Podcasts about TPS

Pinal County Sheriff Ross Teeple joins the show to discuss his bold leadership, the high-stakes Netflix series "Unlocked: A Jail Experiment" Season 2, and life inside Arizona's corrections system. Fresh off taking office, Sheriff Teeple shares how he was "strong-armed" (old friends) by predecessor Sheriff Mark Lamb into filming a groundbreaking re-entry program that unlocked jail cells, shifted to indirect supervision, and empowered inmates to self-govern—aiming to build responsibility, reduce recidivism, and break cycles of crime. Hear raw stories from his career: his first high-speed pursuit gone wrong, a terrifying hand-to-hand fight during an arrest, heartbreaking search-and-rescue recoveries (including a tragic plane crash in the Superstition Mountains), bizarre and intense calls, and a heartwarming success saving a young woman from a predatory relationship. Sheriff Teeple opens up about border security challenges near the Tohono O'odham Nation (where 80% of U.S. fentanyl crosses), cartel threats on American soil, drone smuggling risks, staffing shortages, pay raises for detention officers, and advice for new law enforcement recruits: put down the phone, build real-world communication skills, and seek face-to-face conflict resolution. Unlocked: A Jail Experiment  Season 2 now on Netlfix - https://www.netflix.com/title/81476420 Follow Sheriff Teeple on Instagram @teepleforthepeople Pinal County Sheriff's Office on Youtube   @PinalCountySheriffsOffice   Contact Steve - steve@thingspolicesee.com Support the TPS show by joining the Patreon community today! https://www.patreon.com/user?u=27353055 Sergeant Steve Youtube Channel https://www.youtube.com/@UCuobtuGxJny9V5lX5a1ieuw

This month we welcome a very special friend of mine, the great dane himself... Freddy Konfeddy. Me and Freddy have shared so many incredible moments in real life together, attended some amazing events and span a whole bunch of mixes together. So this show was well overdue. Freddy's catalog of music is quite easily some of the best mixed in the game, incredibly euphoric while hitting you in the chest plate. The way he's evolved in the sound has been stunning to watch and wonderful on the ears. When I heard his guest mix, I immediately messaged him and said it was making me feel like I was on drugs. Everything from OG nostalgia to wavy pure euphoria, I could have been happier hearing it and then being able to present it to you all like this. What a blessing. Also as you'll hear in the interview, Freddy is very near completion of his heavily anticipated Silent Hill tape. We are very excited to be releasing it via the TPS record label. Release date TBA. I am overjoyed with how 2026 has started for TPS. It's been a grind getting the work bashed out but the sound has been immaculate so far and these interviews have been so nice to take part in. I don't want to give away next month's guest, but as I said in the show it's going to be a dirt special. I am working on another well crafter blend of my favourite dirt classics and we call upon one of the French kings on the sound to supply a guest mix & interview. As always, thank you so much for locking in & supporting TPS, I hope these sessions make you feel as much as they do me when you listen back. And lastly a massive shout out to Paul at Badradio for airing the shows. Stay blessed Discover - Freddy Konfeddy - Soundcloud - @freddykonfeddy Instagram - instagram.com/realfreddykonfeddy.mp3 Teddy Colour / The Phonk Show - Instagram - instagram.com/teddy_colour instagram.com/thephonkshow/ YouTube - @the_phonk_show Badradio - https://badradio.nz Soundcloud - @badradionz Instagram - instagram.com/badradio_ YouTube - @badradio TEDDY COLOUR TRACKLIST - 01. Spaced - Playaz Ball 02. Roland Jones - Smack w/ Soudiere 03. Soudiere - My Hood 04. Roland Jones - Welcome To London 05. Aseri - No Cappin' w/ Mythic 06. Amatsu-Mikaboshi - Honey Count 07. Jason Rich - New Beginnings 08. Roland Jones - Kickin' Pimpin (LIL GIN) 09. Soudiere & Roland Jones - Underground 10. Roland Jones - Dangerous w/ Soudiere 11. Spaced - All Hustle 12. Roland Jones - Ez Come Ez Go 13. Evil - Make A Mood 14. Roland Jones - Leaning On The Curb Sippin Syrup 15. North Posse - Never Trust Em 16. Evil - Intro 17. TheAdult & Backwhen - Need That When 18. Haku - Diamonds 19. Deeboe - Smoked Out 20. Jason Rich - Stick Up 21. Evil - We Don't Play 22. Soudiere - Cocaine & Cadillacs 23. Spaced - Cutthroat 24. Myrror - Track 03 25. Myrror - Track 04 FREDDY KONFEDDY TRACKLIST TBC

I recorded this episode live in Hong Kong with Wish Wu, Co-Founder and CEO of Pharos Network.We dive deep into what it really takes to build next-generation blockchain infrastructure.Pharos is an EVM-compatible Layer 1 hitting 20,000 TPS on testnet. But speed is not the real story. The real story is their focus on connecting Web2 and Web3. Not just users. But capital. Assets. Institutions.Wish shares his journey from building AntChain at Ant Group to launching Pharos. We talk about tokenizing real-world assets, institutional adoption, product-market fit, and why new Layer 1s must stop copying Ethereum.If you're a founder building in Web3, this episode is essential listening.Key LearningsWhy Hong Kong is regaining momentum as a crypto hub.What Pharos Network is building and why 20K TPS matters.Wish's background at Ant Group and building AntChain at scale.Tokenizing new energy assets and institutional funds.Why most new Layer 1s fail without product-market fit.The rise of purpose-built chains and niche-focused infrastructure.Why speculative crypto alone cannot sustain adoption.The vision for Pharos over the next five years.Launching a VC fund and incubator to grow the ecosystem.Fundraising advice: Stop copying. Find real product-market fit.Connecthttps://www.linkedin.com/in/wishlonger/https://www.pharos.xyz/https://www.linkedin.com/company/pharosnetwork/https://x.com/pharos_network DisclaimerNothing mentioned in this podcast is investment advice and please do your own research.It would mean a lot if you can leave a review of this podcast on Apple Podcasts or Spotify and share this podcast with a friend.Be a guest on the podcast or contact us - https://www.web3pod.xyz/

Dr. Lakshmi Rajdev and Dr. Manish Shah join the podcast to discuss the updated guideline on immunotherapy and targeted therapy in unresectable locally advanced, advanced, or metastatic gastroesophageal cancer. They share first-line and subsequent-line recommendations for both gastroesophageal adenocarcinoma and esophageal squamous cell carcinoma based on actionable biomarkers including PD-L1 expression, MMR and/or MSI, CLDN18.2 expression, and HER2 status. They note the importance of the algorithms and tables in the guidelines that provide visual illustrations and quick reference guides of the evidence-based recommendations. They also comment on ongoing and recently presented trials that may impact future guidelines in this space. Read the full guideline, "Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Guideline Update" at www.asco.org/gastrointestinal-cancer-guidelines" TRANSCRIPT This guideline, clinical tools and resources are available at www.asco.org/gastrointestinal-cancer-guidelines. Read the full text of the guideline and review authors' disclosures of potential conflicts of interest in the Journal of Clinical Oncology,  https://ascopubs.org/doi/10.1200/JCO-25-02958      Timestamps ·       00:00 – 02:15 Introduction and Overview ·       02:16 - 08:20 First-line treatment for patients with pMMR/MSS, HER2-negative gastroesophageal adenocarcinoma ·       08:21 –10:29 First-line treatment for patients with pMMR/MSS, HER2-positive gastroesophageal adenocarcinoma ·       10:30 – 14:39 First-line treatment for patients with dMMR/MSI-H, gastroesophageal adenocarcinoma ·       14:40 – 18:03 First-line treatment for ESCC ·       18:04 – 22:04 Second- and third-line therapy for gastroesophageal adenocarcinoma and ESCC ·       22:05 – 24:38 Importance of guideline ·       24:39 – 27:45 Outstanding questions and future research   Brittany Harvey: Hello and welcome to the ASCO Guidelines podcast, one of ASCO's podcasts delivering timely information to keep you up to date on the latest changes, challenges, and advances in oncology. You can find all the shows, including this one, at asco.org/podcasts.   My name is Brittany Harvey, and today I am interviewing Dr. Lakshmi Rajdev from the Icahn School of Medicine at Mount Sinai and Dr. Manish Shah from Weill Cornell Medicine, co-chairs on "Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Guideline Update." Thank you for being here today, Dr. Rajdev and Dr. Shah. Dr. Lakshmi Rajdev: Thank you. Dr. Manish Shah: Thank you for having us. It is wonderful. Brittany Harvey: And then just before we discuss this guideline, I would like to note that ASCO takes great care in the development of its guidelines and ensuring that the ASCO conflict of interest policy is followed for each guideline. The disclosures of potential conflicts of interest for the guideline panel, including Dr. Rajdev and Dr. Shah, who have joined us here today, are available online with the publication of the guideline in the Journal of Clinical Oncology, which is linked in the show notes. So then to dive into what we are here today to talk about, Dr. Shah, I would like to start first with what prompted the update to this guideline, which was previously published in 2023, and what is the scope of this updated guideline? Dr. Manish Shah: Yes, terrific. So even in the last few years, the pace of drug development in gastroesophageal cancers has just been astounding. So, what prompted this guideline is actually the practice-changing results for a new biomarker, CLDN18.2 hat was based on the GLOW and SPOTLIGHT studies, as well as a practice-changing study in HER2-positive disease where we added pembrolizumab to trastuzumab and chemotherapy for tumors that are HER2-positive and PD-L1 CPS 1 or greater. And then there were also new studies and new approvals in esophageal squamous cell cancer that you will hear about as well. So there were several studies, overall more than 5,000 patients were reported on, and that led to several new therapies, new indications, and it really necessitated this guideline. Brittany Harvey: Excellent. It is great to hear about all of these exciting updates in this space. So then to next review the key recommendations of this guideline by clinical question that the expert panel addressed. So, Dr. Rajdev, what is the recommended first-line treatment for patients with proficient mismatch repair, microsatellite stable, HER2-negative gastroesophageal adenocarcinoma? Dr. Lakshmi Rajdev: Thank you for that question. So historically, we have sort of used fluoropyrimidine and platinum doublets, which yielded a survival of about one year. More recently, immunotherapy and targeted therapy options have improved outcomes in patients with advanced esophageal and gastric adenocarcinoma, as well as squamous cell carcinoma. Patients with gastric and GE junction adenocarcinoma have a high rate of actionable alterations, so it is imperative that physicians test the following biomarkers upfront so that it can help guide therapy. The markers recommended by the ASCO panel are HER2, MMR or MSI, CLDN18.2, and PD-L1. And also, it was recommended to use NGS if feasible in this patient population. HER2, as we know, is expressed in about 15% to 25% of patients; PD-L1 expression occurs in about 80% of patients; MSI-high, deficient MMR is present in about 5% to 8% of patients; and CLDN18.2 expression is present in about 40% of patients. There is, of course, biomarker overlap. About 13% to 22% of CLDN18.2 patients are also PD-L1 positive. For patients with pMMR or microsatellite stable HER2-negative disease with PD-L1 expression greater than 1 and absence of CLDN18.2, the panel recommended a first-line therapy with fluoropyrimidine and platinum-based therapy in combination with immunotherapy. These recommendations stem from large phase 3 trials, and the agents approved in the United States are pembrolizumab, nivolumab, and tislelizumab. It has been shown that immunotherapy benefit is greater in patients with higher PD-L1 expression, and it is not possible to comment on the individual PD-L1 cutoff scores and sort of identify the optimal PD-L1 cutoff score that sort of balances benefits and harms. But what is recommended is that immunotherapy-based treatments can be offered in patients with a CPS score of greater than 1. With regard to the choice of immunotherapy agents, that is pembrolizumab, nivolumab, or tislelizumab, these agents are considered to have similar efficacy, and the selection of an agent could be based on dosing schedule, cost considerations, toxicity, and the method of administration. Typically, clinicians should avoid withholding the start of chemotherapy while awaiting biomarker testing, depending on the clinical scenario. Now, for patients with pMMR microsatellite stable disease that is HER2-negative with PD-L1 expression less than 1 and positive CLDN18.2 expression, zolbetuximab-based treatments or in combination with chemotherapy is recommended, and this is based on two global phase III randomized controlled trials, the GLOW and the SPOTLIGHT. And across both studies, the hazard ratio for the overall survival was 0.78, and similarly, there was also an improvement in progression-free survival favoring the zolbetuximab group compared to the chemotherapy group alone. An important note is that nausea, vomiting is commonly associated with zolbetuximab-based treatments, and the panel recommended prophylactic antiemetics, adjusting zolbetuximab infusion rates, pausing infusion temporarily, using non-prophylactic antiemetics, and hydration intravenously prior to discontinuation of zolbetuximab-based chemotherapy. So effective handling of the GI-related symptoms with zolbetuximab is recommended prior to discontinuation of therapy. Now, for patients with pMMR microsatellite stable HER2-negative gastric, GE junction adenocarcinoma with PD-L1 expression greater than 1 and CLDN18.2 positivity, the ones with the dual expression with CLDN18.2 as well as PD-L1 chemotherapy, the choice of therapy can be based on the degree of PD-L1 expression, the toxicity profile, the burden of symptoms, and the anticipated improvement in symptoms associated with response to treatment, the patient comorbidities, the prior medical and treatment history. So this decision needs to be made on a case-by-case basis, and these are some of the factors that we suggested that could potentially influence the choice of therapy. For patients with pMMR microsatellite stable disease that is HER2-negative and a PD-L1 expression less than 1 and an absence of CLDN18.2 expression, first-line therapy with fluoropyrimidine and platinum-based chemotherapy is recommended. So you can see we have segmented out patients based on PD-L1 expression, pMMR and microsatellite stable disease expression, and also based on CLDN expression. Brittany Harvey: Absolutely. And that first point you noted, I think is really important, that biomarker testing is really critical for treatment decision-making in this space. So then the next subgroup of patients that the panel looked at, Dr. Shah, what first-line therapy is recommended for patients with proficient mismatch repair, microsatellite stable, HER2-positive gastroesophageal adenocarcinoma? Dr. Manish Shah: So this was an update from a few years ago. So we have known for 15 years now that if you are HER2-positive, you should get trastuzumab plus chemotherapy. That was based on the ToGA trial. And the update now is based on a trial called KEYNOTE-811, where it examined the addition of pembrolizumab to trastuzumab and chemotherapy versus trastuzumab and chemotherapy, and there was a progression-free and overall survival benefit. And again, here, the biomarkers are important. If your CPS PD-L1 is less than 1, we would not recommend Pembrolizumab in that setting, so you would still get trastuzumab and chemotherapy. But if it is 1 or greater, the PD-L1 CPS score, then we do recommend pembrolizumab unless there is a contraindication to immunotherapy. The take-home message really is from the onset of diagnosis, please check your biomarkers. And I will just, it is worth repeating, it is important to check your PD-L1 status, HER2 status, mismatch repair status, and CLDN18.2 status. And then the optimal therapy, and it is outlined in the publication, is really biomarker-driven. We know that if we are able to hit the target that is overexpressed, we are going to have a better outcome. And Dr. Rajdev did mention where there is overlap, there can be a lack of data, and that is where we are with both PD-L1 positive and CLDN positive. Here we do have data in HER2-positive cases where if you are both HER2-positive and PD-L1 positive, you would combine trastuzumab and pembrolizumab for the best outcomes. Brittany Harvey: Understood. I really appreciate you detailing what is most important for each individual biomarker combination that patients may have. So then following that, Dr. Rajdev, what does the expert panel recommend for first-line treatment for patients with esophageal squamous cell carcinoma that is not amenable to definitive chemoradiation? Dr. Lakshmi Rajdev: There are three phase III randomized clinical trials that have influenced practice in patients with esophageal squamous cell carcinoma examining the benefit of immunotherapy in this patient population. The RATIONALE-306 was a randomized trial of tislelizumab plus chemotherapy with platinum and fluoropyrimidine or paclitaxel versus placebo with chemotherapy. And then you have the KEYNOTE-590, which compared pembrolizumab plus chemotherapy versus chemotherapy alone. And then you have CheckMate-648, which included comparisons of nivolumab plus chemotherapy versus nivolumab plus ipilimumab or chemotherapy. And the primary endpoints for these studies were overall survival, and they did look at subgroups with PD-L1 expression. They used TPS score greater than 1% in CheckMate-648 and PD-L1 CPS greater than 10 in KEYNOTE-590. The bottom line is that the overall hazard ratio for overall survival across this patient population was 0.72. So clearly, there is benefit in patients that express PD-L1 CPS greater than 1 for benefit for the addition of immunotherapy. Now, the benefit again in patients with a PD-L1 expression less than 1 remains limited, and so the panel has made a recommendation for using immunotherapy in combination with platinum-based chemotherapy in patients with a PD-L1 greater than 1. Again, we know that it is hard to make recommendations on what PD-L1 cutoffs are recommended in this patient population, meaning that should it be limited to patients with a PD-L1 of 1 to 4 or greater than 10? I think that the general consensus that has been gleaned from the data is that the higher the PD-L1 expression, the greater the benefit. I do want to comment on another option that is available in patients with squamous cell carcinoma compared to adenocarcinoma, and that is the combination of nivolumab and ipilimumab. Now, in CheckMate-648, nivolumab with ipilimumab was also recommended as a treatment option in patients that have a PD-L1 score of greater than 1. There was a survival benefit demonstrated with this combination compared to chemotherapy alone. And an important observation in this study is that, although there was a slightly increased rate in early death, but there was really no significant difference in PFS and OS compared to chemotherapy alone. Importantly, the treatment appeared to be pretty well tolerated by the study population. There was a notable difference in the objective response rate, which was 35% in the nivolumab plus ipilimumab group compared to patients receiving nivolumab and chemotherapy, where it was 53%. So superiority is, so the importance of chemotherapy in patients with esophageal squamous cell carcinoma is to be noted. However, there is no difference in overall survival and progression-free survival when using the combination of nivolumab and ipilimumab, and thus it affords a chemotherapy-free option for this patient population with esophageal squamous cell carcinoma and a CPS with a score of greater than 1. Brittany Harvey: Understood. I appreciate you reviewing the evidence underpinning those recommendations as well. So then the next patient population that the guideline panel addressed, what first-line therapy is recommended for patients with deficient mismatch repair, microsatellite instability-high, gastroesophageal adenocarcinoma or esophageal squamous cell carcinoma? Dr. Lakshmi Rajdev: The rate of MSI-high expression is about 3% to 7% across different studies. Now, the KEYNOTE-158 was a tumor-agnostic study in patients with non-colorectal cancers, and again, the problem with the MSI-high population, given that it is so rare, the numbers in the individual studies are fairly small. But consistent outcomes do emerge, indicating high response to immunotherapy. So in KEYNOTE-158, a response rate of about 46% was noted. The number of patients was small, it was about 24. In CheckMate-649, which is a study of chemotherapy plus or minus nivolumab in patients with advanced gastric adenocarcinoma, there was again a very small number of patients, and patients that were MSI-high or deficient MMR did experience substantial benefits with the addition of immunotherapy, with hazard ratios in the order of about 0.38. In KEYNOTE-062, again, it was a very small number of patients, again about 6% or so, and similar to CheckMate-649, a substantial benefit was noted in combination with chemotherapy, but also there were benefits noted with pembrolizumab alone. The RATIONALE-305 again was a study of tislelizumab in combination with chemotherapy and similarly showed benefits to the combination of chemotherapy plus immunotherapy in this patient population. I think that we are all aware of the dramatic benefits of immunotherapy in this particular subset of patients, deficient MMR MSI-high, and also we have seen in CheckMate-649 they did have a subset of patients that received nivolumab and ipilimumab. And in this patient population, they noted unstratified hazard ratio of 0.28. So I think that the overall consensus is that immunotherapy is a very important treatment modality in patients with deficient MMR MSI-high disease, given that a lot of the trials in gastroesophageal adenocarcinoma have utilized chemotherapy-based options, that is certainly a recommendation of the panel to use chemotherapy in combination with immunotherapy. However, on a case-by-case basis, the panel recommended immunotherapy alone as well, and given the high response rates noted in trials across different diseases as well as noted in this disease as well. Brittany Harvey: Certainly. And I appreciate you both for reviewing these first-line recommendations. So moving to later lines of therapy, Dr. Rajdev, what recommendations did the expert panel make for second or third-line therapy for gastroesophageal adenocarcinoma and esophageal squamous cell carcinoma? Dr. Lakshmi Rajdev: So, I think that the RAINBOW trial that investigated the utility of the addition of ramucirumab as second-line therapy has been around since 2014, and those results have led to the addition of ramucirumab to taxane-based therapy in the second-line setting. Based on the utilization of oxaliplatin and platinum-based therapy in the front-line setting, there may be patients that have an underlying neuropathy, and so we wanted to really include treatment options for this patient population so that an agent that is less neurotoxic could also be recommended in combination with ramucirumab. The RAMIRIS trial is one such trial where ramucirumab was combined with FOLFIRI, and it demonstrated benefit in combination with ramucirumab. So we have listed that as a potential treatment option for patients in the second-line setting who may have an underlying neuropathy or even for whatever reason that based on the toxicity profile, that needs to be the preferred option by a physician, that recommendation is new from the older guidelines that we have. With regard to the utility of PD-1 inhibitors, there really has been no benefit noted in the second-line setting with regard to overall survival or progression-free survival, so no recommendation is made for that option. I think an important study that has been recently presented is the DESTINY-Gastric04 trial, which really has been practice-changing and has led to the recommendation for trastuzumab deruxtecan in patients that have HER2-positive metastatic gastric or GE junction adenocarcinoma. Now, this is a phase III trial in patients who retained HER2-positive disease after progressing on front-line trastuzumab-based treatments, and the comparator for this trial was trastuzumab deruxtecan versus ramucirumab plus paclitaxel. There was significant improvement and progression-free survival in patients that received trastuzumab deruxtecan. The patients that were excluded from the trial are patients that have pulmonary problems, interstitial lung disease; that is one of the toxicities of this particular agent, and close monitoring and prompt initiation of therapy such as glucocorticoid treatment in patients who develop this toxicity was also highlighted by the panel. So to summarize, the new guidelines highlight the possibility of FOLFIRI plus ramucirumab as a second-line option and then trastuzumab deruxtecan as a later-line option in patients that still retain HER2 expression. And that is very important because the trial did retest patients whether they expressed HER2. As we know, in a substantial number of patients, there is downregulation of HER2, and there is emerging data that the benefit for subsequent HER2-directed therapies is best noted in patients that still retain HER2 expression. Brittany Harvey: Great. So as our listeners have heard, there are many recommendations and new treatment options for advanced gastroesophageal cancer. Dr. Shah, earlier you highlighted the importance of biomarker testing, but I would like to hear in your view, what is the importance of this guideline and how will it impact both clinicians and patients with gastroesophageal carcinoma? Dr. Manish Shah: So as we have discussed throughout this podcast, the treatment for gastroesophageal cancer, both adenocarcinoma and squamous cell cancer, is increasingly complex, increasingly biomarker-driven. And I think the value of the guideline is to place all of that into context. So it provides the data for why certain biomarkers are important, what therapies should be indicated. Not only that, but if you are able to review the guideline, it provides the details of each of these studies and summarizes them in a meta-analysis fashion to sort of give you the context, because sometimes the individual studies can be maybe a little bit discordant or confusing and the guideline attempts to harmonize all that. And then also, I think the tables are very, very interesting because they give you actual numbers in terms of how many patients over a thousand would this benefit or how many patients over a thousand would this cause harm in terms of nausea, vomiting, or other things like that. So it gives you context for helping clinicians and patients weigh the potential benefits of the novel treatment strategies against the potential adverse events. And then finally, the guideline does also provide an algorithm that you are able to follow based on the biomarkers, and those are in figures 4 and 5. So I think overall, it is a very comprehensive guideline. It intends to make more manageable a very complex subject, and you know, I really encourage our listeners to review it after listening to the podcast. Dr. Lakshmi Rajdev: If I can add to that, I think that what is also really good about the guidelines is there are quick summaries. So if someone is busy in the clinic, of course, there is the opportunity to review the data supporting the guidelines in great depth in the manuscript, but what is also really good is that there are good summaries. In the event that you are very busy, you can easily identify what the recommendations should be for that particular patient based on these summaries. Brittany Harvey: Absolutely. Listeners are encouraged to review the full guideline, including those tables and figures that may be more helpful when they are looking for something quick to look at in the clinic as well. So, as you both mentioned, there have been a number of recent practice-changing trials in this area. So I imagine there is still a lot of ongoing research as well. So Dr. Shah, what are the outstanding questions regarding treatment options for patients with locally advanced unresectable, advanced, or metastatic gastroesophageal carcinoma? Dr. Manish Shah: I think we touched upon it a little bit. The guidelines are based on the data available, and they are primarily examining one novel therapy with chemotherapy in a specific biomarker population. But as you know, the biomarkers are not either/or; you are not either CLDN18.2 positive or PD-L1 positive. A portion of patients could have dual biomarkers, and you know, I think that we are generating data on how to manage those patients. At the recent GI Symposium in January this year, the ILUSTRO trial was presented by Dr. Shitara, which looked at combining zolbetuximab and chemotherapy with immunotherapy for dual-positive biomarkers, and that is leading to a phase III study that has begun to enroll. So unanswered questions are: how do we manage dual-positive biomarkers? The other thing that was mentioned is that the current data for mismatch repair deficiency involve chemotherapy plus immunotherapy. Only squamous cell cancer is there a study with a positive non-chemotherapy kind of backbone, that is CheckMate-648 that Dr. Rajdev mentioned. As we move forward, it will be good to get data on non-chemotherapy options in certain biomarker-positive populations. And then finally, another update, which is likely to be practice-changing, is the HERIZON-GEA-01 study that looked at zanidatamab, which is another biparatopic antibody that targets HER2, and that is likely to change practice. And as that data gets published, we may look to even do a rapid update for the current immunotherapy and targeted therapy guideline that is just being published. Dr. Lakshmi Rajdev: So, if I can add to that, there are numerous ADCs that look very interesting. There are bispecific antibodies; in fact, the zanidatamab is a bispecific antibody showing improved activity in patients with HER2-positive disease. So I think there are studies from Asia looking at CLDN CAR T-based therapies. So, I think that there are a lot of novel agents and a lot of excitement in the field. We know that the bemarituzumab study, unfortunately, the FGFR2 inhibitor failed to demonstrate any benefit, but I think that there are other agents that are being explored, so there are newer targets, newer agents, ADCs, bispecifics that could potentially change the field in the future. Brittany Harvey: Yes, we will look forward to the data to address these unanswered questions and new agents and inform future guideline updates. So, I would like to thank you both for all of your work to review the evidence here and update this important guideline, and for your time today, Dr. Rajdev and Dr. Shah. Dr. Lakshmi Rajdev: Thank you. Dr. Manish Shah: Thank you. Brittany Harvey: And finally, thank you to all of our listeners for tuning in to the ASCO Guidelines podcast. To read the full guideline, go to www.asco.org/gastrointestinal-cancer-guidelines. You can also find many of our guidelines and interactive resources in the free ASCO Guidelines app, which is available in the Apple App Store or the Google Play Store. If you have enjoyed what you have heard today, please rate and review the podcast and be sure to subscribe so you never miss an episode. The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.

Discover the raw truth about traumatic brain injury (TBI) and PTSD in law enforcement from retired officer Jeff Casselman, who served 27 years in the military and at Lorain Ohio PD. After multiple concussions from cruiser accidents, bar fights, and on-duty violence, Jeff faced memory loss, rage blackouts, seizures, and three failed marriages before a diagnosis changed everything. He shares powerful stories: brutal fights, bizarre calls (like a grim reaper walking a goat), heartwarming redemption with a former addict he helped save, and the "Wild West" days of policing. Jeff founded the Sentinel Neuro Awareness Institute and authored Survival Guide to educate officers, departments, and families on recognizing cumulative brain damage early—before it destroys careers, relationships, or lives. Topics include: firearm concussion risks, hyperactive startle response, adult-onset ADD from head trauma, medications like lamotrigine (Lamictal) for impulse control, and why early awareness matters for cops, veterans, and contact-sport athletes. If you're in law enforcement, a first responder, veteran, or love someone who is—this eye-opening interview reveals the hidden neurological toll of the job and how to fight back. Jeff's Book https://a.co/d/09rr36Ge Facebook https://www.facebook.com/share/1FRkgeRM8F/?mibextid=wwXIfr Contact Steve - steve@thingspolicesee.com Support the TPS show by joining the Patreon community today! https://www.patreon.com/user?u=27353055 Sergeant Steve YouTube Channel https://www.youtube.com/@TheSergeantSteve      

Toyota practically wrote the book on continuous improvement. But can the plays that won championships before still win them today? This week, Kevin Austin, Group Vice President, Supply Chain at Toyota North America, tackles one of the hardest leadership challenges: transforming a company built on discipline and proven systems without losing what made it great. In conversation with Zero100 Chief Research Officer Kevin O'Marah (yes, two Kevins), he reveals why TPS is the foundation that makes transformation possible, and what happens when AI meets craftspeople who've spent 30 years building cars.The tension between pride, legacy, and a world that got way more complex (01:20)How to know when digital transformation isn't working (and you're the bottleneck) (03:37)Early missteps and why noble missions beat shiny tools (05:37)Fixing friction from forecasting all the way to customer delivery (08:20)When customers can track a $10 pizza but not a $50,000 vehicle (12:37)How TPS creates a stable backbone for experimentation (15:17)When AI meets craftsmanship: Amplifying 30 years of judgment with technology (17:07)What stays Toyota, what must change, and Kevin's north star (22:24)

MERCH ALERT! Perfect gifts for TPS listeners...Delightful almond-scented soap that contains a full set of dice! You can get yours here: https://fantasy-scents.com/products/total-party-skill-dice-soap-dungeons-bubbles This week's segments: 1. Creating Immersion at the Table 2. Homebrewing "Madien's Veil" 3. Draft to Make a Disney D&D Party (Animation, No Marvel) Support us on Patreon https://www.patreon.com/c/TotalPartySkill/home to get access to PDFs of our homebrew and see uncut video from the podcast! Plus, bonus content exclusive only to patrons! Subscribe for more weekly Dungeons & Dragons content! And follow us on our socials for previous draft videos and to learn more about us: Gabe -- @gabespan (TikTok, Instagram) George -- @dmgeorge_primavera (Instagram, TikTok) Dylan -- @whatcha_mccollum (Instagram) Whitney -- @whitneyavalon (All Socials)

En nuestro show semanal “Tus Derechos”, la abogada Stacy Ehrisman explicó los cambios más recientes en inmigración y respondió preguntas en vivo de nuestra comunidad.Hablamos sobre la terminación del TPS para Honduras, Nepal y Nicaragua, restricciones para ciertos países, Visa U, perdones 601/601A, fianzas, ajustes por matrimonio o hijos ciudadanos, cancelación de deportación y riesgos en casos de asilo.

What's it really like to work as a Peace Officer in Alberta, Canada? In this episode, Steve sits down with Brad Larsen, a veteran CPO who has served since 2014, to break down the major differences between Canadian policing and U.S. policing — from authority levels to training, to why peace officers aren't armed, and how they work alongside the RCMP. Brad shares unfiltered stories from the road, including bizarre bylaw calls, intense foot chases, dangerous encounters, and the time suspects stole his patrol truck during a fight outside a hockey arena. He also talks about animal enforcement, impaired driving laws, provincial authority, and what it's like policing vast rural areas in Alberta. If you're curious about Canadian law enforcement, the Peace Officer Act, or the realities of rural policing, this episode delivers a rare inside look at a profession most people outside Canada have never heard of. Contact Steve - steve@thingspolicesee.com Support the TPS show by joining the Patreon community today! https://www.patreon.com/user?u=27353055 Sergeant Steve -  @TheSergeantSteve   https://www.youtube.com/@UCuobtuGxJny9V5lX5a1ieuw 

Haitians living in the U.S. under Temporary Protected Status (TPS) are once again facing uncertainty. Though a federal judge intervened just a day before the Trump administration was set to end TPS for Haiti, thousands of families are still left not knowing what happens next. Professor Evan Auguste explains the emotional strain of living with the constant fear of losing legal status, and how history, trauma, and racism have shaped the mental health of Haitian immigrants. He also shares his work to help create a culturally rooted healing initiative that brings Haitian traditions into mental health spaces, and what this project can teach psychologists and policymakers alike. For more on this topic: Read his opinion piece in the Haitian Times, How we hold Haiti's diasporic grief Check out his co-authored analysis in NACLA Report, To Save Haitian Lives, Global Health Leaders Call for Solidarity

MERCH ALERT! Perfect gifts for TPS listeners...Delightful almond-scented soap that contains a full set of dice! You can get yours here: https://fantasy-scents.com/products/total-party-skill-dice-soap-dungeons-bubbles This week's segments: 1. Base Class Design 2. Homebrewing "Heartbreak" 3. Draft of Best Base Class Features Support us on Patreon https://www.patreon.com/c/TotalPartySkill/home to get access to PDFs of our homebrew and see uncut video from the podcast! Plus, bonus content exclusive only to patrons! Subscribe for more weekly Dungeons & Dragons content! And follow us on our socials for previous draft videos and to learn more about us: Gabe -- @gabespan (TikTok, Instagram) George -- @dmgeorge_primavera (Instagram, TikTok) Dylan -- @whatcha_mccollum (Instagram) Mike -- @magehandpress (All Socials) / MageHandPress.com / SciFi5e.com

Docket Alerts:Exactly zero grand jurors voted to indict the members of Congress who made a video in November reminding active duty service members of their duty to refuse illegal orders. And Judge Richard Leon told Secretary Hegseth to pound “Horsefeathers!” with his attempt to demote Senator Mark Kelly and dock his naval retirement.The Justice Department hasn't stopped trying to evade senate confirmation for US Attorneys. Hours after judges in New York exercised their legal right to appoint someone competent to run the office, the Trump administration fired him. Subscribers will get a deep dive into AG Bondi's efforts to ONE WEIRD TRICK a “triumvirate” of lawyers into the US Attorney spot.MAIN SHOW:Two hundred federal and state agents descended on a Mexican heritage festival in Idaho in October. They leveraged five arrest warrants for illegal gambling into a massive detention operation to brutalize hundreds of families. Now those families are suing under 42 USC § 1983, alleging a conspiracy between the feds and local law enforcement.In DC, Trump appointee Judge Tim Kelly blocked the administration from taking revenge on inmates whose death sentences were commuted by President Biden by moving them all to Supermax.After the Fifth Circuit's terrible ruling last week allowing for indefinite detention of all non-citizens, district court judges are still finding ways to grant habeas petitions.Back in DC, Judge Ana Reyes barred Secretary Noem from ending temporary protected status for 350,000 Haitians. She also had some frank words about the threats that rain down on judges who rule against the Trump administration – and why they won't succeed.Rodriguez v. Porterhttps://www.courtlistener.com/docket/72256071/rodriguez-v-porter/Taylor v. Trump [Death Row Commutations]https://www.courtlistener.com/docket/71717101/taylor-v-trump/Kelly v. Hegsethhttps://www.courtlistener.com/docket/72131361/kelly-v-hegseth/US v. Naviwala [US Attorney New Jersey]https://www.courtlistener.com/docket/68269162/united-states-v-naviwalaCumbe Lema v. De Anda-Ybarra [Texas Habeas]https://www.courtlistener.com/docket/72210802/cumbe-lema-v-de-anda-ybarra/Hassen v. Noem [Texas Habeas]https://www.courtlistener.com/docket/72143519/hassen-v-noem-secretary-us-department-of-homeland-security/Lesly Miot v. Trump [Haitian TPS]https://www.courtlistener.com/docket/70965949/lesly-miot-v-trump/Show Links:https://www.lawandchaospod.com/BlueSky: @LawAndChaosPodThreads: @LawAndChaosPodTwitter: @LawAndChaosPodSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

En nuestro show semanal “Tus Derechos”, la abogada Stacy Ehrisman de The Ehrisman Law abordó los cambios más recientes en inmigración y respondió preguntas en vivo de nuestra comunidad sobre casos reales y situaciones urgentes.En este programa hablamos sobre:

Step inside the world of frontline policing with retired San Antonio Police Officer Ernie Stevens, co‑author, crisis‑response pioneer, and star of HBO's Ernie & Joe: Crisis Cops. In this powerful interview, Ernie shares raw, unfiltered stories from 30 years on the job — from adrenaline‑pumping pursuits to heartbreaking death notifications, bizarre calls, and the creation of one of the nation's most respected police mental‑health units. Host Steve Gould of Things Police See dives deep into Ernie's early days as a young officer, his most intense and terrifying moments, and the emotional toll that comes with serving a major city like San Antonio. Ernie also opens up about responding to officers in crisis, the evolution of de‑escalation, and what policing really looks like behind the scenes. If you're interested in law enforcement, mental health, crisis intervention, or real‑world police stories told without filters, this episode delivers. Ernie and Scott's Book https://a.co/d/1ZnX4BO Contact Steve - steve@thingspolicesee.com Support the TPS show by joining the Patreon community today! https://www.patreon.com/user?u=27353055 Sergeant Steve -  @TheSergeantSteve   https://www.youtube.com/@TheSergeantSteve

AlabamaAn event involving 1819 News CEO is cancelled over threats and safetyAL House Majority Leader Scott Stadhagen to run for ALGOP ChairmanAn illegal alien is under arrest in Mobile for kidnapping of 3 peopleNew EBT cards from AL Dept of Human Resources are now chip enabledState Sales tax holiday coming for severe weather suppliesMobile pastor, Travis Johnson talks about new book and how he learned to stand up for his faithNationalA federal appeals court rules that DHS can end TPS status for migrantsPresident Trump takes on Canada for courting China and ignoring USFL Congresswoman has plans to send the SAVE Act over to Senate for voteFBI releases the warrant document leading to raid of election hub in GAAZ sheriff has person of interest in custody re: kidnapped Nancy GuthrieFDA has rejected Moderna's review request for new mRNA flu vaccine

Actualmente hay cientos de niños detenidos con sus padres en centros de inmigración, hablamos con una madre detenida con su bebé de solo 2 meses de nacido.El FBI divulgó las imágenes de un posible sospechoso en el secuestro de Nancy Gothrie, la madre de la presentadora Savannah Gothrie.Manuel Ortega, ex agente del FBI y experto, nos explica qué pistas da el video del sospechoso en el secuestro de Nancy Gothrie.Hay dos personas detenidas en relación a la desaparición de la familia Choc en Mobile, Alabama.

I never thought I'd be glued to my screen watching court battles unfold like a high-stakes thriller, but here we are in the thick of President Donald Trump's second term, with legal fights erupting everywhere from federal appeals courts to the steps of the Supreme Court. Just last Friday, a divided panel of the U.S. Court of Appeals for the Fifth Circuit upheld the Trump administration's immigration detention policy, mandating that people arrested in the crackdown stay detained without bond, as reported by Reuters journalist Nate Raymond. It's a win for the White House's tough stance on borders, keeping the momentum from earlier victories.Meanwhile, the Supreme Court is buzzing with Trump-related pleas. On February 6, the U.S. Court of Appeals for the Fourth Circuit, in National Association of Diversity Officers in Higher Education v. Trump, vacated a nationwide injunction blocking two of Trump's executive orders targeting what he calls illegal diversity, equity, and inclusion programs in federal grantees and contractors. Chief Judge Albert Diaz wrote the opinion, remanding it to the District of Maryland and signaling these orders might survive scrutiny, according to Law and the Workplace analysis. Employers, especially government contractors, are on notice—DEI initiatives could face real enforcement heat now.Over in immigration again, the Trump team filed an official appeal notice in a Haitian Temporary Protected Status suit, challenging U.S. District Judge Ana Reyes' February 2 ruling that halted the cancellation of TPS for Haitian immigrants, per The Columbus Dispatch's Bethany Bruner. Government lawyers even asked Reyes to pause her order by noon that day, pushing the case toward the U.S. Court of Appeals for the District of Columbia Circuit and potentially the Supreme Court itself.Redistricting wars rage on too. The Supreme Court recently cleared new maps for Texas and California—Texas gaining five Republican-friendly House seats, California countering with five for Democrats—yet battles like Louisiana v. Callais over race and the Voting Rights Act continue, as detailed by Washington Examiner's Jack Birle. And get this: Trump's lawyers are petitioning the Supreme Court to toss the 2023 E. Jean Carroll civil verdict against him, arguing in their final brief that the president is too busy running the country to fight old allegations, according to USA Today's Maureen Groppe. The justices will conference on it February 20.Don't forget the bigger picture from the Brennan Center: while Trump was convicted in New York City state court in May 2024 for falsifying business records over hush money to adult film actor Stormy Daniels, three criminal cases linger—federal ones in Washington, D.C., for election interference, Fulton County, Georgia, for the same, and Florida over classified documents. Lawfare's litigation tracker counts 298 active challenges to Trump administration actions on national security, plus 14 Supreme Court stays favoring the feds.Even whispers of impeachment surfaced, with ET Now's February 6 livestream claiming the House of Representatives is deciding Trump's fate—though details remain murky amid the chaos. From Venezuelan TPS revocations paused by the Supreme Court despite U.S. District Judge Edward Chen's rulings in San Francisco, to National Guard deployment blocks in Illinois that Trump ultimately pulled back from Chicago and Portland, these shadow docket moves have real-world bite, as SCOTUSblog explains.It's a legal whirlwind, listeners, with Trump fighting on multiple fronts, courts picking sides, and the Supreme Court wielding quiet power that reshapes policies overnight. Stay tuned as these cases collide toward 2026 elections.Thank you for tuning in, listeners. Come back next week for more, and this has been a Quiet Please production. For more, check out Quiet Please Dot A I.Some great Deals https://amzn.to/49SJ3QsFor more check out http://www.quietplease.aiThis content was created in partnership and with the help of Artificial Intelligence AI

Miot, et al. v. Trump, et al., No. 25-cv-02471 (D.D.C. Feb. 2, 2026)TPS for Haiti; pretextual termination of TPS; INA § 242(f); APA vacatur and set aside; APA stay; equal protection; McNary; using public statements in litigation Matter of G-M-I-, 29 I&N Dec. 431 (BIA 2026)reliability and persuasiveness of expert testimony; factual basis for expert opinion; CAT; imprisonment for drugs; China Matter of Yadav, 29 I&N Dec. 438 (BIA 2026)sua sponte reopening based on marriage to a U.S. citizen; equities acquired after removal order Michelin, et al. v. Warden Moshannon Valley Correctional Center, et al., No. 24-2990 (3d Cir. Feb. 2, 2026)EAJA; habeas; sovereign immunity canon; civil action; importance of habeas; unreasonable prolonged detention  Montejo-Gonzalez, et al. v. Bondi, No. 21-304 (9th Cir. Feb. 5, 2026) (en banc)in absentia motion to reopen based on exceptional circumstances; unconscionable result; totality of the circumstances; traffic accidents; motivation to attend hearing Pinilla Perez v. Bondi, No. 23-6363 (2d Cir. Feb. 5, 2026)equitable tolling; reopening; OIL admission that N.Y. Penal Law § 220.39(1) attempted sale of cocaine is not a removable offense; Minter; N.Y. Crim. Proc. § 440.10(1)(k); change of law; reasonable diligence of removed noncitizensKurzban Kurzban Tetzeli and Pratt P.A.Immigration, serious injury, and business lawyers serving clients in Florida, California, and all over the world for over 40 years. Gonzales & Gonzales Immigration BondsP: (833) 409-9200immigrationbond.com  EB-5 Support"EB-5 Support is an ongoing mentorship and resource platform created specifically for immigration attorneys."Contact: info@eb-5support.comWebsite: https://eb-5support.com/Stafi"Remote staffing solutions for businesses of all sizes"Click me!The Pen and SwordClick me!Discount code: ImmigrationReview26 Want to become a patron?Click here to check out our Patreon Page!CONTACT INFORMATION:Email: kgregg@kktplaw.comFacebook: @immigrationreviewInstagram: @immigrationreviewTwitter: @immreviewAbout your hostCase notesRecent criminal-immigration article (p.18)Featured in San Diego VoyagerSupport the show

#189En este episodio, la abogada Barbara Vazquez del bufete de abogados de inmigración, Vazquez & Servi, P.C., contesta preguntas de los oyentes de PA'LANTE MI GENTE! PREGUNTA:¿Con cuanto tiempo de anticipo se pueden hacer las renovaciones de residencia, permiso de trabajo, DACA, TPS, etc.? PREGUNTA:Mi esposo tiene cita en Ciudad Juarez para su tramite de residencia en abril de este año. Pero en diciembre 2025 fue arrestado por DUI y no tiene corte todavía. ¿Qué tenemos que hacer para avisar o que deben hacer nuestros abogados? PREGUNTA:Mi suegra se hizo ciudadana en el 2017 y ella pidió a sus dos hijos que están en Mexico. Uno tiene 25 y el otro tiene 21, pero no les ha salido nada. ¿Quieren saber si esta espera es normal? ¿Podrían pedir visa de turista o permiso para viajar antes? PREGUNTA:Mi hermano está casado con una ciudadana americana. Tenía su proceso para ajuste de estatus, pero fue detenido y deportado. ¿Cree que pueda seguir su caso? El llevaba 13 años en el país y tiene 2 hijos ciudadanos. PREGUNTA:Mi amiga fue arrestada y ya esta con inmigración. Ella tiene una orden de deportación de hace muchos años. ¿Hay alguna posibilidad que ella pueda pelear su caso? Ella tiene dos hijos nacidos aquí.PREGUNTA:¿Qué tan cierto es que una persona de 65 anos con 20 anos con la residencia permanente puede estudiar solamente 20 preguntas para el examen de ciudadanía y les preguntan solo 10? Si es cierto, ¿Dónde les facilitan las 20 preguntas? Aviso: La información que reciben por este medio es de carácter general y no substituye una consulta formal con un abogado.Haga "clic" en el enlace

Is Bad Bunny in trouble with the FCC? Congressman Randy Fine is asking the FCC to look into Bad Bunny's Halftime Show performance over explicit language violations. WAPO refers to Bad Bunny's halftime show as "wholesome" Bad Bunny wiped every post from his Instagram page. Kid Rock tops Bad Bunny on Apple iTunes chart.following the All-American Halftime Show. The 9th Circuit ruled in favor of DHS being able to revoke TPS status of "refugees" in the US. A federal judge blocked Cali's "unmask ICE" law.     Join UNGOVERNED on LFA TV every MONDAY - FRIDAY from 10am to 11am EASTERN!    www.FarashMedia.com www.LFATV.us www.OFPFarms.com www.SLNT.com/SHAWN 

MegaETH mainnet is live, kicking off a new frontier for Ethereum scaling: ultra-low latency, massive throughput, and an execution environment built to unlock apps that can't exist on L1. Lei Yang & Namik break down why Vitalik's latest L2 framing validates “barbell” scaling, what users actually inherit from Ethereum (censorship resistance, exit guarantees, and fraud-proof security assumptions), and why stages + governance are harder than they look.  Plus: the mainnet stress test (11.4B tx in 7 days, 55k peak TPS), the economics shift toward stablecoin yield with USDM, proximity markets for MEV, and MegaETH's aggressive app-incubation strategy. ------

MERCH ALERT! Perfect gifts for TPS listeners...Delightful almond-scented soap that contains a full set of dice! You can get yours here: https://fantasy-scents.com/products/total-party-skill-dice-soap-dungeons-bubbles This week's segments: 1. The New Pugilist Class 2. Homebrewing "The Plagiarist Wizard" 3. Draft of Best Pugilists in Fiction Support us on Patreon https://www.patreon.com/c/TotalPartySkill/home to get access to PDFs of our homebrew and see uncut video from the podcast! Plus, bonus content exclusive only to patrons! Subscribe for more weekly Dungeons & Dragons content! And follow us on our socials for previous draft videos and to learn more about us: Gabe -- @gabespan (TikTok, Instagram) George -- @dmgeorge_primavera (Instagram, TikTok) Dylan -- @whatcha_mccollum (Instagram)

En nuestro show semanal “Tus Derechos”, la abogada Stacy Ehrisman, habló sobre los cambios más recientes y preocupantes en inmigración y respondieron decenas de preguntas en vivo de nuestra comunidad.Durante este programa se habló, entre otros temas, sobre:

Radell Lewis kicks off the Purple Political Breakdown's weekly Ohio midterm election series by diving deep into the 2026 Ohio governor race between Republican Vivek Ramaswamy and Democrat Dr. Amy Acton. With Governor Mike DeWine term-limited, this open seat race is shaping up to be one of the most competitive in Ohio history and Radell breaks down exactly why.In this episode, Radell covers both candidates' backgrounds, character, and policy positions on the issues Ohioans care about most: cost of living, tax cuts, energy costs, job growth, education and the controversial EdChoice voucher program, healthcare and reproductive rights, public safety and crime, corruption and government reform, workers and labor rights, and elder care. He also shares his honest, unfiltered analysis on each issue from deregulation and data centers to why "tax cuts" might be a red herring.Plus, Radell covers critical Ohio news you need to know: the First Energy HB6 corruption trial, the threat facing Springfield's Haitian community under TPS termination, and what to watch as the 2026 primaries approach.Whether you're an Ohio voter looking to get informed or a political junkie following state-level races, this episode gives you the breakdown without the bias.New episodes every Saturday at 8 AM EST. Rate, share, and reach out at TheTrendGoldenFaith@gmail.com.#OhioPolitics #OhioGovernorRace2026 #VivekRamaswamy #AmyActon #OhioMidterms #EdChoice #FirstEnergyScandal #PurplePoliticalBreakdown #OhioElections #NonpartisanPolitics #SpringfieldOhio #MedicaidCuts #OhioVoters #DOGE #TrumpEndorsementStandard Resource Links & RecommendationsThe following organizations and platforms represent valuable resources for balanced political discourse and democratic participation: PODCAST NETWORKALIVE Podcast Network - Check out the ALIVE Network where you can catch a lot of great podcasts like my own, led by amazing Black voices. Link: https://alivepodcastnetwork.com/ CONVERSATION PLATFORMSHeadOn - A platform for contentious yet productive conversations. It's a place for hosted and unguided conversations where you can grow a following and enhance your conversations with AI features. Link: https://app.headon.ai/Living Room Conversations - Building bridges through meaningful dialogue across political divides. Link: https://livingroomconversations.org/ UNITY MOVEMENTSUs United - A movement for unity that challenges Americans to step out of their bubbles and connect across differences. Take the Unity Pledge, join monthly "30 For US" conversation calls, wear purple (the color of unity), and participate in National Unity Day every second Saturday in December. Their programs include the Sheriff Unity Network and Unity Seats at sports events, proving that shared values are stronger than our differences. Link: https://www.us-united.org/ BALANCED NEWS & INFORMATIONOtherWeb - An AI-based platform that filters news without paywalls, clickbait, or junk, helping you access diverse, unbiased content. Link: https://otherweb.com/ VOTING REFORM & DEMOCRACYEqual Vote Coalition & STAR Voting - Advocating for voting methods that ensure every vote counts equally, eliminating wasted votes and strategic voting. Link: https://www.equal.vote/starFuture is Now Coalition (FiNC) - A grassroots movement working to restore democracy through transparency, accountability, and innovative technology while empowering citizens and transforming American political discourse. Link: https://futureis.org/ POLITICAL ENGAGEMENTIndependent Center - Resources for independent political thinking and civic engagement. Link: https://www.independentcenter.org/ GET DAILY NEWSText 844-406-INFO (844-406-4636) with code "purple" to receive quick, unbiased, factual news delivered to your phone every morning via Informed (https://informed.now) ALL LINKShttps://linktr.ee/purplepoliticalbreakdownThe Purple Political Breakdown is committed to fostering productive political dialogue that transcends partisan divides. We believe in the power of conversation, balanced information, and democratic participation to build a stronger society. Our mission: "Political solutions without political bias."Subscribe, rate, and share if you believe in purple politics - where we find common ground in the middle! Also if you want to be apart of the community and the conversation make sure to Join the Discord: https://discord.gg/ptPAsZtHC9

On this episode of The South Florida Roundup, we went back to the future to discuss Florida's new English-only drivers license test, which in Miami is a historically sore subject — and the subject of a new play that just opened here [1:09]. We also examined what's feeling like a trend: cities in Broward County opting out of law enforcement contracts with the Broward Sheriff's Office [19:22]. And we looked at what's next after a federal judge blocked cancellation of Haitian TPS — and where TPS stands after 35 years [33:12].

The Temporary Protected Status (TPS) for thousands of Haitian families living in Ohio has been temporarily extended. Previously, a federal judge stepped in at the last minute and blocked the Trump administration's attempt to end the TPS agreement.With their protected status still in effect, many Haitians in Ohio can breathe a sigh of relief– for now.But a court battle over the issue will continue. And the temporary stay does not take away the worries about immigration enforcement activity.We're talking about the status of the Haitian community in Ohio and the impact they have on the Buckeye state.Guests:Emily Brown, director, The Ohio State University Moritz College of Law's Immigration Clinic - (00:00)Sophia Pierrelus, entrepreneur/former secretary of the Mouvement Patriotique des Haïtiens Conscients - (17:01)Viles Dorsainvil, executive director, Haitian Community Help and Support Center - (36:17)If you have a disability and would like a transcript or other accommodation, you can request an alternative format.(Photo Credit: Jessie Wardarski / AP)

This week, 330,000 Haitian immigrants who've lived and worked in the U.S. legally, sometimes for decades, were set to lose their immigration protections.That's after the Trump administration announced it would end Temporary Protected Status, or TPS, for Haitians on Feb. 3. After a federal court order on Monday, the program remains in place for now, but could still be undone. The administration says it will appeal the ruling, potentially to the U.S. Supreme Court.What does it mean for Haitians who rely on TPS, who could go from integral parts of their community to undocumented immigrants? Even if they never crossed a border illegally or overstayed a visa?Find more of our programs online. Listen to 1A sponsor-free by signing up for 1A+ at plus.npr.org/the1a.Learn more about sponsor message choices: podcastchoices.com/adchoicesNPR Privacy Policy

Today's Headlines: Europe was unusually productive yesterday. French authorities raided Twitter's Paris offices as part of a cybercrime investigation, summoned Elon Musk and former CEO Linda Yaccarino (voluntarily, lol), and announced France is ditching Zoom and Microsoft Teams in favor of its own platform. Spain followed up by unveiling plans to crack down on social media algorithms and hold tech executives personally liable for illegal or hateful content, after Prime Minister Pedro Sánchez accused Musk of amplifying disinformation about Spain's immigration policy. Not to be outdone, Poland's prime minister said Jeffrey Epstein was likely a Russian intelligence asset — and said his government plans to investigate. Back in the U.S., Trump floated the idea of “nationalizing” elections during a podcast appearance and teased more fallout from last week's FBI raid in Georgia, despite elections being run by states under the Constitution. Democrats held a public forum on ICE abuses that Republicans skipped entirely, featuring testimony from people shot at, assaulted, or detained without cause — including a disabled woman who says she was dragged from her car and later treated in an ER for assault. Meanwhile, ICE is reportedly preparing a major operation targeting Haitian immigrants in Ohio as TPS protections expire, even as the agency quietly spends hundreds of millions buying warehouses to convert into detention centers.Elsewhere, DC U.S. Attorney Jeanine Pirro briefly threatened jail time for anyone bringing a gun into the district before walking it back, Trump continued his Kennedy Center renovation saga, and New York Magazine published a deeply unsettling profile of Rep. Nancy Mace detailing erratic behavior and staff misuse.  Resources/Articles mentioned in this episode: NBC News: Paris prosecutors summon Elon Musk after raid on X's French offices BBC: Spain announces plans to ban social media for under-16s The Telegraph: Epstein was probably a Russian spy, says Tusk WaPo: Trump says he wants to ‘nationalize the voting,' a power granted to states The New Republic: Not a Single Republican Shows Up to Hear Renee Good's Brothers Testify WaPo: Renée Good's brothers, others describe assaults, shootings at hearing MS Now: ICE eyeing Ohio next, where it is expected to target Haitian immigrants Bloomberg: ICE Begins Buying ‘Mega' Warehouse Detention Centers Across US MS Now: Pirro walks back threat to lawful gun owners traveling to D.C. NBC News: Kennedy Center won't be torn down during $200 million renovation, Trump says NY Magazine: Nancy Mace Is Not Okay Morning Announcements is produced by Sami Sage and edited by Grace Hernandez-Johnson Learn more about your ad choices. Visit megaphone.fm/adchoices

Retired Waltham Police Sergeant and NEMLEC SWAT operator Jim Vaglica returns to Things Police See to deliver a full, unfiltered account of his response to the Boston Marathon bombing and the massive manhunt that followed. Jim walks listeners through the moment the bombs detonated, the chaos of deploying into Boston, the tense overnight searches in Watertown, and the dramatic final standoff where the second bomber was captured. His firsthand perspective reveals what really happened behind the scenes — the communication breakdowns, the tactical challenges, the danger of unexploded IEDs, and the sheer exhaustion of operators working more than 24 hours straight. This episode is a rare, detailed look at SWAT operations during one of the most significant domestic terrorism events in U.S. history. If you're interested in law enforcement, tactical operations, crisis response, or the Boston Marathon bombing, this interview is essential listening. Follow Jim on X - https://x.com/JimVaglica Contact Steve - steve@thingspolicesee.com Support the TPS show by joining the Patreon community today! https://www.patreon.com/user?u=27353055 Sergeant Steve YouTube Channel -  https://www.youtube.com/@TheSergeantSteve  

Trump Wants to Deport Legal Haitians + Suggests States Aren’t Running Honest Elections See omnystudio.com/listener for privacy information.

House passes funding package to end partial government shutdown; ME leads on climate action as U.S. withdraws from global agreements; Amid federal DEI rollbacks, MS Black women face job loss and severe wage gap; Judge denies Trump bid to end TPS for Haitians as ICE fears loom; Report: Feds have delivered on Project 2025 at expense of public lands.

Minneapolis journalist reflects on continued ICE operation following deaths of Renee Good and Alex Pretti All eyes have been on Minneapolis in recent weeks, following the deployment of large numbers of ICE and Customs and Border Protection agents to the area in December. The heightened federal presence has coincided with deadly use-of-force incidents that have ignited national concern, including the fatal shootings of ICU nurse Alex Pretti on Jan. 24 and poet and mother of three Renée Nicole Good on Jan. 7. Those and other deaths, as well as the federal government's handling of the investigations, have become focal points of protests, calls for accountability, and broader debates about public safety and civil liberties. Earlier this week, the "Sound of Ideas" Host Stephanie Haney spoke with Minnesota Star Tribune Opinion Editor Phillip Morris. Morris is also a former longtime columnist for the Cleveland Plain Dealer. He shared what he's been seeing on the ground and his thoughts on the broader political and legal ramifications to come. Wednesday's show will start with that conversation, then we'll turn to Springfield, Ohio, where Gov. Mike DeWine recently warned of a potential ICE operation coming to central Ohio. More than 12,000 Haitian immigrants with temporary legal status were about to see their protections end this week, before a judge delayed that order Monday. Guest: - Phillip Morris, Opinion Editor & Vice President, Minnesota Star Tribune Judge ruling keeps legal protections for Springfield's Haitian immigrants intact Springfield, Ohio is home to a large Haitian immigrant community living with Temporary Protected Status. TPS is a federal designation that allows people from countries facing extraordinary conditions such as natural disasters or ongoing instability, to live and work legally in the U.S. For Haitians, that protection was first granted after a massive earthquake in 2010 and has been renewed several times amid continued political and humanitarian crises, such as the assassination of Haiti's president in 2021. The most recent extension was set to expire on Feb. 3. But on Monday, a federal district judge temporarily blocked the Trump administration from ending TPS. In addition, residents are bracing for a possible ICE enforcement operation reported to begin today. According to the Department of Homeland Security, as of Dec. 16, ICE agents have arrested at least 280 residents in Columbus and the surrounding area, in what has been called Operation Buckeye. Guests: - Kathryn Mobley, Education and Politics Reporter, WYSO - Heather Prendergast, Immigration Attorney, Aljijakli, Kosseff & Prendergast, LLC - Marjory Wentworth, Leadership Team Member, Springfield G92 - Viles Dorsainvil, Executive Director, Haitian Community Help and Support Center

We dive into President Trump's sharp response to the latest Epstein document release and questions swirling around high-profile figures like the Clintons facing congressional scrutiny. We examine the ongoing push for the SAVE Act in the Senate, including Majority Leader Thune's outlook, rumored filibuster shenanigans, and skeptical takes from key Republicans on its path forward. Plus, public opinion trends on mass deportations and ICE amid protests, a federal judge's block on ending TPS for Haitians, church-led "trainings" raising interference concerns, a Democrat Senate candidate's controversial "biblical" take on abortion, and other headlines from missing persons to patriotic alternatives to the Super Bowl halftime.   The AM Update, Epstein files, SAVE Act, voter ID, immigration enforcement, mass deportations, ICE protests, TPS Haiti, filibuster reform, John Thune, Clintons Epstein, Trump Truth Social, abortion consent debate, government funding

Don is on the move this morning, so Katie Phang is guest hosting to bring you all the breaking news of the day. We're diving into Donald Trump's attacks on TPS protections for Haitians, the raid in Fulton County, and of course, the latest bombshells from the Epstein files that just won't stop coming. This episode is sponsored by the Freedom From Religion Foundation. Go to https://FFRF.US/NEW YEAR or text “DON” to Five Eleven Five Eleven. And help protect a country that belongs to all of us. This episode is brought to you by BetterHelp. BetterHelp makes it easy to get matched online with a qualified therapist. Sign up and get 10% off at https://BetterHelp.com/donlemon This episode is sponsored by Shopify. Sign up for your one-dollar-per-month trial and start selling today at https://SHOPIFY.COM/lemon This episode is brought to you Lean. Let's get you started with 20% off and free rush shipping so you can add LEAN to you healthy diet and exercise plan. Visit https://TAKELEAN.com and enter LEMON for your discount. Learn more about your ad choices. Visit megaphone.fm/adchoices

President Trump is revoking Temporary Protected Status from Haitians in the United States, putting them at risk of deportation to a country experiencing unprecedented violence and a political crisis. Macollvie Neel, special projects editor at The Haitian Times, discusses the looming uncertainty for the hundreds of thousands of Haitians who will be affected.

Eli Lilly Plans Historic $3.5B Investment In Pennsylvania. Dems take another seat in TEXAS special election. The scam of TPS. Trevor Noah takes jab at Donald Trump during the Grammy's. Pascal Siakam has been named to his fourth #NBA All Star Game despite how their regular season is going. JMV joins to discuss. Today’s Popcorn Moment: Teachers indoctrinating children. Today on the Marketplace: Used Uggs. UN on the verge of bankruptcy Left continues to attack ICE. Don Lemon arrest. Billie Eilish accepts Grammy on stolen land. Disney's good earning's report. What's that TV Theme Song? Redemption Monday - Love Connection. Teachers are indoctrinating. See omnystudio.com/listener for privacy information.

Eli Lilly Plans Historic $3.5B Investment In Pennsylvania. Dems take another seat in TEXAS special election. The scam of TPS. Trevor Noah takes jab at Donald Trump during the Grammy'sSee omnystudio.com/listener for privacy information.

Today on the show: Haiti Action co-founder, Robert Roth joins us live from a protest on the streets of San Francisco. Folks are in the streets in support of the continued availability of Temporary Protective Status for Haitians living in exile in the US. TPS is slotted to end tomorrow/cutoff cold by Trump: And Flashpoints senior producer Miguel Gavilan Molina is in San Francisco's Mission District at Historic Dolores Park, reporting on the people's growing resistance to ICE and blatant trump Racism The post Protests In The Streets For Temporary Protected Status, Scheduled to End Tomorrow By Trump Admin appeared first on KPFA.

MERCH ALERT! Perfect gifts for TPS listeners...Delightful almond-scented soap that contains a full set of dice! You can get yours here: https://fantasy-scents.com/products/total-party-skill-dice-soap-dungeons-bubbles This week's segments: 1. The New Player's Perspective 2. Homebrewing "The Duskmantle" 3. Draft of Best Musicals to Adapt into your D&D Campaign Support us on Patreon https://www.patreon.com/c/TotalPartySkill/home to get access to PDFs of our homebrew and see uncut video from the podcast! Plus, bonus content exclusive only to patrons! Subscribe for more weekly Dungeons & Dragons content! And follow us on our socials for previous draft videos and to learn more about us: Gabe -- @gabespan (TikTok, Instagram) George -- @dmgeorge_primavera (Instagram, TikTok) Dylan -- @whatcha_mccollum (Instagram) Joey -- @jonyricker (Instagram) // @joeyrichter (X)

Docket Alerts:Director of National Intelligence Tulsi Gabbard led a raid on the Fulton County Election Hub and Operating Center in Atlanta. ProPublica got the warrant. Mo Ivory, a Democratic commissioner for Fulton County, breaks it down on Instagram.In Chicago, Marimar Martinez has moved to unseal evidence from DOJ's failed effort to prosecute her for getting shot by ICE.Reuters reports that Marcos Charles, the top official in ICE's Enforcement and Removal Operations division, issued new guidance instructing ICE to target only immigrants who have been arrested or convicted of crimes. This would be a huge improvement, but DHS won't comment.Main Show:Once again, this is all the Supreme Court's fault. Specifically, its rulings in J.G.G. v. Trump and Trump v. CASA led directly to the mayhem in Minnesota. First the Court forced immigrants challenging their detention to file thousands of individual habeas cases. And then they drastically limited the power of federal judges to issue relief when it “discovered” that nationwide injunctions are illegal. The Trump administration took this as an invitation to break the law, irrespective of how many courts tell them not to, on the theory that CASA means precedent doesn't count any more. DHS dummied up a memo saying that actually everyone without a green card must be held indefinitely. This is a gross misstatement of the law, as literally hundreds of courts have already ruled. But the Trump administration says because of CASA, they can continue to lock up people who've lived here for decades, checking in with DHS, working, paying taxes, and taking care of their families.Judges are deluged with habeas petitions, which differ from each other only in the particulars of the cruelty being visited upon the individual immigrant. After ICE failed to obey a court order to release a habeas petitioner, Chief Judge Patrick Schiltz in the District Court of Minnesota ordered Todd Lyons, the Acting Director of ICE, to either release the guy or show up and explain why he shouldn't be held in contempt of court. ICE released the petitioner, but Judge Schiltz was still furious. He published a list of 96 violations of court orders in January alone — and that's only in Minnesota! Thanks, Chief Justice Roberts!On the plus side, Judge Schiltz's colleague Judge John Tunheim issued a TRO ordering ICE to release every refugee detained under the erroneous memo and quit kidnapping them and spiriting them away to Texas.And for subscribers, we'll discuss the Ninth Circuit's ruling that bars Kristi Noem from unilaterally canceling temporary protected status for a million Venezuelans and Haitians.Hundreds of judges reject Trump's mandatory detention policy, with no end in sighthttps://www.politico.com/news/2026/01/05/trump-administration-immigrants-mandatory-detention-00709494Fulton County Election Hub Warranthttps://www.documentcloud.org/documents/26513986-1-28-26-fulton-warrant/Marimar Martinez Motion to Unsealhttps://storage.courtlistener.com/recap/gov.uscourts.ilnd.487595/gov.uscourts.ilnd.487595.100.0.pdfExclusive: ICE officers in Minnesota directed not to interact with 'agitators' in new ordershttps://www.reuters.com/world/ice-officers-minnesota-directed-not-interact-with-agitators-new-orders-2026-01-29/J.G.G. v. Trumphttps://www.supremecourt.gov/opinions/24pdf/24a931_2c83.pdfTrump v. CASAhttps://www.supremecourt.gov/opinions/24pdf/24a884_8n59.pdfTobay Robles v. Noemhttps://www.courtlistener.com/docket/72120823/tobay-robles-v-noemJudge Tunheim TROhttps://storage.courtlistener.com/recap/gov.uscourts.mnd.230526/gov.uscourts.mnd.230526.41.0.pdfShow Links:https://www.lawandchaospod.com/BlueSky: @LawAndChaosPodThreads: @LawAndChaosPodTwitter: @LawAndChaosPodSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In line with President Trump's broader crackdown on immigration, the administration has moved to end the Temporary Protected Status program for certain countries including Venezuela and Haiti. TPS has allowed immigrants from countries with unsafe environments to temporarily live and work legally in the United States for decades. On today's show, Marketplace's Elizabeth Trovall joins Kimberly to share her recent reporting on Haitian care workers in Florida who will soon lose their legal status and the wider impact it could have on the U.S. economy.

In line with President Trump's broader crackdown on immigration, the administration has moved to end the Temporary Protected Status program for certain countries including Venezuela and Haiti. TPS has allowed immigrants from countries with unsafe environments to temporarily live and work legally in the United States for decades. On today's show, Marketplace's Elizabeth Trovall joins Kimberly to share her recent reporting on Haitian care workers in Florida who will soon lose their legal status and the wider impact it could have on the U.S. economy.

Former FBI agent Barry Black joins Things Police See to share gripping firsthand accounts from his 31‑year career. Barry served as a sniper at Waco, responded to the Oklahoma City bombing, worked the Atlanta Olympic bombing, and deployed to Ground Zero after 9/11. He also trained military and law‑enforcement personnel around the world and recently released his memoir Hazardous Devices. In this interview, Barry breaks down what really happened at Waco, describes the chaos of Oklahoma City, explains the evolution of bomb‑tech work, and shares unbelievable stories from financial‑crime investigations to international terrorism cases. This episode offers rare insight into the realities of federal law enforcement, high‑risk operations, and the human side of policing. If you're interested in FBI operations, SWAT, bomb disposal, true crime, or behind‑the‑scenes law‑enforcement stories, this is an episode you won't forget. Barry's Book - https://a.co/d/dJf7WQJ Contact Steve - steve@thingspolicesee.com Support the TPS show by joining the Patreon community today! https://www.patreon.com/user?u=27353055 Sergeant Steve - Bodycam breakdowns https://www.youtube.com/@UCuobtuGxJny9V5lX5a1ieuw   

Revised GDP data for this past summer shows the U.S. economy grew faster than we initially thought. A few key parts of the private services sector propelled that growth. In this episode, which parts of the economy are actually doing pretty well. Then: Gap leans in to “fashiontainment,” packaging costs weigh on food prices, and elderly care facilities stand to lose critical employees when TPS ends for Haitian immigrants.Every story has an economic angle. Want some in your inbox? Subscribe to our daily or weekly newsletter.Marketplace is more than a radio show. Check out our original reporting and financial literacy content at marketplace.org — and consider making an investment in our future.

Revised GDP data for this past summer shows the U.S. economy grew faster than we initially thought. A few key parts of the private services sector propelled that growth. In this episode, which parts of the economy are actually doing pretty well. Then: Gap leans in to “fashiontainment,” packaging costs weigh on food prices, and elderly care facilities stand to lose critical employees when TPS ends for Haitian immigrants.Every story has an economic angle. Want some in your inbox? Subscribe to our daily or weekly newsletter.Marketplace is more than a radio show. Check out our original reporting and financial literacy content at marketplace.org — and consider making an investment in our future.

Dive into gripping real-life stories from the front lines of law enforcement in this powerful episode of Things Police See Podcast with host Steve Gould (Ole Gingerface). Guest Cameron Pavlicek, an active Montana narcotics investigator, Afghanistan war veteran, former president of the Montana Narcotics Officers Association, and founder of Yellowstone Narcotics training company, shares intense, bizarre, and eye-opening experiences. Hear about a chilling first homicide call in freezing Montana conditions, using a baby as collateral in a meth deal gone wild, a 36-hour armed standoff ending in tragedy, creative undercover social media operations catfishing drug dealers online (posing as women to bust perps), bizarre encounters with a schizophrenic man carrying a stolen 100-pound welded California sculpture, and much more. Perfect for fans of true police stories, narcotics investigations, undercover ops, body cam breakdowns, and rural policing in the American West. Don't miss these raw, unfiltered cop tales from the Big Sky State! Yellowstone Narcotics      https://yellowstonenarcotics.com/ Contact Steve - steve@thingspolicesee.com Support the TPS show by joining the Patreon community today! https://www.patreon.com/user?u=27353055 Sergeant Steve - Bodycam Breakdowns https://www.youtube.com/@UCuobtuGxJny9V5lX5a1ieuw

The Clintons defy House Oversight subpoenas in the Epstein probe, triggering a looming contempt vote - Article 3 Project Senior Counsel Will Chamberlain weighs in. President Trump launches the next phase of his immigration crackdown, ending TPS for Somalia and cutting off federal funds to sanctuary jurisdictions. The Trump administration escalates pressure on Iran, with the President openly encouraging protesters to keep pushing, as U.S. officials weigh covert and military options. Scott Adams, the creator of Dilbert and a singular cultural and political voice, dies at 68 after a battle with stage-four prostate cancer, leaving behind a legacy of satire, persuasion, and fearless commentary. Herald Group: Learn more at https://GuardYourCard.com Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.