Podcasts about Frye

In today's episode, I'm opening the first chapter of what I believe is the most important series I've ever created — a deep dive into progesterone and why it became the heart of my medical practice. For more than 20 years, I've watched this “simple, humble hormone” transform women's lives in ways most conventional medicine overlooks. What started in two small treatment rooms has grown into a 25,000 sq ft facility, and the core of our success comes down to understanding progesterone's impact on the female brain, stress response, and emotional resilience. In this episode, I break down: Why progesterone is far more than a reproductive hormone How it regulates the female stress response (amygdala, hippocampus, prefrontal cortex) Why anxiety, insomnia, irritability, and emotional overwhelm often map directly to progesterone decline Why so many women feel “unraveled” in their 40s — and why it's not their fault The science behind oral vs. sublingual progesterone (and why I use troches) How conventional medicine often misses the root cause The importance of physicians showing their work, their data, and their citations The lived stories and clinical outcomes that changed how I practice medicine If you've ever felt dismissed, unseen, or told that your anxiety or mood changes are “just stress,” this episode is for you. This is the beginning of a 7-part series where I break down the neurobiology, endocrinology, testing, dosing, delivery methods, breast health, perimenopause, and more.   Citations: Brinton, Roberta Diaz, et al. “Neurosteroids and Brain Function.” Steroids, vol. 81, 2014, pp. 61–78. Epperson, C. Neill, et al. “New Insights into Perimenopausal Depression: A Neuroendocrine Vulnerability Framework.” The Lancet Psychiatry, vol. 9, no. 2, 2022, pp. 110–118. Frye, Cheryl A. “Neurosteroids—Endogenous Modulators of GABA_A Receptors.” Pharmacology & Therapeutics, vol. 116, no. 1, 2007, pp. 58–76. Genazzani, Andrea R., et al. “Progesterone, Stress, and the Brain.” Human Reproduction Update, vol. 16, no. 6, 2010, pp. 641–655. Meeker, John D., et al. “Environmental Endocrine Disruptors: Their Effects on Human Reproduction and Development.” Reproductive Toxicology, vol. 25, 2008, pp. 1–7. Mellon, Stanley H. “Neurosteroid Regulation of Central Nervous System Development.” Pharmacology & Therapeutics, vol. 116, 2007, pp. 107–124. Mizrahi, Romy, et al. “The Role of Allopregnanolone in Stress, Mood, and Trauma.” Neurobiology of Stress, vol. 11, 2019, 100198. Paul, Steven M., and Graziano Pinna. “Allopregnanolone: From Molecular Pathways to Therapeutic Applications.” Current Opinion in Neurobiology, vol. 48, 2018, pp. 90–96. Pluchino, Nicoletta, et al. “Progesterone and Allopregnanolone: Effects on the Central Nervous System in the Luteal Phase and in Perimenopause.” Gynecological Endocrinology, vol. 36, no. 6, 2020, pp. 441–445. Rasgon, Natalie L., et al. “Perimenopausal Changes in the Brain and Mood: A Review.” Journal of Clinical Endocrinology and Metabolism, vol. 107, no. 4, 2022, pp. 1120–1134. Reddy, Doodipala Samba. “The Neurosteroid Allopregnanolone and GABA-A Receptor Modulation in Epilepsy and Mood Disorders.” Frontiers in Neuroscience, vol. 12, 2018, 933. Schiller, Crystal E., et al. “The Neuroendocrinology of Perimenopausal Depression.” Trends in Neurosciences, vol. 44, no. 2, 2021, pp. 119–135. Schumacher, Michael, et al. “Neuroprotective Effects of Progesterone and Its Metabolites.” Frontiers in Neuroendocrinology, vol. 33, 2012, pp. 415–439. Selye, Hans. “The General Adaptation Syndrome and the Diseases of Adaptation.” Journal of Clinical Endocrinology, vol. 6, no. 2, 1946, pp. 117–230. Sheng, Jun, and György Buzsáki. “Neuronal Firing and Theta Oscillations in the Amygdala During Fear Conditioning.” Neuron, vol. 53, 2007, pp. 653–667. Smith, Sheryl S. “Progesterone Withdrawal Increases Neuronal Excitability in the Hippocampus: A GABA_A Mechanism.” Journal of Neuroscience, vol. 28, 2008, pp. 10171–10179. Snyder, Jonathan S., et al. “Adult Hippocampal Neurogenesis and Stress Regulation.” Nature Reviews Neuroscience, vol. 12, 2011, pp. 1–9. Stanczyk, Frank Z., and Jerilynn C. Prior. “Progesterone and Progestins: A Review of Pharmacology, PK, and Clinical Use.” Steroids, vol. 82, 2014, pp. 1–8. Tu, Ming-Je, et al. “Oral, Vaginal, and Transdermal Progesterone: PK, Metabolism, and Tissue Distribution.” Drug Metabolism Reviews, vol. 52, no. 2, 2020, pp. 1–28. Wang, Jun, et al. “Stress, Amygdala Plasticity, and the Neuroendocrine Interface.” Nature Neuroscience, vol. 10, 2007, pp. 1093–1100. Weinstock, Marta. “The Hippocampus and Chronic Stress.” Neurochemical Research, vol. 42, 2017, pp. 1–12. World Health Organization. Progesterone and Reproductive Function: Clinical Perspectives. WHO, 2019.   Dr. Brendan McCarthy is the founder and Chief Medical Officer of Protea Medical Center in Arizona. With over two decades of experience, he's helped thousands of patients navigate hormonal imbalances using bioidentical HRT, nutrition, and root-cause medicine. He's also taught and mentored other physicians on integrative approaches to hormone therapy, weight loss, fertility, and more. If you're ready to take your health seriously, this podcast is a great place to start.  

VLOG 3 Luigi Mangione Day 3 of suppression hearing, Frye all day, McDonalds Roshomon - after unsealing order and judge's assurance, story here https://matthewrussellleeicp.substack.com/p/extra-in-luigi-mangione-hearing-day, now exhibits unsealed - 911: https://soundcloud.com/innercitypress/luigi-mangione-911-call-altoona-unsealed-after-inner-city-press-unsealing-letter-to-justice-carroAltoona PA audio https://soundcloud.com/innercitypress/in-luigi-mangione-case-altoona-pd-radio-audio-unsealed-after-inner-city-press-unsealing-letter

On this week's TTP, we're breaking down the big UFC 323 card. Plus, we're chatting with TUF winner Mairon Santos, who is on this card, and AJ Frye, who makes his UFC debut next week. TIME STAMPS: Mairon Santos Interview - 1:46 Fights, Dogs, and Parlays: UFC 323 - 18:47 AJ Frye Interview - 28:02 AND CHECK OUT LEANS AI https://leans.ai/?lnkref=TURTLE

Darren Frye, Water Street SolutionsSee omnystudio.com/listener for privacy information.

Jeff Gaffney & Dr. Wayne Frye, Senior Pastor at Faith Christian Center International, were live on The Everyday Faith Show! The Everyday Faith Show airs live Monday from 10:15 am – 11:00 am on The I Love CVille Network. “The Everyday Faith Show” is presented by Faith Christian Center International, Glenmore Realty & Real Estate III.

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We are Virginia Sole-Smith and Corinne Fay and it's time for your Indulgence Gospel — Thanksgiving Edition! We often skip an episode drop on this day, but given how high pressure Thanksgiving can be for food, bodies and people, we thought...maybe you need a little Indulgence Gospel, a little Butter, and a little distraction from whatever your holiday weekend entails?We've got you: A Helen Rosner-inspired fashion epiphany. Thoughts and feelings about Black Friday. A very good Corinne clothing rant.Our secret shame places. And more! You do need to be a paid Just Toast subscriber to listen to this full conversation. Membership starts at just $5 per month! Join Just Toast! Don't want an ongoing commitment? Click "buy for $4!" to listen to just this one.

Founder of #shegone Nation Jeff Frye hosts Will "The Thrill" Clark. The former teammates play the nickname game, Kenny Roger's perfect game, & who Jeff's favorite Clark really is. Learn how "The Thrill" helped Jeff learne how to take care of his lumber and veteran lockerroom messages regarding fraternization with the opposing the team. We get into hitter's meetings prior to the game and the importance of watching the opposing pitcher's 8 warm up pitches. Will is very candid about how we're babying the sport, how he'd do against modern pitching, and his thoughts on modern day analytics. Stay tuned until the end to hear great advice for baseball parents.

The most prolific hitting backstop of all-time, Mike Piazza graces the #shegone podcast in between training sessions with WBC team Italy. The new skipper shares stories on the people who influenced his approach to the game. You'll hear names like Reggie Smith, Bill Madlock, Tommy LaSorda, Don Drysdale, Ted Williams, and of course, his dad. Hear about BP vs Sandy Koufax and a hitting lesson from the Splendid Splinter as a teenager. The 62nd round draft choice is very candid about his journey and treats us to a special story surrounding his time with the Mets and 9/11. Jeff Frye does it again ... you'll walk away an even bigger fan of Piazza than when you started after this interview.

#shegone founder Jeff Frye sits down with 1987 World Champion Gary Gaetti. The 4 time Gold Glover shares his sense of reverence for greats like Rod Carew, Kirby Puckett, Tony Oliva, Ceasar Tobar. Gaetti dishes on the special relationship he had with Dan Gladden as a teammate and the even tighter bond they now share in life after baseball. His passion for the gme comes through loud and clear- hear tips on bunting, stealing, hitting, and sliding ... all with the same theme of advice ... know your game and play to it. One of the greatest 3rd basemen of the 80's and 90's, this eventual Hall of Famer prided himself on toughness but admitted that fear plays a key part in baseball, especially vs certain flame throwers- Eckersley, Goose, Morris, Darwin, the Rocket, and Nolan Ryan. Stay tuned until the end and listen to a pitch by pitch breakdown gainst the Ryan Express in spring training his rookie year. Frye brings out some great stories and baseball nuggets from his friend, former teammate and one time hitting instructor. Please take a look at www.GSA.com The Gaetti Sports Academy. It recently opened its doors in Gary's hometown in Illinois to educate the youth on the right way to play the game ... the Gaetti Way.

#shegone founder Jeff Frye hosts long time Phillies great Larry Bowa. The two talk about rule changes that have taken away both toughness and technique from the game- plays at the plate and 2nd base. They mull over the proper role of analytics in the game. They share a common mindset in that players at the lower levels are being rushed through the system & that we're too focused on teaching players about individual metrics ... rather than teaching them how to win. Great tributes to Dave Dombrowski, Charlie Manuel, Rob Thompson, Perry Hill, and Ryne Sanberg. At the end, two former big league middle infielders dish on the how the love of the game, discipline, and effort are the common denominators needed for success ... experience builds both toughness and intuition.

Veteran MLB 2nd Baseman and founder of #shegone nation Jeff Frye entertains Baseball Agent & son of the legendary Yankee Skipper, Billy Martin Jr. The two talk about the nuances of being a sports agent and how Billy may have assisted Jeff into landing the 2nd Base job with the Rangers late in his career. Martin, Jr tells stories of being in the Yankee Club House as a kid and what he'd share with Ken Griffey, Jr if he got the chance. Hold on tight as we hear about his breakfasts with Ted Williams and his impromtu hitting lesson in a diner. Hear opinions on who the true HR record holder is and foreshadowing to a Hall of fame induction ceremony including the Greatest Manager of All-Time Billy Martin. Stay tuned until the end as Dave makes an appearance to get Billy to help his son Tanner with his latest home school project ... What is Billy Ball? Billy Jr takes us into the genius that was his father and his invention of Billy Ball. Take notes and appreciate the banter of two old friends and understand how loyalty drives both Jeff and Billy... filled with stories that are both refreshing and entertaining. #shegone

Grains traded narrowly mixed, while live and feeder cattle closed mostly higher in Tuesday trade. Darren Frye with Waterstreet Advisors breaks down the day. Topics: Impact of Russia/Ukraine Peace deal Soybeans still correcting Corn found a bottom? Cattle rebound, still ugly charts Keys for holiday week trade

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