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AudioMedica.com


    • Feb 24, 2020 LATEST EPISODE
    • infrequent NEW EPISODES
    • 5m AVG DURATION
    • 51 EPISODES


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    Latest episodes from AudioMedica.com

    CT Screening Cuts Lung Cancer Deaths 24 Per Cent—Second Study Confirms

    Play Episode Listen Later Feb 24, 2020 0:20


    UK & NETHERLANDS—Following the the AJO Podcast interview with Professor Harry de Koning MD PhD, from the Erasmus University in Rotterdam, who discussed his research published in the New England Journal of Medicine that supports the widespread introduction of computed …

    Volume CT Lung Cancer Screening Cuts Cancer Deaths 24 Per Cent

    Play Episode Listen Later Feb 7, 2020 16:39


    Second Study Confirms Lung Cancer CT Screening Cuts Deaths NETHERLANDS—Erasmus University Medical Center, Rotterdam—Research published in the New England Journal of Medicine has confirmed the viability of computed tomographic (CT) screening for detecting cases of lung cancer early in high-risk …Harry J. de Koning MD PhD

    New Front Line Standard for Older Patients with Chronic Lymphocytic Leukemia

    Play Episode Listen Later Jan 24, 2020 3:00


      Audio Journal of Oncology   SAN DIEGO—The first-line treatment of choice for older patients with chronic lymphocytic leukemia (CLL) should now be single agent ibrutinib according to conclusions drawn from the Alliance North American Intergroup Study A041202 reported at …Woyach AJO Prouction MASTER

    Microbiome Diversity Key To Survival After Allogeneic Hematopoietic Cell Transplantation

    Play Episode Listen Later Jan 14, 2020 10:00


    Microbiome Diversity Key To Survival After Allogeneic Hematopoietic Cell Transplantation The Audio Journal of Oncology Podcast SAN DIEGO—Overall survival after allogeneic hematopoietic cell transplantation (allo-HCT) was found to be adversely influenced by a lack of diversity in the intestinal microbiota—before, …Jonathan Peled AudioMedica AJO Podcast

    Genomic-led AML Clinical Decision Making Within Seven Days

    Play Episode Listen Later Dec 31, 2019 11:00


    Audio Journal of Oncology Reporting from 2018 annual meeting of the American Society of Hematology SAN DIEGO—Individualized therapy decisions that are founded on “genomic fingerprint” data can now be made within seven days for most patients with suspected diagnoses of …John C Byrd Sunday ASH AJO WordPress MASTER

    Ibrutinib: New Frontline Standard for Chronic Lymphocytic Leukemia?

    Play Episode Listen Later Oct 7, 2019 10:00


    SAN DIEGO—Patients 70 years old and younger with previously untreated chronic lymphocytic leukemia (CLL) lived longer and had progression of their disease delayed when treated with ibrutinib (an irreversible inhibitor of Bruton’s tyrosine kinase [BTK]) combined with the anti-CD 20 …Shanafelt AJO PodcastMASTER

    Ibrutinib: New Frontline Standard for Chronic Lymphocytic Leukemia?

    Play Episode Listen Later Oct 7, 2019 10:00


    SAN DIEGO—Patients 70 years old and younger with previously untreated chronic lymphocytic leukemia (CLL) lived longer and had progression of their disease delayed when treated with ibrutinib (an irreversible inhibitor of Bruton’s tyrosine kinase [BTK]) combined with the anti-CD 20 …

    Head and Neck Cancer Therapy De-Escalation: A “Salutary Lesson”

    Play Episode Listen Later Nov 12, 2018 0:05


    MUNICH—A “salutary lesson” was reported by researchers investigating therapy for oropharyngeal cancer at the 2018 annual congress of the European Society for Medical Oncology (ESMO). It came from results of the De-ESCALaTE HPVstudy that found patients with low-risk head and …Hisham Mehanna discusses head and neck cancer de-escalation

    Which New Combination for Metastatic Renal Cell Cancer?

    Play Episode Listen Later Nov 12, 2018 0:09


    MUNICH—A leading European oncologist acknowledged the impressive life-extending potential of new drug combinations for metastatic renal cell carcinoma discussed at the 2018 annual congress of the European Society for Medical Oncology (ESMO). Progress was reported with purely immunological approaches—using two …John Haanen Audio Journal of Oncology

    Two Drug Combination Doubled Kidney Cancer Progression Free Survival

    Play Episode Listen Later Nov 7, 2018 0:09


    MUNICH— A doubling of progression free survival (PFS) and objective response rate (ORR) was observed in patients who had their previously untreated advanced renal cell cancer (RCC) treated with a combination of the vascular endothelial growth factor (VEGF) inhibitor axitinib …Robert Motzer ESMO AJO

    ALK—Targeted Lung Cancer Drugs Benefited Real World Patients 

    Play Episode Listen Later Nov 7, 2018 0:09


    MUNICH— Anaplastic lymphoma kinase (ALK) inhibitors are as effective in “real world” clinical use for treating patients with non-small cell lung cancer (NSCLC) who test positive for ALK gene rearrangements as they are in clinical studies—even though randomized trials “cherry …Mohammad Jahanzeb AJ0

    First Line PARP Inhibition For Ovarian Cancer Assessed

    Play Episode Listen Later Nov 2, 2018 0:07


    MUNICH—The role of poly ADP ribose polymerase (PARP) inhibitors for treating newly diagnosed advanced ovarian cancer was under review at the 2018 annual congress of the European Society for Medical Oncology (ESMO) in the light of findings from the SOLO1 …Jonathan Ledermann AJO

    BRCA1/2 Ovarian Cancer—Three Years Disease Free with First-Line Olaparib

    Play Episode Listen Later Nov 1, 2018 0:08


    BRCA1/2 Ovarian Cancer—Three Years Disease Free with First-Line Olaparib MUNICH—An “unprecedented improvement” in progression free survival (PFS) was observed in the randomized controlled double-blind phase three SOLO1 study of women with newly diagnosed ovarian cancer who had BRCA1/2 mutations and …Kathleen Moore OLAPARIB FIRST LINE IN OVAIAN CANCER

    PD-L1 Immunotherapy Delayed Triple Negative Breast Cancer Progression

    Play Episode Listen Later Oct 31, 2018 0:06


    MUNICH— Immunotherapy with the anti programmed death ligand 1 (PD-L1) checkpoint inhibitor atezolizumab in combination with nab-paclitaxel chemotherapy prolonged progression-free survival (PFS) among patients with metastatic triple-negative breast cancer in the randomized phase three IMpassion130 trial reported at the 2018 …Peter Schmid AJO Atezolizumab Extends Lif e in Triple Negative Breast Cancer

    Genomically Targeted Therapy Delays Advanced Breast Cancer Progression

    Play Episode Listen Later Oct 31, 2018 0:06


        MUNICH—A combination of the phosphoinositide 3-kinase (PI3K) inhibitor alpelisib plus fulvestrant significantly extended progression free survival (PFS) compared to placebo plus fulvestrant in patients with hormone receptor positive (HR+) human epidermal growth factor receptor 2-negative (HER2−) advanced breast …Fabrice André ESMO 2018 AJO Genomic Breast Cancer Targeting

    Palbociclib Combination Prolongs Life After Breast Cancer Hormone Therapy

    Play Episode Listen Later Oct 29, 2018 0:07


    MUNICH—Patients with hormone receptor-positive (HR+) human epidermal growth factor receptor 2-negative (HER2−) advanced breast cancer who were treated with a combination of the cyclin dependent kinase (CDK) 4/6 inhibitor palbociclib in combination with fulvestrantlived longer than those receiving a placebo …Massimo Cristofanilli AJO PRODUCTION MASTER

    Long Overall Survival in Ceritinib-Treated ALK-Positive Lung Cancer

    Play Episode Listen Later Oct 27, 2018 0:07


    MUNICH—More than four years median overall survival was reported in patients treated with an inhibitor of anaplastic lymphoma kinase (ALK) for their ALK gene rearranged non-small cell lung cancer (NSCLC) in a single-arm phase two study reported at the 2018 …181019 Enriqueta Felip AJO PRODUCTION MASTER

    Pembrolizumab: No Survival Gains Second Line In Gastric Cancer

    Play Episode Listen Later Oct 18, 2018 0:07


    Reporter: Sarah Maxwell BARCELONA—Pembrolizumab did not significantly improve overall survival (OS) or progression free survival (PFS) compared with paclitaxel as second-line therapy in patients with advanced gastric or gastro-esophageal junction cancer that had progressed after one line of chemotherapy (containing …Kohei Shitara Audio Journal of Oncology

    Cabozantinib Improved Hepatocellular Carcinoma Survival Beyond Sorafenib

    Play Episode Listen Later Oct 15, 2018 0:08


    BARCELONA—Oral cabozantinib “significantly improved” overall survival (OS) and progression free survival (PFS) compared to placebo in patients with advanced hepatocellular carcinoma(HCC) whose disease had progressed despite sorafenib therapy in the phase 3 CELESTIAL trial reported to the 2018 ESMO World …Pilippe Marle AJO PRODUCTION MASTER

    Trifluridine with Tipiracil Lifts Survival in Refractory Gastric Cancer

    Play Episode Listen Later Oct 11, 2018 0:12


    BARCELONA—A chemotherapy combination consisting of trifluridine with tipiracil showed a “clinically meaningful and statistically significant” improvement in overall survival (OS) and progression free survival (PFS) compared with placebo in patients with heavily-pretreated metastatic gastric cancer (mGC) refractory to standard therapies …Josep Tabernero Audio Journal of Oncology

    Esophageal Cancer Prevented By Proton Pump Inhibitor Plus Aspirin

    Play Episode Listen Later Aug 15, 2018 8:54


    CHICAGO—A 25 per cent risk reduction for esophageal cancer was found to be associated with prophylactic therapy consisting of a proton pump inhibitor (PPI) and aspirin in the phase three randomized ASPECT multicenter study from the United Kingdom reported at …Jaanusz Jankowski AJO PRODUCTION MASTER 8'54

    Preoperative Chemoradiotherapy Extends Survival in Pancreatic Cancer

    Play Episode Listen Later Jul 25, 2018 0:05


    CHICAGO—Patients with resectable and “borderline resectable” pancreatic cancers treated with chemoradiation before surgery (followed by adjuvant chemotherapy) had significantly improved outcomes compared to those randomized to have surgery first and adjuvant chemotherapy in the Dutch Pancreatic Cancer Group’sPREOPANC-1 randomized, controlled, …180722 Geertjan Van Tienhoven AJO Production Master

    Whole Genome Sampling Identifies Targetable Prostate Cancer Subgoups

    Play Episode Listen Later Jul 20, 2018 0:07


    CHICAGO—Clinically targetable mutations were identified and patient subgroups pinpointed by whole genome sampling (WGS) of castration-resistant metastatic prostate cancer (mPC) in a study reportedatthe 2018 Annual Meeting of the American Society of Clinical Oncology. (https://meetinglibrary.asco.org/record/160671/abstract) Lisanne F van …Lisanne F van Dessel AJO Production MASTER

    Test Spares Extended Endocrine Therapy In Low-Risk ER+ Breast Cancer

    Play Episode Listen Later Jul 18, 2018 0:09


    CHICAGO—A gene test that predicts for relapse in women with estrogen receptor positive early breast cancer can identify patients with low-risk disease who could safely avoid extending their endocrine therapy beyond the standard five years, according to study findings reported …Graham Poage ASCO AJO Production MASTER

    Superior Survival in Conservatively Treated Male Breast Cancer

    Play Episode Listen Later Jul 13, 2018 0:06


    CHICAGO—Men who had breast-conserving therapy (BCT) including radiation for their early breast cancer lived longer than those who had total or partial mastectomy—with or without radiation—in findings from a large retrospective survey of male breast cancer reported at the 2018 …Sarah Bateni & Candice Sauder AJO

    bct male breast cancer
    Gender Disparity in Head and Neck Cancer Treatment and Outcomes

    Play Episode Listen Later Jun 9, 2018 0:07


    CHICAGO—Women and men were treated differently for the same tumor stages of head and neck cancer (HNC) and had different outcomes in a study with patients surveyed over a fifteen-year period in Santa Clara, California. The findings—using the generalized competing …Jed Katzel AJO PRODUCTION MASTER

    Pembrolizuab Monotherapy Extended Survival in Advanced Lung Cancer

    Play Episode Listen Later Jun 8, 2018 14:00


    CHICAGO, IL—Patients whose non-small cell lung cancers (NSCLC) expressed more than one per cent of the programmed death ligand-1 (PD-L1) tumor proportion score (TPS) lived longer when treated with the anti programmed death 1 (PD-1) antibody pembrolizumab than a control …AJO Gilberto Lopes and John Heymach PRODUCTION MASTER

    Radiotherapy Cuts BRCA-Associated Contralateral Breast Cancer Risk

    Play Episode Listen Later Jun 6, 2018 7:00


    CHICAGO—Prophylactic contralateral (CLT) breast radiotherapy was associated with significantly fewer and delayed cases of breast cancer in women having standard therapy for their ipsilateral BRCA mutation-associated breast cancers in a study from Israel reported in a poster session at the …Ella Evron PRODUCTION MASTER for AJO

    Handgrip Strength Predicts Survival in Elderly Patients with Lung Cancer

    Play Episode Listen Later May 29, 2018 10:00


    BARCELONA—Handgrip strength (HGS) was found to be an independent quantitative marker for overall survival among patients with early-stage non-small cell lung cancer (NSCLC) being treated with stereotactic body radiotherapy (SBRT) in a study discussed at the 2018 European Society for …Stéphanie Peeters AJO Production MASTER

    Brachytherapy “Excellent” After Breast Conserving Surgery

    Play Episode Listen Later May 23, 2018 14:00


    BARCELONA—Accelerated partial breast irradiation (ABPI) brachytherapy completed in a single week gave at least as good efficacy and safety as other radiotherapy protocols after breast-conserving therapy (BCS) for patients with low-risk breast cancer and brought advantages in terms of symptoms …Rebekka Schäfer AJO INTERVIEW Production MASTER

    Cervical Cancer: No Ureteral Stricture Increase With IG Brachytherapy

    Play Episode Listen Later May 23, 2018 20:00


    BARCELONA—Image-guided adaptive brachytherapy (IGABT) for patients with cervical cancer did not increase risk for ureteral stricture (a rare but feared complication of pelvic radiotherapy) in European research reported at the European Society for Radiotherapy & Oncology (ESTRO 37) 2018 conference.…Lars Fokdal AJO INTERVIEW Production Master

    Lung Cancer: Geriatric Assessment Before Concurrent Chemo-Radiotherapy

    Play Episode Listen Later May 22, 2018 15:00


    BARCELONA—It is essential to conduct a comprehensive geriatric assessment of patients over 74 with lung cancer before deciding to escalate treatment dose by switching to concurrent chemo-radiotherapy in an attempt to improve outcomes. This was the conclusion of a phase …180519 van Loon AJO INTERVIEW Production MASTER

    Image-Guided Radiotherapy: Positioning Errors Affect Overall Survival

    Play Episode Listen Later May 18, 2018 8:00


    BARCELONA—The accuracy of radiation targeting using image-guided radiotherapy (IGRT) was significantly associated with overall survival in a study of a large cohort of patients treated with IGRT for their lung and esophageal cancers. reported at the 2018 European Society For …Corinne Johnson AJO Production MASTER

    Breast Lumps Between Mammography Visits Signal High Risk

    Play Episode Listen Later Apr 19, 2018 0:06


    BARCELONA—Women who develop breast symptoms—especially lumps—between regular mammography screening examinations are up to four times more likely to have a diagnosis of breast cancer soon after than women who do not have symptoms according to findings of a massive study …Deependra Singh AUDIO JOURNAL OF ONCOLOGY

    Ribociclib Aids First-Line Endocrine Therapy in Premenopausal Advanced Breast Cancer

    Play Episode Listen Later Apr 18, 2018 8:00


    BARCELONA—More pre-menopausal women who have estrogen receptor (ER) positive advanced breast cancer could be spared chemotherapy—according to latest findings from the MONALEESA-7 double-blind randomized phase 3 trial in which either placebo (PBO) or the cyclin-dependent kinase (CDK) 4/6 inhibitor ribociclib …Nadia Harbeck with Emiel Rutgers AJO PRODUCTION MASTER

    Reassurance on Ductal Carcinoma in Situ (DCIS) Treatment De-Escalation

    Play Episode Listen Later Apr 17, 2018 0:06


    BARCELONA—A multicenter nationwide Italian study of patients with ductal carcinoma in situ (DCIS) treated with breast conservative surgery (BCS) and whole breast radiotherapy (RT) has updated risk criteria to help women opt for gentler treatments and avoid toxicities from overtreatment.…Icro Meattini AJO PRODUCTION MASTER

    Breast Cancer: Combined Risk Assessment Prompts Treatment De-Escalation

    Play Episode Listen Later Apr 16, 2018 0:12


    BARCELONA—Not only was breast conserving therapy safer than mastectomy for most low-risk patients in the large randomized EORTC 10041/BIG 03-04 MINDACT trial reported at the 2018 European Breast Cancer Conference but also many patients could be advised to avoid chemotherapy …Emiel Rutgers AJO PRODUCTION MASTER

    Double Mastectomy: No Survival Gain for BRCA2 Mutation Carriers—AUDIO JOURNAL OF ONCOLOGY

    Play Episode Listen Later Mar 30, 2018 5:00


    BARCELONA—Healthy women with BRCA1 mutations who opted for bilateral prophylactic mastectomy had their lives prolonged in comparison with similar women who did not. But in healthy women with the BRCA2 mutation the procedure did not improve overall survival even though …

    Polygenic Risk Scores Could Help Predict Second Primary Breast Cancers—AUDIO JOURNAL OF ONCOLOGY

    Play Episode Listen Later Mar 28, 2018 0:04


    BARCELONA—Patients treated for BRCA-associated breast cancers could be given more accurate estimates of the risk for developing second primaries of the contralateral breast by combining polygenic risk scores (PRS) with standard risk factors if study findings reported at the 2018 …Alexandra van den Broek INTERVIEW

    Randomized Study Confirms Rivaroxaban Oral Alternative For Cancer Thromboembolism

    Play Episode Listen Later Feb 5, 2018 15:00


    ATLANTA—Six months follow up of the Select-D randomized open label multicenter pilot study with 406 patients has confirmed that therapy with the direct oral anticoagulant (DOAC) rivaroxaban was a safe and effective alternative strategy to standard treatment with the low …

    Rivaroxaban Confirmed as Oral Alternative For Cancer Thromboembolism

    Play Episode Listen Later Feb 5, 2018 15:00


    ATLANTA—Six months follow up of the Select-D randomized open label multicenter pilot study with 406 patients has confirmed that therapy with the direct oral anticoagulant (DOAC) rivaroxaban was a safe and effective alternative strategy to standard treatment with the low …180131 Annie Young INTERVIEW PRODUCTION MASTER

    Oral Anticoagulant Edoxaban Alternative for Cancer-Related Thromboembolism

    Play Episode Listen Later Jan 26, 2018 10:00


    ATLANTA— In patients with a variety of cancers oral therapy with edoxaban—a direct oral anticoagulant (DOAC)—was just as effective and safe in terms of the risks of recurrent venous thromboembolism (VTE) and bleeding as injections with the low molecular weight …GARY RASKOB Mono INTERVIEW Productdion MASTER

    Venetoclax Pro-Apoptotic Therapy Benefits Older Patients with Acute Myeloid Leukemia

    Play Episode Listen Later Jan 19, 2018 5:00


    ATLANTA—Adding anti-BCL-2 therapy with the small-molecule drug venetoclax (VEN) to standard low-dose cytarabine (LDAC) chemotherapy tripled response rates over historical comparators and extended survival in older patients with acute myeloid leukemia (AML) who were ineligible for intensification of their chemotherapy …Andrew Wei INTEVIEW PRODUCTION MASTER

    Cabozantinib Better for VEGF Resistant Metastatic Renal Cell Carcinoma

    Play Episode Listen Later Apr 20, 2017 0:06


      MILAN, Italy—The first choice of therapy for patients with metastatic kidney cancer who have failed VEGF therapy has changed according to experts at the 2016 European Multidisciplinary Meeting on Urological Cancers (EMUC) who assessed phase 3 study data on …Thomas Powles 1 EMUC PRODUCTION Master

    Which High-Risk Prostate Cancers Need Multimodality Treatment?

    Play Episode Listen Later Apr 18, 2017 0:14


    MILAN, Italy—Patients with node-positive prostate cancer being treated with prostatectomy could derive benefit from early multimodality therapy combining androgen deprivation therapy (ADT) with radiotherapy (RT)—on top of surgery—if they have pathological features indicating high risk, according to findings reported at …Karim Touijer EMUC AJO PRODUCTION Master

    Women With DCIS Live Longer Than General Population

    Play Episode Listen Later Mar 12, 2017 5:00


    Audio Journal of Oncology AMSTERDAM—Women diagnosed with ductal carcinoma in situ (DCIS) of the breast were found to live longer than women in the general population according to a study from the Netherlands reported at the 2017 European Cancer Congress …Elshof INTERVIEW Production MASTER

    First-Line Pembrolizumab Boosts Survival in PD-L1-Positive Advanced Lung Cancer

    Play Episode Listen Later Jan 2, 2017 11:00


    Audio Journal of Oncology, January 2, 2017 COPENHAGEN—Patients with metastatic non-small cell lung cancers (NSCLC) expressing the programmed cell-death ligand 1 (PD-L1) protein responded better to initial treatment with the anti-PD-L1 immunotherapy pembrolizumab—and lived longer with fewer toxicities—than to standard …161209 Audio Journal of Oncology RECK PRODUCTION MASTER

    Second-Generation ALK Inhibitor = Longer PFS in ALK+ Lung Cancer After Crizotinib

    Play Episode Listen Later Dec 8, 2016 8:52


    COPENHAGEN—Longer progression free survival (PFS) was achieved in patients with ALK-rearranged non-small cell lung cancer (NSCLC) previously treated with crizotinib randomised to treatment with the second generation anaplastic lymphoma kinase (ALK) inhibitor ceritinib rather than chemotherapy in the phase 3 …161207-esmo-giorgio-scagliotti-ajo-production-master

    PD-L1 Checkpoint Inhibitor Immunotherapy Boosts Survival in Lung Cancer

    Play Episode Listen Later Dec 5, 2016 10:30


    The Audio Journal of Oncology Reporting from the 2016 Congress of the European Society of Medical Oncology COPENHAGEN—The anti-PD-L1 (programmed cell death ligand-1) immunotherapy agent atezolizumab extended overall survival when compared head-to-head with docetaxel among patients with previously-treated non-small cell …161205-ajo-fabrice-barlesi-esmo-production-master-6-3m-10-30secs

    Lung Cancer—First-Line Checkpoint Inhibitor Combination Benefit

    Play Episode Listen Later Nov 23, 2016 11:00


    COPENAGEN—Adding the PD-1 (programmed cell death protein 1) antibody pembrolizumab to standard first-line chemotherapy with carboplatin and pemetrexed for previously-untreated patients with advanced non-squamous non-small-cell lung cancer (NSCLC) and good performance status significantly improved objective response rate (ORR) and progression-free …161123-ajo-esmo-corey-langer-production-master

    Early Lung Cancer Responds to Preoperative Nivolumab

    Play Episode Listen Later Nov 17, 2016 9:00


    COPENHAGEN—In a phase I study reported at the 2016 congress of the European Society for Medical Oncology (ESMO) six out of 15 patients with resectable early non-small cell lung cancer had “major pathological regression” to neo-adjuvant immunotherapy with nivolumab—the anti-PD1 …161116-ajo-esmo-forde-and-baas-production-master

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