wellness Journey With Safe, Natural & Effective Solutions

Play Episode Listen Later Nov 11, 2025 50:31


Ready to boost your energy and future-proof your health? In this episode, I'm joined by expert neuroscientist Dr. Siobhan Mitchell, who breaks down why your mitochondria—the tiny powerhouses inside your cells—are the secret to healthy aging.  She explains how the perimenopause and menopause transition is not just hormonal, but a neuroendocrine shift that impacts your brain, mood, energy, AND vitality.  And even if you're doing your best to bring on lifestyle recommendations for optimizing mitochondrial health, odds are you still need more support than just that in midlife. So, that's where the supplement MitoQ comes into play.  As MitoQ's Chief Scientific Officer, Dr. Mitchell reveals how this advanced antioxidant works deep inside your cells to enhance mitochondrial function, boosting mental clarity and long-term longevity.  Tune in and discover how to fuel your energy, elevate your mood, and embrace midlife feeling stronger than ever! Dr. Siobhan Mitchell  Siobhan Mitchell is the chief scientific officer of MitoQ. She completed her PhD at SUNY Albany and a post-doctoral fellowship on brain aging at the University of Washington. Siobhan has held roles at the three largest food companies in the world (Unilever, Nestle, and Pepsico), leading trials worldwide, which researched the effects of nutrition on cognitive decline, mood, and performance. She was also senior director at Noom, where she directed a team investigating chronic disease management, weight loss, and mental health digital programs using cognitive behavior therapy methods. IN THIS EPISODE Why mitochondria are a key contributing factor to aging  Preventing menopause symptoms in relation to brain changes  Research on estrogen levels in menopause for longevity  Lifestyle changes for enhanced cognitive functioning  The impact stress has on your mitochondrial function  How to notice if your mitochondria aren't working well  How MitoQ supplementation boosts cell vitality and longevity  Ways to measure your mitochondrial function  QUOTES“You get these overactive mitochondria that are also producing energy and oxidative stress at much higher levels, and these oxidative stress mechanisms can also bring on faster aging through inflammation and things like that.” “[MitoQ] is basically helping protect your mitochondria from excessive oxidative stress. It gets into the mitochondria better than any other supplement on the market because it was especially engineered to have this tag that allows it to get into the mitochondria up to [about] 90%.” RESOURCES MENTIONED Order my new book: The Perimenopause Revolution https://drmariza.com/book Use code DRMARIZA and get 15% off your order of Silverbiotics https://silverbiotics.com/discount/drmariza Use code: ENERGIZED for 10% off your order of MitoQ HERE! http://mitoq.com MitoQ on Instagram Siobhan on X  RELATED EPISODES  #688: Unlock Cellular Energy and Longevity with Urolithin A + Mitochondrial Optimization with  Jen Scheinman  #653: Mitochondria, Menopause & Metabolism: The Cellular Secret to More Energy After 40 with Dr. Felice Gersh #663: From Wired and Tired to Calm and Energized: The GABA-Mitochondria Connection + How to Fix It at the Cellular Level with Dr. Scott Sherr #623: Red Light Therapy for Upgrading Your Mitochondria, Cellular Energy, Skin and Brain Health with Jonathan Otto #690: The Perimenopause Revolution: Why midlife isn't the end — it's the beginning of your most energized, powerful, and vibrant self

Resiliency Radio
286: Resiliency Radio with Dr. Jill: Targeting Mitochondria for Healthy Aging and Resilience

Resiliency Radio

Play Episode Listen Later Nov 10, 2025 45:57


In this science-backed and empowering episode of Resiliency Radio, Dr. Jill Carnahan is joined by Dr. Siobhan Mitchell, Chief Scientific Officer of MitoQ, to explore how optimizing mitochondrial health can revolutionize the way we age, perform, and heal. ⚡ Together, they unpack the critical role mitochondria play in everything from immune function and brain health to energy production, resilience, and mental well-being. Discover how MitoQ, a breakthrough antioxidant supplement, supports mitochondrial function, enhances athletic performance, and may even aid mental health and PTSD recovery by repairing cellular damage and reducing inflammation.

TechNation Radio Podcast
Episode 649: Episode 25-43 You Are Smarter Than You Think !!!

TechNation Radio Podcast

Play Episode Listen Later Nov 6, 2025 59:00


On this week's Tech Nation, Moira speaks withYou are smarter than you know - Dr. Angus Fletcher talks about Primal Intelligence, and then Dr. Derek Jantz from Tune Therapeutics explains how they aim to "tune" DNA - not just with human DNA, but stopping the Hepatitis B virus in its tracks.BTN Title: Tuning DNA, and Tuning Out Hepatitis BDr Derek Jantz, the Chief Scientific Officer of Tune Therapeutics, explains their approach, now in advanced clinical trials for Hepatitis B.

Smart Biotech Scientist | Bioprocess CMC Development, Biologics Manufacturing & Scale-up for Busy Scientists
204: Mastering CRO Selection: Essential Questions for CMC Analytical Development with Daniel Galbraith - Part 2

Smart Biotech Scientist | Bioprocess CMC Development, Biologics Manufacturing & Scale-up for Busy Scientists

Play Episode Listen Later Nov 6, 2025 20:13


Cell and gene therapies are transforming modern medicine, but their path to market is fast and complex. They often jump from small trials to global launch at record speed, putting pressure on analytics, supply chains, and partnerships. Success depends on making smart choices about what to build in-house and what to entrust to expert partners.Daniel Galbraith knows these challenges intimately. With decades of hands-on experience and as Chief Scientific Officer at Solvias, Daniel has witnessed firsthand the seismic shifts in analytical development for advanced therapies. He's been on every side of the table: troubleshooting manufacturing snags, scaling up from a single batch to hundreds per month, and guiding companies as they choose between in-house development and relying on a CRO's muscle.In this episode:How evolving cell and gene therapy timelines are driving the need for true CRO-drug developer partnerships (00:00)The unique challenges of scaling CMC analytics from early trials to global commercialization (02:51)Key pitfalls to avoid when outsourcing to CROs—especially around communication, scheduling, and troubleshooting (06:26)Deciding whether to build capabilities in-house or outsource to a CRO, and how to find the right balance for your team (08:41)The critical importance of strong project management for juggling relationships between developer, CRO, and CDMO (09:51)Daniel's perspective on the future of combination therapies and what the analytical landscape will demand of CROs (13:33)Practical advice for building transparent, open CRO partnerships that support your goals (15:21)Facing scale-up challenges or a first CGT launch? This conversation shares practical strategies to advance therapies efficiently.Tune in for actionable insights on CMC, outsourcing, and analytical development.Connect with Daniel Galbraith:LinkedIn: www.linkedin.com/in/daniel-galbraith-26a6138Solvias website: www.solvias.comEmail: daniel.galbraith@solvias.comNext step:Book a 20-minute call to help you get started on any questions you may have about bioprocessing analytics: https://bruehlmann-consulting.com/callPreparing for your IND? Grab our Startup Founder CMC Dashboard in Notion to help you track tasks, timelines, and risks in one place at https://stan.store/SmartBiotech/p/discovertoind-cmc-dashboard-for-startup-founders

On Rare
"It's good to be alive." Greg is living with LMNA cardiomyopathy

On Rare

Play Episode Listen Later Nov 6, 2025 39:41


Greg's journey with LMNA cardiomyopathy, a rare inherited heart condition, began in high school when he experienced sudden episodes of rapid, irregular heartbeats during track practice. The cause remained a mystery for years, leading to misdiagnoses and untreated disease progression. During that time, Greg faced life-threatening arrhythmias and required several implanted devices before finally receiving a heart transplant. That experience, and the challenges that came before it, ultimately inspired his passion to create change and help others facing the same uncertainty. In this episode of On Rare, David Rintell, Head of Patient Advocacy at BridgeBio, and Mandy Rohrig, Senior Director of Patient Advocacy at BridgeBio, speak with Greg about the long road to diagnosis, the emotional impact of learning he had passed the condition on to his children, and his transformation into an advocate as president of the DCM Foundation. He also shares how his personal experience led to the launch of Everygene, a free genetic testing program for people with cardiomyopathies. Dr. Clayton Beard, Chief Scientific Officer at BridgeBio Gene Therapy, provides a high-level medical overview of LMNA-related dilated cardiomyopathy, a form of heart disease caused by mutations in the LMNA gene that compromise the structural integrity of heart cells and disrupt electrical signaling. He explains how these changes can cause dangerous arrhythmias, weaken the heart muscle, and lead to heart failure, making LMNA cardiomyopathy one of the most severe genetic forms of the condition. Dr. Beard also highlights the importance of early genetic testing for at-risk families, the role of research in improving detection and treatment, and how a better understanding of LMNA can lead to life-saving interventions.

Smart Biotech Scientist | Bioprocess CMC Development, Biologics Manufacturing & Scale-up for Busy Scientists
203: Mastering CRO Selection: Essential Questions for CMC Analytical Development with Daniel Galbraith - Part 1

Smart Biotech Scientist | Bioprocess CMC Development, Biologics Manufacturing & Scale-up for Busy Scientists

Play Episode Listen Later Nov 4, 2025 28:40


Finding an analytical CRO that's truly invested in your success, not just processing samples, makes all the difference in CMC development. In this episode, host David Brühlmann talks with Daniel Galbraith, Chief Scientific Officer at Solvias, about the essential questions and mindset that lead to breakthrough CRO partnerships.With nearly three decades in analytical development, spanning monoclonal antibodies, biosimilars, and cell and gene therapies, Daniel reveals what separates CROs who become true partners from those who just run methods. His insights can save your program months of delays and costly missteps.Key Topics Discussed:Why cell and gene therapies face unique challenges compared to the progression seen with monoclonal antibodies (03:04)Daniel's career path: from entering biotech in 1996 to CSO at Solvias, and the rapid evolution of the industry (05:00)The analytical hurdles in characterizing cell-based products and how their inherent variability impacts development (09:46)Approaches to analytical method requirements for autologous cell therapies, and how data is gathered iteratively in these cases (13:02)The biggest obstacles to scaling up cell and gene therapies, and why innovative cell manipulation technologies are needed (16:06)Current trends in therapeutic modalities: why antibody-drug conjugates stand out, and whether mRNA therapies are losing momentum (18:37)Practical advice on choosing an analytical CRO as a strategic partner - what to look for, what questions to ask, and why enthusiasm and standardization matter (21:55)Wondering how to streamline your own analytical strategy, or navigate the parallel universe of cell and gene therapy development? Dig into this episode for Daniel's insider perspective. Then consider how the right analytical partnership could accelerate your path to clinic.Connect with Daniel Galbraith:LinkedIn: www.linkedin.com/in/daniel-galbraith-26a6138Solvias website: www.solvias.comEmail: daniel.galbraith@solvias.comNext step:Book a 20-minute call to help you get started on any questions you may have about bioprocessing analytics: https://bruehlmann-consulting.com/callPreparing for your IND? Grab our Startup Founder CMC Dashboard in Notion to help you track tasks, timelines, and risks in one place at https://stan.store/SmartBiotech/p/discovertoind-cmc-dashboard-for-startup-founders

Inside Reproductive Health Podcast
268 The IVF Lab in 5 Years. Dr. Denny Sakkas

Inside Reproductive Health Podcast

Play Episode Listen Later Nov 3, 2025 45:24


What will the IVF lab look like in five years?Trying to predict and shape that response is Dr. Denny Sakkas, Chief Scientific Officer at Boston IVF and head of the scientific advisory board for AutoIVF.In this episode of Inside Reproductive Health, Dr. Sakkas about what automation really means for embryologists, and how new technologies could transform lab operations, chain of custody, and patient safety.Dr. Sakkas shares:– The potential downsides to automation and where caution is needed– How AutoIVF differs from AURA by Conceivable Life Sciences–  His prediction about time-lapse imaging within five years– The areas where embryologists must hold firm on lab standards– The next big innovations he's watching (and what Boston IVF plans to purchase next year)

Two Bees in a Podcast
Episode 217: A New Varroa Control Method With Ron Korkidi

Two Bees in a Podcast

Play Episode Listen Later Oct 28, 2025 45:48


In this episode of Two Bees in a Podcast, Amy Vu and Dr. Jamie Ellis discuss a new technology to control Varroa in Australia with Ron Korkidi, Chief Scientific Officer of ToBe Influencing Innovation. This episode ends with a Q&A segment. Check out our website: www.ufhoneybee.com for additional resources from today's episode. 

Tradeoffs
Will Trump's Prescription Drug Deals Really Lower Prices?

Tradeoffs

Play Episode Listen Later Oct 23, 2025 24:23


Facing unprecedented pressure from the Trump administration, some of the world's top drugmakers promise to cut prices. But experts say the savings might not be what they seem.Guests:Michael Cannon, Director of Health Policy Studies, Cato InstituteStacie Dusetzina, Professor of Health Policy, Vanderbilt UniversityDarius Lakdawalla, Chief Scientific Officer, USC Schaeffer CenterPete Loftus, Reporter, Wall Street JournalBen Rome, Assistant Professor of Medicine, Harvard Medical SchoolLeslie Walker, Senior Reporter, TradeoffsWe want to hear from you! Our audience survey takes less than ten minutes, and you'll be entered to win one of two $50 Bookshop.org gift cards.Learn more and read a full transcript on our website.Want more Tradeoffs? Sign up for our free weekly newsletter featuring the latest health policy research and news.Support this type of journalism today, with a gift. Hosted on Acast. See acast.com/privacy for more information.

The Human Upgrade with Dave Asprey
Why Women's Joints Are Failing 10x Faster : 1349

The Human Upgrade with Dave Asprey

Play Episode Listen Later Oct 21, 2025 57:16


Modern joint pain isn't just wear and tear—it's a systemic, metabolic disease that starts years before symptoms show. In this episode, you'll learn how inflammation, mitochondria dysfunction, and immune imbalance trigger cartilage loss… and how to reverse it using targeted cytokine modulation, cellular regeneration, and smarter supplements for longevity and human performance. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Kiran Krishnan, a research microbiologist and Chief Scientific Officer at Calroy Health Sciences. He's the founder of Microbiome Labs—one of the most trusted microbiome-focused brands in functional medicine—and a formulator behind cutting-edge supplements like Arterosil and Vascanox. With over two decades of experience, Kiran has launched multiple health ventures, authored scientific textbook chapters, published clinical trials, and holds global patents in human health. He's a leading authority on systemic inflammation, mitochondrial dysfunction, and gut-driven disease—and one of the few voices making complex biology accessible for real-world results. He breaks down their new supplement Cartigenix HP, and how cytokines like IL-6 and TNF-alpha flip your cartilage cells from anabolic repair to catabolic destruction, how mitochondrial decline speeds up joint damage, and why most modern painkillers make your joints worse. You'll learn how a specialized blend of boswellia and celery seed reprograms inflammation, why walking beats medication in clinical trials, and how fasting, nitric oxide, and gut health work together to optimize joint regeneration. You'll learn: • How cartilage cells (chondrocytes) rely on mitochondria for tissue repair • Why global cytokines like IL-6 and TNF-alpha drive joint degradation and brain fog • How cartilage begins to break down in your teens—and what to do about it now • The surprising clinical data on walking distance, inflammation markers, and recovery • Why most supplements and NSAIDs fail—and what actually rebuilds joints • How diet and leaky gut create 5-day inflammation spikes from a single fast-food meal • The mitochondrial link between joint pain, cardiovascular risk, and depression • Why perimenopausal women are at 10x higher risk for arthritis—and how to prevent it • How to track your biological joint age using imaging and systemic inflammation labs This is essential listening for anyone serious about biohacking, functional medicine, pain-free aging, and human performance. Whether you're lifting heavy, walking daily, or just trying to stay mobile into old age, this episode gives you the science and tools to reverse joint degeneration and extend your healthspan. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Joint cartilage regeneration, IL-6 inflammation suppression, TNF-alpha cytokine modulation, Chondrocyte mitochondrial repair, Catabolic to anabolic tissue shift, Osteoarthritis reversal, Rheumatoid arthritis inflammation, Mitochondria and collagen synthesis, Boswellia seratol extract, Celery seed COX inhibition, Matrix metalloproteinase (MMP) inhibition, Synovial fluid inflammation, Leaky gut and joint pain, Six-minute walk test improvement, Global cytokine markers, High sensitivity CRP reduction, ESR sedimentation rate, Uric acid crystal formation, Post-prandial glucose walking, Cartilage MRI biomarkers, Functional medicine joint support, Fasted repair stacking, Vasodilation and nitric oxide, Anti-inflammatory supplement stacking, NF-kB pathway reduction, Joint space biological age, Microvascular circulation and cartilage, Caloric load and cytokine spike, Perimenopause and arthritis risk, Joint tissue anabolic activation **Get an exclusive discount for podcast listeners at calroy.com/dave : https://calroy.com/product/cartigenix-hp/?lp=dave ** Thank you to our sponsors! -BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off. -BiOptimizers | Go to http://bioptimizers.com/dave and use code DAVE15 to get 15% off your order. -Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. -Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order. Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:25 — Introduction 2:01 — Why Modern Medicine Fails at Joint Pain 3:07 — Painkillers That Accelerate Joint Damage 7:35 — Rheumatoid vs. Osteoarthritis Explained 8:54 — Cytokines That Destroy Cartilage 12:10 — Arthritis Begins in Your Teens 15:35 — 75% Pain Reduction in 7 Days 18:35 — The Science Behind Boswellia & Celery Seed 24:10 — Six-Minute Walk Test Results 25:45 — The $200/Month Painkiller Trap 28:53 — Proof Cartilage Can Regrow 31:01 — Mitochondria and Joint Repair 32:29 — Inflammation Links to Heart Disease 35:52 — Why Glucosamine Doesn't Work 37:07 — Silent Arthritis in 90% of Adults 40:44 — Why Women Face Higher Joint Risk After 40 45:52 — Food as the #1 Inflammation Trigger 47:23 — Fasting & Cartogenics Stack for Repair 50:27 — Movement Snacks and Efficient Training 55:54 — Why Joints Heal Slower Than Muscles 57:48 — Dave's Stack and Final Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Not Your Mother's Menopause with Dr. Fiona Lovely
Ep. 189 - Anti-Aging the Brain with Dr. Siobhan Matthews

Not Your Mother's Menopause with Dr. Fiona Lovely

Play Episode Listen Later Oct 21, 2025 68:36


In this episode of Not Your Mother's Menopause,  Dr. Fiona Lovely is joined by Dr. Siobhan Matthews, a neuroscientist and Chief Scientific Officer at MitoQ, for a profound discussion on the pivotal role of mitochondria in brain health and aging. Dr. Matthews, whose career was inspired by her grandmother's experience with Alzheimer's, shares her extensive research journey on mitochondrial science, anti-aging the brain and nutritional neuroscience. The conversation illuminates the critical connection between mitochondrial health and the cognitive changes many women experience during perimenopause and menopause. Dr. Matthews explains how the decline in estrogen can directly impact mitochondrial function in the brain, potentially leading to symptoms like brain fog and fatigue. She provides insightful information on how supporting cellular energy production and protecting against oxidative stress can be a powerful strategy for maintaining cognitive vitality. The discussion also explores the broader implications of mitochondrial health for heart function, immune resilience, and overall longevity, offering a fresh perspective on proactive wellness for women navigating midlife and beyond. Find out more about MitoQ at mitoq.com - there is lots to learn!  (code: LOVELY for a discount!) Thank you to our sponsors for this episode:

Curing with Sound
Ep40: Therapeutic Ultrasound for Glioblastoma: Carthera's Comparative Clinical Trial

Curing with Sound

Play Episode Listen Later Oct 21, 2025 16:44


In this episode of Curing with Sound, we explore a groundbreaking approach to one of medicine's toughest cancers, glioblastoma (GBM), with Michael Canney, PhD, Chief Scientific Officer at Carthera. GBM is the most aggressive form of brain cancer, notoriously hard to treat because the blood-brain barrier (BBB) blocks many life-saving drugs from reaching tumor cells. With survival rates of just one to two years, new approaches are urgently needed. Dr. Canney shares how Carthera's SonoCloud-9, an implantable, therapeutic ultrasound device, temporarily opens the BBB and enhances the delivery of circulating drugs to the brain. He also discusses the SONOBIRD clinical trial, comparing the use of Carthera's SonoCloud-9 device combined with chemotherapy to standard-of-care therapies in patients with recurrent GBM. Discussion highlights: Phase III SONOBIRD Trial: The largest clinical trial in Carthera's history, enrolling 560 patients across the United States and Europe. The trial's goal is to demonstrate a survival advantage for patients with recurrent GBM when BBB opening is combined with the delivery of carboplatin chemotherapy, as compared with standard of care. Revolutionizing Drug Delivery: How SonoCloud-9 opens the BBB to increase carboplatin concentrations five- to seven-fold, potentially unlocking the full potential of existing cancer drugs that previously couldn't reach brain tumors. EPISODE TRANSCRIPT ---------------------------- QUESTIONS? Email podcast@fusfoundation.org if you have a question or comment about the show, or if you would you like to connect about future guest appearances.  Email info@fusfoundation.org if you have questions about focused ultrasound or the Foundation.  FUSF SOCIAL MEDIA LinkedIn X Facebook Instagram TikTok YouTube FUSF WEBSITE https://www.fusfoundation.org SIGN UP FOR OUR FREE NEWSLETTER https://www.fusfoundation.org/newsletter-signup/ READ THE LATEST NEWSLETTER https://www.fusfoundation.org/the-foundation/news-media/newsletter/ DOWNLOAD "THE TUMOR" BY JOHN GRISHAM (FREE E-BOOK) https://www.fusfoundation.org/read-the-tumor-by-john-grisham/

The Hunting Dog Podcast
Snakebite Masterclass.

The Hunting Dog Podcast

Play Episode Listen Later Oct 9, 2025 111:12


Josh Lizer is the Chief Scientific Officer at MG Biologics. Josh takes us through everything about snake bites. From A-Z you will go in the field more confident than ever before. If this happens to your dog. National Snakebite Support www.nationalsnakebitesupport.org National Snakebite Support Facebook group (be sure to answer ALL the questions to join or your request will not be approved) https://www.facebook.com/groups/987850051297436/ Antivenom locator: www.veterinarysnakebite911.com Email Josh @ josh.lizer@mgbiologics.com or techsupport@mgbiologics.com               email me : josh.lizer@mgbiologics.com or techsupport@mgbiologics.com    

The Inquiry
Why are more people getting Lyme disease?

The Inquiry

Play Episode Listen Later Sep 30, 2025 22:58


Lyme disease is a bacterial infection passed on to humans by infected ticks. Symptoms can range from fatigue, joint pain and a circular shaped rash to facial paralysis and heart arrythmia. According to a British Medical Journal (BMJ) global health review, Lyme disease has likely infected about one in 10 people across the globe. Recently, pop star Justin Timberlake went public about contracting the condition. If treated quickly, most people will recover but there are still issues around diagnosing and treating Lyme disease. And globally, cases are on the rise. In this edition of The Inquiry, Charmaine Cozier explores what's behind the increase and hears about new tests and vaccines currently being developed. Contributors: Dr Sally Mavin, clinical scientist and Director of the Scottish Lyme Disease and Tick-Borne Infections Reference Laboratory, Raigmore Hospital, Inverness, Scotland Dr Armin Alaedini, Chief Scientific Officer, Global Lyme Alliance Dr Gábor Földvári, research group leader, Centre for Ecological Research, Institute of Evolution, Budapest, Hungary Dr Alessandra Luchini, Professor, School of Systems Biology, George Mason University, USA. Presenter: Charmaine Cozier Producers: Jill Collins and Emma Forde Researcher: Maeve Schaffer Technical producer: Richard Hannaford Production Coordinator: Tammy Snow Editor: Tara McDermott

Hit Play Not Pause
Psychedelics 101 for Menopause: Myths, Mechanisms, Must-Knows Grace Blest-Hopley, PhD (Episode 241)

Hit Play Not Pause

Play Episode Listen Later Sep 10, 2025 68:40


Buckle up for a trip (pun intended) into the midlife brain. This week we sit down with neuroscientist Dr. Grace Blest-Hopley to connect the dots between cannabinoids, psychedelics, trauma, and the menopause transition. We cover CBD/THC for sleep, anxiety, pain, and inflammation; how the endocannabinoid system works, and how psychedelics like psilocybin act on serotonin pathways, reduce neuroinflammation, and promote neuroplasticity—potentially countering some brain changes seen with estrogen loss. We also dig into trauma (including why PTSD risk and expression differ by sex), the importance of set, setting, and skilled facilitation, who should not use psychedelics, the legal/clinical landscape, and much more. Curious about midlife brain health and whether these therapies are worth exploring? This one's for you.Dr. Grace Blest-Hopley is a neuroscientist with 12 years experience researching cannabis, cannabinoids, and psychedelics. Grace completed her PhD in Neuroscience at King's College London and currently serves as the Chief Scientific Officer at NWPharma Tech. She is the Research Director at Heroic Hearts Project, a charity that supports combat veterans with mental health challenges resulting from trauma and is also the founder of Hystelica, a community focused on understanding women's biology for safe and effective psychedelic use. In addition to her research and professional roles, she has served as an officer in the British Army Reserve. Dr. Blest-Hopley advocates for the therapeutic potential of these substances and strives to advance the field of psychedelic research. Her work contributes to promoting a better understanding of women's biology in relation to psychedelics. You can learn more about her and her work at hystelica.comSign up for our FREE Feisty 40+ newsletter: https://feistymedia.ac-page.com/feisty-40-sign-up-pageLearn More and Register for our Feisty 40+ Strong Retreat: https://www.womensperformance.com/strongretreat Learn More and Register for our 2026 Tucson Bike Camp: https://www.girlsgonegravel.com/camp Follow Us on Instagram:Feisty Menopause: @feistymenopause Hit Play Not Pause Facebook Group: https://www.facebook.com/groups/807943973376099 Support our Partners:Phosis: Use the code FEISTY15 for 15% off at https://www.phosis.com/ Midi Health: You Deserve to Feel Great. Book your virtual visit today at https://www.joinmidi.com/Hettas: Use code FEISTY20 for 20% off at https://hettas.com/ Previnex: Get 15% off your first order with code HITPLAY at https://www.previnex.com/ Nutrisense: Go to nutrisense.io/hitplay and use code: HITPLAY to get 30% off This podcast uses the following third-party services for analysis: Spotify Ad Analytics - https://www.spotify.com/us/legal/ad-analytics-privacy-policy/Podcorn - https://podcorn.com/privacyPodscribe - https://podscribe.com/privacy

The Doctor's Farmacy with Mark Hyman, M.D.
Inside the New Era of Precision Medicine: Where AI and Human Insight Unite

The Doctor's Farmacy with Mark Hyman, M.D.

Play Episode Listen Later Aug 11, 2025 64:43


Medicine stands at the threshold of a new era, where artificial intelligence and systems biology are working hand in hand to make care more personal, predictive, and precise than ever before. AI is already improving diagnostic accuracy, automating administrative tasks, and uncovering patterns in data—like retinal scans or genomics—that humans often miss. Rather than replacing doctors, AI enhances their ability to deliver more informed, precise, and efficient care. At the same time, individuals are gaining tools—from at-home diagnostics to wearable biosensors—that empower them to track and optimize their own health. This shift marks a move from reactive, disease-centered care to a proactive, data-driven model of scientific wellness. In this episode, I talk with Dr. Eric Topol, Dr. Nathan Price, Dr. Leroy Hood, Dr. Vijay Pande, and Daisy Wolf about how artificial intelligence, personalized data, and wearable technology are converging to radically transform medicine. Dr. Eric Topol is Executive Vice President of Scripps Research and founder/director of its Translational Institute, recognized as one of the top 10 most cited researchers in medicine with over 1,300 publications. A cardiologist and author of several bestselling books on the future of medicine, he leads major NIH grants in precision medicine and shares cutting-edge biomedical insights through his Ground Truths newsletter and podcast. Dr. Nathan Price is Chief Scientific Officer at Thorne HealthTech, author of The Age of Scientific Wellness, and a National Academy of Medicine Emerging Leader. He also serves on the Board on Life Sciences for the National Academies and is Affiliate Faculty in Bioengineering and Computer Science at the University of Washington. Dr. Leroy Hood is CEO and founder of Phenome Health, leading the Human Phenome Initiative to sequence and track the health of one million people over 10 years. A pioneer in systems biology and co-founder of 17 biotech companies, he is a recipient of the Lasker Prize, Kyoto Prize, and National Medal of Science. Dr. Vijay Pande is a General Partner at Andreessen Horowitz and founder of a16z Bio + Health, managing over $3 billion in life sciences and healthcare investments at the intersection of biology and AI. An Adjunct Professor at Stanford, he is known for his work in computational science, earning honors like the DeLano Prize and a Guinness World Record for Folding@Home. Daisy Wolf is an investing partner at Andreessen Horowitz, specializing in healthcare AI, consumer health, and healthcare-fintech innovation. She previously worked at Meta and in various startups, holds a JD from Yale Law, an MBA from Stanford, and a BA from Yale, and is based in New York City. This episode is brought to you by BIOptimizers. Head to bioptimizers.com/hyman and use code HYMAN10 to save 10%. Full-length episodes can be found here: Can AI Fix Our Health and Our Healthcare System? The Next Revolution In Medicine: Scientific Wellness, AI And Disease Reversal The Future of Healthcare: The Role of AI and Technology